Science.gov

Sample records for icnirp reference level

  1. Children and adults exposed to electromagnetic fields at the ICNIRP reference levels: theoretical assessment of the induced peak temperature increase

    NASA Astrophysics Data System (ADS)

    Bakker, J. F.; Paulides, M. M.; Neufeld, E.; Christ, A.; Kuster, N.; van Rhoon, G. C.

    2011-08-01

    To avoid potentially adverse health effects of electromagnetic fields (EMF), the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined EMF reference levels. Restrictions on induced whole-body-averaged specific absorption rate (SARwb) are provided to keep the whole-body temperature increase (Tbody, incr) under 1 °C during 30 min. Additional restrictions on the peak 10 g spatial-averaged SAR (SAR10g) are provided to prevent excessive localized tissue heating. The objective of this study is to assess the localized peak temperature increase (Tincr, max) in children upon exposure at the reference levels. Finite-difference time-domain modeling was used to calculate Tincr, max in six children and two adults exposed to orthogonal plane-wave configurations. We performed a sensitivity study and Monte Carlo analysis to assess the uncertainty of the results. Considering the uncertainties in the model parameters, we found that a peak temperature increase as high as 1 °C can occur for worst-case scenarios at the ICNIRP reference levels. Since the guidelines are deduced from temperature increase, we used Tincr, max as being a better metric to prevent excessive localized tissue heating instead of localized peak SAR. However, we note that the exposure time should also be considered in future guidelines. Hence, we advise defining limits on Tincr, max for specified durations of exposure.

  2. Children and adults exposed to electromagnetic fields at the ICNIRP reference levels: theoretical assessment of the induced peak temperature increase.

    PubMed

    Bakker, J F; Paulides, M M; Neufeld, E; Christ, A; Kuster, N; van Rhoon, G C

    2011-08-01

    To avoid potentially adverse health effects of electromagnetic fields (EMF), the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined EMF reference levels. Restrictions on induced whole-body-averaged specific absorption rate (SAR(wb)) are provided to keep the whole-body temperature increase (T(body, incr)) under 1 °C during 30 min. Additional restrictions on the peak 10 g spatial-averaged SAR (SAR(10g)) are provided to prevent excessive localized tissue heating. The objective of this study is to assess the localized peak temperature increase (T(incr, max)) in children upon exposure at the reference levels. Finite-difference time-domain modeling was used to calculate T(incr, max) in six children and two adults exposed to orthogonal plane-wave configurations. We performed a sensitivity study and Monte Carlo analysis to assess the uncertainty of the results. Considering the uncertainties in the model parameters, we found that a peak temperature increase as high as 1 °C can occur for worst-case scenarios at the ICNIRP reference levels. Since the guidelines are deduced from temperature increase, we used T(incr, max) as being a better metric to prevent excessive localized tissue heating instead of localized peak SAR. However, we note that the exposure time should also be considered in future guidelines. Hence, we advise defining limits on T(incr, max) for specified durations of exposure.

  3. Children and adults exposed to low-frequency magnetic fields at the ICNIRP reference levels: theoretical assessment of the induced electric fields

    NASA Astrophysics Data System (ADS)

    Bakker, J. F.; Paulides, M. M.; Neufeld, E.; Christ, A.; Chen, X. L.; Kuster, N.; van Rhoon, G. C.

    2012-04-01

    To avoid potentially adverse health effects, the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined reference levels for time varying magnetic fields. Restrictions on the electric fields induced in the human body are provided based on biological response data for peripheral nerve stimulation and the induction of phosphenes. Numerical modeling is commonly used to assess the induced electric fields for various exposure configurations. The objective of this study was to assess the variations of the electric fields induced in children and adults and to compare the exposure at reference levels with the basic restrictions as function of anatomy. We used the scalar potential finite element method to calculate the induced electric fields in six children and two adults when exposed to uniform magnetic fields polarized in three orthogonal directions. We found that the induced electric fields are within the ICNIRP basic restrictions in nearly all cases. In PNS tissues, we found electric fields up to 95% (upper uncertainty limit due to discretization errors, k = 2) of the ICNIRP basic restrictions for exposures at the general public reference levels. For occupational reference levels, we found an over-exposure of maximum 79% (k = 2) in PNS tissues. We further found that the ICNIRP recommendations on spatial averaging in 2 × 2 × 2 mm3 contiguous tissue volumes and removal of peak values by the 99th percentile cause the results to depend strongly on the grid discretization step (i.e. an uncertainty of more than 50% at 2 mm) and the number of distinguished tissues in the anatomical models. The computational results obtained by various research institutes should be robust for different discretization settings and various anatomical models. Therefore, we recommend considering alternative routines for small anatomical structures such as non-contiguous averaging without taking the 99th percentile in future guidelines leading to consistent

  4. Children and adults exposed to low-frequency magnetic fields at the ICNIRP reference levels: theoretical assessment of the induced electric fields.

    PubMed

    Bakker, J F; Paulides, M M; Neufeld, E; Christ, A; Chen, X L; Kuster, N; van Rhoon, G C

    2012-04-01

    To avoid potentially adverse health effects, the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined reference levels for time varying magnetic fields. Restrictions on the electric fields induced in the human body are provided based on biological response data for peripheral nerve stimulation and the induction of phosphenes. Numerical modeling is commonly used to assess the induced electric fields for various exposure configurations. The objective of this study was to assess the variations of the electric fields induced in children and adults and to compare the exposure at reference levels with the basic restrictions as function of anatomy. We used the scalar potential finite element method to calculate the induced electric fields in six children and two adults when exposed to uniform magnetic fields polarized in three orthogonal directions. We found that the induced electric fields are within the ICNIRP basic restrictions in nearly all cases. In PNS tissues, we found electric fields up to 95% (upper uncertainty limit due to discretization errors, k = 2) of the ICNIRP basic restrictions for exposures at the general public reference levels. For occupational reference levels, we found an over-exposure of maximum 79% (k = 2) in PNS tissues. We further found that the ICNIRP recommendations on spatial averaging in 2 × 2 × 2 mm³ contiguous tissue volumes and removal of peak values by the 99th percentile cause the results to depend strongly on the grid discretization step (i.e. an uncertainty of more than 50% at 2 mm) and the number of distinguished tissues in the anatomical models. The computational results obtained by various research institutes should be robust for different discretization settings and various anatomical models. Therefore, we recommend considering alternative routines for small anatomical structures such as non-contiguous averaging without taking the 99th percentile in future guidelines leading to consistent

  5. Radio Hazard Safety Assessment for Marine Ship Transmitters: Measurements Using a New Data Collection Method and Comparison with ICNIRP and ARPANSA Limits

    PubMed Central

    Halgamuge, Malka N.

    2015-01-01

    We investigated the levels of radio frequency electromagnetic fields (RF EMFs) emitted from marine ship transmitters. In this study, we recorded the radio frequency (RF) electric field (EF) levels emitted from transmitters from a marine vessel focusing on the areas normally occupied by crew members and passengers. Previous studies considered radiation hazard safety assessment for marine vessels with a limited number of transmitters, such as very high-frequency (VHF) transceivers, radar and communication transmitters. In our investigation, EF levels from seven radio transmitters were measured, including: VHF, medium frequency/high frequency (MF/HF), satellite communication (Sat-Com C), AISnavigation, radar X-band and radar S-band. Measurements were carried out in a 40 m-long, three-level ship (upper deck, bridge deck and bridge roof) at 12 different locations. We developed a new data-collection protocol and performed it under 11 different scenarios to observe and measure the radiation emissions from all of the transmitters. In total, 528 EF field measurements were collected and averaged over all three levels of the marine ship with RF transmitters: the measured electric fields were the lowest on the upper deck (0.82–0.86 V/m), the highest on the bridge roof (2.15–3.70 V/m) and in between on the bridge deck (0.47–1.15 V/m). The measured EF levels were then assessed for compliance with the occupational and general public reference levels of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines and the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) standards. The ICNIRP and the ARPANSA limits for the general public were exceeded on the bridge roof; nevertheless, the occupational limits were respected everywhere. The measured EF levels, hence, complied with the ICNIRP guidelines and the ARPANSA standards. In this paper, we provide a new data collection model for future surveys, which could be conducted with

  6. Radio Hazard Safety Assessment for Marine Ship Transmitters: Measurements Using a New Data Collection Method and Comparison with ICNIRP and ARPANSA Limits.

    PubMed

    Halgamuge, Malka N

    2015-05-01

    We investigated the levels of radio frequency electromagnetic fields (RF EMFs) emitted from marine ship transmitters. In this study, we recorded the radio frequency (RF) electric field (EF) levels emitted from transmitters from a marine vessel focusing on the areas normally occupied by crew members and passengers. Previous studies considered radiation hazard safety assessment for marine vessels with a limited number of transmitters, such as very high-frequency (VHF) transceivers, radar and communication transmitters. In our investigation, EF levels from seven radio transmitters were measured, including: VHF, medium frequency/high frequency (MF/HF), satellite communication (Sat-Com C), AISnavigation, radar X-band and radar S-band. Measurements were carried out in a 40 m-long, three-level ship (upper deck, bridge deck and bridge roof) at 12 different locations. We developed a new data-collection protocol and performed it under 11 different scenarios to observe and measure the radiation emissions from all of the transmitters. In total, 528 EF field measurements were collected and averaged over all three levels of the marine ship with RF transmitters: the measured electric fields were the lowest on the upper deck (0.82-0.86 V/m), the highest on the bridge roof (2.15-3.70 V/m) and in between on the bridge deck (0.47-1.15 V/m). The measured EF levels were then assessed for compliance with the occupational and general public reference levels of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines and the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) standards. The ICNIRP and the ARPANSA limits for the general public were exceeded on the bridge roof; nevertheless, the occupational limits were respected everywhere. The measured EF levels, hence, complied with the ICNIRP guidelines and the ARPANSA standards. In this paper, we provide a new data collection model for future surveys, which could be conducted with larger

  7. On the issues related to compliance assessment of ICNIRP 2010 basic restrictions.

    PubMed

    De Santis, Valerio; Chen, Xi Lin

    2014-06-01

    This article discusses technical issues related to compliance assessment of ICNIRP 2010 basic restrictions. Several difficulties are identified in this study when assessing the spatial average and 99th percentile value of the electric field. These issues are mainly attributed to the lack of clarity in the guideline specifications, which leads to inadequate or irreproducible results. Effects on compliance results due to such ambiguous procedures are hereby investigated, with particular focus on technical issues rather than biological ones. Examples spanning from simple canonical test cases to realistic applications have been selected to highlight the strong variability in dosimetry results. Based on our findings, revisiting the ICNIRP 2010 guidelines is strongly recommended, and proposed alternative solutions are outlined. PMID:24705441

  8. Is ICRP guidance on the use of reference levels consistent?

    PubMed

    Hedemann-Jensen, Per; McEwan, Andrew C

    2011-12-01

    In ICRP 103, which has replaced ICRP 60, it is stated that no fundamental changes have been introduced compared with ICRP 60. This is true except that the application of reference levels in emergency and existing exposure situations seems to be applied inconsistently, and also in the related publications ICRP 109 and ICRP 111. ICRP 103 emphasises that focus should be on the residual doses after the implementation of protection strategies in emergency and existing exposure situations. If possible, the result of an optimised protection strategy should bring the residual dose below the reference level. Thus the reference level represents the maximum acceptable residual dose after an optimised protection strategy has been implemented. It is not an 'off-the-shelf item' that can be set free of the prevailing situation. It should be determined as part of the process of optimising the protection strategy. If not, protection would be sub-optimised. However, in ICRP 103 some inconsistent concepts have been introduced, e.g. in paragraph 279 which states: 'All exposures above or below the reference level should be subject to optimisation of protection, and particular attention should be given to exposures above the reference level'. If, in fact, all exposures above and below reference levels are subject to the process of optimisation, reference levels appear superfluous. It could be considered that if optimisation of protection below a fixed reference level is necessary, then the reference level has been set too high at the outset. Up until the last phase of the preparation of ICRP 103 the concept of a dose constraint was recommended to constrain the optimisation of protection in all types of exposure situations. In the final phase, the term 'dose constraint' was changed to 'reference level' for emergency and existing exposure situations. However, it seems as if in ICRP 103 it was not fully recognised that dose constraints and reference levels are conceptually different. The

  9. Automatic reference level control for an antenna pattern recording system

    NASA Technical Reports Server (NTRS)

    Lipin, R., Jr.

    1971-01-01

    Automatic gain control system keeps recorder reference levels within 0.2 decibels during operation. System reduces recorder drift during antenna radiation distribution determinations over an eight hour period.

  10. The low-level radioactivity ocean sediment standard reference material

    SciTech Connect

    Inn, K.G.W.; Lin, Z.; Liggett, W.S.; Krey, P.W.

    1995-12-31

    Over the past decades, on the order of 10{sup 15} Becquerel nuclear waste have been stored in the oceans. Potential contamination of the oceans from leaking nuclear waste has caused world wide concern. Currently, early warning of ocean contamination near the waste dumping sites rely on monitoring systems being set up by different countries and agencies. Because the determination of low-level radioactivity in ocean sediment is a difficult technical task, a basis for measurement quality assurance, methods verification, and data comparability is needed. The recently certified NIST ocean sediment Standard Reference Material (SRM-4355) is a composite of 1% contaminated Irish Sea sediment and 99% of Chesapeake Bay sediment by weight. The sediments were blended, pulverized to a median particle size of 8 {mu}m, and reblended to achieve acceptable sample homogeneity. A statistical assessment of the intercomparison results from 19 laboratories has shown the material to be homogeneous down to 10 grams. The certified radionuclide concentration range from 0.4 to 230 mBq/g. A variety of radiochemical procedures and detection techniques have been used in the measurements to minimize possible systematic bias. Twelve radionuclides including {sup 40}K, {sup 90}Sr, {sup 137}Cs, {sup 226}Ra, {sup 228}Th, {sup 230}Th, {sup 232}Th, {sup 234}U, {sup 235}U, {sup 238}U, {sup 238}Pu, and {sup (239+240)}Pu were certified. The mean values were reported for an additional 10 uncertified radionuclides: {sup 129}I, {sup 155}Eu, {sup 210}Po, {sup 210}Pb, {sup 212}Pb, {sup 214}Pb, {sup 214}Bi, {sup 228}Ra, {sup 237}Np, and {sup 241}Am. The standard reference material in unit quantities of about 100 gram each will be available by the end of 1995.

  11. Patient Dose Reference Levels for Interventional Radiology: A National Approach

    SciTech Connect

    Vano, Eliseo Sanchez, R.; Fernandez, J. M.; Gallego, J. J.; Verdu, J. F.; Garay, M. Gonzalez de; Azpiazu, A.; Segarra, A.; Hernandez, M. T.; Canis, M.; Diaz, F.; Moreno, F.; Palmero, J.

    2009-01-15

    A set of patient dose reference levels (RLs) for fluoroscopically guided interventional procedures was obtained in a survey launched by the National Society of Interventional Radiology (IR), involving 10 public hospitals, as recommended by the European Medical Exposures Directive. A sample of 1391 dose values (kerma area product [KAP]) was collected randomly during clinical procedures for seven of the most frequent procedures. Third quartiles of the KAP distributions were used to set the RLs. A regular quality control of the X-ray systems and a calibration of the dose meters were performed during the survey. The fluoroscopy time and total number of digital subtraction angiography images per procedure were also analyzed. The RL values proposed were 12 Gy cm{sup 2} for fistulography (hemodialysis access; sample of 180 cases), 73 Gy cm{sup 2} for lower limb arteriography (685 cases), 89 Gy cm{sup 2} for renal arteriography (55 cases), 80 Gy cm{sup 2} for biliary drainage (205 cases), 289 Gy cm{sup 2} for hepatic chemoembolization (151 cases), 94 Gy cm{sup 2} for iliac stent (70 cases), and 236 Gy cm{sup 2} for uterine embolization (45 cases). The provisional national RL values are lower than those obtained in a similar survey carried out in the United States from 2002 to 2004. These new values could be used to improve the practice of centers consistently working with doses higher than the RLs. This national survey also had a positive impact, as it helped increase the awareness of the members of the National Society of IR on a topic as crucial as patient dose values and programs on radiation protection.

  12. Low-level lasers and mRNA levels of reference genes used in Escherichia coli

    NASA Astrophysics Data System (ADS)

    Teixeira, A. F.; Machado, Y. L. R. C.; Fonseca, A. S.; Mencalha, A. L.

    2016-11-01

    Low-level lasers are widely used for the treatment of diseases and antimicrobial photodynamic therapy. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) is widely used to evaluate mRNA levels and output data from a target gene are commonly relative to a reference mRNA that cannot vary according to treatment. In this study, the level of reference genes from Escherichia coli exposed to red or infrared lasers at different fluences was evaluated. E. coli AB1157 cultures were exposed to red (660 nm) and infrared (808 nm) lasers, incubated (20 min, 37 °C), the total RNA was extracted, and cDNA synthesis was performed to evaluate mRNA levels from arcA, gyrA and rpoA genes by RT-qPCR. Melting curves and agarose gel electrophoresis were carried out to evaluate specific amplification. Data were analyzed by geNorm, NormFinder and BestKeeper. The melting curve and agarose gel electrophoresis showed specific amplification. Although mRNA levels from arcA, gyrA or rpoA genes presented no significant variations trough a traditional statistical analysis, Excel-based tools revealed that these reference genes are not suitable for E. coli cultures exposed to lasers. Our data showed that exposure to low-level red and infrared lasers at different fluences alter the mRNA levels from arcA, gyrA and rpoA in E. coli cells.

  13. Development of a low-level radon reference atmosphere.

    PubMed

    Linzmaier, Diana; Röttger, Annette

    2013-11-01

    In order to calibrate measurement devices for the activity concentration of Rn-222 (radon) in air below 1,000 Bq/m(3), a constant for long time (>5d), homogeneous reference atmosphere is created by a certified activity in a certified volume. The PTB developed this reference atmosphere from 150 Bq/m(3) to 2,000 Bq/m(3) based on the precisely known emanation of Rn-222 from a Ra-226 activity standard. This set-up reduces uncertainties and increases the range of traceability for commercial radon measurement devices. Thus, a gap in radon metrology is closed. The new primary standard for reference atmospheres is realised with a combined relative standard uncertainty of 1.1%.

  14. Radiometer calibration procedure and beacon attenuation estimation reference level

    NASA Technical Reports Server (NTRS)

    Crane, Robert K.

    1994-01-01

    The primary objectives are to compare radiometer attenuation with beacon attenuation and to compare sky temperature estimates with calculations using simultaneous meteorological data. Secondary objectives are: (1) noise diode and reference load measurements and (2) to adjust for outside temperature and component temperature changes.

  15. Reference commercial high-level waste glass and canister definition.

    SciTech Connect

    Slate, S.C.; Ross, W.A.; Partain, W.L.

    1981-09-01

    This report presents technical data and performance characteristics of a high-level waste glass and canister intended for use in the design of a complete waste encapsulation package suitable for disposal in a geologic repository. The borosilicate glass contained in the stainless steel canister represents the probable type of high-level waste product that will be produced in a commercial nuclear-fuel reprocessing plant. Development history is summarized for high-level liquid waste compositions, waste glass composition and characteristics, and canister design. The decay histories of the fission products and actinides (plus daughters) calculated by the ORIGEN-II code are presented.

  16. Diagnostic reference levels for medical exposure of patients: ICRP guidance and related ICRU quantities.

    PubMed

    Rosenstein, Marvin

    2008-11-01

    In Publication 60 of the International Commission on Radiological Protection reference levels were described as values of measured quantities at which some specified action or decision should be taken. One particular form of reference level, the diagnostic reference level, applies specifically to medical exposure of patients. The objective of a diagnostic reference level is to help avoid radiation dose to the patient that does not contribute to the clinical purpose of a medical imaging task. This is accomplished by comparison between the numerical value of the diagnostic reference level and the mean or other appropriate value observed in practice for a suitable reference group of patients or a suitable reference phantom. A diagnostic reference level is not applied to individual patients. Diagnostic reference levels have no direct linkage to the numerical values for dose limits or dose constraints, and it is inappropriate to use them for regulatory or commercial purposes. Diagnostic reference levels should be selected by professional medical bodies (often in conjunction with health and radiation protection authorities) and their values may be specific to a country or region. A diagnostic reference level can be used: (1) to improve a regional, national or local distribution of observed results for a general medical imaging task, by reducing the frequency of unjustified high or low values; (2) to promote attainment of a narrower range of values that represent good practice for a more specific medical imaging task; or (3) to promote attainment of an optimum range of values for a specified medical imaging protocol. Authorized bodies are encouraged to set diagnostic reference levels that best meet their specific needs and that are consistent for the regional, national or local area to which they apply. Report 74 of the International Commission on Radiation Units and Measurements includes a commentary regarding quantities useful in establishing diagnostic reference levels

  17. Forget the Desk Job: Current Roles and Responsibilities in Entry-Level Reference Job Advertisements

    ERIC Educational Resources Information Center

    Detmering, Robert; Sproles, Claudene

    2012-01-01

    This study examines the evolving roles and responsibilities of entry-level academic reference positions, as stated in recent job advertisements posted on the American Library Association's JobLIST Web site and other sources. Findings from a content analysis of these advertisements indicate that current entry-level reference positions in academic…

  18. FDTD analysis of human body-core temperature elevation due to RF far-field energy prescribed in the ICNIRP guidelines

    NASA Astrophysics Data System (ADS)

    Hirata, Akimasa; Asano, Takayuki; Fujiwara, Osamu

    2007-08-01

    This study investigated the relationship between the specific absorption rate and temperature elevation in an anatomically-based model named NORMAN for exposure to radio-frequency far fields in the ICNIRP guidelines (1998 Health Phys. 74 494-522). The finite-difference time-domain method is used for analyzing the electromagnetic absorption and temperature elevation in NORMAN. In order to consider the variability of human thermoregulation, parameters for sweating are derived and incorporated into a conventional sweating formula. First, we investigated the effect of blood temperature variation modeling on body-core temperature. The computational results show that the modeling of blood temperature variation was the dominant factor influencing the body-core temperature. This is because the temperature in the inner tissues is elevated via the circulation of blood whose temperature was elevated due to EM absorption. Even at different frequencies, the body-core temperature elevation at an identical whole-body average specific absorption rate (SAR) was almost the same, suggesting the effectiveness of the whole-body average SAR as a measure in the ICNIRP guidelines. Next, we discussed the effect of sweating on the temperature elevation and thermal time constant of blood. The variability of temperature elevation caused by the sweating rate was found to be 30%. The blood temperature elevation at the basic restriction in the ICNIRP guidelines of 0.4 W kg-1 is 0.25 °C even for a low sweating rate. The thermal time constant of blood temperature elevation was 23 min and 52 min for a man with a lower and a higher sweating rate, respectively, which is longer than the average time of the SAR in the ICNIRP guidelines. Thus, the whole-body average SAR required for blood temperature elevation of 1 °C was 4.5 W kg-1 in the model of a human with the lower sweating coefficients for 60 min exposure. From a comparison of this value with the basic restriction in the ICNIRP guidelines of 0

  19. Beyond Orientation: The Roles of Senior Librarians in Training Entry-Level Reference Colleagues.

    ERIC Educational Resources Information Center

    Nofsinger, Mary M.; Lee, Angela S. W.

    1994-01-01

    Explores ways in which senior academic librarians contribute to the long-term educational, professional, collegial, and career development of entry-level reference librarians. Literature on reference training is reviewed; and four roles of senior librarians are described, including teacher, advisor, interpersonal role model, and mentor. (Contains…

  20. Hearing Tests on Mobile Devices: Evaluation of the Reference Sound Level by Means of Biological Calibration

    PubMed Central

    Kipiński, Lech; Grysiński, Tomasz; Kręcicki, Tomasz

    2016-01-01

    Background Hearing tests carried out in home setting by means of mobile devices require previous calibration of the reference sound level. Mobile devices with bundled headphones create a possibility of applying the predefined level for a particular model as an alternative to calibrating each device separately. Objective The objective of this study was to determine the reference sound level for sets composed of a mobile device and bundled headphones. Methods Reference sound levels for Android-based mobile devices were determined using an open access mobile phone app by means of biological calibration, that is, in relation to the normal-hearing threshold. The examinations were conducted in 2 groups: an uncontrolled and a controlled one. In the uncontrolled group, the fully automated self-measurements were carried out in home conditions by 18- to 35-year-old subjects, without prior hearing problems, recruited online. Calibration was conducted as a preliminary step in preparation for further examination. In the controlled group, audiologist-assisted examinations were performed in a sound booth, on normal-hearing subjects verified through pure-tone audiometry, recruited offline from among the workers and patients of the clinic. In both the groups, the reference sound levels were determined on a subject’s mobile device using the Bekesy audiometry. The reference sound levels were compared between the groups. Intramodel and intermodel analyses were carried out as well. Results In the uncontrolled group, 8988 calibrations were conducted on 8620 different devices representing 2040 models. In the controlled group, 158 calibrations (test and retest) were conducted on 79 devices representing 50 models. Result analysis was performed for 10 most frequently used models in both the groups. The difference in reference sound levels between uncontrolled and controlled groups was 1.50 dB (SD 4.42). The mean SD of the reference sound level determined for devices within the same model

  1. Levelized Cost of Energy Analysis of Marine and Hydrokinetic Reference Models: Preprint

    SciTech Connect

    Jenne, D. S.; Yu, Y. H.; Neary, V.

    2015-04-24

    In 2010 the U.S. Department of Energy initiated the development of six marine energy converter reference models. The reference models are point designs of well-known marine energy converters. Each device was designed to operate in a specific marine resource, instead of a generic device that can be deployed at any location. This method allows each device to be used as a benchmark for future reference model to benchmark future devices. The six designs consist of three current energy converters and three wave energy converters. The reference model project has generated both technical and economic data sets that are available in the public domain. The methodology to calculate the levelized cost of energy for the reference model project and an overall comparison of the cost of energy from these six reference-model designs are presented in this paper.

  2. Survey of ELF magnetic field levels in households near overhead power lines in Serbia.

    PubMed

    Vulevic, B; Osmokrovic, P

    2011-06-01

    During the last eight years, 'VINČA' Institute--Radiation and Environmental Protection Laboratory has performed environmental 'spot' broadband measurements of extremely low frequency (ELF-50 Hz) electric and magnetic fields and RF (100 kHz-3 GHz) electromagnetic fields in over 35 municipalities in Serbia. These investigations were motivated by the local population requesting information about levels of general public exposure to time-varying electric and magnetic fields in living spaces. This paper presents a summary of values measured in households under overhead power lines. These measurements will be useful in determining the exposure levels of the general public, which in turn determines whether the exposure levels are within reference levels recommended by International Commission on Non-Ionizing Radiation Protection (ICNIRP) Guidelines. It has turned out that measured values are far below the recommended safe levels. PMID:21273197

  3. Defining Top-of-Atmosphere Flux Reference Level for Earth Radiation Budget Studies

    NASA Technical Reports Server (NTRS)

    Loeb, N. G.; Kato, S.; Wielicki, B. A.

    2002-01-01

    To estimate the earth's radiation budget at the top of the atmosphere (TOA) from satellite-measured radiances, it is necessary to account for the finite geometry of the earth and recognize that the earth is a solid body surrounded by a translucent atmosphere of finite thickness that attenuates solar radiation differently at different heights. As a result, in order to account for all of the reflected solar and emitted thermal radiation from the planet by direct integration of satellite-measured radiances, the measurement viewing geometry must be defined at a reference level well above the earth s surface (e.g., 100 km). This ensures that all radiation contributions, including radiation escaping the planet along slant paths above the earth s tangent point, are accounted for. By using a field-of- view (FOV) reference level that is too low (such as the surface reference level), TOA fluxes for most scene types are systematically underestimated by 1-2 W/sq m. In addition, since TOA flux represents a flow of radiant energy per unit area, and varies with distance from the earth according to the inverse-square law, a reference level is also needed to define satellite-based TOA fluxes. From theoretical radiative transfer calculations using a model that accounts for spherical geometry, the optimal reference level for defining TOA fluxes in radiation budget studies for the earth is estimated to be approximately 20 km. At this reference level, there is no need to explicitly account for horizontal transmission of solar radiation through the atmosphere in the earth radiation budget calculation. In this context, therefore, the 20-km reference level corresponds to the effective radiative top of atmosphere for the planet. Although the optimal flux reference level depends slightly on scene type due to differences in effective transmission of solar radiation with cloud height, the difference in flux caused by neglecting the scene-type dependence is less than 0.1%. If an inappropriate

  4. Nature of Environmental Education in Bangladesh: A School Level Assessment with Reference to the National Curriculum

    ERIC Educational Resources Information Center

    Chowdhury, M. A. Taiyeb

    2014-01-01

    This paper attempts to identify the nature of formal environmental education in Bangladesh at school level with particular reference to the national curriculum. The main objective of the study is to assess the contents of the school textbooks for each standard, and to see whether the diversified themes covered are a good representation of…

  5. Measurement of the weighted peak level for occupational exposure to gradient magnetic fields for 1.5 and 3 Tesla MRI body scanners.

    PubMed

    Bonutti, F; Tecchio, M; Maieron, M; Trevisan, D; Negro, C; Calligaris, F

    2016-03-01

    The purpose of this work is to give a contribution to the construction of a comprehensive knowledge of the exposure levels to gradient magnetic fields (GMF) in terms of the weighed peak (WP), especially for 3 Tesla scanners for which there are still few works available in the literature. A new generation probe for the measurement of electromagnetic fields in the range of 1 Hz-400 kHz was used to assess the occupational exposure levels to the GMF for 1.5 and 3.0 Tesla MRI body scanners, using the method of the WP according to the International Commission on Non-Ionizing Radiation Protection (ICNIRP) approach. The probe was placed at a height of 1.1 m, close to the MRI scanners, where operators could stay during some medical procedures with particular issues. The measurements were performed for a set of typical acquisition sequences for body (liver) and head exams. The measured values of WP were in compliance with ICNIRP 2010 reference levels for occupational exposures.

  6. The Influence of the Terrestrial Reference Frame on Studies of Sea Level Change

    NASA Astrophysics Data System (ADS)

    Nerem, R. S.; Bar-Sever, Y. E.; Haines, B. J.; Desai, S.; Heflin, M. B.

    2015-12-01

    The terrestrial reference frame (TRF) provides the foundation for the accurate monitoring of sea level using both ground-based (tide gauges) and space-based (satellite altimetry) techniques. For the latter, tide gauges are also used to monitor drifts in the satellite instruments over time. The accuracy of the terrestrial reference frame (TRF) is thus a critical component for both types of sea level measurements. The TRF is central to the formation of geocentric sea-surface height (SSH) measurements from satellite altimeter data. The computed satellite orbits are linked to a particular TRF via the assumed locations of the ground-based tracking systems. The manner in which TRF errors are expressed in the orbit solution (and thus SSH) is not straightforward, and depends on the models of the forces underlying the satellite's motion. We discuss this relationship, and provide examples of the systematic TRF-induced errors in the altimeter derived sea-level record. The TRF is also crucial to the interpretation of tide-gauge measurements, as it enables the separation of vertical land motion from volumetric changes in the water level. TRF errors affect tide gauge measurements through GNSS estimates of the vertical land motion at each tide gauge. This talk will discuss the current accuracy of the TRF and how errors in the TRF impact both satellite altimeter and tide gauge sea level measurements. We will also discuss simulations of how the proposed Geodetic Reference Antenna in SPace (GRASP) satellite mission could reduce these errors and revolutionize how reference frames are computed in general.

  7. Reference levels in the context of Fukushima and related lessons learned.

    PubMed

    Sakai, Kazuo

    2013-11-01

    About 1 mo after the Fukushima Dai-ichi nuclear power plant accident, which was caused by the Great East Japan earthquake and tsunami on 11 March 2011, Japanese authorities set a dose criterion for the use of school playgrounds in Fukushima at 20 mSv y⁻¹ based on the International Commission on Radiological Protection recommendation for the reference level for the public under the existing exposure situation. This dose criterion was intended as a start line for reducing the dose to children; however, it caused much confusion among the public due to the misunderstanding of the concept of optimization and the application of reference level. Also, concerns were caused by the lack of precise but understandable information on radiation effects. This situation highlighted the importance of an understanding of radiation protection concepts by members of the general public and the outreach activities of radiation protection experts, both of which are essential for Fukushima recovery. PMID:24077049

  8. Mean glandular dose in six digital mammography services in Santiago, Chile: preliminary reference levels.

    PubMed

    Leyton, Fernando; Nogueira, Maria Do Socorro; Dantas, Marcelino; Duran, Maria Paz; Ubeda, Carlos

    2015-07-01

    The purpose of this paper was to estimate mean glandular dose levels (DG) in six digital mammography systems in Santiago, Chile, and to propose preliminary reference levels to execute mammography in Chile. The study was carried out assessing two direct digital systems and four computer-based radiography (CR) systems. Estimates of DG were calculated for different thicknesses of polymethyl methacrylate according to the quality control protocol in digital mammography of the Spanish Society of Medical Physics and NHSBSP Equipment Report 0604 Version 3. DG values ranged between 0.64 and 7.26 mGy for a range of 20- to 70-mm thickness, respectively. Thirty-six per cent of DG was higher than the acceptable dose level and 100 % of DG was higher than the desirable level. It is therefore necessary to optimise doses. The initial proposal to establish dose reference levels for DG would range between 0.90 and 6.40 mGy for a thickness range of 20 to 70 mm.

  9. Age-specific reference values for serum FSH and estradiol levels throughout the reproductive period.

    PubMed

    Grisendi, Valentina; Spada, Elena; Argento, Cindy; Plebani, Maddalena; Milani, Silvano; Seracchioli, Renato; Volpe, Annibale; La Marca, Antonio

    2014-06-01

    High serum day 3 FSH levels are associated with poor ovarian reserve and reduced fertility, but the interpretation of FSH values according to age is still not univocal. The purpose of this study was to determine age-dependent reference values in women with regular menstrual cycles and FSH as a guide for specialists. The study was performed at the Department of Mother-Infant of a University-based tertiary care centre. One-hundred ninety-two healthy normal menstruating women were recruited for the study. All patients attended the department on menstrual cycle day 3 for a blood sample for FSH and estradiol determination. A linear relationship between FSH or estradiol serum levels and age was observed. The FSH level increased by 0.11 IU for every year of age (1 IU for every 9 years of age). The values of FSH and estradiol corresponding to the 5th, 25th, 50th, 75th, 95th centiles for any specific age have been calculated. Serum FSH levels need to be interpreted according to age-dependent reference values. Serum FSH levels on 95th centile for any age may represent a warning sign for reduced ovarian reserve.

  10. Reference design and operations for deep borehole disposal of high-level radioactive waste.

    SciTech Connect

    Herrick, Courtney Grant; Brady, Patrick Vane; Pye, Steven; Arnold, Bill Walter; Finger, John Travis; Bauer, Stephen J.

    2011-10-01

    A reference design and operational procedures for the disposal of high-level radioactive waste in deep boreholes have been developed and documented. The design and operations are feasible with currently available technology and meet existing safety and anticipated regulatory requirements. Objectives of the reference design include providing a baseline for more detailed technical analyses of system performance and serving as a basis for comparing design alternatives. Numerous factors suggest that deep borehole disposal of high-level radioactive waste is inherently safe. Several lines of evidence indicate that groundwater at depths of several kilometers in continental crystalline basement rocks has long residence times and low velocity. High salinity fluids have limited potential for vertical flow because of density stratification and prevent colloidal transport of radionuclides. Geochemically reducing conditions in the deep subsurface limit the solubility and enhance the retardation of key radionuclides. A non-technical advantage that the deep borehole concept may offer over a repository concept is that of facilitating incremental construction and loading at multiple perhaps regional locations. The disposal borehole would be drilled to a depth of 5,000 m using a telescoping design and would be logged and tested prior to waste emplacement. Waste canisters would be constructed of carbon steel, sealed by welds, and connected into canister strings with high-strength connections. Waste canister strings of about 200 m length would be emplaced in the lower 2,000 m of the fully cased borehole and be separated by bridge and cement plugs. Sealing of the upper part of the borehole would be done with a series of compacted bentonite seals, cement plugs, cement seals, cement plus crushed rock backfill, and bridge plugs. Elements of the reference design meet technical requirements defined in the study. Testing and operational safety assurance requirements are also defined. Overall

  11. Arterial blood gas reference values for sea level and an altitude of 1,400 meters.

    PubMed

    Crapo, R O; Jensen, R L; Hegewald, M; Tashkin, D P

    1999-11-01

    Blood gas measurements were collected on healthy lifetime nonsmokers at sea level (n = 96) and at an altitude of 1,400 meters (n = 243) to establish reference equations. At each study site, arterial blood samples were analyzed in duplicate on two separate blood gas analyzers and CO-oximeters. Arterial blood gas variables included Pa(O(2)), Pa(CO(2)), pH, and calculated alveolar-arterial PO(2) difference (AaPO(2)). CO-oximeter variables were Hb, COHb, MetHb, and Sa(O(2)). Subjects were 18 to 81 yr of age with 166 male and 173 female. Outlier data were excluded from multiple regression analysis, and reference equations were fitted to the data in two ways: (1) best fit using linear, squared, and cross-product terms; (2) simple equations, including only the variables that explained at least 3% of the variance. Two sets of equations were created: (1) using only the sea level data and (2) using the combined data with barometric pressure as an independent variable. Comparisons with earlier studies revealed small but significant differences; the decline in Pa(O(2)) with age at each altitude was consistent with most previous studies. At sea level, the equation that included barometric pressure predicted Pa(O(2)) slightly better than the sea level specific equation. The inclusion of barometric pressure in the equations allows better prediction of blood gas reference values at sea level and at altitudes as high as 1,400 meters. PMID:10556115

  12. Reference values and action levels of biological monitoring in occupational exposure.

    PubMed

    Ong, C N

    1999-09-01

    The primary objectives of biological monitoring are (1) to prevent health impairment, (2) to assist in the assessment of risk, and (3) to evaluate the effectiveness of environmental controls. An efficient way to achieve these objectives would be to enforce the compliance of biological exposure standards at the workplace. However, biological monitoring should be viewed in the total context of control and prevention of work-related diseases, and not merely to comply with permissible standards. Biological monitoring depends very much on the conditions that the chemical is absorbed and how it is metabolised. Genetic diversity could therefore contribute to significant differences in this aspect. Furthermore, many of the reference values established have so far not been fully validated and therefore their usefulness is rather limited. This paper reviews and illustrates using some recent findings to show that biological reference values are influenced not just by the above mentioned issues, but also factors such as (1) health and nutritional status of the exposed population, (2) social and cultural factors, and (3) climatic conditions. Caution has to be taken when considering having an action level for some of the biological reference value. Biological reference values set without considering people, technology, and working conditions would be fraught with difficulties in implementation. PMID:10511254

  13. Benchmark dose estimation of cadmium reference level for hypertension in a Chinese population.

    PubMed

    Chen, Xiao; Wang, Zhongqiu; Zhu, Guoying; Liang, Yihuai; Jin, Taiyi

    2015-01-01

    Cadmium exposure can cause high blood pressure or hypertension. Benchmark dose has been used to estimate the reference point of cadmium for kidney and bone damage. In this study, we observed the association of blood pressure and cadmium in blood (BCd) and evaluated the reference level of cadmium for hypertension using benchmark dose (BMD) approach. A total of 441 subjects were included in this study. Blood samples were collected from each individual for BCd determination. Blood pressure was measured by electronic sphygmomanometer. BMD and BMDL were calculated using BMD software corresponding to additional risk of 10%. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and prevalence of hypertension increased with the increasing of BCd, especially for SBP (χ(2)=3.9, p=0.047 in men; χ(2)=4.3, p=0.037 in women). With a benchmark response of 10%, the BMDL10 for hypertension (high SBP) was 0.95μg/L and 1.02μg/L for women and men, respectively; the BMDL10 for hypertension (high DBP) was 1.8μg/L and 1.66μg/L for women and men, respectively. Our data evidenced that BCd was associated with elevation in blood pressure and hypertension, especially for women. The reference level of cadmium for hypertension with high SBP was lower than that of high DBP.

  14. A comparison and cross-reference of commercial low-level radioactive waste acceptance criteria

    SciTech Connect

    Kerr, T.A.

    1997-04-01

    This document, prepared by the National Low-Level Waste Management Program at the Idaho National Engineering and Environmental Laboratory, is a comparison and cross-reference of commercial low-level radioactive waste acceptance criteria. Many of these are draft or preliminary criteria as well as implemented criteria at operating low-level radioactive waste management facilities. Waste acceptance criteria from the following entities are included: US Nuclear Regulatory Commission, South Carolina, Washington, Utah, Nevada, California, illinois, Texas, North Carolina, Nebraska, Pennsylvania, New York, and the Midwest Compact Region. Criteria in the matrix include the following: physical form, chemical form, liquid limits, void space in packages, concentration averaging, types of packaging, chelating agents, solidification media, stability requirements, sorptive media, gas, oil, biological waste, pyrophorics, source material, special nuclear material, package dimensions, incinerator ash, dewatered resin, transuranics, and mixed waste. Each criterion in the matrix is cross-referenced to its source document so that exact requirements can be determined.

  15. Technology, Safety and Costs of Decommissioning a Reference Low-Level Waste Burial Ground. Appendices

    SciTech Connect

    1980-06-01

    Safety and cost information are developed for the conceptual decommissioning of commercial low-level waste (LLW) burial grounds. Two generic burial grounds, one located on an arid western site and the other located on a humid eastern site, are used as reference facilities for the study. The two burial grounds are assumed to have the same site capacity for waste, the same radioactive waste inventory, and similar trench characteristics and operating procedures. The climate, geology. and hydrology of the two sites are chosen to be typical of real western and eastern sites. Volume 2 (Appendices) contains the detailed analyses and data needed to support the results given in Volume 1.

  16. Technology, Safety and Costs of Decommissioning a Reference Low-Level Waste Burial Ground. Main Report

    SciTech Connect

    Murphy, E. S.; Holter, G. M.

    1980-06-01

    Safety and cost information are developed for the conceptual decommissioning of commercial low-level waste (LLW) burial grounds. Two generic burial grounds, one located on an arid western site and the other located on a humid eastern site, are used as reference facilities for the study. The two burial grounds are assumed to have the same site capacity for waste, the same radioactive waste inventory, and similar trench characteristics and operating procedures. The climate, geology. and hydrology of the two sites are chosen to be typical of real western and eastern sites. Volume 1 (Main Report) contains background information and study results in summary form.

  17. Effect of light level on the reference frames of visual motion processing.

    PubMed

    Yoshimoto, Sanae; Uchida-Ota, Mariko; Takeuchi, Tatsuto

    2014-01-01

    It is empirically known that some action-related visual tasks, which may rely on the construction of spatiotopic coordinates, are not well conducted under mesopic vision. The aim of this study was to clarify the effect of light level on the reference frame, such as retinotopic and spatiotopic coordinate bases, associated with visual motion processing. For this purpose, we used a phenomenon called visual motion priming in which the perceived direction of a directionally ambiguous test stimulus is influenced by the moving direction of a priming stimulus. Previous studies have shown that negative and positive motion priming are conspicuously observed in retinotopic and spatiotopic coordinates, respectively. In the experiments, participants made a saccade after the termination of the priming stimulus and judged the perceived direction of the test stimulus presented subsequently in retinotopic or spatiotopic coordinates at different light levels. We found that in retinotopic coordinates, negative motion priming was observed at all light levels. In spatiotopic coordinates, positive motion priming was observed at photopic and scotopic light levels, whereas the strength of motion priming was greatly reduced at mesopic light levels. These results were robust to the change in the luminance contrast or the saccadic eye movement per se. Different spatiotemporal properties of cones and rods at mesopic light levels may disturb the construction of a spatiotopic representation of motion, which leads to the disappearance of visual motion priming in spatiotopic coordinates during mesopic vision. PMID:25378370

  18. Effect of light level on the reference frames of visual motion processing.

    PubMed

    Yoshimoto, Sanae; Uchida-Ota, Mariko; Takeuchi, Tatsuto

    2014-01-01

    It is empirically known that some action-related visual tasks, which may rely on the construction of spatiotopic coordinates, are not well conducted under mesopic vision. The aim of this study was to clarify the effect of light level on the reference frame, such as retinotopic and spatiotopic coordinate bases, associated with visual motion processing. For this purpose, we used a phenomenon called visual motion priming in which the perceived direction of a directionally ambiguous test stimulus is influenced by the moving direction of a priming stimulus. Previous studies have shown that negative and positive motion priming are conspicuously observed in retinotopic and spatiotopic coordinates, respectively. In the experiments, participants made a saccade after the termination of the priming stimulus and judged the perceived direction of the test stimulus presented subsequently in retinotopic or spatiotopic coordinates at different light levels. We found that in retinotopic coordinates, negative motion priming was observed at all light levels. In spatiotopic coordinates, positive motion priming was observed at photopic and scotopic light levels, whereas the strength of motion priming was greatly reduced at mesopic light levels. These results were robust to the change in the luminance contrast or the saccadic eye movement per se. Different spatiotemporal properties of cones and rods at mesopic light levels may disturb the construction of a spatiotopic representation of motion, which leads to the disappearance of visual motion priming in spatiotopic coordinates during mesopic vision.

  19. 88Sr+ 445-THz Single-Ion Reference at the 10-17 Level

    NASA Astrophysics Data System (ADS)

    Madej, Alan

    2013-05-01

    We report experiments and precision measurements on a trapped and laser cooled single ion of 88Sr+ which when probed on the narrow 5 s 2S1/2 - 4 d 2D5/2 transition at 445-THz (674 nm) provides a reference yielding an evaluated fractional inaccuracy of 2.3 × 10-17 and which significantly outperforms the current realization of the SI second. The extremely low systematic shifts obtained are a result of our ability to evaluate, control and in some instances cancel some of the main perturbations that the trapped ion experiences. The fractional uncertainty on the micromotion induced shifts of the trapped ion has been evaluated to better than 1 × 10-18. This is achieved by minimizing any spurious displacement of the ion from trap center using DC trim electrodes and operating the system at a ``magic'' trap frequency where there is anti-correlation between the micromotion induced second order Doppler and Stark shifts resulting in near complete cancellation of this form of perturbation. The electrical quadrupole shift seen in many trapped ion systems is reduced to the 10-19 level by averaging the measured shifts of several pairs of Zeeman components. As in many optical frequency references, the dominant source of uncertainty arises from the blackbody radiation shift. We have been able to reduce the uncertainties associated by this shift using a recent theoretical evaluation of the differential scalar polarizability of the reference transition together with experimental measurements of the trap heating behavior and modeling of the blackbody field at the ion location. The present measurements are performed with resolution of spectral features down to the 4 Hz level (1 part in 1014) together with continuous measurement periods exceeding a few days allowing the possibility for the device to be used as an optical atomic time standard. As part of the effort to link this ultra accurate standard with current time/frequency standards, an absolute frequency measurement of the

  20. Assessment of potential risk levels associated with U.S. Environmental Protection Agency reference values.

    PubMed Central

    Castorina, Rosemary; Woodruff, Tracey J

    2003-01-01

    The U.S. Environmental Protection Agency (U.S. EPA) generally uses reference doses (RfDs) or reference concentrations (RfCs) to assess risks from exposure to toxic substances for noncancer health end points. RfDs and RfCs are supposed to represent lifetime inhalation or ingestion exposure with minimal appreciable risk, but they do not include information about the estimated risk from exposures equal to the RfD/RfC. We used results from benchmark dose modeling approaches recently adopted for use in developing RfDs/RfCs to estimate the risk levels associated with exposures at the RfD/RfC. We searched the U.S. EPA Integrated Risk Information System (IRIS) database and identified 11 chemicals with oral RfDs and 12 chemicals with inhalation RfCs that used benchmark dose modeling. For assessments with sufficient model information, we found that 16 of 21 (76%) of the dose-response models were linear or supralinear. We estimated the risk from exposures at the established RfDs and RfCs for these chemicals using a linear dose-response curve to characterize risk below the observed data. Risk estimates ranged from 1 in 10,000 to 5 in 1,000 for exposures at the RfDs, and from 1 in 10,000 to 3 in 1,000 for exposures at the RfCs. Risk estimates for exposures at the RfD/RfC values derived from sublinear dose-response curves ranged from 3 in 1,000,000,000 to 8 in 10,000. Twenty-four percent of reference values corresponded to estimated risk levels greater than 1 in 1,000; 10 of 14 assessments had points of departure greater than the no-observed-adverse-effect levels. For policy development regarding management of cancer risks, the U.S. EPA often uses 1 in 1,000,000 as a de minimis risk level. Although noncancer outcomes may in some instances be reversible and considered less severe than cancer, our findings call into question the assumption that established RfD and RfC values represent negligibly small risk levels. PMID:12896853

  1. Assessment of potential risk levels associated with U.S. Environmental Protection Agency reference values.

    PubMed

    Castorina, Rosemary; Woodruff, Tracey J

    2003-08-01

    The U.S. Environmental Protection Agency (U.S. EPA) generally uses reference doses (RfDs) or reference concentrations (RfCs) to assess risks from exposure to toxic substances for noncancer health end points. RfDs and RfCs are supposed to represent lifetime inhalation or ingestion exposure with minimal appreciable risk, but they do not include information about the estimated risk from exposures equal to the RfD/RfC. We used results from benchmark dose modeling approaches recently adopted for use in developing RfDs/RfCs to estimate the risk levels associated with exposures at the RfD/RfC. We searched the U.S. EPA Integrated Risk Information System (IRIS) database and identified 11 chemicals with oral RfDs and 12 chemicals with inhalation RfCs that used benchmark dose modeling. For assessments with sufficient model information, we found that 16 of 21 (76%) of the dose-response models were linear or supralinear. We estimated the risk from exposures at the established RfDs and RfCs for these chemicals using a linear dose-response curve to characterize risk below the observed data. Risk estimates ranged from 1 in 10,000 to 5 in 1,000 for exposures at the RfDs, and from 1 in 10,000 to 3 in 1,000 for exposures at the RfCs. Risk estimates for exposures at the RfD/RfC values derived from sublinear dose-response curves ranged from 3 in 1,000,000,000 to 8 in 10,000. Twenty-four percent of reference values corresponded to estimated risk levels greater than 1 in 1,000; 10 of 14 assessments had points of departure greater than the no-observed-adverse-effect levels. For policy development regarding management of cancer risks, the U.S. EPA often uses 1 in 1,000,000 as a de minimis risk level. Although noncancer outcomes may in some instances be reversible and considered less severe than cancer, our findings call into question the assumption that established RfD and RfC values represent negligibly small risk levels.

  2. Establishment of multi-slice computed tomography (MSCT) reference level in Johor, Malaysia

    NASA Astrophysics Data System (ADS)

    Karim, M. K. A.; Hashim, S.; Bakar, K. A.; Muhammad, H.; Sabarudin, A.; Ang, W. C.; Bahruddin, N. A.

    2016-03-01

    Radiation doses from computed tomography (CT) are the highest and most hazardous compared to other imaging modalities. This study aimed to evaluate radiation dose in Johor, Malaysia to patients during computed tomography examinations of the brain, chest and abdomen and to establish the local diagnostic reference levels (DRLs) as are present with the current, state- of-art, multi-slice CT scanners. Survey forms were sent to five centres performing CT to obtain data regarding acquisition parameters as well as the dose information from CT consoles. CT- EXPO (Version 2.3.1, Germany) was used to validate the dose information. The proposed DRLs were indicated by rounding the third quartiles of whole dose distributions where mean values of CTDIw (mGy), CTDIvol (mGy) and DLP (mGy.cm) were comparable with other reference levels; 63, 63, and 1015 respectively for CT Brain; 15, 14, and 450 respectively for CT thorax and 16, 17, and 590 respectively for CT abdomen. The study revealed that the CT practice and dose output were revolutionised, and must keep up with the pace of introductory technology. We suggest that CTDIvol should be included in current national DRLs, as modern CTs are configured with a higher number of detectors and are independent of pitch factors.

  3. Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study.

    PubMed

    Korevaar, Tim I M; Steegers, Eric A P; de Rijke, Yolanda B; Schalekamp-Timmermans, Sarah; Visser, W Edward; Hofman, Albert; Jaddoe, Vincent W V; Tiemeier, Henning; Visser, Theo J; Medici, Marco; Peeters, Robin P

    2015-09-01

    Human chorionic gonadotropin (hCG) is a pregnancy hormone secreted by the placental synctiotrophoblast cell layer that has been linked to fetal growth and various placental, uterine and fetal functions. In order to investigate the effects of hCG on clinical endpoints, knowledge on reference range (RR) methodology and determinants of gestational hCG levels is crucial. Moreover, a better understanding of gestational hCG physiology can improve current screening programs and future clinical management. Serum total hCG levels were determined in 8195 women participating in the Generation R Study. Gestational age specific RRs using 'ultrasound derived gestational age' (US RRs) were calculated and compared with 'last menstrual period derived gestational age' (LMP RRs) and a model-based RR. We also investigated which pregnancy characteristics were associated with hCG levels. Compared to the US RRs, the LMP RRs were lower, most notably for the median and lower limit levels. No considerable differences were found between RRs calculated in the general population or in uncomplicated pregnancies only. Maternal smoking, BMI, parity, ethnicity, fetal gender, placental weight and hyperemesis gravidarum symptoms were associated with total hCG. We provide gestational RRs for total hCG and show that total hCG values and RR cut-offs during pregnancy vary depending on pregnancy dating methodology. This is likely due to the influence of hCG on embryonic growth, suggesting that ultrasound based pregnancy dating might be less reliable in women with high/low hCG levels. Furthermore, we identify different pregnancy characteristics that influence total hCG levels considerably and should therefore be accounted for in clinical studies.

  4. Reasoning in Reference Games: Individual- vs. Population-Level Probabilistic Modeling.

    PubMed

    Franke, Michael; Degen, Judith

    2016-01-01

    Recent advances in probabilistic pragmatics have achieved considerable success in modeling speakers' and listeners' pragmatic reasoning as probabilistic inference. However, these models are usually applied to population-level data, and so implicitly suggest a homogeneous population without individual differences. Here we investigate potential individual differences in Theory-of-Mind related depth of pragmatic reasoning in so-called reference games that require drawing ad hoc Quantity implicatures of varying complexity. We show by Bayesian model comparison that a model that assumes a heterogenous population is a better predictor of our data, especially for comprehension. We discuss the implications for the treatment of individual differences in probabilistic models of language use. PMID:27149675

  5. Recently revised diagnostic reference levels in nuclear medicine in Bulgaria and in Finland.

    PubMed

    Korpela, H; Bly, R; Vassileva, J; Ingilizova, K; Stoyanova, T; Kostadinova, I; Slavchev, A

    2010-01-01

    An EU twinning project entitled 'Strengthening of administrative structures for radiation protection and safe use of ionising radiation in diagnostics and therapy' was established between Bulgaria and Finland, lasting from June 2008 to May 2009. One component of the project was to improve the optimisation of patient protection in nuclear medicine (NM) through revising diagnostic reference levels (DRLs). The revised DRLs are based on national surveys on the numbers of NM procedures and activities given to the patients in different procedures. The survey in Bulgaria was carried out in 2008 and that in Finland in 2007. National DRLs were established for the most frequent and dose-relevant examinations. The proposed DRLs in both countries are in good agreement with other national recommendations in Europe.

  6. Low-level radioactive waste technology: a selected, annotated bibliography. [416 references

    SciTech Connect

    Fore, C.S.; Carrier, R.F.; Brewster, R.H.; Hyder, L.K.; Barnes, K.A.

