Sample records for identifies small-world topology

  1. Suppression of anomalous synchronization and nonstationary behavior of neural network under small-world topology

    NASA Astrophysics Data System (ADS)

    Boaretto, B. R. R.; Budzinski, R. C.; Prado, T. L.; Kurths, J.; Lopes, S. R.

    2018-05-01

    It is known that neural networks under small-world topology can present anomalous synchronization and nonstationary behavior for weak coupling regimes. Here, we propose methods to suppress the anomalous synchronization and also to diminish the nonstationary behavior occurring in weakly coupled neural network under small-world topology. We consider a network of 2000 thermally sensitive identical neurons, based on the model of Hodgkin-Huxley in a small-world topology, with the probability of adding non local connection equal to p = 0 . 001. Based on experimental protocols to suppress anomalous synchronization, as well as nonstationary behavior of the neural network dynamics, we make use of (i) external stimulus (pulsed current); (ii) biologic parameters changing (neuron membrane conductance changes); and (iii) body temperature changes. Quantification analysis to evaluate phase synchronization makes use of the Kuramoto's order parameter, while recurrence quantification analysis, particularly the determinism, computed over the easily accessible mean field of network, the local field potential (LFP), is used to evaluate nonstationary states. We show that the methods proposed can control the anomalous synchronization and nonstationarity occurring for weak coupling parameter without any effect on the individual neuron dynamics, neither in the expected asymptotic synchronized states occurring for large values of the coupling parameter.

  2. A fault-tolerant small world topology control model in ad hoc networks for search and rescue

    NASA Astrophysics Data System (ADS)

    Tan, Mian; Fang, Ling; Wu, Yue; Zhang, Bo; Chang, Bowen; Holme, Petter; Zhao, Jing

    2018-02-01

    Due to their self-organized, multi-hop and distributed characteristics, ad hoc networks are useful in search and rescue. Topology control models need to be designed for energy-efficient, robust and fast communication in ad hoc networks. This paper proposes a topology control model which specializes for search and rescue-Compensation Small World-Repeated Game (CSWRG)-which integrates mobility models, constructing small world networks and a game-theoretic approach to the allocation of resources. Simulation results show that our mobility models can enhance the communication performance of the constructed small-world networks. Our strategy, based on repeated game, can suppress selfish behavior and compensate agents that encounter selfish or faulty neighbors. This model could be useful for the design of ad hoc communication networks.

  3. Collective relaxation dynamics of small-world networks

    NASA Astrophysics Data System (ADS)

    Grabow, Carsten; Grosskinsky, Stefan; Kurths, Jürgen; Timme, Marc

    2015-05-01

    Complex networks exhibit a wide range of collective dynamic phenomena, including synchronization, diffusion, relaxation, and coordination processes. Their asymptotic dynamics is generically characterized by the local Jacobian, graph Laplacian, or a similar linear operator. The structure of networks with regular, small-world, and random connectivities are reasonably well understood, but their collective dynamical properties remain largely unknown. Here we present a two-stage mean-field theory to derive analytic expressions for network spectra. A single formula covers the spectrum from regular via small-world to strongly randomized topologies in Watts-Strogatz networks, explaining the simultaneous dependencies on network size N , average degree k , and topological randomness q . We present simplified analytic predictions for the second-largest and smallest eigenvalue, and numerical checks confirm our theoretical predictions for zero, small, and moderate topological randomness q , including the entire small-world regime. For large q of the order of one, we apply standard random matrix theory, thereby overarching the full range from regular to randomized network topologies. These results may contribute to our analytic and mechanistic understanding of collective relaxation phenomena of network dynamical systems.

  4. Collective relaxation dynamics of small-world networks.

    PubMed

    Grabow, Carsten; Grosskinsky, Stefan; Kurths, Jürgen; Timme, Marc

    2015-05-01

    Complex networks exhibit a wide range of collective dynamic phenomena, including synchronization, diffusion, relaxation, and coordination processes. Their asymptotic dynamics is generically characterized by the local Jacobian, graph Laplacian, or a similar linear operator. The structure of networks with regular, small-world, and random connectivities are reasonably well understood, but their collective dynamical properties remain largely unknown. Here we present a two-stage mean-field theory to derive analytic expressions for network spectra. A single formula covers the spectrum from regular via small-world to strongly randomized topologies in Watts-Strogatz networks, explaining the simultaneous dependencies on network size N, average degree k, and topological randomness q. We present simplified analytic predictions for the second-largest and smallest eigenvalue, and numerical checks confirm our theoretical predictions for zero, small, and moderate topological randomness q, including the entire small-world regime. For large q of the order of one, we apply standard random matrix theory, thereby overarching the full range from regular to randomized network topologies. These results may contribute to our analytic and mechanistic understanding of collective relaxation phenomena of network dynamical systems.

  5. From brain to earth and climate systems: small-world interaction networks or not?

    PubMed

    Bialonski, Stephan; Horstmann, Marie-Therese; Lehnertz, Klaus

    2010-03-01

    We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With numerical simulations that mimic typical experimental situations, we have identified an important constraint when characterizing such networks: indications of a small-world topology can be expected solely due to the spatial sampling of the system along with the commonly used time series analysis based approaches to network characterization.

  6. Small-World Network Spectra in Mean-Field Theory

    NASA Astrophysics Data System (ADS)

    Grabow, Carsten; Grosskinsky, Stefan; Timme, Marc

    2012-05-01

    Collective dynamics on small-world networks emerge in a broad range of systems with their spectra characterizing fundamental asymptotic features. Here we derive analytic mean-field predictions for the spectra of small-world models that systematically interpolate between regular and random topologies by varying their randomness. These theoretical predictions agree well with the actual spectra (obtained by numerical diagonalization) for undirected and directed networks and from fully regular to strongly random topologies. These results may provide analytical insights to empirically found features of dynamics on small-world networks from various research fields, including biology, physics, engineering, and social science.

  7. Small-World Brain Networks Revisited

    PubMed Central

    Bassett, Danielle S.; Bullmore, Edward T.

    2016-01-01

    It is nearly 20 years since the concept of a small-world network was first quantitatively defined, by a combination of high clustering and short path length; and about 10 years since this metric of complex network topology began to be widely applied to analysis of neuroimaging and other neuroscience data as part of the rapid growth of the new field of connectomics. Here, we review briefly the foundational concepts of graph theoretical estimation and generation of small-world networks. We take stock of some of the key developments in the field in the past decade and we consider in some detail the implications of recent studies using high-resolution tract-tracing methods to map the anatomical networks of the macaque and the mouse. In doing so, we draw attention to the important methodological distinction between topological analysis of binary or unweighted graphs, which have provided a popular but simple approach to brain network analysis in the past, and the topology of weighted graphs, which retain more biologically relevant information and are more appropriate to the increasingly sophisticated data on brain connectivity emerging from contemporary tract-tracing and other imaging studies. We conclude by highlighting some possible future trends in the further development of weighted small-worldness as part of a deeper and broader understanding of the topology and the functional value of the strong and weak links between areas of mammalian cortex. PMID:27655008

  8. Harmony in the small-world

    NASA Astrophysics Data System (ADS)

    Marchiori, Massimo; Latora, Vito

    2000-10-01

    The small-world phenomenon, popularly known as six degrees of separation, has been mathematically formalized by Watts and Strogatz in a study of the topological properties of a network. Small-world networks are defined in terms of two quantities: they have a high clustering coefficient C like regular lattices and a short characteristic path length L typical of random networks. Physical distances are of fundamental importance in applications to real cases; nevertheless, this basic ingredient is missing in the original formulation. Here, we introduce a new concept, the connectivity length D, that gives harmony to the whole theory. D can be evaluated on a global and on a local scale and plays in turn the role of L and 1/ C. Moreover, it can be computed for any metrical network and not only for the topological cases. D has a precise meaning in terms of information propagation and describes in a unified way, both the structural and the dynamical aspects of a network: small-worlds are defined by a small global and local D, i.e., by a high efficiency in propagating information both on a local and global scale. The neural system of the nematode C. elegans, the collaboration graph of film actors, and the oldest US subway system, can now be studied also as metrical networks and are shown to be small-worlds.

  9. Temporal efficiency evaluation and small-worldness characterization in temporal networks

    PubMed Central

    Dai, Zhongxiang; Chen, Yu; Li, Junhua; Fam, Johnson; Bezerianos, Anastasios; Sun, Yu

    2016-01-01

    Numerous real-world systems can be modeled as networks. To date, most network studies have been conducted assuming stationary network characteristics. Many systems, however, undergo topological changes over time. Temporal networks, which incorporate time into conventional network models, are therefore more accurate representations of such dynamic systems. Here, we introduce a novel generalized analytical framework for temporal networks, which enables 1) robust evaluation of the efficiency of temporal information exchange using two new network metrics and 2) quantitative inspection of the temporal small-worldness. Specifically, we define new robust temporal network efficiency measures by incorporating the time dependency of temporal distance. We propose a temporal regular network model, and based on this plus the redefined temporal efficiency metrics and widely used temporal random network models, we introduce a quantitative approach for identifying temporal small-world architectures (featuring high temporal network efficiency both globally and locally). In addition, within this framework, we can uncover network-specific dynamic structures. Applications to brain networks, international trade networks, and social networks reveal prominent temporal small-world properties with distinct dynamic network structures. We believe that the framework can provide further insight into dynamic changes in the network topology of various real-world systems and significantly promote research on temporal networks. PMID:27682314

  10. Temporal efficiency evaluation and small-worldness characterization in temporal networks

    NASA Astrophysics Data System (ADS)

    Dai, Zhongxiang; Chen, Yu; Li, Junhua; Fam, Johnson; Bezerianos, Anastasios; Sun, Yu

    2016-09-01

    Numerous real-world systems can be modeled as networks. To date, most network studies have been conducted assuming stationary network characteristics. Many systems, however, undergo topological changes over time. Temporal networks, which incorporate time into conventional network models, are therefore more accurate representations of such dynamic systems. Here, we introduce a novel generalized analytical framework for temporal networks, which enables 1) robust evaluation of the efficiency of temporal information exchange using two new network metrics and 2) quantitative inspection of the temporal small-worldness. Specifically, we define new robust temporal network efficiency measures by incorporating the time dependency of temporal distance. We propose a temporal regular network model, and based on this plus the redefined temporal efficiency metrics and widely used temporal random network models, we introduce a quantitative approach for identifying temporal small-world architectures (featuring high temporal network efficiency both globally and locally). In addition, within this framework, we can uncover network-specific dynamic structures. Applications to brain networks, international trade networks, and social networks reveal prominent temporal small-world properties with distinct dynamic network structures. We believe that the framework can provide further insight into dynamic changes in the network topology of various real-world systems and significantly promote research on temporal networks.

  11. Trade-offs between robustness and small-world effect in complex networks

    PubMed Central

    Peng, Guan-Sheng; Tan, Suo-Yi; Wu, Jun; Holme, Petter

    2016-01-01

    Robustness and small-world effect are two crucial structural features of complex networks and have attracted increasing attention. However, little is known about the relation between them. Here we demonstrate that, there is a conflicting relation between robustness and small-world effect for a given degree sequence. We suggest that the robustness-oriented optimization will weaken the small-world effect and vice versa. Then, we propose a multi-objective trade-off optimization model and develop a heuristic algorithm to obtain the optimal trade-off topology for robustness and small-world effect. We show that the optimal network topology exhibits a pronounced core-periphery structure and investigate the structural properties of the optimized networks in detail. PMID:27853301

  12. The Conundrum of Functional Brain Networks: Small-World Efficiency or Fractal Modularity

    PubMed Central

    Gallos, Lazaros K.; Sigman, Mariano; Makse, Hernán A.

    2012-01-01

    The human brain has been studied at multiple scales, from neurons, circuits, areas with well-defined anatomical and functional boundaries, to large-scale functional networks which mediate coherent cognition. In a recent work, we addressed the problem of the hierarchical organization in the brain through network analysis. Our analysis identified functional brain modules of fractal structure that were inter-connected in a small-world topology. Here, we provide more details on the use of network science tools to elaborate on this behavior. We indicate the importance of using percolation theory to highlight the modular character of the functional brain network. These modules present a fractal, self-similar topology, identified through fractal network methods. When we lower the threshold of correlations to include weaker ties, the network as a whole assumes a small-world character. These weak ties are organized precisely as predicted by theory maximizing information transfer with minimal wiring costs. PMID:22586406

  13. Traumatic brain injury impairs small-world topology

    PubMed Central

    Pandit, Anand S.; Expert, Paul; Lambiotte, Renaud; Bonnelle, Valerie; Leech, Robert; Turkheimer, Federico E.

    2013-01-01

    Objective: We test the hypothesis that brain networks associated with cognitive function shift away from a “small-world” organization following traumatic brain injury (TBI). Methods: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging. Results: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics. Conclusions: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI. PMID:23596068

  14. Hodge Decomposition of Information Flow on Small-World Networks.

    PubMed

    Haruna, Taichi; Fujiki, Yuuya

    2016-01-01

    We investigate the influence of the small-world topology on the composition of information flow on networks. By appealing to the combinatorial Hodge theory, we decompose information flow generated by random threshold networks on the Watts-Strogatz model into three components: gradient, harmonic and curl flows. The harmonic and curl flows represent globally circular and locally circular components, respectively. The Watts-Strogatz model bridges the two extreme network topologies, a lattice network and a random network, by a single parameter that is the probability of random rewiring. The small-world topology is realized within a certain range between them. By numerical simulation we found that as networks become more random the ratio of harmonic flow to the total magnitude of information flow increases whereas the ratio of curl flow decreases. Furthermore, both quantities are significantly enhanced from the level when only network structure is considered for the network close to a random network and a lattice network, respectively. Finally, the sum of these two ratios takes its maximum value within the small-world region. These findings suggest that the dynamical information counterpart of global integration and that of local segregation are the harmonic flow and the curl flow, respectively, and that a part of the small-world region is dominated by internal circulation of information flow.

  15. Geometric Assortative Growth Model for Small-World Networks

    PubMed Central

    2014-01-01

    It has been shown that both humanly constructed and natural networks are often characterized by small-world phenomenon and assortative mixing. In this paper, we propose a geometrically growing model for small-world networks. The model displays both tunable small-world phenomenon and tunable assortativity. We obtain analytical solutions of relevant topological properties such as order, size, degree distribution, degree correlation, clustering, transitivity, and diameter. It is also worth noting that the model can be viewed as a generalization for an iterative construction of Farey graphs. PMID:24578661

  16. Architecture of marine food webs: To be or not be a 'small-world'.

    PubMed

    Marina, Tomás Ignacio; Saravia, Leonardo A; Cordone, Georgina; Salinas, Vanesa; Doyle, Santiago R; Momo, Fernando R

    2018-01-01

    The search for general properties in network structure has been a central issue for food web studies in recent years. One such property is the small-world topology that combines a high clustering and a small distance between nodes of the network. This property may increase food web resilience but make them more sensitive to the extinction of connected species. Food web theory has been developed principally from freshwater and terrestrial ecosystems, largely omitting marine habitats. If theory needs to be modified to accommodate observations from marine ecosystems, based on major differences in several topological characteristics is still on debate. Here we investigated if the small-world topology is a common structural pattern in marine food webs. We developed a novel, simple and statistically rigorous method to examine the largest set of complex marine food webs to date. More than half of the analyzed marine networks exhibited a similar or lower characteristic path length than the random expectation, whereas 39% of the webs presented a significantly higher clustering than its random counterpart. Our method proved that 5 out of 28 networks fulfilled both features of the small-world topology: short path length and high clustering. This work represents the first rigorous analysis of the small-world topology and its associated features in high-quality marine networks. We conclude that such topology is a structural pattern that is not maximized in marine food webs; thus it is probably not an effective model to study robustness, stability and feasibility of marine ecosystems.

  17. Collective dynamics of 'small-world' networks.

    PubMed

    Watts, D J; Strogatz, S H

    1998-06-04

    Networks of coupled dynamical systems have been used to model biological oscillators, Josephson junction arrays, excitable media, neural networks, spatial games, genetic control networks and many other self-organizing systems. Ordinarily, the connection topology is assumed to be either completely regular or completely random. But many biological, technological and social networks lie somewhere between these two extremes. Here we explore simple models of networks that can be tuned through this middle ground: regular networks 'rewired' to introduce increasing amounts of disorder. We find that these systems can be highly clustered, like regular lattices, yet have small characteristic path lengths, like random graphs. We call them 'small-world' networks, by analogy with the small-world phenomenon (popularly known as six degrees of separation. The neural network of the worm Caenorhabditis elegans, the power grid of the western United States, and the collaboration graph of film actors are shown to be small-world networks. Models of dynamical systems with small-world coupling display enhanced signal-propagation speed, computational power, and synchronizability. In particular, infectious diseases spread more easily in small-world networks than in regular lattices.

  18. Characterization and control of small-world networks.

    PubMed

    Pandit, S A; Amritkar, R E

    1999-08-01

    Recently, Watts and Strogatz [Nature (London) 393, 440 (1998)] offered an interesting model of small-world networks. Here we concretize the concept of a "faraway" connection in a network by defining a far edge. Our definition is algorithmic and independent of any external parameters such as topology of the underlying space of the network. We show that it is possible to control the spread of an epidemic by using the knowledge of far edges. We also suggest a model for better product advertisement using the far edges. Our findings indicate that the number of far edges can be a good intrinsic parameter to characterize small-world phenomena.

  19. Characterization and control of small-world networks

    NASA Astrophysics Data System (ADS)

    Pandit, S. A.; Amritkar, R. E.

    1999-08-01

    Recently, Watts and Strogatz [Nature (London) 393, 440 (1998)] offered an interesting model of small-world networks. Here we concretize the concept of a ``faraway'' connection in a network by defining a far edge. Our definition is algorithmic and independent of any external parameters such as topology of the underlying space of the network. We show that it is possible to control the spread of an epidemic by using the knowledge of far edges. We also suggest a model for better product advertisement using the far edges. Our findings indicate that the number of far edges can be a good intrinsic parameter to characterize small-world phenomena.

  20. The relations between network-operation and topological-property in a scale-free and small-world network with community structure

    NASA Astrophysics Data System (ADS)

    Ma, Fei; Yao, Bing

    2017-10-01

    It is always an open, demanding and difficult task for generating available model to simulate dynamical functions and reveal inner principles from complex systems and networks. In this article, due to lots of real-life and artificial networks are built from series of simple and small groups (components), we discuss some interesting and helpful network-operation to generate more realistic network models. In view of community structure (modular topology), we present a class of sparse network models N(t , m) . At the moment, we capture the fact the N(t , 4) has not only scale-free feature, which means that the probability that a randomly selected vertex with degree k decays as a power-law, following P(k) ∼k-γ, where γ is the degree exponent, but also small-world property, which indicates that the typical distance between two uniform randomly chosen vertices grows proportionally to logarithm of the order of N(t , 4) , namely, relatively shorter diameter and lower average path length, simultaneously displays higher clustering coefficient. Next, as a new topological parameter correlating to reliability, synchronization capability and diffusion properties of networks, the number of spanning trees over a network is studied in more detail, an exact analytical solution for the number of spanning trees of the N(t , 4) is obtained. Based on the network-operation, part hub-vertex linking with each other will be helpful for structuring various network models and investigating the rules related with real-life networks.

  1. Identifying Turbulent Structures through Topological Segmentation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bremer, Peer-Timo; Gruber, Andrea; Bennett, Janine C.

    2016-01-01

    A new method of extracting vortical structures from a turbulent flow is proposed whereby topological segmentation of an indicator function scalar field is used to identify the regions of influence of the individual vortices. This addresses a long-standing challenge in vector field topological analysis: indicator functions commonly used produce a scalar field based on the local velocity vector field; reconstructing regions of influence for a particular structure requires selecting a threshold to define vortex extent. In practice, the same threshold is rarely meaningful throughout a given flow. By also considering the topology of the indicator field function, the characteristics ofmore » vortex strength and extent can be separated and the ambiguity in the choice of the threshold reduced. The proposed approach is able to identify several types of vortices observed in a jet in cross-flow configuration simultaneously where no single threshold value for a selection of common indicator functions appears able to identify all of these vortex types.« less

  2. Right-side-stretched multifractal spectra indicate small-worldness in networks

    NASA Astrophysics Data System (ADS)

    Oświȩcimka, Paweł; Livi, Lorenzo; Drożdż, Stanisław

    2018-04-01

    Complex network formalism allows to explain the behavior of systems composed by interacting units. Several prototypical network models have been proposed thus far. The small-world model has been introduced to mimic two important features observed in real-world systems: i) local clustering and ii) the possibility to move across a network by means of long-range links that significantly reduce the characteristic path length. A natural question would be whether there exist several ;types; of small-world architectures, giving rise to a continuum of models with properties (partially) shared with other models belonging to different network families. Here, we take advantage of the interplay between network theory and time series analysis and propose to investigate small-world signatures in complex networks by analyzing multifractal characteristics of time series generated from such networks. In particular, we suggest that the degree of right-sided asymmetry of multifractal spectra is linked with the degree of small-worldness present in networks. This claim is supported by numerical simulations performed on several parametric models, including prototypical small-world networks, scale-free, fractal and also real-world networks describing protein molecules. Our results also indicate that right-sided asymmetry emerges with the presence of the following topological properties: low edge density, low average shortest path, and high clustering coefficient.

  3. Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity

    PubMed Central

    Luongo, Francisco J.; Zimmerman, Chris A.; Horn, Meryl E.

    2016-01-01

    Sequential patterns of prefrontal activity are believed to mediate important behaviors, e.g., working memory, but it remains unclear exactly how they are generated. In accordance with previous studies of cortical circuits, we found that prefrontal microcircuits in young adult mice spontaneously generate many more stereotyped sequences of activity than expected by chance. However, the key question of whether these sequences depend on a specific functional organization within the cortical microcircuit, or emerge simply as a by-product of random interactions between neurons, remains unanswered. We observed that correlations between prefrontal neurons do follow a specific functional organization—they have a small-world topology. However, until now it has not been possible to directly link small-world topologies to specific circuit functions, e.g., sequence generation. Therefore, we developed a novel analysis to address this issue. Specifically, we constructed surrogate data sets that have identical levels of network activity at every point in time but nevertheless represent various network topologies. We call this method shuffling activity to rearrange correlations (SHARC). We found that only surrogate data sets based on the actual small-world functional organization of prefrontal microcircuits were able to reproduce the levels of sequences observed in actual data. As expected, small-world data sets contained many more sequences than surrogate data sets with randomly arranged correlations. Surprisingly, small-world data sets also outperformed data sets in which correlations were maximally clustered. Thus the small-world functional organization of cortical microcircuits, which effectively balances the random and maximally clustered regimes, is optimal for producing stereotyped sequential patterns of activity. PMID:26888108

  4. Influence of Choice of Null Network on Small-World Parameters of Structural Correlation Networks

    PubMed Central

    Hosseini, S. M. Hadi; Kesler, Shelli R.

    2013-01-01

    In recent years, coordinated variations in brain morphology (e.g., volume, thickness) have been employed as a measure of structural association between brain regions to infer large-scale structural correlation networks. Recent evidence suggests that brain networks constructed in this manner are inherently more clustered than random networks of the same size and degree. Thus, null networks constructed by randomizing topology are not a good choice for benchmarking small-world parameters of these networks. In the present report, we investigated the influence of choice of null networks on small-world parameters of gray matter correlation networks in healthy individuals and survivors of acute lymphoblastic leukemia. Three types of null networks were studied: 1) networks constructed by topology randomization (TOP), 2) networks matched to the distributional properties of the observed covariance matrix (HQS), and 3) networks generated from correlation of randomized input data (COR). The results revealed that the choice of null network not only influences the estimated small-world parameters, it also influences the results of between-group differences in small-world parameters. In addition, at higher network densities, the choice of null network influences the direction of group differences in network measures. Our data suggest that the choice of null network is quite crucial for interpretation of group differences in small-world parameters of structural correlation networks. We argue that none of the available null models is perfect for estimation of small-world parameters for correlation networks and the relative strengths and weaknesses of the selected model should be carefully considered with respect to obtained network measures. PMID:23840672

  5. Small worlds in space: Synchronization, spatial and relational modularity

    NASA Astrophysics Data System (ADS)

    Brede, M.

    2010-06-01

    In this letter we investigate networks that have been optimized to realize a trade-off between enhanced synchronization and cost of wire to connect the nodes in space. Analyzing the evolved arrangement of nodes in space and their corresponding network topology, a class of small-world networks characterized by spatial and network modularity is found. More precisely, for low cost of wire optimal configurations are characterized by a division of nodes into two spatial groups with maximum distance from each other, whereas network modularity is low. For high cost of wire, the nodes organize into several distinct groups in space that correspond to network modules connected on a ring. In between, spatially and relationally modular small-world networks are found.

  6. Identifying Two-Dimensional Z 2 Antiferromagnetic Topological Insulators

    NASA Astrophysics Data System (ADS)

    Bègue, F.; Pujol, P.; Ramazashvili, R.

    2018-01-01

    We revisit the question of whether a two-dimensional topological insulator may arise in a commensurate Néel antiferromagnet, where staggered magnetization breaks the symmetry with respect to both elementary translation and time reversal, but retains their product as a symmetry. In contrast to the so-called Z 2 topological insulators, an exhaustive characterization of antiferromagnetic topological phases with the help of topological invariants has been missing. We analyze a simple model of an antiferromagnetic topological insulator and chart its phase diagram, using a recently proposed criterion for centrosymmetric systems [13]. We then adapt two methods, originally designed for paramagnetic systems, and make antiferromagnetic topological phases manifest. The proposed methods apply far beyond the particular examples treated in this work, and admit straightforward generalization. We illustrate this by two examples of non-centrosymmetric systems, where no simple criteria have been known to identify topological phases. We also present, for some cases, an explicit construction of edge states in an antiferromagnetic topological insulator.

  7. Damage spreading in spatial and small-world random Boolean networks

    NASA Astrophysics Data System (ADS)

    Lu, Qiming; Teuscher, Christof

    2014-02-01

    The study of the response of complex dynamical social, biological, or technological networks to external perturbations has numerous applications. Random Boolean networks (RBNs) are commonly used as a simple generic model for certain dynamics of complex systems. Traditionally, RBNs are interconnected randomly and without considering any spatial extension and arrangement of the links and nodes. However, most real-world networks are spatially extended and arranged with regular, power-law, small-world, or other nonrandom connections. Here we explore the RBN network topology between extreme local connections, random small-world, and pure random networks, and study the damage spreading with small perturbations. We find that spatially local connections change the scaling of the Hamming distance at very low connectivities (K¯≪1) and that the critical connectivity of stability Ks changes compared to random networks. At higher K¯, this scaling remains unchanged. We also show that the Hamming distance of spatially local networks scales with a power law as the system size N increases, but with a different exponent for local and small-world networks. The scaling arguments for small-world networks are obtained with respect to the system sizes and strength of spatially local connections. We further investigate the wiring cost of the networks. From an engineering perspective, our new findings provide the key design trade-offs between damage spreading (robustness), the network's wiring cost, and the network's communication characteristics.

  8. Topology of Neutral Hydrogen within the Small Magellanic Cloud

    NASA Astrophysics Data System (ADS)

    Chepurnov, A.; Gordon, J.; Lazarian, A.; Stanimirovic, S.

    2008-12-01

    In this paper, genus statistics have been applied to an H I column density map of the Small Magellanic Cloud in order to study its topology. To learn how topology changes with the scale of the system, we provide topology studies for column density maps at varying resolutions. To evaluate the statistical error of the genus, we randomly reassign the phases of the Fourier modes while keeping the amplitudes. We find that at the smallest scales studied (40 pc <= λ <= 80 pc), the genus shift is negative in all regions, implying a clump topology. At the larger scales (110 pc <= λ <= 250 pc), the topology shift is detected to be negative (a "meatball" topology) in four cases and positive (a "swiss cheese" topology) in two cases. In four regions, there is no statistically significant topology shift at large scales.

  9. Driving and driven architectures of directed small-world human brain functional networks.

    PubMed

    Yan, Chaogan; He, Yong

    2011-01-01

    Recently, increasing attention has been focused on the investigation of the human brain connectome that describes the patterns of structural and functional connectivity networks of the human brain. Many studies of the human connectome have demonstrated that the brain network follows a small-world topology with an intrinsically cohesive modular structure and includes several network hubs in the medial parietal regions. However, most of these studies have only focused on undirected connections between regions in which the directions of information flow are not taken into account. How the brain regions causally influence each other and how the directed network of human brain is topologically organized remain largely unknown. Here, we applied linear multivariate Granger causality analysis (GCA) and graph theoretical approaches to a resting-state functional MRI dataset with a large cohort of young healthy participants (n = 86) to explore connectivity patterns of the population-based whole-brain functional directed network. This directed brain network exhibited prominent small-world properties, which obviously improved previous results of functional MRI studies showing weak small-world properties in the directed brain networks in terms of a kernel-based GCA and individual analysis. This brain network also showed significant modular structures associated with 5 well known subsystems: fronto-parietal, visual, paralimbic/limbic, subcortical and primary systems. Importantly, we identified several driving hubs predominantly located in the components of the attentional network (e.g., the inferior frontal gyrus, supplementary motor area, insula and fusiform gyrus) and several driven hubs predominantly located in the components of the default mode network (e.g., the precuneus, posterior cingulate gyrus, medial prefrontal cortex and inferior parietal lobule). Further split-half analyses indicated that our results were highly reproducible between two independent subgroups. The

  10. A family of small-world network models built by complete graph and iteration-function

    NASA Astrophysics Data System (ADS)

    Ma, Fei; Yao, Bing

    2018-02-01

    Small-world networks are popular in real-life complex systems. In the past few decades, researchers presented amounts of small-world models, in which some are stochastic and the rest are deterministic. In comparison with random models, it is not only convenient but also interesting to study the topological properties of deterministic models in some fields, such as graph theory, theorem computer sciences and so on. As another concerned darling in current researches, community structure (modular topology) is referred to as an useful statistical parameter to uncover the operating functions of network. So, building and studying such models with community structure and small-world character will be a demanded task. Hence, in this article, we build a family of sparse network space N(t) which is different from those previous deterministic models. Even though, our models are established in the same way as them, iterative generation. By randomly connecting manner in each time step, every resulting member in N(t) has no absolutely self-similar feature widely shared in a large number of previous models. This makes our insight not into discussing a class certain model, but into investigating a group various ones spanning a network space. Somewhat surprisingly, our results prove all members of N(t) to possess some similar characters: (a) sparsity, (b) exponential-scale feature P(k) ∼α-k, and (c) small-world property. Here, we must stress a very screming, but intriguing, phenomenon that the difference of average path length (APL) between any two members in N(t) is quite small, which indicates this random connecting way among members has no great effect on APL. At the end of this article, as a new topological parameter correlated to reliability, synchronization capability and diffusion properties of networks, the number of spanning trees on a representative member NB(t) of N(t) is studied in detail, then an exact analytical solution for its spanning trees entropy is also

  11. Social influence in small-world networks

    NASA Astrophysics Data System (ADS)

    Sun, Kai; Mao, Xiao-Ming; Ouyang, Qi

    2002-12-01

    We report on our numerical studies of the Axelrod model for social influence in small-world networks. Our simulation results show that the topology of the network has a crucial effect on the evolution of cultures. As the randomness of the network increases, the system undergoes a transition from a highly fragmented phase to a uniform phase. We also find that the power-law distribution at the transition point, reported by Castellano et al, is not a critical phenomenon; it exists not only at the onset of transition but also for almost any control parameters. All these power-law distributions are stable against perturbations. A mean-field theory is developed to explain these phenomena.

  12. Mandala Networks: ultra-small-world and highly sparse graphs

    PubMed Central

    Sampaio Filho, Cesar I. N.; Moreira, André A.; Andrade, Roberto F. S.; Herrmann, Hans J.; Andrade, José S.

    2015-01-01

    The increasing demands in security and reliability of infrastructures call for the optimal design of their embedded complex networks topologies. The following question then arises: what is the optimal layout to fulfill best all the demands? Here we present a general solution for this problem with scale-free networks, like the Internet and airline networks. Precisely, we disclose a way to systematically construct networks which are robust against random failures. Furthermore, as the size of the network increases, its shortest path becomes asymptotically invariant and the density of links goes to zero, making it ultra-small world and highly sparse, respectively. The first property is ideal for communication and navigation purposes, while the second is interesting economically. Finally, we show that some simple changes on the original network formulation can lead to an improved topology against malicious attacks. PMID:25765450

  13. Levodopa modulates small-world architecture of functional brain networks in Parkinson's disease.

    PubMed

    Berman, Brian D; Smucny, Jason; Wylie, Korey P; Shelton, Erika; Kronberg, Eugene; Leehey, Maureen; Tregellas, Jason R

    2016-11-01

    PD is associated with disrupted connectivity to a large number of distributed brain regions. How the disease alters the functional topological organization of the brain, however, remains poorly understood. Furthermore, how levodopa modulates network topology in PD is largely unknown. The objective of this study was to use resting-state functional MRI and graph theory to determine how small-world architecture is altered in PD and affected by levodopa administration. Twenty-one PD patients and 20 controls underwent functional MRI scanning. PD patients were scanned off medication and 1 hour after 200 mg levodopa. Imaging data were analyzed using 226 nodes comprising 10 intrinsic brain networks. Correlation matrices were generated for each subject and converted into cost-thresholded, binarized adjacency matrices. Cost-integrated whole-brain global and local efficiencies were compared across groups and tested for relationships with disease duration and severity. Data from 2 patients and 4 controls were excluded because of excess motion. Patients off medication showed no significant changes in global efficiency and overall local efficiency, but in a subnetwork analysis did show increased local efficiency in executive (P = 0.006) and salience (P = 0.018) networks. Levodopa significantly decreased local efficiency (P = 0.039) in patients except within the subcortical network, in which it significantly increased local efficiency (P = 0.007). Levodopa modulates global and local efficiency measures of small-world topology in PD, suggesting that degeneration of nigrostriatal neurons in PD may be associated with a large-scale network reorganization and that levodopa tends to normalize the disrupted network topology in PD. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.

