Sample records for identification number pin

  1. PINS Spectrum Identification Guide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    A.J. Caffrey

    2012-03-01

    The Portable Isotopic Neutron Spectroscopy—PINS, for short—system identifies the chemicals inside munitions and containers without opening them, a decided safety advantage if the fill chemical is a hazardous substance like a chemical warfare agent or an explosive. The PINS Spectrum Identification Guide is intended as a reference for technical professionals responsible for the interpretation of PINS gamma-ray spectra. The guide is divided into two parts. The three chapters that constitute Part I cover the science and technology of PINS. Neutron activation analysis is the focus of Chapter 1. Chapter 2 explores PINS hardware, software, and related operational issues. Gamma-ray spectralmore » analysis basics are introduced in Chapter 3. The six chapters of Part II cover the identification of PINS spectra in detail. Like the PINS decision tree logic, these chapters are organized by chemical element: phosphorus-based chemicals, chlorine-based chemicals, etc. These descriptions of hazardous, toxic, and/or explosive chemicals conclude with a chapter on the identification of the inert chemicals, e.g. sand, used to fill practice munitions.« less

  2. Optical fuel pin scanner. [Patent application; for reading identifications

    DOEpatents

    Kirchner, T.L.; Powers, H.G.

    1980-12-09

    This patent relates to an optical identification system developed for post-irradiation disassembly and analysis of fuel bundle assemblies. The apparatus is designed to be lowered onto a stationary fuel pin to read identification numbers or letters imprinted on the circumference of the top fuel pin and cap. (DLC)

  3. PINS Testing and Modification for Explosive Identification

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    E.H. Seabury; A.J. Caffrey

    2011-09-01

    The INL's Portable Isotopic Neutron Spectroscopy System (PINS)1 non-intrusively identifies the chemical fill of munitions and sealed containers. PINS is used routinely by the U.S. Army, the Defense Threat Reduction Agency, and foreign military units to determine the contents of munitions and other containers suspected to contain explosives, smoke-generating chemicals, and chemical warfare agents such as mustard and nerve gas. The objects assayed with PINS range from softball-sized M139 chemical bomblets to 200 gallon DOT 500X ton containers. INL had previously examined2 the feasibility of using a similar system for the identification of explosives, and based on this proof-of-principle test,more » the development of a dedicated system for the identification of explosives in an improvised nuclear device appears entirely feasible. INL has been tasked by NNSA NA-42 Render Safe Research and Development with the development of such a system.« less

  4. Pinning of fermionic occupation numbers.

    PubMed

    Schilling, Christian; Gross, David; Christandl, Matthias

    2013-01-25

    The Pauli exclusion principle is a constraint on the natural occupation numbers of fermionic states. It has been suspected since at least the 1970s, and only proved very recently, that there is a multitude of further constraints on these numbers, generalizing the Pauli principle. Here, we provide the first analytic analysis of the physical relevance of these constraints. We compute the natural occupation numbers for the ground states of a family of interacting fermions in a harmonic potential. Intriguingly, we find that the occupation numbers are almost, but not exactly, pinned to the boundary of the allowed region (quasipinned). The result suggests that the physics behind the phenomenon is richer than previously appreciated. In particular, it shows that for some models, the generalized Pauli constraints play a role for the ground state, even though they do not limit the ground-state energy. Our findings suggest a generalization of the Hartree-Fock approximation.

  5. Number of pins in two-stage stratified sampling for estimating herbage yield

    Treesearch

    William G. O' Regan; C. Eugene Conrad

    1975-01-01

    In a two-stage stratified procedure for sampling herbage yield, plots are stratified by a pin frame in stage one, and clipped. In stage two, clippings from selected plots are sorted, dried, and weighed. Sample size and distribution of plots between the two stages are determined by equations. A way to compute the effect of number of pins on the variance of estimated...

  6. Genome-wide identification and evolution of the PIN-FORMED (PIN) gene family in Glycine max.

    PubMed

    Liu, Yuan; Wei, Haichao

    2017-07-01

    Soybean (Glycine max) is one of the most important crop plants. Wild and cultivated soybean varieties have significant differences worth further investigation, such as plant morphology, seed size, and seed coat development; these characters may be related to auxin biology. The PIN gene family encodes essential transport proteins in cell-to-cell auxin transport, but little research on soybean PIN genes (GmPIN genes) has been done, especially with respect to the evolution and differences between wild and cultivated soybean. In this study, we retrieved 23 GmPIN genes from the latest updated G. max genome database; six GmPIN protein sequences were changed compared with the previous database. Based on the Plant Genome Duplication Database, 18 GmPIN genes have been involved in segment duplication. Three pairs of GmPIN genes arose after the second soybean genome duplication, and six occurred after the first genome duplication. The duplicated GmPIN genes retained similar expression patterns. All the duplicated GmPIN genes experienced purifying selection (K a /K s < 1) to prevent accumulation of non-synonymous mutations and thus remained more similar. In addition, we also focused on the artificial selection of the soybean PIN genes. Five artificially selected GmPIN genes were identified by comparing the genome sequence of 17 wild and 14 cultivated soybean varieties. Our research provides useful and comprehensive basic information for understanding GmPIN genes.

  7. RELATIONSHIP BETWEEN RIGIDITY OF EXTERNAL FIXATOR AND NUMBER OF PINS: COMPUTER ANALYSIS USING FINITE ELEMENTS

    PubMed Central

    Sternick, Marcelo Back; Dallacosta, Darlan; Bento, Daniela Águida; do Reis, Marcelo Lemos

    2015-01-01

    Objective: To analyze the rigidity of a platform-type external fixator assembly, according to different numbers of pins on each clamp. Methods: Computer simulation on a large-sized Cromus dynamic external fixator (Baumer SA) was performed using a finite element method, in accordance with the standard ASTM F1541. The models were generated with approximately 450,000 quadratic tetrahedral elements. Assemblies with two, three and four Schanz pins of 5.5 mm in diameter in each clamp were compared. Every model was subjected to a maximum force of 200 N, divided into 10 sub-steps. For the components, the behavior of the material was assumed to be linear, elastic, isotropic and homogeneous. For each model, the rigidity of the assembly and the Von Mises stress distribution were evaluated. Results: The rigidity of the system was 307.6 N/mm for two pins, 369.0 N/mm for three and 437.9 N/mm for four. Conclusion: The results showed that four Schanz pins in each clamp promoted rigidity that was 19% greater than in the configuration with three pins and 42% greater than with two pins. Higher tension occurred in configurations with fewer pins. In the models analyzed, the maximum tension occurred on the surface of the pin, close to the fixation area. PMID:27047879

  8. 7 CFR 75.48 - Identification number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Identification number. 75.48 Section 75.48 Agriculture... number. The Director may require the use of official identification numbers in connection with seed certificated or sampled under the Act. When identification numbers are required, they shall be specified by the...

  9. 7 CFR 75.48 - Identification number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Identification number. 75.48 Section 75.48 Agriculture... number. The Director may require the use of official identification numbers in connection with seed certificated or sampled under the Act. When identification numbers are required, they shall be specified by the...

  10. 7 CFR 75.48 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Identification number. 75.48 Section 75.48 Agriculture... number. The Director may require the use of official identification numbers in connection with seed certificated or sampled under the Act. When identification numbers are required, they shall be specified by the...

  11. 7 CFR 75.48 - Identification number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Identification number. 75.48 Section 75.48 Agriculture... number. The Director may require the use of official identification numbers in connection with seed certificated or sampled under the Act. When identification numbers are required, they shall be specified by the...

  12. 7 CFR 75.48 - Identification number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Identification number. 75.48 Section 75.48 Agriculture... number. The Director may require the use of official identification numbers in connection with seed certificated or sampled under the Act. When identification numbers are required, they shall be specified by the...

  13. 7 CFR 29.133 - Identification number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Identification number. 29.133 Section 29.133... REGULATIONS TOBACCO INSPECTION Regulations Miscellaneous § 29.133 Identification number. The Director may require the use of official identification numbers in connection with tobacco certificated or sampled...

  14. 7 CFR 29.133 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Identification number. 29.133 Section 29.133... REGULATIONS TOBACCO INSPECTION Regulations Miscellaneous § 29.133 Identification number. The Director may require the use of official identification numbers in connection with tobacco certificated or sampled...

  15. 7 CFR 29.133 - Identification number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Identification number. 29.133 Section 29.133... REGULATIONS TOBACCO INSPECTION Regulations Miscellaneous § 29.133 Identification number. The Director may require the use of official identification numbers in connection with tobacco certificated or sampled...

  16. 7 CFR 29.133 - Identification number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Identification number. 29.133 Section 29.133... REGULATIONS TOBACCO INSPECTION Regulations Miscellaneous § 29.133 Identification number. The Director may require the use of official identification numbers in connection with tobacco certificated or sampled...

  17. 7 CFR 29.133 - Identification number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Identification number. 29.133 Section 29.133... REGULATIONS TOBACCO INSPECTION Regulations Miscellaneous § 29.133 Identification number. The Director may require the use of official identification numbers in connection with tobacco certificated or sampled...

  18. 20 CFR 404.1220 - Identification numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Identification numbers. 404.1220 Section 404... § 404.1220 Identification numbers. (a) State and local governments. When a State submits a modification... will assign a special identification number to each political subdivision included in that modification...

  19. 20 CFR 404.1220 - Identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Identification numbers. 404.1220 Section 404... § 404.1220 Identification numbers. (a) State and local governments. When a State submits a modification... will assign a special identification number to each political subdivision included in that modification...

  20. 46 CFR 10.207 - Identification number.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Identification number. 10.207 Section 10.207 Shipping... CREDENTIAL General Requirements for All Merchant Mariner Credentials § 10.207 Identification number. For recordkeeping purposes only, a mariner's official MMC identification number is the individual's social security...

  1. 46 CFR 10.207 - Identification number.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Identification number. 10.207 Section 10.207 Shipping... CREDENTIAL General Requirements for All Merchant Mariner Credentials § 10.207 Identification number. For recordkeeping purposes only, a mariner's official MMC identification number is the individual's social security...

  2. 20 CFR 404.1220 - Identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Identification numbers. 404.1220 Section 404... § 404.1220 Identification numbers. (a) State and local governments. When a State submits a modification... will assign a special identification number to each political subdivision included in that modification...

  3. 20 CFR 404.1220 - Identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Identification numbers. 404.1220 Section 404... § 404.1220 Identification numbers. (a) State and local governments. When a State submits a modification... will assign a special identification number to each political subdivision included in that modification...

  4. 46 CFR 10.207 - Identification number.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Identification number. 10.207 Section 10.207 Shipping... CREDENTIAL General Requirements for All Merchant Mariner Credentials § 10.207 Identification number. For recordkeeping purposes only, a mariner's official MMC identification number is the individual's social security...

  5. 46 CFR 10.207 - Identification number.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Identification number. 10.207 Section 10.207 Shipping... CREDENTIAL General Requirements for All Merchant Mariner Credentials § 10.207 Identification number. For recordkeeping purposes only, a mariner's official MMC identification number is the individual's social security...

  6. 40 CFR 265.11 - Identification number.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

  7. 40 CFR 265.11 - Identification number.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

  8. 40 CFR 265.11 - Identification number.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

  9. 40 CFR 265.11 - Identification number.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

  10. 40 CFR 265.11 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Identification number. 265.11 Section... FACILITIES General Facility Standards § 265.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR...

  11. 40 CFR 264.11 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...

  12. 40 CFR 264.11 - Identification number.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...

  13. 40 CFR 264.11 - Identification number.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...

  14. 40 CFR 264.11 - Identification number.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...

  15. 40 CFR 264.11 - Identification number.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Identification number. 264.11 Section... Facility Standards § 264.11 Identification number. Every facility owner or operator must apply to EPA for an EPA identification number in accordance with the EPA notification procedures (45 FR 12746). [45 FR...

  16. 16 CFR 303.20 - Registered identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Registered identification numbers. 303.20... identification numbers. (a) Registered numbers for use as the required identification in lieu of the name on... the form set out in paragraph (d) of this section. (b)(1) Registered identification numbers shall be...

  17. 46 CFR 10.207 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... recordkeeping purposes only, a mariner's official MMC identification number is the individual's social security number. However, a unique serial number, and not the social security number, will appear on the... 46 Shipping 1 2010-10-01 2010-10-01 false Identification number. 10.207 Section 10.207 Shipping...

  18. 14 CFR 47.15 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGISTRATION General § 47.15 Identification number. (a) Number required. An applicant for Aircraft Registration must place a U.S. identification number (registration mark) on his Aircraft Registration Application... holder of a Dealer's Aircraft Registration Certificate who applies for a temporary registration number...

  19. 27 CFR 19.242 - Employer identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... number. 19.242 Section 19.242 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... for Employer Identification Numbers § 19.242 Employer identification number. The proprietor must enter the employer identification number (EIN) assigned to it by the Internal Revenue Service on each form...

  20. 16 CFR 301.26 - Registered identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Registered identification numbers. 301.26... numbers. (a) Registered numbers for use as the required identification in lieu of the name on fur product... (d) of this section. (b)(1) Registered identification numbers shall be used only by the person or...

  1. 7 CFR 29.32 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Identification number. 29.32 Section 29.32 Agriculture... INSPECTION Regulations Definitions § 29.32 Identification number. A number or a combination of letters and numbers in a design or mark approved by the Director, stamped, printed, or stenciled on a lot of tobacco...

  2. 7 CFR 29.32 - Identification number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Identification number. 29.32 Section 29.32 Agriculture... INSPECTION Regulations Definitions § 29.32 Identification number. A number or a combination of letters and numbers in a design or mark approved by the Director, stamped, printed, or stenciled on a lot of tobacco...

  3. 7 CFR 29.32 - Identification number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Identification number. 29.32 Section 29.32 Agriculture... INSPECTION Regulations Definitions § 29.32 Identification number. A number or a combination of letters and numbers in a design or mark approved by the Director, stamped, printed, or stenciled on a lot of tobacco...

  4. 7 CFR 29.32 - Identification number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Identification number. 29.32 Section 29.32 Agriculture... INSPECTION Regulations Definitions § 29.32 Identification number. A number or a combination of letters and numbers in a design or mark approved by the Director, stamped, printed, or stenciled on a lot of tobacco...

  5. 7 CFR 29.32 - Identification number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Identification number. 29.32 Section 29.32 Agriculture... INSPECTION Regulations Definitions § 29.32 Identification number. A number or a combination of letters and numbers in a design or mark approved by the Director, stamped, printed, or stenciled on a lot of tobacco...

  6. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  7. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  8. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  9. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  10. 40 CFR 262.12 - EPA identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false EPA identification numbers. 262.12... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.12 EPA identification numbers... waste without having received an EPA identification number from the Administrator. (b) A generator who...

  11. 20 CFR 422.112 - Employer identification numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Employer identification numbers. 422.112... Procedures § 422.112 Employer identification numbers. (a) General. Most employers are required by section...)-1 to obtain an employer identification number (EIN) and to include it on wage reports filed with SSA...

  12. 20 CFR 422.112 - Employer identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Employer identification numbers. 422.112... Procedures § 422.112 Employer identification numbers. (a) General. Most employers are required by section...)-1 to obtain an employer identification number (EIN) and to include it on wage reports filed with SSA...

  13. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Hull identification number... identification number display. Two identical hull identification numbers are required to be displayed on each boat hull. (a) The primary hull identification number must be affixed— (1) On boats with transoms, to...

  14. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Hull identification number... identification number display. Two identical hull identification numbers are required to be displayed on each boat hull. (a) The primary hull identification number must be affixed— (1) On boats with transoms, to...

  15. 33 CFR 181.29 - Hull identification number display.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Hull identification number... SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Identification of Boats § 181.29 Hull identification number display. Two identical hull identification numbers are required to be displayed on each...

  16. 33 CFR 181.25 - Hull identification number format.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Hull identification number format... (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Identification of Boats § 181.25 Hull identification number format. Each of the hull identification numbers required by § 181.23 must consist of twelve...

  17. Optical security system for the protection of personal identification information.

    PubMed

    Doh, Yang-Hoi; Yoon, Jong-Soo; Choi, Kyung-Hyun; Alam, Mohammad S

    2005-02-10

    A new optical security system for the protection of personal identification information is proposed. First, authentication of the encrypted personal information is carried out by primary recognition of a personal identification number (PIN) with the proposed multiplexed minimum average correlation energy phase-encrypted (MMACE_p) filter. The MMACE_p filter, synthesized with phase-encrypted training images, can increase the discrimination capability and prevent the leak of personal identification information. After the PIN is recognized, speedy authentication of personal information can be achieved through one-to-one optical correlation by means of the optical wavelet filter. The possibility of information counterfeiting can be significantly decreased with the double-identification process. Simulation results demonstrate the effectiveness of the proposed technique.

  18. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate office...

  19. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate office...

  20. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate office...

  1. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate office...

  2. 7 CFR 29.9205 - Identification number (farm serial number).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Identification number (farm serial number). 29.9205 Section 29.9205 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... number (farm serial number). The serial number assigned to an individual farm by the appropriate office...

  3. Pin Load Control Applied to Retractable Pin Tool Technology and its Characterization

    NASA Technical Reports Server (NTRS)

    Oelgoetz, Peter A.

    2000-01-01

    Until the development of retractable pin tool (RPT) technology, friction stir welding (FSW) was limited to constant thickness joining of aluminum materials and the choices of keyhole elimination focused on traditional fusion and plug weld repair techniques. An invention, US Patent Number 5,893,507, "Auto-Adjustable Pin Tool for Friction Stir Welding" assigned to NASA, demonstrated an approach to resolve these serious drawbacks. This approach brings forth a technique that allows the crater, or keyhole, to be closed out automatically at the end of the weld joint without adding any additional equipment or material. Also the probe length can be varied automatically in the weld joint to compensate for material thickness changes, such as, in a tapered joint. This paper reports the effects of pin extension and retraction rates in the weld joint and its correlation to weld quality. The investigation utilized a pin load-detecting device that was integrated in the Phase 2A RPT designed by Boeing for NASA/MSFC. The RPT modification provided pin load data that was accessed and used to eliminate root side indications and determine pin manipulation rates necessary to produce consistence homogeneous joints.

  4. Pin Load Control Applied to Retractable Pin Tool Technology and its Characterization

    NASA Technical Reports Server (NTRS)

    Oelgoetz, Peter

    2000-01-01

    Until the development of retractable pin tool (RPT) technology, friction stir welding (FSW) was limited to constant thickness joining of aluminum materials and the choices of keyhole elimination focused on traditional fusion and plug weld repair techniques. An invention, US Patent Number 5,893.507, "Auto-Adjustable Pin Tool for Friction Stir Welding" assigned to NASA, demonstrated an approach to resolve these serious drawbacks. This approach brings forth a technique that allows the crater, or keyhole, to be closed out automatically at the end of the weld joint without adding any additional equipment or material. Also the probe length can be varied automatically in the weld joint to compensate for material thickness changes, such as, in a tapered joint. This paper reports the effects of pin extension and retraction rates in the weld joint and its correlation to weld quality. The investigation utilized a pin load-detecting device that was integrated in the Phase 2A RPT designed by Boeing for NASA/MSFC. The RPT modification provided pin load data that was accessed and used to eliminate root side indications and determine pin manipulation rates necessary to produce consistence homogeneous joints.

  5. Pin Load Control Applied to Retractable Pin Tool Technology and Its Characterization

    NASA Technical Reports Server (NTRS)

    Olegoetz, P.

    1999-01-01

    Until the development of retractable pin tool (RPT) technology, friction stir welding (FSW) was limited to constant thickness joining of aluminum materials and the choices of keyhole elimination focused on traditional fusion and plug weld repair techniques. An invention, US Patent Number 5,893,507, "Auto-Adjustable Pin Tool for Friction Stir Welding" assigned to NASA, demonstrated an approach to resolve these serious drawbacks. This approach brings forth a technique that allows the crater, or keyhole, to be closed out automatically at the end of the weld joint without adding any additional equipment or material. Also the probe length can be varied automatically in the weld joint to compensate for material thickness changes, such as, in a tapered joint. This paper reports the effects of pin extension and retraction rates in the weld joint and its correlation to weld quality. The investigation utilized a pin load-detecting device that was integrated in the Phase IIA RPT designed by Boeing for NASA/MSFC. The RPT modification provided pin load data that was accessed and used to eliminate root side indications and determine pin manipulation rates necessary to produce consistence homogeneous joints.

  6. 19 CFR 24.5 - Filing identification number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Filing identification number. 24.5 Section 24.5... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.5 Filing identification number. (a) Generally..., Notification of Importer's Number or Application for Importer's Number, or Notice of Change of Name or Address...

  7. 19 CFR 24.5 - Filing identification number.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Filing identification number. 24.5 Section 24.5... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.5 Filing identification number. (a) Generally..., Notification of Importer's Number or Application for Importer's Number, or Notice of Change of Name or Address...

  8. 27 CFR 46.102 - Employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... number. 46.102 Section 46.102 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE....102 Employer identification number. (a) Requirement. The employer identification number (as defined in 26 CFR 301.7701-12) of the taxpayer who has been assigned such a number must be shown on each special...

  9. 27 CFR 31.115 - Employer identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... number. 31.115 Section 31.115 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE....115 Employer identification number. (a) Requirement. The employer identification number (as defined in 26 CFR 301.7701-12) of a dealer who has been assigned such a number must be shown on each...

  10. 19 CFR 24.5 - Filing identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Filing identification number. 24.5 Section 24.5... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.5 Filing identification number. (a) Generally..., Notification of Importer's Number or Application for Importer's Number, or Notice of Change of Name or Address...

  11. 27 CFR 40.359 - Employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... number. 40.359 Section 40.359 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... identification number. The employer identification number (EIN) (defined at 26 CFR 301.7701-12) of a manufacturer of cigarette papers and/or tubes who has been assigned such a number shall be shown on each...

  12. 27 CFR 53.22 - Employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... number. 53.22 Section 53.22 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... AMMUNITION Administrative and Miscellaneous Provisions § 53.22 Employer identification number. (a... earlier been assigned an employer identification number or has not applied for one, shall make an...

  13. 27 CFR 17.22 - Employer identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... number. 17.22 Section 17.22 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... NONBEVERAGE PRODUCTS Registration § 17.22 Employer identification number. Every person who claims drawback..., and Firearms Taxes, the employer identification number (EIN) assigned by the Internal Revenue Service...

  14. 49 CFR 172.338 - Replacement of identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Replacement of identification numbers. 172.338..., TRAINING REQUIREMENTS, AND SECURITY PLANS Marking § 172.338 Replacement of identification numbers. If more than one of the identification number markings on placards, orange panels, or white square-on-point...

  15. 49 CFR 172.338 - Replacement of identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Replacement of identification numbers. 172.338..., TRAINING REQUIREMENTS, AND SECURITY PLANS Marking § 172.338 Replacement of identification numbers. If more than one of the identification number markings on placards, orange panels, or white square-on-point...

  16. 49 CFR 172.338 - Replacement of identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Replacement of identification numbers. 172.338..., TRAINING REQUIREMENTS, AND SECURITY PLANS Marking § 172.338 Replacement of identification numbers. If more than one of the identification number markings on placards, orange panels, or white square-on-point...

  17. 33 CFR 181.23 - Hull identification numbers required.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Hull identification numbers... identification numbers required. (a) A manufacturer must identify each boat produced or imported with primary and secondary hull identification numbers permanently affixed in accordance with § 181.29 of this subpart. (b) A...

  18. 33 CFR 181.23 - Hull identification numbers required.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Hull identification numbers... identification numbers required. (a) A manufacturer must identify each boat produced or imported with primary and secondary hull identification numbers permanently affixed in accordance with § 181.29 of this subpart. (b) A...

  19. Local endwall heat/mass-transfer distributions in pin fin channels

    NASA Astrophysics Data System (ADS)

    Lau, S. C.; Kim, Y. S.; Han, J. C.

    1987-10-01

    Naphthalene sublimination experiments were conducted to study the effects of the pin configuration, the pin length-to-diameter ratio, and the entrance length on local endwall heat/mass transfer in a channel with short pin fins (pin length-to-diameter ratios of 0.5 and 1.0). The detailed distributions of the local endwall heat/mass-transfer coefficient were obtained for staggered and aligned arrays of pin fins, for the spanwise pin spacing-to-diameter ratio of 2.5, and for streamwise pin spacing-to-diameter ratios of 1.25 and 2.5. The Reynolds numbers were kept at about 33,000. Overall- and row-averaged Nusselt numbers compared very well with those from previous heat-transfer studies.

  20. 15 CFR 14.18 - Taxpayer identification number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Taxpayer identification number. 14.18... COMMERCIAL ORGANIZATIONS Pre-Award Requirements § 14.18 Taxpayer identification number. In accordance with... identifying number will be required from applicants for grants and cooperative agreements funded by the DoC...

  1. 16 CFR 303.20 - Registered identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... identification numbers. (a) Registered numbers for use as the required identification in lieu of the name on.... When so used by the person or firm to whom assigned, the use of the numbers shall be construed as..., Federal Trade Commission, 600 Pennsylvania Avenue, NW., Washington, DC 20580, or on the Internet at http...

  2. 27 CFR 40.169 - Employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... number. 40.169 Section 40.169 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Payment of Taxes on Tobacco Products § 40.169 Employer identification number. The employer identification number (defined at 26 CFR 301.7701-12) of a manufacturer of tobacco products who has been assigned such a...

  3. 33 CFR 181.23 - Hull identification numbers required.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Hull identification numbers... SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Identification of Boats § 181.23 Hull... identify each boat produced or imported with two hull identification numbers that meet the requirements of...

  4. 40 CFR 263.11 - EPA identification number.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...

  5. 40 CFR 263.11 - EPA identification number.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...

  6. 40 CFR 263.11 - EPA identification number.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...

  7. 40 CFR 263.11 - EPA identification number.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...

  8. 40 CFR 263.11 - EPA identification number.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false EPA identification number. 263.11... (CONTINUED) STANDARDS APPLICABLE TO TRANSPORTERS OF HAZARDOUS WASTE General § 263.11 EPA identification number. (a) A transporter must not transport hazardous wastes without having received an EPA...

  9. Effects of Pin Detached Space on Heat Transfer and Pin-Fin Arrays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siw, Sin Chien; Chyu, Minking K.; Shih, Tom I. -P.

    2012-01-01

    Heat transfer and pressure characteristics in a rectangular channel with pin-fin arrays of partial detachment from one of the endwalls have been experimentally studied. The overall channel geometry (W=76.2 mm, E=25.4 mm) simulates an internal cooling passage of wide aspect ratio (3:1) in a gas turbine airfoil. With a given pin diameter, D=6.35 mm=¼E, three different pin-fin height-to-diameter ratios, H/D=4, 3, and 2, were examined. Each of these three cases corresponds to a specific pin array geometry of detachment spacing (C) between the pin tip and one of the endwalls, i.e., C/D=0, 1, 2, respectively. The Reynolds number, based onmore » the hydraulic diameter of the unobstructed cross-section and the mean bulk velocity, ranges from 10,000 to 25,000. The experiment employs a hybrid technique based on transient liquid crystal imaging to obtain the distributions of the local heat transfer coefficient over all of the participating surfaces, including the endwalls and all the pin elements. Experimental results reveal that the presence of a detached space between the pin tip and the endwall has a significant effect on the convective heat transfer and pressure loss in the channel. The presence of pin-to-endwall spacing promotes wall-flow interaction, generates additional separated shear layers, and augments turbulent transport. In general, an increase in detached spacing, or C/D, leads to lower heat transfer enhancement and pressure drop. However, C/D=1, i.e., H/D=3, of a staggered array configuration exhibits the highest heat transfer enhancement, followed by the cases of C/D=0 and C/D=2, i.e., H/D=4 or 2, respectively.« less

  10. 40 CFR 761.202 - EPA identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false EPA identification numbers. 761.202... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA...

  11. 40 CFR 761.202 - EPA identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false EPA identification numbers. 761.202... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA...

  12. 40 CFR 761.202 - EPA identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false EPA identification numbers. 761.202... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA...

  13. 40 CFR 761.202 - EPA identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any generator, commercial storer, transporter, or disposer of PCB waste who is required to have an EPA identification number under this subpart must notify EPA of his/her PCB waste handling activities, using the...

  14. Heat transfer and pressure drop in a compact pin-fin heat exchanger with pin orientation at 18 deg to the flow direction

    NASA Technical Reports Server (NTRS)

    Olson, D. A.

    1991-01-01

    The heat transfer and pressure drop characteristics of a novel, compact heat exchanger in helium gas were measured at 3.5 MPa and Reynolds numbers of 450 to 12,000. The pin-fin specimen consisted of pins, 0.51 mm high and spaced 2.03 mm on centers, spanning a channel through which the helium flows; the angle of the row of pins to the flow direction was 18 deg. The specimen was radiatively heated on the top side at heat fluxes up to 74 W/sq cm and insulated on the back side. Correlations were developed for the friction factor and Nusselt number. The Nusselt number compares favorably to those of past studies of staggered pin-fins, when the measured temperatures are extrapolated to the temperature of the wall-fluid interface.

  15. 40 CFR 761.202 - EPA identification numbers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.202 EPA identification numbers. (a) General. Any... identification number from EPA. (4) A disposer of PCB waste shall not accept any PCB waste for disposal without... disposal facility or mobile treatment unit shall not accept waste unless the disposer has received an EPA...

  16. 26 CFR 31.6011(b)-1 - Employers' identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 15 2013-04-01 2013-04-01 false Employers' identification numbers. 31.6011(b)-1... Subtitle F, Internal Revenue Code of 1954) § 31.6011(b)-1 Employers' identification numbers. (a... Insurance Contributions Act, but who prior to such day neither has been assigned an identification number...

  17. 26 CFR 31.6011(b)-1 - Employers' identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 15 2014-04-01 2014-04-01 false Employers' identification numbers. 31.6011(b)-1... Subtitle F, Internal Revenue Code of 1954) § 31.6011(b)-1 Employers' identification numbers. (a... Insurance Contributions Act, but who prior to such day neither has been assigned an identification number...

  18. Heat transfer coefficients for staggered arrays of short pin fins

    NASA Technical Reports Server (NTRS)

    Vanfossen, G. J.

    1981-01-01

    Short pin fins are often used to increase that heat transfer to the coolant in the trailing edge of a turbine blade. Due primarily to limits of casting technology, it is not possible to manufacture pins of optimum length for heat transfer purposes in the trailing edge region. In many cases the pins are so short that they actually decrease the total heat transfer surface area compared to a plain wall. A heat transfer data base for these short pins is not available in the literature. Heat transfer coefficients on pin and endwall surfaces were measured for several staggered arrays of short pin fins. The measured Nusselt numbers when plotted versus Reynolds numbers were found to fall on a single curve for all surfaces tested. The heat transfer coefficients for the short pin fins (length to diameter ratios of 1/2 and 2) were found to be about a factor of two lower than data from the literature for longer pin arrays (length to diameter ratios of about 8).

  19. Characterization of holding brake friction pad surface after pin-on-plate wear test

    NASA Astrophysics Data System (ADS)

    Drago, N.; Gonzalez Madruga, D.; De Chiffre, L.

    2018-03-01

    This article concerns the metrological characterization of the surface on a holding brake friction material pin after a pin-on-plate (POP) wear test. The POP test induces the formation of surface plateaus that affect brake performances such as wear, friction, noise and heat. Three different materials’ surfaces have been characterized after wear from data obtained with a focus variation 3D microscope. A new surface characterization approach with plateau identification is proposed, using the number of plateau on the surface, equivalent diameter, length and breadth as measurands. The identification method is based on determining and imposing ISO 27158-2 lower plateau limit (LPL) in material probability curves; and on applying a combined criterion of height segmentation threshold and equivalent diameter threshold. The method determines the criterion thresholds for each material since LPL appears typical by material. The proposed method has allowed quantifying the surface topography at two different levels of wear. An expanded measurement uncertainty of 3.5 µm for plateau dimensions in the range 50–2000 µm and one of 0.15 µm for plateau heights up to 10 µm have been documented.

  20. Pin1At regulates PIN1 polar localization and root gravitropism

    PubMed Central

    Xi, Wanyan; Gong, Ximing; Yang, Qiaoyun; Yu, Hao; Liou, Yih-Cherng

    2016-01-01

    Root gravitropism allows plants to establish root systems and its regulation depends on polar auxin transport mediated by PIN-FORMED (PIN) auxin transporters. PINOID (PID) and PROTEIN PHOSPHATASE 2A (PP2A) act antagonistically on reversible phosphorylation of PINs. This regulates polar PIN distribution and auxin transport. Here we show that a peptidyl-prolyl cis/trans isomerase Pin1At regulates root gravitropism. Downregulation of Pin1At suppresses root agravitropic phenotypes of pp2aa and 35S:PID, while overexpression of Pin1At affects root gravitropic responses and enhances the pp2aa agravitropic phenotype. Pin1At also affects auxin transport and polar localization of PIN1 in stele cells, which is mediated by PID and PP2A. Furthermore, Pin1At catalyses the conformational change of the phosphorylated Ser/Thr-Pro motifs of PIN1. Thus, Pin1At mediates the conformational dynamics of PIN1 and affects PID- and PP2A-mediated regulation of PIN1 polar localization, which correlates with the regulation of root gravitropism. PMID:26791759

  1. Pin1At regulates PIN1 polar localization and root gravitropism.

    PubMed

    Xi, Wanyan; Gong, Ximing; Yang, Qiaoyun; Yu, Hao; Liou, Yih-Cherng

    2016-01-21

    Root gravitropism allows plants to establish root systems and its regulation depends on polar auxin transport mediated by PIN-FORMED (PIN) auxin transporters. PINOID (PID) and PROTEIN PHOSPHATASE 2A (PP2A) act antagonistically on reversible phosphorylation of PINs. This regulates polar PIN distribution and auxin transport. Here we show that a peptidyl-prolyl cis/trans isomerase Pin1At regulates root gravitropism. Downregulation of Pin1At suppresses root agravitropic phenotypes of pp2aa and 35S:PID, while overexpression of Pin1At affects root gravitropic responses and enhances the pp2aa agravitropic phenotype. Pin1At also affects auxin transport and polar localization of PIN1 in stele cells, which is mediated by PID and PP2A. Furthermore, Pin1At catalyses the conformational change of the phosphorylated Ser/Thr-Pro motifs of PIN1. Thus, Pin1At mediates the conformational dynamics of PIN1 and affects PID- and PP2A-mediated regulation of PIN1 polar localization, which correlates with the regulation of root gravitropism.

  2. 24 CFR 200.6 - Employer identification and social security numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Employer identification and social... identification and social security numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of social security numbers and employer identification numbers by applicants and...

  3. 24 CFR 200.6 - Employer identification and social security numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Employer identification and social... identification and social security numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of social security numbers and employer identification numbers by applicants and...

  4. 24 CFR 200.6 - Employer identification and social security numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Employer identification and social... identification and social security numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of social security numbers and employer identification numbers by applicants and...

  5. 24 CFR 200.6 - Employer identification and social security numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Employer identification and social... identification and social security numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of social security numbers and employer identification numbers by applicants and...

  6. 24 CFR 200.6 - Employer identification and social security numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Employer identification and social... identification and social security numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of social security numbers and employer identification numbers by applicants and...

  7. PINS-3X Operations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    E.H. Seabury

    2013-09-01

    Idaho National Laboratory’s (INL’s) Portable Isotopic Neutron Spectroscopy System (PINS) non-intrusively identifies the chemical fill of munitions and sealed containers. The PINS-3X variant of the system is used to identify explosives and uses a deuterium-tritium (DT) electronic neutron generator (ENG) as the neutron source. Use of the system, including possession and use of the neutron generator and shipment of the system components requires compliance with a number of regulations. This report outlines some of these requirements as well as some of the requirements in using the system outside of INL.

  8. 41 CFR 109-38.5203 - Watercraft identification and numbers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... identification and numbers. 109-38.5203 Section 109-38.5203 Public Contracts and Property Management Federal... Watercraft identification and numbers. Watercraft in the custody of DOE or designated contractors shall display identifying numbers, whether issued by the U.S. Coast Guard, State, or local field organization...

  9. Method and apparatus for enhancing vortex pinning by conformal crystal arrays

    DOEpatents

    Janko, Boldizsar; Reichhardt, Cynthia; Reichhardt, Charles; Ray, Dipanjan

    2015-07-14

    Disclosed is a method and apparatus for strongly enhancing vortex pinning by conformal crystal arrays. The conformal crystal array is constructed by a conformal transformation of a hexagonal lattice, producing a non-uniform structure with a gradient where the local six-fold coordination of the pinning sites is preserved, and with an arching effect. The conformal pinning arrays produce significantly enhanced vortex pinning over a much wider range of field than that found for other vortex pinning geometries with an equivalent number of vortex pinning sites, such as random, square, and triangular.

  10. Pinning impulsive control algorithms for complex network

    NASA Astrophysics Data System (ADS)

    Sun, Wen; Lü, Jinhu; Chen, Shihua; Yu, Xinghuo

    2014-03-01

    In this paper, we further investigate the synchronization of complex dynamical network via pinning control in which a selection of nodes are controlled at discrete times. Different from most existing work, the pinning control algorithms utilize only the impulsive signals at discrete time instants, which may greatly improve the communication channel efficiency and reduce control cost. Two classes of algorithms are designed, one for strongly connected complex network and another for non-strongly connected complex network. It is suggested that in the strongly connected network with suitable coupling strength, a single controller at any one of the network's nodes can always pin the network to its homogeneous solution. In the non-strongly connected case, the location and minimum number of nodes needed to pin the network are determined by the Frobenius normal form of the coupling matrix. In addition, the coupling matrix is not necessarily symmetric or irreducible. Illustrative examples are then given to validate the proposed pinning impulsive control algorithms.

  11. 40 CFR 86.414-78 - Submission of vehicle identification number.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Submission of vehicle identification... vehicle identification number. (a) Upon request by the Administrator, the manufacturer of any motorcycle covered by a certificate of conformity shall, within 30 days, identify by vehicle identification number...

  12. 40 CFR 86.414-78 - Submission of vehicle identification number.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Submission of vehicle identification... vehicle identification number. (a) Upon request by the Administrator, the manufacturer of any motorcycle covered by a certificate of conformity shall, within 30 days, identify by vehicle identification number...

  13. 40 CFR 86.414-78 - Submission of vehicle identification number.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Submission of vehicle identification... vehicle identification number. (a) Upon request by the Administrator, the manufacturer of any motorcycle covered by a certificate of conformity shall, within 30 days, identify by vehicle identification number...

  14. 40 CFR 86.414-78 - Submission of vehicle identification number.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Submission of vehicle identification... vehicle identification number. (a) Upon request by the Administrator, the manufacturer of any motorcycle covered by a certificate of conformity shall, within 30 days, identify by vehicle identification number...

  15. 40 CFR 86.414-78 - Submission of vehicle identification number.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Submission of vehicle identification... vehicle identification number. (a) Upon request by the Administrator, the manufacturer of any motorcycle covered by a certificate of conformity shall, within 30 days, identify by vehicle identification number...

  16. Functionally different PIN proteins control auxin flux during bulbil development in Agave tequilana

    PubMed Central

    Abraham Juárez, María Jazmín; Hernández Cárdenas, Rocío; Santoyo Villa, José Natzul; O’Connor, Devin; Sluis, Aaron; Hake, Sarah; Ordaz-Ortiz, José; Terry, Leon; Simpson, June

    2015-01-01

    In Agave tequilana, reproductive failure or inadequate flower development stimulates the formation of vegetative bulbils at the bracteoles, ensuring survival in a hostile environment. Little is known about the signals that trigger this probably unique phenomenon in agave species. Here we report that auxin plays a central role in bulbil development and show that the localization of PIN1-related proteins is consistent with altered auxin transport during this process. Analysis of agave transcriptome data led to the identification of the A. tequilana orthologue of PIN1 (denoted AtqPIN1) and a second closely related gene from a distinct clade reported as ‘Sister of PIN1’ (denoted AtqSoPIN1). Quantitative real-time reverse transcription–PCR (RT-qPCR) analysis showed different patterns of expression for each gene during bulbil formation, and heterologous expression of the A. tequilana PIN1 and SoPIN1 genes in Arabidopsis thaliana confirmed functional differences between these genes. Although no free auxin was detected in induced pedicel samples, changes in the levels of auxin precursors were observed. Taken as a whole, the data support the model that AtqPIN1 and AtqSoPIN1 have co-ordinated but distinct functions in relation to auxin transport during the initial stages of bulbil formation. PMID:25911746

  17. 40 CFR 86.079-36 - Submission of vehicle identification numbers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Submission of vehicle identification... identification numbers. (a) Upon request of the Administrator, the manufacturer of any light-duty vehicle or... identification number, the vehicle(s) covered by the certificate of conformity. (b) The manufacturer of any light...

  18. 40 CFR 86.079-36 - Submission of vehicle identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Submission of vehicle identification... identification numbers. (a) Upon request of the Administrator, the manufacturer of any light-duty vehicle or... identification number, the vehicle(s) covered by the certificate of conformity. (b) The manufacturer of any light...

  19. 40 CFR 86.079-36 - Submission of vehicle identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Submission of vehicle identification... identification numbers. (a) Upon request of the Administrator, the manufacturer of any light-duty vehicle or... identification number, the vehicle(s) covered by the certificate of conformity. (b) The manufacturer of any light...

  20. 40 CFR 86.079-36 - Submission of vehicle identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Submission of vehicle identification... identification numbers. (a) Upon request of the Administrator, the manufacturer of any light-duty vehicle or... identification number, the vehicle(s) covered by the certificate of conformity. (b) The manufacturer of any light...

  1. Steel pin and hanger assembly replacement options : final report.

    DOT National Transportation Integrated Search

    2017-01-01

    A number of steel beam bridges exist in the United States that contain pin and hanger assemblies. Pin and hanger assemblies are fracture critical members whose failure would result in collapse of the bridge or render it unable to perform its expected...

  2. 76 FR 7757 - Hull Identification Numbers for Recreational Vessels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 181 [Docket No. USCG-2007-29236] Hull Identification Numbers for Recreational Vessels AGENCY: Coast Guard, DHS. ACTION: Follow-up to request for... expanded hull identification number (HIN). The Coast Guard's decision-making process included consideration...

  3. 49 CFR Appendix D to Part 512 - Vehicle Identification Number Information

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Vehicle Identification Number Information D.... 512, App. D Appendix D to Part 512—Vehicle Identification Number Information The Chief Counsel has...) characters, of vehicle identification numbers reported in information on incidents involving death or injury...

  4. 49 CFR Appendix D to Part 512 - Vehicle Identification Number Information

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Vehicle Identification Number Information D.... 512, App. D Appendix D to Part 512—Vehicle Identification Number Information The Chief Counsel has...) characters, of vehicle identification numbers reported in information on incidents involving death or injury...

  5. 49 CFR Appendix D to Part 512 - Vehicle Identification Number Information

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Vehicle Identification Number Information D.... 512, App. D Appendix D to Part 512—Vehicle Identification Number Information The Chief Counsel has...) characters, of vehicle identification numbers reported in information on incidents involving death or injury...

  6. 49 CFR Appendix D to Part 512 - Vehicle Identification Number Information

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Vehicle Identification Number Information D.... 512, App. D Appendix D to Part 512—Vehicle Identification Number Information The Chief Counsel has...) characters, of vehicle identification numbers reported in information on incidents involving death or injury...

  7. 77 FR 59575 - Hull Identification Numbers for Recreational Vessels

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 181 [Docket No. USCG-2012-0843] Hull Identification Numbers for Recreational Vessels AGENCY: Coast Guard, DHS. ACTION: Request for public comments... requirement to indicate a boat's model year as part of the 12-character Hull Identification Number (HIN...

  8. Orientation-modulated attention effect on visual evoked potential: Application for PIN system using brain-computer interface.

    PubMed

    Wilaiprasitporn, Theerawit; Yagi, Tohru

    2015-01-01

    This research demonstrates the orientation-modulated attention effect on visual evoked potential. We combined this finding with our previous findings about the motion-modulated attention effect and used the result to develop novel visual stimuli for a personal identification number (PIN) application based on a brain-computer interface (BCI) framework. An electroencephalography amplifier with a single electrode channel was sufficient for our application. A computationally inexpensive algorithm and small datasets were used in processing. Seven healthy volunteers participated in experiments to measure offline performance. Mean accuracy was 83.3% at 13.9 bits/min. Encouraged by these results, we plan to continue developing the BCI-based personal identification application toward real-time systems.