    1981-10-01

    This annotated bibliography of 416 references represents the third in a series to be published by the Hazardous Materials Information Center containing scientific, technical, economic, and regulatory information relevant to low-level radioactive waste technology. The bibliography focuses on disposal site, environmental transport, and waste treatment studies as well as general reviews on the subject. The publication covers both domestic and foreign literature for the period 1951 to 1981. Major chapters selected are Chemical and Physical Aspects; Container Design and Performance; Disposal Site; Environmental Transport; General Studies and Reviews; Geology, Hydrology, and Site Resources; Regulatory and Economic Aspects; Social Aspects; Transportation Technology; Waste Production; and Waste Treatment. Entries in each of the chapters are further classified as a field study, laboratory study, theoretical study, or general overview involving one or more of these research areas.

  7. Reasoning in Reference Games: Individual- vs. Population-Level Probabilistic Modeling

    PubMed Central

    Franke, Michael; Degen, Judith

    2016-01-01

    Recent advances in probabilistic pragmatics have achieved considerable success in modeling speakers’ and listeners’ pragmatic reasoning as probabilistic inference. However, these models are usually applied to population-level data, and so implicitly suggest a homogeneous population without individual differences. Here we investigate potential individual differences in Theory-of-Mind related depth of pragmatic reasoning in so-called reference games that require drawing ad hoc Quantity implicatures of varying complexity. We show by Bayesian model comparison that a model that assumes a heterogenous population is a better predictor of our data, especially for comprehension. We discuss the implications for the treatment of individual differences in probabilistic models of language use. PMID:27149675

  8. [Influence of age on blood glucose levels: percentile reference intervals determined on ambulatory patients].

    PubMed

    Sapigni, T; Astolfi, G; Cavallini, L; Cremonini, F

    1981-06-15

    Data of routine chemical and hematological laboratory tests regarding outpatients were collected in four different hospitals of the provinces of Ferrara, Rovigo and Bologna. Data of about 1500 subjects per hospital were cumulated without preliminary selection of patients; sex, age and pregnancy status were also recorded. At the end of the collection, the second (and third) record of the same patient was discarded; only those referring to the first examination were retained. In this report we consider only the values of the blood sugar level which were obtained by enzymatic methods. Descriptive statistics and regression analysis were performed utilizing a CDC CYBER 70/76 computer. The means and the variances of the data collected at the four hospital laboratories were very similar (Tab 1). The interlaboratory analysis of variance was poorly significant. All frequency distributions were leptocurtic and skewed to the right (Fig. 1). The blood sugar level tend to increase with age (Tab. 2). This correlation is graphically depicted in a two-dimensional plot (Fig 2) in which the regression line and the 2, 5 and 97,5 percentile levels corrected for age were also reported. We think that this diagram may be more helpful to the clinicians interpreting laboratory results than the usual "normal values". PMID:7284101

  9. Derivation of Australian diagnostic reference levels for paediatric multi detector computed tomography.

    PubMed

    Hayton, Anna; Wallace, Anthony

    2016-09-01

    Australian National Diagnostic Reference Levels for paediatric multi detector computed tomography were established for three protocols, Head, Chest and AbdoPelvis, across two age groups, Baby/Infant 0-4 years and Child 5-14 years by the Australian Radiation Protection and Nuclear Safety Agency in 2012. The establishment of Australian paediatric DRLs is an important step towards lowering patient CT doses on a national scale. While Adult DRLs were calculated with data collected from the web based Australian National Diagnostic Reference Level Service, no paediatric data was submitted in the first year of service operation. Data from an independent Royal Australian and New Zealand College of Radiologists Quality Use of Diagnostic Imaging paediatric optimisation survey was used. The paediatric DRLs were defined for CTDIvol (mGy) and DLP (mGy·cm) values that referenced the 16 cm PMMA phantom for the Head protocol and the 32 cm PMMA phantom for body protocols for both paediatric age groups. The Australian paediatric DRLs for multi detector computed tomography are for the Head, Chest and AbdoPelvis protocols respectively, 470, 60 and 170 mGy·cm for the Baby/Infant age group, and 600, 110 and 390 mGy·cm for the Child age group. A comparison with published international paediatric DRLs for computed tomography reveal the Australian paediatric DRLs to be lower on average. However, the comparison is complicated by misalignment of defined age ranges. It is the intention of ARPANSA to review the paediatric DRLs in conjunction with a review of the adult DRLs, which should occur within 5 years of their publication. PMID:27350262

  10. Phylogenetic reference data for systematics and phylotaxonomy of arbuscular mycorrhizal fungi from phylum to species level.

    PubMed

    Krüger, Manuela; Krüger, Claudia; Walker, Christopher; Stockinger, Herbert; Schüssler, Arthur

    2012-03-01

    Although the molecular phylogeny, evolution and biodiversity of arbuscular mycorrhizal fungi (AMF) are becoming clearer, phylotaxonomically reliable sequence data are still limited. To fill this gap, a data set allowing resolution and environmental tracing across all taxonomic levels is provided. Two overlapping nuclear DNA regions, totalling c. 3 kb, were analysed: the small subunit (SSU) rRNA gene (up to 1800 bp) and a fragment spanning c. 250 bp of the SSU rDNA, the internal transcribed spacer (ITS) region (c. 475-520 bp) and c. 800 bp of the large subunit (LSU) rRNA gene. Both DNA regions together could be analysed for 35 described species, the SSU rDNA for c. 76 named and 18 as yet undefined species, and the ITS region or LSU rDNA, or a combination of both, for c. 91 named and 16 as yet undefined species. Present phylogenetic analyses, based on the three rDNA markers, provide reliable and robust resolution from phylum to species level. Altogether, 109 named species and 27 cultures representing as yet undefined species were analysed. This study provides a reference data set for molecular systematics and environmental community analyses of AMF, including analyses based on deep sequencing.

  11. Levels of seven urinary phthalate metabolites in a human reference population.

    PubMed Central

    Blount, B C; Silva, M J; Caudill, S P; Needham, L L; Pirkle, J L; Sampson, E J; Lucier, G W; Jackson, R J; Brock, J W

    2000-01-01

    Using a novel and highly selective technique, we measured monoester metabolites of seven commonly used phthalates in urine samples from a reference population of 289 adult humans. This analytical approach allowed us to directly measure the individual phthalate metabolites responsible for the animal reproductive and developmental toxicity while avoiding contamination from the ubiquitous parent compounds. The monoesters with the highest urinary levels found were monoethyl phthalate (95th percentile, 3,750 ppb, 2,610 microg/g creatinine), monobutyl phthalate (95th percentile, 294 ppb, 162 microg/g creatinine), and monobenzyl phthalate (95th percentile, 137 ppb, 92 microg/g creatinine), reflecting exposure to diethyl phthalate, dibutyl phthalate, and benzyl butyl phthalate. Women of reproductive age (20-40 years) were found to have significantly higher levels of monobutyl phthalate, a reproductive and developmental toxicant in rodents, than other age/gender groups (p < 0.005). Current scientific and regulatory attention on phthalates has focused almost exclusively on health risks from exposure to only two phthalates, di-(2-ethylhexyl) phthalate and di-isononyl phthalate. Our findings strongly suggest that health-risk assessments for phthalate exposure in humans should include diethyl, dibutyl, and benzyl butyl phthalates. PMID:11049818

  12. Global Reference Frame Realization on National Level Based on the Integration of National CORS Networks

    NASA Astrophysics Data System (ADS)

    Kenyeres, A.; Caporali, A.; Horvath, T.; Baron, A.; Doncker, F. D.; Droscak, B.; Duret, A.; Franke, P.; Georgiev, I.; Gianniou, M.; Hansen, D.; Huisman, L.; Morozova, K.; Nagl, J.; Pihlak, P.; Stangl, G.; Valdes, M.; Ryczywolski, M.; Zurutuza, J.

    2015-12-01

    The national permanent GNSS networks are not only serving the general surveying practice in real-time mode, but they are deployed at reference frame maintenance and geodynamic studies relying on their homogeneously analyzed long-term data series. The ongoing EPN (EUREF Permanent Network) densification targets the integration of the national CORS networks and a homogeneous, dense position and velocity product is derived using the EPN as backbone infrastructure. The homogeneous cumulative solution relies on the national weekly SINEX products in order to minimize inconsistencies (e.g. site naming, discontinuities). The integration is done with the CATREF software (Altamimi et al, IGN) using the Minimum Constraint approach. The derived position and velocity product will be an essential material for various geokinematic studies (PGR, intraplate and plate boundary zone investigations), and also for the better realization of ETRS89 over tectonically active regions. This work is very well inline with the goals of other European initiatives as EPOS and EUPOS. The preparatory work is well in progress, several years of weekly SINEX files are already available and analyzed. The database contains more than 2000 stations stemming from 15 contributing Analysis Centres. A significant effort is devoted to the cleaning and organization of the station metadata and publish on the EPNCB website, which is necessary to improve the quality and reliabilty of the combination product.This presentation, beyond the publication of the state-of the-art combination results partly focuses on the analysis of existing reference frame realization issues caused by the GNSS antenna PCV updates not yet eliminated on the national CORS level.

  13. Dose Assessment in Computed Tomography Examination and Establishment of Local Diagnostic Reference Levels in Mazandaran, Iran

    PubMed Central

    Janbabanezhad Toori, A.; Shabestani-Monfared, A.; Deevband, M.R.; Abdi, R.; Nabahati, M.

    2015-01-01

    Background Medical X-rays are the largest man-made source of public exposure to ionizing radiation. While the benefits of Computed Tomography (CT) are well known in accurate diagnosis, those benefits are not risk-free. CT is a device with higher patient dose in comparison with other conventional radiation procedures. Objective This study is aimed at evaluating radiation dose to patients from Computed Tomography (CT) examination in Mazandaran hospitals and defining diagnostic reference level (DRL). Methods Patient-related data on CT protocol for four common CT examinations including brain, sinus, chest and abdomen & pelvic were collected. In each center, Computed Tomography Dose Index (CTDI) measurements were performed using pencil ionization chamber and CT dosimetry phantom according to AAPM report No. 96 for those techniques. Then, Weighted Computed Tomography Dose Index (CTDIW), Volume Computed Tomography Dose Index (CTDI vol) and Dose Length Product (DLP) were calculated. Results The CTDIw for brain, sinus, chest and abdomen & pelvic ranged (15.6-73), (3.8-25. 8), (4.5-16.3) and (7-16.3), respectively. Values of DLP had a range of (197.4-981), (41.8-184), (131-342.3) and (283.6-486) for brain, sinus, chest and abdomen & pelvic, respectively. The 3rd quartile of CTDIW, derived from dose distribution for each examination is the proposed quantity for DRL. The DRLs of brain, sinus, chest and abdomen & pelvic are measured 59.5, 17, 7.8 and 11 mGy, respectively. Conclusion Results of this study demonstrated large scales of dose for the same examination among different centers. For all examinations, our values were lower than international reference doses. PMID:26688796

  14. Crustal Motion Geodesy, PGR and Sea Level Rise: Eliminating Reference Frame Effects

    NASA Astrophysics Data System (ADS)

    Bevis, M. G.; Brown, A. K.; Kendrick, E. C.; Caccamise, D. J.; Merrifield, M. A.

    2012-12-01

    Long-term geodetic observations of vertical crustal motion can be used to assess and constrain PGR models and to assess and constrain 'absolute' versus 'relative' rates of sea level change. All geodetic estimates for the vertical velocities of GPS stations are stated in a specific reference frame (RF). In effect, this RF provides a datum for the vertical velocity measurements. Geodesists have long known that two geodetic groups using fairly similar GPS data sets (in terms of station distribution and temporal extent) often fail to realize equivalent RFs, even when they agree, in principle, on the definition of their 'target' RF. This phenomenon has sometimes been referred to as 'RF realization error'. This problem becomes more pronounced as the spatial and temporal sampling of the GPS networks under analysis by two or more geodesy groups becomes more diverse. A similar phenomenon occurs with PGR models. Many PGR models are nominally posed in the same physical frame - usually a Center of Mass (CM) frame - but in practice the global vertical velocity fields they predict are quite distinct. We shall argue that part of this discrepancy arises from RF realization error. We shall argue that the best way to address the RF problem in the context of vertical velocities is to estimate a component of the global vertical velocity field (evaluated at a given set of stations) consistent with a constant rate of displacement between the two frames, and then remove this component so as to isolate differences that cannot be explained in terms of frame drift. In effect, the resulting set of vertical velocity differences is 'frameless'. We will argue that such frameless comparisons are much safer than imagining that any two groups (be they geodesists or GPR theorists) can ever realize exactly equivalent frames. The distinction between these two approaches is sometimes subtle, but in practice the frameless approach means we must estimate frame translation rates for each distinct

  15. SU-E-P-10: Establishment of Local Diagnostic Reference Levels of Routine Exam in Computed Tomography

    SciTech Connect

    Yeh, M; Wang, Y; Weng, H

    2015-06-15

    Introduction National diagnostic reference levels (NDRLs) can be used as a reference dose of radiological examination can provide radiation dose as the basis of patient dose optimization. Local diagnostic reference levels (LDRLs) by periodically view and check doses, more efficiency to improve the way of examination. Therefore, the important first step is establishing a diagnostic reference level. Computed Tomography in Taiwan had been built up the radiation dose limit value,in addition, many studies report shows that CT scan contributed most of the radiation dose in different medical. Therefore, this study was mainly to let everyone understand DRL’s international status. For computed tomography in our hospital to establish diagnostic reference levels. Methods and Materials: There are two clinical CT scanners (a Toshiba Aquilion and a Siemens Sensation) were performed in this study. For CT examinations the basic recommended dosimetric quantity is the Computed Tomography Dose Index (CTDI). Each exam each different body part, we collect 10 patients at least. Carried out the routine examinations, and all exposure parameters have been collected and the corresponding CTDIv and DLP values have been determined. Results: The majority of patients (75%) were between 60–70 Kg of body weight. There are 25 examinations in this study. Table 1 shows the LDRL of each CT routine examination. Conclusions: Therefore, this study would like to let everyone know DRL’s international status, but also establishment of computed tomography of the local reference levels for our hospital, and providing radiation reference, as a basis for optimizing patient dose.

  16. Multi-Component Molecular-Level Body Composition Reference Methods: Evolving Concepts and Future Directions

    PubMed Central

    Heymsfield, Steven B.; Ebbeling, Cara B.; Zheng, Jolene; Pietrobelli, Angelo; Strauss, Boyd J.; Silva, Analiza M.; Ludwig, David S.

    2015-01-01

    Excess adiposity is the main phenotypic feature that defines human obesity and that plays a pathophysiological role in most chronic diseases. Measuring the amount of fat mass present is thus a central aspect of studying obesity at the individual and population levels. Nevertheless, a consensus is lacking among investigators on a single accepted “reference” approach for quantifying fat mass in vivo. While the research community generally relies on the multicomponent body-volume class of “reference” models for quantifying fat mass, no definable guide discerns among different applied equations for partitioning the four (fat, water, protein, and mineral mass) or more quantified components, standardizes “adjustment” or measurement system approaches for model-required labeled water dilution volumes and bone mineral mass estimates, or firmly establishes the body temperature at which model physical properties are assumed. The resulting differing reference strategies for quantifying body composition in vivo leads to small but under some circumstances important differences in the amount of measured body fat. Recent technological advances highlight opportunities to expand model applications to new subject groups and measured components such as total body protein. The current report reviews the historical evolution of multicomponent body volume-based methods in the context of prevailing uncertainties and future potential. PMID:25645009

  17. Derivation of a reference dose and drinking water equivalent level for 1,2,3-trichloropropane.

    PubMed

    Tardiff, Robert G; Carson, M Leigh

    2010-06-01

    In some US potable water supplies, 1,2,3-trichloropropane (TCP) has been present at ranges of non-detect to less than 100 ppb, resulting from past uses. In subchronic oral studies, TCP produced toxicity in kidneys, liver, and other tissues. TCP administered by corn oil gavage in chronic studies produced tumors at multiple sites in rats and mice; however, interpretation of these studies was impeded by substantial premature mortality. Drinking water equivalent levels (DWELs) were estimated for a lifetime of consumption by applying biologically-based safety/risk assessment approaches, including Monte Carlo techniques, and with consideration of kinetics and modes of action, to possibly replace default assumptions. Internationally recognized Frameworks for human relevance of animal data were employed to interpret the findings. Calculated were a reference dose (=39 microg/kg d) for non-cancer and Cancer Values (CV) (=10-14 microg/kg d) based on non-linear dose-response relationships for mutagenicity as a precursor of cancer. Lifetime Average Daily Intakes (LADI) are 3130 and 790-1120 microg/person-d for non-cancer and cancer, respectively. DWELs, estimated by applying a relative source contribution (RSC) of 50% to the LADIs, are 780 and 200-280 microg/L for non-cancer and cancer, respectively. These DWELs may inform establishment of formal/informal guidelines and standards to protect public health. PMID:20303376

  18. Proposed preliminary diagnostic reference levels for three common interventional cardiology procedures in Ireland.

    PubMed

    D'Helft, C; McGee, A; Rainford, L; McFadden, S; Winder, J; Hughes, C; Brennan, P C

    2008-01-01

    This study has gathered data across Ireland to determine the range of radiation doses received during interventional cardiology (IC) investigations. Radiation doses for three common types of IC examinations where investigated: coronary angiography (CA), percutaneous coronary intervention (PCI) and pacemaker insertions (PPI). A total of 22 cardiac imaging suites participated in the study. Radiation dose was monitored for 1804 adult patients using dose area product (DAP) meters. Individual patient DAP values ranged from 136-23,101 cGy cm2, 475-41,038 cGy cm2 and 45-17,192 cGy cm2 for CA, PCI and PPI respectively, with third quartile values of 4654 cGy cm2, 10,650 cGy cm2 and 1686 cGy cm2. The importance of optimising radiation dose, while not compromising diagnostic efficacy is clear. Although setting reference levels for these complex procedures has some difficulties, it is important that some guideline values are available as a benchmark to guide the operators during these potentially high dose procedures. The third quartile values as described by this paper may offer such guidance.

  19. Advancing reference emission levels in subnational and national REDD+ initiatives: a CLASlite approach

    PubMed Central

    2015-01-01

    Conservation and monitoring of tropical forests requires accurate information on their extent and change dynamics. Cloud cover, sensor errors and technical barriers associated with satellite remote sensing data continue to prevent many national and sub-national REDD+ initiatives from developing their reference deforestation and forest degradation emission levels. Here we present a framework for large-scale historical forest cover change analysis using free multispectral satellite imagery in an extremely cloudy tropical forest region. The CLASlite approach provided highly automated mapping of tropical forest cover, deforestation and degradation from Landsat satellite imagery. Critically, the fractional cover of forest photosynthetic vegetation, non-photosynthetic vegetation, and bare substrates calculated by CLASlite provided scene-invariant quantities for forest cover, allowing for systematic mosaicking of incomplete satellite data coverage. A synthesized satellite-based data set of forest cover was thereby created, reducing image incompleteness caused by clouds, shadows or sensor errors. This approach can readily be implemented by single operators with highly constrained budgets. We test this framework on tropical forests of the Colombian Pacific Coast (Chocó) – one of the cloudiest regions on Earth, with successful comparison to the Colombian government’s deforestation map and a global deforestation map. PMID:25678933

  20. Out of Cite! How Reference Managers Are Taking Research to the Next Level

    ERIC Educational Resources Information Center

    Muldrow, Jason; Yoder, Stephen

    2009-01-01

    Times change, and so do research methods; gone are the days of researching with index cards. While academics may be slow to adopt emerging citation technology, the reference manager field is blazing ahead. This article explains what reference managers are, addresses their emergence in and potential impact on academe, and profiles a newcomer to the…

  1. SU-E-I-33: Establishment of CT Diagnostic Reference Levels in Province Nova Scotia

    SciTech Connect

    Tonkopi, E; Abdolell, M; Duffy, S

    2015-06-15

    Purpose: To evaluate patient radiation dose from the most frequently performed CT examinations and to establish provincial diagnostic reference levels (DRLs) as a tool for protocol optimization. Methods: The study investigated the following CT examinations: head, chest, abdomen/pelvis, and chest/abdomen/pelvis (CAP). Dose data, volume CT dose index (CTDIvol) and dose-length product (DLP), were collected from 15 CT scanners installed during 2004–2014 in 11 hospital sites of Nova Scotia. All scanners had dose modulation options and multislice capability (16–128 detector rows). The sample for each protocol included 15 average size patients (70±20 kg). Provincial DRLs were calculated as the 75th percentile of patient dose distributions. The differences in dose between hospitals were evaluated with a single factor ANOVA statistical test. Generalized linear modeling was used to determine the factors associated with higher radiation dose. A sample of 36 abdominal studies performed on three different scanners was blinded and randomized for an assessment by an experienced radiologist who graded the imaging quality of anatomic structures. Results: Data for 900 patients were collected. The DRLs were proposed using CTDIvol (mGy) and DLP (mGy*cm) values for CT head (67 and 1049, respectively), chest (12 and 393), abdomen/pelvis (16 and 717), and CAP (14 and 1034). These DRLs were lower than the published national data except for the head CTDIvol. The differences between the means of the dose distributions from each scanner were statistically significant (p<0.05) for all examinations. A very weak correlation was found between the dose and the scanner age or the number of slices with Pearson’s correlation coefficients of 0.011–0.315. The blinded analysis of image quality demonstrated no clinically significant difference except for the noise category. Conclusion: Provincial DRLs were established for typical CT examinations. The variations in dose between the hospitals

  2. Validation of reference genes for real-time quantitative PCR studies in gene expression levels of Lactobacillus casei Zhang.

    PubMed

    Zhao, Wenjing; Li, Yan; Gao, Pengfei; Sun, Zhihong; Sun, Tiansong; Zhang, Heping

    2011-09-01

    Lactobacillus casei Zhang, a potential probiotic strain isolated from homemade koumiss in Inner Mongolia of China, has been sequenced and deposited in GenBank. Real-time quantitative PCR is one of the most widely used methods to study related gene expression levels of Lactobacillus casei Zhang. For accurate and reliable gene expression analysis, normalization of gene expression data using one or more appropriate reference genes is essential. We used three statistical methods (geNorm, NormFinder, and BestKeeper) to evaluate the expression levels of five candidate reference genes (GAPD, gyrB, LDH, 16s rRNA, and recA) under different culture conditions and different growth phases to find a suitable housekeeping gene which can be used as internal standard. The results showed that the best reference gene was GAPD, and a set of two genes, GAPD and gyrB (which were the most stable reference genes), is recommended for normalization of real-time quantitative PCR experiments under all the different experimental conditions tested. The systematic validation of candidate reference genes is important for obtaining reliable analysis results of real-time quantitative PCR studies in gene expression levels of Lactobacillus casei Zhang. PMID:21104423

  3. 23 CFR Appendix A to Part 772 - National Reference Energy Mean Emission Levels as a Function of Speed

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false National Reference Energy Mean Emission Levels as a Function of Speed A Appendix A to Part 772 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Function of Speed EC14OC91.013...

  4. The Relationship Between Global Mean Sea Level Rise and the Reference Frame

    NASA Technical Reports Server (NTRS)

    Lemoine, F.; Luthcke, S.; Zelensky, N.; Pavlis, E.; Beckley, B.; Ray, R.; Petrov, L.; Pavlis, D.; Rowlands, D.

    2006-01-01

    The Terrestrial Reference Frame is the fundamental means by which we relate observations in space and time. For example, in order to generate a homogeneous and consistent time series of geo-referenced altimeter measurements over the span of the Topex/Poseidon and Jason-1 missions, we must examine carefully the role of improvements in measurement modelling, force modelling, and improved reference frame realizations. In this paper, we quantify the effects of improvements in force modelling, for example the use of new GRACE-derived gravity models, the effect of time-variable gravity derived from GRACE on altimeter satellite orbits. In addition, we examine the effects of modelling geocenter in altimeteric satellite POD, and look at how the application of atmospheric loading might affect the time-series of precise orbits for Topex/Poseidon and Jason-1.

  5. Analysis of ground tests of a microwave, earth-occultation, pressure-reference-level system.

    NASA Technical Reports Server (NTRS)

    Ungar, S. G.; Lusignan, B. B.

    1973-01-01

    A two-satellite, microwave, earth-occultation system can supplement an infrared sensor by providing an accurate altitude reference that will serve to fix, as a function of height, the derived temperature profile of the infrared sounder. The results of ground tests made in Hawaii to estimate the likely effects of scintillation and fading on an occultation system are described. It was found that the microwave signal suffered periods of intense fading; extensive computer analyses of the data were performed in which aircraft-generated refractivity profiles were subjected to ray tracing. Results of these analyses indicate that the probable cause of the observed fading was multipath, a low-altitude phenomenon usually attributed to water vapor inhomogeneities. It is maintained that multipath will therefore have minimal effect on the pressure-reference microwave occultation system, which would operate at a relatively high closest-approach altitude (about 8 km).

  6. Progress towards an alanine/ESR therapy level reference dosimetry service at NPL.

    PubMed

    Sharpe, P H; Rajendran, K; Sephton, J P

    1996-01-01

    This paper describes work being carried out at the National Physical Laboratory towards the establishment of an alanine reference dosimetry service for radiotherapy applications. A precision fused quartz holder has been constructed to allow precise positioning of alanine dosimeters in the ESR cavity. A novel method of signal analysis based on spectrum fitting has been developed to minimize the effect of baseline distortions. Data are also presented on the relative response of alanine to 60Co gamma rays and high energy photons (4-12 MeV).

  7. Parallel implementation of multireference coupled-cluster theories based on the reference-level parallelism

    SciTech Connect

    Brabec, Jiri; Pittner, Jiri; van Dam, Hubertus JJ; Apra, Edoardo; Kowalski, Karol

    2012-02-01

    A novel algorithm for implementing general type of multireference coupled-cluster (MRCC) theory based on the Jeziorski-Monkhorst exponential Ansatz [B. Jeziorski, H.J. Monkhorst, Phys. Rev. A 24, 1668 (1981)] is introduced. The proposed algorithm utilizes processor groups to calculate the equations for the MRCC amplitudes. In the basic formulation each processor group constructs the equations related to a specific subset of references. By flexible choice of processor groups and subset of reference-specific sufficiency conditions designated to a given group one can assure optimum utilization of available computing resources. The performance of this algorithm is illustrated on the examples of the Brillouin-Wigner and Mukherjee MRCC methods with singles and doubles (BW-MRCCSD and Mk-MRCCSD). A significant improvement in scalability and in reduction of time to solution is reported with respect to recently reported parallel implementation of the BW-MRCCSD formalism [J.Brabec, H.J.J. van Dam, K. Kowalski, J. Pittner, Chem. Phys. Lett. 514, 347 (2011)].

  8. Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites

    SciTech Connect

    Grainger, James . E-mail: jag2@cdc.gov; Huang, Wenlin; Patterson, Donald G.; Turner, Wayman E.; Pirkle, James; Caudill, Samuel P.; Wang, Richard Y.; Needham, Larry L.; Sampson, Eric J.

    2006-03-15

    We developed a gas chromatography isotope-dilution high-resolution mass spectrometry (GC/Id-HRMS) method for measuring 14 polycyclic aromatic hydrocarbon (PAH) metabolites representing seven parent PAHs in 3 mL of urine at low parts-per-trillion levels. PAH levels were determined in urine samples collected in 1999 and 2000 from approximately 2400 participants in the National Health and Nutrition Examination Survey, and, for the first time, reference range values were calculated for these metabolites in the US population. Using this GC/ID-HRMS method, we found detectable concentrations for monohydroxy metabolite isomers of fluorene, phenanthrene, fluoranthene, pyrene, and chrysene, benzo[c]phenanthrene, and benz[a]anthracene. Some monohydroxy metabolite isomers of benzo[c]phenanthrene, chrysene, and benz[a]anthracene exhibited low detection frequencies that did not allow for geometric mean calculations. Our study results enabled us to establish a reference range for the targeted PAHs in the general US population.

  9. DEVELOPMENT OF TOXICITY REFERENCE VALUES FOR ECOLOGICAL SOIL SCREENING LEVELS (ECO-SSLS) FOR TERRESTRIAL WILDLIFE

    EPA Science Inventory

    Ecological Soil Screening Levels (Eco-SSLs) protective of terrestrial wildlife were developed by the USEPA Superfund. The wildlife Eco-SSL is the soil contaminant concentration where the Effect Dose (TRV) and Exposure Dose are equal (amount of contaminant in the diet that is take...

  10. Centimeter-Level Robust Gnss-Aided Inertial Post-Processing for Mobile Mapping Without Local Reference Stations

    NASA Astrophysics Data System (ADS)

    Hutton, J. J.; Gopaul, N.; Zhang, X.; Wang, J.; Menon, V.; Rieck, D.; Kipka, A.; Pastor, F.

    2016-06-01

    For almost two decades mobile mapping systems have done their georeferencing using Global Navigation Satellite Systems (GNSS) to measure position and inertial sensors to measure orientation. In order to achieve cm level position accuracy, a technique referred to as post-processed carrier phase differential GNSS (DGNSS) is used. For this technique to be effective the maximum distance to a single Reference Station should be no more than 20 km, and when using a network of Reference Stations the distance to the nearest station should no more than about 70 km. This need to set up local Reference Stations limits productivity and increases costs, especially when mapping large areas or long linear features such as roads or pipelines. An alternative technique to DGNSS for high-accuracy positioning from GNSS is the so-called Precise Point Positioning or PPP method. In this case instead of differencing the rover observables with the Reference Station observables to cancel out common errors, an advanced model for every aspect of the GNSS error chain is developed and parameterized to within an accuracy of a few cm. The Trimble Centerpoint RTX positioning solution combines the methodology of PPP with advanced ambiguity resolution technology to produce cm level accuracies without the need for local reference stations. It achieves this through a global deployment of highly redundant monitoring stations that are connected through the internet and are used to determine the precise satellite data with maximum accuracy, robustness, continuity and reliability, along with advance algorithms and receiver and antenna calibrations. This paper presents a new post-processed realization of the Trimble Centerpoint RTX technology integrated into the Applanix POSPac MMS GNSS-Aided Inertial software for mobile mapping. Real-world results from over 100 airborne flights evaluated against a DGNSS network reference are presented which show that the post-processed Centerpoint RTX solution agrees with

  11. Response and Monte Carlo evaluation of a reference ionization chamber for radioprotection level at calibration laboratories

    NASA Astrophysics Data System (ADS)

    Neves, Lucio P.; Vivolo, Vitor; Perini, Ana P.; Caldas, Linda V. E.

    2015-07-01

    A special parallel plate ionization chamber, inserted in a slab phantom for the personal dose equivalent Hp(10) determination, was developed and characterized in this work. This ionization chamber has collecting electrodes and window made of graphite, and the walls and phantom made of PMMA. The tests comprise experimental evaluation following international standards and Monte Carlo simulations, employing the PENELOPE code to evaluate the design of this new dosimeter. The experimental tests were conducted employing the radioprotection level quality N-60 established at the IPEN, and all results were within the recommended standards.

  12. Reference levels of background radioactivity for beach sands and soils in İnebolu/Kastamonu-Turkey

    NASA Astrophysics Data System (ADS)

    Kurnaz, Aslı; Türkdoǧan, Savaş; Hançerlioǧulları, Aybaba; ćetiner, M. Atıf

    2016-03-01

    This paper presents the measurement results of environmental radioactivity levels for İnebolu district (tourist area), Kastamonu-Turkey. The radioactivity concentrations of 238U, 232Th, 40K and the fission product 137Cs in soil samples collected from 13 region surroundings of study area and in 12 beach sand samples collected from along the coast of İnebolu were determined. To evaluate the radiological hazard of the natural radioactivity, based on the measured concentrations of these radionuclides, the mean absorbed gamma dose and the annual effective dose were evaluated separately, and found to be 112.90 nGy h-1 and 138.46 µSv y-1 for soil samples and 75.19 nGy h-1 and 92.22 µSv y-1 for beach sand samples, respectively. The results show that İnebolu does not have high background.

  13. Evaluation of alanine as a reference dosimeter for therapy level dose comparisons in megavoltage electron beams

    NASA Astrophysics Data System (ADS)

    McEwen, Malcolm; Sharpe, Peter; Vörös, Sándor

    2015-04-01

    When comparing absorbed dose standards from different laboratories (e.g. National Measurement Institutes, NMIs, for Key or Supplementary comparisons) it is rarely possible to carry out a direct comparison of primary standard instruments, and therefore some form of transfer detector is required. Historically, air-filled, unsealed ionization chambers have been used because of the long history of using these instruments, very good stability over many years, and ease of transport. However, the use of ion chambers for therapy-level comparisons is not without its problems. Findings from recent investigations suggest that ion chambers are prone to non-random variations, they are not completely robust to standard courier practices, and failure at any step in a comparison can render all measurements potentially useless. An alternative approach is to identify a transfer system that is insensitive to some of these concerns—effectively a dosimeter that is inexpensive, simple to use, robust, but with sufficient precision and of a size relevant to the disseminated quantity in question. The alanine dosimetry system has been successfully used in a number of situations as an audit dosimeter and therefore the purpose of this investigation was to determine whether alanine could also be used as the transfer detector for dosimetric comparisons, which require a lower value for the measurement uncertainty. A measurement protocol was developed for comparing primary standards of absorbed dose to water in high-energy electron beams using alanine pellets irradiated in a water-equivalent plastic phantom. A trial comparison has been carried out between three NMIs and has indicated that alanine is a suitable alternative to ion chambers, with the system used achieving a precision of 0.1%. Although the focus of the evaluation was on the performance of the dosimeter, the comparison results are encouraging, showing agreement at the level of the combined uncertainties (~0.6%). Based on this

  14. Results of a survey on the implementation of diagnostic reference levels for X-rays among Dutch hospitals.

    PubMed

    Bijwaard, Harmen; Valk, Doreth; de Waard-Schalkx, Ischa

    2015-04-01

    Diagnostic reference levels (DRLs) for medical x-ray procedures are being implemented currently in the Netherlands. By order of the Dutch Healthcare Inspectorate, a survey has been conducted among 20 Dutch hospitals to investigate the level of implementation of the Dutch DRLs in current radiological practice. It turns out that hospitals are either well underway in implementing the DRLs or have already done so. However, the DRLs have usually not yet been incorporated in the QA system of the department nor in the treatment protocols. It was shown that the amount of radiation used, as far as it was indicated by the hospitals, usually remains below the DRLs. A procedure for comparing dose levels to the DRLs has been prescribed but is not always followed in practice. This is especially difficult in the case of children, as most general hospitals receive few children.

  15. Reference ranges for urinary levels of testosterone and epitestosterone, which may reveal gonadal function, in a Korean male population.

    PubMed

    Moon, Ju-Yeon; Kwon, Woonyong; Suh, Sungill; Cheong, Jae Chul; In, Moon Kyo; Chung, Bong Chul; Kim, Jin Young; Choi, Man Ho

    2014-03-01

    Cannabis, or marijuana, the most commonly used illicit drug in the world, has been shown to be responsible for suppressing the production and secretion of androgens, particularly testosterone. However, despite such findings in animals, the chronic effects of marijuana use on human endocrine systems have proved to be inconsistent. Here, we investigated the reference ranges of urinary levels of testosterone (T) and epitestosterone (E) as well as their metabolic ratio of T/E in a Korean male population (n=337), which would enable an evaluation of abnormal changes in steroid metabolism induced by habitually administered cannabis. The T/E ratio was significantly decreased in the marijuana group (n=18), while the urinary testosterone concentrations were also tended to decrease. This study is the first to provide data for the reference values of two urinary androgens and T/E values among control Korean males, and, furthermore, suggests that the T/E ratio, though not testosterone levels, might be used to understand the suppression of human male gonadal function affected by smoking marijuana. PMID:24333796

  16. Determination of the relative level of detection of a Qualitative microbiological measurement method with respect to a reference measurement method.

    PubMed

    Mărgăritescu, Irina; Wilrich, Peter-Th

    2013-01-01

    Performance of qualitative microbiological measurement methods where the results are either "O" (microorganism not detected) or "1" (microorganism detected) is described by their probability of detection (POD) function, i.e., the POD as a function of the level of contamination of the sample, expressed as CFU/g or CFU/mL, or by the level of detection (LODp), i.e., the contamination of the sample that is detected (measurement result "1") with a specified probability p. When it is impossible to obtain samples of known contamination, estimation of the POD and LOD is impossible. However, it may not be the LOD of the method that is of interest, but its LOD with respect to the LOD of a reference method. Hence, an intralaboratory experiment is performed with a reference method, R, and an alternative method, A, at different levels of unknown contamination. A complementary loglog model is used to statistically estimate the relative LOD (RLOD) of A with respect to R that is equal for all chosen values p of the POD. An intralaboratory experiment for the detection of Listeria monocytogenes in fish and eggs illustrates the method. In a simulation study, the bias of the estimate of the RLOD was investigated. This bias is due to the small number of repeated measurements in intralaboratory studies; the relative bias increases with increasing true values of the RLOD from 0 for true RLOD = 1 to about 20% for true RLOD = 3. If the number of CFUs in the test portions does not follow a Poisson distribution, but instead follows a negative binomial distribution, e.g., because of overdispersion, the bias of the estimate of the RLOD decreases. An EXCEL program RLOD_ver1. xlsm for this method of statistical analysis can be downloaded from http://www.wiwiss.fu-berlin.de/ instituteliso/mitarbeiterlwilrichlindex.html.

  17. Perturbational treatment of spin-orbit coupling for generally applicable high-level multi-reference methods

    SciTech Connect

    Mai, Sebastian; Marquetand, Philipp; González, Leticia; Müller, Thomas; Plasser, Felix; Lischka, Hans

    2014-08-21

    An efficient perturbational treatment of spin-orbit coupling within the framework of high-level multi-reference techniques has been implemented in the most recent version of the COLUMBUS quantum chemistry package, extending the existing fully variational two-component (2c) multi-reference configuration interaction singles and doubles (MRCISD) method. The proposed scheme follows related implementations of quasi-degenerate perturbation theory (QDPT) model space techniques. Our model space is built either from uncontracted, large-scale scalar relativistic MRCISD wavefunctions or based on the scalar-relativistic solutions of the linear-response-theory-based multi-configurational averaged quadratic coupled cluster method (LRT-MRAQCC). The latter approach allows for a consistent, approximatively size-consistent and size-extensive treatment of spin-orbit coupling. The approach is described in detail and compared to a number of related techniques. The inherent accuracy of the QDPT approach is validated by comparing cuts of the potential energy surfaces of acrolein and its S, Se, and Te analoga with the corresponding data obtained from matching fully variational spin-orbit MRCISD calculations. The conceptual availability of approximate analytic gradients with respect to geometrical displacements is an attractive feature of the 2c-QDPT-MRCISD and 2c-QDPT-LRT-MRAQCC methods for structure optimization and ab inito molecular dynamics simulations.

  18. Perturbational treatment of spin-orbit coupling for generally applicable high-level multi-reference methods

    NASA Astrophysics Data System (ADS)

    Mai, Sebastian; Müller, Thomas; Plasser, Felix; Marquetand, Philipp; Lischka, Hans; González, Leticia

    2014-08-01

    An efficient perturbational treatment of spin-orbit coupling within the framework of high-level multi-reference techniques has been implemented in the most recent version of the Columbus quantum chemistry package, extending the existing fully variational two-component (2c) multi-reference configuration interaction singles and doubles (MRCISD) method. The proposed scheme follows related implementations of quasi-degenerate perturbation theory (QDPT) model space techniques. Our model space is built either from uncontracted, large-scale scalar relativistic MRCISD wavefunctions or based on the scalar-relativistic solutions of the linear-response-theory-based multi-configurational averaged quadratic coupled cluster method (LRT-MRAQCC). The latter approach allows for a consistent, approximatively size-consistent and size-extensive treatment of spin-orbit coupling. The approach is described in detail and compared to a number of related techniques. The inherent accuracy of the QDPT approach is validated by comparing cuts of the potential energy surfaces of acrolein and its S, Se, and Te analoga with the corresponding data obtained from matching fully variational spin-orbit MRCISD calculations. The conceptual availability of approximate analytic gradients with respect to geometrical displacements is an attractive feature of the 2c-QDPT-MRCISD and 2c-QDPT-LRT-MRAQCC methods for structure optimization and ab inito molecular dynamics simulations.

  19. Development of Diagnostic Reference Levels Using a Real-Time Radiation Dose Monitoring System at a Cardiovascular Center in Korea.

    PubMed

    Kim, Jungsu; Seo, Deoknam; Choi, Inseok; Nam, Sora; Yoon, Yongsu; Kim, Hyunji; Her, Jae; Han, Seonggyu; Kwon, Soonmu; Park, Hunsik; Yang, Dongheon; Kim, Jungmin

    2015-12-01

    Digital cardiovascular angiography accounts for a major portion of the radiation dose among the examinations performed at cardiovascular centres. However, dose-related information is neither monitored nor recorded systemically. This report concerns the construction of a radiation dose monitoring system based on digital imaging and communications in medicine (DICOM) data and its use at the cardiovascular centre of the University Hospitals in Korea. The dose information was analysed according to DICOM standards for a series of procedures, and the formulation of diagnostic reference levels (DRLs) at our cardiovascular centre represents the first of its kind in Korea. We determined a dose area product (DAP) DRL for coronary angiography of 75.6 Gy cm(2) and a fluoroscopic time DRL of 318.0 s. The DAP DRL for percutaneous transluminal coronary intervention was 213.3 Gy cm(2), and the DRL for fluoroscopic time was 1207.5 s.

  20. Development of Diagnostic Reference Levels Using a Real-Time Radiation Dose Monitoring System at a Cardiovascular Center in Korea.

    PubMed

    Kim, Jungsu; Seo, Deoknam; Choi, Inseok; Nam, Sora; Yoon, Yongsu; Kim, Hyunji; Her, Jae; Han, Seonggyu; Kwon, Soonmu; Park, Hunsik; Yang, Dongheon; Kim, Jungmin

    2015-12-01

    Digital cardiovascular angiography accounts for a major portion of the radiation dose among the examinations performed at cardiovascular centres. However, dose-related information is neither monitored nor recorded systemically. This report concerns the construction of a radiation dose monitoring system based on digital imaging and communications in medicine (DICOM) data and its use at the cardiovascular centre of the University Hospitals in Korea. The dose information was analysed according to DICOM standards for a series of procedures, and the formulation of diagnostic reference levels (DRLs) at our cardiovascular centre represents the first of its kind in Korea. We determined a dose area product (DAP) DRL for coronary angiography of 75.6 Gy cm(2) and a fluoroscopic time DRL of 318.0 s. The DAP DRL for percutaneous transluminal coronary intervention was 213.3 Gy cm(2), and the DRL for fluoroscopic time was 1207.5 s. PMID:25700616

  1. Reference levels for corticosterone and immune function in farmed saltwater crocodiles (Crocodylus porosus) hatchlings using current Code of Practice guidelines.

    PubMed

    Finger, John W; Thomson, Peter C; Adams, Amanda L; Benedict, Suresh; Moran, Christopher; Isberg, Sally R

    2015-02-01

    To determine reference levels for on-farm stressors on immune responsiveness and growth rate, 253 hatchling crocodiles from 11 known breeding pairs were repeatedly measured and blood sampled during their first year. Plasma corticosterone (CORT) was used to quantify baseline stress levels in captive animals and were found to be lower (mean 1.83±SE 0.16 ng/mL) than previously reported in saltwater crocodile hatchlings. Two tests of immune function were also conducted. Innate constitutive immunity was assessed using bacterial killing assays (BKA) against two bacterial species: Escherichia coli and Providencia rettgeri, whereby the latter causes considerable economic loss to industry from septicaemic mortalities. Although the bactericidal capabilities were different at approximately 4 months old (32±3% for E. coli and 16±4% for P. rettgeri), the differences had disappeared by approximately 9 months old (58±2% and 68±6%, respectively). To assess immune responsiveness to a novel antigen, the inflammatory swelling response caused by phytohaemagglutinin (PHA) injection was assessed but was only significantly different between Samplings 1 and 3 (5% LSD). There were no significant clutch effects for CORT or PHA but there were for both BKA traits. CORT was not significantly associated with growth (head length) or the immune parameters except for P. rettgeri BKA where higher CORT levels were associated with better bactericidal capability. As such, these results suggest that the crocodiles in this study are not stressed, therefore endorsing the management strategies adopted within the Australian industry Code of Practice.

  2. Carcinogenesis and low-level ionizing radiation with special reference to lung cancer and exposure to radon daughters

    SciTech Connect

    Fabrikant, J.I.

    1982-04-01

    Of the important health effects of ionizing radiation, three important late effects - carcinogenesis, teratogenesis and mutagenesis are of greatest concern. This is because any exposure, even at low levels, carries some risk of such deleterious effects. As the dose of radiation increases above very low levels, the risk of health effects increases. Cancer-induction is the most important late somatic effect of low-dose ionizing radiation. Solid cancers, rather than leukemia, are principal late effects in exposed individuals. Tissues vary greatly in their susceptibility to radiation carcinogenesis. The most frequently occurring radiation-induced cancers in man include, in decreasing order of susceptibility: the female breast, the thyroid gland, the blood-forming tissues, the lung, certain organs of the gastrointestinal tract, and the bones. A number of biological and physical factors affect the cancer risk, such as age, sex, life-style, LET, and RBE. Despite uncertainty about low-level radiation risks, regulatory and advisory bodies must set standards for exposure, and individuals need information to be able to make informed judgments for themselves. From the point of view of the policy maker, the overriding concern is the fact that small doses of radiation can cause people to have more cancers than would otherwise be expected. While concern for all radiation effects exists, our human experience is limited to cancer-induction in exposed populations. This discussion is limited to cancer risk estimation and decision-making in relation to the health effects on populations of exposure to low levels of ionizing radiation. Here, low-level radiation will refer to yearly whole-body doses up to 5 rems or 0.05 Sv, or to cumulative doses up to 50 rems or 0.5 Sv from low-LET radiation and from high-LET radiation. (ERB)

  3. Sensitivity of ecological soil-screening levels for metals to exposure model parameterization and toxicity reference values.

    PubMed

    Sample, Bradley E; Fairbrother, Anne; Kaiser, Ashley; Law, Sheryl; Adams, Bill

    2014-10-01

    Ecological soil-screening levels (Eco-SSLs) were developed by the United States Environmental Protection Agency (USEPA) for the purposes of setting conservative soil screening values that can be used to eliminate the need for further ecological assessment for specific analytes at a given site. Ecological soil-screening levels for wildlife represent a simplified dietary exposure model solved in terms of soil concentrations to produce exposure equal to a no-observed-adverse-effect toxicity reference value (TRV). Sensitivity analyses were performed for 6 avian and mammalian model species, and 16 metals/metalloids for which Eco-SSLs have been developed. The relative influence of model parameters was expressed as the absolute value of the range of variation observed in the resulting soil concentration when exposure is equal to the TRV. Rank analysis of variance was used to identify parameters with greatest influence on model output. For both birds and mammals, soil ingestion displayed the broadest overall range (variability), although TRVs consistently had the greatest influence on calculated soil concentrations; bioavailability in food was consistently the least influential parameter, although an important site-specific variable. Relative importance of parameters differed by trophic group. Soil ingestion ranked 2nd for carnivores and herbivores, but was 4th for invertivores. Different patterns were exhibited, depending on which parameter, trophic group, and analyte combination was considered. The approach for TRV selection was also examined in detail, with Cu as the representative analyte. The underlying assumption that generic body-weight-normalized TRVs can be used to derive protective levels for any species is not supported by the data. Whereas the use of site-, species-, and analyte-specific exposure parameters is recommended to reduce variation in exposure estimates (soil protection level), improvement of TRVs is more problematic.

  4. Sensitivity of ecological soil-screening levels for metals to exposure model parameterization and toxicity reference values

    PubMed Central

    Sample, Bradley E; Fairbrother, Anne; Kaiser, Ashley; Law, Sheryl; Adams, Bill

    2014-01-01

    Ecological soil-screening levels (Eco-SSLs) were developed by the United States Environmental Protection Agency (USEPA) for the purposes of setting conservative soil screening values that can be used to eliminate the need for further ecological assessment for specific analytes at a given site. Ecological soil-screening levels for wildlife represent a simplified dietary exposure model solved in terms of soil concentrations to produce exposure equal to a no-observed-adverse-effect toxicity reference value (TRV). Sensitivity analyses were performed for 6 avian and mammalian model species, and 16 metals/metalloids for which Eco-SSLs have been developed. The relative influence of model parameters was expressed as the absolute value of the range of variation observed in the resulting soil concentration when exposure is equal to the TRV. Rank analysis of variance was used to identify parameters with greatest influence on model output. For both birds and mammals, soil ingestion displayed the broadest overall range (variability), although TRVs consistently had the greatest influence on calculated soil concentrations; bioavailability in food was consistently the least influential parameter, although an important site-specific variable. Relative importance of parameters differed by trophic group. Soil ingestion ranked 2nd for carnivores and herbivores, but was 4th for invertivores. Different patterns were exhibited, depending on which parameter, trophic group, and analyte combination was considered. The approach for TRV selection was also examined in detail, with Cu as the representative analyte. The underlying assumption that generic body-weight–normalized TRVs can be used to derive protective levels for any species is not supported by the data. Whereas the use of site-, species-, and analyte-specific exposure parameters is recommended to reduce variation in exposure estimates (soil protection level), improvement of TRVs is more problematic. Environ Toxicol Chem 2014

  5. Technology, Safety and Costs of Decommissioning a Reference Low-Level Waste Burial Ground Environmental Surveillance Programs

    SciTech Connect

    Denham, D. H.; Eddy, P. A.; Hawley, K. A.; Jaquish, R. E.; Corley, J. P.

    1981-07-01

    This Addendum supplements, and to some extent replaces, the preliminary description of environmental radiological surveillance programs for low-level waste burial grounds (LLWBG) used in the parent document, 11 Technology, Safety and Costs of DecolliTlissioning a Reference Low-Level Waste Burial Ground, 11 NUREG/ CR-0570. The Addendum provides additional detail and rationale for the environmental radiological surveillance programs for the two referenced sites and inventories described in NUREG/CR-0570. The rationale and performance criteria herein are expected to be useful in providing guidance for determining the acceptability of environmental surveillance programs for other inventories and other LLWBG sites. Two generic burial grounds, one located on an arid western site and the other located on a humid eastern site, are reference facilities considered in this Addendum, and as described in the parent document (NUREG/CR-0570). The two sites are assumed to have the same capacity for waste, the same radioactive waste inventory, and similar trench characteristics and operating procedures. The climate, geology, and hydrology of the two reference sites are typical of existing western and eastern sites, altnough a single population distribution was chosen for both. Each reference burial ground occupies about 70 hectares and includes 180 trenches filled with a total of 1.5 x 10{sup 6} m{sup 3} of radioactive waste. In acldition, there are 10 slit trenches containing about 1.5 x 10{sup 3} m{sup 3} of high beta-gamma activity waste. In this Addendum environmental surveillance programs are described for the several periods in the life of a LLWBG: preoperational (prior to nuclear waste receipt); operational (including interim trench closures); post-operational (after all nuclear waste is received), for both short-term {up to three years) and long-term (up to 100 years) storage and custodial care; and decommissioning (only for the special case of waste removal). The specific

  6. On the determination of reference levels for quality assurance of flattening filter free photon beams in radiation therapy

    SciTech Connect

    Clivio, Alessandro; Belosi, Maria Francesca; Cozzi, Luca; Nicolini, Giorgia; Vanetti, Eugenio; Fogliata, Antonella; Bolard, Grégory; Fenoglietto, Pascal; Krauss, Harald

    2014-02-15

    Purpose: New definitions for some dosimetric parameters for use in quality assurance of flattening filter free (FFF) beams generated by medical linear accelerators have been suggested. The present study aims to validate these suggestions and to propose possible reference levels. Methods: The main characteristics of FFF photon beams were described in terms of: field size, penumbra, unflatness, slope, and peak-position parameters. Data were collected for 6 and 10 MV-FFF beams from three different Varian TrueBeam Linacs. Measurements were performed with a 2D-array (Starcheck system from PTW-Freiburg) and with the portal dosimetry method GLAaS utilizing the build-in portal imager of TrueBeam. Data were also compared to ion chamber measurements. A cross check validation has been performed on a FFF beam of 6 MV generated by a Varian Clinac-iX upgraded to FFF capability. Results : All the parameters suggested to characterize the FFF beams resulted easily measurable and little variation was observed among different Linacs. Referring to two reference field sizes of 10 × 10 and 20 × 20 cm{sup 2}, at SDD = 100 cm and d = dmax, from the portal dosimetry data, the following results (averaging X and Y profiles) were obtained. Field size: 9.95 ± 0.02 and 19.98 ± 0.03 cm for 6 MV-FFF (9.94 ± 0.02 and 19.98 ± 0.03 cm for 10 MV-FFF). Penumbra: 2.7 ± 0.3 and 2.9 ± 0.3 mm for 6 MV-FFF (3.1 ± 0.2 and 3.3 ± 0.3 for 10 MV-FFF). Unflatness: 1.11 ± 0.01 and 1.25 ± 0.01 for 6 MV-FFF (1.21 ± 0.01 and 1.50 ± 0.01 for 10 MV-FFF). Slope: 0.320 ± 0.020%/mm and 0.43 ± 0.015%/mm for 6 MV-FFF (0.657 ± 0.023%/mm and 0.795 ± 0.017%/mm for 10 MV-FFF). Peak Position −0.2 ± 0.2 and −0.4 ± 0.2 mm for 6 MV-FFF (−0.3 ± 0.2 and 0.7 ± 0.3 mm for 10 MV-FFF). Results would depend upon measurement depth. With thresholds set to at least 95% confidence level from the measured data and to account for possible variations between detectors and methods and experimental settings, a

  7. Reference levels in the context of Fukushima - lessons learned and a challenge for the radiation protection system.

    PubMed

    Sakai, K

    2012-01-01

    A number of dose criteria were set after the accident in Fukushima, including a criterion regarding the use of school playgrounds in Fukushima. Considering the band of 1-20 mSv/year recommended by the International Commission on Radiological Protection (ICRP) for public exposure under existing exposure situations, Japanese authorities set 20 mSv/year as a 'start line' for reducing the dose to school children. However, this led to considerable confusion among the general public and some experts. They thought that the dose limit was increased to 20 mSv/year (20 times as high as before), and that school children could be exposed to 20 mSv in 1 year. This is just an example of confusion caused by inadequate comprehension of radiation effects, misunderstanding of radiation protection concepts, or both. Another issue was raised regarding the higher radiosensitivity of children compared with adults. In the 2007 ICRP Recommendations, a higher risk coefficient is given to the whole population than the adult population, because the whole population includes children; a subpopulation with higher radiosensitivity and a longer life span. The point of argument was whether a lower reference level should be set for children alone. Radiation protection experts should continue to collect scientific information to improve the radiation protection system. In addition, it is the role of these experts to explain the framework of radiation protection to the general public in plain language. PMID:23089027

  8. Relationships Between Spiritual Quotient and Marital Satisfaction Level of Men, Women and Couples Referred to Consultancy Centers of Bandar Abbas

    PubMed Central

    Zarei, Eghbal; Ahmadisarkhooni, Tahereh

    2013-01-01

    Objective: The aim of this research is to determine the relationship between Spiritual Quotient parameters including understanding, life origin, and spiritual life and marital satisfaction of couples in Bandar Abbas City. Methods: It is descriptive correlational study. 150 couples referred to consultancy centers of Bandar Abbas City were selected by accessible sampling method. We utilized Spiritual Quotient Questionnaire and Marriage Satisfaction Questionnaire (ENRICH) which both have high reliability and validity levels. We calculated men, women and couples’ scores in the questionnaires. Results: According to the findings; among all parameters of Spiritual Quotient, spiritual life had the strongest correlation with spiritual quotient (r=0.282 and r=0.277 for men and women; P<0.01 for both). Meanwhile, there were not any significant relationship between couples’ understanding and origin of life and their marital satisfaction. Conclusion: Overall, we can conclude that training according to cultural conditions as well as promoting couples’ spiritual quotient can be utilized to improve the quality of marital life of couples.–More studies should be conducted for further evaluation of the relationship between SQ and marital satisfaction. The results can be used for helping couples in increasing their marital satisfaction. Declaration of interest: None PMID:24644499

  9. Reference levels in the context of Fukushima - lessons learned and a challenge for the radiation protection system.

    PubMed

    Sakai, K

    2012-01-01

    A number of dose criteria were set after the accident in Fukushima, including a criterion regarding the use of school playgrounds in Fukushima. Considering the band of 1-20 mSv/year recommended by the International Commission on Radiological Protection (ICRP) for public exposure under existing exposure situations, Japanese authorities set 20 mSv/year as a 'start line' for reducing the dose to school children. However, this led to considerable confusion among the general public and some experts. They thought that the dose limit was increased to 20 mSv/year (20 times as high as before), and that school children could be exposed to 20 mSv in 1 year. This is just an example of confusion caused by inadequate comprehension of radiation effects, misunderstanding of radiation protection concepts, or both. Another issue was raised regarding the higher radiosensitivity of children compared with adults. In the 2007 ICRP Recommendations, a higher risk coefficient is given to the whole population than the adult population, because the whole population includes children; a subpopulation with higher radiosensitivity and a longer life span. The point of argument was whether a lower reference level should be set for children alone. Radiation protection experts should continue to collect scientific information to improve the radiation protection system. In addition, it is the role of these experts to explain the framework of radiation protection to the general public in plain language.