  14. Critical behavior of the XY-rotor model on regular and small-world networks

    NASA Astrophysics Data System (ADS)

    De Nigris, Sarah; Leoncini, Xavier

    2013-07-01

    We study the XY rotors model on small networks whose number of links scales with the system size Nlinks˜Nγ, where 1≤γ≤2. We first focus on regular one-dimensional rings in the microcanonical ensemble. For γ<1.5 the model behaves like a short-range one and no phase transition occurs. For γ>1.5, the system equilibrium properties are found to be identical to the mean field, which displays a second-order phase transition at a critical energy density ɛ=E/N,ɛc=0.75. Moreover, for γc≃1.5 we find that a nontrivial state emerges, characterized by an infinite susceptibility. We then consider small-world networks, using the Watts-Strogatz mechanism on the regular networks parametrized by γ. We first analyze the topology and find that the small-world regime appears for rewiring probabilities which scale as pSW∝1/Nγ. Then considering the XY-rotors model on these networks, we find that a second-order phase transition occurs at a critical energy ɛc which logarithmically depends on the topological parameters p and γ. We also define a critical probability pMF, corresponding to the probability beyond which the mean field is quantitatively recovered, and we analyze its dependence on γ.

  15. A game-theoretic approach to optimize ad hoc networks inspired by small-world network topology

    NASA Astrophysics Data System (ADS)

    Tan, Mian; Yang, Tinghong; Chen, Xing; Yang, Gang; Zhu, Guoqing; Holme, Petter; Zhao, Jing

    2018-03-01

    Nodes in ad hoc networks are connected in a self-organized manner. Limited communication radius makes information transmit in multi-hop mode, and each forwarding needs to consume the energy of nodes. Insufficient communication radius or exhaustion of energy may cause the absence of some relay nodes and links, further breaking network connectivity. On the other hand, nodes in the network may refuse to cooperate due to objective faulty or personal selfish, hindering regular communication in the network. This paper proposes a model called Repeated Game in Small World Networks (RGSWN). In this model, we first construct ad hoc networks with small-world feature by forming "communication shortcuts" between multiple-radio nodes. Small characteristic path length reduces average forwarding times in networks; meanwhile high clustering coefficient enhances network robustness. Such networks still maintain relative low global power consumption, which is beneficial to extend the network survival time. Then we use MTTFT strategy (Mend-Tolerance Tit-for-Tat) for repeated game as a rule for the interactions between neighbors in the small-world networks. Compared with other five strategies of repeated game, this strategy not only punishes the nodes' selfishness more reasonably, but also has the best tolerance to the network failure. This work is insightful for designing an efficient and robust ad hoc network.

  16. Toward topology-based characterization of small-scale mixing in compressible turbulence

    NASA Astrophysics Data System (ADS)

    Suman, Sawan; Girimaji, Sharath

    2011-11-01

    Turbulent mixing rate at small scales of motion (molecular mixing) is governed by the steepness of the scalar-gradient field which in turn is dependent upon the prevailing velocity gradients. Thus motivated, we propose a velocity-gradient topology-based approach for characterizing small-scale mixing in compressible turbulence. We define a mixing efficiency metric that is dependent upon the topology of the solenoidal and dilatational deformation rates of a fluid element. The mixing characteristics of solenoidal and dilatational velocity fluctuations are clearly delineated. We validate this new approach by employing mixing data from direct numerical simulations (DNS) of compressible decaying turbulence with passive scalar. For each velocity-gradient topology, we compare the mixing efficiency predicted by the topology-based model with the corresponding conditional scalar variance obtained from DNS. The new mixing metric accurately distinguishes good and poor mixing topologies and indeed reasonably captures the numerical values. The results clearly demonstrate the viability of the proposed approach for characterizing and predicting mixing in compressible flows.

  17. Modes of Interaction between Individuals Dominate the Topologies of Real World Networks

    PubMed Central

    Lee, Insuk; Kim, Eiru; Marcotte, Edward M.

    2015-01-01

    We find that the topologies of real world networks, such as those formed within human societies, by the Internet, or among cellular proteins, are dominated by the mode of the interactions considered among the individuals. Specifically, a major dichotomy in previously studied networks arises from modeling networks in terms of pairwise versus group tasks. The former often intrinsically give rise to scale-free, disassortative, hierarchical networks, whereas the latter often give rise to single- or broad-scale, assortative, nonhierarchical networks. These dependencies explain contrasting observations among previous topological analyses of real world complex systems. We also observe this trend in systems with natural hierarchies, in which alternate representations of the same networks, but which capture different levels of the hierarchy, manifest these signature topological differences. For example, in both the Internet and cellular proteomes, networks of lower-level system components (routers within domains or proteins within biological processes) are assortative and nonhierarchical, whereas networks of upper-level system components (internet domains or biological processes) are disassortative and hierarchical. Our results demonstrate that network topologies of complex systems must be interpreted in light of their hierarchical natures and interaction types. PMID:25793969

  18. Z2Pack: Numerical implementation of hybrid Wannier centers for identifying topological materials

    NASA Astrophysics Data System (ADS)

    Gresch, Dominik; Autès, Gabriel; Yazyev, Oleg V.; Troyer, Matthias; Vanderbilt, David; Bernevig, B. Andrei; Soluyanov, Alexey A.

    2017-02-01

    The intense theoretical and experimental interest in topological insulators and semimetals has established band structure topology as a fundamental material property. Consequently, identifying band topologies has become an important, but often challenging, problem, with no exhaustive solution at the present time. In this work we compile a series of techniques, some previously known, that allow for a solution to this problem for a large set of the possible band topologies. The method is based on tracking hybrid Wannier charge centers computed for relevant Bloch states, and it works at all levels of materials modeling: continuous k .p models, tight-binding models, and ab initio calculations. We apply the method to compute and identify Chern, Z2, and crystalline topological insulators, as well as topological semimetal phases, using real material examples. Moreover, we provide a numerical implementation of this technique (the Z2Pack software package) that is ideally suited for high-throughput screening of materials databases for compounds with nontrivial topologies. We expect that our work will allow researchers to (a) identify topological materials optimal for experimental probes, (b) classify existing compounds, and (c) reveal materials that host novel, not yet described, topological states.

  19. Emergence of small-world structure in networks of spiking neurons through STDP plasticity.

    PubMed

    Basalyga, Gleb; Gleiser, Pablo M; Wennekers, Thomas

    2011-01-01

    In this work, we use a complex network approach to investigate how a neural network structure changes under synaptic plasticity. In particular, we consider a network of conductance-based, single-compartment integrate-and-fire excitatory and inhibitory neurons. Initially the neurons are connected randomly with uniformly distributed synaptic weights. The weights of excitatory connections can be strengthened or weakened during spiking activity by the mechanism known as spike-timing-dependent plasticity (STDP). We extract a binary directed connection matrix by thresholding the weights of the excitatory connections at every simulation step and calculate its major topological characteristics such as the network clustering coefficient, characteristic path length and small-world index. We numerically demonstrate that, under certain conditions, a nontrivial small-world structure can emerge from a random initial network subject to STDP learning.

  20. Effects of spike-time-dependent plasticity on the stochastic resonance of small-world neuronal networks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Haitao; Guo, Xinmeng; Wang, Jiang, E-mail: jiangwang@tju.edu.cn

    2014-09-01

    The phenomenon of stochastic resonance in Newman-Watts small-world neuronal networks is investigated when the strength of synaptic connections between neurons is adaptively adjusted by spike-time-dependent plasticity (STDP). It is shown that irrespective of the synaptic connectivity is fixed or adaptive, the phenomenon of stochastic resonance occurs. The efficiency of network stochastic resonance can be largely enhanced by STDP in the coupling process. Particularly, the resonance for adaptive coupling can reach a much larger value than that for fixed one when the noise intensity is small or intermediate. STDP with dominant depression and small temporal window ratio is more efficient formore » the transmission of weak external signal in small-world neuronal networks. In addition, we demonstrate that the effect of stochastic resonance can be further improved via fine-tuning of the average coupling strength of the adaptive network. Furthermore, the small-world topology can significantly affect stochastic resonance of excitable neuronal networks. It is found that there exists an optimal probability of adding links by which the noise-induced transmission of weak periodic signal peaks.« less

  1. Stretched exponential dynamics of coupled logistic maps on a small-world network

    NASA Astrophysics Data System (ADS)

    Mahajan, Ashwini V.; Gade, Prashant M.

    2018-02-01

    We investigate the dynamic phase transition from partially or fully arrested state to spatiotemporal chaos in coupled logistic maps on a small-world network. Persistence of local variables in a coarse grained sense acts as an excellent order parameter to study this transition. We investigate the phase diagram by varying coupling strength and small-world rewiring probability p of nonlocal connections. The persistent region is a compact region bounded by two critical lines where band-merging crisis occurs. On one critical line, the persistent sites shows a nonexponential (stretched exponential) decay for all p while for another one, it shows crossover from nonexponential to exponential behavior as p → 1 . With an effectively antiferromagnetic coupling, coupling to two neighbors on either side leads to exchange frustration. Apart from exchange frustration, non-bipartite topology and nonlocal couplings in a small-world network could be a reason for anomalous relaxation. The distribution of trap times in asymptotic regime has a long tail as well. The dependence of temporal evolution of persistence on initial conditions is studied and a scaling form for persistence after waiting time is proposed. We present a simple possible model for this behavior.

  2. Network topology analysis approach on China's QFII stock investment behavior

    NASA Astrophysics Data System (ADS)

    Zhang, Yongjie; Cao, Xing; He, Feng; Zhang, Wei

    2017-05-01

    In this paper, the investment behavior of QFII in China stock market from 2004 to 2015 is studied with the network topology method. Based on the nodes topological characteristics, stock holding fluctuations correlation is studied from the micro network level. We conclude that the QFII mutual stock holding network have both scale free and small world properties, which presented mainly small world characteristics from 2005 to 2011, and scale free characteristics from 2012 to 2015. Moreover, fluctuations correlation is different with different nodes topological characteristics. In different economic periods, QFII represented different connection patterns and they reacted to the market crash spontaneously. Thus, this paper provides the first evidence of complex network research on QFII' investment behavior in China as an emerging market.

  3. Optimal Topology Control and Power Allocation for Minimum Energy Consumption in Consensus Networks

    DTIC Science & Technology

    2011-12-16

    network topologies, such as small world graphs, can greatly increase the convergence rate. In [9], the authors show that nonbipartite Ramanujan graphs...unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 23384 IEEE TRANSACTIONS ON SIGNAL PROCESSING, VOL. 60...of iterations necessary to achieve consensus. From this perspec- tive, enforcing a small world, scale-free, or Ramanujan graph topology may not be the

  4. Topological Phases in the Real World

    NASA Astrophysics Data System (ADS)

    Hsu, Yi-Ting

    The experimental discovery and subsequent theoretical understanding of the integer quantum Hall effect, the first known topological phase, has started a revolutionary breakthrough in understanding states of matter since its discovery four decades ago. Topological phases are predicted to have many generic signatures resulting from their underlying topological nature, such as quantized Hall transport, robust boundary states, and possible fractional excitations. The intriguing nature of these signatures and their potential applications in quantum computation has intensely fueled the efforts of the physics community to materialize topological phases. Among various topological phases initially predicted on theoretical grounds, chiral topological superconductors and time-reversal symmetric topological insulators (TI) in three dimension (3D) are two promising candidates for experimental realization and application. The family of materials, Bi2X3 (X = Se, Te), has been predicted and shown experimentally to be time-reversal symmetric 3D TIs through the observation of robust Dirac surface states with Rashba-type spin-winding. Due to their robust surface states with spin-windings, these 3D TIs are expected to be promising materials for producing large spin-transfer torques which are advantageous for spintronics application. As for topological superconductors, despite the exotic excitations that have been extensively proposed as qubits for topological quantum computing, materials hosting topological superconductivity are rare to date and the leading candidate in two dimensions (2D), Sr 2RuO4, has a low transition temperature (Tc ). The goal of my phd study is to push forward the current status of realization of topological phases by materializing higher Tc topological superconductors and investigating the stability of Dirac surface states in 3D TIs. In the first part of this thesis, I will discuss our double-pronged objective for topological superconductors: to propose how to

  5. Robustness of cluster synchronous patterns in small-world networks with inter-cluster co-competition balance

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Jianbao; Ma, Zhongjun, E-mail: mzj1234402@163.com; Chen, Guanrong

    All edges in the classical Watts and Strogatz's small-world network model are unweighted and cooperative (positive). By introducing competitive (negative) inter-cluster edges and assigning edge weights to mimic more realistic networks, this paper develops a modified model which possesses co-competitive weighted couplings and cluster structures while maintaining the common small-world network properties of small average shortest path lengths and large clustering coefficients. Based on theoretical analysis, it is proved that the new model with inter-cluster co-competition balance has an important dynamical property of robust cluster synchronous pattern formation. More precisely, clusters will neither merge nor split regardless of adding ormore » deleting nodes and edges, under the condition of inter-cluster co-competition balance. Numerical simulations demonstrate the robustness of the model against the increase of the coupling strength and several topological variations.« less

  6. Robustness of cluster synchronous patterns in small-world networks with inter-cluster co-competition balance

    NASA Astrophysics Data System (ADS)

    Zhang, Jianbao; Ma, Zhongjun; Chen, Guanrong

    2014-06-01

    All edges in the classical Watts and Strogatz's small-world network model are unweighted and cooperative (positive). By introducing competitive (negative) inter-cluster edges and assigning edge weights to mimic more realistic networks, this paper develops a modified model which possesses co-competitive weighted couplings and cluster structures while maintaining the common small-world network properties of small average shortest path lengths and large clustering coefficients. Based on theoretical analysis, it is proved that the new model with inter-cluster co-competition balance has an important dynamical property of robust cluster synchronous pattern formation. More precisely, clusters will neither merge nor split regardless of adding or deleting nodes and edges, under the condition of inter-cluster co-competition balance. Numerical simulations demonstrate the robustness of the model against the increase of the coupling strength and several topological variations.

  7. Interictal to Ictal Phase Transition in a Small-World Network

    NASA Astrophysics Data System (ADS)

    Nemzer, Louis; Cravens, Gary; Worth, Robert

    Real-time detection and prediction of seizures in patients with epilepsy is essential for rapid intervention. Here, we perform a full Hodgkin-Huxley calculation using n 50 in silico neurons configured in a small-world network topology to generate simulated EEG signals. The connectivity matrix, constructed using a Watts-Strogatz algorithm, admits randomized or deterministic entries. We find that situations corresponding to interictal (non-seizure) and ictal (seizure) states are separated by a phase transition that can be influenced by congenital channelopathies, anticonvulsant drugs, and connectome plasticity. The interictal phase exhibits scale-free phenomena, as characterized by a power law form of the spectral power density, while the ictal state suffers from pathological synchronization. We compare the results with intracranial EEG data and show how these findings may be used to detect or even predict seizure onset. Along with the balance of excitatory and inhibitory factors, the network topology plays a large role in determining the overall characteristics of brain activity. We have developed a new platform for testing the conditions that contribute to the phase transition between non-seizure and seizure states.

  8. The topology of large Open Connectome networks for the human brain.

    PubMed

    Gastner, Michael T; Ódor, Géza

    2016-06-07

    The structural human connectome (i.e. the network of fiber connections in the brain) can be analyzed at ever finer spatial resolution thanks to advances in neuroimaging. Here we analyze several large data sets for the human brain network made available by the Open Connectome Project. We apply statistical model selection to characterize the degree distributions of graphs containing up to nodes and edges. A three-parameter generalized Weibull (also known as a stretched exponential) distribution is a good fit to most of the observed degree distributions. For almost all networks, simple power laws cannot fit the data, but in some cases there is statistical support for power laws with an exponential cutoff. We also calculate the topological (graph) dimension D and the small-world coefficient σ of these networks. While σ suggests a small-world topology, we found that D < 4 showing that long-distance connections provide only a small correction to the topology of the embedding three-dimensional space.

  9. The topology of large Open Connectome networks for the human brain

    NASA Astrophysics Data System (ADS)

    Gastner, Michael T.; Ódor, Géza

    2016-06-01

    The structural human connectome (i.e. the network of fiber connections in the brain) can be analyzed at ever finer spatial resolution thanks to advances in neuroimaging. Here we analyze several large data sets for the human brain network made available by the Open Connectome Project. We apply statistical model selection to characterize the degree distributions of graphs containing up to nodes and edges. A three-parameter generalized Weibull (also known as a stretched exponential) distribution is a good fit to most of the observed degree distributions. For almost all networks, simple power laws cannot fit the data, but in some cases there is statistical support for power laws with an exponential cutoff. We also calculate the topological (graph) dimension D and the small-world coefficient σ of these networks. While σ suggests a small-world topology, we found that D < 4 showing that long-distance connections provide only a small correction to the topology of the embedding three-dimensional space.

  10. Scale-free characteristics of random networks: the topology of the world-wide web

    NASA Astrophysics Data System (ADS)

    Barabási, Albert-László; Albert, Réka; Jeong, Hawoong

    2000-06-01

    The world-wide web forms a large directed graph, whose vertices are documents and edges are links pointing from one document to another. Here we demonstrate that despite its apparent random character, the topology of this graph has a number of universal scale-free characteristics. We introduce a model that leads to a scale-free network, capturing in a minimal fashion the self-organization processes governing the world-wide web.

  11. Stochastic resonance enhancement of small-world neural networks by hybrid synapses and time delay

    NASA Astrophysics Data System (ADS)

    Yu, Haitao; Guo, Xinmeng; Wang, Jiang

    2017-01-01

    The synergistic effect of hybrid electrical-chemical synapses and information transmission delay on the stochastic response behavior in small-world neuronal networks is investigated. Numerical results show that, the stochastic response behavior can be regulated by moderate noise intensity to track the rhythm of subthreshold pacemaker, indicating the occurrence of stochastic resonance (SR) in the considered neural system. Inheriting the characteristics of two types of synapses-electrical and chemical ones, neural networks with hybrid electrical-chemical synapses are of great improvement in neuron communication. Particularly, chemical synapses are conducive to increase the network detectability by lowering the resonance noise intensity, while the information is better transmitted through the networks via electrical coupling. Moreover, time delay is able to enhance or destroy the periodic stochastic response behavior intermittently. In the time-delayed small-world neuronal networks, the introduction of electrical synapses can significantly improve the signal detection capability by widening the range of optimal noise intensity for the subthreshold signal, and the efficiency of SR is largely amplified in the case of pure chemical couplings. In addition, the stochastic response behavior is also profoundly influenced by the network topology. Increasing the rewiring probability in pure chemically coupled networks can always enhance the effect of SR, which is slightly influenced by information transmission delay. On the other hand, the capacity of information communication is robust to the network topology within the time-delayed neuronal systems including electrical couplings.

  12. Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children.

    PubMed

    Wen, Hongwei; Liu, Yue; Rekik, Islem; Wang, Shengpei; Zhang, Jishui; Zhang, Yue; Peng, Yun; He, Huiguang

    2017-08-01

    Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder. Although previous TS studies revealed structural abnormalities in distinct corticobasal ganglia circuits, the topological alterations of the whole-brain white matter (WM) structural networks remain poorly understood. Here, we used diffusion MRI probabilistic tractography and graph theoretical analysis to investigate the topological organization of WM networks in 44 drug-naive TS children and 41 age- and gender-matched healthy children. The WM networks were constructed by estimating inter-regional connectivity probability and the topological properties were characterized using graph theory. We found that both TS and control groups showed an efficient small-world organization in WM networks. However, compared to controls, TS children exhibited decreased global and local efficiency, increased shortest path length and small worldness, indicating a disrupted balance between local specialization and global integration in structural networks. Although both TS and control groups showed highly similar hub distributions, TS children exhibited significant decreased nodal efficiency, mainly distributed in the default mode, language, visual, and sensorimotor systems. Furthermore, two separate networks showing significantly decreased connectivity in TS group were identified using network-based statistical (NBS) analysis, primarily composed of the parieto-occipital cortex, precuneus, and paracentral lobule. Importantly, we combined support vector machine and multiple kernel learning frameworks to fuse multiple levels of network topological features for classification of individuals, achieving high accuracy of 86.47%. Together, our study revealed the disrupted topological organization of structural networks related to pathophysiology of TS, and the discriminative topological features for classification are potential quantitative neuroimaging biomarkers for clinical TS diagnosis. Hum Brain Mapp 38:3988-4008, 2017

  13. Identifying partial topology of complex dynamical networks via a pinning mechanism

    NASA Astrophysics Data System (ADS)

    Zhu, Shuaibing; Zhou, Jin; Lu, Jun-an

    2018-04-01

    In this paper, we study the problem of identifying the partial topology of complex dynamical networks via a pinning mechanism. By using the network synchronization theory and the adaptive feedback controlling method, we propose a method which can greatly reduce the number of nodes and observers in the response network. Particularly, this method can also identify the whole topology of complex networks. A theorem is established rigorously, from which some corollaries are also derived in order to make our method more cost-effective. Several numerical examples are provided to verify the effectiveness of the proposed method. In the simulation, an approach is also given to avoid possible identification failure caused by inner synchronization of the drive network.

  14. Epidemics in interconnected small-world networks.

    PubMed

    Liu, Meng; Li, Daqing; Qin, Pengju; Liu, Chaoran; Wang, Huijuan; Wang, Feilong

    2015-01-01

    Networks can be used to describe the interconnections among individuals, which play an important role in the spread of disease. Although the small-world effect has been found to have a significant impact on epidemics in single networks, the small-world effect on epidemics in interconnected networks has rarely been considered. Here, we study the susceptible-infected-susceptible (SIS) model of epidemic spreading in a system comprising two interconnected small-world networks. We find that the epidemic threshold in such networks decreases when the rewiring probability of the component small-world networks increases. When the infection rate is low, the rewiring probability affects the global steady-state infection density, whereas when the infection rate is high, the infection density is insensitive to the rewiring probability. Moreover, epidemics in interconnected small-world networks are found to spread at different velocities that depend on the rewiring probability.

  15. Disrupted small world topology and modular organisation of functional networks in late-life depression with and without amnestic mild cognitive impairment.

    PubMed

    Li, Wenjun; Douglas Ward, B; Liu, Xiaolin; Chen, Gang; Jones, Jennifer L; Antuono, Piero G; Li, Shi-Jiang; Goveas, Joseph S

    2015-10-01

    The topological architecture of the whole-brain functional networks in those with and without late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are unknown. To investigate the differences in the small-world measures and the modular community structure of the functional networks between patients with LLD and aMCI when occurring alone or in combination and cognitively healthy non-depressed controls. 79 elderly participants (LLD (n=23), aMCI (n=18), comorbid LLD and aMCI (n=13), and controls (n=25)) completed neuropsychiatric assessments. Graph theoretical methods were employed on resting-state functional connectivity MRI data. LLD and aMCI comorbidity was associated with the greatest disruptions in functional integration measures (decreased global efficiency and increased path length); both LLD groups showed abnormal functional segregation (reduced local efficiency). The modular network organisation was most variable in the comorbid group, followed by patients with LLD-only. Decreased mean global, local and nodal efficiency metrics were associated with greater depressive symptom severity but not memory performance. Considering the whole brain as a complex network may provide unique insights on the neurobiological underpinnings of LLD with and without cognitive impairment. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Small-worldness characteristics and its gender relation in specific hemispheric networks.

    PubMed

    Miraglia, F; Vecchio, F; Bramanti, P; Rossini, P M

    2015-12-03

    Aim of this study was to verify whether the topological organization of human brain functional networks is different for males and females in resting state EEGs. Undirected and weighted brain networks were computed by eLORETA lagged linear connectivity in 130 subjects (59 males and 71 females) within each hemisphere and in four resting state networks (Attentional Network (AN), Frontal Network (FN), Sensorimotor Network (SN), Default Mode Network (DMN)). We found that small-world (SW) architecture in the left hemisphere Frontal network presented differences in both delta and alpha band, in particular lower values in delta and higher in alpha 2 in males respect to females while in the right hemisphere differences were found in lower values of SW in males respect to females in gamma Attentional, delta Sensorimotor and delta and gamma DMNs. Gender small-worldness differences in some of resting state networks indicated that there are specific brain differences in the EEG rhythms when the brain is in the resting-state condition. These specific regions could be considered related to the functions of behavior and cognition and should be taken into account both for research on healthy and brain diseased subjects. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  17. Large-scale cortical volume correlation networks reveal disrupted small world patterns in Parkinson's disease.

    PubMed

    Wu, Qiong; Gao, Yang; Liu, Ai-Shi; Xie, Li-Zhi; Qian, Long; Yang, Xiao-Guang

    2018-01-01

    To date, the most frequently reported neuroimaging biomarkers in Parkinson's disease (PD) are direct brain imaging measurements focusing on local disrupted regions. However, the notion that PD is related to abnormal functional and structural connectivity has received support in the past few years. Here, we employed graph theory to analyze the structural co-variance networks derived from 50 PD patients and 48 normal controls (NC). Then, the small world properties of brain networks were assessed in the structural networks that were constructed based on cortical volume data. Our results showed that both the PD and NC groups had a small world architecture in brain structural networks. However, the PD patients had a higher characteristic path length and clustering coefficients compared with the NC group. With regard to the nodal centrality, 11 regions, including 3 association cortices, 5 paralimbic cortices, and 3 subcortical regions were identified as hubs in the PD group. In contrast, 10 regions, including 7 association cortical regions, 2 paralimbic cortical regions, and the primary motor cortex region, were identified as hubs. Moreover, the regional centrality was profoundly affected in PD patients, including decreased nodal centrality in the right inferior occipital gyrus and the middle temporal gyrus and increased nodal centrality in the right amygdala, the left caudate and the superior temporal gyrus. In addition, the structural cortical network of PD showed reduced topological stability for targeted attacks. Together, this study shows that the coordinated patterns of cortical volume network are widely altered in PD patients with a decrease in the efficiency of parallel information processing. These changes provide structural evidence to support the concept that the core pathophysiology of PD is associated with disruptive alterations in the coordination of large-scale brain networks that underlie high-level cognition. Copyright © 2017. Published by Elsevier B.V.

  18. Small Worldness in Dense and Weighted Connectomes

    NASA Astrophysics Data System (ADS)

    Colon-Perez, Luis; Couret, Michelle; Triplett, William; Price, Catherine; Mareci, Thomas

    2016-05-01

    The human brain is a heterogeneous network of connected functional regions; however, most brain network studies assume that all brain connections can be described in a framework of binary connections. The brain is a complex structure of white matter tracts connected by a wide range of tract sizes, which suggests a broad range of connection strengths. Therefore, the assumption that the connections are binary yields an incomplete picture of the brain. Various thresholding methods have been used to remove spurious connections and reduce the graph density in binary networks. But these thresholds are arbitrary and make problematic the comparison of networks created at different thresholds. The heterogeneity of connection strengths can be represented in graph theory by applying weights to the network edges. Using our recently introduced edge weight parameter, we estimated the topological brain network organization using a complimentary weighted connectivity framework to the traditional framework of a binary network. To examine the reproducibility of brain networks in a controlled condition, we studied the topological network organization of a single healthy individual by acquiring 10 repeated diffusion-weighted magnetic resonance image datasets, over a one-month period on the same scanner, and analyzing these networks with deterministic tractography. We applied a threshold to both the binary and weighted networks and determined that the extra degree of freedom that comes with the framework of weighting network connectivity provides a robust result as any threshold level. The proposed weighted connectivity framework provides a stable result and is able to demonstrate the small world property of brain networks in situations where the binary framework is inadequate and unable to demonstrate this network property.

  19. Abnormal small-world brain functional networks in obsessive-compulsive disorder patients with poor insight.

    PubMed

    Lei, Hui; Cui, Yan; Fan, Jie; Zhang, Xiaocui; Zhong, Mingtian; Yi, Jinyao; Cai, Lin; Yao, Dezhong; Zhu, Xiongzhao

    2017-09-01

    There are limited data on neurobiological correlates of poor insight in obsessive-compulsive disorder (OCD). This study explored whether specific changes occur in small-world network (SWN) properties in the brain functional network of OCD patients with poor insight. Resting-state electroencephalograms (EEGs) were recorded for 12 medication-free OCD patients with poor insight, 50 medication-free OCD patients with good insight, and 36 healthy controls. Both of the OCD groups exhibited topological alterations in the brain functional network characterized by abnormal small-world parameters at the beta band. However, the alterations at the theta band only existed in the OCD patients with poor insight. A relatively small sample size. Subjects were naïve to medications and those with Axis I comorbidity were excluded, perhaps limiting generalizability. Disrupted functional integrity at the beta bands of the brain functional network may be related to OCD, while disrupted functional integrity at the theta band may be associated with poor insight in OCD patients, thus this study might provide novel insight into our understanding of the pathophysiology of OCD. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Low-rank network decomposition reveals structural characteristics of small-world networks

    NASA Astrophysics Data System (ADS)

    Barranca, Victor J.; Zhou, Douglas; Cai, David

    2015-12-01

    Small-world networks occur naturally throughout biological, technological, and social systems. With their prevalence, it is particularly important to prudently identify small-world networks and further characterize their unique connection structure with respect to network function. In this work we develop a formalism for classifying networks and identifying small-world structure using a decomposition of network connectivity matrices into low-rank and sparse components, corresponding to connections within clusters of highly connected nodes and sparse interconnections between clusters, respectively. We show that the network decomposition is independent of node indexing and define associated bounded measures of connectivity structure, which provide insight into the clustering and regularity of network connections. While many existing network characterizations rely on constructing benchmark networks for comparison or fail to describe the structural properties of relatively densely connected networks, our classification relies only on the intrinsic network structure and is quite robust with respect to changes in connection density, producing stable results across network realizations. Using this framework, we analyze several real-world networks and reveal new structural properties, which are often indiscernible by previously established characterizations of network connectivity.

  1. Small-world networks exhibit pronounced intermittent synchronization

    NASA Astrophysics Data System (ADS)

    Choudhary, Anshul; Mitra, Chiranjit; Kohar, Vivek; Sinha, Sudeshna; Kurths, Jürgen

    2017-11-01

    We report the phenomenon of temporally intermittently synchronized and desynchronized dynamics in Watts-Strogatz networks of chaotic Rössler oscillators. We consider topologies for which the master stability function (MSF) predicts stable synchronized behaviour, as the rewiring probability (p) is tuned from 0 to 1. MSF essentially utilizes the largest non-zero Lyapunov exponent transversal to the synchronization manifold in making stability considerations, thereby ignoring the other Lyapunov exponents. However, for an N-node networked dynamical system, we observe that the difference in its Lyapunov spectra (corresponding to the N - 1 directions transversal to the synchronization manifold) is crucial and serves as an indicator of the presence of intermittently synchronized behaviour. In addition to the linear stability-based (MSF) analysis, we further provide global stability estimate in terms of the fraction of state-space volume shared by the intermittently synchronized state, as p is varied from 0 to 1. This fraction becomes appreciably large in the small-world regime, which is surprising, since this limit has been otherwise considered optimal for synchronized dynamics. Finally, we characterize the nature of the observed intermittency and its dominance in state-space as network rewiring probability (p) is varied.

  2. Network topology of an experimental futures exchange

    NASA Astrophysics Data System (ADS)

    Wang, S. C.; Tseng, J. J.; Tai, C. C.; Lai, K. H.; Wu, W. S.; Chen, S. H.; Li, S. P.

    2008-03-01

    Many systems of different nature exhibit scale free behaviors. Economic systems with power law distribution in the wealth are one of the examples. To better understand the working behind the complexity, we undertook an experiment recording the interactions between market participants. A Web server was setup to administer the exchange of futures contracts whose liquidation prices were coupled to event outcomes. After free registration, participants started trading to compete for the money prizes upon maturity of the futures contracts at the end of the experiment. The evolving `cash' flow network was reconstructed from the transactions between players. We show that the network topology is hierarchical, disassortative and small-world with a power law exponent of 1.02±0.09 in the degree distribution after an exponential decay correction. The small-world property emerged early in the experiment while the number of participants was still small. We also show power law-like distributions of the net incomes and inter-transaction time intervals. Big winners and losers are associated with high degree, high betweenness centrality, low clustering coefficient and low degree-correlation. We identify communities in the network as groups of the like-minded. The distribution of the community sizes is shown to be power-law distributed with an exponent of 1.19±0.16.

  3. Small-worldness and gender differences of large scale brain metabolic covariance networks in young adults: a FDG PET study of 400 subjects.

    PubMed

    Hu, Yuxiao; Xu, Qiang; Shen, Junkang; Li, Kai; Zhu, Hong; Zhang, Zhiqiang; Lu, Guangming

    2015-02-01

    Many studies have demonstrated the small-worldness of the human brain, and have revealed a sexual dimorphism in brain network properties. However, little is known about the gender effects on the topological organization of the brain metabolic covariance networks. To investigate the small-worldness and the gender differences in the topological architectures of human brain metabolic networks. FDG-PET data of 400 healthy right-handed subjects (200 women and 200 age-matched men) were involved in the present study. Metabolic networks of each gender were constructed by calculating the covariance of regional cerebral glucose metabolism (rCMglc) across subjects on the basis of AAL parcellation. Gender differences of network and nodal properties were investigated by using the graph theoretical approaches. Moreover, the gender-related difference of rCMglc in each brain region was tested for investigating the relationships between the hub regions and the brain regions showing significant gender-related differences in rCMglc. We found prominent small-world properties in the domain of metabolic networks in each gender. No significant gender difference in the global characteristics was found. Gender differences of nodal characteristic were observed in a few brain regions. We also found bilateral and lateralized distributions of network hubs in the females and males. Furthermore, we first reported that some hubs of a gender located in the brain regions showing weaker rCMglc in this gender than the other gender. The present study demonstrated that small-worldness was existed in metabolic networks, and revealed gender differences of organizational patterns in metabolic network. These results maybe provided insights into the understanding of the metabolic substrates underlying individual differences in cognition and behaviors. © The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  4. Algebraic approach to small-world network models

    NASA Astrophysics Data System (ADS)

    Rudolph-Lilith, Michelle; Muller, Lyle E.

    2014-01-01

    We introduce an analytic model for directed Watts-Strogatz small-world graphs and deduce an algebraic expression of its defining adjacency matrix. The latter is then used to calculate the small-world digraph's asymmetry index and clustering coefficient in an analytically exact fashion, valid nonasymptotically for all graph sizes. The proposed approach is general and can be applied to all algebraically well-defined graph-theoretical measures, thus allowing for an analytical investigation of finite-size small-world graphs.