  9. Reduction of halo pin site morbidity with a new pin care regimen.

    PubMed

    Kazi, Hussain Anthony; de Matas, Marcus; Pillay, Robin

    2013-06-01

    A retrospective analysis of halo device associated morbidity over a 4-year period. To assess the impact of a new pin care regimen on halo pin site related morbidity. Halo orthosis treatment still has a role in cervical spine pathology, despite increasing possibilities of open surgical treatment. Published figures for pin site infection range from 12% to 22% with pin loosening from 7% to 50%. We assessed the outcome of a new pin care regimen on morbidity associated with halo spinal orthoses, using a retrospective cohort study from 2001 to 2004. In the last two years, our pin care regimen was changed. This involved pin site care using chlorhexidene & regular torque checking as part of a standard protocol. Previously, povidone iodine was used as skin preparation in theatre, followed by regular sterile saline cleansing when pin sites became encrusted with blood. There were 37 patients in the series, the median age was 49 (range, 22-83) and 20 patients were male. The overall infection rate prior to the new pin care protocol was 30% (n=6) and after the introduction, it dropped to 5.9% (n=1). This difference was statistically significant (p<0.05). Pin loosening occurred in one patient in the group prior to the formal pin care protocol (3%) and none thereafter. Reduced morbidity from halo use can be achieved with a modified pin cleansing and tightening regimen.

  10. Functionally different PIN proteins control auxin flux during bulbil development in Agave tequilana.

    PubMed

    Abraham Juárez, María Jazmín; Hernández Cárdenas, Rocío; Santoyo Villa, José Natzul; O'Connor, Devin; Sluis, Aaron; Hake, Sarah; Ordaz-Ortiz, José; Terry, Leon; Simpson, June

    2015-07-01

    In Agave tequilana, reproductive failure or inadequate flower development stimulates the formation of vegetative bulbils at the bracteoles, ensuring survival in a hostile environment. Little is known about the signals that trigger this probably unique phenomenon in agave species. Here we report that auxin plays a central role in bulbil development and show that the localization of PIN1-related proteins is consistent with altered auxin transport during this process. Analysis of agave transcriptome data led to the identification of the A. tequilana orthologue of PIN1 (denoted AtqPIN1) and a second closely related gene from a distinct clade reported as 'Sister of PIN1' (denoted AtqSoPIN1). Quantitative real-time reverse transcription-PCR (RT-qPCR) analysis showed different patterns of expression for each gene during bulbil formation, and heterologous expression of the A. tequilana PIN1 and SoPIN1 genes in Arabidopsis thaliana confirmed functional differences between these genes. Although no free auxin was detected in induced pedicel samples, changes in the levels of auxin precursors were observed. Taken as a whole, the data support the model that AtqPIN1 and AtqSoPIN1 have co-ordinated but distinct functions in relation to auxin transport during the initial stages of bulbil formation. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  11. Pin routability and pin access analysis on standard cells for layout optimization

    NASA Astrophysics Data System (ADS)

    Chen, Jian; Wang, Jun; Zhu, ChengYu; Xu, Wei; Li, Shuai; Lin, Eason; Ou, Odie; Lai, Ya-Chieh; Qu, Shengrui

    2018-03-01

    At advanced process nodes, especially at sub-28nm technology, pin accessibility and routability of standard cells has become one of the most challenging design issues due to the limited router tracks and the increased pin density. If this issue can't be found and resolved during the cell design stage, the pin access problem will be very difficult to be fixed in implementation stage and will make the low efficiency for routing. In this paper, we will introduce a holistic approach for the pin accessibility scoring and routability analysis. For accessibility, the systematic calculator which assigns score for each pin will search the available access points, consider the surrounded router layers, basic design rule and allowed via geometry. Based on the score, the "bad" pins can be found and modified. On pin routability analysis, critical pin points (placing via on this point would lead to failed via insertion) will be searched out for either layout optimization guide or set as OBS for via insertion blocking. By using this pin routability and pin access analysis flow, we are able to improve the library quality and performance.

  12. Identifying partial topology of complex dynamical networks via a pinning mechanism

    NASA Astrophysics Data System (ADS)

    Zhu, Shuaibing; Zhou, Jin; Lu, Jun-an

    2018-04-01

    In this paper, we study the problem of identifying the partial topology of complex dynamical networks via a pinning mechanism. By using the network synchronization theory and the adaptive feedback controlling method, we propose a method which can greatly reduce the number of nodes and observers in the response network. Particularly, this method can also identify the whole topology of complex networks. A theorem is established rigorously, from which some corollaries are also derived in order to make our method more cost-effective. Several numerical examples are provided to verify the effectiveness of the proposed method. In the simulation, an approach is also given to avoid possible identification failure caused by inner synchronization of the drive network.

  13. 26 CFR 301.7701-12 - Employer identification number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Employer identification number. 301.7701-12 Section 301.7701-12 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Definitions § 301.7701-12 Employer identification...

  14. 78 FR 26244 - Updating of Employer Identification Numbers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... (including updated application information regarding the name and taxpayer identifying number of the... require these persons to update application information regarding the name and taxpayer identifying number..., Application for Employer Identification Number, requires entities to disclose the name of the EIN applicant's...

  15. Nuclear fuel pin scanner

    DOEpatents

    Bramblett, Richard L.; Preskitt, Charles A.

    1987-03-03

    Systems and methods for inspection of nuclear fuel pins to determine fiss loading and uniformity. The system includes infeed mechanisms which stockpile, identify and install nuclear fuel pins into an irradiator. The irradiator provides extended activation times using an approximately cylindrical arrangement of numerous fuel pins. The fuel pins can be arranged in a magazine which is rotated about a longitudinal axis of rotation. A source of activating radiation is positioned equidistant from the fuel pins along the longitudinal axis of rotation. The source of activating radiation is preferably oscillated along the axis to uniformly activate the fuel pins. A detector is provided downstream of the irradiator. The detector uses a plurality of detector elements arranged in an axial array. Each detector element inspects a segment of the fuel pin. The activated fuel pin being inspected in the detector is oscillated repeatedly over a distance equal to the spacing between adjacent detector elements, thereby multiplying the effective time available for detecting radiation emissions from the activated fuel pin.

  16. Potential of pin-by-pin SPN calculations as an industrial reference

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fliscounakis, M.; Girardi, E.; Courau, T.

    2012-07-01

    This paper aims at analysing the potential of pin-by-pin SP{sub n} calculations to compute the neutronic flux in PWR cores as an alternative to the diffusion approximation. As far as pin-by-pin calculations are concerned, a SPH equivalence is used to preserve the reactions rates. The use of SPH equivalence is a common practice in core diffusion calculations. In this paper, a methodology to generalize the equivalence procedure in the SP{sub n} equations context is presented. In order to verify and validate the equivalence procedure, SP{sub n} calculations are compared to 2D transport reference results obtained with the APOLL02 code. Themore » validation cases consist in 3x3 analytical assembly color sets involving burn-up heterogeneities, UOX/MOX interfaces, and control rods. Considering various energy discretizations (up to 26 groups) and flux development orders (up to 7) for the SP{sub n} equations, results show that 26-group SP{sub 3} calculations are very close to the transport reference (with pin production rates discrepancies < 1%). This proves the high interest of pin-by-pin SP{sub n} calculations as an industrial reference when relying on 26 energy groups combined with SP{sub 3} flux development order. Additionally, the SP{sub n} results are compared to diffusion pin-by-pin calculations, in order to evaluate the potential benefit of using a SP{sub n} solver as an alternative to diffusion. Discrepancies on pin-production rates are less than 1.6% for 6-group SP{sub 3} calculations against 3.2% for 2-group diffusion calculations. This shows that SP{sub n} solvers may be considered as an alternative to multigroup diffusion. (authors)« less

  17. Pin care

    MedlinePlus

    ... an infection, call your surgeon right away. Cleaning Supplies There are different types of pin-cleaning solutions. ... peroxide Use the solution that your surgeon recommends. Supplies you will need to clean your pin site ...

  18. 78 FR 913 - IRS Truncated Taxpayer Identification Numbers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ... taxpayer identification number, a TTIN. As an alternative to using a social security number (SSN), IRS... concerns about the risk of identity theft stemming from the inclusion of a taxpayer identifying number on a...) authorizes the Secretary to prescribe regulations with respect to the inclusion in returns, statements, or...

  19. Pinning Susceptibility at the Jamming Transition

    NASA Astrophysics Data System (ADS)

    Graves, Amy; Padgett, Elliot; Goodrich, Carl; Liu, Andrea

    2013-03-01

    Jamming in the presence of fixed or pinned obstacles, representing quenched disorder, is a situation of both practical and theoretical interest. We study the jamming of soft, bidisperse discs in which a subset of discs are pinned while the remaining particles equilibrate around them at a given volume fraction. The obstacles provide a supporting structure for the jammed configuration which not only lowers the jamming threshold, ϕJ, but affects the coordination number and other parameters of interest as the critical point is approached. In the limit of low obstacle density, one can calculate a pinning susceptibility χP, analogous to the magnetic susceptibility, with obstacle density playing the role of the magnetic field. The pinning susceptibility is thus expected to diverge in the thermodynamic limit as χP ~| ϕ -ϕJ | -γP . Finite-size scaling calculations allow us to confirm this and calculate the critical exponent, γP. Acknowledgement is made to the Donors of the Petrolium Research Fund administered by the American Chemical Society, Swarthmore College's Eugene M. Lang Faculty Fellowship, NSF grant DMR-1062638 and DOE grant DE-FG02-05ER46199.

  20. 33 CFR 181.27 - Information displayed near hull identification number.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Information displayed near hull... displayed near hull identification number. With the exception of the characters “US-”, which constitute the... the 12-character hull identification number (HIN), that information must be separated from the HIN by...

  1. Identification of serial number on bank card using recurrent neural network

    NASA Astrophysics Data System (ADS)

    Liu, Li; Huang, Linlin; Xue, Jian

    2018-04-01

    Identification of serial number on bank card has many applications. Due to the different number printing mode, complex background, distortion in shape, etc., it is quite challenging to achieve high identification accuracy. In this paper, we propose a method using Normalization-Cooperated Gradient Feature (NCGF) and Recurrent Neural Network (RNN) based on Long Short-Term Memory (LSTM) for serial number identification. The NCGF maps the gradient direction elements of original image to direction planes such that the RNN with direction planes as input can recognize numbers more accurately. Taking the advantages of NCGF and RNN, we get 90%digit string recognition accuracy.

  2. 48 CFR 1652.204-73 - Taxpayer Identification Number.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Identification Number (TIN), as used in this provision, means the number required by the Internal Revenue Service... information will result in payment being withheld until the TIN number is provided. (c) The Government may use the TIN to collect and report on any delinquent amounts arising out of the Carrier's relationship with...

  3. 48 CFR 1652.204-73 - Taxpayer Identification Number.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Identification Number (TIN), as used in this provision, means the number required by the Internal Revenue Service... information will result in payment being withheld until the TIN number is provided. (c) The Government may use the TIN to collect and report on any delinquent amounts arising out of the Carrier's relationship with...

  4. 48 CFR 1652.204-73 - Taxpayer Identification Number.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Identification Number (TIN), as used in this provision, means the number required by the Internal Revenue Service... information will result in payment being withheld until the TIN number is provided. (c) The Government may use the TIN to collect and report on any delinquent amounts arising out of the Carrier's relationship with...

  5. 48 CFR 1652.204-73 - Taxpayer Identification Number.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Identification Number (TIN), as used in this provision, means the number required by the Internal Revenue Service... information will result in payment being withheld until the TIN number is provided. (c) The Government may use the TIN to collect and report on any delinquent amounts arising out of the Carrier's relationship with...

  6. 48 CFR 1652.204-73 - Taxpayer Identification Number.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Identification Number (TIN), as used in this provision, means the number required by the Internal Revenue Service... information will result in payment being withheld until the TIN number is provided. (c) The Government may use the TIN to collect and report on any delinquent amounts arising out of the Carrier's relationship with...

  7. Proposing national identification number on dental prostheses as universal personal identification code - A revolution in forensic odontology

    PubMed Central

    Baad, Rajendra K.; Belgaumi, Uzma; Vibhute, Nupura; Kadashetti, Vidya; Chandrappa, Pramod Redder; Gugwad, Sushma

    2015-01-01

    The proper identification of a decedent is not only important for humanitarian and emotional reasons, but also for legal and administrative purposes. During the reconstructive identification process, all necessary information is gathered from the unknown body of the victim and hence that an objective reconstructed profile can be established. Denture marking systems are being used in various situations, and a number of direct and indirect methods are reported. We propose that national identification numbers be incorporated in all removable and fixed prostheses, so as to adopt a single and definitive universal personal identification code with the aim of achieving a uniform, standardized, easy, and fast identification method worldwide for forensic identification. PMID:26005294

  8. PINS chemical identification software

    DOEpatents

    Caffrey, Augustine J.; Krebs, Kennth M.

    2004-09-14

    An apparatus and method for identifying a chemical compound. A neutron source delivers neutrons into the chemical compound. The nuclei of chemical elements constituting the chemical compound emit gamma rays upon interaction with the neutrons. The gamma rays are characteristic of the chemical elements constituting the chemical compound. A spectrum of the gamma rays is generated having a detection count and an energy scale. The energy scale is calibrated by comparing peaks in the spectrum to energies of pre-selected chemical elements in the spectrum. A least-squares fit completes the calibration. The chemical elements constituting the chemical compound can be readily determined, which then allows for identification of the chemical compound.

  9. Straight SU-8 pins

    NASA Astrophysics Data System (ADS)

    Safavieh, R.; Pla Roca, M.; Qasaimeh, M. A.; Mirzaei, M.; Juncker, D.

    2010-05-01

    SU-8 can be patterned with high resolution, is flexible and tough. These characteristics qualify SU-8 as a material for making spotting pins for printing DNA and protein microarrays, and it can potentially replace the commonly used silicon and steel pins that are expensive, brittle in the case of silicon and can damage the substrate during the printing process. SU-8, however, accumulates large internal stress during fabrication and, as a consequence, thin and long SU-8 structures bend and coil up, which precludes using it for long, freestanding structures such as pins. Here we introduce (i) a novel fabrication process that allows the making of 30 mm long, straight spotting pins that feature (ii) a new design and surface chemistry treatments for better capillary flow control and more homogeneous spotting. A key innovation for the fabrication is a post-processing annealing step with slow temperature ramping and mechanical clamping between two identical substrates to minimize stress buildup and render it symmetric, respectively, which together yield a straight SU-8 structure. SU-8 pins fabricated using this process are compliant and resilient and can buckle without damage during printing. The pins comprise a novel flow stop valve for accurate metering of fluids, and their surface was chemically patterned to render the outside of the pin hydrophobic while the inside of the slit is hydrophilic, and the slit thus spontaneously fills when dipped into a solution while preventing droplet attachment on the outside. A single SU-8 pin was used to print 1392 protein spots in one run. SU-8 pins are inexpensive, straightforward to fabricate, robust and may be used as disposable pins for microarray fabrication. These pins serve as an illustration of the potential application of ultralow stress SU-8 for making freestanding microfabricated polymer microstructures.

  10. 49 CFR Appendix D to Part 512 - Vehicle Identification Number Information

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Vehicle Identification Number Information D Appendix D to Part 512 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL.... 512, App. D Appendix D to Part 512—Vehicle Identification Number Information The Chief Counsel has...

  11. 48 CFR 1604.970 - Taxpayer Identification Number.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Taxpayer Identification Number. 1604.970 Section 1604.970 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Taxpayer...

  12. 48 CFR 1604.970 - Taxpayer Identification Number.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Taxpayer Identification Number. 1604.970 Section 1604.970 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Taxpayer...

  13. 48 CFR 1604.970 - Taxpayer Identification Number.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Taxpayer Identification Number. 1604.970 Section 1604.970 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Taxpayer...

  14. 48 CFR 1604.970 - Taxpayer Identification Number.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Taxpayer Identification Number. 1604.970 Section 1604.970 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Taxpayer...

  15. 48 CFR 1604.970 - Taxpayer Identification Number.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Taxpayer Identification Number. 1604.970 Section 1604.970 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Taxpayer...

  16. Statistics of dislocation pinning at localized obstacles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dutta, A.; Bhattacharya, M., E-mail: mishreyee@vecc.gov.in; Barat, P.

    2014-10-14

    Pinning of dislocations at nanosized obstacles like precipitates, voids, and bubbles is a crucial mechanism in the context of phenomena like hardening and creep. The interaction between such an obstacle and a dislocation is often studied at fundamental level by means of analytical tools, atomistic simulations, and finite element methods. Nevertheless, the information extracted from such studies cannot be utilized to its maximum extent on account of insufficient information about the underlying statistics of this process comprising a large number of dislocations and obstacles in a system. Here, we propose a new statistical approach, where the statistics of pinning ofmore » dislocations by idealized spherical obstacles is explored by taking into account the generalized size-distribution of the obstacles along with the dislocation density within a three-dimensional framework. Starting with a minimal set of material parameters, the framework employs the method of geometrical statistics with a few simple assumptions compatible with the real physical scenario. The application of this approach, in combination with the knowledge of fundamental dislocation-obstacle interactions, has successfully been demonstrated for dislocation pinning at nanovoids in neutron irradiated type 316-stainless steel in regard to the non-conservative motion of dislocations. An interesting phenomenon of transition from rare pinning to multiple pinning regimes with increasing irradiation temperature is revealed.« less

  17. Identification of Bodies by Unique Serial Numbers on Implanted Medical Devices.

    PubMed

    Blessing, Melissa M; Lin, Peter T

    2018-05-01

    Visual identification is the most common identification method used by medical examiners but is not always possible. Alternative methods include X-ray, fingerprint, or DNA comparison, but these methods require additional resources. Comparison of serial numbers on implanted medical devices is a rapid and definitive method of identification. To assess the practicality of using this method, we reviewed 608 consecutive forensic autopsies performed at a regional medical examiner office. Of these, 56 cases required an alternative method of identification due to decomposition (n = 35), gunshot wound (n = 9), blunt trauma (n = 6), or charring (n = 6). Of these 56 cases, eight (14.3%) were known to have an implanted medical device. Of these eight cases, five (63%) could be positively identified by comparing serial numbers. If an implanted medical device is known to be present, and medical records are available, identification by medical device serial number should be a first-line method. © 2017 American Academy of Forensic Sciences.

  18. 20 CFR 422.112 - Employer identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Employer identification numbers. 422.112 Section 422.112 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES General..., and domestic corporations which elect social security coverage for employees of foreign subsidiaries...

  19. 26 CFR 31.3406(j)-1 - Taxpayer Identification Number (TIN) matching program.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 15 2013-04-01 2013-04-01 false Taxpayer Identification Number (TIN) matching... Number (TIN) matching program. (a) The matching program. Under section 3406(i), the Commissioner has the authority to establish Taxpayer Identification Number (TIN) matching programs. The Commissioner may...

  20. 26 CFR 31.3406(j)-1 - Taxpayer Identification Number (TIN) matching program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Taxpayer Identification Number (TIN) matching... Number (TIN) matching program. (a) The matching program. Under section 3406(i), the Commissioner has the authority to establish Taxpayer Identification Number (TIN) matching programs. The Commissioner may...

  1. 26 CFR 31.3406(j)-1 - Taxpayer Identification Number (TIN) matching program.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 15 2012-04-01 2012-04-01 false Taxpayer Identification Number (TIN) matching... Number (TIN) matching program. (a) The matching program. Under section 3406(i), the Commissioner has the authority to establish Taxpayer Identification Number (TIN) matching programs. The Commissioner may...

  2. 26 CFR 31.3406(j)-1 - Taxpayer Identification Number (TIN) matching program.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 15 2014-04-01 2014-04-01 false Taxpayer Identification Number (TIN) matching... Number (TIN) matching program. (a) The matching program. Under section 3406(i), the Commissioner has the authority to establish Taxpayer Identification Number (TIN) matching programs. The Commissioner may...

  3. 26 CFR 31.3406(j)-1 - Taxpayer Identification Number (TIN) matching program.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Taxpayer Identification Number (TIN) matching... Number (TIN) matching program. (a) The matching program. Under section 3406(i), the Commissioner has the authority to establish Taxpayer Identification Number (TIN) matching programs. The Commissioner may...

  4. 48 CFR 2152.204-70 - Taxpayer Identification Number.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... basis, and of which the Contractor is a member. Taxpayer Identification Number (TIN), as used in this... reporting income tax and other returns. The TIN is the Contractor's Social Security Number. (b) The... information will result in payment being withheld until the TIN is provided. (c) The Government may use the...

  5. 48 CFR 2152.204-70 - Taxpayer Identification Number.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... basis, and of which the Contractor is a member. Taxpayer Identification Number (TIN), as used in this... reporting income tax and other returns. The TIN is the Contractor's Social Security Number. (b) The... information will result in payment being withheld until the TIN is provided. (c) The Government may use the...

  6. 48 CFR 2152.204-70 - Taxpayer Identification Number.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... basis, and of which the Contractor is a member. Taxpayer Identification Number (TIN), as used in this... reporting income tax and other returns. The TIN is the Contractor's Social Security Number. (b) The... information will result in payment being withheld until the TIN is provided. (c) The Government may use the...

  7. 48 CFR 2152.204-70 - Taxpayer Identification Number.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... basis, and of which the Contractor is a member. Taxpayer Identification Number (TIN), as used in this... reporting income tax and other returns. The TIN is the Contractor's Social Security Number. (b) The... information will result in payment being withheld until the TIN is provided. (c) The Government may use the...

  8. 48 CFR 2152.204-70 - Taxpayer Identification Number.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... basis, and of which the Contractor is a member. Taxpayer Identification Number (TIN), as used in this... reporting income tax and other returns. The TIN is the Contractor's Social Security Number. (b) The... information will result in payment being withheld until the TIN is provided. (c) The Government may use the...

  9. Identification and characterization of pin and thrum alleles of two genes that co-segregate with the Primula S locus.

    PubMed

    Li, Jinhong; Webster, Margaret; Furuya, Masaki; Gilmartin, Philip M

    2007-07-01

    The study of heteromorphy in Primula over the past 140 years has established the reproductive significance of this breeding system. Plants produce either thrum or pin flowers that demonstrate reciprocal herkogamy. Thrums have short styles and produce large pollen from anthers at the mouth of the flower; pins have long styles and produce small pollen from anthers located within the corolla tube. The control of heteromorphy is orchestrated by the S locus with dominant (S) and recessive (s) alleles that comprise a co-adapted linkage group of genes. Thrum plants are heterozygous (Ss) and pin plants are homozygous (ss). Reciprocal crosses between the two forms are required for fertilization; within-morph crosses are impeded by a sporophytic self-incompatibility system. Rare recombination events within the S locus produce self-fertile homostyles. As a first step towards identifying genes located at the S locus, we used fluorescent differential display to screen for differential gene expression in pin and thrum flowers. Rather than only detecting differentially regulated genes, we identified two S locus linked genes by virtue of allelic variation between pin and thrum transcripts. Analysis of pin and thrum plants together with homostyle recombinant reveals that one gene flanks the locus, whereas the other shows complete linkage. One gene is related to Arabidopsis flower-timing genes Col9 and Col10; the other encodes a small predicted membrane protein of unknown function. Notwithstanding the diallelic behaviour of the Primula S locus, analysis of pin and thrum plants reveal three alleles for each gene: two pin and one thrum.

  10. Spring loaded locator pin assembly

    DOEpatents

    Groll, Todd A.; White, James P.

    1998-01-01

    This invention deals with spring loaded locator pins. Locator pins are sometimes referred to as captured pins. This is a mechanism which locks two items together with the pin that is spring loaded so that it drops into a locator hole on the work piece.

  11. Spring loaded locator pin assembly

    DOEpatents

    Groll, T.A.; White, J.P.

    1998-03-03

    This invention deals with spring loaded locator pins. Locator pins are sometimes referred to as captured pins. This is a mechanism which locks two items together with the pin that is spring loaded so that it drops into a locator hole on the work piece. 5 figs.

  12. Pin-Ching Maness | NREL

    Science.gov Websites

    Pin-Ching Maness Photo of Pin-Ching Maness Pin-Ching Maness Group Research Manager III-Molecular University, 1974 Professional Experience Principal Group Manager, Photobiology Group, National Renewable in Rubrivivax gelatinosus," PLOS ONE (2014) Illustration of a model of carbon monoxide and

  13. On pins and needles: how vaccines are portrayed on Pinterest.

    PubMed

    Guidry, Jeanine P D; Carlyle, Kellie; Messner, Marcus; Jin, Yan

    2015-09-22

    Vaccination is an effective public health tool for reducing morbidity and mortality caused by infectious diseases. However, increasing numbers of parents question the safety of vaccines or refuse to vaccinate their children outright. The Internet is playing a significant role in the growing voice of the anti-vaccination movement as a growing number of people use the Internet to obtain health information, including information about vaccines. Given the role the Internet plays in providing vaccination-related communication, coupled with limited research in this area, this study focused on the social media platform Pinterest, analyzing 800 vaccine-related pins through a quantitative content analysis. The majority of the pins were anti-vaccine, and most were original posts as opposed to repins. Concerns about vaccine safety and side effects were oft-repeated themes, as was the concept of conspiracy theory. Pro-vaccine pins elicited consistently more engagement than anti-vaccine pins. Health educators and public health organizations should be aware of these dynamics, since a successful health communication campaign should start with an understanding of what and how publics communicate about the topic at hand. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Pinning, flux diodes and ratchets for vortices interacting with conformal pinning arrays

    DOE PAGES

    Olson Reichhardt, C. J.; Wang, Y. L.; Xiao, Z. L.; ...

    2016-05-31

    A conformal pinning array can be created by conformally transforming a uniform triangular pinning lattice to produce a new structure in which the six-fold ordering of the original lattice is conserved but where there is a spatial gradient in the density of pinning sites. Here we examine several aspects of vortices interacting with conformal pinning arrays and how they can be used to create a flux flow diode effect for driving vortices in different directions across the arrays. Under the application of an ac drive, a pronounced vortex ratchet effect occurs where the vortices flow in the easy direction ofmore » the array asymmetry. When the ac drive is applied perpendicular to the asymmetry direction of the array, it is possible to realize a transverse vortex ratchet effect where there is a generation of a dc flow of vortices perpendicular to the ac drive due to the creation of a noise correlation ratchet by the plastic motion of the vortices. We also examine vortex transport in experiments and compare the pinning effectiveness of conformal arrays to uniform triangular pinning arrays. In conclusion, we find that a triangular array generally pins the vortices more effectively at the first matching field and below, while the conformal array is more effective at higher fields where interstitial vortex flow occurs.« less

  15. 27 CFR 479.35 - Employer identification number.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Employer identification number. 479.35 Section 479.35 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  16. 27 CFR 479.35 - Employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Employer identification number. 479.35 Section 479.35 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  17. 27 CFR 479.35 - Employer identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Employer identification number. 479.35 Section 479.35 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  18. 27 CFR 479.35 - Employer identification number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Employer identification number. 479.35 Section 479.35 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  19. 27 CFR 479.35 - Employer identification number.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Employer identification number. 479.35 Section 479.35 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES...

  20. A double tuned rail damper—increased damping at the two first pinned-pinned frequencies

    NASA Astrophysics Data System (ADS)

    Maes, J.; Sol, H.

    2003-10-01

    Railway-induced vibrations are a growing matter of environmental concern. The rapid development of transportation, the increase of vehicle speeds and vehicle weights have resulted in higher vibration levels. In the meantime vibrations that were tolerated in the past are now considered to be a nuisance. Numerous solutions have been proposed to remedy these problems. The majority only acts on a specific part of the dynamic behaviour of the track. This paper presents a possible solution to reduce the noise generated by the 'pinned-pinned' frequencies. Pinned-pinned frequencies correspond with standing waves whose nodes are positioned exactly at the sleeper supports. The two first pinned-pinned frequencies are situated approximately at 950 and 2200 Hz (UIC60-rail and sleeper spacing of 0.60 m). To attenuate these vibrations, the Department of MEMC at the VUB has developed a dynamic vibration absorber called the Double Tuned Rail Damper (DTRD). The DTRD is mounted between two sleepers on the rail and is powered by the motion of the rail. The DTRD consists of two major parts: a steel plate which is connected to the rail with an interface of an elastic layer, and a rubber mass. The two first resonance frequencies of the steel plate coincide with the targeted pinned-pinned frequencies of the rail. The rubber mass acts as a motion controller and energy absorber. Measurements at a test track of the French railway company (SNCF) have shown considerable attenuation of the envisaged pinned-pinned frequencies. The attenuation rate surpasses 5 dB/m at certain frequency bands.

  1. 24 CFR 232.616 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 232.616 Section 232.616 Housing and Urban... Borrowers § 232.616 Disclosure and verification of Social Security and Employer Identification Numbers. To... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  2. 24 CFR 232.616 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 232.616 Section 232.616 Housing and Urban... Borrowers § 232.616 Disclosure and verification of Social Security and Employer Identification Numbers. To... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  3. 24 CFR 232.616 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 232.616 Section 232.616 Housing and Urban... Borrowers § 232.616 Disclosure and verification of Social Security and Employer Identification Numbers. To... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  4. 24 CFR 232.616 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 232.616 Section 232.616 Housing and Urban... Borrowers § 232.616 Disclosure and verification of Social Security and Employer Identification Numbers. To... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  5. 24 CFR 232.616 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 232.616 Section 232.616 Housing and Urban... Borrowers § 232.616 Disclosure and verification of Social Security and Employer Identification Numbers. To... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  6. 16 CFR 300.4 - Registered identification numbers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Registered identification numbers. 300.4 Section 300.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.4 Registered...

  7. Synthesis and Pin1 inhibitory activity of thiazole derivatives.

    PubMed

    Zhao, Hailong; Cui, Guonan; Jin, Jing; Chen, Xiaoguang; Xu, Bailing

    2016-11-15

    Pin1 (Protein interacting with NIMA1) is a peptidyl prolyl cis-trans isomerase (PPIase) which specifically catalyze the conformational conversion of the amide bond of pSer/Thr-Pro motifs in its substrate proteins and is a novel promising anticancer target. A series of new thiazole derivatives were designed and synthesized, and their inhibitory activities were measured against human Pin1 using a protease-coupled enzyme assay. Of all the tested compounds, a number of thiazole derivatives bearing an oxalic acid group at 4-position were found to be potent Pin1 inhibitors with IC 50 values at low micromolar level. The detailed structure-activity relationships were analyzed and the binding features of compound 10b (IC 50 5.38μM) was predicted using CDOCKER program. The results of this research would provide informative guidance for further optimizing thiazole derivatives as potent Pin1 inhibitors. Copyright © 2016. Published by Elsevier Ltd.

  8. Robust pinning control of heterogeneous complex networks with jointly connected topologies and time-varying parametric uncertainty

    NASA Astrophysics Data System (ADS)

    Manfredi, Sabato

    2018-05-01

    The pinning/leader control problems provide the design of the leader or pinning controller in order to guide a complex network to a desired trajectory or target (synchronisation or consensus). Let a time-invariant complex network, pinning/leader control problems include the design of the leader or pinning controller gain and number of nodes to pin in order to guide a network to a desired trajectory (synchronization or consensus). Usually, lower is the number of pinned nodes larger is the pinning gain required to assess network synchronisation. On the other side, realistic application scenario of complex networks is characterised by switching topologies, time-varying node coupling strength and link weight that make hard to solve the pinning/leader control problem. Additionally, the system dynamics at nodes can be heterogeneous. In this paper, we derive robust stabilisation conditions of time-varying heterogeneous complex networks with jointly connected topologies when coupling strength and link weight interactions are affected by time-varying uncertainties. By employing Lyapunov stability theory and linear matrix inequality (LMI) technique, we formulate low computationally demanding stabilisability conditions to design a pinning/leader control gain for robust network synchronisation. The effectiveness of the proposed approach is shown by several design examples applied to a paradigmatic well-known complex network composed of heterogeneous Chua's circuits.

  9. 27 CFR 25.168 - Employer identification number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Employer identification number. 25.168 Section 25.168 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax Returns...

  10. 27 CFR 25.168 - Employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Employer identification number. 25.168 Section 25.168 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax Returns...

  11. 27 CFR 25.168 - Employer identification number.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Employer identification number. 25.168 Section 25.168 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Preparation and Remittance of Tax Returns...

  12. 27 CFR 25.168 - Employer identification number.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Employer identification number. 25.168 Section 25.168 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Preparation and Remittance of Tax Returns...

  13. 27 CFR 25.168 - Employer identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Employer identification number. 25.168 Section 25.168 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax Returns...

  14. 21 CFR 801.57 - Discontinuation of legacy FDA identification numbers assigned to devices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Discontinuation of legacy FDA identification... Device Identification § 801.57 Discontinuation of legacy FDA identification numbers assigned to devices... been assigned an FDA labeler code to facilitate use of NHRIC or NDC numbers may continue to use that...

  15. Shock characterization of toad pins

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weirick, L.J.; Navarro, M.J.

    1996-05-01

    The purpose of this program was to characterize Time Of Arrival Detectors (TOAD) pins response to shock loading with respect to risetime, amplitude, repeatability and consistency. TOAD pins were subjected to impacts of 35 to 420 kilobars amplitude and approximately 1 ms pulse width to investigate the timing spread of four pins and the voltage output profile of the individual pins. Sets of pins were also aged at 45{degree}, 60{degree} and 80{degree}C for approximately nine weeks before shock testing at 315 kilobars impact stress. Four sets of pins were heated to 50.2{degree}C (125{degree}F) for approximately two hours and then impactedmore » at either 50 or 315 kilobars. Also, four sets of pins were aged at 60{degree}C for nine weeks and then heated to 50.2{degree}C before shock testing at 50 and 315 kilobars impact stress, respectively. Particle velocity measurements at the contact point between the stainless steel targets and TOAD pins were made using a Velocity Interferometer System for Any Reflector (VISAR) to monitor both the amplitude and profile of the shock waves. {copyright} {ital 1996 American Institute of Physics.}« less

  16. Shock characterization of TOAD pins

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weirick, L.J.; Navarro, N.J.

    1995-08-01

    The purpose of this program was to characterize Time Of Arrival Detectors (TOAD) pins response to shock loading with respect to risetime, amplitude, repeatability and consistency. TOAD pins were subjected to impacts of 35 to 420 kilobars amplitude and approximately 1 ms pulse width to investigate the timing spread of four pins and the voltage output profile of the individual pins. Sets of pins were also aged at 45{degrees}, 60{degrees}, and 80{degrees}C for approximately nine weeks before shock testing at 315 kilobars impact stress. Four sets of pins were heated to 50.2{degrees}C (125{degrees}F) for approximately two hours and then impactedmore » at either 50 or 315 kilobars. Also, four sets of pins were aged at 60{degrees}C for nine weeks and then heated to 50.2{degrees}C before shock testing at 50 and 315 kilobars impact stress, respectively. Particle velocity measurements at the contact point between the stainless steel targets and TOAD pins were made using a Velocity Interferometer System for Any Reflector (VISAR) to monitor both the amplitude and profile of the shock waves.« less

  17. A physico-genetic module for the polarisation of auxin efflux carriers PIN-FORMED (PIN)

    NASA Astrophysics Data System (ADS)

    Hernández-Hernández, Valeria; Barrio, Rafael A.; Benítez, Mariana; Nakayama, Naomi; Romero-Arias, José Roberto; Villarreal, Carlos

    2018-05-01

    Intracellular polarisation of auxin efflux carriers is crucial for understanding how auxin gradients form in plants. The polarisation dynamics of auxin efflux carriers PIN-FORMED (PIN) depends on both biomechanical forces as well as chemical, molecular and genetic factors. Biomechanical forces have shown to affect the localisation of PIN transporters to the plasma membrane. We propose a physico-genetic module of PIN polarisation that integrates biomechanical, molecular, and cellular processes as well as their non-linear interactions. The module was implemented as a discrete Boolean model and then approximated to a continuous dynamic system, in order to explore the relative contribution of the factors mediating PIN polarisation at the scale of single cell. Our models recovered qualitative behaviours that have been experimentally observed and enable us to predict that, in the context of PIN polarisation, the effects of the mechanical forces can predominate over the activity of molecular factors such as the GTPase ROP6 and the ROP-INTERACTIVE CRIB MOTIF-CONTAINING PROTEIN RIC1.

  18. Foolproof quick-release locking pin

    NASA Technical Reports Server (NTRS)

    Nelson, E. P.; Othman, T. E.; Zmuda, L. J.

    1970-01-01

    Locking pin can be withdrawn only when stress on the joint is negligible. Pin consists of a forward-pointing sleeve, a spring-loaded sliding handle, and a sliding plunger. Plunger movement controls installation and withdrawal of pin.

  19. The PIN gene family in cotton (Gossypium hirsutum): genome-wide identification and gene expression analyses during root development and abiotic stress responses.

    PubMed

    He, Peng; Zhao, Peng; Wang, Limin; Zhang, Yuzhou; Wang, Xiaosi; Xiao, Hui; Yu, Jianing; Xiao, Guanghui

    2017-07-03

    Cell elongation and expansion are significant contributors to plant growth and morphogenesis, and are often regulated by environmental cues and endogenous hormones. Auxin is one of the most important phytohormones involved in the regulation of plant growth and development and plays key roles in plant cell expansion and elongation. Cotton fiber cells are a model system for studying cell elongation due to their large size. Cotton is also the world's most utilized crop for the production of natural fibers for textile and garment industries, and targeted expression of the IAA biosynthetic gene iaaM increased cotton fiber initiation. Polar auxin transport, mediated by PIN and AUX/LAX proteins, plays a central role in the control of auxin distribution. However, very limited information about PIN-FORMED (PIN) efflux carriers in cotton is known. In this study, 17 PIN-FORMED (PIN) efflux carrier family members were identified in the Gossypium hirsutum (G. hirsutum) genome. We found that PIN1-3 and PIN2 genes originated from the At subgenome were highly expressed in roots. Additionally, evaluation of gene expression patterns indicated that PIN genes are differentially induced by various abiotic stresses. Furthermore, we found that the majority of cotton PIN genes contained auxin (AuxREs) and salicylic acid (SA) responsive elements in their promoter regions were significantly up-regulated by exogenous hormone treatment. Our results provide a comprehensive analysis of the PIN gene family in G. hirsutum, including phylogenetic relationships, chromosomal locations, and gene expression and gene duplication analyses. This study sheds light on the precise roles of PIN genes in cotton root development and in adaption to stress responses.

  20. New types of high field pinning centers and pinning centers for the peak effect

    NASA Astrophysics Data System (ADS)

    Gajda, Daniel; Zaleski, Andrzej; Morawski, Andrzej; Hossain, Md Shahriar A.

    2017-08-01

    In this article, we report the results of a study that shows the existence of pinning centers inside grains and between grains in NbTi wires. We accurately show the ranges of magnetic fields in which the individual pinning centers operate. The pinning centers inside grains are activated in high magnetic fields above 6 T. We show the range of magnetic fields in which individual defects, dislocations, precipitates inside grains and substitutions in the crystal lattice can operate. We show the existence of a new kind of high field pinning center, which operates in high magnetic fields from 8 to ˜9.5 T. We indicate that dislocations create pinning centers in the range of magnetic fields from 6 to 8 T. In addition, our measurements suggest that the peak effect (increased critical current density (J c) near the upper critical field (B c2)) could be attributed to martensitic (needle-shaped) α‧-Ti inclusions inside grains. These centers are very important because they work very effectively in magnetic fields above 9.5-10 T. We also show that the α-Ti precipitates (between grains) with a thickness similar to the coherence length create pinning centers which work very effectively in magnetic fields from 3 to 6 T. In magnetic fields below 3 T, they act very efficiently in grain boundaries. The measurements indicate that the pinning centers created by dislocations only can be tested by transport measurements. This indicates that dislocations do not increase the magnetic critical current density (J cm). Cold drawing improves pinning centers at grain boundaries and increases the dislocation density, and cold-drawing pinning centers are responsible for the peak effect.

  1. Fuel pin

    DOEpatents

    Christiansen, D.W.; Karnesky, R.A.; Leggett, R.D.; Baker, R.B.

    1987-11-24

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  2. Fuel pin

    DOEpatents

    Christiansen, David W.; Karnesky, Richard A.; Leggett, Robert D.; Baker, Ronald B.

    1989-10-03

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  3. Fuel pin

    DOEpatents

    Christiansen, David W.; Karnesky, Richard A.; Leggett, Robert D.; Baker, Ronald B.

    1989-01-01

    A fuel pin for a liquid metal nuclear reactor is provided. The fuel pin includes a generally cylindrical cladding member with metallic fuel material disposed therein. At least a portion of the fuel material extends radially outwardly to the inner diameter of the cladding member to promote efficient transfer of heat to the reactor coolant system. The fuel material defines at least one void space therein to facilitate swelling of the fuel material during fission.

  4. 24 CFR 5.216 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 5.216 Section 5.216 Housing and Urban Development...; WAIVERS Disclosure and Verification of Social Security Numbers and Employer Identification Numbers; Procedures for Obtaining Income Information Disclosure and Verification of Social Security Numbers and...

  5. 24 CFR 5.216 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 5.216 Section 5.216 Housing and Urban Development...; WAIVERS Disclosure and Verification of Social Security Numbers and Employer Identification Numbers; Procedures for Obtaining Income Information Disclosure and Verification of Social Security Numbers and...

  6. 24 CFR 5.216 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 5.216 Section 5.216 Housing and Urban Development...; WAIVERS Disclosure and Verification of Social Security Numbers and Employer Identification Numbers; Procedures for Obtaining Income Information Disclosure and Verification of Social Security Numbers and...

  7. 24 CFR 5.216 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 5.216 Section 5.216 Housing and Urban Development...; WAIVERS Disclosure and Verification of Social Security Numbers and Employer Identification Numbers; Procedures for Obtaining Income Information Disclosure and Verification of Social Security Numbers and...

  8. 24 CFR 5.216 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 5.216 Section 5.216 Housing and Urban Development...; WAIVERS Disclosure and Verification of Social Security Numbers and Employer Identification Numbers; Procedures for Obtaining Income Information Disclosure and Verification of Social Security Numbers and...

  9. 33 CFR 187.321 - What are the hull identification number (HIN) provisions?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What are the hull identification number (HIN) provisions? 187.321 Section 187.321 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... Vessel Titling Systems § 187.321 What are the hull identification number (HIN) provisions? A State must...

  10. Pinning transition in shrinking nanobubbles

    NASA Astrophysics Data System (ADS)

    Tan, Beng Hau; An, Hongjie; Ohl, Claus-Dieter

    Surface nanobubbles are unusually long-lived gaseous domains that form on immersed substrates. Although liquid droplets are known to grow or shrink in either an unpinned (constant contact angle) or a pinned (constant footprint radius) mode, surface nanobubbles have only ever been observed in the pinned state. Theory suggests that, provided the nanobubbles are sustained by supersaturated liquid, they are indefinitely stable in the pinned mode, but rapidly dissolve into bulk liquid if not. Yet many basic aspects of the line pinning are not yet clarified, such as its magnitude or the conditions in which it becomes dominant. In this talk we present experiments with total internal fluorescence microscopy in which nanobubbles nucleated with a temperature difference method initially shrink in an unpinned mode, before transitioning to a pinned state. Using a simple energy balance we recover an estimate for the pinning force on each nanobubble.

  11. 49 CFR 172.332 - Identification number markings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 160 mm (6.3 inches) high by 400 mm (15.7 inches) wide with a 15 mm (0.6 inches) black outer border. The identification number shall be displayed in 100 mm (3.9 inches) black Helvetica Medium numerals on the orange panel. Measurements may vary from those specified plus or minus 5 mm (0.2 inches). (2) The...

  12. 49 CFR 172.332 - Identification number markings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 160 mm (6.3 inches) high by 400 mm (15.7 inches) wide with a 15 mm (0.6 inches) black outer border. The identification number shall be displayed in 100 mm (3.9 inches) black Helvetica Medium numerals on the orange panel. Measurements may vary from those specified plus or minus 5 mm (0.2 inches). (2) The...

  13. Nondestrucive analysis of fuel pins

    DOEpatents

    Stepan, I.E.; Allard, N.P.; Suter, C.R.

    1972-11-03

    Disclosure is made of a method and a correspondingly adapted facility for the nondestructive analysis of the concentation of fuel and poison in a nuclear reactor fuel pin. The concentrations of fuel and poison in successive sections along the entire length of the fuel pin are determined by measuring the reactivity of a thermal reactor as each successive small section of the fuel pin is exposed to the neutron flux of the reactor core and comparing the measured reactivity with the reactivities measured for standard fuel pins having various known concentrations. Only a small section of the length of the fuel pin is exposed to the neutron flux at any one time while the remainder of the fuel pin is shielded from the neutron flux. In order to expose only a small section at any one time, a boron-10-lined dry traverse tube is passed through the test region within the core of a low-power thermal nuclear reactor which has a very high fuel sensitivity. A narrow window in the boron-10 lining is positioned at the core center line. The fuel pins are then systematically traversed through the tube past the narrow window such that successive small sections along the length of the fuel pin are exposed to the neutron flux which passes through the narrow window.