  10. Survey of computed tomography doses and establishment of national diagnostic reference levels in the Republic of Belarus.

    PubMed

    Kharuzhyk, S A; Matskevich, S A; Filjustin, A E; Bogushevich, E V; Ugolkova, S A

    2010-01-01

    Computed tomography dose index (CTDI) was measured on eight CT scanners at seven public hospitals in the Republic of Belarus. The effective dose was calculated using normalised values of effective dose per dose-length product (DLP) over various body regions. Considerable variations of the dose values were observed. Mean effective doses amounted to 1.4 +/- 0.4 mSv for brain, 2.6 +/- 1.0 mSv for neck, 6.9 +/- 2.2 mSv for thorax, 7.0 +/- 2.3 mSv for abdomen and 8.8 +/- 3.2 mSv for pelvis. Diagnostic reference levels (DRLs) were proposed by calculating the third quartiles of dose value distributions (body region/volume CTDI, mGy/DLP, mGy cm): brain/60/730, neck/55/640, thorax/20/500, abdomen/25/600 and pelvis/25/490. It is evident that the protocols need to be optimised on some of the CT scanners, in view of the fact that these are the first formulated DRLs for the Republic of Belarus.

  11. Evidence of dose saving in routine CT practice using iterative reconstruction derived from a national diagnostic reference level survey

    PubMed Central

    Hayton, A; Beveridge, T; Marks, P; Wallace, A

    2015-01-01

    Objective: To assess the influence and significance of the use of iterative reconstruction (IR) algorithms on patient dose in CT in Australia. Methods: We examined survey data submitted to the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) National Diagnostic Reference Level Service (NDRLS) during 2013 and 2014. We compared median survey dose metrics with categorization by scan region and use of IR. Results: The use of IR results in a reduction in volume CT dose index of between 17% and 44% and a reduction in dose–length product of between 14% and 34% depending on the specific scan region. The reduction was highly significant (p < 0.001, Wilcoxon rank-sum test) for all six scan regions included in the NDRLS. Overall, 69% (806/1167) of surveys included in the analysis used IR. Conclusion: The use of IR in CT is achieving dose savings of 20–30% in routine practice in Australia. IR appears to be widely used by participants in the ARPANSA NDRLS with approximately 70% of surveys submitted employing this technique. Advances in knowledge: This study examines the impact of the use of IR on patient dose in CT on a national scale. PMID:26133224

  12. Local patient dose diagnostic reference levels in pediatric interventional cardiology in Chile using age bands and patient weight values

    SciTech Connect

    Ubeda, Carlos; Miranda, Patricia; Vano, Eliseo

    2015-02-15

    Purpose: To present the results of a patient dose evaluation program in pediatric cardiology and propose local diagnostic reference levels (DRLs) for different types of procedure and age range, in addition to suggesting approaches to correlate patient dose values with patient weight. This study was the first conducted in Latin America for pediatric interventional cardiology under the auspices of the International Atomic Energy Agency. Methods: Over three years, the following data regarding demographic and patient dose values were collected: age, gender, weight, height, number of cine series, total number of cine frames, fluoroscopy time (FT), and two dosimetric quantities, dose-area product (DAP) and cumulative dose (CD), at the patient entrance reference point. The third quartile values for FT, DAP, CD, number of cine series, and the DAP/body weight ratio were proposed as the set of quantities to use as local DRLs. Results: Five hundred and seventeen patients were divided into four age groups. Sample sizes by age group were 120 for <1 yr; 213 for 1 to <5 yr; 82 for 5 to <10 yr; and 102 for 10 to <16 yr. The third quartile values obtained for DAP by diagnostic and therapeutic procedures and age range were 1.17 and 1.11 Gy cm{sup 2} for <1 yr; 1.74 and 1.90 Gy cm{sup 2} for 1 to <5 yr; 2.83 and 3.22 Gy cm{sup 2} for 5 to <10 yr; and 7.34 and 8.68 Gy cm{sup 2} for 10 to <16 yr, respectively. The third quartile value obtained for the DAP/body weight ratio for the full sample of procedures was 0.17 (Gy cm{sup 2}/kg) for diagnostic and therapeutic procedures. Conclusions: The data presented in this paper are an initial attempt at establishing local DRLs in pediatric interventional cardiology, from a large sample of procedures for the standard age bands used in Europe, complemented with the values of the ratio between DAP and patient weight. This permits a rough estimate of DRLs for different patient weights and the refining of these values for the age bands when there

  13. Characteristics of the Remote Sensing Data Used in the Proposed Unfccc REDD+ Forest Reference Emission Levels (frels)

    NASA Astrophysics Data System (ADS)

    Johnson, B. A.; Scheyvens, H.; Samejima, H.; Onoda, M.

    2016-06-01

    Developing countries must submit forest reference emission levels (FRELs) to the UNFCCC to receive incentives for REDD+ activities (e.g. reducing emissions from deforestation/forest degradation, sustainable management of forests, forest carbon stock conservation/enhancement). These FRELs are generated based on historical CO2 emissions in the land use, land use change, and forestry sector, and are derived using remote sensing (RS) data and in-situ forest carbon measurements. Since the quality of the historical emissions estimates is affected by the quality and quantity of the RS data used, in this study we calculated five metrics (i-v below) to assess the quality and quantity of the data that has been used thus far. Countries could focus on improving on one or more of these metrics for the submission of future FRELs. Some of our main findings were: (i) the median percentage of each country mapped was 100%, (ii) the median historical timeframe for which RS data was used was 11.5 years, (iii) the median interval of forest map updates was 4.5 years, (iv) the median spatial resolution of the RS data was 30m, and (v) the median number of REDD+ activities that RS data was used for operational monitoring of was 1 (typically deforestation). Many new sources of RS data have become available in recent years, so complementary or alternative RS data sets for generating future FRELs can potentially be identified based on our findings; e.g. alternative RS data sets could be considered if they have similar or higher quality/quantity than the currently-used data sets.

  14. Development of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling.

    PubMed

    Thompson, Chad M; Gaylor, David W; Tachovsky, J Andrew; Perry, Camarie; Carakostas, Michael C; Haws, Laurie C

    2013-12-01

    Sulfolane is a widely used industrial solvent that is often used for gas treatment (sour gas sweetening; hydrogen sulfide removal from shale and coal processes, etc.), and in the manufacture of polymers and electronics, and may be found in pharmaceuticals as a residual solvent used in the manufacturing processes. Sulfolane is considered a high production volume chemical with worldwide production around 18 000-36 000 tons per year. Given that sulfolane has been detected as a contaminant in groundwater, an important potential route of exposure is tap water ingestion. Because there are currently no federal drinking water standards for sulfolane in the USA, we developed a noncancer oral reference dose (RfD) based on benchmark dose modeling, as well as a tap water screening value that is protective of ingestion. Review of the available literature suggests that sulfolane is not likely to be mutagenic, clastogenic or carcinogenic, or pose reproductive or developmental health risks except perhaps at very high exposure concentrations. RfD values derived using benchmark dose modeling were 0.01-0.04 mg kg(-1) per day, although modeling of developmental endpoints resulted in higher values, approximately 0.4 mg kg(-1) per day. The lowest, most conservative, RfD of 0.01 mg kg(-1) per day was based on reduced white blood cell counts in female rats. This RfD was used to develop a tap water screening level that is protective of ingestion, viz. 365 µg l(-1). It is anticipated that these values, along with the hazard identification and dose-response modeling described herein, should be informative for risk assessors and regulators interested in setting health-protective drinking water guideline values for sulfolane.

  15. Fabrication and qualification of roughness reference samples for industrial testing of surface roughness levels below 0.5 nm Sq

    NASA Astrophysics Data System (ADS)

    Faehnle, O.; Langenbach, E.; Zygalsky, F.; Frost, F.; Fechner, R.; Schindler, A.; Cumme, M.; Biskup, H.; Wünsche, C.; Rascher, R.

    2015-08-01

    Applying reactive ion beam etching (RIBE) processes at the Leibniz Institute of Surface Modification (IOM), several reference samples to be used in industry for calibrating of roughness testing equipment have been generated with the smoothest sample featuring 0.1 nm rms Sq. Subsequently these reference samples have been measured cross-site applying atomic force microscopy (AFM), white light interferometry (WLI), Nomarski1 microscopy (NM) and scatterometry (iTIRM2) determining the appropriate range of measurable rms surface roughness for each industrial measuring device.

  16. Age- and Gender-Specific Reference Intervals for Fasting Blood Glucose and Lipid Levels in School Children Measured With Abbott Architect c8000 Chemistry Analyzer.

    PubMed

    Tamimi, Waleed; Albanyan, Esam; Altwaijri, Yasmin; Tamim, Hani; Alhussein, Fahad

    2012-04-01

    Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6-7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations.

  17. Troubled or Troubling? Characteristics of Youth Referred to a System of Care without System-Level Referral Constraints.

    ERIC Educational Resources Information Center

    Rosenblatt, Jennifer; Robertson, Laurel; Bates, Michael; Wood, Michelle; Furlong, Michael J.; Sosna, Todd

    1998-01-01

    The characteristics of 128 youth with emotional and behavioral disorders referred to a multiagency care system were investigated according to agency referral, behavioral/emotional issues, and risk factors. Four types of referral profiles were identified: troubled, troubling, troubled and troubling, and at risk. Results are related to the policy…

  18. An Analysis of HIV and AIDS Spatial Awareness and Vulnerability Level with Specific Reference to Staff at One Polytechnic in Zimbabwe

    ERIC Educational Resources Information Center

    Gatsi, Caroline; Chikuvadze, Pinias; Mugijima, Samuel

    2016-01-01

    With the gravity of the HIV and AIDS situation in most African nations and its implications for the education sector, a study was undertaken to analyze the spatial awareness and vulnerability level to pandemic in tertiary institutions with specific reference to academic and support staff at one polytechnic in Zimbabwe. A sample comprised of…

  19. Reference values of cadmium, arsenic and manganese in blood and factors associated with exposure levels among adult population of Rio Branco, Acre, Brazil.

    PubMed

    Freire, Carmen; Koifman, Rosalina Jorge; Fujimoto, Denys; de Oliveira Souza, Vanessa Cristina; Barbosa, Fernando; Koifman, Sergio

    2015-06-01

    This study aimed to investigate the distribution and factors influencing blood levels of Cadmium (Cd), Arsenic (As), and Manganese (Mn), and to determine their reference values in a sample of blood donors residing in Rio Branco, capital city of Acre State, Brazil. Blood samples were collected from all blood donors attending the Central Hemotherapic Unit in Rio Branco between 2010 and 2011. Among these, 1183 donors (98.9%) answered to a questionnaire on sociodemographic and lifestyle factors. Blood metal concentrations were determined by atomic spectrometry. Association between Cd, As and Mn levels and donors' characteristics was examined by linear regression analysis. Reference values were estimated as the upper limit of the 95% confidence interval of the 95th percentile of metal levels. References values were 0.87 μg L(-1) for Cd, 9.87 μg L(-1) for As, and 29.32 μg L(-1) for Mn. Reference values of Cd and As in smokers were 2.66 and 10.86 μg L(-1), respectively. Factors contributing to increase Cd levels were smoking, ethnicity (non-white), and lower education, whereas drinking tea and non-bottled water were associated with lower Cd. Lower levels of As were associated with higher household income, living near industrial facilities, working in a glass factory, a compost plant or in metal mining activities. Risk factors for Mn exposure were not identified. In general, blood Cd concentrations were in the range of exposure levels reported for other people from the general population, whereas levels of As and Mn were higher than in other non-occupationally exposed populations elsewhere.

  20. Assessing the Potential for Salmon Recovery via Floodplain Restoration: A Multitrophic Level Comparison of Dredge-Mined to Reference Segments

    NASA Astrophysics Data System (ADS)

    Bellmore, J. Ryan; Baxter, Colden V.; Ray, Andrew M.; Denny, Lytle; Tardy, Kurt; Galloway, Evelyn

    2012-03-01

    Pre-restoration studies typically focus on physical habitat, rather than the food-base that supports aquatic species. However, both food and habitat are necessary to support the species that habitat restoration is frequently aimed at recovering. Here we evaluate if and how the productivity of the food-base that supports fish production is impaired in a dredge-mined floodplain within the Yankee Fork Salmon River (YFSR), Idaho (USA); a site where past restoration has occurred and where more has been proposed to help recover anadromous salmonids. Utilizing an ecosystem approach, we found that the dredged segment had comparable terrestrial leaf and invertebrate inputs, aquatic primary producer biomass, and production of aquatic invertebrates relative to five reference floodplains. Thus, the food-base in the dredged segment did not necessarily appear impaired. On the other hand, we observed that off-channel aquatic habitats were frequently important to productivity in reference floodplains, and the connection of these habitats in the dredged segment via previous restoration increased invertebrate productivity by 58%. However, using a simple bioenergetic model, we estimated that the invertebrate food-base was at least 4× larger than present demand for food by fish in dredged and reference segments. In the context of salmon recovery efforts, this observation questions whether additional food-base productivity provided by further habitat restoration would be warranted in the YFSR. Together, our findings highlight the importance of studies that assess the aquatic food-base, and emphasize the need for more robust ecosystem models that evaluate factors potentially limiting fish populations that are the target of restoration.

  1. Normal reference ranges for and variability in the levels of blood manganese and selenium by gender, age, and race/ethnicity for general U.S. population.

    PubMed

    Jain, Ram B; Choi, Y Sammy

    2015-04-01

    Data from National Health and Nutrition Examination Survey for the period 2011-2012 were used to determine normal reference ranges and percentile distributions for manganese (Mn) and selenium (Se) in blood by gender, age, race/ethnicity, socioeconomic status as determined by annual family income, and smoking status. The effect of gender, age, race/ethnicity, family income, and smoking status on the levels of Mn and Se was also determined by fitting regression models. Males had lower adjusted levels of Mn and higher adjusted levels of Se than females. Adjusted levels of Mn decreased with increase in age but adjusted levels of Se were lower in adolescents aged 12-19 years than adults aged 20-64 years. Non-Hispanic black (NHB) had the lowest levels of both Mn and Se and non-Hispanic Asians (NHAS) had the highest levels of both Mn and Se. Non-Hispanic white (NHW) and NHB had lower levels of Mn than Hispanics (HISP) and NHAS. NHB and HISP had lower levels of Se than NHW and NHAS. Low annual income (<$20,000) was associated with lower levels of Se than high annual income (≥$55,000). Smoking negatively affected the adjusted levels of Se among seniors aged ≥65 years but this was not observed in other age groups. Mn levels were not affected by smoking.

  2. Causes of creatine kinase levels greater than 1000 IU/L in patients referred to rheumatology.

    PubMed

    Leverenz, David; Zaha, Oana; Crofford, Leslie J; Chung, Cecilia P

    2016-06-01

    Patients with severely elevated creatine kinase (CK) concentrations are commonly referred to rheumatologists to evaluate for the presence of an idiopathic inflammatory myopathy (IIM). However, no studies have evaluated the frequency with which IIMs are encountered in this clinical scenario. The Vanderbilt Synthetic Derivative, a de-identified copy of over 2 million patient records, was searched to identify adult patients with a CK greater than 1000 IU/L who had been evaluated by a rheumatologist. Each patient was assigned a diagnosis using a pre-determined algorithm. The records were then reviewed for pertinent demographic data and clinical characteristics. A total of 192 patients were included for analysis. Of these patients, 105 (55 %) were diagnosed with an IIM. The non-IIM causes were drug/toxin exposure (n = 16, 8 %), infection (n = 12, 6 %), trauma (n = 10, 5 %), myocardial injury (n = 5, 3 %), hypothyroidism (n = 4, 2 %), muscular dystrophy (n = 4, 2 %), neuropsychiatric disorder (n = 3, 2 %), metabolic myopathy (n = 2, 1 %), idiopathic CK elevation (n = 11, 6 %), and other diagnoses (n = 20, 10 %). Several characteristics were found to be significantly different between IIM and non-IIM cases. In particular, patients with an IIM were more likely to be female, have a positive ANA, have interstitial lung disease, and have proximal, symmetric weakness. This study found that approximately half of patients referred to our division of rheumatology with a CK greater than 1000 IU/L were diagnosed with an IIM. Given the importance of prompt diagnosis and treatment of these disorders, rapid assessment by the consulting rheumatologist for these patients is recommended. PMID:27041384

  3. Problems of rising ground-water levels in urban areas with special reference to the Louisville, Kentucky area

    USGS Publications Warehouse

    Whitesides, D.V.; Faust, R.J.; Zettwoch, D.D.

    1983-01-01

    Rising ground-water levels are a problem for cities such as San Bernadino, California; Greely and Fort Collins, Colorado; New York City boroughs of Brooklyn and Queens; and Louisville, Kentucky. Ground-water levels showed a steeply rising trend in the alluvial aquifer underlying Louisville during the early and middle 1970 's in response to above average precipitation and a decrease in ground-water withdrawals. This rising trend flattened in 1979 and the water levels are stabilizing at 25 to 45 feet below land surface in the downtown area. Basements are generally 20 to 25 feet below land surface and some utility lines are as much as 40 feet below land surface in this area. Because of the shallow depth to water, any resumption of the upward trend would require preventive measures such as selective dewatering to avoid damage to some structures. (USGS)

  4. SUMMER AND WINTER VITAMIN D3 LEVELS IN FOUR LEMUR SPECIES HOUSED AT A BRITISH ZOO, WITH REFERENCE TO UVB LEVELS.

    PubMed

    Killick, Rowena; Saunders, Richard; Redrobe, Sharon P

    2015-09-01

    Serum samples were collected from 18 lemurs of four diurnal/cathemeral species housed with outdoor access at Bristol Zoo Gardens (United Kingdom) to test 25-hydroxy-vitamin D3 (25OHD3) levels as part of the veterinary department's preventative health care program. Samples were collected from each lemur in August 2008 (summer) and January 2009 (winter) to examine the effect of season on 25OHD3 levels. The lemurs were fed commercial primate food and a range of fruit and vegetables, and dietary levels of vitamin D3 remained the same throughout the study period. Statistical analysis showed that the lemurs' summer 25OHD3 values (range 26.7 to >150.0 μg/L) were significantly higher than their winter 25OHD3 values (range 11.4-87.1 μg/L). UVB measurements taken during the study period confirmed that UVB levels were significantly higher in summer (mean reading for 1200-1300 GMT time period 153.8 μW/cm2) compared to winter (mean reading for 1200-1300 GMT time period 19.4 μW/cm2). The 25OHD3 levels measured were generally found to be high compared to previously published values from wild (free-ranging) lemurs in Madagascar. The most likely explanation for this was the higher vitamin D3 content of the captive lemurs' diet, as UVB levels at the zoo (latitude 51° north) are substantially lower than those that occur in Madagascar (latitude 12°-26° south). No evidence of vitamin D toxicity or deficiency was found in any of the captive lemurs. The results indicate that vitamin D3 levels in lemurs housed with outdoor access in the United Kingdom and by extension, other regions of similar latitude, vary with seasonal environmental UVB levels, in a similar way to the seasonal variations in vitamin D3 observed in humans living in these regions, but that vitamin D levels in this captive lemur population were adequate compared to wild lemur levels, even in winter.

  5. SUMMER AND WINTER VITAMIN D3 LEVELS IN FOUR LEMUR SPECIES HOUSED AT A BRITISH ZOO, WITH REFERENCE TO UVB LEVELS.

    PubMed

    Killick, Rowena; Saunders, Richard; Redrobe, Sharon P

    2015-09-01

    Serum samples were collected from 18 lemurs of four diurnal/cathemeral species housed with outdoor access at Bristol Zoo Gardens (United Kingdom) to test 25-hydroxy-vitamin D3 (25OHD3) levels as part of the veterinary department's preventative health care program. Samples were collected from each lemur in August 2008 (summer) and January 2009 (winter) to examine the effect of season on 25OHD3 levels. The lemurs were fed commercial primate food and a range of fruit and vegetables, and dietary levels of vitamin D3 remained the same throughout the study period. Statistical analysis showed that the lemurs' summer 25OHD3 values (range 26.7 to >150.0 μg/L) were significantly higher than their winter 25OHD3 values (range 11.4-87.1 μg/L). UVB measurements taken during the study period confirmed that UVB levels were significantly higher in summer (mean reading for 1200-1300 GMT time period 153.8 μW/cm2) compared to winter (mean reading for 1200-1300 GMT time period 19.4 μW/cm2). The 25OHD3 levels measured were generally found to be high compared to previously published values from wild (free-ranging) lemurs in Madagascar. The most likely explanation for this was the higher vitamin D3 content of the captive lemurs' diet, as UVB levels at the zoo (latitude 51° north) are substantially lower than those that occur in Madagascar (latitude 12°-26° south). No evidence of vitamin D toxicity or deficiency was found in any of the captive lemurs. The results indicate that vitamin D3 levels in lemurs housed with outdoor access in the United Kingdom and by extension, other regions of similar latitude, vary with seasonal environmental UVB levels, in a similar way to the seasonal variations in vitamin D3 observed in humans living in these regions, but that vitamin D levels in this captive lemur population were adequate compared to wild lemur levels, even in winter. PMID:26352953

  6. Radiostrontium levels in foodstuffs: 4-Years control activity by Italian reference centre, as a contribution to risk assessment.

    PubMed

    Iammarino, Marco; dell'Oro, Daniela; Bortone, Nicola; Mangiacotti, Michele; Damiano, Rita; Chiaravalle, Antonio Eugenio

    2016-11-01

    (90)Sr is considered an important contaminant relating to food supply chains. In this study, 176 liquid and 260 solid foods, were analysed in order to quantify (90)Sr. Through ruggedness tests, the application field of radiochemical methods used was extended successfully to all most important types of foodstuffs. Regarding liquid matrices, milk samples resulted the most important indicator about (90)Sr contamination, with mean (90)Sr activity concentration equal to 0.058BqL(-1). Among other liquid foods, wine/spirits and livestock watering resulted the most contaminated, with mean contamination levels equal to 0.022 and 0.035BqL(-1), respectively. Concerning solid matrices, cheeses produced from sheep's milk and animal feeds resulted the most contaminated (mean levels: 1.237 and 1.557Bqkg(-1), respectively). Meat products and seafood showed contamination levels not significant within this survey; while, among vegetables, cacao/chocolate and spices resulted in contamination levels comparable with those of cheese obtained from milk of cows origin. PMID:27211657

  7. Relevance of biotic pathways to the long-term regulation of nuclear-waste disposal. Topical report on reference western arid low-level sites

    SciTech Connect

    McKenzie, D.H.; Cadwell, L.L.; Eberhardt, L.E.; Kennedy, W.E. Jr.; Peloquin, R.A.; Simmons, M.A.

    1982-10-01

    The purpose of the work reported here was to develop an order of magnitude estimate for the potential dose to man resulting from biotic transport mechanisms at a reference western arid low-level waste site. A description of the reference site is presented that includes the waste inventories, site characteristics and biological communities. Parameter values for biotic transport processes are based on data reported in current literature. Transport and exposure scenarios are developed for assessing biotic transport during 100 years following site closure. Calculations of radionuclide decay and waste container decomposition are made to estimate the quantities available for biotic transport. Dose to a man occupying the reference site following the 100 years of biotic transport are calculated. These dose estimates are compared to dose estimates for the intruder-agricultural scenario reported in the DEIS for 10 CFR 61 (NRC). Dose to man estimates as a result of biotic transport are estimated to be of the same order of magnitude as the dose resulting from the more commonly evaluated human intrusion scenario. The reported lack of potential importance of biotic transport at low-level waste sites in earlier assessment studies is not confirmed by the findings presented in this report. These results indicate that biotic transport has the potential to influence low-level waste site performance. Through biotic transport, radionuclides may be moved to locations where they can enter exposure pathways to man.

  8. GLM Proxy Data Generation: Methods for Stroke/Pulse Level Inter-Comparison of Ground-Based Lightning Reference Networks

    NASA Technical Reports Server (NTRS)

    Cummins, Kenneth L.; Carey, Lawrence D.; Schultz, Christopher J.; Bateman, Monte G.; Cecil, Daniel J.; Rudlosky, Scott D.; Petersen, Walter Arthur; Blakeslee, Richard J.; Goodman, Steven J.

    2011-01-01

    In order to produce useful proxy data for the GOES-R Geostationary Lightning Mapper (GLM) in regions not covered by VLF lightning mapping systems, we intend to employ data produced by ground-based (regional or global) VLF/LF lightning detection networks. Before using these data in GLM Risk Reduction tasks, it is necessary to have a quantitative understanding of the performance of these networks, in terms of CG flash/stroke DE, cloud flash/pulse DE, location accuracy, and CLD/CG classification error. This information is being obtained through inter-comparison with LMAs and well-quantified VLF/LF lightning networks. One of our approaches is to compare "bulk" counting statistics on the spatial scale of convective cells, in order to both quantify relative performance and observe variations in cell-based temporal trends provided by each network. In addition, we are using microsecond-level stroke/pulse time correlation to facilitate detailed inter-comparisons at a more-fundamental level. The current development status of our ground-based inter-comparison and evaluation tools will be presented, and performance metrics will be discussed through a comparison of Vaisala s Global Lightning Dataset (GLD360) with the NLDN at locations within and outside the U.S.

  9. Copper and zinc levels in serum and urine of cadmium-exposed people with special reference to renal tubular damage

    SciTech Connect

    Nogawa, K.; Yamada, Y.; Honda, R.; Tsuritani, I.; Kobayashi, E.; Ishizaki, M.

    1984-02-01

    Urinary copper and zinc concentrations and their serum levels were determined in women environmentally exposed to cadmium, including itai-itai disease patients and suspected patients, for evaluating the effect of cadmium exposure on metabolism of such essential metals as copper and zinc in human beings. Copper concentrations in the urine of cadmium-exposed women, especially itai-itai patients and suspected patients, were much higher than those on nonexposed women. Zinc concentrations in the urine of cadmium-exposed women, however, were not different from those of nonexposed women. Zinc levels in the serum of the itai-itai patients were somewhat lower than those of the nonexposed women. On the other hand, serum copper was almost equal in the cadmium-exposed and the nonexposed women. The correlation coefficient between ..beta../sub 2/-microglobulin amounts and copper concentrations in the urine of all women examined was as high as 0.95. It is concluded that exposure to cadmium will cause an increase in the excretion of copper in urine, which is attributable to renal tubular damage due to the cadmium exposure, and that urinary zinc excretion is not increased by cadmium exposure, even in the patients who suffer from severe renal tubular damage.

  10. A review of trend models applied to sea level data with reference to the "acceleration-deceleration debate"

    NASA Astrophysics Data System (ADS)

    Visser, Hans; Dangendorf, Sönke; Petersen, Arthur C.

    2015-06-01

    Global sea levels have been rising through the past century and are projected to rise at an accelerated rate throughout the 21st century. This has motivated a number of authors to search for already existing accelerations in observations, which would be, if present, vital for coastal protection planning purposes. No scientific consensus has been reached yet as to how a possible acceleration could be separated from intrinsic climate variability in sea level records. This has led to an intensive debate on its existence and, if absent, also on the general validity of current future projections. Here we shed light on the controversial discussion from a methodological point of view. To do so, we provide a comprehensive review of trend methods used in the community so far. This resulted in an overview of 30 methods, each having its individual mathematical formulation, flexibilities, and characteristics. We illustrate that varying trend approaches may lead to contradictory acceleration-deceleration inferences. As for statistics-oriented trend methods, we argue that checks on model assumptions and model selection techniques yield a way out. However, since these selection methods all have implicit assumptions, we show that good modeling practices are of importance too. We conclude at this point that (i) several differently characterized methods should be applied and discussed simultaneously, (ii) uncertainties should be taken into account to prevent biased or wrong conclusions, and (iii) removing internally generated climate variability by incorporating atmospheric or oceanographic information helps to uncover externally forced climate change signals.

  11. Relevance of biotic pathways to the long-term regulation of nuclear waste disposal. Topical report on reference eastern humid low-level sites

    SciTech Connect

    McKenzie, D.H.; Cadwell, L.L.; Eberhardt, L.E.; Kennedy, W.E. Jr.; Peloquin, R.A.; Simmons, M.A.

    1983-01-01

    The purpose of the work reported here was to develop an order-of-magnitude estimate for the potential dose to man resulting from biotic transport mechanisms at a humid reference low-level waste site in the eastern US. A description of the reference site is presented that includes the waste inventories, site characteristics and biological communites. Parameter values for biotic transport processes are based on data reported in current literature. Transport and exposure scenarios are developed for assessing biotic transport during 500 years following site closure. Calculations of radionuclide decay and waste container decomposition are made to estimate the quantities available for biotic transport. Doses to man are calculated for the biological transport of radionucludes at the reference site after loss of institutional control. These dose estimates are compared to dose estimates we calculated for the intruder-agricultural scenarios reported in the DEIS for 10 CFR 61 (NRC). Dose to man estimates as a result of cumulative biotic transport are calculated to be of the same order-of-magnitude as the dose resulting from the more commonly evaluated human intrusion scenario. The reported lack of potential importance of biotic transport at low-level waste sites in earlier assessment studies is not confirmed by findings presented in this report. Through biotic transport, radionuclides can be moved to locations where they can enter exposure pathways to man.

  12. Reference design of 100 MW-h lithium/iron sulfide battery system for utility load leveling

    SciTech Connect

    Zivi, S.M.; Kacinskas, H.; Pollack, I.; Chilenskas, A.A.; Barney, D.L.; Grieve, W.; McFarland, B.L.; Sudar, S.; Goldstein, E.; Adler, E.

    1980-03-01

    The first year in a two-year cooperative effort between Argonne National Laboratory and Rockwell International to develop a conceptual design of a lithium alloy/iron sulfide battery for utility load leveling is presented. A conceptual design was developed for a 100 MW-h battery system based upon a parallel-series arrangement of 2.5 kW-h capacity cells. The sales price of such a battery system was estimated to be very high, $80.25/kW-h, exclusive of the cost of the individual cells, the dc-to-ac converters, site preparation, or land acquisition costs. Consequently, the second year's efforts were directed towards developing modified designs with significantly lower potential costs.

  13. Significant RF-EMF and thermal levels observed in a computational model of a person with a tibial plate for grounded 40 MHz exposure.

    PubMed

    McIntosh, Robert L; Iskra, Steve; Anderson, Vitas

    2014-05-01

    Using numerical modeling, a worst-case scenario is considered when a person with a metallic implant is exposed to a radiofrequency (RF) electromagnetic field (EMF). An adult male standing on a conductive ground plane was exposed to a 40 MHz vertically polarized plane wave field, close to whole-body resonance where maximal induced current flows are expected in the legs. A metal plate (50-300 mm long) was attached to the tibia in the left leg. The findings from this study re-emphasize the need to ensure compliance with limb current reference levels for exposures near whole-body resonance, and not just rely on compliance with ambient electric (E) and magnetic (H) field reference levels. Moreover, we emphasize this recommendation for someone with a tibial plate, as failure to comply may result in significant tissue damage (increases in the localized temperature of 5-10 °C were suggested by the modeling for an incident E-field of 61.4 V/m root mean square (rms)). It was determined that the occupational reference level for limb current (100 mA rms), as stipulated in the 1998 guidelines of the International Commission on Non-Ionizing Radiation Protection (ICNIRP), is satisfied if the plane wave incident E-field levels are no more than 29.8 V/m rms without an implant and 23.4 V/m rms for the model with a 300 mm implant.

  14. The Reference Level of Serum S-100B Protein for Poor Prognosis in Patients with Intracranial Extracerebral Hematoma

    PubMed Central

    Kaczmarek, J.; Jankowski, R.; Guzniczak, P.

    2011-01-01

    BACKGROUND S-100B protein, blood-brain barrier permeability marker, is one of a few biochemical indicators useful in the evaluation of traumatic brain injury. Our aim was to correlate serum concentration of S-100B with clinical condition and CT head scan findings as well as to estimate the level of the protein significant for clinical outcome prediction. METHODS The cohort of 41 subjects underwent clinical examination by the neurosurgeon, consciousness was evaluated with Glasgow Coma Scale (GCS). Diagnosis was established on the basis of CT head scans. Venous blood samples were collected before surgery. Serum concentration of S-100B protein was estimated using electrochemiluminesce immunoassays (ECLIA) on Cobas 6000 Analyzer (Roche Diagnostics). Clinical outcome was measured applying Glasgow Outcome Scale (GOS). Finally, data were analyzed with Statistica, v. 8.0 (StatSoft, Inc. 2007). RESULTS The average S-100B concentration was 0.95 ± 1.75 μg/L. Statistical analysis revealed significant correlation between S-100B and GCS, GOS and dimers–D concentration (p<0.001, Spearman correlation test). There were statistically significant differences in the S-100B concentration depending on the presence of brain oedema (1.29±2.02 vs. 0.06±0.03; p<0.01, Mann-Whitney test) or contusion foci (1.37±1.77 vs. 0.72±1.92; p<0.01) in CT scans. The S-100B concentration of 0.288 μg/L was determined as a cut-off point for unfavorable clinical outcome prediction (ROC, p<0.001). CONCLUSIONS Association between serum S-100B concentration and clinical, radiological or laboratory findings prove its usefulness as a diagnostic marker for assessment of brain trauma severity. The concentration of the protein >0.288 μg/L is associated with poor prognosis.

  15. A reference section for the Santonian-Campanian boundary and sea-level fluctuations: The Postalm section, Austria, revisited

    NASA Astrophysics Data System (ADS)

    Wagreich, Michael; Dinarès-Turell, Jaume; Wolfgring, Erik

    2016-04-01

    event. Oxygen isotopes show a negative excursion slightly below the Santonian-Campanian boundary, followed by a trend to more positive values. Together with the magnetic susceptibility data, sequence stratigraphy interpretations and global correlations a sea-level lowstand can be inferred to occur just at the boundary.

  16. An energy decomposition analysis for intermolecular interactions from an absolutely localized molecular orbital reference at the coupled-cluster singles and doubles level

    SciTech Connect

    Azar, R. Julian; Head-Gordon, Martin

    2012-01-14

    We propose a wave function-based method for the decomposition of intermolecular interaction energies into chemically-intuitive components, isolating both mean-field- and explicit correlation-level contributions. We begin by solving the locally-projected self-consistent field for molecular interactions equations for a molecular complex, obtaining an intramolecularly polarized reference of self-consistently optimized, absolutely-localized molecular orbitals (ALMOs), determined with the constraint that each fragment MO be composed only of atomic basis functions belonging to its own fragment. As explicit inter-electronic correlation is integral to an accurate description of weak forces underlying intermolecular interaction potentials, namely, coordinated fluctuations in weakly interacting electronic densities, we add dynamical correlation to the ALMO polarized reference at the coupled-cluster singles and doubles level, accounting for explicit dispersion and charge-transfer effects, which map naturally onto the cluster operator. We demonstrate the stability of energy components with basis set extension, follow the hydrogen bond-breaking coordinate in the C{sub s}-symmetry water dimer, decompose the interaction energies of dispersion-bound rare gas dimers and other van der Waals complexes, and examine charge transfer-dominated donor-acceptor interactions in borane adducts. We compare our results with high-level calculations and experiment when possible.

  17. An energy decomposition analysis for intermolecular interactions from an absolutely localized molecular orbital reference at the coupled-cluster singles and doubles level.

    PubMed

    Azar, R Julian; Head-Gordon, Martin

    2012-01-14

    We propose a wave function-based method for the decomposition of intermolecular interaction energies into chemically-intuitive components, isolating both mean-field- and explicit correlation-level contributions. We begin by solving the locally-projected self-consistent field for molecular interactions equations for a molecular complex, obtaining an intramolecularly polarized reference of self-consistently optimized, absolutely-localized molecular orbitals (ALMOs), determined with the constraint that each fragment MO be composed only of atomic basis functions belonging to its own fragment. As explicit inter-electronic correlation is integral to an accurate description of weak forces underlying intermolecular interaction potentials, namely, coordinated fluctuations in weakly interacting electronic densities, we add dynamical correlation to the ALMO polarized reference at the coupled-cluster singles and doubles level, accounting for explicit dispersion and charge-transfer effects, which map naturally onto the cluster operator. We demonstrate the stability of energy components with basis set extension, follow the hydrogen bond-breaking coordinate in the C(s)-symmetry water dimer, decompose the interaction energies of dispersion-bound rare gas dimers and other van der Waals complexes, and examine charge transfer-dominated donor-acceptor interactions in borane adducts. We compare our results with high-level calculations and experiment when possible.

  18. Reach for Reference. Four Recent Reference Books

    ERIC Educational Resources Information Center

    Safford, Barbara Ripp

    2004-01-01

    This article provides descriptions of four new science and technology encyclopedias that are appropriate for inclusion in upper elementary and/or middle school reference collections. "The Macmillan Encyclopedia of Weather" (Stern, Macmillan Reference/Gale), a one-volume encyclopedia for upper elementary and middle level students, is a…

  19. A comparison of mean glandular dose diagnostic reference levels within the all-digital Irish National Breast Screening Programme and the Irish Symptomatic Breast Services.

    PubMed

    O'Leary, Desiree; Rainford, Louise

    2013-03-01

    Data on image quality, compression and radiation dose were collected from symptomatic breast units within the Republic of Ireland. Quantitative and qualitative data were analysed using SPSS. Recommendations of mean glandular dose (MGD) diagnostic reference levels were made at various levels for film-screen and full field digital mammography units to match levels published worldwide. MGDs received by symptomatic breast patients within Ireland are higher than those received in the all-digital Irish Breast Screening service; 55-65 mm breast: 1.75 mGy (screening) vs. 2.4 mGy (symptomatic) at the 95th percentile; various reasons are proposed for the differences. MGDs achieved in the screening service may be lower because of the exacting requirements for radiographer training, characteristics of the patients and equipment quality assurance levels. More precise imaging guidelines, standards and training of symptomatic radiographers performing mammography are suggested to remediate MGDs delivered to the breasts of Irish women attending the symptomatic breast services. PMID:22740646

  20. Reference levels of the tumor markers carcinoembryonic antigen, the carbohydrate antigens 19-9 and 72-4, and cytokeratin fragment 19 using the Elecsys Relecsys 1010 analyzer in a normal population in Kuwait. The importance of the determination of local reference levels.

    PubMed

    Behbehani, A I; Mathew, A; Farghaly, M; van Dalen, A

    2002-01-01

    The tumor markers CEA, CA 19-9, CA 72-4 and CYFRA 21-1 were analyzed in a group of apparently healthy subjects (n=232) in Kuwait using the Elecsys Relecsys 1010 analyzer. The distribution of the tumour marker levels was analyzed separately in Kuwaitis (n=103), non-Kuwaitis (n=129), smokers (n=68), non-smokers (n=164), males (n=138) and females (n=94). The distribution of CEA was significantly different in Kuwaitis vs. non-Kuwaitis in the total population (p=0.033) and in non-smokers (p=0.049); in males vs. females in the total population (p<0.0001) and in non-smokers (p=0.0002); and in smokers vs. non-smokers in the total population (p<0.0001) using the non-parametric Mann-Whitney U test. None of the other tumour markers showed significant differences in the subgroups. The upper reference level was defined as the 95th percentile of the normal values in each group. A higher reference level of CEA was observed in smokers (vs. non-smokers) in the total population. Also higher reference levels of CEA were observed in males (vs. females) both in the total population and in non-smokers. In the total population the respective reference levels were: CEA: 4.4 microg/L, CA 19-9: 35 kU/L, CA 72.4: 2.4 kU/L, and CYFRA 21.1: 2.1 microg/L. These results were compared with data in the kit inserts and literature data. The impact of 95th percentiles in a local heterogeneous population is discussed.

  1. Associated factors for higher lead and cadmium blood levels, and reference values derived from general population of São Paulo, Brazil.

    PubMed

    Kira, Carmen Silvia; Sakuma, Alice Momoyo; De Capitani, Eduardo Mello; de Freitas, Clarice Umbelino; Cardoso, Maria Regina Alves; Gouveia, Nelson

    2016-02-01

    Human activities are associated with emissions of various metals into the environment, among which the heavy metals lead and cadmium stand out, as they pose a risk to human life even at low concentrations. Thus, accurate knowledge of the levels of these metals exhibited by the overall population, including children, is important. The aim of this study was to estimate the concentrations of lead and cadmium in the blood of adults, adolescents and children residing in the city of São Paulo, assess factors associated with higher lead and cadmium blood levels, and to establish reference values for this population. The study sample consisted of 669 adults over 20 years old, 264 adolescents aged 12 to 19 years old and 391 children under 11 years old from both genders. The samples were collected at the end of 2007 and during 2008 in different city zones. Higher blood lead concentration was significantly associated with gender, smoking, offal intake, area of residence and age. The blood cadmium concentration was significantly associated with gender, smoking, consumption of distilled beverages and age. The reference values of lead and cadmium established for adults above 20 years old were 33 μg/L and 0.6 μg/L, respectively, for adolescents (12 to 19 years old) were 31 μg/L and 0.6 μg/L, respectively and for children under 11 years old were 29 μg/L and 0.2 μg/L, respectively. The results of this study indicate that the exposure levels of the investigated population to lead and cadmium are low.

  2. Comparison of end-tidal carbon dioxide and arterial blood bicarbonate levels in patients with metabolic acidosis referred to emergency medicine

    PubMed Central

    Taghizadieh, Ali; Pouraghaei, Mahboub; Moharamzadeh, Payman; Ala, Alireza; Rahmani, Farzad; Basiri Sofiani, Karim

    2016-01-01

    Introduction: The routine and gold standard method to diagnose of acid – base disturbance is arterial blood gas (ABG) sampling. Capnography could be used to measure the end-tidal carbon dioxide (ETCO2) levels and ETco2 has a close correlation with the PaCo2. The aim of this study was comparison the ETco2 and arterial blood bicarbonate levels in patients with metabolic acidosis. Methods: In a descriptive-analytical study that performed in Emergency Department of Emam Reza Medical Research and Training Hospital of Tabriz on patients with metabolic acidosis, ETco2 level and blood bicarbonate levels in 262 patients were evaluated. Results: Mean of ETco2 and Hco3 levels in patients with metabolic acidosis were 22.29 ± 4.15 and 12.78 ± 3.83, respectively. In all patients, the significant direct linear relationship was found between ETco2 with Hco3 (r = 0.553, P < 0.001). We had 4 groups of patients with metabolic acidosis, also there is a significant direct linear relationship between the ETCo2 and the Hco3 level of arterial blood in patients with renal failure (P < 0.001 and r = 0.551), sepsis (P < 0.001 and r = 0.431), drug toxicity (P < 0.001 and r = 0.856), and ketoacidosis (DKA) (P < 0.001 and r = 0.559). Conclusion: According to the results of this study, capnography can be used for primary diagnosis of metabolic acidosis in spontaneously breathing patients who referred to the emergency wards, however, the ABG must be considered as the gold standard tool for diagnosis and guiding the treatment. PMID:27777693

  3. Evaluation of serum levels in T3, T4 and TSH in beta-thalassemic patients referred to the Abuzar hospital in Ahwaz

    PubMed Central

    Asad, Zari Tahannejad; Ghazanfari, Majid; Naleini, Seyyed Nima; Sabagh, Azam; Kooti, Wesam

    2016-01-01

    Introduction Regarding the functioning of the endocrine system, and especially in the thyroid of patients with thalassemia, multiple studies in different parts of the world have reported conflicting results. The aim of this study was to assess the levels of thyroid hormones and TSH in beta-thalassemic patients in the city of Ahwaz. Methods In this matched case-control study, 105 patients in the case group and 105 subjects as controls were randomly selected from clients referred to the Abuzar hospital in 2015–2016. Serum levels of T3, T4, and TSH hormones were measured using ELISA. Data was processed with the SPSS15 software and tested by using independent t-tests and logistic regression. Results The study results showed that the serum level of T3 hormone did not significantly differ between the two groups (p> 0.05). Whereas the serum level of T4 was lower in the case group, compared to the controls, which was statistically significant (p <0.05). The serum level of thyroid stimulating hormone (TSH) in the case group was higher than the control group, and this difference was statistically significant (p <0.05). Logistic regression analysis showed significant differences in serum levels of T4 (OR: 0.58) and TSH (OR: 1.57) between the case and control groups (p<0.05). Conclusion Hypothyroidism is clear in patients with beta thalassemia. With regard to the possible effect of iron on the disorder, a blood transfusion schedule should be performed at intervals, and the desferal injection program should be done regularly to prevent hemochromatosis in patients with thalassemia major due to the effect of accumulation of iron on thyroid function and detection of hypothyroidism. This course of action will prevent incidence of this complication in patients with thalassemia major.

  4. Evaluation of serum levels in T3, T4 and TSH in beta-thalassemic patients referred to the Abuzar hospital in Ahwaz

    PubMed Central

    Asad, Zari Tahannejad; Ghazanfari, Majid; Naleini, Seyyed Nima; Sabagh, Azam; Kooti, Wesam

    2016-01-01

    Introduction Regarding the functioning of the endocrine system, and especially in the thyroid of patients with thalassemia, multiple studies in different parts of the world have reported conflicting results. The aim of this study was to assess the levels of thyroid hormones and TSH in beta-thalassemic patients in the city of Ahwaz. Methods In this matched case-control study, 105 patients in the case group and 105 subjects as controls were randomly selected from clients referred to the Abuzar hospital in 2015–2016. Serum levels of T3, T4, and TSH hormones were measured using ELISA. Data was processed with the SPSS15 software and tested by using independent t-tests and logistic regression. Results The study results showed that the serum level of T3 hormone did not significantly differ between the two groups (p> 0.05). Whereas the serum level of T4 was lower in the case group, compared to the controls, which was statistically significant (p <0.05). The serum level of thyroid stimulating hormone (TSH) in the case group was higher than the control group, and this difference was statistically significant (p <0.05). Logistic regression analysis showed significant differences in serum levels of T4 (OR: 0.58) and TSH (OR: 1.57) between the case and control groups (p<0.05). Conclusion Hypothyroidism is clear in patients with beta thalassemia. With regard to the possible effect of iron on the disorder, a blood transfusion schedule should be performed at intervals, and the desferal injection program should be done regularly to prevent hemochromatosis in patients with thalassemia major due to the effect of accumulation of iron on thyroid function and detection of hypothyroidism. This course of action will prevent incidence of this complication in patients with thalassemia major. PMID:27648188

  5. The association between non-alcoholic fatty liver disease and carotid atherosclerosis in subjects with within-reference range alanine aminotransferase levels.

    PubMed

    Kim, Kyung-Soo; Oh, Hyun-Ju; Kim, Dae-Jung; Kim, Soo-Kyung; Park, Seok Won; Cho, Yong-Wook; Huh, Kap-Bum

    2013-01-01

    Our aim was to investigate whether the evaluation of non-alcoholic fatty liver disease (NAFLD) by ultrasound provides additional benefit in assessing carotid atherosclerotic burden in subjects with alanine aminotransferase (ALT) concentrations within the reference range. This was a cross-sectional analysis of 769 healthy individuals (326 men and 443 women) with an ALT concentration ≤ 40 IU/L and alcohol consumption < 140 g/week. Mean carotid artery intima-media thickness (C-IMT) was measured using ultrasound. NAFLD was defined as a mild or greater degree of hepatic steatosis on ultrasound. Although all subjects had an ALT concentration within the reference range, the prevalence of NAFLD increased with increasing quartiles of ALT concentration (27.1%, 40.0%, 54.7%, 75.3% in men, P for trend < 0.001; 22.0%, 34.4%, 35.7%, 55.0% in women, P for trend < 0.001). In the 3rd and 4th quartiles of ALT concentration, women with NAFLD had a significantly higher C-IMT than those without NAFLD (0.671±0.019 mm vs. 0.742±0.025 mm, P=0.023 in Q3; 0.651±0.023 mm vs. 0.737±0.021 mm, P=0.005 in Q4). These differences remained significant even after adjusting for a broad spectrum of potential confounders. In contrast, although men with NAFLD tended to have a higher C-IMT than those without NAFLD in each quartile, these differences were not statistically significant. Women with an upper normal range ALT concentration showed increased C-IMT only when they had NAFLD. Therefore, in women with an elevated ALT level within the reference range, further evaluation for NAFLD, such as liver ultrasound, could potentially identify those patients at high risk for cardiovascular disease.

  6. A comparison of levels of bat flight and foraging activity at 10 meters and 30 meters above drained Carolina bays and reference bays, prior to bay restoration.

    SciTech Connect

    Menzel, Michael, A.; Ford, W., Mark; Edwards, John, W.; Kilgo, John, C.

    2001-08-01

    A technical report of a monitoring study of bat flight and foraging activity above drained and undrained Carolina bays at the Savannah River Site (SRS), located near Aiken, South Carolina. In order to determine if the vegetational community type or structure of the forest community surrounding the bays affected bat activity levels, bat activity was monitored over 3 drained and 3 undrained reference bays surrounded by pine/mixed hardwood communities and 3 drained and 3 undrained reference bays surrounded by pine monocultures. Bat activity was monitored using time expansion bat detectors. Calls were recorded to Sony Professional tape recorders (Sony WMD3). Detectors positioned at 10 m heights were linked directly to the tape recorders. Time expansion radiomicrophones were used to monitor activity at 30 m heights. The radiomicrophones were attached to 2-m diameter helium balloons and suspended approximately 30 m above the forest floor. Calls detected by the radiomicrophones were transmitted via a FM narrowband frequency to a scanner on the ground.

  7. Experimental exposure to cadmium affects metallothionein-like protein levels but not survival and growth in wolf spiders from polluted and reference populations.

    PubMed

    Eraly, Debbie; Hendrickx, Frederik; Bervoets, Lieven; Lens, Luc

    2010-06-01

    Both local adaptation and acclimation in tolerance mechanisms may allow populations to persist under metal pollution. However, both mechanisms are presumed to incur (energetic) costs and to trade-off with other life-history traits. To test this hypothesis, we exposed Pardosa saltans (Lycosidae) spiderlings originating from metal-polluted and unpolluted sites to a controlled cadmium (Cd) treatment, and compared contents of metal-binding metallothionein-like proteins (MTLPs), internal metal concentrations, and individual survival and growth rates with a reference treatment. While increased MTLP concentrations in offspring originating from both polluted and unpolluted populations upon exposure indicates a plastic tolerance mechanism, survival and growth rates remain largely unaffected, independent of the population of origin. However, MTLP and Cd concentrations were not significantly correlated. We suggest that MTLP production may be an important mechanism enabling P. saltans populations to persist in ecosystems polluted with heavy metals above a certain level.

  8. Evaluation of three reference genes of Escherichia coli for mRNA expression level normalization in view of salt and organic acid stress exposure in food.

    PubMed

    Peng, Silvio; Stephan, Roger; Hummerjohann, Jörg; Tasara, Taurai

    2014-06-01

    Escherichia coli can adapt to various stress conditions encountered in food through induction of stress response genes encoding proteins that counteract the respective stresses. To understand the impact and the induction of these genes under food-associated stresses, changes in the levels of their mRNA expression in response to such stresses can be analysed. Relative quantification of mRNA levels by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) requires normalization to reference genes with stable expression under the experimental conditions being investigated. We examined the validity of three housekeeping genes (cysG, hcaT and rssA) among E. coli strains exposed to salt and organic acid stress. The rssA gene was shown to be the most stably expressed gene under such stress adaptation experimental models. The cysG gene was the least stable, whereas the hcaT gene showed similar interstrain variability as rssA but lower expression stability in the different stress adaptation models.

  9. Reference Point Heterogeneity.

    PubMed

    Terzi, Ayse; Koedijk, Kees; Noussair, Charles N; Pownall, Rachel

    2016-01-01

    It is well-established that, when confronted with a decision to be taken under risk, individuals use reference payoff levels as important inputs. The purpose of this paper is to study which reference points characterize decisions in a setting in which there are several plausible reference levels of payoff. We report an experiment, in which we investigate which of four potential reference points: (1) a population average payoff level, (2) the announced expected payoff of peers in a similar decision situation, (3) a historical average level of earnings that others have received in the same task, and (4) an announced anticipated individual payoff level, best describes decisions in a decontextualized risky decision making task. We find heterogeneity among individuals in the reference points they employ. The population average payoff level is the modal reference point, followed by experimenter's stated expectation of a participant's individual earnings, followed in turn by the average earnings of other participants in previous sessions of the same experiment. A sizeable share of individuals show multiple reference points simultaneously. The reference point that best fits the choices of the individual is not affected by a shock to her income. PMID:27672374

  10. Reference Point Heterogeneity

    PubMed Central

    Terzi, Ayse; Koedijk, Kees; Noussair, Charles N.; Pownall, Rachel

    2016-01-01

    It is well-established that, when confronted with a decision to be taken under risk, individuals use reference payoff levels as important inputs. The purpose of this paper is to study which reference points characterize decisions in a setting in which there are several plausible reference levels of payoff. We report an experiment, in which we investigate which of four potential reference points: (1) a population average payoff level, (2) the announced expected payoff of peers in a similar decision situation, (3) a historical average level of earnings that others have received in the same task, and (4) an announced anticipated individual payoff level, best describes decisions in a decontextualized risky decision making task. We find heterogeneity among individuals in the reference points they employ. The population average payoff level is the modal reference point, followed by experimenter's stated expectation of a participant's individual earnings, followed in turn by the average earnings of other participants in previous sessions of the same experiment. A sizeable share of individuals show multiple reference points simultaneously. The reference point that best fits the choices of the individual is not affected by a shock to her income. PMID:27672374

  11. Reference Point Heterogeneity

    PubMed Central

    Terzi, Ayse; Koedijk, Kees; Noussair, Charles N.; Pownall, Rachel

    2016-01-01

    It is well-established that, when confronted with a decision to be taken under risk, individuals use reference payoff levels as important inputs. The purpose of this paper is to study which reference points characterize decisions in a setting in which there are several plausible reference levels of payoff. We report an experiment, in which we investigate which of four potential reference points: (1) a population average payoff level, (2) the announced expected payoff of peers in a similar decision situation, (3) a historical average level of earnings that others have received in the same task, and (4) an announced anticipated individual payoff level, best describes decisions in a decontextualized risky decision making task. We find heterogeneity among individuals in the reference points they employ. The population average payoff level is the modal reference point, followed by experimenter's stated expectation of a participant's individual earnings, followed in turn by the average earnings of other participants in previous sessions of the same experiment. A sizeable share of individuals show multiple reference points simultaneously. The reference point that best fits the choices of the individual is not affected by a shock to her income.