  5. A temperature monitor circuit with small voltage sensitivity using a topology-reconfigurable ring oscillator

    NASA Astrophysics Data System (ADS)

    Kishimoto, Tadashi; Ishihara, Tohru; Onodera, Hidetoshi

    2018-04-01

    In this paper, we propose a temperature monitor circuit that exhibits a small supply voltage sensitivity adopting a circuit topology of a reconfigurable ring oscillator. The circuit topology of the monitor is crafted such that the oscillation frequency is determined by the amount of subthreshold leakage current, which has an exponential dependence on temperature. Another important characteristic of the monitor is its small supply voltage sensitivity. The measured oscillation frequency of a test chip fabricated in a 65 nm CMOS process varies only 2.6% under a wide range of supply voltages from 0.4 to 1.0 V at room temperature. The temperature estimation error ranges from -0.3 to 0.4 °C over a temperature range of 10 to 100 °C.

  6. Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients.

    PubMed

    Qiu, Xiangzhe; Zhang, Yanjun; Feng, Hongbo; Jiang, Donglang

    2016-01-01

    Recent studies have demonstrated alterations in the topological organization of structural brain networks in diabetes mellitus (DM). However, the DM-related changes in the topological properties in functional brain networks are unexplored so far. We therefore used fluoro-D-glucose positron emission tomography (FDG-PET) data to construct functional brain networks of 73 DM patients and 91 sex- and age-matched normal controls (NCs), followed by a graph theoretical analysis. We found that both DM patients and NCs had a small-world topology in functional brain network. In comparison to the NC group, the DM group was found to have significantly lower small-world index, lower normalized clustering coefficients and higher normalized characteristic path length. Moreover, for diabetic patients, the nodal centrality was significantly reduced in the right rectus, the right cuneus, the left middle occipital gyrus, and the left postcentral gyrus, and it was significantly increased in the orbitofrontal region of the left middle frontal gyrus, the left olfactory region, and the right paracentral lobule. Our results demonstrated that the diabetic brain was associated with disrupted topological organization in the functional PET network, thus providing functional evidence for the abnormalities of brain networks in DM.

  7. Unimodular lattice triangulations as small-world and scale-free random graphs

    NASA Astrophysics Data System (ADS)

    Krüger, B.; Schmidt, E. M.; Mecke, K.

    2015-02-01

    Real-world networks, e.g., the social relations or world-wide-web graphs, exhibit both small-world and scale-free behaviour. We interpret lattice triangulations as planar graphs by identifying triangulation vertices with graph nodes and one-dimensional simplices with edges. Since these triangulations are ergodic with respect to a certain Pachner flip, applying different Monte Carlo simulations enables us to calculate average properties of random triangulations, as well as canonical ensemble averages, using an energy functional that is approximately the variance of the degree distribution. All considered triangulations have clustering coefficients comparable with real-world graphs; for the canonical ensemble there are inverse temperatures with small shortest path length independent of system size. Tuning the inverse temperature to a quasi-critical value leads to an indication of scale-free behaviour for degrees k≥slant 5. Using triangulations as a random graph model can improve the understanding of real-world networks, especially if the actual distance of the embedded nodes becomes important.

  8. A Small World of Neuronal Synchrony

    PubMed Central

    Yu, Shan; Huang, Debin; Singer, Wolf

    2008-01-01

    A small-world network has been suggested to be an efficient solution for achieving both modular and global processing—a property highly desirable for brain computations. Here, we investigated functional networks of cortical neurons using correlation analysis to identify functional connectivity. To reconstruct the interaction network, we applied the Ising model based on the principle of maximum entropy. This allowed us to assess the interactions by measuring pairwise correlations and to assess the strength of coupling from the degree of synchrony. Visual responses were recorded in visual cortex of anesthetized cats, simultaneously from up to 24 neurons. First, pairwise correlations captured most of the patterns in the population's activity and, therefore, provided a reliable basis for the reconstruction of the interaction networks. Second, and most importantly, the resulting networks had small-world properties; the average path lengths were as short as in simulated random networks, but the clustering coefficients were larger. Neurons differed considerably with respect to the number and strength of interactions, suggesting the existence of “hubs” in the network. Notably, there was no evidence for scale-free properties. These results suggest that cortical networks are optimized for the coexistence of local and global computations: feature detection and feature integration or binding. PMID:18400792

  9. The topology of the federal funds market

    NASA Astrophysics Data System (ADS)

    Bech, Morten L.; Atalay, Enghin

    2010-11-01

    We explore the network topology of the federal funds market. This market is important for distributing liquidity throughout the financial system and for the implementation of monetary policy. The recent turmoil in global financial markets underscores its importance. We find that the network is sparse, exhibits the small-world phenomenon, and is disassortative. Centrality measures are useful predictors of the interest rate of a loan.

  10. Individual T1-weighted/T2-weighted ratio brain networks: Small-worldness, hubs and modular organization

    NASA Astrophysics Data System (ADS)

    Wu, Huijun; Wang, Hao; Lü, Linyuan

    Applying network science to investigate the complex systems has become a hot topic. In neuroscience, understanding the architectures of complex brain networks was a vital issue. An enormous amount of evidence had supported the brain was cost/efficiency trade-off with small-worldness, hubness and modular organization through the functional MRI and structural MRI investigations. However, the T1-weighted/T2-weighted (T1w/T2w) ratio brain networks were mostly unexplored. Here, we utilized a KL divergence-based method to construct large-scale individual T1w/T2w ratio brain networks and investigated the underlying topological attributes of these networks. Our results supported that the T1w/T2w ratio brain networks were comprised of small-worldness, an exponentially truncated power-law degree distribution, frontal-parietal hubs and modular organization. Besides, there were significant positive correlations between the network metrics and fluid intelligence. Thus, the T1w/T2w ratio brain networks open a new avenue to understand the human brain and are a necessary supplement for future MRI studies.

  11. Disrupted topology of hippocampal connectivity is associated with short-term antidepressant response in major depressive disorder.

    PubMed

    Gong, Liang; Hou, Zhenghua; Wang, Zan; He, Cancan; Yin, Yingying; Yuan, Yonggui; Zhang, Haisan; Lv, Luxian; Zhang, Hongxing; Xie, Chunming; Zhang, Zhijun

    2018-01-01

    Graph theoretical analyses have identified disrupted functional topological organization across the brain in patients with major depressive disorder (MDD). However, the relationship between brain topology and short-term treatment responses in patients with MDD remains unknown. Sixty-eight patients with MDD and 63 cognitively normal (CN) subjects were recruited at baseline and underwent resting-state functional magnetic resonance imaging scans. Graph theory analysis was used to examine group differences in the whole-brain functional topological properties. The association between altered brain topology and the early antidepressant response was examined. Patients with MDD showed lower normalized clustering coefficients, lower small-worldness scalars and increased nodal efficiencies in the default mode network and decreased nodal efficiencies in basal ganglia and hippocampal networks. In addition, the decreased nodal efficiency in left hippocampus was negatively correlated with depressive severity at baseline and positively correlated with changes in the depressive scores after two weeks of antidepressant treatment. The patients in the present study received different medications. These findings indicated that the altered brain functional topological organization in patients with MDD is associated with the treatment response in the early phase of medication. Therefore, brain topology assessments might be considered a useful and convenient predictor of short-term antidepressant responses. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. An Investigation of the Differences and Similarities between Generated Small-World Networks for Right- and Left-Hand Motor Imageries.

    PubMed

    Zhang, Jiang; Li, Yuyao; Chen, Huafu; Ding, Jurong; Yuan, Zhen

    2016-11-04

    In this study, small-world network analysis was performed to identify the similarities and differences between functional brain networks for right- and left-hand motor imageries (MIs). First, Pearson correlation coefficients among the nodes within the functional brain networks from healthy subjects were calculated. Then, small-world network indicators, including the clustering coefficient, the average path length, the global efficiency, the local efficiency, the average node degree, and the small-world index, were generated for the functional brain networks during both right- and left-hand MIs. We identified large differences in the small-world network indicators between the functional networks during MI and in the random networks. More importantly, the functional brain networks underlying the right- and left-hand MIs exhibited similar small-world properties in terms of the clustering coefficient, the average path length, the global efficiency, and the local efficiency. By contrast, the right- and left-hand MI brain networks showed differences in small-world characteristics, including indicators such as the average node degree and the small-world index. Interestingly, our findings also suggested that the differences in the activity intensity and range, the average node degree, and the small-world index of brain networks between the right- and left-hand MIs were associated with the asymmetry of brain functions.

  13. Modeling and dynamical topology properties of VANET based on complex networks theory

    NASA Astrophysics Data System (ADS)

    Zhang, Hong; Li, Jie

    2015-01-01

    Vehicular Ad hoc Network (VANET) is a special subset of multi-hop Mobile Ad hoc Networks in which vehicles can not only communicate with each other but also with the fixed equipments along the roads through wireless interfaces. Recently, it has been discovered that essential systems in real world share similar properties. When they are regarded as networks, among which the dynamic topology structure of VANET system is an important issue. Many real world networks are actually growing with preferential attachment like Internet, transportation system and telephone network. Those phenomena have brought great possibility in finding a strategy to calibrate and control the topology parameters which can help find VANET topology change regulation to relieve traffic jam, prevent traffic accident and improve traffic safety. VANET is a typical complex network which has its basic characteristics. In this paper, we focus on the macroscopic Vehicle-to-Infrastructure (V2I) and Vehicle-to-Vehicle (V2V) inter-vehicle communication network with complex network theory. In particular, this paper is the first one to propose a method analyzing the topological structure and performance of VANET and present the communications in VANET from a new perspective. Accordingly, we propose degree distribution, clustering coefficient and the short path length of complex network to implement our strategy by numerical example and simulation. All the results demonstrate that VANET shows small world network features and is characterized by a truncated scale-free degree distribution with power-law degree distribution. The average path length of the network is simulated numerically, which indicates that the network shows small-world property and is rarely affected by the randomness. What's more, we carry out extensive simulations of information propagation and mathematically prove the power law property when γ > 2. The results of this study provide useful information for VANET optimization from a

  14. Modeling and dynamical topology properties of VANET based on complex networks theory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Hong; Li, Jie, E-mail: prof.li@foxmail.com

    2015-01-15

    Vehicular Ad hoc Network (VANET) is a special subset of multi-hop Mobile Ad hoc Networks in which vehicles can not only communicate with each other but also with the fixed equipments along the roads through wireless interfaces. Recently, it has been discovered that essential systems in real world share similar properties. When they are regarded as networks, among which the dynamic topology structure of VANET system is an important issue. Many real world networks are actually growing with preferential attachment like Internet, transportation system and telephone network. Those phenomena have brought great possibility in finding a strategy to calibrate andmore » control the topology parameters which can help find VANET topology change regulation to relieve traffic jam, prevent traffic accident and improve traffic safety. VANET is a typical complex network which has its basic characteristics. In this paper, we focus on the macroscopic Vehicle-to-Infrastructure (V2I) and Vehicle-to-Vehicle (V2V) inter-vehicle communication network with complex network theory. In particular, this paper is the first one to propose a method analyzing the topological structure and performance of VANET and present the communications in VANET from a new perspective. Accordingly, we propose degree distribution, clustering coefficient and the short path length of complex network to implement our strategy by numerical example and simulation. All the results demonstrate that VANET shows small world network features and is characterized by a truncated scale-free degree distribution with power-law degree distribution. The average path length of the network is simulated numerically, which indicates that the network shows small-world property and is rarely affected by the randomness. What’s more, we carry out extensive simulations of information propagation and mathematically prove the power law property when γ > 2. The results of this study provide useful information for VANET optimization

  15. Influence of the native topology on the folding barrier for small proteins

    NASA Astrophysics Data System (ADS)

    Prieto, Lidia; Rey, Antonio

    2007-11-01

    The possibility of downhill instead of two-state folding for proteins has been a very controversial topic which arose from recent experimental studies. From the theoretical side, this question has also been accomplished in different ways. Given the experimental observation that a relationship exists between the native structure topology of a protein and the kinetic and thermodynamic properties of its folding process, Gō-type potentials are an appropriate way to approach this problem. In this work, we employ an interaction potential from this family to get a better insight on the topological characteristics of the native state that may somehow determine the presence of a thermodynamic barrier in the folding pathway. The results presented here show that, indeed, the native topology of a small protein has a great influence on its folding behavior, mostly depending on the proportion of local and long range contacts the protein has in its native structure. Furthermore, when all the interactions present contribute in a balanced way, the transition results to be cooperative. Otherwise, the tendency to a downhill folding behavior increases.

  16. Topological Analysis and Gaussian Decision Tree: Effective Representation and Classification of Biosignals of Small Sample Size.

    PubMed

    Zhang, Zhifei; Song, Yang; Cui, Haochen; Wu, Jayne; Schwartz, Fernando; Qi, Hairong

    2017-09-01

    Bucking the trend of big data, in microdevice engineering, small sample size is common, especially when the device is still at the proof-of-concept stage. The small sample size, small interclass variation, and large intraclass variation, have brought biosignal analysis new challenges. Novel representation and classification approaches need to be developed to effectively recognize targets of interests with the absence of a large training set. Moving away from the traditional signal analysis in the spatiotemporal domain, we exploit the biosignal representation in the topological domain that would reveal the intrinsic structure of point clouds generated from the biosignal. Additionally, we propose a Gaussian-based decision tree (GDT), which can efficiently classify the biosignals even when the sample size is extremely small. This study is motivated by the application of mastitis detection using low-voltage alternating current electrokinetics (ACEK) where five categories of bisignals need to be recognized with only two samples in each class. Experimental results demonstrate the robustness of the topological features as well as the advantage of GDT over some conventional classifiers in handling small dataset. Our method reduces the voltage of ACEK to a safe level and still yields high-fidelity results with a short assay time. This paper makes two distinctive contributions to the field of biosignal analysis, including performing signal processing in the topological domain and handling extremely small dataset. Currently, there have been no related works that can efficiently tackle the dilemma between avoiding electrochemical reaction and accelerating assay process using ACEK.

  17. Handedness- and brain size-related efficiency differences in small-world brain networks: a resting-state functional magnetic resonance imaging study.

    PubMed

    Li, Meiling; Wang, Junping; Liu, Feng; Chen, Heng; Lu, Fengmei; Wu, Guorong; Yu, Chunshui; Chen, Huafu

    2015-05-01

    The human brain has been described as a complex network, which integrates information with high efficiency. However, the relationships between the efficiency of human brain functional networks and handedness and brain size remain unclear. Twenty-one left-handed and 32 right-handed healthy subjects underwent a resting-state functional magnetic resonance imaging scan. The whole brain functional networks were constructed by thresholding Pearson correlation matrices of 90 cortical and subcortical regions. Graph theory-based methods were employed to further analyze their topological properties. As expected, all participants demonstrated small-world topology, suggesting a highly efficient topological structure. Furthermore, we found that smaller brains showed higher local efficiency, whereas larger brains showed higher global efficiency, reflecting a suitable efficiency balance between local specialization and global integration of brain functional activity. Compared with right-handers, significant alterations in nodal efficiency were revealed in left-handers, involving the anterior and median cingulate gyrus, middle temporal gyrus, angular gyrus, and amygdala. Our findings indicated that the functional network organization in the human brain was associated with handedness and brain size.

  18. Small Modifications to Network Topology Can Induce Stochastic Bistable Spiking Dynamics in a Balanced Cortical Model

    PubMed Central

    McDonnell, Mark D.; Ward, Lawrence M.

    2014-01-01

    Abstract Directed random graph models frequently are used successfully in modeling the population dynamics of networks of cortical neurons connected by chemical synapses. Experimental results consistently reveal that neuronal network topology is complex, however, in the sense that it differs statistically from a random network, and differs for classes of neurons that are physiologically different. This suggests that complex network models whose subnetworks have distinct topological structure may be a useful, and more biologically realistic, alternative to random networks. Here we demonstrate that the balanced excitation and inhibition frequently observed in small cortical regions can transiently disappear in otherwise standard neuronal-scale models of fluctuation-driven dynamics, solely because the random network topology was replaced by a complex clustered one, whilst not changing the in-degree of any neurons. In this network, a small subset of cells whose inhibition comes only from outside their local cluster are the cause of bistable population dynamics, where different clusters of these cells irregularly switch back and forth from a sparsely firing state to a highly active state. Transitions to the highly active state occur when a cluster of these cells spikes sufficiently often to cause strong unbalanced positive feedback to each other. Transitions back to the sparsely firing state rely on occasional large fluctuations in the amount of non-local inhibition received. Neurons in the model are homogeneous in their intrinsic dynamics and in-degrees, but differ in the abundance of various directed feedback motifs in which they participate. Our findings suggest that (i) models and simulations should take into account complex structure that varies for neuron and synapse classes; (ii) differences in the dynamics of neurons with similar intrinsic properties may be caused by their membership in distinctive local networks; (iii) it is important to identify neurons that

  19. Why is the World four-dimensional? Hermann Weyl’s 1955 argument and the topology of causation

    NASA Astrophysics Data System (ADS)

    De Bianchi, Silvia

    2017-08-01

    This paper approaches the question of space dimensionality by discussing a neglected argument proposed by Hermann Weyl in 1955. In Why is the World Four-Dimensional? (1955), Weyl offered a different argument from the one generally attributed to him and presented in Raum-Zeit-Materie. In the first sections of the paper, this new argument and its features are spelled-out, and in the last section, I shall develop some useful remarks on the concept of topology of causation that can still inform our reflection on the dimensionality of the world.

  20. INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY: Spiral Wave in Small-World Networks of Hodgkin-Huxley Neurons

    NASA Astrophysics Data System (ADS)

    Ma, Jun; Yang, Li-Jian; Wu, Ying; Zhang, Cai-Rong

    2010-09-01

    The effect of small-world connection and noise on the formation and transition of spiral wave in the networks of Hodgkin-Huxley neurons are investigated in detail. Some interesting results are found in our numerical studies. i) The quiescent neurons are activated to propagate electric signal to others by generating and developing spiral wave from spiral seed in small area. ii) A statistical factor is defined to describe the collective properties and phase transition induced by the topology of networks and noise. iii) Stable rotating spiral wave can be generated and keeps robust when the rewiring probability is below certain threshold, otherwise, spiral wave can not be developed from the spiral seed and spiral wave breakup occurs for a stable rotating spiral wave. iv) Gaussian white noise is introduced on the membrane of neurons to study the noise-induced phase transition on spiral wave in small-world networks of neurons. It is confirmed that Gaussian white noise plays active role in supporting and developing spiral wave in the networks of neurons, and appearance of smaller factor of synchronization indicates high possibility to induce spiral wave.

  1. Antibiotic discovery throughout the Small World Initiative: A molecular strategy to identify biosynthetic gene clusters involved in antagonistic activity.

    PubMed

    Davis, Elizabeth; Sloan, Tyler; Aurelius, Krista; Barbour, Angela; Bodey, Elijah; Clark, Brigette; Dennis, Celeste; Drown, Rachel; Fleming, Megan; Humbert, Allison; Glasgo, Elizabeth; Kerns, Trent; Lingro, Kelly; McMillin, MacKenzie; Meyer, Aaron; Pope, Breanna; Stalevicz, April; Steffen, Brittney; Steindl, Austin; Williams, Carolyn; Wimberley, Carmen; Zenas, Robert; Butela, Kristen; Wildschutte, Hans

    2017-06-01

    The emergence of bacterial pathogens resistant to all known antibiotics is a global health crisis. Adding to this problem is that major pharmaceutical companies have shifted away from antibiotic discovery due to low profitability. As a result, the pipeline of new antibiotics is essentially dry and many bacteria now resist the effects of most commonly used drugs. To address this global health concern, citizen science through the Small World Initiative (SWI) was formed in 2012. As part of SWI, students isolate bacteria from their local environments, characterize the strains, and assay for antibiotic production. During the 2015 fall semester at Bowling Green State University, students isolated 77 soil-derived bacteria and genetically characterized strains using the 16S rRNA gene, identified strains exhibiting antagonistic activity, and performed an expanded SWI workflow using transposon mutagenesis to identify a biosynthetic gene cluster involved in toxigenic compound production. We identified one mutant with loss of antagonistic activity and through subsequent whole-genome sequencing and linker-mediated PCR identified a 24.9 kb biosynthetic gene locus likely involved in inhibitory activity in that mutant. Further assessment against human pathogens demonstrated the inhibition of Bacillus cereus, Listeria monocytogenes, and methicillin-resistant Staphylococcus aureus in the presence of this compound, thus supporting our molecular strategy as an effective research pipeline for SWI antibiotic discovery and genetic characterization. © 2017 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

  2. Characterization of topological structure on complex networks.

    PubMed

    Nakamura, Ikuo

    2003-10-01

    Characterizing the topological structure of complex networks is a significant problem especially from the viewpoint of data mining on the World Wide Web. "Page rank" used in the commercial search engine Google is such a measure of authority to rank all the nodes matching a given query. We have investigated the page-rank distribution of the real Web and a growing network model, both of which have directed links and exhibit a power law distributions of in-degree (the number of incoming links to the node) and out-degree (the number of outgoing links from the node), respectively. We find a concentration of page rank on a small number of nodes and low page rank on high degree regimes in the real Web, which can be explained by topological properties of the network, e.g., network motifs, and connectivities of nearest neighbors.

  3. Using dynamics to identify network topology

    NASA Astrophysics Data System (ADS)

    Rahi, Sahand Jamal; Tsaneva-Atanasova, Krasimira

    2013-03-01

    To elucidate the topology of a signaling pathway, generally, experimentalists manipulate a cell's molecular architecture, for example, by knocking out genes. Molecular biology techniques, though, are not only invasive and labor-intensive, they have also often been eluded by the complexity of biological networks, e.g., in the case of the gonadotropin-releasing hormone (GnRH) system. Inspired by the rapidly accumulating examples of oscillatory signaling in biology, we explored whether such dynamical stimuli can be used to discriminate different topologies of adaptive pathways, which are ubiquitous in biology. Responses to static inputs are nearly indistinguishable given strong measurement noise. Sine function stimuli, widely used in physics, are difficult to implement in standard microfluidics or optogenetics set-ups and do not simplify the mathematical analysis because of the nonlinearities in these systems. With periodic on-off pulses, which can be easily produced, however, simple adaptive circuit motifs and detailed models from the literature robustly reveal distinct output characteristics, which manifest in how the period of maximal output varies with pulse width. Our calculations provide a framework for using existing methods to discover difficult to reveal mechanisms. Furthermore, our results constrain the possible design principles of the presumed frequency decoders in biological systems where pulsatile signaling has recently been discovered.

  4. A Single Session of rTMS Enhances Small-Worldness in Writer's Cramp: Evidence from Simultaneous EEG-fMRI Multi-Modal Brain Graph.

    PubMed

    Bharath, Rose D; Panda, Rajanikant; Reddam, Venkateswara Reddy; Bhaskar, M V; Gohel, Suril; Bhardwaj, Sujas; Prajapati, Arvind; Pal, Pramod Kumar

    2017-01-01

    Background and Purpose : Repetitive transcranial magnetic stimulation (rTMS) induces widespread changes in brain connectivity. As the network topology differences induced by a single session of rTMS are less known we undertook this study to ascertain whether the network alterations had a small-world morphology using multi-modal graph theory analysis of simultaneous EEG-fMRI. Method : Simultaneous EEG-fMRI was acquired in duplicate before (R1) and after (R2) a single session of rTMS in 14 patients with Writer's Cramp (WC). Whole brain neuronal and hemodynamic network connectivity were explored using the graph theory measures and clustering coefficient, path length and small-world index were calculated for EEG and resting state fMRI (rsfMRI). Multi-modal graph theory analysis was used to evaluate the correlation of EEG and fMRI clustering coefficients. Result : A single session of rTMS was found to increase the clustering coefficient and small-worldness significantly in both EEG and fMRI ( p < 0.05). Multi-modal graph theory analysis revealed significant modulations in the fronto-parietal regions immediately after rTMS. The rsfMRI revealed additional modulations in several deep brain regions including cerebellum, insula and medial frontal lobe. Conclusion : Multi-modal graph theory analysis of simultaneous EEG-fMRI can supplement motor physiology methods in understanding the neurobiology of rTMS in vivo . Coinciding evidence from EEG and rsfMRI reports small-world morphology for the acute phase network hyper-connectivity indicating changes ensuing low-frequency rTMS is probably not "noise".

  5. A Comparison of Geographic Information Systems, Complex Networks, and Other Models for Analyzing Transportation Network Topologies

    NASA Technical Reports Server (NTRS)

    Alexandrov, Natalia (Technical Monitor); Kuby, Michael; Tierney, Sean; Roberts, Tyler; Upchurch, Christopher

    2005-01-01

    This report reviews six classes of models that are used for studying transportation network topologies. The report is motivated by two main questions. First, what can the "new science" of complex networks (scale-free, small-world networks) contribute to our understanding of transport network structure, compared to more traditional methods? Second, how can geographic information systems (GIS) contribute to studying transport networks? The report defines terms that can be used to classify different kinds of models by their function, composition, mechanism, spatial and temporal dimensions, certainty, linearity, and resolution. Six broad classes of models for analyzing transport network topologies are then explored: GIS; static graph theory; complex networks; mathematical programming; simulation; and agent-based modeling. Each class of models is defined and classified according to the attributes introduced earlier. The paper identifies some typical types of research questions about network structure that have been addressed by each class of model in the literature.

  6. Small Worlds Week: Raising Curiosity and Contributing to STEM

    NASA Astrophysics Data System (ADS)

    Ng, C.; Mayo, L.; Stephenson, B. E.; Keck, A.; Cline, T. D.; Lewis, E. M.

    2015-12-01

    Dwarf planets, comets, asteroids, and icy moons took center stage in the years 2014-2015 as multiple spacecraft (New Horizons, Dawn, Rosetta, Cassini) and ground-based observing campaigns observed these small and yet amazing celestial bodies. Just prior to the historic New Horizons encounter with the Pluto system, NASA celebrated Small Worlds Week (July 6-10) as a fully online program to highlight small worlds mission discoveries. Small Worlds Week leveraged the infrastructure of Sun-Earth Days that included a robust web design, exemplary education materials, hands-on fun activities, multimedia resources, science and career highlights, and a culminating event. Each day from July 6-9, a new class of solar system small worlds was featured on the website: Monday-comets, Tuesday-asteroids, Wednesday-icy moons, and Thursday-dwarf planets. Then on Friday, July 10, nine scientists from Goddard Space Flight Center, Jet Propulsion Laboratory, Naval Research Laboratory, and Lunar and Planetary Institute gathered online for four hours to answer questions from the public via Facebook and Twitter. Throughout the afternoon the scientists worked closely with a social media expert and several summer interns to reply to inquirers and to archive their chats. By all accounts, Small Worlds Week was a huge success. The group plans to improve and replicate the program during the school year with a more classroom focus, and then to build and extend the program to be held every year. For more information, visit http:// sunearthday.nasa.gov or catch us on Twitter, #nasasww.

  7. Hemisphere- and gender-related differences in small-world brain networks: a resting-state functional MRI study.

    PubMed

    Tian, Lixia; Wang, Jinhui; Yan, Chaogan; He, Yong

    2011-01-01

    We employed resting-state functional MRI (R-fMRI) to investigate hemisphere- and gender-related differences in the topological organization of human brain functional networks. Brain networks were first constructed by measuring inter-regional temporal correlations of R-fMRI data within each hemisphere in 86 young, healthy, right-handed adults (38 males and 48 females) followed by a graph-theory analysis. The hemispheric networks exhibit small-world attributes (high clustering and short paths) that are compatible with previous results in the whole-brain functional networks. Furthermore, we found that compared with females, males have a higher normalized clustering coefficient in the right hemispheric network but a lower clustering coefficient in the left hemispheric network, suggesting a gender-hemisphere interaction. Moreover, we observed significant hemisphere-related differences in the regional nodal characteristics in various brain regions, such as the frontal and occipital regions (leftward asymmetry) and the temporal regions (rightward asymmetry), findings that are consistent with previous studies of brain structural and functional asymmetries. Together, our results suggest that the topological organization of human brain functional networks is associated with gender and hemispheres, and they provide insights into the understanding of functional substrates underlying individual differences in behaviors and cognition. Copyright © 2010 Elsevier Inc. All rights reserved.

  8. Exploring the story, science, and adventure of small worlds

    NASA Astrophysics Data System (ADS)

    Swann, J. L.; Elkins-Tanton, L. T.; Anbar, A. D.; Klug Boonstra, S.; Tamer, A. J.; Mead, C.; Hunsley, D.

    2017-12-01

    Small worlds are a strategic focus at NASA, reflected by missions such as Osiris Rex and Psyche among others. The Infiniscope project, with funding from NASA SMD, is building on this scientific and public interest to teach formal and informal learners about asteroids and other small worlds. The digital learning experience, "Where are the small worlds?", and future Infiniscope experiences, incorporate a design theory that we describe as "education through exploration" (ETX) which is provided through an adaptive e-learning platform. This design ensures that learners actively engage in exploration and discovery, while receiving targeted feedback to push through challenges. To ensure that this and future experiences reach and meet the needs of as many educators as possible, Infiniscope includes a digital teaching network to host the experiences and support the reuse and adaptation of digital resources in new lessons. "Where are the small worlds?" puts learners in an interactive simulation of the solar system and provides a mission structure in which they hunt for "astrocaches" on near earth objects, main belt asteroids, and Kuiper-belt objects. These activities allow the learner to discover the locations of the small worlds in the solar system and develop an intuitive understanding for the relative motion of objects at various distances from the Sun. The experience is NGSS-aligned and accompanied by a lesson plan for integration into the classroom. In testing with more than 500 middle-school students, 83% of participants said they wanted to do more experiences like "Where are the small worlds?" They also found the experience both "fun" and "interesting" while being moderately difficult. "Where are the small worlds?" is one of many visualizations and lessons that is available within the Infiniscope teaching network. The network already has hundreds of members and is expected to grow in both numbers and engagement over time. Currently, educators can search and use pre

  9. Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.

    PubMed

    Amaral, Paulo P; Leonardi, Tommaso; Han, Namshik; Viré, Emmanuelle; Gascoigne, Dennis K; Arias-Carrasco, Raúl; Büscher, Magdalena; Pandolfini, Luca; Zhang, Anda; Pluchino, Stefano; Maracaja-Coutinho, Vinicius; Nakaya, Helder I; Hemberg, Martin; Shiekhattar, Ramin; Enright, Anton J; Kouzarides, Tony

    2018-03-15

    The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly due to their low sequence conservation and lack of identified shared properties. Here we consider promoter conservation and positional conservation as indicators of functional commonality. We identify 665 conserved lncRNA promoters in mouse and human that are preserved in genomic position relative to orthologous coding genes. These positionally conserved lncRNA genes are primarily associated with developmental transcription factor loci with which they are coexpressed in a tissue-specific manner. Over half of positionally conserved RNAs in this set are linked to chromatin organization structures, overlapping binding sites for the CTCF chromatin organiser and located at chromatin loop anchor points and borders of topologically associating domains (TADs). We define these RNAs as topological anchor point RNAs (tapRNAs). Characterization of these noncoding RNAs and their associated coding genes shows that they are functionally connected: they regulate each other's expression and influence the metastatic phenotype of cancer cells in vitro in a similar fashion. Furthermore, we find that tapRNAs contain conserved sequence domains that are enriched in motifs for zinc finger domain-containing RNA-binding proteins and transcription factors, whose binding sites are found mutated in cancers. This work leverages positional conservation to identify lncRNAs with potential importance in genome organization, development and disease. The evidence that many developmental transcription factors are physically and functionally connected to lncRNAs represents an exciting stepping-stone to further our understanding of genome regulation.

  10. Stochastic resonance in the majority vote model on regular and small-world lattices

    NASA Astrophysics Data System (ADS)

    Krawiecki, A.

    2017-11-01

    The majority vote model with two states on regular and small-world networks is considered under the influence of periodic driving. Monte Carlo simulations show that the time-dependent magnetization, playing the role of the output signal, exhibits maximum periodicity at nonzero values of the internal noise parameter q, which is manifested as the occurrence of the maximum of the spectral power amplification; the location of the maximum depends in a nontrivial way on the amplitude and frequency of the periodic driving as well as on the network topology. This indicates the appearance of stochastic resonance in the system as a function of the intensity of the internal noise. Besides, for low frequencies and for certain narrow ranges of the amplitudes of the periodic driving double maxima of the spectral power amplification as a function of q occur, i.e., stochastic multiresonance appears. The above-mentioned results quantitatively agree with those obtained from numerical simulations of the mean-field equations for the time-dependent magnetization. In contrast, analytic solutions for the spectral power amplification obtained from the latter equations using the linear response approximation deviate significanlty from the numerical results since the effect of the periodic driving on the system is not small even for vanishing amplitude.

  11. Vortex line topology during vortex tube reconnection

    NASA Astrophysics Data System (ADS)

    McGavin, P.; Pontin, D. I.

    2018-05-01

    This paper addresses reconnection of vortex tubes, with particular focus on the topology of the vortex lines (field lines of the vorticity). This analysis of vortex line topology reveals key features of the reconnection process, such as the generation of many small flux rings, formed when reconnection occurs in multiple locations in the vortex sheet between the tubes. Consideration of three-dimensional reconnection principles leads to a robust measurement of the reconnection rate, even once instabilities break the symmetry. It also allows us to identify internal reconnection of vortex lines within the individual vortex tubes. Finally, the introduction of a third vortex tube is shown to render the vortex reconnection process fully three-dimensional, leading to a fundamental change in the topological structure of the process. An additional interesting feature is the generation of vorticity null points.

  12. Big World of Small Neutrinos

    Science.gov Websites

    electron neutrino, muon neutrino, or tau neutrino. The three different neutrinos are complemented by anti of the neutrinos we detect will look different (have a different flavor) compared to the time they Big World of Small Neutrinos Neutrinos will find you! Fig 1: Hubble image of the deep field

  13. International migration network: Topology and modeling

    NASA Astrophysics Data System (ADS)

    Fagiolo, Giorgio; Mastrorillo, Marina

    2013-07-01

    This paper studies international migration from a complex-network perspective. We define the international migration network (IMN) as the weighted-directed graph where nodes are world countries and links account for the stock of migrants originated in a given country and living in another country at a given point in time. We characterize the binary and weighted architecture of the network and its evolution over time in the period 1960-2000. We find that the IMN is organized around a modular structure with a small-world binary pattern displaying disassortativity and high clustering, with power-law distributed weighted-network statistics. We also show that a parsimonious gravity model of migration can account for most of observed IMN topological structure. Overall, our results suggest that socioeconomic, geographical, and political factors are more important than local-network properties in shaping the structure of the IMN.