  14. 24 CFR 201.6 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 201.6 Section 201.6 Housing and Urban Development... HOME LOANS General § 201.6 Disclosure and verification of Social Security and Employer Identification... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  15. 24 CFR 201.6 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 201.6 Section 201.6 Housing and Urban Development... HOME LOANS General § 201.6 Disclosure and verification of Social Security and Employer Identification... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  16. 24 CFR 201.6 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 201.6 Section 201.6 Housing and Urban Development... HOME LOANS General § 201.6 Disclosure and verification of Social Security and Employer Identification... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  17. 24 CFR 201.6 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 201.6 Section 201.6 Housing and Urban Development... HOME LOANS General § 201.6 Disclosure and verification of Social Security and Employer Identification... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  18. 24 CFR 201.6 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 201.6 Section 201.6 Housing and Urban Development... HOME LOANS General § 201.6 Disclosure and verification of Social Security and Employer Identification... the disclosure and verification of Social Security and Employer Identification Numbers, as provided by...

  19. The kinetics of root gravitropism in PIN mutants suggest redundancy in the signal transduction pathway

    NASA Astrophysics Data System (ADS)

    Wolverton, Chris

    As nonmotile organisms, plants rely on differential growth responses to maximize exposure to the resources necessary for growth and reproduction. One of the primary environmental cues causing differential growth in roots is gravity, which is thought to be sensed predominately in the root cap. This gravity perception event is thought to be transduced into information in the form of an auxin gradient across the cap and propagating basipetally toward the elongation zone. The discovery of several families of auxin efflux and influx carriers has provided significant insight into the mechanisms of directional auxin transport, and the identification of mutants in the genes encoding these carriers provides the opportunity to test the roles of these transporters in plant gravitropism. In this study, we report the results of a systematic, high-resolution study of the kinetics of root gravitropism of mutants in the PIN family of auxin efflux carriers. Based on reported expression and localization patterns, we predicted mutations in PIN2, PIN3, PIN4, and PIN7 to cause the greatest reduction in root gravitropism. While pin2 mutants showed severe gravitropic deficiencies in roots as reported previously, several alleles of pin3, pin4 and pin7 remained strongly gravitropic. PIN3 has been localized to the central columella cells, the purported gravisensing cells in the root, and shown to rapidly relocate to the lower flank of the columella cells upon gravistimulation, suggesting an early role in auxin gradient formation. Mutant alleles of PIN3 showed an early delay in response, with just 7 deg of curvature in the first hour compared to approximately 15 deg h-1 in wild-type, but their rate of curvature recovered to near wild-type levels over the ensuing 3 h. Pin3 mutants also showed a slower overall growth rate (124 µm h-1 ), elongating at approximately half the rate of wild-type roots (240 µm h-1 ). PIN4 has been localized to the quiescent center in the root, where it presumably

  20. Pip pin reliability and design

    NASA Technical Reports Server (NTRS)

    Skyles, Lane P.

    1994-01-01

    Pip pins are used in many engineering applications. Of particular interest to the aerospace industry is their use in various mechanism designs. Many payloads that fly aboard our nation's Space Shuttle have at least one actuated mechanism. Often these mechanisms incorporate pip pins in their design in order to fasten interfacing parts or joints. Pip pins are most often used when an astronaut will have a direct interface with the mechanism. This interfacing can be done during Space Shuttle mission EVA's (ExtraVehicular Activity). The main reason for incorporating pip pins is convenience and their ability to provide a quick release for interfacing parts. However, there are some issues that must be taken into account when using them in a design. These issues include documented failures and quality control problems when using substandard pip pins. A history of pip pins as they relate to the aerospace industry as well as general design features is discussed.

  1. Pin1 promotes transforming growth factor-beta-induced migration and invasion.

    PubMed

    Matsuura, Isao; Chiang, Keng-Nan; Lai, Chen-Yu; He, Dongming; Wang, Guannan; Ramkumar, Romila; Uchida, Takafumi; Ryo, Akihide; Lu, Kunping; Liu, Fang

    2010-01-15

    Transforming growth factor-beta (TGF-beta) regulates a wide variety of biological activities. It induces potent growth-inhibitory responses in normal cells but promotes migration and invasion of cancer cells. Smads mediate the TGF-beta responses. TGF-beta binding to the cell surface receptors leads to the phosphorylation of Smad2/3 in their C terminus as well as in the proline-rich linker region. The serine/threonine phosphorylation sites in the linker region are followed by the proline residue. Pin1, a peptidyl-prolyl cis/trans isomerase, recognizes phosphorylated serine/threonine-proline motifs. Here we show that Smad2/3 interacts with Pin1 in a TGF-beta-dependent manner. We further show that the phosphorylated threonine 179-proline motif in the Smad3 linker region is the major binding site for Pin1. Although epidermal growth factor also induces phosphorylation of threonine 179 and other residues in the Smad3 linker region the same as TGF-beta, Pin1 is unable to bind to the epidermal growth factor-stimulated Smad3. Further analysis suggests that phosphorylation of Smad3 in the C terminus is necessary for the interaction with Pin1. Depletion of Pin1 by small hairpin RNA does not significantly affect TGF-beta-induced growth-inhibitory responses and a number of TGF-beta/Smad target genes analyzed. In contrast, knockdown of Pin1 in human PC3 prostate cancer cells strongly inhibited TGF-beta-mediated migration and invasion. Accordingly, TGF-beta induction of N-cadherin, which plays an important role in migration and invasion, is markedly reduced when Pin1 is depleted in PC3 cells. Because Pin1 is overexpressed in many cancers, our findings highlight the importance of Pin1 in TGF-beta-induced migration and invasion of cancer cells.

  2. Pin-Retraction Mechanism On Quick-Release Cover

    NASA Technical Reports Server (NTRS)

    Macmartin, Malcolm

    1994-01-01

    Quick-release cover includes pin-retraction mechanism releasing cover quickly from lower of two sets of pin connections holding cover. Cover released at top by pulling lever as described in "Lever-Arm Pin Puller" (NPO-18788). Removal of cover begins when technician or robot pulls upper-pin-release lever. Cover swings downward until tabs on lower pins are pulled through slots in their receptacles. Lower pins are then free.

  3. Measurement strategy and analytic model to determine firing pin force

    NASA Astrophysics Data System (ADS)

    Lesenciuc, Ioan; Suciu, Cornel

    2016-12-01

    As illustrated in literature, ballistics is a branch of theoretical mechanics, which studies the construction and working principles of firearms and ammunition, their effects, as well as the motions of projectiles and bullets1. Criminalistics identification, as part of judiciary identification represents an activity aimed at finding common traits of different objects, objectives, phenomena and beings, but more importantly, traits that differentiate each of them from similar ones2-4. In judicial ballistics, in the case of rifled firearms it is relatively simple for experts to identify the used weapon from traces left on the projectile, as the rifling of the barrel leaves imprints on the bullet, which remain approximately identical even after the respective weapon is fired 100 times with the same barrel. However, in the case of smoothbore firearms, their identification becomes much more complicated. As the firing cap suffers alterations from being hit by the firing pin, determination of the force generated during impact creates the premises for determining the type of firearm used to shoot the respective cartridge. The present paper proposes a simple impact model that can be used to evaluate the force generated by the firing pin during its impact with the firing cap. The present research clearly showed that each rifle, by the combination of the three investigated parameters (impact force maximum value, its variation diagram, and impact time) leave a unique trace. Application of such a method in ballistics can create the perspectives for formulating clear conclusions that eliminate possible judicial errors in this field.

  4. Pin site care for preventing infections associated with external bone fixators and pins.

    PubMed

    Lethaby, Anne; Temple, Jenny; Santy-Tomlinson, Julie

    2013-12-03

    Metal pins are used to apply skeletal traction or external fixation devices in the management of orthopaedic fractures. These percutaneous pins protrude through the skin, and the way in which they are treated after insertion may affect the incidence of pin site infection. This review set out to summarise the evidence of pin site care on infection rates. To assess the effect on infection rates of different methods of cleansing and dressing orthopaedic percutaneous pin sites. In September 2013, for this third update, we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. We evaluated all randomised controlled trials (RCTs) that compared the effect on infection and other complication rates of different methods of cleansing or dressing orthopaedic percutaneous pin sites. Two review authors independently assessed the citations retrieved by the search strategies for reports of relevant RCTs, then independently selected trials that satisfied the inclusion criteria, extracted data and undertook quality assessment. A total of eleven trials (572 participants) were eligible for inclusion in the review but not all participants contributed data to each comparison. Three trials compared a cleansing regimen (saline, alcohol, hydrogen peroxide or antibacterial soap) with no cleansing (application of a dry dressing), three trials compared alternative sterile cleansing solutions (saline, alcohol, peroxide, povidone iodine), three trials compared methods of cleansing (one trial compared identical pin site care performed daily or weekly and the two others compared sterile with non sterile techniques), one trial compared daily pin site care with no care and six trials compared different dressings (using different solutions/ointments and dry and impregnated gauze or sponges). One small blinded

  5. The effects of pin elasticity, clearance, and friction on the stresses in a pin-loaded orthotropic plate

    NASA Technical Reports Server (NTRS)

    Hyer, M. W.; Klang, E. C.; Cooper, D. E.

    1987-01-01

    The effects of pin elasticity, clearance, and friction on the stresses in a pin loaded orthotropic plate are studied. The effects are studied by posing the problem as a planar contact elasticity problem, the pin and the plate being two elastic bodies which interact through contact. Coulomb friction is assumed, the pin loads the plate in one of its principal material directions, and the plate is infinite in extent. A collocation scheme and interaction, in conjunction with a complex variable series solution, are used to obtain numerical results. The contact region between the plate and pin is unknown and must be solved for as part of the solution. The same is true of the region of friction induced no slip. Two pin stiffnesses, two clearance levels, two friction levels and two laminates, a (0/+ or - 45/90)s and a (02/+ or - 45)s, are studied. The effects of pin elasticity, clearance, and friction on the load capacity of the plate are assessed by comparing the load capacity of the plate with the capacity when the pin is rigid, perfectly fitting, and frictionless.

  6. Alignment Pins for Assembling and Disassembling Structures

    NASA Technical Reports Server (NTRS)

    Campbell, Oliver C.

    2008-01-01

    Simple, easy-to-use, highly effective tooling has been devised for maintaining alignment of bolt holes in mating structures during assembly and disassembly of the structures. The tooling was originally used during removal of a body flap from the space shuttle Atlantis, in which misalignments during removal of the last few bolts could cause the bolts to bind in their holes. By suitably modifying the dimensions of the tooling components, the basic design of the tooling can readily be adapted to other structures that must be maintained in alignment. The tooling includes tapered, internally threaded alignment pins designed to fit in the bolt holes in one of the mating structures, plus a draw bolt and a cup that are used to install or remove each alignment pin. In preparation for disassembly of two mating structures, external supports are provided to prevent unintended movement of the structures. During disassembly of the structures, as each bolt that joins the structures is removed, an alignment pin is installed in its place. Once all the bolts have been removed and replaced with pins, the pins maintain alignment as the structures are gently pushed or pulled apart on the supports. In assembling the two structures, one reverses the procedure described above: pins are installed in the bolt holes, the structures are pulled or pushed together on the supports, then the pins are removed and replaced with bolts. The figure depicts the tooling and its use. To install an alignment pin in a bolt hole in a structural panel, the tapered end of the pin is inserted from one side of the panel, the cup is placed over the pin on the opposite side of the panel, the draw bolt is inserted through the cup and threaded into the pin, the draw bolt is tightened to pull the pin until the pin is seated firmly in the hole, then the draw bolt and cup are removed, leaving the pin in place. To remove an alignment pin, the cup is placed over the pin on the first-mentioned side of the panel, the draw

  7. Variation in pin knot frequency in black walnut lumber cut from a small provenance/progeny test

    Treesearch

    Peter Y. S. Chen; Robert E. Bodkin; J. W. Van Sambeek

    1995-01-01

    This small study examined the frequency of knots (> 1 growth ring), pin knots (latent or suppressed buds), and pin knot clusters in 414 black walnut (Juglans nigra L.) lumber from 42 logs. 18 to 21 cm dbh, cut from a 14-year-old provenance/progeny test. Two boards from opposite sides of each log were analyzed for number of knots, pin knots, and...

  8. Enhancement of the forced convective heat transfer on mini pin fin heat sinks with micro spiral fins

    NASA Astrophysics Data System (ADS)

    Khonsue, Osot

    2018-02-01

    This research is an experimental study on the characteristics of heat transfer and pressure drop in mini heat sinks using air as the working fluid. The experiments were performed under a constant heat flux ranging from 9.132-13.698 kW/m2 and the air Reynolds number range 322-1982. Three different types of mini heat sinks were rectangle pin fins, cylindrical pin fins, and spiral pin fins with 36x28x9 mm and 5 mm fins high. There were 63 fins altogether and all were made of aluminum. The results showed that the characteristics of the temperature of heat sink of spiral pin fins was the least. Meanwhile the average heat transfer coefficient and Nusselt number of spiral pin fins were the most . Regarding the pressure drop, the rectangular pin fins was the least. The results of this study can be used to guide the design and development of electronic devices cooling system with forced convective heat transfer for higher performance in the future.

  9. 24 CFR 242.68 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 242.68 Section 242.68 Housing and Urban Development... Requirements § 242.68 Disclosure and verification of Social Security and Employer Identification Numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of Social Security Numbers...

  10. 24 CFR 242.68 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 242.68 Section 242.68 Housing and Urban Development... Requirements § 242.68 Disclosure and verification of Social Security and Employer Identification Numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of Social Security Numbers...

  11. 24 CFR 242.68 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 242.68 Section 242.68 Housing and Urban Development... Requirements § 242.68 Disclosure and verification of Social Security and Employer Identification Numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of Social Security Numbers...

  12. 24 CFR 242.68 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 242.68 Section 242.68 Housing and Urban Development... Requirements § 242.68 Disclosure and verification of Social Security and Employer Identification Numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of Social Security Numbers...

  13. 24 CFR 242.68 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 242.68 Section 242.68 Housing and Urban Development... Requirements § 242.68 Disclosure and verification of Social Security and Employer Identification Numbers. The requirements set forth in 24 CFR part 5, regarding the disclosure and verification of Social Security Numbers...

  14. Nonequilibrium dynamic phases in driven vortex lattices with periodic pinning

    NASA Astrophysics Data System (ADS)

    Reichhardt, Charles Michael

    1998-12-01

    We present the results of an extensive series of simulations of flux-gradient and current driven vortices interacting with either random or periodically arranged pinning sites. First, we consider flux-gradient-driven simulations of superconducting vortices interacting with strong randomly-distributed columnar pinning defects, as an external field H(t) is quasi-statically swept from zero through a matching field Bsb{phi}. Here, we find significant changes in the behavior of the local flux density B(x, y, H(t)), magnetization M(H(t)), critical current Jsb{c}(B(t)), and the individual vortex flow paths, as the local flux density crosses Bsb{phi}. Further, we find that for a given pin density, Jsb{c}(B) can be enhanced by maximizing the distance between the pins for B < Bsb{phi}. For the case of periodic pinning sites as a function of applied field, we find a rich variety of ordered and partially-ordered vortex lattice configurations. We present formulas that predict the matching fields at which commensurate vortex configurations occur and the vortex lattice orientation with respect to the pinning lattice. Our results are in excellent agreement with recent imaging experiments on square pinning arrays (K. Harada et al., Science 274, 1167 (1996)). For current driven simulations with periodic pinning we find a remarkable number of dynamical plastic flow phases. Signatures of the transitions between these different dynamical phases include sudden jumps in the current-voltage curves, hysteresis, as well as marked changes in the vortex trajectories and vortex lattice order. These phases are outlined in a series of dynamic phase diagrams. We show that several of these phases and their phase-boundaries can be understood in terms of analytical arguments. Finally, when the vortex lattice is driven at varying angles with respect to the underlying periodic pinning array, the transverse voltage-current V(I) curves show a series of mode-locked plateaus with the overall V(I) forming

  15. 49 CFR 172.334 - Identification numbers; prohibited display.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... or 1.6, DANGEROUS, or subsidiary hazard placard. (b) No person may display an identification number on a placard, orange panel or white square-on-point display configuration unless— (1) The... the placard, orange panel or white square-on-point configuration authorized by § 172.332 or § 172.336...

  16. 49 CFR 172.334 - Identification numbers; prohibited display.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or 1.6, DANGEROUS, or subsidiary hazard placard. (b) No person may display an identification number on a placard, orange panel or white square-on-point display configuration unless— (1) The... the placard, orange panel or white square-on-point configuration authorized by § 172.332 or § 172.336...

  17. 49 CFR 172.334 - Identification numbers; prohibited display.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... or 1.6, DANGEROUS, or subsidiary hazard placard. (b) No person may display an identification number on a placard, orange panel or white square-on-point display configuration unless— (1) The... the placard, orange panel or white square-on-point configuration authorized by § 172.332 or § 172.336...

  18. 49 CFR 172.334 - Identification numbers; prohibited display.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... or 1.6, DANGEROUS, or subsidiary hazard placard. (b) No person may display an identification number on a placard, orange panel or white square-on-point display configuration unless— (1) The... the placard, orange panel or white square-on-point configuration authorized by § 172.332 or § 172.336...

  19. 49 CFR 172.334 - Identification numbers; prohibited display.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or 1.6, DANGEROUS, or subsidiary hazard placard. (b) No person may display an identification number on a placard, orange panel or white square-on-point display configuration unless— (1) The... the placard, orange panel or white square-on-point configuration authorized by § 172.332 or § 172.336...

  20. A review of recent theoretical and computational studies on pinned surface nanobubbles

    NASA Astrophysics Data System (ADS)

    Liu, Yawei; Zhang, Xianren

    2018-01-01

    The findings of long-lived surface nanobubbles in various experiments brought a puzzle in theory, as they were supposed to be dissolved in microseconds due to the high Laplace pressure. However, an increasing number of studies suggest that the pinning of contact line, together with certain levels of oversaturation, is responsible for the anomalous stability of surface nanobubble. This mechanism can interpret most characteristics of surface nanobubbles. Here we summarize recent theoretical and computational work to explain how the surface nanobubbles become stable with the pinning of contact line. Other related work devoted to understand the unusual behaviors of pinned surface nanobubbles are also reviewed here.

  1. Anvil for Flaring PCB Guide Pins

    NASA Technical Reports Server (NTRS)

    Winn, E.; Turner, R.

    1985-01-01

    Spring-loaded anvil results in fewer fractured pins. New anvil for flaring guide pins in printed-circuit boards absorbs approximately 80 percent of press force. As result fewer pins damaged, and work output of flaring press greatly increased.

  2. Performance measurements of hybrid PIN diode arrays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jernigan, J.G.; Arens, J.F.; Kramer, G.

    We report on the successful effort to develop hybrid PIN diode arrays and to demonstrate their potential as components of vertex detectors. Hybrid pixel arrays have been fabricated by the Hughes Aircraft Co. by bump bonding readout chips developed by Hughes to an array of PIN diodes manufactured by Micron Semiconductor Inc. These hybrid pixel arrays were constructed in two configurations. One array format having 10 {times} 64 pixels, each 120 {mu}m square, and the other format having 256 {times} 256 pixels, each 30 {mu}m square. In both cases, the thickness of the PIN diode layer is 300 {mu}m. Measurementsmore » of detector performance show that excellent position resolution can be achieved by interpolation. By determining the centroid of the charge cloud which spreads charge into a number of neighboring pixels, a spatial resolution of a few microns has been attained. The noise has been measured to be about 300 electrons (rms) at room temperature, as expected from KTC and dark current considerations, yielding a signal-to-noise ratio of about 100 for minimum ionizing particles. 4 refs., 13 figs.« less

  3. Aurora-A over-expression in high-grade PIN lesions and prostate cancer.

    PubMed

    Buschhorn, Holly McKlveen; Klein, Robert R; Chambers, Susan M; Hardy, Margaret C; Green, Sylvan; Bearss, David; Nagle, Raymond B

    2005-09-01

    Over-expression of Aurora-A (Aurora 2 kinase, STK-15), a protein found in centrosomes thought to be associated with genetic instability, has been previously documented in prostate cancer [Pihan et al.: Cancer Res 61(5):2212-2219, 2001]. It is unknown if this protein is also over-expressed in high-grade prostatic intraepithelial neoplasia (PIN) lesions. PIN lesions were examined for increased Aurora-A using immunohistochemical staining on archival paraffin embedded prostatectomy tissue. Aurora-A expression was scored using size, number, and staining intensity. Protein expression was examined and compared between stromal cells, normal glands, high-grade PIN lesions, and invasive cancer. Immunohistochemistry shows an increased expression of Aurora-A in 96% of high-grade PIN cases, and 98% in cancer lesions. Twenty-nine percent of cases of normal glands from cancerous prostates also showed increased Aurora-A expression. Over-expression of Aurora-A is present in some normal and the majority of high-grade PIN lesions indicating that this may be an early event that leads to the genetic instability seen in prostate carcinogenesis. Copyright 2005 Wiley-Liss, Inc.

  4. 49 CFR 172.336 - Identification numbers; special provisions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... accordance with § 172.542(c). (3) On cargo tanks They contain only fuel oil The cargo tank is marked “Fuel... petroleum distillate fuel The identification number for the liquid petroleum distillate fuel having the lowest flash point is displayed. If the cargo tank also contains gasoline and alcohol fuel blends...

  5. Pinning synchronization of delayed complex dynamical networks with nonlinear coupling

    NASA Astrophysics Data System (ADS)

    Cheng, Ranran; Peng, Mingshu; Yu, Weibin

    2014-11-01

    In this paper, we find that complex networks with the Watts-Strogatz or scale-free BA random topological architecture can be synchronized more easily by pin-controlling fewer nodes than regular systems. Theoretical analysis is included by means of Lyapunov functions and linear matrix inequalities (LMI) to make all nodes reach complete synchronization. Numerical examples are also provided to illustrate the importance of our theoretical analysis, which implies that there exists a gap between the theoretical prediction and numerical results about the minimum number of pinning controlled nodes.

  6. Dowel pin

    DOEpatents

    Wojcik, Thaddeus A.

    1978-01-01

    Two abutting members are locked together by reaming a hole entirely through one member and at least partly through the other, machining a circular groove in each through hole just below the surface of the member, press fitting a dowel pin having a thin wall extension on at least one end thereof into the hole in both members, a thin wall extension extending into each through hole, crimping or snapping the thin wall extension into the grooves to positively lock the dowel pin in place and, if necessary, tack welding the end of the thin-wall extension in place.

  7. A Biomechanical Comparison Of Pin Configurations Used For Percutaneous Pinning Of Distal Tibia Fractures In Children.

    PubMed

    Brantley, Justin; Majumdar, Aditi; Jobe, J Taylor; Kallur, Antony; Salas, Christina

    2016-01-01

    Percutaneous pin fixation is often used in conjunction with closed-reduction and cast immobilization to treat pediatric distal tibia fractures. The goal of this procedure is to maintain reduction and provide improved stabilization, in effort to facilitate a more anatomic union. We conducted a biomechanical study of the torsional and bending stability of three commonly used pin configurations in distal tibia fracture fixation. A transverse fracture was simulated at the metaphyseal/diaphyseal junction in 15 synthetic tibias. Each fracture was reduced and fixed with two Kirschner wires, arranged in one of three pin configurations: parallel, retrograde, medial to lateral pins entering at the medial malleolus distal to the fracture (group A); parallel, antegrade, medial to lateral pins entering at the medial diaphysis proximal to the fracture (group B); or a cross-pin configuration with one retrograde, medial to lateral pin entering the medial malleolus distal to the fracture and the second an antegrade, medial to lateral pin entering at the medial diaphysis proximal to the fracture (group C). Stability of each construct was assessed by resistance to torsion and bending. Resistance to external rotation stress was significantly higher in group A than group B (P = 0.044). Resistance to internal rotation stress was significantly higher in group C than group B (P = 0.003). There was no significant difference in torsional stiffness when comparing group A with group C. Under a medial-directed load, group B and C specimens were significantly stiffer than those in group A (28 N/mm and 24 N/mm vs. 14 N/mm for A; P = 0.001 and P = 0.009, respectively). None of the three pin configurations produced superior results with respect to all variables studied. Group A configuration provided the highest resistance to external rotation forces, which is the most clinically relevant variable under short-cast immobilization. Parallel, retrograde, medial to lateral pins entering at the medial

  8. The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice.

    PubMed

    Barberi, Theresa J; Dunkle, Alexis; He, You-Wen; Racioppi, Luigi; Means, Anthony R

    2012-01-01

    Pin1 has previously been described to regulate cells that participate in both innate and adaptive immunity. Thus far, however, no role for Pin1 has been described in modulating conventional dendritic cells, innate antigen presenting cells that potently activate naïve T cells, thereby bridging innate and adaptive immune responses. When challenged with LPS, Pin1-null mice failed to accumulate spleen conventional dendritic cells (cDC). Analysis of steady-state spleen DC populations revealed that Pin1-null mice had fewer CD8+ cDC. This defect was recapitulated by culturing Pin1-null bone marrow with the DC-instructive cytokine Flt3 Ligand. Additionally, injection of Flt3 Ligand for 9 days failed to induce robust expansion of CD8+ cDC in Pin1-null mice. Upon infection with Listeria monocytogenes, Pin1-null mice were defective in stimulating proliferation of adoptively transferred WT CD8+ T cells, suggesting that decreases in Pin1 null CD8+ cDC may affect T cell responses to infection in vivo. Finally, upon analyzing expression of proteins involved in DC development, elevated expression of PU.1 was detected in Pin1-null cells, which resulted from an increase in PU.1 protein half-life. We have identified a novel role for Pin1 as a modulator of CD8+ cDC development. Consistent with reduced numbers of CD8+ cDC in Pin1-null mice, we find that the absence of Pin1 impairs CD8+ T cell proliferation in response to infection with Listeria monocytogenes. These data suggest that, via regulation of CD8+ cDC production, Pin1 may serve as an important modulator of adaptive immunity.

  9. 49 CFR 172.336 - Identification numbers; special provisions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... fuels together with a gasoline and alcohol fuel blend containing more than ten percent ethanol, the... gasoline and alcohol fuel blend containing more than ten percent ethanol, the identification number “3475...). (3) On a cargo tank containing only fuel oil, if the cargo tank is marked “Fuel Oil” on each side and...

  10. 49 CFR 172.336 - Identification numbers; special provisions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... fuels together with a gasoline and alcohol fuel blend containing more than ten percent ethanol, the... gasoline and alcohol fuel blend containing more than ten percent ethanol, the identification number “3475...). (3) On a cargo tank containing only fuel oil, if the cargo tank is marked “Fuel Oil” on each side and...

  11. 49 CFR 172.336 - Identification numbers; special provisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... fuels together with a gasoline and alcohol fuel blend containing more than ten percent ethanol, the... gasoline and alcohol fuel blend containing more than ten percent ethanol, the identification number “3475...). (3) On a cargo tank containing only fuel oil, if the cargo tank is marked “Fuel Oil” on each side and...

  12. Heat transfer in thin, compact heat exchangers with circular, rectangular, or pin-fin flow passages

    NASA Technical Reports Server (NTRS)

    Olson, D. A.

    1992-01-01

    Heat transfer and pressure drop have been measured of three thin, compact heat exchangers in helium gas at 3.5 MPa and higher, with Reynolds numbers of 450 to 36,000. The flow geometries for the three heat exchanger specimens were: circular tube, rectangular channel, and staggered pin fin with tapered pins. The specimens were heated radiatively at heat fluxes up to 77 W/sq cm. Correlations were developed for the isothermal friction factor as a function of Reynolds number, and for the Nusselt number as a function of Reynolds number and the ratio of wall temperature to fluid temperature. The specimen with the pin fin internal geometry had significantly better heat transfer than the other specimens, but it also had higher pressure drop. For certain conditions of helium flow and heating, the temperature more than doubled from the inlet to the outlet of the specimens, producing large changes in gas velocity, density, viscosity, and thermal conductivity. These changes in properties did not affect the correlations for friction factor and Nusselt number in turbulent flow.

  13. Improved Quick-Release Pin Mechanism

    NASA Technical Reports Server (NTRS)

    Wright, Jay M.

    2007-01-01

    An improved quick-release pin mechanism supplants a prior such mechanism in which the pin bears a shear load to hold two objects together. The prior mechanism, of a ball-locking design, can fail when vibrations cause balls to fall out. The load-bearing pin is an outer tube with a handle at one end (hereafter denoted the near end). Within the outer tube is a spring-loaded inner tube that includes a handle at its near end and a pivoting tab at its far end. The pin is inserted through holes in the objects to be retained and the inner tube is pushed against an offset pivot inside the outer tube to make the tab rotate outward so that it protrudes past the outer diameter of the outer tube, and the spring load maintains this configuration so that the pin cannot be withdrawn through the holes. Pushing the handles together against the spring load moves the locking tab out far enough that the tab becomes free to rotate inward. Then releasing the inner-tube handle causes the tab to be pulled into a resting position inside the outer tube. The pin can then be pulled out through the holes.

  14. Management of Ingested Hijab-Pin.

    PubMed

    Hubara, Evyatar; Ling, Galina; Pinsk, Vered; Lior, Yotam; Daniel, Sharon; Zuckerman, Shalev; Yerushalmi, Baruch

    2017-06-01

    Accidental swallowing of hijab (or turban) pin was reported mainly among adolescent girls. Current guidelines indicate emergent intervention endoscopy in case a long sharp object is found in the gastrointestinal tract. The aims of the current study are to present the results of an observational approach and to assess the need for intervention. A retrospective cohort study was conducted including all 5-18-year-old patients who presented with hijab-pin ingestion between 2003 and 2014. The need for intervention was assessed using both univariable and multivariable statistical analyses. Two hundred three cases of hijab-pin ingestion were documented. In the majority of cases, the pin was observed in the stomach (137/203, 67.4%) upon arrival. Most pins that were located at the upper gastrointestinal tract (proximal to the ligament of Treitz) ejected spontaneously (120/169, 71%, Pv = 0.005). The absence of pin progression in an X-ray performed 12 h following presentation was significantly more frequent in the intervention group (46/51, 90%, Pv = 0.001). In most cases, the outcome is spontaneous ejection from the digestive tract. However, if needle location remains unchanged on two consecutive X-rays, an endoscopic intervention is recommended.

  15. Self-locking double retention redundant pull pin release

    NASA Technical Reports Server (NTRS)

    Killgrove, Thomas O. (Inventor)

    1987-01-01

    A double-retention redundant pull pin release system is disclosed. The system responds to a single pull during an intentional release operation. A spiral-threaded main pin is seated in a mating bore in a housing, which main pin has a flange fastened thereon at the part of the main pin which is exterior to the housing. Accidental release tends to rotate the main pin. A secondary pin passes through a slightly oversized opening in the flange and is seated in a second bore in the housing. The pins counteract against one another to prevent accidental release. A frictional lock is shared between the main and secondary pins to enhance further locking of the system. The secondary pin, in response to a first pull, is fully retracted from its bore and flange hole. Thereafter the pull causes the main pin to rotate free of the housing to release, for example, a parachute mechanism.

  16. 24 CFR 206.40 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 206.40 Section 206.40 Housing and Urban Development... Eligibility; Endorsement Eligible Mortgagors § 206.40 Disclosure and verification of Social Security and... verification of Social Security and Employer Identification Numbers, as provided by part 200, subpart U, of...

  17. 24 CFR 241.626 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 241.626 Section 241.626 Housing and Urban... verification of Social Security and Employer Identification Numbers. To be eligible for loan insurance under this subpart, the borrower must meet the requirements for the disclosure and verification of Social...

  18. 24 CFR 206.40 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 206.40 Section 206.40 Housing and Urban Development... Eligibility; Endorsement Eligible Mortgagors § 206.40 Disclosure and verification of Social Security and... verification of Social Security and Employer Identification Numbers, as provided by part 200, subpart U, of...

  19. 24 CFR 241.626 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 241.626 Section 241.626 Housing and Urban... verification of Social Security and Employer Identification Numbers. To be eligible for loan insurance under this subpart, the borrower must meet the requirements for the disclosure and verification of Social...

  20. 24 CFR 241.626 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 241.626 Section 241.626 Housing and Urban... verification of Social Security and Employer Identification Numbers. To be eligible for loan insurance under this subpart, the borrower must meet the requirements for the disclosure and verification of Social...

  1. 24 CFR 206.40 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 206.40 Section 206.40 Housing and Urban Development... Eligibility; Endorsement Eligible Mortgagors § 206.40 Disclosure and verification of Social Security and... verification of Social Security and Employer Identification Numbers, as provided by part 200, subpart U, of...

  2. 24 CFR 206.40 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 206.40 Section 206.40 Housing and Urban Development... Eligibility; Endorsement Eligible Mortgagors § 206.40 Disclosure and verification of Social Security and... verification of Social Security and Employer Identification Numbers, as provided by part 200, subpart U, of...

  3. 24 CFR 241.626 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 241.626 Section 241.626 Housing and Urban... verification of Social Security and Employer Identification Numbers. To be eligible for loan insurance under this subpart, the borrower must meet the requirements for the disclosure and verification of Social...

  4. 24 CFR 206.40 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 206.40 Section 206.40 Housing and Urban Development... Eligibility; Endorsement Eligible Mortgagors § 206.40 Disclosure and verification of Social Security and... verification of Social Security and Employer Identification Numbers, as provided by part 200, subpart U, of...

  5. 24 CFR 241.626 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 241.626 Section 241.626 Housing and Urban... verification of Social Security and Employer Identification Numbers. To be eligible for loan insurance under this subpart, the borrower must meet the requirements for the disclosure and verification of Social...

  6. Antimicrobial efficacy of external fixator pins coated with a lipid stabilized hydroxyapatite/chlorhexidine complex to prevent pin tract infection in a goat model.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dejong, E. Schuyler; Deberardino, T. M.; Brooks, D. E.

    Background: Pin tract infection is a common complication of external fixation. An antiinfective external fixator pin might help to reduce the incidence of pin tract infection and improve pin fixation. Methods: Stainless steel and titanium external fixator pins, with and without a lipid stabilized hydroxyapatite/chlorhexidine coating, were evaluated in a goat model. Two pins contaminated with an identifiable Staphylococcus aureus strain were inserted into each tibia of 12 goats. The pin sites were examined daily. On day 14, the animals were killed, and the pin tips cultured. Insertion and extraction torques were measured. Results: Infection developed in 100% of uncoatedmore » pins, whereas coated pins demonstrated 4.2% infected, 12.5% colonized, and the remainder, 83.3%, had no growth (p < 0.01). Pin coating decreased the percent loss of fixation torque over uncoated pins (p = 0.04). Conclusion: These results demonstrate that the lipid stabilized hydroxyapatite/chlorhexidine coating was successful in decreasing infection and improving fixation of external fixator pins.« less

  7. Heat Exchanger With Internal Pin Elements

    DOEpatents

    Gerstmann, Joseph; Hannon, Charles L.

    2004-01-13

    A heat exchanger/heater comprising a tubular member having a fluid inlet end, a fluid outlet end and plurality of pins secured to the interior wall of the tube. Various embodiments additionally comprise a blocking member disposed concentrically inside the pins, such as a core plug or a baffle array. Also disclosed is a vapor generator employing an internally pinned tube, and a fluid-heater/heat-exchanger utilizing an outer jacket tube and fluid-side baffle elements, as well as methods for heating a fluid using an internally pinned tube.

  8. Pin fin compliant heat sink with enhanced flexibility

    DOEpatents

    Schultz, Mark D.

    2018-04-10

    Heat sinks and methods of using the same include a top and bottom plate, at least one of which has a plurality of pin contacts flexibly connected to one another, where the plurality of pin contacts have vertical and lateral flexibility with respect to one another; and pin slice layers, each having multiple pin slices, arranged vertically between the top and bottom plates such that the plurality of pin slices form substantially vertical pins connecting the top and bottom plates.

  9. Nanoscale pinning effect evaluated from deformed nanobubbles.

    PubMed

    Teshima, Hideaki; Nishiyama, Takashi; Takahashi, Koji

    2017-01-07

    Classical thermodynamics theory predicts that nanosized bubbles should disappear in a few hundred microseconds. The surprisingly long lifetime and stability of nanobubbles are therefore interesting research subjects. It has been proposed that the stability of nanobubbles arises through pinning of the three-phase contact line, which results from intrinsic nanoscale geometrical and chemical heterogeneities of the substrate. However, a definitive explanation of nanobubble stability is still lacking. In this work, we examined the stability mechanism by introducing a "pinning force." We investigated nanobubbles at a highly ordered pyrolytic graphite/pure water interface by peak force quantitative nano-mechanical mapping and estimated the pinning force and determined its maximum value. We then observed the shape of shrinking nanobubbles. Because the diameter of the shrinking nanobubbles was pinned, the height decreased and the contact angle increased. This phenomenon implies that the stability results from the pinning force, which flattens the bubble through the pinned three-phase contact line and prevents the Laplace pressure from increasing. The pinning force can also explain the metastability of coalesced nanobubbles, which have two semispherical parts that are joined to form a dumbbell-like shape. The pinning force of the semispherical parts was stronger than that of the joint region. This result demonstrates that the contact line of the semispherical parts is pinned strongly to keep the dumbbell-like shape. Furthermore, we proposed a nanobubble generation mechanism for the solvent-exchange method and explained why the pinning force of large nanobubbles was not initially at its maximum value, as it was for small nanobubbles.

  10. Nanoscale pinning effect evaluated from deformed nanobubbles

    NASA Astrophysics Data System (ADS)

    Teshima, Hideaki; Nishiyama, Takashi; Takahashi, Koji

    2017-01-01

    Classical thermodynamics theory predicts that nanosized bubbles should disappear in a few hundred microseconds. The surprisingly long lifetime and stability of nanobubbles are therefore interesting research subjects. It has been proposed that the stability of nanobubbles arises through pinning of the three-phase contact line, which results from intrinsic nanoscale geometrical and chemical heterogeneities of the substrate. However, a definitive explanation of nanobubble stability is still lacking. In this work, we examined the stability mechanism by introducing a "pinning force." We investigated nanobubbles at a highly ordered pyrolytic graphite/pure water interface by peak force quantitative nano-mechanical mapping and estimated the pinning force and determined its maximum value. We then observed the shape of shrinking nanobubbles. Because the diameter of the shrinking nanobubbles was pinned, the height decreased and the contact angle increased. This phenomenon implies that the stability results from the pinning force, which flattens the bubble through the pinned three-phase contact line and prevents the Laplace pressure from increasing. The pinning force can also explain the metastability of coalesced nanobubbles, which have two semispherical parts that are joined to form a dumbbell-like shape. The pinning force of the semispherical parts was stronger than that of the joint region. This result demonstrates that the contact line of the semispherical parts is pinned strongly to keep the dumbbell-like shape. Furthermore, we proposed a nanobubble generation mechanism for the solvent-exchange method and explained why the pinning force of large nanobubbles was not initially at its maximum value, as it was for small nanobubbles.

  11. 7 CFR 201.13 - Lot number or other identification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Lot number or other identification. 201.13 Section 201.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling...

  12. 7 CFR 201.13 - Lot number or other identification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Lot number or other identification. 201.13 Section 201.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling...

  13. 7 CFR 201.13 - Lot number or other identification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Lot number or other identification. 201.13 Section 201.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling...

  14. 7 CFR 201.13 - Lot number or other identification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Lot number or other identification. 201.13 Section 201.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling...

  15. 7 CFR 201.13 - Lot number or other identification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Lot number or other identification. 201.13 Section 201.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling...

  16. 26 CFR 31.6011(b)-1 - Employers' identification numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... any district director or director of a service center or any district office of the Social Security... applicable to Form SS-4, or with the nearest district office of the Social Security Administration. The... forms, regulations, and instructions. For provisions relating to the inclusion of identification numbers...

  17. 27 CFR 70.113 - Penalty for failure to supply taxpayer identification number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... supply taxpayer identification number. 70.113 Section 70.113 Alcohol, Tobacco Products and Firearms..., Additional Amounts, and Assessable Penalties § 70.113 Penalty for failure to supply taxpayer identification... notice and demand therefor. (b) Reasonable cause. If any person who is required by the regulations under...

  18. Integral Fast Reactor fuel pin processor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Levinskas, D.

    1993-01-01

    This report discusses the pin processor which receives metal alloy pins cast from recycled Integral Fast Reactor (IFR) fuel and prepares them for assembly into new IFR fuel elements. Either full length as-cast or precut pins are fed to the machine from a magazine, cut if necessary, and measured for length, weight, diameter and deviation from straightness. Accepted pins are loaded into cladding jackets located in a magazine, while rejects and cutting scraps are separated into trays. The magazines, trays, and the individual modules that perform the different machine functions are assembled and removed using remote manipulators and master-slaves.

  19. Integral Fast Reactor fuel pin processor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Levinskas, D.

    1993-03-01

    This report discusses the pin processor which receives metal alloy pins cast from recycled Integral Fast Reactor (IFR) fuel and prepares them for assembly into new IFR fuel elements. Either full length as-cast or precut pins are fed to the machine from a magazine, cut if necessary, and measured for length, weight, diameter and deviation from straightness. Accepted pins are loaded into cladding jackets located in a magazine, while rejects and cutting scraps are separated into trays. The magazines, trays, and the individual modules that perform the different machine functions are assembled and removed using remote manipulators and master-slaves.

  20. Curvature-induced domain wall pinning

    NASA Astrophysics Data System (ADS)

    Yershov, Kostiantyn V.; Kravchuk, Volodymyr P.; Sheka, Denis D.; Gaididei, Yuri

    2015-09-01

    It is shown that a local bend of a nanowire is a source of pinning potential for a transversal head-to-head (tail-to-tail) domain wall. Eigenfrequency of the domain wall free oscillations at the pinning potential and the effective friction are determined as functions of the curvature and domain wall width. The pinning potential originates from the effective curvature-induced Dzyaloshinsky-like term in the exchange energy. The theoretical results are verified by means of micromagnetic simulations for the case of parabolic shape of the wire bend.

  1. Contact stresses in pin-loaded orthotropic plates

    NASA Technical Reports Server (NTRS)

    Hyer, M. W.; Klang, E. C.

    1984-01-01

    The effects of pin elasticity, friction, and clearance on the stresses near the hole in a pin-loaded orthotropic plate are described. The problem is modeled as a contact elasticity problem using complex variable theory, the pin and the plate being two elastic bodies interacting through contact. This modeling is in contrast to previous works which assumed that the pin is rigid or that it exerts a known cosinusoidal radial traction on the hole boundary. Neither of these approaches explicitly involves a pin. A collocation procedure and iteration were used to obtain numerical results for a variety of plate and pin elastic properties and various levels of friction and clearance. Collocation was used to enforce the boundary and iteration was used to find the contact and no-slip regions on the boundary. Details of the numerical scheme are discussed.

  2. Transverse pinning versus intramedullary pinning in fifth metacarpal's neck fractures: A randomized controlled study with patient-reported outcome.

    PubMed

    Galal, Sherif; Safwat, Wael

    2017-01-01

    The 5th metacarpal fractures accounts for 38% of all hand fractures given that the neck is the weakest point in metacarpals, so neck fracture is the most common metacarpal fracture. Surgical fixation is also advocated for such fractures to prevent mal-rotation of the little finger which will lead to fingers overlap in a clenched fist. Various methods are available for fixation of such fractures, like intramedullary & transverse pinning. There are very few reports in the literature comparing both techniques. Authors wanted to compare outcomes and complications of transverse pinning versus intramedullary pinning in fifth metacarpal's neck fractures. A single-center, parallel group, prospective, randomized study was conducted at an academic Level 1 Trauma Center from October 2014 to December 2016. A total of 80 patients with 5th metacarpal's neck fractures were randomized to pinning using either transverse pinning (group A) or intramedullary pinning (group B). Patients were assessed clinically on range of motion, patient-reported outcome using the Quick-DASH (Disabilities of the Arm, Shoulder, and Hand) questionnaire & radiographically. Two blinded observers assessed outcomes. At final follow up for each patient (12 months) the statistically significant differences were observed in operative time, the transverse pinning group showed shorter operative time, as well as complication rate as complications were observed only in intramedullary pinning group. No differences were found in range of motion or the Quick -DASH score. Both techniques are equally safe and effective treatment option for 5th metacarpal's neck fractures. The only difference was shorter operative time & less incidence of complications in transverse pinning group. Level II, Therapeutic study.

  3. Development of 3D pseudo pin-by-pin calculation methodology in ANC

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, B.; Mayhue, L.; Huria, H.

