Sample records for icr numbers epa
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-19
... . FOR FURTHER INFORMATION CONTACT: Rachel Lentz, Office of Brownfields and Land Revitalization, (5105T.... Title: Brownfields Program--Accomplishment Reporting (Renewal). ICR numbers: EPA ICR No. 2104.04, OMB... and Brownfields Revitalization Act (Pub. L. 107-118) (``the Brownfields Amendments'') was signed into...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-04
... Item Specific ICR Titles Provided in the Text AGENCY: Environmental Protection Agency (EPA). ACTION... request (ICR) (See item specific ICR title, EPA ICR Number, and OMB Control Number provided in the text... additional comments to OMB. (1) Docket ID Number: EPA-HQ-OECA-2013-0337; Title: NESHAP for Portland Cement...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-11
...; See Item Specific ICR Titles Provided in the Text AGENCY: Environmental Protection Agency (EPA... collection request (ICR) (See item specific ICR title, EPA ICR Number, and OMB Control Number provided in the... opportunity to submit additional comments to OMB. (1) Docket ID Number: EPA-HQ-OECA-2013-0303; Title: NSPS for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-22
... Program, OMB Control No. 2060-0350 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY.... 1774.05, OMB Control No. 2060-0350. ICR status: This ICR is currently scheduled to expire on July 31...
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On March 31, 2011, U.S. EPA sent a Section 114 letter to the BP-Husky Refining Company in Oregon, Ohio stating that the facility was subject to the ICR and that certain information would need to be submitted by the facility to satisfy U.S. EPA’s ICR.
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40 CFR 262.12 - EPA identification numbers.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 26 2014-07-01 2014-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...
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40 CFR 262.12 - EPA identification numbers.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 25 2010-07-01 2010-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...
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40 CFR 262.12 - EPA identification numbers.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 27 2012-07-01 2012-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...
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40 CFR 262.12 - EPA identification numbers.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 27 2013-07-01 2013-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...
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40 CFR 262.12 - EPA identification numbers.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 26 2011-07-01 2011-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...
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40 CFR 263.11 - EPA identification number.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 27 2013-07-01 2013-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...
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40 CFR 263.11 - EPA identification number.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 27 2012-07-01 2012-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...
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40 CFR 263.11 - EPA identification number.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 25 2010-07-01 2010-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...
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40 CFR 263.11 - EPA identification number.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 26 2014-07-01 2014-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...
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40 CFR 263.11 - EPA identification number.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 26 2011-07-01 2011-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...
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40 CFR 761.202 - EPA identification numbers.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 31 2011-07-01 2011-07-01 false EPA identification numbers. 761.202... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA...
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40 CFR 761.202 - EPA identification numbers.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 31 2014-07-01 2014-07-01 false EPA identification numbers. 761.202... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA...
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40 CFR 761.202 - EPA identification numbers.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 32 2013-07-01 2013-07-01 false EPA identification numbers. 761.202... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA...
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40 CFR 761.202 - EPA identification numbers.
Code of Federal Regulations, 2010 CFR
2010-07-01
... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA identification number under this subpart must notify EPA of his/her PCB waste handling activities, using the...
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40 CFR 761.202 - EPA identification numbers.
Code of Federal Regulations, 2012 CFR
2012-07-01
... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any... identification number from EPA. (4) A disposer of PCB waste shall not accept any PCB waste for disposal without... disposal facility or mobile treatment unit shall not accept waste unless the disposer has received an EPA...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-21
... Recovery Operations (Renewal), EPA ICR Number 1717.07, OMB Control Number 2060-0313 AGENCY: Environmental... Operations (Renewal). ICR Numbers: EPA ICR Number 1717.07, OMB Control Number 2060-0313. ICR Status: This ICR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
... Plant Incineration (Renewal), EPA ICR Number 1063.11, OMB Control Number 2060-0035 AGENCY: Environmental... Incineration (Renewal). ICR Numbers: EPA ICR Number 1063.11, OMB Control Number 2060-0035. ICR Status: This ICR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-10
... Manufacturing (Renewal), EPA ICR Number 2115.03, OMB Control Number 2060-0535 AGENCY: Environmental Protection... (Renewal) ICR Numbers: EPA ICR Number 2115.03, OMB Control Number 2060-0535. ICR Status: This ICR is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-08
... Plants, and Ferroalloy Production Facilities, (Renewal) EPA ICR Number 1604.09, OMB Control Number 2060... (Renewal) ICR Numbers: EPA ICR Number 1604.09, OMB Control Number 2060-0110. ICR Status: This ICR is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-14
... (Renewal), EPA ICR Number 1158.10, OMB Control Number 2060-0156 AGENCY: Environmental Protection Agency... Manufacturing (Renewal). ICR Numbers: EPA ICR Number 1158.10, OMB Control Number 2060-0156. ICR Status: This ICR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-14
... Cleaners (Renewal), EPA ICR Number 1652.07, OMB Control Number 2060- 0273 AGENCY: Environmental Protection...). ICR Numbers: EPA ICR Number 1652.07, OMB Control Number 2060-0273. ICR Status: This ICR is scheduled...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-16
... Product (Renewal), EPA ICR Number 1783.05, OMB Control Number 2060-0357 AGENCY: Environmental Protection... (Renewal). ICR Numbers: EPA ICR Number 1783.05, OMB Control Number 2060-0357. ICR Status: This ICR is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-08
... Parts for Business Machines, EPA ICR Number 1093.09, OMB Control Number 2060-0162 AGENCY: Environmental... Machines ICR Numbers: EPA ICR Number 1093.09, OMB Control Number 2060-0162. ICR Status: This ICR is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-27
... Surface Coating (Renewal), EPA ICR Number 2079.04, OMB Control Number 2060-0541 AGENCY: Environmental... Manufacturing Surface Coating (Renewal). ICR Numbers: EPA ICR Number 2079.04, OMB Control Number 2060-0541. ICR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-04
... (Renewal), EPA ICR Number 2098.05, OMB Control Number 2060- 0536 AGENCY: Environmental Protection Agency... Magnesium Refining (Renewal). ICR Numbers: EPA ICR Number 2098.05, OMB Control Number 2060-0536. ICR Status...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-02
... 264, Subpart CC and 40 CFR Part 265). ICR Numbers: EPA ICR Number 1593.08, OMB Control Number 2060... ICR Number 1593.08, OMB Control Number 2060-0318; expiration date October 31, 2010. (6) NESHAP for..., subpart CC and 40 CFR part 265), Docket ID Number: EPA-HQ-OECA-2010-0370, EPA ICR Number 1593.08, OMB...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-10
... (Renewal), EPA ICR Number 1078.09, OMB Control Number 2060-0111 AGENCY: Environmental Protection Agency... Numbers: EPA ICR Number 1078.09, OMB Control Number 2060-0111. ICR Status: This ICR is scheduled to expire...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-08
... (Renewal); EPA ICR Number 1128.09, OMB Control Number 2060-0080 AGENCY: Environmental Protection Agency... Numbers: EPA ICR Number 1128.09, OMB Control Number 2060-0080. ICR Status: This ICR is scheduled to expire...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-02
... Part 63, Subpart LLL), EPA ICR Number 1801.08, OMB Control Number 2060-0416 AGENCY: Environmental... Numbers: EPA ICR Number 1801.08, OMB Control Number 2060-0416. ICR Status: This ICR is scheduled to expire...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-13
... ICR Number 1058.10, OMB Control Number 2060-0040 AGENCY: Environmental Protection Agency (EPA). ACTION...: EPA ICR Number 1058.10, OMB Control Number 2060-0040. ICR Status: This ICR is scheduled to expire on...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-10
...-Institutional Steam Generating Units (Renewal), EPA ICR Number 1564.08, OMB Control Number 2060-0202 AGENCY...: EPA ICR Number 1564.08, OMB Control Number 2060-0202. ICR Status: This ICR is scheduled to expire on...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-23
... Importation of Nonconforming Vehicles (Renewal); EPA ICR No. 0010.12, OMB Control No. 2060-0095 AGENCY... (Renewal). ICR Numbers: EPA ICR Number 0010.12, OMB Control No. 2060-0095. ICR Status: This ICR is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-10
... ICR Number 0193.10, OMB Control Number 2060-0092 AGENCY: Environmental Protection Agency (EPA). ACTION... . Title: NESHAP for Beryllium (Renewal). ICR Numbers: EPA ICR Number 0193.10, OMB Control Number 2060-0092...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-20
... (Renewal), EPA ICR Number 1643.07, OMB Control Number 2060-0264 AGENCY: Environmental Protection Agency..., Local, and Tribal Agencies (Renewal). ICR Numbers: EPA ICR Number 1643.07, OMB Control Number 2060-0264...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-15
... Nonferrous Metals--Zinc, Cadmium, and Beryllium (Renewal); EPA ICR Number 2240.03, OMB Control Number 2060...--Zinc, Cadmium, and Beryllium (Renewal). ICR Numbers: EPA ICR Number 2240.03, OMB Control Number 2060...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
....07, OMB Control Number 2060-0327 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Anodizing Tanks (Renewal). ICR Numbers: EPA ICR Number 1611.07, OMB Control Number 2060-0327. ICR Status...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-26
...); EPA ICR No. 2400.01 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In... numbers: EPA ICR No. 2400.01. ICR status: This ICR is for a new information collection activity. An Agency...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-08
... Protocol Gas Verification Program; EPA ICR No. 2375.01, OMB Control Number 2060-NEW AGENCY: Environmental... Air Protocol Gas Verification Program. ICR numbers: EPA ICR No. 2375.01, OMB Control No. 2060-NEW. ICR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-23
... Risk and Technology Review; EPA ICR No. 2393.01, OMB Control Number 2060-NEW AGENCY: Environmental...) Residual Risk and Technology Review (RTR). ICR numbers: EPA ICR Number 2393.01, OMB Control Number 2060-NEW...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-03
... Manufacturers; EPA ICR No. 0309.13, OMB Control No. 2060-0150 AGENCY: Environmental Protection Agency (EPA... numbers: EPA ICR No. 0309.13, OMB Control No. 2060-0150. ICR status: This ICR is currently scheduled to...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-10
... 2060-0451 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with... Numbers: EPA ICR Number 1927.05, OMB Control Number 2060-0451. ICR Status: This ICR is scheduled to expire...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-08
... Production; EPA ICR Number 1788.09, OMB Control Number 2060-0417 AGENCY: Environmental Protection Agency (EPA... Control Number 2060-0388. ICR Status: This ICR is schedule to expire on February 28, 2010. Under OMB...
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Kim, Ji Eun; Nam, Jung Hoon; Cho, Joon Young; Kim, Kil Soo; Hwang, Dae Youn
2017-06-01
Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agriculture-fishery, and art-kinesiology fields by analyzing big data. Numbers of ICR mouse-used papers gradually increased from 1961 to 2014, but small decreases were observed in 2015 and 2016. The largest number of ICR-used papers were published in the medicine-pharmacy field, followed by natural science and art-kinesiology fields. There were no ICR mouse-used papers in other fields. Furthermore, ICR mice have been widely employed in cell biology studies within the natural science field as well as in biochemistry and pathology in the medicine-pharmacy field. Few ICR mouse-used papers were published in exercise biochemistry and exercise nutrition in the art-kinesiology field. Regardless in most fields, the total numbers of published papers involving ICR mice were higher in 2014 than in other years, although the numbers in some fields including dentistry, veterinary science, and dermatology were high in 2016. Taken together, the present study shows that various ICR stocks, including Korl:ICR mice, are widely employed as experimental animals in various biomedical research fields.
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Kim, Ji Eun; Nam, Jung Hoon; Cho, Joon Young; Kim, Kil Soo
2017-01-01
Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agriculture-fishery, and art-kinesiology fields by analyzing big data. Numbers of ICR mouse-used papers gradually increased from 1961 to 2014, but small decreases were observed in 2015 and 2016. The largest number of ICR-used papers were published in the medicine-pharmacy field, followed by natural science and art-kinesiology fields. There were no ICR mouse-used papers in other fields. Furthermore, ICR mice have been widely employed in cell biology studies within the natural science field as well as in biochemistry and pathology in the medicine-pharmacy field. Few ICR mouse-used papers were published in exercise biochemistry and exercise nutrition in the art-kinesiology field. Regardless in most fields, the total numbers of published papers involving ICR mice were higher in 2014 than in other years, although the numbers in some fields including dentistry, veterinary science, and dermatology were high in 2016. Taken together, the present study shows that various ICR stocks, including Korl:ICR mice, are widely employed as experimental animals in various biomedical research fields. PMID:28747984
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-25
... Large Household and Commercial Appliances (Renewal) AGENCY: Environmental Protection Agency (EPA... Commercial Appliances (Renewal). ICR Numbers: EPA ICR Number 1954.05, OMB Control Number 2060-0457. ICR... household and commercial appliances facilities. Estimated Number of Respondents: 102. Frequency of Response...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-22
... Provisions (Renewal); EPA ICR No. 2228.03, OMB Control No. 2060-0587 AGENCY: Environmental Protection Agency... (Renewal). ICR Numbers: EPA ICR No. 2228.03, OMB Control No. 2060-0566. ICR Status: This ICR is scheduled...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-27
... Works (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance... Treatment Works (Renewal). ICR Numbers: EPA ICR Number 1891.06, OMB Control Number 2060-0428. ICR Status... operators of publicly owned treatment works. Estimated Number of Respondents: 6. Frequency of Response...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-09
... Internal Combustion Engines (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Combustion Engines (Renewal) ICR Numbers: EPA ICR Number 2227.03, OMB Control Number 2060-0610. ICR Status... internal combustion engines. Estimated Number of Respondents: 17,052. Frequency of Response: Initially and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-09
... Refinery Wastewater Systems (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Wastewater Systems (Renewal) ICR Numbers: EPA ICR Number 1136.10, OMB Control Number 2060-0172. ICR Status... (NSPS) for Volatile Organic Compound (VOC) Emissions from Petroleum Refinery Wastewater Systems were...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-14
... No. 2020-0031 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance.... ICR numbers: EPA ICR No. 2185.04, OMB Control No. 2020-0031. ICR status: This ICR is currently...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-20
... Control No. 2060-0264 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In... Tribal Agencies. ICR numbers: EPA ICR No. 1643.07, OMB Control No. 2060-0264. ICR status: This ICR is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-24
....07, OMB Control No. 2060-0376 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY...). ICR numbers: EPA ICR No. 1663.07, OMB Control No.: 2060-0376. ICR status: This ICR is currently...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-29
...- Ignition Engines (Renewal). ICR Numbers: EPA ICR No. 1695.10, OMB Control No. 2060-0338. ICR Status: This... Engines and Equipment, OMB Control Number 2060-0603) were incorporated into ICR 1695.10. This action was... Requirements for Nonroad Spark-Ignition Engines (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-24
... for Assistance Programs (Renewal); EPA ICR No. 0938.18 AGENCY: Environmental Protection Agency. ACTION...: EPA ICR No. 0938.18, OMB Control Number 2030-0020. ICR Status: This ICR is scheduled to expire on...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-30
... Emission Recall Reports; EPA ICR No. 0282.15, OMB Control No. 2060-0048 AGENCY: Environmental Protection... Recall Reports (Renewal). ICR numbers: EPA ICR No. 0282.15, OMB Control No. 2060-0048. ICR status: This...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-01
... Production Residual Risk and Technology Review (RTR); EPA ICR No. 2400.01, OMB Control Number 2060--NEW...: EPA ICR No. 2400.01, OMB Control No. 2060--New. ICR Status: This ICR is for a new information...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-12
... Fine Particle Matter and Ozone (Renewal); EPA ICR No. 2152.05, OMB Control No. 2060-0570 AGENCY... Matter and Ozone (Renewal). ICR number: EPA ICR No. 2152.05, OMB Control No. 2060-0570. ICR Status: This...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-25
... Submitted to OMB for Review and Approval; Comment Request; EPA's Design for the Environment Formulator... Environment Formulator Product Recognition Program'' (EPA ICR No. 2302.02, OMB Control No. 2070-0178), to the..., visit http://www.epa.gov/dockets . Abstract: EPA's Design for the Environment (DfE) Formulator Product...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-27
... Facilities (Renewal), EPA ICR No. 2060.04, OMB Control No. 2040-0257 AGENCY: Environmental Protection Agency...: Cooling Water Intake Structure Phase II Existing Facilities (Renewal). ICR Numbers: EPA ICR No. 2060.04... (EPA ICR No. 2060.03) covers the last 2 years of the permit approval period (i.e., years 4 and 5 after...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-05
... identity or contact information unless you provide it in the body of your comment. If you send an e-mail... and other contact information in the body of your comment and with any disk or CD-ROM you submit. If..., OMB Control No. 2060-0528. ICR Status: This ICR is currently scheduled to expire on March 31, 2011. An...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-21
... (Renewal), EPA ICR Number 1781.05, OMB Control Number 2060- 0358 AGENCY: Environmental Protection Agency... ICR Number 1781.05, OMB Control Number 2060-0358. ICR Status: This ICR is scheduled to expire on July...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-28
..., Catalytic Cracking, Reforming and Sulfur Units (Renewal); EPA ICR Number 1844.04, OMB Control Number 2060... ICR Number 1844.04, OMB Control Number 2060-0554. ICR Status: This ICR is scheduled to expire on...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-12
..., Surface Impoundments and Containers (Renewal), EPA ICR Number 1593.08, OMB Control Number 2060-0318 AGENCY... ICR Number 1593.08, OMB Control Number 2060-0318. ICR Status: This ICR is scheduled to expire on...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-22
... New and In-Use Portable Gasoline Containers (Renewal), EPA ICR 2213.03, OMB Control No. 2060-0597...-Use Portable Gasoline Containers (Renewal). ICR Numbers: EPA ICR No. 2213.03, OMB Control No. 2060...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-08
... No. 2236.03, OMB Control No. 2060-0594 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Standard Implementation Rule. ICR numbers: EPA ICR No. 2236.03, OMB Control No. 2060-0594. ICR status: This...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-05
... Commercial and Industrial Sectors; EPA ICR No. 1772.05, OMB Control No. 2060-0347 AGENCY: Environmental... in the Commercial and Industrial Sectors. ICR Numbers: EPA ICR No. 1772.05, OMB Control No. 2060-0347...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-13
... Activities; Proposed Collection; Comment Request; Contractor Conflicts of Interest AGENCY: Environmental....regulations.gov . Title: Contractor Conflicts of Interest. ICR numbers: EPA ICR No. 1550.09, OMB Control No... control numbers in certain EPA regulations is consolidated in 40 CFR part 9. Abstract: EPA contractors...
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75 FR 39244 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-08
.... EPA ICR Number 2098.05; NESHAP for Primary Magnesium Refining; 40 CFR part 63, subparts A and TTTTT.... EPA ICR Number 1666.08; NESHAP for Commercial Ethylene Oxide Sterilization and Fumigation Operations...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-25
... Composites Production (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In...: NESHAP for Reinforced Plastic Composites Production (Renewal) ICR Numbers: EPA ICR Number 1976.05, OMB...: Owners or operators of reinforced plastic composites production facilities. Estimated Number of...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-13
... Request Submitted to OMB for Review and Approval; Comment Request; EPA's Design for the Environment (DfE... Environment (DfE) Logo Redesign Consultations'' (EPA ICR No. 2487.01, OMB Control No. 2070-NEW) to the Office... (EPA) will select a revised logo and messaging for its Design for the Environment (DfE) program. A key...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-02
... them and without change, unless the comment contains copyrighted material, Confidentiality of Business... Combustors (Renewal) . ICR Numbers: EPA ICR Number 1900.05, OMB Control Number 2060-0423. ICR Status: This...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-27
..., Quenching, and Battery Stacks (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...: NESHAP for Coke Oven Pushing Quenching and Battery Stacks (Renewal). ICR Numbers: EPA ICR Number 1995.05..., quenching, and battery stacks. Estimated Number of Respondents: 19. Frequency of Response: Initially...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-23
... Manufacturing and Phosphate Fertilizers Production (Renewal), EPA ICR Number 1790.05, OMB Control Number 2060... Number 1790.05, OMB Control Number 2060-0361. ICR Status: This ICR is scheduled to expire on June 30...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
... Facilities (Renewal), EPA ICR Number 1659.07, OMB Control Number 2060- 0325 AGENCY: Environmental Protection... Control Number 2060-0325. ICR Status: This ICR is scheduled to expire on August 31, 2010. Under OMB...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-01
... Surface Coating (Renewal), EPA ICR Number 2044.04, OMB Control Number 2060-0537 AGENCY: Environmental....04, OMB Control Number 2060-0537. ICR Status: This ICR is scheduled to expire on April 30, 2010...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-09
... Facilities (Renewal), EPA ICR Number 1135.10, OMB Control Number 2060- 0171 AGENCY: Environmental Protection... Control Number 2060-0171. ICR Status: This ICR is scheduled to expire on July 31, 2010. Under OMB...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-27
... Vegetable Oil Production (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY... for Solvent Extraction for Vegetable Oil Production (Renewal). ICR Numbers: EPA ICR Number 1947.05... disclose the information. Respondents/Affected Entities: Owners or operators of vegetable oil production...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-27
... Distribution (Non-Gasoline) Facilities (Renewal), EPA ICR Number 1963.04, OMB Control Number 2060-0539 AGENCY... Control Number 2060-0539. ICR Status: This ICR is scheduled to expire on July 30, 2010. Under OMB...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-28
... Activities; Proposed Collection; Comment Request; National Pollutant Discharge Elimination System (NPDES... viruses. For additional information about EPA's public docket, visit the EPA Docket Center homepage at... Pollutant Discharge Elimination System (NPDES) Program (Renewal). ICR Number: EPA ICR No. 0229.20, OMB...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-01
... Gasoline (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance...: Detergent Gasoline (Renewal). ICR numbers: EPA ICR No. 1655.07, OMB Control No. 2060-0275. ICR Status: This... regulations is consolidated in 40 CFR part 9. Abstract: Gasoline combustion results in the formation of engine...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-05
... Label Surface Coating Operations (Renewal), EPA ICR Number 0658.10, OMB Control Number 2060-0004 AGENCY... Number 2060-0004. ICR Status: This ICR is scheduled to expire on May 31, 2010. Under OMB regulations, the...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-21
... Coating and Printing (Renewal), EPA ICR Number 1157.09, OMB Control Number 2060-0073 AGENCY: Environmental....09, OMB Control Number 2060-0073. ICR Status: This ICR is scheduled to expire on May 31, 2010. Under...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-01
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Pulp and Paper Production... FURTHER INFORMATION CONTACT: Learia Williams, Monitoring, Assistance, and Media Programs Division, Office... Production (Renewal). ICR Numbers: EPA ICR Number 1657.07, OMB Control Number 2060-0387. ICR Status: This ICR...
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77 FR 37670 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-22
... Generators, Transporters, and Waste Management Facilities under the RCRA Hazardous Waste Manifest System... without change. EPA ICR Number 1695.12; Emissions Certification and Compliance Requirements for Marine and... change. Withdrawn and Continue EPA ICR Number 2127.02; Conditional Exclusions from Solid Waste and...
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76 FR 6780 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-08
... Action Plan/Activity Integration Plan (CAP/AIP) Reporting System; was approved on 01/06/2011; OMB Number... without change. EPA ICR Number 1445.09; Continuous Release Reporting Regulations (CRRR) under CERCLA; 40... change. EPA ICR Number 1445.10; Continuous Release Reporting Regulations (CRRR) under CERCLA; 40 CFR 302...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-25
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Flexible Polyurethane Foam... Constitution Avenue NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4... Flexible Polyurethane Foam Fabrication (Renewal). ICR Numbers: EPA ICR Number 2027.05, OMB Control Number...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-27
... Activities; Submission to OMB for Review and Approval; Comment Request; Exchange Network Grants Progress...: Exchange Network Grants Progress Reports (Renewal). ICR Numbers: EPA ICR No. 2207.04, OMB Control No. 2025... Network (NEIEN) Grant Program. The EPA Office of Environmental Information provides funding to EPA's...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-12
... Part 63, Subpart VVVV) (Renewal), EPA ICR Number 1966.04, OMB Control Number 2060-0546 AGENCY... 2060-0546. ICR Status: This ICR is schedule to expire on September 30, 2010. Under OMB regulations, the...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-22
...) Greenhouse Gas Inventory Pilot (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Management and Budget (OMB), Attention: Desk Officer for EPA, 725 17th Street NW., Washington, DC 20503. FOR... (Small Business) Greenhouse Gas Inventory Pilot (Renewal) ICR numbers: EPA ICR No. 2100.05, OMB Control...
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77 FR 56200 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-12
... on 08/31/2015; Approved with change. EPA ICR Number 2192.05; Unregulated Contaminant Monitoring in Public Water Systems (Final Rule); 40 CFR 141.35 and 141.40; was approved on 08/06/2012; OMB Number 2040-0270; expires on 08/31/2015; Approved with change. EPA ICR Number 1560.10; National Water Quality...
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76 FR 39870 - Agency Information Collection Activities; OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-07
... 06/30/2014; Approved without change. EPA ICR Number 1741.06; Correction of Misreported Chemical Substances on the Toxic Substances Control Act (TSCA) Chemical Substances Inventory; was approved on 06/01... 2070-0028; expires on 06/30/2014; Approved without change. EPA ICR Number 1198.09; Chemical-Specific...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-07
... Activities; Proposed Collection; Comment Request; Focus Groups as Used by EPA for Economics Projects (Renewal... used by EPA for Economics Projects (Renewal). ICR numbers: EPA ICR No. 2205.07, OMB Control No. 2090... interviews (hereafter jointly referred to as focus groups) related to economics projects. Over the next three...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-07
... Research Involving Human Subjects. ICR number: EPA ICR No. 2195.04. OMB control number: OMB Control No... for environmental research involving human subjects under FIFRA and/or FFDCA. Although EPA has only... issued a final rule to amend the Federal Policy for the Protection of Human Subjects (also known as the...