  12. Patient radiation doses in interventional cardiology in the U.S.: Advisory data sets and possible initial values for U.S. reference levels

    SciTech Connect

    Miller, Donald L.; Hilohi, C. Michael; Spelic, David C.

    2012-10-15

    Purpose: To determine patient radiation doses from interventional cardiology procedures in the U.S and to suggest possible initial values for U.S. benchmarks for patient radiation dose from selected interventional cardiology procedures [fluoroscopically guided diagnostic cardiac catheterization and percutaneous coronary intervention (PCI)]. Methods: Patient radiation dose metrics were derived from analysis of data from the 2008 to 2009 Nationwide Evaluation of X-ray Trends (NEXT) survey of cardiac catheterization. This analysis used deidentified data and did not require review by an IRB. Data from 171 facilities in 30 states were analyzed. The distributions (percentiles) of radiation dose metrics were determined for diagnostic cardiac catheterizations, PCI, and combined diagnostic and PCI procedures. Confidence intervals for these dose distributions were determined using bootstrap resampling. Results: Percentile distributions (advisory data sets) and possible preliminary U.S. reference levels (based on the 75th percentile of the dose distributions) are provided for cumulative air kerma at the reference point (K{sub a,r}), cumulative air kerma-area product (P{sub KA}), fluoroscopy time, and number of cine runs. Dose distributions are sufficiently detailed to permit dose audits as described in National Council on Radiation Protection and Measurements Report No. 168. Fluoroscopy times are consistent with those observed in European studies, but P{sub KA} is higher in the U.S. Conclusions: Sufficient data exist to suggest possible initial benchmarks for patient radiation dose for certain interventional cardiology procedures in the U.S. Our data suggest that patient radiation dose in these procedures is not optimized in U.S. practice.

  13. Pedo-geochemical baseline content levels and soil quality reference values of trace elements in soils from the Mediterranean (Castilla La Mancha, Spain)

    NASA Astrophysics Data System (ADS)

    Ballesta, Raimundo; Bueno, Paz; Rubi, Juan; Giménez, Rosario

    2010-12-01

    To evaluate trace element soil contamination, geochemical baseline contents and reference values need to be established. Pedo-geochemical baseline levels of trace elements in 72 soil samples of 24 soil profiles from the Mediterranean, Castilla La Mancha, are assessed and soil quality reference values are calculated. Reference value contents (in mg kg-1) were: Sc 50.8; V 123.2; Cr 113.4; Co 20.8; Ni 42.6; Cu 27.0; Zn 86.5; Ga 26.7; Ge 1.3; As 16.7; Se 1.4; Br 20.1; Rb 234.7; Sr 1868.4; Y 38.3; Zr 413.1; Nb 18.7; Mo 2.0; Ag 7.8; Cd 4.4; Sn 8.7; Sb 5.7; I 25.4; Cs 14.2; Ba 1049.3; La 348.4; Ce 97.9; Nd 40.1; Sm 10.7; Yb 4.2; Hf 10.0; Ta 4.0; W 5.5; Tl 2.3; Pb 44.2; Bi 2.2; Th 21.6; U 10.3. The contents obtained for some elements are below or close to the detection limit: Co, Ge, Se, Mo, Ag, Cd, Sb, Yb, Hf, Ta, W, Tl and Bi. The element content ranges (the maximum value minus the minimum value) are: Sc 55.0, V 196.0, Cr 346.0, Co 64.4, Ni 188.7, Cu 49.5, Zn 102.3, Ga 28.7, Ge 1.5, As 26.4, Se 0.9, Br 33.0 Rb 432.7, Sr 3372.6, Y 39.8, Zr 523.2, Nb 59.7, Mo 3.9, Ag 10.1, Cd 1.8, Sn 75.2, Sb 9.9, I 68.0, Cs 17.6, Ba 1394.9, La 51.3, Ce 93.5, Nd 52.5, Sm 11.2, Yb 4.2, Hf 11.3, Ta 6.3, W 5.2, Tl 2.1, Pb 96.4, Bi 3.0, Th 24.4, U 16.4 (in mg kg-1). The spatial distribution of the elements was affected mainly by the nature of the bedrock and by pedological processes. The upper limit of expected background variation for each trace element in the soil is documented, as is its range as a criterion for evaluating which sites may require decontamination.

  14. Reference Assessment

    ERIC Educational Resources Information Center

    Bivens-Tatum, Wayne

    2006-01-01

    This article presents interesting articles that explore several different areas of reference assessment, including practical case studies and theoretical articles that address a range of issues such as librarian behavior, patron satisfaction, virtual reference, or evaluation design. They include: (1) "Evaluating the Quality of a Chat Service"…

  15. Reference Revolutions.

    ERIC Educational Resources Information Center

    Mason, Marilyn Gell

    1998-01-01

    Describes developments in Online Computer Library Center (OCLC) electronic reference services. Presents a background on networked cataloging and the initial implementation of reference services by OCLC. Discusses the introduction of OCLC FirstSearch service, which today offers access to over 65 databases, future developments in integrated…

  16. SU-E-P-08: Establishment of Local Diagnostic Reference Levels of Routine Abdomen Exam in Computed Tomography According to Body Weight

    SciTech Connect

    Wang, H; Wang, Y; Weng, H

    2015-06-15

    Purpose: The national diagnostic reference levels (NDRLs) is an efficient, concise and powerful standard for optimizing radiation protection of a patient. However, for each hospital the dose-reducing potential of focusing on establishment of local DRLs (LDRLs). A lot of study reported that Computed tomography exam contributed majority radiation dose in different medical modalities, therefore, routine abdomen CT exam was choose in initial pilot study in our study. Besides the mAs of routine abdomen CT exam was decided automatic exposure control by linear attenuation is relate to body shape of patient. In this study we would like to establish the local diagnostic reference levels of routine abdomen exam in computed tomography according to body weight of patient. Methods and Materials: There are two clinical CT scanners (a Toshiba Aquilion and a Siemens Sensation) were performed in this study. For CT examinations the basic recommended dosimetric quantity is the Computed Tomography Dose Index (CTDI). The patient sample involved 82 adult patients of both sexes and divided into three groups by their body weight (50–60 kg, 60–70 kg, 70–80 kg).Carried out the routine abdomen examinations, and all exposure parameters have been collected and the corresponding CTDIv and DLP values have been determined. The average values were compared with the European DRLs. Results: The majority of patients (75%) were between 50–70 Kg of body weight, the numbers of patient in each group of weight were 40–50:7; 50–60:29; 60–70:33; 70–80:13. The LDRLs in each group were 10.81mGy, 14.46mGy, 20.27mGy and 21.04mGy, respectively. The DLP were 477mGy, 630mGy, 887mGy and 959mGy, respectively. No matter which group the LDRLs were lower than European DRLs. Conclusions: We would like to state that this was a pioneer work in local hospital in Chiayi. We hope that this may lead the way to further developments in Taiwan.

  17. Radiation dose in coronary angiography and intervention: initial results from the establishment of a multi-centre diagnostic reference level in Queensland public hospitals

    SciTech Connect

    Crowhurst, James A; Whitby, Mark; Thiele, David; Halligan, Toni; Westerink, Adam; Crown, Suzanne; Milne, Jillian

    2014-09-15

    Radiation dose to patients undergoing invasive coronary angiography (ICA) is relatively high. Guidelines suggest that a local benchmark or diagnostic reference level (DRL) be established for these procedures. This study sought to create a DRL for ICA procedures in Queensland public hospitals. Data were collected for all Cardiac Catheter Laboratories in Queensland public hospitals. Data were collected for diagnostic coronary angiography (CA) and single-vessel percutaneous intervention (PCI) procedures. Dose area product (P{sub KA}), skin surface entrance dose (K{sub AR}), fluoroscopy time (FT), and patient height and weight were collected for 3 months. The DRL was set from the 75th percentile of the P{sub KA.} 2590 patients were included in the CA group where the median FT was 3.5 min (inter-quartile range = 2.3–6.1). Median K{sub AR} = 581 mGy (374–876). Median P{sub KA} = 3908 uGym{sup 2} (2489–5865) DRL = 5865 uGym{sup 2}. 947 patients were included in the PCI group where median FT was 11.2 min (7.7–17.4). Median K{sub AR} = 1501 mGy (928–2224). Median P{sub KA} = 8736 uGym{sup 2} (5449–12,900) DRL = 12,900 uGym{sup 2}. This study established a benchmark for radiation dose for diagnostic and interventional coronary angiography in Queensland public facilities.

  18. Ready Reference.

    ERIC Educational Resources Information Center

    Koltay, Emery

    1999-01-01

    Includes the following ready reference information: "Publishers' Toll-Free Telephone Numbers"; "How to Obtain an ISBN (International Standard Book Number)"; "How to Obtain an ISSN (International Standard Serial Number)"; and "How to Obtain an SAN (Standard Address Number)". (AEF)

  19. EPA QUICK REFERENCE GUIDES

    EPA Science Inventory

    EPA Quick Reference Guides are compilations of information on chemical and biological terrorist agents. The information is presented in consistent format and includes agent characteristics, release scenarios, health and safety data, real-time field detection, effect levels, samp...

  20. Reference Materials

    NASA Astrophysics Data System (ADS)

    Merkus, Henk G.

    Reference materials for measurement of particle size and porosity may be used for calibration or qualification of instruments or for validation of operating procedures or operators. They cover a broad range of materials. On the one hand there are the certified reference materials, for which governmental institutes have certified one or more typical size or porosity values. Then, there is a large group of reference materials from commercial companies. And on the other hand there are typical products in a given line of industry, where size or porosity values come from the analysis laboratory itself or from some round-robin test in a group of industrial laboratories. Their regular application is essential for adequate quality control of particle size and porosity measurement, as required in e.g., ISO 17025 on quality management. In relation to this, some quality requirements for certification are presented.

  1. Differential responses of sexual and asexual Artemia to genotoxicity by a reference mutagen: Is the comet assay a reliable predictor of population level responses?

    PubMed

    Sukumaran, Sandhya; Grant, Alastair

    2013-05-01

    The impact of chronic genotoxicity to natural populations is always questioned due to their reproductive surplus. We used a comet assay to quantify primary DNA damage after exposure to a reference mutagen ethyl methane sulfonate in two species of crustacean with different reproductive strategies (sexual Artemia franciscana and asexual Artemia parthenogenetica). We then assessed whether this predicted individual performance and population growth rate over three generations. Artemia were exposed to different chronic concentrations (0.78mM, 1.01mM, 1.24mM and 1.48mM) of ethyl methane sulfonate from instar 1 onwards for 3 h, 24 h, 7 days, 14 days and 21 days and percentage tail DNA values were used for comparisons between species. The percentage tail DNA values showed consistently elevated values up to 7 days and showed a reduction from 14 days onwards in A. franciscana. Whilst in A. parthenogenetica such a reduction was evident on 21 days assessment. The values of percentage tail DNA after 21 days were compared with population level fitness parameters, growth, survival, fecundity and population growth rate to know whether primary DNA damage as measured by comet assay is a reliable biomarker. Substantial increase in tail DNA values was associated with substantial reductions in all the fitness parameters in the parental generation of A. franciscana and parental, F1 and F2 generations of A. parthenogenetica. So comet results were more predictive in asexual species over generations. These results pointed to the importance of predicting biomarker responses from multigenerational consequences considering life history traits and reproductive strategies in ecological risk assessments.

  2. Cross-Platform Microarray Meta-Analysis for the Mouse Jejunum Selects Novel Reference Genes with Highly Uniform Levels of Expression

    PubMed Central

    Meyer, Florian R. L.; Grausgruber, Heinrich; Binter, Claudia; Mair, Georg E.; Guelly, Christian; Vogl, Claus; Steinborn, Ralf

    2013-01-01

    Reference genes (RGs) with uniform expression are used for normalization of reverse transcription quantitative PCR (RT-qPCR) data. Their optimization for a specific biological context, e.g. a specific tissue, has been increasingly considered. In this article, we compare RGs identified by expression data meta-analysis restricted to the context tissue, the jejunum of Mus musculus domesticus, i) to traditional RGs, ii) to expressed interspersed repeated DNA elements, and iii) to RGs identified by meta-analysis of expression data from diverse tissues and conditions. To select the set of candidate RGs, we developed a novel protocol for the cross-platform meta-analysis of microarray data. The expression stability of twenty-four putative RGs was analysed by RT-qPCR in at least 14 jejunum samples of the mouse strains C57Bl/6N, CD1, and OF1. Across strains, the levels of expression of the novel RGs Plekha7, Zfx, and Ube2v1 as well as of Oaz1 varied less than two-fold irrespective of genotype, sex or their combination. The gene set consisting of Plekha7 and Oaz1 showed superior expression stability analysed with the tool RefFinder. The novel RGs are functionally diverse. This facilitates expression studies over a wide range of conditions. The highly uniform expression of the optimized RGs in the jejunum points towards their involvement in tightly regulated pathways in this tissue. We also applied our novel protocol of cross-microarray platform meta-analysis to the identification of RGs in the duodenum, the ileum and the entire small intestine. The selection of RGs with improved expression stability in a specific biological context can reduce the number of RGs for the normalization step of RT-qPCR expression analysis, thus reducing the number of samples and experimental costs. PMID:23671661

  3. Poroelastic references

    SciTech Connect

    Morency, Christina

    2014-12-12

    This file contains a list of relevant references on the Biot theory (forward and inverse approaches), the double-porosity and dual-permeability theory, and seismic wave propagation in fracture porous media, in RIS format, to approach seismic monitoring in a complex fractured porous medium such as Brady?s Geothermal Field.

  4. Ready Reference.

    ERIC Educational Resources Information Center

    Koltay, Emery

    2001-01-01

    Includes four articles that relate to ready reference, including a list of publishers' toll-free telephone numbers and Web sites; how to obtain an ISBN (International Standard Book Number) and an ISSN (International Standard Serial Number); and how to obtain an SAN (Standard Address Number), for organizations that are involved in the book…

  5. Nicotine, acetanilide and urea multi-level2H-,13C- and15N-abundance reference materials for continuous-flow isotope ratio mass spectrometry

    USGS Publications Warehouse

    Schimmelmann, A.; Albertino, A.; Sauer, P.E.; Qi, H.; Molinie, R.; Mesnard, F.

    2009-01-01

    Accurate determinations of stable isotope ratios require a calibration using at least two reference materials with different isotopic compositions to anchor the isotopic scale and compensate for differences in machine slope. Ideally, the S values of these reference materials should bracket the isotopic range of samples with unknown S values. While the practice of analyzing two isotopically distinct reference materials is common for water (VSMOW-SLAP) and carbonates (NBS 19 and L-SVEC), the lack of widely available organic reference materials with distinct isotopic composition has hindered the practice when analyzing organic materials by elemental analysis/isotope ratio mass spectrometry (EA-IRMS). At present only L-glutamic acids USGS40 and USGS41 satisfy these requirements for ??13C and ??13N, with the limitation that L-glutamic acid is not suitable for analysis by gas chromatography (GC). We describe the development and quality testing of (i) four nicotine laboratory reference materials for on-line (i.e. continuous flow) hydrogen reductive gas chromatography-isotope ratio mass-spectrometry (GC-IRMS), (ii) five nicotines for oxidative C, N gas chromatography-combustion-isotope ratio mass-spectrometry (GC-C-IRMS, or GC-IRMS), and (iii) also three acetanilide and three urea reference materials for on-line oxidative EA-IRMS for C and N. Isotopic off-line calibration against international stable isotope measurement standards at Indiana University adhered to the 'principle of identical treatment'. The new reference materials cover the following isotopic ranges: ??2Hnicotine -162 to -45%o, ??13Cnicotine -30.05 to +7.72%, ?? 15Nnicotine -6.03 to +33.62%; ??15N acetanilide +1-18 to +40.57%; ??13Curea -34.13 to +11.71%, ??15Nurea +0.26 to +40.61% (recommended ?? values refer to calibration with NBS 19, L-SVEC, IAEA-N-1, and IAEA-N-2). Nicotines fill a gap as the first organic nitrogen stable isotope reference materials for GC-IRMS that are available with different ??13N

  6. Nicotine, acetanilide and urea multi-level 2H-, 13C- and 15N-abundance reference materials for continuous-flow isotope ratio mass spectrometry.

    PubMed

    Schimmelmann, Arndt; Albertino, Andrea; Sauer, Peter E; Qi, Haiping; Molinie, Roland; Mesnard, François

    2009-11-01

    Accurate determinations of stable isotope ratios require a calibration using at least two reference materials with different isotopic compositions to anchor the isotopic scale and compensate for differences in machine slope. Ideally, the delta values of these reference materials should bracket the isotopic range of samples with unknown delta values. While the practice of analyzing two isotopically distinct reference materials is common for water (VSMOW-SLAP) and carbonates (NBS 19 and L-SVEC), the lack of widely available organic reference materials with distinct isotopic composition has hindered the practice when analyzing organic materials by elemental analysis/isotope ratio mass spectrometry (EA-IRMS). At present only L-glutamic acids USGS40 and USGS41 satisfy these requirements for delta13C and delta15N, with the limitation that L-glutamic acid is not suitable for analysis by gas chromatography (GC). We describe the development and quality testing of (i) four nicotine laboratory reference materials for on-line (i.e. continuous flow) hydrogen reductive gas chromatography-isotope ratio mass-spectrometry (GC-IRMS), (ii) five nicotines for oxidative C, N gas chromatography-combustion-isotope ratio mass-spectrometry (GC-C-IRMS, or GC-IRMS), and (iii) also three acetanilide and three urea reference materials for on-line oxidative EA-IRMS for C and N. Isotopic off-line calibration against international stable isotope measurement standards at Indiana University adhered to the 'principle of identical treatment'. The new reference materials cover the following isotopic ranges: delta2H(nicotine) -162 to -45 per thousand, delta13C(nicotine) -30.05 to +7.72 per thousand, delta15N(nicotine) -6.03 to +33.62 per thousand; delta15N(acetanilide) +1.18 to +40.57 per thousand; delta13C(urea) -34.13 to +11.71 per thousand, delta15N(urea) +0.26 to +40.61 per thousand (recommended delta values refer to calibration with NBS 19, L-SVEC, IAEA-N-1, and IAEA-N-2). Nicotines fill a gap as

  7. Patient Dose During Carotid Artery Stenting With Embolic-Protection Devices: Evaluation With Radiochromic Films and Related Diagnostic Reference Levels According to Factors Influencing the Procedure

    SciTech Connect

    D'Ercole, Loredana; Quaretti, Pietro; Cionfoli, Nicola; Klersy, Catherine; Bocchiola, Milena; Rodolico, Giuseppe; Azzaretti, Andrea; Lisciandro, Francesco; Cascella, Tommaso; Zappoli Thyrion, Federico

    2013-04-15

    To measure the maximum entrance skin dose (MESD) on patients undergoing carotid artery stenting (CAS) using embolic-protection devices, to analyze the dependence of dose and exposure parameters on anatomical, clinical, and technical factors affecting the procedure complexity, to obtain some local diagnostic reference levels (DRLs), and to evaluate whether overcoming DRLs is related to procedure complexity. MESD were evaluated with radiochromic films in 31 patients (mean age 72 {+-} 7 years). Five of 33 (15 %) procedures used proximal EPD, and 28 of 33 (85 %) procedures used distal EPD. Local DRLs were derived from the recorded exposure parameters in 93 patients (65 men and 28 women, mean age 73 {+-} 9 years) undergoing 96 CAS with proximal (33 %) or distal (67 %) EPD. Four bilateral lesions were included. MESD values (mean 0.96 {+-} 0.42 Gy) were <2 Gy without relevant dependence on procedure complexity. Local DRL values for kerma area product (KAP), fluoroscopy time (FT), and number of frames (N{sub FR}) were 269 Gy cm{sup 2}, 28 minutes, and 251, respectively. Only simultaneous bilateral treatment was associated with KAP (odds ratio [OR] 10.14, 95 % confidence interval [CI] 1-102.7, p < 0.05) and N{sub FR} overexposures (OR 10.8, 95 % CI 1.1-109.5, p < 0.05). Type I aortic arch decreased the risk of FT overexposure (OR 0.4, 95 % CI 0.1-0.9, p = 0.042), and stenosis {>=} 90 % increased the risk of N{sub FR} overexposure (OR 2.8, 95 % CI 1.1-7.4, p = 0.040). At multivariable analysis, stenosis {>=} 90 % (OR 2.8, 95 % CI 1.1-7.4, p = 0.040) and bilateral treatment (OR 10.8, 95 % CI 1.1-109.5, p = 0.027) were associated with overexposure for two or more parameters. Skin doses are not problematic in CAS with EPD because these procedures rarely lead to doses >2 Gy.

  8. Referring a patient and family to high-quality palliative care at the close of life: "We met a new personality... with this level of compassion and empathy".

    PubMed

    Teno, Joan M; Connor, Stephen R

    2009-02-11

    Palliative care services are increasingly available to primary care physicians for both expert consultations and services to seriously ill patients. The United States now has more than 1400 hospital-based palliative care teams and more than 4700 hospice programs. We use an illustrative case of a palliative care hospitalization and intervention for a middle-aged man with severe pain from spinal metastases to discuss 4 key questions that a primary care physician faces in caring for the seriously ill patient with difficult symptom management: (1) Should I refer a patient to a hospital-based palliative care team or to hospice services for difficult symptom management? (2) If the patient is referred to a hospital-based palliative care team, what should I, as the primary care physician, expect? (3) When should I refer to hospice services a patient initially referred to a hospital-based palliative care team? and (4) How can I choose a hospice program that will provide competent, coordinated, and compassionate patient- and family-centered care? Primary care physicians now may choose among hospice programs, and the programs may vary in their quality of care. Validated tools to measure patient and family perceptions of the quality of hospice care are now available but progress in defining and measuring the quality of hospice care is still needed before actionable information will be available to guide the choice of hospice programs for physicians and consumers.

  9. On Development and Characterisation of a Mobile and Metrologically Traceable Reference Gas Generator for Ammonia and Other Reactive Species in Ambient Air Levels

    NASA Astrophysics Data System (ADS)

    Leuenberger, Daiana; Pascale, Céline; Guillevic, Myriam; Ackermann, Andreas; Niederhauser, Bernhard

    2016-04-01

    Ammonia NH3 in the atmosphere is the major precursor for neutralising atmospheric acids and is thus affecting not only the long-range transport of sulphur dioxide and nitrogen oxides but also stabilies secondary particulate matter. These aerosols have negative impacts on air quality and human health. Moreover, they negatively affect terrestrial ecosystems after deposition. NH3 has been included in the air quality monitoring networks and emission reduction directives of European nations. Atmospheric concentrations are in the order of 0.5-500 nmol/mol. However, the lowest substance amount fraction of available certified reference material (CRM) is 30 μmol/mol. The EMRP JRP ENV55 MetNH3 aims at overcoming this discrepancy by assessing and developing novel approaches for the production of CRM and measurement methods. The Federal Institute of Metrology METAS has developed a mobile and metrologically traceable reference gas generator for reactive gases (ReGaS1). This device is based on the specific temperature dependent permeation of the reference substance through a membrane into a flow of carrier gas and subsequent dynamic dilution to desired amount fractions. The characteristics of individual components lead to the uncertainty estimation for the generated NH3 gas mixture according to GUM, which is aimed to be <3 %. Here we present insights into the development of said instrument and results of the first performance tests. Moreover, we include results of the study on adsorption/desorption effects in dry as well as humidified matrix gas into the discussion on the generation of reference gas mixtures.

  10. Feasibility study for producing a carrot/potato matrix reference material for 11 selected pesticides at EU MRL level: material processing, homogeneity and stability assessment.

    PubMed

    Saldanha, Helena; Sejerøe-Olsen, Berit; Ulberth, Franz; Emons, Hendrik; Zeleny, Reinhard

    2012-05-01

    The feasibility for producing a matrix reference material for selected pesticides in a carrot/potato matrix was investigated. A commercially available baby food (carrot/potato-based mash) was spiked with 11 pesticides at the respective EU maximum residue limits (MRLs), and further processed by either freezing or freeze-drying. Batches of some 150 units were produced per material type. First, the materials were assessed for the relative amount of pesticide recovered after processing (ratio of pesticide concentration in the processed material to the initially spiked pesticide concentration). In addition, the materials' homogeneity (bottle-to-bottle variation), and the short-term (1 month) and mid-term (5 months) stability at different temperatures were assessed. For this, an in-house validated GC-EI-MS method operated in the SIM mode with a sample preparation procedure based on the QuEChERS ("quick, easy, cheap, effective, rugged, and safe") principle was applied. Measurements on the frozen material provided the most promising results (smallest analyte losses during production), and also freeze-drying proved to be a suitable alternative processing technique for most of the investigated pesticides. Both the frozen and the freeze-dried material showed to be sufficiently homogeneous for the intended use, and storage at -20°C for 5 months did not reveal any detectable material degradation. The results constitute an important step towards the development of a pesticide matrix reference material. PMID:26434333

  11. Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population.

    PubMed

    Tyagi, Vipin; Garg, Neha; Mustafa, M D; Banerjee, B D; Guleria, Kiran

    2015-07-01

    Organochlorine pesticides (OCPs) have been widely used in public health and agriculture programs in developed as well as developing countries, including India. Being xenoestrogenic in nature, OCPs may act as endocrine disruptors leading to preterm birth (PTB) through disturbance of normal estrogen-progesterone ratio. PTB is the leading cause of neonatal deaths worldwide. Therefore, the present study is aimed to determine the extent to which persistent environmental chemicals may accumulate in pregnant women and placenta and ascertain possible associations between exposure level and period of gestation (POG), baby weight, and/or placental weight in PTB cases. Maternal blood and placenta samples of PTB cases (n = 50) and subjects of term delivery as controls (n = 50) were collected. OCP residue levels were estimated by the gas chromatography system equipped with an electron capture detector. Significantly higher levels of α-hexachlorocyclohexane (α-HCH), β-hexachlorocyclohexane (β-HCH), dichlorodiphenyldichloroethane (DDD), and dichlorodiphenyldichloroethylene (DDE) were found in maternal blood of PTB cases as compared to control. Significantly higher levels of DDE and dichlorodiphenyltrichloroethane (DDT) were also found in placental tissue of PTB cases as compared to control group. There was a statistically significant negative correlation between maternal blood level of α-HCH and birth-weight (r = -0.299) and POG (r = -0.234). γ-Hexachlorocyclohexane (γ-HCH) and dieldrin had a negative correlation with placental weight (r = -0.401 and -0.256, respectively), and DDE and β-HCH had a negative correlation with POG (r = -0.251 and -0.229, respectively). The presence of OCPs in maternal blood and placental tissue represents prenatal exposure hazard for fetuses due to chronic bioaccumulation and poor elimination with possible deleterious effect on health.

  12. Climate Change, Sea-Level Rise and Implications for Coastal and Estuarine Shoreline Management with Particular Reference to the Ecology of Intertidal Benthic Macrofauna in NW Europe

    PubMed Central

    Fujii, Toyonobu

    2012-01-01

    In many European estuaries, extensive areas of intertidal habitats consist of bare mudflats and sandflats that harbour a very high abundance and biomass of macrobenthic invertebrates. The high stocks of macrobenthos in turn provide important food sources for the higher trophic levels such as fish and shorebirds. Climate change and associated sea-level rise will have potential to cause changes in coastal and estuarine physical properties in a number of ways and thereby influence the ecology of estuarine dependent organisms. Although the mechanisms involved in biological responses resulting from such environmental changes are complex, the ecological effects are likely to be significant for the estuarine benthic macrofauna and hence the consumers they support. This paper reviews the utilisation patterns of estuarine intertidal habitats by shorebirds, fish and crustaceans, as well as factors affecting the distribution, abundance and biomass of estuarine macrobenthos that is known to be important food source for these estuarine predators. This study also provides simple conceptual models of the likely impacts of sea-level rise on the physical and biological elements of estuarine intertidal habitats, and implications of these results are discussed in the context of sustainable long term flood and coastal management in estuarine environments. PMID:24832510

  13. Possible Correlates of Free Radicals and Free Radical Mediated Disorders in Ayurveda with Special Referance to Bhutagni Vyapara and Ama at molecular Level

    PubMed Central

    Tripathi, J.S.; Singh, R. H.

    1999-01-01

    The description of metabolic processes, operating at various levels insider the body, has been essentially covered in Ayurveda under thirteen types of Agnis and their functions at different levels, which are often compared with the enzymes and biochemical which take part in biological and / or biophysical transformations and reactions. When these Agnis, at different levels, get disordered they lead to the production of certain undesired elements or byproducts in the system, which are called as ‘Ama’ in ayurveda and are considered as very important morbid factor responsible for causation of a variety of diseases and playing key role in genesis of most of the diseases. The present article attempts to correlate the most recent concept of today's medicine i.e., Free Radical concept with that of the concept of Agni and Ama, described in Ayurveda and thereby opens newer vistas of search for remedies from Ayurvedic research, which may be helpful in the prevention and care of Free Radical Mediated Diseases. PMID:22556911

  14. Climate Change, Sea-Level Rise and Implications for Coastal and Estuarine Shoreline Management with Particular Reference to the Ecology of Intertidal Benthic Macrofauna in NW Europe.

    PubMed

    Fujii, Toyonobu

    2012-11-05

    In many European estuaries, extensive areas of intertidal habitats consist of bare mudflats and sandflats that harbour a very high abundance and biomass of macrobenthic invertebrates. The high stocks of macrobenthos in turn provide important food sources for the higher trophic levels such as fish and shorebirds. Climate change and associated sea-level rise will have potential to cause changes in coastal and estuarine physical properties in a number of ways and thereby influence the ecology of estuarine dependent organisms. Although the mechanisms involved in biological responses resulting from such environmental changes are complex, the ecological effects are likely to be significant for the estuarine benthic macrofauna and hence the consumers they support. This paper reviews the utilisation patterns of estuarine intertidal habitats by shorebirds, fish and crustaceans, as well as factors affecting the distribution, abundance and biomass of estuarine macrobenthos that is known to be important food source for these estuarine predators. This study also provides simple conceptual models of the likely impacts of sea-level rise on the physical and biological elements of estuarine intertidal habitats, and implications of these results are discussed in the context of sustainable long term flood and coastal management in estuarine environments.

  15. Selective hydride generation- cryotrapping- ICP-MS for arsenic speciation analysis at picogram levels: analysis of river and sea water reference materials and human bladder epithelial cells

    PubMed Central

    Matoušek, Tomáš; Currier, Jenna M.; Trojánková, Nikola; Saunders, R. Jesse; Ishida, María C.; González-Horta, Carmen; Musil, Stanislav; Mester, Zoltán; Stýblo, Miroslav; Dědina, Jiří

    2013-01-01

    An ultra sensitive method for arsenic (As) speciation analysis based on selective hydride generation (HG) with preconcentration by cryotrapping (CT) and inductively coupled plasma- mass spectrometry (ICP-MS) detection is presented. Determination of valence of the As species is performed by selective HG without prereduction (trivalent species only) or with L-cysteine prereduction (sum of tri- and pentavalent species). Methylated species are resolved on the basis of thermal desorption of formed methyl substituted arsines after collection at −196°C. Limits of detection of 3.4, 0.04, 0.14 and 0.10 pg mL−1 (ppt) were achieved for inorganic As, mono-, di- and trimethylated species, respectively, from a 500 μL sample. Speciation analysis of river water (NRC SLRS-4 and SLRS-5) and sea water (NRC CASS-4, CASS-5 and NASS-5) reference materials certified to contain 0.4 to 1.3 ng mL−1 total As was performed. The concentrations of methylated As species in tens of pg mL−1 range obtained by HG-CT-ICP-MS systems in three laboratories were in excellent agreement and compared well with results of HG-CT-atomic absorption spectrometry and anion exchange liquid chromatography- ICP-MS; sums of detected species agreed well with the certified total As content. HG-CT-ICP-MS method was successfully used for analysis of microsamples of exfoliated bladder epithelial cells isolated from human urine. Here, samples of lysates of 25 to 550 thousand cells contained typically tens pg up to ng of iAs species and from single to hundreds pg of methylated species, well within detection power of the presented method. A significant portion of As in the cells was found in the form of the highly toxic trivalent species. PMID:24014931

  16. Levels of toxic elements and functional structure in populations of small mammals under conditions of technogenic pollution (with reference to the bank vole)

    SciTech Connect

    Mukhacheva, S.V.; Bezel, V.S.

    1995-05-01

    The levels and the character of accumulation of heavy metals (Pb, Cd, Cu, Zn) in organs and tissues of bank voles, living under conditions of technogenic pollution (near a copper-smelting plant) and on the control territory, were studied. The fundamental distinctions in the character of accumulation of physiologically extraneous elements (lead and cadmium) and elements required for normal functioning (copper and zinc) were found. It was shown that the bank vole population responds to technogenic pollution of the environment depending on the ecological-functional features of the subpopulational groups that form this population. 4 refs., 3 figs., 2 tabs.

  17. Validation of reference genes for normalization of qPCR mRNA expression levels in Staphylococcus aureus exposed to osmotic and lactic acid stress conditions encountered during food production and preservation.

    PubMed

    Sihto, Henna-Maria; Tasara, Taurai; Stephan, Roger; Johler, Sophia

    2014-07-01

    Staphylococcus aureus represents the most prevalent cause of food-borne intoxications worldwide. While being repressed by competing bacteria in most matrices, this pathogen exhibits crucial competitive advantages during growth at high salt concentrations or low pH, conditions frequently encountered in food production and preservation. We aimed to identify reference genes that could be used to normalize qPCR mRNA expression levels during growth of S. aureus in food-related osmotic (NaCl) and acidic (lactic acid) stress adaptation models. Expression stability of nine housekeeping genes was evaluated in full (LB) and nutrient-deficient (CYGP w/o glucose) medium under conditions of osmotic (4.5% NaCl) and acidic stress (lactic acid, pH 6.0) after 2-h exposure. Among the set of candidate reference genes investigated, rplD, rpoB,gyrB, and rho were most stably expressed in LB and thus represent the most suitable reference genes for normalization of qPCR data in osmotic or lactic acid stress models in a rich medium. Under nutrient-deficient conditions, expression of rho and rpoB was highly stable across all tested conditions. The presented comprehensive data on changes in expression of various S. aureus housekeeping genes under conditions of osmotic and lactic acid stress facilitate selection of reference genes for qPCR-based stress response models.

  18. Development of national reference energy mean emission levels for the FHWA traffic noise model (FHWA TNM (trade name)), version 1.0. Final report, July 1993-November 1995

    SciTech Connect

    Fleming, G.G.; Rapoza, A.S.; Lee, C.S.Y.

    1995-11-01

    During the period, July 1993 through November 1995, the U.S. Department of Transportation , Research and Special Programs Administration, John A. Volpe National Transportation Systems Center (Volpe Center), Acoustics Facility. This report also presents the results of the study, including the measurement, data reduction and analysis procedures used to develop the Data Base. It discusses data for constant-flow and interrupted-flow roadway traffic, and data related to vehicle subsource heights. This report also presents the statistical methodology used to establish the Data Base for the FHWA TNM. Sound level regressions are presented as a function of several parameters, including vehicle speed, vehicle type, one-third octave-band frequency, roadway pavement type, roadway grade, traffic-flow condition and vehicle subsource height.

  19. Benchmarking curriculum content in entry-level health professional education with special reference to health promotion practice in physical therapy: a multi-institutional international study.

    PubMed

    Bodner, Michael E; Rhodes, Ryan E; Miller, William C; Dean, Elizabeth

    2013-10-01

    Health promotion (HP) warrants being a clinical competency for health professionals given the global burden of lifestyle-related conditions; these are largely preventable with lifestyle behavior change. Physical therapists have a practice pattern conducive to HP, including lifestyle behavior change. The extent to which HP content is included in entry-level physical therapy (PT) curricula, and how it is taught however, is unknown. The aim of this study was to benchmark lifestyle behavior HP content within entry-level curricula of international PT programs. The sampling frame included 258 accredited PT academic programs spanning six countries. An internet-based survey was used to assess HP curricular content. Descriptive questions for HP topics (smoking cessation, nutrition, weight control, alcohol consumption, exercise, and stress management) included hours allotted and instructional methods used. Chi square tests examined differences between the proportion of programs in the United States (US) and other countries (combined) for HP topics, and among HP topics regarding instructional methods. The response rate was 48 %. Most programs (>80 %) included all HP topics except alcohol consumption (65.5 % of programs). Instructional methods used were primarily theory-based; few programs (range 2.6-24.1 %) combined theory, practical and attainment of clinical competency for all HP topics (exercise prescription notwithstanding). Proportionally, more US programs included alcohol and nutrition than other countries combined. Overall, HP lifestyle behavior topics were included to varying extent; however, instructional methods used and hours allotted per topic varied across PT curricula. Universal standards of HP practice as a clinical competency are warranted within the profession.

  20. Distribution, level, pharmacology, regulation, and signaling of 5-HT6 receptors in rats and marmosets with special reference to an experimental model of parkinsonism.

    PubMed

    Zhang, Xiaoqun; Andren, Per E; Glennon, Richard A; Svenningsson, Per

    2011-06-15

    Serotonin 5-HT(6) receptors have been implicated in the regulation of cognition, locomotion, and mood, but the elucidation of their functions is complicated by conflicting data using various animal models. Here, a systematic evaluation showed that autoradiographic binding with the selective 5-HT(6) receptor antagonist [(125) I]SB-258585 was similar in marmosets and rats. In both species, [(125) I]SB-258585 binding was enriched in the caudate-putamen. Various recently developed agonists and antagonists toward 5-HT(6) receptors exhibited similarities in their abilities to displace [(125) I]SB-258585 binding in marmosets and rats. The rank order of pEC50 values were as follows: (+)EMDT-CR = EMD386088>MS-245 = 5-HT>EMDT>(-)EMDT-CR; and (+)EMDT-CR = EMD386088>5-HT = MS-245 = EMDT>(-)EMDT-CR, in marmosets and rats, respectively. Unilateral 6-hydroxydopamine lesioning of dopaminergic axons caused a significant decrease of [(125) I]SB-258585 binding in the caudate-putamen of both marmosets and rats. Nonetheless, acute administration of the 5-HT(6) receptor agonist EMDT to unilaterally 6-hydroxydopamine-lesioned rats, caused an induction of egr-1, homer, and enkephalin mRNAs in the dopamine-depleted hemisphere, indicating a supersensitization of 5-HT(6) receptors following dopamine depletion. In conclusion, this study provides evidence for significant similarities in the distribution, level, pharmacology, and regulation of 5-HT(6) receptors between rats and marmosets.

  1. Preliminary report on the geology and hydrology of Mortandad Canyon near Los Alamos, New Mexico, with reference to disposal of liquid low-level radioactive waste

    USGS Publications Warehouse

    Baltz, E.H.; Abrahams, J.H.; Purtyman, W.D.

    1963-01-01

    The U.S. Geological Survey, in cooperation with the U.S. Atomic Energy Commission and the Los Alamos Scientific Laboratory, selected the upper part of Mortandad Canyon near Los Alamos, New Mexico for a site for disposal of treated liquid low-level radioactive waste. This report summarizes the part of a study of the geology and hydrology that was done from October 1960 through June 1961. Additional work is being continued. Mortandad Canyon is a narrow east-southeast-trending canyon about 9? miles long that heads on the central part of the Pajarito Plateau at an altitude of about 7,340 feet. The canyon is tributary to the Rio Grande. The drainage area of the part of Mortandad Canyon that was investigated is about 2 square miles, and the total drainage area is about 4.9 square miles. The Pajarito Plateau is capped by the Bandelier Tuff of Pleistocene age. Mortandad Canyon is cut in the Bandelier, and alluvium covers the floor of the canyon to depths ranging from less than 1 foot to as much as 100 feet. The Bandelier is underlain by silt, sand, conglomerate, and interbedded basalt of the Santa Fe Group of Miocene, Pliocene, and Pleistocene(?) age. Some ground water is perched in the alluvium in the canyon; however, the top of the main aquifer is in the Santa Fe Group at a depth of about 990 feet below the canyon floor. Joints in the Bandelier Tuff probably were caused by shrinkage of the tuff during cooling. The joints range in width from hairline cracks to fissures several inches wide. Water can infiltrate along the open joints where the Bandelier is at the surface; however, soil, alluvial fill, and autochthonous clay inhibit infiltration on the tops of mesas and probably in the alluvium-floored canyons also. Thirty-three test holes, each less than 100 feet deep, were drilled in 10 lies across Mortandad Canyon from the western margin of the study area to just west of the Los Alamos-Santa Fe County line. Ten of the holes were cased for observation wells to measure

  2. Assessment of losses in honey yield due to the chalkbrood disease, with reference to the determination of its economic injury levels in Egypt.

    PubMed

    Zaghloul, O A; Mourad, A K; El Kady, Magda B; Nemat, F M; Morsy, M E

    2005-01-01

    In Egypt, the chalk brood (CHB) disease caused by the fungus, Ascosphaera apis Maassen started again infesting the honeybee, Apis melifera L (Hymenoptera: Apidae) colonies after a cessation pause of seven to nine years. For the first time, an attempt has been made to look into the problem of the CHB disease from the view point of assessing losses in both clover (Trifolium alexandrinum) and chinus (Chinus molus) honey yields. In this regard, two techniques were adopted. Under the natural conditions of the experimental apiary (first technique), loss in clover honey was 18.412 +/- 0.663%, on average, whereas the average loss in chinus honey was 18.332 +/- 1.536%. In the second technique of loss appraisal (artificial infection). The tested honeybee colonies were artificially infected with four sources of A. apis infection, I.e. black mummies, white mummies, pollen grains and water, in addition to controls to create the so-called "different levels of infection". The mean percentages of losses in clover honey were 30.06 +/- 1.807, 27.95 +/- 1.062; 21.13 +/- 0.987; 16.96 +/- 0.672 and 0.00 +/- 0.00 for black mummies, white mummies, pollen grains, water and control, respectively. Taking into account the relationship between number of resulted mummies in each source of infection and % loss in clover honey, it could be concluded that as the resulted mummies increased, the corresponding clover honey yield decreased in each source of infection. It was noticed that the % loss in clover honey differed as the used technique differed. For example, the percentage loss in clover honey produced from colonies exposed to the natural conditions was relatively less than that of the artificially infected ones. This has been discussed in the text. However, the causative pathogen of CHB disease resulted in serious decrease in honey production. Loss appraisal is a perquisite step for the determination of the economic injury levels (EILs). By regressing % loss in clover honey yield against

  3. Assessment of losses in honey yield due to the chalkbrood disease, with reference to the determination of its economic injury levels in Egypt.

    PubMed

    Zaghloul, O A; Mourad, A K; El Kady, Magda B; Nemat, F M; Morsy, M E

    2005-01-01

    In Egypt, the chalk brood (CHB) disease caused by the fungus, Ascosphaera apis Maassen started again infesting the honeybee, Apis melifera L (Hymenoptera: Apidae) colonies after a cessation pause of seven to nine years. For the first time, an attempt has been made to look into the problem of the CHB disease from the view point of assessing losses in both clover (Trifolium alexandrinum) and chinus (Chinus molus) honey yields. In this regard, two techniques were adopted. Under the natural conditions of the experimental apiary (first technique), loss in clover honey was 18.412 +/- 0.663%, on average, whereas the average loss in chinus honey was 18.332 +/- 1.536%. In the second technique of loss appraisal (artificial infection). The tested honeybee colonies were artificially infected with four sources of A. apis infection, I.e. black mummies, white mummies, pollen grains and water, in addition to controls to create the so-called "different levels of infection". The mean percentages of losses in clover honey were 30.06 +/- 1.807, 27.95 +/- 1.062; 21.13 +/- 0.987; 16.96 +/- 0.672 and 0.00 +/- 0.00 for black mummies, white mummies, pollen grains, water and control, respectively. Taking into account the relationship between number of resulted mummies in each source of infection and % loss in clover honey, it could be concluded that as the resulted mummies increased, the corresponding clover honey yield decreased in each source of infection. It was noticed that the % loss in clover honey differed as the used technique differed. For example, the percentage loss in clover honey produced from colonies exposed to the natural conditions was relatively less than that of the artificially infected ones. This has been discussed in the text. However, the causative pathogen of CHB disease resulted in serious decrease in honey production. Loss appraisal is a perquisite step for the determination of the economic injury levels (EILs). By regressing % loss in clover honey yield against

  4. Reference Frames and Relativity.

    ERIC Educational Resources Information Center

    Swartz, Clifford

    1989-01-01

    Stresses the importance of a reference frame in mechanics. Shows the Galilean transformation in terms of relativity theory. Discusses accelerated reference frames and noninertial reference frames. Provides examples of reference frames with diagrams. (YP)

  5. Genetics Home Reference: isolated hyperchlorhidrosis

    MedlinePlus

    ... is characterized by the excessive loss of salt (sodium chloride or NaCl) in sweat. In particular, "hyperchlorhidrosis" refers ... levels of chloride found in sweat, although both sodium and chloride are released. Because the salt is abnormally released ...

  6. SPAR reference manual update SPAR level 15

    NASA Technical Reports Server (NTRS)

    Whetstone, W. D.

    1980-01-01

    Command runstream elements are presented for analyzing structural systems that are composed of a number of cyclically symmetrical sectors. Provisions are included for systems in which each cyclically symmetrical sector also possesses a plane of reflective symmetry. The following types of analysis may be performed: static analysis with and without preload, vibrational analysis with and without preload, and buckling analysis with and without preload.

  7. Reference Service Policy Statement.

    ERIC Educational Resources Information Center

    Young, William F.

    This reference service policy manual provides general guidelines to encourage reference service of the highest possible quality and to insure uniform practice. The policy refers only to reference service in the University Libraries and is intended for use in conjunction with other policies and procedures issued by the Reference Services Division.…

  8. Generalizing indexical-functional reference

    SciTech Connect

    Schoppers, M.; Shu, R.

    1996-12-31

    The goals of situated agents generally do not specify particular objects: they require only that some suitable object should be chosen and manipulated (e.g. any red block). Situated agents engaged in deictic reference grounding, however, may well track a chosen referent object with such fixity of purpose that an unchosen object may be regarded as an obstacle even though it satisfies the agent`s goals. In earlier work this problem was bridged by hand-coding. This paper lifts the problem to the symbol level, endowing agents with perceptual referent selection actions and performing those actions as required to allow or disallow opportunistic re-selection of referents. Our work preserves the ability of situated agents to find and track specific objects, adds an ability to automatically exploit the opportunities allowed by nonspecific references, and provides a starting point for studying how much opportunistic perception is appropriate.

  9. Higher levels of phosphorylated Y1472 on GluN2B subunits in the frontal cortex of aged mice are associated with good spatial reference memory, but not cognitive flexibility.

    PubMed

    Zamzow, Daniel R; Elias, Val; Acosta, Varinia A; Escobedo, Emily; Magnusson, Kathy R

    2016-06-01

    The N-methyl-D-aspartate receptor (NMDAr) is particularly vulnerable to aging. The GluN2B subunit of the NMDAr, compared to other NMDAr subunits, suffers the greatest losses of expression in the aging brain, especially in the frontal cortex. While expression levels of GluN2B mRNA and protein in the aged brain are well documented, there has been little investigation into age-related posttranslational modifications of the subunit. In this study, we explored some of the mechanisms that may promote differences in the NMDAr complex in the frontal cortex of aged animals. Two ages of mice, 3 and 24 months, were behaviorally tested in the Morris water maze. The frontal cortex and hippocampus from each mouse were subjected to differential centrifugation followed by solubilization in Triton X-100. Proteins from Triton-insoluble membranes, Triton-soluble membranes, and intracellular membranes/cytosol were examined by Western blot. Higher levels of GluN2B tyrosine 1472 phosphorylation in frontal cortex synaptic fractions of old mice were associated with better reference learning but poorer cognitive flexibility. Levels of GluN2B phosphotyrosine 1336 remained steady, but there were greater levels of the calpain-induced 115 kDa GluN2B cleavage product on extrasynaptic membranes in these old good learners. There was an age-related increase in calpain activity, but it was not associated with better learning. These data highlight a unique aging change for aged mice with good spatial learning that might be detrimental to cognitive flexibility. This study also suggests that higher levels of truncated GluN2B on extrasynaptic membranes are not deleterious to spatial memory in aged mice.

  10. Fundamentals of Reference

    ERIC Educational Resources Information Center

    Mulac, Carolyn M.

    2012-01-01

    The all-in-one "Reference reference" you've been waiting for, this invaluable book offers a concise introduction to reference sources and services for a variety of readers, from library staff members who are asked to work in the reference department to managers and others who wish to familiarize themselves with this important area of…

  11. American Indian Reference Book.

    ERIC Educational Resources Information Center

    1976

    Designed to aid librarians, school teachers, and others in need of American Indian references and reference sources, this compilation covers a wide variety of material which has generally been scattered throughout various individual references. Specifically, this reference book includes: (1) Location of Tribes by State; (2) Locations of Tribes by…

  12. Personal Reference in English.

    ERIC Educational Resources Information Center

    Murphy, Gregory L.

    1988-01-01

    Presents a systematic investigation of the factors underlying the choice of personal reference. Five experiments examine how native-English-speaking undergraduates of Brown University refer to a professor or student in various situations. The Rule of Polite Reference (RPR) explains how speakers choose the way they will refer to a person in a given…

  13. Statistical Reference Datasets

    National Institute of Standards and Technology Data Gateway

    Statistical Reference Datasets (Web, free access)   The Statistical Reference Datasets is also supported by the Standard Reference Data Program. The purpose of this project is to improve the accuracy of statistical software by providing reference datasets with certified computational results that enable the objective evaluation of statistical software.

  14. Live, Digital Reference.

    ERIC Educational Resources Information Center

    Kenney, Brian

    2002-01-01

    Discusses digital reference services, also known as virtual reference, chat reference, or online reference, based on a round table discussion at the 2002 American Library Association annual conference in Atlanta. Topics include numbers and marketing; sustainability; competition and models; evaluation methods; outsourcing; staffing and training;…

  15. Tank characterization reference guide

    SciTech Connect

    De Lorenzo, D.S.; DiCenso, A.T.; Hiller, D.B.; Johnson, K.W.; Rutherford, J.H.; Smith, D.J.; Simpson, B.C.

    1994-09-01

    Characterization of the Hanford Site high-level waste storage tanks supports safety issue resolution; operations and maintenance requirements; and retrieval, pretreatment, vitrification, and disposal technology development. Technical, historical, and programmatic information about the waste tanks is often scattered among many sources, if it is documented at all. This Tank Characterization Reference Guide, therefore, serves as a common location for much of the generic tank information that is otherwise contained in many documents. The report is intended to be an introduction to the issues and history surrounding the generation, storage, and management of the liquid process wastes, and a presentation of the sampling, analysis, and modeling activities that support the current waste characterization. This report should provide a basis upon which those unfamiliar with the Hanford Site tank farms can start their research.

  16. Human health screening level risk assessments of tertiary-butyl acetate (TBAC): calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations.

    PubMed

    Bus, James S; Banton, Marcy I; Faber, Willem D; Kirman, Christopher R; McGregor, Douglas B; Pourreau, Daniel B

    2015-02-01

    A screening level risk assessment has been performed for tertiary-butyl acetate (TBAC) examining its primary uses as a solvent in industrial and consumer products. Hazard quotients (HQ) were developed by merging TBAC animal toxicity and dose-response data with population-level, occupational and consumer exposure scenarios. TBAC has a low order of toxicity following subchronic inhalation exposure, and neurobehavioral changes (hyperactivity) in mice observed immediately after termination of exposure were used as conservative endpoints for derivation of acute and chronic reference concentration (RfC) values. TBAC is not genotoxic but has not been tested for carcinogenicity. However, TBAC is unlikely to be a human carcinogen in that its non-genotoxic metabolic surrogates tertiary-butanol (TBA) and methyl tertiary butyl ether (MTBE) produce only male rat α-2u-globulin-mediated kidney cancer and high-dose specific mouse thyroid tumors, both of which have little qualitative or quantitative relevance to humans. Benchmark dose (BMD)-modeling of the neurobehavioral responses yielded acute and chronic RfC values of 1.5 ppm and 0.3 ppm, respectively. After conservative modeling of general population and near-source occupational and consumer product exposure scenarios, almost all HQs were substantially less than 1. HQs exceeding 1 were limited to consumer use of automotive products and paints in a poorly ventilated garage-sized room (HQ = 313) and occupational exposures in small and large brake shops using no personal protective equipment or ventilation controls (HQs = 3.4-126.6). The screening level risk assessments confirm low human health concerns with most uses of TBAC and indicate that further data-informed refinements can address problematic health/exposure scenarios. The assessments also illustrate how tier-based risk assessments using read-across toxicity information to metabolic surrogates reduce the need for comprehensive animal testing.

  17. International reference standards in coagulation.

    PubMed

    Raut, Sanj; Hubbard, Anthony R

    2010-07-01

    Measurement of coagulation factor activity using absolute physico-chemical techniques is not possible and estimation therefore relies on comparative bioassay relative to a reference standard with a known or assigned potency. However the inherent variability of locally prepared and calibrated reference standards can give rise to poor agreement between laboratories and methods. Harmonisation of measurement between laboratories at the international level relies on the availability of a common source of calibration for local reference standards and this is provided by the World Health Organization (WHO) International Standards which define the International Unit for the analyte. This article describes the principles, practices and problems of biological standardisation and the development and use of reference standards for assays of coagulation factors, with particular emphasis on WHO International Standards for both concentrates and plasma.

  18. Best Reference Sources 2001.

    ERIC Educational Resources Information Center

    Coutts, Brian; McConnell, Tamara

    2002-01-01

    Presents an annotated list of the best reference materials published in 2001. Discusses activity in the reference publishing industry; costs; and lists print materials, Web sites, databases, and CD-ROMs. (LRW)

  19. Genetics Home Reference

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues Genetics Home Reference Past Issues / Spring 2007 Table of ... of this page please turn Javascript on. The Genetics Home Reference (GHR) Web site — ghr.nlm.nih. ...

  20. Application of the hybrid approach to the benchmark dose of urinary cadmium as the reference level for renal effects in cadmium polluted and non-polluted areas in Japan

    SciTech Connect

    Suwazono, Yasushi; Nogawa, Kazuhiro; Uetani, Mirei; Nakada, Satoru; Kido, Teruhiko; Nakagawa, Hideaki

    2011-02-15

    Objectives: The aim of this study was to evaluate the reference level of urinary cadmium (Cd) that caused renal effects. An updated hybrid approach was used to estimate the benchmark doses (BMDs) and their 95% lower confidence limits (BMDL) in subjects with a wide range of exposure to Cd. Methods: The total number of subjects was 1509 (650 men and 859 women) in non-polluted areas and 3103 (1397 men and 1706 women) in the environmentally exposed Kakehashi river basin. We measured urinary cadmium (U-Cd) as a marker of long-term exposure, and {beta}2-microglobulin ({beta}2-MG) as a marker of renal effects. The BMD and BMDL that corresponded to an additional risk (BMR) of 5% were calculated with background risk at zero exposure set at 5%. Results: The U-Cd BMDL for {beta}2-MG was 3.5 {mu}g/g creatinine in men and 3.7 {mu}g/g creatinine in women. Conclusions: The BMDL values for a wide range of U-Cd were generally within the range of values measured in non-polluted areas in Japan. This indicated that the hybrid approach is a robust method for different ranges of cadmium exposure. The present results may contribute further to recent discussions on health risk assessment of Cd exposure.