    2012-07-01

    Advanced cores and fuel assembly designs have been developed to improve operational flexibility, economic performance and further enhance safety features of nuclear power plants. The simulation of these new designs, along with strong heterogeneous fuel loading, have brought new challenges to the reactor physics methodologies currently employed in the industrial codes for core analyses. Control rod insertion during normal operation is one operational feature in the AP1000{sup R} plant of Westinghouse next generation Pressurized Water Reactor (PWR) design. This design improves its operational flexibility and efficiency but significantly challenges the conventional reactor physics methods, especially in pin power calculations. Themore » mixture loading of fuel assemblies with significant neutron spectrums causes a strong interaction between different fuel assembly types that is not fully captured with the current core design codes. To overcome the weaknesses of the conventional methods, Westinghouse has developed a state-of-the-art 3D Pin-by-Pin Calculation Methodology (P3C) and successfully implemented in the Westinghouse core design code ANC. The new methodology has been qualified and licensed for pin power prediction. The 3D P3C methodology along with its application and validation will be discussed in the paper. (authors)« less

  4. 27 CFR 25.169 - Application for employer identification number.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Application for employer identification number. 25.169 Section 25.169 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax...

  5. 27 CFR 25.169 - Application for employer identification number.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Application for employer identification number. 25.169 Section 25.169 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax...

  6. 27 CFR 25.169 - Application for employer identification number.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Application for employer identification number. 25.169 Section 25.169 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Preparation and Remittance of Tax...

  7. 27 CFR 25.169 - Application for employer identification number.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Application for employer identification number. 25.169 Section 25.169 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Preparation and Remittance of Tax...

  8. 27 CFR 25.169 - Application for employer identification number.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Application for employer identification number. 25.169 Section 25.169 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax...

  9. Improving tribological and anti-bacterial properties of titanium external fixation pins through surface ceramic conversion.

    PubMed

    Dong, Huan; Mukinay, Tatiana; Li, Maojun; Hood, Richard; Soo, Sein Leung; Cockshott, Simon; Sammons, Rachel; Li, Xiaoying

    2017-01-01

    In this study, an advanced ceramic conversion surface engineering technology has been applied for the first time to self-drilling Ti6Al4V external fixation pins to improve their performance in terms of biomechanical, bio-tribological and antibacterial properties. Systematic characterisation of the ceramic conversion treated Ti pins was carried out using Scanning electron microscope, X-ray diffraction, Glow-discharge optical emission spectroscopy, nano- and micro-indentation and scratching; the biomechanical and bio-tribological properties of the surface engineered Ti pins were evaluated by insertion into high density bone simulation material; and the antibacterial behaviour was assessed with Staphylococcus aureus NCTC 6571. The experimental results have demonstrated that the surfaces of Ti6Al4V external fixation pins were successfully converted into a TiO 2 rutile layer (~2 μm in thickness) supported by an oxygen hardened case (~15 μm in thickness) with very good bonding due to the in-situ conversion nature. The maximum insertion force and temperature were reduced from 192N and 31.2 °C when using the untreated pins to 182N and 26.1 °C when the ceramic conversion treated pins were tested. This is mainly due to the significantly increased hardness (more than three times) and the effectively enhanced wear resistance of the cutting edge of the self-drilling Ti pins following the ceramic conversion treatment. The antibacterial tests also revealed that there was a significantly reduced number of bacteria isolated from the ceramic conversion treated pins compared to the untreated pins of around 50 % after 20 h incubation, P < 0.01 (0.0024). The results reported are encouraging and could pave the way towards high-performance anti-bacterial titanium external fixation pins with reduced pin-track infection and pin loosing.

  10. Jersey number detection in sports video for athlete identification

    NASA Astrophysics Data System (ADS)

    Ye, Qixiang; Huang, Qingming; Jiang, Shuqiang; Liu, Yang; Gao, Wen

    2005-07-01

    Athlete identification is important for sport video content analysis since users often care about the video clips with their preferred athletes. In this paper, we propose a method for athlete identification by combing the segmentation, tracking and recognition procedures into a coarse-to-fine scheme for jersey number (digital characters on sport shirt) detection. Firstly, image segmentation is employed to separate the jersey number regions with its background. And size/pipe-like attributes of digital characters are used to filter out candidates. Then, a K-NN (K nearest neighbor) classifier is employed to classify a candidate into a digit in "0-9" or negative. In the recognition procedure, we use the Zernike moment features, which are invariant to rotation and scale for digital shape recognition. Synthetic training samples with different fonts are used to represent the pattern of digital characters with non-rigid deformation. Once a character candidate is detected, a SSD (smallest square distance)-based tracking procedure is started. The recognition procedure is performed every several frames in the tracking process. After tracking tens of frames, the overall recognition results are combined to determine if a candidate is a true jersey number or not by a voting procedure. Experiments on several types of sports video shows encouraging result.

  11. Automated fuel pin loading system

    DOEpatents

    Christiansen, David W.; Brown, William F.; Steffen, Jim M.

    1985-01-01

    An automated loading system for nuclear reactor fuel elements utilizes a gravity feed conveyor which permits individual fuel pins to roll along a constrained path perpendicular to their respective lengths. The individual lengths of fuel cladding are directed onto movable transports, where they are aligned coaxially with the axes of associated handling equipment at appropriate production stations. Each fuel pin can be reciprocated axially and/or rotated about its axis as required during handling steps. The fuel pins are inserted as a batch prior to welding of end caps by one of two disclosed welding systems.

  12. Automated fuel pin loading system

    DOEpatents

    Christiansen, D.W.; Brown, W.F.; Steffen, J.M.

    An automated loading system for nuclear reactor fuel elements utilizes a gravity feed conveyor which permits individual fuel pins to roll along a constrained path perpendicular to their respective lengths. The individual lengths of fuel cladding are directed onto movable transports, where they are aligned coaxially with the axes of associated handling equipment at appropriate production stations. Each fuel pin can be be reciprocated axially and/or rotated about its axis as required during handling steps. The fuel pins are inerted as a batch prior to welding of end caps by one of two disclosed welding systems.

  13. Overexpression of PvPin1, a Bamboo Homolog of PIN1-Type Parvulin 1, Delays Flowering Time in Transgenic Arabidopsis and Rice

    PubMed Central

    Zheng, Zhigang; Yang, Xiaoming; Fu, Yaping; Zhu, Longfei; Wei, Hantian; Lin, Xinchun

    2017-01-01

    Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition by facilitating the cis/trans isomerization of the phosphorylated Ser/Thr residues preceding proline motifs in suppressor of overexpression of CO 1 (SOC1) and agamous-like 24 (AGL24). Whether bamboo has a Pin1 homolog and whether it works in bamboo flowering are still unknown. In this study, we cloned PvPin1, a homolog of Pin1At, from Phyllostachys violascens (Bambusoideae). Bioinformatics analysis showed that PvPin1 is closely related to Pin1-like proteins in monocots. PvPin1 was widely expressed in all tested bamboo tissues, with the highest expression in young leaf and lowest in floral bud. Moreover, PvPin1 expression was high in leaves before bamboo flowering then declined during flower development. Overexpression of PvPin1 significantly delayed flowering time by downregulating SOC1 and AGL24 expression in Arabidopsis under greenhouse conditions and conferred a significantly late flowering phenotype by upregulating OsMADS56 in rice under field conditions. PvPin1 showed subcellular localization in both the nucleus and cytolemma. The 1500-bp sequence of the PvPin1 promoter was cloned, and cis-acting element prediction showed that ABRE and TGACG-motif elements, which responded to abscisic acid (ABA) and methyl jasmonate (MeJA), respectively, were characteristic of P. violascens in comparison with Arabidopsis. On promoter activity analysis, exogenous ABA and MeJA could significantly inhibit PvPin1 expression. These findings suggested that PvPin1 may be a repressor in flowering, and its delay of flowering time could be regulated by ABA and MeJA in bamboo. PMID:28951734

  14. Overexpression of PvPin1, a Bamboo Homolog of PIN1-Type Parvulin 1, Delays Flowering Time in Transgenic Arabidopsis and Rice.

    PubMed

    Zheng, Zhigang; Yang, Xiaoming; Fu, Yaping; Zhu, Longfei; Wei, Hantian; Lin, Xinchun

    2017-01-01

    Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition by facilitating the cis/trans isomerization of the phosphorylated Ser/Thr residues preceding proline motifs in suppressor of overexpression of CO 1 (SOC1) and agamous-like 24 (AGL24). Whether bamboo has a Pin1 homolog and whether it works in bamboo flowering are still unknown. In this study, we cloned PvPin1 , a homolog of Pin1At , from Phyllostachys violascens (Bambusoideae). Bioinformatics analysis showed that PvPin1 is closely related to Pin1-like proteins in monocots. PvPin1 was widely expressed in all tested bamboo tissues, with the highest expression in young leaf and lowest in floral bud. Moreover, PvPin1 expression was high in leaves before bamboo flowering then declined during flower development. Overexpression of PvPin1 significantly delayed flowering time by downregulating SOC1 and AGL24 expression in Arabidopsis under greenhouse conditions and conferred a significantly late flowering phenotype by upregulating OsMADS56 in rice under field conditions. PvPin1 showed subcellular localization in both the nucleus and cytolemma. The 1500-bp sequence of the PvPin1 promoter was cloned, and cis -acting element prediction showed that ABRE and TGACG-motif elements, which responded to abscisic acid (ABA) and methyl jasmonate (MeJA), respectively, were characteristic of P. violascens in comparison with Arabidopsis . On promoter activity analysis, exogenous ABA and MeJA could significantly inhibit PvPin1 expression. These findings suggested that PvPin1 may be a repressor in flowering, and its delay of flowering time could be regulated by ABA and MeJA in bamboo.

  15. Mechanical evaluation of external skeletal fixator-intramedullary pin tie-in configurations applied to cadaveral humeri from red-tailed hawks (Buteo jamaicensis).

    PubMed

    Van Wettere, Arnaud J; Redig, Patrick T; Wallace, Larry J; Bourgeault, Craig A; Bechtold, Joan E

    2009-12-01

    Use of external skeletal fixator-intramedullary pin (ESF-IM) tie-in fixators is an adjustable and effective method of fracture fixation in birds. The objective of this study was to determine the contribution of each of the following parameters to the compressive and torsional rigidity of an ESF-IM pin tie-in applied to avian bones with an osteotomy gap: (1) varying the fixation pin position in the proximal bone segment and (2) increasing the number of fixation pins in one or both bone segments. ESF-IM pin tie-in constructs were applied to humeri harvested from red-tailed hawks (Buteo jamaicensis) (n=24) that had been euthanatized for clinical reasons. Constructs with a variation in the placement of the proximal fixation pin and with 2, 3, or 4 fixation pins applied to avian bone with an osteotomy gap were loaded to a defined displacement in torque and axial compression. Response variables were determined from resulting load-displacement curves (construct stiffness, load at 1-mm displacement). Increasing the number of fixation pins from 1 to 2 per bone segment significantly increased the stiffness in torque (110%) and compression (60%), and the safe load in torque (107%) and compression (50%). Adding a fixation pin to the distal bone segment to form a 3-pin fixator significantly increased the stiffness (27%) and safe load (20%) in torque but not in axial compression. In the configuration with 2 fixation pins, placing the proximal pin distally in the proximal bone segment significantly increased the stiffness in torque (28%), and the safe load in torque (23%) and in axial compression (32%). Results quantified the relative importance of specific parameters affecting the rigidity of ESF-IM pin tie-in constructs as applied to unstable bone fracture models in birds.

  16. Differential pressure pin discharge apparatus

    DOEpatents

    Oakley, David J.

    1987-02-03

    Disclosed is a discharge assembly for allowing elongate pins to be discharged from an area of relatively low pressure to an area of relatively greater pressure. The discharge assembly includes a duck valve having a lip piece made of flexible material. The flexible lip piece responds to a fluctuating pressure created downstream by an aspirator. The aspirator reduces the downstream pressure sensed by the duck valve when the discharge assembly is in the open position. This allows elongate pins to be moved through the duck valve with no backflow because the aspirator pressure is less than the pressure in the low pressure area from which the pins originate. Closure of the assembly causes the aspirator static pressure to force the flexible duck valve lip piece into a tightly sealed position also preventing backflow. The discharge assembly can be easily controlled using a single control valve which blocks the flow of aspirator gas and closes the pin passageway extending through the assembly.

  17. Differential pressure pin discharge apparatus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oakley, D.J.

    Disclosed is a discharge assembly for allowing elongate pins to be discharged from an area of relatively low pressure to an area of relatively greater pressure. The discharge assembly includes a duck valve having a lip piece made of flexible material. The flexible lip piece responds to a fluctuating pressure created downstream by an aspirator. The aspirator reduces the downstream pressure sensed by the duck valve when the discharge assembly is in the open position. This allows elongate pins to be moved through the duck valve with no backflow because the aspirator pressure is less than the pressure in themore » low pressure area from which the pins originate. Closure of the assembly causes the aspirator static pressure to force the flexible duck valve lip piece into a tightly sealed position also preventing backflow. The discharge assembly can be easily controlled using a single control valve which blocks the flow of aspirator gas and closes the pins passageway extending through the assembly.« less

  18. Differential pressure pin discharge apparatus

    DOEpatents

    Oakley, D.J.

    1984-05-30

    Disclosed is a discharge assembly for allowing elongate pins to be discharged from an area of relatively low pressure to an area of relatively greater pressure. The discharge assembly includes a duck valve having a lip piece made of flexible material. The flexible lip piece responds to a fluctuating pressure created downstream by an aspirator. The aspirator reduces the downstream pressure sensed by the duck valve when the discharge assembly is in the open position. This allows elongate pins to be moved through the duck valve with no backflow because the aspirator pressure is less than the pressure in the low pressure area from which the pins originate. Closure of the assembly causes the aspirator static pressure to force the flexible duck valve lip piece into a tightly sealed position also preventing backflow. The discharge assembly can be easily controlled using a single control valve which blocks the flow of aspirator gas and closes the pins passageway extending through the assembly.

  19. Differential pressure pin discharge apparatus

    DOEpatents

    Oakley, David J.

    1987-01-01

    Disclosed is a discharge assembly for allowing elongate pins to be discharged from an area of relatively low pressure to an area of relatively greater pressure. The discharge assembly includes a duck valve having a lip piece made of flexible material. The flexible lip piece responds to a fluctuating pressure created downstream by an aspirator. The aspirator reduces the downstream pressure sensed by the duck valve when the discharge assembly is in the open position. This allows elongate pins to be moved through the duck valve with no backflow because the aspirator pressure is less than the pressure in the low pressure area from which the pins originate. Closure of the assembly causes the aspirator static pressure to force the flexible duck valve lip piece into a tightly sealed position also preventing backflow. The discharge assembly can be easily controlled using a single control valve which blocks the flow of aspirator gas and closes the pin passageway extending through the assembly.

  20. Enhanced pinning in superconducting thin films with graded pinning landscapes

    NASA Astrophysics Data System (ADS)

    Motta, M.; Colauto, F.; Ortiz, W. A.; Fritzsche, J.; Cuppens, J.; Gillijns, W.; Moshchalkov, V. V.; Johansen, T. H.; Sanchez, A.; Silhanek, A. V.

    2013-05-01

    A graded distribution of antidots in superconducting a-Mo79Ge21 thin films has been investigated by magnetization and magneto-optical imaging measurements. The pinning landscape has maximum density at the sample border, decreasing linearly towards the center. Its overall performance is noticeably superior than that for a sample with uniformly distributed antidots: For high temperatures and low fields, the critical current is enhanced, whereas the region of thermomagnetic instabilities in the field-temperature diagram is significantly suppressed. These findings confirm the relevance of graded landscapes on the enhancement of pinning efficiency, as recently predicted by Misko and Nori [Phys. Rev. B 85, 184506 (2012)].

  1. Procedure of recovery of pin-by-pin fields of energy release in the core of VVER-type reactor for the BIPR-8 code

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gordienko, P. V., E-mail: gorpavel@vver.kiae.ru; Kotsarev, A. V.; Lizorkin, M. P.

    2014-12-15

    The procedure of recovery of pin-by-pin energy-release fields for the BIPR-8 code and the algorithm of the BIPR-8 code which is used in nodal computation of the reactor core and on which the recovery of pin-by-pin fields of energy release is based are briefly described. The description and results of the verification using the module of recovery of pin-by-pin energy-release fields and the TVS-M program are given.

  2. 78 FR 15337 - IRS Truncated Taxpayer Identification Numbers; Hearing Cancellation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-11

    ... Service (IRS), Treasury. ACTION: Cancellation of a notice of public hearing on proposed rulemaking. SUMMARY: This document cancels a public hearing on proposed regulations under the Internal Revenue Code... IRS truncated taxpayer identification number, a TTIN. DATES: The public hearing, originally scheduled...

  3. Vortex Flux Pinning in Type-Ii Superconductors

    NASA Astrophysics Data System (ADS)

    Hasan, Mohammad-Khair A. M.

    1995-01-01

    Rotational magnetization vector measurements on polycrystalline samples of rm YBa_2Cu _3O_7 (YBCO) and (Ba, K)BiO _3 at various fixed fields (H) and temperatures (T) reveal that the vortex flux density (B) in a rotational state consists of a component B_{rm R}, which rotates rigidly with sample rotation, and a B_{rm F} component, which stays at a fixed frictional angle (theta _{rm F}) relative to H. Also, B_{rm R} decreases and ultimately vanishes with increasing H, while B _{rm F} grows monotonically, implying that the vortex pinning strength have a broad distribution. This has been confirmed by the measurements on YBCO of the remanent flux density B^ {rm rm} which can be decomposed analogously into B_{R} ^{} and B_ {F}^{} at angle theta_{F}^{} relative to H. The quantity Hsin theta_{rm F},, which at equilibrium equals tau_{rm p}/mu (the average pinning torque per vortex of moment mu) decreases with increasing high H. This result and the distribution in the strength of the pinning are shown to be consistent with the collective pinning process of vortex bundling. At fixed H, tau_{rm p} decreases rapidly with increasing T, varying approximately as T^{-0.8} for both samples. For polycrystalline YBCO at 4.2 K, B_ {rm R} and B_{ rm F} are found to relax differently with time. The negative creep sign of B_ {rm R} indicates that the number of rotational vortices decreases with time, whereas B _{rm F} shows a positive creep with a negative change in theta_ {rm F}, which indicates that more frictional vortices enter the sample with a tendency of alignment in the direction of H. For grain-oriented YBCO at 4.2 K, the vortex creep measurements of B along the c-axis at different fields showed that: whenever the hysteretic changes of H are reversed in sign, the vortex flux creep (dB/dlogt) decreases very rapidly to zero, where it lingers before changing sign. At the same turning values of H, (dB/dH) also goes to zero. These properties are attributable to the reversals of the

  4. Cross-species functional diversity within the PIN auxin efflux protein family

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    O'Connor, Devin Lee; Elton, Samuel; Ticchiarelli, Fabrizio

    In Arabidopsis, development during flowering is coordinated by transport of the hormone auxin mediated by polar-localized PIN-FORMED1 (AtPIN1). However Arabidopsis has lost a PIN clade sister to AtPIN1, Sister-of-PIN1 (SoPIN1), which is conserved in flowering plants. Here, we previously proposed that the AtPIN1 organ initiation and vein patterning functions are split between the SoPIN1 and PIN1 clades in grasses. Here we show that in the grass Brachypodium sopin1 mutants have organ initiation defects similar to Arabidopsis atpin1, while loss of PIN1 function in Brachypodium has little effect on organ initiation but alters stem growth. Heterologous expression of Brachypodium SoPIN1 andmore » PIN1b in Arabidopsis provides further evidence of functional specificity. SoPIN1 but not PIN1b can mediate flower formation in null atpin1 mutants, although both can complement a missense allele. The behavior of SoPIN1 and PIN1b in Arabidopsis illustrates how membrane and tissue-level accumulation, transport activity, and interaction contribute to PIN functional specificity.« less

  5. Cross-species functional diversity within the PIN auxin efflux protein family

    DOE PAGES

    O'Connor, Devin Lee; Elton, Samuel; Ticchiarelli, Fabrizio; ...

    2017-10-24

    In Arabidopsis, development during flowering is coordinated by transport of the hormone auxin mediated by polar-localized PIN-FORMED1 (AtPIN1). However Arabidopsis has lost a PIN clade sister to AtPIN1, Sister-of-PIN1 (SoPIN1), which is conserved in flowering plants. Here, we previously proposed that the AtPIN1 organ initiation and vein patterning functions are split between the SoPIN1 and PIN1 clades in grasses. Here we show that in the grass Brachypodium sopin1 mutants have organ initiation defects similar to Arabidopsis atpin1, while loss of PIN1 function in Brachypodium has little effect on organ initiation but alters stem growth. Heterologous expression of Brachypodium SoPIN1 andmore » PIN1b in Arabidopsis provides further evidence of functional specificity. SoPIN1 but not PIN1b can mediate flower formation in null atpin1 mutants, although both can complement a missense allele. The behavior of SoPIN1 and PIN1b in Arabidopsis illustrates how membrane and tissue-level accumulation, transport activity, and interaction contribute to PIN functional specificity.« less

  6. Investigation on Bond-Slip Behavior of Z-Pin Interfaces in X-Cor® Sandwich Structures Using Z-Pin Pull-Out Test

    NASA Astrophysics Data System (ADS)

    Shan, Hangying; Xiao, Jun; Chu, Qiyi

    2018-05-01

    The Z-Pin interfacial bond properties play an important role in the structural performance of X-Cor® sandwich structures. This paper presents an experimental investigation on bond-slip behavior of Z-Pin interfaces using Z-Pin pull-out test. Based on the experimental data the whole Z-Pin pull-out process consists of three stages: initial bonding, debonding and frictional sliding. Comparative experimental study on the influence of design parameters on bond-slip behavior of Z-Pin interfaces has also been performed. Numerical analyses were conducted with the ABAQUS finite element (FE) program to simulate the Z-Pins bond-slip response of the pull-out test. The Z-Pins interfacial bond-slip behavior was implemented using nonlinear spring elements characterized with the constitutive relation from experimental results. Numerical results were validated by comparison with experimental data, and reasonably good agreement was achieved between experimental and analytical pull-out force-slip curves.

  7. Effects of Pin Detached Space on Heat Transfer in a Rib Roughened Channel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siw, Sin Chien; Chyu, Minking K.; Alvin, Mary Anne

    2012-11-08

    An experimental study is performed to investigate the heat transfer characteristics and frictional losses in a rib roughened channel combined with detached pin-fins. The overall channel geometry (W=76.2 mm, E=25.4 mm) simulates an internal cooling passage of wide aspect ratio (3:1) in a gas turbine airfoil. With a given pin diameter, D=6.35 mm=[1/4]E, three different pin-fin height-to-diameter ratios, H/D=4, 3, and 2, were examined. Each of these three cases corresponds to a specific pin array geometry of detachment spacing (C) between the pin-tip and one of the endwalls, i.e., C/O=0, 1, 2, respectively. The rib height-to-channel height ratio is 0.0625.more » Two newly proposed cross ribs, namely the broken rib and full rib are evaluated in this effort. The broken ribs are positioned in between two consecutive rows of pin-fins, while the full ribs are fully extended adjacent to the pin-fins. The Reynolds number, based on the hydraulic diameter of the unobstructed cross section and the mean bulk velocity, ranges from 10,000 to 25,000. The experiment employs a hybrid technique based on transient liquid crystal imaging to obtain distributions of the local heat transfer coefficient over all of the participating surfaces, including the endwalls and all pin elements. The presence of ribs enhances local heat transfer coefficient on the endwall substantially by approximately 20% to 50% as compared to the neighboring endwall. In addition, affected by the rib geometry, which is a relatively low profile as compared to the overall height of the channel, the pressure loss seems to be insensitive to the presence of the ribs. However, from the overall heat transfer enhancement standpoint, the baseline cases (without ribs) outperform cases with broken ribs or full ribs.« less

  8. Intrathoracic migration of an unbent Steinmann pin

    PubMed Central

    R, Estfan; S, Sarkar

    2014-01-01

    Steinmann pins are known to be used as a shoulder stabilisation device in recurrent dislocation. Although rare, their potential to migrate within the thorax has been reported. We present the case of an 87-year-old man who was treated for recurrent left shoulder dislocation with pinning using a Steinmann pin. He presented eight days postoperatively with the pin impaling the aortic adventitia. To our knowledge, this is only the fifth case report of such an event. Awareness of this complication and attempts to prevent its occurrence are critical as the outcome can be fatal. PMID:24780661

  9. Optimization of geometric parameters of heat exchange pipes pin finning

    NASA Astrophysics Data System (ADS)

    Akulov, K. A.; Golik, V. V.; Voronin, K. S.; Zakirzakov, A. G.

    2018-05-01

    The work is devoted to optimization of geometric parameters of the pin finning of heat-exchanging pipes. Pin fins were considered from the point of view of mechanics of a deformed solid body as overhang beams with a uniformly distributed load. It was found out under what geometric parameters of the nib (diameter and length); the stresses in it from the influence of the washer fluid will not exceed the yield strength of the material (aluminum). Optimal values of the geometric parameters of nibs were obtained for different velocities of the medium washed by them. As a flow medium, water and air were chosen, and the cross section of the nibs was round and square. Pin finning turned out to be more than 3 times more compact than circumferential finning, so its use makes it possible to increase the number of fins per meter of the heat-exchanging pipe. And it is well-known that this is the main method for increasing the heat transfer of a convective surface, giving them an indisputable advantage.

  10. Generation of plate tectonics via grain-damage and pinning

    NASA Astrophysics Data System (ADS)

    Bercovici, D.; Ricard, Y. R.

    2012-12-01

    Weakening and shear localization in the lithosphere are essential ingredients for understanding how and whether plate tectonics is generated from mantle convection on terrestrial planets. The grain-damage and pinning mechanism of Bercovici & Ricard (2012) for lithospheric shear--localization proposes that damage to the interface between phases in a polycrystalline material like peridotite (composed primarily of olivine and pyroxene) increases the number of small Zener pinning surfaces that constrain mineral grains to ever smaller sizes regardless of creep mechanism. This effect allows a self-softening feedback in which damage and grain-reduction can co-exist with a grain-size dependent diffusion creep rheology; moreoever, grain growth and weak-zone healing are greatly impeded by Zener pinning thereby leading to long-lived relic weak zones. This mechanism is employed in two-dimensional flow calculations to test its ability to generate toroidal (strike-slip) motion from convective type flow and to influence plate evolution. The fluid dynamical calculations employ source-sink driven flow as a proxy for convective poloidal flow (upwelling/downwelling and divergent/convergent motion), and the coupling of this flow with non-linear rheological mechanisms excites toroidal or strike-slip motion. The numerical experiments show that pure dislocation-creep rheology, and grain-damage without Zener pinning (as occurs in a single-phase assemblages) permit only weak localization and toroidal flow; however, the full grain-damage with pinning readily allows focussed localization and intense, plate-like toroidal motion and strike-slip deformation. Rapid plate motion changes are also tested with abrupt rotations of the source-sink field after a plate-like configuration is developed; the post-rotation flow and material property fields are found to never recover or lose memory of the original configuration, leading to suboptimally aligned plate boundaries (e.g., strike-slip margins non

  11. WRKY23 is a component of the transcriptional network mediating auxin feedback on PIN polarity

    PubMed Central

    Vasileva, Mina; Sauer, Michael

    2018-01-01

    Auxin is unique among plant hormones due to its directional transport that is mediated by the polarly distributed PIN auxin transporters at the plasma membrane. The canalization hypothesis proposes that the auxin feedback on its polar flow is a crucial, plant-specific mechanism mediating multiple self-organizing developmental processes. Here, we used the auxin effect on the PIN polar localization in Arabidopsis thaliana roots as a proxy for the auxin feedback on the PIN polarity during canalization. We performed microarray experiments to find regulators of this process that act downstream of auxin. We identified genes that were transcriptionally regulated by auxin in an AXR3/IAA17- and ARF7/ARF19-dependent manner. Besides the known components of the PIN polarity, such as PID and PIP5K kinases, a number of potential new regulators were detected, among which the WRKY23 transcription factor, which was characterized in more detail. Gain- and loss-of-function mutants confirmed a role for WRKY23 in mediating the auxin effect on the PIN polarity. Accordingly, processes requiring auxin-mediated PIN polarity rearrangements, such as vascular tissue development during leaf venation, showed a higher WRKY23 expression and required the WRKY23 activity. Our results provide initial insights into the auxin transcriptional network acting upstream of PIN polarization and, potentially, canalization-mediated plant development. PMID:29377885

  12. Study of Charge Transport in Vertically Aligned Nitride Nanowire Based Core Shell P-I-N Junctions

    DTIC Science & Technology

    2016-07-01

    Vertically- Aligned Nitride Nanowire Based Core Shell P-I-N Junctions Distribution Statement A. Approved for public release; distribution is...Study of Charge Transport in Vertically- Aligned Nitride Nanowire Based Core Shell P-I-N Junctions Grant Number: HDTRA1-14-1-0003 Principal...Investigator: Abhishek Motayed University of Maryland DISTRIBUTION A: Public Release Study of Charge Transport in Vertically-Aligned Nitride Nanowire

  13. 22 CFR 228.03 - Identification of principal geographic code numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Identification of principal geographic code numbers. 228.03 Section 228.03 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON SOURCE, ORIGIN AND NATIONALITY FOR COMMODITIES AND SERVICES FINANCED BY USAID Definitions and Scope of This Part...

  14. Plastic Clamp Retains Clevis Pin

    NASA Technical Reports Server (NTRS)

    Cortes, R. G.

    1983-01-01

    Plastic clamp requires no special installation or removal tools. Clamp slips easily over end of pin. Once engaged in groove, holds pin securely. Installed and removed easily without special tools - screwdriver or putty knife adequate for prying out of groove. Used to retain bearings, rollers pulleys, other parts that rotate. Applications include slowly and intermittently rotating parts in appliances.

  15. Length scales and pinning of interfaces

    PubMed Central

    Tan, Likun

    2016-01-01

    The pinning of interfaces and free discontinuities by defects and heterogeneities plays an important role in a variety of phenomena, including grain growth, martensitic phase transitions, ferroelectricity, dislocations and fracture. We explore the role of length scale on the pinning of interfaces and show that the width of the interface relative to the length scale of the heterogeneity can have a profound effect on the pinning behaviour, and ultimately on hysteresis. When the heterogeneity is large, the pinning is strong and can lead to stick–slip behaviour as predicted by various models in the literature. However, when the heterogeneity is small, we find that the interface may not be pinned in a significant manner. This shows that a potential route to making materials with low hysteresis is to introduce heterogeneities at a length scale that is small compared with the width of the phase boundary. Finally, the intermediate setting where the length scale of the heterogeneity is comparable to that of the interface width is characterized by complex interactions, thereby giving rise to a non-monotone relationship between the relative heterogeneity size and the critical depinning stress. PMID:27002068

  16. Three-dimensional pin-to-pin analyses of VVER-440 cores by the MOBY-DICK code

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lehmann, M.; Mikolas, P.

    1994-12-31

    Nuclear design for the Dukovany (EDU) VVER-440s nuclear power plant is routinely performed by the MOBY-DICK system. After its implementation on Hewlett Packard series 700 workstations, it is able to perform routinely three-dimensional pin-to-pin core analyses. For purposes of code validation, the benchmark prepared from EDU operational data was solved.

  17. The effect of temperature on pinning mechanisms in HTS composites

    NASA Astrophysics Data System (ADS)

    Sotnikova, A. P.; Rudnev, I. A.

    2016-09-01

    Pinning mechanism in samples of second generation tapes (2G) of high-temperature superconductors (HTS) was studied The critical current and the pinning force were calculated from the magnetization curves measured in the temperature range of 4.2 - 77 K in magnetic fields up to 14 Tesla using vibration sample magnetometer. To determine the pinning mechanism the dependences of pinning force on magnetic field were constructed according to the Dew-Hughes model and Kramer's rule. The obtained dependences revealed a significant influence of the temperature on effectiveness of different types of pinning. At low temperatures the 2G HTS tapes of different manufacturers demonstrated an equal efficiency of the pinning centers but with temperature increase the differences in pinning mechanisms as well as in properties and effectiveness of the pinning centers become obvious. The influence of the pinning mechanism on the energy losses in HTS tapes was shown.

  18. 24 CFR 884.117 - Disclosure and verification of Social Security and Employer Identification Numbers by owners.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers by owners. 884.117 Section 884.117 Housing and Urban... PROJECTS Applicability, Scope and Basic Policies § 884.117 Disclosure and verification of Social Security... Social Security and Employer Identification Numbers, as provided by 24 CFR part 5. (Approved by the...

  19. Vortex pinning landscape in MOD-TFA YBCO nanostroctured films

    NASA Astrophysics Data System (ADS)

    Gutierrez, J.; Puig, T.; Pomar, A.; Obradors, X.

    2008-03-01

    A methodology of general validity to study vortex pinning in YBCO based on Jc transport measurements is described. It permits to identify, separate and quantify three basic vortex pinning contributions associated to anisotropic-strong, isotropic-strong and isotropic-weak pinning centers. Thereof, the corresponding vortex pinning phase diagrams are built up. This methodology is applied to the new solution-derived YBCO nanostructured films, including controlled interfacial pinning by the growth of nanostructured templates by means of self-assembled processes [1] and YBCO-BaZrO3 nanocomposites prepared by modified solution precursors. The application of the methodology and comparison with a standard solution-derived YBCO film [2], enables us to identify the nature and the effect of the additional pinning centers induced. The nanostructured templates films show c-axis pinning strongly increased, controlling most of the pinning phase diagram. On the other hand, the nanocomposites have achieved so far, the highest pinning properties in HTc-superconductors [3], being the isotropic-strong defects contribution the origin of their unique properties. [1] M. Gibert et al, Adv. Mat. vol 19, p. 3937 (2007) [2] Puig.T et al, SuST EUCAS 2007 (to be published) [3] J. Gutierrez et al, Nat. Mat. vol. 6, p. 367 (2007) * Work supported by HIPERCHEM, NANOARTIS and MAT2005-02047

  20. Flux pinning in yttrium barium copper oxide coated conductors

    NASA Astrophysics Data System (ADS)

    Chen, Zhijun

    High quality high-temperature-superconducting YBa2Cu 3O7-x (YBCO) films for industrial applications demand very high critical current densities Jc, which can only be achieved by strong three-dimensional (3D) pinning with deliberately introduced nano-precipitates. The purpose of this thesis is to provide an in-depth understanding of the 3D pinning in such YBCO films. In pulsed laser deposition (PLD) prepared YBCO films, a high density of anti-phase boundaries and stacking faults were found to be effective pinning defects for improving Jc in small fields. However, their failure to improve Jc at high fields shows that such naturally generated defects are not strong 3D pinning centers. A demonstration of strong 3D pinning was found in a metal organic chemical vapor deposition (MOCVD) grown YBCO coated conductor (CC) with a high density of (Y,Sm)2O3 nano-precipitates. We observed a significantly enhanced irreversibility field Hirr which, like other superconducting properties was independent of thickness, due to strong vortex-pin interactions. The advantage of 3D pinning was further illustrated by a bi-layer metalorganic deposition (MOD) grown YBCO CC with different 3D pinning structures in each layer. The Jc anisotropy of the bilayer was found to be the thickness-weighted sum of the anisotropy of the two individual layers, demonstrating an applicable way to tune the Jcanisotropy. Moreover, extensive low temperature and high magnetic field evaluations performed on an MOCVD CC with dense 3D (Y,Sm) 2O3 nano-precipitate pinning centers showed that its strong vortex pinning at 77 K correlated well to strong performance at 4.2 K too. YBCO films with quantitatively controlled artificial Y2O 3 nano-precipitates were also grown by PLD, and characterized over wide temperature and field ranges. Their Jc was found to be determined by the vortex pinning mediated by thermal fluctuation effects. In weak thermal-fluctuation situations Jc increased with decreasing effective precipitate

  1. Spatial homogenization methods for pin-by-pin neutron transport calculations

    NASA Astrophysics Data System (ADS)

    Kozlowski, Tomasz

    For practical reactor core applications low-order transport approximations such as SP3 have been shown to provide sufficient accuracy for both static and transient calculations with considerably less computational expense than the discrete ordinate or the full spherical harmonics methods. These methods have been applied in several core simulators where homogenization was performed at the level of the pin cell. One of the principal problems has been to recover the error introduced by pin-cell homogenization. Two basic approaches to treat pin-cell homogenization error have been proposed: Superhomogenization (SPH) factors and Pin-Cell Discontinuity Factors (PDF). These methods are based on well established Equivalence Theory and Generalized Equivalence Theory to generate appropriate group constants. These methods are able to treat all sources of error together, allowing even few-group diffusion with one mesh per cell to reproduce the reference solution. A detailed investigation and consistent comparison of both homogenization techniques showed potential of PDF approach to improve accuracy of core calculation, but also reveal its limitation. In principle, the method is applicable only for the boundary conditions at which it was created, i.e. for boundary conditions considered during the homogenization process---normally zero current. Therefore, there exists a need to improve this method, making it more general and environment independent. The goal of proposed general homogenization technique is to create a function that is able to correctly predict the appropriate correction factor with only homogeneous information available, i.e. a function based on heterogeneous solution that could approximate PDFs using homogeneous solution. It has been shown that the PDF can be well approximated by least-square polynomial fit of non-dimensional heterogeneous solution and later used for PDF prediction using homogeneous solution. This shows a promise for PDF prediction for off

  2. Blind identification of the number of sub-carriers for orthogonal frequency division multiplexing-based elastic optical networking

    NASA Astrophysics Data System (ADS)

    Zhao, Lei; Xu, Hengying; Bai, Chenglin

    2018-03-01

    In orthogonal frequency division multiplexing (OFDM)-based elastic optical networking (EON), it is imperative to identify unknown parameters of OFDM-based EON signals quickly, intelligently and robustly. Because the number of sub-carriers determines the size of the sub-carriers spacing and then affects the symbol period of the OFDM and the anti-dispersion capability of the system, the identification of the number of sub-carriers has a profound effect on the identification of other key parameters of the system. In this paper, we proposed a method of number identification for sub-carriers of OFDM-based EON signals with help of high-order cyclic cumulant. The specific fourth-order cyclic cumulant exists only at the location of its sub-carriers frequencies. So the identification of the number of sub-carriers can be implemented by detecting the cyclic-frequencies. The proposed scheme in our study can be divided into three sub-stages, i.e. estimating the spectral range, calculating the high-order cyclic cumulant and identifying the number of sub-carriers. When the optical signal-to-noise ratios (OSNR) varied from 16dB to 22dB, the number of sub-carriers (64-512) was successfully identified in the experiment, and from the statistical point of view, the average identification absolute accuracy (IAAs) exceeded 94%.

  3. Inscuteable Regulates the Pins-Mud Spindle Orientation Pathway

    PubMed Central

    Mauser, Jonathon F.; Prehoda, Kenneth E.

    2012-01-01

    During asymmetric cell division, alignment of the mitotic spindle with the cell polarity axis ensures that the cleavage furrow separates fate determinants into distinct daughter cells. The protein Inscuteable (Insc) is thought to link cell polarity and spindle positioning in diverse systems by binding the polarity protein Bazooka (Baz; aka Par-3) and the spindle orienting protein Partner of Inscuteable (Pins; mPins or LGN in mammals). Here we investigate the mechanism of spindle orientation by the Insc-Pins complex. Previously, we defined two Pins spindle orientation pathways: a complex with Mushroom body defect (Mud; NuMA in mammals) is required for full activity, whereas binding to Discs large (Dlg) is sufficient for partial activity. In the current study, we have examined the role of Inscuteable in mediating downstream Pins-mediated spindle orientation pathways. We find that the Insc-Pins complex requires Gαi for partial activity and that the complex specifically recruits Dlg but not Mud. In vitro competition experiments revealed that Insc and Mud compete for binding to the Pins TPR motifs, while Dlg can form a ternary complex with Insc-Pins. Our results suggest that Insc does not passively couple polarity and spindle orientation but preferentially inhibits the Mud pathway, while allowing the Dlg pathway to remain active. Insc-regulated complex assembly may ensure that the spindle is attached to the cortex (via Dlg) before activation of spindle pulling forces by Dynein/Dynactin (via Mud). PMID:22253744

  4. Establishing the need for an engineering standard for agricultural hitch pins.

    PubMed

    Deboy, G R; Knapp, W M; Field, W E; Krutz, G W; Corum, C L

    2012-04-01

    Documented incidents have occurred in which failure or unintentional disengagement of agricultural hitch pins has contributed to property damage and personal injury. An examination of current hitch pin use on a convenience sample of farm operations in Indiana revealed a variety of non-standard, worn and damaged, and inappropriately sized hitch pins in use. Informal interviews with the farm operators confirmed that hitch pin misuse, failure, or disengagement is a relatively widespread problem that remains largely unaddressed. On-site observations also suggested a low use of hitch pin retaining devices or safety chains. A review of prior research revealed that little attention has been given to this problem, and currently no documentation allows for an estimate of the frequency or severity of losses associated with hitch pin misuse, failure, or disengagement. No specific engineering standards were found that directly applied to the design, appropriate selection, or loading capacity of agricultural hitch pins. Major suppliers of replacement hitch pins currently provide little or no information on matching hitch pin size to intended applications, and most replacement hitch pins examined were of foreign origin, with the overwhelming majority imported from China or India. These replacement hitch pins provided no specifications other than diameter, length, and, in some cases, labeling that indicated that the pins had been "heat treated. " Testing of a sample of 11 commercially available replacement hitch pins found variation along the length of the pin shaft and between individual pins in surface hardness, a potential predictor of pin failure. Examination of 17 commercially available replacement pins also revealed a variety of identifiers used to describe pin composition and fabrication methods, e.g., "heat treated." None of the pins examined provided any specifications on loading capacity. It was therefore concluded that there is a need to develop an agricultural hitch

  5. Assigning unique identification numbers to new user accounts and groups in a computing environment with multiple registries

    DOEpatents

    DeRobertis, Christopher V.; Lu, Yantian T.

    2010-02-23

    A method, system, and program storage device for creating a new user account or user group with a unique identification number in a computing environment having multiple user registries is provided. In response to receiving a command to create a new user account or user group, an operating system of a clustered computing environment automatically checks multiple registries configured for the operating system to determine whether a candidate identification number for the new user account or user group has been assigned already to one or more existing user accounts or groups, respectively. The operating system automatically assigns the candidate identification number to the new user account or user group created in a target user registry if the checking indicates that the candidate identification number has not been assigned already to any of the existing user accounts or user groups, respectively.

  6. Pin-based electrochemical glucose sensor with multiplexing possibilities.

    PubMed

    Rama, Estefanía C; Costa-García, Agustín; Fernández-Abedul, M Teresa

    2017-02-15

    This work describes the use of mass-produced stainless-steel pins as low-cost electrodes to develop simple and portable amperometric glucose biosensors. A potentiostatic three-electrode configuration device is designed using two bare pins as reference and counter electrodes, and a carbon-ink coated pin as working electrode. Conventional transparency film without any pretreatment is used to punch the pins and contain the measurement solution. The interface to the potentiostat is very simple since it is based on a commercial female connection. This electrochemical system is applied to glucose determination using a bienzymatic sensor phase (glucose oxidase/horseradish peroxidase) with ferrocyanide as electron-transfer mediator, achieving a linear range from 0.05 to 1mM. It shows analytical characteristics comparable to glucose sensors previously reported using conventional electrodes, and its application for real food samples provides good results. The easy modification of the position of the pins allows designing different configurations with possibility of performing simultaneous measurements. This is demonstrated through a specific design that includes four pin working-electrodes. Different concentrations of antibody labeled with alkaline phosphatase are immobilized on the pin-heads and after enzymatic conversion of 3-indoxylphosphate and silver nitrate, metallic silver is determined by anodic stripping voltammetry. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. a Numerical Method for Stability Analysis of Pinned Flexible Mechanisms

    NASA Astrophysics Data System (ADS)

    Beale, D. G.; Lee, S. W.

    1996-05-01

    A technique is presented to investigate the stability of mechanisms with pin-jointed flexible members. The method relies on a special floating frame from which elastic link co-ordinates are defined. Energies are easily developed for use in a Lagrange equation formulation, leading to a set of non-linear and mixed ordinary differential-algebraic equations of motion with constraints. Stability and bifurcation analysis is handled using a numerical procedure (generalized co-ordinate partitioning) that avoids the tedious and difficult task of analytically reducing the system of equations to a number equalling the system degrees of freedom. The proposed method was then applied to (1) a slider-crank mechanism with a flexible connecting rod and crank of constant rotational speed, and (2) a four-bar linkage with a flexible coupler with a constant speed crank. In both cases, a single pinned-pinned beam bending mode is employed to develop resonance curves and stability boundaries in the crank length-crank speed parameter plane. Flip and fold bifurcations are common occurrences in both mechanisms. The accuracy of the proposed method was also verified by comparison with previous experimental results [1].

  8. End-threaded intramedullary positive profile screw ended self-tapping pin (Admit pin) - A cost-effective novel implant for fixing canine long bone fractures.