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78 FR 3893 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-17
.../31/2015; Approved with change. EPA ICR Number 1803.06; Drinking Water State Revolving Fund Program... INFORMATION: OMB Responses to Agency Clearance Requests OMB Approvals EPA ICR Number 1973.05; Cooling Water...; Establishing No-Discharge Zones Under Clean Water Act Section 312 (Renewal); 40 CFR parts 140 and 1700; was...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-28
... Other Solid Waste Incineration Units (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION...: Emission Guidelines for Existing Other Solid Waste Incineration Units (Renewal). ICR Numbers: EPA ICR... disclose the information. Respondents/Affected Entities: Owners or operators of other existing solid waste...
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76 FR 55664 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-08
...; Approved with change. EPA ICR Number 2277.03; NESHAP for Area Sources: Electric Arc Furnace Steelmaking... Miscellaneous Surface Coating at Area Sources; 40 CFR part 63 subparts A and HHHHHH; was approved on 08/04/2011...; Approved without change. EPA ICR Number 1550.09; Conflict of Interest Rule 1 (Renewal); 40 CFR 486; was...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-06
... Steel Manufacturing (Renewal). ICR Numbers: EPA ICR Number 2003.05, OMB Control Number 2060-0517. ICR...: The NESHAP for Integrated Iron and Steel Manufacturing are subject to the General Provisions of the... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Integrated Iron and Steel...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-27
... Number 1750.06, OMB Control Number 2060-0393 AGENCY: Environmental Protection Agency (EPA). ACTION... Number 2060-0393. ICR status: This ICR is currently scheduled to expire on December 31, 2011. An Agency...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-20
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Engine Test Cells/ Stands... Cells/Stands (Renewal) ICR Numbers: EPA ICR Number 2066.05, OMB Control Number 2060-0483. ICR Status... Hazardous Air Pollutants (NESHAP) for Engine Test Cells/Stands were proposed on May 14, 2002 (67 FR 34547...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-28
... Number 1907.05, OMB Control Number 2060-0437 AGENCY: Environmental Protection Agency (EPA). ACTION... No. 1907.05, OMB Control Number 2060-0437. ICR Status: This ICR is scheduled to expire on July 31...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-23
... Emissions From Basic Oxygen Furnaces (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...: NSPS for Primary and Secondary Emissions from Basic Oxygen Furnaces (Renewal). ICR Numbers: EPA ICR... Primary and Secondary Emissions from Basic Oxygen Furnaces (40 CFR part 60, subparts N and Na) were...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-08
... of Qualitative Feedback on Agency Service Delivery (New) AGENCY: Environmental Protection Agency (EPA... Qualitative Feedback on Agency Service Delivery (New). ICR numbers: EPA ICR Nos. 2434.01 and 2435.01, OMB... in 40 CFR part 9. Abstract: The information collection activity will garner qualitative customer and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-04
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Site Remediation, EPA ICR... electronic docket, go to http://www.regulations.gov . Title: NESHAP for Site Remediation. ICR Numbers: EPA.... Abstract: 40 CFR part 63, subpart GGGGG, applies to site remediation activities to cleanup materials...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-25
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Semiconductor...: NESHAP for Semiconductor Manufacturing (Renewal). ICR Numbers: EPA ICR Number 2042.05, OMB Control Number... the owners or operators of semiconductor manufacturing plants. Estimated Number of Respondents: 1...
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ARI Environmental, Inc. (ARI) was retained by Houston Refining LP (HRO) to conduct an emission test program at their refinery located in Houston, Texas. The testing was conducted on on the 736 Delayed Coking Unit (DCU) in response to EPA's ICR.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-24
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Site Remediation (Renewal...: NESHAP for Site Remediation (Renewal). ICR Numbers: EPA ICR Number 2062.05, OMB Control Number 2060-0534.... Respondents/Affected Entities: Owners or operator of site remediation facilities. Estimated Number of...
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75 FR 76004 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-07
... without change. EPA ICR Number 1975.08; NESHAP for Stationary Reciprocating Internal Combustion Engines... Motor Vehicles (Proposed Rule); in 40 CFR parts 85, 86 and 600; OMB filed comment on 11/12/2010. EPA ICR... Duty Engines and Vehicles Equipped with On-Board Diagnostics (PR for Alt Fuel Conversion of Heavy-duty...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-16
...; Performance Evaluation Studies on Wastewater Laboratories (Renewal) AGENCY: Environmental Protection Agency... Evaluation Studies on Wastewater Laboratories (Renewal) ICR numbers: EPA ICR No. 0234.10, OMB Control No...
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Recorded ICR Overview Presentations
This presentation provides a brief overview of the applicability of the EPA’s Plywood and Composite Wood Products Information Collection Request, or “ICR,” for facilities that produce kiln‐dried lumber.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-23
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-RCRA-2010-0512, FRL- 9230-5] Agency Information Collection...), EPA ICR Number 1442.21, OMB Control Number 2050-0085 AGENCY: Environmental Protection Agency. ACTION.... ADDRESSES: Submit your comments, referencing Docket ID No. EPA-HQ-RCRA- 2010-0512, to (1) EPA, either online...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-09
... Benzene Storage Vessels and Coke By-Product Recovery Plants (Renewal) AGENCY: Environmental Protection... Storage Vessels and Coke By-Product Recovery Plants (Renewal) ICR Numbers: EPA ICR Number 1080.13, OMB... operators of benzene storage vessels and coke by product recovery plants. Estimated Number of Respondents...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-08
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Vinyl Chloride (Renewal... . Title: NESHAP for Vinyl Chloride (Renewal). ICR Numbers: EPA ICR Number 0186.12, OMB Control Number 2060... disclose the information. Respondents/Affected Entities: Owners or operators of vinyl chloride production...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-15
... Applicators Using 1080 Collars for Livestock Protection; EPA ICR No. 1249.09, OMB Control No. 2070-0074 AGENCY... . Title: Requirements for Certified Applicators Using 1080 Collars for Livestock Protection. ICR Numbers.... Abstract: This ICR affects approximately 40 certified pesticide applicators who utilize 1080 toxic collars...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-20
... contact information unless you provide it in the body of your comment. If you send an email comment... information in the body of your comment and with any disk or CD-ROM you submit. If EPA cannot read your... Laboratories Owned by Eligible Academic Entities. ICR numbers: EPA ICR No. 2317.02, OMB Control No. 2050-0204...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-08
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Beryllium Rocket Motor... . Title: NESHAP for Beryllium Rocket Motor Fuel Firing (Renewal). ICR Numbers: EPA ICR Number 1125.06, OMB...: Owners or operators of beryllium rocket motor fuel firing facilities. Estimated Number of Respondents: 1...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-24
... Approval; Comment Request; NESHAP for the Manufacture of Amino/Phenolic Resins AGENCY: Environmental... . Title: NESHAP for the Manufacture of Amino/Phenolic Resins (Renewal). ICR Numbers: EPA ICR Number 1869.... Abstract: The National Emission Standards for Hazardous Air Pollutants (NESHAP) for the Manufacture of...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-29
... Approval; Comment Request; National Volatile Organic Compound Emission Standards for Automobile Refinish... Standards for Automobile Refinish Coatings (Renewal). ICR Numbers: EPA ICR Number 1765.06, OMB Control... consumer and commercial products and a schedule for their regulation (60 FR 15264). Automobile refinish...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-11
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Pesticide Active... . Title: NESHAP for Pesticide Active Ingredient Production (Renewal). ICR Numbers: EPA ICR Number 1807.05... Air Pollutants (NESHAP) for Pesticide Active Ingredient Production were proposed on November 10, 1997...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-05
... Approval; Comment Request; NESHAP for Plywood and Composite Products (Renewal) AGENCY: Environmental... . Title: NESHAP for Plywood and Composite Products (Renewal). ICR Numbers: EPA ICR Number 1984.04, OMB... National Emission Standards for Hazardous Air Pollutants (NESHAP) for Plywood and Composite Products were...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-05
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Printing and Publishing....regulations.gov . Title: NESHAP for Printing and Publishing Industry (Renewal). ICR Numbers: EPA ICR Number.... Abstract: The National Emission Standards of Hazardous Air Pollutants (NESHAP) for Printing and Publishing...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-21
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for the Wood Building Products...: NESHAP for the Wood Building Products Surface Coating Industry (Renewal). ICR Numbers: EPA ICR Number... transmit or otherwise disclose the information. Respondents/Affected Entities: Owners or operators of wood...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-13
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Mercury Cell Chlor- Alkali...: NESHAP for Mercury Cell Chlor-Alkali Plants (Renewal). ICR Numbers: EPA ICR Number 2046.07, OMB Control... disclose the information. Respondents/Affected Entities: Owners or operators of mercury cell chlor-alkali...
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EPA Science Matters Newsletter: Volume 3, Number 4
In this issue of EPA's Science Matters, learn more about how EPA researchers and their partners are working to protect children from environmental threats and promote environmental health wherever they live, learn, and play.
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78 FR 68053 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-13
... Effects Abroad of EPA Actions (Renewal); 40 CFR 6.301; was approved on 10/18/ 2013; OMB Number 2020-0033...- 0095; expires on 10/31/2016; Approved without change. Comment Filed EPA ICR Number 2300.12; Greenhouse...
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EPA Science Matters Newsletter: Volume 3, Number 1
This issue of EPA's Science Matters highlights stories that exemplify some of the important impacts of EPA researchers and their partners working to provide the science and technology needed to protect human health and the environment.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-09
.... Title: NESHAP for Engine Test Cells/Stands (40 CFR Part 63, Subpart PPPPP). ICR Numbers: EPA ICR Number.... Title: NESHAP for Steel Pickling, HCL Process Facilities and Hydrochloric Acid Regeneration Plants (40... Engine Test Cells/Stands (40 CFR Part 63, Subpart PPPPP); Learia Williams of the Office of Compliance...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-21
... Facilities Cooling Water Intake Structures: Instrument, Pre-test, and Implementation (New). ICR numbers: EPA... test for and ameliorate survey non-response bias. EPA will follow standard practice in stated...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-20
... Nonroad Spark-Ignited Engines, New Nonroad Compression-Ignited Engines, and New On-Road Heavy Duty Engines... Compression-ignited Engines, and New On-road Heavy Duty Engines (Renewal). ICR numbers: EPA ICR No. 1852.05... engines, new nonroad compression-ignited engines, and new on- road heavy duty engines. Estimated Number of...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-03
... Control No. 2060-0528. ICR Status: This ICR is scheduled to expire on March 31, 2011. Under OMB..., a collection of information, unless it displays a currently valid OMB control number. The OMB control numbers for EPA's regulations in title 40 of the CFR, after appearing in the Federal Register when...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-26
... purposes of collecting, validating, and verifying information, processing and maintaining information, and... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2012-0693; FRL-9528-5] Agency Information Collection... Processing (Renewal), EPA ICR Number 2050.05 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-12
... impacts of nongovernmental activities in Antarctica, including tourism, for which the United States is... Activities; Submission to OMB for Review and Approval; Comment Request; Environmental Impact Assessment of... . Title: Environmental Impact Assessment of Nongovernmental Activities in Antarctica. ICR numbers: EPA ICR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-14
... Activities; Submission to OMB for Review and Approval; Comment Request; Brownfields Program-- Accomplishment..., Office of Brownfields and Land Revitalization, (5105T), Environmental Protection Agency, 1200...: Brownfields Program--Accomplishment Reporting (Renewal). ICR numbers: EPA ICR No. 2104.04, OMB Control No...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-19
... Approval; Comment Request; NSPS for Commercial and Industrial Solid Waste Incineration Units (Renewal... . Title: NSPS for Commercial and Industrial Solid Waste Incineration Units (Renewal). ICR Numbers: EPA ICR.... Abstract: The New Source Performance Standards (NSPS) for Commercial and Industrial Solid Waste...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-25
...; Comment Request; GreenChill Advanced Refrigeration Partnership AGENCY: Environmental Protection Agency...Chill Advanced Refrigeration Partnership. ICR numbers: EPA ICR No. 2349.01, OMB Control No. 2060-New... is consolidated in 40 CFR part 9. Abstract: The GreenChill Advanced Refrigeration Partnership...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-07
... ICR under docket ID number EPA-HQ-OECA-2012-0505, which is available for public viewing online at http://www.regulations.gov , or in person viewing at the Enforcement and Compliance Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334, 1301 Constitution Avenue NW., Washington, DC. The EPA Docket Center...
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Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis.
Wei, Wenhui; Srinivas, Swaminath; Lin, Jingxia; Tang, Zichen; Wang, Shihua; Ullah, Saif; Kota, Vishnu Goutham; Feng, Youjun
2018-05-14
Polymyxin is the last line of defense against severe infections caused by carbapenem-resistant gram-negative pathogens. The emergence of transferable MCR-1/2 polymyxin resistance greatly challenges the renewed interest in colistin (polymyxin E) for clinical treatments. Recent studies have suggested that Moraxella species are a putative reservoir for MCR-1/2 genetic determinants. Here, we report the functional definition of ICR-Mo from M. osloensis, a chromosomally encoded determinant of colistin resistance, in close relation to current MCR-1/2 family. ICR-Mo transmembrane protein was prepared and purified to homogeneity. Taken along with an in vitro enzymatic detection, MALDI-TOF mass spectrometry of bacterial lipid A pools determined that the ICR-Mo enzyme might exploit a possible "ping-pong" mechanism to accept the phosphoethanolamine (PEA) moiety from its donor phosphatidylethanolamine (PE) and then transfer it to the 1(or 4')-phosphate position of lipid A via an ICR-Mo-bound PEA adduct. Structural decoration of LPS-lipid A by ICR-Mo renders the recipient strain of E. coli resistant to polymyxin. Domain swapping assays indicate that the two domains of ICR-Mo cannot be functionally-exchanged with its counterparts in MCR-1/2 and EptA, validating its phylogenetic position in a distinct set of MCR-like genes. Structure-guided functional mapping of ICR-Mo reveals a PE lipid substrate recognizing cavity having a role in enzymatic catalysis and the resultant conference of antibiotic resistance. Expression of icr-Mo in E. coli significantly prevents the formation of reactive oxygen species (ROS) induced by colistin. Taken together, our results define a member of a group of intrinsic colistin resistance genes phylogenetically close to the MCR-1/2 family, highlighting the evolution of transferable colistin resistance.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-06
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2010-0291; FRL- 9903-87-OEI] Agency Information Collection Activities: Submission to OMB for Review and Approval; State Review Framework; EPA ICR Number 2185.05 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-21
...; Comment Request; Engine Emission Defect Information Reports and Voluntary Emission Recall Reports (Renewal... Information Reports and Voluntary Emission Recall Reports (Renewal). ICR numbers: EPA ICR No. 0282.15, OMB... is required to recall the engines. Engine manufacturers are required to submit Defect Information...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-13
...; Comment Request; Recognition Application for Sustainable Water Leadership Program (Renewal) AGENCY... Sustainable Water Leadership Program (Renewal). ICR numbers: EPA ICR No. 1287.10, OMB Control No. 2040-0101... Sustainable Water Leadership Program, formerly the National Clean Water Act Recognition Awards Program and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-08
... number EPA-HQ- OECA-2012-0657, to: (1) EPA online, using www.regulations.gov (our preferred method), or... estimates that are attributed to the correction of mathematical discrepancies identified in the previous ICR...
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Psychometric properties of the Italian version of the Cognitive Reserve Scale (I-CRS).
Altieri, Manuela; Siciliano, Mattia; Pappacena, Simona; Roldán-Tapia, María Dolores; Trojano, Luigi; Santangelo, Gabriella
2018-05-04
The original definition of cognitive reserve (CR) refers to the individual differences in cognitive performance after a brain damage or pathology. Several proxies were proposed to evaluate CR (education, occupational attainment, premorbid IQ, leisure activities). Recently, some scales were developed to measure CR taking into account several cognitively stimulating activities. The aim of this study is to adapt the Cognitive Reserve Scale (I-CRS) for the Italian population and to explore its psychometric properties. I-CRS was administered to 547 healthy participants, ranging from 18 to 89 years old, along with neuropsychological and behavioral scales to evaluate cognitive functioning, depressive symptoms, and apathy. Cronbach's α, corrected item-total correlations, and the inter-item correlation matrix were calculated to evaluate the psychometric properties of the scale. Linear regression analysis was performed to build a correction grid of the I-CRS according to demographic variables. Correlational analyses were performed to explore the relationships between I-CRS and neuropsychological and behavioral scales. We found that age, sex, and education influenced the I-CRS score. Young adults and adults obtained higher I-CRS scores than elderly adults; women and participants with high educational attainment scored higher on I-CRS than men and participants with low education. I-CRS score correlated poorly with cognitive and depression scale scores, but moderately with apathy scale scores. I-CRS showed good psychometric properties and seemed to be a useful tool to assess CR in every adult life stage. Moreover, our findings suggest that apathy rather than depressive symptoms may interfere with the building of CR across the lifespan.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-22
...; Information Requirements for Importation of Nonconforming Vehicles; EPA ICR No. 0010.12, OMB Control No. 2060... Certification Program, EPA ICR No. 116.09, OMB Control No. 2060-0060; and Motor Vehicle and Engine Compliance Program Fees, EPA ICR 2080.04, OMB Control No. 2060-0545 AGENCY: Environmental Protection Agency (EPA...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-26
... Activities; Submission to OMB for Review and Approval; Comment Request; Recordkeeping Requirements for... Insecticide, Fungicide, and Rodenticide Act (FIFRA); EPA ICR No. 0143.11, OMB Control No. 2070-0028 AGENCY... Devices Under Section 8 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). ICR numbers...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
... Quality Standard Implementation Rule (Renewal), EPA ICR No. 2236.03, OMB Control No. 2060-0594 AGENCY...: EPA ICR No. 2236.03, OMB Control No. 2060-0594. ICR status: This ICR is scheduled to expire on July 31...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-07
... Activities; Submission to OMB for Review and Approval; Comment Request; Water Quality Standards Regulations....regulations.gov . Title: Water Quality Standards Regulation (Renewal). ICR numbers: EPA ICR No. 0988.11, OMB...: Water quality standards are provisions of State, Tribal, and Federal law that consist of designated uses...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-08
... Activities; Submission to OMB for Review and Approval; Comment Request; NSPS for New Residential Wood Heaters...://www.regulations.gov . Title: NSPS for New Residential Wood Heaters (Renewal). ICR Numbers: EPA ICR.... Abstract: The New Source Performance Standard for New Residential Wood Heaters was proposed on February 18...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-08
... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Epoxy Resin and Non- Nylon....gov . Title: NESHAP for Epoxy Resin and Non-Nylon Polyamide Production (Renewal). ICR Numbers: EPA ICR.... Abstract: The National Emission Standards for Hazardous Air Pollutants (NESHAP) for Epoxy Resin and Non...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-02
... Activities; Submission to OMB for Review and Approval; Comment Request; Fuels and Fuel Additives: Gasoline...: Regulation of Fuels and Fuel Additives: Gasoline Volatility (Renewal). ICR numbers: EPA ICR No. 1367.09, OMB...: Gasoline volatility, as measured by Reid Vapor Pressure (RVP) in pounds per square inch (psi), is...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-22
... Activities; Submission to OMB for Review and Approval; Comment Request; The Consolidated Air Rule (CAR) for... (CAR) for the Synthetic Organic Chemical Manufacturing Industry (SOCMI) (Renewal). ICR Numbers: EPA ICR... with the above standards under the Consolidated Air Rule (CAR) at 40 CFR part 65, as promulgated on...
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76 FR 66061 - Agency Information Collection Activities; Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-25
... and Reporting Requirements for Allegations of Significant Adverse Reactions to Human Health or the... Adverse Reactions to Human Health or the Environment (TSCA Section 8(c))''. ICR numbers: EPA ICR No. 1031... of significant adverse reactions to health or the environment alleged to have been caused by such...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-29
... purposes of collecting, validating, and verifying information, processing and maintaining information, and... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2012-0496; FRL-9527-1] Agency Information Collection... Processing and Asphalt Roofing Manufacturing (Renewal), EPA ICR Number 2352.03 AGENCY: Environmental...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-30
... Nongovernmental Activities in Antarctica; EPA ICR No. 1808.06, OMB Control No. 2020- 0007 AGENCY: Environmental..., which means EPA will not know your identity or contact information unless you provide it in the body of... ``search,'' then key in the docket ID number identified in this document. What information is EPA...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-05
.... Abstract: Section 404(g) of the Clean Water Act authorizes States and Tribes to assume the section 404... Activities; Submission to OMB for Review and Approval; Comment Request; Clean Water Act Section 404 State....regulations.gov . Title: Clean Water Act Section 404 State-Assumed Programs (Renewal). ICR numbers: EPA ICR No...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-27
... Activities; Proposed Collection; Comment Request; Valuing Improved Water Quality in the Chesapeake Bay Using...: Willingness to Pay for Improved Water Quality in the Chesapeake Bay. ICR numbers: EPA ICR No. 2456.01, OMB... Economics (NCEE) is undertaking a benefits analysis of improvements in Bay water quality under the TMDLs, as...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-26
... Asbestos Abatement Worker Protection; EPA ICR No. 1246.11, OMB No. 2070-0072 AGENCY: Environmental... for Asbestos Abatement Worker Protection; EPA ICR No. 1246.11, OMB No. 2070-0072. The ICR, which is... . Title: Reporting and Recordkeeping for Asbestos Abatement Worker Protection. ICR Status: This is a...
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78 FR 73521 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-06
... Number 1765.07; National Volatile Organic Compound Emission Standards for Automobile Refinish Coatings.../2016; Approved without change. EPA ICR Number 2345.03; Control of Emissions from New Marine Compression...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-02
... Participation Survey; EPA ICR No. 2375.01 OMB Control No. 2060-New AGENCY: Environmental Protection Agency (EPA... No. 2060-New. ICR status: This ICR is for a new information collection activity. An Agency may not...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-09
... containers, and track the serial numbers to their certificates of conformity. Any information submitted for... Gasoline Containers (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. [[Page 41059...), ``Control of Evaporative Emissions from Portable Gasoline Containers (Renewal) (EPA ICR No. 2213.04, OMB...
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Azzi, Salah; Blaise, Annick; Steunou, Virginie; Harbison, Madeleine D; Salem, Jennifer; Brioude, Frédéric; Rossignol, Sylvie; Habib, Walid Abi; Thibaud, Nathalie; Neves, Cristina Das; Jule, Marilyne Le; Brachet, Cécile; Heinrichs, Claudine; Bouc, Yves Le; Netchine, Irène
2014-10-01
Russell-Silver Syndrome (RSS) is a prenatal and postnatal growth retardation syndrome caused mainly by 11p15 ICR1 hypomethylation. Clinical presentation is heterogeneous in RSS patients with 11p15 ICR1 hypomethylation. We previously identified a subset of RSS patients with 11p15 ICR1 and multilocus hypomethylation. Here, we examine the relationships between IGF2 expression, 11p15 ICR1 methylation, and multilocus imprinting defects in various cell types from 39 RSS patients with 11p15 ICR1 hypomethylation in leukocyte DNA. 11p15 ICR1 hypomethylation was more pronounced in leukocytes than in buccal mucosa cells. Skin fibroblast IGF2 expression was correlated with the degree of ICR1 hypomethylation. Different tissue-specific multilocus methylation defects coexisted in 38% of cases, with some loci hypomethylated and others hypermethylated within the same cell type in some cases. Our new results suggest that tissue-specific epigenotypes may lead to clinical heterogeneity in RSS. © 2014 WILEY PERIODICALS, INC.
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78 FR 41794 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-11
... INFORMATION: OMB Responses To Agency Clearance Requests OMB Approvals EPA ICR Number 1981.05; Distribution of... Number 1160.12; NSPS/NESHAP for Wool Fiberglass Insulation Manufacturing Plants; 40 CFR part 60 subparts...
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Shaw, Jared B; Robinson, Errol W; Paša-Tolić, Ljiljana
2016-03-15
We revisited the implementation of 193 nm ultraviolet photodissociation (UVPD) within the ion cyclotron resonance (ICR) cell of a Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer. UVPD performance characteristics were examined in the context of recent developments in the understanding of UVPD and in-cell tandem mass spectrometry. Efficient UVPD and photo-ECD of a model peptide and proteins within the ICR cell of a FT-ICR mass spectrometer are accomplished through appropriate modulation of laser pulse timing, relative to ion magnetron motion and the potential applied to an ion optical element upon which photons impinge. It is shown that UVPD yields efficient and extensive fragmentation, resulting in excellent sequence coverage for model peptide and protein cations.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Shaw, Jared B.; Robinson, Errol W.; Pasa-Tolic, Ljiljana
2016-02-16
We revisited the implementation of UVPD within the ICR cell of a FT-ICR mass spectrometer. UVPD performance characteristics were examined in the context of recent developments in the understanding of UVPD and in-cell tandem mass spectrometry. Efficient UVPD and photo-ECD of a model peptide and small protein within the ICR cell of a FT-ICR mass spectrometer are accomplished through appropriate modulation of laser pulse timing relative to ion magnetron motion and the potential applied to an ion optical element that photons impinge on. It is shown that UVPD yields efficient and extensive fragmentation resulting in excellent sequence coverage for modelmore » peptide and protein cations.« less
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-27
...The Environmental Protection Agency is planning to submit an information collection request (ICR), ``Alternative Affirmative Defense Requirements for Ultra-low Sulfur Diesel'' (EPA ICR No.2364.04, OMB Control No. 2060-0639 to the Office of Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act (44 U.S.C. 3501 et seq.). Before doing so, EPA is soliciting public comments on specific aspects of the proposed information collection as described below. This is a proposed extension of the ICR, which is currently approved through March 31, 2014. An Agency may not conduct or sponsor and a person is not required to respond to a collection of information unless it displays a currently valid OMB control number.