  14. International migration network: topology and modeling.

    PubMed

    Fagiolo, Giorgio; Mastrorillo, Marina

    2013-07-01

    This paper studies international migration from a complex-network perspective. We define the international migration network (IMN) as the weighted-directed graph where nodes are world countries and links account for the stock of migrants originated in a given country and living in another country at a given point in time. We characterize the binary and weighted architecture of the network and its evolution over time in the period 1960-2000. We find that the IMN is organized around a modular structure with a small-world binary pattern displaying disassortativity and high clustering, with power-law distributed weighted-network statistics. We also show that a parsimonious gravity model of migration can account for most of observed IMN topological structure. Overall, our results suggest that socioeconomic, geographical, and political factors are more important than local-network properties in shaping the structure of the IMN.

  15. Revealing the structure of the world airline network

    PubMed Central

    Verma, T.; Araújo, N. A. M.; Herrmann, H. J.

    2014-01-01

    Resilience of most critical infrastructures against failure of elements that appear insignificant is usually taken for granted. The World Airline Network (WAN) is an infrastructure that reduces the geographical gap between societies, both small and large, and brings forth economic gains. With the extensive use of a publicly maintained data set that contains information about airports and alternative connections between these airports, we empirically reveal that the WAN is a redundant and resilient network for long distance air travel, but otherwise breaks down completely due to removal of short and apparently insignificant connections. These short range connections with moderate number of passengers and alternate flights are the connections that keep remote parts of the world accessible. It is surprising, insofar as there exists a highly resilient and strongly connected core consisting of a small fraction of airports (around 2.3%) together with an extremely fragile star-like periphery. Yet, in spite of their relevance, more than 90% of the world airports are still interconnected upon removal of this core. With standard and unconventional removal measures we compare both empirical and topological perceptions for the fragmentation of the world. We identify how the WAN is organized into different classes of clusters based on the physical proximity of airports and analyze the consequence of this fragmentation. PMID:25005934

  16. Cosmic Topology

    NASA Astrophysics Data System (ADS)

    Luminet, Jean-Pierre

    2015-08-01

    Cosmic Topology is the name given to the study of the overall shape of the universe, which involves both global topological features and more local geometrical properties such as curvature. Whether space is finite or infinite, simply-connected or multi-connected like a torus, smaller or greater than the portion of the universe that we can directly observe, are questions that refer to topology rather than curvature. A striking feature of some relativistic, multi-connected "small" universe models is to create multiples images of faraway cosmic sources. While the most recent cosmological data fit the simplest model of a zero-curvature, infinite space model, they are also consistent with compact topologies of the three homogeneous and isotropic geometries of constant curvature, such as, for instance, the spherical Poincaré Dodecahedral Space, the flat hypertorus or the hyperbolic Picard horn. After a "dark age" period, the field of Cosmic Topology has recently become one of the major concerns in cosmology, not only for theorists but also for observational astronomers, leaving open a number of unsolved issues.

  17. Small-world behaviour in a system of mobile elements

    NASA Astrophysics Data System (ADS)

    Manrubia, S. C.; Delgado, J.; Luque, B.

    2001-03-01

    We analyze the propagation of activity in a system of mobile automata. A number ρLd of elements move as random walkers on a lattice of dimension d, while with a small probability p they can jump to any empty site in the system. We show that this system behaves as a Dynamic Small World (DSW) and present analytic and numerical results for several quantities. Our analysis shows that the persistence time T* (equivalent to the persistence size L* of small-world networks) scales as T* ~ (ρp)-τ, with τ = 1/(d + 1).

  18. Disrupted Small-World Networks in Schizophrenia

    ERIC Educational Resources Information Center

    Liu, Yong; Liang, Meng; Zhou, Yuan; He, Yong; Hao, Yihui; Song, Ming; Yu, Chunshui; Liu, Haihong; Liu, Zhening; Jiang, Tianzi

    2008-01-01

    The human brain has been described as a large, sparse, complex network characterized by efficient small-world properties, which assure that the brain generates and integrates information with high efficiency. Many previous neuroimaging studies have provided consistent evidence of "dysfunctional connectivity" among the brain regions in…

  19. Hg-Based Epitaxial Materials for Topological Insulators

    DTIC Science & Technology

    2014-07-01

    Research Laboratory for investigation of properties. 15. SUBJECT TERMS EOARD, topological insulator , diluted magnetic ...topological superconductors and spintronics to quantum computation (e.g. see C.L.Kane and J.E.Moore "Topological Insulators " Physics World (2011) 24...tetradymite semiconductors Bi2Te3, Bi2Se3, and Sb2Te3 which form magnetically ordered insulators when doped with transition metal elements Cr or Fe (Rui Yu et

  20. On the relation between the small world structure and scientific activities.

    PubMed

    Ebadi, Ashkan; Schiffauerova, Andrea

    2015-01-01

    The modern science has become more complex and interdisciplinary in its nature which might encourage researchers to be more collaborative and get engaged in larger collaboration networks. Various aspects of collaboration networks have been examined so far to detect the most determinant factors in knowledge creation and scientific production. One of the network structures that recently attracted much theoretical attention is called small world. It has been suggested that small world can improve the information transmission among the network actors. In this paper, using the data on 12 periods of journal publications of Canadian researchers in natural sciences and engineering, the co-authorship networks of the researchers are created. Through measuring small world indicators, the small worldiness of the mentioned network and its relation with researchers' productivity, quality of their publications, and scientific team size are assessed. Our results show that the examined co-authorship network strictly exhibits the small world properties. In addition, it is suggested that in a small world network researchers expand their team size through getting connected to other experts of the field. This team size expansion may result in higher productivity of the whole team as a result of getting access to new resources, benefitting from the internal referring, and exchanging ideas among the team members. Moreover, although small world network is positively correlated with the quality of the articles in terms of both citation count and journal impact factor, it is negatively related with the average productivity of researchers in terms of the number of their publications.

  1. On the Relation between the Small World Structure and Scientific Activities

    PubMed Central

    Ebadi, Ashkan; Schiffauerova, Andrea

    2015-01-01

    The modern science has become more complex and interdisciplinary in its nature which might encourage researchers to be more collaborative and get engaged in larger collaboration networks. Various aspects of collaboration networks have been examined so far to detect the most determinant factors in knowledge creation and scientific production. One of the network structures that recently attracted much theoretical attention is called small world. It has been suggested that small world can improve the information transmission among the network actors. In this paper, using the data on 12 periods of journal publications of Canadian researchers in natural sciences and engineering, the co-authorship networks of the researchers are created. Through measuring small world indicators, the small worldiness of the mentioned network and its relation with researchers’ productivity, quality of their publications, and scientific team size are assessed. Our results show that the examined co-authorship network strictly exhibits the small world properties. In addition, it is suggested that in a small world network researchers expand their team size through getting connected to other experts of the field. This team size expansion may result in higher productivity of the whole team as a result of getting access to new resources, benefitting from the internal referring, and exchanging ideas among the team members. Moreover, although small world network is positively correlated with the quality of the articles in terms of both citation count and journal impact factor, it is negatively related with the average productivity of researchers in terms of the number of their publications. PMID:25780922

  2. Walking and Talking Geography: A Small-World Approach

    ERIC Educational Resources Information Center

    Fertig, Gary; Silverman, Rick

    2007-01-01

    When teaching geography to students in the primary grades, teachers should provide firsthand experiences that young children need to make meaningful sense of their world. David Sobel, author of "Mapmaking with Children: Sense of Place Education for the Elementary Years," suggests that teachers in the early grades adopt a small-world approach to…

  3. Hidden landscapes in thin film topological insulators: between order and disorder, 2D and 3D, normal and topological phases

    NASA Astrophysics Data System (ADS)

    Oh, Seongshik

    Topological insulator (TI) is one of the rare systems in the history of condensed matter physics that is initiated by theories and followed by experiments. Although this theory-driven advance helped move the field quite fast despite its short history, apparently there exist significant gaps between theories and experiments. Many of these discrepancies originate from the very fact that the worlds readily accessible to theories are often far from the real worlds that are available in experiments. For example, the very paradigm of topological protection of the surface states on Z2 TIs such as Bi2Se3, Bi2Te3, Sb2Te3, etc, is in fact valid only if the sample size is infinite and the crystal momentum is well-defined in all three dimensions. On the other hand, many widely studied forms of TIs such as thin films and nano-wires have significant confinement in one or more of the dimensions with varying level of disorders. In other words, many of the real world topological systems have some important parameters that are not readily captured by theories, and thus it is often questionable how far the topological theories are valid to real systems. Interestingly, it turns out that this very uncertainty of the theories provides additional control knobs that allow us to explore hidden topological territories. In this talk, I will discuss how these additional knobs in thin film topological insulators reveal surprising, at times beautiful, landscapes at the boundaries between order and disorder, 2D and 3D, normal and topological phases. This work is supported by Gordon and Betty Moore Foundation's EPiQS Initiative (GBMF4418).

  4. Spectrum-Based and Collaborative Network Topology Analysis and Visualization

    ERIC Educational Resources Information Center

    Hu, Xianlin

    2013-01-01

    Networks are of significant importance in many application domains, such as World Wide Web and social networks, which often embed rich topological information. Since network topology captures the organization of network nodes and links, studying network topology is very important to network analysis. In this dissertation, we study networks by…

  5. Small-world human brain networks: Perspectives and challenges.

    PubMed

    Liao, Xuhong; Vasilakos, Athanasios V; He, Yong

    2017-06-01

    Modelling the human brain as a complex network has provided a powerful mathematical framework to characterize the structural and functional architectures of the brain. In the past decade, the combination of non-invasive neuroimaging techniques and graph theoretical approaches enable us to map human structural and functional connectivity patterns (i.e., connectome) at the macroscopic level. One of the most influential findings is that human brain networks exhibit prominent small-world organization. Such a network architecture in the human brain facilitates efficient information segregation and integration at low wiring and energy costs, which presumably results from natural selection under the pressure of a cost-efficiency balance. Moreover, the small-world organization undergoes continuous changes during normal development and ageing and exhibits dramatic alterations in neurological and psychiatric disorders. In this review, we survey recent advances regarding the small-world architecture in human brain networks and highlight the potential implications and applications in multidisciplinary fields, including cognitive neuroscience, medicine and engineering. Finally, we highlight several challenging issues and areas for future research in this rapidly growing field. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Microscopic Spin Model for the STOCK Market with Attractor Bubbling on Regular and Small-World Lattices

    NASA Astrophysics Data System (ADS)

    Krawiecki, A.

    A multi-agent spin model for changes of prices in the stock market based on the Ising-like cellular automaton with interactions between traders randomly varying in time is investigated by means of Monte Carlo simulations. The structure of interactions has topology of a small-world network obtained from regular two-dimensional square lattices with various coordination numbers by randomly cutting and rewiring edges. Simulations of the model on regular lattices do not yield time series of logarithmic price returns with statistical properties comparable with the empirical ones. In contrast, in the case of networks with a certain degree of randomness for a wide range of parameters the time series of the logarithmic price returns exhibit intermittent bursting typical of volatility clustering. Also the tails of distributions of returns obey a power scaling law with exponents comparable to those obtained from the empirical data.

  7. Modeling Epidemics with Dynamic Small-World Networks

    NASA Astrophysics Data System (ADS)

    Kaski, Kimmo; Saramäki, Jari

    2005-06-01

    In this presentation a minimal model for describing the spreading of an infectious disease, such as influenza, is discussed. Here it is assumed that spreading takes place on a dynamic small-world network comprising short- and long-range infection events. Approximate equations for the epidemic threshold as well as the spreading dynamics are derived and they agree well with numerical discrete time-step simulations. Also the dependence of the epidemic saturation time on the initial conditions is analysed and a comparison with real-world data is made.

  8. Percolation and epidemics in a two-dimensional small world

    NASA Astrophysics Data System (ADS)

    Newman, M. E.; Jensen, I.; Ziff, R. M.

    2002-02-01

    Percolation on two-dimensional small-world networks has been proposed as a model for the spread of plant diseases. In this paper we give an analytic solution of this model using a combination of generating function methods and high-order series expansion. Our solution gives accurate predictions for quantities such as the position of the percolation threshold and the typical size of disease outbreaks as a function of the density of ``shortcuts'' in the small-world network. Our results agree with scaling hypotheses and numerical simulations for the same model.

  9. Topological X-Rays Revisited

    ERIC Educational Resources Information Center

    Lynch, Mark

    2012-01-01

    We continue our study of topological X-rays begun in Lynch ["Topological X-rays and MRI's," iJMEST 33(3) (2002), pp. 389-392]. We modify our definition of a topological magnetic resonance imaging and give an affirmative answer to the question posed there: Can we identify a closed set in a box by defining X-rays to probe the interior and without…

  10. Topological phonon modes in filamentary structures

    NASA Astrophysics Data System (ADS)

    Berg, Nina; Joel, Kira; Koolyk, Miriam; Prodan, Emil

    2011-02-01

    This work describes a class of topological phonon modes, that is, mechanical vibrations localized at the edges of special structures that are robust against the deformations of the structures. A class of topological phonons was recently found in two-dimensional structures similar to that of microtubules. The present work introduces another class of topological phonons, this time occurring in quasi-one-dimensional filamentary structures with inversion symmetry. The phenomenon is exemplified using a structure inspired from that of actin microfilaments, present in most live cells. The system discussed here is probably the simplest structure that supports topological phonon modes, a fact that allows detailed analysis in both time and frequency domains. We advance the hypothesis that the topological phonon modes are ubiquitous in the biological world and that living organisms make use of them during various processes.

  11. Small-world bias of correlation networks: From brain to climate

    NASA Astrophysics Data System (ADS)

    Hlinka, Jaroslav; Hartman, David; Jajcay, Nikola; Tomeček, David; Tintěra, Jaroslav; Paluš, Milan

    2017-03-01

    Complex systems are commonly characterized by the properties of their graph representation. Dynamical complex systems are then typically represented by a graph of temporal dependencies between time series of state variables of their subunits. It has been shown recently that graphs constructed in this way tend to have relatively clustered structure, potentially leading to spurious detection of small-world properties even in the case of systems with no or randomly distributed true interactions. However, the strength of this bias depends heavily on a range of parameters and its relevance for real-world data has not yet been established. In this work, we assess the relevance of the bias using two examples of multivariate time series recorded in natural complex systems. The first is the time series of local brain activity as measured by functional magnetic resonance imaging in resting healthy human subjects, and the second is the time series of average monthly surface air temperature coming from a large reanalysis of climatological data over the period 1948-2012. In both cases, the clustering in the thresholded correlation graph is substantially higher compared with a realization of a density-matched random graph, while the shortest paths are relatively short, showing thus distinguishing features of small-world structure. However, comparable or even stronger small-world properties were reproduced in correlation graphs of model processes with randomly scrambled interconnections. This suggests that the small-world properties of the correlation matrices of these real-world systems indeed do not reflect genuinely the properties of the underlying interaction structure, but rather result from the inherent properties of correlation matrix.

  12. Small-world bias of correlation networks: From brain to climate.

    PubMed

    Hlinka, Jaroslav; Hartman, David; Jajcay, Nikola; Tomeček, David; Tintěra, Jaroslav; Paluš, Milan

    2017-03-01

    Complex systems are commonly characterized by the properties of their graph representation. Dynamical complex systems are then typically represented by a graph of temporal dependencies between time series of state variables of their subunits. It has been shown recently that graphs constructed in this way tend to have relatively clustered structure, potentially leading to spurious detection of small-world properties even in the case of systems with no or randomly distributed true interactions. However, the strength of this bias depends heavily on a range of parameters and its relevance for real-world data has not yet been established. In this work, we assess the relevance of the bias using two examples of multivariate time series recorded in natural complex systems. The first is the time series of local brain activity as measured by functional magnetic resonance imaging in resting healthy human subjects, and the second is the time series of average monthly surface air temperature coming from a large reanalysis of climatological data over the period 1948-2012. In both cases, the clustering in the thresholded correlation graph is substantially higher compared with a realization of a density-matched random graph, while the shortest paths are relatively short, showing thus distinguishing features of small-world structure. However, comparable or even stronger small-world properties were reproduced in correlation graphs of model processes with randomly scrambled interconnections. This suggests that the small-world properties of the correlation matrices of these real-world systems indeed do not reflect genuinely the properties of the underlying interaction structure, but rather result from the inherent properties of correlation matrix.

  13. SmallWorld Behavior of the Worldwide Active Volcanoes Network: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Spata, A.; Bonforte, A.; Nunnari, G.; Puglisi, G.

    2009-12-01

    We propose a preliminary complex networks based approach in order to model and characterize volcanoes activity correlation observed on a planetary scale over the last two thousand years. Worldwide volcanic activity is in fact related to the general plate tectonics that locally drives the faults activity, that in turn controls the magma upraise beneath the volcanoes. To find correlations among different volcanoes could indicate a common underlying mechanism driving their activity and could help us interpreting the deeper common dynamics controlling their unrest. All the first evidences found testing the procedure, suggest the suitability of this analysis to investigate global volcanism related to plate tectonics. The first correlations found, in fact, indicate that an underlying common large-scale dynamics seems to drive volcanic activity at least around the Pacific plate, where it collides and subduces beneath American, Eurasian and Australian plates. From this still preliminary analysis, also more complex relationships among volcanoes lying on different tectonic margins have been found, suggesting some more complex interrelationships between different plates. The understanding of eventually detected correlations could be also used to further implement warning systems, relating the unrest probabilities of a specific volcano also to the ongoing activity to the correlated ones. Our preliminary results suggest that, as for other many physical and biological systems, an underlying organizing principle of planetary volcanoes activity might exist and it could be a small-world principle. In fact we found that, from a topological perspective, volcanoes correlations are characterized by the typical features of small-world network: a high clustering coefficient and a low characteristic path length. These features confirm that global volcanoes activity is characterized by both short and long-range correlations. We stress here the fact that numerical simulation carried out in

  14. Epidemics in small world networks

    NASA Astrophysics Data System (ADS)

    Telo da Gama, M. M.; Nunes, A.

    2006-03-01

    For many infectious diseases, a small-world network on an underlying regular lattice is a suitable simplified model for the contact structure of the host population. It is well known that the contact network, described in this setting by a single parameter, the small-world parameter p, plays an important role both in the short term and in the long term dynamics of epidemic spread. We have studied the effect of the network structure on models of immune for life diseases and found that in addition to the reduction of the effective transmission rate, through the screening of infectives, spatial correlations may strongly enhance the stochastic fluctuations. As a consequence, time series of unforced Susceptible-Exposed-Infected-Recovered (SEIR) models provide patterns of recurrent epidemics with realistic amplitudes, suggesting that these models together with complex networks of contacts are the key ingredients to describe the prevaccination dynamical patterns of diseases such as measles and pertussis. We have also studied the role of the host contact strucuture in pathogen antigenic variation, through its effect on the final outcome of an invasion by a viral strain of a population where a very similar virus is endemic. Similar viral strains are modelled by the same infection and reinfection parameters, and by a given degree of cross immunity that represents the antigenic distance between the competing strains. We have found, somewhat surprisingly, that clustering on the network decreases the potential to sustain pathogen diversity.

  15. Artificial gravity field, astrophysical analogues, and topological phase transitions in strained topological semimetals

    NASA Astrophysics Data System (ADS)

    Yu, Zhiming; Guan, Shan; Yao, Yugui; Yang, Shengyuan

    Effective gravity and gauge fields are emergent properties intrinsic for low-energy quasiparticles in topological semimetals. Here, taking two Dirac semimetals as examples, we demonstrate that applied lattice strain can generate warped spacetime, with fascinating analogues in astrophysics. Particularly, we study the possibility of simulating black-hole/white-hole event horizons and gravitational lensing effect. Furthermore, we discover strain-induced topological phase transitions, both in the bulk materials and in their thin films. Especially in thin films, the transition between the quantum spin Hall and the trivial insulating phases can be achieved by a small strain, naturally leading to the proposition of a novel piezo-topological transistor device. Our result not only bridges multiple disciplines, revealing topological semimetals as a unique table-top platform for exploring interesting phenomena in astrophysics and general relativity; it also suggests realistic materials and methods to achieve controlled topological phase transitions with great potential for device applications.

  16. Increased Small-World Network Topology Following Deployment-Acquired Traumatic Brain Injury Associated with the Development of Post-Traumatic Stress Disorder.

    PubMed

    Rowland, Jared A; Stapleton-Kotloski, Jennifer R; Dobbins, Dorothy L; Rogers, Emily; Godwin, Dwayne W; Taber, Katherine H

    2018-05-01

    Cross-sectional and longitudinal studies in active duty and veteran cohorts have both demonstrated that deployment-acquired traumatic brain injury (TBI) is an independent risk factor for developing post-traumatic stress disorder (PTSD), beyond confounds such as combat exposure, physical injury, predeployment TBI, and pre-deployment psychiatric symptoms. This study investigated how resting-state brain networks differ between individuals who developed PTSD and those who did not following deployment-acquired TBI. Participants included postdeployment veterans with deployment-acquired TBI history both with and without current PTSD diagnosis. Graph metrics, including small-worldness, clustering coefficient, and modularity, were calculated from individually constructed whole-brain networks based on 5-min eyes-open resting-state magnetoencephalography (MEG) recordings. Analyses were adjusted for age and premorbid IQ. Results demonstrated that participants with current PTSD displayed higher levels of small-worldness, F(1,12) = 5.364, p < 0.039, partial eta squared = 0.309, and Cohen's d = 0.972, and clustering coefficient, F(1, 12) = 12.204, p < 0.004, partial eta squared = 0.504, and Cohen's d = 0.905, than participants without current PTSD. There were no between-group differences in modularity or the number of modules present. These findings are consistent with a hyperconnectivity hypothesis of the effect of TBI history on functional networks rather than a disconnection hypothesis, demonstrating increased levels of clustering coefficient rather than a decrease as might be expected; however, these results do not account for potential changes in brain structure. These results demonstrate the potential pathological sequelae of changes in functional brain networks following deployment-acquired TBI and represent potential neurobiological changes associated with deployment-acquired TBI that may increase the risk of subsequently developing PTSD.

  17. Machine learning topological states

    NASA Astrophysics Data System (ADS)

    Deng, Dong-Ling; Li, Xiaopeng; Das Sarma, S.

    2017-11-01

    Artificial neural networks and machine learning have now reached a new era after several decades of improvement where applications are to explode in many fields of science, industry, and technology. Here, we use artificial neural networks to study an intriguing phenomenon in quantum physics—the topological phases of matter. We find that certain topological states, either symmetry-protected or with intrinsic topological order, can be represented with classical artificial neural networks. This is demonstrated by using three concrete spin systems, the one-dimensional (1D) symmetry-protected topological cluster state and the 2D and 3D toric code states with intrinsic topological orders. For all three cases, we show rigorously that the topological ground states can be represented by short-range neural networks in an exact and efficient fashion—the required number of hidden neurons is as small as the number of physical spins and the number of parameters scales only linearly with the system size. For the 2D toric-code model, we find that the proposed short-range neural networks can describe the excited states with Abelian anyons and their nontrivial mutual statistics as well. In addition, by using reinforcement learning we show that neural networks are capable of finding the topological ground states of nonintegrable Hamiltonians with strong interactions and studying their topological phase transitions. Our results demonstrate explicitly the exceptional power of neural networks in describing topological quantum states, and at the same time provide valuable guidance to machine learning of topological phases in generic lattice models.

  18. Scaling and percolation in the small-world network model

    NASA Astrophysics Data System (ADS)

    Newman, M. E. J.; Watts, D. J.

    1999-12-01

    In this paper we study the small-world network model of Watts and Strogatz, which mimics some aspects of the structure of networks of social interactions. We argue that there is one nontrivial length-scale in the model, analogous to the correlation length in other systems, which is well-defined in the limit of infinite system size and which diverges continuously as the randomness in the network tends to zero, giving a normal critical point in this limit. This length-scale governs the crossover from large- to small-world behavior in the model, as well as the number of vertices in a neighborhood of given radius on the network. We derive the value of the single critical exponent controlling behavior in the critical region and the finite size scaling form for the average vertex-vertex distance on the network, and, using series expansion and Padé approximants, find an approximate analytic form for the scaling function. We calculate the effective dimension of small-world graphs and show that this dimension varies as a function of the length-scale on which it is measured, in a manner reminiscent of multifractals. We also study the problem of site percolation on small-world networks as a simple model of disease propagation, and derive an approximate expression for the percolation probability at which a giant component of connected vertices first forms (in epidemiological terms, the point at which an epidemic occurs). The typical cluster radius satisfies the expected finite size scaling form with a cluster size exponent close to that for a random graph. All our analytic results are confirmed by extensive numerical simulations of the model.

  19. The topology of large-scale structure. V - Two-dimensional topology of sky maps

    NASA Astrophysics Data System (ADS)

    Gott, J. R., III; Mao, Shude; Park, Changbom; Lahav, Ofer

    1992-01-01

    A 2D algorithm is applied to observed sky maps and numerical simulations. It is found that when topology is studied on smoothing scales larger than the correlation length, the topology is approximately in agreement with the random phase formula for the 2D genus-threshold density relation, G2(nu) varies as nu(e) exp-nu-squared/2. Some samples show small 'meatball shifts' similar to those seen in corresponding 3D observational samples and similar to those produced by biasing in cold dark matter simulations. The observational results are thus consistent with the standard model in which the structure in the universe today has grown from small fluctuations caused by random quantum noise in the early universe.

  20. Efficiency of goal-oriented communicating agents in different graph topologies: A study with Internet crawlers

    NASA Astrophysics Data System (ADS)

    Lőrincz, András; Lázár, Katalin A.; Palotai, Zsolt

    2007-05-01

    To what extent does the communication make a goal-oriented community efficient in different topologies? In order to gain insight into this problem, we study the influence of learning method as well as that of the topology of the environment on the communication efficiency of crawlers in quest of novel information in different topics on the Internet. Individual crawlers employ selective learning, function approximation-based reinforcement learning (RL), and their combination. Selective learning, in effect, modifies the starting URL lists of the crawlers, whilst RL alters the URL orderings. Real data have been collected from the web and scale-free worlds, scale-free small world (SFSW), and random world environments (RWEs) have been created by link reorganization. In our previous experiments [ Zs. Palotai, Cs. Farkas, A. Lőrincz, Is selection optimal in scale-free small worlds?, ComPlexUs 3 (2006) 158-168], the crawlers searched for novel, genuine documents and direct communication was not possible. Herein, our finding is reproduced: selective learning performs the best and RL the worst in SFSW, whereas the combined, i.e., selective learning coupled with RL is the best-by a slight margin-in scale-free worlds. This effect is demonstrated to be more pronounced when the crawlers search for different topic-specific documents: the relative performance of the combined learning algorithm improves in all worlds, i.e., in SFSW, in SFW, and in RWE. If the tasks are more complex and the work sharing is enforced by the environment then the combined learning algorithm becomes at least equal, even superior to both the selective and the RL algorithms in most cases, irrespective of the efficiency of communication. Furthermore, communication improves the performance by a large margin and adaptive communication is advantageous in the majority of the cases.

  1. Potts Model in One-Dimension on Directed Small-World Networks

    NASA Astrophysics Data System (ADS)

    Aquino, Édio O.; Lima, F. W. S.; Araújo, Ascânio D.; Costa Filho, Raimundo N.

    2018-06-01

    The critical properties of the Potts model with q=3 and 8 states in one-dimension on directed small-world networks are investigated. This disordered system is simulated by updating it with the Monte Carlo heat bath algorithm. The Potts model on these directed small-world networks presents in fact a second-order phase transition with a new set of critical exponents for q=3 considering a rewiring probability p=0.1. For q=8 the system exhibits only a first-order phase transition independent of p.

  2. Understanding the topological characteristics and flow complexity of urban traffic congestion

    NASA Astrophysics Data System (ADS)

    Wen, Tzai-Hung; Chin, Wei-Chien-Benny; Lai, Pei-Chun

    2017-05-01

    For a growing number of developing cities, the capacities of streets cannot meet the rapidly growing demand of cars, causing traffic congestion. Understanding the spatial-temporal process of traffic flow and detecting traffic congestion are important issues associated with developing sustainable urban policies to resolve congestion. Therefore, the objective of this study is to propose a flow-based ranking algorithm for investigating traffic demands in terms of the attractiveness of street segments and flow complexity of the street network based on turning probability. Our results show that, by analyzing the topological characteristics of streets and volume data for a small fraction of street segments in Taipei City, the most congested segments of the city were identified successfully. The identified congested segments are significantly close to the potential congestion zones, including the officially announced most congested streets, the segments with slow moving speeds at rush hours, and the areas near significant landmarks. The identified congested segments also captured congestion-prone areas concentrated in the business districts and industrial areas of the city. Identifying the topological characteristics and flow complexity of traffic congestion provides network topological insights for sustainable urban planning, and these characteristics can be used to further understand congestion propagation.

  3. The topology of a causal network for the Chinese financial system

    NASA Astrophysics Data System (ADS)

    Gao, Bo; Ren, Ruo-en

    2013-07-01

    The paper builds a causal network for the Chinese financial system based on the Granger causality of company risks, studies its different topologies in crisis and bull period, and applies the centrality to explain individual risk and prevent systemic risk. The results show that this causal network possesses both small-world phenomenon and scale-free property, and has a little different average distance, clustering coefficient, and degree distribution in different periods, and financial institutions with high centrality not only have large individual risk, but also are important for systemic risk immunization.

  4. Globally altered structural brain network topology in grapheme-color synesthesia.

    PubMed

    Hänggi, Jürgen; Wotruba, Diana; Jäncke, Lutz

    2011-04-13

    Synesthesia is a perceptual phenomenon in which stimuli in one particular modality elicit a sensation within the same or another sensory modality (e.g., specific graphemes evoke the perception of particular colors). Grapheme-color synesthesia (GCS) has been proposed to arise from abnormal local cross-activation between grapheme and color areas because of their hyperconnectivity. Recently published studies did not confirm such a hyperconnectivity, although morphometric alterations were found in occipitotemporal, parietal, and frontal regions of synesthetes. We used magnetic resonance imaging surface-based morphometry and graph-theoretical network analyses to investigate the topology of structural brain networks in 24 synesthetes and 24 nonsynesthetes. Connectivity matrices were derived from region-wise cortical thickness correlations of 2366 different cortical parcellations across the whole cortex and from 154 more common brain divisions as well. Compared with nonsynesthetes, synesthetes revealed a globally altered structural network topology as reflected by reduced small-worldness, increased clustering, increased degree, and decreased betweenness centrality. Connectivity of the fusiform gyrus (FuG) and intraparietal sulcus (IPS) was changed as well. Hierarchical modularity analysis revealed increased intramodular and intermodular connectivity of the IPS in GCS. However, connectivity differences in the FuG and IPS showed a low specificity because of global changes. We provide first evidence that GCS is rooted in a reduced small-world network organization that is driven by increased clustering suggesting global hyperconnectivity within the synesthetes' brain. Connectivity alterations were widespread and not restricted to the FuG and IPS. Therefore, synesthetic experience might be only one phenotypic manifestation of the globally altered network architecture in GCS.

  5. A new computational strategy for identifying essential proteins based on network topological properties and biological information.

    PubMed

    Qin, Chao; Sun, Yongqi; Dong, Yadong

    2017-01-01

    Essential proteins are the proteins that are indispensable to the survival and development of an organism. Deleting a single essential protein will cause lethality or infertility. Identifying and analysing essential proteins are key to understanding the molecular mechanisms of living cells. There are two types of methods for predicting essential proteins: experimental methods, which require considerable time and resources, and computational methods, which overcome the shortcomings of experimental methods. However, the prediction accuracy of computational methods for essential proteins requires further improvement. In this paper, we propose a new computational strategy named CoTB for identifying essential proteins based on a combination of topological properties, subcellular localization information and orthologous protein information. First, we introduce several topological properties of the protein-protein interaction (PPI) network. Second, we propose new methods for measuring orthologous information and subcellular localization and a new computational strategy that uses a random forest prediction model to obtain a probability score for the proteins being essential. Finally, we conduct experiments on four different Saccharomyces cerevisiae datasets. The experimental results demonstrate that our strategy for identifying essential proteins outperforms traditional computational methods and the most recently developed method, SON. In particular, our strategy improves the prediction accuracy to 89, 78, 79, and 85 percent on the YDIP, YMIPS, YMBD and YHQ datasets at the top 100 level, respectively.

  6. The topology of large-scale structure. I - Topology and the random phase hypothesis. [galactic formation models

    NASA Technical Reports Server (NTRS)

    Weinberg, David H.; Gott, J. Richard, III; Melott, Adrian L.

    1987-01-01

    Many models for the formation of galaxies and large-scale structure assume a spectrum of random phase (Gaussian), small-amplitude density fluctuations as initial conditions. In such scenarios, the topology of the galaxy distribution on large scales relates directly to the topology of the initial density fluctuations. Here a quantitative measure of topology - the genus of contours in a smoothed density distribution - is described and applied to numerical simulations of galaxy clustering, to a variety of three-dimensional toy models, and to a volume-limited sample of the CfA redshift survey. For random phase distributions the genus of density contours exhibits a universal dependence on threshold density. The clustering simulations show that a smoothing length of 2-3 times the mass correlation length is sufficient to recover the topology of the initial fluctuations from the evolved galaxy distribution. Cold dark matter and white noise models retain a random phase topology at shorter smoothing lengths, but massive neutrino models develop a cellular topology.

  7. Strain-induced topological quantum phase transition in phosphorene oxide

    NASA Astrophysics Data System (ADS)

    Kang, Seoung-Hun; Park, Jejune; Woo, Sungjong; Kwon, Young-Kyun

    Using ab initio density functional theory, we investigate the structural stability and electronic properties of phosphorene oxides (POx) with different oxygen compositions x. A variety of configurations are modeled and optimized geometrically to search for the equilibrium structure for each x value. Our electronic structure calculations on the equilibrium configuration obtained for each x reveal that the band gap tends to increase with the oxygen composition of x < 0.5, and then to decrease with x > 0.5. We further explore the strain effect on the electronic structure of the fully oxidized phosphorene, PO, with x = 1. At a particular strain without spin-orbit coupling (SOC) is observed a band gap closure near the Γ point in the k space. We further find the strain in tandem with SOC induces an interesting band inversion with a reopened very small band gap (5 meV), and thus gives rise to a topological quantum phase transition from a normal insulator to a topological insulator. Such a topological phase transition is confirmed by the wave function analysis and the band topology identified by the Z2 invariant calculation.