    PubMed

    Chanana, Mitin; Kumar, Adarsh; Tyagi, Som Prakash; Singla, Amit Kumar; Sharma, Arvind; Farooq, Uiase Bin

    2018-02-01

    The current study was undertaken to evaluate the clinical efficacy of end-threaded intramedullary pinning for management of various long bone fractures in canines. This study was conducted in two phases, managing 25 client-owned dogs presented with different fractures. The technique of application of end-threaded intramedullary pinning in long bone fractures was initially standardized in 6 clinical patients presented with long bone fractures. In this phase, end-threaded pins of different profiles, i.e., positive and negative, were used as the internal fixation technique. On the basis of results obtained from standardization phase, 19 client-owned dogs clinically presented with different fractures were implanted with end-threaded intramedullary positive profile screw ended self-tapping pin in the clinical application phase. The patients, allocated randomly in two groups, when evaluated postoperatively revealed slight pin migration in Group-I (negative profile), which resulted in disruption of callus site causing delayed union in one case and large callus formation in other two cases whereas no pin migration was observed in Group-II (positive profile). Other observations in Group-I was reduced muscle girth and delayed healing time as compared to Group-II. In clinical application, phase 21 st and 42 nd day post-operative radiographic follow-up revealed no pin migration in any of the cases, and there was no bone shortening or fragment collapse in end-threaded intramedullary positive profile screw ended self-tapping pin. The end-threaded intramedullary positive profile screw ended self-tapping pin used for fixation of long bone fractures in canines can resist pin migration, pin breakage, and all loads acting on the bone, i.e., compression, tension, bending, rotation, and shearing to an extent with no post-operative complications.

  9. Auto-adjustable pin tool for friction stir welding

    NASA Technical Reports Server (NTRS)

    Ding, R. Jeffrey (Inventor); Oelgoetz, Peter A. (Inventor)

    1999-01-01

    An auto-adjusting pin tool for friction stir welding is presented wherein the pin tool automatically adjusts for welding materials of varying thicknesses, and the pin can be incrementally withdrawn from the workpieces thus eliminating any crater or keyhole in the weld. The inventive apparatus is comprised of a welding head housing a motor connected to a controller instrument package and an arbor supported by bearings. The arbor forms an interior cylinder and is encircled by a stationary slip ring though which are ported hydraulic passageways into the interior cylinder of the arbor such that a piston housed therein may be moved axially. Coupled to the piston is a pin tool which is treaded on its lower end and which is moveably seated in, and extending through, a shoulder housing having concave lower face. When welding, the rotating treaded end of the pin enters and stirs the workpieces while the lower face of the shoulder housing compacts the workpieces. As the welding head traverses the shoulder housing the controller senses any rising pressure on the lower face of the shoulder housing and withdraws the arbor to keep the pressure constant. At the same time, the piston moves towards the workpieces thus extending the pin further from the shoulder. This keeps the pin at a proper depth in the workpieces regardless of their thicknesses. As the weld terminates this same operation can be used to incrementally withdraw the pin during the final part of the traverse, thus eliminating any keyhole or crater that would otherwise be created.

  10. Retractable Pin Tools for the Friction Stir Welding Process

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Two companies have successfully commercialized a specialized welding tool developed at the Marshall Space Flight Center (MSFC). Friction stir welding uses the high rotational speed of a tool and the resulting frictional heat created from contact to crush, 'stir' together, and forge a bond between two metal alloys. It has had a major drawback, reliance on a single-piece pin tool. The pin is slowly plunged into the joint between two materials to be welded and rotated as high speed. At the end of the weld, the single-piece pin tool is retracted and leaves a 'keyhole,' something which is unacceptable when welding cylindrical objects such as drums, pipes and storage tanks. Another drawback is the requirement for different-length pin tools when welding materials of varying thickness. An engineer at the MSFC helped design an automatic retractable pin tool that uses a computer-controlled motor to automatically retract the pin into the shoulder of the tool at the end of the weld, preventing keyholes. This design allows the pin angle and length to be adjusted for changes in material thickness and results in a smooth hole closure at the end of the weld. Benefits of friction stir welding, using the MSFC retractable pin tool technology, include the following: The ability to weld a wide range of alloys, including previously unweldable and composite materials; provision of twice the fatigue resistance of fusion welds and no keyholes; minimization of material distortion; no creation of hazards such as welding fumes, radiation, high voltage, liquid metals, or arcing; automatic retraction of the pin at the end of the weld; and maintaining full penetration of the pin.

  11. Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin

    PubMed Central

    Nakamura, Kazuhiro; Kosugi, Isao; Lee, Daniel Y.; Hafner, Angela; Sinclair, David A.

    2012-01-01

    The Wnt/β-catenin pathway promotes proliferation of neural progenitor cells (NPCs) at early stages and induces neuronal differentiation from NPCs at late stages, but the molecular mechanisms that control this stage-specific response are unclear. Pin1 is a prolyl isomerase that regulates cell signaling uniquely by controlling protein conformation after phosphorylation, but its role in neuronal differentiation is not known. Here we found that whereas Pin1 depletion suppresses neuronal differentiation, Pin1 overexpression enhances it, without any effects on gliogenesis from NPCs in vitro. Consequently, Pin1-null mice have significantly fewer upper layer neurons in the motor cortex and severely impaired motor activity during the neonatal stage. A proteomic approach identified β-catenin as a major substrate for Pin1 in NPCs, in which Pin1 stabilizes β-catenin. As a result, Pin1 knockout leads to reduced β-catenin during differentiation but not proliferation of NPCs in developing brains. Importantly, defective neuronal differentiation in Pin1 knockout NPCs is fully rescued in vitro by overexpression of β-catenin but not a β-catenin mutant that fails to act as a Pin1 substrate. These results show that Pin1 is a novel regulator of NPC differentiation by acting on β-catenin and provides a new postphosphorylation signaling mechanism to regulate developmental stage-specific functioning of β-catenin signaling in neuronal differentiation. PMID:22645310

  12. Vortex pinning properties in Fe-chalcogenides

    NASA Astrophysics Data System (ADS)

    Leo, A.; Grimaldi, G.; Guarino, A.; Avitabile, F.; Nigro, A.; Galluzzi, A.; Mancusi, D.; Polichetti, M.; Pace, S.; Buchkov, K.; Nazarova, E.; Kawale, S.; Bellingeri, E.; Ferdeghini, C.

    2015-12-01

    Among the families of iron-based superconductors, the 11-family is one of the most attractive for high field applications at low temperatures. Optimization of the fabrication processes for bulk, crystalline and/or thin film samples is the first step in producing wires and/or tapes for practical high power conductors. Here we present the results of a comparative study of pinning properties in iron-chalcogenides, investigating the flux pinning mechanisms in optimized Fe(Se{}1-xTe x ) and FeSe samples by current-voltage characterization, magneto-resistance and magnetization measurements. In particular, from Arrhenius plots in magnetic fields up to 9 T, the activation energy is derived as a function of the magnetic field, {U}0(H), whereas the activation energy as a function of temperature, U(T), is derived from relaxation magnetization curves. The high pinning energies, high upper critical field versus temperature slopes near critical temperatures, and highly isotropic pinning properties make iron-chalcogenide superconductors a technological material which could be a real competitor to cuprate high temperature superconductors for high field applications.

  13. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation

    PubMed Central

    Zhang, Yingjie; Rai, Madhulika; Wang, Cheng; Gonzalez, Cayetano; Wang, Hongyan

    2016-01-01

    Prefoldin is a molecular chaperone complex that regulates tubulin function in mitosis. Here, we show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Interestingly, co-depletion of Prefoldin and Partner of Inscuteable (Pins) leads to the formation of gigantic brains with severe neuroblast overgrowth, despite that Pins depletion alone results in smaller brains with partially disrupted neuroblast polarity. We show that Prefoldin acts synergistically with Pins to regulate asymmetric division of both neuroblasts and Intermediate Neural Progenitors (INPs). Surprisingly, co-depletion of Prefoldin and Pins also induces dedifferentiation of INPs back into neuroblasts, while depletion either Prefoldin or Pins alone is insufficient to do so. Furthermore, knocking down either α-tubulin or β-tubulin in pins- mutant background results in INP dedifferentiation back into neuroblasts, leading to the formation of ectopic neuroblasts. Overexpression of α-tubulin suppresses neuroblast overgrowth observed in prefoldin pins double mutant brains. Our data elucidate an unexpected function of Prefoldin and Pins in synergistically suppressing dedifferentiation of INPs back into neural stem cells. PMID:27025979

  14. 24 CFR 5.218 - Penalties for failing to disclose and verify Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Penalties for failing to disclose and verify Social Security and Employer Identification Numbers. 5.218 Section 5.218 Housing and Urban....218 Penalties for failing to disclose and verify Social Security and Employer Identification Numbers...

  15. 24 CFR 5.218 - Penalties for failing to disclose and verify Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Penalties for failing to disclose and verify Social Security and Employer Identification Numbers. 5.218 Section 5.218 Housing and Urban....218 Penalties for failing to disclose and verify Social Security and Employer Identification Numbers...

  16. 24 CFR 5.218 - Penalties for failing to disclose and verify Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Penalties for failing to disclose and verify Social Security and Employer Identification Numbers. 5.218 Section 5.218 Housing and Urban....218 Penalties for failing to disclose and verify Social Security and Employer Identification Numbers...

  17. 24 CFR 5.218 - Penalties for failing to disclose and verify Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Penalties for failing to disclose and verify Social Security and Employer Identification Numbers. 5.218 Section 5.218 Housing and Urban....218 Penalties for failing to disclose and verify Social Security and Employer Identification Numbers...

  18. 24 CFR 5.218 - Penalties for failing to disclose and verify Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Penalties for failing to disclose and verify Social Security and Employer Identification Numbers. 5.218 Section 5.218 Housing and Urban....218 Penalties for failing to disclose and verify Social Security and Employer Identification Numbers...

  19. Involvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells.

    PubMed

    Risal, Prabodh; Shrestha, Nirajan; Chand, Lokendra; Sylvester, Karl G; Jeong, Yeon Jun

    2017-04-01

    Liver regenerates remarkably after toxic injury or surgical resection. In the case of failure of resident hepatocytes to restore loss, repopulation is carried out by induction, proliferation, and differentiation of the progenitor cell. Although, some signaling pathways have been verified to contribute oval cell-mediated liver regeneration, role of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Pin1) in the oval cells proliferation is unknown. In the present study, we evaluate the role of Pin1 in oval cells proliferation. In our study, the expression of Pin1 in the mice liver increased after three weeks feeding of 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) diet along with the proliferation of oval cells. The expression of Pin1 was higher in oval cells compared to the hepatocytes.Pin1 inhibition by Juglone reduced oval cell proliferation, which was restored to normal when oval cells were treated with IGF-1. Consistent with increased cell growth, expression of Pin1, β-catenin and PCNA were increased in IGF-1 treated cells in a time dependent manner. In FACS analysis, siRNA-mediated knockdown of the Pin1 protein in the oval cells significantly increased the numbers of cells in G0/G1 phase. Furthermore, hepatocyte when treated with TGF-β showed marked reduction in cell proliferation and expression of Pin1 whereas this effect was not seen in the oval cells treated with TGF-β. In conclusion, Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury. Copyright © 2017 Elsevier GmbH. All rights reserved.

  20. The "Good, Bad and Ugly" pin site grading system: A reliable and memorable method for documenting and monitoring ring fixator pin sites.

    PubMed

    Clint, S A; Eastwood, D M; Chasseaud, M; Calder, P R; Marsh, D R

    2010-02-01

    Although there is much in the literature regarding pin site infections, there is no accepted, validated method for documenting their state. We present a system for reliably labelling pin sites on any ring fixator construct and an easy-to-remember grading system to document the state of each pin site. Each site is graded in terms of erythema, pain and discharge to give a 3-point scale, named "Good", "Bad" and "Ugly" for ease of recall. This system was tested for intra- and inter-observer reproducibility. 15 patients undergoing elective limb reconstruction were recruited. A total of 218 pin sites were independently scored by 2 examiners. 82 were then re-examined later by the same examiners. 514 pin sites were felt to be "Good", 80 "Bad" and 6 "Ugly". The reproducibility of the system was found to be excellent. We feel our system gives a quick, reliable and reproducible method to monitor individual pin sites and their response to treatment. Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.

  1. Retractable pin dual in-line package test clip

    DOEpatents

    Bandzuch, Gregory S.; Kosslow, William J.

    1996-01-01

    This invention is a Dual In-Line Package (DIP) test clip for use when troubleshooting circuits containing DIP integrated circuits. This test clip is a significant improvement over existing DIP test clips in that it has retractable pins which will permit troubleshooting without risk of accidentally shorting adjacent pins together when moving probes to different pins on energized circuits or when the probe is accidentally bumped while taking measurements.

  2. A pin-assisted retention technique for resin-bonded restorations.

    PubMed

    Miara, P; Touati, B

    1992-09-01

    The value of pins for auxiliary retention has been demonstrated many times. The use of pins with resin-bonded restorations allows for improved aesthetics and less tooth reduction while increasing resistance to dislodging forces. Clinical and technical procedures for resin-bonded bridges with pin-assisted retention are presented.

  3. Effective vortex pinning in MgB2 thin films

    NASA Astrophysics Data System (ADS)

    Bugoslavsky, Y.; Cowey, L.; Tate, T. J.; Perkins, G. K.; Moore, J.; Lockman, Z.; Berenov, A.; MacManus-Driscoll, J. L.; Caplin, A. D.; Cohen, L. F.; Zhai, H. Y.; Christen, H. M.; Paranthaman, M. P.; Lowndes, D. H.; Jo, M. H.; Blamire, M. G.

    2002-10-01

    We discuss the pinning properties of MgB2 thin films grown by pulsed-laser deposition (PLD) and by electron-beam (EB) evaporation. Two mechanisms are identified that contribute most effectively to the pinning of vortices in randomly oriented films. The EB process produces low defected crystallites with a small grain size providing enhanced pinning at grain boundaries without any degradation of Tc. The PLD process produces films with structural disorder on a scale less than the coherence length that further improves pinning, but also depresses Tc.

  4. System for Controlling the Stirring Pin of a Friction Stir Welding Apparatus

    NASA Technical Reports Server (NTRS)

    Ding, R. Jeffrey (Inventor); Romine, Peter L. (Inventor); Oelgoetz, Peter A. (Inventor)

    2002-01-01

    A control is provided for a friction stir welding apparatus comprising a pin tool which includes a shoulder and a rotating pin extending outwardly from the shoulder of the pin tool and which, in use, is plunged into a workpiece formed contacting workpiece members to stir weld the members together. The control system controls the penetration of the pin tool into the workpiece members which are mounted on a support anvil. The control system includes a pin length controller for controlling pin length relative to the shoulder and for producing a corresponding pin length signal. A pin force sensor senses the force being exerted on the pin during welding and produces a corresponding actual pin force signal. A probe controller controls a probe extending outwardly from the pin, senses a parameter related to the distance between the probe and the supporting anvil and produces a corresponding probe signal. A workpiece standoff sensor senses the standoff distance between the workpiece and the standoff sensor and produces a corresponding standoff signal. A control unit receives the various signals, together with a weld schedule, and, based on these signals and the weld schedule, controls the pin length controller so as to control pin penetration into the workpiece.

  5. Complications after pinning of supracondylar distal humerus fractures.

    PubMed

    Bashyal, Ravi K; Chu, Jennifer Y; Schoenecker, Perry L; Dobbs, Matthew B; Luhmann, Scott J; Gordon, J Eric

    2009-01-01

    Supracondylar distal humerus fractures are one of the most common skeletal injuries in children. The current treatment of choice in North America is closed reduction and percutaneous pin fixation. Often surgeons leave the pins exposed beneath a cast but outside the skin. Great variation exists with respect to preoperative skin preparation, and perioperative antibiotic administration. Few data exist regarding the rate of infection and other complications. The purpose of this study is to review a large series of children to evaluate the rate of infection and other complications. A retrospective review was carried out of all patients treated at our institution over an 11-year period. A total of 622 patients were identified that were followed for a minimum of 2 weeks after pin removal. Seventeen patients had flexion-type fractures, 294 had type II fractures, and 311 had type III fractures. Seventy-four fractures (11.9%) had preoperative nerve deficits with anterior interosseous palsies being the most common (33 fractures, 5.3%). Preoperative antibiotics were given to 163 patients (26.2%). Spray and towel draping were used in 362 patients, paint and towel draping were used in 65 patients, alcohol paint and towel draping were used in 146 patients, and a full preparation and draping were used in 13 patients. The pins were left exposed under the cast in 591 fractures (95%), and buried beneath the skin in 31 fractures (5.0%). A medial pin was placed in 311 fractures with a small incision made to aid placement in 18 of these cases. The most common complication was pin migration necessitating unexpected return to the operating room for pin removal in 11 patients (1.8%). One patient developed a deep infection with septic arthritis and osteomyelitis (0.2%). Five additional patients had superficial skin infections and were treated with oral antibiotics for a total infection rate of 6 of 622 patients (1.0%). One patient ultimately had a malunion and 4 others returned to the

  6. Connection stiffness and dynamical docking process of flux pinned spacecraft modules

    NASA Astrophysics Data System (ADS)

    Lu, Yong; Zhang, Mingliang; Gao, Dong

    2014-02-01

    This paper describes a novel kind of potential flux pinned docking system that consists of guidance navigation and control system, the traditional extrusion type propulsion system, and a flux pinned docking interface. Because of characteristics of passive stability of flux pinning, the docking control strategy of flux pinned docking system only needs a series of sequential control rather than necessary active feedback control, as well as avoidance of hazardous collision accident. The flux pinned force between YBaCuO (YBCO) high temperature superconductor bulk and permanent magnet is able to be given vent based on the identical current loop model and improved image dipole model, which can be validated experimentally. Thus, the connection stiffness between two flux pinned spacecraft modules can be calculated based on Hooke's law. This connection stiffness matrix at the equilibrium position has the positive definite performance, which can validate the passively stable connection of two flux pinned spacecraft modules theoretically. Furthermore, the relative orbital dynamical equation of two flux pinned spacecraft modules can be established based on Clohessy-Wiltshire's equations and improved image dipole model. The dynamical docking process between two flux pinned spacecraft modules can be obtained by way of numerical simulation, which suggests the feasibility of flux pinned docking system.

  7. Connection stiffness and dynamical docking process of flux pinned spacecraft modules

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Yong; Zhang, Mingliang, E-mail: niudun12@126.com; Gao, Dong

    2014-02-14

    This paper describes a novel kind of potential flux pinned docking system that consists of guidance navigation and control system, the traditional extrusion type propulsion system, and a flux pinned docking interface. Because of characteristics of passive stability of flux pinning, the docking control strategy of flux pinned docking system only needs a series of sequential control rather than necessary active feedback control, as well as avoidance of hazardous collision accident. The flux pinned force between YBaCuO (YBCO) high temperature superconductor bulk and permanent magnet is able to be given vent based on the identical current loop model and improvedmore » image dipole model, which can be validated experimentally. Thus, the connection stiffness between two flux pinned spacecraft modules can be calculated based on Hooke's law. This connection stiffness matrix at the equilibrium position has the positive definite performance, which can validate the passively stable connection of two flux pinned spacecraft modules theoretically. Furthermore, the relative orbital dynamical equation of two flux pinned spacecraft modules can be established based on Clohessy-Wiltshire's equations and improved image dipole model. The dynamical docking process between two flux pinned spacecraft modules can be obtained by way of numerical simulation, which suggests the feasibility of flux pinned docking system.« less

  8. Accurate identification of layer number for few-layer WS2 and WSe2 via spectroscopic study.

    PubMed

    Li, Yuanzheng; Li, Xinshu; Yu, Tong; Yang, Guochun; Chen, Heyu; Zhang, Cen; Feng, Qiushi; Ma, Jiangang; Liu, Weizhen; Xu, Haiyang; Liu, Yichun; Liu, Xinfeng

    2018-03-23

    Transition metal dichalcogenides (TMDs) with a typical layered structure are highly sensitive to their layer number in optical and electronic properties. Seeking a simple and effective method for layer number identification is very important to low-dimensional TMD samples. Herein, a rapid and accurate layer number identification of few-layer WS 2 and WSe 2 is proposed via locking their photoluminescence (PL) peak-positions. As the layer number of WS 2 /WSe 2 increases, it is found that indirect transition emission is more thickness-sensitive than direct transition emission, and the PL peak-position differences between the indirect and direct transitions can be regarded as fingerprints to identify their layer number. Theoretical calculation confirms that the notable thickness-sensitivity of indirect transition derives from the variations of electron density of states of W atom d-orbitals and chalcogen atom p-orbitals. Besides, the PL peak-position differences between the indirect and direct transitions are almost independent of different insulating substrates. This work not only proposes a new method for layer number identification via PL studies, but also provides a valuable insight into the thickness-dependent optical and electronic properties of W-based TMDs.

  9. Digital Rise-Time Discrimination of Pulses from the Tigress Integrated Plunger Silicon PIN Diode Wall

    NASA Astrophysics Data System (ADS)

    Voss, P.; Henderson, R.; Andreoiu, C.; Ashley, R.; Ball, G. C.; Bender, P. C.; Chester, A.; Cross, D. S.; Drake, T. E.; Garnsworthy, A. B.; Hackman, G.; Ketelhut, S.; Krücken, R.; Miller, D.; Rajabali, M. M.; Starosta, K.; Svensson, C. E.; Tardiff, E.; Unsworth, C.; Wang, Z.-M.

    Electromagnetic transition rate measurements play an important role in characterizing the evolution of nuclear structure with increasing proton-neutron asymmetry. At TRIUMF, the TIGRESS Integrated Plunger device and its suite of ancillary detector systems have been implemented for charged-particle tagging and light-ion identification in coincidence with gamma-ray spectroscopy for Doppler-shift lifetime studies and low-energy Coulomb excitation measurements. Digital pulse-shape analysis of signals from these ancillary detectors for particle identification improves the signal-to-noise ratio of gamma-ray energy spectra. Here, we illustrate the reaction-channel selectivity achieved by utilizing digital rise-time discrimination of waveforms from alpha particles and carbon ions detected with silicon PIN diodes, thereby enhancing gamma-ray line-shape signatures for precision lifetime studies.

  10. Analysis of geometric moments as features for firearm identification.

    PubMed

    Md Ghani, Nor Azura; Liong, Choong-Yeun; Jemain, Abdul Aziz

    2010-05-20

    The task of identifying firearms from forensic ballistics specimens is exacting in crime investigation since the last two decades. Every firearm, regardless of its size, make and model, has its own unique 'fingerprint'. These fingerprints transfer when a firearm is fired to the fired bullet and cartridge case. The components that are involved in producing these unique characteristics are the firing chamber, breech face, firing pin, ejector, extractor and the rifling of the barrel. These unique characteristics are the critical features in identifying firearms. It allows investigators to decide on which particular firearm that has fired the bullet. Traditionally the comparison of ballistic evidence has been a tedious and time-consuming process requiring highly skilled examiners. Therefore, the main objective of this study is the extraction and identification of suitable features from firing pin impression of cartridge case images for firearm recognition. Some previous studies have shown that firing pin impression of cartridge case is one of the most important characteristics used for identifying an individual firearm. In this study, data are gathered using 747 cartridge case images captured from five different pistols of type 9mm Parabellum Vektor SP1, made in South Africa. All the images of the cartridge cases are then segmented into three regions, forming three different set of images, i.e. firing pin impression image, centre of firing pin impression image and ring of firing pin impression image. Then geometric moments up to the sixth order were generated from each part of the images to form a set of numerical features. These 48 features were found to be significantly different using the MANOVA test. This high dimension of features is then reduced into only 11 significant features using correlation analysis. Classification results using cross-validation under discriminant analysis show that 96.7% of the images were classified correctly. These results demonstrate

  11. Detail of "pin" or large bolt used to assemble the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail of "pin" or large bolt used to assemble the truss pieces. This "pin" is on pony truss; similar pins were used on movable span. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  12. Testing of the KRI-developed Silicon PIN Radioxenon Detector

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Foxe, Michael P.; McIntyre, Justin I.

    within the cell, which will need to be explored in future work. A third important parameter in choosing the best detection technique for radioxenon is the resolution of the electron detection. While the resolution is important in determining the minimum detectable concentration, it plays a larger role in source identification when there is a visible signal. The Silicon PIN diodes generated improved resolution over a similar plastic scintillator cell. With the improved resolution, it becomes easier to distinguish the radioxenon isomers ( 133mXe and 131mXe) from the 133Xe beta continuum background. With the beta background from 133Xe ever present with the detection of the isomers, the improved resolution proves vital in calculating the ratios of the three isotopes. With an accurate measurement of the isotopic ratios, the anthropogenic sources of radioxenon (medical isotope production and nuclear reactors) can be more accurately distinguished. Based on the results shown within this report, a Si PIN beta cell shows the potential to aid in the operation and discriminating power of the IMS for the CTBTO. However, there are a number of issues that need attention before a detector of this design would be reliable enough for field operations in the IMS. Issues that need develop include, but are not limited to: studying the robustness of the design in field conditions, eliminating or minimizing the noise and variability of individual Si detector elements, understanding the long-term gain stability of the Si detectors, and reducing the non-Si materials within the cell (i.e. the plastic housing).« less

  13. Study of Damped Set-Back Pins for S and A Mechanisms.

    DTIC Science & Technology

    1976-11-01

    arm device for artillery munitions. This damped set-back pin assembly is one of two safety features on a S and A device used in the M739 PD/XM587 ET...The damped set-back pin study program was for the design, testing, fabrication, and delivery and damped set-back pin assemblies for use in a safe and...fuzes for a rotating projectile. A pin, porous disc, return spring, floating O-ring, and sleeve comprise the selected damped set-back pin assembly

  14. Inactivation of Plasma Membrane–Localized CDPK-RELATED KINASE5 Decelerates PIN2 Exocytosis and Root Gravitropic Response in Arabidopsis[C][W

    PubMed Central

    Rigó, Gábor; Ayaydin, Ferhan; Tietz, Olaf; Zsigmond, Laura; Kovács, Hajnalka; Páy, Anikó; Salchert, Klaus; Darula, Zsuzsanna; Medzihradszky, Katalin F.; Szabados, László; Palme, Klaus; Koncz, Csaba; Cséplő, Ágnes

    2013-01-01

    CRK5 is a member of the Arabidopsis thaliana Ca2+/calmodulin-dependent kinase-related kinase family. Here, we show that inactivation of CRK5 inhibits primary root elongation and delays gravitropic bending of shoots and roots. Reduced activity of the auxin-induced DR5–green fluorescent protein reporter suggests that auxin is depleted from crk5 root tips. However, no tip collapse is observed and the transcription of genes for auxin biosynthesis, AUXIN TRANSPORTER/AUXIN TRANSPORTER-LIKE PROTEIN (AUX/LAX) auxin influx, and PIN-FORMED (PIN) efflux carriers is unaffected by the crk5 mutation. Whereas AUX1, PIN1, PIN3, PIN4, and PIN7 display normal localization, PIN2 is depleted from apical membranes of epidermal cells and shows basal to apical relocalization in the cortex of the crk5 root transition zone. This, together with an increase in the number of crk5 lateral root primordia, suggests facilitated auxin efflux through the cortex toward the elongation zone. CRK5 is a plasma membrane–associated kinase that forms U-shaped patterns facing outer lateral walls of epidermis and cortex cells. Brefeldin inhibition of exocytosis stimulates CRK5 internalization into brefeldin bodies. CRK5 phosphorylates the hydrophilic loop of PIN2 in vitro, and PIN2 shows accelerated accumulation in brefeldin bodies in the crk5 mutant. Delayed gravitropic response of the crk5 mutant thus likely reflects defective phosphorylation of PIN2 and deceleration of its brefeldin-sensitive membrane recycling. PMID:23673979

  15. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Subedi, Amit; Graduate School of Science and Engineering, Saitama University, Saitama, 338-8570; Shimizu, Takeshi

    2016-06-03

    Peptidyl prolyl cis/trans isomerization by Pin1 regulates various oncogenic signals during cancer progression, and its inhibition through multiple approaches has established Pin1 as a therapeutic target. However, lack of simplified screening systems has limited the discovery of potent Pin1 inhibitors. We utilized phosphorylation-dependent binding of Pin1 to its specific substrate to develop a screening system for Pin1 inhibitors. Using this system, we screened a chemical library, and identified a novel selenium derivative as Pin1 inhibitor. Based on structure-activity guided chemical synthesis, we developed more potent Pin1 inhibitors that inhibited cancer cell proliferation. -- Highlights: •Novel screening for Pin1 inhibitors basedmore » on Pin1 binding is developed. •A novel selenium compound is discovered as Pin1 inhibitor. •Activity guided chemical synthesis of selenium derivatives resulted potent Pin1 inhibitors.« less

  16. PIN architecture for ultrasensitive organic thin film photoconductors.

    PubMed

    Jin, Zhiwen; Wang, Jizheng

    2014-06-17

    Organic thin film photoconductors (OTFPs) are expected to have wide applications in the field of optical communications, artificial vision and biomedical sensing due to their great advantages of high flexibility and low-cost large-area fabrication. However, their performances are not satisfactory at present: the value of responsivity (R), the parameter that measures the sensitivity of a photoconductor to light, is below 1 AW(-1). We believe such poor performance is resulted from an intrinsic self-limited effect of present bare blend based device structure. Here we designed a PIN architecture for OTFPs, the PIN device exhibits a significantly improved high R value of 96.5 AW(-1). The PIN architecture and the performance the PIN device shows here should represent an important step in the development of OTFPs.

  17. PIN architecture for ultrasensitive organic thin film photoconductors

    PubMed Central

    Jin, Zhiwen; Wang, Jizheng

    2014-01-01

    Organic thin film photoconductors (OTFPs) are expected to have wide applications in the field of optical communications, artificial vision and biomedical sensing due to their great advantages of high flexibility and low-cost large-area fabrication. However, their performances are not satisfactory at present: the value of responsivity (R), the parameter that measures the sensitivity of a photoconductor to light, is below 1 AW−1. We believe such poor performance is resulted from an intrinsic self-limited effect of present bare blend based device structure. Here we designed a PIN architecture for OTFPs, the PIN device exhibits a significantly improved high R value of 96.5 AW−1. The PIN architecture and the performance the PIN device shows here should represent an important step in the development of OTFPs. PMID:24936952

  18. 47 CFR 3.22 - Number of accounting authority identification codes per applicant.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.22 Number of accounting authority identification codes per applicant... assign U.S. AAICs for entities settling accounts of U.S. licensed vessels in the maritime mobile and...

  19. Detail of "pin" or large bolt used to assemble the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail of "pin" or large bolt used to assemble the truss pieces. This "pin" is on pony truss; similar pins were used on movable span. - Naval Supply Annex Stockton, Daggett Road Bridge, Daggett Road traversing Burns Cut Off, Stockton, San Joaquin County, CA

  20. Biomechanical and Cost Comparisons of Near-Far and Pin-Bar Constructs.

    PubMed

    Whitney Kluk, Augusta; Zhang, Tina; Russell, Joseph P; Kim, Hyunchul; Hsieh, Adam H; O'Toole, Robert V

    2017-03-01

    Orthopedic dogma states that external fixator stiffness is improved by placing 1 pin close to the fracture and 1 as distant as possible ("near-far"). This fixator construct is thought to be less expensive than placing pins a shorter distance apart and using "pin-bar" clamps that attach pins to outriggers. The authors therefore hypothesized that the near-far construct is stiffer and less expensive. They compared mechanical stiffness and costs of near-far and pin-bar constructs commonly used for temporary external fixation of femoral shaft fractures. Their testing model simulated femoral shaft fractures in damage control situations. Fourth-generation synthetic femora (n=18) were used. The near-far construct had 2 pins that were 106 mm apart, placed 25 mm from the gap on each side of the fracture. The pin-bar construct pins were 55 mm apart, placed 40 mm from the gap. Mechanical testing was performed on a material test system machine. Stiffness was determined in the linear portion of the load-displacement curve for both constructs in 4 modes: axial compression, torsional loading, frontal plane 3-point bending, and sagittal plane 3-point bending. Costs were determined from a 2012 price guide. Compared with the near-far construct, the pin-bar construct had stiffness increased by 58% in axial compression (P<.05) and by 52% in torsional loading (P<.05). The pin-bar construct increased cost by 11%. In contrast to the authors' hypothesis and existing orthopedic dogma, the near-far construct was less stiff than the pin-bar construct and was similarly priced. Use of the pin-bar construct is mechanically and economically reasonable. [Orthopedics. 2017; 40(2):e238-e241.]. Copyright 2016, SLACK Incorporated.

  1. Wear-Induced Changes in FSW Tool Pin Profile: Effect of Process Parameters

    NASA Astrophysics Data System (ADS)

    Sahlot, Pankaj; Jha, Kaushal; Dey, G. K.; Arora, Amit

    2018-06-01

    Friction stir welding (FSW) of high melting point metallic (HMPM) materials has limited application due to tool wear and relatively short tool life. Tool wear changes the profile of the tool pin and adversely affects weld properties. A quantitative understanding of tool wear and tool pin profile is crucial to develop the process for joining of HMPM materials. Here we present a quantitative wear study of H13 steel tool pin profile for FSW of CuCrZr alloy. The tool pin profile is analyzed at multiple traverse distances for welding with various tool rotational and traverse speeds. The results indicate that measured wear depth is small near the pin root and significantly increases towards the tip. Near the pin tip, wear depth increases with increase in tool rotational speed. However, change in wear depth near the pin root is minimal. Wear depth also increases with decrease in tool traverse speeds. Tool pin wear from the bottom results in pin length reduction, which is greater for higher tool rotational speeds, and longer traverse distances. The pin profile changes due to wear and result in root defect for long traverse distance. This quantitative understanding of tool wear would be helpful to estimate tool wear, optimize process parameters, and tool pin shape during FSW of HMPM materials.

  2. Trending on Pinterest: an examination of pins about skin tanning.

    PubMed

    Banerjee, Smita C; Rodríguez, Vivian M; Greene, Kathryn; Hay, Jennifer L

    2018-04-10

    Rates of melanoma and nonmelanoma skin cancers are on the rise in the USA with data revealing disproportionate increase in female young adults. The popularity of intentional skin tanning among U.S. adolescents is attributed to several factors, including prioritization of physical appearance, media images of tanned celebrities, ease of availability of artificial tanning facilities, and more recently, the prevalence and celebration of tanned skin on social media. Pinterest, as the third most popular social media platform, was searched for "pins" about skin tanning. The resultant "pins" were examined to understand the extent and characteristics of skin tanning portrayed on Pinterest. We analyzed pins on Pinterest about skin tanning (n = 501) through a quantitative content analysis. Overall, results indicated an overwhelmingly protanning characteristic of pins about skin tanning on Pinterest, with over 85% of pins promoting tanning behavior. The pins were generally characterized by the portrayal of a female subject (61%) and provided positive reinforcement for tanning (49%). Use of tanning for enhancing appearance was the main positive outcome expectancy portrayed in the pins (35%), and nudity or exposure of skin on arms (32%) and legs (31%) was evident in about a third of pins. With overwhelmingly positive pins promoting tanning, use of female subjects, exhibiting nudity, and appearance enhancement, there seems be to a consistent targeting of female users to accept tanning as a socially acceptable and popular behavior. The findings indicate a need for developing sun protection messages and the leveraging of social media for dissemination of skin cancer prevention and detection messages.

  3. Effective augmentation of networked systems and enhancing pinning controllability

    NASA Astrophysics Data System (ADS)

    Jalili, Mahdi

    2018-06-01

    Controlling dynamics of networked systems to a reference state, known as pinning control, has many applications in science and engineering. In this paper, we introduce a method for effective augmentation of networked systems, while also providing high levels of pinning controllability for the final augmented network. The problem is how to connect a sub-network to an already existing network such that the pinning controllability is maximised. We consider the eigenratio of the augmented Laplacian matrix as a pinning controllability metric, and use graph perturbation theory to approximate the influence of edge addition on the eigenratio. The proposed metric can be effectively used to find the inter-network links connecting the disjoint networks. Also, an efficient link rewiring approach is proposed to further optimise the pinning controllability of the augmented network. We provide numerical simulations on synthetic networks and show that the proposed method is more effective than heuristic ones.

  4. 31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

  5. 31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

  6. 31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

  7. 31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

  8. 31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

  9. Pinning time statistics for vortex lines in disordered environments.

    PubMed

    Dobramysl, Ulrich; Pleimling, Michel; Täuber, Uwe C

    2014-12-01

    We study the pinning dynamics of magnetic flux (vortex) lines in a disordered type-II superconductor. Using numerical simulations of a directed elastic line model, we extract the pinning time distributions of vortex line segments. We compare different model implementations for the disorder in the surrounding medium: discrete, localized pinning potential wells that are either attractive and repulsive or purely attractive, and whose strengths are drawn from a Gaussian distribution; as well as continuous Gaussian random potential landscapes. We find that both schemes yield power-law distributions in the pinned phase as predicted by extreme-event statistics, yet they differ significantly in their effective scaling exponents and their short-time behavior.

  10. Corrosion of Ti6Al4V pins produced by direct metal laser sintering

    NASA Astrophysics Data System (ADS)

    de Damborenea, J. J.; Arenas, M. A.; Larosa, Maria Aparecida; Jardini, André Luiz; de Carvalho Zavaglia, Cecília Amélia; Conde, A.

    2017-01-01

    Direct Metal Laser Sintering (DMLS) technique allows the manufacturing a wide variety of medical devices for any type of prosthetic surgery (HIP, dental, cranial, maxillofacial) as well as for internal fixation devices (K-Wires or Steinmann Pins). There are a large number of research studies on DMLS, including microstructural characterization, mechanical properties and those based on production quality assurance but the influence of porosity in the corrosion behavior of these materials not been sufficiently considered. In the present paper, surgical pins of Ti6Al4V have been produced by DMLS. After testing in a phosphate buffered saline solution, the surface of the titanium alloy appeared locally covered by a voluminous white oxide. This unexpected behavior was presumably due to the existence of internal defects in the pins as result of the manufacturing process. The importance of these defects-that might act as crevice nucleation sites- has been revealed by electrochemical techniques and confirmed by computed tomography.

  11. 45 CFR 153.720 - Establishment and usage of masked enrollee identification numbers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Establishment and usage of masked enrollee identification numbers. 153.720 Section 153.720 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK...

  12. 45 CFR 153.720 - Establishment and usage of masked enrollee identification numbers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Establishment and usage of masked enrollee identification numbers. 153.720 Section 153.720 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS STANDARDS RELATED TO REINSURANCE, RISK CORRIDORS, AND RISK...

  13. Mechanics of advancing pin-loaded contacts with friction

    NASA Astrophysics Data System (ADS)

    Sundaram, Narayan; Farris, T. N.

    2010-11-01

    This paper considers finite friction contact problems involving an elastic pin and an infinite elastic plate with a circular hole. Using a suitable class of Green's functions, the singular integral equations governing a very general class of conforming contact problems are formulated. In particular, remote plate stresses, pin loads, moments and distributed loading of the pin by conservative body forces are considered. Numerical solutions are presented for different partial slip load cases. In monotonic loading, the dependence of the tractions on the coefficient of friction is strongest when the contact is highly conforming. For less conforming contacts, the tractions are insensitive to an increase in the value of the friction coefficient above a certain threshold. The contact size and peak pressure in monotonic loading are only weakly dependent on the pin load distribution, with center loads leading to slightly higher peak pressure and lower peak shear than distributed loads. In contrast to half-plane cylinder fretting contacts, fretting behavior is quite different depending on whether or not the pin is allowed to rotate freely. If pin rotation is disallowed, the fretting tractions resemble half-plane fretting tractions in the weakly conforming regime but the contact resists sliding in the strongly conforming regime. If pin rotation is allowed, the shear traction behavior resembles planar rolling contacts in that one slip zone is dominant and the peak shear occurs at its edge. In this case, the effects of material dissimilarity in the strongly conforming regime are only secondary and the contact never goes into sliding. Fretting tractions in the forward and reversed load states show shape asymmetry, which persists with continued load cycling. Finally, the governing integro-differential equation for full sliding is derived; in the limiting case of no friction, the same equation governs contacts with center loading and uniform body force loading, resulting in

  14. Stroboscopic phenomena in superconductors with dynamic pinning landscape

    PubMed Central

    Jelić, Ž. L.; Milošević, M. V.; Van de Vondel, J.; Silhanek, A. V.

    2015-01-01

    Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain without dissipation. In case of spatially periodic pinning, a clear enhancement of the superconducting critical current arises when commensurability between the vortex configurations and the pinning landscape occurs. With recent achievements in (ultrafast) optics and nanoengineered plasmonics it has become possible to exploit the interaction of light with superconductivity, and create not only spatially periodic imprints on the superconducting condensate, but also temporally periodic ones. Here we show that in the latter case, temporal matching phenomena develop, caused by stroboscopic commensurability between the characteristic frequency of the vortex motion under applied current and the frequency of the dynamic pinning. The matching resonances persist in a broad parameter space, including magnetic field, driving current, or material purity, giving rise to unusual features such as externally variable resistance/impedance and Shapiro steps in current-voltage characteristics. All features are tunable by the frequency of the dynamic pinning landscape. These findings open further exploration avenues for using flashing, spatially engineered, and/or mobile excitations on superconductors, permitting us to achieve advanced functionalities. PMID:26423610

  15. Evidence of new pinning centers in irradiated MgB2

    NASA Astrophysics Data System (ADS)

    Tarantini, C.; Martinelli, A.; Manfrinetti, P.; Palenzona, A.; Pallecchi, I.; Putti, M.; Ferdeghini, C.; Cimberle, M. R.

    2008-03-01

    It has been shown that C or SiC addictions can strongly enhance upper critical field of MgB2, leading to an in-field increase of critical current, but without introducing pinning centers other than grain boundaries. On the contrary neutron irradiation introduces new pinning centers, as highlighted by a significant shift of the maximum of pinning force and by a strong improvement of Jc at high field. This effect can be correlated to the defects that neutron irradiation produces. In fact TEM images show the presence of nanometric amorphous regions whose sizes are compatible with the coherence length and such as to act as pinning centers through two different mechanisms. The influence that neutron irradiation induces on MgB2 is also confirmed by magnetization decays that, differently by doped samples, show an important enhancement of pinning energies at high field. These measurements highlight as the increase of pinning energy with irradiation fluence is strongly correlated with Jc improvement.

  16. Reversible ratchet effects for vortices in conformal pinning arrays

    DOE PAGES

    Reichhardt, Charles; Ray, Dipanjan; Reichhardt, Cynthia Jane Olson

    2015-05-04

    A conformal transformation of a uniform triangular pinning array produces a structure called a conformal crystal which preserves the sixfold ordering of the original lattice but contains a gradient in the pinning density. Here we use numerical simulations to show that vortices in type-II superconductors driven with an ac drive over gradient pinning arrays produce the most pronounced ratchet effect over a wide range of parameters for a conformal array, while square gradient or random gradient arrays with equivalent pinning densities give reduced ratchet effects. In the conformal array, the larger spacing of the pinning sites in the direction transversemore » to the ac drive permits easy funneling of interstitial vortices for one driving direction, producing the enhanced ratchet effect. In the square array, the transverse spacing between pinning sites is uniform, giving no asymmetry in the funneling of the vortices as the driving direction switches, while in the random array, there are numerous easy-flow channels present for either direction of drive. We find multiple ratchet reversals in the conformal arrays as a function of vortex density and ac amplitude, and correlate the features with a reversal in the vortex ordering, which is greater for motion in the ratchet direction. In conclusion, the enhanced conformal pinning ratchet effect can also be realized for colloidal particles moving over a conformal array, indicating the general usefulness of conformal structures for controlling the motion of particles.« less

  17. Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.

    PubMed

    Xu, Tao; Zhang, Honglai; Park, Sung-Soo; Venneti, Sriram; Kuick, Rork; Ha, Kimberly; Michael, Lowell Evan; Santi, Mariarita; Uchida, Chiyoko; Uchida, Takafumi; Srinivasan, Ashok; Olson, James M; Dlugosz, Andrzej A; Camelo-Piragua, Sandra; Rual, Jean-François

    2017-03-01

    Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to quality of life. Alternative therapeutic approaches are needed. Genetic mutations leading to the activation of the Hedgehog pathway drive tumorigenesis in ~30% of medulloblastoma. In a yeast two-hybrid proteomic screen, we discovered a novel interaction between GLI1, a key transcription factor for the mediation of Hedgehog signals, and PIN1, a peptidylprolyl cis/trans isomerase that regulates the postphosphorylation fate of its targets. The GLI1/PIN1 interaction was validated by reciprocal pulldowns using epitope-tagged proteins in HEK293T cells as well as by co-immunoprecipiations of the endogenous proteins in a medulloblastoma cell line. Our results support a molecular model in which PIN1 promotes GLI1 protein abundance, thus contributing to the positive regulation of Hedgehog signals. Most importantly, in vivo functional analyses of Pin1 in the GFAP-tTA;TRE-SmoA1 mouse model of Hedgehog-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival. In summary, the discovery of the GLI1/PIN1 interaction uncovers PIN1 as a novel therapeutic target in Hedgehog-driven medulloblastoma tumorigenesis. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Bending of an Aspirated Pin During Rigid Bronchoscopy: Safeguards and Pitfalls.