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Terra, Luciana A; Filgueiras, Paulo R; Tose, Lílian V; Romão, Wanderson; de Souza, Douglas D; de Castro, Eustáquio V R; de Oliveira, Mirela S L; Dias, Júlio C M; Poppi, Ronei J
2014-10-07
Negative-ion mode electrospray ionization, ESI(-), with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) was coupled to a Partial Least Squares (PLS) regression and variable selection methods to estimate the total acid number (TAN) of Brazilian crude oil samples. Generally, ESI(-)-FT-ICR mass spectra present a power of resolution of ca. 500,000 and a mass accuracy less than 1 ppm, producing a data matrix containing over 5700 variables per sample. These variables correspond to heteroatom-containing species detected as deprotonated molecules, [M - H](-) ions, which are identified primarily as naphthenic acids, phenols and carbazole analog species. The TAN values for all samples ranged from 0.06 to 3.61 mg of KOH g(-1). To facilitate the spectral interpretation, three methods of variable selection were studied: variable importance in the projection (VIP), interval partial least squares (iPLS) and elimination of uninformative variables (UVE). The UVE method seems to be more appropriate for selecting important variables, reducing the dimension of the variables to 183 and producing a root mean square error of prediction of 0.32 mg of KOH g(-1). By reducing the size of the data, it was possible to relate the selected variables with their corresponding molecular formulas, thus identifying the main chemical species responsible for the TAN values.
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Toxicological effects of benzo[a]pyrene on DNA methylation of whole genome in ICR mice.
Zhao, L; Zhang, S; An, X; Tan, W; Pang, D; Ouyang, H
2015-10-30
It has been well known that alterations in DNA methylation - an important regulator of gene transcription - lead to cancer. Therefore a change in the level of DNA methylation of whole genome has been considered as a biomarker of carcinogenesis. Previously, a large number of experimental results in genetic toxicology have showed that benzo[a]pyrene could cause DNA mutation and fragmentation. However, there was little to no studies on alterations in DNA methylation of genome directly result from exposure to benzo[a]pyrene. In this paper, possible mechanisms of alterations in whole genomic DNA methylation by benzo[a]pyrene were investigated using ICR mice after benzo[a]pyrene exposure. The blood, liver, pancreas, skin, lung and bladder of ICR mice were removed and checked after a fixed time interval (6 hours) of benzo[a]pyrene exposure, and whole genomic DNA methylation level was determined by high performance liquid chromatography (HPLC). The results exhibited tissue specificity, that is, the level of whole genomic DNA methylation decreases significantly in blood and liver, rather than pancreas, lung, skin and bladder of ICR mice. This study investigated the direct relationship between aberrant DNA methylation level and benzo[a]pyrene exposure, which might be helpful to clarify the toxicological mechanism of benzo[a]pyrene in epigenetic perspectives.
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Cho, Yunju; Ahmed, Arif; Islam, Annana; Kim, Sunghwan
2015-01-01
Because of the increasing importance of heavy and unconventional crude oil as an energy source, there is a growing need for petroleomics: the pursuit of more complete and detailed knowledge of the chemical compositions of crude oil. Crude oil has an extremely complex nature; hence, techniques with ultra-high resolving capabilities, such as Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), are necessary. FT-ICR MS has been successfully applied to the study of heavy and unconventional crude oils such as bitumen and shale oil. However, the analysis of crude oil with FT-ICR MS is not trivial, and it has pushed analysis to the limits of instrumental and methodological capabilities. For example, high-resolution mass spectra of crude oils may contain over 100,000 peaks that require interpretation. To visualize large data sets more effectively, data processing methods such as Kendrick mass defect analysis and statistical analyses have been developed. The successful application of FT-ICR MS to the study of crude oil has been critically dependent on key developments in FT-ICR MS instrumentation and data processing methods. This review offers an introduction to the basic principles, FT-ICR MS instrumentation development, ionization techniques, and data interpretation methods for petroleomics and is intended for readers having no prior experience in this field of study. © 2014 Wiley Periodicals, Inc.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-12
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2013-0413; FRL--9832-8] Proposed Information Collection Request; Comment Request; Performance Evaluation Studies on Wastewater Laboratories (Renewal); EPA... request (ICR), ``Performance Evaluation Studies on Wastewater Laboratories'' (EPA ICR No. 0234.11, OMB...
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76 FR 12728 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-08
... without change. EPA ICR Number 2395.01; Aerospace Manufacturing And Rework Industry Information Collection... Additives: 2011 Renewable Fuel Standards--Petition for International Aggregate Compliance Approach; 40 CFR...
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From Supercomputer Modeling to Highest Mass Resolution in FT-ICR.
N Nikolaev, Evgene; N Vladimirov, Gleb; Jertz, Roland; Baykut, Gökhan
2013-01-01
Understanding of behavior of ion ensembles inside FT-ICR cell based on the computer simulation of ion motion gives rise to the new ideas of cell designs. The recently introduced novel FT-ICR cell based on a Penning ion trap with specially shaped excitation and detection electrodes prevents distortion of ion cyclotron motion phases (normally caused by non-ideal electric trapping fields) by averaging the trapping DC electric field during the ion motion in the ICR cell. Detection times of 5 min resulting in resolving power close to 40,000,000 have been reached for reserpine at m/z 609 at a magnetic field of only 7 Tesla. Fine structures of resolved 13Cn isotopic cluster groups could be measured for molecular masses up to 5.7 kDa (insulin) with resolving power of 4,000,000 at 7 Tesla. Based on resolved fine structure patterns atomic compositions can be directly determined using a new developed algorithm for fine structure processing. Mass spectra of proteins and multimers of proteins reaching masses up to 186 kDa (enolase tetramer) could be measured with isotopic resolution. For instance, at 7 Tesla resolving power of 800,000 was achieved for enolase dimer (96 kDa) and 500,000 for molecular masses above 100 kDa. Experimental data indicate that there is practically no limit for the resolving power of this ICR cell except by collisional damping in the ultrahigh vacuum chamber.
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EPA Science Matters Newsletter: Volume 3, Number 3
The Agency's Safe and Sustainable Water Research program—the focus of this special issue of EPA's Science Matters—is designed to provide the innovative science and engineering solutions needed for protecting the nation's water resources today.
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EPA Science Matters Newsletter: Volume 2, Number 6
EPA research has embraced sustainability as a necessary goal for the future of the planet, our economy, and our society. To achieve it will require asking different questions, thinking about challenges differently, and seeking innovative solutions.
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75 FR 2538 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-15
... Municipal Waste Combustion Units Constructed on or before August 30, 1999; 40 CFR part 60, subpart A and 40...; expires on 12/31/2012; Approved with change. EPA ICR Number 2076.03; EPA's National Partnership for.... 2010-733 Filed 1-14-10; 8:45 am] BILLING CODE 6560-50-P ...
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Yamaguchi, Takeshi; Nagasawa, Mao; Ikeda, Hiromi; Kodaira, Momoko; Minaminaka, Kimie; Chowdhury, Vishwajit S; Yasuo, Shinobu; Furuse, Mitsuhiro
2017-06-15
Attention-deficit hyperactivity disorder (ADHD) is defined as attention deficiency, restlessness and distraction. The main characteristics of ADHD are hyperactivity, impulsiveness and carelessness. There is a possibility that these abnormal behaviors, in particular hyperactivity, are derived from abnormal dopamine (DA) neurotransmission. To elucidate the mechanism of high locomotor activity, the relationship between innate activity levels and brain monoamines and amino acids was investigated in this study. Differences in locomotor activity between ICR, C57BL/6J and CBA/N mice were determined using the open field test. Among the three strains, ICR mice showed the greatest amount of locomotor activity. The level of striatal and cerebellar DA was lower in ICR mice than in C57BL/6J mice, while the level of L-tyrosine (L-Tyr), a DA precursor, was higher in ICR mice. These results suggest that the metabolic conversion of L-Tyr to DA is lower in ICR mice than it is in C57BL/6J mice. Next, the effects of intraperitoneal injection of (6R)-5, 6, 7, 8-tetrahydro-l-biopterin dihydrochloride (BH 4 ) (a co-enzyme for tyrosine hydroxylase) and L-3,4-dihydroxyphenylalanine (L-DOPA) on DA metabolism and behavior in ICR mice were investigated. The DA level in the brain was increased by BH 4 administration, but the increased DA did not influence behavior. However, L-DOPA administration drastically lowered locomotor activity and increased DA concentration in several parts of the brain. The reduced locomotor activity may have been a consequence of the overproduction of DA. In conclusion, the high level of locomotor activity in ICR mice may be explained by a strain-specific DA metabolism. Copyright © 2017 Elsevier B.V. All rights reserved.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-08
... Nonconforming Vehicles (Renewal)'', EPA ICR No. 0010.13, OMB Control No. 2060-0095; ``Control of Evaporative Emissions from New and In-Use Portable Gasoline Containers (Renewal)'', ICR 2213.04, OMB 2060-0597; and ``Motor Vehicle and Engine Compliance Program Fees (Renewal)'', EPA ICR 2080.05, OMB Control No. 2060-0545...
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EPA Science Matters Newsletter: Volume 2, Number 4
While continuing to advance the kinds of cutting edge research efforts that are the hallmark of EPA, we also are taking ambitious steps to ensure that we are as effective as we can be for the American people.
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EPA Science Matters Newsletter: Volume 2, Number 4
2017-02-14
While continuing to advance the kinds of cutting edge research efforts that are the hallmark of EPA, we also are taking ambitious steps to ensure that we are as effective as we can be for the American people.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-23
... Request Submitted to OMB for Review and Approval; Comment Request; Information Requirements for Boilers...), ``Information Requirements for Boilers and Industrial Furnaces (Renewal)'' (EPA ICR No. ICR No. 1361.16, OMB... http://www.epa.gov/dockets . Abstract: EPA regulates the burning of hazardous waste in boilers...
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78 FR 56693 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-13
... filed comment on 08/ 13/2013. Withdrawn and Continue EPA ICR Number 1696.07; Fuels and Fuel Additives: Health-Effects Research Requirements for Manufacturers; Withdrawn from OMB and Continue existing...
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NASA Astrophysics Data System (ADS)
McKenna, Amy
2013-03-01
events in the FT-ICR experiment. For example, the high density of peaks at each nominal mass unit provides unprecedented insight into how excitation conditions affect ion motion during detection. Aggregated oil (i.e., tar balls, tar mats) that reached the surface exhibits a more than two-fold increase in the total number of detected species, with an increased number of oxygenated species. Principal component analysis (PCA) applied to two possible source oils (contained within the same ship) and weathered samples provide the first application of FT-ICR MS for source identification. Molecular formulae from parent and weathered oil indicate that the lightest petroleum fractions (saturated hydrocarbons) are the most readily oxidized components, and can serve as a template to determine chemical transformations that occur throughout the water column. The ability to differentiate and catalogue compositional changes that occur to oil after its release into the environment relies heavily on gains achieved in nearly all steps in the FT-ICR mass spectral experiment required to accommodate larger ion populations inherent to heavily weathered crude oil. Here, we present the requirement for FT-ICR MS for comprehensive oil spill characterization, and highlight advances made to FT-ICR MS experimental conditions developed from petroleum characterization. Work supported by DMR-06-54118, NSF CHE-10-49753 (RAPID), BP/The Gulf of Mexico Research Initiative, and the State of Florida
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-28
... Maximum Achievable Control Technology Standards for Carbon Black, Ethylene, Cyanide and Spandex (Renewal... Control Technology Standards for Carbon Black, Ethylene, Cyanide and Spandex (Renewal). ICR Numbers: EPA... control technology standards for carbon black, ethylene, cyanide and spandex facilities. Estimated Number...
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Jiang, Ting; Chen, Yu; Mao, Lu; Marshall, Alan G; Xu, Wei
2016-01-14
It is known that the ion collision cross section (CCS) may be calculated from the linewidth of a Fourier transform ion cyclotron resonance (FT-ICR) mass spectral peak at elevated pressure (e.g., ∼10(-6) Torr). However, the high mass resolution of FT-ICR is sacrificed in those experiments due to high buffer gas pressure. In this study, we describe a linewidth correction method to eliminate the windowing-induced peak broadening effect. Together with the energetic ion-neutral collision model previously developed by our group, this method enables the extraction of CCSs of biomolecules from high-resolution FT-ICR mass spectral linewidths, obtained at a typical operating buffer gas pressure of modern FT-ICR instruments (∼10(-10) Torr). CCS values of peptides including MRFA, angiotensin I, and bradykinin measured by the proposed method agree well with ion mobility measurements, and the unfolding of protein ions (ubiquitin) at higher charge states is also observed.
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2D FT-ICR MS of Calmodulin: A Top-Down and Bottom-Up Approach.
Floris, Federico; van Agthoven, Maria; Chiron, Lionel; Soulby, Andrew J; Wootton, Christopher A; Lam, Yuko P Y; Barrow, Mark P; Delsuc, Marc-André; O'Connor, Peter B
2016-09-01
Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry (2D FT-ICR MS) allows data-independent fragmentation of all ions in a sample and correlation of fragment ions to their precursors through the modulation of precursor ion cyclotron radii prior to fragmentation. Previous results show that implementation of 2D FT-ICR MS with infrared multi-photon dissociation (IRMPD) and electron capture dissociation (ECD) has turned this method into a useful analytical tool. In this work, IRMPD tandem mass spectrometry of calmodulin (CaM) has been performed both in one-dimensional and two-dimensional FT-ICR MS using a top-down and bottom-up approach. 2D IRMPD FT-ICR MS is used to achieve extensive inter-residue bond cleavage and assignment for CaM, using its unique features for fragment identification in a less time- and sample-consuming experiment than doing the same thing using sequential MS/MS experiments. Graphical Abstract ᅟ.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-06
... Inventory; EPA ICR No. 1741.06, OMB Control No. 2070-0145 AGENCY: Environmental Protection Agency (EPA... Control Act (TSCA) Inventory and regulated under TSCA section 8, who had reported to the initial effort to...: ``Correction of Misreported Chemical Substances on the TSCA Inventory'' and identified by EPA ICR No. 1741.06...
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76 FR 33272 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-08
...; Approved without change. EPA ICR Number 1365.09; Asbestos-Containing Materials in Schools and Asbestos... Recordkeeping for Asbestos Abatement Worker Protection; 40 CFR part 763, subpart G; was approved on 05/31/2011...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-03
... Request; Comment Request; Reformulated Gasoline Commingling Provisions AGENCY: Environmental Protection... information collection request (ICR), ``Reformulated Gasoline Commingling Provisions'' (EPA ICR No.2228.04.... Abstract: EPA would like to continue collecting notifications from gasoline retailers and wholesale...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-15
... ICR No. 1665.10, OMB Control No. 2020-0003 AGENCY: Environmental Protection Agency. ACTION: Notice...: EPA ICR No. 1665.10, OMB Control No. 2020-0003. ICR Status: This ICR is scheduled to expire on...
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Development and Evaluation of EPA Method 1615 for Detection of Enterovirus and Norovirus in Water
Brinkman, Nichole E.; Griffin, Shannon M.; McMinn, Brian R.; Rhodes, Eric R.; Varughese, Eunice A.; Grimm, Ann C.; Parshionikar, Sandhya U.; Wymer, Larry; Fout, G. Shay
2013-01-01
The U.S. EPA developed a sample concentration and preparation assay in conjunction with the total culturable virus assay for concentrating and measuring culturable viruses in source and drinking waters as part of the Information Collection Rule (ICR) promulgated in 1996. In an effort to improve upon this method, the U.S. EPA recently developed Method 1615: Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. Method 1615 uses a culturable virus assay with reduced equipment and labor costs compared to the costs associated with the ICR virus method and introduces a new molecular assay for the detection of enteroviruses and noroviruses by reverse transcription-quantitative PCR. In this study, we describe the optimization of several new components of the molecular assay and examine virus recovery from ground, reagent-grade, and surface water samples seeded with poliovirus type 3 and murine norovirus. For the culturable virus and molecular assays, mean poliovirus recovery using the complete method was 58% and 20% in groundwater samples, 122% and 39% using low-titer spikes in reagent-grade water, 42% and 48% using high-titer spikes in reagent-grade water, and 11% and 10% in surface water with high turbidity, respectively. Murine norovirus recovery by the molecular assay was 30% in groundwater samples, less than 8% in both low- and high-titer spikes in reagent-grade water, and 6% in surface water with high turbidity. This study demonstrates the effectiveness of Method 1615 for use with groundwater samples and highlights the need for further research into its effectiveness with surface water. PMID:23087037
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78 FR 26772 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-08
...-0001; expires on 04/30/2016; Approved without change. EPA ICR Number 2046.07; NESHAP for Mercury Cell... Nonferrous Metals--Zinc, Cadmium, and Beryllium (Renewal); 40 CFR part 63 subparts A, DDDDDD, EEEEEE, FFFFFF...
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77 FR 46752 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-06
... Pollution Contingency Plan (NCP)(Renewal); Withdrawn from OMB on 07/19/ 2012 while existing approved... change. EPA ICR Number 2310.02; RCRA Definition of Solid Waste (Renewal); 40 CFR parts 260 and 261; was...
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NASA Astrophysics Data System (ADS)
Weisbrod, Chad R.; Kaiser, Nathan K.; Syka, John E. P.; Early, Lee; Mullen, Christopher; Dunyach, Jean-Jacques; English, A. Michelle; Anderson, Lissa C.; Blakney, Greg T.; Shabanowitz, Jeffrey; Hendrickson, Christopher L.; Marshall, Alan G.; Hunt, Donald F.
2017-09-01
High resolution mass spectrometry is a key technology for in-depth protein characterization. High-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) enables high-level interrogation of intact proteins in the most detail to date. However, an appropriate complement of fragmentation technologies must be paired with FTMS to provide comprehensive sequence coverage, as well as characterization of sequence variants, and post-translational modifications. Here we describe the integration of front-end electron transfer dissociation (FETD) with a custom-built 21 tesla FT-ICR mass spectrometer, which yields unprecedented sequence coverage for proteins ranging from 2.8 to 29 kDa, without the need for extensive spectral averaging (e.g., 60% sequence coverage for apo-myoglobin with four averaged acquisitions). The system is equipped with a multipole storage device separate from the ETD reaction device, which allows accumulation of multiple ETD fragment ion fills. Consequently, an optimally large product ion population is accumulated prior to transfer to the ICR cell for mass analysis, which improves mass spectral signal-to-noise ratio, dynamic range, and scan rate. We find a linear relationship between protein molecular weight and minimum number of ETD reaction fills to achieve optimum sequence coverage, thereby enabling more efficient use of instrument data acquisition time. Finally, real-time scaling of the number of ETD reactions fills during method-based acquisition is shown, and the implications for LC-MS/MS top-down analysis are discussed. [Figure not available: see fulltext.
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Differential effects of MK-801 on cerebrocortical neuronal injury in C57BL/6J, NSA, and ICR mice.
Brosnan-Watters, G; Ogimi, T; Ford, D; Tatekawa, L; Gilliam, D; Bilsky, E J; Nash, D
2000-08-01
1. Antagonists of the N-methyl-D-aspartate (NMDA) glutamate (Glu) receptor, including [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate], dizocilpine maleate (MK-801), injure pyramidal neurons in the posterior cingulate/retrosplenial (PC/RS) cortex when administered systemically to adult rats and mice. 2. These results have, to our knowledge, only been reported previously in Harlan Sprague Dawley albino rats and International Cancer Research (ICR) mice, an outbred albino strain. 3. Male Non-Swiss Albino (NSA) mice, an albino outbred strain, and male C57BL/6J (B6) mice, a pigmented inbred strain, were injected systemically with 1 mg/kg of MK-801 in the first experiment. This dose of MK-801 reliably produces cytoplasmic vacuoles in neurons in layers III and IV of the PC/RS cortex in 100% of ICR mice treated 4. There was a significant difference in the number of vacuolated neurons in B6 and NSA mice, as assessed by ANOVA. The NSA were not significantly different than previously examined ICR mice, but the B6 had fewer vacuolated neurons than either of the two outbred strains. 5. In the second experiment, male NSA, ICR, and B6 mice were injected systemically with a high dose, 10 mg/kg, of MK-801. This dose has been demonstrated to result in necrosis in the same population of neurons injured by lower doses of MK-801. 6. An ANOVA indicated that there was a significant difference among the three strains of mice, and a Fisher's protected t revealed that the B6 mice were significantly different from both the NSA and ICR, but that, with our test, those two strains were indistinguishable. 7. Male ICR, NSA, and B6 mice were tested in the holeboard food search task 5 hours after 1 mg/kg of MK-801. There were significant differences between the strains in performance both pre and posttreatment. The effect of the drug was not statistically significant. 8. These results suggest that there may be a genetically mediated difference in the reaction to NMDA
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-22
...- Migration' Variances (Renewal), EPA ICR Number 1353.09, OMB Control Number 2050-0062 AGENCY: Environmental... docket, go to http://www.regulations.gov . Title: Land Disposal Restrictions `No-Migration' Variances... migration.'' The applicant must demonstrate that hazardous wastes can be managed safely in a particular land...
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NASA Astrophysics Data System (ADS)
Nagornov, Konstantin O.; Kozhinov, Anton N.; Tsybin, Yury O.
2018-01-01
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells. During ion detection, ions of the same m/z move in phase for cyclotron ion motion but out of phase for magnetron (drift) ion motion destroying signals at the fundamental and high order harmonics that comprise reduced cyclotron frequency components. After an initial magnetron motion period, ion clouds distribute into a novel type of structures - ion slabs, elliptical cylinders, or star-like structures. These structures rotate at the Larmor (half-cyclotron) frequency on a plane orthogonal to the magnetic field, inducing signals at the true cyclotron frequency on each of the narrow aperture detection electrodes. To eliminate the reduced cyclotron frequency peak upon dipolar ion detection, a number of slabs or elliptical cylinders organizing a star-like configuration are formed. In a NADEL ICR cell with quadrupolar ion detection, a single slab or an elliptical cylinder is sufficient to minimize the intensity of the reduced cyclotron frequency components, particularly the second harmonic. [Figure not available: see fulltext.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
... Program (Renewal); EPA ICR No. 1663.07, OMB Control No. 2060-0376 AGENCY: Environmental Protection Agency... ICR No. 1663.07, OMB Control No. 2060-0376. ICR Status: This ICR is scheduled to expire on July 31...
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78 FR 15720 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-12
... Hazardous Substances Pollution Contingency Plan (NCP) (Renewal); 40 CFR 300.430 and 300.435; was approved on.../29/2016; Approved with change. EPA ICR Number 1093.10; NSPS for Surface Coating of Plastic Parts for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-22
... Heaters (40 CFR Part 60, Subpart AAA) (Renewal)'' (EPA ICR No. 1176.11, OMB Control No. 2060-0161 to the.... Respondent's obligation to respond: Mandatory (40 CFR part 60, subpart AAA) Estimated number of respondents...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-17
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an existing approved Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR, identified as Renewal EPA IRC 0328.16 and OMB Control No. 2050-0021, is scheduled to expire on June 30, 2013. Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.
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Rotation Matrix from the Mean Dynamical Equator and Equinox at J2000.0 to the ICRS
2004-01-01
the ICRS is offset from its equinox by ∆o. The angle 0 is the obliquity of the ecliptic on the ICRS, that is the angle between the ICRS equator and... obliquity is caused solely by a change in the position of the pole of the mean ecliptic . Thus, the sole effect of using the rotating definition of the mean...the mean ecliptic as determined by Chapront et al. from LLR observations (23◦26′21.′′41100 ± 0.′′00005). The angle γy is the separation between the
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-28
... Reports and Voluntary Emission Recall Reports (Renewal) AGENCY: Environmental Protection Agency (EPA... request (ICR), Engine Emission Defect Information Reports and Voluntary Emission Recall Reports (EPA ICR... recall the engines. Engine manufacturers are required to submit Defect Information Reports (DIRs) if...
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Comprehensive Data Collected from the Petroleum Refining Sector
On April 1, 2011 EPA sent a comprehensive industry-wide information collection request (ICR) to all facilities in the U.S. petroleum refining industry. EPA has received this ICR data and compiled these data into databases and spreadsheets for the web
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78 FR 48433 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-08
...; Approved without change. EPA ICR Number 2249.03; Tier 1 Screening of Certain Chemicals Under the Endocrine... Manufacturing and Phosphate Fertilizers Production; 40 CFR part 63 subparts A, AA and BB; was approved on 07/25...
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77 FR 61598 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-10
... the Paperwork Reduction Act (44 U.S.C. 3501 et. seq.). An agency may not conduct or sponsor, and a... without change. EPA ICR Number 1976.05; NESHAP for Reinforced Plastic Composites Production; 40 CFR part...
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77 FR 29334 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-17
.../2012. EPA ICR Number 1611.09; NESHAP for Chromium Emissions from Hard and Decorative Chromium Electroplating and Chromium Anodizing Tanks; in 40 CFR part 63 subparts A and N; OMB filed comment on 04/04/2012...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-13
... Activities; Submission to OMB for Review and Approval; Comment Request; NSPS for Kraft Pulp Mills (Renewal... electronic docket, go to www.regulations.gov . Title: NSPS for Kraft Pulp Mills (Renewal). ICR Numbers: EPA... information. Respondents/Affected Entities: Owners and operators of kraft pulp mills. Estimated Number of...
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76 FR 26284 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-06
... 2060-0264; expires on 04/30/2014; Approved without change. EPA ICR Number 1080.13; NESHAP for Benzene Emission from Benzene Storage Vessels and Coke By Product Recovery Plants; 40 CFR part 61, subparts A and L...
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77 FR 66830 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-07
... Ignition Internal Combustion Engines; 40 CFR part 60 subparts A and IIII; was approved on 10/03/2012; OMB...-0686; expires on 10/31/2015; Approved with change. EPA ICR Number 1617.07; Servicing of Motor Vehicle...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-10
...In compliance with the Paperwork Reduction Act (PRA), this document announces that EPA is planning to submit a request to renew an existing approved Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR is scheduled to expire on November 30, 2012. Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.
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Monitoring the physicochemical degradation of coconut water using ESI-FT-ICR MS.