  8. Resting state network topology of the ferret brain.

    PubMed

    Zhou, Zhe Charles; Salzwedel, Andrew P; Radtke-Schuller, Susanne; Li, Yuhui; Sellers, Kristin K; Gilmore, John H; Shih, Yen-Yu Ian; Fröhlich, Flavio; Gao, Wei

    2016-12-01

    Resting state functional magnetic resonance imaging (rsfMRI) has emerged as a versatile tool for non-invasive measurement of functional connectivity patterns in the brain. RsfMRI brain dynamics in rodents, non-human primates, and humans share similar properties; however, little is known about the resting state functional connectivity patterns in the ferret, an animal model with high potential for developmental and cognitive translational study. To address this knowledge-gap, we performed rsfMRI on anesthetized ferrets using a 9.4T MRI scanner, and subsequently performed group-level independent component analysis (gICA) to identify functionally connected brain networks. Group-level ICA analysis revealed distributed sensory, motor, and higher-order networks in the ferret brain. Subsequent connectivity analysis showed interconnected higher-order networks that constituted a putative default mode network (DMN), a network that exhibits altered connectivity in neuropsychiatric disorders. Finally, we assessed ferret brain topological efficiency using graph theory analysis and found that the ferret brain exhibits small-world properties. Overall, these results provide additional evidence for pan-species resting-state networks, further supporting ferret-based studies of sensory and cognitive function. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Resting State Network Topology of the Ferret Brain

    PubMed Central

    Zhou, Zhe Charles; Salzwedel, Andrew P.; Radtke-Schuller, Susanne; Li, Yuhui; Sellers, Kristin K.; Gilmore, John H.; Shih, Yen-Yu Ian; Fröhlich, Flavio; Gao, Wei

    2016-01-01

    Resting state functional magnetic resonance imaging (rsfMRI) has emerged as a versatile tool for non-invasive measurement of functional connectivity patterns in the brain. RsfMRI brain dynamics in rodents, non-human primates, and humans share similar properties; however, little is known about the resting state functional connectivity patterns in the ferret, an animal model with high potential for developmental and cognitive translational study. To address this knowledge-gap, we performed rsfMRI on anesthetized ferrets using a 9.4 tesla MRI scanner, and subsequently performed group-level independent component analysis (gICA) to identify functionally connected brain networks. Group-level ICA analysis revealed distributed sensory, motor, and higher-order networks in the ferret brain. Subsequent connectivity analysis showed interconnected higher-order networks that constituted a putative default mode network (DMN), a network that exhibits altered connectivity in neuropsychiatric disorders. Finally, we assessed ferret brain topological efficiency using graph theory analysis and found that the ferret brain exhibits small-world properties. Overall, these results provide additional evidence for pan-species resting-state networks, further supporting ferret-based studies of sensory and cognitive function. PMID:27596024

  10. Scale-free networks which are highly assortative but not small world

    NASA Astrophysics Data System (ADS)

    Small, Michael; Xu, Xiaoke; Zhou, Jin; Zhang, Jie; Sun, Junfeng; Lu, Jun-An

    2008-06-01

    Uncorrelated scale-free networks are necessarily small world (and, in fact, smaller than small world). Nonetheless, for scale-free networks with correlated degree distribution this may not be the case. We describe a mechanism to generate highly assortative scale-free networks which are not small world. We show that it is possible to generate scale-free networks, with arbitrary degree exponent γ>1 , such that the average distance between nodes in the network is large. To achieve this, nodes are not added to the network with preferential attachment. Instead, we greedily optimize the assortativity of the network. The network generation scheme is physically motivated, and we show that the recently observed global network of Avian Influenza outbreaks arises through a mechanism similar to what we present here. Simulations show that this network exhibits very similar physical characteristics (very high assortativity, clustering, and path length).

  11. Network marketing on a small-world network

    NASA Astrophysics Data System (ADS)

    Kim, Beom Jun; Jun, Tackseung; Kim, Jeong-Yoo; Choi, M. Y.

    2006-02-01

    We investigate a dynamic model of network marketing in a small-world network structure artificially constructed similarly to the Watts-Strogatz network model. Different from the traditional marketing, consumers can also play the role of the manufacturer's selling agents in network marketing, which is stimulated by the referral fee the manufacturer offers. As the wiring probability α is increased from zero to unity, the network changes from the one-dimensional regular directed network to the star network where all but one player are connected to one consumer. The price p of the product and the referral fee r are used as free parameters to maximize the profit of the manufacturer. It is observed that at α=0 the maximized profit is constant independent of the network size N while at α≠0, it increases linearly with N. This is in parallel to the small-world transition. It is also revealed that while the optimal value of p stays at an almost constant level in a broad range of α, that of r is sensitive to a change in the network structure. The consumer surplus is also studied and discussed.

  12. The world problem: on the computability of the topology of 4-manifolds

    NASA Technical Reports Server (NTRS)

    vanMeter, J. R.

    2005-01-01

    Topological classification of the 4-manifolds bridges computation theory and physics. A proof of the undecidability of the homeomorphy problem for 4-manifolds is outlined here in a clarifying way. It is shown that an arbitrary Turing machine with an arbitrary input can be encoded into the topology of a 4-manifold, such that the 4-manifold is homeomorphic to a certain other 4-manifold if and only if the corresponding Turing machine halts on the associated input. Physical implications are briefly discussed.

  13. Wealth redistribution in our small world

    NASA Astrophysics Data System (ADS)

    Iglesias, J. R.; Gonçalves, S.; Pianegonda, S.; Vega, J. L.; Abramson, G.

    2003-09-01

    We present a simplified model for the exploitation of resources by interacting agents, in an economy with small-world properties. It is shown that Gaussian distributions of wealth, with some cutoff at a poverty line are present for all values of the parameters, while the frequency of maxima and minima strongly depends on the connectivity and the disorder of the lattice. Finally, we compare a system where the commercial links are frozen with an economy where agents can choose their commercial partners at each time step.

  14. Synthesizing topological structures containing RNA

    NASA Astrophysics Data System (ADS)

    Liu, Di; Shao, Yaming; Chen, Gang; Tse-Dinh, Yuk-Ching; Piccirilli, Joseph A.; Weizmann, Yossi

    2017-03-01

    Though knotting and entanglement have been observed in DNA and proteins, their existence in RNA remains an enigma. Synthetic RNA topological structures are significant for understanding the physical and biological properties pertaining to RNA topology, and these properties in turn could facilitate identifying naturally occurring topologically nontrivial RNA molecules. Here we show that topological structures containing single-stranded RNA (ssRNA) free of strong base pairing interactions can be created either by configuring RNA-DNA hybrid four-way junctions or by template-directed synthesis with a single-stranded DNA (ssDNA) topological structure. By using a constructed ssRNA knot as a highly sensitive topological probe, we find that Escherichia coli DNA topoisomerase I has low RNA topoisomerase activity and that the R173A point mutation abolishes the unknotting activity for ssRNA, but not for ssDNA. Furthermore, we discover the topological inhibition of reverse transcription (RT) and obtain different RT-PCR patterns for an ssRNA knot and circle of the same sequence.

  15. A topology visualization early warning distribution algorithm for large-scale network security incidents.

    PubMed

    He, Hui; Fan, Guotao; Ye, Jianwei; Zhang, Weizhe

    2013-01-01

    It is of great significance to research the early warning system for large-scale network security incidents. It can improve the network system's emergency response capabilities, alleviate the cyber attacks' damage, and strengthen the system's counterattack ability. A comprehensive early warning system is presented in this paper, which combines active measurement and anomaly detection. The key visualization algorithm and technology of the system are mainly discussed. The large-scale network system's plane visualization is realized based on the divide and conquer thought. First, the topology of the large-scale network is divided into some small-scale networks by the MLkP/CR algorithm. Second, the sub graph plane visualization algorithm is applied to each small-scale network. Finally, the small-scale networks' topologies are combined into a topology based on the automatic distribution algorithm of force analysis. As the algorithm transforms the large-scale network topology plane visualization problem into a series of small-scale network topology plane visualization and distribution problems, it has higher parallelism and is able to handle the display of ultra-large-scale network topology.

  16. Classical topological paramagnetism

    NASA Astrophysics Data System (ADS)

    Bondesan, R.; Ringel, Z.

    2017-05-01

    Topological phases of matter are one of the hallmarks of quantum condensed matter physics. One of their striking features is a bulk-boundary correspondence wherein the topological nature of the bulk manifests itself on boundaries via exotic massless phases. In classical wave phenomena, analogous effects may arise; however, these cannot be viewed as equilibrium phases of matter. Here, we identify a set of rules under which robust equilibrium classical topological phenomena exist. We write simple and analytically tractable classical lattice models of spins and rotors in two and three dimensions which, at suitable parameter ranges, are paramagnetic in the bulk but nonetheless exhibit some unusual long-range or critical order on their boundaries. We point out the role of simplicial cohomology as a means of classifying, writing, and analyzing such models. This opens an experimental route for studying strongly interacting topological phases of spins.

  17. Topological Galleries: A High Level User Interface for Topology Controlled Volume Rendering

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MacCarthy, Brian; Carr, Hamish; Weber, Gunther H.

    2011-06-30

    Existing topological interfaces to volume rendering are limited by their reliance on sophisticated knowledge of topology by the user. We extend previous work by describing topological galleries, an interface for novice users that is based on the design galleries approach. We report three contributions: an interface based on hierarchical thumbnail galleries to display the containment relationships between topologically identifiable features, the use of the pruning hierarchy instead of branch decomposition for contour tree simplification, and drag-and-drop transfer function assignment for individual components. Initial results suggest that this approach suffers from limitations due to rapid drop-off of feature size in themore » pruning hierarchy. We explore these limitations by providing statistics of feature size as function of depth in the pruning hierarchy of the contour tree.« less

  18. Homeostatic structural plasticity can account for topology changes following deafferentation and focal stroke.

    PubMed

    Butz, Markus; Steenbuck, Ines D; van Ooyen, Arjen

    2014-01-01

    After brain lesions caused by tumors or stroke, or after lasting loss of input (deafferentation), inter- and intra-regional brain networks respond with complex changes in topology. Not only areas directly affected by the lesion but also regions remote from the lesion may alter their connectivity-a phenomenon known as diaschisis. Changes in network topology after brain lesions can lead to cognitive decline and increasing functional disability. However, the principles governing changes in network topology are poorly understood. Here, we investigated whether homeostatic structural plasticity can account for changes in network topology after deafferentation and brain lesions. Homeostatic structural plasticity postulates that neurons aim to maintain a desired level of electrical activity by deleting synapses when neuronal activity is too high and by providing new synaptic contacts when activity is too low. Using our Model of Structural Plasticity, we explored how local changes in connectivity induced by a focal loss of input affected global network topology. In accordance with experimental and clinical data, we found that after partial deafferentation, the network as a whole became more random, although it maintained its small-world topology, while deafferentated neurons increased their betweenness centrality as they rewired and returned to the homeostatic range of activity. Furthermore, deafferentated neurons increased their global but decreased their local efficiency and got longer tailed degree distributions, indicating the emergence of hub neurons. Together, our results suggest that homeostatic structural plasticity may be an important driving force for lesion-induced network reorganization and that the increase in betweenness centrality of deafferentated areas may hold as a biomarker for brain repair.

  19. Learning and innovative elements of strategy adoption rules expand cooperative network topologies.

    PubMed

    Wang, Shijun; Szalay, Máté S; Zhang, Changshui; Csermely, Peter

    2008-04-09

    Cooperation plays a key role in the evolution of complex systems. However, the level of cooperation extensively varies with the topology of agent networks in the widely used models of repeated games. Here we show that cooperation remains rather stable by applying the reinforcement learning strategy adoption rule, Q-learning on a variety of random, regular, small-word, scale-free and modular network models in repeated, multi-agent Prisoner's Dilemma and Hawk-Dove games. Furthermore, we found that using the above model systems other long-term learning strategy adoption rules also promote cooperation, while introducing a low level of noise (as a model of innovation) to the strategy adoption rules makes the level of cooperation less dependent on the actual network topology. Our results demonstrate that long-term learning and random elements in the strategy adoption rules, when acting together, extend the range of network topologies enabling the development of cooperation at a wider range of costs and temptations. These results suggest that a balanced duo of learning and innovation may help to preserve cooperation during the re-organization of real-world networks, and may play a prominent role in the evolution of self-organizing, complex systems.

  20. The topology of galaxy clustering.

    NASA Astrophysics Data System (ADS)

    Coles, P.; Plionis, M.

    The authors discuss an objective method for quantifying the topology of the galaxy distribution using only projected galaxy counts. The method is a useful complement to fully three-dimensional studies of topology based on the genus by virtue of the enormous projected data sets available. Applying the method to the Lick counts they find no evidence for large-scale non-gaussian behaviour, whereas the small-scale distribution is strongly non-gaussian, with a shift in the meatball direction.

  1. A structural topological optimization method for multi-displacement constraints and any initial topology configuration

    NASA Astrophysics Data System (ADS)

    Rong, J. H.; Yi, J. H.

    2010-10-01

    In density-based topological design, one expects that the final result consists of elements either black (solid material) or white (void), without any grey areas. Moreover, one also expects that the optimal topology can be obtained by starting from any initial topology configuration. An improved structural topological optimization method for multi- displacement constraints is proposed in this paper. In the proposed method, the whole optimization process is divided into two optimization adjustment phases and a phase transferring step. Firstly, an optimization model is built to deal with the varied displacement limits, design space adjustments, and reasonable relations between the element stiffness matrix and mass and its element topology variable. Secondly, a procedure is proposed to solve the optimization problem formulated in the first optimization adjustment phase, by starting with a small design space and advancing to a larger deign space. The design space adjustments are automatic when the design domain needs expansions, in which the convergence of the proposed method will not be affected. The final topology obtained by the proposed procedure in the first optimization phase, can approach to the vicinity of the optimum topology. Then, a heuristic algorithm is given to improve the efficiency and make the designed structural topology black/white in both the phase transferring step and the second optimization adjustment phase. And the optimum topology can finally be obtained by the second phase optimization adjustments. Two examples are presented to show that the topologies obtained by the proposed method are of very good 0/1 design distribution property, and the computational efficiency is enhanced by reducing the element number of the design structural finite model during two optimization adjustment phases. And the examples also show that this method is robust and practicable.

  2. A method of examining the structure and topological properties of public-transport networks

    NASA Astrophysics Data System (ADS)

    Dimitrov, Stavri Dimitri; Ceder, Avishai (Avi)

    2016-06-01

    This work presents a new method of examining the structure of public-transport networks (PTNs) and analyzes their topological properties through a combination of computer programming, statistical data and large-network analyses. In order to automate the extraction, processing and exporting of data, a software program was developed allowing to extract the needed data from General Transit Feed Specification, thus overcoming difficulties occurring in accessing and collecting data. The proposed method was applied to a real-life PTN in Auckland, New Zealand, with the purpose of examining whether it showed characteristics of scale-free networks and exhibited features of ;small-world; networks. As a result, new regression equations were derived analytically describing observed, strong, non-linear relationships among the probabilities of randomly chosen stops in the PTN to be serviced by a given number of routes. The established dependence is best fitted by an exponential rather than a power-law function, showing that the PTN examined is neither random nor scale-free, but a mixture of the two. This finding explains the presence of hubs that are not typical of exponential networks and simultaneously not highly connected to the other nodes as is the case with scale-free networks. On the other hand, the observed values of the topological properties of the network show that although it is highly clustered, owing to its representation as a directed graph, it differs slightly from ;small-world; networks, which are characterized by strong clustering and a short average path length.

  3. Whole-lake invasive crayfish removal and qualitative modeling reveal habitat-specific food web topology

    DOE PAGES

    Hansen, Gretchen J. A.; Tunney, Tyler D.; Winslow, Luke A.; ...

    2017-02-10

    Patterning of the presence/absence of food web linkages (hereafter topology) is a fundamental characteristic of ecosystems that can influence species responses to perturbations. However, the insight from food web topology into dynamic effects of perturbations on species is potentially hindered because most described topologies represent data integrated across spatial and temporal scales. We conducted a 10-year, whole-lake experiment in which we removed invasive rusty crayfish ( Orconectes rusticus) from a 64-ha north-temperate lake and monitored responses of multiple trophic levels. We compared species responses observed in two sub-habitats to the responses predicted from all topologies of an integrated, literature-informed basemore » food web model of 32 potential links. Out of 4.3 billion possible topologies, only 308,833 (0.0072%) predicted responses that qualitatively matched observed species responses in cobble habitat, and only 12,673 (0.0003%) matched observed responses in sand habitat. Furthermore, when constrained to predictions that both matched observed responses and were highly reliable (i.e., predictions were robust to link strength values), only 5040 (0.0001%) and 140 (0.000003%) topologies were identified for cobble and sand habitats, respectively. A small number of linkages were nearly always present in these valid, reliable networks in sand, while a greater variety of possible network configurations were possible in cobble. Direct links involving invasive rusty crayfish were more important in cobble, while indirect effects involving Lepomis spp. were more important in sand. Importantly, the importance of individual species linkages differed dramatically among cobble and sand sub-habitats within a single lake, even though species composition was identical. Furthermore the true topology of food webs is difficult to determine, constraining topologies to include spatial resolution that matches observed experimental outcomes may reduce possibilities

  4. Whole-lake invasive crayfish removal and qualitative modeling reveal habitat-specific food web topology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hansen, Gretchen J. A.; Tunney, Tyler D.; Winslow, Luke A.

    Patterning of the presence/absence of food web linkages (hereafter topology) is a fundamental characteristic of ecosystems that can influence species responses to perturbations. However, the insight from food web topology into dynamic effects of perturbations on species is potentially hindered because most described topologies represent data integrated across spatial and temporal scales. We conducted a 10-year, whole-lake experiment in which we removed invasive rusty crayfish ( Orconectes rusticus) from a 64-ha north-temperate lake and monitored responses of multiple trophic levels. We compared species responses observed in two sub-habitats to the responses predicted from all topologies of an integrated, literature-informed basemore » food web model of 32 potential links. Out of 4.3 billion possible topologies, only 308,833 (0.0072%) predicted responses that qualitatively matched observed species responses in cobble habitat, and only 12,673 (0.0003%) matched observed responses in sand habitat. Furthermore, when constrained to predictions that both matched observed responses and were highly reliable (i.e., predictions were robust to link strength values), only 5040 (0.0001%) and 140 (0.000003%) topologies were identified for cobble and sand habitats, respectively. A small number of linkages were nearly always present in these valid, reliable networks in sand, while a greater variety of possible network configurations were possible in cobble. Direct links involving invasive rusty crayfish were more important in cobble, while indirect effects involving Lepomis spp. were more important in sand. Importantly, the importance of individual species linkages differed dramatically among cobble and sand sub-habitats within a single lake, even though species composition was identical. Furthermore the true topology of food webs is difficult to determine, constraining topologies to include spatial resolution that matches observed experimental outcomes may reduce possibilities

  5. Novel subgroups of attention-deficit/hyperactivity disorder identified by topological data analysis and their functional network modular organizations

    PubMed Central

    Kyeong, Sunghyon; Kim, Jae-Jin; Kim, Eunjoo

    2017-01-01

    Attention-deficit/hyperactivity disorder (ADHD) is a clinically heterogeneous condition and identification of clinically meaningful subgroups would open up a new window for personalized medicine. Thus, we aimed to identify new clinical phenotypes in children and adolescents with ADHD and to investigate whether neuroimaging findings validate the identified phenotypes. Neuroimaging and clinical data from 67 children with ADHD and 62 typically developing controls (TDCs) from the ADHD-200 database were selected. Clinical measures of ADHD symptoms and intelligence quotient (IQ) were used as input features into a topological data analysis (TDA) to identify ADHD subgroups within our sample. As external validators, graph theoretical measures obtained from the functional connectome were compared to address the biological meaningfulness of the identified subtypes. The TDA identified two unique subgroups of ADHD, labelled as mild symptom ADHD (mADHD) and severe symptom ADHD (sADHD). The output topology shape was repeatedly observed in the independent validation dataset. The graph theoretical analysis showed a decrease in the degree centrality and PageRank in the bilateral posterior cingulate cortex in the sADHD group compared with the TDC group. The mADHD group showed similar patterns of intra- and inter-module connectivity to the sADHD group. Relative to the TDC group, the inter-module connectivity between the default mode network and executive control network were significantly increased in the sADHD group but not in the mADHD group. Taken together, our results show that the data-driven TDA is potentially useful in identifying objective and biologically relevant disease phenotypes in children and adolescents with ADHD. PMID:28829775

  6. Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains.

    PubMed

    Ron, Gil; Globerson, Yuval; Moran, Dror; Kaplan, Tommy

    2017-12-21

    Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here, we present PSYCHIC, a computational approach for analyzing Hi-C data and identifying promoter-enhancer interactions. We use a unified probabilistic model to segment the genome into domains, which we then merge hierarchically and fit using a local background model, allowing us to identify over-represented DNA-DNA interactions across the genome. By analyzing the published Hi-C data sets in human and mouse, we identify hundreds of thousands of putative enhancers and their target genes, and compile an extensive genome-wide catalog of gene regulation in human and mouse. As we show, our predictions are highly enriched for ChIP-seq and DNA accessibility data, evolutionary conservation, eQTLs and other DNA-DNA interaction data.

  7. TopologyNet: Topology based deep convolutional and multi-task neural networks for biomolecular property predictions

    PubMed Central

    2017-01-01

    Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered by the geometric and biological complexity. To address this problem we introduce the element-specific persistent homology (ESPH) method. ESPH represents 3D complex geometry by one-dimensional (1D) topological invariants and retains important biological information via a multichannel image-like representation. This representation reveals hidden structure-function relationships in biomolecules. We further integrate ESPH and deep convolutional neural networks to construct a multichannel topological neural network (TopologyNet) for the predictions of protein-ligand binding affinities and protein stability changes upon mutation. To overcome the deep learning limitations from small and noisy training sets, we propose a multi-task multichannel topological convolutional neural network (MM-TCNN). We demonstrate that TopologyNet outperforms the latest methods in the prediction of protein-ligand binding affinities, mutation induced globular protein folding free energy changes, and mutation induced membrane protein folding free energy changes. Availability: weilab.math.msu.edu/TDL/ PMID:28749969

  8. Topological phase transitions from Harper to Fibonacci crystals

    NASA Astrophysics Data System (ADS)

    Amit, Guy; Dana, Itzhack

    2018-02-01

    Topological properties of Harper and generalized Fibonacci chains are studied in crystalline cases, i.e., for rational values of the modulation frequency. The Harper and Fibonacci crystals at fixed frequency are connected by an interpolating one-parameter Hamiltonian. As the parameter is varied, one observes topological phase transitions, i.e., changes in the Chern integers of two bands due to the degeneracy of these bands at some parameter value. For small frequency, corresponding to a semiclassical regime, the degeneracies are shown to occur when the average energy of the two bands is approximately equal to the energy of the classical separatrix. Spectral and topological features of the Fibonacci crystal for small frequency leave a clear imprint on the corresponding Hofstadter butterfly for arbitrary frequency.

  9. Exotic Lifshitz transitions in topological materials

    NASA Astrophysics Data System (ADS)

    Volovik, G. E.

    2018-01-01

    Topological Lifshitz transitions involve many types of topological structures in momentum and frequency-momentum spaces, such as Fermi surfaces, Dirac lines, Dirac and Weyl points, etc., each of which has its own stability-supporting topological invariant ( N_1, N_2, N_3, {\\tilde N}_3, etc.). The topology of the shape of Fermi surfaces and Dirac lines and the interconnection of objects of different dimensionalities produce a variety of Lifshitz transition classes. Lifshitz transitions have important implications for many areas of physics. To give examples, transition-related singularities can increase the superconducting transition temperature; Lifshitz transitions are the possible origin of the small masses of elementary particles in our Universe, and a black hole horizon serves as the surface of the Lifshitz transition between vacua with type-I and type-II Weyl points.

  10. Complete theory of symmetry-based indicators of band topology.

    PubMed

    Po, Hoi Chun; Vishwanath, Ashvin; Watanabe, Haruki

    2017-06-30

    The interplay between symmetry and topology leads to a rich variety of electronic topological phases, protecting states such as the topological insulators and Dirac semimetals. Previous results, like the Fu-Kane parity criterion for inversion-symmetric topological insulators, demonstrate that symmetry labels can sometimes unambiguously indicate underlying band topology. Here we develop a systematic approach to expose all such symmetry-based indicators of band topology in all the 230 space groups. This is achieved by first developing an efficient way to represent band structures in terms of elementary basis states, and then isolating the topological ones by removing the subset of atomic insulators, defined by the existence of localized symmetric Wannier functions. Aside from encompassing all earlier results on such indicators, including in particular the notion of filling-enforced quantum band insulators, our theory identifies symmetry settings with previously hidden forms of band topology, and can be applied to the search for topological materials.Understanding the role of topology in determining electronic structure can lead to the discovery, or appreciation, of materials with exotic properties such as protected surface states. Here, the authors present a framework for identifying topologically distinct band-structures for all 3D space groups.

  11. Semilinear (topological) spaces and applications

    NASA Technical Reports Server (NTRS)

    Prakash, P.; Sertel, M. R.

    1971-01-01

    Semivector spaces are defined and some of their algebraic aspects are developed including some structure theory. These spaces are then topologized to obtain semilinear topological spaces for which a hierarchy of local convexity axioms is identified. A number of fixed point and minmax theorems for spaces with various local convexity properties are established. The spaces of concern arise naturally as various hyperspaces of linear and semilinear (topological) spaces. It is indicated briefly how all this can be applied in socio-economic analysis and optimization.

  12. Evolution versus "intelligent design": comparing the topology of protein-protein interaction networks to the Internet.

    PubMed

    Yang, Q; Siganos, G; Faloutsos, M; Lonardi, S

    2006-01-01

    Recent research efforts have made available genome-wide, high-throughput protein-protein interaction (PPI) maps for several model organisms. This has enabled the systematic analysis of PPI networks, which has become one of the primary challenges for the system biology community. In this study, we attempt to understand better the topological structure of PPI networks by comparing them against man-made communication networks, and more specifically, the Internet. Our comparative study is based on a comprehensive set of graph metrics. Our results exhibit an interesting dichotomy. On the one hand, both networks share several macroscopic properties such as scale-free and small-world properties. On the other hand, the two networks exhibit significant topological differences, such as the cliqueishness of the highest degree nodes. We attribute these differences to the distinct design principles and constraints that both networks are assumed to satisfy. We speculate that the evolutionary constraints that favor the survivability and diversification are behind the building process of PPI networks, whereas the leading force in shaping the Internet topology is a decentralized optimization process geared towards efficient node communication.

  13. On the structural properties of small-world networks with range-limited shortcut links

    NASA Astrophysics Data System (ADS)

    Jia, Tao; Kulkarni, Rahul V.

    2013-12-01

    We explore a new variant of Small-World Networks (SWNs), in which an additional parameter (r) sets the length scale over which shortcuts are uniformly distributed. When r=0 we have an ordered network, whereas r=1 corresponds to the original Watts-Strogatz SWN model. These limited range SWNs have a similar degree distribution and scaling properties as the original SWN model. We observe the small-world phenomenon for r≪1, indicating that global shortcuts are not necessary for the small-world effect. For limited range SWNs, the average path length changes nonmonotonically with system size, whereas for the original SWN model it increases monotonically. We propose an expression for the average path length for limited range SWNs based on numerical simulations and analytical approximations.

  14. a Model Study of Small-Scale World Map Generalization

    NASA Astrophysics Data System (ADS)

    Cheng, Y.; Yin, Y.; Li, C. M.; Wu, W.; Guo, P. P.; Ma, X. L.; Hu, F. M.

    2018-04-01

    With the globalization and rapid development every filed is taking an increasing interest in physical geography and human economics. There is a surging demand for small scale world map in large formats all over the world. Further study of automated mapping technology, especially the realization of small scale production on a large scale global map, is the key of the cartographic field need to solve. In light of this, this paper adopts the improved model (with the map and data separated) in the field of the mapmaking generalization, which can separate geographic data from mapping data from maps, mainly including cross-platform symbols and automatic map-making knowledge engine. With respect to the cross-platform symbol library, the symbol and the physical symbol in the geographic information are configured at all scale levels. With respect to automatic map-making knowledge engine consists 97 types, 1086 subtypes, 21845 basic algorithm and over 2500 relevant functional modules.In order to evaluate the accuracy and visual effect of our model towards topographic maps and thematic maps, we take the world map generalization in small scale as an example. After mapping generalization process, combining and simplifying the scattered islands make the map more explicit at 1 : 2.1 billion scale, and the map features more complete and accurate. Not only it enhance the map generalization of various scales significantly, but achieve the integration among map-makings of various scales, suggesting that this model provide a reference in cartographic generalization for various scales.

  15. A small-world network model of facial emotion recognition.

    PubMed

    Takehara, Takuma; Ochiai, Fumio; Suzuki, Naoto

    2016-01-01

    Various models have been proposed to increase understanding of the cognitive basis of facial emotions. Despite those efforts, interactions between facial emotions have received minimal attention. If collective behaviours relating to each facial emotion in the comprehensive cognitive system could be assumed, specific facial emotion relationship patterns might emerge. In this study, we demonstrate that the frameworks of complex networks can effectively capture those patterns. We generate 81 facial emotion images (6 prototypes and 75 morphs) and then ask participants to rate degrees of similarity in 3240 facial emotion pairs in a paired comparison task. A facial emotion network constructed on the basis of similarity clearly forms a small-world network, which features an extremely short average network distance and close connectivity. Further, even if two facial emotions have opposing valences, they are connected within only two steps. In addition, we show that intermediary morphs are crucial for maintaining full network integration, whereas prototypes are not at all important. These results suggest the existence of collective behaviours in the cognitive systems of facial emotions and also describe why people can efficiently recognize facial emotions in terms of information transmission and propagation. For comparison, we construct three simulated networks--one based on the categorical model, one based on the dimensional model, and one random network. The results reveal that small-world connectivity in facial emotion networks is apparently different from those networks, suggesting that a small-world network is the most suitable model for capturing the cognitive basis of facial emotions.

  16. Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea

    PubMed Central

    Chen, Liting; Fan, Xiaole; Li, Haijun; Ye, Chenglong; Yu, Honghui; Gong, Honghan; Zeng, Xianjun; Peng, Dechang; Yan, Liping

    2018-01-01

    Impaired spontaneous regional activity and altered topology of the brain network have been observed in obstructive sleep apnea (OSA). However, the mechanisms of disrupted functional connectivity (FC) and topological reorganization of the default mode network (DMN) in patients with OSA remain largely unknown. We explored whether the FC is altered within the DMN and examined topological changes occur in the DMN in patients with OSA using a graph theory analysis of resting-state functional magnetic resonance imaging data and evaluated the relationship between neuroimaging measures and clinical variables. Resting-state data were obtained from 46 male patients with untreated severe OSA and 46 male good sleepers (GSs). We specifically selected 20 DMN subregions to construct the DMN architecture. The disrupted FC and topological properties of the DMN in patients with OSA were characterized using graph theory. The OSA group showed significantly decreased FC of the anterior–posterior DMN and within the posterior DMN, and also showed increased FC within the DMN. The DMN exhibited small-world topology in both OSA and GS groups. Compared to GSs, patients with OSA showed a decreased clustering coefficient (Cp) and local efficiency, and decreased nodal centralities in the left posterior cingulate cortex and dorsal medial prefrontal cortex, and increased nodal centralities in the ventral medial prefrontal cortex and the right parahippocampal cortex. Finally, the abnormal DMN FC was significantly related to Cp, path length, global efficiency, and Montreal cognitive assessment score. OSA showed disrupted FC within the DMN, which may have contributed to the observed topological reorganization. These findings may provide further evidence of cognitive deficits in patients with OSA.

  17. Topology optimization under stochastic stiffness

    NASA Astrophysics Data System (ADS)

    Asadpoure, Alireza

    Topology optimization is a systematic computational tool for optimizing the layout of materials within a domain for engineering design problems. It allows variation of structural boundaries and connectivities. This freedom in the design space often enables discovery of new, high performance designs. However, solutions obtained by performing the optimization in a deterministic setting may be impractical or suboptimal when considering real-world engineering conditions with inherent variabilities including (for example) variabilities in fabrication processes and operating conditions. The aim of this work is to provide a computational methodology for topology optimization in the presence of uncertainties associated with structural stiffness, such as uncertain material properties and/or structural geometry. Existing methods for topology optimization under deterministic conditions are first reviewed. Modifications are then proposed to improve the numerical performance of the so-called Heaviside Projection Method (HPM) in continuum domains. Next, two approaches, perturbation and Polynomial Chaos Expansion (PCE), are proposed to account for uncertainties in the optimization procedure. These approaches are intrusive, allowing tight and efficient coupling of the uncertainty quantification with the optimization sensitivity analysis. The work herein develops a robust topology optimization framework aimed at reducing the sensitivity of optimized solutions to uncertainties. The perturbation-based approach combines deterministic topology optimization with a perturbation method for the quantification of uncertainties. The use of perturbation transforms the problem of topology optimization under uncertainty to an augmented deterministic topology optimization problem. The PCE approach combines the spectral stochastic approach for the representation and propagation of uncertainties with an existing deterministic topology optimization technique. The resulting compact representations

  18. Evaluating the Small-World-Ness of a Sampled Network: Functional Connectivity of Entorhinal-Hippocampal Circuitry

    NASA Astrophysics Data System (ADS)

    She, Qi; Chen, Guanrong; Chan, Rosa H. M.