    PubMed

    Elsayed, Abdelrahman A A; Mansour, Albaraa A; Amin, Ahmed A A; Ahmed, Mohsen S M

    2018-04-13

    Pin aspiration is a common problem in Muslim countries, where many women wear veils (hijab). This condition is usually treated using either a rigid or a flexible bronchoscope, and yet occasionally requires surgical approach. Pin bending may be necessary to extract impacted pins during the therapeutic rigid bronchoscopy. Medical records of patients who had pins extracted with a bending technique during the period from January 2012 to December 2016 in 1 institution were analyzed. Information on intraoperative and postoperative complications was collected. Between 2012 and 2016, 315 rigid bronchoscopies were performed for pin extraction; in 38 cases, bending of the pin was required for the extraction because they were in a position that did not allow simple extraction. The procedure was successful in cases and there were no major complications. The extraction of visible, distally located or impacted pins can be safely performed by experienced bronchoscopists using the bending technique. Some safeguards and pitfalls must be noted to ensure maximum safety.

  19. Flux pinning characteristics and irreversibility line in high temperature superconductors

    NASA Technical Reports Server (NTRS)

    Matsushita, T.; Ihara, N.; Kiuchi, M.

    1995-01-01

    The flux pinning properties in high temperature superconductors are strongly influenced by thermally activated flux motion. The scaling relation of the pinning force density and the irreversibility line in various high temperature superconductors are numerically analyzed in terms of the flux creep model. The effect of two factors, i.e., the flux pinning strength and the dimensionality of the material, on these properties are investigated. It is speculated that the irreversibility line in Bi-2212 superconductors is one order of magnitude smaller than that in Y-123, even if the flux pinning strength in Bi-2212 is improved up to the level of Y-123. It is concluded that these two factors are equally important in determination of the flux pinning characteristics at high temperatures.

  20. Retrievable fuel pin end member for a nuclear reactor

    DOEpatents

    Rosa, Jerry M.

    1982-01-01

    A bottom end member (17b) on a retrievable fuel pin (13b) secures the pin (13b) within a nuclear reactor (12) by engaging on a transverse attachment rail (18) with a spring clip type of action. Removal and reinstallation if facilitated as only axial movement of the fuel pin (13b) is required for either operation. A pair of resilient axially extending blades (31) are spaced apart to define a slot (24) having a seat region (34) which receives the rail (18) and having a land region (37), closer to the tips (39) of the blades (31) which is normally of less width than the rail (18). Thus an axially directed force sufficient to wedge the resilient blades (31) apart is required to emplace or release the fuel pin (13b) such force being greater than the axial forces on the fuel pins (13b) which occur during operation of the reactor (12).

  1. Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment

    PubMed Central

    Fan, Xiang-Kui; Yan, Rui-Hua; Geng, Xiang-Qun; Li, Jing-Shan; Chen, Xiang-Ming; Li, Jian-Zhe

    2016-01-01

    In the present study, to investigate the expression of PinX1 gene and its functional effects in human esophageal carcinoma (Eca)-109 cell line, expression vectors of human PinX1 (pEGFP-C3-PinX1) and its small interfering RNA (PinX1-FAM-siRNA) were constructed and transfected into Eca-109 cells using Lipofectamine 2000. Firstly, the mRNA expression level of PinX1 was examined using reverse transcription-polymerase chain reaction (RT-PCR). Once successful transfection was achieved, the effects on the mRNA level of human telomerase reverse transcriptase (hTERT), telomerase activity, cell proliferation and apoptosis were examined by semi-quantitative RT-PCR, stretch PCR, MTT assay and flow cytometry, respectively. Analysis of restriction and sequencing demonstrated that the recombining plasmids were successfully constructed. The results also indicated that transfection with pEGFP-C3-PinX1 and PinX1-FAM-siRNA into Eca-109 cells significantly increased PinX1 mRNA, decreased hTERT mRNA by 29.9% (P<0.05), and significantly reduced telomerase activity (P<0.05), inhibited cell growth, and increased the cell apoptotic index from 19.27±0.76 to 49.73±2%. The transfected PinX1-FAM-SiRNA exhibited PinX1 mRNA expression levels that were significantly decreased by 70% (P<0.05), whereas the remaining characteristics of Eca-109 cells, including cell growth, mRNA level of hTERT, telomerase activity and cell apoptotic index were not altered. Exogenous PinX1 has been demonstrated to be highly expressed in human Eca. PinX1 can inhibit human telomerase activity and the expression of hTERT mRNA, reduce tumor cell growth and induce apoptosis. Notably, these inhibitory functions were inhibited by silencing PinX1 in Eca with PinX1-FAM-siRNA. PinX1 was successfully increased and decreased in the present study, demonstrating that it may be a potential telomerase activity inhibitor. As PinX1 is an endogenous telomerase inhibitor, it may be used as a novel tumor-targeted gene therapy. PMID

  2. Theory of activated glassy dynamics in randomly pinned fluids.

    PubMed

    Phan, Anh D; Schweizer, Kenneth S

    2018-02-07

    We generalize the force-level, microscopic, Nonlinear Langevin Equation (NLE) theory and its elastically collective generalization [elastically collective nonlinear Langevin equation (ECNLE) theory] of activated dynamics in bulk spherical particle liquids to address the influence of random particle pinning on structural relaxation. The simplest neutral confinement model is analyzed for hard spheres where there is no change of the equilibrium pair structure upon particle pinning. As the pinned fraction grows, cage scale dynamical constraints are intensified in a manner that increases with density. This results in the mobile particles becoming more transiently localized, with increases of the jump distance, cage scale barrier, and NLE theory mean hopping time; subtle changes of the dynamic shear modulus are predicted. The results are contrasted with recent simulations. Similarities in relaxation behavior are identified in the dynamic precursor regime, including a roughly exponential, or weakly supra-exponential, growth of the alpha time with pinning fraction and a reduction of dynamic fragility. However, the increase of the alpha time with pinning predicted by the local NLE theory is too small and severely so at very high volume fractions. The strong deviations are argued to be due to the longer range collective elasticity aspect of the problem which is expected to be modified by random pinning in a complex manner. A qualitative physical scenario is offered for how the three distinct aspects that quantify the elastic barrier may change with pinning. ECNLE theory calculations of the alpha time are then presented based on the simplest effective-medium-like treatment for how random pinning modifies the elastic barrier. The results appear to be consistent with most, but not all, trends seen in recent simulations. Key open problems are discussed with regard to both theory and simulation.

  3. Theory of activated glassy dynamics in randomly pinned fluids

    NASA Astrophysics Data System (ADS)

    Phan, Anh D.; Schweizer, Kenneth S.

    2018-02-01

    We generalize the force-level, microscopic, Nonlinear Langevin Equation (NLE) theory and its elastically collective generalization [elastically collective nonlinear Langevin equation (ECNLE) theory] of activated dynamics in bulk spherical particle liquids to address the influence of random particle pinning on structural relaxation. The simplest neutral confinement model is analyzed for hard spheres where there is no change of the equilibrium pair structure upon particle pinning. As the pinned fraction grows, cage scale dynamical constraints are intensified in a manner that increases with density. This results in the mobile particles becoming more transiently localized, with increases of the jump distance, cage scale barrier, and NLE theory mean hopping time; subtle changes of the dynamic shear modulus are predicted. The results are contrasted with recent simulations. Similarities in relaxation behavior are identified in the dynamic precursor regime, including a roughly exponential, or weakly supra-exponential, growth of the alpha time with pinning fraction and a reduction of dynamic fragility. However, the increase of the alpha time with pinning predicted by the local NLE theory is too small and severely so at very high volume fractions. The strong deviations are argued to be due to the longer range collective elasticity aspect of the problem which is expected to be modified by random pinning in a complex manner. A qualitative physical scenario is offered for how the three distinct aspects that quantify the elastic barrier may change with pinning. ECNLE theory calculations of the alpha time are then presented based on the simplest effective-medium-like treatment for how random pinning modifies the elastic barrier. The results appear to be consistent with most, but not all, trends seen in recent simulations. Key open problems are discussed with regard to both theory and simulation.

  4. COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer.

    PubMed

    Kim, Garam; Khanal, Prem; Kim, Jin Young; Yun, Hyo-Jeong; Lim, Sung-Chul; Shim, Jung-Hyun; Choi, Hong Seok

    2015-06-01

    Pin1, a conserved eukaryotic Peptidyl-prolyl cis/trans isomerase, has profound effects on numerous key-signaling molecules, and its deregulation contributes to disease, particularly cancer. Although Pin1-mediated prolyl isomerization is an essential and novel regulatory mechanism for protein phosphorylation, little is known about the upstream signaling pathway(s) that regulates Pin1 activity. Here, we identify MAP3K-related serine-threonine kinase (the gene encoding COT/Tpl2) as a kinase responsible for phosphorylation of Pin1 Ser16. COT interacts with and phosphorylates Pin1 on Ser16. Consequently, Pin1 Ser16 phosphorylation by COT increases cyclin D1 abundance and enhances tumorigenecity of MCF7 cells. In contrast, depletion of COT in MCF7 cells leads to downregulation of Pin1 Ser16 phosphorylation, which subsequently decrease cyclin D1 levels, inhibiting tumorigenecity of MCF7 cells. In a xenograft model, treatment of TKI, a COT inhibitor, and Juglone, a Pin1 inhibitor, abrogates tumor growth. In human breast cancer patients, immunohistochemical staining shows that Pin1 pSer16 levels are positively correlated with COT levels, providing strong evidence for an essential role of the COT/Pin1 axis in conveying oncogenic signals to promote aggressiveness in human breast cancer. © 2013 Wiley Periodicals, Inc.

  5. Magnetization pinning in conducting films demonstrated using broadband ferromagnetic resonance

    NASA Astrophysics Data System (ADS)

    Kostylev, M.; Stashkevich, A. A.; Adeyeye, A. O.; Shakespeare, C.; Kostylev, N.; Ross, N.; Kennewell, K.; Magaraggia, R.; Roussigné, Y.; Stamps, R. L.

    2010-11-01

    The broadband microstrip ferromagnetic resonance (FMR), cavity FMR, and Brillouin light scattering spectroscopy techniques have been applied for detection and characterization of a magnetic inhomogeneity in a film sample. In the case of a 100 nm thick permalloy film, an additional magnetically depleted top sublayer has been detected due to pinning effect it produces on the magnetization in the bulk of the film. The pinning results in appearance of an exchange standing spin wave mode in the broadband FMR absorption spectrum, whose amplitudes are different depending on whether the film or the film substrate faces the microstrip transducer. Comparison of the experimental amplitudes for this mode with results of our theory for both film placements revealed that the depleted layer is located at the film surface facing away from the film substrate. Subsequent broadband FMR characterization of a large number of other presumably single-layer films with thicknesses in the range 30-100 nm showed the same result.

  6. Effect of the starting point of half-pin insertion on the insertional torque of the pin at the tibia.

    PubMed

    Kim, Sung Jae; Kim, Sung Hwan; Kim, Young Hwan; Chun, Yong Min

    2015-01-01

    The authors have observed a failure to achieve secure fixation in elderly patients when inserting a half-pin at the anteromedial surface of the tibia. The purpose of this study was to compare two methods for inserting a half-pin at tibia diaphysis in elderly patients. Twenty cadaveric tibias were divided into Group C or V. A half-pin was inserted into the tibias of Group C via the conventional method, from the anteromedial surface to the interosseous border of the tibia diaphysis, and into the tibias of Group V via the vertical method, from the anterior border to the posterior surface at the same level. The maximum insertion torque was measured during the bicortical insertion with a torque driver. The thickness of the cortex was measured by micro-computed tomography. The relationship between the thickness of the cortex engaged and the insertion torque was investigated. The maximum insertion torque and the thickness of the cortex were significantly higher in Group V than Group C. Both groups exhibited a statistically significant linear correlation between torque and thickness by Spearman's rank correlation analysis. Half-pins inserted by the vertical method achieved purchase of more cortex than those inserted by the conventional method. Considering that cortical thickness and insertion torque in Group V were significantly greater than those in Group C, we suggest that the vertical method of half-pin insertion may be an alternative to the conventional method in elderly patients.

  7. Decursin exerts anti-cancer activity in MDA-MB-231 breast cancer cells via inhibition of the Pin1 activity and enhancement of the Pin1/p53 association.

    PubMed

    Kim, Ji-Hyun; Jung, Ji Hoon; Kim, Sung-Hoon; Jeong, Soo-Jin

    2014-02-01

    The peptidyl-prolyl cis/trans isomerase Pin1 is overexpressed in a wide variety of cancer cells and thus considered as an important target molecule for cancer therapy. This study demonstrates that decursin, a bioactive compound from Angelica gigas, exert the anti-cancer effect against breast cancer cells via regulation of Pin1 and its related signaling molecules. We observed that decursin induced G1 arrest with decrease in cyclin D1 level in Pin1-expressing breast cancer cells MDA-MB-231, but not Pin1-non-expressing breast cancer cells MDA-MB-157. In addition, decursin significantly reduced protein expression and enzymatic activity of Pin1 in MDA-MB-231 cells. Further, we found that decursin treatment enhanced the p53 expression level and failed to down-regulate Pin1 in the cells transfected with p53 siRNA, indicating the importance of p53 in the decursin-mediated Pin1 inhibition in MDA-MB-231 cells. Decursin stimulated association between Pin1 to p53. Moreover, decursin facilitated p53 transcription in MDA-MB-231 cells. Overall, our current study suggests the potential of decursin as an attractive cancer therapeutic agent for breast cancer by targeting Pin1 protein. Copyright © 2013 John Wiley & Sons, Ltd.

  8. Pin1-FADD interactions regulate Fas-mediated apoptosis in activated eosinophils#

    PubMed Central

    Oh, Jiyoung; Malter, James S.

    2013-01-01

    Abnormally long-lived eosinophils (Eos) are the major inflammatory component of allergic responses in the lungs of active asthmatics. Eos recruited to the airways after allergen exposure produce and respond to IL-5 and GM-CSF, enhancing their survival. Pro-survival signaling activates Pin1, a cis-trans peptidyl isomerase (PPIase) that binds to Bax and prevents it activation. How long-lived Eos, despite the continued presence of GM-CSF or IL-5, eventually undergo apoptosis to end allergic inflammation remains unclear. Here we show that Pin1 location, activity and protein interactions are jointly influenced by Fas and pro-survival cytokine IL-5. Fas signaling strongly induced the phosphorylation of FADD at Ser194 and Pin1 at Ser16 as well as their nuclear accumulation. Phospho-mimic Ser194Glu FADD mutants accelerated Eos apoptosis compared to WT or Ser194Ala mutants. Downstream of FADD phosphorylation, Caspase 8, 9 and 3 cleavage as well as Eos apoptosis induced by Fas were reduced by constitutively active Pin1 and enhanced by Pin1 inhibition. Pin1 was activated by IL-5 while simultaneous IL-5 and anti-Fas treatment modestly reduced PPIase activity but induced Pin1 to associate with FADD after its phosphorylation at Ser194. Mechanistically, Pin1 mediated isomerization facilitated the subsequent dephosphorylation of Ser194 FADD and maintenance of cytoplasmic location. In vivo activated bronchoalvelolar (BAL) Eos obtained after allergen challenge showed elevated survival and Pin1 activity that could be reversed by anti-Fas. Therefore, our data suggest that Pin1 is a critical link between FADD mediated cell death and IL-5 mediated pro-survival signaling. PMID:23606538

  9. The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.

    PubMed

    Nakatsu, Yusuke; Mori, Keiichi; Matsunaga, Yasuka; Yamamotoya, Takeshi; Ueda, Koji; Inoue, Yuki; Mitsuzaki-Miyoshi, Keiko; Sakoda, Hideyuki; Fujishiro, Midori; Yamaguchi, Suguru; Kushiyama, Akifumi; Ono, Hiraku; Ishihara, Hisamitsu; Asano, Tomoichiro

    2017-07-14

    The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to show that Pin1 expression in pancreatic β cells is markedly elevated by high-fat diet feeding and in ob/ob mice. To elucidate the role of Pin1 in pancreatic β cells, we generated β-cell-specific Pin1 KO (βPin1 KO) mice. These mutant mice showed exacerbation of glucose intolerance but had normal insulin sensitivity. We identified two independent factors underlying impaired insulin secretion in the βPin1 KO mice. Pin1 enhanced pancreatic β-cell proliferation, as indicated by a reduced β-cell mass in βPin1 KO mice compared with control mice. Moreover, a diet high in fat and sucrose failed to increase pancreatic β-cell growth in the βPin1 KO mice, an observation to which up-regulation of the cell cycle protein cyclin D appeared to contribute. The other role of Pin1 was to activate the insulin-secretory step: Pin1 KO β cells showed impairments in glucose- and KCl-induced elevation of the intracellular Ca 2+ concentration and insulin secretion. We also identified salt-inducible kinase 2 (SIK2) as a Pin1-binding protein that affected the regulation of Ca 2+ influx and found Pin1 to enhance SIK2 kinase activity, resulting in a decrease in p35 protein, a negative regulator of Ca 2+ influx. Taken together, our observations demonstrate critical roles of Pin1 in pancreatic β cells and that Pin1 both promotes β-cell proliferation and activates insulin secretion. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. 18. SHEAR PIN, UNIT 24 GORGE POWERHOUSE. THE WICKET GATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. SHEAR PIN, UNIT 24 GORGE POWERHOUSE. THE WICKET GATES ON THE TURBINE ARE EACH EQUIPPED WITH A SHEAR PIN AND OIL PRESSURE GAUGE. IF A GATE JAMS, THE PIN SMEARS AND THE CHANGE IN OIL PRESSURE TRIGGERS AN ALARM, 1989. - Skagit Power Development, Gorge Powerhouse, On Skagit River, 0.4 mile upstream from Newhalem, Newhalem, Whatcom County, WA

  11. 77 FR 51782 - Federal Acquisition Regulation; Information Collection; Taxpayer Identification Number Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... agency is required to furnish its Tax Identification Number (TIN) to that agency. 31 U.S.C. 3325(d... and submitted to a disbursing official, the TIN of the contractor receiving payment under the voucher... other information, its TIN. The TIN may be used by the Government to collect and report on any...

  12. Exchange anisotropy pinning of a standing spin-wave mode

    NASA Astrophysics Data System (ADS)

    Magaraggia, R.; Kennewell, K.; Kostylev, M.; Stamps, R. L.; Ali, M.; Greig, D.; Hickey, B. J.; Marrows, C. H.

    2011-02-01

    Standing spin waves in a thin film are used as sensitive probes of interface pinning induced by an antiferromagnet through exchange anisotropy. Using coplanar waveguide ferromagnetic resonance, pinning of the lowest energy spin-wave thickness mode in Ni80Fe20/Ir25Mn75 exchange-biased bilayers was studied for a range of Ir25Mn75 thicknesses. We show that pinning of the standing mode can be used to amplify, relative to the fundamental resonance, frequency shifts associated with exchange bias. The shifts provide a unique “fingerprint” of the exchange bias and can be interpreted in terms of an effective ferromagnetic film thickness and ferromagnet-antiferromagnet interface anisotropy. Thermal effects are studied for ultrathin antiferromagnetic Ir25Mn75 thicknesses, and the onset of bias is correlated with changes in the pinning fields. The pinning strength magnitude is found to grow with cooling of the sample, while the effective ferromagnetic film thickness simultaneously decreases. These results suggest that exchange bias involves some deformation of magnetic order in the interface region.

  13. IMp: The customizable LEGO® Pinned Insect Manipulator

    PubMed Central

    Dupont, Steen; Price, Benjamin; Blagoderov, Vladimir

    2015-01-01

    Abstract We present a pinned insect manipulator (IMp) constructed of LEGO® building bricks with two axes of movement and two axes of rotation. In addition we present three variants of the IMp to emphasise the modular design, which facilitates resizing to meet the full range of pinned insect specimens, is fully customizable, collapsible, affordable and does not require specialist tools or knowledge to assemble. PMID:25685035

  14. Effect of Pin Tool Shape on Metal Flow During Friction Stir Welding

    NASA Technical Reports Server (NTRS)

    McClure, J. C.; Coronado, E.; Aloor, S.; Nowak, B.; Murr, L. M.; Nunes, Arthur C., Jr.; Munafo, Paul M. (Technical Monitor)

    2002-01-01

    It has been shown that metal moves behind the rotating Friction Stir Pin Tool in two separate currents or streams. One current, mostly on the advancing side, enters a zone of material that rotates with the pin tool for one or more revolutions and eventually is abandoned behind the pin tool in crescent-shaped pieces. The other current, largely on the retreating side of the pin tool is moved by a wiping process to the back of the pin tool and fills in between the pieces of the rotational zone that have been shed by the rotational zone. This process was studied by using a faying surface copper trace to clarify the metal flow. Welds were made with pin tools having various thread pitches. Decreasing the thread pitch causes the large scale top-to-bottorn flow to break up into multiple vortices along the pin and an unthreaded pin tool provides insufficient vertical motion for there to be a stable rotational zone and flow of material via the rotational zone is not possible leading to porosity on the advancing side of the weld.

  15. Displaced humeral lateral condyle fractures in children: should we bury the pins?

    PubMed

    Das De, Soumen; Bae, Donald S; Waters, Peter M

    2012-09-01

    The purpose of this investigation was to determine if leaving Kirschner wires exposed is more cost-effective than burying them subcutaneously after open reduction and internal fixation (ORIF) of humeral lateral condyle fractures. A retrospective cohort study of all lateral condyle fractures treated over a 10-year period at a single institution was performed. Data on surgical technique, fracture healing, and complications were analyzed, as well as treatment costs. A decision analysis model was then constructed to compare the strategies of leaving the pins exposed versus buried. Finally, sensitivity analyses were performed, assessing cost-effectiveness when infection rates and costs of treating deep infections were varied. A total of 235 children with displaced fractures were treated with ORIF using Kirschner wires. Pins were left exposed in 41 cases (17.4%) and buried in 194 cases (82.6%); the age, sex, injury mechanisms, and fracture patterns were similar in both the groups. The median time to removal of implants was shorter with exposed versus buried pins (4 vs. 6 wk, P<0.001), although there was no difference in fracture union or loss of reduction rates. The rate of superficial infection was higher with exposed pins (9.8% vs. 3.1%), but this was not statistically significant (P=0.076). There were no deep infections with exposed pins, whereas the rate of deep infection was 0.5% with buried pins (P=1.00). Buried pins were associated with additional complications, including symptomatic implants (7.2%); pins protruding through the skin (16%); internal pin migration necessitating additional surgery (1%); and skin necrosis (1%). The decision analysis revealed that leaving pins exposed resulted in an average cost savings of $3442 per patient. This strategy remained cost-effective even when infection rates with exposed pins approached 40%. Leaving the pins exposed after ORIF of lateral condyle fractures is safe and more cost-effective than burying the pins subcutaneously

  16. Dosimetric characteristics of a PIN diode for radiotherapy application.

    PubMed

    Kumar, R; Sharma, S D; Philomina, A; Topkar, A

    2014-08-01

    The PIN diode developed by Bhabha Atomic Research Centre (BARC) was modified for its use as a dosimeter in radiation therapy. For this purpose the diode was mounted on a printed circuit board (PCB) and provided with necessary connections so that its response against irradiation can be recorded by a standard radiotherapy electrometer. The dosimetric characteristics of the diode were studied in Co-60 gamma rays as well as high energy X-rays. The measured sensitivity of this PIN diode is 4 nC/cGy which is about ten times higher than some commercial diode dosimeters. The leakage current from the diode is 0.04 nA. The response of the PIN diode is linear in the range of 20-1000 cGy which covers the full range of radiation dose encountered in radiotherapy treatments. The non-linearity of the diode response is 3.5% at 20 cGy and it is less than 1.5% at higher dose values. Its repeatability is within 0.5%. The angular response variation is about 5.6% within 6608 with respect to normal beam incidence. The response of the PIN diode at 6 and 18 MV X-rays varies within 2% with respect to its response at Co-60 gamma rays. The source to surface distance (SSD) dependence of the PIN diode was studied for Co-60 beam. It was found that the response of the diode decreases almost linearly relative to given dose for beams with constant collimator setting but increasing SSD (decreasing dose-rate). Within this study the diode response varied by about 2.5% between the maximum and minimum SSD. The dose-rate dependence of the PIN diode for 6 and 15 MV-rays was studied. The variation in response of diode for both energies in the studied dose range is less than 1%. The field size dependence of the PIN diode response is within 1% with respect to the response of ionisation chamber. These studies indicate that the characteristics of the PIN diode are suitable for use in radiotherapy dosimetry.

  17. Genome-Wide Identification and Expression Profiling Analysis of ZmPIN, ZmPILS, ZmLAX and ZmABCB Auxin Transporter Gene Families in Maize (Zea mays L.) under Various Abiotic Stresses

    PubMed Central

    Sun, Tao; Zhang, Lei; Yang, Yanjun; Qi, Jianshuang; Yan, Shufeng; Han, Xiaohua; Wang, Huizhong; Shen, Chenjia

    2015-01-01

    The auxin influx carriers auxin resistant 1/like aux 1 (AUX/LAX), efflux carriers pin-formed (PIN) (together with PIN-like proteins) and efflux/conditional P-glycoprotein (ABCB) are major protein families involved in auxin polar transport. However, how they function in responses to exogenous auxin and abiotic stresses in maize is largely unknown. In this work, the latest updated maize (Zea mays L.) reference genome sequence was used to characterize and analyze the ZmLAX, ZmPIN, ZmPILS and ZmABCB family genes from maize. The results showed that five ZmLAXs, fifteen ZmPINs, nine ZmPILSs and thirty-five ZmABCBs were mapped on all ten maize chromosomes. Highly diversified gene structures, nonconservative transmembrane helices and tissue-specific expression patterns suggested the possibility of function diversification for these genes. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the expression patterns of ZmLAX, ZmPIN, ZmPILS and ZmABCB genes under exogenous auxin and different environmental stresses. The expression levels of most ZmPIN, ZmPILS, ZmLAX and ZmABCB genes were induced in shoots and were reduced in roots by various abiotic stresses (drought, salt and cold stresses). The opposite expression response patterns indicated the dynamic auxin transport between shoots and roots under abiotic stresses. Analysis of the expression patterns of ZmPIN, ZmPILS, ZmLAX and ZmABCB genes under drought, salt and cold treatment may help us to understand the possible roles of maize auxin transporter genes in responses and tolerance to environmental stresses. PMID:25742625

  18. Proper PIN1 Distribution Is Needed for Root Negative Phototropism in Arabidopsis

    PubMed Central

    Zhang, Kun-Xiao; Xu, Heng-Hao; Gong, Wen; Jin, Yan; Shi, Ya-Ya; Yuan, Ting-Ting; Li, Juan; Lu, Ying-Tang

    2014-01-01

    Plants can be adapted to the changing environments through tropic responses, such as light and gravity. One of them is root negative phototropism, which is needed for root growth and nutrient absorption. Here, we show that the auxin efflux carrier PIN-FORMED (PIN) 1 is involved in asymmetric auxin distribution and root negative phototropism. In darkness, PIN1 is internalized and localized to intracellular compartments; upon blue light illumination, PIN1 relocalize to basal plasma membrane in root stele cells. The shift of PIN1 localization induced by blue light is involved in asymmetric auxin distribution and root negative phototropic response. Both blue-light-induced PIN1 redistribution and root negative phototropism is mediated by a BFA-sensitive trafficking pathway and the activity of PID/PP2A. Our results demonstrate that blue-light-induced PIN1 redistribution participate in asymmetric auxin distribution and root negative phototropism. PMID:24465665

  19. Proper PIN1 distribution is needed for root negative phototropism in Arabidopsis.

    PubMed

    Zhang, Kun-Xiao; Xu, Heng-Hao; Gong, Wen; Jin, Yan; Shi, Ya-Ya; Yuan, Ting-Ting; Li, Juan; Lu, Ying-Tang

    2014-01-01

    Plants can be adapted to the changing environments through tropic responses, such as light and gravity. One of them is root negative phototropism, which is needed for root growth and nutrient absorption. Here, we show that the auxin efflux carrier PIN-FORMED (PIN) 1 is involved in asymmetric auxin distribution and root negative phototropism. In darkness, PIN1 is internalized and localized to intracellular compartments; upon blue light illumination, PIN1 relocalize to basal plasma membrane in root stele cells. The shift of PIN1 localization induced by blue light is involved in asymmetric auxin distribution and root negative phototropic response. Both blue-light-induced PIN1 redistribution and root negative phototropism is mediated by a BFA-sensitive trafficking pathway and the activity of PID/PP2A. Our results demonstrate that blue-light-induced PIN1 redistribution participate in asymmetric auxin distribution and root negative phototropism.

  20. Pneumocranium secondary to halo vest pin penetration through an enlarged frontal sinus.

    PubMed

    Cheong, Min Lee; Chan, Chris Yin Wei; Saw, Lim Beng; Kwan, Mun Keong

    2009-07-01

    We present a case report of a patient with pneumocranium secondary to halo vest pin penetration and a review of literature. The objectives of this study are to report a rare complication of halo vest pin insertion and to discuss methods of prevention of this complication. Halo vest orthosis is a commonly used and well-tolerated upper cervical spinal stabilizing device. Reports of complications related to pin penetration is rare and from our review, there has been no reports of pneumocranium occurring from insertion of pins following standard anatomical landmarks. A 57-year-old male sustained a type 1 traumatic spondylolisthesis of C2/C3 following a motor vehicle accident. During application of the halo vest, penetration of the left anterior pin through the abnormally enlarged frontal sinus occurred. The patient developed headache, vomiting and CSF rhinorrhoea over his left nostril. He was treated with intravenous Ceftriaxone for 1 week. This resulted in resolution of his symptoms as well as the pneumocranium. In conclusion, complications of halo vest pin penetration are rare and need immediate recognition. Despite the use of anatomical landmarks, pin penetration is still possible due to aberrant anatomy. All patients should have a skull X-ray with a radio-opaque marker done prior to placement of the halo vest pins and halo vest pins have to be inserted by experienced personnel to enable early detection of pin penetration.

  1. Stability of Pin1 as revealed by thermal and spectroscopic studies

    NASA Astrophysics Data System (ADS)

    Wang, Jing-Zhang; Lin, Tao; Zhu, Guo-Fei; Du, Lin-Fang

    2010-06-01

    Pin1 is a two-domain enzyme which has peptidyl-prolyl cis/trans isomerase activity. Pin1 recognizes phospho-Ser/Thr-Pro motifs in cell-signaling proteins, and is both a cancer and an Alzheimer's disease target. The thermal stability of Pin1 was studied intensively by SDS-PAGE, enzymatic activity assay, intrinsic fluorescence spectroscopy and circular dichroism spectroscopy. The activity of Pin1 gradually decreased above 40 °C, and the Tm was 57.6 ± 1.0 °C. Fluorescence experiments indicated that heat treatment induced changes in the substructures in Pin1, resulting in that the polarity in the microenvironments of the tryptophan residues increased. It is assumed that the thermal denaturation of Pin1 involved a three-state transition. The intermediate state of Pin1 at about 60 °C was confirmed by fluorescence emission spectra, the synchronous fluorescence spectra and CD measurements. Decreases in α-helix and β-sheet appeared above 40 °C, which was balanced by an enhancement in unordered coil. The Tm values calculated from α-helix transition and β-sheet transition were 54.6 ± 0.6 °C and 70.7 ± 3.3 °C, respectively. Our results illustrated that Pin1 had a relatively high thermal stability and the WW domain had a higher stability than the PPIase domain.

  2. Pin cherry effects on Allegheny hardwood stand development

    Treesearch

    Todd E. Ristau; Stephen B. Horsley

    1999-01-01

    Pin cherry (Prunus pensylvanica L.) develops an early height advantage over associated species. Data from three long-term studies, extending up to 70 years after complete overstory removal, were used to evaluate the effects of pin cherry density on associates. Survival of seedling-origin stems of black cherry (Prunus serotina Ehrh...

  3. Plasma membrane-targeted PIN proteins drive shoot development in a moss.

    PubMed

    Bennett, Tom A; Liu, Maureen M; Aoyama, Tsuyoshi; Bierfreund, Nicole M; Braun, Marion; Coudert, Yoan; Dennis, Ross J; O'Connor, Devin; Wang, Xiao Y; White, Chris D; Decker, Eva L; Reski, Ralf; Harrison, C Jill

    2014-12-01

    Plant body plans arise by the activity of meristematic growing tips during development and radiated independently in the gametophyte (n) and sporophyte (2n) stages of the life cycle during evolution. Although auxin and its intercellular transport by PIN family efflux carriers are primary regulators of sporophytic shoot development in flowering plants, the extent of conservation in PIN function within the land plants and the mechanisms regulating bryophyte gametophytic shoot development are largely unknown. We have found that treating gametophytic shoots of the moss Physcomitrella patens with exogenous auxins and auxin transport inhibitors disrupts apical function and leaf development. Two plasma membrane-targeted PIN proteins are expressed in leafy shoots, and pin mutants resemble plants treated with auxins or auxin transport inhibitors. PIN-mediated auxin transport regulates apical cell function, leaf initiation, leaf shape, and shoot tropisms in moss gametophytes. pin mutant sporophytes are sometimes branched, reproducing a phenotype only previously seen in the fossil record and in rare natural moss variants. Our results show that PIN-mediated auxin transport is an ancient, conserved regulator of shoot development. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  4. Closed-Loop Control System for Friction Stir Welding Retractable Pin Tool

    NASA Technical Reports Server (NTRS)

    Ding, R. Jeffrey; Romine, Peter L.; Munafo, Paul M. (Technical Monitor)

    2001-01-01

    NASA invention disclosure, NASA Case No. MFS-31413, entitled "System for Controlling the Stirring Pin of a Friction Stir Welding Apparatus", (Patent Pending) authored by Jeff Ding, Dr Peter Romine and Pete Oelgoetz, addresses the precision control of the friction stir welding process. The closed-loop control system automatically adjusts the spinning welding pin, real-time, to maintain a precise penetration ligament (i.e., distance between pin-tip and weld panel backside surface). A specific pin length can be maintained while welding constant thickness or tapered material thickness weld panels. The closed-loop control system provides operator data and information relative to the exact position of the welding pin inside the weld joint. This paper presents the closed-loop RPT control system that operates using the auto-feedback of force signals sensed by the tip and shoulder of the welding pin. Significance: The FSW process can be successfully used in a production environment only if there is a method or technique that informs the FSW operator the precise location of the welding pin inside the weld joint. This is essential for applications in aerospace, automotive, pressure vessel, commercial aircraft and other industries.

  5. Biomechanical influence of pin placement and elbow angle on joint distraction and hinge alignment for an arthrodiatasis elbow-pin-fixator construct.

    PubMed

    Lee, Wei-Shiun; Linz, Shang-Chih; Shih, Kao-Shang; Chao, Ching-Kong; Chen, Yeung-Jen; Fan, Chang-Yuan

    2012-10-01

    Stiffness and contracture of the periarticular tissues are common complications of a post-traumatic elbow. Arthrodiatasis is a surgical technique that uses an external fixator for initial immobilization and subsequent distraction. The two prerequisites for an ideal arthrodiatasis are concentric distraction (avoiding bony contact) and hinge alignment (reducing internal stress). This study used the finite element (FE) method to clarify the relationship between these two prerequisites and the initial conditions (pin placement, elbow angle, and distraction mode). A total of 12 variations of the initial conditions were symmetrically arranged to evaluate their biomechanical influence on concentric distraction and hinge alignment. The humeroulnar surface was hypothesized to be ideally distracted orthogonal to the line joining the tips of the olecranon and the coronoid. The eccentric separation of the humeroulnar surfaces is a response to the non-orthogonality of the distracting force and joining line. Pin placement significantly affects the effective moment arm of the fixing pins to distract the bridged elbow. Both elbow angle and distraction mode directly alter the direction of the distracting force at the elbow center. In general, the hinges misalignment occurs in a direction opposite to the distraction-activated site. After joint distraction, the elastic deflection of the fixing pins inevitably makes both elbow and fixator hinges to misalign. This indicates that both joint distraction and hinge alignment are the interactive mechanisms. The humeroulnar separation is more concentric in the situation of the 120 degrees humeral distraction by using stiffer pins with convergent placement. Even so, the eccentric displacement of the elbow hinge is a crucial consideration in the initial placement of the guiding pin to compensate for hinge misalignment.

  6. Percutaneous external fixator pins with bactericidal micron-thin sol-gel films for the prevention of pin tract infection.

    PubMed

    Qu, Haibo; Knabe, Christine; Radin, Shula; Garino, Jonathan; Ducheyne, Paul

    2015-09-01

    Risk of infection is considerable in open fractures, especially when fracture fixation devices are used to stabilize the fractured bones. Overall deep infection rates of 16.2% have been reported. The infection rate is even greater, up to 32.2%, with external fixation of femoral fractures. The use of percutaneous implants for certain clinical applications, such as percutaneous implants for external fracture fixation, still represents a challenge today. Currently, bone infections are very difficult to treat. Very potent antibiotics are needed, which creates the risk of irreversible damage to other organs, when the antibiotics are administered systemically. As such, controlled, local release is being pursued, but no such treatments are in clinical use. Herein, the use of bactericidal micron-thin sol-gel films on metallic fracture fixation pins is reported. The data demonstrates that triclosan (2,4,4'-trichloro-2'-hydroxydiphenylether), an antimicrobial agent, can be successfully incorporated into micron-thin sol-gel films deposited on percutaneous pins. The sol-gel films continuously release triclosan in vitro for durations exceeding 8 weeks (longest measured time point). The bactericidal effect of the micron-thin sol-gel films follows from both in vitro and in vivo studies. Inserting percutaneous pins in distal rabbit tibiae, there were no signs of infection around implants coated with a micron-thin sol-gel/triclosan film. Healing had progressed normally, bone tissue growth was normal and there was no epithelial downgrowth. This result was in contrast with the results in rabbits that received control, uncoated percutaneous pins, in which abundant signs of infection and epithelial downgrowth were observed. Thus, well-adherent, micron-thin sol-gel films laden with a bactericidal molecule successfully prevented pin tract infection. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Evaluating Approaches to Rendering Braille Text on a High-Density Pin Display.

    PubMed

    Morash, Valerie S; Russomanno, Alexander; Gillespie, R Brent; OModhrain, Sile

    2017-10-13

    Refreshable displays for tactile graphics are typically composed of pins that have smaller diameters and spacing than standard braille dots. We investigated configurations of high-density pins to form braille text on such displays using non-refreshable stimuli produced with a 3D printer. Normal dot braille (diameter 1.5 mm) was compared to high-density dot braille (diameter 0.75 mm) wherein each normal dot was rendered by high-density simulated pins alone or in a cluster of pins configured in a diamond, X, or square; and to "blobs" that could result from covering normal braille and high-density multi-pin configurations with a thin membrane. Twelve blind participants read MNREAD sentences displayed in these conditions. For high-density simulated pins, single pins were as quickly and easily read as normal braille, but diamond, X, and square multi-pin configurations were slower and/or harder to read than normal braille. We therefore conclude that as long as center-to-center dot spacing and dot placement is maintained, the dot diameter may be open to variability for rendering braille on a high density tactile display.

  8. Failure analysis on false call probe pins of microprocessor test equipment

    NASA Astrophysics Data System (ADS)

    Tang, L. W.; Ong, N. R.; Mohamad, I. S. B.; Alcain, J. B.; Retnasamy, V.

    2017-09-01

    A study has been conducted to investigate failure analysis on probe pins of test modules for microprocessor. The `health condition' of the probe pin is determined by the resistance value. A test module of 5V power supplied from Arduino UNO with "Four-wire Ohm measurement" method is implemented in this study to measure the resistance of the probe pins of a microprocessor. The probe pins from a scrapped computer motherboard is used as the test sample in this study. The functionality of the test module was validated with the pre-measurement experiment via VEE Pro software. Lastly, the experimental work have demonstrated that the implemented test module have the capability to identify the probe pin's `health condition' based on the measured resistance value.

  9. Enquiry into the Topology of Plasma Membrane-Localized PIN Auxin Transport Components.

    PubMed

    Nodzyński, Tomasz; Vanneste, Steffen; Zwiewka, Marta; Pernisová, Markéta; Hejátko, Jan; Friml, Jiří

    2016-11-07

    Auxin directs plant ontogenesis via differential accumulation within tissues depending largely on the activity of PIN proteins that mediate auxin efflux from cells and its directional cell-to-cell transport. Regardless of the developmental importance of PINs, the structure of these transporters is poorly characterized. Here, we present experimental data concerning protein topology of plasma membrane-localized PINs. Utilizing approaches based on pH-dependent quenching of fluorescent reporters combined with immunolocalization techniques, we mapped the membrane topology of PINs and further cross-validated our results using available topology modeling software. We delineated the topology of PIN1 with two transmembrane (TM) bundles of five α-helices linked by a large intracellular loop and a C-terminus positioned outside the cytoplasm. Using constraints derived from our experimental data, we also provide an updated position of helical regions generating a verisimilitude model of PIN1. Since the canonical long PINs show a high degree of conservation in TM domains and auxin transport capacity has been demonstrated for Arabidopsis representatives of this group, this empirically enhanced topological model of PIN1 will be an important starting point for further studies on PIN structure-function relationships. In addition, we have established protocols that can be used to probe the topology of other plasma membrane proteins in plants. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Pinning Stabilizes Neighboring Surface Nanobubbles against Ostwald Ripening.

    PubMed

    Dollet, Benjamin; Lohse, Detlef

    2016-11-01

    Pinning of the contact line and gas oversaturation explain the stability of single surface nanobubbles. In this article, we theoretically show that the pinning also suppresses the Ostwald ripening process between neighboring surface nanobubbles, thus explaining why in a population of neighboring surface nanobubbles different radii of curvature of the nanobubbles can be observed.

  11. Temperature dependent pinning landscapes in REBCO thin films

    NASA Astrophysics Data System (ADS)

    Jaroszynski, Jan; Constantinescu, Anca-Monia; Hu, Xinbo Paul

    2015-03-01

    The pinning landscapes of REBCO (RE=rare earth elements) thin films have been a topic of study in recent years due to, among other reasons, their high ability to introduce various phases and defects. Pinning mechanisms studies in high temperature superconductors often require detailed knowledge of critical current density as a function of magnetic field orientation as well as field strength and temperature. Since the films can achieve remarkably high critical current, challenges exist in evaluating these low temperature (down to 4.2 K) properties in high magnetic fields up to 30 T. Therefore both conventional transport, and magnetization measurements in a vibrating coil magnetometer equipped with rotating sample platform were used to complement the study. Our results clearly show an evolution of pinning from strongly correlated effects seen at high temperatures to significant contributions from dense but weak pins that thermal fluctuations render ineffective at high temperatures but which become strong at lower temperatures Support for this work is provided by the NHMFL via NSF DRM 1157490

  12. The stress distribution in pin-loaded orthotropic plates

    NASA Technical Reports Server (NTRS)

    Klang, E. C.; Hyer, M. W.

    1985-01-01

    The performance of mechanically fastened composite joints was studied. Specially, a single-bolt connector was modeled as a pin-loaded, infinite plate. The model that was developed used two dimensional, complex variable, elasticity techniques combined with a boundary collocation procedure to produce solutions for the problem. Through iteration, the boundary conditions were satisfied and the stresses in the plate were calculated. Several graphite epoxy laminates were studied. In addition, parameters such as the pin modulus, coefficient of friction, and pin-plate clearance were varied. Conclusions drawn from this study indicate: (1) the material properties (i.e., laminate configuration) of the plate alter the stress state and, for highly orthotropic materials, the contact stress deviates greatly from the cosinusoidal distribution often assumed; (2) friction plays a major role in the distribution of stresses in the plate; (3) reversing the load direction also greatly effects the stress distribution in the plate; (4) clearance (or interference) fits change the contact angle and thus the location of the peak hoop stress; and (5) a rigid pin appears to be a good assumption for typical material systems.

  13. OsPIN5b modulates rice (Oryza sativa) plant architecture and yield by changing auxin homeostasis, transport and distribution.