Costa, Helber B; Souza, Lindamara M; Soprani, Letícia C; Oliveira, Bruno G; Ogawa, Elizângela M; Korres, Adriana M N; Ventura, José A; Romão, Wanderson
2015-05-01
Fresh and aged coconut water (CW) samples were introduced directly into the electrospray ionisation (ESI) source, and were combined with the Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) technique to characterise in situ chemical compounds produced during natural ageing (from 0 to 15 days) at room temperature (23 °C). The ESI-FT-ICR MS readings were acquired and the data were correlated to conventional methodologies: pH, total titratable acidity (TA), total soluble solids, microbial analyses, and ultraviolet visibility (UV-vis) spectroscopy analysis. In general, the pH and TA values changed after 3 days of storage making the CW unsuitable for consumption. The ESI(-)-FT-ICR data also showed a clear and evident change in the chemical profile of CW after 3 days of ageing in the m/z 150-250 and 350-450 regions. Initially, the relative intensity of the natural markers (the m/z 215 and 377 ions-sugar molecules) decreases as a function of ageing time, with the last marker disappearing after 3 days of ageing. New chemical species were then identified such as: citric (m/z 191), galacturonic (m/z 193), gluconic (m/z 195), and saccharic (m/z 209) acids. ESI(-)-FT-ICR MS is a powerful tool to predict the physicochemical properties of CW, such as the pH and TA, where species such as fructose, glucose, sucrose, and gluconic acid can be used as natural markers to monitor the quality of the fruits. Copyright © 2014 Elsevier Ltd. All rights reserved.
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76 FR 77225 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-12
... Intake Structures; was approved on 11/04/2011; OMB Number 2040-0283; expires on 07/31/2013; Approved... Requirements under the Underground Injection Control (UIC) Program for Carbon Dioxide Geologic Sequestration... filed comment on 11/10/2011. EPA ICR Number 2060.05; Cooling Water Intake Structures Existing Facility...
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The United States Environmental Protection Agency (U.S. EPA) instituted a formal regulation negotiation process in 1992 to develop the Disinfectant/Disinfection By-Product (D/DBP) Rule.1 The Advisory Committee that was established to negotiate the regulation included represent...
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78 FR 9045 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-07
... Phosphate Fertilizer Industry; 40 CFR part 60, subparts T, U, V, W and X; was approved on 01/30/2013; OMB.... EPA ICR Number 2323.05; NESHAP for Chemical Manufacturing Area Sources; 40 CFR part 63, subparts A and...
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Sudasinghe, Nilusha; Cort, John R.; Hallen, Richard
2014-12-01
Hydrothermal liquefaction (HTL) crude oil and hydrotreated product from pine tree farm waste (forest product residual, FPR) have been analyzed by direct infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) in both positive- and negative-ionization modes and high-resolution twodimensional heteronuclear 1H-13C NMR spectroscopy. FT-ICR MS resolves thousands of compounds in complex oils and provides unparalleled compositional details for individual molecules for identification of compound class (heteroatom content), type (number of rings plus double bonds to carbon or double bond equivalents (DBE) and carbon number (degree of alkylation). Heteronuclear 1H-13C NMR spectroscopy provides one-bond and multiple-bondmore » correlations between pairs of 1H and 13C chemical shifts that are characteristic of different organic functional groups. Taken together this information provides a picture of the chemical composition of these oils. Pyrolysis crude oil product from pine wood was characterized for comparison. Generally, pyrolysis oil is comprised of a more diverse distribution of heteroatom classes with higher oxygen number relative to HTL oil as shown by both positive- and negative-ion ESI FT-ICR MS. A total of 300 N1, 594 O1 and 267 O2 compounds were observed as products of hydrotreatment. The relative abundance of N1O1, N1O2, N1O3, N2, N2O1, N2O2 and O3 compounds are reduced to different degrees after hydrotreatment and other higher heteroatom containing species (O4-O10, N1O4, N1O5 and N2O3) are completely removed by hydrotreatment.« less
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-29
... Nonroad Engines and Recreational Vehicles AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... this action are importers into the United States of nonroad engines and vehicles. Title: Reporting and Recordkeeping Requirements for Importation of Nonroad Engines and Recreational Vehicles (Renewal). ICR numbers...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-16
... Program Fees (Renewal); EPA ICR No. 2080.04, OMB Control No. 2060-0545 AGENCY: Environmental Protection.... 2060-0545. ICR Status: This ICR is scheduled to expire on July 31, 2010. Under OMB regulations, the...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-22
... Additives: Requirements for Manufacturers (Renewal); EPA ICR No. 0309.13, OMB Control No. 2060-0150 AGENCY... No. 2060-0150. ICR Status: This ICR is scheduled to expire on July 31, 2010. Under OMB regulations...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-24
... Report (Reinstatement); EPA ICR No. 1812.04 OMB Control No. 2020-0020 AGENCY: Environmental Protection.... 2020-0020. ICR Status: This is a request to reinstate an ICR that expired on June 30, 2008. An Agency...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-08-18
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an existing Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR is scheduled to expire on December 31, 2011. Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-16
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an existing approved Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR is scheduled to expire on April 30, 2012. Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.
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Comparative study of peripheral neuropathy and nerve regeneration in NOD and ICR diabetic mice.
Homs, Judit; Ariza, Lorena; Pagès, Gemma; Verdú, Enrique; Casals, Laura; Udina, Esther; Chillón, Miguel; Bosch, Assumpció; Navarro, Xavier
2011-09-01
The non-obese diabetic (NOD) mouse was suggested as an adequate model for diabetic autonomic neuropathy. We evaluated sensory-motor neuropathy and nerve regeneration following sciatic nerve crush in NOD males rendered diabetic by multiple low doses of streptozotocin, in comparison with similarly treated Institute for Cancer Research (ICR) mice, a widely used model for type I diabetes. Neurophysiological values for both strains showed a decline in motor and sensory nerve conduction velocity at 7 and 8 weeks after induction of diabetes in the intact hindlimb. However, amplitudes of compound muscle and sensory action potentials (CMAPs and CNAPs) were significantly reduced in NOD but not in ICR diabetic mice. Morphometrical analysis showed myelinated fiber loss in highly hyperglycemic NOD mice, but no significant changes in fiber size. There was a reduction of intraepidermal nerve fibers, more pronounced in NOD than in ICR diabetic mice. Interestingly, aldose reductase and poly(ADP-ribose) polymerase (PARP) activities were increased already at 1 week of hyperglycemia, persisting until the end of the experiment in both strains. Muscle and nerve reinnervation was delayed in diabetic mice following sciatic nerve crush, being more marked in NOD mice. Thus, diabetes of mid-duration induces more severe peripheral neuropathy and slower nerve regeneration in NOD than in ICR mice. © 2011 Peripheral Nerve Society.
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77 FR 22776 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-17
... for Pulp and Paper Production; in 40 CFR part 63 subparts A and S; OMB filed comment on 03/02/2012...; OMB filed comment on 03/02/2012. EPA ICR Number 1811.08; NESHAP for Polyether Polyol Production; in 40... Number 2313.02; Ambient Ozone Monitoring Regulations: Revisions to Network Design Requirements (Final...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-22
... Activities; Proposed Collection; Comment Request; Drug Testing for Contract Employees (Renewal) AGENCY... electronic docket, go to www.regulations.gov . Title: Drug Testing for Contract Employees. ICR numbers: EPA..., amphetamines, phencyclidine (PCP), and any other controlled substances. The testing for drugs must be completed...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-06
... contents of the docket, and to access those documents in the public docket that are available..., including through the use of appropriate automated electronic, mechanical, or other technological collection... as State, local, or Tribal governments. Title: RCRA Expanded Public Participation. ICR numbers: EPA...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-28
... Activities; Proposed Collection; Comment Request; Contractor Cumulative Claim and Reconciliation (Renewal... identify the Docket ID Number EPA-HQ-OARM-2011-0997, Contractor Cumulative Claim and Reconciliation. Hand... information collection activity or ICR does this apply to? Affected entities: All contractors who have...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-14
... Emissions From New and In-Use Portable Gasoline Containers (Renewal), EPA ICR 2213.02, OMB Control No. 2060.... 2213.03, OMB Control No. 2060-0597. ICR status: This ICR is currently scheduled to expire on June 30...
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Substance Identification Information from EPA's Substance Registry
The Substance Registry Services (SRS) is the authoritative resource for basic information about substances of interest to the U.S. EPA and its state and tribal partners. Substances, particularly chemicals, can have many valid synonyms. For example, toluene, methyl benzene, and phenyl methane, are commonly used names for the same chemical. EPA programs collect environmental data for this chemical using each of these names, plus others. This diversity leads to problems when a user is looking for programmatic data for toluene but is unaware that the data is stored under the synonym methyl benzene. For each substance, the SRS identifies the statutes, EPA programs, as well as organization external to EPA, that track or regulate that substance and the synonym used by that statute, EPA program or external organization. Besides standardized information for each chemical, such as the Chemical Abstracts Services name and the Chemical Abstracts Number and the EPA Registry Name (the EPA standard name), the SRS also includes additional information, such as molecular weight and molecular formula. Additionally, an SRS Internal Tracking Number uniquely identifies each substance, enabling cross-walking between synonyms. EPA is providing a large .ZIP file providing the SRS data in CSV format, and a separate small metadata file in XML containing the field names and definitions.
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76 FR 63295 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-12
... the Office of Management and Budget (OMB) responses to Agency Clearance requests, in compliance with...; Underground Storage Tanks: Technical and Financial Requirements, and State Program Approval Procedures; 40 CFR... with change. EPA ICR Number 2028.06; NESHAP for Industrial, Commercial, and Institutional Boilers and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-14
... EPA will not know your identity or contact information unless you provide it in the body of your... recommends that you include your name and other contact information in the body of your comment and with any... Control No. 2060-0243. For the Part 71 regulations, EPA ICR No. 1713.10 and OMB Control No. 2060-0336. ICR...
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Top-down mass spectrometry imaging of intact proteins by laser ablation ESI FT-ICR MS.
Kiss, András; Smith, Donald F; Reschke, Brent R; Powell, Matthew J; Heeren, Ron M A
2014-05-01
Laser ablation ESI (LAESI) is a recent development in MS imaging. It has been shown that lipids and small metabolites can be imaged in various samples such as plant material, tissue sections or bacterial colonies without any sample pretreatment. Further, LAESI has been shown to produce multiply charged protein ions from liquids or solid surfaces. This presents a means to address one of the biggest challenges in MS imaging; the identification of proteins directly from biological tissue surfaces. Such identification is hindered by the lack of multiply charged proteins in common MALDI ion sources and the difficulty of performing tandem MS on such large, singly charged ions. We present here top-down identification of intact proteins from tissue with a LAESI ion source combined with a hybrid ion-trap FT-ICR mass spectrometer. The performance of the system was first tested with a standard protein with electron capture dissociation and infrared multiphoton dissociation fragmentation to prove the viability of LAESI FT-ICR for top-down proteomics. Finally, the imaging of a tissue section was performed, where a number of intact proteins were measured and the hemoglobin α chain was identified directly from tissue using CID and infrared multiphoton dissociation fragmentation. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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75 FR 17710 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-07
... ENVIRONMENTAL PROTECTION AGENCY [FRL-9134-4] Agency Information Collection Activities OMB...-0635; expires on 03/31/2013; Approved without change. EPA ICR Number 1060.15; NSPS for Steel Plants... Division. [FR Doc. 2010-7873 Filed 4-6-10; 8:45 am] BILLING CODE 6560-50-P ...
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Lakshmanan, Rajeswari; Wolff, Jeremy J.; Alvarado, Rudy; Loo, Joseph A.
2014-01-01
A comparison of different data-independent fragmentation methods combined with liquid chromatography (LC) coupled to high resolution Fourier-transform ion cyclotron resonance (FT-ICR) tandem mass spectrometry (MS) is presented for top-down MS of protein mixtures. Proteins composing the 20S and 19S proteasome complex and their post-translational modifications were identified using a 15-Tesla FT-ICR mass spectrometer. The data-independent fragmentation modes with LC timescales allowed for higher duty cycle measurements that better suit on-line LC-FT-ICR-MS. Protein top-down dissociation was effected by funnel-skimmer collisionally activated dissociation (FS-CAD) and CASI (Continuous Accumulation of Selected Ions)-CAD. The N-terminus for 9 out of the 14 20S proteasome proteins were found to be modified, and the α3 protein was found to be phosphorylated; these results are consistent with previous reports. Mass measurement accuracy with the LC-FT-ICR system for the 20–30 kDa 20S proteasome proteins was 1 ppm. The intact mass of the 100 kDa Rpn1 subunit from the 19S proteasome complex regulatory particle was measured with a deviation of 17 ppm. The CASI-CAD technique is a complementary tool for intact protein fragmentation and is an effective addition to the growing inventory of dissociation methods which are compatible with on-line protein separation coupled to FT-ICR MS. PMID:24478249
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EPA GAS PHASE CHEMISTRY CHAMBER STUDIES
Gas-phase smog chamber experiments are being performed at EPA in order to evaluate a number of current chemical mechanisms for inclusion in EPA regulatory and research models. The smog chambers are 9000 L in volume and constructed of 2-mil teflon film. One of the chambers is co...
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Mercury in US coal: Observations using the COALQUAL and ICR data
Quick, J.C.; Brill, T.C.; Tabet, D.E.
2003-01-01
The COALQUAL data set lists the mercury content of samples collected from the in-ground US coal resource, whereas the ICR data set lists the mercury content of samples collected from coal shipments delivered to US electric utilities. After selection and adjustment of records, the COALQUAL data average 0.17 ??g Hg/g dry coal or 5.8 kg Hg/PJ, whereas the ICR data average 0.10 ??g Hg/g dry coal or 3.5 kg Hg/PJ. Because sample frequency does not correspond to the inground or produced tonnage, these values are not accurate estimates of the mercury content of either in-ground or delivered US coal. Commercial US coal contains less mercury than previously estimated, and its mercury content has declined during the 1990s. Selective mining and more extensive coal washing may accelerate the current trend towards lower mercury content in coal burned at US electric utilities.
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[Effects of postnatal lambda-cyhalothrin exposure on synaptic proteins in ICR mouse brain].
Bao, Xun-Di; Wang, Qu-Nan; Li, Fang-Fang; Chai, Xiao-Yu; Gao, Ye
2011-04-01
To evaluate the influence on the synaptic protein expression in different brain regions of ICR mice after lambda-cyhalothrin (LCT) exposure during postnatal period. Two male and 4 female healthy ICR mice were put in one cage. It was set as pregnancy if vaginal plug was founded. Offspring were divided into 5 groups randomly, and exposed to LCT (0.01% DMSO solution) at the doses of 0.1, 1.0 and 10.0 mg/kg by intragastric rout every other day from postnatal days (PND) 5 to PND13, control animals were treated with normal saline or DMSO by the same route. The brains were removed from pups on PND 14, the synaptic protein expression levels in cortex, hippocampus and striatum were measured by western blot. GFAP levels of cortex and hippocampus in the LCT exposure group increased with doses, as compared with control group (P < 0.05), while Tuj protein expression did not change significantly in the various brain regions of ICR mice. GAP-43 protein expression levels in the LCT exposed mouse hippocampus and in female ICR mouse cortex increased with doses, as compared with control group (P < 0.05). Presynaptic protein (Synapsin I) expression levels did not change obviously in various brain regions. However, postsynaptic density protein 95 (PSD95) expression levels of the hippocampus and striatum in male offspring of 10.0 mg/kg LCT group, of cortex of female LCT groups, and of female offspring in all exposure groups, of striatum, in 1.0 or 10.0 mg/kg LCT exposure groups significantly decreased (P < 0.05). Early postnatal exposure to LCT affects synaptic protein expression. These effects may ultimately affect the construction of synaptic connections.
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In vivo irritation study of Melastoma malabathricum cream formulation on ICR mice
NASA Astrophysics Data System (ADS)
Yasin, Rabiahtul Adarwiyah Mohd; Jemon, Khairunadwa; Nor, Norefrina Shafinaz Md
2016-11-01
Melastoma malabathricum is a traditional herb that is used to treat wound on skin. It has also been proven to have antiviral activity against Herpes Simplex virus type 1 (HSV-1). In this study, M. malabathricum cream formulation was developed by incorporating M. malabathricum aqueous extract into cream base. The safety and biocompatibility of the formulated cream was investigated by topically applying the cream onto the back of ICR mice skin. Treatment with M. malabathricum was found to accelerate wound contraction with less scar formation. The effect of M. malabathricum has prompted a possibility that M. malabathricum might contribute in enhancing the healing process of cutaneous lesion caused by HSV-1. The formulated cream did not cause any skin irritation or adverse effect to ICR mice when topically applied within seven days of exposure.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-17
... Phosphoric Acid Manufacturing and Phosphate Fertilizers Production (40 CFR Part 63, Subparts AA and BB). ICR... September 30, 2013. (33) Docket ID Number: EPA-HQ-OECA-2012-0686. Title: NESHAP for Organic Liquids... Acid Manufacturing and Phosphate Fertilizers Production (40 CFR Part 63, Subparts AA and BB); Learia...
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THE OCCURRENCE OF A NEW GENERATION OF DBPS (BEYOND THE ICR)
A nationwide survey of 12 full-scale treatment plants for disinfection by-products (DBPs) was initiated in the U.S. in 2000. Approximately 50DBPs that rated a high priority for potential toxicity and were not included in the Information Collection Rule (ICR) are being quantified...
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40 CFR 265.11 - Identification number.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...
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40 CFR 265.11 - Identification number.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...
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40 CFR 265.11 - Identification number.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...
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40 CFR 265.11 - Identification number.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...
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40 CFR 265.11 - Identification number.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...
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40 CFR 264.11 - Identification number.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...
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40 CFR 264.11 - Identification number.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...
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40 CFR 264.11 - Identification number.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...
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40 CFR 264.11 - Identification number.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...
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40 CFR 264.11 - Identification number.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...
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75 FR 56528 - EPA's Role in Advancing Sustainable Products
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-16
... services (NAICS code 72). Other services, except public administration (NAICS code 81). Public... Rm. 3334, EPA West Bldg., 1301 Constitution Ave., NW., Washington, DC. The EPA/DC Public Reading Room... holidays. The telephone number of the EPA/DC Public Reading Room is (202) 566-1744, and the telephone...
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A novel mice model of metabolic syndrome: the high-fat-high-fructose diet-fed ICR mice.
Zhuhua, Zhang; Zhiquan, Wang; Zhen, Yang; Yixin, Niu; Weiwei, Zhang; Xiaoyong, Li; Yueming, Liu; Hongmei, Zhang; Li, Qin; Qing, Su
2015-01-01
Currently, the metabolic syndrome (MS) is occurring at growing rates worldwide, raising extensive concerns on the mechanisms and therapeutic interventions for this disorder. Herein, we described a novel method of establishing MS model in rodents. Male Institute of Cancer Research (ICR) mice were fed with high-fat-high-fructose (HFHF) diet or normal chow (NC) respectively for 12 weeks. Metabolic phenotypes were assessed by glucose tolerance test, insulin tolerance test and hyperinsulinemic-euglycemic clamp. Blood pressure was measured by a tail-cuff system. At the end of the experiment, mice were sacrificed, and blood and tissues were harvested for subsequent analysis. Serum insulin levels were measured by ELISA, and lipid profiles were determined biochemically. The HFHF diet-fed ICR mice exhibited obvious characteristics of the components of MS, including obvious obesity, severe insulin resistance, hyperinsulinemia, dislipidemia, significant hypertension and hyperuricemia. Our data suggest that HFHF diet-fed ICR mice may be a robust and efficient animal model that could well mimic the basic pathogenesis of human MS.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-02
... Utility Steam Generating Units (40 CFR Part 60, Subpart Da) (Renewal)'' (EPA ICR No. 1053.11, OMB Control..., and any changes, or additions to the Provisions, are specified at 40 CFR part 60, subpart Da. Owners... part 60, subpart Da). Estimated number of respondents: 710 (total). Frequency of response: Initially...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-12
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request for a new Information Collection Request (ICR) to the Office of Management and Budget (OMB). Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-29
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request for a new Information Collection Request (ICR) to the Office of Management and Budget (OMB). Before submitting the ICR to OMB for review and approval, EPA is soliciting public comments on specific aspects of the proposed information collection as described below.
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Azzi, Salah; Steunou, Virginie; Tost, Jörg; Rossignol, Sylvie; Thibaud, Nathalie; Das Neves, Cristina; Le Jule, Marilyne; Habib, Walid Abi; Blaise, Annick; Koudou, Yves; Busato, Florence; Le Bouc, Yves; Netchine, Irène
2015-01-01
The structural organisation of the human IGF2/ICR1/H19 11p15 domain is very complex, and the mechanisms underlying its regulation are poorly understood. The Imprinted Center Region 1 (ICR1) contains seven binding sites for the zinc-finger protein CTCF (CBS: CTCF Binding Sites); three additional differentially methylated regions (DMR) are located at the H19 promoter (H19DMR) and two in the IGF2 gene (DMR0 and DMR2), respectively. Loss of imprinting at the IGF2/ICR1/H19 domain results in two growth disorders with opposite phenotypes: Beckwith-Wiedemann syndrome and Russell Silver syndrome (RSS). Despite the IGF2/ICR1/H19 locus being widely studied, the extent of hypomethylation across the domain remains not yet addressed in patients with RSS. We assessed a detailed investigation of the methylation status of the 11p15 ICR1 CBS1-7, IGF2DMR0 and H19DMR (H19 promoter) in a population of controls (n=50) and RSS carrying (n=104) or not (n=65) carrying a hypomethylation at the 11p15 ICR1 region. The methylation indexes (MI) were balanced at all regions in the control population and patients with RSS without any as yet identified molecular anomaly. Interestingly, patients with RSS with ICR1 hypomethylation showed uneven profiles of methylation among the CBSs and DMRs. Furthermore, normal MIs at CBS1 and CBS7 were identified in 9% of patients. The hypomethylation does not spread equally throughout the IGF2/ICR1/H19 locus, and some loci could have normal MI, which may lead to underdiagnosis of patients with RSS with ICR1 hypomethylation. The uneven pattern of methylation suggests that some CBSs may play different roles in the tridimensional chromosomal looping regulation of this locus. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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Ultrahigh-resolution FT-ICR mass spectrometry characterization of a-pinene ozonolysis SOA
Secondary organic aerosol (SOA) of α-pinene ozonolysis with and without hydroxyl radical scavenging hexane was characterized by ultrahigh-resolution. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Molecular formulas for more than 900 negative ions were i...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-04
... 2060-0038 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with... 2060-0038. ICR Status: This ICR is scheduled to expire on March 31, 2010. Under OMB [[Page 5787...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-13
...The Environmental Protection Agency has submitted an information collection request (ICR), ``NSPS for Stationary Gas Turbines (Renewal)'' (EPA ICR No. 1071.11, OMB Control No. 2060-0028), to the Office of Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act (44 U.S.C. 3501 et seq). This is a proposed extension of the ICR, which is currently approved through December 31, 2013. Public comments were previously requested via the Federal Register (78 FR 33409) on June 4, 2013, during a 60-day comment period. This notice allows for an additional 30 days for public comments. A fuller description of the ICR is given below, including its estimated burden and cost to the public. An Agency may not conduct or sponsor and a person is not required to respond to a collection of information unless it displays a currently valid OMB control number.
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NASA Astrophysics Data System (ADS)
Blake, Samantha L.; Walker, S. Hunter; Muddiman, David C.; Hinks, David; Beck, Keith R.
2011-12-01
Color Index Disperse Yellow 42 (DY42), a high-volume disperse dye for polyester, was used to compare the capabilities of the LTQ-Orbitrap XL and the LTQ-FT-ICR with respect to mass measurement accuracy (MMA), spectral accuracy, and sulfur counting. The results of this research will be used in the construction of a dye database for forensic purposes; the additional spectral information will increase the confidence in the identification of unknown dyes found in fibers at crime scenes. Initial LTQ-Orbitrap XL data showed MMAs greater than 3 ppm and poor spectral accuracy. Modification of several Orbitrap installation parameters (e.g., deflector voltage) resulted in a significant improvement of the data. The LTQ-FT-ICR and LTQ-Orbitrap XL (after installation parameters were modified) exhibited MMA ≤ 3 ppm, good spectral accuracy (χ2 values for the isotopic distribution ≤ 2), and were correctly able to ascertain the number of sulfur atoms in the compound at all resolving powers investigated for AGC targets of 5.00 × 105 and 1.00 × 106.
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A novel mice model of metabolic syndrome: the high-fat-high-fructose diet-fed ICR mice
Zhuhua, Zhang; Zhiquan, Wang; Zhen, Yang; Yixin, Niu; Weiwei, Zhang; Xiaoyong, Li; Yueming, Liu; Hongmei, Zhang; Li, Qin; Qing, Su
2015-01-01
Currently, the metabolic syndrome (MS) is occurring at growing rates worldwide, raising extensive concerns on the mechanisms and therapeutic interventions for this disorder. Herein, we described a novel method of establishing MS model in rodents. Male Institute of Cancer Research (ICR) mice were fed with high-fat-high-fructose (HFHF) diet or normal chow (NC) respectively for 12 weeks. Metabolic phenotypes were assessed by glucose tolerance test, insulin tolerance test and hyperinsulinemic-euglycemic clamp. Blood pressure was measured by a tail-cuff system. At the end of the experiment, mice were sacrificed, and blood and tissues were harvested for subsequent analysis. Serum insulin levels were measured by ELISA, and lipid profiles were determined biochemically. The HFHF diet-fed ICR mice exhibited obvious characteristics of the components of MS, including obvious obesity, severe insulin resistance, hyperinsulinemia, dislipidemia, significant hypertension and hyperuricemia. Our data suggest that HFHF diet-fed ICR mice may be a robust and efficient animal model that could well mimic the basic pathogenesis of human MS. PMID:26134356
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Collision cross section measurements for biomolecules within a high-resolution FT-ICR cell: theory.