  1. Academic Library Reference Services.

    ERIC Educational Resources Information Center

    Batt, Fred

    This examination of the philosophy and objectives of academic library reference services provides an overview of the major reference approaches to fulfilling the following primary objectives of reference services: (1) providing accurate answers to patrons' questions and/or helping patrons find sources to pursue their research needs; (2) building…

  2. Accurate Optical Reference Catalogs

    NASA Astrophysics Data System (ADS)

    Zacharias, N.

    2006-08-01

    Current and near future all-sky astrometric catalogs on the ICRF are reviewed with the emphasis on reference star data at optical wavelengths for user applications. The standard error of a Hipparcos Catalogue star position is now about 15 mas per coordinate. For the Tycho-2 data it is typically 20 to 100 mas, depending on magnitude. The USNO CCD Astrograph Catalog (UCAC) observing program was completed in 2004 and reductions toward the final UCAC3 release are in progress. This all-sky reference catalogue will have positional errors of 15 to 70 mas for stars in the 10 to 16 mag range, with a high degree of completeness. Proper motions for the about 60 million UCAC stars will be derived by combining UCAC astrometry with available early epoch data, including yet unpublished scans of the complete set of AGK2, Hamburg Zone astrograph and USNO Black Birch programs. Accurate positional and proper motion data are combined in the Naval Observatory Merged Astrometric Dataset (NOMAD) which includes Hipparcos, Tycho-2, UCAC2, USNO-B1, NPM+SPM plate scan data for astrometry, and is supplemented by multi-band optical photometry as well as 2MASS near infrared photometry. The Milli-Arcsecond Pathfinder Survey (MAPS) mission is currently being planned at USNO. This is a micro-satellite to obtain 1 mas positions, parallaxes, and 1 mas/yr proper motions for all bright stars down to about 15th magnitude. This program will be supplemented by a ground-based program to reach 18th magnitude on the 5 mas level.

  3. The effect of positive thinking training on the level of spiritual well-being among the patients with coronary artery diseases referred to Imam Reza specialty and subspecialty clinic in Shiraz, Iran: A randomized controlled clinical trial

    PubMed Central

    Ghodsbin, Fariba; Safaei, Marzieh; Jahanbin, Iran; Ostovan, Mohammad Ali; Keshvarzi, Sareh

    2015-01-01

    BACKGROUND Positive thinking which is derived from an optimistic view toward the universe and plays an important role in the incidence of better and a more targeted behavior among human beings. It can improve spiritual health in the individuals through increased communication with God and thanksgiving and accelerate the healing process. Accordingly, we aimed to evaluate the effect of positive thinking on the level of spiritual health in the patients with coronary artery disease (CAD) referred to Imam Reza specialty and subspecialty clinic in Shiraz, Iran. METHODS In this study randomized controlled clinical trial, we enrolled 90 patients with confirmed CAD referred to Imam Reza clinic, Shiraz, during April to July 2013. A blocking randomization method was used to randomize the final 90 participants into intervention (n = 45) and control groups (n = 45). After obtaining written informed consent, the participants were asked to complete two questionnaires. Data were collected using Ellison and Paloutzian’s spiritual well-being scale (SWBS) and a demographic questionnaire. The patients in the intervention group participated in 7 training sessions on positive thinking in which several topics were discussed. The SWBS questionnaire was completed two more times by the participants; once immediately after, and once 1 month after the intervention. 16 patients were excluded from the study due to different reasons, and finally the analysis was performed on 74 patients. RESULTS The mean ± standard deviation (SD) of spiritual well-being (SWB) increased from 88.71 ± 12.5 to 96.63 ± 12.58 in the intervention group; while, it decreased from 93.19 ± 17.55 to 94.45 ± 16.01 in the control group in the interval of before and 1 month after the intervention. We observed a statistically significant difference between the two groups regarding both variables of time and group (P < 0.001). CONCLUSION SWB is an important factor which should be considered in the treatment process, and

  4. Quality specifications for reference methods.

    PubMed

    Thienpont, L M

    1999-11-01

    Reference methods are a key element to the objective of traceability in laboratory medicine. However, to serve this purpose adequately, minimum analytical quality specifications are required. Here, possible strategies for deriving such specifications are presented, being based on concepts developed before by a European Working Group. Distinction is made between "genuine requirements" for reference methods (direct calibration with primary reference materials; absence of sample-related effects) and "performance specifications" (limits for random, systematic and total error, the latter in association with the number of measurements). While the former requirements are considered as conditio sine-qua-non, the latter specifications should be variable, which means that they should be tailored to the specific application of the methods. In general, it is advocated to derive performance specifications for reference methods from desirable specifications of routine methods (analyte-related), although other models should not be ruled out beforehand. Further, it is recommended that reference laboratories make special efforts to demonstrate and maintain a uniform level of quality of reference methods.

  5. Current density in a model of a human body with a conductive implant exposed to ELF electric and magnetic fields.

    PubMed

    Valic, Blaz; Gajsek, Peter; Miklavcic, Damijan

    2009-10-01

    A numerical model of a human body with an intramedullary nail in the femur was built to evaluate the effects of the implant on the current density distribution in extremely low frequency electric and magnetic fields. The intramedullary nail was chosen because it is one of the longest high conductive implants used in the human body. As such it is expected to alter the electric and magnetic fields significantly. The exposure was a simultaneous combination of inferior to superior electric field and posterior to anterior magnetic field both alternating at 50 Hz with the values corresponding to the ICNIRP reference levels: 5000 V m(-1) for electric field and 100 microT for magnetic flux density. The calculated current density distribution inside the model was compared to the ICNIRP basic restrictions for general public (2 mA m(-2)). The results show that the implant significantly increases the current density up to 9.5 mA m(-2) in the region where it is in contact with soft tissue in the model with the implant in comparison to 0.9 mA m(-2) in the model without the implant. As demonstrated the ICNIRP basic restrictions are exceeded in a limited volume of the tissue in spite of the compliance with the ICNIRP reference levels for general public, meaning that the existing safety limits do not necessarily protect implanted persons to the same extent as they protect people without implants.

  6. 17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas.

    PubMed

    Kiss, Agata; Delattre, Ana Márcia; Pereira, Sofia I R; Carolino, Ruither G; Szawka, Raphael E; Anselmo-Franci, Janete A; Zanata, Sílvio M; Ferraz, Anete C

    2012-02-01

    Clinical and experimental evidence suggest that estrogens have a major impact on cognition, presenting neurotrophic and neuroprotective actions in regions involved in such function. In opposite, some studies indicate that certain hormone therapy regimens may provoke detrimental effects over female cognitive and neurological function. Therefore, we decided to investigate how estrogen treatment would influence cognition and depression in different ages. For that matter, this study assessed the effects of chronic 17β-estradiol treatment over cognition and depressive-like behaviors of young (3 months old), adult (7 months old) and middle-aged (12 months old) reproductive female Wistar rats. These functions were also correlated with alterations in the serotonergic system, as well as hippocampal BDNF. 17β-Estradiol treatment did not influence animals' locomotor activity and exploratory behavior, but it was able to improve the performance of adult and middle-aged rats in the Morris water maze, the latter being more responsive to the treatment. Young and adult rats displayed decreased immobility time in the forced swimming test, suggesting an effect of 17β-estradiol also over such depressive-like behavior. This same test revealed increased swimming behavior, triggered by serotonergic pathway, in adult rats. Neurochemical evaluations indicated that 17β-estradiol treatment was able to increase serotonin turnover rate in the hippocampus of adult rats. Interestingly, estrogen treatment increased BDNF levels from animals of all ages. These findings support the notion that the beneficial effects of 17β-estradiol over spatial reference memory and depressive-like behavior are evident only when hormone therapy occurs at early ages and early stages of hormonal decline.

  7. Performance criteria for reference measurement procedures and reference materials.

    PubMed

    Schimmel, Heinz; Zegers, Ingrid

    2015-05-01

    The concept of metrological traceability of measurement results to property values assigned to measurement standards of higher metrological order or to the International System of Units (SI) through sequential calibrations, using reference materials and reference measurement procedures, plays a key role in ensuring that end user measurement procedures perform at an acceptable level in the clinical context. The aim is that measurement results produced over time or by different end users or with different end user measurement procedures for the same measurand will be equivalent within their corresponding uncertainties. These goals can only be reached under certain conditions and if requirements laid down in international standards on calibration concepts, reference measurement procedures and reference materials are fulfilled. Calibration hierarchies have to be implemented correctly and parameters contributing to measurement uncertainty and systematic bias need to be controlled and eliminated, respectively, by technically improving methods and reference materials and intermediate calibrators used for effectively achieving equivalence of measurement results and for meeting analytical performance requirements for in vitro diagnostic devices.

  8. High frequency reference electrode

    DOEpatents

    Kronberg, James W.

    1994-01-01

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or "halo" at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes.

  9. High frequency reference electrode

    DOEpatents

    Kronberg, J.W.

    1994-05-31

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or halo' at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes. 4 figs.

  10. Optical voltage reference

    DOEpatents

    Rankin, R.; Kotter, D.

    1994-04-26

    An optical voltage reference for providing an alternative to a battery source is described. The optical reference apparatus provides a temperature stable, high precision, isolated voltage reference through the use of optical isolation techniques to eliminate current and impedance coupling errors. Pulse rate frequency modulation is employed to eliminate errors in the optical transmission link while phase-lock feedback is employed to stabilize the frequency to voltage transfer function. 2 figures.

  11. Rethinking Virtual Reference

    ERIC Educational Resources Information Center

    Tenopir, Carol

    2004-01-01

    Virtual reference services seem a natural extension of libraries digital collections and the emphasis on access to the library anytime, anywhere. If patrons use the library from home, it makes sense to provide them with person-to-person online reference. The Library of Congress (LC), OCLC, and several large library systems have developed and…

  12. An Online Reference System.

    ERIC Educational Resources Information Center

    Chisman, Janet; Treat, William

    1984-01-01

    Describes a computer aid developed to assist in academic library reference service using the DataPhase Circulation System, an automated system that features full cataloging records in database and permits local programing. Access points (subject, type of reference work, course) and database structure and user screens are highlighted. (EJS)

  13. Marketing Reference Services.

    ERIC Educational Resources Information Center

    Norman, O. Gene

    1995-01-01

    Relates the marketing concept to library reference services. Highlights include a review of the literature and an overview of marketing, including research, the marketing mix, strategic plan, marketing plan, and marketing audit. Marketing principles are applied to reference services through the marketing mix elements of product, price, place, and…

  14. Ethics and Reference Services.

    ERIC Educational Resources Information Center

    Danielson, Elena S.

    1997-01-01

    While revised ethical codes provide helpful guidelines, reference archivists face many ethical questions raised by rapidly evolving technology, changing expectations, and inconsistent privacy laws that have no clear answers. Discusses issues related to reference searching, codification of ethics, cultural property and the responsibility of…

  15. China Connections Reference Book.

    ERIC Educational Resources Information Center

    Kalat, Marie B.; Hoermann, Elizabeth F.

    This reference book focuses on six aspects of the geography of the People's Republic of China. They are: territory, governing units, population and land use, waterways, land forms, and climates. Designed as a primary reference, the book explains how the Chinese people and their lifestyles are affected by China's geography. Special components…

  16. A standard satellite control reference model

    NASA Technical Reports Server (NTRS)

    Golden, Constance

    1994-01-01

    This paper describes a Satellite Control Reference Model that provides the basis for an approach to identify where standards would be beneficial in supporting space operations functions. The background and context for the development of the model and the approach are described. A process for using this reference model to trace top level interoperability directives to specific sets of engineering interface standards that must be implemented to meet these directives is discussed. Issues in developing a 'universal' reference model are also identified.

  17. Value of Information References

    DOE Data Explorer

    Morency, Christina

    2014-12-12

    This file contains a list of relevant references on value of information (VOI) in RIS format. VOI provides a quantitative analysis to evaluate the outcome of the combined technologies (seismology, hydrology, geodesy) used to monitor Brady's Geothermal Field.

  18. Enterprise Reference Library

    NASA Technical Reports Server (NTRS)

    Bickham, Grandin; Saile, Lynn; Havelka, Jacque; Fitts, Mary

    2011-01-01

    Introduction: Johnson Space Center (JSC) offers two extensive libraries that contain journals, research literature and electronic resources. Searching capabilities are available to those individuals residing onsite or through a librarian s search. Many individuals have rich collections of references, but no mechanisms to share reference libraries across researchers, projects, or directorates exist. Likewise, information regarding which references are provided to which individuals is not available, resulting in duplicate requests, redundant labor costs and associated copying fees. In addition, this tends to limit collaboration between colleagues and promotes the establishment of individual, unshared silos of information The Integrated Medical Model (IMM) team has utilized a centralized reference management tool during the development, test, and operational phases of this project. The Enterprise Reference Library project expands the capabilities developed for IMM to address the above issues and enhance collaboration across JSC. Method: After significant market analysis for a multi-user reference management tool, no available commercial tool was found to meet this need, so a software program was built around a commercial tool, Reference Manager 12 by The Thomson Corporation. A use case approach guided the requirements development phase. The premise of the design is that individuals use their own reference management software and export to SharePoint when their library is incorporated into the Enterprise Reference Library. This results in a searchable user-specific library application. An accompanying share folder will warehouse the electronic full-text articles, which allows the global user community to access full -text articles. Discussion: An enterprise reference library solution can provide a multidisciplinary collection of full text articles. This approach improves efficiency in obtaining and storing reference material while greatly reducing labor, purchasing and

  19. Reach for Reference. Grolier's The Civil War

    ERIC Educational Resources Information Center

    Safford, Barbara Ripp

    2005-01-01

    This column describes Grolier's new ten-volume reference set, "The Civil War." The volumes are easy to handle and the set's appearance is designed to appeal to middle level students. Arrangement is alphabetical from Abolition in volume one to Zouaves in volume ten with reasonable cross references to other relevant articles. Each volume contains a…

  20. Precision displacement reference system

    DOEpatents

    Bieg, Lothar F.; Dubois, Robert R.; Strother, Jerry D.

    2000-02-22

    A precision displacement reference system is described, which enables real time accountability over the applied displacement feedback system to precision machine tools, positioning mechanisms, motion devices, and related operations. As independent measurements of tool location is taken by a displacement feedback system, a rotating reference disk compares feedback counts with performed motion. These measurements are compared to characterize and analyze real time mechanical and control performance during operation.

  1. Membrane reference electrode

    DOEpatents

    Redey, L.; Bloom, I.D.

    1988-01-21

    A reference electrode utilizes a small thin, flat membrane of a highly conductive glass placed on a small diameter insulator tube having a reference material inside in contact with an internal voltage lead. When the sensor is placed in a non-aqueous ionic electrolytic solution, the concentration difference across the glass membrane generates a low voltage signal in precise relationship to the concentration of the species to be measured, with high spatial resolution. 2 figs.

  2. USGS reference materials

    USGS Publications Warehouse

    ,

    1995-01-01

    Every year in the United States, millions of measurements are made on the chemical composition of items that affect us on a daily basis. Determining the accuracy of these measurements is based on the analysis of appropriate reference materials whose composition was previously determined through rigorous testing. Today, reference materials help us evaluate the composition of the food we eat, medicine we use, soil we grow our crops in, and hundreds of other products that affect our everyday lives.

  3. Reference Man anatomical model

    SciTech Connect

    Cristy, M.

    1994-10-01

    The 70-kg Standard Man or Reference Man has been used in physiological models since at least the 1920s to represent adult males. It came into use in radiation protection in the late 1940s and was developed extensively during the 1950s and used by the International Commission on Radiological Protection (ICRP) in its Publication 2 in 1959. The current Reference Man for Purposes of Radiation Protection is a monumental book published in 1975 by the ICRP as ICRP Publication 23. It has a wealth of information useful for radiation dosimetry, including anatomical and physiological data, gross and elemental composition of the body and organs and tissues of the body. The anatomical data includes specified reference values for an adult male and an adult female. Other reference values are primarily for the adult male. The anatomical data include much data on fetuses and children, although reference values are not established. There is an ICRP task group currently working on revising selected parts of the Reference Man document.

  4. Caseview: building the reference set.

    PubMed

    Lévy, Pierre P

    2004-01-01

    There is a worldwide consensus for using the diagnosis related groups (DRG) when considering hospital activity. This tool leads to the production of tables of numbers (case mix), the interpretation of which is difficult. Therefore, methods aimed at facilitating this interpretation are needed. One of such methods is the case view, i.e. a graphical representation of the case mix. It reduces, in a way, each DRG to a "pixel", the set of the DRGs being an image (the case view). The reference set should be organized according to three criteria: medical/surgical, nosological and economic. This method can be used to answer theoretical questions or to visualize activity at the level of a hospital or at the level of a department. The purpose of this paper is to present important principles inherent in this graphic representation, both at the level of the method and at the level of the user.

  5. New reference values for calcium.

    PubMed

    2013-01-01

    The nutrition societies of Germany, Austria and Switzerland are the joint editors of the 'reference values for nutrient intake'. They have revised the reference values for the intake of calcium and published them in June 2013. The reference values for the calcium intake for infants are derived from the calcium content of breast milk. For infants from 4 to <12 months of age, the calcium intake from solid foods is included in addition to the calcium intake from breast milk. Thus, the reference values for infants are estimated values; they are 220 mg/day for infants to <4 months and 330 mg/day for infants from 4 to <12 months of age. As a parameter for determining the calcium requirement in children and adolescents, calcium retention is taken into account. The average requirement is calculated by the factorial method. A balanced calcium metabolism is calculated based upon calcium balance studies and used as a parameter for the determination of the calcium requirement in adults. On the basis of the average requirement, recommended calcium intake levels for children, adolescents and adults are derived. Depending on age, the recommended calcium intake ranges between 600 mg/day for children aged 1 to <4 years and 1,200 mg/day for adolescents aged 13 to <19 years; for adults, it is 1,000 mg/day. PMID:24356454

  6. Microgrid cyber security reference architecture.

    SciTech Connect

    Veitch, Cynthia K.; Henry, Jordan M.; Richardson, Bryan T.; Hart, Derek H.

    2013-07-01

    This document describes a microgrid cyber security reference architecture. First, we present a high-level concept of operations for a microgrid, including operational modes, necessary power actors, and the communication protocols typically employed. We then describe our motivation for designing a secure microgrid; in particular, we provide general network and industrial control system (ICS)-speci c vulnerabilities, a threat model, information assurance compliance concerns, and design criteria for a microgrid control system network. Our design approach addresses these concerns by segmenting the microgrid control system network into enclaves, grouping enclaves into functional domains, and describing actor communication using data exchange attributes. We describe cyber actors that can help mitigate potential vulnerabilities, in addition to performance bene ts and vulnerability mitigation that may be realized using this reference architecture. To illustrate our design approach, we present a notional a microgrid control system network implementation, including types of communica- tion occurring on that network, example data exchange attributes for actors in the network, an example of how the network can be segmented to create enclaves and functional domains, and how cyber actors can be used to enforce network segmentation and provide the neces- sary level of security. Finally, we describe areas of focus for the further development of the reference architecture.

  7. Setting reference targets

    SciTech Connect

    Ruland, R.E.

    1997-04-01

    Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets.

  8. Multifunctional reference electrode

    DOEpatents

    Redey, Laszlo; Vissers, Donald R.

    1983-01-01

    A multifunctional, low mass reference electrode of a nickel tube, thermocouple means inside the nickel tube electrically insulated therefrom for measuring the temperature thereof, a housing surrounding the nickel tube, an electrolyte having a fixed sulfide ion activity between the housing and the outer surface of the nickel tube forming the nickel/nickel sulfide/sulfide half-cell. An ion diffusion barrier is associated with the housing in contact with the electrolyte. Also disclosed is a cell using the reference electrode to measure characteristics of a working electrode.

  9. Multifunctional reference electrode

    DOEpatents

    Redey, L.; Vissers, D.R.

    1981-12-30

    A multifunctional, low mass reference electrode of a nickel tube, thermocouple means inside the nickel tube electrically insulated therefrom for measuring the temperature thereof, a housing surrounding the nickel tube, an electrolyte having a fixed sulfide ion activity between the housing and the outer surface of the nickel tube forming the nickel/nickel sulfide/sulfide half-cell are described. An ion diffusion barrier is associated with the housing in contact with the electrolyte. Also disclosed is a cell using the reference electrode to measure characteristics of a working electrode.

  10. Aluminum reference electrode

    DOEpatents

    Sadoway, Donald R.

    1988-01-01

    A stable reference electrode for use in monitoring and controlling the process of electrolytic reduction of a metal. In the case of Hall cell reduction of aluminum, the reference electrode comprises a pool of molten aluminum and a solution of molten cryolite, Na.sub.3 AlF.sub.6, wherein the electrical connection to the molten aluminum does not contact the highly corrosive molten salt solution. This is accomplished by altering the density of either the aluminum (decreasing the density) or the electrolyte (increasing the density) so that the aluminum floats on top of the molten salt solution.

  11. Aluminum reference electrode

    DOEpatents

    Sadoway, D.R.

    1988-08-16

    A stable reference electrode is described for use in monitoring and controlling the process of electrolytic reduction of a metal. In the case of Hall cell reduction of aluminum, the reference electrode comprises a pool of molten aluminum and a solution of molten cryolite, Na[sub 3]AlF[sub 6], wherein the electrical connection to the molten aluminum does not contact the highly corrosive molten salt solution. This is accomplished by altering the density of either the aluminum (decreasing the density) or the electrolyte (increasing the density) so that the aluminum floats on top of the molten salt solution. 1 fig.

  12. NASCAP programmer's reference manual

    NASA Technical Reports Server (NTRS)

    Mandell, M. J.; Stannard, P. R.; Katz, I.

    1993-01-01

    The NASA Charging Analyzer Program (NASCAP) is a computer program designed to model the electrostatic charging of complicated three-dimensional objects, both in a test tank and at geosynchronous altitudes. This document is a programmer's reference manual and user's guide. It is designed as a reference to experienced users of the code, as well as an introduction to its use for beginners. All of the many capabilities of NASCAP are covered in detail, together with examples of their use. These include the definition of objects, plasma environments, potential calculations, particle emission and detection simulations, and charging analysis.

  13. Isotope reference materials

    USGS Publications Warehouse

    Coplen, Tyler B.

    2010-01-01

    Measurement of the same isotopically homogeneous sample by any laboratory worldwide should yield the same isotopic composition within analytical uncertainty. International distribution of light element isotopic reference materials by the International Atomic Energy Agency and the U.S. National Institute of Standards and Technology enable laboratories to achieve this goal.

  14. Generating Multimodal References

    ERIC Educational Resources Information Center

    van der Sluis, Ielka; Krahmer, Emiel

    2007-01-01

    This article presents a new computational model for the generation of multimodal referring expressions (REs), based on observations in human communication. The algorithm is an extension of the graph-based algorithm proposed by Krahmer, van Erk, and Verleg (2003) and makes use of a so-called Flashlight Model for pointing. The Flashlight Model…

  15. Dietary Reference Intakes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Dietary Reference Intakes (DRI) are recommendations intended to provide a framework for nutrient intake evaluation, as well as meal planning on the basis of nutrient adequacy. They are nutrient, not food based recommendations, created with chronic disease risk reduction as the primary goal, as ...

  16. Role and Reference Grammar.

    ERIC Educational Resources Information Center

    Van Valin, Robert D., Jr.

    This paper discusses Role and Reference Grammar (RRG), which is a structuralist-formalist theory of grammar. RRG grew out of an attempt to answer two fundamental questions: (1) what would linguistic theory look like if it were based on the analysis of Lakhota, Tagalog, and Dyirbal, rather than on the analysis of English?; and (2) how can the…

  17. Volunteeer's Reference Guide.

    ERIC Educational Resources Information Center

    Armstrong, Julie; And Others

    For Postpartum Education for Parents (PEP) volunteers, this reference guide provides background information about the common concerns of parents. Extensively reviewed for accuracy and content by pediatricians, psychologists, obstetricians, nurses, and childbirth educators, the guide contains a summary discussion of the postpartum infant and…

  18. The Reference Encounter Model.

    ERIC Educational Resources Information Center

    White, Marilyn Domas

    1983-01-01

    Develops model of the reference interview which explicitly incorporates human information processing, particularly schema ideas presented by Marvin Minsky and other theorists in cognitive processing and artificial intelligence. Questions are raised concerning use of content analysis of transcribed verbal protocols as methodology for studying…

  19. Hospitality Services Reference Book.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This reference book provides information needed by employees in hospitality services occupations. It includes 29 chapters that cover the following topics: the hospitality services industry; professional ethics; organization and management structures; safety practices and emergency procedures; technology; property maintenance and repair; purchasing…

  20. Reference Collections and Standards.

    ERIC Educational Resources Information Center

    Winkel, Lois

    1999-01-01

    Reviews six reference materials for young people: "The New York Public Library Kid's Guide to Research"; "National Audubon Society First Field Guide. Mammals"; "Star Wars: The Visual Dictionary"; "Encarta Africana"; "World Fact Book, 1998"; and "Factastic Book of 1001 Lists". Includes ordering information.(AEF)

  1. The Unreliability of References

    ERIC Educational Resources Information Center

    Barden, Dennis M.

    2008-01-01

    When search consultants, like the author, are invited to propose their services in support of a college or university seeking new leadership, they are generally asked a fairly standard set of questions. But there is one question that they find among the most difficult to answer: How do they check a candidate's references to ensure that they know…

  2. A GUJARATI REFERENCE GRAMMAR.

    ERIC Educational Resources Information Center

    CARDONA, GEORGE

    THIS REFERENCE GRAMMAR WAS WRITTEN TO FILL THE NEED FOR AN UP-TO-DATE ANALYSIS OF THE MODERN LANGUAGE SUITABLE FOR LANGUAGE LEARNERS AS WELL AS LINGUISTS. THE AUTHOR LISTS IN THE INTRODUCTION THOSE STUDIES PREVIOUS TO THIS ONE WHICH MAY BE OF INTEREST TO THE READER. INCLUDED IN HIS ANALYSIS OF THE LANGUAGE ARE MAJOR CHAPTERS ON--(1) PHONOLOGY, (2)…

  3. Reference Book Guides.

    ERIC Educational Resources Information Center

    Webb, Bill, Ed.

    For each reference work there is a 5 1/2 x 8 1/2" card with information about the work in brief, standardized format. The card indicates what the subject coverage is, the types of materials included, the service given, frequency of publication, procedure for use, an example of the procedure, a sample entry with explanatory notes, other places to…

  4. Reference-Dependent Sympathy

    ERIC Educational Resources Information Center

    Small, Deborah A.

    2010-01-01

    Natural disasters and other traumatic events often draw a greater charitable response than do ongoing misfortunes, even those that may cause even more widespread misery, such as famine or malaria. Why is the response disproportionate to need? The notion of reference dependence critical to Prospect Theory (Kahneman & Tversky, 1979) maintains that…

  5. Reflections on Reference Services.

    ERIC Educational Resources Information Center

    Brandt, Kerryn A.; And Others

    1996-01-01

    Describes programmatic changes in reference services at the Johns Hopkins University (Maryland) medical library and speculates on the future. Topics include institutional restructuring and consolidation; improvements in technology infrastructure; external economic pressure; and fiscal accountability, including library funding and cost center…

  6. Chat Reference. SPEC Kit.

    ERIC Educational Resources Information Center

    Ronan, Jana, Comp.; Turner, Carol, Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to gather data on chat reference service. A total of 66 of 124 ARL member libraries responded to the survey. A copy of the questionnaire with tabulated results is presented. Representative…

  7. International reference ionosphere 1990

    NASA Technical Reports Server (NTRS)

    Bilitza, Dieter; Rawer, K.; Bossy, L.; Kutiev, I.; Oyama, K.-I.; Leitinger, R.; Kazimirovsky, E.

    1990-01-01

    The International Reference Ionosphere 1990 (IRI-90) is described. IRI described monthly averages of the electron density, electron temperature, ion temperature, and ion composition in the altitude range from 50 to 1000 km for magnetically quiet conditions in the non-auroral ionosphere. The most important improvements and new developments are summarized.

  8. THAI, REFERENCE GRAMMAR.

    ERIC Educational Resources Information Center

    NOSS, RICHARD B.

    A REFERENCE GRAMMAR FOR THE THAI LANGUAGE IS PROVIDED. THE MAIN STRUCTURAL FEATURES OF STANDARD SPOKEN THAI ARE OUTLINED AND ELABORATED BY SUBCLASSIFICATION AND EXAMPLE. IN ADDITION, AN INDEX OF MINOR FORM-CLASS MEMBERS IS PROVIDED. THE APPROACH TO CLASSIFICATION OF GRAMMATICAL FEATURES FOLLOWS CURRENT TECHNIQUES OF AMERICAN DESCRIPTIVE…

  9. Multimedia Reference Tools.

    ERIC Educational Resources Information Center

    Holzberg, Carol S.

    2001-01-01

    Presents suggestions for content-rich classroom encyclopedias on CO-ROM and DVD, including: the Encarta Reference Suite 2001; the 2001 Grolier Multimedia Encyclopedia, School Edition; the Britannica 2001 DVD; and the World Book 2001 Deluxe Edition, v5.0. (SM)

  10. Reference Model Development

    SciTech Connect

    Jepsen, Richard

    2011-11-02

    Presentation from the 2011 Water Peer Review in which principal investigator discusses project progress to develop a representative set of Reference Models (RM) for the MHK industry to develop baseline cost of energy (COE) and evaluate key cost component/system reduction pathways.

  11. Selecting a Reference Object

    ERIC Educational Resources Information Center

    Miller, Jared E.; Carlson, Laura A.; Hill, Patrick L.

    2011-01-01

    One way to describe the location of an object is to relate it to another object. Often there are many nearby objects, each of which could serve as a candidate to be the reference object. A common theoretical assumption is that features that make a given object salient relative to the candidate set are instrumental in determining which is selected.…

  12. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?

    PubMed

    Golparian, Daniel; Fernandes, Prabhavathi; Ohnishi, Makoto; Jensen, Jörgen S; Unemo, Magnus

    2012-05-01

    Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.

  13. Reference materials for new psychoactive substances.

    PubMed

    Archer, Roland P; Treble, Ric; Williams, Keith

    2011-01-01

    Historically, the appearance of new psychoactive materials (and hence the requirement for new reference standards) has been relatively slow. This position has now changed, with 101 new psychoactive substances reported to EMCDDA-Europol since 2006. The newly reported materials, and associated metabolites, require properly certified reference materials to permit reliable identification and quantification. The traditional approach and timescales of reference material production and certification are being increasingly challenged by the appearance of these new substances. Reference material suppliers have to adopt new strategies to meet the needs of laboratories. This situation is particularly challenging for toxicology standards as the metabolism of many of these substances is initially unknown. Reference material production often involves synthesis from first principles. While it is possible to synthesis these materials, there can be significant difficulties, from synthetic complexities through to the need to use controlled materials. These issues are examined through a discussion of the synthesis of cathinones. Use of alternative sources, including pharmaceutical impurity materials or internet sourced products, as starting materials for conversion into appropriately certified reference materials are also discussed. The sudden appearance and sometimes brief lifetime in the market place of many of these novel legal highs or research chemicals present commercial difficulties for reference material producers. The need for collaboration at all levels is highlighted as essential to rapid identification of requirements for new reference materials. National or international commissioning or support may also be required to permit reference material producers to recover their development costs. PMID:21744516

  14. Science Reference Materials for Children and Young Adults

    ERIC Educational Resources Information Center

    Strickler, Richard L.

    1974-01-01

    After a brief discussion of science reference service, there is a list of science reference books. First are general science books, then specific lists by broad Dewey decimal classes. Grade levels are given for each work. (LS)

  15. OSH technical reference manual

    SciTech Connect

    Not Available

    1993-11-01

    In an evaluation of the Department of Energy (DOE) Occupational Safety and Health programs for government-owned contractor-operated (GOCO) activities, the Department of Labor`s Occupational Safety and Health Administration (OSHA) recommended a technical information exchange program. The intent was to share written safety and health programs, plans, training manuals, and materials within the entire DOE community. The OSH Technical Reference (OTR) helps support the secretary`s response to the OSHA finding by providing a one-stop resource and referral for technical information that relates to safe operations and practice. It also serves as a technical information exchange tool to reference DOE-wide materials pertinent to specific safety topics and, with some modification, as a training aid. The OTR bridges the gap between general safety documents and very specific requirements documents. It is tailored to the DOE community and incorporates DOE field experience.

  16. The NPL reference hazemeter

    NASA Astrophysics Data System (ADS)

    Freeman, G. H. C.

    1992-09-01

    The reference hazemeter is a development of a commercial pivotable sphere hazemeter. The principle improvements are a high quality photometer and its associated electronic and temperature controller, a stable power supply for the source and the determination of the lamp current of illuminants A and C, improvements to the optics to achieve a well shaped beam, and mechanical modifications to accommodate the improvements and allow a good mechanical movement. Various tests were carried out to validate the instrument behavior. These identified systematic errors caused by inter-reflections. To reduce the inter-reflection errors, the blue filter and the input lenses were antireflection coated. The reference hazemeter complies with BS 2782--methods of testing plastics; part 5--optical and color properties; method 521A--determination of haze of film and sheet. A calibration service using the hazemeter is now in operation.

  17. The Brewer reference triad

    NASA Astrophysics Data System (ADS)

    Fioletov, V. E.; Kerr, J. B.; McElroy, C. T.; Wardle, D. I.; Savastiouk, V.; Grajnar, T. S.

    2005-10-01

    It has been more than 20 years since the Brewer reference triad was established by Environment Canada at Toronto. The triad serves as a reference for traveling standard instruments that are used to calibrate Brewer spectrophotometers around the world. The members of the triad are calibrated on a regular basis at Mauna Loa, Hawaii. Regular tests made with an internal quartz halogen lamp make it possible to track the instrument response between the calibrations. A new analysis of available column ozone data records indicates that the uncertainty in the daily values derived from each instrument is approximately 0.6%. The random errors of individual observations are within +/-1% for 90% of all measurements. Sources of potential errors in the individual Brewer measurements as well as quality control tools are also discussed.

  18. Alignment reference device

    DOEpatents

    Patton, Gail Y.; Torgerson, Darrel D.

    1987-01-01

    An alignment reference device provides a collimated laser beam that minimizes angular deviations therein. A laser beam source outputs the beam into a single mode optical fiber. The output end of the optical fiber acts as a source of radiant energy and is positioned at the focal point of a lens system where the focal point is positioned within the lens. The output beam reflects off a mirror back to the lens that produces a collimated beam.

  19. Reference Undulator Measurement Results

    SciTech Connect

    Wolf, Zachary; Levashov, Yurii; /SLAC

    2011-08-18

    The LCLS reference undulator has been measured 22 times during the course of undulator tuning. These measurements provide estimates of various statistical errors. This note gives a summary of the reference undulator measurements and it provides estimates of the undulator tuning errors. We measured the reference undulator many times during the tuning of the LCLS undulators. These data sets give estimates of the random errors in the tuned undulators. The measured trajectories in the reference undulator are stable and straight to within {+-}2 {micro}m. Changes in the phase errors are less than {+-}2 deg between data sets. The phase advance in the cell varies by less than {+-}2 deg between data sets. The rms variation between data sets of the first integral of B{sub x} is 9.98 {micro}Tm, and the rms variation of the second integral of B{sub x} is 17.4 {micro}Tm{sup 2}. The rms variation of the first integral of B{sub y} is 6.65 {micro}Tm, and the rms variation of the second integral of B{sub y} is 12.3 {micro}Tm{sup 2}. The rms variation of the x-position of the fiducialized beam axis is 35 {micro}m in the final production run This corresponds to an rms uncertainty in the K value of {Delta}K/K = 2.7 x 10{sup -5}. The rms variation of the y-position of the fiducialized beam axis is 4 {micro}m in the final production run.

  20. [Influence of exogenous salicylic acid on the level of phytohormones in tissues of Phlox paniculata and Phlox setacea leaves with special reference to resistance against the powdery mildew causative agent Erysiphe cichoracearum D.C. f. phlogis Jacz].

    PubMed

    Talieva, M N; Kondrat'eva, V V

    2002-01-01

    We studied the effects of exogenous salicylic acid on the level of endogenous cytokinins and abscisic and salicylic acids in the tissues of leaves of phloxes contrasting in resistance against the powdery mildew causative agent: susceptible Phlox paniculata L. and resistant Ph. setacea L. Studies were carried out under the conditions of biotic stress. The initial level of salicylic and abscisic acids and cytokinins is the highest in the resistant phlox species. After treatment with salicylic species, the total level of cytokinins and endogenous salicylic acid increased in both species. When the treated phlox species were infected by the powdery mildew causative agent, the level of abscisic and salicylic acids increased in the susceptible Ph. paniculata, while that of cytokinins increased in the resistant Ph. setacea. The role of salicylic acid in the induction of plant defense reactions against phytopathogens is discussed.

  1. Celestial Reference Frames

    NASA Astrophysics Data System (ADS)

    Jacobs, Christopher S.

    2013-03-01

    Concepts and Background: This paper gives an overview of modern celestial reference frames as realized at radio frequencies using the Very Long baseline Interferometry (VLBI) technique. We discuss basic celestial reference frame concepts, desired properties, and uses. We review the networks of antennas used for this work. We briefly discuss the history of the science of astrometry touching upon the discovery of precession, proper motion, nutation, and parallax, and the field of radio astronomy. Building Celestial Frames: Next, we discuss the multi-step process of building a celestial frame: First candidate sources are identified based on point-like properties from single dish radio telescopes surveys. Second, positions are refined using connected element interferometers such as the Very Large Array, and the ATCA. Third, positions of approximately milli-arcsecond (mas) accuracy are determined using intercontinental VLBI surveys. Fourth, sub-mas positions are determined by multiyear programs using intercontinental VLBI. These sub-mas sets of positions are then verified by multiple teams in preparation for release to non-specialists in the form of an official IAU International Celestial Reference Frame (ICRF). The process described above has until recently been largely restricted to work at S/X-band (2.3/8.4 GHz). However, in the last decade sub-mas work has expanded to include celestial frames at K-band (24 GHz), Ka-band (32 GHz), and Q-band (43 GHz). While these frames currently have the disadvantage of far smaller data sets, the astrophysical quality of the sources themselves improves at these higher frequencies and thus make these frequencies attractive for realizations of celestial reference frames. Accordingly, we review progress at these higher frequency bands. Path to the Future: We discuss prospects for celestial reference frames over the next decade. We present an example of an error budget for astrometric VLBI and discuss the budget's use as a tool for

  2. Celestial Reference Frame

    NASA Astrophysics Data System (ADS)

    Jacobs, Christopher S.

    2013-09-01

    Concepts and Background: This paper gives an overview of modern celestial reference frames as realized at radio frequencies using the Very Long baseline Interferometry (VLBI) technique. We discuss basic celestial reference frame concepts, desired properties, and uses. We review the networks of antennas used for this work. We briefly discuss the history of the science of astrometry touching upon the discovery of precession, proper motion, nutation, and parallax, and the field of radio astronomy. Building Celestial Frames: Next, we discuss the multi-step process of building a celestial frame: First candidate sources are identified based on point-like properties from single dish radio telescopes surveys. Second, positions are refined using connected element interferometers such as the Very Large Array, and the ATCA. Third, positions of approximately milli-arcsecond (mas) accuracy are determined using intercontinental VLBI surveys. Fourth, sub-mas positions are determined by multiyear programs using intercontinental VLBI. These sub-mas sets of positions are then verified by multiple teams in preparation for release to non-specialists in the form of an official IAU International Celestial Reference Frame (ICRF). The process described above has until recently been largely restricted to work at S/X-band (2.3/8.4 GHz). However, in the last decade sub-mas work has expanded to include celestial frames at K-band (24 GHz), Ka-band (32 GHz), and Q-band (43 GHz). While these frames currently have the disadvantage of far smaller data sets, the astrophysical quality of the sources themselves improves at these higher frequencies and thus make these frequencies attractive for realizations of celestial reference frames. Accordingly, we review progress at these higher frequency bands. Path to the Future: We discuss prospects for celestial reference frames over the next decade. We present an example of an error budget for astrometric VLBI and discuss the budget's use as a tool for

  3. MSDS sky reference and preamplifier study

    NASA Technical Reports Server (NTRS)

    Larsen, L.; Stewart, S.; Lambeck, P.

    1974-01-01

    The major goals in re-designing the Multispectral Scanner and Data System (MSDS) sky reference are: (1) to remove the sun-elevation angle and aircraft-attitude angle dependence from the solar-sky illumination measurement, and (2) to obtain data on the optical state of the atmosphere. The present sky reference is dependent on solar elevation and provides essentially no information on important atmospheric parameters. Two sky reference designs were tested. One system is built around a hyperbolic mirror and the reflection approach. A second approach to a sky reference utilizes a fish-eye lens to obtain a 180 deg field of view. A detailed re-design of the present sky reference around the fish-eye approach, even with its limitations, is recommended for the MSDS system. A preamplifier study was undertaken to find ways of improving the noise-equivalent reflectance by reducing the noise level for silicon detector channels on the MSDS.

  4. Urinary {alpha}{sub 1}-microglobulin, {beta}{sub 2}-microglobulin, and retinol-binding protein levels in general populations in Japan with references to cadmium in urine, blood, and 24-hour food duplicates

    SciTech Connect

    Ikeda, Masayuki; Moon, Chan-Seok; Zhang, Zuo-Wen

    1995-07-01

    Possible cadmium (Cd) exposure-associated changes in urinary levels of low-molecular-weight proteins were studied in nonsmoking and nondrinking female members of the general Japanese population (378 subjects with no known occupational heavy metal exposure) who lived at 19 study sites (all without any known environmental heavy metal pollution) in 13 prefectures throughout Japan. The external Cd dose was evaluated in terms of daily Cd intake via food (Cd-F), whereas Cd levels in blood (Cd-B) and urine (Cd-U) were taken as internal dose indicators. When the subjects were classified according to Cd-F into three groups with {open_quotes}low{close_quotes} (20.4 {mu}g/day as a geometric mean of 97 women), {open_quotes}middle{close_quotes} (35.0 {mu}g/day, 120 women) and {open_quotes}high{close_quotes} (67.0 {mu}g/day, 66 women) exposure, both Cd-B and Cd-U increased in parallel with the changes in Cd-F. However, there were no dose-dependent changes in {beta}{sub 2}-microglobulin or retinol-binding protein levels in urine. {alpha}{sub 1}-Microglobulin levels appeared to increase, but the distribution of the cases above the two cutoff levels of 9.6 and 15.8 {mu}g/mg creatinine among the three Cd-F groups did not show any bias. Overall, it was concluded that there was no apparent Cd exposure-associated elevation in urinary low-molecular-weight protein levels in the study population. 41 refs., 2 figs., 7 tabs.

  5. Reference Inflow Characterization for River Resource Reference Model (RM2)

    SciTech Connect

    Neary, Vincent S

    2011-12-01

    Sandia National Laboratory (SNL) is leading an effort to develop reference models for marine and hydrokinetic technologies and wave and current energy resources. This effort will allow the refinement of technology design tools, accurate estimates of a baseline levelized cost of energy (LCoE), and the identification of the main cost drivers that need to be addressed to achieve a competitive LCoE. As part of this effort, Oak Ridge National Laboratory was charged with examining and reporting reference river inflow characteristics for reference model 2 (RM2). Published turbulent flow data from large rivers, a water supply canal and laboratory flumes, are reviewed to determine the range of velocities, turbulence intensities and turbulent stresses acting on hydrokinetic technologies, and also to evaluate the validity of classical models that describe the depth variation of the time-mean velocity and turbulent normal Reynolds stresses. The classical models are found to generally perform well in describing river inflow characteristics. A potential challenge in river inflow characterization, however, is the high variability of depth and flow over the design life of a hydrokinetic device. This variation can have significant effects on the inflow mean velocity and turbulence intensity experienced by stationary and bottom mounted hydrokinetic energy conversion devices, which requires further investigation, but are expected to have minimal effects on surface mounted devices like the vertical axis turbine device designed for RM2. A simple methodology for obtaining an approximate inflow characterization for surface deployed devices is developed using the relation umax=(7/6)V where V is the bulk velocity and umax is assumed to be the near-surface velocity. The application of this expression is recommended for deriving the local inflow velocity acting on the energy extraction planes of the RM2 vertical axis rotors, where V=Q/A can be calculated given a USGS gage flow time

  6. Dietary reference intervals for vitamin D.

    PubMed

    Cashman, Kevin D

    2012-01-01

    Dietary reference intervals relate to the distribution of dietary requirement for a particular nutrient as defined by the distribution of physiological requirement for that nutrient. These have more commonly been called Dietary Reference Values (DRV) or Dietary Reference Intakes (DRI), amongst other names. The North American DRI for vitamin D are the most current dietary reference intervals and arguably arising from the most comprehensive evaluation and report on vitamin D nutrition to date. These are a family of nutrient reference values, including the Estimated Average Requirement (EAR), the Recommended Dietary Allowance (RDA), the Adequate Intake, and Tolerable Upper Intake Level. In particular, the EAR is used for planning and assessing diets of populations; it also serves as the basis for calculating the RDA, a value intended to meet the needs of nearly all people. The DRVs for vitamin D in the UK and the European Community have been in existence for almost two decades, and both are currently under review. The present paper briefly overviews these three sets of dietary reference intervals as case studies to highlight both the similarities as well as possible differences that may exist between reference intervals for vitamin D in different countries/regions. In addition, it highlights the scientific basis upon which these are based, which may explain some of the differences. Finally, it also overviews how the dietary reference intervals for vitamin D may be applied, and especially in terms of assessing the adequacy of vitamin D intake in populations. PMID:22536775

  7. Antares Reference Telescope System

    SciTech Connect

    Viswanathan, V.K.; Kaprelian, E.; Swann, T.; Parker, J.; Wolfe, P.; Woodfin, G.; Knight, D.

    1983-01-01

    Antares is a 24-beam, 40-TW carbon-dioxide laser-fusion system currently nearing completion at the Los Alamos National Laboratory. The 24 beams will be focused onto a tiny target (typically 300 to 1000 ..mu..m in diameter) located approximately at the center of a 7.3-m-diameter by 9.3-m-long vacuum (10/sup -6/ torr) chamber. The design goal is to position the targets to within 10 ..mu..m of a selected nominal position, which may be anywhere within a fixed spherical region 1 cm in diameter. The Antares Reference Telescope System is intended to help achieve this goal for alignment and viewing of the various targets used in the laser system. The Antares Reference Telescope System consists of two similar electro-optical systems positioned in a near orthogonal manner in the target chamber area of the laser. Each of these consists of four subsystems: (1) a fixed 9X optical imaging subsystem which produces an image of the target at the vidicon; (2) a reticle projection subsystem which superimposes an image of the reticle pattern at the vidicon; (3) an adjustable front-lighting subsystem which illuminates the target; and (4) an adjustable back-lighting subsystem which also can be used to illuminate the target. The various optical, mechanical, and vidicon design considerations and trade-offs are discussed. The final system chosen (which is being built) and its current status are described in detail.

  8. Antares reference telescope system

    NASA Astrophysics Data System (ADS)

    Viswanathan, V. K.; Kaprelian, E.; Swann, T.; Parker, J.; Wolfe, P.; Woodfin, G.; Knight, D.

    Antares is a 24 beam, 40 TW carbon dioxide laser fusion system currently nearing completion. The 24 beams will be focused onto a tiny target. It is to position the targets to within 10 (SIGMA)m of a selected nominal position, which may be anywhere within a fixed spherical region 1 cm in diameter. The Antares reference telescope system is intended to help achieve this goal for alignment and viewing of the various targets used in the laser system. The Antares reference telescope system consists of two similar electrooptical systems positioned in a near orthogonal manner in the target chamber area of the laser. Each of these consists of four subsystems: (1) a fixed 9% optical imaging subsystem which produces an image of the target at the vidicon; (2) a reticle projection subsystem which superimposes an image of the reticle pattern at the vidicon; (3) an adjustable front lighting subsystem which illuminates the target; and (4) an adjustable back lighting subsystem which also can be used to illuminate the target. The various optical, mechanical, and vidicon design considerations and tradeoffs are discussed. The final system chosen and its current status are described.

  9. Coal data: A reference

    SciTech Connect

    Not Available

    1995-02-01

    This report, Coal Data: A Reference, summarizes basic information on the mining and use of coal, an important source of energy in the US. This report is written for a general audience. The goal is to cover basic material and strike a reasonable compromise between overly generalized statements and detailed analyses. The section ``Supplemental Figures and Tables`` contains statistics, graphs, maps, and other illustrations that show trends, patterns, geographic locations, and similar coal-related information. The section ``Coal Terminology and Related Information`` provides additional information about terms mentioned in the text and introduces some new terms. The last edition of Coal Data: A Reference was published in 1991. The present edition contains updated data as well as expanded reviews and additional information. Added to the text are discussions of coal quality, coal prices, unions, and strikes. The appendix has been expanded to provide statistics on a variety of additional topics, such as: trends in coal production and royalties from Federal and Indian coal leases, hours worked and earnings for coal mine employment, railroad coal shipments and revenues, waterborne coal traffic, coal export loading terminals, utility coal combustion byproducts, and trace elements in coal. The information in this report has been gleaned mainly from the sources in the bibliography. The reader interested in going beyond the scope of this report should consult these sources. The statistics are largely from reports published by the Energy Information Administration.

  10. Sentinel 2 global reference image

    NASA Astrophysics Data System (ADS)

    Dechoz, C.; Poulain, V.; Massera, S.; Languille, F.; Greslou, D.; de Lussy, F.; Gaudel, A.; L'Helguen, C.; Picard, C.; Trémas, T.

    2015-10-01

    Sentinel-2 is a multispectral, high-resolution, optical imaging mission, developed by the European Space Agency (ESA) in the frame of the Copernicus program of the European Commission. In cooperation with ESA, the Centre National d'Etudes Spatiales (CNES) is responsible for the image quality of the project, and will ensure the CAL/VAL commissioning phase. Sentinel-2 mission is devoted the operational monitoring of land and coastal areas, and will provide a continuity of SPOT- and Landsat-type data. Sentinel-2 will also deliver information for emergency services. Launched in 2015 and 2016, there will be a constellation of 2 satellites on a polar sun-synchronous orbit, imaging systematically terrestrial surfaces with a revisit time of 5 days, in 13 spectral bands in visible and shortwave infra-red. Therefore, multi-temporal series of images, taken under the same viewing conditions, will be available. So as to ensure for the multi-temporal registration of the products, specified to be better than 0.3 pixels at 2σ, a Global Reference Image (GRI) will be produced during the CAL/VAL period. This GRI is composed of a set of Sentinel-2 acquisitions, which geometry has been corrected by bundle block adjustment. During L1B processing, Ground Control Points will be taken between this reference image and the sentinel-2 acquisition processed and the geometric model of the image corrected, so as to ensure the good multi-temporal registration. This paper first details the production of the reference during the CALVAL period, and then details the qualification and geolocation performance assessment of the GRI. It finally presents its use in the Level-1 processing chain and gives a first assessment of the multi-temporal registration.

  11. Genetics Home Reference: histidinemia

    MedlinePlus

    ... condition characterized by elevated blood levels of the amino acid histidine, a building block of most proteins. Histidinemia ... Additional Information & Resources MedlinePlus (2 links) Health Topic: Amino Acid Metabolism Disorders Health Topic: Newborn Screening Genetic and ...

  12. Genetics Home Reference: hyperlysinemia

    MedlinePlus

    ... condition characterized by elevated blood levels of the amino acid lysine, a building block of most proteins. Hyperlysinemia ... Additional Information & Resources MedlinePlus (2 links) Health Topic: Amino Acid Metabolism Disorders Health Topic: Newborn Screening Genetic and ...

  13. Nuclear Science References Database

    SciTech Connect

    Pritychenko, B.; Běták, E.; Singh, B.; Totans, J.

    2014-06-15

    The Nuclear Science References (NSR) database together with its associated Web interface, is the world's only comprehensive source of easily accessible low- and intermediate-energy nuclear physics bibliographic information for more than 210,000 articles since the beginning of nuclear science. The weekly-updated NSR database provides essential support for nuclear data evaluation, compilation and research activities. The principles of the database and Web application development and maintenance are described. Examples of nuclear structure, reaction and decay applications are specifically included. The complete NSR database is freely available at the websites of the National Nuclear Data Center (http://www.nndc.bnl.gov/nsr) and the International Atomic Energy Agency (http://www-nds.iaea.org/nsr)

  14. Long life reference electrode

    DOEpatents

    Yonco, Robert M.; Nagy, Zoltan

    1989-01-01

    An external, reference electrode is provided for long term use with a high temperature, high pressure system. The electrode is arranged in a vertical, electrically insulative tube with an upper portion serving as an electrolyte reservior and a lower portion in electrolytic communication with the system to be monitored. The lower end portion includes a flow restriction such as a porous plug to limit the electrolyte release into the system. A piston equalized to the system pressure is fitted into the upper portion of the tube to impart a small incremental pressure to the electrolyte. The piston is selected of suitable size and weight to cause only a slight flow of electrolyte through the porous plug into the high pressure system. This prevents contamination of the electrolyte but is of such small flow rate that operating intervals of a month or more can be achieved.

  15. Long life reference electrode

    DOEpatents

    Yonco, R.M.; Nagy, Z.

    1987-07-30

    An external, reference electrode is provided for long term use with a high temperature, high pressure system. The electrode is arranged in a vertical, electrically insulative tube with an upper portion serving as an electrolyte reservoir and a lower portion in electrolytic communication with the system to be monitored. The lower end portion includes a flow restriction such as a porous plug to limit the electrolyte release into the system. A piston equalized to the system pressure is fitted into the upper portion of the tube to impart a small incremental pressure to the electrolyte. The piston is selected of suitable size and weight to cause only a slight flow of electrolyte through the porous plug into the high pressure system. This prevents contamination of the electrolyte but is of such small flow rate that operating intervals of a month or more can be achieved. 2 figs.

  16. Long life reference electrode

    DOEpatents

    Yonco, R.M.; Nagy, Z.

    1989-04-04

    An external, reference electrode is provided for long term use with a high temperature, high pressure system. The electrode is arranged in a vertical, electrically insulative tube with an upper portion serving as an electrolyte reservoir and a lower portion in electrolytic communication with the system to be monitored. The lower end portion includes a flow restriction such as a porous plug to limit the electrolyte release into the system. A piston equalized to the system pressure is fitted into the upper portion of the tube to impart a small incremental pressure to the electrolyte. The piston is selected of suitable size and weight to cause only a slight flow of electrolyte through the porous plug into the high pressure system. This prevents contamination of the electrolyte but is of such small flow rate that operating intervals of a month or more can be achieved. 2 figs.

  17. PASCAL/48 reference manual

    NASA Technical Reports Server (NTRS)

    Knight, J. C.; Hamm, R. W.