    PubMed

    Lu, Guangwen; Coneva, Viktoriya; Casaretto, José A; Ying, Shan; Mahmood, Kashif; Liu, Fang; Nambara, Eiji; Bi, Yong-Mei; Rothstein, Steven J

    2015-09-01

    Plant architecture attributes such as tillering, plant height and panicle size are important agronomic traits that determine rice (Oryza sativa) productivity. Here, we report that altered auxin content, transport and distribution affect these traits, and hence rice yield. Overexpression of the auxin efflux carrier-like gene OsPIN5b causes pleiotropic effects, mainly reducing plant height, leaf and tiller number, shoot and root biomass, seed-setting rate, panicle length and yield parameters. Conversely, reduced expression of OsPIN5b results in higher tiller number, more vigorous root system, longer panicles and increased yield. We show that OsPIN5b is an endoplasmic reticulum (ER) -localized protein that participates in auxin homeostasis, transport and distribution in vivo. This work describes an example of an auxin-related gene where modulating its expression can simultaneously improve plant architecture and yield potential in rice, and reveals an important effect of hormonal signaling on these traits. © 2015 The Authors The Plant Journal © 2015 John Wiley & Sons Ltd.

  14. Tool for use in lifting pin supported objects

    NASA Technical Reports Server (NTRS)

    Marzek, R. A.; Read, W. S. (Inventor)

    1974-01-01

    A tool for use in lifting a pin-supported, electronic package mounted in juxtaposition with the surface of an electronic circuit board is described. The tool is configured to be received beneath a pin-supported package and is characterized by a manually operable linkage, including an elongated, rigid link is supported for axial reciprocation and a pivotal link pinned to the body and supported for oscillation induced in response to axial motion imparted to the rigid link. A lifting plate is pivotally coupled to the distal end of the pivotal link so that oscillatory motion imparted to the pivotal link serves to move the plate vertically for elevating the plate into lifting engagement with the electronic package positioned thereabove.

  15. Strain tunable light emitting diodes with germanium P-I-N heterojunctions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lagally, Max G; Sanchez Perez, Jose Roberto

    Tunable p-i-n diodes comprising Ge heterojunction structures are provided. Also provided are methods for making and using the tunable p-i-n diodes. Tunability is provided by adjusting the tensile strain in the p-i-n heterojunction structure, which enables the diodes to emit radiation over a range of wavelengths.

  16. Vortex dynamics in type-II superconductors under strong pinning conditions

    NASA Astrophysics Data System (ADS)

    Thomann, A. U.; Geshkenbein, V. B.; Blatter, G.

    2017-10-01

    We study effects of pinning on the dynamics of a vortex lattice in a type-II superconductor in the strong-pinning situation and determine the force-velocity (or current-voltage) characteristic combining analytical and numerical methods. Our analysis deals with a small density np of defects that act with a large force fp on the vortices, thereby inducing bistable configurations that are a characteristic feature of strong pinning theory. We determine the velocity-dependent average pinning-force density 〈Fp(v ) 〉 and find that it changes on the velocity scale vp˜fp/η a03 , where η is the viscosity of vortex motion and a0 the distance between vortices. In the small pin-density limit, this velocity is much larger than the typical flow velocity vc˜Fc/η of the free vortex system at drives near the critical force density Fc=〈Fp(v =0 ) 〉 ∝npfp . As a result, we find a generic excess-force characteristic, a nearly linear force-velocity characteristic shifted by the critical force density Fc; the linear flux-flow regime is approached only at large drives. Our analysis provides a derivation of Coulomb's law of dry friction for the case of strong vortex pinning.

  17. Parasitic nematodes modulate PIN-mediated auxin transport to facilitate infection.

    PubMed

    Grunewald, Wim; Cannoot, Bernard; Friml, Jirí; Gheysen, Godelieve

    2009-01-01

    Plant-parasitic nematodes are destructive plant pathogens that cause significant yield losses. They induce highly specialized feeding sites (NFS) in infected plant roots from which they withdraw nutrients. In order to establish these NFS, it is thought that the nematodes manipulate the molecular and physiological pathways of their hosts. Evidence is accumulating that the plant signalling molecule auxin is involved in the initiation and development of the feeding sites of sedentary plant-parasitic nematodes. Intercellular transport of auxin is essential for various aspects of plant growth and development. Here, we analysed the spatial and temporal expression of PIN auxin transporters during the early events of NFS establishment using promoter-GUS/GFP fusion lines. Additionally, single and double pin mutants were used in infection studies to analyse the role of the different PIN proteins during cyst nematode infection. Based on our results, we postulate a model in which PIN1-mediated auxin transport is needed to deliver auxin to the initial syncytial cell, whereas PIN3 and PIN4 distribute the accumulated auxin laterally and are involved in the radial expansion of the NFS. Our data demonstrate that cyst nematodes are able to hijack the auxin distribution network in order to facilitate the infection process.

  18. A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways.

    PubMed

    Yang, Dayun; Luo, Wensong; Wang, Jichuang; Zheng, Min; Liao, Xin-Hua; Zhang, Nan; Lu, Wenxian; Wang, Long; Chen, Ai-Zheng; Wu, Wen-Guo; Liu, Hekun; Wang, Shi-Bin; Zhou, Xiao Zhen; Lu, Kun Ping

    2018-01-10

    Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide largely due to lack of effective targeted drugs to simultaneously block multiple cancer-driving pathways. The identification of all-trans retinoic acid (ATRA) as a potent Pin1 inhibitor provides a promising candidate for HCC targeted therapy because Pin1 is overexpressed in most HCC and activates numerous cancer-driving pathways. However, the efficacy of ATRA against solid tumors is limited due to its short half-life of 45min in humans. A slow-releasing ATRA formulation inhibits solid tumors such as HCC, but can be used only in animals. Here, we developed a one-step, cost-effective route to produce a novel biocompatible, biodegradable, and non-toxic controlled release formulation of ATRA for effective HCC therapy. We used supercritical carbon dioxide process to encapsulate ATRA in largely uniform poly L-lactic acid (PLLA) microparticles, with the efficiency of 91.4% and yield of 68.3%, and ~4-fold higher C max and AUC over the slow-releasing ATRA formulation. ATRA-PLLA microparticles had good biocompatibility, and significantly enhanced the inhibitory potency of ATRA on HCC cell growth, improving IC 50 by over 3-fold. ATRA-PLLA microparticles exerted its efficacy likely through degrading Pin1 and inhibiting multiple Pin1-regulated cancer pathways and cell cycle progression. Indeed, Pin1 knock-down abolished ATRA inhibitory effects on HCC cells and ATRA-PLLA did not inhibit normal liver cells, as expected because ATRA selectively inhibits active Pin1 in cancer cells. Moreover ATRA-PLLA microparticles significantly enhanced the efficacy of ATRA against HCC tumor growth in mice through reducing Pin1, with a better potency than the slow-releasing ATRA formulation, consistent with its improved pharmacokinetic profiles. This study illustrates an effective platform to produce controlled release formulation of anti-cancer drugs, and ATRA-PLLA microparticles might be a promising targeted

  19. Generation of spiral waves pinned to obstacles in a simulated excitable system

    NASA Astrophysics Data System (ADS)

    Phantu, Metinee; Kumchaiseemak, Nakorn; Porjai, Porramain; Sutthiopad, Malee; Müller, Stefan C.; Luengviriya, Chaiya; Luengviriya, Jiraporn

    2017-09-01

    Pinning phenomena emerge in many dynamical systems. They are found to stabilize extreme conditions such as superconductivity and super fluidity. The dynamics of pinned spiral waves, whose tips trace the boundary of obstacles, also play an important role in the human health. In heart, such pinned waves cause longer tachycardia. In this article, we present two methods for generating pinned spiral waves in a simulated excitable system. In method A, an obstacle is set in the system prior to an ignition of a spiral wave. This method may be suitable only for the case of large obstacles since it often fails when used for small obstacles. In method B, a spiral wave is generated before an obstacle is placed at the spiral tip. With this method, a pinned spiral wave is always obtained, regardless the obstacle size. We demonstrate that after a transient interval the dynamics of the pinned spiral waves generated by the methods A and B are identical. The initiation of pinned spiral waves in both two- and three-dimensional systems is illustrated.

  20. Magnetoresistive detection of strongly pinned uncompensated magnetization in antiferromagnetic FeMn

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lapa, Pavel N.; Roshchin, Igor V.; Ding, Junjia

    2017-01-17

    Here we observed and studied pinned uncompensated magnetization in an antiferromagnet using magnetoresistance measurements. For this, we developed antiferromagnet-ferromagnet spin valves (AFSVs) that consist of an antiferromagnetic layer and a ferromagnetic one, separated by a nonmagnetic conducting spacer. In an AFSV, the uncompensated magnetization in the antiferromagnet affects scattering of spin-polarized electrons giving rise to giant magnetoresitance (GMR). By measuring angular dependence of AFSVs' resistance, we detected pinned uncompensated magnetization responsible for the exchange bias effect in an antiferromagnet- only exchange bias system Cu/FeMn/Cu. The fact that GMR measured in this system persists up to 110 kOe indicates that themore » scattering occurs on strongly pinned uncompensated magnetic moments in FeMn. This strong pinning can be explained if this pinned uncompensated magnetization is a thermodynamically stable state and coupled to the antiferromagnetic order parameter. Finally, using the AFSV technique, we confirmed that the two interfaces between FeMn and Cu are magnetically different: The uncompensated magnetization is pinned only at the interface with the bottom Cu layer.« less

  1. Garan conducts CsPINs Experiment Operations

    NASA Image and Video Library

    2011-04-28

    ISS027-E-017843 (28 April 2011) --- NASA astronaut Ron Garan, Expedition 27 flight engineer, supports the Dynamism of Auxin Efflux Facilitators responsible for Gravity-regulated Growth and Development in Cucumber (CsPINs) experiment in the Kibo laboratory of the International Space Station. CsPINs studies the phenomenon of tropism, i.e., the growth or turning movement of a biological organism, usually a plant, in response to an environmental stimulus. Specifically focusing on gravity, the new JAXA life science experiment investigates how plants sense gravity as an environmental signal and use it for governing their morphology and growth orientation.

  2. Garan conducts CsPINs Experiment Operations

    NASA Image and Video Library

    2011-04-28

    ISS027-E-017840 (28 April 2011) --- NASA astronaut Ron Garan, Expedition 27 flight engineer, supports the Dynamism of Auxin Efflux Facilitators responsible for Gravity-regulated Growth and Development in Cucumber (CsPINs) experiment in the Kibo laboratory of the International Space Station. CsPINs studies the phenomenon of tropism, i.e., the growth or turning movement of a biological organism, usually a plant, in response to an environmental stimulus. Specifically focusing on gravity, the new JAXA life science experiment investigates how plants sense gravity as an environmental signal and use it for governing their morphology and growth orientation.

  3. Garan conducts CsPINs Experiment Operations

    NASA Image and Video Library

    2011-04-28

    ISS027-E-017839 (28 April 2011) --- NASA astronaut Ron Garan, Expedition 27 flight engineer, supports the Dynamism of Auxin Efflux Facilitators responsible for Gravity-regulated Growth and Development in Cucumber (CsPINs) experiment in the Kibo laboratory of the International Space Station. CsPINs studies the phenomenon of tropism, i.e., the growth or turning movement of a biological organism, usually a plant, in response to an environmental stimulus. Specifically focusing on gravity, the new JAXA life science experiment investigates how plants sense gravity as an environmental signal and use it for governing their morphology and growth orientation.

  4. High-Temperature High-Current Superconductors: Preparation, Structure, Superconducting Properties, and Flux-Pinning Mechanisms

    NASA Astrophysics Data System (ADS)

    Hu, Shouxiang

    In bulk high-T_{rm c } superconductors, weak links at the grain boundaries and weak flux pinning are the two major causes of low critical current density (J_{ rm c}) at 77 K. In the present study, various processes designed and developed to address these problems are discussed. The novel pressurized-partial -melt-growth process, which leads to a relatively large improvement in the microstructure as well as in the superconducting properties of bulk Y-Ba-Cu-O superconductors, is described. The effects of introducing foreign elements to serve as pinning centers are reported, and the associated anomalous superconducting phenomena are explained on the basis of a detailed study of basic pinning mechanisms related to the presence of small defects. It is demonstrated that in certain cases the pinning force induced by the compression of the vortex line may be comparable to, or even larger than, the usually recognized pinning force due to the condensation energy. Studies of the pinning mechanism corresponding to large boundary defects show that boundary defects associated with certain non-superconducting inclusions and isolated weak links have a very positive role in the enhancement of both the critical current density and the effective activation energy for flux creep. However, even optimized theoretical estimates show that it will be difficult to reach J_ {rm c} values of 5 times 10^5 A/cm^2 at 77 K and H = 1 T by increasing the number of Y_2BaCuO inclusions alone. Although even higher J_{rm c} values may be achieved by introducing other types of defects using alternative approaches such as irradiation, and, probably, chemical doping, the presence of large amount of boundary defects is very important in causing a large increase in the effective activation energy for flux creep. Also studied are the anisotropic electromagnetic features of the grain-aligned YBa_2Cu _3O_{rm x} bulk superconductors. The development of novel processing methods guided by improved understanding

  5. NHEXAS PHASE I MARYLAND STUDY--STANDARD OPERATING PROCEDURE FOR IDENTIFICATION NUMBERS FOR SAMPLES AND FORMS (G03)

    EPA Science Inventory

    The purpose of this SOP is to indicate the proper method for assigning unique Identification Numbers for all samples taken and forms used in the collection of NHEXAS Pilot Studies. All data tracking procedures were built upon these ID numbers. Inspection of these ID numbers pro...

  6. Pinning in BSCCO above the ordinary irreversibility line

    NASA Astrophysics Data System (ADS)

    Indenbom, M. V.; van der Beek, C. J.; Berseth, V.; Konczykowski, M.; Motohira, N.; Berger, H.; Benoit, W.

    1996-12-01

    Frequency-dependent observations of magnetic flux structures are used to show that pinning plays a principal role in the whole mixed state in Bi2Sr2CaCu2O8 (BSCCO) single crystals. We speculate that the random pinning force on the moving vortices may dominate over thermal fluctuations and considerably modify the position of the vortex lattice phase transition.

  7. IMp: The customizable LEGO(®) Pinned Insect Manipulator.

    PubMed

    Dupont, Steen; Price, Benjamin; Blagoderov, Vladimir

    2015-01-01

    We present a pinned insect manipulator (IMp) constructed of LEGO® building bricks with two axes of movement and two axes of rotation. In addition we present three variants of the IMp to emphasise the modular design, which facilitates resizing to meet the full range of pinned insect specimens, is fully customizable, collapsible, affordable and does not require specialist tools or knowledge to assemble.

  8. A Flux-Pinning Mechanism for Segment Assembly and Alignment

    NASA Technical Reports Server (NTRS)

    Gersh-Range, Jessica A.; Arnold, William R.; Peck, Mason A.; Stahl, H. Philip

    2011-01-01

    Currently, the most compelling astrophysics questions include how planets and the first stars formed and whether there are protostellar disks that contain large organic molecules. Although answering these questions requires space telescopes with apertures of at least 10 meters, such large primaries are challenging to construct by scaling up previous designs; the limited capacity of a launch vehicle bounds the maximum diameter of a monolithic primary, and beyond a certain size, deployable telescopes cannot fit in current launch vehicle fairings. One potential solution is connecting the primary mirror segments edgewise using flux-pinning mechanisms, which are analogous to non-contacting damped springs. In the baseline design, a flux-pinning mechanism consists of a magnet and a superconductor separated by a predetermined gap, with the damping adjusted by placing aluminum near the interface. Since flux pinning is possible only when the superconductor is cooled below a critical temperature, flux-pinning mechanisms are uniquely suited for cryogenic space telescopes. By placing these mechanisms along the edges of the mirror segments, a primary can be built up over time. Since flux pinning requires no mechanical deployments, the assembly process could be robotic or use some other non-contacting scheme. Advantages of this approach include scalability and passive stability.

  9. Improved protease stability of the antimicrobial peptide Pin2 substituted with D-amino acids.

    PubMed

    Carmona, G; Rodriguez, A; Juarez, D; Corzo, G; Villegas, E

    2013-08-01

    Cationic antimicrobial peptides (AMPs) have attracted a great interest as novel class of antibiotics that might help in the treatment of infectious diseases caused by pathogenic bacteria. However, some AMPs with high antimicrobial activities are also highly hemolytic and subject to proteolytic degradation from human and bacterial proteases that limit their pharmaceutical uses. In this work a D-diastereomer of Pandinin 2, D-Pin2, was constructed to observe if it maintained antimicrobial activity in the same range as the parental one, but with the purpose of reducing its hemolytic activity to human erythrocytes and improving its ability to resist proteolytic cleavage. Although, the hydrophobic and secondary structure characteristics of L- and D-Pin2 were to some extent similar, an important reduction in D-Pin2 hemolytic activity (30-40 %) was achieved compared to that of L-Pin2 over human erythrocytes. Furthermore, D-Pin2 had an antimicrobial activity with a MIC value of 12.5 μM towards Staphylococcus aureus, Escherichia coli, Streptococcus agalactiae and two strains of Pseudomonas aeruginosa in agar diffusion assays, but it was half less potent than that of L-Pin2. Nevertheless, the antimicrobial activity of D-Pin2 was equally effective as that of L-Pin2 in microdilution assays. Yet, when D- and L-Pin2 were incubated with trypsin, elastase and whole human serum, only D-Pin2 kept its antimicrobial activity towards all bacteria, but in diluted human serum, L- and D-Pin2 maintained similar peptide stability. Finally, when L- and D-Pin2 were incubated with proteases from P. aeruginosa DFU3 culture, a clinical isolated strain, D-Pin2 kept its antibiotic activity while L-Pin2 was not effective.

  10. Finite Element Analysis of Laser Engineered Net Shape (LENS™) Tungsten Clad Squeeze Pins

    NASA Astrophysics Data System (ADS)

    Sakhuja, Amit; Brevick, Jerald R.

    2004-06-01

    In the aluminum high-pressure die-casting and indirect squeeze casting processes, local "squeeze" pins are often used to minimize internal solidification shrinkage in heavy casting sections. Squeeze pins frequently fail in service due to molten aluminum adhering to the H13 tool steel pins ("soldering"). A wide variety of coating materials and methods have been developed to minimize soldering on H13. However, these coatings are typically very thin, and experience has shown their performance on squeeze pins is highly variable. The LENS™ process was employed in this research to deposit a relatively thick tungsten cladding on squeeze pins. An advantage of this process was that the process parameters could be precisely controlled in order to produce a satisfactory cladding. Two fixtures were designed and constructed to enable the end and outer diameter (OD) of the squeeze pins to be clad. Analyses were performed on the clad pins to evaluate the microstructure and chemical composition of the tungsten cladding and the cladding-H13 substrate interface. A thermo-mechanical finite element analysis (FEA) was performed to assess the stress distribution as a function of cladding thickness on the pins during a typical casting thermal cycle. FEA results were validated via a physical test, where the clad squeeze pins were immersed into molten aluminum. Pins subjected to the test were evaluated for thermally induced cracking and resistance to soldering of the tungsten cladding.

  11. 78 FR 18343 - Federal Acquisition Regulation; Submission for OMB Review; Taxpayer Identification Number...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... agency is required to furnish its Tax Identification Number (TIN) to that agency. 31 U.S.C. 3325(d... and submitted to a disbursing official, the TIN of the contractor receiving payment under the voucher... other information, its TIN. The TIN may be used by the Government to collect and report on any...

  12. Fabrication of fuel pin assemblies, phase 3

    NASA Technical Reports Server (NTRS)

    Keeton, A. R.; Stemann, L. G.

    1972-01-01

    Five full size and eight reduced length fuel pins were fabricated for irradiation testing to evaluate design concepts for a fast spectrum lithium cooled compact space power reactor. These assemblies consisted of uranium mononitride fuel pellets encased in a T-111 (Ta-8W-2Hf) clad with a tungsten barrier separating fuel and clad. Fabrication procedures were fully qualified by process development and assembly qualification tests. Detailed specifications and procedures were written for the fabrication and assembly of prototype fuel pins.

  13. The connection characteristics of flux pinned docking interface

    NASA Astrophysics Data System (ADS)

    Zhang, Mingliang; Han, Yanjun; Guo, Xing; Zhao, Cunbao; Deng, Feiyue

    2017-03-01

    This paper presents the mechanism and potential advantages of flux pinned docking interface mainly composed of a high temperature superconductor and an electromagnet. In order to readily assess the connection characteristics of flux pinned docking interface, the force between a high temperature superconductor and an electromagnet needs to be investigated. Based on the magnetic dipole method and the Ampere law method, the force between two current coils can be compared, which shows that the Ampere law method has the higher calculated accuracy. Based on the improved frozen image model and the Ampere law method, the force between high temperature superconductor bulk and permanent magnet can be calculated, which is validated experimentally. Moreover, the force between high temperature superconductor and electromagnet applied to flux pinned docking interface is able to be predicted and analyzed. The connection stiffness between high temperature superconductor and permanent magnet can be calculated based on the improved frozen image model and Hooke's law. The relationship between the connection stiffness and field cooling height is analyzed. Furthermore, the connection stiffness of the flux pinned docking interface is predicted and optimized, and its effective working range is defined and analyzed in case of some different parameters.

  14. Investigation into Z-Pin Reinforced Composite Skin/Stiffener Debond under Monotonic and Cyclic Bending

    NASA Astrophysics Data System (ADS)

    Zhang, Xiangyang; Li, Yong; Van Hoa, Suong; Xiao, Jun; Chu, Qiyi

    2018-02-01

    Skin/stiffener debonding has been a longstanding concern for the users of stiffened composite panels in long-term service. Z-pinning technology is an emerging solution to reinforce the composite assembly joints. This work experimentally characterizes the progressive debonding of Z-pinned skin/stiffener interface with the skin under static bend loading. The three-stage failure process is identified as: flange edge debonding, pin/laminate debonding, and ultimate structural failure. Three different distribution patterns were compared in terms of the static debonding properties revealed the affirmative fact that locating pins in high normal stress regions, that is close to the flange edges in skin/stiffener structures, is more beneficial to utilize the full potential of Z-pinning reinforcement. The unit strip FE model was developed and demonstrated effective to analysis the effect of Z-pin distribution on the ultimate debond load. On the other hand, the evolution of fatigue cracks at Z-pinned skin/flange interface was investigated with a series of displacement-controlled fatigue bending tests and microscopic observations. Results show that Z-pinning postpones crack initiations at low displacement levels, and the remarkable crack-arresting function of pins enables the structure a prolonged fatigue life. However, pins become less effective when the maximum displacement exceeds the crack initiation level due to gradually pullout of pins.

  15. Calcaneal traction pin placement simplified: a cadaveric study.

    PubMed

    Kwon, John Y; Ellington, J Kent; Marsland, Daniel; Gupta, Sanjeev

    2011-06-01

    The tibial neurovascular bundle and sural nerve are at risk with errant pin placement during transcalcaneal pin placement. The purpose of this study was to determine a relative safe zone using a single osseous landmark to establish a technique applicable in the presence of trauma. We describe the neural anatomy anatomically and radiographically, giving surgeons a reliable and relatively safe technique for transcalcaneal pin placement. Twenty-four cadavers were dissected for the major medial neurovascular structures and the sural nerve. The closest distance from the neurovascular structures to the posterior inferior calcaneus was measured. The mean distance from the posterior inferior calcaneus to the closest major medial neurovascular structure was 3.4 cm (SD ± 0.36; range, 2.6 to 4.1 cm). The mean distance to the sural nerve was 3.4 cm (SD ± 0.54; range, 2.3 to 4.6 cm). According to the 95% confidence intervals, a relative safe zone of 3.1 cm as a radius from the posterior inferior calcaneus was determined. A relatively safe zone of 3.1 cm based on 95% confidence intervals as described as a radius from the posterior inferior calcaneus can be used for transcalcaneal pin placement in most cases without injury to the medial neurovascular bundle or sural nerve. However anatomic variation may result in the neurovascular bundle being within this zone. We describe a surgical technique for reliable placement of a transcalcaneal pin within this relative safe zone and a safe distance from the closest neurovascular structure.

  16. Experimental and numerical study of Bondura® 6.6 PIN joints

    NASA Astrophysics Data System (ADS)

    Berkani, I.; Karlsen, Ø.; Lemu, H. G.

    2017-12-01

    Pin joints are widely used in heavy-duty machinery such as aircrafts, cranes and offshore drilling equipment to transfer multi-dimensional shear forces. Their strength and service life depend on the clamping force in the contact region that is provided by interference fits. Though the interference fits provide full contact at the pin-hole interface under pretension loads, the contact interface reduces when the pin is subjected to an external load and hence a smaller contact surface leads to dramatic increase of the contact stress. The PIN joint of Bondura® Technology, investigated in this study, is an innovative solution intended to reduce the slack at the contact surface of the pin joint of heavy-duty machinery by using tapered sleeves on each end of the PIN. The study is aimed to better understand the contact pressure build-up and stress distribution in the supporting contact surface under pre-loading of the joint and the influence of temperature difference between part assembly and operation conditions. Numerical simulation using finite element method and diverse experimental tests were conducted. The numerical simulation and the test results, particularly the tests conducted with lubricated joints, show good conformance.

  17. Campbell response in type-II superconductors under strong pinning conditions

    DOE PAGES

    Willa, R.; Geshkenbein, V. B.; Prozorov, R.; ...

    2015-11-11

    Measuring the ac magnetic response of a type II superconductor provides valuable information on the pinning landscape (pinscape) of the material. We use strong pinning theory to derive a microscopic expression for the Campbell length λC, the penetration depth of the ac signal. We show that λ C is determined by the jump in the pinning force, in contrast to the critical current j c, which involves the jump in pinning energy. We demonstrate that the Campbell lengths generically differ for zero-field-cooled and field-cooled samples and predict that hysteretic behavior can appear in the latter situation. As a result, wemore » compare our findings with new experimental data and show the potential of this technique in providing information on the material’s pinscape.« less

  18. Campbell response in type-II superconductors under strong pinning conditions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Willa, R.; Geshkenbein, V. B.; Prozorov, R.

    Measuring the ac magnetic response of a type II superconductor provides valuable information on the pinning landscape (pinscape) of the material. We use strong pinning theory to derive a microscopic expression for the Campbell length λC, the penetration depth of the ac signal. We show that λ C is determined by the jump in the pinning force, in contrast to the critical current j c, which involves the jump in pinning energy. We demonstrate that the Campbell lengths generically differ for zero-field-cooled and field-cooled samples and predict that hysteretic behavior can appear in the latter situation. As a result, wemore » compare our findings with new experimental data and show the potential of this technique in providing information on the material’s pinscape.« less

  19. Charge transport properties of intrinsic layer in diamond vertical pin diode

    NASA Astrophysics Data System (ADS)

    Shimaoka, Takehiro; Kuwabara, Daisuke; Hara, Asuka; Makino, Toshiharu; Tanaka, Manobu; Koizumi, Satoshi

    2017-05-01

    Diamond is hoped to be utilized in ultimate power electronic devices exhibiting ultra-high blocking voltages. For practical device formation, it is important to characterize the electric properties to precisely simulate carrier transport and to practically design optimum device structures. In this study, we experimentally evaluated the charge transport properties of intrinsic layers in diamond vertical pin diodes using alpha-particle induced charge distribution measurements. The charge collection efficiencies were 98.1 ± 0.6% for a {111} pin diode and 96.9 ± 0.6% for a {100} pin diode, which means that almost all generated charges are collected accordingly equivalent to conventional Silicon pin photodiodes. Mobility-lifetime (μτ) products of holes were (2.2 ± 0.3) × 10-6 cm2/V for {111} and (1.8 ± 0.1) × 10-5 cm2/V for {100} diamond pin diodes.

  20. 24 CFR 203.35 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Social Security and Employer Identification Numbers. 203.35 Section 203.35 Housing and Urban Development... Requirements and Underwriting Procedures Eligible Mortgagors § 203.35 Disclosure and verification of Social... mortgagor must meet the requirements for the disclosure and verification of Social Security and Employer...

  1. 24 CFR 203.35 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Social Security and Employer Identification Numbers. 203.35 Section 203.35 Housing and Urban Development... Requirements and Underwriting Procedures Eligible Mortgagors § 203.35 Disclosure and verification of Social... mortgagor must meet the requirements for the disclosure and verification of Social Security and Employer...

  2. 24 CFR 203.35 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Social Security and Employer Identification Numbers. 203.35 Section 203.35 Housing and Urban Development... Requirements and Underwriting Procedures Eligible Mortgagors § 203.35 Disclosure and verification of Social... mortgagor must meet the requirements for the disclosure and verification of Social Security and Employer...

  3. 24 CFR 203.35 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Social Security and Employer Identification Numbers. 203.35 Section 203.35 Housing and Urban Development... Requirements and Underwriting Procedures Eligible Mortgagors § 203.35 Disclosure and verification of Social... mortgagor must meet the requirements for the disclosure and verification of Social Security and Employer...

  4. 24 CFR 203.35 - Disclosure and verification of Social Security and Employer Identification Numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Social Security and Employer Identification Numbers. 203.35 Section 203.35 Housing and Urban Development... Requirements and Underwriting Procedures Eligible Mortgagors § 203.35 Disclosure and verification of Social... mortgagor must meet the requirements for the disclosure and verification of Social Security and Employer...

  5. The Effect of Insertion Technique on Temperatures for Standard and Self-Drilling External Fixation Pins.

    PubMed

    Manoogian, Sarah; Lee, Adam K; Widmaier, James C

    2017-08-01

    No studies have assessed the effects of parameters associated with insertion temperature in modern self-drilling external fixation pins. The current study assessed how varying the presence of irrigation, insertion speed, and force impacted the insertion temperatures of 2 types of standard and self-drilling external fixation half pins. Seventy tests were conducted with 10 trials for 4 conditions on self-drilling pins, and 3 conditions for standard pins. Each test used a thermocouple inside the pin to measure temperature rise during insertion. Adding irrigation to the standard pin insertion significantly lowered the maximum temperature (P <0.001). Lowering the applied force for the standard pin did not have a significant change in temperature rise. Applying irrigation during the self-drilling pin tests dropped average rise in temperature from 151.3 ± 21.6°C to 124.1 ± 15.3°C (P = 0.005). When the self-drilling pin insertion was decreased considerably from 360 to 60 rpm, the temperature decreased significantly from 151.3 ± 21.6°C to 109.6 ± 14.0°C (P <0.001). When the force applied increased significantly, the corresponding self-drilling pin temperature increase was not significant. The standard pin had lower peak temperatures than the self-drilling pin for all conditions. Moreover, slowing down the insertion speed and adding irrigation helped mitigate the temperature increase of both pin types during insertion.

  6. Turban pin aspiration: new fashion, new syndrome.

    PubMed

    Ilan, Ophir; Eliashar, Ron; Hirshoren, Nir; Hamdan, Kasem; Gross, Menachem

    2012-04-01

    Turban pin aspiration syndrome is a new clinical entity afflicting young Islamic girls wearing a turban.The goal of this study was to present our experience in diagnosis and treatment of this new entity, define its clinical and epidemiologic features, and shed a new light on the role of fashion in the increased incidence. A retrospective study in a tertiary university hospital. Review of clinical parameters and epidemiologic features of 26 patients diagnosed with turban pin aspiration syndrome admitted to the Hadassah-Hebrew University Hospitals in Jerusalem from 1990 to 2010. All patients were Muslim females with an average age of 16 years. In all cases, the history was positive for accidental aspiration. Most of the pins were located in the trachea (42%). In 20 cases, the pins were extracted by rigid bronchoscopy without major complications. Fluoroscopy-assisted rigid bronchoscopy was used successfully in three cases. In one case, the object was self-ejected by coughing before the bronchoscopy, and two patients were referred to the chest unit for thoracotomy. Clinicians should be aware of this distinct form of foreign body aspiration, its method of diagnosis, and extraction techniques. A cultural investigation showed a difference in the turban-fastening technique of young girls as compared with their mothers. Removal by rigid bronchoscopy is a safe method with a high success rate and should be considered as the preferred extraction method of choice. Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

  7. Fracture Analysis of 40Cr Steel Pin Roll

    NASA Astrophysics Data System (ADS)

    Li, Yong; Jia, Youlu; Xie, Xianjiao

    2018-01-01

    Fracture of 40Cr steel pin roll happened along the cross-section at the spot of filling aperture. By the use of analysis of optical microscopy and microhardness, it can be known that filling aperture and its nitration case (ε phase) and large amounts of non-metal inclusions (bulk obscure inclusions) in steel were the main reasons which led to the facture of 40Cr steel pin roll.

  8. Electrically controlled pinning of Dzyaloshinskii-Moriya domain walls

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sato, Koji; Tretiakov, Oleg A., E-mail: olegt@imr.tohoku.ac.jp; School of Natural Sciences, Far Eastern Federal University, Vladivostok 690950

    We propose a method to all-electrically control a domain-wall position in a ferromagnetic nanowire with Dzyaloshinskii-Moriya interaction. The strength of this interaction can be controlled by an external electric field, which in turn allows a fine tuning of the pinning potential of a spin-spiral domain wall. It allows to create more mobile pinning sites and can also be advantageous for ultra-low power electronics.

  9. Irradiation of TZM: Uranium dioxide fuel pin at 1700 K

    NASA Technical Reports Server (NTRS)

    Mcdonald, G. E.

    1973-01-01

    A fuel pin clad with TZM and containing solid pellets of uranium dioxide was fission heated in a static helium-cooled capsule at a maximum surface temperature of 1700 K for approximately 1000 hr and to a total burnup of 2.0 percent of the uranium-235. The results of the postirradiation examination indicated: (1) A transverse, intergranular failure of the fuel pin occurred when the fuel pin reached 2.0-percent burnup. This corresponds to 1330 kW-hr/cu cm, where the volume is the sum of the fuel, clad, and void volumes in the fuel region. (2) The maximum swelling of the fuel pin was less than 1.5 percent on the fuel-pin diameter. (3) There was no visible interaction between the TZM clad and the UO2. (4) Irradiation at 1700 K produced a course-grained structure, with an average grain diameter of 0.02 centimeter and with some of the grains extending one-half of the thickness of the clad. (5) Below approximately 1500 K, the irradiation of the clad produced a moderately fine-grained structure, with an average grain diameter of 0.004 centimeter.

  10. Interaction between Pin1 and its natural product inhibitor epigallocatechin-3-gallate by spectroscopy and molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Xi, Lei; Wang, Yu; He, Qing; Zhang, Qingyan; Du, Linfang

    2016-12-01

    The binding of epigallocatechin-3-gallate (EGCG) to wild type Pin1 in solution was studied by spectroscopic methods and molecular dynamics simulations in this research to explore the binding mode and inhibition mechanism. The binding constants and number of binding sites per Pin1 for EGCG were calculated through the Stern-Volmer equation. The values of binding free energy and thermodynamic parameters were calculated and indicated that hydrogen bonds, electrostatic interaction and Van der Waals interaction played the major role in the binding process. The alterations of Pin1 secondary structure in the presence of EGCG were confirmed by far-UV circular dichroism spectra. The binding model at atomic-level revealed that EGCG was bound to the Glu12, Lys13, Arg14, Met15 and Arg17 in WW domain. Furthermore, EGCG could also interact with Arg69, Asp112, Cys113 and Ser114 in PPIase domain.

  11. GNOM regulates root hydrotropism and phototropism independently of PIN-mediated auxin transport.

    PubMed

    Moriwaki, Teppei; Miyazawa, Yutaka; Fujii, Nobuharu; Takahashi, Hideyuki

    2014-02-01

    Plant roots exhibit tropisms in response to gravity, unilateral light and moisture gradients. During gravitropism, an auxin gradient is established by PIN auxin transporters, leading to asymmetric growth. GNOM, a guanine nucleotide exchange factor of ARF GTPase (ARF-GEF), regulates PIN localization by regulating subcellular trafficking of PINs. Therefore, GNOM is important for gravitropism. We previously isolated mizu-kussei2 (miz2), which lacks hydrotropic responses; MIZ2 is allelic to GNOM. Since PIN proteins are not required for root hydrotropism in Arabidopsis, the role of GNOM in root hydrotropism should differ from that in gravitropism. To examine this possibility, we conducted genetic analysis of gnom(miz2) and gnom trans-heterozygotes. The mutant gnom(miz2), which lacks hydrotropic responses, was partially recovered by gnom(emb30-1), which lacks GEF activity, but not by gnom(B4049), which lacks heterotypic domain interactions. Furthermore, the phototropic response of gnom trans-heterozygotes differed from that of the pin2 mutant allele eir1-1. Moreover, defects in the polarities of PIN2 and auxin distribution in a severe gnom mutant were recovered by gnom(miz2). Therefore, an unknown GNOM-mediated vesicle trafficking system may mediate root hydrotropism and phototropism independently of PIN trafficking. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  12. Vortex pinning in artificially layered Ba(Fe,Co)2As2 film

    NASA Astrophysics Data System (ADS)

    Oh, M. J.; Lee, Jongmin; Seo, Sehun; Yoon, Sejun; Seo, M. S.; Park, S. Y.; Kim, Ho-Sup; Ha, Dong-Woo; Lee, Sanghan; Jo, Youn Jung

    2018-06-01

    Static high critical current densities (Jc) > 1 MA/cm2 with magnetic field parallel or perpendicular to c-axis were realized in Co-doped/undoped multilayerd BaFe2As2 films. We made a current bridge by FIB to allow precise measurements, and confirmed that the boundary quality using FIB was considerably better than the quality achieved using a laser. The presence of a high in-plane Jc suggested the existence of c-axis correlated vortex pinning centers. To clarify the relationship between the Jc performance and superstructures, we investigated the magnetic flux pinning mechanism using scaling theory of the volume pinning force Fp(H). The Jc(H) curves, Fp/Fp,max vs. h = H/Hirr curves, and parameters p and q depended on the characteristics of the flux pinning mechanism. It was found that the dominant pinning mechanism of Co-doped/undoped multilayerd BaFe2As2 films was Δl-pinning and the inserted undoped BaFe2As2 layers remained non-superconducting. The dominant pin geometry varied when the magnetic field direction changed. It was concluded that the artificially layered BaFe2As2 film is a 3-D superconductor due to its long correlation length compared to the thickness of the non-superconducting layer.

  13. Effects of low-modulus coatings on pin-bone contact stresses in external fixation.

    PubMed

    Manley, M T; Hurst, L; Hindes, R; Dee, R; Chiang, F P

    1984-01-01

    The intent of this study was to investigate the stress distribution in cortical bone around fracture fixation pins and around pins coated with various polymeric and elastomeric materials. Since these interface stresses cannot be measured directly, a photoelastic technique was employed and stresses were measured in two-dimensional bone models fabricated from sheets of epoxy resin. Our results showed that when a fixation pin was loaded in compression, the compressive stress measured in the model was greatest at the pin-model interface. The magnitude of the compressive stress was found to diminish steeply away from the hole in a log decrement distribution which was asymptotic to the value of the average stress in the model. When polymeric and elastomeric materials were applied as pin coatings and the performance of the coated pins was compared to that of uncoated pins of the same overall diameter, a reduction of the maximum stress in the bone model was demonstrated. Among the coatings tested, we found that of the polymeric materials ultrahigh molecular weight polyethylene (UHMWPE) was most effective at reducing the peak cortical stress magnitude. The most effective coating material overall was found to be silicon elastomer. Computation of stress values in models loaded through stainless-steel pins and through pins coated with 1-mm silicon elastomer showed that the presence of the elastomer layer caused a reduction of about 50% in the maximum compressive stress in the model.

  14. Joining of aluminum sheet and glass fiber reinforced polymer using extruded pins

    NASA Astrophysics Data System (ADS)

    Conte, Romina; Buhl, Johannes; Ambrogio, Giuseppina; Bambach, Markus

    2018-05-01

    The present contribution proposes a new approach for joining sheet metal and fiber reinforced composites. The joining process draws upon a Friction Stir Forming (FSF) process, which is performed on the metal sheet to produce slender pins. These pins are used to pierce through the composite. Joining is complete by forming a locking head out of the part if the pin sticks out of the composite. Pins of different diameters and lengths were produced from EN AW-1050 material, which were joined to glass fiber reinforced polyamide-6. The strength of the joint has been experimentally tested in order to understand the effect of the process temperature on the pins strength and therefore on the joining. The results demonstrate the feasibility of this new technique, which uses no excess material.

  15. Pin Tool Geometry Effects in Friction Stir Welding

    NASA Technical Reports Server (NTRS)

    Querin, J. A.; Rubisoff, H. A.; Schneider, J. A.

    2009-01-01

    In friction stir welding (FSW) there is significant evidence that material can take one of two different flow paths when being displaced from its original position in front of the pin tool to its final position in the wake of the weld. The geometry of the pin tool, along with the process parameters, plays an important role in dictating the path that the material takes. Each flow path will impart a different thermomechanical history on the material, consequently altering the material microstructure and subsequent weld properties. The intention of this research is to isolate the effect that different pin tool attributes have on the flow paths imparted on the FSWed material. Based on published weld tool geometries, a variety of weld tools were fabricated and used to join AA2219. Results from the tensile properties and microstructural characterization will be presented.

  16. Resolving the Pinning Force of Nanobubbles with Optical Microscopy

    NASA Astrophysics Data System (ADS)

    Tan, Beng Hau; An, Hongjie; Ohl, Claus-Dieter

    2017-02-01

    Many of the remarkable properties of surface nanobubbles, such as unusually small contact angles and long lifetimes, are related to the force that pins them onto their substrates. This pinning force is yet to be quantified experimentally. Here, surface-attached nanobubbles are pulled with an atomic force microscope tip while their mechanical responses are observed with total internal reflection fluorescence microscopy. We estimate that a pinning force on the order of 0.1 μ N is required to unpin a nanobubble from its substrate. The maximum force that the tip can exert on the nanobubble is limited by the stability of the neck pulled from the bubble and is enhanced by the hydrophobicity of the tip.

  17. Identification of Copy Number Aberrations in Breast Cancer Subtypes Using Persistence Topology

    PubMed Central

    Arsuaga, Javier; Borrman, Tyler; Cavalcante, Raymond; Gonzalez, Georgina; Park, Catherine

    2015-01-01

    DNA copy number aberrations (CNAs) are of biological and medical interest because they help identify regulatory mechanisms underlying tumor initiation and evolution. Identification of tumor-driving CNAs (driver CNAs) however remains a challenging task, because they are frequently hidden by CNAs that are the product of random events that take place during tumor evolution. Experimental detection of CNAs is commonly accomplished through array comparative genomic hybridization (aCGH) assays followed by supervised and/or unsupervised statistical methods that combine the segmented profiles of all patients to identify driver CNAs. Here, we extend a previously-presented supervised algorithm for the identification of CNAs that is based on a topological representation of the data. Our method associates a two-dimensional (2D) point cloud with each aCGH profile and generates a sequence of simplicial complexes, mathematical objects that generalize the concept of a graph. This representation of the data permits segmenting the data at different resolutions and identifying CNAs by interrogating the topological properties of these simplicial complexes. We tested our approach on a published dataset with the goal of identifying specific breast cancer CNAs associated with specific molecular subtypes. Identification of CNAs associated with each subtype was performed by analyzing each subtype separately from the others and by taking the rest of the subtypes as the control. Our results found a new amplification in 11q at the location of the progesterone receptor in the Luminal A subtype. Aberrations in the Luminal B subtype were found only upon removal of the basal-like subtype from the control set. Under those conditions, all regions found in the original publication, except for 17q, were confirmed; all aberrations, except those in chromosome arms 8q and 12q were confirmed in the basal-like subtype. These two chromosome arms, however, were detected only upon removal of three patients

  18. W-band integrated circuit PIN switches

    NASA Astrophysics Data System (ADS)

    Tahim, R. S.; Pham, T.; Chang, K.

    1986-12-01

    Both single-pole single-throw (SPST) and single-pole double-throw (SPDT) PIN switches have been developed at W band using microstrip integrated circuits. In SPST configurations, these switches have less than 1 dB of insertion loss under forward-voltage conditions from 90 to 108 GHz. Isolation greater than 20 dB over 3 GHz and greater than 10 dB over 7 GHz has been achieved. In SPDT configurations, insertion loss of less than 2 dB and isolation of more than 15 dB over 10 GHz (90 to 110 GHz) have been achieved. Beam-lead PIN diodes were used. Major features included mechanical ruggedness, light weight, small size and low-cost manufacturing.

  19. Tips Under the Skin: A Simple Modification of Extension Block Pinning for Mallet Fractures.

    PubMed

    Shin, Seung-Han; Lee, Yong-Suk; Kang, Jin-Woo; Kang, Wonwoo; Chung, Yang-Guk

    2018-03-01

    Pins exposed out of the skin after surgery for mallet fractures keep patients from washing their hands. The authors buried the tips of all pins under the skin while performing extension block pinning for 14 patients with mallet fractures. The patients were allowed to wash their hands 4 to 5 days postoperatively, without any dressing or splinting. The pins were removed at a mean of 8 weeks postoperatively. Solid union was achieved in all 14 fractures. No pull-out or subsidence of the pin was observed. No patient developed infection or other pin-related complications. Mean extension lag at final follow-up was 4°. [Orthopedics. 2018; 41(2):e299-e302.]. Copyright 2018, SLACK Incorporated.