Guo, Dan; Xin, Yi; Li, Dayu; Xu, Wei
2015-04-14
In this study, an energetic hard-sphere ion-neutral collision model was proposed to bridge-link ion collision cross section (CCS) with the image current collected from a high-resolution Fourier transform ion cyclotron resonance (FT-ICR) cell. By investigating the nonlinear effects induced by high-order electric fields and image charge forces, the energetic hard-sphere collision model was validated through experiments. Suitable application regions for the energetic hard-sphere collision model, as well as for the conventional Langevin and hard-sphere collision models, were also discussed. The energetic hard-sphere collision model was applied in the extraction of ion CCSs from high-resolution FT-ICR mass spectra. Discussions in the present study also apply to FT-Orbitraps and FT-quadrupole ion traps.
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77 FR 14777 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-13
....06; NESHAP for Beryllium Rocket Motor Fuel Firing (Renewal); 40 CFR part 61 subparts A and D; was... from New Motor Vehicles: Heavy-Duty Engine and Vehicle Standards (Final Rule); 40 CFR parts 86, 523.... EPA ICR Number 1557.08; NSPS for Municipal Solid Waste Landfills; 40 CFR part 60 subparts A and WWW...
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Chemical Analysis of Water-accommodated Fractions of Crude Oil Spills Using TIMS-FT-ICR MS.
Benigni, Paolo; Marin, Rebecca; Sandoval, Kathia; Gardinali, Piero; Fernandez-Lima, Francisco
2017-03-03
Multiple chemical processes control how crude oil is incorporated into seawater and also the chemical reactions that occur overtime. Studying this system requires the careful preparation of the sample in order to accurately replicate the natural formation of the water-accommodated fraction that occurs in nature. Low-energy water-accommodated fractions (LEWAF) are carefully prepared by mixing crude oil and water at a set ratio. Aspirator bottles are then irradiated, and at set time points, the water is sampled and extracted using standard techniques. A second challenge is the representative characterization of the sample, which must take into consideration the chemical changes that occur over time. A targeted analysis of the aromatic fraction of the LEWAF can be performed using an atmospheric-pressure laser ionization source coupled to a custom-built trapped ion mobility spectrometry-Fourier transform-ion cyclotron resonance mass spectrometer (TIMS-FT-ICR MS). The TIMS-FT-ICR MS analysis provides high-resolution ion mobility and ultrahigh-resolution MS analysis, which further allow the identification of isomeric components by their collision cross-sections (CCS) and chemical formula. Results show that as the oil-water mixture is exposed to light, there is significant photo-solubilization of the surface oil into the water. Over time, the chemical transformation of the solubilized molecules takes place, with a decrease in the number of identifications of nitrogen- and sulfur-bearing species in favor of those with a greater oxygen content than were typically observed in the base oil.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-22
...The Environmental Protection Agency has submitted an information collection request (ICR), ``NESHAP for Stationary Combustion Turbines (40 CFR Part 63, Subpart YYYY) (Renewal)'' (EPA ICR No. 1967.05, OMB Control No. 2060-0540) to the Office of Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act (44 U.S.C. 3501 et seq). This is a proposed extension of the ICR, which is currently approved through September 30, 2013. Public comments were previously requested via the Federal Register (77 FR 63813) on October 17, 2012, during a 60-day comment period. This notice allows for an additional 30 days for public comments. A fuller description of the ICR is given below, including its estimated burden and cost to the public. An Agency may not conduct or sponsor and a person is not required to respond to a collection of information unless it displays a currently valid OMB control number.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-22
... System of Records; EPA Parking Control Office File (EPA-10) and EPA Transit and Guaranteed Ride Home Program Files (EPA-35) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency (EPA) is deleting the systems of records for EPA Parking Control Office File...
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76 FR 68747 - Agency Information Collection Activities OMB Responses
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-07
... Polymeric Coating of Supporting Substrates Facilities; 40 CFR part 60, subparts A and VVV; was approved on....10; Oil Pollution Act Facility Response Plans (Renewal); 40 CFR 112.20 and 112.21; was approved on 10... comment on 10/25/2011. EPA ICR Number 2439.01; NESHAP for Natural Gas Transmission and Storage; in 40 CFR...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-29
... ID No. EPA-HQ-OEI- 2011-0096, to (1) EPA online using http://www.regulations.gov (our preferred... a public docket for this ICR under Docket ID No. EPA-HQ-OEI-2011-0096, which is available for online..., technology-neutral framework for electronic reporting across all EPA programs; allow EPA programs to offer...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-25
...-2012-0034, to: (1) EPA online using www.regulations.gov (our preferred method), or by email to docket... decrease in the labor hours in this ICR compared to the previous ICR due to a mathematical error in [[Page...
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Cho, Yunju; Birdwell, Justin E.; Hur, Manhoi; Lee, Joonhee; Kim, Byungjoo; Kim, Sunghwan
2017-01-01
In this study, comprehensive two-dimensional (2D) gas chromatography–mass spectrometry (GC–MS), atmospheric pressure photoionization (APPI) quadrupole-Orbitrap mass spectrometry (MS), and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) were used to study the aromatic fractions of crude oil and oil shale pyrolysates (shale oils). The collected data were compared and combined in the double bond equivalence (DBE) versus carbon number plot to obtain a more complete understanding of the composition of the oil fractions. The numbers of peaks observed by each technique followed the order 2D GC–MS < Orbitrap MS < FT-ICR MS. The class distributions observed by Orbitrap MS and FT-ICR MS were similar to each other but different from that observed by 2D GC–MS. The DBE and carbon number distributions of the 2D GC–MS and Orbitrap MS data were similar for crude oil aromatics. The FT-ICR MS plots of DBE and carbon number showed an extended range of higher values relative to the other methods. For the aromatic fraction of an oil shale pyrolysate generated by the Fischer assay, only a few nitrogen-containing compounds were observed by 2D GC–MS but a large number of these compounds were detected by Orbitrap MS and FT-ICR MS. This comparison clearly shows that the data obtained from these three techniques can be combined to more completely characterize oil composition. The data obtained by Orbitrap MS and FT-ICR MS agreed well with one another, and the combined DBE versus carbon number plot provided more complete coverage of compounds present in the fractions. In addition, the chemical structure information provided by 2D GC–MS could be matched with the chemical formulas in the DBE versus carbon number plots, providing information not available in ultrahigh-resolution MS results. It was therefore concluded that the combination of 2D GC–MS, Orbitrap MS, and FT-ICR MS in the DBE versus carbon number space facilitates structural assignment of heavy
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Anderson, Lissa C; DeHart, Caroline J; Kaiser, Nathan K; Fellers, Ryan T; Smith, Donald F; Greer, Joseph B; LeDuc, Richard D; Blakney, Greg T; Thomas, Paul M; Kelleher, Neil L; Hendrickson, Christopher L
2017-02-03
Successful high-throughput characterization of intact proteins from complex biological samples by mass spectrometry requires instrumentation capable of high mass resolving power, mass accuracy, sensitivity, and spectral acquisition rate. These limitations often necessitate the performance of hundreds of LC-MS/MS experiments to obtain reasonable coverage of the targeted proteome, which is still typically limited to molecular weights below 30 kDa. The National High Magnetic Field Laboratory (NHMFL) recently installed a 21 T FT-ICR mass spectrometer, which is part of the NHMFL FT-ICR User Facility and available to all qualified users. Here we demonstrate top-down LC-21 T FT-ICR MS/MS of intact proteins derived from human colorectal cancer cell lysate. We identified a combined total of 684 unique protein entries observed as 3238 unique proteoforms at a 1% false discovery rate, based on rapid, data-dependent acquisition of collision-induced and electron-transfer dissociation tandem mass spectra from just 40 LC-MS/MS experiments. Our identifications included 372 proteoforms with molecular weights over 30 kDa detected at isotopic resolution, which substantially extends the accessible mass range for high-throughput top-down LC-MS/MS.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-07
... Sector Residual Risk and Technology Review (RTR); EPA ICR No. 2393.01, OMB Control No. 2060-NEW AGENCY... Officer for EPA, 725 17th Street, NW., Washington, DC 20503. FOR FURTHER INFORMATION CONTACT: Bill Schrock...; e-mail address: schrock.bill@epa.gov . SUPPLEMENTARY INFORMATION: EPA has submitted the following...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-27
... Health and the Environment Under TSCA Section 8(e) AGENCY: Environmental Protection Agency (EPA). ACTION...), ``Notification of Substantial Risk of Injury to Health and the Environment under TSCA Section 8(e)'' (EPA ICR No... health or the environment must immediately inform EPA of such information. EPA routinely disseminates...
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Lou, Haiyi; Lu, Yan; Lu, Dongsheng; Fu, Ruiqing; Wang, Xiaoji; Feng, Qidi; Wu, Sijie; Yang, Yajun; Li, Shilin; Kang, Longli; Guan, Yaqun; Hoh, Boon-Peng; Chung, Yeun-Jun; Jin, Li; Su, Bing; Xu, Shuhua
2015-07-02
Tibetan high-altitude adaptation (HAA) has been studied extensively, and many candidate genes have been reported. Subsequent efforts targeting HAA functional variants, however, have not been that successful (e.g., no functional variant has been suggested for the top candidate HAA gene, EPAS1). With WinXPCNVer, a method developed in this study, we detected in microarray data a Tibetan-enriched deletion (TED) carried by 90% of Tibetans; 50% were homozygous for the deletion, whereas only 3% carried the TED and 0% carried the homozygous deletion in 2,792 worldwide samples (p < 10(-15)). We employed long PCR and Sanger sequencing technologies to determine the exact copy number and breakpoints of the TED in 70 additional Tibetan and 182 diverse samples. The TED had identical boundaries (chr2: 46,694,276-46,697,683; hg19) and was 80 kb downstream of EPAS1. Notably, the TED was in strong linkage disequilibrium (LD; r(2) = 0.8) with EPAS1 variants associated with reduced blood concentrations of hemoglobin. It was also in complete LD with the 5-SNP motif, which was suspected to be introgressed from Denisovans, but the deletion itself was absent from the Denisovan sequence. Correspondingly, we detected that footprints of positive selection for the TED occurred 12,803 (95% confidence interval = 12,075-14,725) years ago. We further whole-genome deep sequenced (>60×) seven Tibetans and verified the TED but failed to identify any other copy-number variations with comparable patterns, giving this TED top priority for further study. We speculate that the specific patterns of the TED resulted from its own functionality in HAA of Tibetans or LD with a functional variant of EPAS1. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
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Lou, Haiyi; Lu, Yan; Lu, Dongsheng; Fu, Ruiqing; Wang, Xiaoji; Feng, Qidi; Wu, Sijie; Yang, Yajun; Li, Shilin; Kang, Longli; Guan, Yaqun; Hoh, Boon-Peng; Chung, Yeun-Jun; Jin, Li; Su, Bing; Xu, Shuhua
2015-01-01
Tibetan high-altitude adaptation (HAA) has been studied extensively, and many candidate genes have been reported. Subsequent efforts targeting HAA functional variants, however, have not been that successful (e.g., no functional variant has been suggested for the top candidate HAA gene, EPAS1). With WinXPCNVer, a method developed in this study, we detected in microarray data a Tibetan-enriched deletion (TED) carried by 90% of Tibetans; 50% were homozygous for the deletion, whereas only 3% carried the TED and 0% carried the homozygous deletion in 2,792 worldwide samples (p < 10−15). We employed long PCR and Sanger sequencing technologies to determine the exact copy number and breakpoints of the TED in 70 additional Tibetan and 182 diverse samples. The TED had identical boundaries (chr2: 46,694,276–46,697,683; hg19) and was 80 kb downstream of EPAS1. Notably, the TED was in strong linkage disequilibrium (LD; r2 = 0.8) with EPAS1 variants associated with reduced blood concentrations of hemoglobin. It was also in complete LD with the 5-SNP motif, which was suspected to be introgressed from Denisovans, but the deletion itself was absent from the Denisovan sequence. Correspondingly, we detected that footprints of positive selection for the TED occurred 12,803 (95% confidence interval = 12,075–14,725) years ago. We further whole-genome deep sequenced (>60×) seven Tibetans and verified the TED but failed to identify any other copy-number variations with comparable patterns, giving this TED top priority for further study. We speculate that the specific patterns of the TED resulted from its own functionality in HAA of Tibetans or LD with a functional variant of EPAS1. PMID:26073780
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-25
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2008-0719, FRL-9118-2] Agency Information Collection Activities; Proposed Collection; Comment Request; Animal Sectors; EPA ICR No. 1989.07; OMB Control No. 2040-0250 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the...
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Work-In-Progress Peer Consult on EPA's Multimedia ...
This document is a compilation of responses from four external peer reviewers on EPA's "Multimedia Exposure Analysis to Inform a Public Health-Based Value for Lead in Drinking Water." It was delivered by Versar, Inc. under contract number EP-C-12-045 Task Order 91. Peer review report compiled, written and delivered by Versar, Inc to EPA.
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Using ICR and SCID mice as animal models for smallpox to assess antiviral drug efficacy.
Titova, Ksenya A; Sergeev, Alexander A; Zamedyanskaya, Alena S; Galahova, Darya O; Kabanov, Alexey S; Morozova, Anastasia A; Bulychev, Leonid E; Sergeev, Artemiy A; Glotova, Tanyana I; Shishkina, Larisa N; Taranov, Oleg S; Omigov, Vladimir V; Zavjalov, Evgenii L; Agafonov, Alexander P; Sergeev, Alexander N
2015-09-01
The possibility of using immunocompetent ICR mice and immunodeficient SCID mice as model animals for smallpox to assess antiviral drug efficacy was investigated. Clinical signs of the disease did not appear following intranasal (i.n.) challenge of mice with strain Ind-3a of variola virus (VARV), even when using the highest possible dose of the virus (5.2 log10 p.f.u.). The 50 % infective doses (ID50) of VARV, estimated by the virus presence or absence in the lungs 3 and 4 days post-infection, were 2.7 ± 0.4 log10 p.f.u. for ICR mice and 3.5 ± 0.7 log10 p.f.u. for SCID mice. After i.n. challenge of ICR and SCID mice with VARV 30 and 50 ID50, respectively, steady reproduction of the virus occurred only in the respiratory tract (lungs and nose). Pathological inflammatory destructive changes were revealed in the respiratory tract and the primary target cells for VARV (macrophages and epithelial cells) in mice, similar to those in humans and cynomolgus macaques. The use of mice to assess antiviral efficacies of NIOCH-14 and ST-246 demonstrated the compliance of results with those described in scientific literature, which opens up the prospect of their use as an animal model for smallpox to develop anti-smallpox drugs intended for humans.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-24
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPPT-2009-0929; FRL-8806-1] Agency Information Collection Activities; Proposed Collection; Comment Request; Request for Contractor Access to TSCA CBI; EPA ICR No. 1250.09, OMB Control No. 2070-0075 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-27
... Policy Act and Assessing the Environmental Effects Abroad of EPA Actions (Renewal); EPA ICR No. 2243.06... National Environmental Policy Act and Assessing the Environmental Effects Abroad of EPA Actions (Renewal... ``Procedures for Implementing the National Environmental Policy Act and Assessing the Environmental Effects...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-15
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2006-0394; FRL-9103-7; EPA ICR No. 1569.07; OMB Control...; Comment Request; Approval of State Coastal Nonpoint Pollution Control Programs (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-26
...., Washington, DC 20503. FOR FURTHER INFORMATION CONTACT: Nell Orscheln, Oceans and Coastal Protection Division... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2006-0369; FRL-9107-1] Agency Information Collection...); EPA ICR No. 1500.07, OMB Control No. 2040-0138 AGENCY: Environmental Protection Agency (EPA). ACTION...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-27
... released, combusted, or oxidized, industrial gas suppliers, and manufacturers of heavy-duty and off-road... Submitted to OMB for Review and Approval; Comment Request; Greenhouse Gas Reporting Program (Renewal) AGENCY... submitted an information collection request (ICR), Greenhouse Gas Reporting Program (Renewal) (EPA ICR No...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-05
... Support of EPA's Third Six-Year Review of National Primary Drinking Water Regulations (Renewal); EPA ICR..., Office of Ground Water and Drinking Water, Standards and Risk Management Division (MC 4607M...: Contaminant Occurrence Data in Support of EPA's Third Six- Year Review of National Primary Drinking Water...
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EPA Facilities and Regional Boundaries Service, US, 2012, US EPA, SEGS
This SEGS web service contains EPA facilities, EPA facilities labels, small- and large-scale versions of EPA region boundaries, and EPA region boundaries extended to the 200nm Exclusive Economic Zone (EEZ). Small scale EPA boundaries and boundaries extended to the EEZ render at scales of less than 5 million, large scale EPA boundaries draw at scales greater than or equal to 5 million. EPA facilities labels draw at scales greater than 2 million. Data used to create this web service are available as a separate download at the Secondary Linkage listed above. Full FGDC metadata records for each layer may be found by clicking the layer name in the web service table of contents (available through the online link provided above) and viewing the layer description. This SEGS dataset was produced by EPA through the Office of Environmental Information.
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EPA GEOSPATIAL QUALITY COUNCIL
The EPA Geospatial Quality Council (previously known as the EPA GIS-QA Team - EPA/600/R-00/009 was created to fill the gap between the EPA Quality Assurance (QA) and Geospatial communities. All EPA Offices and Regions were invited to participate. Currently, the EPA Geospatial Q...
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Criteria For Evaluation of Proposed Protozoan Detection Methods
Currently, the only EPA approved method for detection and quantitation of protozoan cysts and oöcysts in source and drinking water, is the “ICR Protozoan Method for Detecting Giardia Cysts and Cryptosporidium Oöcysts in Water by a Fluorescent Antibody Procedure (ICR Microbial La...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-10
....regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or... , or in person at the Air and Radiation Docket in the EPA Docket Center (EPA/DC), EPA West, Room 3334...: This ICR will expire on 02/28/2013. An agency may not conduct or sponsor, and a person is not required...
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Calibration of marginal oscillator sensitivity for use in ICR spectrometry
NASA Technical Reports Server (NTRS)
Anicich, V. G.; Huntress, W. T., Jr.
1977-01-01
A constant-reference load is utilized as Q-spoiler in calibrations of relative sensitivity variations of a marginal oscillator with frequency. Frequency-dependent effects troublesome in earlier Q-spoilers are compensated by employing a pure resistive calibration load with compensation for the small distributed capacitance of large resistors. The validity of the approach is demonstrated for a 2:1 mass ratio range, and validity for a mass ratio range greater than 10:1 is claimed. The circuit and technique were developed for use in ion cyclotron resonance (ICR) spectrometric practice.
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Procedure: Ensuring EPA Public Content in the EPA Web Environment
This document outlines the procedures for ensuring access to EPA information by hosting EPA data and information on the epa.gov server. Additionally, it provides the procedures for obtaining waivers of this requirement.
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Conducting non-commercial international clinical trials: the ICR-CTSU experience.
Fox, Lisa; Toms, Christy; Kernaghan, Sarah; Snowdon, Claire; Bliss, Judith M
2017-09-26
Academic clinical trials play a fundamental role in the development of new treatments, the repurposing of existing treatments and in addressing areas of unmet clinical need. With cancer treatments increasingly targeted at molecular subtypes, and with priority placed on developing new treatments for rare tumour types, the need for international trial participation to access sufficient patient numbers for successful trial conduct is growing. However, lack of harmonisation of international legal, ethical and financial systems can make this challenging and the cost and effort of conducting trials internationally can be considered prohibitive, particularly where the sample size is comparatively small. The Institute of Cancer Research - Clinical Trials and Statistics Unit (ICR-CTSU) is a UK-based academic clinical trials unit that specialises in the design, conduct and analysis of clinical trials of cancer treatments with an expanding portfolio of trials in molecular subtypes of breast and urological cancers and in other rare cancer types. Implementing appropriate mechanisms to enable international participation has therefore been imperative. In this article, we explain how we have approached the challenges involved and describe examples of successful international trial conduct, achieved through robust collaborations with academic and industry partners. Conducting academic trials internationally is challenging but can and should be achieved through appropriate governance mechanisms and strong collaborations.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-14
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR affects diesel refiners, importers, and distributors.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-03
...The Environmental Protection Agency is planning to submit an information collection request (ICR), Recordkeeping and Reporting Requirements Regarding the Sulfur Content of Motor Vehicle Gasoline under the Tier 2 Rule, to the Office of Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act (PRA). Before doing so, EPA is soliciting public comments on specific aspects of the proposed information collection as described below. This is a proposed extension of the ICR, which is currently approved through January 31, 2013. An Agency may not conduct or sponsor and a person is not required to respond to a collection of information unless it displays a currently valid OMB control number.
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The EPA Recovery Mapper is an Internet interactive mapping application that allows users to discover information about every American Recovery and Reinvestment Act (ARRA) award that EPA has funded for six programs. By integrating data reported by the recipients of Recovery Act funding and data created by EPA, this application delivers a level of transparency and public accessibility to users interested in EPA's use of Recovery Act monies. The application is relatively easy to use and builds on the same mapping model as Google, Bing, MapQuest and other commonly used mapping interfaces. EPA Recovery Mapper tracks each award made by each program and gives basic Quick Facts information for each award including award name, location, award date, dollar amounts and more. Data Summaries for each EPA program or for each state are provided displaying dollars for Total Awarded, Total Received (Paid), and Total Jobs This Quarter by Recovery for the latest quarter of data released by Recovery.gov. The data are reported to the government and EPA four times a year by the award recipients. The latest quarterly report will always be displayed in the EPA Recovery Mapper. In addition, the application provides many details about each award. Users will learn more about how to access and interpret these data later in this document. Data shown in the EPA Recovery Mapper are derived from information reported back to FederalReporting.gov from the recipients of Recovery Act funding. EPA
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Index to Print Version of EPA Stylebook
This EPA Communication Product Standards index provides page numbers for topics such as Ampersands, Bitmapped Graphics, Exhibits and Displays, Podium Signage, Proofing, Sentence Length, Title Page, and Web Forms.
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76 FR 5800 - Agency Information Collection Activities: Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-02
....regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or... renew an existing approved Information Collection Request (ICR) 2258.02-- Implementation of the 1997 and...-566-1741 Mail: Attention Docket ID No. EPA-HQ-OAR-2007-0265, U.S. Environmental Protection Agency, EPA...
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The EPA OIG Hotline receives complaints of fraud, waste, and abuse in EPA programs and operations including mismanagement or violations of law, rules, or regulations by EPA employees or program participants.
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EPA Order 5700.7A1: EPA's Policy for Environmental Results under EPA Assistance Agreements
This order establishes Environmental Protection Agency (EPA) policy for addressing environmental results under EPA assistance agreements, including results that advance EPA’s environmental and human health mission.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-04
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0793; FRL-9527-3] Information Collection Request... Annual Measures Reporting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency has submitted an information collection request (ICR), ``Pesticide Environmental...
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Jin, J.M.; Kim, S.; Birdwell, J.E.
2011-01-01
Fourier transform ion cyclotron resonance mass spectrometry (FT ICR-MS) was applied in the analysis of shale oils generated using two different pyrolysis systems under laboratory conditions meant to simulate surface and in situ oil shale retorting. Significant variations were observed in the shale oils, particularly the degree of conjugation of the constituent molecules. Comparison of FT ICR-MS results to standard oil characterization methods (API gravity, SARA fractionation, gas chromatography-flame ionization detection) indicated correspondence between the average Double Bond Equivalence (DBE) and asphaltene content. The results show that, based on the average DBE values and DBE distributions of the shale oils examined, highly conjugated species are enriched in samples produced under low pressure, high temperature conditions and in the presence of water.
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The EPA eXcats is an enterprise-level data tracking application that provides management complaint tracking information for the EPA's Office of Civil Rights (OCR) External Compliance Program. EPA's OCR is responsible for enforcing several federal civil rights laws that together prohibit discrimination on the bases of race, color, national origin (including limited English proficiency), disability, sex and age in programs or activities that receive federal financial assistance from the EPA.
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Ding, Lin; Wang, Dan; Zhou, Miaomiao; Du, Lei; Xu, Jie; Xue, Changhu; Wang, Yuming
2016-07-01
Recent studies have shown that EPA enriched PLs have beneficial effects on lipid metabolism. Our previous study has demonstrated that the anti-obesity and hypolipidemic effects of EPA-PL were superior to DHA-PL. In the present study, we comparatively evaluated the effects of EPA-enriched phosphatidylcholine (EPA-PC) and EPA-enriched phosphatidylserine (EPA-PS) on lipid metabolism in mice. Both 2% dietary EPA-PC and EPA-PS significantly improved serum and hepatic lipid levels in mice. The HDL-c level in mice on EPA-PC diet was significantly higher than the other two groups. The level of DHA in hepatic TG and PL were significantly increased in both EPA-PC and EPA-PS fed groups (98.3 and 117.8%, respectively; p < 0.05). Notably, the proportion of DHA in EPA-PS group was significantly higher than the EPA-PC group. EPA-PC and EPA-PS suppressed hepatic SREBP-1c mediated lipogenesis and activated PPARα mediated fatty acid β-oxidation in the liver. These data are the first to indicate that EPA-PS has beneficial effects on lipid metabolism.
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Rezaei, Marzieh; Hosseini, Ahmad; Nikeghbalian, Saman; Ghaderi, Abbas
Basic research in the field of acinar cell carcinoma (ACC) as a rare neoplasm of the pancreas is dependent on the availability of pragmatic model such as new pancreatic cancer cell lines. Thus, establishment and characterization of new pancreatic cancer cell lines from ACC origin are deemed important. Faraz-ICR cell line was derived from a 58-years old woman with pancreatic acinar cell carcinoma by the collagenase digestion protocol. We characterized the cell line by examining its morphology and cytostructural and functional profile. Faraz-ICR has a doubling time of 35 hours and grows in soft agar with a colony-forming efficiency of 25%. The cell had nearly normal pattern of chromosomes in karyotype analysis and Comparative Genomic Hybridization (CGH) array analysis. Evaluation of cells by flowcytometry showed that Faraz-ICR is negative for EpCAM and mesenchymal markers in different passages, and has epithelial nature. Immunofluorescence staining revealed that cells were strongly positive for vimentin, desmin, ezrin, S100, nestin and they were negative for pan-cytokeratins, chromogranin and alpha smooth muscle actin. We were able to establish a new pancreatic carcinoma cell line with partial aspects of Epithelial-mesenchymal transition and aggressiveness. This cell line might be suitable for studying various anticancer drugs and protein profile aiming to see any possible tumor associated marker for ACC. Copyright © 2017 IAP and EPC. Published by Elsevier B.V. All rights reserved.