    1984-01-01

    PASCAL/48 is a programming language for the Intel MCS-48 series of microcomputers. In particular, it can be used with the Intel 8748. It is designed to allow the programmer to control most of the instructions being generated and the allocation of storage. The language can be used instead of ASSEMBLY language in most applications while allowing the user the necessary degree of control over hardware resources. Although it is called PASCAL/48, the language differs in many ways from PASCAL. The program structure and statements of the two languages are similar, but the expression mechanism and data types are different. The PASCAL/48 cross-compiler is written in PASCAL and runs on the CDC CYBER NOS system. It generates object code in Intel hexadecimal format that can be used to program the MCS-48 series of microcomputers. This reference manual defines the language, describes the predeclared procedures, lists error messages, illustrates use, and includes language syntax diagrams.

  18. Coastwide Reference Monitoring System (CRMS)

    USGS Publications Warehouse

    2010-01-01

    In 1990, the U.S. Congress enacted the Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) in response to growing awareness of a land loss crisis in Louisiana. Projects funded by CWPPRA require monitoring and evaluation of project effectiveness, and there is also a need to assess the cumulative effects of all projects to achieve a sustainable coastal environment. In 2003, the Louisiana Office of Coastal Protection and Restoration (OCPR) and the U.S. Geological Survey (USGS) received approval from the CWPPRA Task Force to implement the Coastwide Reference Monitoring System (CRMS) as a mechanism to monitor and evaluate the effectiveness of CWPPRA projects at the project, region, and coastwide levels. The CRMS design implements a multiple reference approach by using aspects of hydrogeomorphic functional assessments and probabilistic sampling. The CRMS program is as dynamic as the coastal habitats it monitors. The program is currently funded through CWPPRA and provides data for a variety of user groups, including resource managers, academics, landowners, and researchers.

  19. Reference Artifacts for NDE

    SciTech Connect

    Bono, M; Hibbard, R; Martz, H E

    2003-02-11

    Two reference artifacts will be fabricated for this study. One of the artifacts will have a cylindrical geometry and will contain features similar to those on an SNRT target. The second artifact will have a spherical geometry and will contain features similar to those on a Double Shell target. The artifacts were designed for manufacturability and to provide a range of features that can be measured using NDE methods. The cylindrical reference artifact is illustrated in Figure 1. This artifact consists of a polystyrene body containing two steps and a machined slot, into which will fit a tracer made of doped polystyrene. The polystyrene body contains several grooves and can be fabricated entirely on a diamond turning machine. The body can be machined by turning a PS rod to a diameter slightly greater than the finished diameter of 2 mm. The part can be moved off-axis to face it off and to machine the steps, slot, and grooves. The tracer contains a drilled hole and a milled slot, which could be machined with a single setup on a milling machine. Once assembled, the artifact could be placed in a Be tube or other structure relevant to target assemblies. The assembled artifact will contain many features that could be measured using various NDE methods. Some of these features are: Diameter; Maximum height; Step height; Dimensions of upper step; Radius at the union of the bottom of step and the vertical wall; Sizes of the grooves; Distance from step to groove; Slot width; Slot height; Location of the groove beneath the tracer; Diameter and location of drilled hole in tracer; and Size and location of slot in tracer. The spherical reference artifact is illustrated in Figure 2. This artifact is intended to replicate a double shell target, which consists of concentric polymer spheres separated by aerogel. The artifact consists of an upper hemispherical shell composed of 1% BrCH, which mates via a step joint with a hemispherical component made of polystyrene. This lower component

  20. A structural SVM approach for reference parsing

    PubMed Central

    2011-01-01

    Background Automated extraction of bibliographic data, such as article titles, author names, abstracts, and references is essential to the affordable creation of large citation databases. References, typically appearing at the end of journal articles, can also provide valuable information for extracting other bibliographic data. Therefore, parsing individual reference to extract author, title, journal, year, etc. is sometimes a necessary preprocessing step in building citation-indexing systems. The regular structure in references enables us to consider reference parsing a sequence learning problem and to study structural Support Vector Machine (structural SVM), a newly developed structured learning algorithm on parsing references. Results In this study, we implemented structural SVM and used two types of contextual features to compare structural SVM with conventional SVM. Both methods achieve above 98% token classification accuracy and above 95% overall chunk-level accuracy for reference parsing. We also compared SVM and structural SVM to Conditional Random Field (CRF). The experimental results show that structural SVM and CRF achieve similar accuracies at token- and chunk-levels. Conclusions When only basic observation features are used for each token, structural SVM achieves higher performance compared to SVM since it utilizes the contextual label features. However, when the contextual observation features from neighboring tokens are combined, SVM performance improves greatly, and is close to that of structural SVM after adding the second order contextual observation features. The comparison of these two methods with CRF using the same set of binary features show that both structural SVM and CRF perform better than SVM, indicating their stronger sequence learning ability in reference parsing. PMID:21658294

  1. Sensor Characteristics Reference Guide

    SciTech Connect

    Cree, Johnathan V.; Dansu, A.; Fuhr, P.; Lanzisera, Steven M.; McIntyre, T.; Muehleisen, Ralph T.; Starke, M.; Banerjee, Pranab; Kuruganti, T.; Castello, C.

    2013-04-01

    The Buildings Technologies Office (BTO), within the U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), is initiating a new program in Sensor and Controls. The vision of this program is: • Buildings operating automatically and continuously at peak energy efficiency over their lifetimes and interoperating effectively with the electric power grid. • Buildings that are self-configuring, self-commissioning, self-learning, self-diagnosing, self-healing, and self-transacting to enable continuous peak performance. • Lower overall building operating costs and higher asset valuation. The overarching goal is to capture 30% energy savings by enhanced management of energy consuming assets and systems through development of cost-effective sensors and controls. One step in achieving this vision is the publication of this Sensor Characteristics Reference Guide. The purpose of the guide is to inform building owners and operators of the current status, capabilities, and limitations of sensor technologies. It is hoped that this guide will aid in the design and procurement process and result in successful implementation of building sensor and control systems. DOE will also use this guide to identify research priorities, develop future specifications for potential market adoption, and provide market clarity through unbiased information

  2. COSY INFINITY reference manual

    SciTech Connect

    Berz, M.

    1990-07-01

    This is a reference manual for the arbitrary order particle optics and beam dynamics code COSY INFINITY. It is current as of June 28, 1990. COSY INFINITY is a code to study and design particle optical systems, including beamlines, spectrometers, and particle accelerators. At its core it is using differential algebraic (DA) methods, which allow a very systematic and simple calculation of high order effects. At the same time, it allows the computation of dependences on system parameters, which is often interesting in its own right and can also be used for fitting. COSY INFINITY has a full structured object oriented language environment. This provides a simple interface for the casual user. At the same time, it offers the demanding user a very flexible and powerful tool for the study and design of systems, and more generally, the utilization of DA methods. The power and generality of the environment is perhaps best demonstrated by the fact that the physics routines of COSY INFINITY are written in its own input language and are very compact. The approach also considerably facilitates the implementation of new features because they are incorporated with the same commands that are used for design and study. 26 refs.

  3. Rats exhibit reference-dependent choice behavior.

    PubMed

    Bhatti, Mehwish; Jang, Hyeran; Kralik, Jerald D; Jeong, Jaeseung

    2014-07-01

    Human preferences depend on whether a chosen outcome appears to be a loss or a gain compared with what had been expected, i.e., in comparison to a reference point. Because reference dependence has such a strong influence on human decision-making, it is important to uncover its origins, which will in turn help delineate the underlying mechanisms. It remains unknown whether rats use reference points in decision-making, and yet, the study of rats could help address the question of whether reference dependence is evolutionarily conserved among mammals and could provide a nonhuman animal model to investigate the neural mechanisms underlying this important cognitive process. The aim of the current study was to determine whether rats show reference-dependent choice behavior. We developed a novel paradigm by modifying the "T" maze by installing "pockets" to the left and right of the "T" stem that held reward pellets so rats would potentially develop reference values for each option prior to choice. We found that the rats were indeed sensitive to the way alternatives were presented. That is, they exhibited reference-dependent choice behavior by avoiding the choice option framed as a loss (e.g., having four reward pellets in the pocket, but receiving only one), at least under conditions with certain outcomes and clear differences between the reference and outcome quantities. Despite the small number of rats in this study, this species-level capacity suggests that reference dependence in general and loss aversion in particular may be conserved traits that evolved at or before the emergence of mammals.

  4. Eddy-Current Reference Standard

    NASA Technical Reports Server (NTRS)

    Ambrose, H. H., Jr.

    1985-01-01

    Magnetic properties of metallic reference standards duplicated and stabilized for eddy-current coil measurements over long times. Concept uses precisely machined notched samples of known annealed materials as reference standards.

  5. Students' Perceptions of Reference Letters

    ERIC Educational Resources Information Center

    Payne, Brian K.; Appel, Jonathan; Smith, Donald H.; Hoofnagle, Kara

    2006-01-01

    This study examines students' perceptions of reference letters. Students (n = 444) were asked to describe how they perceived reference letters. Four themes were uncovered. First, some students perceived reference letters as useful for employers. Second, some students perceived the letters as important for students seeking employment or admission…

  6. Fundamentals of Managing Reference Collections

    ERIC Educational Resources Information Center

    Singer, Carol A.

    2012-01-01

    Whether a library's reference collection is large or small, it needs constant attention. Singer's book offers information and insight on best practices for reference collection management, no matter the size, and shows why managing without a plan is a recipe for clutter and confusion. In this very practical guide, reference librarians will learn:…

  7. Knowledge Management and Reference Services

    ERIC Educational Resources Information Center

    Gandhi, Smiti

    2004-01-01

    Many corporations are embracing knowledge management (KM) to capture the intellectual capital of their employees. This article focuses on KM applications for reference work in libraries. It defines key concepts of KM, establishes a need for KM for reference services, and reviews various KM initiatives for reference services.

  8. Reference Policies and Procedures Manual.

    ERIC Educational Resources Information Center

    George Mason Univ., Fairfax, VA.

    This guide to services of the reference department of Fenwick Library, George Mason University, is intended for use by staff in the department, as well as the general public. Areas covered include (1) reference desk services to users; (2) reference desk support procedures; (3) off desk services; (4) collection development, including staff…

  9. Web Reference: A Virtual Reality.

    ERIC Educational Resources Information Center

    Foster, Janet

    1999-01-01

    Presents ideas and strategies to enhance digital reference services available via the Internet in public libraries. Describes print publications which include Web reference columns; subject guides, both print and online; and the resources of the Internet Public Library and other virtual reference desks. (LRW)

  10. Gender agreement and multiple referents.

    PubMed

    Finocchiaro, Chiara; Mahon, Bradford Z; Caramazza, Alfonso

    2008-01-01

    We report a new pattern of usage in current, spoken Italian that has implications for both psycholinguistic models of language production and linguistic theories of language change. In Italian, gender agreement is mandatory for both singular and plural nouns. However, when two or more nouns of different grammatical gender appear in a conjoined noun phrase (NP), masculine plural agreement is required. In this study, we combined on-line and off-line methodologies in order to assess the mechanisms involved in gender marking in the context of multiple referents. The results of two pronoun production tasks showed that plural feminine agreement was significantly more difficult than plural masculine agreement. In a separate study using offline judgements of acceptability, we found that agreement violations in Italian are tolerated more readily in the case of feminine conjoined noun phrases (e.g., la mela e la banana 'the:fem apple:fem and the: fem banana: fem') than masculine conjoined noun phrases (e.g., il fiore e il libro 'the:mas flower: mas and the:mas book:mas'). Implications of these results are discussed both at the level of functional architecture within the language production system and at the level of changes in language use. PMID:21037930

  11. Gender agreement and multiple referents.

    PubMed

    Finocchiaro, Chiara; Mahon, Bradford Z; Caramazza, Alfonso

    2008-01-01

    We report a new pattern of usage in current, spoken Italian that has implications for both psycholinguistic models of language production and linguistic theories of language change. In Italian, gender agreement is mandatory for both singular and plural nouns. However, when two or more nouns of different grammatical gender appear in a conjoined noun phrase (NP), masculine plural agreement is required. In this study, we combined on-line and off-line methodologies in order to assess the mechanisms involved in gender marking in the context of multiple referents. The results of two pronoun production tasks showed that plural feminine agreement was significantly more difficult than plural masculine agreement. In a separate study using offline judgements of acceptability, we found that agreement violations in Italian are tolerated more readily in the case of feminine conjoined noun phrases (e.g., la mela e la banana 'the:fem apple:fem and the: fem banana: fem') than masculine conjoined noun phrases (e.g., il fiore e il libro 'the:mas flower: mas and the:mas book:mas'). Implications of these results are discussed both at the level of functional architecture within the language production system and at the level of changes in language use.

  12. Gender agreement and multiple referents

    PubMed Central

    Finocchiaro, Chiara; Mahon, Bradford Z.; Caramazza, Alfonso

    2010-01-01

    We report a new pattern of usage in current, spoken Italian that has implications for both psycholinguistic models of language production and linguistic theories of language change. In Italian, gender agreement is mandatory for both singular and plural nouns. However, when two or more nouns of different grammatical gender appear in a conjoined noun phrase (NP), masculine plural agreement is required. In this study, we combined on-line and off-line methodologies in order to assess the mechanisms involved in gender marking in the context of multiple referents. The results of two pronoun production tasks showed that plural feminine agreement was significantly more difficult than plural masculine agreement. In a separate study using offline judgements of acceptability, we found that agreement violations in Italian are tolerated more readily in the case of feminine conjoined noun phrases (e.g., la mela e la banana ‘the:fem apple:fem and the: fem banana: fem’) than masculine conjoined noun phrases (e.g., il fiore e il libro ‘the:mas flower: mas and the:mas book:mas’). Implications of these results are discussed both at the level of functional architecture within the language production system and at the level of changes in language use.* PMID:21037930

  13. Magnifying Devices: A Resource Guide. Reference Circular.

    ERIC Educational Resources Information Center

    Strauss, Carol, Comp.

    The devices listed in this reference circular are designed to assist people who have visual impairments by magnifying objects and print or graphic materials. Before buying a magnification device, one should consult a low-vision specialist to determine the level of usable vision, the power of magnification needed for a particular eye condition and…

  14. Generic Crystalline Disposal Reference Case

    SciTech Connect

    Painter, Scott Leroy; Chu, Shaoping; Harp, Dylan Robert; Perry, Frank Vinton; Wang, Yifeng

    2015-02-20

    A generic reference case for disposal of spent nuclear fuel and high-level radioactive waste in crystalline rock is outlined. The generic cases are intended to support development of disposal system modeling capability by establishing relevant baseline conditions and parameters. Establishment of a generic reference case requires that the emplacement concept, waste inventory, waste form, waste package, backfill/buffer properties, EBS failure scenarios, host rock properties, and biosphere be specified. The focus in this report is on those elements that are unique to crystalline disposal, especially the geosphere representation. Three emplacement concepts are suggested for further analyses: a waste packages containing 4 PWR assemblies emplaced in boreholes in the floors of tunnels (KBS-3 concept), a 12-assembly waste package emplaced in tunnels, and a 32-assembly dual purpose canister emplaced in tunnels. In addition, three failure scenarios were suggested for future use: a nominal scenario involving corrosion of the waste package in the tunnel emplacement concepts, a manufacturing defect scenario applicable to the KBS-3 concept, and a disruptive glaciation scenario applicable to both emplacement concepts. The computational approaches required to analyze EBS failure and transport processes in a crystalline rock repository are similar to those of argillite/shale, with the most significant difference being that the EBS in a crystalline rock repository will likely experience highly heterogeneous flow rates, which should be represented in the model. The computational approaches required to analyze radionuclide transport in the natural system are very different because of the highly channelized nature of fracture flow. Computational workflows tailored to crystalline rock based on discrete transport pathways extracted from discrete fracture network models are recommended.

  15. Occupational exposure to intermediate frequency and extremely low frequency magnetic fields among personnel working near electronic article surveillance systems.

    PubMed

    Roivainen, Päivi; Eskelinen, Tuomo; Jokela, Kari; Juutilainen, Jukka

    2014-05-01

    Cashiers are potentially exposed to intermediate frequency (IF) magnetic fields at their workplaces because of the electronic article surveillance (EAS) systems used in stores to protect merchandise against theft. This study aimed at investigating occupational exposure of cashiers to IF magnetic fields in Finnish stores. Exposure to extremely low frequency (ELF) magnetic fields was also evaluated because cashiers work near various devices operating with 50 Hz electric power. The peak magnetic flux density was measured for IF magnetic fields, and was found to vary from 0.2 to 4 µT at the cashier's seat. ELF magnetic fields from 0.03 to 4.5 µT were found at the cashier's seat. These values are much lower than exposure limits. However, according to the International Commission on Non-Ionizing Radiation Protection (ICNIRP) occupational reference levels for IF magnetic fields (141 µT for the peak field) were exceeded in some cases (maximum 189 µT) for short periods of time when cashiers walked through the EAS gates. As the ICNIRP reference levels do not define any minimum time for exposure, additional investigations are recommended to determine compliance with basic restrictions. Even if the basic restrictions are not exceeded, persons working near EAS devices represent an exceptional group of workers with respect to exposure to electromagnetic fields. This group could serve as a basis for epidemiological studies addressing possible health effects of IF magnetic fields. Compliance with the reference levels for IF fields was evaluated using both broadband measurement of peak fields and the ICNIRP summation rule for multiple frequencies. The latter was generally more conservative, and the difference between the two methods was large (>10-fold) for EAS systems using a 58 kHz signal with complex waveform. This indicates that the ICNIRP multiple frequency rule can be unnecessarily conservative when measuring complex waveforms.

  16. VIEWCACHE: An incremental pointer-base access method for distributed databases. Part 1: The universal index system design document. Part 2: The universal index system low-level design document. Part 3: User's guide. Part 4: Reference manual. Part 5: UIMS test suite

    NASA Technical Reports Server (NTRS)

    Kelley, Steve; Roussopoulos, Nick; Sellis, Timos

    1992-01-01

    The goal of the Universal Index System (UIS), is to provide an easy-to-use and reliable interface to many different kinds of database systems. The impetus for this system was to simplify database index management for users, thus encouraging the use of indexes. As the idea grew into an actual system design, the concept of increasing database performance by facilitating the use of time-saving techniques at the user level became a theme for the project. This Final Report describes the Design, the Implementation of UIS, and its Language Interfaces. It also includes the User's Guide and the Reference Manual.

  17. Capillary reference half-cell

    DOEpatents

    Hall, Stephen H.

    1996-01-01

    The present invention is a reference half-cell electrode wherein intermingling of test fluid with reference fluid does not affect the performance of the reference half-cell over a long time. This intermingling reference half-cell may be used as a single or double junction submersible or surface reference electrode. The intermingling reference half-cell relies on a capillary tube having a first end open to reference fluid and a second end open to test fluid wherein the small diameter of the capillary tube limits free motion of fluid within the capillary to diffusion. The electrode is placed near the first end of the capillary in contact with the reference fluid. The method of operation of the present invention begins with filling the capillary tube with a reference solution. After closing the first end of the capillary, the capillary tube may be fully submerged or partially submerged with the second open end inserted into test fluid. Since the electrode is placed near the first end of the capillary, and since the test fluid may intermingle with the reference fluid through the second open end only by diffusion, this intermingling capillary reference half-cell provides a stable voltage potential for long time periods.

  18. Capillary reference half-cell

    DOEpatents

    Hall, S.H.

    1996-02-13

    The present invention is a reference half-cell electrode wherein intermingling of test fluid with reference fluid does not affect the performance of the reference half-cell over a long time. This intermingling reference half-cell may be used as a single or double junction submersible or surface reference electrode. The intermingling reference half-cell relies on a capillary tube having a first end open to reference fluid and a second end open to test fluid wherein the small diameter of the capillary tube limits free motion of fluid within the capillary to diffusion. The electrode is placed near the first end of the capillary in contact with the reference fluid. The method of operation of the present invention begins with filling the capillary tube with a reference solution. After closing the first end of the capillary, the capillary tube may be fully submerged or partially submerged with the second open end inserted into test fluid. Since the electrode is placed near the first end of the capillary, and since the test fluid may intermingle with the reference fluid through the second open end only by diffusion, this intermingling capillary reference half-cell provides a stable voltage potential for long time periods. 11 figs.

  19. Reference in single sentences and in texts.

    PubMed

    Crawley, R A; Stevenson, R J

    1990-05-01

    This study investigated the comprehension and production of reference terms in both sentences (Experiments 1 and 2) and texts (Experiments 3 and 4) using a sentence completion task. In Experiments 1 and 2, the use of a sentence-level strategy (subject assignment) was investigated. In Experiments 3 and 4, the use of a text-level strategy (topic assignment) was also investigated. There was a clear preference for continuing the sentences by referring to the subjects of the sentences regardless of the availability of gender cues, in both single sentences and in texts. There was also an influence of the topic of each text on both the choice of referent and the type of reference term used. However, the choice of reference term was affected by the number of potential antecedents in the preceding text. Overall, the results suggest that the sentence subject is a salient item in working memory. This salience is increased if the sentence subject is also the textual topic. In addition, it appears that the presence of a pronoun in a text triggers a specific strategy to assign the pronoun to the (salient) sentence subject. PMID:2231478

  20. Co-reference and reasoning.

    PubMed

    Walsh, Clare R; Johnson-Laird, P N

    2004-01-01

    Co-reference occurs when two or more noun phrases refer to the same individual, as in the following inferential problem: Mark is kneeling by the fire or he is looking at the TV but not both. / Mark is kneeling by the fire. / Is he looking at the TV? In three experiments, we compared co-referential reasoning problems with problems referring to different individuals. Experiment 1 showed that co-reference improves accuracy. In Experiment 2, we replicated that finding and showed that co-reference speeds up both reading and inference. Experiment 3 showed that the effects of co-reference are greatest when the premises and the conclusion share co-referents. These effects led the participants to make illusory inferences--that is, to draw systematically invalid conclusions. The results are discussed in terms of the mental model theory of reasoning.

  1. Uranium recovery from low-level aqueous sources. [76 references

    SciTech Connect

    Kelmers, A.D.; Goeller, H.E.

    1981-03-01

    The aqueous sources of soluble uranium were surveyed and evaluated in terms of the uranium geochemical cycle in an effort to identify potential unexploited resources. Freshwater sources appeared to be too low in uranium content to merit consideration, while seawater, although very dilute (approx. 3.3 ppB), contains approx. 4 x 10/sup 9/ metric tons of uranium in all the world's oceans. A literature review of recent publications and patents concerning uranium recovery from seawater was conducted. Considerable experimental work is currently under way in Japan; less is being done in the European countries. An assessment of the current state of technology is presented in this report. Repeated screening programs have identified hydrous titanium oxide as the most promising candidate absorbent. However, some of its properties such as distribution coefficient, selectivity, loading, and possibly stability appear to render its use inadequate in a practical recovery system. Also, various assessments of the energy efficiency of pumped or tidal power schemes for contacting the sorbent and seawater are in major disagreement. Needed future research and development tasks are discussed. A fundamental sorbent development program to greatly improve sorbent properties would be required to permit practical recovery of uranium from seawater. Major unresolved engineering aspects of such recovery systems are also identified and discussed.

  2. The Prominence of Referring Expressions: Message and Lexical Level Effects

    ERIC Educational Resources Information Center

    Lam, Tuan Q.

    2012-01-01

    In conversation, speakers produce some words with greater intensity, longer duration, and higher fundamental frequency (F0) than other words. By making different words in a sentence more prominent than other words, a speaker can change the meaning implied by a sentence. This thesis explores the relationship between processing in the language…

  3. Optical probe with reference fiber

    DOEpatents

    Da Silva, Luiz B.; Chase, Charles L.

    2006-03-14

    A system for characterizing tissue includes the steps of generating an emission signal, generating a reference signal, directing the emission signal to and from the tissue, directing the reference signal in a predetermined manner relative to the emission signal, and using the reference signal to compensate the emission signal. In one embodiment compensation is provided for fluctuations in light delivery to the tip of the probe due to cable motion.

  4. Reach for Reference: Elementary-Middle School Science Reference Collections

    ERIC Educational Resources Information Center

    Safford, Barbara Ripp

    2005-01-01

    This article presents a brief review of some new school science reference works. Two of the sources are traditional, while one is considered experimental. The two traditional reference works reviewed are "The American Heritage Children's Science Dictionary" for upper elementary grades, and "The American Heritage Student Science Dictionary" for…

  5. Statewide Supplemental Reference Service: New Jersey's Model for Backup Reference.

    ERIC Educational Resources Information Center

    Bromberg, Peter

    2001-01-01

    Discusses the history of backup reference service in the state of New Jersey including the transition from regional backup service; describes the current statewide service; and considers future service possibilities in light of recent trends, including a decrease in the number of reference questions being received in libraries. (LRW)

  6. Reference Frames in Earth Rotation Theories

    NASA Astrophysics Data System (ADS)

    Ferrándiz, José M.; Belda, Santiago; Heinkelmann, Robert; Getino, Juan; Schuh, Harald; Escapa, Alberto

    2015-04-01

    Nowadays the determination of the Earth Orientation Parameters (EOP) and the different Terrestrial Reference Frames (TRF) are not independent. The available theories of Earth rotation aims at providing the orientation of a certain reference system linked somehow to the Earth with respect to a given celestial system, considered as inertial. In the past years a considerable effort has been dedicated to the improvement of the TRF realizations, following the lines set up in the 1980's. However, the reference systems used in the derivation of the theories have been rather considered as something fully established, not deserving a special attention. In this contribution we review the definitions of the frames used in the main theoretical approaches, focusing on those used in the construction of IAU2000, and the extent to which their underlying hypotheses hold. The results are useful to determine the level of consistency of the predicted and determined EOP.

  7. Reference values for methemoglobin concentrations in children

    PubMed Central

    Rechetzki, Kely Francini; Henneberg, Railson; da Silva, Paulo Henrique; do Nascimento, Aguinaldo José

    2012-01-01

    Objective The aim of this work was to establish reference values for methemoglobin levels in 6 to 10-year-old children. Methods Methemoglobin concentrations were studied in clinically healthy children. The method for methemoglobin measurement used, neither uses highly toxic chemical compounds nor expensive enzymatic methods, thus it is feasible in the laboratory routine. Results The results showed higher reference values for clinically healthy children (from 3.61 to 6.44%) than for adults (from 1.9 to 3.8%). Conclusion The higher concentrations of methemoglobin in children may be explained by smaller amounts of soluble cofactor cytochrome b5 and reduced activity of the cytochrome b5 reductase enzyme in red blood cells which make children particularly susceptible to the development of methemoglobinemia. Methemoglobin concentrations in children are higher than in normal adult subjects thus, adult reference values cannot be used to interpret infant methemoglobinemia. PMID:23049377

  8. Reference Readiness for AV Questions.

    ERIC Educational Resources Information Center

    Drolet, Leon L., Jr.

    1981-01-01

    Reviews 50 reference tools which librarians can use to answer almost any audiovisual question including queries on trivia, equipment selection, biographical information, and motion picture ratings. (LLS)

  9. In vitro evaluation of genotoxic effects under magnetic resonant coupling wireless power transfer.

    PubMed

    Mizuno, Kohei; Shinohara, Naoki; Miyakoshi, Junji

    2015-04-01

    Wireless power transfer (WPT) technology using the resonant coupling phenomenon has been widely studied, but there are very few studies concerning the possible relationship between WPT exposure and human health. In this study, we investigated whether exposure to magnetic resonant coupling WPT has genotoxic effects on WI38VA13 subcloned 2RA human fibroblast cells. WPT exposure was performed using a helical coil-based exposure system designed to transfer power with 85.4% efficiency at a 12.5-MHz resonant frequency. The magnetic field at the positions of the cell culture dishes is approximately twice the reference level for occupational exposure as stated in the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines. The specific absorption rate at the positions of the cell culture dishes matches the respective reference levels stated in the ICNIRP guidelines. For assessment of genotoxicity, we studied cell growth, cell cycle distribution, DNA strand breaks using the comet assay, micronucleus formation, and hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene mutation, and did not detect any significant effects between the WPT-exposed cells and control cells. Our results suggest that WPT exposure under the conditions of the ICNIRP guidelines does not cause detectable cellular genotoxicity. PMID:25853218

  10. In Vitro Evaluation of Genotoxic Effects under Magnetic Resonant Coupling Wireless Power Transfer

    PubMed Central

    Mizuno, Kohei; Shinohara, Naoki; Miyakoshi, Junji

    2015-01-01

    Wireless power transfer (WPT) technology using the resonant coupling phenomenon has been widely studied, but there are very few studies concerning the possible relationship between WPT exposure and human health. In this study, we investigated whether exposure to magnetic resonant coupling WPT has genotoxic effects on WI38VA13 subcloned 2RA human fibroblast cells. WPT exposure was performed using a helical coil-based exposure system designed to transfer power with 85.4% efficiency at a 12.5-MHz resonant frequency. The magnetic field at the positions of the cell culture dishes is approximately twice the reference level for occupational exposure as stated in the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines. The specific absorption rate at the positions of the cell culture dishes matches the respective reference levels stated in the ICNIRP guidelines. For assessment of genotoxicity, we studied cell growth, cell cycle distribution, DNA strand breaks using the comet assay, micronucleus formation, and hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene mutation, and did not detect any significant effects between the WPT-exposed cells and control cells. Our results suggest that WPT exposure under the conditions of the ICNIRP guidelines does not cause detectable cellular genotoxicity. PMID:25853218

  11. A comparison of foetal SAR in three sets of pregnant female models

    NASA Astrophysics Data System (ADS)

    Dimbylow, Peter J.; Nagaoka, Tomoaki; Xu, X. George

    2009-05-01

    This paper compares the foetal SAR in the HPA hybrid mathematical phantoms with the 26-week foetal model developed at the National Institute of Information and Communications Technology, Tokyo, and the set of 13-, 26- and 38-week boundary representation models produced at Rensselaer Polytechnic Institute. FDTD calculations are performed at a resolution of 2 mm for a plane wave with a vertically aligned electric field incident upon the body from the front, back and two sides from 20 MHz to 3 GHz under isolated conditions. The external electric field values required to produce the ICNIRP public exposure localized restriction of 2 W kg-1 when averaged over 10 g of the foetus are compared with the ICNIRP reference levels.

  12. Connecting VLBI and Gaia celestial reference frames

    NASA Astrophysics Data System (ADS)

    Malkin, Zinovy

    2016-09-01

    The current state of the link problem between radio and optical celestial reference frames is considered. The main objectives of the investigations in this direction during the next few years are the preparation of a comparison and the mutual orientation and rotation between the optical Gaia Celestial Reference Frame (GCRF) and the 3rd generation radio International Celestial Reference Frame (ICRF3), obtained from VLBI observations. Both systems, ideally, should be a realization of the ICRS (International Celestial Reference System) at micro-arcsecond level accuracy. Therefore, the link accuracy between the ICRF and GCRF should be obtained with similar error level, which is not a trivial task due to relatively large systematic and random errors in source positions at different frequency bands. In this paper, a brief overview of recent work on the GCRF--ICRF link is presented. Additional possibilities to improve the GCRF--ICRF link accuracy are discussed. The suggestion is made to use astrometric radio sources with optical magnitude to 20^m rather than to 18^m as currently planned for the GCRF--ICRF link. In addition, the use of radio stars is also a prospective method to obtain independent and accurate orientation between the Gaia frame and the ICRF.

  13. Robot at the Reference Desk?

    ERIC Educational Resources Information Center

    Smith, Karen F.

    1986-01-01

    Describes how a librarian, assisted by a knowledge engineer, developed a computerized reference assistance system for a separate government documents department. Rationale for the expert system, problems in selecting reference materials and user questions to computerize, and the formulation of a workable human/computer interface are covered. A…

  14. Are Reference Desks Dying Out?

    ERIC Educational Resources Information Center

    Carlson, Scott

    2007-01-01

    This article examines how librarians are struggling to redefine, and in some cases eliminate, the venerable institution of reference desk services and it explores the new ways in which reference questions get answered at university libraries. These include fielding questions through e-mail, instant messaging, and other mobile technologies, making…

  15. Expert Systems for Reference Work.

    ERIC Educational Resources Information Center

    Parrot, James R.

    1986-01-01

    Discussion of library reference work that may be suitable for use of expert systems focuses on (1) information and literature searches, and (2) requests to interpret bibliographic references and locate items listed. Systems and computer-assisted instruction modules designed for information retrieval at the University of Waterloo Library are…

  16. Queuing Theory and Reference Transactions.

    ERIC Educational Resources Information Center

    Terbille, Charles

    1995-01-01

    Examines the implications of applying the queuing theory to three different reference situations: (1) random patron arrivals; (2) random durations of transactions; and (3) use of two librarians. Tables and figures represent results from spreadsheet calculations of queues for each reference situation. (JMV)

  17. The Virtual Reference Librarian's Handbook.

    ERIC Educational Resources Information Center

    Lipow, Anne Grodzins

    This book is a practical guide to librarians and their administrators who are thinking about or in the early stages of providing virtual reference service. Part 1, "The Decision to Go Virtual," provides a context for thinking about virtual reference, including the benefits and problems, getting in the virtual frame of mind, and shopping for…

  18. Improved ultrasonic standard reference blocks

    NASA Technical Reports Server (NTRS)

    Eitzen, D. G.; Sushinsky, G. F.; Chwirut, D. J.; Bechtoldt, C. J.; Ruff, A. W.

    1976-01-01

    A program to improve the quality, reproducibility and reliability of nondestructive testing through the development of improved ASTM-type ultrasonic reference standards is described. Reference blocks of aluminum, steel, and titanium alloys are to be considered. Equipment representing the state-of-the-art in laboratory and field ultrasonic equipment was obtained and evaluated. RF and spectral data on ten sets of ultrasonic reference blocks have been taken as part of a task to quantify the variability in response from nominally identical blocks. Techniques for residual stress, preferred orientation, and micro-structural measurements were refined and are applied to a reference block rejected by the manufacturer during fabrication in order to evaluate the effect of metallurgical condition on block response. New fabrication techniques for reference blocks are discussed and ASTM activities are summarized.

  19. Human epididymis protein 4 reference limits and natural variation in a Nordic reference population.

    PubMed

    Bolstad, Nils; Øijordsbakken, Miriam; Nustad, Kjell; Bjerner, Johan

    2012-02-01

    The objectives of this study are to establish reference limits for human epididymis protein 4, HE4, and investigate factors influencing HE4 levels in healthy subjects. HE4 was measured in 1,591 samples from the Nordic Reference Interval Project Bio-bank and Database biobank, using the manual HE4 EIA (Fujirebio) for 802 samples and the Architect HE4 (Abbott) for 792 samples. Reference limits were calculated using the statistical software R. The influence of donor characteristics such as age, sex, body mass index, smoking habits, and creatinine on HE4 levels was investigated using a multivariate model. The study showed that age is the main determinant of HE4 in healthy subjects, corresponding to 2% higher HE4 levels at 30 years (compared to 20 years), 9% at 40 years, 20% at 50 years, 37% at 60 years, 63% at 70 years, and 101% at 80 years. HE4 levels are 29% higher in smokers than in nonsmokers. In conclusion, HE4 levels in healthy subjects are associated with age and smoking status. Age-dependent reference limits are suggested.

  20. Current level detector

    DOEpatents

    Kerns, Cordon R.

    1977-01-01

    A device is provided for detecting the current level of a DC signal. It includes an even harmonic modulator to which a reference AC signal is applied. The unknown DC signal acts on the reference AC signal so that the output of the modulator includes an even harmonic whose amplitude is proportional to the unknown DC current.

  1. The International Geomagnetic Reference Field, 2005

    USGS Publications Warehouse

    Rukstales, Kenneth S.; Love, Jeffrey J.

    2007-01-01

    This is a set of five world charts showing the declination, inclination, horizontal intensity, vertical component, and total intensity of the Earth's magnetic field at mean sea level at the beginning of 2005. The charts are based on the International Geomagnetic Reference Field (IGRF) main model for 2005 and secular change model for 2005-2010. The IGRF is referenced to the World Geodetic System 1984 ellipsoid. Additional information about the USGS geomagnetism program is available at: http://geomag.usgs.gov/

  2. Bioregenerative life support - The initial CELSS reference configuration

    NASA Technical Reports Server (NTRS)

    Rummel, John D.; Averner, Mel

    1991-01-01

    The next major step in the development of an operational Controlled Ecological Life-Support System (CELSS) is the creation of a human-rated ground-based demonstrator able to constitute a CELSS's proof-of-concept. The reference configuration recently devised for such a ground facility by NASA will furnish a common reference to all investigators in the field, thereby facilitating performance comparisons among candidate subsystems and clarifying system-level modeling. A detailed NASA reference CELSS flowcharting is presented.

  3. Reference and Standard Atmosphere Models

    NASA Technical Reports Server (NTRS)

    Johnson, Dale L.; Roberts, Barry C.; Vaughan, William W.; Parker, Nelson C. (Technical Monitor)

    2002-01-01

    This paper describes the development of standard and reference atmosphere models along with the history of their origin and use since the mid 19th century. The first "Standard Atmospheres" were established by international agreement in the 1920's. Later some countries, notably the United States, also developed and published "Standard Atmospheres". The term "Reference Atmospheres" is used to identify atmosphere models for specific geographical locations. Range Reference Atmosphere Models developed first during the 1960's are examples of these descriptions of the atmosphere. This paper discusses the various models, scopes, applications and limitations relative to use in aerospace industry activities.

  4. Computerizing the Reference Desk Schedule.

    ERIC Educational Resources Information Center

    deHaas, Pat

    1983-01-01

    Discussion of the scheduling procedures of librarians' hours at the reference desk at the Rutherford Humanities and Social Sciences Library, University of Alberta, highlights services provided, the preference table system, and manual scheduling versus computer scheduling. (EJS)

  5. Genetics Home Reference: WAGR syndrome

    MedlinePlus

    ... signs and symptoms of WAGR syndrome can include childhood-onset obesity, inflammation of the pancreas (pancreatitis), and kidney failure. When WAGR syndrome includes childhood-onset obesity, it is often referred to as WAGRO syndrome. ...

  6. Improved ultrasonic standard reference blocks

    NASA Technical Reports Server (NTRS)

    Eitzen, D. G.

    1975-01-01

    A program to improve the quality, reproducibility and reliability of nondestructive testing through the development of improved ASTM-type ultrasonic reference standards is described. Reference blocks of aluminum, steel, and titanium alloys were considered. Equipment representing the state-of-the-art in laboratory and field ultrasonic equipment was obtained and evaluated. Some RF and spectral data on ten sets of ultrasonic reference blocks were taken as part of a task to quantify the variability in response from nominally identical blocks. Techniques for residual stress, preferred orientation, and microstructural measurements were refined and are applied to a reference block rejected by the manufacturer during fabrication in order to evaluate the effect of metallurgical condition on block response.

  7. Africa South of the Sahara: A Guide to Reference Sources.

    ERIC Educational Resources Information Center

    Mason, Mary, Comp.

    This annotated bibliography has been compiled as an introduction to reference resources for college-level African studies and to suggest useful tools for literature searches. It is a guide to materials in the library of McGill University. Call numbers are included. The titles cited refer to Africa South of the Sahara as a whole or to large…

  8. Space Station reference configuration description

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The data generated by the Space Station Program Skunk Works over a period of 4 months which supports the definition of a Space Station reference configuration is documented. The data were generated to meet these objectives: (1) provide a focal point for the definition and assessment of program requirements; (2) establish a basis for estimating program cost; and (3) define a reference configuration in sufficient detail to allow its inclusion in the definition phase Request for Proposal (RFP).

  9. Sequence Factorization with Multiple References

    PubMed Central

    Wandelt, Sebastian; Leser, Ulf

    2015-01-01

    The success of high-throughput sequencing has lead to an increasing number of projects which sequence large populations of a species. Storage and analysis of sequence data is a key challenge in these projects, because of the sheer size of the datasets. Compression is one simple technology to deal with this challenge. Referential factorization and compression schemes, which store only the differences between input sequence and a reference sequence, gained lots of interest in this field. Highly-similar sequences, e.g., Human genomes, can be compressed with a compression ratio of 1,000:1 and more, up to two orders of magnitude better than with standard compression techniques. Recently, it was shown that the compression against multiple references from the same species can boost the compression ratio up to 4,000:1. However, a detailed analysis of using multiple references is lacking, e.g., for main memory consumption and optimality. In this paper, we describe one key technique for the referential compression against multiple references: The factorization of sequences. Based on the notion of an optimal factorization, we propose optimization heuristics and identify parameter settings which greatly influence 1) the size of the factorization, 2) the time for factorization, and 3) the required amount of main memory. We evaluate a total of 30 setups with a varying number of references on data from three different species. Our results show a wide range of factorization sizes (optimal to an overhead of up to 300%), factorization speed (0.01 MB/s to more than 600 MB/s), and main memory usage (few dozen MB to dozens of GB). Based on our evaluation, we identify the best configurations for common use cases. Our evaluation shows that multi-reference factorization is much better than single-reference factorization. PMID:26422374

  10. Dietary Reference Intakes for Koreans (KDRIs).

    PubMed

    Paik, Hee Young

    2008-01-01

    For more than 40 years, Recommended Dietary Allowances for Koreans (KRDA) were used as references for nutrient intake. In 2002, the Korean Nutrition Society organized a committee to revise the KRDA, which were transformed into the new Dietary Reference Intakes for Koreans (KDRIs) in 2005. KDRIs include Estimated Average Requirements (EAR), Recommended Intake (RI), Adequate Intake (AI) and Tolerable Upper Intake Level (UL) for protein, essential amino acids and micronutrients, Estimated Energy Requirement (EER) for energy and Acceptable Macronutrients Distribution Ranges (AMDR) for macronutrients. Evidence-based methods were used to determine the reference value (s) and the levels of nutrient intake for each nutrient. The KDRIs expanded significantly the number of nutrients and the basic concepts of nutrient recommendations compared to the previously used KRDA. In addition, a new food guide, depicted as Food Tower for Koreans, was developed and appended to the KDRIs publication. Continued efforts are needed to facilitate the application of KDRIs as well as to improve the understanding of the concepts. Additional modifications will be made as more scientific data become available.

  11. Characterization of interim reference shales

    SciTech Connect

    Miknis, F.P.; Sullivan, S.; Mason, G.

    1986-03-01

    Measurements have been made on the chemical and physical properties of two oil shales designated as interim reference oil shales by the Department of Energy. One oil shale is a Green River Formation, Parachute Creek Member, Mahogany Zone Colorado oil shale from the Anvil Points mine and the other is a Clegg Creek Member, New Albany shale from Kentucky. Material balance Fischer assays, kerogen concentrates, carbon aromaticities, thermal properties, and bulk mineralogic properties have been determined for the oil shales. The measured properties of the interim reference shales are comparable to results obtained from previous studies on similar shales. The western interim reference shale has a low carbon aromaticity, high Fischer assay conversion to oil, and a dominant carbonate mineralogy. The eastern interim reference shale has a high carbon aromaticity, low Fischer assay conversion to oil, and a dominant silicate mineralogy. Chemical and physical properties, including ASTM distillations, have been determined for shale oils produced from the interim reference shales. The distillation data were used in conjunction with API correlations to calculate a large number of shale oil properties that are required for computer models such as ASPEN. The experimental determination of many of the shale oil properties was beyond the scope of this study. Therefore, direct comparison between calculated and measured values of many properties could not be made. However, molecular weights of the shale oils were measured. In this case, there was poor agreement between measured molecular weights and those calculated from API and other published correlations. 23 refs., 12 figs., 15 tabs.

  12. Virtual Reference, Real Money: Modeling Costs in Virtual Reference Services

    ERIC Educational Resources Information Center

    Eakin, Lori; Pomerantz, Jeffrey

    2009-01-01

    Libraries nationwide are in yet another phase of belt tightening. Without an understanding of the economic factors that influence library operations, however, controlling costs and performing cost-benefit analyses on services is difficult. This paper describes a project to develop a cost model for collaborative virtual reference services. This…

  13. Swahili Learners' Reference Grammar. African Language Learners' Reference Grammar Series.

    ERIC Educational Resources Information Center

    Thompson, Katrina Daly; Schleicher, Antonia Folarin

    This reference grammar is written for speakers of English who are learning Swahili. Because many language learners are not familiar with the grammatical terminology, this book explains the basic terminology and concepts of English grammar that are necessary for understanding the grammar of Swahili. It assumes no formal knowledge of English grammar…

  14. A Closer Look at the Thresholds of Thermal Damage: Workshop Report by an ICNIRP Task Group.

    PubMed

    Sienkiewicz, Zenon; van Rongen, Eric; Croft, Rodney; Ziegelberger, Gunde; Veyret, Bernard

    2016-09-01

    The International Commission on Non-Ionizing Radiation Protection issued guidelines in 1998 for limiting public and occupational exposure to radiofrequency electromagnetic fields (100 kHz to 300 GHz). As part of the process of updating this advice, a 2-d workshop titled "A closer look at the thresholds of thermal damage" was held from 26-28 May 2015 in Istanbul to re-examine the thermal basis of the guidelines and to provide further information on heat-related effects and thresholds of thermal damage. Overall, the workshop provided much useful information relevant to revision of the guidelines. Participants indicated that the effects of heating from radiofrequency fields are consistent with those from other sources, and that the information derived from those studies can be applied to radiofrequency-induced heating. Another conclusion was that absolute temperature of tissues was more important for thermal damage than temperature change. The discussion suggested that the 6-min averaging time used in international guidelines was valid for whole-body exposures but with a large uncertainty: 30 min may be a more appropriate averaging time for localized exposures, and less than 1 min for implanted medical devices. The duration of whole-body radiofrequency exposure is a critical parameter that often determines the effect threshold, but this will be affected by other, ongoing thermoregulation, which is dependant on many factors. The thresholds for localized radiofrequency exposure were difficult to determine because of the potential range of exposure conditions and the possibility of radiofrequency-induced local hotspots. Suggestions for future dose metrics and further research were discussed and are included in this report. PMID:27472755

  15. A Closer Look at the Thresholds of Thermal Damage: Workshop Report by an ICNIRP Task Group

    PubMed Central

    Sienkiewicz, Zenon; van Rongen, Eric; Croft, Rodney; Ziegelberger, Gunde; Veyret, Bernard

    2016-01-01

    Abstract The International Commission on Non-Ionizing Radiation Protection issued guidelines in 1998 for limiting public and occupational exposure to radiofrequency electromagnetic fields (100 kHz to 300 GHz). As part of the process of updating this advice, a 2‐d workshop titled “A closer look at the thresholds of thermal damage” was held from 26–28 May 2015 in Istanbul to re-examine the thermal basis of the guidelines and to provide further information on heat-related effects and thresholds of thermal damage. Overall, the workshop provided much useful information relevant to revision of the guidelines. Participants indicated that the effects of heating from radiofrequency fields are consistent with those from other sources, and that the information derived from those studies can be applied to radiofrequency-induced heating. Another conclusion was that absolute temperature of tissues was more important for thermal damage than temperature change. The discussion suggested that the 6‐min averaging time used in international guidelines was valid for whole-body exposures but with a large uncertainty: 30 min may be a more appropriate averaging time for localized exposures, and less than 1 min for implanted medical devices. The duration of whole-body radiofrequency exposure is a critical parameter that often determines the effect threshold, but this will be affected by other, ongoing thermoregulation, which is dependant on many factors. The thresholds for localized radiofrequency exposure were difficult to determine because of the potential range of exposure conditions and the possibility of radiofrequency-induced local hotspots. Suggestions for future dose metrics and further research were discussed and are included in this report. PMID:27472755

  16. Dietary reference intakes: cases of appropriate and inappropriate uses.

    PubMed

    Trumbo, Paula R; Barr, Susan I; Murphy, Suzanne P; Yates, Allison A

    2013-10-01

    The dietary reference intakes (DRIs) are a set of reference intake levels for nutrients that can be used for planning diets and assessing nutrient inadequacies of individuals and groups. Since the publication of the DRI reports 1997-2004, the reference intake levels have been used for various purposes. While DRIs have been used appropriately for planning and assessing diets for many different situations, there have been instances in which specific DRI categories have not been applied as intended. In this review, cases are described in which DRIs were applied correctly, as well as cases from the growing number of examples in which the wrong DRI was used or DRIs were used incorrectly.

  17. Fetal exposure to low frequency electric and magnetic fields

    NASA Astrophysics Data System (ADS)

    Cech, R.; Leitgeb, N.; Pediaditis, M.

    2007-02-01

    To investigate the interaction of low frequency electric and magnetic fields with pregnant women and in particular with the fetus, an anatomical voxel model of an 89 kg woman at week 30 of pregnancy was developed. Intracorporal electric current density distributions due to exposure to homogeneous 50 Hz electric and magnetic fields were calculated and results were compared with basic restrictions recommended by ICNIRP guidelines. It could be shown that the basic restriction is met within the central nervous system (CNS) of the mother at exposure to reference level of either electric or magnetic fields. However, within the fetus the basic restriction is considerably exceeded. Revision of reference levels might be necessary.

  18. Reference standards for software evaluation.

    PubMed

    Michaelis, J; Wellek, S; Willems, J L

    1990-09-01

    The field of automated ECG analysis was one of the earliest topics in Medical Informatics and may be regarded as a model both for computer-assisted medical diagnosis and for evaluating medical diagnostic programs. The CSE project has set reference standards of two kinds: In a broad sense, a standard how to perform a comprehensive evaluation study, in a narrow sense, standards as specific references for evaluating computer ECG programs. The evaluation methodology used within the CSE project is described as a basis for presentation of results which are published elsewhere in this issue. PMID:2233375

  19. When Is Cataphoric Reference Recognised?

    ERIC Educational Resources Information Center

    Filik, Ruth; Sanford, Anthony J.

    2008-01-01

    Pronouns typically have explicit antecedents in the prior discourse otherwise processing difficulty is experienced. However, it has been argued [Gordon, P. C., & Hendrick, R. (1997). "Intuitive knowledge of linguistic co-reference." "Cognition, 62", 325-370; Gordon, P. C., & Hendrick, R. (1998). "The representation and processing of co-reference…

  20. Selected Reference Books of 1998.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1999-01-01

    Reviews a selection of recent scholarly and general reference works under the categories of Periodicals and Newspapers, Philosophy, Literature, Film and Radio, Art and Architecture, Music, Political Science, Women's Studies, and History. A brief summary of new editions of standard works is provided at the end of the articles. (AEF)

  1. Selected Reference Books of 2000.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    2001-01-01

    This annotated bibliography, a semiannual series, presents a selection of recent scholarly and general reference works, published in 2000. Works are in the following areas: dictionaries; religion; literature; film; music; political science; history; archaeology; and science and technology. New editions of standard works are highlighted at the end.…

  2. Selected Reference Books of 1997.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1998-01-01

    Reviews a selection of recent scholarly and general reference works under the categories of Book Reviews, Proverbs, Literature, Archives, Social Sciences, Women's Studies, History and Area Studies, and Sciences. A brief summary of new editions of standard works is provided at the end of the articles. (AEF)

  3. Bibliographies, Reference Works, and Archives.

    ERIC Educational Resources Information Center

    Elliott, Clark A.

    1985-01-01

    Explores the history of science in America from the viewpoint of access to sources. Considered are a number of specific bibliographic and other reference works, as well as important recent projects and developments that aim to preserve and improve access to archival and other documentation and historical data for future use. (JN)

  4. Manitoba. Reference Series No. 28.

    ERIC Educational Resources Information Center

    Department of External Affairs, Ottawa (Ontario).

    This booklet, one of a series featuring the Canadian provinces, presents a brief overview of Manitoba and is suitable for teacher reference or student reading. Separate sections discuss agriculture, mining, energy, transportation and communication, fishing, forestry, fur trapping, health and social services, education, and political life. Specific…

  5. The Principal and Reference Letters.

    ERIC Educational Resources Information Center

    Smith, Agnes E.; Permuth, Steve; Gray, David L.

    1999-01-01

    Requests to write letters of reference for former teachers can be legally problematic. Principals should know relevant state laws; have employees sign a release from liability; provide only factual information; maintain fair personnel files; avoid telephone recommendations; disclose information on a need-to-know basis; and avoid performance…

  6. Usenet as a Reference Tool.

    ERIC Educational Resources Information Center

    Klassen, Tim W.

    1995-01-01

    Describes Usenet, an Internet service that provides access to computerized discussion groups, and examines how it can be used as a reference tool. Topics include subject groups, appropriate questions, exhausting local resources before posting, explaining Usenet to patrons, sending the question, and evaluating the answer. (AEF)

  7. Criminal Justice - Selected Reference Materials.

    ERIC Educational Resources Information Center

    McClure, John D., III, Comp.

    This bibliography reviews approximately 70 reference materials on criminal justice. Entries are presented in eight categories--dictionaries, indexes and abstracts, professional position papers, working conditions and unions, law and the police, crime, prisons and prisoners, and victimization. Types of publications included under the subject…

  8. Human Rights: The Essential Reference.

    ERIC Educational Resources Information Center

    Devine, Carol; Hansen, Carol Rae; Wilde, Ralph; Bronkhorst, Daan; Moritz, Frederic A.; Rolle, Baptiste; Sherman, Rebecca; Southard, Jo Lynn; Wilkinson, Robert; Poole, Hilary, Ed.

    This reference work documents the history of human rights theory, explains each article of the Universal Declaration of Human Rights, explores the contemporary human rights movement, and examines the major human rights issues facing the world today. This book is the first to combine historical and contemporary perspectives on these critical…

  9. Quebec. Reference Series No. 30.

    ERIC Educational Resources Information Center

    Department of External Affairs, Ottawa (Ontario).

    This booklet, one of a series featuring the Canadian provinces, presents a brief overview of Quebec and is suitable for teacher reference or student reading. Separate sections discuss geography, climate, population, history, political history, recent politics, agriculture, forestry, mining, manufacturing and industry, hydroelectric power,…

  10. Tractor Transmissions. A Teaching Reference.

    ERIC Educational Resources Information Center

    American Association for Agricultural Engineering and Vocational Agriculture, Athens, GA.

    The manual was developed as a reference for teaching students about transmissions in farm tractors. The manual is divided into five sections: (1) transmission history, (2) gears and bearings in transmission, (3) sliding-gear transmissions, (4) planetary gearing, and (5) glossary. The working principles of the sliding-gear transmission, the most…

  11. Alberta. Reference Series No. 26.

    ERIC Educational Resources Information Center

    Department of External Affairs, Ottawa (Ontario).

    This booklet, one of a series featuring the Canadian provinces, presents a brief overview of Alberta and is suitable for teacher reference or student reading. Separate sections discuss the history and population, the provincial government, the economy, transportation, communications, mineral resources, agriculture, manufacturing, forest products,…

  12. Space Station reference configuration update

    NASA Technical Reports Server (NTRS)

    Bonner, Tom F., Jr.

    1985-01-01

    The reference configuration of the NASA Space Station as of November 1985 is presented in a series of diagrams, drawings, graphs, and tables. The configurations for components to be contributed by ESA, Canada, and Japan are included. Brief captions are provided, along with answers to questions raised at the conference.

  13. Selected Reference Books of 1992.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1993-01-01

    Presents an annotated bibliography of 40 recent scholarly and general works of interest to reference workers in university libraries. Topics areas covered include philosophy, religion, language, literature, architecture, economics, law, area studies, Russia and the Soviet Union, women's studies, and Christopher Columbus. New editions and…

  14. Selected Reference Books of 1996.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1997-01-01

    Presents an annotated list of recent scholarly and general reference books as compiled by Columbia University libraries. Subject categories include religion, literature, women's studies, film studies, art and architecture, political science, history and area studies, technology, and new editions and supplements. (LRW)

  15. Measurement at the Reference Desk.

    ERIC Educational Resources Information Center

    White, Howard D.