  20. Flux pinning mechanism in codoped-MgB2 with Al2O3 and SiC

    NASA Astrophysics Data System (ADS)

    Kiafiroozkoohi, Narjess Sadat; Ghorbani, Shaban Reza; Arabi, Hadi

    2018-05-01

    MgB2 superconductor samples, co-doped with 0.02 wt of Al2O3 and 0.02 wt SiC, have been examined by M-H loop measurements and calculation of the critical current density based on the Bean model. Normalized volume pinning force, f = F/Fmax, as a function of the reduced magnetic field, h = H/Hmax has been obtained at each temperature. Hughochi flux pinning model, which was included the normal point pinning, the normal surface pinning, and the pinning based on spatial variation in the Ginzburg-Landau parameter, was used to study the flux pinning mechanisms. It was found that the Δκ effect and the normal point pinning mechanisms play the main role in the flux pinning at the magnetic field lower than Hmax and the contribution of the Δκ mechanism increases with the increasing temperature, while the contribution of normal point pinning mechanism decreases. At magnetic field larger than Hmax, the only mechanism that acts as the flux pinning was the normal surface pinning mechanism.

  1. The plasma membrane recycling pathway and cell polarity in plants: studies on PIN proteins.

    PubMed

    Boutté, Yohann; Crosnier, Marie-Thérèse; Carraro, Nicola; Traas, Jan; Satiat-Jeunemaitre, Béatrice

    2006-04-01

    The PIN-FORMED (PIN) proteins are plasma-membrane-associated facilitators of auxin transport. They are often targeted to one side of the cell only through subcellular mechanisms that remain largely unknown. Here, we have studied the potential roles of the cytoskeleton and endomembrane system in the localisation of PIN proteins. Immunocytochemistry and image analysis on root cells from Arabidopsis thaliana and maize showed that 10-30% of the intracellular PIN proteins mapped to the Golgi network, but never to prevacuolar compartments. The remaining 70-90% were associated with yet to be identified structures. The maintenance of PIN proteins at the plasma membrane depends on a BFA-sensitive machinery, but not on microtubules and actin filaments. The polar localisation of PIN proteins at the plasmamembrane was not reflected by any asymmetric distribution of cytoplasmic organelles. In addition, PIN proteins were inserted in a symmetrical manner at both sides of the cell plate during cytokinesis. Together, the data indicate that the localisation of PIN proteins is a postmitotic event, which depends on local characteristics of the plasma membrane and its direct environment. In this context, we present evidence that microtubule arrays might define essential positional information for PIN localisation. This information seems to require the presence of an intact cell wall.

  2. Calculation and analysis of shear resistance of segment ring joint with shear pin

    NASA Astrophysics Data System (ADS)

    Wu, Shengzhi; Huang, Haibin; Wang, Mingnian; Xiao, Shihui; Liu, Dagang

    2018-03-01

    In order to get the effect of shear pins between segments on the shear resistance of segment girth joints. Take the Maliuzhou traffic tunnel project of Zhuhai which with super large diameter and Marine Composite strata as the research object, the longitudinal shear stiffness of tunnel shear considering the shear rigidity of shear pins was obtained through the finite element shear experiment of segment ring. By comparing the calculation results of shear pin and non shear pin between segment ring connections, the conclusion that shear pin setting can effectively decompose and transfer shear force and control the dislocation between segment ring blocks is obtained. The study can be used as reference for the design and construction of shield tunnel.

  3. An Accelerated Method for Testing Soldering Tendency of Core Pins

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Han, Qingyou; Xu, Hanbing; Ried, Paul

    2010-01-01

    An accelerated method for testing die soldering has been developed. High intensity ultrasonic vibrations has been used to simulate the die casting conditions such as high pressure and high impingement speed of molten metal on the pin. Soldering tendency of steels and coated pins has been examined. The results indicate that in the low carbon steel/Al system, the onset of soldering is 60 times faster with ultrasonic vibration than that without ultrasonic vibration. In the H13/A380 system, the onset of soldering reaction is accelerated to 30-60 times. Coating significantly reduces the soldering tendency of the core pins.

  4. Pin and roller attachment system for ceramic blades

    DOEpatents

    Shaffer, James E.

    1995-01-01

    In a turbine, a plurality of blades are attached to a turbine wheel by way of a plurality of joints which form a rolling contact between the blades and the turbine wheel. Each joint includes a pin and a pair of rollers to provide rolling contact between the pin and an adjacent pair of blades. Because of this rolling contact, high stress scuffing between the blades and the turbine wheel reduced, thereby inhibiting catastrophic failure of the blade joints.

  5. Natural convection and radiation heat transfer from an array of inclined pin fins

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alessio, M.E.; Kaminski, D.A.

    1989-02-01

    Natural convection and radiation from an air-cooled, highly populated pin-fin array were studied experimentally. the effects of pin density, pin length, and the angle of the pin to the horizontal were measured. Previous work by Sparrow and Vemuri treated the case of a vertical base plate with horizontal fins. recently, Sparrow and Vemuri (1986) extended their study to include results for vertical fins with a horizontal down-facing base plate, as well as vertical fins with a horizontal up-facing base plate. In this study, the base plate is maintained in a vertical position and the angle of the pins is variedmore » from the horizontal. The main intent of this study was to compare the performance of inclined pin fins with straight pin fins. In all cases studied, the straight, horizontal fins were superior to the inclined fins. It was possible to obtain a single general correlation of the test data. While this correlation is recommended within the range of parameters that were tested here, one significant parameter, the size of the base plate, was not varied.« less

  6. Ultrasensitive Ambient Mass Spectrometric Analysis with a Pin-to-Capillary Flowing Atmospheric-Pressure Afterglow Source

    PubMed Central

    Shelley, Jacob T.; Wiley, Joshua S.; Hieftje, Gary M.

    2011-01-01

    The advent of ambient desorption/ionization mass spectrometry has resulted in a strong interest in ionization sources that are capable of direct analyte sampling and ionization. One source that has enjoyed increasing interest is the Flowing Atmospheric-Pressure Afterglow (FAPA). FAPA has been proven capable of directly desorbing/ionizing samples in any phase (solid, liquid, or gas) and with impressive limits of detection (<100 fmol). The FAPA was also shown to be less affected by competitive-ionization matrix effects than other plasma-based sources. However, the original FAPA design exhibited substantial background levels, cluttered background spectra in the negative-ion mode, and significant oxidation of aromatic analytes, which ultimately compromised analyte identification and quantification. In the present study, a change in the FAPA configuration from a pin-to-plate to a pin-to-capillary geometry was found to vastly improve performance. Background signals in positive- and negative-ionization modes were reduced by 89% and 99%, respectively. Additionally, the capillary anode strongly reduced the amount of atomic oxygen that could cause oxidation of analytes. Temperatures of the gas stream that interacts with the sample, which heavily influences desorption capabilities, were compared between the two sources by means of IR thermography. The performance of the new FAPA configuration is evaluated through the determination of a variety of compounds in positive- and negative-ion mode, including agrochemicals and explosives. A detection limit of 4 amol was found for the direct determination of the agrochemical ametryn, and appears to be spectrometer-limited. The ability to quickly screen for analytes in bulk liquid samples with the pin-to-capillary FAPA is also shown. PMID:21627097

  7. Ultrasensitive ambient mass spectrometric analysis with a pin-to-capillary flowing atmospheric-pressure afterglow source.

    PubMed

    Shelley, Jacob T; Wiley, Joshua S; Hieftje, Gary M

    2011-07-15

    The advent of ambient desorption/ionization mass spectrometry has resulted in a strong interest in ionization sources that are capable of direct analyte sampling and ionization. One source that has enjoyed increasing interest is the flowing atmospheric-pressure afterglow (FAPA). The FAPA has been proven capable of directly desorbing/ionizing samples in any phase (solid, liquid, or gas) and with impressive limits of detection (<100 fmol). The FAPA was also shown to be less affected by competitive-ionization matrix effects than other plasma-based sources. However, the original FAPA design exhibited substantial background levels, cluttered background spectra in the negative-ion mode, and significant oxidation of aromatic analytes, which ultimately compromised analyte identification and quantification. In the present study, a change in the FAPA configuration from a pin-to-plate to a pin-to-capillary geometry was found to vastly improve performance. Background signals in positive- and negative-ionization modes were reduced by 89% and 99%, respectively. Additionally, the capillary anode strongly reduced the amount of atomic oxygen that could cause oxidation of analytes. Temperatures of the gas stream that interacts with the sample, which heavily influences desorption capabilities, were compared between the two sources by means of IR thermography. The performance of the new FAPA configuration is evaluated through the determination of a variety of compounds in positive- and negative-ion mode, including agrochemicals and explosives. A detection limit of 4 amol was found for the direct determination of the agrochemical ametryn and appears to be spectrometer-limited. The ability to quickly screen for analytes in bulk liquid samples with the pin-to-capillary FAPA is also shown.

  8. A novel reconfigurable electromagnetically induced transparency based on S-PINs

    NASA Astrophysics Data System (ADS)

    Xue, Feng; Liu, Shao-Bin; Zhang, Hai-Feng; Wen, Yong-Diao; Kong, Xiang-Kun; Li, Hai-Ming

    2018-02-01

    In this paper, a tunable electromagnetically induced transparency (EIT) based on S-PINs is theoretically analyzed. Unit cell of the structure consists of a cutwire (CW), split ring resonator (SRR), and solid state plasma (SS plasma) patches which are composed of S-PIN array. The destructive interference between the CW and SRR results in a narrowband transparency window accompanied with strong phase dispersion. The proposed design can obtain a tunable EIT with different frequencies range from 12.8 GHz to 16.5 GHz in a simple method by switching these S-PINs on or off selectively. The related parameters of the S-PIN such as the size, carrier concentration, and volt-ampere characteristics have been studied theoretically. The interaction and coupling between two resonators are investigated in detail by the analysis of the current distribution and E-field strength as well. The research results provide an effective way to realize reconfigurable compact slow-light devices.

  9. Pin stripe lamination: A distinctive feature of modern and ancient eolian sediments

    USGS Publications Warehouse

    Fryberger, S.G.; Schenk, C.J.

    1988-01-01

    Pin stripe laminations are a distinctive feature of modern and ancient eolian sediments. In sets of eolian ripple (or translatent) strata they represent deposition of silt and very fine sand in the troughs of the advancing wind ripples. In sets of avalanche strata they probably result from the downward settling of fine sand and silt within the moving avalanche to the interface of moving and unmoving sands. Wind tunnel experiments suggest that pin stripe laminations can also form in grainfall deposits. The textural segregation associated with deposition of the fine layers in most cases leads to early cementation along and near the finest sand and silt comprising the pin stripe lamination. The pin stripe effect seen in outcrops is usually due to resistance to weathering along such cemented zones. The cementation of the pin stripe laminations can occur early in the history of diagenesis and thus may provide clues to the post-depositional history of the rock. Pin stripe laminations in many instances represent the sequestering of the small population of ultrafine sediment present in most eolian depositional systems. They may prove useful in the recognition of ancient eolian sediments. ?? 1988.

  10. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

    NASA Astrophysics Data System (ADS)

    Campaner, Elena; Rustighi, Alessandra; Zannini, Alessandro; Cristiani, Alberto; Piazza, Silvano; Ciani, Yari; Kalid, Ori; Golan, Gali; Baloglu, Erkan; Shacham, Sharon; Valsasina, Barbara; Cucchi, Ulisse; Pippione, Agnese Chiara; Lolli, Marco Lucio; Giabbai, Barbara; Storici, Paola; Carloni, Paolo; Rossetti, Giulia; Benvenuti, Federica; Bello, Ezia; D'Incalci, Maurizio; Cappuzzello, Elisa; Rosato, Antonio; Del Sal, Giannino

    2017-06-01

    The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly contributes to tumour initiation and progression. Inactivation of PIN1 function conversely curbs tumour growth and cancer stem cell expansion, restores chemosensitivity and blocks metastatic spread, thus providing the rationale for a therapeutic strategy based on PIN1 inhibition. Notwithstanding, potent PIN1 inhibitors are still missing from the arsenal of anti-cancer drugs. By a mechanism-based screening, we have identified a novel covalent PIN1 inhibitor, KPT-6566, able to selectively inhibit PIN1 and target it for degradation. We demonstrate that KPT-6566 covalently binds to the catalytic site of PIN1. This interaction results in the release of a quinone-mimicking drug that generates reactive oxygen species and DNA damage, inducing cell death specifically in cancer cells. Accordingly, KPT-6566 treatment impairs PIN1-dependent cancer phenotypes in vitro and growth of lung metastasis in vivo.

  11. A Water Droplet Pinning and Heat Transfer Characteristics on an Inclined Hydrophobic Surface.

    PubMed

    Al-Sharafi, Abdullah; Yilbas, Bekir Sami; Ali, Haider; AlAqeeli, N

    2018-02-15

    A water droplet pinning on inclined hydrophobic surface is considered and the droplet heat transfer characteristics are examined. Solution crystallization of polycarbonate is carried out to create hydrophobic characteristics on the surface. The pinning state of the water droplet on the extreme inclined hydrophobic surface (0° ≤ δ ≤ 180°, δ being the inclination angle) is assessed. Heat transfer from inclined hydrophobic surface to droplet is simulated for various droplet volumes and inclination angles in line with the experimental conditions. The findings revealed that the hydrophobic surface give rise to large amount of air being trapped within texture, which generates Magdeburg like forces between the droplet meniscus and the textured surface while contributing to droplet pinning at extreme inclination angles. Two counter rotating cells are developed for inclination angle in the range of 0° < δ < 20° and 135° < δ < 180°; however, a single circulation cell is formed inside the droplet for inclination angle of 25° ≤ δ ≤ 135°. The Nusselt number remains high for the range of inclination angle of 45° ≤ δ ≤ 135°. Convection and conduction heat transfer enhances when a single and large circulation cell is formed inside the droplet.

  12. Monte Carlo characterization of PWR spent fuel assemblies to determine the detectability of pin diversion

    NASA Astrophysics Data System (ADS)

    Burdo, James S.

    difference was less than 1.00, allowing for the existence of the difference within the margin of error. The second was whether the difference between the two values was big enough to prevent their error bars from overlapping. Error analysis was performed both using a one second count and pseudo-Maxwell statistics for a projected 60 second count, giving four criteria for detection. The number of guide tubes meeting these criteria was compared and graphed for each case. Further analysis at extremes of high and low enrichment and long and short burnup times was done using data from assemblies at the Beaver Valley 1 and 2 PWR. In all neutron flux cases, at least two guide tube locations meet all the criteria for detection of pin diversion. At least one location in almost all of the gamma flux cases does. These results show that placing detectors in the empty guide tubes of spent fuel bundles to identify possible pin diversion is feasible.

  13. A Sharp Lesson: Duodenal Perforation 2 Months after Ingestion of a Pin.

    PubMed

    Dalrymple, Rebecca Amy; Berry, Kathleen; Jester, Ingo

    2017-01-01

    An 11-year-old female child presented 2 months after accidentally swallowing her hijab pin, with right-sided abdominal pain. An X-ray showed that the pin was located in her right upper quadrant, and at laparoscopy, it was found to have eroded through her duodenum into her liver. Ingested pins should always be removed if not passed spontaneously within the first few days.

  14. A Sharp Lesson: Duodenal Perforation 2 Months after Ingestion of a Pin

    PubMed Central

    Dalrymple, Rebecca Amy; Berry, Kathleen; Jester, Ingo

    2017-01-01

    An 11-year-old female child presented 2 months after accidentally swallowing her hijab pin, with right-sided abdominal pain. An X-ray showed that the pin was located in her right upper quadrant, and at laparoscopy, it was found to have eroded through her duodenum into her liver. Ingested pins should always be removed if not passed spontaneously within the first few days. PMID:28694580

  15. Fermi-Level Pinning of Contacted Single-Wall Carbon Nanotubes

    NASA Astrophysics Data System (ADS)

    Wu, Shi-Yu; Liu, Lei; Jayanthi, Chakram; Guo, Guang-Yu

    2004-03-01

    Experimental evidences suggest that the Fermi-level of a contacted SWCNT with an energy gap is pinned in the vicinity of either the top of the valence band or the bottom of the conduction band, depending on the work function of the metallic leads (see, for example, E. D. Minot, Yuval Yaish,Vera Sazonova, Ji-Yong Park, Markus Brink, and Paul L. McEuen, Phys. Rev. Lett. 90, 156401 (2003)). This pinning of the Fermi-level may be attributed to the finite length of the contacted SWCNT. In this presentation, we report the result of our study of the pinning of the Fermi-level of a finite SWCNT, using the single π-orbital theory modified by the inclusion of a self-consistent scheme for the determination of charge transfer. We will also discuss the effect of the Fermi-level pinning on the transport properties of a SWCNT with a gap, either intrinsic or induced by a mechanical deformation. This work is supported by the NSF (Grant Nos: DMR-0112824 and ECS-0224114), the U.S. Department of Energy (Grant No: DE-FG02-00ER45832), and the National Science Council of Taiwan.

  16. Cryogenically cooled detector pin mount

    DOEpatents

    Hunt, Jr., William E; Chrisp, Michael P

    2014-06-03

    A focal plane assembly facilitates a molybdenum base plate being mounted to another plate made from aluminum. The molybdenum pin is an interference fit (press fit) in the aluminum base plate. An annular cut out area in the base plate forms two annular flexures.

  17. Pin and roller attachment system for ceramic blades

    DOEpatents

    Shaffer, J.E.

    1995-07-25

    In a turbine, a plurality of blades are attached to a turbine wheel by way of a plurality of joints which form a rolling contact between the blades and the turbine wheel. Each joint includes a pin and a pair of rollers to provide rolling contact between the pin and an adjacent pair of blades. Because of this rolling contact, high stress scuffing between the blades and the turbine wheel reduced, thereby inhibiting catastrophic failure of the blade joints. 3 figs.

  18. AtPIN2 defines a locus of Arabidopsis for root gravitropism control.

    PubMed Central

    Müller, A; Guan, C; Gälweiler, L; Tänzler, P; Huijser, P; Marchant, A; Parry, G; Bennett, M; Wisman, E; Palme, K

    1998-01-01

    The molecular mechanisms underlying gravity perception and signal transduction which control asymmetric plant growth responses are as yet unknown, but are likely to depend on the directional flux of the plant hormone auxin. We have isolated an Arabidopsis mutant of the AtPIN2 gene using transposon mutagenesis. Roots of the Atpin2::En701 null-mutant were agravitropic and showed altered auxin sensitivity, a phenotype characteristic of the agravitropic wav6-52 mutant. The AtPIN2 gene was mapped to chromosome 5 (115.3 cM) corresponding to the WAV6 locus and subsequent genetic analysis indicated that wav6-52 and Atpin2::En701 were allelic. The AtPIN2 gene consists of nine exons defining an open reading frame of 1944 bp which encodes a 69 kDa protein with 10 putative transmembrane domains interrupted by a central hydrophilic loop. The topology of AtPIN2p was found to be similar to members of the major facilitator superfamily of transport proteins. We have shown that the AtPIN2 gene was expressed in root tips. The AtPIN2 protein was localized in membranes of root cortical and epidermal cells in the meristematic and elongation zones revealing a polar localization. These results suggest that AtPIN2 plays an important role in control of gravitropism regulating the redistribution of auxin from the stele towards the elongation zone of roots. PMID:9843496

  19. Relation between resistivity and temperature in the presence of two magnetic flux pinning mechanisms

    NASA Astrophysics Data System (ADS)

    Hosseinzadeh, Mohammad; Ghorbani, Shaban Reza; Arabi, Hadi

    2018-05-01

    Moving of vortices in type II superconductors leads to energy dissipation, and therefore pinning of them is a significant problem. Determination of pinning potential and pinning mechanism from experimental data of resistivity is an attractive issue in the phenomenological study of superconductors. A new formalism is suggested to determination of two the δTc and δℓ pinning mechanisms from the resistivity as a function of temperature in type II superconductors.

  20. Measurement of contact angle in a clearance-fit pin-loaded hole

    NASA Technical Reports Server (NTRS)

    Prabhakaran, R.; Naik, R. A.

    1986-01-01

    A technique which measures load-contact variation in a clearance-fit, pin-loaded hole is presented in detail. A steel instrumented pin, which activates a make-or-break electrical circuit in the pin-hole contact region, was inserted into one aluminum and one polycarbonate specimen. The resulting load-contact variations are indicated schematically. The ability to accurately determine the arc of contact at any load was crucial to this measurement. It is noted that this simple experimental technique is applicable to both conducting and nonconducting materials.

  1. Graph Theory-Based Pinning Synchronization of Stochastic Complex Dynamical Networks.

    PubMed

    Li, Xiao-Jian; Yang, Guang-Hong

    2017-02-01

    This paper is concerned with the adaptive pinning synchronization problem of stochastic complex dynamical networks (CDNs). Based on algebraic graph theory and Lyapunov theory, pinning controller design conditions are derived, and the rigorous convergence analysis of synchronization errors in the probability sense is also conducted. Compared with the existing results, the topology structures of stochastic CDN are allowed to be unknown due to the use of graph theory. In particular, it is shown that the selection of nodes for pinning depends on the unknown lower bounds of coupling strengths. Finally, an example on a Chua's circuit network is given to validate the effectiveness of the theoretical results.

  2. InP-based millimeter-wave PIN diodes for switching and phase-shifting application

    NASA Astrophysics Data System (ADS)

    Pavlidis, Dimitris; Alekseev, Egor; Hong, Kyushik; Cui, Delong

    1997-10-01

    InP-based PIN design, technology and circuit implementation were addressed and successfully applied to millimeter-wave MMIC switches and phase shifters. A wet etchant based via technology was developed and applied to InP MMIC fabrication. MOCVD and MBE material growth was used for PIN realization and PIN specific growth optimization is discussed. Experimentally determined electrical characteristics and good performance is presented for a variety of InP-based PIN MMICs including coplanar and microstrip Ka-band SPST switches, W-band microstrip SPST switches and a 90-degree phase shifter.

  3. Simulations of vortices in a star-shaped plate with an artificial pin

    NASA Astrophysics Data System (ADS)

    Miyoshi, Hiroki; Ito, Atsuki; Dang, Vu The; Thanh Huy, Ho; Hayashi, Masahiko; Kato, Masaru; Ishida, Takekazu

    2017-07-01

    Although a triangular vortex lattice is stable in a bulk type-II superconductor, exotic vortex configurations are expected to appear in a small superconducting plate. Theoretical calculations on vortex structures in a star-shaped superconducting plate have been given in our preceding work. In this work, we extended our theoretical studies to the case of having an artificial pin. We performed the Ginzburg-Landau (GL) calculations systematically to compare with the pin-free case by using the finite element method. We found that a vortex tends to accommodate preferentially in an aritificial pin in the star-shaped plate. We found a systematic evolution of vortex structure with increaseing magnetic field. We compare our theoretical calculations with vortices in a star-shaped Mo80Ge20 plate with an artificial pin and without an artificial pin obtained by a scanning SQUID microscope. We reconstructed the vortex image on the sample surface by using the inverse Biot-Savart law and the Fourier transformation.

  4. Friction Stir Welding of Tapered Thickness Welds Using an Adjustable Pin Tool

    NASA Technical Reports Server (NTRS)

    Adams, Glynn; Venable, Richard; Lawless, Kirby

    2003-01-01

    Friction stir welding (FSW) can be used for joining weld lands that vary in thickness along the length of the weld. An adjustable pin tool mechanism can be used to accomplish this in a single-pass, full-penetration weld by providing for precise changes in the pin length relative to the shoulder face during the weld process. The difficulty with this approach is in accurately adjusting the pin length to provide a consistent penetration ligament throughout the weld. The weld technique, control system, and instrumentation must account for mechanical and thermal compliances of the tooling system to conduct tapered welds successfully. In this study, a combination of static and in-situ measurements, as well as active control, is used to locate the pin accurately and maintain the desired penetration ligament. Frictional forces at the pin/shoulder interface were a source of error that affected accurate pin position. A traditional FSW pin tool design that requires a lead angle was used to join butt weld configurations that included both constant thickness and tapered sections. The pitch axis of the tooling was fixed throughout the weld; therefore, the effective lead angle in the tapered sections was restricted to within the tolerances allowed by the pin tool design. The sensitivity of the FSW process to factors such as thickness offset, joint gap, centerline offset, and taper transition offset were also studied. The joint gap and the thickness offset demonstrated the most adverse affects on the weld quality. Two separate tooling configurations were used to conduct tapered thickness welds successfully. The weld configurations included sections in which the thickness decreased along the weld, as well as sections in which the thickness increased along the weld. The data presented here include weld metallography, strength data, and process load data.

  5. Strong pinning regimes explored with large-scale Ginzburg-Landau simulations

    NASA Astrophysics Data System (ADS)

    Willa, Roland; Koshelev, Alexei E.

    Improving the current-carrying capability of superconductors requires a deep understanding of vortex pinning. Within the theory of (3D) strong pinning an ideal vortex lattice is weakly deformed by a low density np of strong defects. In this limit the critical current jc is expected to grow linearly with np and to decrease with the field B according to B-α with α 0 . 5 . In the small-field limit the (1D) strong pinning theory of isolated vortices predicts jc np0 . 5 , independent of B. We explore strong pinning by low defect densities using time-dependent Ginzburg-Landau simulations. Our numerical results suggest the existence of a wide regime, where the lattice order is destroyed and yet interactions between vortices are important. In particular, for large defects we found an extended range of power-law decay of jc (B) with α 0 . 3 , smaller than predicted. This regime requires the development of new analytical models. Exploring the behavior of jc for various defect densities and sizes, we will establish pinning regimes and applicability limits of the conventional theory. This work is supported by the U.S. Department of Energy, Office of Science, Materials Sciences and Engineering Division. R. W. acknowledges support from the Swiss National Science Foundation through the SNSF Early Postdoc Mobility Fellowship.

  6. Environment-based pin-power reconstruction method for homogeneous core calculations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leroyer, H.; Brosselard, C.; Girardi, E.

    2012-07-01

    Core calculation schemes are usually based on a classical two-step approach associated with assembly and core calculations. During the first step, infinite lattice assemblies calculations relying on a fundamental mode approach are used to generate cross-sections libraries for PWRs core calculations. This fundamental mode hypothesis may be questioned when dealing with loading patterns involving several types of assemblies (UOX, MOX), burnable poisons, control rods and burn-up gradients. This paper proposes a calculation method able to take into account the heterogeneous environment of the assemblies when using homogeneous core calculations and an appropriate pin-power reconstruction. This methodology is applied to MOXmore » assemblies, computed within an environment of UOX assemblies. The new environment-based pin-power reconstruction is then used on various clusters of 3x3 assemblies showing burn-up gradients and UOX/MOX interfaces, and compared to reference calculations performed with APOLLO-2. The results show that UOX/MOX interfaces are much better calculated with the environment-based calculation scheme when compared to the usual pin-power reconstruction method. The power peak is always better located and calculated with the environment-based pin-power reconstruction method on every cluster configuration studied. This study shows that taking into account the environment in transport calculations can significantly improve the pin-power reconstruction so far as it is consistent with the core loading pattern. (authors)« less

  7. Monolithically Integrated SiGe/Si PIN-HBT Front-End Transimpedance Photoreceivers

    NASA Technical Reports Server (NTRS)

    Rieh, J.-S.; Qasaimeh, O.; Klotzkin, D.; Lu, L.-H.; Katehi, L. P. B.; Yang, K.; Bhattacharya, P.; Croke, E. T.

    1997-01-01

    The demand for monolithically integrated photoreceivers based on Si-based technology keeps increasing as low cost and high reliability products are required for the expanding commercial market. Higher speed and wider operating frequency range are expected when SiGe/Si heterojunction is introduced to the circuit design. In this paper, a monolithic SiGe/Si PIN-HBT front-end transimpedance photoreceiver is demonstrated for the first time. For this purpose, mesa-type SiGe/Si PIN-HBT technology was developed. Fabricated HBTs exhibit f(sub max) of 34 GHz with DC gain of 25. SiGe/Si PIN photodiodes, which share base and collector layers of HBTs, demonstrate responsivity of 0.3 A/W at lambda=850 nm and bandwidth of 450 MHz. Based on these devices, single- and dual-feedback transimpedance amplifiers were fabricated and they exhibited the bandwidth of 3.2 GHz and 3.3 GHz with the transimpedance gain of 45.2 dB(Omega) and 47.4 dB(Omega) respectively. Monolithically integrated single-feedback PIN-HBT photoreceivers were implemented and the bandwidth was measured to be approx. 0.5 GHz, which is limited by the bandwidth of PIN photodiodes.

  8. Identification of Nonlinear Micron-Level Mechanics for a Precision Deployable Joint

    NASA Technical Reports Server (NTRS)

    Bullock, S. J.; Peterson, L. D.

    1994-01-01

    The experimental identification of micron-level nonlinear joint mechanics and dynamics for a pin-clevis joint used in a precision, adaptive, deployable space structure are investigated. The force-state mapping method is used to identify the behavior of the joint under a preload. The results of applying a single tension-compression cycle to the joint under a tensile preload are presented. The observed micron-level behavior is highly nonlinear and involves all six rigid body motion degrees-of-freedom of the joint. it is also suggests that at micron levels of motion modelling of the joint mechanics and dynamics must include the interactions between all internal components, such as the pin, bushings, and the joint node.

  9. Analysis, inspection, and repair methods for pin connections on Illinois bridges

    DOT National Transportation Integrated Search

    1992-04-01

    This report documents methods used in Illinois for analysis, inspection, and repair of pin connections in bridges. Weldable foil strain gages were used to detect the effects of unknown levels of fixity in pins on cantilever truss bridges. Other metho...

  10. Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.

    PubMed

    Lian, Xiaolan; Lin, Yu-Min; Kozono, Shingo; Herbert, Megan K; Li, Xin; Yuan, Xiaohong; Guo, Jiangrui; Guo, Yafei; Tang, Min; Lin, Jia; Huang, Yiping; Wang, Bixin; Qiu, Chenxi; Tsai, Cheng-Yu; Xie, Jane; Cao, Ziang Jeff; Wu, Yong; Liu, Hekun; Zhou, Xiaozhen; Lu, Kunping; Chen, Yuanzhong

    2018-05-30

    The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with the ability to block multiple cancer-driving pathways is thus imperative. The unique peptidyl-prolyl cis-trans isomerase Pin1 has been reported to promote tumorigenesis through upregulation of numerous cancer-driving pathways. Although Pin1 is a key drug target for treating acute promyelocytic leukemia (APL) caused by a fusion oncogene, much less is known about the role of Pin1 in other heterogeneous leukemia. The mRNA and protein levels of Pin1 were detected in samples from de novo leukemia patients and healthy controls using real-time quantitative RT-PCR (qRT-PCR) and western blot. The establishment of the lentiviral stable-expressed short hairpin RNA (shRNA) system and the tetracycline-inducible shRNA system for targeting Pin1 were used to analyze the biological function of Pin1 in AML cells. The expression of cancer-related Pin1 downstream oncoproteins in shPin1 (Pin1 knockdown) and Pin1 inhibitor all-trans retinoic acid (ATRA) treated leukemia cells were examined by western blot, followed by evaluating the effects of genetic and chemical inhibition of Pin1 in leukemia cells on transformed phenotype, including cell proliferation and colony formation ability, using trypan blue, cell counting assay, and colony formation assay in vitro, as well as the tumorigenesis ability using in vivo xenograft mouse models. First, we found that the expression of Pin1 mRNA and protein was significantly increased in both de novo leukemia clinical samples and multiple leukemia cell lines, compared with healthy controls. Furthermore, genetic or chemical inhibition of Pin1 in human multiple leukemia cell lines potently inhibited multiple Pin1 substrate oncoproteins and effectively suppressed leukemia cell proliferation and colony formation ability in cell culture models in vitro. Moreover

  11. PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression.

    PubMed

    Li, Na; Yuan, Kai; Yan, Feng; Huo, Yuda; Zhu, Tongge; Liu, Xing; Guo, Zhen; Yao, Xuebiao

    2009-06-19

    Mitotic chromosome movements are orchestrated by interactions between spindle microtubules and chromosomes. It is well known that kinetochore is the major site where microtubule-chromosome attachment occurs. However, the functions of other domains of chromosome such as chromosome periphery have remained elusive. Our previous studies show that PinX1 distributes to chromosome periphery and kinetochore during mitosis, and harbors the microtubule binding activity. Here we report that PinX1 interacts with Nucleolin, a chromosome periphery protein, through its C-termini. Deconvolution microscopic analyses show PinX1 mainly co-localizes with Nucleolin at chromosome periphery in prometaphase. Moreover, depletion of Nucleolin abolishes chromosome periphery localizations of PinX1, suggesting a functional interrelationship between PinX1 and Nucleolin. Importantly, repression of PinX1 and Nucleolin abrogates chromosome segregation in real-time mitosis, validating the functional importance of PinX1-Nucleolin interaction. We propose PinX1 is recruited to chromosome periphery by Nucleolin and a complex of PinX1 and Nucleolin is essential for faithful chromosome congression.

  12. The "safe zone" in medial percutaneous calcaneal pin placement.

    PubMed

    Gamie, Zakareya; Donnelly, Leo; Tsiridis, Eleftherios

    2009-05-01

    Percutaneous pin insertion into the medial calcaneus places a number of structures at risk. Evidence suggests that the greatest risk is to the medial calcaneal nerve (MCN). The medial calcaneal region of 24 cadavers was dissected to determine the major structures at risk. By using four palpable anatomical landmarks, the inferior tip of the medial malleolus (point A), the posterior superior portion of the calcaneal tuberosity (point B), the navicular tuberosity (point C), and the medial process of the calcaneal tuberosity (point D), we attempted to define the safe zone taking into account all possible variables in our dissections including ankle position, side, gender, and possible anatomical variations of the MCN. The commonest arrangement of the MCN was two MCNs that arose independently, one arising before the bifurcation of the tibial nerve and the other arising from the medial plantar nerve. A zone could be defined posterior to 75% of the distance along the lines AB, CD, AD, and CB which would avoid most structures. The posterior branches of the MCN, however, would still be at risk and placing the pin too far posteriorly risks an avulsion fracture. This is the first study to employ four palpable anatomical landmarks to identify a zone to minimize damage to neurovascular structures. It may not be possible, however, to avoid injury of the MCN and consequent sensory loss to the sole of the foot.

  13. Propagation of spiral waves pinned to circular and rectangular obstacles.

    PubMed

    Sutthiopad, Malee; Luengviriya, Jiraporn; Porjai, Porramain; Phantu, Metinee; Kanchanawarin, Jarin; Müller, Stefan C; Luengviriya, Chaiya

    2015-05-01

    We present an investigation of spiral waves pinned to circular and rectangular obstacles with different circumferences in both thin layers of the Belousov-Zhabotinsky reaction and numerical simulations with the Oregonator model. For circular objects, the area always increases with the circumference. In contrast, we varied the circumference of rectangles with equal areas by adjusting their width w and height h. For both obstacle forms, the propagating parameters (i.e., wavelength, wave period, and velocity of pinned spiral waves) increase with the circumference, regardless of the obstacle area. Despite these common features of the parameters, the forms of pinned spiral waves depend on the obstacle shapes. The structures of spiral waves pinned to circles as well as rectangles with the ratio w/h∼1 are similar to Archimedean spirals. When w/h increases, deformations of the spiral shapes are observed. For extremely thin rectangles with w/h≫1, these shapes can be constructed by employing semicircles with different radii which relate to the obstacle width and the core diameter of free spirals.

  14. Greater number of group identifications is associated with healthier behaviour: Evidence from a Scottish community sample.

    PubMed

    Sani, Fabio; Madhok, Vishnu; Norbury, Michael; Dugard, Pat; Wakefield, Juliet R H

    2015-09-01

    This paper investigates the interplay between group identification (i.e., the extent to which one has a sense of belonging to a social group, coupled with a sense of commonality with in-group members) and four types of health behaviour, namely physical exercise, smoking, drinking, and diet. Specifically, we propose a positive relationship between one's number of group identifications and healthy behaviour. This study is based on the Scottish portion of the data obtained for Wave 1 of the two-wave cross-national Health in Groups project. Totally 1,824 patients from five Scottish general practitioner (GP) surgeries completed the Wave 1 questionnaire in their homes. Participants completed measures of group identification, group contact, health behaviours, and demographic variables. Results demonstrate that the greater the number of social groups with which one identifies, the healthier one's behaviour on any of the four health dimensions considered. We believe our results are due to the fact that group identification will generally (1) enhance one's sense of meaning in life, thereby leading one to take more care of oneself, (2) increase one's sense of responsibility towards other in-group members, thereby enhancing one's motivation to be healthy in order to fulfil those responsibilities, and (3) increase compliance with healthy group behavioural norms. Taken together, these processes amply overcompensate for the fact that some groups with which people may identify can actually prescribe unhealthy behaviours. © 2014 The British Psychological Society.

  15. Generation of plate tectonics with two-phase grain-damage and pinning: Source-sink model and toroidal flow

    NASA Astrophysics Data System (ADS)

    Bercovici, David; Ricard, Yanick

    2013-03-01

    The grain-damage and pinning mechanism of Bercovici and Ricard (2012) for lithospheric shear-localization is employed in two-dimensional flow calculations to test its ability to generate toroidal (strike-slip) motion and influence plate evolution. This mechanism posits that damage to the interface between phases in a polycrystalline material like peridotite (composed primarily of olivine and pyroxene) increases the number of small Zener pinning surfaces, which then constrain mineral grains to ever smaller sizes, regardless of creep mechanism. This effect allows a self-softening feedback in which damage and grain-reduction can co-exist with a grain-size dependent diffusion creep rheology; moreover, grain growth and weak-zone healing are greatly impeded by Zener pinning thereby leading to long-lived relic weak zones. The fluid dynamical calculations employ source-sink driven flow as a proxy for convective poloidal flow (upwelling/downwelling and divergent/convergent motion), and the coupling of this flow with non-linear rheological mechanisms excites toroidal or strike-slip motion. The numerical experiments show that pure dislocation-creep rheology, and grain-damage without Zener pinning (as occurs in a single-phase assemblages) permit only weak localization and toroidal flow; however, the full grain-damage with pinning readily allows focussed localization and intense, plate-like toroidal motion and strike-slip deformation. Rapid plate motion changes are also tested with abrupt rotations of the source-sink field after a plate-like configuration is developed; the post-rotation flow and material property fields retain memory of the original configuration for extensive periods, leading to suboptimally aligned plate boundaries (e.g., strike-slip margins non-parallel to plate motion), oblique subduction, and highly localized, weak and long lived acute plate-boundary junctions such as at what is observed at the Aleutian-Kurile intersection. The grain-damage and pinning

  16. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development.

    PubMed

    Pu, Wenchen; Li, Jiao; Zheng, Yuanyuan; Shen, Xianyan; Fan, Xin; Zhou, Jian-Kang; He, Juan; Deng, Yulan; Liu, Xuesha; Wang, Chun; Yang, Shengyong; Chen, Qiang; Liu, Lunxu; Zhang, Guolin; Wei, Yu-Quan; Peng, Yong

    2018-01-30

    Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, but there are few effective treatments. Aberrant microRNA (miRNA) biogenesis is correlated with HCC development. We previously demonstrated that peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) participates in miRNA biogenesis and is a potential HCC treatment target. However, how Pin1 modulates miRNA biogenesis remains obscure. Here, we present in vivo evidence that Pin1 overexpression is directly linked to the development of HCC. Administration with the Pin1 inhibitor (API-1), a specific small molecule targeting Pin1 peptidyl-prolyl isomerase domain and inhibiting Pin1 cis-trans isomerizing activity, suppresses in vitro cell proliferation and migration of HCC cells. But API-1-induced Pin1 inhibition is insensitive to HCC cells with low Pin1 expression and/or low exportin-5 (XPO5) phosphorylation. Mechanistically, Pin1 recognizes and isomerizes the phosphorylated serine-proline motif of phosphorylated XPO5 and passivates phosphorylated XPO5. Pin1 inhibition by API-1 maintains the active conformation of phosphorylated XPO5 and restores XPO5-driven precursor miRNA nuclear-to-cytoplasm export, activating anticancer miRNA biogenesis and leading to both in vitro HCC suppression and HCC suppression in xenograft mice. Experimental evidence suggests that Pin1 inhibition by API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development, revealing the mechanism of Pin1-mediated miRNA biogenesis and unequivocally supporting API-1 as a drug candidate for HCC therapy, especially for Pin1-overexpressing, extracellular signal-regulated kinase-activated HCC. (Hepatology 2018). © 2018 by the American Association for the Study of Liver Diseases.

  17. Seal assembly with anti-rotation pin for high pressure supercritical fluids

    DOEpatents

    Wright, Steven A.; Fuller, Robert L.

    2014-08-05

    A seal assembly for sealing a machine with a first chamber and a second chamber is provided. A rotating shaft extends through the first and second chambers, and rotates therein. The seal assembly has a seal housing, a seal ring and a seal pin. The seal housing is positionable in the machine housing. The seal housing has a seal pocket extending into a fluid side thereof, and a housing receptacle extending into an inner diameter thereof at the seal pocket. The seal ring is positionable in the seal pocket of the seal housing for forming a seal therewith. The seal ring has a ring receptacle extending into an outer diameter thereof. The ring receptacle is positionable adjacent to the housing receptacle for defining a pin hole therebetween. The seal pin is loosely positionable in the pin hole whereby movement about the seal ring is accommodated while preventing rotation thereof.

  18. Sputtered pin amorphous silicon semi-conductor device and method therefor

    DOEpatents

    Moustakas, Theodore D.; Friedman, Robert A.

    1983-11-22

    A high efficiency amorphous silicon PIN semi-conductor device is constructed by the sequential sputtering of N, I and P layers of amorphous silicon and at least one semi-transparent ohmic electrode. A method of construction produces a PIN device, exhibiting enhanced physical integrity and facilitates ease of construction in a singular vacuum system and vacuum pump down procedure.

  19. Effect of Pin Geometry on the Mechanical Strength of Friction-Stir-Welded Polypropylene Composite Plates

    NASA Astrophysics Data System (ADS)

    Kordestani, F.; Ashenai Ghasemi, F.; Arab, N. B. M.

    2017-09-01

    Friction stir welding (FSW) is a solid-state welding process, which has successfully been applied in aerospace and automotive industries for joining materials. The friction stir tool is the key element in the FSW process. In this study, the effect of four different tool pin geometries on the mechanical properties of two types of polypropylene composite plates, with 30% glass and carbon fiber, respectively, were investigated. For this purpose, four pins of different geometry, namely, a threaded-tapered pin, square pin, four-flute threaded pin, and threaded-tapered pin with a chamfer were made and used to carry out the butt welding of 5-mm-thick plates. The standard tensile and Izod impact tests were performed to evaluate the tensile strength and impact toughness of welded specimens. The results indicated that the threaded-tapered pin with a chamfer produced welds with a better surface appearance and higher tensile and impact strengths. The tests also showed that, with the threaded-tapered pin with a chamfer, the impact strength of the glass- and carbon-fiber composite welds were about 40 and 50%, respectively, of that of the base materials.

  20. Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α

    PubMed Central

    Han, Hyeong-jun; Kwon, Nayoung; Choi, Min-A; Jung, Kyung Oh; Piao, Juan-Yu; Ngo, Hoang Kieu Chi; Kim, Su-Jung; Kim, Do-Hee; Chung, June-Key; Cha, Young-Nam; Youn, Hyewon; Choi, Bu Young; Min, Sang-Hyun; Surh, Young-Joon

    2016-01-01

    Peptidyl prolyl isomerase (PIN1) regulates the functional activity of a subset of phosphoproteins through binding to phosphorylated Ser/Thr-Pro motifs and subsequently isomerization of the phosphorylated bonds. Interestingly, PIN1 is overexpressed in many types of malignancies including breast, prostate, lung and colon cancers. However, its oncogenic functions have not been fully elucidated. Here, we report that PIN1 directly interacts with hypoxia-inducible factor (HIF)-1α in human colon cancer (HCT116) cells. PIN1 binding to HIF-1α occurred in a phosphorylation-dependent manner. We also found that PIN1 interacted with HIF-1α at both exogenous and endogenous levels. Notably, PIN1 binding stabilized the HIF-1α protein, given that their levels were significantly increased under hypoxic conditions. The stabilization of HIF-1α resulted in increased transcriptional activity, consequently upregulating expression of vascular endothelial growth factor, a major contributor to angiogenesis. Silencing of PIN1 or pharmacologic inhibition of its activity abrogated the angiogenesis. By utilizing a bioluminescence imaging technique, we were able to demonstrate that PIN1 inhibition dramatically reduced the tumor volume in a subcutaneous mouse xenograft model and angiogenesis as well as hypoxia-induced transcriptional activity of HIF-1α. These results suggest that PIN1 interacting with HIF-1α is a potential cancer chemopreventive and therapeutic target. PMID:26784107