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40 CFR 80.1452 - What are the requirements related to the EPA Moderated Transaction System (EMTS)?
Code of Federal Regulations, 2011 CFR
2011-07-01
... importer. (2) The EPA company registration number of the renewable fuel or foreign ethanol producer, as... registration number of the renewable fuel or foreign ethanol producer, as applicable. (5) The importer's EPA...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-07
... information collection request (ICR), ``Participation by Disadvantaged Business Enterprises in Procurement... considered a Minority Business Enterprise (MBE) or Women's Business Enterprise (WBE) under EPA's Disadvantaged Business Enterprise (DBE) Program. EPA currently requires an entity to first attempt to become...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-23
... Emission Standards for Automobile Refinish Coatings (Renewal) AGENCY: Environmental Protection Agency (EPA... request (ICR), National Volatile Organic Compound Emission Standards for Automobile Refinish Coatings (EPA... schedule for their regulation (60 FR 15264). Automobile refinish coatings were included on the list, and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-23
... Internal Combustion Engines (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...), ``NESHAP for Stationary Reciprocating Internal Combustion Engines (Renewal)'' (EPA ICR No. 1975.09, OMB... combustion engines (RICE) have been regulated under previous actions. Thus, this final action fulfills the...
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FT-ICR mass spectrometric and density functional theory studies of sulfate prenucleation clusters
NASA Astrophysics Data System (ADS)
Lemke, K. H.
2012-12-01
Recent mass spectrometric1 and relaxation spectroscopic studies2 of metal sulfate salts have demonstrated that aqueous clusters play an important role in sulfate prenucleation processes. While such studies provide evidence that that ion clusters are nucleation relevant species, ultra-high resolution mass spectrumetry, in particular, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR/MS) can provide additional valuable information about the molecular composition and stability of individual ion clusters. Prompted by the above studies, our group has begun a systematic survey of metal sulfate clusters using FT-ICR mass spectrometry. Here, I report stoichiometries, structures and thermodynamic properties of calcium sulfate ion clusters, both "dry" and microsolvated, using electrospray ionization FT-ICR mass spectrometry in combination with semi-empirical methods and M062X/aug-cc-PVXZ level density functional theory calculations. In electrosprayed dilute aqueous solutions of CaSO4 (1-20mM), droplet desolvation results in the formation of stable doubly-charged clusters of [Ca(CaSO4)m(H2O)n]+2 (m≤10 & n≤9) as well as larger quadruply-charged ion clusters [Ca2(CaSO4)m(H2O)n]+4 with m≤23 and n≤10, demonstrating considerable sulfate nucleation potential in undersaturated electrolyte solutions. An attempt was also made to assess the extent of ion cluster aggregation in solution prior to electrospray ionization by measuring ion mass spectra at different solution concentrations. In brief, an increase in calcium sulfate concentration from 1-10mM results in a continuous increase in polynuclear ion cluster species, while smaller clusters, for instance, Ca[CaSO4]+2 and corresponding hydrated forms, become increasingly less abundant. Building on semi-empirical methods, M062X calculations have been applied to predict calcium sulfate cluster geometries, both "dry" and microsolvated, as well as the size-dependent evolution of clustering and hydration energies. 1
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-30
... Activities; Submission to OMB for Review and Approval; Comment Request; EPA's Design for the Environment (DfE... Budget (OMB) for review and approval: EPA's Design for the Environment (DfE) Partner of the Year Awards... . Title: EPA's Design for the Environment (DfE) Partner of the Year Awards Program. ICR Status: This is a...
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Bill would bolster science at EPA
NASA Astrophysics Data System (ADS)
Showstack, Randy
Since its establishment in 1970, the U.S. Environmental Protection Agency (EPA) has primarily served as a regulatory agency with a significant science component. However, the agency's scientific practices and performance at times have been criticized by the U.S. General Accounting Office, the National Academies of Science (NAS), Congress, and EPA's own science advisory board, as well as in a number of lawsuits.New legislation introduced by Rep. Vernon Ehlers (R-Mich.), chair of the House of Representatives' Science Subcommittee on Environment, Technology, and Standards, includes measures meant to improve the agency's science component. The legislation, H.R. 64, would require the president to appoint an EPA deputy administrator for science and technology This deputy administrator, who would rank higher than existing assistant administrators (AAs), would be responsible for the overall scientific and technical foundation of the agency's decisions, including ensuring that the agency's scientific endeavors use the best possible peer review and research planning practices.
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Benigni, Paolo; DeBord, J. Daniel; Thompson, Christopher J.; Gardinali, Piero; Fernandez-Lima, Francisco
2016-01-01
Thousands of chemically distinct compounds are encountered in fossil oil samples that require rapid screening and accurate identification. In the present paper, we show for the first time, the advantages of gas chromatography (GC) separation in combination with atmospheric-pressure laser ionization (APLI) and ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for the screening of polyaromatic hydrocarbons (PAHs) in fossil oils. In particular, reference standards of organics in shale oil, petroleum crude oil, and heavy sweet crude oil were characterized by GC-APLI-FT-ICR MS and APLI-FT-ICR MS. Results showed that, while APLI increases the ionization efficiency of PAHs, when compared to other ionization sources, the complexity of the fossil oils reduces the probability of ionizing lower-concentration compounds during direct infusion. When gas chromatography precedes APLI-FT-ICR MS, an increase (more than 2-fold) in the ionization efficiency and an increase in the signal-to-noise ratio of lower-concentration fractions are observed, giving better molecular coverage in the m/z 100–450 range. That is, the use of GC prior to APLI-FT-ICR MS resulted in higher molecular coverage, higher sensitivity, and the ability to separate and characterize molecular isomers, while maintaining the ultrahigh resolution and mass accuracy of the FT-ICR MS separation. PMID:27212790
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-31
.../ Institutional Steam Generating Units (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... that an Information Collection Request (ICR) has been forwarded to the Office of Management and Budget... Information and Regulatory Affairs, Office of Management and Budget (OMB), Attention: Desk Officer for EPA...
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77 FR 39699 - Agency Information Collection Activities; Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-05
... Budget (OMB). Before submitting the ICR, titled: ``Soil Fumigant Risk Mitigation'' and identified by EPA..., soil fumigant registrants, state and tribal lead agencies, and EPA. Title: Soil Fumigant Risk... ensure that risk mitigation measures necessary for reregistration eligibility for certain soil fumigant...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-29
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2009-0494; FRL-9108-2] Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request; Tips and Complaints Regarding Environmental Violations; EPA ICR No. 2219.03, OMB Control No. 2020- 0032 AGENCY: Environmental Protection...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-16
... Waste Incinerators (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2012-0502; FRL-9526-3] Agency Information Collection... Information Collection Request (ICR) has been forwarded to the Office of Management and Budget (OMB) for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-15
... fuel or additive, and certain technical, marketing, and health-effects information. The development of... Request; Comment Request; Registration of Fuels and Fuel Additives--Requirements for Manufacturers; EPA... Fuels and Fuel Additives--Requirements for Manufacturers'' (EPA ICR No. 0309.14, OMB Control No. 2060...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-10
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2011-0424; FRL 9510-3] Agency Information Collection... Management Resource Analysis (New) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In... Information Collection Request (ICR) has been forwarded to the Office of Management and Budget (OMB) for...
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FT-ICR MS analysis of blended pine-microalgae feedstock HTL biocrudes
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jarvis, Jacqueline M.; Billing, Justin M.; Corilo, Yuri E.
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) is utilized for direct comparison of the chemical composition of biocrudes generated from the hydrothermal liquefaction of 100% pine, 100% algae, 75:25 pine:algae, and 50:50 pine:algae feedstocks. This analysis reveals that the of the 72:25 and 50:50 pine:algal HTL biocrudes is essentially a composite of the two parent feeds (i.e., pine and algae) with a lower relative abundance of Ox species and a higher relative abundance of nitrogen-containing species than the pine HTL biocrude. Alternatively, the biocrude blends have a lower relative abundance of nitrogen-containing species where N>2 than the algalmore » HTL biocrude. The 75:25 pine:algal HTL biocrude has more elemental formulae in common with the pine HTL biocrude than the 50:50 blend; however, both blends have more elemental formulae in common with the algal HTL biocrude. Interestingly, >20% of the elemental formulae assigned to monoisotopic peaks within the 75:25 and 50:50 biocrude blends are species not present in either the pine or algal HTL biocrudes. The highest relative abundance of these new species belong to the N2O4-6 classes, which correspond to heteroatom classes with a moderate number of nitrogen atoms and higher number of oxygen atoms per molecules than the species within the pure algal HTL biocrude. Compositionally, the novel species have the same structural motif but are of higher DBE and carbon numbers than the species within the algal HTL biocrude. These original species are most likely generated from reactions between molecules from both feeds, which results in compounds wotj higher oxygen content than typically seen in the algal HTL biocrude but also higher nitrogen contents than observed in the pine HTL biocrude.« less
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-01-19
... DEPARTMENT OF LABOR Proposed Information Collection Request (ICR) for the Mining Voice in the...)(A)]. This program helps to ensure that required data can be provided in the desired format...' voice in mining workplaces under the jurisdiction of DOL's Mine Safety and Health Administration (MSHA...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-02
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an existing approved Information Collection Request (ICR) to the Office of Management and Budget (OMB). This request is to renew an ICR that will expire on July 31, 2010.
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EPA Facilities and Regional Boundaries Download Package, US, 2012, US EPA, SEGS
This downloadable package contains the following layers: EPA facility points, EPA region boundary polygons and EPA region boundary polygons extended to the 200nm Exclusive Economic Zone (EEZ). Included in this package are a file geodatabase (v. 10.0), Esri ArcMap map document (v. 10.0) and XML files for this record and the layer level metadata. This SEGS dataset was produced by EPA Office of Environmental Information (OEI).
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Kim, H J; Kim, D K; Kim, H; Koh, J Y; Kim, K M; Noh, M S; Lee, S; Kim, S; Park, S H; Kim, J J; Kim, S Y; Lee, C H
2008-01-01
Background and purpose: Recently, we reported that 12(S)-HPETE (12(S)-hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid) induces scratching in ICR mice. We hypothesized that 12(S)-HPETE might act as an agonist of the low-affinity leukotriene B4 receptor BLT2. To confirm the involvement of the BLT2 receptor in 12(S)-HPETE-induced scratching, we studied the scratch response using the BLT2 receptor agonists compound A (4′-{[pentanoyl (phenyl) amino]methyl}-1,1′-biphenyl-2-carboxylic acid) and 12(S)-HETE (12(S)-hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid). Experimental approach: A video recording was used to determine whether the BLT2 receptor agonists caused itch-associated scratching in ICR mice. Selective antagonists and several chemicals were used. Key results: Both 12(S)-HETE and compound A dose dependently induced scratching in the ICR mice. The dose–response curve for compound A showed peaks at around 0.005–0.015 nmol per site. Compound A- and 12(S)-HETE-induced scratching was suppressed by capsaicin and naltrexon. We examined the suppressive effects of U75302 (6-[6-(3-hydroxy-1E,5Z-undecadienyl)-2-pyridinyl]-1,5-hexanediol, the BLT1 receptor antagonist) and LY255283 (1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone, the BLT2 receptor antagonist) on the BLT2 agonist-induced scratching. LY255283 suppressed compound A- and 12(S)-HETE-induced scratching, but U75302 did not. LY255283 required a higher dose to suppress the compound A-induced scratching than it did to suppress the 12(S)-HETE-induced scratching. One of the BLT2 receptor agonists, 12(R)-HETE (12(R)-hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid), also induced scratching in the ICR mice. Conclusions and implications: Our present results corroborate the hypothesis that the BLT2 receptor is involved in 12(S)-lipoxygenase-product-induced scratching in ICR mice. We also confirmed that this animal model could be a valuable means of evaluating the effects of BLT2 receptor
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-31
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OA-2006-0278; FRL-9669-9] Agency Information Collection... submit a request to reinstate an Information Collection Request (ICR) to the Office of Management and... approval, EPA is soliciting comments on specific aspects of the proposed information collection as...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-05
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPA-2007-0584; FRL-9530-1] Information Collection Request Submitted to OMB for Review and Approval; Comment Request; Spill Prevention, Control and Countermeasure..., Control and Countermeasures (SPCC) Plans (Renewal)'' (EPA ICR No. 0328.16, OMB Control No. 2050-0021) to...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-13
... Rework Facilities (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The... Manufacturing and Rework Facilities (40 CFR Part 63, Subpart GG) (Renewal)'' (EPA ICR No. 1687.09, OMB Control... are owners or operators of aerospace manufacturing and rework operations. Respondents must submit one...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-04
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2009-0536; FRL-9100-2] Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment Request; Emission Guidelines and Compliance Times for Municipal Solid Waste Landfills (Renewal); EPA ICR No. 1893.05, OMB Control No. 2060-0430...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-29
... Office of Management and Budget; OMB Control Numbers: 1625-0058, 1625-0072 and 1625-0092 AGENCY: Coast..., and 1625-0092 Sewage and Graywater Discharge Records for Certain Cruise Vessels Operating on Alaskan... OMB Control Number of the ICR and the docket number of this request, [USCG-2010-1137], and must be...
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EPA's Web Taxonomy is a faceted hierarchical vocabulary used to tag web pages with terms from a controlled vocabulary. Tagging enables search and discovery of EPA's Web based information assests. EPA's Web Taxonomy is being provided in Simple Knowledge Organization System (SKOS) format. SKOS is a standard for sharing and linking knowledge organization systems that promises to make Federal terminology resources more interoperable.
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USE OF QSPRS IN IMPROVING CARBON ADSORPTION MODELING OF EPA CONTAMINANT CANDIDATE COMPOUNDS
Activated carbon adsorption of EPA contaminant candidate list (CCL) compounds is under investigation as a treatment technology for contaminated drinking water. Historically, EPA, in support of drinking water regulations, has used a number of techniques to calculate field-scale c...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-11
... characteristics? What are YouthBuild's impacts on crime and delinquency? What are the program's impacts on social... (ICR) for the Impact Evaluation of the YouthBuild Program; Comment Request AGENCY: Employment and..., collection instruments are clearly understood, and [[Page 27364
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EPA Grants 101 Tutorial teaches you how to apply for , manage, and complete an EPA Grant with this easy-to-follow flowchart. This tutorial is extremely benefical for those seeking EPA Grant knowledge.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-03
... Review by Office of Management and Budget: OMB Control Numbers: 1625-0058, 1625-0072 and 1625-0092 AGENCY... Recordkeeping, and 1625-0092 Sewage and Graywater Discharge Records for Certain Cruise Vessels Operating on... contain the OMB Control Number of the ICR. They must also contain the docket number of this request, [USCG...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-31
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2004-0077; FRL-9259-4] Agency Information Collection Activities; Proposed Collection; Comment Request; Significant New Alternatives Policy (SNAP) Program Final Rulemaking Under Title VI of the Clean Air Act Amendments of 1990; EPA ICR No. 1596.08, OMB Control No. 2060...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-20
... Alternative Fuels Conversions AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The... Emissions: Revisions to Certification of Alternative Fuels Conversions'' (EPA ICR No. 0783.64, OMB Control... Vehicle and Engine Conversions Final Rule which was issued on April 8, 2011 (76 FR 19830). This includes a...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-10
... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-SFUND-2006-0361; FRL-9522-6] Information Collection Request Submitted to OMB for Review and Approval; Comment Request; Trade Secret Claims for Emergency...), ``Trade Secret Claims for Emergency Planning and Community Right-to-Know Act'' (EPA ICR No. 1428.09, OMB...
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Kill, Jade B; Oliveira, Izabela F; Tose, Lilian V; Costa, Helber B; Kuster, Ricardo M; Machado, Leandro F; Correia, Radigya M; Rodrigues, Rayza R T; Vasconcellos, Géssica A; Vaz, Boniek G; Romão, Wanderson
2016-09-01
The synthetic cannabinoids (SCs) represent the most recent advent of the new psychotropic substances (NPS) and has become popularly known to mitigate the effects of the Δ(9)-THC. The SCs are dissolved in organic solvents and sprayed in a dry herbal blend. However, little information is reported on active ingredients of SCs as well as the excipients or diluents added to the herbal blend. In this work, the direct infusion electrospray ionization Fourier transform ion cyclotron mass spectrometry technique (ESI-FT-ICR MS) was applied to explore the chemical composition of nine samples of herbal extract blends, where a total of 11 SCs (UR-144, JWH-073, XLR-11, JWH-250, JWH-122, AM-2201, AKB48, JWH-210, JWH-081, MAM-2201 and 5F-AKB48) were identified in the positive ionization mode, ESI(+), and other 44 chemical species (saturated and unsaturated fatty acids, sugars, flavonoids, etc.) were detected in the negative ionization mode, ESI(-). Additionally, CID experiments were performed, and fragmentation pathways were proposed to identify the connectivity of SCs. Thus, the direct infusion ESI-FT-ICR MS technique is a powerful tool in forensic chemistry that enables the rapid and unequivocal way for the determination of molecular formula, the degree of unsaturation (DBE-double bond equivalent) and exact mass (<1ppm) of a total of 55 chemical species without the prior separation step. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
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Azumah, Bright K.; Addo, Phyllis G.; Dodoo, Alfred; Awandare, Gordon; Mosi, Lydia; Boakye, Daniel A.
2017-01-01
The transmission of Buruli ulcer (BU), caused by Mycobacterium ulcerans (MU), remains puzzling although a number of hypothesis including through bites of infected aquatic insects have been proposed. We report the results of experiments using ICR mice that give credence to our hypothesis that Acanthamoeba species may play a role in BU transmission. We cocultured MU N2 and MU 1615 which expresses red fluorescent protein (RFP) and Acanthamoeba polyphaga (AP), and confirmed infected AP by Ziehl-Neelsen (ZN) staining. We tested for viability of MU inside AP and observed strong RFP signals inside both trophozoites and cysts after 3 and 42 days of coculturing respectively. ICR mice were topically treated, either on shaved intact or shaved pinpricked rumps, with one of the following; MU N2 only (2.25 x 106 colony forming units [CFU] / ml), MU N2:AP coculture (2.96 x 104 CFU: 1.6 x 106 cells/ml), AP only (1.6 x 106 cells/ml), PYG medium and sterile distilled water. Both MU N2 only and MU N2:AP elicited reddening on day (D) 31; edema on D 45 and D 44 respectively, and ulcers on D 49 at pinpricked sites only. To ascertain infectivity and pathogenicity of MU N2 only and MU N2:AP, and compare their virulence, the standard mouse footpad inoculation method was used. MU N2:AP elicited reddening in footpads by D 3 compared to D 14 with MU N2 only of the same dose of MU N2 (2.96 x 104 CFU). ZN-stained MU were observed in both thin sectioned and homogenized lesions, and aspirates from infected sites. Viable MU N2 were recovered from cultures of the homogenates and aspirates. This study demonstrates in ICR mice MU transmission via passive infection, and shows that punctures in the skin are prerequisite for infection, and that coculturing of MU with AP enhances pathogenesis. PMID:28329001
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Implementing EPA Method 537 | Science Inventory | US EPA
This presentation describes EPA Method 537 for the analysis of 14 perfluorinated alkyl acids in drinking water as well as the challenges associated with preparing a laboratory for analysis using Method 537. The impact of this presentation is to provide the scientific community with an introduction to EPA Method 537 and to provide suggestions on implementing this method in laboratories.
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Mahamdallie, Shazia; Ruark, Elise; Yost, Shawn; Ramsay, Emma; Uddin, Imran; Wylie, Harriett; Elliott, Anna; Strydom, Ann; Renwick, Anthony; Seal, Sheila; Rahman, Nazneen
2017-01-01
Detection of deletions and duplications of whole exons (exon CNVs) is a key requirement of genetic testing. Accurate detection of this variant type has proved very challenging in targeted next-generation sequencing (NGS) data, particularly if only a single exon is involved. Many different NGS exon CNV calling methods have been developed over the last five years. Such methods are usually evaluated using simulated and/or in-house data due to a lack of publicly-available datasets with orthogonally generated results. This hinders tool comparisons, transparency and reproducibility. To provide a community resource for assessment of exon CNV calling methods in targeted NGS data, we here present the ICR96 exon CNV validation series. The dataset includes high-quality sequencing data from a targeted NGS assay (the TruSight Cancer Panel) together with Multiplex Ligation-dependent Probe Amplification (MLPA) results for 96 independent samples. 66 samples contain at least one validated exon CNV and 30 samples have validated negative results for exon CNVs in 26 genes. The dataset includes 46 exon CNVs in BRCA1 , BRCA2 , TP53 , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM or PTEN , giving excellent representation of the cancer predisposition genes most frequently tested in clinical practice. Moreover, the validated exon CNVs include 25 single exon CNVs, the most difficult type of exon CNV to detect. The FASTQ files for the ICR96 exon CNV validation series can be accessed through the European-Genome phenome Archive (EGA) under the accession number EGAS00001002428.
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EPA Communications Stylebook: Basic Checklist for Product Development
Determine your top messages, check if a similar EPA product already exists, identify your target audience, develop a distribution plan, estimate cost, submit for PROTRAC review, use the Stylebook, get a publication number, final review, publish.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-08
... job characteristics? What are YouthBuild's impacts on crime and delinquency? What are the program's... (ICR) for the Impact Evaluation of the YouthBuild Program; New Collection AGENCY: Employment and... instruments are clearly understood, and the impact of collection requirements on respondents can be properly...
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76 FR 9988 - Improving EPA Regulations
Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-23
...., Washington, DC. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is (202) 566-1744, and the telephone... key considerations in mind: EPA must uphold its mission to protect human health and the environment...
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Circadian egg production by Echinostoma caproni (Digenea: Echinostomatidae) in ICR mice.
Platt, Thomas R; Hussey, Gabrielle L; Zelmer, Derek A
2013-04-01
Circadian egg production by Echinostoma caproni was investigated in ICR mice. Four female mice were infected with 25 E. caproni metacercariae, maintained in individual cages on a 12:12 light:dark cycle, and provided food and water ad libitum. Twenty-eight, 51, and 58 days post-infection, mice were transferred to individual, wire-bottomed cages and feces were collected every 2 hr for 24 hr. The feces were weighed and processed immediately to estimate the number of eggs present. Fecal output and egg production were standardized to unit maxima for analysis. Standardized egg count and standardized fecal output followed distinctly circadian patterns and covaried. Egg production was highest from 2200 to 0200 hr and lowest from 1000 to 1800 hr. These correspond to the highest and lowest fecal production, and highest and lowest periods of host activity, respectively. Egg density (eggs/g of feces) covaried weakly with fecal output with an additional peak at 0800-1000 hr, suggesting E. caproni is responding to changes in host physiology in timing of the production and release of eggs into the intestine. The continuous production and release of eggs during the patent period, coupled with the circadian pattern of daily egg release by E. caproni , would result in the widest dispersal of eggs in the host environment and enhance transmission to the first intermediate host.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-24
... Office of Management and Budget; OMB Control Number: 1625-0106 AGENCY: Coast Guard, DHS. ACTION: Sixty....S. Coast Guard intends to submit an Information Collection Request (ICR) to the Office of Management... Coast Guard docket number [USCG-2011-0087] to the Docket Management Facility (DMF) at the U.S...
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Probing the Mechanisms of an Air Amplifier using a LTQ-FT-ICR-MS and Fluorescence Spectroscopy
Dixon, R. Brent; Muddiman, David C.; Hawkridge, Adam M.; Fedorov, A. G.
2008-01-01
We report the first quantitative assessment of electrosprayed droplet/ion focusing enabled by the use of a voltage-assisted air amplifier between an electrospray ionization emitter and a hybrid linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (ESI-LTQ-FT-ICR-MS). A solution of fluorescent dye was electrosprayed with a stainless steel mesh screen placed in front of the MS inlet capillary acting as a gas-permeable imaging plate for fluorescence spectroscopy. Without use of the air amplifier no detectable FT-ICR signal was observed, as well as no detectable fluorescence on the screen upon imaging using a fluorescence scanner. When the air amplifier was turned ON while electrospraying the fluorescent dye, FT-ICR mass spectra with high signal to noise ratio were obtained with an average ion injection time of 21 milliseconds for an AGC target value of 5 × 105. Imaging of the screen using a fluorescence scanner produced a distinct spot of cross-sectional area ~33.5 mm2 in front of the MS inlet capillary. These experimental results provide direct evidence of aerodynamic focusing of electrosprayed droplets/ions enabled by an air amplifier, resulting in improved electrospray droplet/ion capture efficiency and reduced ion injection time. A second set of experiments was carried out to explore whether the air amplifier assists in desolvation. By electrospraying a mix of quaternary amines, ratios of increasingly hydrophobic molecules were obtained. Observation of the solvophobic effect associated with electrospray ionization resulted in a higher abundance of the hydrophobic molecule. This bias was eliminated when the air amplifier was turned ON and a response indicative of the respective component concentrations of the molecules in the bulk solution was observed. PMID:17855111
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NASA Astrophysics Data System (ADS)
Shah, Shahid Ali; Yoon, Gwang Ho; Ahmad, Ashfaq; Ullah, Faheem; Amin, Faiz Ul; Kim, Myeong Ok
2015-09-01
The adverse effects of nanoscale-alumina (Al2O3-NPs) have been previously demonstrated in both in vitro and in vivo studies, whereas little is known about their mechanism of neurotoxicity. It is the goal of this research to determine the toxic effects of nano-alumina on human neuroblastoma SH-SY5Y and mouse hippocampal HT22 cells in vitro and on ICR female mice in vivo. Nano-alumina displayed toxic effects on SH-SY5Y cell lines in three different concentrations also increased aluminium abundance and induced oxidative stress in HT22 cells. Nano-alumina peripherally administered to ICR female mice for three weeks increased brain aluminium and ROS production, disturbing brain energy homeostasis, and led to the impairment of hippocampus-dependent memory. Most importantly, these nano-particles induced Alzheimer disease (AD) neuropathology by enhancing the amyloidogenic pathway of Amyloid Beta (Aβ) production, aggregation and implied the progression of neurodegeneration in the cortex and hippocampus of these mice. In conclusion, these data demonstrate that nano-alumina is toxic to both cells and female mice and that prolonged exposure may heighten the chances of developing a neurodegenerative disease, such as AD.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-20
... Environmental Research Involving Human Subjects; EPA ICR No. 2195.04, OMB Control No. 2070-0169. This is a...-OPP- 2011-0704, to (1) EPA online using http://www.regulations.gov (our preferred method), or by mail..., Confidential Business Information (CBI), or other information whose public disclosure is restricted by statute...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-29
... programs) (444220 Retail Nursery, Lawn, and Garden Supply stores, 424910 Agricultural chemicals merchant...- 2010-0723, to (1) EPA online using http://www.regulations.gov (our preferred method), or by mail to... this ICR under Docket ID No. EPA-HQ-OPP-2010-0723, which is available for online viewing at http//: www...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-12
... time to allow EPA to finish working to restructure the ICR, improve the electronic forms and... effects'' on humans or to the environment. Under the Federal Food, Drug, and Cosmetic Act (FFDCA), EPA... in food and feed will be safe for human consumption, defined as ``a reasonable certainty that no harm...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-15
... Analysis Information Under Section 112(r)(7)(H) of the Clean Air Act (CAA) (Renewal); EPA ICR No. 1981.04... . Title: Distribution of Offsite Consequence Analysis Information under Section 112(r)(7)(H) of the Clean... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2003-0073; FRL-9103-6] Agency Information Collection...