    1981-01-01

    Proposes using the Statistical Package for the Social Sciences (SPSS) for the analysis of routine library statistics to measure how well certain goals are being reached and discusses variables and procedures that might be used. Information on SPSS, sample selection, and Yule's Q analysis is appended, and 18 references are listed. (RAA)

  16. Childhood Obesity. Special Reference Briefs.

    ERIC Educational Resources Information Center

    Winick, Myron

    This reference brief deals with the problem of childhood obesity and how it can lead to obesity in the adult. Eighty-four abstracts are presented of studies on the identification, prevention, and treatment of obesity in children, focusing on diet and psychological attitudes. Subjects of the studies were children ranging in age from infancy through…

  17. Reference As Others Do It.

    ERIC Educational Resources Information Center

    Coffman, Steve

    1999-01-01

    Describes customer call centers that provide customer service and support in business and considers how their routines could be adapted to library operations. Topics include centralized staff; interactive voice response; automated call distribution; question analysis; sophisticated software; training and monitoring; telephone reference; and…

  18. Expert Systems in Reference Services.

    ERIC Educational Resources Information Center

    Roysdon, Christine, Ed.; White, Howard D., Ed.

    1989-01-01

    Eleven articles introduce expert systems applications in library and information science, and present design and implementation issues of system development for reference services. Topics covered include knowledge based systems, prototype development, the use of artificial intelligence to remedy current system inadequacies, and an expert system to…

  19. Ontario. Reference Series No. 29.

    ERIC Educational Resources Information Center

    Department of External Affairs, Ottawa (Ontario).

    This booklet, one of a series featuring the Canadian provinces, presents a brief overview of Ontario and is suitable for teacher reference or student reading. Separate sections discuss geography, climate, history, agriculture, forestry, fishing, mining, manufacturing, transportation, energy, arts and culture, sports and recreation, and people and…

  20. Chapter 11: Dietary reference intakes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Dietary Reference Intakes (DRI) are a set of recommendations intended to provide guidance in evaluating nutrient intakes and planning meals on the basis of nutrient adequacy. In contrast to their predecessor, Recommended Dietary Allowances last published in 1989, the DRIs differ in two ways: th...

  1. A REFERENCE GRAMMAR OF PANJABI.

    ERIC Educational Resources Information Center

    GILL, HARJEET S.; GLEASON, HENRY A., JR.

    A REFERENCE GRAMMAR WAS PREPARED FOR STUDENTS OF PANJABI. THE INTENTION OF THE COMPILERS WAS TO MAKE IT USEFUL TO THOSE PREPARING TEACHING MATERIALS FOR PANJABI, THOSE TEACHING THE LANGUAGE BY MODERN AURAL-LINGUAL METHODS, OR OTHER USERS (NOT NECESSARILY PROFESSIONAL LINGUISTS) WHO WISH A DESCRIPTION BASED EQUALLY ON THE SPOKEN AND THE WRITTEN…

  2. [Developmental Placement.] Collected Research References.

    ERIC Educational Resources Information Center

    Bjorklund, Gail

    Drawing on information and references in the ERIC system, this literature review describes research related to a child's developmental placement. The issues examined include school entrance age; predictive validity, reliability, and features of Gesell School Readiness Assessment; retention; and the effectiveness of developmental placement. A…

  3. Mobile Technologies and Roving Reference

    ERIC Educational Resources Information Center

    Penner, Katherine

    2011-01-01

    As 21st century librarians, we have made apt adjustments for reaching out into the digital world, but we need to consider the students who still use library services within our walls. We can use available handheld, mobile technologies to help patrons too shy to approach the desk and free library staff to bring reference service directly to patrons.

  4. Saskatchewan. Reference Series No. 27.

    ERIC Educational Resources Information Center

    Department of External Affairs, Ottawa (Ontario).

    This booklet, one of a series featuring the Canadian provinces, presents a brief overview of Saskatchewan and is suitable for teacher reference or student reading. Separate sections discuss history, economy, oil, uranium, potash, coal, minerals and metals, agriculture, forestry, tourism and recreation, arts and culture, and people. Specific topics…

  5. Newfoundland. Reference Series No. 34.

    ERIC Educational Resources Information Center

    Department of External Affairs, Ottawa (Ontario).

    This booklet, one of a series featuring the Canadian provinces, presents a brief overview of Newfoundland and is suitable for teacher reference or student reading. Separate sections discuss geography and climate, history, economy, population and settlement, arts and culture, leisure and recreation, and heritage. Specific topics include the…

  6. Guam and Micronesia Reference Sources.

    ERIC Educational Resources Information Center

    Goetzfridt, Nicholas J.; Goniwiecha, Mark C.

    1993-01-01

    This article lists reference sources for studying Guam and Micronesia. The entries are arranged alphabetically by main entry within each section in the categories of: (1) bibliographical works; (2) travel and guide books; (3) handbooks and surveys; (4) dictionaries; (5) yearbooks; (6) periodical and newspaper publications; and (7) audiovisual…

  7. Dispersion analysis for baseline reference mission 2

    NASA Technical Reports Server (NTRS)

    Snow, L. S.

    1975-01-01

    A dispersion analysis considering uncertainties (or perturbations) in platform, vehicle, and environmental parameters was performed for baseline reference mission (BRM) 2. The dispersion analysis is based on the nominal trajectory for BRM 2. The analysis was performed to determine state vector and performance dispersions (or variations) which result from the indicated uncertainties. The dispersions are determined at major mission events and fixed times from liftoff (time slices). The dispersion results will be used to evaluate the capability of the vehicle to perform the mission within a specified level of confidence and to determine flight performance reserves.

  8. Locating and parsing bibliographic references in HTML medical articles

    PubMed Central

    Zou, Jie; Le, Daniel; Thoma, George R.

    2010-01-01

    The set of references that typically appear toward the end of journal articles is sometimes, though not always, a field in bibliographic (citation) databases. But even if references do not constitute such a field, they can be useful as a preprocessing step in the automated extraction of other bibliographic data from articles, as well as in computer-assisted indexing of articles. Automation in data extraction and indexing to minimize human labor is key to the affordable creation and maintenance of large bibliographic databases. Extracting the components of references, such as author names, article title, journal name, publication date and other entities, is therefore a valuable and sometimes necessary task. This paper describes a two-step process using statistical machine learning algorithms, to first locate the references in HTML medical articles and then to parse them. Reference locating identifies the reference section in an article and then decomposes it into individual references. We formulate this step as a two-class classification problem based on text and geometric features. An evaluation conducted on 500 articles drawn from 100 medical journals achieves near-perfect precision and recall rates for locating references. Reference parsing identifies the components of each reference. For this second step, we implement and compare two algorithms. One relies on sequence statistics and trains a Conditional Random Field. The other focuses on local feature statistics and trains a Support Vector Machine to classify each individual word, followed by a search algorithm that systematically corrects low confidence labels if the label sequence violates a set of predefined rules. The overall performance of these two reference-parsing algorithms is about the same: above 99% accuracy at the word level, and over 97% accuracy at the chunk level. PMID:20640222

  9. Locating and parsing bibliographic references in HTML medical articles.

    PubMed

    Zou, Jie; Le, Daniel; Thoma, George R

    2010-06-01

    The set of references that typically appear toward the end of journal articles is sometimes, though not always, a field in bibliographic (citation) databases. But even if references do not constitute such a field, they can be useful as a preprocessing step in the automated extraction of other bibliographic data from articles, as well as in computer-assisted indexing of articles. Automation in data extraction and indexing to minimize human labor is key to the affordable creation and maintenance of large bibliographic databases. Extracting the components of references, such as author names, article title, journal name, publication date and other entities, is therefore a valuable and sometimes necessary task. This paper describes a two-step process using statistical machine learning algorithms, to first locate the references in HTML medical articles and then to parse them. Reference locating identifies the reference section in an article and then decomposes it into individual references. We formulate this step as a two-class classification problem based on text and geometric features. An evaluation conducted on 500 articles drawn from 100 medical journals achieves near-perfect precision and recall rates for locating references. Reference parsing identifies the components of each reference. For this second step, we implement and compare two algorithms. One relies on sequence statistics and trains a Conditional Random Field. The other focuses on local feature statistics and trains a Support Vector Machine to classify each individual word, followed by a search algorithm that systematically corrects low confidence labels if the label sequence violates a set of predefined rules. The overall performance of these two reference-parsing algorithms is about the same: above 99% accuracy at the word level, and over 97% accuracy at the chunk level.

  10. New Reference Values for Vitamin C Intake.

    PubMed

    2015-01-01

    The German, Austrian, and Swiss nutrition societies are the editors of the 'reference values for nutrient intake'. They have revised the reference values for the intake of vitamin C and published them in February 2015. The average vitamin C requirement in healthy adults is considered to be the vitamin C amount that compensates for the metabolic losses of vitamin C, and ensures a fasting ascorbate plasma level of 50 µmol/l. Based on the present data from studies with non-smoking men, metabolic losses of 50 mg/day are assumed, as well as an absorption rate of 80% and an urinary excretion of 25% of the vitamin C intake. Taking this into account, the calculated average requirement in men is 91 mg/day. Considering a coefficient of variation of 10%, a reference value (recommended intake) of 110 mg/day for men is derived. The vitamin C requirement in women as well as in children and adolescents is extrapolated from the requirement in men and in relation to their body weight. This results in a recommended intake of about 95 mg/day for adult women. Because the requirement in pregnant and lactating women is increased, higher recommended intakes are derived for them, 105 mg/day for pregnant women from the fourth month on and 125 mg/day for lactating women, respectively. For boys and girls at the age of 1 to under 15 years, there are increasing recommended intake values from 20 to 85 mg/day. For male and female adolescents, at the age of 15 to under 19 years, the recommended intake is 105 and 90 mg, respectively. As smokers have higher metabolic losses and lower plasma levels of vitamin C than non-smokers (turnover is 40% higher), the reference value for vitamin C intake is set to 135 mg/day for female smokers and 155 mg/day for male smokers. For infants in their first year of life, the reference value (estimated value) is set to 20 mg vitamin C/ day, based upon the lowest observed vitamin C intake for infants in the United Kingdom and the United States, that obviously meets

  11. Genetics Home Reference: aromatase deficiency

    MedlinePlus

    ... by reduced levels of the female sex hormone estrogen and increased levels of the male sex hormone ... in male sexual development, to different forms of estrogen. In females, estrogen guides female sexual development before ...

  12. Reference Material for Seebeck Coefficients

    NASA Astrophysics Data System (ADS)

    Edler, F.; Lenz, E.; Haupt, S.

    2015-03-01

    This paper describes a measurement method and a measuring system to determine absolute Seebeck coefficients of thermoelectric bulk materials with the aim of establishing reference materials for Seebeck coefficients. Reference materials with known thermoelectric properties are essential to allow a reliable benchmarking of different thermoelectric materials for application in thermoelectric generators to convert thermal into electrical energy or vice versa. A temperature gradient (1 to 8) K is induced across the sample, and the resulting voltage is measured by using two differential Au/Pt thermocouples. On the basis of the known absolute Seebeck coefficients of Au and Pt, the unknown Seebeck coefficient of the sample is calculated. The measurements are performed in inert atmospheres and at low pressure (30 to 60) mbar in the temperature range between 300 K and 860 K. The measurement results of the Seebeck coefficients of metallic and semiconducting samples are presented. Achievable relative measurement uncertainties of the Seebeck coefficient are on the order of a few percent.

  13. Developing a quick reference formulary.

    PubMed

    Huntzinger, P E

    2001-10-01

    The establishment of the Department of Defense Basic Core Formulary was an attempt by the Department of Defense to equilibrate its pharmacy benefit among military treatment facilities. Department of Defense military treatment facilities are required to make available to beneficiaries items on the Basic Core Formulary. Military treatment facilities may augment the Basic Core Formulary through local pharmacy and therapeutic committee actions that result in different formularies among military treatment facilities. Formulary differences among military treatment facilities also arise because the Coast Guard, which is under the jurisdiction of the Department of Transportation in peacetime, is not required to adhere to the Basic Core Formulary at present. Because of formulary differences, most military treatment facilities make available abbreviated, quick reference versions of their formularies to patients. This article describes the development of a quick reference formulary at a Coast Guard military treatment facility pharmacy.

  14. The Calibration Reference Data System

    NASA Astrophysics Data System (ADS)

    Greenfield, P.; Miller, T.

    2016-07-01

    We describe a software architecture and implementation for using rules to determine which calibration files are appropriate for calibrating a given observation. This new system, the Calibration Reference Data System (CRDS), replaces what had been previously used for the Hubble Space Telescope (HST) calibration pipelines, the Calibration Database System (CDBS). CRDS will be used for the James Webb Space Telescope (JWST) calibration pipelines, and is currently being used for HST calibration pipelines. CRDS can be easily generalized for use in similar applications that need a rules-based system for selecting the appropriate item for a given dataset; we give some examples of such generalizations that will likely be used for JWST. The core functionality of the Calibration Reference Data System is available under an Open Source license. CRDS is briefly contrasted with a sampling of other similar systems used at other observatories.

  15. The International Celestial Reference System

    NASA Astrophysics Data System (ADS)

    Fomalont, E.

    2016-05-01

    The International Celestial Reference System (ICRS) is a set of prescriptions, conventions, observational techniques and modeling required to define an celestial inertial frame. The origin of the frame is the solar-system barycenter. The ICRS was adopted by the International Astronomical Union in 1997 as the replacement of the FK5 system. The frame is called the International Celestial Reference Frame (ICRF), and is realized (defined) by the accurate position of 295 radio sources, distributed over the sky, and the accuracy of the frame orientation is about 10 microarcsec. This review will cover: the history of the development of the ICRS; the basics of the major observational technique of Very Long Baseline Interferometry; the use of the fundamental observable, the group delay; experimental strategies to optimize the accuracy; the computational methods for analyzing the large data base; the two major error limitations; and the possible of ICRS/Gaia interactions.

  16. Circuit and method for producing a flexible reference voltage

    NASA Technical Reports Server (NTRS)

    Thornton, Roger D. (Inventor)

    1993-01-01

    A flexible reference voltage circuit includes a circuit for producing a first digital signal representative of a range of reference voltage levels; a circuit for producing a second digital signal representative of a selected reference voltage level within the range of reference voltage levels; an adder for adding the first and second digital signals to produce a third digital signal; and a digital to analog converter for providing an output voltage in response to the third digital signal. The method of producing a flexible reference voltage performed by the circuit is also claimed. The invention can be used with a differential protection circuit to provide a series of trip level ranges, with a series of selectable trip levels in each range. This is accomplished in a high accuracy circuit which is relatively simple to construct, thereby minimizing size and complexity of the current sensor module, in differential protection applications, or the circuitry, if used in a power system controller. Standard digital logic components can be used to perform the necessary range/level decoding.

  17. National Software Reference Library (NSRL)

    National Institute of Standards and Technology Data Gateway

    National Software Reference Library (NSRL) (PC database for purchase)   A collaboration of the National Institute of Standards and Technology (NIST), the National Institute of Justice (NIJ), the Federal Bureau of Investigation (FBI), the Defense Computer Forensics Laboratory (DCFL),the U.S. Customs Service, software vendors, and state and local law enforement organizations, the NSRL is a tool to assist in fighting crime involving computers.

  18. HANFORD WASTE MINERALOGY REFERENCE REPORT

    SciTech Connect

    DISSELKAMP RS

    2010-06-29

    This report lists the observed mineral phases present in the Hanford tanks. This task was accomplished by performing a review of numerous reports that used experimental techniques including, but not limited to: x-ray diffraction, polarized light microscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, electron energy loss spectroscopy, and particle size distribution analyses. This report contains tables that can be used as a quick reference to identify the crystal phases observed in Hanford waste.

  19. HANFORD WASTE MINEROLOGY REFERENCE REPORT

    SciTech Connect

    DISSELKAMP RS

    2010-06-18

    This report lists the observed mineral phase phases present in the Hanford tanks. This task was accomplished by performing a review of numerous reports using experimental techniques including, but not limited to: x-ray diffraction, polarized light microscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, electron energy loss spectroscopy, and particle size distribution analyses. This report contains tables that can be used as a quick reference to identify the crystal phases present observed in Hanford waste.

  20. Levels at gaging stations

    USGS Publications Warehouse

    Kenney, Terry A.

    2010-01-01

    Operational procedures at U.S. Geological Survey gaging stations include periodic leveling checks to ensure that gages are accurately set to the established gage datum. Differential leveling techniques are used to determine elevations for reference marks, reference points, all gages, and the water surface. The techniques presented in this manual provide guidance on instruments and methods that ensure gaging-station levels are run to both a high precision and accuracy. Levels are run at gaging stations whenever differences in gage readings are unresolved, stations may have been damaged, or according to a pre-determined frequency. Engineer's levels, both optical levels and electronic digital levels, are commonly used for gaging-station levels. Collimation tests should be run at least once a week for any week that levels are run, and the absolute value of the collimation error cannot exceed 0.003 foot/100 feet (ft). An acceptable set of gaging-station levels consists of a minimum of two foresights, each from a different instrument height, taken on at least two independent reference marks, all reference points, all gages, and the water surface. The initial instrument height is determined from another independent reference mark, known as the origin, or base reference mark. The absolute value of the closure error of a leveling circuit must be less than or equal to ft, where n is the total number of instrument setups, and may not exceed |0.015| ft regardless of the number of instrument setups. Closure error for a leveling circuit is distributed by instrument setup and adjusted elevations are determined. Side shots in a level circuit are assessed by examining the differences between the adjusted first and second elevations for each objective point in the circuit. The absolute value of these differences must be less than or equal to 0.005 ft. Final elevations for objective points are determined by averaging the valid adjusted first and second elevations. If final elevations

  1. Genetic relatedness of Trichomonas vaginalis reference and clinical isolates.

    PubMed

    Cornelius, Denise C; Mena, Leandro; Lushbaugh, William B; Meade, John C

    2010-12-01

    We have determined the metronidazole susceptibility status of 20 Trichomonas vaginalis isolates from American Type Culture Collection (ATCC) and assessed the level of genetic relatedness in these isolates using 32 additional T. vaginalis clinical isolates for comparison. These ATCC isolates are commonly used as reference strains in T. vaginalis research and this information provides a rational basis for selection of reference strains for use in comparative studies of T. vaginalis phenotypic and clinical characteristics. PMID:21118935

  2. The Neurobiology of Reference-Dependent Value Computation

    PubMed Central

    De Martino, Benedetto; Kumaran, Dharshan; Holt, Beatrice; Dolan, Raymond J.

    2009-01-01

    A key focus of current research in neuroeconomics concerns how the human brain computes value. Although, value has generally been viewed as an absolute measure (e.g., expected value, reward magnitude), much evidence suggests that value is more often computed with respect to a changing reference point, rather than in isolation. Here, we present the results of a study aimed to dissociate brain regions involved in reference-independent (i.e., “absolute”) value computations, from those involved in value computations relative to a reference point. During functional magnetic resonance imaging, subjects acted as buyers and sellers during a market exchange of lottery tickets. At a behavioral level, we demonstrate that subjects systematically accorded a higher value to objects they owned relative to those they did not, an effect that results from a shift in reference point (i.e., status quo bias or endowment effect). Our results show that activity in orbitofrontal cortex and dorsal striatum track parameters such as the expected value of lottery tickets indicating the computation of reference-independent value. In contrast, activity in ventral striatum indexed the degree to which stated prices, at a within-subjects and between-subjects level, were distorted with respect to a reference point. The findings speak to the neurobiological underpinnings of reference dependency during real market value computations. PMID:19321780

  3. The role of referent and expert power in mutual help.

    PubMed

    Salem, D A; Reischl, T M; Gallacher, F; Randall, K W

    2000-06-01

    This study explored the roles of referent power (i.e., influence based on sense of identification) and expert power (i.e., influence based on knowledge and expertise) in Schizophrenics Anonymous (SA), a mutual-help group for persons experiencing a schizophrenia-related illness. The study describes SA participants' experience of referent and expert power with SA members, SA leaders, and with mental health professionals. It also examines whether or not referent and expert power ascribed to fellow SA participants predicts the perceived helpfulness of the group. One hundred fifty-six SA participants were surveyed. Participants reported experiencing higher levels of referent power with fellow SA members and leaders than with mental health professionals. They reported higher levels of expert power for mental health professionals and SA leaders than for SA members. The respondents' ratings of their SA group's helpfulness was significantly correlated with ratings of referent and expert power. Although expert power was the best independent predictor of helpfulness, a significant interaction between referent and expert power indicated that when members reported high referent power, expert power was not related to helpfulness. These results are interpreted to suggest that there are multiple forms of social influence at work in mutual help.

  4. Certified reference materials and reference methods for nuclear safeguards and security.

    PubMed

    Jakopič, R; Sturm, M; Kraiem, M; Richter, S; Aregbe, Y

    2013-11-01

    have therefore reached high level of attention for safeguards authorities. Furthermore, IRMM initiated and coordinated the development of a Modified Total Evaporation (MTE) technique for accurate abundance ratio measurements of the "minor" isotope-amount ratios of uranium and plutonium in nuclear material and, in combination with a multi-dynamic measurement technique and filament carburization, in environmental samples. Currently IRMM is engaged in a study on the development of plutonium reference materials for "age dating", i.e. determination of the time elapsed since the last separation of plutonium from its daughter nuclides. The decay of a radioactive parent isotope and the build-up of a corresponding amount of daughter nuclide serve as chronometer to calculate the age of a nuclear material. There are no such certified reference materials available yet. PMID:23507450

  5. PVWatts Version 1 Technical Reference

    SciTech Connect

    Dobos, A. P.

    2013-10-01

    The NREL PVWatts(TM) calculator is a web application developed by the National Renewable Energy Laboratory (NREL) that estimates the electricity production of a grid-connected photovoltaic system based on a few simple inputs. PVWatts combines a number of sub-models to predict overall system performance, and makes several hidden assumptions about performance parameters. This technical reference details the individual sub-models, documents assumptions and hidden parameters, and explains the sequence of calculations that yield the final system performance estimation.

  6. Reference electrode for electrolytic cell

    DOEpatents

    Kessie, R.W.

    1988-07-28

    A reference electrode device is provided for a high temperature electrolytic cell used to electrolytically recover uranium from spent reactor fuel dissolved in an anode pool, the device having a glass tube to enclose the electrode and electrolyte and serve as a conductive membrane with the cell electrolyte, and an outer metal tube about the glass tube to serve as a shield and basket for any glass sections broken by handling of the tube to prevent their contact with the anode pool, the metal tube having perforations to provide access between the bulk of the cell electrolyte and glass membrane. 4 figs.

  7. Electrolytic cell with reference electrode

    DOEpatents

    Kessie, Robert W.

    1989-01-01

    A reference electrode device is provided for a high temperature electrolytic cell used to electrolytically recover uranium from spent reactor fuel dissolved in an anode pool, the device having a glass tube to enclose the electrode and electrolyte and serve as a conductive membrane with the cell electrolyte, and an outer metal tube about the glass tube to serve as a shield and basket for any glass sections broken by handling of the tube to prevent their contact with the anode pool, the metal tube having perforations to provide access between the bulk of the cell electrolyte and glass membrane.

  8. Reference atmospheres: VIRA II -Venus International Reference Atmosphere update.

    NASA Astrophysics Data System (ADS)

    Zasova, Ludmila

    2012-07-01

    VIRA I was started in 1982 (30 years ago) and published in1985 (ASR,v5,n11, 1985) by G. Keating, A. Kliore, and V. Moroz. The purpose was to produce a concise, descriptive model summarizing the physical properties of the atmosphere of Venus, which by then had been extensively observed by instruments on board the Venera and Pioneer space probes. VIRA was used by many scientists and engineers in their studies as referent standard of atmospheric data. Afterwards several missions have obtained new data. In particular the experiments on late Veneras and Venus Express. Experiments on board of VEX, working on the orbit for 6 years, provide new high quality data on atmospheric structure, clouds properties, dynamics, composition of the atmosphere, thermal balance, ionosphere. These new data will be used for VIRA update. Original data consists of 7 Chapters.(1 ) Models of the structure of the atmosphere of Venus from the surface to 100 km altitude, (2) Circulation of the atmosphere from surface to 100 km, (3) Particulate matter in the Venus atmosphere, (4) Models of Venus neutral upper atmosphere: structure and composition, (5) Composition of the atmosphere below 100 km altitude, (6) Solar and thermal radiation in the Venus atmosphere, (7) The Venus ionosphere. By 2002 Gerry Keating collected materials to update VIRA. But only two chapter were published: (1 ) Models of the structure of the atmosphere of Venus from the surface to 100 km altitude (Zasova et al, 2006, Cosmic Research, 44, N4), (5) Composition of the atmosphere below 100 km altitude (De Bergh et al. 2006, PSS). Both these chapters were based on the data, obtained before VEX. At the moment the structure of the original VIRA looks acceptable for VIRA II also, however, new Chapters may be added. At COSPAR 2014 in Moscow the session on Reference atmospheres (RAPS), may be proposed to continue discussion on VIRA, and start working on MIRA, and complete VIRA and publish (including CD) after COSPAR 2016 (or may be even

  9. Reference ballistic imaging database performance.

    PubMed

    De Kinder, Jan; Tulleners, Frederic; Thiebaut, Hugues

    2004-03-10

    Ballistic imaging databases allow law enforcement to link recovered cartridge cases to other crime scenes and to firearms. The success of these databases has led many to propose that all firearms in circulation be entered into a reference ballistic image database (RBID). To assess the performance of an RBID, we fired 4200 cartridge cases from 600 9mm Para Sig Sauer model P226 series pistols. Each pistol fired two Remington cartridges, one of which was imaged in the RBID, and five additional cartridges, consisting of Federal, Speer, Winchester, Wolf, and CCI brands. Randomly selected samples from the second series of Remington cartridge cases and from the five additional brands were then correlated against the RBID. Of the 32 cartridges of the same make correlated against the RBID, 72% ranked in the top 10 positions. Likewise, of the 160 cartridges of the five different brands correlated against the database, 21% ranked in the top 10 positions. Generally, the ranking position increased as the size of the RBID increased. We obtained similar results when we expanded the RBID to include firearms with the same class characteristics for breech face marks, firing pin impressions, and extractor marks. The results of our six queries against the RBID indicate that a reference ballistics image database of new guns is currently fraught with too many difficulties to be an effective and efficient law enforcement tool.

  10. Multipass Steering: A Reference Implementation

    NASA Astrophysics Data System (ADS)

    Hennessey, Michael; Tiefenback, Michael

    2015-10-01

    We introduce a reference implementation of a protocol to compute corrections that bring all beams in one of the CEBAF linear accelerators (linac) to axis, including, with a larger tolerance, the lowest energy pass using measured beam trajectory data. This method relies on linear optics as representation of the system; we treat beamline perturbations as magnetic field errors localized to regions between cryomodules, providing the same transverse momentum kick to each beam. We produce a vector of measured beam position data with which we left-multiply the pseudo-inverse of a coefficient array, A, that describes the transport of the beam through the linac using parameters that include the magnetic offsets of the quadrupole magnets, the instrumental offsets of the BPMs, and the beam initial conditions. This process is repeated using a reduced array to produce values that can be applied to the available correcting magnets and beam initial conditions. We show that this method is effective in steering the beam to a straight axis along the linac by using our values in elegant, the accelerator simulation program, on a model of the linac in question. The algorithms in this reference implementation provide a tool for systematic diagnosis and cataloging of perturbations in the beam line. Supported by Jefferson Lab, Old Dominion University, NSF, DOE.

  11. New SCIAMACHY Solar Reference Spectrum

    NASA Astrophysics Data System (ADS)

    Hilbig, Tina; Bramstedt, Klaus; Weber, Mark; Burrows, John P.

    2016-04-01

    The Scanning Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY) aboard ESA's ENVISAT satellite platform was operating from 2002 until 2012. It was designed to measure the radiance backscattered from the Earth and hence determine total columns and vertical profiles of atmospheric trace gas species. Furthermore SCIAMACHY performed daily sun observations via a diffuser. Solar spectra in the wavelength range from 212 nm to 1760 nm and two narrow bands from 1930 to 2040 nm and 2260 to 2380 nm are measured with a spectral resolution of 0,2 to 1,5 nm in the different channels. Recent developments in the SCIAMACHY calibration (e.g. a physical model of the scanner unit including degradation effects, and an on-ground to in-flight correction using the on-board white light source (WLS)) are used for the generation of a new SCIAMACHY solar reference spectrum as a first step towards a 10 years time series of solar spectral irradiance (SSI) data. For validation comparisons with other solar reference spectra are performed.

  12. High stability wavefront reference source

    DOEpatents

    Feldman, Mark; Mockler, Daniel J.

    1994-01-01

    A thermally and mechanically stable wavefront reference source which produces a collimated output laser beam. The output beam comprises substantially planar reference wavefronts which are useful for aligning and testing optical interferometers. The invention receives coherent radiation from an input optical fiber, directs a diverging input beam of the coherent radiation to a beam folding mirror (to produce a reflected diverging beam), and collimates the reflected diverging beam using a collimating lens. In a class of preferred embodiments, the invention includes a thermally and mechanically stable frame comprising rod members connected between a front end plate and a back end plate. The beam folding mirror is mounted on the back end plate, and the collimating lens mounted to the rods between the end plates. The end plates and rods are preferably made of thermally stable metal alloy. Preferably, the input optical fiber is a single mode fiber coupled to an input end of a second single mode optical fiber that is wound around a mandrel fixedly attached to the frame of the apparatus. The output end of the second fiber is cleaved so as to be optically flat, so that the input beam emerging therefrom is a nearly perfect diverging spherical wave.

  13. High stability wavefront reference source

    DOEpatents

    Feldman, M.; Mockler, D.J.

    1994-05-03

    A thermally and mechanically stable wavefront reference source which produces a collimated output laser beam is disclosed. The output beam comprises substantially planar reference wavefronts which are useful for aligning and testing optical interferometers. The invention receives coherent radiation from an input optical fiber, directs a diverging input beam of the coherent radiation to a beam folding mirror (to produce a reflected diverging beam), and collimates the reflected diverging beam using a collimating lens. In a class of preferred embodiments, the invention includes a thermally and mechanically stable frame comprising rod members connected between a front end plate and a back end plate. The beam folding mirror is mounted on the back end plate, and the collimating lens mounted to the rods between the end plates. The end plates and rods are preferably made of thermally stable metal alloy. Preferably, the input optical fiber is a single mode fiber coupled to an input end of a second single mode optical fiber that is wound around a mandrel fixedly attached to the frame of the apparatus. The output end of the second fiber is cleaved so as to be optically flat, so that the input beam emerging therefrom is a nearly perfect diverging spherical wave. 7 figures.

  14. 33 CFR 183.210 - Reference areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Reference areas. 183.210 Section... of More Than 2 Horsepower General § 183.210 Reference areas. (a) The forward reference area of a boat...) The aft reference area of a boat is the aft most two feet of the top surface of the hull or deck,...

  15. 33 CFR 183.310 - Reference areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Reference areas. 183.310 Section... of 2 Horsepower or Less General § 183.310 Reference areas. (a) The forward reference area of a boat... aft reference area of a boat is the aftmost two feet of the top surface of the hull or deck,...

  16. 33 CFR 183.310 - Reference areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Reference areas. 183.310 Section... of 2 Horsepower or Less General § 183.310 Reference areas. (a) The forward reference area of a boat... aft reference area of a boat is the aftmost two feet of the top surface of the hull or deck,...

  17. 33 CFR 183.210 - Reference areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Reference areas. 183.210 Section... of More Than 2 Horsepower General § 183.210 Reference areas. (a) The forward reference area of a boat...) The aft reference area of a boat is the aft most two feet of the top surface of the hull or deck,...

  18. 33 CFR 183.310 - Reference areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Reference areas. 183.310 Section... of 2 Horsepower or Less General § 183.310 Reference areas. (a) The forward reference area of a boat... aft reference area of a boat is the aftmost two feet of the top surface of the hull or deck,...

  19. 33 CFR 183.210 - Reference areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Reference areas. 183.210 Section... of More Than 2 Horsepower General § 183.210 Reference areas. (a) The forward reference area of a boat...) The aft reference area of a boat is the aft most two feet of the top surface of the hull or deck,...

  20. 33 CFR 183.310 - Reference areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Reference areas. 183.310 Section... of 2 Horsepower or Less General § 183.310 Reference areas. (a) The forward reference area of a boat... aft reference area of a boat is the aftmost two feet of the top surface of the hull or deck,...

  1. 33 CFR 183.210 - Reference areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Reference areas. 183.210 Section... of More Than 2 Horsepower General § 183.210 Reference areas. (a) The forward reference area of a boat...) The aft reference area of a boat is the aft most two feet of the top surface of the hull or deck,...

  2. 33 CFR 183.210 - Reference areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Reference areas. 183.210 Section... of More Than 2 Horsepower General § 183.210 Reference areas. (a) The forward reference area of a boat...) The aft reference area of a boat is the aft most two feet of the top surface of the hull or deck,...

  3. 33 CFR 183.310 - Reference areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Reference areas. 183.310 Section... of 2 Horsepower or Less General § 183.310 Reference areas. (a) The forward reference area of a boat... aft reference area of a boat is the aftmost two feet of the top surface of the hull or deck,...

  4. The Art of Collection Development: Reference Style.

    ERIC Educational Resources Information Center

    Schmitt, John P.

    1998-01-01

    Discusses selecting for a reference collection, creative budgeting, cutting a deal, collection awareness (strengths/needs), Web site reviews, R-Net (reviews from diverse areas and institutions), and print vs. electronic reference products. Reference librarian adhere to high standards for reference book and Web sites, teach assessment techniques,…

  5. Bibliographic databases: help in preparing reference lists.

    PubMed

    Biancuzzo, M

    1995-01-01

    Typing bibliography references is time consuming. It is also frustrating to have to retype references when you submit a manuscript to journals using different reference styles. Now you don't need to retype them. Computer programs have been developed which help you reorganize your references to many different styles. This experienced nurse author compares several of these programs for you. PMID:7613563

  6. Instant Messaging Reference: How Does It Compare?

    ERIC Educational Resources Information Center

    Desai, Christina M.

    2003-01-01

    Compares a digital reference service that uses instant messaging with traditional, face-to-face reference based on experiences at the Southern Illinois University library. Addresses differences in reference questions asked, changes in the reference transaction, student expectations, bibliographic instruction, and librarian attitudes and procedures…

  7. American Folklore: A Guide to Reference Sources.

    ERIC Educational Resources Information Center

    Kibbee, Jo

    1989-01-01

    This annotated bibliography represents a core collection of reference sources on American folklore. In addition to general references, genre specific reference sources are listed in the following areas: folk narrative; folk music; customary folklore; material culture; ethnic and regional bibliographies; and applied folklore. (39 references) (CLB)

  8. Improving the Quality of Telephone Reference Service.

    ERIC Educational Resources Information Center

    Quinn, Brian

    1995-01-01

    Discusses telephone reference services in libraries. Topics include characteristics of quality phone reference; policies and guidelines for quality service; a survey of pertinent literature evaluating telephone reference; training; and technology for telephone reference, including cellular and cordless phones, electronic resources, and automated…

  9. 40 CFR 1042.910 - Reference materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... reference as prescribed in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Reference materials. 1042.910 Section... Other Reference Information § 1042.910 Reference materials. Documents listed in this section have...

  10. 40 CFR 1042.910 - Reference materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reference as prescribed in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Reference materials. 1042.910 Section... Other Reference Information § 1042.910 Reference materials. Documents listed in this section have...

  11. Resonance behaviour of whole-body averaged specific energy absorption rate (SAR) in the female voxel model, NAOMI

    NASA Astrophysics Data System (ADS)

    Dimbylow, Peter

    2005-09-01

    Finite-difference time-domain (FDTD) calculations have been performed of the whole-body averaged specific energy absorption rate (SAR) in a female voxel model, NAOMI, under isolated and grounded conditions from 10 MHz to 3 GHz. The 2 mm resolution voxel model, NAOMI, was scaled to a height of 1.63 m and a mass of 60 kg, the dimensions of the ICRP reference adult female. Comparison was made with SAR values from a reference male voxel model, NORMAN. A broad SAR resonance in the NAOMI values was found around 900 MHz and a resulting enhancement, up to 25%, over the values for the male voxel model, NORMAN. This latter result confirmed previously reported higher values in a female model. The effect of differences in anatomy was investigated by comparing values for 10-, 5- and 1-year-old phantoms rescaled to the ICRP reference values of height and mass which are the same for both sexes. The broad resonance in the NAOMI child values around 1 GHz is still a strong feature. A comparison has been made with ICNIRP guidelines. The ICNIRP occupational reference level provides a conservative estimate of the whole-body averaged SAR restriction. The linear scaling of the adult phantom using different factors in longitudinal and transverse directions, in order to match the ICRP stature and weight, does not exactly reproduce the anatomy of children. However, for public exposure the calculations with scaled child models indicate that the ICNIRP reference level may not provide a conservative estimate of the whole-body averaged SAR restriction, above 1.2 GHz for scaled 5- and 1-year-old female models, although any underestimate is by less than 20%.

  12. Dietary Reference Intakes (DRIs) in Japan.

    PubMed

    Sasaki, Satoshi

    2008-01-01

    Following the comprehensive systematic review of domestic and overseas scientific evidence, the "Dietary Reference Intakes for Japanese, 2005 (DRI-J)" was published in April, 2005. The DRIs-J were prepared for health individuals and groups and designed to present a reference for intake values of energy and 34 nutrients to maintain and promote health and to prevent lifestyle-related diseases and illness due to excessive consumption of either energy or nutrients. The DRI-J also includes a special chapter for basic knowledge of DRIs. The energy recommendation is provided as an estimated energy requirement (EER), while five indices were used for nutrients: Estimated average requirement (EAR), recommended dietary allowance (RDA), adequate intake (AI), tolerable upper intake level (UL), and tentative dietary goal for preventing lifestyle-related [chronic non-communicable] diseases (DG). Whilst the first four indices are same as the ones used in other countries, DG is unique index in Japan, which was set as a reference value for preventing non-communicable diseases such as cardiovascular (including hypertension), major types of cancer and osteoporosis. This report (DRI-J) is the first dietary guidance in Japan, which applied evidence-based approach utilizing a systematic review process. Only a few articles from within Japan and other Asian countries could be used for its establishment. The project to establish the DRI-J revealed a severe lack of researchers and publications focused upon establishing DRIs for Japanese. Further review is therefore required in preparation for the next revision scheduled in 2010.

  13. Genetics Home Reference: Mabry syndrome

    MedlinePlus

    ... features, increased levels of an enzyme called alkaline phosphatase in the blood (hyperphosphatasia), and other signs and ... syndrome . There are many different types of alkaline phosphatase found in tissues; the type that is increased ...

  14. Genetics Home Reference: beta thalassemia

    MedlinePlus

    ... a blood disorder that reduces the production of hemoglobin . Hemoglobin is the iron-containing protein in red blood ... In people with beta thalassemia , low levels of hemoglobin lead to a lack of oxygen in many ...

  15. Genetics Home Reference: Wolfram syndrome

    MedlinePlus

    ... called the endoplasmic reticulum that is involved in protein production, processing, and transport. Wolframin's function is important in ... sugar levels. WFS1 gene mutations lead to the production of a wolframin protein that has reduced or absent function. As a ...

  16. Genetics Home Reference: Sandhoff disease

    MedlinePlus

    ... rare inherited disorder that progressively destroys nerve cells (neurons) in the brain and spinal cord. The most ... compounds can accumulate to toxic levels, particularly in neurons of the brain and spinal cord. A buildup ...

  17. Background stratospheric aerosol reference model

    NASA Technical Reports Server (NTRS)

    Mccormick, M. P.; Wang, P.

    1989-01-01

    In this analysis, a reference background stratospheric aerosol optical model is developed based on the nearly global SAGE 1 satellite observations in the non-volcanic period from March 1979 to February 1980. Zonally averaged profiles of the 1.0 micron aerosol extinction for the tropics and the mid- and high-altitudes for both hemispheres are obtained and presented in graphical and tabulated form for the different seasons. In addition, analytic expressions for these seasonal global zonal means, as well as the yearly global mean, are determined according to a third order polynomial fit to the vertical profile data set. This proposed background stratospheric aerosol model can be useful in modeling studies of stratospheric aerosols and for simulations of atmospheric radiative transfer and radiance calculations in atmospheric remote sensing.

  18. SNAP operating system reference manual

    SciTech Connect

    Sabuda, J.D.; Polito, J.; Walker, J.L.; Grant, F.H. III

    1982-03-01

    The SNAP Operating System (SOS) is a FORTRAN 77 program which provides assistance to the safeguards analyst who uses the Safeguards Automated Facility Evaluation (SAFE) and the Safeguards Network Analysis Procedure (SNAP) techniques. Features offered by SOS are a data base system for storing a library of SNAP applications, computer graphics representation of SNAP models, a computer graphics editor to develop and modify SNAP models, a SAFE-to-SNAP interface, automatic generation of SNAP input data, and a computer graphic post-processor for SNAP. The SOS Reference Manual provides detailed application information concerning SOS as well as a detailed discussion of all SOS components and their associated command input formats. SOS was developed for the US Nuclear Regulatory Commission's Office of Nuclear Regulatory Research and the US Naval Surface Weapons Center by Pritsker and Associates, Inc., under contract to Sandia National Laboratories.

  19. Hazard Communication Project: reference manual

    SciTech Connect

    Not Available

    1989-03-01

    This reference manual covers the following course objectives: to inform employees of their employer's requirements under the OSHA Hazard Communication Standard (29 CFR 1910.1200); to instruct employees on the procedures for obtaining and using information on hazardous materials, including understanding labeling systems and the material safety data sheet (MSDS) information; to provide information on 11 classes of chemicals, including their common uses, potential physical and health hazards, detection methods, and safety measures to follow. There are 14 lessons, ranging in length from 30 minutes to 1 (one) hour. The lessons are contained on 6 disks that are programmed to run on an IBM-compatible PC with an EGA graphics card and monitor. The program will not run on monochrome or CGA systems.

  20. NUCLEAR SCIENCE REFERENCES CODING MANUAL

    SciTech Connect

    WINCHELL,D.F.

    2007-04-01

    This manual is intended as a guide for Nuclear Science References (NSR) compilers. The basic conventions followed at the National Nuclear Data Center (NNDC), which are compatible with the maintenance and updating of and retrieval from the Nuclear Science References (NSR) file, are outlined. The NSR database originated at the Nuclear Data Project (NDP) at Oak Ridge National Laboratory as part of a project for systematic evaluation of nuclear structure data.1 Each entry in this computer file corresponds to a bibliographic reference that is uniquely identified by a Keynumber and is describable by a Topic and Keywords. It has been used since 1969 to produce bibliographic citations for evaluations published in Nuclear Data Sheets. Periodic additions to the file were published as the ''Recent References'' issues of Nuclear Data Sheets prior to 2005. In October 1980, the maintenance and updating of the NSR file became the responsibility of the NNDC at Brookhaven National Laboratory. The basic structure and contents of the NSR file remained unchanged during the transfer. In Chapter 2, the elements of the NSR file such as the valid record identifiers, record contents, and text fields are enumerated. Relevant comments regarding a new entry into the NSR file and assignment of a keynumber are also given in Chapter 2. In Chapter 3, the format for keyword abstracts is given followed by specific examples; for each TOPIC, the criteria for inclusion of an article as an entry into the NSR file as well as coding procedures are described. Authors preparing Keyword abstracts either to be published in a Journal (e.g., Nucl. Phys. A) or to be sent directly to NNDC (e.g., Phys. Rev. C) should follow the illustrations in Chapter 3. The scope of 1See W.B.Ewbank, ORNL-5397 (1978). the literature covered at the NNDC, the categorization into Primary and Secondary sources, etc., is discussed in Chapter 4. Useful information regarding permitted character sets, recommended abbreviations, etc., is

  1. Primary Atomic Clock Reference System

    NASA Technical Reports Server (NTRS)

    2001-01-01

    An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0103191

  2. Primary Atomic Clock Reference System

    NASA Technical Reports Server (NTRS)

    2001-01-01

    An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0100120.

  3. Reference condition approach to restoration planning

    USGS Publications Warehouse

    Nestler, J.M.; Theiling, C.H.; Lubinski, S.J.; Smith, D.L.

    2010-01-01

    Ecosystem restoration planning requires quantitative rigor to evaluate alternatives, define end states, report progress and perform environmental benefits analysis (EBA). Unfortunately, existing planning frameworks are, at best, semi-quantitative. In this paper, we: (1) describe a quantitative restoration planning approach based on a comprehensive, but simple mathematical framework that can be used to effectively apply knowledge and evaluate alternatives, (2) use the approach to derive a simple but precisely defined lexicon based on the reference condition concept and allied terms and (3) illustrate the approach with an example from the Upper Mississippi River System (UMRS) using hydrologic indicators. The approach supports the development of a scaleable restoration strategy that, in theory, can be expanded to ecosystem characteristics such as hydraulics, geomorphology, habitat and biodiversity. We identify three reference condition types, best achievable condition (A BAC), measured magnitude (MMi which can be determined at one or many times and places) and desired future condition (ADFC) that, when used with the mathematical framework, provide a complete system of accounts useful for goal-oriented system-level management and restoration. Published in 2010 by John Wiley & Sons, Ltd.

  4. Mass storage system reference model, Version 4

    NASA Technical Reports Server (NTRS)

    Coleman, Sam (Editor); Miller, Steve (Editor)

    1993-01-01

    The high-level abstractions that underlie modern storage systems are identified. The information to generate the model was collected from major practitioners who have built and operated large storage facilities, and represents a distillation of the wisdom they have acquired over the years. The model provides a common terminology and set of concepts to allow existing systems to be examined and new systems to be discussed and built. It is intended that the model and the interfaces identified from it will allow and encourage vendors to develop mutually-compatible storage components that can be combined to form integrated storage systems and services. The reference model presents an abstract view of the concepts and organization of storage systems. From this abstraction will come the identification of the interfaces and modules that will be used in IEEE storage system standards. The model is not yet suitable as a standard; it does not contain implementation decisions, such as how abstract objects should be broken up into software modules or how software modules should be mapped to hosts; it does not give policy specifications, such as when files should be migrated; does not describe how the abstract objects should be used or connected; and does not refer to specific hardware components. In particular, it does not fully specify the interfaces.

  5. GLOBAL REFERENCE ATMOSPHERIC MODELS FOR AEROASSIST APPLICATIONS

    NASA Technical Reports Server (NTRS)

    Duvall, Aleta; Justus, C. G.; Keller, Vernon W.

    2005-01-01

    Aeroassist is a broad category of advanced transportation technology encompassing aerocapture, aerobraking, aeroentry, precision landing, hazard detection and avoidance, and aerogravity assist. The eight destinations in the Solar System with sufficient atmosphere to enable aeroassist technology are Venus, Earth, Mars, Jupiter, Saturn, Uranus, Neptune, and Saturn's moon Titan. Engineering-level atmospheric models for five of these targets - Earth, Mars, Titan, Neptune, and Venus - have been developed at NASA's Marshall Space Flight Center. These models are useful as tools in mission planning and systems analysis studies associated with aeroassist applications. The series of models is collectively named the Global Reference Atmospheric Model or GRAM series. An important capability of all the models in the GRAM series is their ability to simulate quasi-random perturbations for Monte Carlo analysis in developing guidance, navigation and control algorithms, for aerothermal design, and for other applications sensitive to atmospheric variability. Recent example applications are discussed.

  6. Comparing Virtual Reference Exit Survey Results and Transcript Analysis: A Model for Service Evaluation

    ERIC Educational Resources Information Center

    Smyth, Joanne B.; MacKenzie, James C.

    2006-01-01

    This study uses virtual reference transcripts for which patrons completed exit surveys to seek any correlations between user and librarian satisfaction within virtual reference transactions. By analyzing transcripts with a focus on three elements-technology performance, preferred reference practices, and the demonstrated communication levels of…

  7. Dietary intake and anthropometric reference values in population studies.

    PubMed

    Arija, Victoria; Pérez Rodrigo, Carmen; Martínez de Vitoria, Emilio; Ortega, Rosa M; Serra-Majem, Luis; Ribas, Lourdes; Aranceta, Javier

    2015-02-26

    In nutritional epidemiology it is essential to have reference values for nutrition and anthropometry in order to compare individual and population data. With respect to reference nutritional intake, the new concept of Dietary Reference Intakes is generated based more on the prevention of chronic diseases than on covering nutritional deficiencies, as would occur in the early Recommendations. As such, the more relevant international organizations incorporated new concepts in their tables, such as the Adequate Intake levels or the Tolerable Upper Intake levels. Currently, the EURRECA recommendations (EURopean micronutrient RECommendations Aligned) are generating reference values for Europe in a transparent, systematic and scientific manner. Using the DRI, health-care authorities formulated nutritional objectives for countries or territories and Dietary Guides to disseminate the dietary advice to the population. Anthropometric assessment continues to be one of the most-used methods for evaluating and monitoring health status, nutritional state and growth in children, not only individuals but also communities. Different organizations have established anthropometric reference patterns of body mass index (BMI) with cut-off points to define overweight and obesity. In children, growth curves have been revised and adapted to the characteristics of healthy children in order to obtain anthropometric reference standards that better reflect optimum growth in children. The Growth Standards for children below 5 years of age of the WHO are a response to these principles, and are widely accepted and used worldwide.

  8. Constructing reference metrics on multicube representations of arbitrary manifolds

    NASA Astrophysics Data System (ADS)

    Lindblom, Lee; Taylor, Nicholas W.; Rinne, Oliver

    2016-05-01

    Reference metrics are used to define the differential structure on multicube representations of manifolds, i.e., they provide a simple and practical way to define what it means globally for tensor fields and their derivatives to be continuous. This paper introduces a general procedure for constructing reference metrics automatically on multicube representations of manifolds with arbitrary topologies. The method is tested here by constructing reference metrics for compact, orientable two-dimensional manifolds with genera between zero and five. These metrics are shown to satisfy the Gauss-Bonnet identity numerically to the level of truncation error (which converges toward zero as the numerical resolution is increased). These reference metrics can be made smoother and more uniform by evolving them with Ricci flow. This smoothing procedure is tested on the two-dimensional reference metrics constructed here. These smoothing evolutions (using volume-normalized Ricci flow with DeTurck gauge fixing) are all shown to produce reference metrics with constant scalar curvatures (at the level of numerical truncation error).

  9. PEP liquid level system

    SciTech Connect

    Lauritzen, T.; Sah, R.C.

    1981-03-01

    A liquid level system has been installed in the accelerator housing of the PEP storage ring. This instrument spans the entire 2.2 km circumference of the PEP project, and over one hundred readouts provide reference elevations which are used for the accurate alignment of accelerator components. The liquid level has proven to be extremely precise (+-0.10 mm) and quick to use, and it has contributed to the accurate alignment of PEP before beam turn-on. Since the liquid level readouts are rigidly attached to the accelerator housing, the liquid level has been a convenient means to monitor the settling of the accelerator housing.

  10. Genetics Home Reference: Darier disease

    MedlinePlus

    ... The ATP2A2 gene provides instructions for producing an enzyme abbreviated as SERCA2. This enzyme acts as a pump that helps control the ... gene result in insufficient amounts of functional SERCA2 enzyme. A lack of SERCA2 enzyme reduces calcium levels ...

  11. Genetics Home Reference: essential pentosuria

    MedlinePlus

    ... characterized by high levels of a sugar called L-xylulose in urine. The condition is so named because L-xylulose is a type of sugar called a ... instructions for making a protein called dicarbonyl and L-xylulose reductase (DCXR), which plays multiple roles in ...

  12. Research Notes and Information References

    1994-12-01

    The RNS (Research Notes System) is a set of programs and databases designed to aid the research worker in gathering, maintaining, and using notes taken from the literature. The sources for the notes can be books, journal articles, reports, private conversations, conference papers, audiovisuals, etc. The system ties the databases together in a relational structure, thus eliminating data redundancy while providing full access to all the information. The programs provide the means for access andmore » data entry in a way that reduces the key-entry burden for the user. Each note has several data fields. Included are the text of the note, the subject classification (for retrieval), and the reference identification data. These data are divided into four databases: Document data - title, author, publisher, etc., fields to identify the article within the document; Note data - text and page of the note; Sublect data - subject categories to ensure uniform spelling for searches. Additionally, there are subsidiary files used by the system, including database index and temporary work files. The system provides multiple access routes to the notes, both structurally (access method) and topically (through cross-indexing). Output may be directed to a printer or saved as a file for input to word processing software.« less

  13. International Reference Ionosphere - Status 2004

    NASA Astrophysics Data System (ADS)

    Bilitza, D.; Reinisch, B.; Triskova, L.; Friedrich, M.

    The International Reference Ionosphere (IRI) is the standard for ionospheric densities and temperatures as recommended by the International Union of Radio Science (URSI) and the Committee on Space Research (COSPAR). A COSPAR/URSI Working Group is in charge of developing and improving the model. It currently consists of 43 members who work on different aspects of the modeling effort. By charter IRI is an empirical model that attempts to represent the combined ionospheric database of ground and space observations as accurately as possible. IRI provides monthly averages of the electron density, total electron content, electron temperature, ion temperature, ion composition (O+, H+, He+, N+, O2+, NO+, Cluster+) and vertical ion drift (at the equator). This paper reports about the most recent activities of the IRI Working Group and about the most recent updates of the IRI model. We review the presentations, discussions, and results of the 2003 IRI Workshop held in Grahamstown, South Africa. Special emphasis will be given to the improvements that are of importance for the IRI model now being proposed as ISO standard

  14. Argon Purification Reference and Recommendation

    SciTech Connect

    Wu, J.; /Fermilab

    1991-05-23

    This engineering note is a reference for future consideration on the purification of argon. The original concern was for the possibility of argon contamination from components in the cryostats over long-term storage. An argon purification system could also be useful for purifying the contents of the argon dewar. The general conclusion is that most of the systems researched are too expensive at this time, but the recommended choice would be Centorr Furnaces. There were three basic types of purification systems which were to be considered. The first was the molecular sieve. This method would have been the preferred one, because it was claimed that it could purify liquid argon, removing liquid oxygen from the argon. However, none of the commercial companies researched provided this type of purification for use with liquid argon. Most companies said that this type of purification was impossible, and tests at IB-4 confirmed this. The second system contained a copper oxide to remove gaseous oxygen from argon gas. The disadvantage of this system wass that the argon had to be heated to a gas, and then cooled back down to liquid. The third system was similar to the second, except that it used tungsten or another material like titanium. This system also needed to heat the argon to gas, however the advantage of this system was that it supposedly removed all contaminants, that is, everything except for inert gases. Of the three systems, the third is the type manufactured by Centorr Furnaces, which uses a titanium charge.

  15. Reference materials for cellular therapeutics.

    PubMed

    Bravery, Christopher A; French, Anna

    2014-09-01

    The development of cellular therapeutics (CTP) takes place over many years, and, where successful, the developer will anticipate the product to be in clinical use for decades. Successful demonstration of manufacturing and quality consistency is dependent on the use of complex analytical methods; thus, the risk of process and method drift over time is high. The use of reference materials (RM) is an established scientific principle and as such also a regulatory requirement. The various uses of RM in the context of CTP manufacturing and quality are discussed, along with why they are needed for living cell products and the analytical methods applied to them. Relatively few consensus RM exist that are suitable for even common methods used by CTP developers, such as flow cytometry. Others have also identified this need and made proposals; however, great care will be needed to ensure any consensus RM that result are fit for purpose. Such consensus RM probably will need to be applied to specific standardized methods, and the idea that a single RM can have wide applicability is challenged. Written standards, including standardized methods, together with appropriate measurement RM are probably the most appropriate way to define specific starting cell types. The characteristics of a specific CTP will to some degree deviate from those of the starting cells; consequently, a product RM remains the best solution where feasible. Each CTP developer must consider how and what types of RM should be used to ensure the reliability of their own analytical measurements.