    2016-02-01

    The amount of publicly accessible experimental data has gradually increased in recent years, which makes it possible to reconsider many longstanding questions in neuroscience. In this paper, an efficient framework is presented for reconstructing functional connectivity using experimental spike-train data. A modified generalized linear model (GLM) with L1-norm penalty was used to investigate 10 datasets. These datasets contain spike-train data collected from the entorhinal-hippocampal region in the brains of rats performing different tasks. The analysis shows that entorhinal-hippocampal network of well-trained rats demonstrated significant small-world features. It is found that the connectivity structure generated by distance-dependent models is responsible for the observed small-world features of the reconstructed networks. The models are utilized to simulate a subset of units recorded from a large biological neural network using multiple electrodes. Two metrics for quantifying the small-world-ness both suggest that the reconstructed network from the sampled nodes estimates a more prominent small-world-ness feature than that of the original unknown network when the number of recorded neurons is small. Finally, this study shows that it is feasible to adjust the estimated small-world-ness results based on the number of neurons recorded to provide a more accurate reference of the network property.

  19. Six Degrees of Information Seeking: Stanley Milgram and the Small World of the Library

    ERIC Educational Resources Information Center

    James, Kathryn

    2006-01-01

    Stanley Milgram's 1967 "small world" social connectivity study is used to analyze information connectivity, or patron information-seeking behavior. The "small world" study, upon examination, offers a clear example of the failure of social connectivity. This failure is used to highlight the importance of the subjectivities of patron experience of…

  20. Topology of polymer chains under nanoscale confinement.

    PubMed

    Satarifard, Vahid; Heidari, Maziar; Mashaghi, Samaneh; Tans, Sander J; Ejtehadi, Mohammad Reza; Mashaghi, Alireza

    2017-08-24

    Spatial confinement limits the conformational space accessible to biomolecules but the implications for bimolecular topology are not yet known. Folded linear biopolymers can be seen as molecular circuits formed by intramolecular contacts. The pairwise arrangement of intra-chain contacts can be categorized as parallel, series or cross, and has been identified as a topological property. Using molecular dynamics simulations, we determine the contact order distributions and topological circuits of short semi-flexible linear and ring polymer chains with a persistence length of l p under a spherical confinement of radius R c . At low values of l p /R c , the entropy of the linear chain leads to the formation of independent contacts along the chain and accordingly, increases the fraction of series topology with respect to other topologies. However, at high l p /R c , the fraction of cross and parallel topologies are enhanced in the chain topological circuits with cross becoming predominant. At an intermediate confining regime, we identify a critical value of l p /R c , at which all topological states have equal probability. Confinement thus equalizes the probability of more complex cross and parallel topologies to the level of the more simple, non-cooperative series topology. Moreover, our topology analysis reveals distinct behaviours for ring- and linear polymers under weak confinement; however, we find no difference between ring- and linear polymers under strong confinement. Under weak confinement, ring polymers adopt parallel and series topologies with equal likelihood, while linear polymers show a higher tendency for series arrangement. The radial distribution analysis of the topology reveals a non-uniform effect of confinement on the topology of polymer chains, thereby imposing more pronounced effects on the core region than on the confinement surface. Additionally, our results reveal that over a wide range of confining radii, loops arranged in parallel and cross

  1. Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia.

    PubMed

    Nan, Jiaofen; Zhang, Li; Zhu, Fubao; Tian, Xiaorui; Zheng, Qian; Deneen, Karen M von; Liu, Jixin; Zhang, Ming

    2016-01-31

    Previous studies reported that integrated information in the brain ultimately determines the subjective experience of patients with chronic pain, but how the information is integrated in the brain connectome of functional dyspepsia (FD) patients remains largely unclear. The study aimed to quantify the topological changes of the brain network in FD patients. Small-world properties, network efficiency and nodal centrality were utilized to measure the changes in topological architecture in 25 FD patients and 25 healthy controls based on functional magnetic resonance imaging. Pearson's correlation assessed the relationship of each topological property with clinical symptoms. FD patients showed an increase of clustering coefficients and local efficiency relative to controls from the perspective of a whole network as well as elevated nodal centrality in the right orbital part of the inferior frontal gyrus, left anterior cingulate gyrus and left hippocampus, and decreased nodal centrality in the right posterior cingulate gyrus, left cuneus, right putamen, left middle occipital gyrus and right inferior occipital gyrus. Moreover, the centrality in the anterior cingulate gyrus was significantly associated with symptom severity and duration in FD patients. Nevertheless, the inclusion of anxiety and depression scores as covariates erased the group differences in nodal centralities in the orbital part of the inferior frontal gyrus and hippocampus. The results suggest topological disruption of the functional brain networks in FD patients, presumably in response to disturbances of sensory information integrated with emotion, memory, pain modulation, and selective attention in patients.

  2. The Albedo of Kepler's Small Worlds

    NASA Astrophysics Data System (ADS)

    Jansen, Tiffany; Kipping, David

    2018-01-01

    The study of exoplanet phase curves has been established as a powerful tool for measuring the atmospheric properties of other worlds. To first order, phase curves have the same amplitude as occultations, yet far greater temporal baselines enabling substantial improvements in sensitivity. Even so, only a relatively small fraction of Kepler planets have detectable phase curves, leading to a population dominated by hot-Jupiters. One way to boost sensitivity further is to stack different planets of similar types together, giving rise to an average phase curve for a specific ensemble. In this work, we measure the average albedo, thermal redistribution efficiency, and greenhouse boosting factor from the average phase curves of 115 Neptunian and 50 Terran (solid) worlds. We construct ensemble phase curve models for both samples accounting for the reflection and thermal components and regress our models assuming a global albedo, redistribution factor and greenhouse factor in a Bayesian framework. We find modest evidence for a detected phase curve in the Neptunian sample, although the albedo and thermal properties are somewhat degenerate meaning we can only place an upper limit on the albedo of Ag < 0.23 and greenhouse factor of f < 1.40 to 95% confidence. As predicted theoretically, this confirms hot-Neptunes are darker than Neptune and Uranus. Additionally, we place a constraint on the albedo of solid, Terran worlds of Ag < 0.42 and f < 1.60 to 95% confidence, compatible with a dark Lunar-like surface.

  3. Computational Search for Strong Topological Insulators: An Exercise in Data Mining and Electronic Structure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klintenberg, M.; Haraldsen, Jason T.; Balatsky, Alexander V.

    In this paper, we report a data-mining investigation for the search of topological insulators by examining individual electronic structures for over 60,000 materials. Using a data-mining algorithm, we survey changes in band inversion with and without spin-orbit coupling by screening the calculated electronic band structure for a small gap and a change concavity at high-symmetry points. Overall, we were able to identify a number of topological candidates with varying structures and composition. Lastly, our overall goal is expand the realm of predictive theory into the determination of new and exotic complex materials through the data mining of electronic structure.

  4. Computational Search for Strong Topological Insulators: An Exercise in Data Mining and Electronic Structure

    DOE PAGES

    Klintenberg, M.; Haraldsen, Jason T.; Balatsky, Alexander V.

    2014-06-19

    In this paper, we report a data-mining investigation for the search of topological insulators by examining individual electronic structures for over 60,000 materials. Using a data-mining algorithm, we survey changes in band inversion with and without spin-orbit coupling by screening the calculated electronic band structure for a small gap and a change concavity at high-symmetry points. Overall, we were able to identify a number of topological candidates with varying structures and composition. Lastly, our overall goal is expand the realm of predictive theory into the determination of new and exotic complex materials through the data mining of electronic structure.

  5. Does topological information matter for power grid vulnerability?

    PubMed

    Ouyang, Min; Yang, Kun

    2014-12-01

    Power grids, which are playing an important role in supporting the economy of a region as well as the life of its citizens, could be attacked by terrorists or enemies to damage the region. Depending on different levels of power grid information collected by the terrorists, their attack strategies might be different. This paper groups power grid information into four levels: no information, purely topological information (PTI), topological information with generator and load nodes (GLNI), and full information (including component physical properties and flow parameters information), and then identifies possible attack strategies for each information level. Analyzing and comparing power grid vulnerability under these attack strategies from both terrorists' and utility companies' point of view give rise to an approach to quantify the relative values of these three types of information, including PTI, GLNI, and component parameter information (CPI). This approach can provide information regarding the extent to which topological information matters for power system vulnerability decisions. Taking several test systems as examples, results show that for small attacks with p ≤ 0.1, CPI matters the most; when taking attack cost into consideration and assuming that the terrorists take the optimum cost-efficient attack intensity, then CPI has the largest cost-based information value.

  6. Does topological information matter for power grid vulnerability?

    NASA Astrophysics Data System (ADS)

    Ouyang, Min; Yang, Kun

    2014-12-01

    Power grids, which are playing an important role in supporting the economy of a region as well as the life of its citizens, could be attacked by terrorists or enemies to damage the region. Depending on different levels of power grid information collected by the terrorists, their attack strategies might be different. This paper groups power grid information into four levels: no information, purely topological information (PTI), topological information with generator and load nodes (GLNI), and full information (including component physical properties and flow parameters information), and then identifies possible attack strategies for each information level. Analyzing and comparing power grid vulnerability under these attack strategies from both terrorists' and utility companies' point of view give rise to an approach to quantify the relative values of these three types of information, including PTI, GLNI, and component parameter information (CPI). This approach can provide information regarding the extent to which topological information matters for power system vulnerability decisions. Taking several test systems as examples, results show that for small attacks with p ≤ 0.1, CPI matters the most; when taking attack cost into consideration and assuming that the terrorists take the optimum cost-efficient attack intensity, then CPI has the largest cost-based information value.

  7. The topology of large-scale structure. III - Analysis of observations

    NASA Astrophysics Data System (ADS)

    Gott, J. Richard, III; Miller, John; Thuan, Trinh X.; Schneider, Stephen E.; Weinberg, David H.; Gammie, Charles; Polk, Kevin; Vogeley, Michael; Jeffrey, Scott; Bhavsar, Suketu P.; Melott, Adrian L.; Giovanelli, Riccardo; Hayes, Martha P.; Tully, R. Brent; Hamilton, Andrew J. S.

    1989-05-01

    A recently developed algorithm for quantitatively measuring the topology of large-scale structures in the universe was applied to a number of important observational data sets. The data sets included an Abell (1958) cluster sample out to Vmax = 22,600 km/sec, the Giovanelli and Haynes (1985) sample out to Vmax = 11,800 km/sec, the CfA sample out to Vmax = 5000 km/sec, the Thuan and Schneider (1988) dwarf sample out to Vmax = 3000 km/sec, and the Tully (1987) sample out to Vmax = 3000 km/sec. It was found that, when the topology is studied on smoothing scales significantly larger than the correlation length (i.e., smoothing length, lambda, not below 1200 km/sec), the topology is spongelike and is consistent with the standard model in which the structure seen today has grown from small fluctuations caused by random noise in the early universe. When the topology is studied on the scale of lambda of about 600 km/sec, a small shift is observed in the genus curve in the direction of a 'meatball' topology.

  8. Topological Isomorphisms of Human Brain and Financial Market Networks

    PubMed Central

    Vértes, Petra E.; Nicol, Ruth M.; Chapman, Sandra C.; Watkins, Nicholas W.; Robertson, Duncan A.; Bullmore, Edward T.

    2011-01-01

    Although metaphorical and conceptual connections between the human brain and the financial markets have often been drawn, rigorous physical or mathematical underpinnings of this analogy remain largely unexplored. Here, we apply a statistical and graph theoretic approach to the study of two datasets – the time series of 90 stocks from the New York stock exchange over a 3-year period, and the fMRI-derived time series acquired from 90 brain regions over the course of a 10-min-long functional MRI scan of resting brain function in healthy volunteers. Despite the many obvious substantive differences between these two datasets, graphical analysis demonstrated striking commonalities in terms of global network topological properties. Both the human brain and the market networks were non-random, small-world, modular, hierarchical systems with fat-tailed degree distributions indicating the presence of highly connected hubs. These properties could not be trivially explained by the univariate time series statistics of stock price returns. This degree of topological isomorphism suggests that brains and markets can be regarded broadly as members of the same family of networks. The two systems, however, were not topologically identical. The financial market was more efficient and more modular – more highly optimized for information processing – than the brain networks; but also less robust to systemic disintegration as a result of hub deletion. We conclude that the conceptual connections between brains and markets are not merely metaphorical; rather these two information processing systems can be rigorously compared in the same mathematical language and turn out often to share important topological properties in common to some degree. There will be interesting scientific arbitrage opportunities in further work at the graph-theoretically mediated interface between systems neuroscience and the statistical physics of financial markets. PMID:22007161

  9. A role for chromatin topology in imprinted domain regulation.

    PubMed

    MacDonald, William A; Sachani, Saqib S; White, Carlee R; Mann, Mellissa R W

    2016-02-01

    Recently, many advancements in genome-wide chromatin topology and nuclear architecture have unveiled the complex and hidden world of the nucleus, where chromatin is organized into discrete neighbourhoods with coordinated gene expression. This includes the active and inactive X chromosomes. Using X chromosome inactivation as a working model, we utilized publicly available datasets together with a literature review to gain insight into topologically associated domains, lamin-associated domains, nucleolar-associating domains, scaffold/matrix attachment regions, and nucleoporin-associated chromatin and their role in regulating monoallelic expression. Furthermore, we comprehensively review for the first time the role of chromatin topology and nuclear architecture in the regulation of genomic imprinting. We propose that chromatin topology and nuclear architecture are important regulatory mechanisms for directing gene expression within imprinted domains. Furthermore, we predict that dynamic changes in chromatin topology and nuclear architecture play roles in tissue-specific imprint domain regulation during early development and differentiation.

  10. Photoinduced Topological Phase Transitions in Topological Magnon Insulators.

    PubMed

    Owerre, S A

    2018-03-13

    Topological magnon insulators are the bosonic analogs of electronic topological insulators. They are manifested in magnetic materials with topologically nontrivial magnon bands as realized experimentally in a quasi-two-dimensional (quasi-2D) kagomé ferromagnet Cu(1-3, bdc), and they also possess protected magnon edge modes. These topological magnetic materials can transport heat as well as spin currents, hence they can be useful for spintronic applications. Moreover, as magnons are charge-neutral spin-1 bosonic quasiparticles with a magnetic dipole moment, topological magnon materials can also interact with electromagnetic fields through the Aharonov-Casher effect. In this report, we study photoinduced topological phase transitions in intrinsic topological magnon insulators in the kagomé ferromagnets. Using magnonic Floquet-Bloch theory, we show that by varying the light intensity, periodically driven intrinsic topological magnetic materials can be manipulated into different topological phases with different sign of the Berry curvatures and the thermal Hall conductivity. We further show that, under certain conditions, periodically driven gapped topological magnon insulators can also be tuned to synthetic gapless topological magnon semimetals with Dirac-Weyl magnon cones. We envision that this work will pave the way for interesting new potential practical applications in topological magnetic materials.

  11. Predictive protocol of flocks with small-world connection pattern.

    PubMed

    Zhang, Hai-Tao; Chen, Michael Z Q; Zhou, Tao

    2009-01-01

    By introducing a predictive mechanism with small-world connections, we propose a new motion protocol for self-driven flocks. The small-world connections are implemented by randomly adding long-range interactions from the leader to a few distant agents, namely, pseudoleaders. The leader can directly affect the pseudoleaders, thereby influencing all the other agents through them efficiently. Moreover, these pseudoleaders are able to predict the leader's motion several steps ahead and use this information in decision making towards coherent flocking with more stable formation. It is shown that drastic improvement can be achieved in terms of both the consensus performance and the communication cost. From the engineering point of view, the current protocol allows for a significant improvement in the cohesion and rigidity of the formation at a fairly low cost of adding a few long-range links embedded with predictive capabilities. Significantly, this work uncovers an important feature of flocks that predictive capability and long-range links can compensate for the insufficiency of each other. These conclusions are valid for both the attractive and repulsive swarm model and the Vicsek model.

  12. Structure and Topology Dynamics of Hyper-Frequency Networks during Rest and Auditory Oddball Performance.

    PubMed

    Müller, Viktor; Perdikis, Dionysios; von Oertzen, Timo; Sleimen-Malkoun, Rita; Jirsa, Viktor; Lindenberger, Ulman

    2016-01-01

    Resting-state and task-related recordings are characterized by oscillatory brain activity and widely distributed networks of synchronized oscillatory circuits. Electroencephalographic recordings (EEG) were used to assess network structure and network dynamics during resting state with eyes open and closed, and auditory oddball performance through phase synchronization between EEG channels. For this assessment, we constructed a hyper-frequency network (HFN) based on within- and cross-frequency coupling (WFC and CFC, respectively) at 10 oscillation frequencies ranging between 2 and 20 Hz. We found that CFC generally differentiates between task conditions better than WFC. CFC was the highest during resting state with eyes open. Using a graph-theoretical approach (GTA), we found that HFNs possess small-world network (SWN) topology with a slight tendency to random network characteristics. Moreover, analysis of the temporal fluctuations of HFNs revealed specific network topology dynamics (NTD), i.e., temporal changes of different graph-theoretical measures such as strength, clustering coefficient, characteristic path length (CPL), local, and global efficiency determined for HFNs at different time windows. The different topology metrics showed significant differences between conditions in the mean and standard deviation of these metrics both across time and nodes. In addition, using an artificial neural network approach, we found stimulus-related dynamics that varied across the different network topology metrics. We conclude that functional connectivity dynamics (FCD), or NTD, which was found using the HFN approach during rest and stimulus processing, reflects temporal and topological changes in the functional organization and reorganization of neuronal cell assemblies.

  13. Structure and Topology Dynamics of Hyper-Frequency Networks during Rest and Auditory Oddball Performance

    PubMed Central

    Müller, Viktor; Perdikis, Dionysios; von Oertzen, Timo; Sleimen-Malkoun, Rita; Jirsa, Viktor; Lindenberger, Ulman

    2016-01-01

    Resting-state and task-related recordings are characterized by oscillatory brain activity and widely distributed networks of synchronized oscillatory circuits. Electroencephalographic recordings (EEG) were used to assess network structure and network dynamics during resting state with eyes open and closed, and auditory oddball performance through phase synchronization between EEG channels. For this assessment, we constructed a hyper-frequency network (HFN) based on within- and cross-frequency coupling (WFC and CFC, respectively) at 10 oscillation frequencies ranging between 2 and 20 Hz. We found that CFC generally differentiates between task conditions better than WFC. CFC was the highest during resting state with eyes open. Using a graph-theoretical approach (GTA), we found that HFNs possess small-world network (SWN) topology with a slight tendency to random network characteristics. Moreover, analysis of the temporal fluctuations of HFNs revealed specific network topology dynamics (NTD), i.e., temporal changes of different graph-theoretical measures such as strength, clustering coefficient, characteristic path length (CPL), local, and global efficiency determined for HFNs at different time windows. The different topology metrics showed significant differences between conditions in the mean and standard deviation of these metrics both across time and nodes. In addition, using an artificial neural network approach, we found stimulus-related dynamics that varied across the different network topology metrics. We conclude that functional connectivity dynamics (FCD), or NTD, which was found using the HFN approach during rest and stimulus processing, reflects temporal and topological changes in the functional organization and reorganization of neuronal cell assemblies. PMID:27799906

  14. The topology of geology 1: Topological analysis

    NASA Astrophysics Data System (ADS)

    Thiele, Samuel T.; Jessell, Mark W.; Lindsay, Mark; Ogarko, Vitaliy; Wellmann, J. Florian; Pakyuz-Charrier, Evren

    2016-10-01

    Topology has been used to characterise and quantify the properties of complex systems in a diverse range of scientific domains. This study explores the concept and applications of topological analysis in geology. We have developed an automatic system for extracting first order 2D topological information from geological maps, and 3D topological information from models built with the Noddy kinematic modelling system, and equivalent analyses should be possible for other implicit modelling systems. A method is presented for describing the spatial and temporal topology of geological models using a set of adjacency relationships that can be expressed as a topology network, thematic adjacency matrix or hive diagram. We define three types of spatial topology (cellular, structural and lithological) that allow us to analyse different aspects of the geology, and then apply them to investigate the geology of the Hamersley Basin, Western Australia.

  15. Brain Graph Topology Changes Associated with Anti-Epileptic Drug Use

    PubMed Central

    Levin, Harvey S.; Chiang, Sharon

    2015-01-01

    Abstract Neuroimaging studies of functional connectivity using graph theory have furthered our understanding of the network structure in temporal lobe epilepsy (TLE). Brain network effects of anti-epileptic drugs could influence such studies, but have not been systematically studied. Resting-state functional MRI was analyzed in 25 patients with TLE using graph theory analysis. Patients were divided into two groups based on anti-epileptic medication use: those taking carbamazepine/oxcarbazepine (CBZ/OXC) (n=9) and those not taking CBZ/OXC (n=16) as a part of their medication regimen. The following graph topology metrics were analyzed: global efficiency, betweenness centrality (BC), clustering coefficient, and small-world index. Multiple linear regression was used to examine the association of CBZ/OXC with graph topology. The two groups did not differ from each other based on epilepsy characteristics. Use of CBZ/OXC was associated with a lower BC. Longer epilepsy duration was also associated with a lower BC. These findings can inform graph theory-based studies in patients with TLE. The changes observed are discussed in relation to the anti-epileptic mechanism of action and adverse effects of CBZ/OXC. PMID:25492633

  16. Identifying important nodes by adaptive LeaderRank

    NASA Astrophysics Data System (ADS)

    Xu, Shuang; Wang, Pei

    2017-03-01

    Spreading process is a common phenomenon in complex networks. Identifying important nodes in complex networks is of great significance in real-world applications. Based on the spreading process on networks, a lot of measures have been proposed to evaluate the importance of nodes. However, most of the existing measures are appropriate to static networks, which are fragile to topological perturbations. Many real-world complex networks are dynamic rather than static, meaning that the nodes and edges of such networks may change with time, which challenge numerous existing centrality measures. Based on a new weighted mechanism and the newly proposed H-index and LeaderRank (LR), this paper introduces a variant of the LR measure, called adaptive LeaderRank (ALR), which is a new member of the LR-family. Simulations on six real-world networks reveal that the new measure can well balance between prediction accuracy and robustness. More interestingly, the new measure can better adapt to the adjustment or local perturbations of network topologies, as compared with the existing measures. By discussing the detailed properties of the measures from the LR-family, we illustrate that the ALR has its competitive advantages over the other measures. The proposed algorithm enriches the measures to understand complex networks, and may have potential applications in social networks and biological systems.

  17. Circuit topology of proteins and nucleic acids.

    PubMed

    Mashaghi, Alireza; van Wijk, Roeland J; Tans, Sander J

    2014-09-02

    Folded biomolecules display a bewildering structural complexity and diversity. They have therefore been analyzed in terms of generic topological features. For instance, folded proteins may be knotted, have beta-strands arranged into a Greek-key motif, or display high contact order. In this perspective, we present a method to formally describe the topology of all folded linear chains and hence provide a general classification and analysis framework for a range of biomolecules. Moreover, by identifying the fundamental rules that intrachain contacts must obey, the method establishes the topological constraints of folded linear chains. We also briefly illustrate how this circuit topology notion can be applied to study the equivalence of folded chains, the engineering of artificial RNA structures and DNA origami, the topological structure of genomes, and the role of topology in protein folding. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Tetradymites as thermoelectrics and topological insulators

    NASA Astrophysics Data System (ADS)

    Heremans, Joseph P.; Cava, Robert J.; Samarth, Nitin

    2017-10-01

    Tetradymites are M2X3 compounds — in which M is a group V metal, usually Bi or Sb, and X is a group VI anion, Te, Se or S — that crystallize in a rhombohedral structure. Bi2Se3, Bi2Te3 and Sb2Te3 are archetypical tetradymites. Other mixtures of M and X elements produce common variants, such as Bi2Te2Se. Because tetradymites are based on heavy p-block elements, strong spin-orbit coupling greatly influences their electronic properties, both on the surface and in the bulk. Their surface electronic states are a cornerstone of frontier work on topological insulators. The bulk energy bands are characterized by small energy gaps, high group velocities, small effective masses and band inversion near the centre of the Brillouin zone. These properties are favourable for high-efficiency thermoelectric materials but make it difficult to obtain an electrically insulating bulk, which is a requirement of topological insulators. This Review outlines recent progress made in bulk and thin-film tetradymite materials for the optimization of their properties both as thermoelectrics and as topological insulators.

  19. Critical behavior of the contact process on small-world networks

    NASA Astrophysics Data System (ADS)

    Ferreira, Ronan S.; Ferreira, Silvio C.

    2013-11-01

    We investigate the role of clustering on the critical behavior of the contact process (CP) on small-world networks using the Watts-Strogatz (WS) network model with an edge rewiring probability p. The critical point is well predicted by a homogeneous cluster-approximation for the limit of vanishing clustering ( p → 1). The critical exponents and dimensionless moment ratios of the CP are in agreement with those predicted by the mean-field theory for any p > 0. This independence on the network clustering shows that the small-world property is a sufficient condition for the mean-field theory to correctly predict the universality of the model. Moreover, we compare the CP dynamics on WS networks with rewiring probability p = 1 and random regular networks and show that the weak heterogeneity of the WS network slightly changes the critical point but does not alter other critical quantities of the model.

  20. Phase Transitions of an Epidemic Spreading Model in Small-World Networks

    NASA Astrophysics Data System (ADS)

    Hua, Da-Yin; Gao, Ke

    2011-06-01

    We propose a modified susceptible-infected-refractory-susceptible (SIRS) model to investigate the global oscillations of the epidemic spreading in Watts—Strogatz (WS) small-world networks. It is found that when an individual immunity does not change or decays slowly in an immune period, the system can exhibit complex transition from an infecting stationary state to a large amplitude sustained oscillation or an absorbing state with no infection. When the immunity decays rapidly in the immune period, the transition to the global oscillation disappears and there is no oscillation. Furthermore, based on the spatio-temporal evolution patterns and the phase diagram, it is disclosed that a long immunity period takes an important role in the emergence of the global oscillation in small-world networks.

  1. Statistical mechanics of two-dimensional shuffled foams: Geometry-topology correlation in small or large disorder limits

    NASA Astrophysics Data System (ADS)

    Durand, Marc; Kraynik, Andrew M.; van Swol, Frank; Käfer, Jos; Quilliet, Catherine; Cox, Simon; Ataei Talebi, Shirin; Graner, François

    2014-06-01

    Bubble monolayers are model systems for experiments and simulations of two-dimensional packing problems of deformable objects. We explore the relation between the distributions of the number of bubble sides (topology) and the bubble areas (geometry) in the low liquid fraction limit. We use a statistical model [M. Durand, Europhys. Lett. 90, 60002 (2010), 10.1209/0295-5075/90/60002] which takes into account Plateau laws. We predict the correlation between geometrical disorder (bubble size dispersity) and topological disorder (width of bubble side number distribution) over an extended range of bubble size dispersities. Extensive data sets arising from shuffled foam experiments, surface evolver simulations, and cellular Potts model simulations all collapse surprisingly well and coincide with the model predictions, even at extremely high size dispersity. At moderate size dispersity, we recover our earlier approximate predictions [M. Durand, J. Kafer, C. Quilliet, S. Cox, S. A. Talebi, and F. Graner, Phys. Rev. Lett. 107, 168304 (2011), 10.1103/PhysRevLett.107.168304]. At extremely low dispersity, when approaching the perfectly regular honeycomb pattern, we study how both geometrical and topological disorders vanish. We identify a crystallization mechanism and explore it quantitatively in the case of bidisperse foams. Due to the deformability of the bubbles, foams can crystallize over a larger range of size dispersities than hard disks. The model predicts that the crystallization transition occurs when the ratio of largest to smallest bubble radii is 1.4.

  2. Aberrant topology of striatum's connectivity is associated with the number of episodes in depression.

    PubMed

    Meng, Chun; Brandl, Felix; Tahmasian, Masoud; Shao, Junming; Manoliu, Andrei; Scherr, Martin; Schwerthöffer, Dirk; Bäuml, Josef; Förstl, Hans; Zimmer, Claus; Wohlschläger, Afra M; Riedl, Valentin; Sorg, Christian

    2014-02-01

    In major depressive disorder, depressive episodes reoccur in ∼60% of cases; however, neural mechanisms of depressive relapse are poorly understood. Depressive episodes are characterized by aberrant topology of the brain's intrinsic functional connectivity network, and the number of episodes is one of the most important predictors for depressive relapse. In this study we hypothesized that specific changes of the topology of intrinsic connectivity interact with the course of episodes in recurrent depressive disorder. To address this hypothesis, we investigated which changes of connectivity topology are associated with the number of episodes in patients, independently of current symptoms and disease duration. Fifty subjects were recruited including 25 depressive patients (two to 10 episodes) and 25 gender- and age-matched control subjects. Resting-state functional magnetic resonance imaging, Harvard-Oxford brain atlas, wavelet-transformation of atlas-shaped regional time-series, and their pairwise Pearson's correlation were used to define individual connectivity matrices. Matrices were analysed by graph-based methods, resulting in outcome measures that were used as surrogates of intrinsic network topology. Topological scores were subsequently compared across groups, and, for patients only, related with the number of depressive episodes and current symptoms by partial correlation analysis. Concerning the whole brain connectivity network of patients, small-world topology was preserved but global efficiency was reduced and global betweenness-centrality increased. Aberrant nodal efficiency and centrality of regional connectivity was found in the dorsal striatum, inferior frontal and orbitofrontal cortex as well as in the occipital and somatosensory cortex. Inferior frontal changes were associated with current symptoms, whereas aberrant right putamen network topology was associated with the number of episodes. Results were controlled for effects of total grey matter

  3. Spectral identification of topological domains

    PubMed Central

    Chen, Jie; Hero, Alfred O.; Rajapakse, Indika

    2016-01-01

    Motivation: Topological domains have been proposed as the backbone of interphase chromosome structure. They are regions of high local contact frequency separated by sharp boundaries. Genes within a domain often have correlated transcription. In this paper, we present a computational efficient spectral algorithm to identify topological domains from chromosome conformation data (Hi-C data). We consider the genome as a weighted graph with vertices defined by loci on a chromosome and the edge weights given by interaction frequency between two loci. Laplacian-based graph segmentation is then applied iteratively to obtain the domains at the given compactness level. Comparison with algorithms in the literature shows the advantage of the proposed strategy. Results: An efficient algorithm is presented to identify topological domains from the Hi-C matrix. Availability and Implementation: The Matlab source code and illustrative examples are available at http://bionetworks.ccmb.med.umich.edu/ Contact: indikar@med.umich.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27153657

  4. Topological and trivial magnetic oscillations in nodal loop semimetals

    NASA Astrophysics Data System (ADS)

    Oroszlány, László; Dóra, Balázs; Cserti, József; Cortijo, Alberto

    2018-05-01

    Nodal loop semimetals are close descendants of Weyl semimetals and possess a topologically dressed band structure. We argue by combining the conventional theory of magnetic oscillation with topological arguments that nodal loop semimetals host coexisting topological and trivial magnetic oscillations. These originate from mapping the topological properties of the extremal Fermi surface cross sections onto the physics of two dimensional semi-Dirac systems, stemming from merging two massless Dirac cones. By tuning the chemical potential and the direction of magnetic field, a sharp transition is identified from purely trivial oscillations, arising from the Landau levels of a normal two dimensional (2D) electron gas, to a phase where oscillations of topological and trivial origin coexist, originating from 2D massless Dirac and semi-Dirac points, respectively. These could in principle be directly identified in current experiments.

  5. Foreign currency exchange network topology across the 2008 credit crisis

    NASA Astrophysics Data System (ADS)

    Sharif, Shamshuritawati; Ap, Nuraisah Che; Ruslan, Nuraimi

    2017-05-01

    A stable world currency exchange rate is a very important aspect to be considered for a developed country, i.e Malaysia. A better understanding about the currencies itself is needed nowadays. This project is about to understanding the fluctuation and to identify the most influential world currencies in the three different cases; before credit crisis, during credit crisis and after credit crisis. A network topology approach is use to examine the interrelationship between currencies based on correlation analysis. With this point of view, those relationships can be measured by a correlation structure among the currencies. The network can be analyse by filtering the important information using minimum spanning tree (MST) and interpret it using degree centrality as the centrality measure. This topology will give a useful guide to understand the behaviour and determine the most influential currency in the network as a part of a complex system. All currencies are compared among the three different cases; before credit crisis, during credit crisis and after credit crisis period. The result of this project shows that Unites State Dollar (USD), Brazilian Real (BRL), United Kingdom Pound (EUR) and Danish Krone (DKK) are the most influential currencies before the credit crisis period. With respect to during the credit crisis, New Zealand Dollar (NZD) dominates the network and it is followed by Singapore Dollar (SGD) for after the credit crisis period.

  6. Pavement cells and the topology puzzle.

    PubMed

    Carter, Ross; Sánchez-Corrales, Yara E; Hartley, Matthew; Grieneisen, Verônica A; Marée, Athanasius F M

    2017-12-01

    D'Arcy Thompson emphasised the importance of surface tension as a potential driving force in establishing cell shape and topology within tissues. Leaf epidermal pavement cells grow into jigsaw-piece shapes, highly deviating from such classical forms. We investigate the topology of developing Arabidopsis leaves composed solely of pavement cells. Image analysis of around 50,000 cells reveals a clear and unique topological signature, deviating from previously studied epidermal tissues. This topological distribution is established early during leaf development, already before the typical pavement cell shapes emerge, with topological homeostasis maintained throughout growth and unaltered between division and maturation zones. Simulating graph models, we identify a heuristic cellular division rule that reproduces the observed topology. Our parsimonious model predicts how and when cells effectively place their division plane with respect to their neighbours. We verify the predicted dynamics through in vivo tracking of 800 mitotic events, and conclude that the distinct topology is not a direct consequence of the jigsaw piece-like shape of the cells, but rather owes itself to a strongly life history-driven process, with limited impact from cell-surface mechanics. © 2017. Published by The Company of Biologists Ltd.