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Electrostatic Plasma Accelerator (EPA)
NASA Technical Reports Server (NTRS)
Brophy, John R.; Aston, Graeme
1989-01-01
The Electrostatic Plasma Accelerator (EPA) is a thruster concept which promises specific impulse levels between low power arcjets and those of the ion engine while retaining the relative simplicity of the arcjet. The EPA thruster produces thrust through the electrostatic acceleration of a moderately dense plasma. No accelerating electrodes are used and the specific impulse is a direct function of the applied discharge voltage and the propellant atomic mass. The goal of the present program is to demonstrate feasibility of the EPA thruster concept through experimental and theoretical investigations of the EPA acceleration mechanism and discharge chamber performance. Experimental investigations will include operating the test bed ion (TBI) engine as an EPA thruster and parametrically varying the thruster geometry and operating conditions to quantify the electrostatic plasma acceleration effect. The theoretical investigations will include the development of a discharge chamber model which describes the relationships between the engine size, plasma properties, and overall performance. For the EPA thruster to be a viable propulsion concept, overall thruster efficiencies approaching 30% with specific impulses approaching 1000 s must be achieved.
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An entrustable professional activity (EPA) for handoffs as a model for EPA assessment development.
Aylward, Michael; Nixon, James; Gladding, Sophia
2014-10-01
Medical education is moving toward assessment of educational outcomes rather than educational processes. The American Board of Internal Medicine and American Board of Pediatrics milestones and the concept of entrustable professional activities (EPA)--skills essential to the practice of medicine that educators progressively entrust learners to perform--provide new approaches to assessing outcomes. Although some defined EPAs exist for internal medicine and pediatrics, the continued development and implementation of EPAs remains challenging. As residency programs are expected to begin reporting milestone-based performance, however, they will need examples of how to overcome these challenges. The authors describe a model for the development and implementation of an EPA using the resident handoff as an example. The model includes nine steps: selecting the EPA, determining where skills are practiced and assessed, addressing barriers to assessment, determining components of the EPA, determining needed assessment tools, developing new assessments if needed, determining criteria for advancement through entrustment levels, mapping milestones to the EPA, and faculty development. Following implementation, 78% of interns at the University of Minnesota Medical School were observed giving handoffs and provided feedback. The authors suggest that this model of EPA development--which includes engaging stakeholders, an iterative process to describing the behavioral characteristics of each domain at each level of entrustment, and the development of specific assessment tools that support both formative feedback and summative decisions about entrustment--can serve as a model for EPA development for other clinical skills and specialty areas.
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EPA Library Network Communication Strategies
To establish Agency-wide procedures for the EPA National Library Network libraries to communicate, using a range of established mechanisms, with other EPA libraries, EPA staff, organizations and the public.
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Usage of FT-ICR-MS Metabolomics for Characterizing the Chemical Signatures of Barrel-Aged Whisky
Roullier-Gall, Chloé; Signoret, Julie; Hemmler, Daniel; Witting, Michael A.; Kanawati, Basem; Schäfer, Bernhard; Gougeon, Régis D.; Schmitt-Kopplin, Philippe
2018-01-01
Whisky can be described as a complex matrix integrating the chemical history from the fermented cereals, the wooden barrels, the specific distillery processes, aging, and environmental factors. In this study, using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), we analyzed 150 whisky samples from 49 different distilleries, 7 countries, and ranging from 1 day new make spirit to 43 years of maturation with different types of barrel. Chemometrics revealed the unexpected impact of the wood history on the distillate's composition during barrel aging, regardless of the whisky origin. Flavonols, oligolignols, and fatty acids are examples of important chemical signatures for Bourbon casks, whereas a high number of polyphenol glycosides, including for instance quercetin-glucuronide or myricetin-glucoside as potential candidates, and carbohydrates would discriminate Sherry casks. However, the comparison of barrel aged rums and whiskies revealed specific signatures, highlighting the importance of the initial composition of the distillate and the distillery processes. PMID:29520358
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Usage of FT-ICR-MS Metabolomics for characterizing the chemical signatures of barrel-aged whisky
NASA Astrophysics Data System (ADS)
Roullier-Gall, Chloé; Signoret, Julie; Hemmler, Daniel; Witting, Michael A.; Kanawati, Basem; Schäfer, Bernhard; Gougeon, Régis D.; Schmitt-Kopplin, Philippe
2018-02-01
Whisky can be described as a complex matrix integrating the chemical history from the fermented cereals, the wooden barrels, the specific distillery processes, ageing and environmental factors. In this study, using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), we analysed 150 whisky samples from 49 different distilleries, 7 countries, and ranging from 1 day new make spirit to 43 years of maturation with different types of barrel. Chemometrics revealed the unexpected impact of the wood history on the distillatés composition during barrel ageing, regardless of the whisky origin. Flavonols, oligolignols and fatty acids are examples of important chemical signatures for Bourbon casks, whereas a high number of polyphenol glycosides, including for instance quercetin-glucuronide or myricetin-glucoside as potential candidates, and carbohydrates would discriminate Sherry casks. However, the comparison of barrel aged rums and whiskies revealed specific signatures, highlighting the importance of the initial composition of the distillate and the distillery processes.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-12
... with the Paperwork Reduction Act (44 U.S.C. 3501 et seq.). Before doing so, EPA is soliciting public... received will be included in the public docket without change including any personal information provided... the EPA will be collecting are available in the public docket for this ICR. The docket can be viewed...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-12
... comments, referencing Docket ID No. EPA-HQ-OAR- 2003-0162, to (1) EPA online using www.regulations.gov (our... collecting, are available in the public docket for this ICR. The docket can be viewed online at www... actions conform with the SIP requirements. Depending on the type of action, the federal entities must...
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Diurnal migration of Echinostoma caproni (Digenea: Echinostomatidae) in ICR mice.
Platt, Thomas R; Graf, Emily; Kammrath, Anna; Zelmer, Derek A
2010-12-01
Twenty-four female ICR mice, 12 acclimated to a 12 ∶ 12 light-dark cycle and 12 to a 12 ∶ 12 dark-light cycle for 7 days, were each infected with 10 metacercariae of Echinostoma caproni. Infected mice were maintained on their respective lighting regimes for 28 days. Six mice (3 from each group) were necropsied at 4-hr intervals beginning at 0700 hr. The small intestine was removed, opened, and the position of individual worms and worm clusters was measured to the nearest 0.1 cm. Each intestine was subsequently divided into 20 equal segments and individual worms and worm clusters were assigned to the appropriate segment based on the original measurements. All worms were found in the posterior 55% of the intestine (ileum). All posterior segments (10-20), with the exception of segment 18, harbored at least 1 worm at some time. A Monte Carlo simulation of worm abundance in segments 10-17 over all time periods indicated a random distribution, while the same analysis of segments 10-20 indicated a non-random distribution due to large numbers of worms in segment 20 and to the absence of worms in segment 18. To analyze temporal changes in worm distribution, mice were grouped by time of necropsy as follows: night (1900 and 2300 hr), morning (0300 and 0700 hr), and day (1100 and 1500 hr). During the night and morning, E. caproni was heavily concentrated in segments 10-17 and, during the day, worms were located more posteriorly, with a heavy concentration in the last segment (20).
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The article discusses air pollution research at the U.S. EPA, and particularly AEERL's role in that research which, in some areas, predates the Agency's. EPA's engineering research programs are shifting from an initial focus on sulfur dioxide and nitrogen oxide pollution control ...
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This booklet is designed to help you determine if you are subject to requirements under the Resource Conservation and Recovery Act (RCRA) for notifying the U.S. Environmental Protection Agency (EPA) of your regulated waste activities.
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Mischoulon, David; Papakostas, George I.; Dording, Christina M.; Farabaugh, Amy H.; Sonawalla, Shamsah B.; Agoston, Monica; Smith, Juliana; Beaumont, Erin; Dahan, Liat; Alpert, Jonathan E.; Nierenberg, Andrew A.; Fava, Maurizio
2010-01-01
Objective We examined the efficacy and tolerability of ethyl-eicosapentaenoate (EPA-E) monotherapy for major depressive disorder (MDD) in a double-blind, randomized controlled pilot study. Methods 57 adults with DSM-IV MDD were randomized from 1/2003-6/2006 to receive 1 gram/day of EPA or placebo (PBO) for 8 weeks. Response criteria were based on the Hamilton-D-17 scale. Subjects' plasma lipid profiles were examined by gas chromatography. Results 35 subjects (63% female; mean age 45+/-13 yrs) were eligible for the intent to treat (ITT) analysis. In the ITT sample, mean HAM-D-17 scores decreased from 21.6+/-2.7 to 13.9+/-8.9 for the EPA group (n=16) and from 20.5+/-3.6 to 17.5+/-7.5 for the PBO group (n=19) (p=0.123); the effect size for EPA was 0.55. ITT response rates were 38% (6/16) for EPA, and 21% (4/19) for PBO (p=0.45). Among the 24 study completers, mean HAM-D-17 scores decreased from 21.3+/-3.0 to 11.1+/-8.1 for the EPA group and from 20.5+/-3.8 to 16.3+/-6.9 for the PBO group (p=0.087); the effect size for EPA was 0.73. Completer response rates were 45% (5/11) for EPA, and 23% (3/13) for PBO (p=0.39). Among EPA subjects, baseline n-6/n-3 ratio was associated with decrease in HAM-D-17 score (r= -0.686, p=0.030) and with treatment response (p=0.032); change in n-6/n-3 ratio was associated with change in HAM-D-17 score (r=0.784, p=0.032). Side effects, reported in 2 EPA subjects and 5 PBO subjects, were exclusively gastrointestinal, mild, and not associated with discontinuation. Conclusions EPA demonstrated an advantage over placebo that did not reach statistical significance, possibly due to the small sample and low completer rates, which were the major study limitations. PMID:19709502
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EPA for Businesses and Non-Profits
Information and links to EPA web pages that are meant to help businesses and non-profits adhere to EPA regulations and otherwise protect the environment, take advantage of opportunities to collaborate with the EPA, and find training EPA training programs.
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NASA Astrophysics Data System (ADS)
Cooper, W. T.; Podgorski, D. C.; Osborne, D. M.; Corbett, J.; Chanton, J.
2010-12-01
Dissolved organic nitrogen is an often overlooked but potentially significant bioavailable component of dissolved organic matter. Studies of bulk DON turnover have been reported, but the compositions of the reactive and refractory components of DON are largely unknown. Here we show the unique ability of atmospheric pressure photoionization (APPI) coupled to ultrahigh resolution mass spectrometry to identify the reactive and refractory components of DON. Figure 1 is an isolated 0.30 m/z window from an ultrahigh resolution APPI FT-ICR mass spectrum of DON in surface waters draining an agricultural area in South Florida. Using this optimized, negative-ion APPI strategy we have been able to identify the reactive and refractory components of DON in these nitrogen-rich waters. Similar results were observed with samples from soil porewaters in sedge-dominated fens and sphagnum-dominated bogs within the Glacial Lake Agassiz Peatlands (GLAP) of northern Minnesota. Surprisingly, microbes appear to initially use similar enzymatic pathways to degrade DON and DOC, often with little release of nitrogen. Figure 1. Isolated 0.30 m/z window at nominal mass 432 from negative-ion APPI FT-ICR mass spectrum of DOM from waters draining an agricultural area in South Florida. Peaks marked contain nitrogen.
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Leclair, Jeffrey P; Collett, Jeffrey L; Mazzoleni, Lynn R
2012-04-17
Isolated water-soluble atmospheric organic matter (AOM) analytes extracted from radiation fogwater samples were analyzed using collision induced dissociation with ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Tandem mass analysis was performed on several mass ranges between 100 and 400 Da to characterize the functional groups of AOM species. Compounds containing nitrogen and/or sulfur were targeted because of the high number of oxygen atoms contained in their molecular formulas. Due to the large number of isobaric ions in the precursor isolation ranges, large numbers of product ions resulted from collision induced dissociation. Common neutral losses were assigned by matching the molecular formulas of the expected product ions with the detected product ions within the appropriate mass spectra. Since polar functional groups are expected to affect the hygroscopic properties of aerosols, the losses of H(2)O, CO(2), CH(3)OH, HNO(3), CH(3)NO(3), SO(3), SO(4) and combinations of these were specifically targeted. Among the 421 compounds studied, the most frequently observed neutral losses were CO(2) (54%), H(2)O (43%) and CH(3)OH (40%). HNO(3) losses were observed for 63% of the studied nitrogen containing compounds and 33% of the studied compounds containing both nitrogen and sulfur. SO(3) losses were observed for 85% of the studied sulfur containing compounds and 42% of studied compounds containing both nitrogen and sulfur. A number of molecular formulas matching those of monoterpene ozonolysis SOA were observed; they include organonitrates, organosulfates, and nitroxy-organosulfates. Overall, the results of fragmentation analysis of 400+ individual molecular precursors elucidate the complexity and multifunctional nature of the isolated water-soluble AOM.
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Biological activity of the azlactone derivative EPA-35 against Trypanosoma cruzi.
de Azeredo, Camila Maria Oliveira; Ávila, Eloah Pereira; Pinheiro, Danielle Lobo Justo; Amarante, Giovanni Wilson; Soares, Maurilio José
2017-02-01
Chagas disease, caused by Trypanosoma cruzi, affects six to seven million people worldwide. Treatment is based on benznidazole, producing several side effects and debatable efficacy, highlighting the need for new alternative drugs. We investigated the activity of four C-4 functionalized azlactone derivatives (EPA-27, EPA-35, EPA-63 and EPA-91) as potential T. cruzi inhibitors. Screening with epimastigotes indicated EPA-35 as the best compound (IC50/24 h: 33 μM). This compound was 14.1 times more potent against intracellular amastigotes (IC50/24 h: 2.34 μM). Treatment of infected Vero cells for 72 h (up to 30 μM EPA-35) resulted in a dose-dependent decrease in number of trypomastigotes and amastigotes released in the supernatant, but the amastigote/trypomastigote ratio remained constant, indicating that amastigote growth was disturbed, but cell differentiation was unaffected. Analysis of treated epimastigotes by flow cytometry indicated that the plasma membrane remained intact, but there was a significant decrease in mitochondrial membrane potential. The pattern of cell distribution in the cell cycle stages (G1, G2, M) was unaltered in treated epimastigotes, indicating a trypanocidal rather than a trypanostatic activity. Scanning electron microscopy and flow cytometry showed epimastigotes with a round shape and decrease in cell size. Taken together, our data indicate that the EPA-35 is effective against T. cruzi. Synthetic transformation of EPA-35 into other derivatives may provide promising compounds for further evaluation against this parasite. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-22
... of information: 1625-0080, Customer Satisfaction Surveys. Before submitting this ICR to OMB, the... FR 3316). Information Collection Request Title: Customer Satisfaction Surveys. OMB Control Number: 1625-0080. Summary: Executive Order 12862 authorizes the Coast Guard to survey customers to determine...
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The EPA collects information about facilities or sites subject to environmental regulation. The EPA Geospatial Data Access Project provides downloadable files of these facilities or sites in KML format.
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To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places subject to environmental regulation or of environmental interest. Through the Geospatial Data Download Service, the public is now able to download the EPA Geodata shapefile containing facility and site information from EPA's national program systems. The file is Internet accessible from the Envirofacts Web site (https://www3.epa.gov/enviro/). The data may be used with geospatial mapping applications. (Note: The shapefile omits facilities without latitude/longitude coordinates.) The EPA Geospatial Data contains the name, location (latitude/longitude), and EPA program information about specific facilities and sites. In addition, the file contains a Uniform Resource Locator (URL), which allows mapping applications to present an option to users to access additional EPA data resources on a specific facility or site. This dataset shows Brownfields listed in the 2012 Facility Registry System.
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ERIC Educational Resources Information Center
ACT, Inc., 2006
2006-01-01
ACT's Educational Planning and Assessment System (EPAS[R]) is designed to guide and support schools, districts, and states in their efforts to improve students' readiness for life after high school. EPAS provides a longitudinal approach to educational and career planning, assessment, instructional support, and evaluation. EPAS components are…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-17
..., Recovery/recycling. With each information collection covered in this ICR, EPA is aiding the goal of... technology and systems for the purposes of collecting, validating, and verifying information, processing and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-07
... Total Maximum Daily Load: Instrument, Pre-Test, and Implementation AGENCY: Environmental Protection..., Pre-test, and Implementation'' (EPA ICR No. 2456.01, OMB Control No. 2010-NEW) to the Office of...
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NASA Astrophysics Data System (ADS)
Smith, Donald F.; Aizikov, Konstantin; Duursma, Marc C.; Giskes, Frans; Spaanderman, Dirk-Jan; McDonnell, Liam A.; O'Connor, Peter B.; Heeren, Ron M. A.
2011-01-01
We describe the construction and application of a new MALDI source for FT-ICR mass spectrometry imaging. The source includes a translational X-Y positioning stage with a 10 × 10 cm range of motion for analysis of large sample areas, a quadrupole for mass selection, and an external octopole ion trap with electrodes for the application of an axial potential gradient for controlled ion ejection. An off-line LC MALDI MS/MS run demonstrates the utility of the new source for data- and position-dependent experiments. A FT-ICR MS imaging experiment of a coronal rat brain section yields ˜200 unique peaks from m/z 400-1100 with corresponding mass-selected images. Mass spectra from every pixel are internally calibrated with respect to polymer calibrants collected from an adjacent slide.
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EPA's Policy Permitting Limited Personal Use of Government Office Equipment for EPA Employees
This document provides the EPA policy permitting limited personal use of Government office equipment. EPA's intent in authorizing limited personal use of Government office equipment is to provide you with a professional and supportive work environment.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-29
..., environmental groups, academic institutions, industrial groups) use the ambient air quality data for many... requested in this ICR submit these data electronically to the U.S. EPA's Air Quality System (AQS) database...
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EPA's Information Architecture and Web Taxonomy
EPA's Information Architecture creates a topical organization of our website, instead of an ownership-based organization. The EPA Web Taxonomy allows audiences easy access to relevant information from EPA programs, by using a common vocabulary.
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EPA-DOT Memorandum of Understanding (MOU)
National Memorandum of Understanding Between the U.S. Department of Transportation and the U.S. Environmental Protection Agency (EPA Publication #EPA-420-F-00-020 and EPA-DOT Memorandum of Understanding (MOU) on Transportation Conformity.
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EPA GEOSPATIAL QUALITY COUNCIL STRATEGY PLAN FY-02
The EPA Geospatial Quality Council (GQC), previously known as the EPA GIS-QA Team - EPA/600/R-00/009, was created to fill the gap between the EPA Quality Assurance (QA) and Geospatial communities. All EPA Offices and Regions were invited to participate. Currently, the EPA... -
EPA OIG's RSS Feed - The EPA OIG offers an XML news feed (RSS) covering all of our publications and news. To use our pre-made feed, click on the link below, copy the URL, then paste it into your prefferred feed reader.
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-22
... Office of Management and Budget; OMB Control Numbers: 1625-0002, 1625-0017, 1625-0019, and 1625- 0030... (ICRs) and Analyses to the Office of Management and Budget (OMB) requesting an extension of its approval..., Waiver, and Continuous Synopsis Record; (2) 1625-0017, Various International Agreement Safety...
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US EPA Region 4 RMP Facilities
To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places subject to environmental regulation or of environmental interest. Through the Geospatial Data Download Service, the public is now able to download the EPA Geodata shapefile containing facility and site information from EPA's national program systems. The file is Internet accessible from the Envirofacts Web site (http://www.epa.gov/enviro). The data may be used with geospatial mapping applications. (Note: The shapefile omits facilities without latitude/longitude coordinates.) The EPA Geospatial Data contains the name, location (latitude/longitude), and EPA program information about specific facilities and sites. In addition, the file contains a Uniform Resource Locator (URL), which allows mapping applications to present an option to users to access additional EPA data resources on a specific facility or site.
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MyEnvironment | Envirofacts | US EPA
2017-09-22
The MyEnvironment search application is designed to provide a cross-section of environmental information based on the users location. Environmental data is displayed at local community locations. EPA Environmental data displayed within maps and reports. Results include: Environmental Data, Enviromental Map, EPA Data, EPA Map, Air, Water, Land, Health, Pollution, Climate Change, Permits, Statistics, Superfund, Brownfields, Hazardous Waste, Toxic, Releases, Cleanups, Community, Ecological Conditions
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EPA Facility Registry System (FRS): NEPT
This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link to the National Environmental Performance Track (NEPT) Program dataset. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs
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EPA Facility Registry Service (FRS): NEI
This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the National Emissions Inventory (NEI) Program dataset. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs
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EPA Solar Utilization in Higher Education Networking and Information Sharing Group
EPA's Green Power Partnership has a number of initiatives that focus on the collective green power efforts within specific sectors and renewable energy procurement strategies, which provide recognition opportunities for Partners and increase awareness.
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EPA scientific integrity policy draft
NASA Astrophysics Data System (ADS)
Showstack, Randy
2011-08-01
The U.S. Environmental Protection Agency (EPA) issued its draft scientific integrity policy on 5 August. The draft policy addresses scientific ethical standards, communications with the public, the use of advisory committees and peer review, and professional development. The draft policy was developed by an ad hoc group of EPA senior staff and scientists in response to a December 2010 memorandum on scientific integrity from the White House Office of Science and Technology Policy. The agency is accepting public comments on the draft through 6 September; comments should be sent to osa.staff@epa.gov. For more information, see http://www.epa.gov/stpc/pdfs/draft-scientific-integrity-policy-aug2011.pdf.
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40 CFR 147.1351 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.1351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Montana § 147.1351 EPA... within the exterior boundaries of the Fort Peck Indian Reservation, is administered by EPA. This program...
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40 CFR 147.1351 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.1351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Montana § 147.1351 EPA... within the exterior boundaries of the Fort Peck Indian Reservation, is administered by EPA. This program...
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40 CFR 147.1351 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.1351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Montana § 147.1351 EPA... within the exterior boundaries of the Fort Peck Indian Reservation, is administered by EPA. This program...
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40 CFR 147.1351 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.1351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Montana § 147.1351 EPA... within the exterior boundaries of the Fort Peck Indian Reservation, is administered by EPA. This program...
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40 CFR 147.1351 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.1351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Montana § 147.1351 EPA... within the exterior boundaries of the Fort Peck Indian Reservation, is administered by EPA. This program...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-09
... Liquid Chemicals Proposed for Bulk Water Movement; (2) 1625-0074, Direct User Fees for Inspection or... of Intent and Operations Manual; and (5) 1625-0102, National Response Resource Inventory. Our ICRs...: Direct User Fees for Inspection or Examination of U.S. and Foreign Commercial Vessels. OMB Control Number...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-10
... Office of Management and Budget; OMB Control Number: 1625-0109 AGENCY: Coast Guard, DHS. ACTION: Sixty....S. Coast Guard intends to submit an Information Collection Request (ICR) to the Office of Management...-0158] to the Docket Management Facility (DMF) at the U.S. Department of Transportation (DOT). To avoid...
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40 CFR 147.151 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona § 147.151 EPA..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted...
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40 CFR 147.101 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.101... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Alaska § 147.101 EPA..., and for all classes of wells on Indian lands, is administered by EPA. This program consists of the UIC...
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40 CFR 147.151 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona § 147.151 EPA..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted...
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40 CFR 147.801 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Iowa § 147.801 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.151 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona § 147.151 EPA..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted...
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40 CFR 147.601 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.601... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii § 147.601 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 725.17 - Consultation with EPA.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...
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40 CFR 147.801 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Iowa § 147.801 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.901 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.901... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Kentucky § 147.901 EPA... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124...
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40 CFR 147.601 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.601... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii § 147.601 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.901 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.901... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Kentucky § 147.901 EPA... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124...
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40 CFR 147.901 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.901... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Kentucky § 147.901 EPA... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124...
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40 CFR 147.801 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Iowa § 147.801 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.901 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.901... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Kentucky § 147.901 EPA... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124...
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40 CFR 147.801 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Iowa § 147.801 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.101 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.101... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Alaska § 147.101 EPA..., and for all classes of wells on Indian lands, is administered by EPA. This program consists of the UIC...
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40 CFR 725.17 - Consultation with EPA.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...
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40 CFR 147.601 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.601... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii § 147.601 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.101 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.101... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Alaska § 147.101 EPA..., and for all classes of wells on Indian lands, is administered by EPA. This program consists of the UIC...