  16. Research Notes and Information References

    SciTech Connect

    Hartley, III, Dean S.

    1994-12-01

    The RNS (Research Notes System) is a set of programs and databases designed to aid the research worker in gathering, maintaining, and using notes taken from the literature. The sources for the notes can be books, journal articles, reports, private conversations, conference papers, audiovisuals, etc. The system ties the databases together in a relational structure, thus eliminating data redundancy while providing full access to all the information. The programs provide the means for access and data entry in a way that reduces the key-entry burden for the user. Each note has several data fields. Included are the text of the note, the subject classification (for retrieval), and the reference identification data. These data are divided into four databases: Document data - title, author, publisher, etc., fields to identify the article within the document; Note data - text and page of the note; Sublect data - subject categories to ensure uniform spelling for searches. Additionally, there are subsidiary files used by the system, including database index and temporary work files. The system provides multiple access routes to the notes, both structurally (access method) and topically (through cross-indexing). Output may be directed to a printer or saved as a file for input to word processing software.

  17. Fortran 5 cross-reference

    SciTech Connect

    Brenneman, D.J.; Singer, G.L.

    1984-01-01

    This manual describes FSTCOM and ROUTS, two cross-referencing programs. The programs have been prepared by EG and G Idaho, Inc. at the Idaho Nuclear Engineering Laboratory and are written in CDC FORTRAN 5, following the standard FORTRAN 77 conventions. FSTCOM and ROUTS facilitate the creation of documentation for programs. Additionally, the programs are of great help in the debugging process due to the nature of their output. To aid the user, the programs are carefully documented. In fact, most users can run FSTCOM or ROUTS by simply referring to the prologue at the beginning of each program. FSTCOM creates reports concerning the common blocks in a FORTRAN 5 program by using a FTN5 compiled listing as input. Common block information contained in the listing is collected in an interface file for future output. However, it is important to note that only the common variables actually used in the program will be stored in the interface file. ROUTS generates a report concerning the program units and the procedures they call. Like FSTCOM, ROUTS uses a FTN5 compiled listing as input. The program unit information is collected into an interface file that is sorted by the CYBER SORT/MERGE utility to produce a report. 2 figures, 4 tables.

  18. Establishment of reference standards in biosimilar studies.

    PubMed

    Zhang, Aijing; Tzeng, Jung-Ying; Chow, Shein-Chung

    2013-07-31

    When an innovative biological product goes off-patent, biopharmaceutical or biotechnological companies may file an application for regulatory approval of biosimilar products. In practice, however, important information on the innovative (reference) product may not be available for assessment. Thus, it is important to first establish a reference standard while assessing biosimilarity between a biosimilar product and the reference product. In this paper, reference standard is established through the biosimilarity index approach based on a reference-replicated study (or R-R study), in which the reference product is compared with itself under various scenarios. The reference standard can then be used for assessing the degree of similarity between the test and reference drugs in biosimilar studies.

  19. Chinese-Mandarin Basic Course: References.

    ERIC Educational Resources Information Center

    Defense Language Inst., Monterey, CA.

    This is a collection of reference materials to be used with the Chinese-Mandarin Basic Course textbooks. This collection consists of information on romanization systems, indexes for reading and writing characters, and other tables for quick reference. (NCR)

  20. Independent Study Unit on Accelerated Reference Frames

    ERIC Educational Resources Information Center

    Poultney, S. K.

    1973-01-01

    Presents a list of topics, research areas, references, and laboratory equipment which is prepared to facilitate general-science students' understanding of physics aspects in accelerated reference frames after their study of circular motion and Galilean relativity in mechanics. (CC)

  1. Reference surfaces for bridge scour depths

    USGS Publications Warehouse

    Landers, Mark N.; Mueller, David S.

    1993-01-01

    Depth of scour is measured as the vertical distance between scoured channel geometry and a measurement reference surface. A scour depth measurement can have a wide range depending on the method used to establish the reference surface. A consistent method to establish reference surfaces for bridge scour measurements is needed to facilitate transferability of scour data an scour analyses. This paper describes and evaluates techniques for establishing reference surfaces from which local and contraction scour are measured.

  2. Assessment of physiotherapists' occupational exposure to radiofrequency electromagnetic fields from shortwave and microwave diathermy devices: a literature review.

    PubMed

    Shah, Syed Ghulam Sarwar; Farrow, Alexandra

    2013-01-01

    We reviewed studies reporting the strength of radiofrequency (RF) electromagnetic fields (EMF) in physiotherapists' occupational environment. Studies from academic journals published from January 1990 to June 2010 were identified in nine online bibliographic databases. EMF strength was compared with occupational exposure limits (OELs) recommended by the International Commission on Non-Ionizing Radiation Protection (ICNIRP). In the reviewed studies, EMFs were measured at different distances (range 0.2 m to 6 m) from the console of diathermy devices, electrodes, and cables. For continuous shortwave diathermy (CSWD) (27.12 megahertz, MHz), measurements of EMFs at < 1 m, 1 m, 1.1-1.5 m, and 2 m reported the maximum E field strength as 8197%, 1639%, 295%, and 69%, respectively, and the maximum H field strength as 6250%, 681%, 213%, and 56%, respectively, of the ICNIRP limits for E and H fields for occupational exposure. For pulsed shortwave diathermy (PSWD) (27.12 MHz), EMF measurements at < 1 m, 1 m, and, 1.1-1.5 m showed the maximum E field intensity as 1639%, 175%, and 32%, and the maximum H field strength as 1175%, 968%, and 28%, respectively, of the ICNIRP limits for E and H fields for occupational exposure. For microwave diathermy (MWD) (2.45 gigahertz, GHz), the maximum power density measured at < 1 m, 1 m, 1.1-1.5 m, and 2 m was 200%, <30%, 0.76%, and 0.82%, respectively, of the ICNIRP limit for occupational exposure. RF EMF emissions measured from continuous and pulsed electrotherapeutic diathermy devices may well be higher than OELs at specific distances, i.e., at 1 m, which is currently designated to be a safe distance for physiotherapists. The minimum safe distance for physiotherapists should be revised to at least 2 m for CSWD and 1.5 m for PSWD. The reviewed studies did not provide evidence of exceeding the ICNIRP's reference levels for occupational exposure at 1 m from MWD devices. PMID:23570423

  3. Reference Use of Online Databases: An Analysis.

    ERIC Educational Resources Information Center

    Friend, Linda; Bonta, Bruce

    Since July 1978 the general reference section of the Pennsylvania State University library has compiled statistical information related to the use of online searching for reference purposes. An evaluation form completed by the librarian for each online reference search recorded such information as search date; status of requestor; printed sources…

  4. The Internet: A Ready Reference Library?

    ERIC Educational Resources Information Center

    Gabriel, Michael R.

    1998-01-01

    An academic librarian answered 24 questions using reference books, then tried to answer the same questions using an Internet search engine (Metacrawler). Evaluates the results of the Internet searches and discusses implications for library reference services and reference book publishers; Internet user expectations and satisfaction; and librarians…

  5. 49 CFR 171.7 - Reference material.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... incorporation by reference by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR..., into § 173.417. (2) Table 1 to 49 CFR 171.7—Materials Not Incorporated by Reference Source and name of material 49 CFR reference American Biological Safety Association 1202 Allanson Road, Mundelein, IL...

  6. 49 CFR 171.7 - Reference material.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... incorporation by reference by the Director of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR..., amendment 1 (2011). Table 1 to 49 CFR 171.7—Materials Not Incorporated by Reference Source and name of material 49 CFR reference American Biological Safety Association 1202 Allanson Road, Mundelein, IL...

  7. Frames of Reference in the Classroom

    ERIC Educational Resources Information Center

    Grossman, Joshua

    2012-01-01

    The classic film "Frames of Reference" effectively illustrates concepts involved with inertial and non-inertial reference frames. In it, Donald G. Ivey and Patterson Hume use the cameras perspective to allow the viewer to see motion in reference frames translating with a constant velocity, translating while accelerating, and rotating--all with…

  8. Environmental Sciences Reference Sources. An Annotated Bibliography.

    ERIC Educational Resources Information Center

    McMartin, Mary I., Comp.

    This list of Environmental Sciences References Sources is intended to give undergraduate and graduate students a starting point when searching for information in the library. Entries are grouped according to type of reference material and then are listed in alphabetical order. The types of reference material included are guides to dictionaries,…

  9. Information/Reference Desk Procedures Manual.

    ERIC Educational Resources Information Center

    Helms, Cynthia Mae; Nelson, Judith

    This manual ensures that the personnel who work at the Information/Reference Desk of the James White Library, Andrews University carry out similar procedures regardless of their shift. It serves as an orientation tool and a reference guide, and gives procedures for dealing with patrons, answering reference questions, making the right referrals,…

  10. Communication Theory's Role in the Reference Interview.

    ERIC Educational Resources Information Center

    Glogoff, Stuart

    1983-01-01

    Notes the applicability of communication science theory to the reference process, particularly in areas involving human behavior, and discusses the roles of both verbal and nonverbal communication (body language, paralanguage, proxemics, and environmental factors) in the reference interview. Forty-one references are provided. (EJS)

  11. Ties Between Celestial And Planetary Reference Frames

    NASA Technical Reports Server (NTRS)

    Finger, Mark H.; Folkner, William M.

    1992-01-01

    Report presents new determination of relative orientation (or frame tie) between reference frame of extra-galactic radio sources and reference frame of planetary ephemeris. Method employed for improved frame-tie estimate relies on ability to measure orientation of Earth with respect to inertial reference frame. Improves orbit determination for interplanetary spacecraft.

  12. Rethinking Job References: A Networking Challenge

    ERIC Educational Resources Information Center

    Muir, Clive

    2009-01-01

    Can job references play an active role in shaping one's career plans? Would individuals consider their references as part of their personal and professional network? Although most professionals may respond with a resounding "Yes, of course!" to these questions, the author realized that many of his students were skeptical about job references. To…

  13. 40 CFR 1043.100 - Reference materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air and Radiation... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Reference materials. 1043.100 Section... § 1043.100 Reference materials. Documents listed in this section have been incorporated by reference...

  14. 40 CFR 1043.100 - Reference materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air and Radiation... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Reference materials. 1043.100 Section... § 1043.100 Reference materials. Documents listed in this section have been incorporated by reference...

  15. Current Issues in Reference and Adult Services.

    ERIC Educational Resources Information Center

    Hansen, Andrew M., Ed.; And Others

    1985-01-01

    This five-article section on current issues in reference and adult services highlights origins of American Library Association's Reference and Adult Services Division, history and development of RQ's column "The Exchange," 25 years of adult services articles, documents reference service and changing attitudes of librarians, and library literacy.…

  16. APEX (Air Pollution Exercise) Volume 20: Reference Materials.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Research Triangle Park, NC. Office of Manpower Development.

    The Reference Materials Manual is part of a set of 21 manuals (AA 001 009-001 029) used in APEX (Air Pollution Exercise), a computerized college and professional level "real world" game simulation of a community with urban and rural problems, industrial activities, and air pollution difficulties. For the purposes of the gaming exercise, APEX…

  17. Phase inverter provides variable reference push-pull output

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Dual-transistor difference amplifier provides a push-pull output referenced to a dc potential which can be varied without affecting the signal levels. The amplifier is coupled with a feedback circuit which can vary the operating points of the transistors by equal amounts to provide the variable reference potentials.

  18. A Reference Grammar of Dutch, with Exercises and Key.

    ERIC Educational Resources Information Center

    Fehringer, Carol

    This textbook provides an accessible reference grammar of the Dutch language for English-speaking students of Dutch to help consolidate their knowledge through practical exercises on a whole range of grammatical topics. It is intended both for beginners and intermediate level students. Advanced learners of Dutch wishing to review particular…

  19. Generic Argillite/Shale Disposal Reference Case

    SciTech Connect

    Zheng, Liange; Colon, Carlos Jové; Bianchi, Marco; Birkholzer, Jens

    2014-08-08

    Radioactive waste disposal in a deep subsurface repository hosted in clay/shale/argillite is a subject of widespread interest given the desirable isolation properties, geochemically reduced conditions, and widespread geologic occurrence of this rock type (Hansen 2010; Bianchi et al. 2013). Bianchi et al. (2013) provides a description of diffusion in a clay-hosted repository based on single-phase flow and full saturation using parametric data from documented studies in Europe (e.g., ANDRA 2005). The predominance of diffusive transport and sorption phenomena in this clay media are key attributes to impede radionuclide mobility making clay rock formations target sites for disposal of high-level radioactive waste. The reports by Hansen et al. (2010) and those from numerous studies in clay-hosted underground research laboratories (URLs) in Belgium, France and Switzerland outline the extensive scientific knowledge obtained to assess long-term clay/shale/argillite repository isolation performance of nuclear waste. In the past several years under the UFDC, various kinds of models have been developed for argillite repository to demonstrate the model capability, understand the spatial and temporal alteration of the repository, and evaluate different scenarios. These models include the coupled Thermal-Hydrological-Mechanical (THM) and Thermal-Hydrological-Mechanical-Chemical (THMC) models (e.g. Liu et al. 2013; Rutqvist et al. 2014a, Zheng et al. 2014a) that focus on THMC processes in the Engineered Barrier System (EBS) bentonite and argillite host hock, the large scale hydrogeologic model (Bianchi et al. 2014) that investigates the hydraulic connection between an emplacement drift and surrounding hydrogeological units, and Disposal Systems Evaluation Framework (DSEF) models (Greenberg et al. 2013) that evaluate thermal evolution in the host rock approximated as a thermal conduction process to facilitate the analysis of design options. However, the assumptions and the

  20. Prehension synergies and control with referent hand configurations

    PubMed Central

    Friedman, Jason; Kim, Sun Wook; Feldman, Anatol G.; Zatsiorsky, Vladimir M.

    2010-01-01

    We used the framework of the equilibrium-point hypothesis (in its updated form based on the notion of referent configuration) to investigate the multi-digit synergies at two levels of a hypothetical hierarchy involved in prehensile actions. Synergies were analyzed at the thumb–virtual finger (VF) level (VF is an imaginary digit with the mechanical action equivalent to that of the four actual fingers) and at the individual finger level. The subjects performed very quick vertical movements of a handle into a target. A load could be attached off-center to provide a pronation or supination torque. In a few trials, the handle was unexpectedly fixed to the table and the digits slipped off the sensors. In such trials, the hand stopped at a higher vertical position and rotated into pronation or supination depending on the expected torque. The aperture showed non-monotonic changes with a large, fast decrease and further increase, ending up with a smaller distance between the thumb and the fingers as compared to unperturbed trials. Multi-digit synergies were quantified using indices of co-variation between digit forces and moments of force across unperturbed trials. Prior to the lifting action, high synergy indices were observed at the individual finger level while modest indices were observed at the thumb–VF level. During the lifting action, the synergies at the individual finger level disappeared while the synergy indices became higher at the thumb–VF level. The results support the basic premise that, within a given task, setting a referent configuration may be described with a few referent values of variables that influence the equilibrium state, to which the system is attracted. Moreover, the referent configuration hypothesis can help interpret the data related to the trade-off between synergies at different hierarchical levels. PMID:20033397

  1. Terrestrial Reference Frame from GPS and SLR

    NASA Astrophysics Data System (ADS)

    Weiss, Jan; Bertiger, Willy; Desai, Shailen; Haines, Bruce; Sibois, Aurore

    2015-04-01

    We present strategies for realizing the terrestrial reference frame (TRF) using tracking data from terrestrial GPS receivers alone and in tandem with the GRACE and LAGEOS satellites. We generate solutions without apriori ties to the International Terrestrial Reference Frame (ITRF). Our approach relies on processing multi-day orbit arcs to take advantage of the satellite dynamics, GPS receiver and transmitter calibrations derived from low-Earth orbiter (LEO) data, and estimation strategies tuned for realizing a stable and accurate TRF. We furthermore take advantage of the geometric diversity provided by GPS tracking from GRACE, and explore the impacts of including ground-based satellite laser range (SLR) measurements to LAGEOS-1 and -2 with local ties relating the two geodetic techniques. We process data from 2003-2014 and compute Helmert transformations relative to ITRF/IGb08. With GPS alone we achieve a 3D origin offset and rate of <7 mm and <1 mm/yr, and reduce the offset to <4 mm when GRACE is included in the global solutions. Scale bias and rate are 3.1 ppb and 0.01 ppb/yr in either solution. Including SLR tracking from 11 ground stations to the LAGEOS satellites from 2012-2014 yields a reduction in scale bias of 0.5-1.0 ppb depending on the weight assigned to the SLR measurements. However, scatter is increased due to the relatively sparse SLR tracking network. We conclude with approaches for improving the TRF realized from GPS and SLR combined at the measurement level.

  2. Reference drug programs: effectiveness and policy implications.

    PubMed

    Schneeweiss, Sebastian

    2007-04-01

    In the current economic environment, health care systems are constantly struggling to contain rapidly rising costs. Drug costs are targeted by a wide variety of measures. Many jurisdictions have implemented reference drug programs (RDPs) or similar therapeutic substitution programs. This paper summarizes the mechanism and rationale of RDPs and presents evidence of their economic effectiveness and clinical safety. RDPs for pharmaceutical reimbursement are based on the assumption that drugs within specified medication groups are therapeutically equivalent and clinically interchangeable and that a common reimbursement level can thus be established. If the evidence documents that a higher price for a given drug does not buy greater effectiveness or reduced toxicity, then under RDP such extra costs are not covered. RDPs or therapeutic substitutions based on therapeutic equivalence are seen as logical extensions of generic substitution that is based on bioequivalence of drugs. If the goal is to achieve full drug coverage for as many patients as possible in the most efficient manner, then RDPs in combination with prior authorization programs are safer and more effective than simplistic fiscal drug policies, including fixed co-payments, co-insurances, or deductibles. RDPs will reduce spending in the less innovative but largest market, while fully covering all patients. Prior authorization will ensure that patients with a specified indication will benefit from the most innovative therapies with full coverage. In practice, however, not all patients and drugs will fit exactly into one of the two categories. Therefore, a process of medically indicated exemptions that will consider full coverage should accompany an RDP. In the current economic environment, health care systems are constantly struggling to contain rapidly rising costs. Drug costs are targeted by a wide variety of measures. Many jurisdictions have implemented reference drug programs, and others are considering

  3. The reorganization of a monographic reference collection.

    PubMed

    Jeuell, C A

    1976-07-01

    Reference monographs in the Health Sciences Library of the College of Medicine and Dentistry of New Jersey were reorganized recently according to form, in order to enable both librarians and patrons to utilize these materials more efficiently. This reorganization reflects the unique characteristics of reference books as differentiated from the regular monographic collection, since reference materials are frequently consulted for quick "look-ups." A reference category scheme was developed and implemented, based on observations of and comparisons with reference collections of eight medical libraries in the New York metropolitan area. The reorganization enhances the retrievability of materials from this collection. PMID:938775

  4. Standard Setting to an International Reference Framework: Implications for Theory and Practice

    ERIC Educational Resources Information Center

    Lim, Gad S.; Geranpayeh, Ardeshir; Khalifa, Hanan; Buckendahl, Chad W.

    2013-01-01

    Standard setting theory has largely developed with reference to a typical situation, determining a level or levels of performance for one exam for one context. However, standard setting is now being used with international reference frameworks, where some parameters and assumptions of classical standard setting do not hold. We consider the…

  5. Reference waste package environment report

    SciTech Connect

    Glassley, W.E.

    1986-10-01

    One of three candidate repository sites for high-level radioactive waste packages is located at Yucca Mountain, Nevada, in rhyolitic tuff 700 to 1400 ft above the static water table. Calculations indicate that the package environment will experience a maximum temperature of {similar_to}230{sup 0}C at 9 years after emplacement. For the next 300 years the rock within 1 m of the waste packages will remain dehydrated. Preliminary results suggest that the waste package radiation field will have very little effect on the mechanical properties of the rock. Radiolysis products will have a negligible effect on the rock even after rehydration. Unfractured specimens of repository rock show no change in hydrologic characteristics during repeated dehydration-rehydration cycles. Fractured samples with initially high permeabilities show a striking permeability decrease during dehydration-rehydration cycling, which may be due to fracture healing via deposition of silica. Rock-water interaction studies demonstrate low and benign levels of anions and most cations. The development of sorptive secondary phases such as zeolites and clays suggests that anticipated rock-water interaction may produce beneficial changes in the package environment.

  6. Reference data sets for testing metrology software

    NASA Astrophysics Data System (ADS)

    Kok, G. J. P.; Harris, P. M.; Smith, I. M.; Forbes, A. B.

    2016-08-01

    Many fields of metrology rely on calculations that are implemented in software. When such software is used to provide a measurement result, which is required to be traceable, it is necessary to recognise explicitly the software and show it to be operating correctly. An approach to testing the performance of calculation software is based on using reference pairs each of which comprises reference input data applied as input to the software and corresponding reference output data against which the output data of the software is compared. However, to make the reference pair useful for verifying and validating calculation software, information is needed about the numerical accuracy of the reference pair, the numerical sensitivity of the reference output data to perturbations in the reference input data, and the measurement uncertainty associated with the reference output data arising from simulated measurement uncertainty associated with the reference input data. Such information is important as a means to express quantitatively the quality of the reference pair as a numerical artefact to test calculation software, and as a basis for performance metrics to express quantitatively the numerical performance of software. In this paper these additional components of a reference data set are described, and various approaches to calculating them are discussed. An example, concerned with the calculation of the Gaussian (least-squares) best-fit plane to measured data, which is typical of calculations undertaken in coordinate metrology, is used to illustrate the ideas presented.

  7. REFERENCE CASES FOR USE IN THE CEMENTITOUS PARTNERSHIP PROJECT

    SciTech Connect

    Langton, C.; Kosson, D.; Garrabrants, A.

    2010-08-31

    The Cementitious Barriers Partnership Project (CBP) is a multi-disciplinary, multi-institution cross cutting collaborative effort supported by the US Department of Energy (DOE) to develop a reasonable and credible set of tools to improve understanding and prediction of the structural, hydraulic and chemical performance of cementitious barriers used in nuclear applications. The period of performance is >100 years for operating facilities and > 1000 years for waste management. The CBP has defined a set of reference cases to provide the following functions: (i) a common set of system configurations to illustrate the methods and tools developed by the CBP, (ii) a common basis for evaluating methodology for uncertainty characterization, (iii) a common set of cases to develop a complete set of parameter and changes in parameters as a function of time and changing conditions, (iv) a basis for experiments and model validation, and (v) a basis for improving conceptual models and reducing model uncertainties. These reference cases include the following two reference disposal units and a reference storage unit: (i) a cementitious low activity waste form in a reinforced concrete disposal vault, (ii) a concrete vault containing a steel high-level waste tank filled with grout (closed high-level waste tank), and (iii) a spent nuclear fuel basin during operation. Each case provides a different set of desired performance characteristics and interfaces between materials and with the environment. Examples of concretes, grout fills and a cementitious waste form are identified for the relevant reference case configurations.

  8. REFERENCE CASES FOR USE IN THE CEMENTITIOUS BARRIERS PARTNERSHIP

    SciTech Connect

    Langton, C

    2009-01-06

    The Cementitious Barriers Project (CBP) is a multidisciplinary cross cutting project initiated by the US Department of Energy (DOE) to develop a reasonable and credible set of tools to improve understanding and prediction of the structural, hydraulic and chemical performance of cementitious barriers used in nuclear applications. The period of performance is >100 years for operating facilities and > 1000 years for waste management. The CBP has defined a set of reference cases to provide the following functions: (1) a common set of system configurations to illustrate the methods and tools developed by the CBP, (2) a common basis for evaluating methodology for uncertainty characterization, (3) a common set of cases to develop a complete set of parameter and changes in parameters as a function of time and changing conditions, and (4) a basis for experiments and model validation, and (5) a basis for improving conceptual models and reducing model uncertainties. These reference cases include the following two reference disposal units and a reference storage unit: (1) a cementitious low activity waste form in a reinforced concrete disposal vault, (2) a concrete vault containing a steel high-level waste tank filled with grout (closed high-level waste tank), and (3) a spent nuclear fuel basin during operation. Each case provides a different set of desired performance characteristics and interfaces between materials and with the environment. Examples of concretes, grout fills and a cementitious waste form are identified for the relevant reference case configurations.

  9. Astrophysics of Reference Frame Tie Objects

    NASA Technical Reports Server (NTRS)

    Johnston, Kenneth J.; Boboltz, David; Fey, Alan Lee; Gaume, Ralph A.; Zacharias, Norbert

    2004-01-01

    The Astrophysics of Reference Frame Tie Objects Key Science program will investigate the underlying physics of SIM grid objects. Extragalactic objects in the SIM grid will be used to tie the SIM reference frame to the quasi-inertial reference frame defined by extragalactic objects and to remove any residual frame rotation with respect to the extragalactic frame. The current realization of the extragalactic frame is the International Celestial Reference Frame (ICRF). The ICRF is defined by the radio positions of 212 extragalactic objects and is the IAU sanctioned fundamental astronomical reference frame. This key project will advance our knowledge of the physics of the objects which will make up the SIM grid, such as quasars and chromospherically active stars, and relates directly to the stability of the SIM reference frame. The following questions concerning the physics of reference frame tie objects will be investigated.

  10. Importance of reference gene selection for articular cartilage mechanobiology studies

    PubMed Central

    Al-Sabah, A.; Stadnik, P.; Gilbert, S.J.; Duance, V.C.; Blain, E.J.

    2016-01-01

    Summary Objective Identification of genes differentially expressed in mechano-biological pathways in articular cartilage provides insight into the molecular mechanisms behind initiation and/or progression of osteoarthritis (OA). Quantitative PCR (qPCR) is commonly used to measure gene expression, and is reliant on the use of reference genes for normalisation. Appropriate validation of reference gene stability is imperative for accurate data analysis and interpretation. This study determined in vitro reference gene stability in articular cartilage explants and primary chondrocytes subjected to different compressive loads and tensile strain, respectively. Design The expression of eight commonly used reference genes (18s, ACTB, GAPDH, HPRT1, PPIA, RPL4, SDHA and YWHAZ) was determined by qPCR and data compared using four software packages (comparative delta-Ct method, geNorm, NormFinder and BestKeeper). Calculation of geometric means of the ranked weightings was carried out using RefFinder. Results Appropriate reference gene(s) for normalisation of mechanically-regulated transcript levels in articular cartilage tissue or isolated chondrocytes were dependent on experimental set-up. SDHA, YWHAZ and RPL4 were the most stable genes whilst glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and to a lesser extent Hypoxanthine-guanine phosphoribosyltransferase (HPRT), showed variable expression in response to load, demonstrating their unsuitability in such in vitro studies. The effect of using unstable reference genes to normalise the expression of aggrecan (ACAN) and matrix metalloproteinase 3 (MMP3) resulted in inaccurate quantification of these mechano-sensitive genes and erroneous interpretation/conclusions. Conclusion This study demonstrates that commonly used ‘reference genes’ may be unsuitable for in vitro cartilage chondrocyte mechanobiology studies, reinforcing the principle that careful validation of reference genes is essential prior to each experiment to

  11. In situ LTE exposure of the general public: Characterization and extrapolation.

    PubMed

    Joseph, Wout; Verloock, Leen; Goeminne, Francis; Vermeeren, Günter; Martens, Luc

    2012-09-01

    In situ radiofrequency (RF) exposure of the different RF sources is characterized in Reading, United Kingdom, and an extrapolation method to estimate worst-case long-term evolution (LTE) exposure is proposed. All electric field levels satisfy the International Commission on Non-Ionizing Radiation Protection (ICNIRP) reference levels with a maximal total electric field value of 4.5 V/m. The total values are dominated by frequency modulation (FM). Exposure levels for LTE of 0.2 V/m on average and 0.5 V/m maximally are obtained. Contributions of LTE to the total exposure are limited to 0.4% on average. Exposure ratios from 0.8% (LTE) to 12.5% (FM) are obtained. An extrapolation method is proposed and validated to assess the worst-case LTE exposure. For this method, the reference signal (RS) and secondary synchronization signal (S-SYNC) are measured and extrapolated to the worst-case value using an extrapolation factor. The influence of the traffic load and output power of the base station on in situ RS and S-SYNC signals are lower than 1 dB for all power and traffic load settings, showing that these signals can be used for the extrapolation method. The maximal extrapolated field value for LTE exposure equals 1.9 V/m, which is 32 times below the ICNIRP reference levels for electric fields.

  12. RIPS: a UNIX-based reference information program for scientists.

    PubMed

    Klyce, S D; Rózsa, A J

    1983-09-01

    A set of programs is described which implement a personal reference management and information retrieval system on a UNIX-based minicomputer. The system operates in a multiuser configuration with a host of user-friendly utilities that assist entry of reference material, its retrieval, and formatted printing for associated tasks. A search command language was developed without restriction in keyword vocabulary, number of keywords, or level of parenthetical expression nesting. The system is readily transported, and by design is applicable to any academic specialty.

  13. Triglyceride level

    MedlinePlus

    ... may also cause swelling of your pancreas (called pancreatitis). The triglyceride level is usually included in a ... lower triglyceride levels may be used to prevent pancreatitis for levels above 500 mg/dL Low triglyceride ...

  14. The need for new isotope reference materials.

    PubMed

    Vogl, Jochen; Rosner, Martin; Pritzkow, Wolfgang

    2013-03-01

    Isotope reference materials are needed to calibrate and validate analytical procedures used for the determination of isotope amount ratios, procedurally defined isotope ratios or so-called δ values. In contrast to the huge analytical progress in isotope ratio analytics, the production of isotope reference materials has not kept pace with the increasing needs of isotope analysts. Three representative isotope systems are used to explain the technical and non-technical difficulties and drawbacks, on one hand, and to demonstrate what can be achieved at its best, on the other hand. A clear statement is given that new isotope reference materials are needed to obtain traceable and thus comparable data, which is essential for all kinds of isotope research. The range of available isotope reference materials and δ reference materials should be increased and matrix reference materials certified for isotope compositions or δ values, which do not exist yet, should be provided.

  15. 40 CFR 94.5 - Reference materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reference as prescribed in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air...: Table 2 of § 94.5—ISO Materials Document No. and name 40 CFR part 94 reference ISO 8178-1, Reciprocating... name 40 CFR part 94 reference Resolution 2—Technical Code on Control of Emission of Nitrogen...

  16. Skinner's verbal behavior: A reference list

    PubMed Central

    Sundberg, Mark L.; Partington, James W.

    1982-01-01

    The language literature contains many citations to Skinner's book Verbal Behavior (1957), however, most of them are negative and generally unsupportive. The current list of references was assembled to bring readers in contact with the growing body of literature which supports Skinner's work. A total of 136 references were found and divided into two categories, (1) conceptual, and (2) experimental and applied. These references are presented in an effort to stimulate additional research in this important aspect of behavior analysis. PMID:22573391

  17. 40 CFR 94.5 - Reference materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reference as prescribed in 5 U.S.C. 552(a) and 1 CFR part 51. Anyone may inspect copies at the U.S. EPA, Air...: Table 2 of § 94.5—ISO Materials Document No. and name 40 CFR part 94 reference ISO 8178-1, Reciprocating... name 40 CFR part 94 reference Resolution 2—Technical Code on Control of Emission of Nitrogen...

  18. Bisphenol A polycarbonate as a reference material

    NASA Technical Reports Server (NTRS)

    Hilado, C. J.; Cumming, H. J.; Williams, J. B.

    1977-01-01

    Test methods require reference materials to standardize and maintain quality control. Various materials have been evaluated as possible reference materials, including a sample of bisphenol A polycarbonate without additives. Screening tests for relative toxicity under various experimental conditions were performed using male mice exposed to pyrolysis effluents over a 200-800 C temperature range. It was found that the bisphenol A polycarbonate served as a suitable reference material as it is available in large quantities, and does not significantly change with time.

  19. The NASA master directory: Quick reference guide

    NASA Technical Reports Server (NTRS)

    Satin, Karen (Editor); Kanga, Carol (Editor)

    1989-01-01

    This is a quick reference guide to the NASA Master Directory (MD), which is a free, online, multidisciplinary directory of space and Earth science data sets (NASA and non-NASA data) that are of potential interest to the NASA-sponsored research community. The MD contains high-level descriptions of data sets, other data systems and archives, and campaigns and projects. It provides mechanisms for searching for data sets by important criteria such as geophysical parameters, time, and spatial coverage, and provides information on ordering the data. It also provides automatic connections to a number of data systems such as the NASA Climate Data System, the Planetary Data System, the NASA Ocean Data System, the Pilot Land Data System, and others. The MD includes general information about many data systems, data centers, and coordinated data analysis projects, It represents the first major step in the Catalog Interoperability project, whose objective is to enable researchers to quickly and efficiently identify, obtain information about, and get access to space and Earth science data. The guide describes how to access, use, and exit the MD and lists its features.

  20. Astrometric reference stars: from UCAC to URAT

    NASA Astrophysics Data System (ADS)

    Zacharias, N.

    2004-10-01

    Currently available astrometric catalogs will be reviewed, and instrumentation and observational issues discussed, particularly systematic errors and their control. The U.S. Naval Observatory (USNO) CCD Astrograph Catalog (UCAC) is an all-sky astrometric survey to 16th magnitude. It was observed with a semi-automated telescope on a low budget. The second data release (July 2003) contains positions, proper motions, and photometry for over 48 million stars; the final release is expected in 2006. Design studies have been performed for a new 0.9-meter aperture USNO Robotic Astrometric Telescope (URAT) with a single chip (≥ 100 Mpixel), 3 degree FOV and circular symmetric pupil. Its operation is envisioned to be fully automatic, generating stellar positions on the 5 to 10 mas level to at least 18th magnitude with a limiting magnitude of about 20 to 21. These reference stars, being on an inertial system (linked to quasars), will be very beneficial for LSST, PanSTARRS and other projects. With a few years of observing, absolute trigonometric parallaxes (5-20 mas, depending on magnitude) could be obtained for all stars accessible by URAT from an initially southern hemisphere location.

  1. Generating Ground Reference Data for a Global Impervious Surface Survey

    NASA Technical Reports Server (NTRS)

    Tilton, James C.; De Colstoun, Eric Brown; Wolfe, Robert E.; Tan, Bin; Huang, Chengquan

    2012-01-01

    We are developing an approach for generating ground reference data in support of a project to produce a 30m impervious cover data set of the entire Earth for the years 2000 and 2010 based on the Landsat Global Land Survey (GLS) data set. Since sufficient ground reference data for training and validation is not available from ground surveys, we are developing an interactive tool, called HSegLearn, to facilitate the photo-interpretation of 1 to 2 m spatial resolution imagery data, which we will use to generate the needed ground reference data at 30m. Through the submission of selected region objects and positive or negative examples of impervious surfaces, HSegLearn enables an analyst to automatically select groups of spectrally similar objects from a hierarchical set of image segmentations produced by the HSeg image segmentation program at an appropriate level of segmentation detail, and label these region objects as either impervious or nonimpervious.

  2. Preserving sequence annotations across reference sequences

    PubMed Central

    2014-01-01

    Background Matching and comparing sequence annotations of different reference sequences is vital to genomics research, yet many annotation formats do not specify the reference sequence types or versions used. This makes the integration of annotations from different sources difficult and error prone. Results As part of our effort to create linked data for interoperable sequence annotations, we present an RDF data model for sequence annotation using the ontological framework established by the OBO Foundry ontologies and the Basic Formal Ontology (BFO). We defined reference sequences as the common domain of integration for sequence annotations, and identified three semantic relationships between sequence annotations. In doing so, we created the Reference Sequence Annotation to compensate for gaps in the SO and in its mapping to BFO, particularly for annotations that refer to versions of consensus reference sequences. Moreover, we present three integration models for sequence annotations using different reference assemblies. Conclusions We demonstrated a working example of a sequence annotation instance, and how this instance can be linked to other annotations on different reference sequences. Sequence annotations in this format are semantically rich and can be integrated easily with different assemblies. We also identify other challenges of modeling reference sequences with the BFO. PMID:25093075

  3. Resources and References for Earth Science Teachers

    ERIC Educational Resources Information Center

    Wall, Charles A.; Wall, Janet E.

    1976-01-01

    Listed are resources and references for earth science teachers including doctoral research, new textbooks, and professional literature in astronomy, space science, earth science, geology, meteorology, and oceanography. (SL)

  4. Assessment of induced SAR in children exposed to electromagnetic plane waves between 10 MHz and 5.6 GHz

    NASA Astrophysics Data System (ADS)

    Bakker, J. F.; Paulides, M. M.; Christ, A.; Kuster, N.; van Rhoon, G. C.

    2010-06-01

    To avoid potentially adverse health effects of electromagnetic fields (EMF), the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined EMF reference levels from the basic restrictions on the induced whole-body-averaged specific absorption rate (SARwb) and the peak 10 g spatial-averaged SAR (SAR10g). The objective of this study is to assess if the SAR in children remains below the basic restrictions upon exposure at the reference levels. Finite difference time domain (FDTD) modeling was used to calculate the SAR in six children and two adults when exposed to all 12 orthogonal plane wave configurations. A sensitivity study showed an expanded uncertainty of 53% (SARwb) and 58% (SAR10g) due to variations in simulation settings and tissue properties. In this study, we found that the basic restriction on the SARwb is occasionally exceeded for children, up to a maximum of 45% in small children. The maximum SAR10g values, usually found at body protrusions, remain under the limit for all scenarios studied. Our results are in good agreement with the literature, suggesting that the recommended ICNIRP reference levels may need fine tuning.

  5. Assessment of induced SAR in children exposed to electromagnetic plane waves between 10 MHz and 5.6 GHz.

    PubMed

    Bakker, J F; Paulides, M M; Christ, A; Kuster, N; van Rhoon, G C

    2010-06-01

    To avoid potentially adverse health effects of electromagnetic fields (EMF), the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined EMF reference levels from the basic restrictions on the induced whole-body-averaged specific absorption rate (SAR(wb)) and the peak 10 g spatial-averaged SAR (SAR(10g)). The objective of this study is to assess if the SAR in children remains below the basic restrictions upon exposure at the reference levels. Finite difference time domain (FDTD) modeling was used to calculate the SAR in six children and two adults when exposed to all 12 orthogonal plane wave configurations. A sensitivity study showed an expanded uncertainty of 53% (SAR(wb)) and 58% (SAR(10g)) due to variations in simulation settings and tissue properties. In this study, we found that the basic restriction on the SAR(wb) is occasionally exceeded for children, up to a maximum of 45% in small children. The maximum SAR(10g) values, usually found at body protrusions, remain under the limit for all scenarios studied. Our results are in good agreement with the literature, suggesting that the recommended ICNIRP reference levels may need fine tuning.

  6. Selection of reference genes in canine uterine tissues.

    PubMed

    Du, M; Wang, X; Yue, Y W; Zhou, P Y; Yao, W; Li, X; Ding, X B; Liu, X F; Guo, H; Ma, W Z

    2016-01-01

    Real-time quantitative polymerase chain reaction (RT-qPCR) is usually employed in gene expression studies in veterinary research, including in studies on canine pyometra. Canine pyometra is a common clinical disease in bitches. When using RT-qPCR, internal standards, such as reference genes, are necessary to investigate relative gene expression by quantitative measurements of mRNA levels. The aim of this study was to evaluate the stability of reference genes and select reference genes suitable for canine pyometra studies. We collected 24 bitch uterine tissue samples, including five healthy and 19 pyometra infected samples. These were used to screen the best reference genes of seven candidate genes (18SrRNA, ACTB, B2M, GAPDH, HPRT, RPL13A, and YWHAZ). The method of KH Sadek and the GeNorm, Normfinder, BestKeeper, and RefFinder software were used to evaluate the stability of gene expression in both pyometra and healthy uterine samples. The results showed that the expression stability of the candidate gene in pyometra and healthy tissues differed. We showed that YWHAZ was the best reference gene, which could be used as an accurate internal control gene in canine pyometra studies. To further validate this recommendation, the expression profile of a target gene insulin-like growth factor 1 receptor gene (IGF1R) was investigated. We found that the expression of IGF1R was significantly altered when different reference genes were used. All reference genes identified in the present study will enable more accurate normalization of gene expression data in both pyometra infected and healthy uterine tissues. PMID:27323194

  7. Blood plasma reference material: a global resource for proteomic research.

    PubMed

    Malm, Johan; Danmyr, Pia; Nilsson, Rolf; Appelqvist, Roger; Végvári, Akos; Marko-Varga, György

    2013-07-01

    There is an ever-increasing awareness and interest within the clinical research field, creating a large demand for blood fraction samples as well as other clinical samples. The translational research area is another field that is demanding for blood samples, used widely in proteomics, genomics, as well as metabolomics. Blood samples are globally the most common biological samples that are used in a broad variety of applications in life science. We hereby introduce a new reference blood plasma standard (heparin) that is aimed as a global resource for the proteomics community. We have developed these reference plasma standards by defining the Control group as those with C-reactive protein levels <3 mg/L and a Disease group with C-reactive protein ranges >30 mg/L. In these references we have used both newborn children 1-2 weeks, as well as youngsters 15-30 years, and middle aged 30-50 years, and elderly patients at the ages of 65+. In total, there were 80 patients in each group in the reference plasma pools. We provide data on the developments and characteristics of the reference blood plasma standards, as well as what is used by the team members at the respective laboratories. The standards have been evaluated by pilot sample processing in biobanking operations and are currently a resource that allows the Proteomic society to perform quantitative proteomic studies. By the use of high quality reference plasma samples, global initiatives, such as the Chromosome Human Proteome Project (C-HPP), will benefit as one scientific program when the entire human proteome is mapped and linked to human diseases. The plasma reference standards are a global resource and can be accessed upon request. PMID:23701512

  8. The equations of relative motion in the orbital reference frame

    NASA Astrophysics Data System (ADS)

    Casotto, Stefano

    2016-03-01

    of the node and the argument of perigee, i.e., of the entire orbital plane. Here we provide a derivation of the exact equations of relative motion by expressing the angular velocity of the RTN frame in terms of the state vector of the reference spacecraft. As such, these equations are completely general, in the sense that the orbit of the reference spacecraft need only be known through its ephemeris, and therefore subject to any force field whatever. It is also shown that these equations reduce to either the Hill-Clohessy-Wiltshire, or the Tschauner-Hempel equations, depending on the level of approximation. The explicit form of the equations of relative motion with respect to a J_2-perturbed reference orbit is also introduced.

  9. A First Look at the Upcoming SISO Space Reference FOM

    NASA Technical Reports Server (NTRS)

    Crues, Edwin; Dexter, Dan; Madden, Michael; Garro, Alfred; Vankov, Alexander; Skuratovskiy, Anton; Moller, Bjorn

    2016-01-01

    Simulation is increasingly used in the space domain for several purposes. One example is analysis and engineering, from the mission level down to individual systems and subsystems. Another example is training of space crew and flight controllers. Several distributed simulations have been developed for example for docking vehicles with the ISS and for mission training, in many cases with participants from several nations. Space based scenarios are also used in the "Simulation Exploration Experience", SISO's university outreach program. We have thus realized that there is a need for a distributed simulation interoperability standard for data exchange within the space domain. Based on these experiences, SISO is developing a Space Reference FOM. Members of the product development group come from several countries and contribute experiences from projects within NASA, ESA and other organizations. Participants represent government, academia and industry. The first version will focus on handling of time and space. The Space Reference FOM will provide the following: (i) a flexible positioning system using reference frames for arbitrary bodies in space, (ii) a naming conventions for well known reference frames, (iii) definitions of common time scales, (iv) federation agreements for common types of time management with focus on time stepped simulation, and (v) support for physical entities, such as space vehicles and astronauts. The Space Reference FOM is expected to make collaboration politically, contractually and technically easier. It is also expected to make collaboration easier to manage and extend.

  10. CRYSTALLINE CERAMIC WASTE FORMS: REFERENCE FORMULATION REPORT

    SciTech Connect

    Brinkman, K.; Fox, K.; Marra, J.

    2012-05-15

    The research conducted in this work package is aimed at taking advantage of the long term thermodynamic stability of crystalline ceramics to create more durable waste forms (as compared to high level waste glass) in order to reduce the reliance on engineered and natural barrier systems. Durable ceramic waste forms that incorporate a wide range of radionuclides have the potential to broaden the available disposal options and to lower the storage and disposal costs associated with advanced fuel cycles. Assemblages of several titanate phases have been successfully demonstrated to incorporate radioactive waste elements, and the multiphase nature of these materials allows them to accommodate variation in the waste composition. Recent work has shown that they can be successfully produced from a melting and crystallization process. The objective of this report is to explain the design of ceramic host systems culminating in a reference ceramic formulation for use in subsequent studies on process optimization and melt property data assessment in support of FY13 melter demonstration testing. The waste stream used as the basis for the development and testing is a combination of the projected Cs/Sr separated stream, the Trivalent Actinide - Lanthanide Separation by Phosphorous reagent Extraction from Aqueous Komplexes (TALSPEAK) waste stream consisting of lanthanide fission products, the transition metal fission product waste stream resulting from the transuranic extraction (TRUEX) process, and a high molybdenum concentration with relatively low noble metal concentrations. In addition to the combined CS/LN/TM High Mo waste stream, variants without Mo and without Mo and Zr were also evaluated. Based on the results of fabricating and characterizing several simulated ceramic waste forms, two reference ceramic waste form compositions are recommended in this report. The first composition targets the CS/LN/TM combined waste stream with and without Mo. The second composition targets

  11. Getting Things Right at the Classroom Level

    ERIC Educational Resources Information Center

    Shaw, Jerome M.

    2005-01-01

    In this article, the author approaches accountability testing from a more micro level and offers a response to the question, "What can be done to get assessment right at the classroom level?" The author's answer refers back to accountability issues by considering that class of assessments most commonly used for such a purpose, herein referred to…

  12. 40 CFR 90.7 - Reference materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA Air and Radiation... 19103. Document number and name 40 CFR part 90 reference ASTM D86-93: Standard Test Method for...., Warrendale, PA 15096-0001. Document number and name 40 CFR part 90 reference SAE J1930 September...

  13. 40 CFR 90.7 - Reference materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA Air and Radiation... 19103. Document number and name 40 CFR part 90 reference ASTM D86-93: Standard Test Method for...., Warrendale, PA 15096-0001. Document number and name 40 CFR part 90 reference SAE J1930 September...

  14. 40 CFR 91.6 - Reference materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA, OAR, Air and Radiation Docket and... 19103. Document number and name 40 CFR part 91 reference ASTM D86-93: Standard Test Method for... 40 CFR part 91 reference SAE J1228/ISO 8665 November 1991 Small Craft-Marine Propulsion Engine...

  15. 40 CFR 91.6 - Reference materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA, OAR, Air and Radiation Docket and... 19103. Document number and name 40 CFR part 91 reference ASTM D86-93: Standard Test Method for... 40 CFR part 91 reference SAE J1228/ISO 8665 November 1991 Small Craft-Marine Propulsion Engine...

  16. 40 CFR 91.6 - Reference materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA, OAR, Air and Radiation Docket and... 19103. Document number and name 40 CFR part 91 reference ASTM D86-93: Standard Test Method for... 40 CFR part 91 reference SAE J1228/ISO 8665 November 1991 Small Craft-Marine Propulsion Engine...

  17. 40 CFR 90.7 - Reference materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA Air and Radiation... 19103. Document number and name 40 CFR part 90 reference ASTM D86-93: Standard Test Method for...., Warrendale, PA 15096-0001. Document number and name 40 CFR part 90 reference SAE J1930 September...

  18. 40 CFR 90.7 - Reference materials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA Air and Radiation... 19103. Document number and name 40 CFR part 90 reference ASTM D86-93: Standard Test Method for...., Warrendale, PA 15096-0001. Document number and name 40 CFR part 90 reference SAE J1930 September...

  19. 40 CFR 92.5 - Reference materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected...., Philadelphia, PA 19103. The table follows: Document number and name 40 CFR part 92 reference ASTM D 86-95... follows: Document number and name 40 CFR part 92 reference SAE Paper 770141, Optimization of a...

  20. 40 CFR 91.6 - Reference materials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA, OAR, Air and Radiation Docket and... 19103. Document number and name 40 CFR part 91 reference ASTM D86-93: Standard Test Method for... 40 CFR part 91 reference SAE J1228/ISO 8665 November 1991 Small Craft-Marine Propulsion Engine...

  1. 40 CFR 90.7 - Reference materials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA Air and Radiation... 19103. Document number and name 40 CFR part 90 reference ASTM D86-93: Standard Test Method for...., Warrendale, PA 15096-0001. Document number and name 40 CFR part 90 reference SAE J1930 September...

  2. 40 CFR 92.5 - Reference materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be inspected...., Philadelphia, PA 19103. The table follows: Document number and name 40 CFR part 92 reference ASTM D 86-95... follows: Document number and name 40 CFR part 92 reference SAE Paper 770141, Optimization of a...

  3. 40 CFR 91.6 - Reference materials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...(a) and 1 CFR part 51. Copies may be inspected at U.S. EPA, OAR, Air and Radiation Docket and... 19103. Document number and name 40 CFR part 91 reference ASTM D86-93: Standard Test Method for... 40 CFR part 91 reference SAE J1228/ISO 8665 November 1991 Small Craft-Marine Propulsion Engine...

  4. Old Testament biblical references to tuberculosis.

    PubMed

    Daniel, V S; Daniel, T M

    1999-12-01

    Two probable references to tuberculosis are found in Old Testament books of the Bible dating to a time when the Israelites lived in Egypt, which is known from archeological evidence to be an area where tuberculosis was then prevalent. Other putative biblical references to tuberculosis are less credible.

  5. Referent Salience Affects Second Language Article Use

    ERIC Educational Resources Information Center

    Trenkic, Danijela; Pongpairoj, Nattama

    2013-01-01

    The effect of referent salience on second language (L2) article production in real time was explored. Thai (-articles) and French (+articles) learners of English described dynamic events involving two referents, one visually cued to be more salient at the point of utterance formulation. Definiteness marking was made communicatively redundant with…

  6. Partners in Learning, or Reference Service Unplugged.

    ERIC Educational Resources Information Center

    Pereira, Monica

    Traditional reference service at the Creighton University Health Sciences Library/Learning Resources Center has been transformed into a vibrant, information dissemination system. Maintaining routine reference skills and developing new ones is standard practice. The furious pace of demand for information, and the growing "technicalness" of…

  7. 44 CFR 59.4 - References.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... INSURANCE AND HAZARD MITIGATION National Flood Insurance Program GENERAL PROVISIONS General § 59.4 References. (a) The following are statutory references for the National Flood Insurance Program, under which these regulations are issued: (1) National Flood Insurance Act of 1968 (title XIII of the Housing...

  8. Color, Reference, and Expertise in Language Acquisition

    ERIC Educational Resources Information Center

    Clark, Eve V.

    2006-01-01

    In learning the meaning of a new term, children need to fix its reference, learn its conventional meaning, and discover the meanings with which it contrasts. To do this, children must attend to adult speakers--the experts--and to their patterns of use. In the domain of color, children need to identify color terms as such, fix the reference of each…

  9. Reference Service: A Field with a View.

    ERIC Educational Resources Information Center

    McCann, Linda; Wallach, Ruth

    1999-01-01

    Discusses new technologies and the value of one-on-one personalized interaction in the reference environment and reports results of an informal survey of practitioners that investigated their views on the influences of theoretical models and new technologies on reference service. Highlights include collection development; interpersonal relations;…

  10. 47 CFR 15.605 - Cross reference.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Cross reference. 15.605 Section 15.605 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Access Broadband Over Power Line (Access BPL) § 15.605 Cross reference. (a) The provisions of subparts A and B of this part apply to...

  11. 47 CFR 15.605 - Cross reference.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Cross reference. 15.605 Section 15.605 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Access Broadband Over Power Line (Access BPL) § 15.605 Cross reference. (a) The provisions of subparts A and B of this part apply to...

  12. On Vague Reference in College English

    ERIC Educational Resources Information Center

    Ma, Jianhe

    2011-01-01

    We often come across examples of vague reference in English learning, especially college English learning. On entering college, students tend to feel at a loss since their vocabulary is required to be enlarged rapidly and a variety of reference patterns are included in their learning materials which mostly come from American and European original…

  13. Reflections on Malpractice of Reference Librarians.

    ERIC Educational Resources Information Center

    Wan, Ronglin

    1994-01-01

    Explores the legal ramifications of malpractice among librarians and the possible impact on services due to fear of being sued. Topics include identification of potential malpractice areas; cooperative electronic reference services; use of reference standards; insurance; contract; disclaimer; updating library collections; using Internet resources;…

  14. 32 CFR 516.2 - References.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true References. 516.2 Section 516.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION General § 516.2 References. Applicable publications and forms are listed in appendix A to...

  15. Spatial reference in multiple object tracking.

    PubMed

    Jahn, Georg; Papenmeier, Frank; Meyerhoff, Hauke S; Huff, Markus

    2012-01-01

    Spatial reference in multiple object tracking is available from configurations of dynamic objects and static reference objects. In three experiments, we studied the use of spatial reference in tracking and in relocating targets after abrupt scene rotations. Observers tracked 1, 2, 3, 4, and 6 targets in 3D scenes, in which white balls moved on a square floor plane. The floor plane was either visible thus providing static spatial reference or it was invisible. Without scene rotations, the configuration of dynamic objects provided sufficient spatial reference and static spatial reference was not advantageous. In contrast, with abrupt scene rotations of 20°, static spatial reference supported in relocating targets. A wireframe floor plane lacking local visual detail was as effective as a checkerboard. Individually colored geometric forms as static reference objects provided no additional benefit either, even if targets were centered on these forms at the abrupt scene rotation. Individualizing the dynamic objects themselves by color for a brief interval around the abrupt scene rotation, however, did improve performance. We conclude that attentional tracking of moving targets proceeds within dynamic configurations but detached from static local background.

  16. Going Prime Time with Live Chat Reference.

    ERIC Educational Resources Information Center

    Hoag, Tara J.; Cichanowicz, Edana McCaffrey

    2001-01-01

    Describes the development of the Suffolk Cooperative Library System's live, online chat reference service, a pilot project for public libraries in Suffolk County (New York). Topics include chat software selection; a virtual reference collection; marketing; funding; staffing; evaluation; expanded hours of service; email; and extracting data from…

  17. 23 CFR 650.317 - Reference manuals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...(a) and 1 CFR part 51. These materials are incorporated as they exist on the date of the approval... 23 Highways 1 2010-04-01 2010-04-01 false Reference manuals. 650.317 Section 650.317 Highways..., STRUCTURES, AND HYDRAULICS National Bridge Inspection Standards § 650.317 Reference manuals. (a)...

  18. 47 CFR 15.405 - Cross reference.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Cross reference. 15.405 Section 15.405 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed National Information Infrastructure Devices § 15.405 Cross reference. (a) The provisions of subparts A, B, and C of this part apply...

  19. 47 CFR 15.405 - Cross reference.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Cross reference. 15.405 Section 15.405 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed National Information Infrastructure Devices § 15.405 Cross reference. (a) The provisions of subparts A, B, and C of this part apply...

  20. 47 CFR 15.405 - Cross reference.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Cross reference. 15.405 Section 15.405 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed National Information Infrastructure Devices § 15.405 Cross reference. (a) The provisions of subparts A, B, and C of this part apply...