  7. Pavement cells and the topology puzzle

    PubMed Central

    2017-01-01

    D'Arcy Thompson emphasised the importance of surface tension as a potential driving force in establishing cell shape and topology within tissues. Leaf epidermal pavement cells grow into jigsaw-piece shapes, highly deviating from such classical forms. We investigate the topology of developing Arabidopsis leaves composed solely of pavement cells. Image analysis of around 50,000 cells reveals a clear and unique topological signature, deviating from previously studied epidermal tissues. This topological distribution is established early during leaf development, already before the typical pavement cell shapes emerge, with topological homeostasis maintained throughout growth and unaltered between division and maturation zones. Simulating graph models, we identify a heuristic cellular division rule that reproduces the observed topology. Our parsimonious model predicts how and when cells effectively place their division plane with respect to their neighbours. We verify the predicted dynamics through in vivo tracking of 800 mitotic events, and conclude that the distinct topology is not a direct consequence of the jigsaw piece-like shape of the cells, but rather owes itself to a strongly life history-driven process, with limited impact from cell-surface mechanics. PMID:29084800

  8. Localizome: a server for identifying transmembrane topologies and TM helices of eukaryotic proteins utilizing domain information

    PubMed Central

    Lee, Sunghoon; Lee, Byungwook; Jang, Insoo; Kim, Sangsoo; Bhak, Jong

    2006-01-01

    The Localizome server predicts the transmembrane (TM) helix number and TM topology of a user-supplied eukaryotic protein and presents the result as an intuitive graphic representation. It utilizes hmmpfam to detect the presence of Pfam domains and a prediction algorithm, Phobius, to predict the TM helices. The results are combined and checked against the TM topology rules stored in a protein domain database called LocaloDom. LocaloDom is a curated database that contains TM topologies and TM helix numbers of known protein domains. It was constructed from Pfam domains combined with Swiss-Prot annotations and Phobius predictions. The Localizome server corrects the combined results of the user sequence to conform to the rules stored in LocaloDom. Compared with other programs, this server showed the highest accuracy for TM topology prediction: for soluble proteins, the accuracy and coverage were 99 and 75%, respectively, while for TM protein domain regions, they were 96 and 68%, respectively. With a graphical representation of TM topology and TM helix positions with the domain units, the Localizome server is a highly accurate and comprehensive information source for subcellular localization for soluble proteins as well as membrane proteins. The Localizome server can be found at . PMID:16845118

  9. Aberrant Global and Regional Topological Organization of the Fractional Anisotropy-weighted Brain Structural Networks in Major Depressive Disorder

    PubMed Central

    Chen, Jian-Huai; Yao, Zhi-Jian; Qin, Jiao-Long; Yan, Rui; Hua, Ling-Ling; Lu, Qing

    2016-01-01

    Background: Most previous neuroimaging studies have focused on the structural and functional abnormalities of local brain regions in major depressive disorder (MDD). Moreover, the exactly topological organization of networks underlying MDD remains unclear. This study examined the aberrant global and regional topological patterns of the brain white matter networks in MDD patients. Methods: The diffusion tensor imaging data were obtained from 27 patients with MDD and 40 healthy controls. The brain fractional anisotropy-weighted structural networks were constructed, and the global network and regional nodal metrics of the networks were explored by the complex network theory. Results: Compared with the healthy controls, the brain structural network of MDD patients showed an intact small-world topology, but significantly abnormal global network topological organization and regional nodal characteristic of the network in MDD were found. Our findings also indicated that the brain structural networks in MDD patients become a less strongly integrated network with a reduced central role of some key brain regions. Conclusions: All these resulted in a less optimal topological organization of networks underlying MDD patients, including an impaired capability of local information processing, reduced centrality of some brain regions and limited capacity to integrate information across different regions. Thus, these global network and regional node-level aberrations might contribute to understanding the pathogenesis of MDD from the view of the brain network. PMID:26960371

  10. Topological Phases of Sound and Light

    NASA Astrophysics Data System (ADS)

    Peano, V.; Brendel, C.; Schmidt, M.; Marquardt, F.

    2015-07-01

    Topological states of matter are particularly robust, since they exploit global features of a material's band structure. Topological states have already been observed for electrons, atoms, and photons. It is an outstanding challenge to create a Chern insulator of sound waves in the solid state. In this work, we propose an implementation based on cavity optomechanics in a photonic crystal. The topological properties of the sound waves can be wholly tuned in situ by adjusting the amplitude and frequency of a driving laser that controls the optomechanical interaction between light and sound. The resulting chiral, topologically protected phonon transport can be probed completely optically. Moreover, we identify a regime of strong mixing between photon and phonon excitations, which gives rise to a large set of different topological phases and offers an example of a Chern insulator produced from the interaction between two physically distinct particle species, photons and phonons.

  11. The Small World of Psychopathology

    PubMed Central

    Borsboom, Denny; Cramer, Angélique O. J.; Schmittmann, Verena D.; Epskamp, Sacha; Waldorp, Lourens J.

    2011-01-01

    Background Mental disorders are highly comorbid: people having one disorder are likely to have another as well. We explain empirical comorbidity patterns based on a network model of psychiatric symptoms, derived from an analysis of symptom overlap in the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). Principal Findings We show that a) half of the symptoms in the DSM-IV network are connected, b) the architecture of these connections conforms to a small world structure, featuring a high degree of clustering but a short average path length, and c) distances between disorders in this structure predict empirical comorbidity rates. Network simulations of Major Depressive Episode and Generalized Anxiety Disorder show that the model faithfully reproduces empirical population statistics for these disorders. Conclusions In the network model, mental disorders are inherently complex. This explains the limited successes of genetic, neuroscientific, and etiological approaches to unravel their causes. We outline a psychosystems approach to investigate the structure and dynamics of mental disorders. PMID:22114671

  12. Momentum space topology of QCD

    NASA Astrophysics Data System (ADS)

    Zubkov, M. A.

    2018-06-01

    We discuss the possibility to consider quark matter as the topological material. We consider hadronic phase (HP), the quark-gluon plasma phase (QGP), and the hypothetical color-flavor locking (CFL) phase. In those phases we identify the relevant topological invariants in momentum space. The formalism is developed, which relates those invariants and massless fermions that reside on vortices and at the interphases. This formalism is illustrated by the example of vortices in the CFL phase.

  13. Effects of inspections in small world social networks with different contagion rules

    NASA Astrophysics Data System (ADS)

    Muñoz, Francisco; Nuño, Juan Carlos; Primicerio, Mario

    2015-08-01

    We study the way the structure of social links determines the effects of random inspections on a population formed by two types of individuals, e.g. tax-payers and tax-evaders (free riders). It is assumed that inspections occur in a larger scale than the population relaxation time and, therefore, a unique initial inspection is performed on a population that is completely formed by tax-evaders. Besides, the inspected tax-evaders become tax-payers forever. The social network is modeled as a Watts-Strogatz Small World whose topology can be tuned in terms of a parameter p ∈ [ 0 , 1 ] from regular (p = 0) to random (p = 1). Two local contagion rules are considered: (i) a continuous one that takes the proportion of neighbors to determine the next status of an individual (node) and (ii) a discontinuous (threshold rule) that assumes a minimum number of neighbors to modify the current state. In the former case, irrespective of the inspection intensity ν, the equilibrium population is always formed by tax-payers. In the mean field approach, we obtain the characteristic time of convergence as a function of ν and p. For the threshold contagion rule, we show that the response of the population to the intensity of inspections ν is a function of the structure of the social network p and the willingness of the individuals to change their state, r. It is shown that sharp transitions occur at critical values of ν that depends on p and r. We discuss these results within the context of tax evasion and fraud where the strategies of inspection could be of major relevance.

  14. Topological Mechanics of Origami and Kirigami

    NASA Astrophysics Data System (ADS)

    Chen, Bryan Gin-ge; Liu, Bin; Evans, Arthur A.; Paulose, Jayson; Cohen, Itai; Vitelli, Vincenzo; Santangelo, C. D.

    2016-04-01

    Origami and kirigami have emerged as potential tools for the design of mechanical metamaterials whose properties such as curvature, Poisson ratio, and existence of metastable states can be tuned using purely geometric criteria. A major obstacle to exploiting this property is the scarcity of tools to identify and program the flexibility of fold patterns. We exploit a recent connection between spring networks and quantum topological states to design origami with localized folding motions at boundaries and study them both experimentally and theoretically. These folding motions exist due to an underlying topological invariant rather than a local imbalance between constraints and degrees of freedom. We give a simple example of a quasi-1D folding pattern that realizes such topological states. We also demonstrate how to generalize these topological design principles to two dimensions. A striking consequence is that a domain wall between two topologically distinct, mechanically rigid structures is deformable even when constraints locally match the degrees of freedom.

  15. Topological superconductivity in monolayer transition metal dichalcogenides.

    PubMed

    Hsu, Yi-Ting; Vaezi, Abolhassan; Fischer, Mark H; Kim, Eun-Ah

    2017-04-11

    Theoretically, it has been known that breaking spin degeneracy and effectively realizing spinless fermions is a promising path to topological superconductors. Yet, topological superconductors are rare to date. Here we propose to realize spinless fermions by splitting the spin degeneracy in momentum space. Specifically, we identify monolayer hole-doped transition metal dichalcogenide (TMD)s as candidates for topological superconductors out of such momentum-space-split spinless fermions. Although electron-doped TMDs have recently been found superconducting, the observed superconductivity is unlikely topological because of the near spin degeneracy. Meanwhile, hole-doped TMDs with momentum-space-split spinless fermions remain unexplored. Employing a renormalization group analysis, we propose that the unusual spin-valley locking in hole-doped TMDs together with repulsive interactions selectively favours two topological superconducting states: interpocket paired state with Chern number 2 and intrapocket paired state with finite pair momentum. A confirmation of our predictions will open up possibilities for manipulating topological superconductors on the device-friendly platform of monolayer TMDs.

  16. Effects of two-dimensional magnetic uncertainties and three-dimensional error and perturbation fields on the Small Angle Slot divertor geometry and topology [Effects of two- and three-dimensional magnetic fields on the Small Angle Slot divertor magnetic topology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Trevisan, Gregorio L.; Lao, Lang L.; Evans, Todd E.

    The Small Angle Slot (SAS) was recently installed on DIII-D as an advanced divertor, promising easier plasma detachment and lower temperatures across the whole target. A twofold study of the SAS magnetic topology is presented in this paper. On one hand, a twodimensional uncertainty quantification analysis is carried out through a Monte Carlo approach in order to understand the level of accuracy of two-dimensional equilibrium computations in reconstructing the strike point and angle onto the divertor. Under typical experimental conditions, the uncertainties are found to be roughly 6.8 mm and 0.56 deg, respectively. On the other hand, a three-dimensional “vacuum”more » analysis is carried out to understand the effects of typical external perturbation fields on the scrape-off layer topology. When the threedimensional I-coils are switched on, poloidally-localized lobes are found to appear, grow, and hit the SAS target, although barely, even for 5 kA; at the same time, the strike point modulation is found to be roughly 1.8 mm and thus negligible for most purposes. Furthermore, such results complement previous two-dimensional analyses in characterizing typical SAS equilibria and provide useful background information for planning and interpreting SAS experiments.« less

  17. Effects of two-dimensional magnetic uncertainties and three-dimensional error and perturbation fields on the Small Angle Slot divertor geometry and topology [Effects of two- and three-dimensional magnetic fields on the Small Angle Slot divertor magnetic topology

    DOE PAGES

    Trevisan, Gregorio L.; Lao, Lang L.; Evans, Todd E.; ...

    2018-01-04

    The Small Angle Slot (SAS) was recently installed on DIII-D as an advanced divertor, promising easier plasma detachment and lower temperatures across the whole target. A twofold study of the SAS magnetic topology is presented in this paper. On one hand, a twodimensional uncertainty quantification analysis is carried out through a Monte Carlo approach in order to understand the level of accuracy of two-dimensional equilibrium computations in reconstructing the strike point and angle onto the divertor. Under typical experimental conditions, the uncertainties are found to be roughly 6.8 mm and 0.56 deg, respectively. On the other hand, a three-dimensional “vacuum”more » analysis is carried out to understand the effects of typical external perturbation fields on the scrape-off layer topology. When the threedimensional I-coils are switched on, poloidally-localized lobes are found to appear, grow, and hit the SAS target, although barely, even for 5 kA; at the same time, the strike point modulation is found to be roughly 1.8 mm and thus negligible for most purposes. Furthermore, such results complement previous two-dimensional analyses in characterizing typical SAS equilibria and provide useful background information for planning and interpreting SAS experiments.« less

  18. Bulk and edge spin transport in topological magnon insulators

    NASA Astrophysics Data System (ADS)

    Rückriegel, Andreas; Brataas, Arne; Duine, Rembert A.

    2018-02-01

    We investigate the spin transport properties of a topological magnon insulator, a magnetic insulator characterized by topologically nontrivial bulk magnon bands and protected magnon edge modes located in the bulk band gaps. Employing the Landau-Lifshitz-Gilbert phenomenology, we calculate the spin current driven through a normal metal |topological magnon insulator |normal metal heterostructure by a spin accumulation imbalance between the metals, with and without random lattice defects. We show that bulk and edge transport are characterized by different length scales. This results in a characteristic system size where the magnon transport crosses over from being bulk dominated for small systems to edge dominated for larger systems. These findings are generic and relevant for topological transport in systems of nonconserved bosons.

  19. Epidemics with pathogen mutation on small-world networks

    NASA Astrophysics Data System (ADS)

    Shao, Zhi-Gang; Tan, Zhi-Jie; Zou, Xian-Wu; Jin, Zhun-Zhi

    2006-05-01

    We study the dynamical behavior of the epidemiological model with pathogen mutation on small-world networks, and discuss the influence of the immunity duration τR, the cross-immunity threshold hthr, and system size N on epidemic dynamics. A decaying oscillation occurs because of the interplay between the immune response and the pathogen mutation. These results have implications for the interpretation of longitudinal epidemiological data on strain abundance, and they will be helpful to assess the threat of highly pathogenic and mutative viruses, such as avian influenza.

  20. Parameter inference in small world network disease models with approximate Bayesian Computational methods

    NASA Astrophysics Data System (ADS)

    Walker, David M.; Allingham, David; Lee, Heung Wing Joseph; Small, Michael

    2010-02-01

    Small world network models have been effective in capturing the variable behaviour of reported case data of the SARS coronavirus outbreak in Hong Kong during 2003. Simulations of these models have previously been realized using informed “guesses” of the proposed model parameters and tested for consistency with the reported data by surrogate analysis. In this paper we attempt to provide statistically rigorous parameter distributions using Approximate Bayesian Computation sampling methods. We find that such sampling schemes are a useful framework for fitting parameters of stochastic small world network models where simulation of the system is straightforward but expressing a likelihood is cumbersome.

  1. The topology of large-scale structure. III - Analysis of observations. [in universe

    NASA Technical Reports Server (NTRS)

    Gott, J. Richard, III; Weinberg, David H.; Miller, John; Thuan, Trinh X.; Schneider, Stephen E.

    1989-01-01

    A recently developed algorithm for quantitatively measuring the topology of large-scale structures in the universe was applied to a number of important observational data sets. The data sets included an Abell (1958) cluster sample out to Vmax = 22,600 km/sec, the Giovanelli and Haynes (1985) sample out to Vmax = 11,800 km/sec, the CfA sample out to Vmax = 5000 km/sec, the Thuan and Schneider (1988) dwarf sample out to Vmax = 3000 km/sec, and the Tully (1987) sample out to Vmax = 3000 km/sec. It was found that, when the topology is studied on smoothing scales significantly larger than the correlation length (i.e., smoothing length, lambda, not below 1200 km/sec), the topology is spongelike and is consistent with the standard model in which the structure seen today has grown from small fluctuations caused by random noise in the early universe. When the topology is studied on the scale of lambda of about 600 km/sec, a small shift is observed in the genus curve in the direction of a 'meatball' topology.

  2. Hybrid Topological Lie-Hamiltonian Learning in Evolving Energy Landscapes

    NASA Astrophysics Data System (ADS)

    Ivancevic, Vladimir G.; Reid, Darryn J.

    2015-11-01

    In this Chapter, a novel bidirectional algorithm for hybrid (discrete + continuous-time) Lie-Hamiltonian evolution in adaptive energy landscape-manifold is designed and its topological representation is proposed. The algorithm is developed within a geometrically and topologically extended framework of Hopfield's neural nets and Haken's synergetics (it is currently designed in Mathematica, although with small changes it could be implemented in Symbolic C++ or any other computer algebra system). The adaptive energy manifold is determined by the Hamiltonian multivariate cost function H, based on the user-defined vehicle-fleet configuration matrix W, which represents the pseudo-Riemannian metric tensor of the energy manifold. Search for the global minimum of H is performed using random signal differential Hebbian adaptation. This stochastic gradient evolution is driven (or, pulled-down) by `gravitational forces' defined by the 2nd Lie derivatives of H. Topological changes of the fleet matrix W are observed during the evolution and its topological invariant is established. The evolution stops when the W-topology breaks down into several connectivity-components, followed by topology-breaking instability sequence (i.e., a series of phase transitions).

  3. Real-space mapping of topological invariants using artificial neural networks

    NASA Astrophysics Data System (ADS)

    Carvalho, D.; García-Martínez, N. A.; Lado, J. L.; Fernández-Rossier, J.

    2018-03-01

    Topological invariants allow one to characterize Hamiltonians, predicting the existence of topologically protected in-gap modes. Those invariants can be computed by tracing the evolution of the occupied wave functions under twisted boundary conditions. However, those procedures do not allow one to calculate a topological invariant by evaluating the system locally, and thus require information about the wave functions in the whole system. Here we show that artificial neural networks can be trained to identify the topological order by evaluating a local projection of the density matrix. We demonstrate this for two different models, a one-dimensional topological superconductor and a two-dimensional quantum anomalous Hall state, both with spatially modulated parameters. Our neural network correctly identifies the different topological domains in real space, predicting the location of in-gap states. By combining a neural network with a calculation of the electronic states that uses the kernel polynomial method, we show that the local evaluation of the invariant can be carried out by evaluating a local quantity, in particular for systems without translational symmetry consisting of tens of thousands of atoms. Our results show that supervised learning is an efficient methodology to characterize the local topology of a system.

  4. Blackmail propagation on small-world networks

    NASA Astrophysics Data System (ADS)

    Shao, Zhi-Gang; Jian-Ping Sang; Zou, Xian-Wu; Tan, Zhi-Jie; Jin, Zhun-Zhi

    2005-06-01

    The dynamics of the blackmail propagation model based on small-world networks is investigated. It is found that for a given transmitting probability λ the dynamical behavior of blackmail propagation transits from linear growth type to logistical growth one with the network randomness p increases. The transition takes place at the critical network randomness pc=1/N, where N is the total number of nodes in the network. For a given network randomness p the dynamical behavior of blackmail propagation transits from exponential decrease type to logistical growth one with the transmitting probability λ increases. The transition occurs at the critical transmitting probability λc=1/, where is the average number of the nearest neighbors. The present work will be useful for understanding computer virus epidemics and other spreading phenomena on communication and social networks.

  5. Topological nonsymmorphic metals from band inversion

    DOE PAGES

    Muechler, Lukas; Alexandradinata, A.; Neupert, Titus; ...

    2016-12-29

    Here, we expand the phase diagram of two-dimensional, nonsymmorphic crystals at integer fillings that do not guarantee gaplessness. In addition to the trivial, gapped phase that is expected, we find that band inversion leads to a class of topological, gapless phases. These topological phases are exemplified by the monolayers of MTe 2 (M ¼ W; Mo) if spin-orbit coupling is neglected. We characterize the Dirac band touching of these topological metals by theWilson loop of the non-Abelian Berry gauge field. Furthermore, we develop a criterion for the proximity of these topological metals to 2D and 3D Z 2 topological insulatorsmore » when spinorbit coupling is included; our criterion is based on nonsymmorphic symmetry eigenvalues, and may be used to identify topological materials without inversion symmetry. An additional feature of the Dirac cone in monolayer MTe 2 is that it tilts over in a Lifshitz transition to produce electron and hole pockets—a type-II Dirac cone. These pockets, together with the pseudospin structure of the Dirac electrons, suggest a unified, topological explanation for the recently reported, nonsaturating magnetoresistance in WTe 2, as well as its circular dichroism in photoemission. We complement our analysis and first-principles band structure calculations with an ab-initio-derived tight-binding model for the WTe 2 monolayer.« less

  6. Anomalously small resistivity and thermopower of strongly compensated semiconductors and topological insulators

    NASA Astrophysics Data System (ADS)

    Chen, Tianran; Shklovskii, B. I.

    2013-04-01

    In the recent paper, we explained why the maximum bulk resistivity of topological insulators (TIs) such as Bi2Se3 is so small [B. Skinner, T. Chen, and B. I. Shklovskii, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.109.176801 109, 176801 (2012)]. Using the model of completely compensated semiconductor we showed that when the Fermi level is pinned in the middle of the gap the activation energy of resistivity is Δ=0.3(Eg/2), where Eg is the semiconductor gap. In this paper, we consider a strongly compensated n-type semiconductor. We find the position of the Fermi level μ calculated from the bottom of the conduction band Ec and the activation energy of resistivity Δ as a function of compensation K, and show that Δ=0.3(Ec-μ) holds at any 0<1-K≪1. In the same range of relatively high temperatures, the Peltier energy (heat) Π is even smaller: Π≃Δ/2=0.15(Ec-μ). We also show that at low temperatures, the activated conductivity crosses over to variable range hopping (VRH) and find the characteristic temperature of VRH, TES, as a function of K.

  7. Topological liquid diode

    PubMed Central

    Li, Jiaqian; Zhou, Xiaofeng; Li, Jing; Che, Lufeng; Yao, Jun; McHale, Glen; Chaudhury, Manoj K.; Wang, Zuankai

    2017-01-01

    The last two decades have witnessed an explosion of interest in the field of droplet-based microfluidics for their multifarious applications. Despite rapid innovations in strategies to generate small-scale liquid transport on these devices, the speed of motion is usually slow, the transport distance is limited, and the flow direction is not well controlled because of unwanted pinning of contact lines by defects on the surface. We report a new method of microscopic liquid transport based on a unique topological structure. This method breaks the contact line pinning through efficient conversion of excess surface energy to kinetic energy at the advancing edge of the droplet while simultaneously arresting the reverse motion of the droplet via strong pinning. This results in a novel topological fluid diode that allows for a rapid, directional, and long-distance transport of virtually any kind of liquid without the need for an external energy input. PMID:29098182

  8. Invariance of Topological Indices Under Hilbert Space Truncation

    DOE PAGES

    Huang, Zhoushen; Zhu, Wei; Arovas, Daniel P.; ...

    2018-01-05

    Here, we show that the topological index of a wave function, computed in the space of twisted boundary phases, is preserved under Hilbert space truncation, provided the truncated state remains normalizable. If truncation affects the boundary condition of the resulting state, the invariant index may acquire a different physical interpretation. If the index is symmetry protected, the truncation should preserve the protecting symmetry. We discuss implications of this invariance using paradigmatic integer and fractional Chern insulators, Z 2 topological insulators, and spin-1 Affleck-Kennedy-Lieb-Tasaki and Heisenberg chains, as well as its relation with the notion of bulk entanglement. As a possiblemore » application, we propose a partial quantum tomography scheme from which the topological index of a generic multicomponent wave function can be extracted by measuring only a small subset of wave function components, equivalent to the measurement of a bulk entanglement topological index.« less

  9. Invariance of Topological Indices Under Hilbert Space Truncation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huang, Zhoushen; Zhu, Wei; Arovas, Daniel P.

    Here, we show that the topological index of a wave function, computed in the space of twisted boundary phases, is preserved under Hilbert space truncation, provided the truncated state remains normalizable. If truncation affects the boundary condition of the resulting state, the invariant index may acquire a different physical interpretation. If the index is symmetry protected, the truncation should preserve the protecting symmetry. We discuss implications of this invariance using paradigmatic integer and fractional Chern insulators, Z 2 topological insulators, and spin-1 Affleck-Kennedy-Lieb-Tasaki and Heisenberg chains, as well as its relation with the notion of bulk entanglement. As a possiblemore » application, we propose a partial quantum tomography scheme from which the topological index of a generic multicomponent wave function can be extracted by measuring only a small subset of wave function components, equivalent to the measurement of a bulk entanglement topological index.« less

  10. Quantized transport and steady states of Floquet topological insulators

    NASA Astrophysics Data System (ADS)

    Esin, Iliya; Rudner, Mark S.; Refael, Gil; Lindner, Netanel H.

    2018-06-01

    Robust electronic edge or surface modes play key roles in the fascinating quantized responses exhibited by topological materials. Even in trivial materials, topological bands and edge states can be induced dynamically by a time-periodic drive. Such Floquet topological insulators (FTIs) inherently exist out of equilibrium; the extent to which they can host quantized transport, which depends on the steady-state population of their dynamically induced edge states, remains a crucial question. In this work, we obtain the steady states of two-dimensional FTIs in the presence of the natural dissipation mechanisms present in solid state systems. We give conditions under which the steady-state distribution resembles that of a topological insulator in the Floquet basis. In this state, the distribution in the Floquet edge modes exhibits a sharp feature akin to a Fermi level, while the bulk hosts a small density of excitations. We determine the regimes where topological edge-state transport persists and can be observed in FTIs.

  11. Topological Constraints in Directed Polymer Melts

    NASA Astrophysics Data System (ADS)

    Serna, Pablo; Bunin, Guy; Nahum, Adam

    2015-11-01

    Polymers in a melt may be subject to topological constraints, as in the example of unlinked polymer rings. How to do statistical mechanics in the presence of such constraints remains a fundamental open problem. We study the effect of topological constraints on a melt of directed polymers, using simulations of a simple quasi-2D model. We find that fixing the global topology of the melt to be trivial changes the polymer conformations drastically. Polymers of length L wander in the transverse direction only by a distance of order (ln L )ζ with ζ ≃1.5 . This is strongly suppressed in comparison with the Brownian L1 /2 scaling which holds in the absence of the topological constraint. It is also much smaller than the predictions of standard heuristic approaches—in particular the L1 /4 of a mean-field-like "array of obstacles" model—so our results present a sharp challenge to theory. Dynamics are also strongly affected by the constraints, and a tagged monomer in an infinite system performs logarithmically slow subdiffusion in the transverse direction. To cast light on the suppression of the strands' wandering, we analyze the topological complexity of subregions of the melt: the complexity is also logarithmically small, and is related to the wandering by a power law. We comment on insights the results give for 3D melts, directed and nondirected.

  12. Topological Constraints in Directed Polymer Melts.

    PubMed

    Serna, Pablo; Bunin, Guy; Nahum, Adam

    2015-11-27

    Polymers in a melt may be subject to topological constraints, as in the example of unlinked polymer rings. How to do statistical mechanics in the presence of such constraints remains a fundamental open problem. We study the effect of topological constraints on a melt of directed polymers, using simulations of a simple quasi-2D model. We find that fixing the global topology of the melt to be trivial changes the polymer conformations drastically. Polymers of length L wander in the transverse direction only by a distance of order (lnL)^{ζ} with ζ≃1.5. This is strongly suppressed in comparison with the Brownian L^{1/2} scaling which holds in the absence of the topological constraint. It is also much smaller than the predictions of standard heuristic approaches-in particular the L^{1/4} of a mean-field-like "array of obstacles" model-so our results present a sharp challenge to theory. Dynamics are also strongly affected by the constraints, and a tagged monomer in an infinite system performs logarithmically slow subdiffusion in the transverse direction. To cast light on the suppression of the strands' wandering, we analyze the topological complexity of subregions of the melt: the complexity is also logarithmically small, and is related to the wandering by a power law. We comment on insights the results give for 3D melts, directed and nondirected.

  13. Combining Topological Hardware and Topological Software: Color-Code Quantum Computing with Topological Superconductor Networks

    NASA Astrophysics Data System (ADS)

    Litinski, Daniel; Kesselring, Markus S.; Eisert, Jens; von Oppen, Felix

    2017-07-01

    We present a scalable architecture for fault-tolerant topological quantum computation using networks of voltage-controlled Majorana Cooper pair boxes and topological color codes for error correction. Color codes have a set of transversal gates which coincides with the set of topologically protected gates in Majorana-based systems, namely, the Clifford gates. In this way, we establish color codes as providing a natural setting in which advantages offered by topological hardware can be combined with those arising from topological error-correcting software for full-fledged fault-tolerant quantum computing. We provide a complete description of our architecture, including the underlying physical ingredients. We start by showing that in topological superconductor networks, hexagonal cells can be employed to serve as physical qubits for universal quantum computation, and we present protocols for realizing topologically protected Clifford gates. These hexagonal-cell qubits allow for a direct implementation of open-boundary color codes with ancilla-free syndrome read-out and logical T gates via magic-state distillation. For concreteness, we describe how the necessary operations can be implemented using networks of Majorana Cooper pair boxes, and we give a feasibility estimate for error correction in this architecture. Our approach is motivated by nanowire-based networks of topological superconductors, but it could also be realized in alternative settings such as quantum-Hall-superconductor hybrids.

  14. Long-duration transcutaneous electric acupoint stimulation alters small-world brain functional networks.

    PubMed

    Zhang, Yue; Jiang, Yin; Glielmi, Christopher B; Li, Longchuan; Hu, Xiaoping; Wang, Xiaoying; Han, Jisheng; Zhang, Jue; Cui, Cailian; Fang, Jing

    2013-09-01

    Acupuncture, which is recognized as an alternative and complementary treatment in Western medicine, has long shown efficiencies in chronic pain relief, drug addiction treatment, stroke rehabilitation and other clinical practices. The neural mechanism underlying acupuncture, however, is still unclear. Many studies have focused on the sustained effects of acupuncture on healthy subjects, yet there are very few on the topological organization of functional networks in the whole brain in response to long-duration acupuncture (longer than 20 min). This paper presents a novel study on the effects of long-duration transcutaneous electric acupoint stimulation (TEAS) on the small-world properties of brain functional networks. Functional magnetic resonance imaging was used to construct brain functional networks of 18 healthy subjects (9 males and 9 females) during the resting state. All subjects received both TEAS and minimal TEAS (MTEAS) and were scanned before and after each stimulation. An altered functional network was found with lower local efficiency and no significant change in global efficiency for healthy subjects after TEAS, while no significant difference was observed after MTEAS. The experiments also showed that the nodal efficiencies in several paralimbic/limbic regions were altered by TEAS, and those in middle frontal gyrus and other regions by MTEAS. To remove the psychological effects and the baseline, we compared the difference between diffTEAS (difference between after and before TEAS) and diffMTEAS (difference between after and before MTEAS). The results showed that the local efficiency was decreased and that the nodal efficiencies in frontal gyrus, orbitofrontal cortex, anterior cingulate gyrus and hippocampus gyrus were changed. Based on those observations, we conclude that long-duration TEAS may modulate the short-range connections of brain functional networks and also the limbic system. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Visualization of Topology through Simulation

    NASA Astrophysics Data System (ADS)

    Mulderig, Andrew; Beaucage, Gregory; Vogtt, Karsten; Jiang, Hanqiu

    Complex structures can be decomposed into their minimal topological description coupled with complications of tortuosity. We have found that a stick figure representation can account for the topological content of any structure and coupling with scaling measures of tortuosity we can reconstruct an object. This deconstruction is native to static small-angle scattering measurements where we can obtain quantitative measures of the tortuous structure and the minimal topological structure. For example, a crumpled sheet of paper is composed of a minimal sheet structure and parameters reflecting the extent of crumpling. This quantification yields information that can be used to calculate the hydrodynamic radius, radius of gyration, structural conductive pathway, modulus, and other properties of complex structures. The approach is general and has been applied to a wide range of nanostructures from crumpled graphene to branched polymers and unfolded proteins and RNA. In this poster we will demonstrate how simple structural simulations can be used to reconstruct from these parameters a 3d representation of the complex structure through a heuristic approach. Several examples will be given from nano-fractal aggregates.

  16. Areas activated during naturalistic reading comprehension overlap topological visual, auditory, and somatotomotor maps

    PubMed Central

    2016-01-01

    Abstract Cortical mapping techniques using fMRI have been instrumental in identifying the boundaries of topological (neighbor‐preserving) maps in early sensory areas. The presence of topological maps beyond early sensory areas raises the possibility that they might play a significant role in other cognitive systems, and that topological mapping might help to delineate areas involved in higher cognitive processes. In this study, we combine surface‐based visual, auditory, and somatomotor mapping methods with a naturalistic reading comprehension task in the same group of subjects to provide a qualitative and quantitative assessment of the cortical overlap between sensory‐motor maps in all major sensory modalities, and reading processing regions. Our results suggest that cortical activation during naturalistic reading comprehension overlaps more extensively with topological sensory‐motor maps than has been heretofore appreciated. Reading activation in regions adjacent to occipital lobe and inferior parietal lobe almost completely overlaps visual maps, whereas a significant portion of frontal activation for reading in dorsolateral and ventral prefrontal cortex overlaps both visual and auditory maps. Even classical language regions in superior temporal cortex are partially overlapped by topological visual and auditory maps. By contrast, the main overlap with somatomotor maps is restricted to a small region on the anterior bank of the central sulcus near the border between the face and hand representations of M‐I. Hum Brain Mapp 37:2784–2810, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. PMID:27061771

  17. Visualizing a Taxonomy for Virtual Worlds

    ERIC Educational Resources Information Center

    Downey, Steve

    2012-01-01

    Since the mid-1990s, however, the popularity, diversity, and application of virtual worlds have spread rapidly. As a result, existing taxonomies and topologies increasingly are becoming less effective at being able to classify and organize the growing diversification of content available in today's virtual worlds. This article presents the…

  18. Robust quantum network architectures and topologies for entanglement distribution

    NASA Astrophysics Data System (ADS)

    Das, Siddhartha; Khatri, Sumeet; Dowling, Jonathan P.

    2018-01-01

    Entanglement distribution is a prerequisite for several important quantum information processing and computing tasks, such as quantum teleportation, quantum key distribution, and distributed quantum computing. In this work, we focus on two-dimensional quantum networks based on optical quantum technologies using dual-rail photonic qubits for the building of a fail-safe quantum internet. We lay out a quantum network architecture for entanglement distribution between distant parties using a Bravais lattice topology, with the technological constraint that quantum repeaters equipped with quantum memories are not easily accessible. We provide a robust protocol for simultaneous entanglement distribution between two distant groups of parties on this network. We also discuss a memory-based quantum network architecture that can be implemented on networks with an arbitrary topology. We examine networks with bow-tie lattice and Archimedean lattice topologies and use percolation theory to quantify the robustness of the networks. In particular, we provide figures of merit on the loss parameter of the optical medium that depend only on the topology of the network and quantify the robustness of the network against intermittent photon loss and intermittent failure of nodes. These figures of merit can be used to compare the robustness of different network topologies in order to determine the best topology in a given real-world scenario, which is critical in the realization of the quantum internet.