-
40 CFR 147.601 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.601... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii § 147.601 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.801 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Iowa § 147.801 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 147.151 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona § 147.151 EPA..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted...
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40 CFR 725.17 - Consultation with EPA.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...
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40 CFR 147.151 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Arizona § 147.151 EPA..., including those on Indian lands, except for Class II wells on Navajo Indian lands for which EPA has granted...
-
40 CFR 147.601 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.601... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii § 147.601 EPA... administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124, 144, 146, 148...
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40 CFR 725.17 - Consultation with EPA.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...
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40 CFR 147.101 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.101... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Alaska § 147.101 EPA..., and for all classes of wells on Indian lands, is administered by EPA. This program consists of the UIC...
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40 CFR 147.901 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.901... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Kentucky § 147.901 EPA... lands, is administered by EPA. This program consists of the UIC program requirements of 40 CFR parts 124...
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40 CFR 147.751 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Indiana § 147.751 EPA..., III, IV, and V wells on non-Indian lands in the State of Indiana is administered by the EPA. The...
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40 CFR 147.751 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Indiana § 147.751 EPA..., III, IV, and V wells on non-Indian lands in the State of Indiana is administered by the EPA. The...
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40 CFR 147.751 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Indiana § 147.751 EPA..., III, IV, and V wells on non-Indian lands in the State of Indiana is administered by the EPA. The...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 31 2011-07-01 2011-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 32 2013-07-01 2013-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 31 2014-07-01 2014-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 32 2012-07-01 2012-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...
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Report: Congressionally Requested Report on EPA Staffing Levels and Total Costs for EPA Facilities
Report #09-P-0080, January 14, 2009. Additional information on the staffing levels, rental/lease fees, and utility and security costs for all of the EPA facilities and/or locations where EPA incurs costs associated with its employees.
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Cheminformatics Analysis of EPA ToxCast Chemical Libraries ...
An important goal of toxicology research is the development of robust methods that use in vitro and chemical structure information to predict in vivo toxicity endpoints. The US EPA ToxCast program is addressing this goal using ~600 in vitro assays to create bioactivity profiles on a set of 320 compounds, mostly pesticide actives, that have well characterized in vivo toxicity. These 320 compounds (EPA-320 set evaluated in Phase I of ToxCast) are a subset of a much larger set of ~10,000 candidates that are of interest to the EPA (called here EPA-10K). Predictive models of in vivo toxicity are being constructed from the in vitro assay data on the EPA-320 chemical set. These models require validation on additional chemicals prior to wide acceptance, and this will be carried out by evaluating compounds from EPA-10K in Phase II of ToxCast. We have used cheminformatics approaches including clustering, data visualization, and QSAR to develop models for EPA-320 that could help prioritizing EPA-10K validation chemicals. Both chemical descriptors, as well as calculated physicochemical properties have been used. Compounds from EPA-10K are prioritized based on their similarity to EPA-320 using different similarity metrics, with similarity thresholds defining the domain of applicability for the predictive models built for EPA-320 set. In addition, prioritized lists of compounds of increasing dissimilarity from the EPA-320 have been produced, to test the ability of the EPA-320
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U.S. EPAs Geospatial Data Access Project
To improve public health and the environment, the United States Environmental Protection Agency (EPA) collects information about facilities, sites, or places subject to environmental regulation or of environmental interest. Through the Geospatial Data Download Service, the public is now able to download the EPA Geodata Shapefile, Feature Class or extensible markup language (XML) file containing facility and site information from EPA's national program systems. The files are Internet accessible from the Envirofacts Web site (https://www3.epa.gov/enviro/). The data may be used with geospatial mapping applications. (Note: The files omit facilities without latitude/longitude coordinates.) The EPA Geospatial Data contains the name, location (latitude/longitude), and EPA program information about specific facilities and sites. In addition, the files contain a Uniform Resource Locator (URL), which allows mapping applications to present an option to users to access additional EPA data resources on a specific facility or site.
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EPA National Quality System Contacts
Web links and contacts for the individual quality systems developed in support of the EPA Quality System by each EPA Regional Office, National Program Office and ORD National Research Laboratory and Center.
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EPA Communications Stylebook: Writing Guide
For the most part, EPA follows the Associated Press (AP) Stylebook. Other requirements of basic punctuation and grammar and usage in EPA writing modify, supplement, or in some cases reiterate AP style.
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Watson, Henry; Cockbain, Andrew J; Spencer, Jade; Race, Amanda; Volpato, Milene; Loadman, Paul M; Toogood, Giles J; Hull, Mark A
2016-12-01
We investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver metastasis surgery (Cockbain et al., 2014) [8]. There was a significant increase in RBC EPA in the EPA group (n=43; median intervention 30 days; mean absolute 1.26[±0.14]% increase; P<0.001), but not in the placebo arm (n=45). EPA incorporation varied widely in EPA users and was not explained by treatment duration or compliance. There was little evidence of 'contamination' in the placebo group. The EPA level predicted tumour EPA content (r=0.36; P=0.03). Participants with post-treatment EPA≥1.22% (n=49) had improved OS compared with EPA <1.22% (n=29; HR 0.42[95%CI 0.16-0.95]). RBC EPA content should be evaluated as a biomarker of tumour exposure and clinical outcomes in future EPA trials in CRC patients. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Pressman, Jonathan G; Richardson, Susan D; Speth, Thomas F; Miltner, Richard J; Narotsky, Michael G; Hunter, E Sidney; Rice, Glenn E; Teuschler, Linda K; McDonald, Anthony; Parvez, Shahid; Krasner, Stuart W; Weinberg, Howard S; McKague, A Bruce; Parrett, Christopher J; Bodin, Nathalie; Chinn, Russell; Lee, Chih-Fen T; Simmons, Jane Ellen
2010-10-01
The U.S. Environmental Protection Agency's "Four Lab Study" involved participation of researchers from four national Laboratories and Centers of the Office of Research and Development along with collaborators from the water industry and academia. The study evaluated toxicological effects of complex disinfection byproduct (DBP) mixtures, with an emphasis on reproductive and developmental effects that have been associated with DBP exposures in some human epidemiologic studies. This paper describes a new procedure for producing chlorinated drinking water concentrate for animal toxicology experiments, comprehensive identification of >100 DBPs, and quantification of 75 priority and regulated DBPs. In the research reported herein, complex mixtures of DBPs were produced by concentrating a natural source water with reverse osmosis membranes, followed by addition of bromide and treatment with chlorine. By concentrating natural organic matter in the source water first and disinfecting with chlorine afterward, DBPs (including volatiles and semivolatiles) were formed and maintained in a water matrix suitable for animal studies. DBP levels in the chlorinated concentrate compared well to those from EPA's Information Collection Rule (ICR) and a nationwide study of priority unregulated DBPs when normalized by total organic carbon (TOC). DBPs were relatively stable over the course of the animal studies (125 days) with multiple chlorination events (every 5-14 days), and a significant portion of total organic halogen was accounted for through a comprehensive identification approach. DBPs quantified included regulated DBPs, priority unregulated DBPs, and additional DBPs targeted by the ICR. Many DBPs are reported for the first time, including previously undetected and unreported haloacids and haloamides. The new concentration procedure not only produced a concentrated drinking water suitable for animal experiments, but also provided a greater TOC concentration factor (136
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EPA Alternative Dispute Resolution Contacts
The success of EPA's ADR efforts depends on a network of talented and experienced professionals in Headquarters offices and EPA Regions. For Agency-wide ADR information, please contact the Conflict Prevention and Resolution Center.
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EPA Facility Registry Service (FRS): CAMDBS
This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Clean Air Markets Division Business System (CAMDBS). Administered by the EPA Clean Air Markets Division, within the Office of Air and Radiation, CAMDBS supports the implementation of market-based air pollution control programs, including the Acid Rain Program and regional programs designed to reduce the transport of ozone. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. This data set contains the subset of FRS integrated facilities that link to CAMDBS facilities once the CAMDBS data has been integrated into the FRS database. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs.
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EPA Facility Registry Service (FRS): RCRA
This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of hazardous waste facilities that link to the Resource Conservation and Recovery Act Information System (RCRAInfo). EPA's comprehensive information system in support of the Resource Conservation and Recovery Act (RCRA) of 1976 and the Hazardous and Solid Waste Amendments (HSWA) of 1984, RCRAInfo tracks many types of information about generators, transporters, treaters, storers, and disposers of hazardous waste. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. This data set contains the subset of FRS integrated facilities that link to RCRAInfo hazardous waste facilities once the RCRAInfo data has been integrated into the FRS database. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs
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Ecosystem Services - An Emerging Direction for the U.S.EPA
Forty years ago the United States Environmental Protection Agency (U.S.EPA) was formed to “protect human health and the environment”. In those days the environment was being severely, and obviously, degraded by any number of pollution inputs, and it was clear that a healthy envi...
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EPA has multiple ways for the public to engage with the Agency's innovative solutions and technologies, including cooperative research and development agreements, internships, student competitions, and EPA databases developers can use to make mobile apps.
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EPA-Registered Bed Bug Products
... Bugs EPA Registered Bed Bug Products EPA-Registered Bed Bug Products Resources Bed Bug Main Page Top Ten ... Where you can use the pesticide Pesticide type Bed Bug Search Tool Enter the information as described in ...
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Engineering of EPA/DHA omega-3 fatty acid production by Lactococcus lactis subsp. cremoris MG1363.
Amiri-Jami, Mitra; Lapointe, Gisele; Griffiths, Mansel W
2014-04-01
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to be of major importance in human health. Therefore, these essential polyunsaturated fatty acids have received considerable attention in both human and farm animal nutrition. Currently, fish and fish oils are the main dietary sources of EPA/DHA. To generate sustainable novel sources for EPA and DHA, the 35-kb EPA/DHA synthesis gene cluster was isolated from a marine bacterium, Shewanella baltica MAC1. To streamline the introduction of the genes into food-grade microorganisms such as lactic acid bacteria, unnecessary genes located upstream and downstream of the EPA/DHA gene cluster were deleted. Recombinant Escherichia coli harboring the 20-kb gene cluster produced 3.5- to 6.1-fold more EPA than those carrying the 35-kb DNA fragment coding for EPA/DHA synthesis. The 20-kb EPA/DHA gene cluster was cloned into a modified broad-host-range low copy number vector, pIL252m (4.7 kb, Ery) and expressed in Lactococcus lactis subsp. cremoris MG1363. Recombinant L. lactis produced DHA (1.35 ± 0.5 mg g(-1) cell dry weight) and EPA (0.12 ± 0.04 mg g(-1) cell dry weight). This is believed to be the first successful cloning and expression of EPA/DHA synthesis gene cluster in lactic acid bacteria. Our findings advance the future use of EPA/DHA-producing lactic acid bacteria in such applications as dairy starters, silage adjuncts, and animal feed supplements.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-19
... the comment includes profanity, threats, information claimed to be Confidential Business Information... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2009-0494; FRL-9752-9] Proposed Information... to submit an information collection request (ICR), ``Tips and Complaints Regarding Environmental...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-18
...- OECA-2010-0374, to (1) EPA online using http://www.regulations.gov (our preferred method), or by email... hours. This is due to a mathematical error in the previous ICR. The increase in cost to Respondents and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-22
... Submitted to OMB for Review and Approval; Comment Request; Reformulated Gasoline Commingling Provisions... Protection Agency has submitted an information collection request (ICR), Reformulated Gasoline Commingling...: EPA would like to continue collecting notifications from gasoline retailers and wholesale purchaser...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-29
..., unless the comment includes profanity, threats, information claimed to be Confidential Business... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OAR-2013-0437; FRL 9903-41-OEI] Information Collection... information collection request (ICR), Emission Control System Performance Warranty Regulations and Voluntary...
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Somogyi, Arpad; Oh, Chu-Ha; Smith, Mark A; Lunine, Jonathan I
2005-06-01
Laboratory simulations have been carried out to model chemical reactions that possibly take place in the stratosphere of Saturn's moon, Titan. The aerosol products of these reactions (tholin samples) have been systematically analyzed by mass spectrometry using electrospray ionization (ESI) and laser desorption (LD). A wide variety of ions with a general formula C(x)H(y)N(z) detected by ultrahigh resolution and accurate mass measurements in a Fourier transform/ion cyclotron resonance (FT-ICR) cell reflect the complexity of these polymeric products, both in chemical compositions and isomeric distributions. As a common feature, however, tandem mass spectral (MS/MS) data and H/D exchange products in the solution phase support the presence of amino and nitrile functionalities in these (highly unsaturated) "tholin" compounds. The present work demonstrates that ESI-MS coupled with FT-ICR is a suitable and "intact" method to analyze tholin components formed under anaerobic conditions; only species with C(x)H(y)N(z) are detected for freshly prepared and harvested samples. However, when intentionally exposed to water, oxygen-containing compounds are unambiguously detected.
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EPA Facility Registry Service (FRS): TRI
This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Toxic Release Inventory (TRI) System. TRI is a publicly available EPA database reported annually by certain covered industry groups, as well as federal facilities. It contains information about more than 650 toxic chemicals that are being used, manufactured, treated, transported, or released into the environment, and includes information about waste management and pollution prevention activities. FRS identifies and geospatially locates facilities, sites or places subject to environmental regulations or of environmental interest. Using vigorous verification and data management procedures, FRS integrates facility data from EPA's national program systems, other federal agencies, and State and tribal master facility records and provides EPA with a centrally managed, single source of comprehensive and authoritative information on facilities. This data set contains the subset of FRS integrated facilities that link to TRI facilities once the TRI data has been integrated into the FRS database. Additional information on FRS is available at the EPA website https://www.epa.gov/enviro/facility-registry-service-frs.
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PRN 97-4: Consumer Access Numbers on Pesticide Labels
This notice describes EPA policy on including telephone numbers and other access numbers or internet addresses, on pesticide product labeling. It also explains how the telephone number of the National Pesticide Information Center hotline may be used.
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40 CFR 67.41 - When EPA may review.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 16 2014-07-01 2014-07-01 false When EPA may review. 67.41 Section 67.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EPA APPROVAL OF STATE NONCOMPLIANCE PENALTY PROGRAM EPA Review of State Penalty Assessments § 67.41 When EPA...
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40 CFR 67.41 - When EPA may review.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 15 2010-07-01 2010-07-01 false When EPA may review. 67.41 Section 67.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EPA APPROVAL OF STATE NONCOMPLIANCE PENALTY PROGRAM EPA Review of State Penalty Assessments § 67.41 When EPA...
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40 CFR 67.41 - When EPA may review.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 16 2013-07-01 2013-07-01 false When EPA may review. 67.41 Section 67.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EPA APPROVAL OF STATE NONCOMPLIANCE PENALTY PROGRAM EPA Review of State Penalty Assessments § 67.41 When EPA...
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40 CFR 67.41 - When EPA may review.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 15 2011-07-01 2011-07-01 false When EPA may review. 67.41 Section 67.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EPA APPROVAL OF STATE NONCOMPLIANCE PENALTY PROGRAM EPA Review of State Penalty Assessments § 67.41 When EPA...
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40 CFR 67.41 - When EPA may review.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 16 2012-07-01 2012-07-01 false When EPA may review. 67.41 Section 67.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EPA APPROVAL OF STATE NONCOMPLIANCE PENALTY PROGRAM EPA Review of State Penalty Assessments § 67.41 When EPA...
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Silbermann, M; Levitan, S
1979-01-01
Pregnant ICR mice were treated with triamcinolone hexacetonide at various stages of gestation. The mandibular ramus and its condylar cartilage were studied histologically in both viable and non-viable offspring. In addition, measurements were made of the overall height of the posterior vertical dimension of the mandible and of condylar height and width. Significant changes were noted in these parameters. Concomitantly, marked changes were observed in the various zones of the condylar cartilage. A very high incidence of cleft palate was noted in newborn and stillborn mice previously treated with triamcinolone. A possible correlation between mandibular growth retardation and palatal clefting is discussed. Images Fig. 4 Fig. 5 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 Fig. 14 Fig. 15 PMID:489465
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-22
... personal information provided, unless the comment includes profanity, threats, information claimed to be... ENVIRONMENTAL PROTECTION AGENCY [EPA-OPP-2012-0544; FRL-9534-8] Information Collection Request... Environmental Protection Agency has submitted an information collection request (ICR), ``Notice of Supplemental...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-13
..., unless the comment includes profanity, threats, information claimed to be Confidential Business... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2009-0494; FRL 9527-7] Information Collection Request... Environmental Protection Agency has submitted an information collection request (ICR), ``Tips and Complaints...
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40 CFR 59.409 - Addresses of EPA Offices.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 6 2012-07-01 2012-07-01 false Addresses of EPA Offices. 59.409... National Volatile Organic Compound Emission Standards for Architectural Coatings § 59.409 Addresses of EPA... manufacturer or importer resides. These areas are indicated in the following list of EPA Regional Offices: EPA...
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40 CFR 59.409 - Addresses of EPA Offices.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 6 2013-07-01 2013-07-01 false Addresses of EPA Offices. 59.409... National Volatile Organic Compound Emission Standards for Architectural Coatings § 59.409 Addresses of EPA... manufacturer or importer resides. These areas are indicated in the following list of EPA Regional Offices: EPA...
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40 CFR 17.4 - Applicability to EPA proceedings.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Applicability to EPA proceedings. 17.4... ACCESS TO JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS General Provisions § 17.4 Applicability to EPA proceedings. The Act applies to an adversary adjudication pending before EPA at any time between October 1...
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40 CFR 59.409 - Addresses of EPA Offices.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 6 2014-07-01 2014-07-01 false Addresses of EPA Offices. 59.409... National Volatile Organic Compound Emission Standards for Architectural Coatings § 59.409 Addresses of EPA... manufacturer or importer resides. These areas are indicated in the following list of EPA Regional Offices: EPA...
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40 CFR 17.4 - Applicability to EPA proceedings.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Applicability to EPA proceedings. 17.4... ACCESS TO JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS General Provisions § 17.4 Applicability to EPA proceedings. The Act applies to an adversary adjudication pending before EPA at any time between October 1...
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40 CFR 17.4 - Applicability to EPA proceedings.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Applicability to EPA proceedings. 17.4... ACCESS TO JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS General Provisions § 17.4 Applicability to EPA proceedings. The Act applies to an adversary adjudication pending before EPA at any time between October 1...
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40 CFR 17.4 - Applicability to EPA proceedings.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Applicability to EPA proceedings. 17.4... ACCESS TO JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS General Provisions § 17.4 Applicability to EPA proceedings. The Act applies to an adversary adjudication pending before EPA at any time between October 1...
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40 CFR 17.4 - Applicability to EPA proceedings.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Applicability to EPA proceedings. 17.4... ACCESS TO JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS General Provisions § 17.4 Applicability to EPA proceedings. The Act applies to an adversary adjudication pending before EPA at any time between October 1...
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40 CFR 147.1951 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.1951... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Pennsylvania § 147.1951 EPA-administered program. (a) Contents. The UIC program for the State of Pennsylvania, including...
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40 CFR 147.1951 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.1951... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Pennsylvania § 147.1951 EPA-administered program. (a) Contents. The UIC program for the State of Pennsylvania, including...
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40 CFR 147.1951 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.1951... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Pennsylvania § 147.1951 EPA-administered program. (a) Contents. The UIC program for the State of Pennsylvania, including...
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40 CFR 147.1951 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.1951... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Pennsylvania § 147.1951 EPA-administered program. (a) Contents. The UIC program for the State of Pennsylvania, including...
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40 CFR 147.1951 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.1951... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Pennsylvania § 147.1951 EPA-administered program. (a) Contents. The UIC program for the State of Pennsylvania, including...
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With assistance from the Association of State and Territorial Air and Solid Waste Management Officials (ASTSWMO), the U.S. EPA Office of Underground Storage Tanks (OUST) and the U.S. EPA Office of Research and Development (ORD) conducted a survey to determine the distribution of ...
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Rubus coreanus Miquel ameliorates scopolamine-induced memory impairments in ICR mice.
Choi, Mi-Ran; Lee, Min Young; Hong, Ji Eun; Kim, Jeong Eun; Lee, Jae-Yong; Kim, Tae Hwan; Chun, Jang Woo; Shin, Hyun Kyung; Kim, Eun Ji
2014-10-01
The present study investigated the effect of Rubus coreanus Miquel (RCM) on scopolamine-induced memory impairments in ICR mice. Mice were orally administrated RCM for 4 weeks and scopolamine was intraperitoneally injected into mice to induce memory impairment. RCM improved the scopolamine-induced memory impairment in mice. The increase of acetylcholinesterase activity caused by scopolamine was significantly attenuated by RCM treatment. RCM increased the levels of acetylcholine in the brain and serum of mice. The expression of choline acetyltransferase, phospho-cyclic AMP response element-binding protein, and phospho-extracellular signal-regulated kinase was significantly increased within the brain of mice treated with RCM. The brain antioxidant enzyme activity decreased by scopolamine was increased by RCM. These results demonstrate that RCM exerts a memory-enhancing effect via the improvement of cholinergic function and the potentiated antioxidant activity in memory-impaired mice. The results suggest that RCM may be a useful agent for improving memory impairment.
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40 CFR 172.26 - EPA review of permits.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 24 2014-07-01 2014-07-01 false EPA review of permits. 172.26 Section... EXPERIMENTAL USE PERMITS State Issuance of Experimental Use Permits § 172.26 EPA review of permits. (a... designated State agency shall notifiy EPA of the action by forwarding to the appropriate EPA Regional Office...
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40 CFR 172.26 - EPA review of permits.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 25 2012-07-01 2012-07-01 false EPA review of permits. 172.26 Section... EXPERIMENTAL USE PERMITS State Issuance of Experimental Use Permits § 172.26 EPA review of permits. (a... designated State agency shall notifiy EPA of the action by forwarding to the appropriate EPA Regional Office...
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40 CFR 172.26 - EPA review of permits.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 23 2010-07-01 2010-07-01 false EPA review of permits. 172.26 Section... EXPERIMENTAL USE PERMITS State Issuance of Experimental Use Permits § 172.26 EPA review of permits. (a... designated State agency shall notifiy EPA of the action by forwarding to the appropriate EPA Regional Office...
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40 CFR 172.26 - EPA review of permits.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 25 2013-07-01 2013-07-01 false EPA review of permits. 172.26 Section... EXPERIMENTAL USE PERMITS State Issuance of Experimental Use Permits § 172.26 EPA review of permits. (a... designated State agency shall notifiy EPA of the action by forwarding to the appropriate EPA Regional Office...
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40 CFR 172.26 - EPA review of permits.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 24 2011-07-01 2011-07-01 false EPA review of permits. 172.26 Section... EXPERIMENTAL USE PERMITS State Issuance of Experimental Use Permits § 172.26 EPA review of permits. (a... designated State agency shall notifiy EPA of the action by forwarding to the appropriate EPA Regional Office...
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40 CFR 147.2751 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.2751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS American Samoa § 147.2751 EPA-administered program. (a) Contents. The UIC program for American Samoa, including all Indian...
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40 CFR 147.3100 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.3100... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Lands of Certain Oklahoma Indian Tribes § 147.3100 EPA-administered program. (a) Contents. The UIC program for the Indian...
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40 CFR 147.3100 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.3100... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Lands of Certain Oklahoma Indian Tribes § 147.3100 EPA-administered program. (a) Contents. The UIC program for the Indian...
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40 CFR 147.2151 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.2151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Tennessee § 147.2151 EPA-administered program. (a) Contents. The UIC program for the State of Tennessee, including all...
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40 CFR 147.1151 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.1151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Michigan § 147.1151 EPA-administered program. (a) Contents. The UIC program for the State of Michigan, including all...
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40 CFR 147.1151 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.1151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Michigan § 147.1151 EPA-administered program. (a) Contents. The UIC program for the State of Michigan, including all...
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40 CFR 147.2801 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.2801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Commonwealth of the Northern Mariana Islands § 147.2801 EPA-administered program. (a) Contents. The UIC program for Indian...
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40 CFR 147.1151 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.1151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Michigan § 147.1151 EPA-administered program. (a) Contents. The UIC program for the State of Michigan, including all...
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40 CFR 147.2351 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.2351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all...
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40 CFR 147.2801 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.2801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Commonwealth of the Northern Mariana Islands § 147.2801 EPA-administered program. (a) Contents. The UIC program for Indian...
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40 CFR 147.1151 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.1151... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Michigan § 147.1151 EPA-administered program. (a) Contents. The UIC program for the State of Michigan, including all...
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40 CFR 147.2351 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.2351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all...
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40 CFR 147.2701 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.2701... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virgin Islands § 147.2701 EPA-administered program. (a) Contents. The UIC program for the Virgin Islands, including all...
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40 CFR 147.2751 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.2751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS American Samoa § 147.2751 EPA-administered program. (a) Contents. The UIC program for American Samoa, including all Indian...
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40 CFR 147.2351 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.2351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all...
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40 CFR 147.2701 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.2701... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virgin Islands § 147.2701 EPA-administered program. (a) Contents. The UIC program for the Virgin Islands, including all...
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40 CFR 147.451 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.451... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS District of Columbia § 147.451 EPA-administered program. (a) Contents. The UIC program for the District of Columbia...
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40 CFR 147.451 - EPA-administered program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program. 147.451... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS District of Columbia § 147.451 EPA-administered program. (a) Contents. The UIC program for the District of Columbia...
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40 CFR 147.2751 - EPA-administered program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program. 147.2751... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS American Samoa § 147.2751 EPA-administered program. (a) Contents. The UIC program for American Samoa, including all Indian...
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40 CFR 147.2801 - EPA-administered program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program. 147.2801... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Commonwealth of the Northern Mariana Islands § 147.2801 EPA-administered program. (a) Contents. The UIC program for Indian...
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40 CFR 147.451 - EPA-administered program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program. 147.451... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS District of Columbia § 147.451 EPA-administered program. (a) Contents. The UIC program for the District of Columbia...
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40 CFR 147.2351 - EPA-administered program.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program. 147.2351... (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Virginia § 147.2351 EPA-administered program. (a) Contents. The UIC program for the State of Virginia, including all...