  19. Generalised Sandpile Dynamics on Artificial and Real-World Directed Networks

    PubMed Central

    Zachariou, Nicky; Expert, Paul; Takayasu, Misako; Christensen, Kim

    2015-01-01

    The main finding of this paper is a novel avalanche-size exponent τ ≈ 1.87 when the generalised sandpile dynamics evolves on the real-world Japanese inter-firm network. The topology of this network is non-layered and directed, displaying the typical bow tie structure found in real-world directed networks, with cycles and triangles. We show that one can move from a strictly layered regular lattice to a more fluid structure of the inter-firm network in a few simple steps. Relaxing the regular lattice structure by introducing an interlayer distribution for the interactions, forces the scaling exponent of the avalanche-size probability density function τ out of the two-dimensional directed sandpile universality class τ = 4/3, into the mean field universality class τ = 3/2. Numerical investigation shows that these two classes are the only that exist on the directed sandpile, regardless of the underlying topology, as long as it is strictly layered. Randomly adding a small proportion of links connecting non adjacent layers in an otherwise layered network takes the system out of the mean field regime to produce non-trivial avalanche-size probability density function. Although these do not display proper scaling, they closely reproduce the behaviour observed on the Japanese inter-firm network. PMID:26606143

  20. Generalised Sandpile Dynamics on Artificial and Real-World Directed Networks.

    PubMed

    Zachariou, Nicky; Expert, Paul; Takayasu, Misako; Christensen, Kim

    2015-01-01

    The main finding of this paper is a novel avalanche-size exponent τ ≈ 1.87 when the generalised sandpile dynamics evolves on the real-world Japanese inter-firm network. The topology of this network is non-layered and directed, displaying the typical bow tie structure found in real-world directed networks, with cycles and triangles. We show that one can move from a strictly layered regular lattice to a more fluid structure of the inter-firm network in a few simple steps. Relaxing the regular lattice structure by introducing an interlayer distribution for the interactions, forces the scaling exponent of the avalanche-size probability density function τ out of the two-dimensional directed sandpile universality class τ = 4/3, into the mean field universality class τ = 3/2. Numerical investigation shows that these two classes are the only that exist on the directed sandpile, regardless of the underlying topology, as long as it is strictly layered. Randomly adding a small proportion of links connecting non adjacent layers in an otherwise layered network takes the system out of the mean field regime to produce non-trivial avalanche-size probability density function. Although these do not display proper scaling, they closely reproduce the behaviour observed on the Japanese inter-firm network.

  1. Saddle-like topological surface states on the T T'X family of compounds (T , T' = Transition metal, X =Si , Ge)

    NASA Astrophysics Data System (ADS)

    Singh, Bahadur; Zhou, Xiaoting; Lin, Hsin; Bansil, Arun

    2018-02-01

    Topological nodal-line semimetals are exotic conductors that host symmetry-protected conducting nodal lines in their bulk electronic spectrum and nontrivial drumhead states on the surface. Based on first-principles calculations and an effective model analysis, we identify the presence of topological nodal-line semimetal states in the low crystalline symmetric T T'X family of compounds (T ,T' = transition metal, X = Si or Ge) in the absence of spin-orbit coupling (SOC). Taking ZrPtGe as an exemplar system, we show that owing to small lattice symmetry this material harbors a single nodal line on the ky=0 plane with large energy dispersion and unique drumhead surface state with a saddlelike energy dispersion. When the SOC is included, the nodal line gaps out and the system transitions to a strong topological insulator state with Z2=(1 ;000 ) . The topological surface state evolves from the drumhead surface state via the sharing of its saddlelike energy dispersion within the bulk energy gap. These features differ remarkably from those of the currently known topological surface states in topological insulators such as Bi2Se3 with Dirac-cone-like energy dispersions.

  2. The brainstem reticular formation is a small-world, not scale-free, network

    PubMed Central

    Humphries, M.D; Gurney, K; Prescott, T.J

    2005-01-01

    Recently, it has been demonstrated that several complex systems may have simple graph-theoretic characterizations as so-called ‘small-world’ and ‘scale-free’ networks. These networks have also been applied to the gross neural connectivity between primate cortical areas and the nervous system of Caenorhabditis elegans. Here, we extend this work to a specific neural circuit of the vertebrate brain—the medial reticular formation (RF) of the brainstem—and, in doing so, we have made three key contributions. First, this work constitutes the first model (and quantitative review) of this important brain structure for over three decades. Second, we have developed the first graph-theoretic analysis of vertebrate brain connectivity at the neural network level. Third, we propose simple metrics to quantitatively assess the extent to which the networks studied are small-world or scale-free. We conclude that the medial RF is configured to create small-world (implying coherent rapid-processing capabilities), but not scale-free, type networks under assumptions which are amenable to quantitative measurement. PMID:16615219

  3. Agreement dynamics on interaction networks with diverse topologies

    NASA Astrophysics Data System (ADS)

    Barrat, Alain; Baronchelli, Andrea; Dall'Asta, Luca; Loreto, Vittorio

    2007-06-01

    We review the behavior of a recently introduced model of agreement dynamics, called the "Naming Game." This model describes the self-organized emergence of linguistic conventions and the establishment of simple communication systems in a population of agents with pairwise local interactions. The mechanisms of convergence towards agreement strongly depend on the network of possible interactions between the agents. In particular, the mean-field case in which all agents communicate with all the others is not efficient, since a large temporary memory is requested for the agents. On the other hand, regular lattice topologies lead to a fast local convergence but to a slow global dynamics similar to coarsening phenomena. The embedding of the agents in a small-world network represents an interesting tradeoff: a local consensus is easily reached, while the long-range links allow to bypass coarsening-like convergence. We also consider alternative adaptive strategies which can lead to faster global convergence.

  4. Coevolutionary dynamics of opinion propagation and social balance: The key role of small-worldness

    NASA Astrophysics Data System (ADS)

    Chen, Yan; Chen, Lixue; Sun, Xian; Zhang, Kai; Zhang, Jie; Li, Ping

    2014-03-01

    The propagation of various opinions in social networks, which influences human inter-relationships and even social structure, and hence is a most important part of social life. We have incorporated social balance into opinion propagation in social networks are influenced by social balance. The edges in networks can represent both friendly or hostile relations, and change with the opinions of individual nodes. We introduce a model to characterize the coevolutionary dynamics of these two dynamical processes on Watts-Strogatz (WS) small-world network. We employ two distinct evolution rules (i) opinion renewal; and (ii) relation adjustment. By changing the rewiring probability, and thus the small-worldness of the WS network, we found that the time for the system to reach balanced states depends critically on both the average path length and clustering coefficient of the network, which is different than other networked process like epidemic spreading. In particular, the system equilibrates most quickly when the underlying network demonstrates strong small-worldness, i.e., small average path lengths and large clustering coefficient. We also find that opinion clusters emerge in the process of the network approaching the global equilibrium, and a measure of global contrariety is proposed to quantify the balanced state of a social network.

  5. Exploring photonic topological insulator states in a circuit-QED lattice

    NASA Astrophysics Data System (ADS)

    Li, Jing-Ling; Shan, Chuan-Jia; Zhao, Feng

    2018-04-01

    We propose a simple protocol to explore the topological properties of photonic integer quantum Hall states in a one-dimensional circiut-QED lattice. By periodically modulating the on-site photonic energies in such a lattice, we demonstrate that this one-dimensional lattice model can be mapped into a two-dimensional integer quantum Hall insulator model. Based on the lattice-based cavity input-output theory, we show that both the photonic topological protected edge states and topological invariants can be clearly measured from the final steady state of the resonator lattice after taking into account cavity dissipation. Interestingly, we also find that the measurement signals associated with the above topological features are quite unambitious even in five coupled dissipative resonators. Our work opens up a new prospect of exploring topological states with a small-size dissipative quantum artificial lattice, which is quite attractive to the current quantum optics community.

  6. Retinal artery-vein classification via topology estimation

    PubMed Central

    Estrada, Rolando; Allingham, Michael J.; Mettu, Priyatham S.; Cousins, Scott W.; Tomasi, Carlo; Farsiu, Sina

    2015-01-01

    We propose a novel, graph-theoretic framework for distinguishing arteries from veins in a fundus image. We make use of the underlying vessel topology to better classify small and midsized vessels. We extend our previously proposed tree topology estimation framework by incorporating expert, domain-specific features to construct a simple, yet powerful global likelihood model. We efficiently maximize this model by iteratively exploring the space of possible solutions consistent with the projected vessels. We tested our method on four retinal datasets and achieved classification accuracies of 91.0%, 93.5%, 91.7%, and 90.9%, outperforming existing methods. Our results show the effectiveness of our approach, which is capable of analyzing the entire vasculature, including peripheral vessels, in wide field-of-view fundus photographs. This topology-based method is a potentially important tool for diagnosing diseases with retinal vascular manifestation. PMID:26068204

  7. Phase synchronization of bursting neurons in clustered small-world networks

    NASA Astrophysics Data System (ADS)

    Batista, C. A. S.; Lameu, E. L.; Batista, A. M.; Lopes, S. R.; Pereira, T.; Zamora-López, G.; Kurths, J.; Viana, R. L.

    2012-07-01

    We investigate the collective dynamics of bursting neurons on clustered networks. The clustered network model is composed of subnetworks, each of them presenting the so-called small-world property. This model can also be regarded as a network of networks. In each subnetwork a neuron is connected to other ones with regular as well as random connections, the latter with a given intracluster probability. Moreover, in a given subnetwork each neuron has an intercluster probability to be connected to the other subnetworks. The local neuron dynamics has two time scales (fast and slow) and is modeled by a two-dimensional map. In such small-world network the neuron parameters are chosen to be slightly different such that, if the coupling strength is large enough, there may be synchronization of the bursting (slow) activity. We give bounds for the critical coupling strength to obtain global burst synchronization in terms of the network structure, that is, the probabilities of intracluster and intercluster connections. We find that, as the heterogeneity in the network is reduced, the network global synchronizability is improved. We show that the transitions to global synchrony may be abrupt or smooth depending on the intercluster probability.

  8. Coordination sequences and information spreading in small-world networks

    NASA Astrophysics Data System (ADS)

    Herrero, Carlos P.

    2002-10-01

    We study the spread of information in small-world networks generated from different d-dimensional regular lattices, with d=1, 2, and 3. With this purpose, we analyze by numerical simulations the behavior of the coordination sequence, e.g., the average number of sites C(n) that can be reached from a given node of the network in n steps along its bonds. For sufficiently large networks, we find an asymptotic behavior C(n)~ρn, with a constant ρ that depends on the network dimension d and on the rewiring probability p (which measures the disorder strength of a given network). A simple model of information spreading in these networks is studied, assuming that only a fraction q of the network sites are active. The number of active nodes reached in n steps has an asymptotic form λn, λ being a constant that depends on p and q, as well as on the dimension d of the underlying lattice. The information spreading presents two different regimes depending on the value of λ: For λ>1 the information propagates along the whole system, and for λ<1 the spreading is damped and the information remains confined in a limited region of the network. We discuss the connection of these results with site percolation in small-world networks.

  9. On the topology of the world exchange arrangements web

    NASA Astrophysics Data System (ADS)

    Li, Xiang; Jin, Yu Ying; Chen, Guanrong

    2004-11-01

    Exchange arrangements among different countries over the world are foundations of the world economy, which generally stand behind the daily economic evolution. As the first study of the world exchange arrangements web (WEAW), we built a bipartite network with countries as one type of nodes and currencies as the other, and found it to have a prominent scale-free feature with a power-law degree distribution. In a further empirical study of the currency section of the WEAW, we calculated the clustering coefficients, average nearest-neighbors degree, and average shortest distance. As an essential economic network, the WEAW is found to be a correlated disassortative network with a hierarchical structure, possessing a more prominent scale-free feature than the world trade web (WTW).

  10. The topology of card transaction money flows

    NASA Astrophysics Data System (ADS)

    Zanin, Massimiliano; Papo, David; Romance, Miguel; Criado, Regino; Moral, Santiago

    2016-11-01

    Money flow models are essential tools to understand different economical phenomena, like saving propensities and wealth distributions. In spite of their importance, most of them are based on synthetic transaction networks with simple topologies, e.g. random or scale-free ones, as the characterisation of real networks is made difficult by the confidentiality and sensitivity of money transaction data. Here, we present an analysis of the topology created by real credit card transactions from one of the biggest world banks, and show how different distributions, e.g. number of transactions per card or amount, have nontrivial characteristics. We further describe a stochastic model to create transactions data sets, feeding from the obtained distributions, which will allow researchers to create more realistic money flow models.

  11. Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening

    PubMed Central

    Mu, Lin

    2018-01-01

    This work introduces a number of algebraic topology approaches, including multi-component persistent homology, multi-level persistent homology, and electrostatic persistence for the representation, characterization, and description of small molecules and biomolecular complexes. In contrast to the conventional persistent homology, multi-component persistent homology retains critical chemical and biological information during the topological simplification of biomolecular geometric complexity. Multi-level persistent homology enables a tailored topological description of inter- and/or intra-molecular interactions of interest. Electrostatic persistence incorporates partial charge information into topological invariants. These topological methods are paired with Wasserstein distance to characterize similarities between molecules and are further integrated with a variety of machine learning algorithms, including k-nearest neighbors, ensemble of trees, and deep convolutional neural networks, to manifest their descriptive and predictive powers for protein-ligand binding analysis and virtual screening of small molecules. Extensive numerical experiments involving 4,414 protein-ligand complexes from the PDBBind database and 128,374 ligand-target and decoy-target pairs in the DUD database are performed to test respectively the scoring power and the discriminatory power of the proposed topological learning strategies. It is demonstrated that the present topological learning outperforms other existing methods in protein-ligand binding affinity prediction and ligand-decoy discrimination. PMID:29309403

  12. Probing the Topology of Density Matrices

    NASA Astrophysics Data System (ADS)

    Bardyn, Charles-Edouard; Wawer, Lukas; Altland, Alexander; Fleischhauer, Michael; Diehl, Sebastian

    2018-01-01

    The mixedness of a quantum state is usually seen as an adversary to topological quantization of observables. For example, exact quantization of the charge transported in a so-called Thouless adiabatic pump is lifted at any finite temperature in symmetry-protected topological insulators. Here, we show that certain directly observable many-body correlators preserve the integrity of topological invariants for mixed Gaussian quantum states in one dimension. Our approach relies on the expectation value of the many-body momentum-translation operator and leads to a physical observable—the "ensemble geometric phase" (EGP)—which represents a bona fide geometric phase for mixed quantum states, in the thermodynamic limit. In cyclic protocols, the EGP provides a topologically quantized observable that detects encircled spectral singularities ("purity-gap" closing points) of density matrices. While we identify the many-body nature of the EGP as a key ingredient, we propose a conceptually simple, interferometric setup to directly measure the latter in experiments with mesoscopic ensembles of ultracold atoms.

  13. Scaling theory of topological phase transitions

    NASA Astrophysics Data System (ADS)

    Chen, Wei

    2016-02-01

    Topologically ordered systems are characterized by topological invariants that are often calculated from the momentum space integration of a certain function that represents the curvature of the many-body state. The curvature function may be Berry curvature, Berry connection, or other quantities depending on the system. Akin to stretching a messy string to reveal the number of knots it contains, a scaling procedure is proposed for the curvature function in inversion symmetric systems, from which the topological phase transition can be identified from the flow of the driving energy parameters that control the topology (hopping, chemical potential, etc) under scaling. At an infinitesimal operation, one obtains the renormalization group (RG) equations for the driving energy parameters. A length scale defined from the curvature function near the gap-closing momentum is suggested to characterize the scale invariance at critical points and fixed points, and displays a universal critical behavior in a variety of systems examined.

  14. Spacetime topology change and black hole information

    NASA Astrophysics Data System (ADS)

    Hsu, Stephen D. H.

    2007-01-01

    Topology change-the creation of a disconnected baby universe-due to black hole collapse may resolve the information loss paradox. Evolution from an early time Cauchy surface to a final surface which includes a slice of the disconnected region can be unitary and consistent with conventional quantum mechanics. We discuss the issue of cluster decomposition, showing that any violations thereof are likely to be unobservably small. Topology change is similar to the black hole remnant scenario and only requires assumptions about the behavior of quantum gravity in Planckian regimes. It does not require non-locality or any modification of low-energy physics.

  15. Corona graphs as a model of small-world networks

    NASA Astrophysics Data System (ADS)

    Lv, Qian; Yi, Yuhao; Zhang, Zhongzhi

    2015-11-01

    We introduce recursive corona graphs as a model of small-world networks. We investigate analytically the critical characteristics of the model, including order and size, degree distribution, average path length, clustering coefficient, and the number of spanning trees, as well as Kirchhoff index. Furthermore, we study the spectra for the adjacency matrix and the Laplacian matrix for the model. We obtain explicit results for all the quantities of the recursive corona graphs, which are similar to those observed in real-life networks.

  16. Topological properties of microwave magnetoelectric fields.

    PubMed

    Berezin, M; Kamenetskii, E O; Shavit, R

    2014-02-01

    Collective excitations of electron spins in a ferromagnetic sample dominated by the magnetic dipole-dipole interaction strongly influence the field structure of microwave radiation. A small quasi-two-dimensional ferrite disk with magnetic-dipolar-mode (MDM) oscillation spectra can behave as a source of specific fields in vacuum, termed magnetoelectric (ME) fields. A coupling between the time-varying electric and magnetic fields in the ME-field structures is different from such a coupling in regular electromagnetic fields. The ME fields are characterized by strong energy confinement at a subwavelength region of microwave radiation, topologically distinctive power-flow vortices, and helicity parameters [E. O. Kamenetskii, R. Joffe, and R. Shavit, Phys. Rev. E 87, 023201 (2013)]. We study topological properties of microwave ME fields by loading a MDM ferrite particle with different dielectric samples. We establish a close connection between the permittivity parameters of dielectric environment and the topology of ME fields. We show that the topology of ME fields is strongly correlated with the Fano-resonance spectra observed at terminals of a microwave structure. We reveal specific thresholds in the Fano-resonance spectra appearing at certain permittivity parameters of dielectric samples. We show that ME fields originated from MDM ferrite disks can be distinguished by topological portraits of the helicity parameters and can have a torsion degree of freedom. Importantly, the ME-field phenomena can be viewed as implementations of space-time coordinate transformations on waves.

  17. Topological Quantum Information Processing Mediated Via Hybrid Topological Insulator Structures

    DTIC Science & Technology

    2013-11-13

    manipulation, entanglement and detection ofMajorana fermions in diamond-topological insulator - superconductor heterojunctions. Furthennore, we propose to...the formation, manipulation, entanglement and detection of Majorana fermions in diamond-topological insulator - superconductor heterojunctions...Interactions between Superconductors and Topological Insulators Recent advances have revealed a new type of information processing, topological quantum

  18. Topology-function conservation in protein-protein interaction networks.

    PubMed

    Davis, Darren; Yaveroğlu, Ömer Nebil; Malod-Dognin, Noël; Stojmirovic, Aleksandar; Pržulj, Nataša

    2015-05-15

    Proteins underlay the functioning of a cell and the wiring of proteins in protein-protein interaction network (PIN) relates to their biological functions. Proteins with similar wiring in the PIN (topology around them) have been shown to have similar functions. This property has been successfully exploited for predicting protein functions. Topological similarity is also used to guide network alignment algorithms that find similarly wired proteins between PINs of different species; these similarities are used to transfer annotation across PINs, e.g. from model organisms to human. To refine these functional predictions and annotation transfers, we need to gain insight into the variability of the topology-function relationships. For example, a function may be significantly associated with specific topologies, while another function may be weakly associated with several different topologies. Also, the topology-function relationships may differ between different species. To improve our understanding of topology-function relationships and of their conservation among species, we develop a statistical framework that is built upon canonical correlation analysis. Using the graphlet degrees to represent the wiring around proteins in PINs and gene ontology (GO) annotations to describe their functions, our framework: (i) characterizes statistically significant topology-function relationships in a given species, and (ii) uncovers the functions that have conserved topology in PINs of different species, which we term topologically orthologous functions. We apply our framework to PINs of yeast and human, identifying seven biological process and two cellular component GO terms to be topologically orthologous for the two organisms. © The Author 2015. Published by Oxford University Press.

  19. Topological Insulators in Ternary Compounds with a Honeycomb Lattice

    NASA Astrophysics Data System (ADS)

    Zhang, Hai-Jun; Chadov, Stanislav; Müchler, Lukas; Yan, Binghai; Qi, Xiao-Liang; Kübler, Jürgen; Zhang, Shou-Cheng; Felser, Claudia

    2011-04-01

    We investigate a new class of ternary materials such as LiAuSe and KHgSb with a honeycomb structure in Au-Se and Hg-Sb layers. We demonstrate the band inversion in these materials similar to HgTe, which is a strong precondition for existence of the topological surface states. In contrast with graphene, these materials exhibit strong spin-orbit coupling and a small direct band gap at the Γ point. Since these materials are centrosymmetric, it is straightforward to determine the parity of their wave functions, and hence their topological character. Surprisingly, the compound with strong spin-orbit coupling (KHgSb) is trivial, whereas LiAuSe is found to be a topological insulator.

  20. Revealing topological organization of human brain functional networks with resting-state functional near infrared spectroscopy.

    PubMed

    Niu, Haijing; Wang, Jinhui; Zhao, Tengda; Shu, Ni; He, Yong

    2012-01-01

    The human brain is a highly complex system that can be represented as a structurally interconnected and functionally synchronized network, which assures both the segregation and integration of information processing. Recent studies have demonstrated that a variety of neuroimaging and neurophysiological techniques such as functional magnetic resonance imaging (MRI), diffusion MRI and electroencephalography/magnetoencephalography can be employed to explore the topological organization of human brain networks. However, little is known about whether functional near infrared spectroscopy (fNIRS), a relatively new optical imaging technology, can be used to map functional connectome of the human brain and reveal meaningful and reproducible topological characteristics. We utilized resting-state fNIRS (R-fNIRS) to investigate the topological organization of human brain functional networks in 15 healthy adults. Brain networks were constructed by thresholding the temporal correlation matrices of 46 channels and analyzed using graph-theory approaches. We found that the functional brain network derived from R-fNIRS data had efficient small-world properties, significant hierarchical modular structure and highly connected hubs. These results were highly reproducible both across participants and over time and were consistent with previous findings based on other functional imaging techniques. Our results confirmed the feasibility and validity of using graph-theory approaches in conjunction with optical imaging techniques to explore the topological organization of human brain networks. These results may expand a methodological framework for utilizing fNIRS to study functional network changes that occur in association with development, aging and neurological and psychiatric disorders.

  1. Intelsat's small earth stations - Impact on the developing world

    NASA Astrophysics Data System (ADS)

    McDougal, Patrick

    1986-12-01

    This article offers a brief historical look at the progress in the use of small earth stations in the developing world, and a present status report on Intelsat's new service offerings, especially in the use of smaller earth station technology. Three experiments or series of experiments are discussed: those conducted on NASA's ATS (Applications Technology Satellite) series of satellites, India's SITE (Satellite Instructional Television Experiment), and the Rural Satellite Project sponsored by the U.S. Agency for International Development. Intelsat's contributions to the growth of telecommunications in the developing world include: domestic leases, VISTA and INTELNET services, Project SHARE, and some new strategies for the financing of telecommunications projects. The article concludes that it is only recently that some of the true benefits of satellite communications have been realized in the developing countries because of improvements in technology, reduction in costs, and diversity of service offerings.

  2. Diagnosing Topological Edge States via Entanglement Monogamy.

    PubMed

    Meichanetzidis, K; Eisert, J; Cirio, M; Lahtinen, V; Pachos, J K

    2016-04-01

    Topological phases of matter possess intricate correlation patterns typically probed by entanglement entropies or entanglement spectra. In this Letter, we propose an alternative approach to assessing topologically induced edge states in free and interacting fermionic systems. We do so by focussing on the fermionic covariance matrix. This matrix is often tractable either analytically or numerically, and it precisely captures the relevant correlations of the system. By invoking the concept of monogamy of entanglement, we show that highly entangled states supported across a system bipartition are largely disentangled from the rest of the system, thus, usually appearing as gapless edge states. We then define an entanglement qualifier that identifies the presence of topological edge states based purely on correlations present in the ground states. We demonstrate the versatility of this qualifier by applying it to various free and interacting fermionic topological systems.

  3. Diagnosing Topological Edge States via Entanglement Monogamy

    NASA Astrophysics Data System (ADS)

    Meichanetzidis, K.; Eisert, J.; Cirio, M.; Lahtinen, V.; Pachos, J. K.

    2016-04-01

    Topological phases of matter possess intricate correlation patterns typically probed by entanglement entropies or entanglement spectra. In this Letter, we propose an alternative approach to assessing topologically induced edge states in free and interacting fermionic systems. We do so by focussing on the fermionic covariance matrix. This matrix is often tractable either analytically or numerically, and it precisely captures the relevant correlations of the system. By invoking the concept of monogamy of entanglement, we show that highly entangled states supported across a system bipartition are largely disentangled from the rest of the system, thus, usually appearing as gapless edge states. We then define an entanglement qualifier that identifies the presence of topological edge states based purely on correlations present in the ground states. We demonstrate the versatility of this qualifier by applying it to various free and interacting fermionic topological systems.

  4. Topological magnetoelectric pump in three dimensions

    NASA Astrophysics Data System (ADS)

    Fukui, Takahiro; Fujiwara, Takanori

    2017-11-01

    We study the topological pump for a lattice fermion model mainly in three spatial dimensions. We first calculate the U(1) current density for the Dirac model defined in continuous space-time to review the known results as well as to introduce some technical details convenient for the calculations of the lattice model. We next investigate the U(1) current density for a lattice fermion model, a variant of the Wilson-Dirac model. The model we introduce is defined on a lattice in space but in continuous time, which is suited for the study of the topological pump. For such a model, we derive the conserved U(1) current density and calculate it directly for the (1 +1 )-dimensional system as well as (3 +1 )-dimensional system in the limit of the small lattice constant. We find that the current includes a nontrivial lattice effect characterized by the Chern number, and therefore the pumped particle number is quantized by the topological reason. Finally, we study the topological temporal pump in 3 +1 dimensions by numerical calculations. We discuss the relationship between the second Chern number and the first Chern number, the bulk-edge correspondence, and the generalized Streda formula which enables us to compute the second Chern number using the spectral asymmetry.

  5. Prediction of weak and strong topological insulators in layered semiconductors.

    NASA Astrophysics Data System (ADS)

    Felser, Claudia

    2013-03-01

    We investigate a new class of ternary materials such as LiAuSe and KHgSb with a honeycomb structure in Au-Se and Hg-Sb layers. We demonstrate the band inversion in these materials similar to HgTe, which is a strong precondition for existence of the topological surface states. In contrast with graphene, these materials exhibit strong spin-orbit coupling and a small direct band gap at the point. Since these materials are centrosymmetric, it is straightforward to determine the parity of their wave functions, and hence their topological character. Surprisingly, the compound with strong spin-orbit coupling (KHgSb) is trivial, whereas LiAuSe is found to be a topological insulator. However KHgSb is a weak topological insulators in case of an odd number of layers in the primitive unit cell. Here, the single-layered KHgSb shows a large bulk energy gap of 0.24 eV. Its side surface hosts metallic surface states, forming two anisotropic Dirac cones. Although the stacking of even-layered structures leads to trivial insulators, the structures can host a quantum spin Hall layer with a large bulk gap, if an additional single layer exists as a stacking fault in the crystal. The reported honeycomb compounds can serve as prototypes to aid in the finding of new weak topological insulators in layered small-gap semiconductors. In collaboration with Binghai Yan, Lukas Müchler, Hai-Jun Zhang, Shou-Cheng Zhang and Jürgen Kübler.

  6. Topological framework for local structure analysis in condensed matter

    PubMed Central

    Lazar, Emanuel A.; Han, Jian; Srolovitz, David J.

    2015-01-01

    Physical systems are frequently modeled as sets of points in space, each representing the position of an atom, molecule, or mesoscale particle. As many properties of such systems depend on the underlying ordering of their constituent particles, understanding that structure is a primary objective of condensed matter research. Although perfect crystals are fully described by a set of translation and basis vectors, real-world materials are never perfect, as thermal vibrations and defects introduce significant deviation from ideal order. Meanwhile, liquids and glasses present yet more complexity. A complete understanding of structure thus remains a central, open problem. Here we propose a unified mathematical framework, based on the topology of the Voronoi cell of a particle, for classifying local structure in ordered and disordered systems that is powerful and practical. We explain the underlying reason why this topological description of local structure is better suited for structural analysis than continuous descriptions. We demonstrate the connection of this approach to the behavior of physical systems and explore how crystalline structure is compromised at elevated temperatures. We also illustrate potential applications to identifying defects in plastically deformed polycrystals at high temperatures, automating analysis of complex structures, and characterizing general disordered systems. PMID:26460045

  7. Cardiac magnetic field map topology quantified by Kullback-Leibler entropy identifies patients with hypertrophic cardiomyopathy

    NASA Astrophysics Data System (ADS)

    Schirdewan, A.; Gapelyuk, A.; Fischer, R.; Koch, L.; Schütt, H.; Zacharzowsky, U.; Dietz, R.; Thierfelder, L.; Wessel, N.

    2007-03-01

    Hypertrophic cardiomyopathy (HCM) is a common primary inherited cardiac muscle disorder, defined clinically by the presence of unexplained left ventricular hypertrophy. The detection of affected patients remains challenging. Genetic testing is limited because only in 50%-60% of all HCM diagnoses an underlying mutation can be found. Furthermore, the disease has a varied clinical course and outcome, with many patients having little or no discernible cardiovascular symptoms, whereas others develop profound exercise limitation and recurrent arrhythmias or sudden cardiac death. Therefore prospective screening of HCM family members is strongly recommended. According to the current guidelines this includes serial echocardiographic and electrocardiographic examinations. In this study we investigated the capability of cardiac magnetic field mapping (CMFM) to detect patients suffering from HCM. We introduce for the first time a combined diagnostic approach based on map topology quantification using Kullback-Leibler (KL) entropy and regional magnetic field strength parameters. The cardiac magnetic field was recorded over the anterior chest wall using a multichannel-LT-SQUID system. CMFM was calculated based on a regular 36 point grid. We analyzed CMFM in patients with confirmed diagnosis of HCM (HCM, n =33, 43.8±13 years, 13 women, 20 men), a control group of healthy subjects (NORMAL, n =57, 39.6±8.9 years; 22 women and 35 men), and patients with confirmed cardiac hypertrophy due to arterial hypertension (HYP, n =42, 49.7±7.9 years, 15 women and 27 men). A subgroup analysis was performed between HCM patients suffering from the obstructive (HOCM, n =19) and nonobstructive (HNCM, n =14) form of the disease. KL entropy based map topology quantification alone identified HCM patients with a sensitivity of 78.8% and specificity of 86.9% (overall classification rate 84.8%). The combination of the KL parameters with a regional field strength parameter improved the overall

  8. Areas activated during naturalistic reading comprehension overlap topological visual, auditory, and somatotomotor maps.

    PubMed

    Sood, Mariam R; Sereno, Martin I

    2016-08-01

    Cortical mapping techniques using fMRI have been instrumental in identifying the boundaries of topological (neighbor-preserving) maps in early sensory areas. The presence of topological maps beyond early sensory areas raises the possibility that they might play a significant role in other cognitive systems, and that topological mapping might help to delineate areas involved in higher cognitive processes. In this study, we combine surface-based visual, auditory, and somatomotor mapping methods with a naturalistic reading comprehension task in the same group of subjects to provide a qualitative and quantitative assessment of the cortical overlap between sensory-motor maps in all major sensory modalities, and reading processing regions. Our results suggest that cortical activation during naturalistic reading comprehension overlaps more extensively with topological sensory-motor maps than has been heretofore appreciated. Reading activation in regions adjacent to occipital lobe and inferior parietal lobe almost completely overlaps visual maps, whereas a significant portion of frontal activation for reading in dorsolateral and ventral prefrontal cortex overlaps both visual and auditory maps. Even classical language regions in superior temporal cortex are partially overlapped by topological visual and auditory maps. By contrast, the main overlap with somatomotor maps is restricted to a small region on the anterior bank of the central sulcus near the border between the face and hand representations of M-I. Hum Brain Mapp 37:2784-2810, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

  9. Spatial prisoner's dilemma game with volunteering in Newman-Watts small-world networks

    NASA Astrophysics Data System (ADS)

    Wu, Zhi-Xi; Xu, Xin-Jian; Chen, Yong; Wang, Ying-Hai

    2005-03-01

    A modified spatial prisoner’s dilemma game with voluntary participation in Newman-Watts small-world networks is studied. Some reasonable ingredients are introduced to the game evolutionary dynamics: each agent in the network is a pure strategist and can only take one of three strategies (cooperator, defector, and loner); its strategical transformation is associated with both the number of strategical states and the magnitude of average profits, which are adopted and acquired by its coplayers in the previous round of play; a stochastic strategy mutation is applied when it gets into the trouble of local commons that the agent and its neighbors are in the same state and get the same average payoffs. In the case of very low temptation to defect, it is found that agents are willing to participate in the game in typical small-world region and intensive collective oscillations arise in more random region.

  10. Constructing a Watts-Strogatz network from a small-world network with symmetric degree distribution.

    PubMed

    Menezes, Mozart B C; Kim, Seokjin; Huang, Rongbing

    2017-01-01

    Though the small-world phenomenon is widespread in many real networks, it is still challenging to replicate a large network at the full scale for further study on its structure and dynamics when sufficient data are not readily available. We propose a method to construct a Watts-Strogatz network using a sample from a small-world network with symmetric degree distribution. Our method yields an estimated degree distribution which fits closely with that of a Watts-Strogatz network and leads into accurate estimates of network metrics such as clustering coefficient and degree of separation. We observe that the accuracy of our method increases as network size increases.

  11. Topological Gyroscopic Metamaterials

    NASA Astrophysics Data System (ADS)

    Nash, Lisa Michelle

    Topological materials are generally insulating in their bulk, with protected conducting states on their boundaries that are robust against disorder and perturbation of material property. The existence of these conducting edge states is characterized by an integer topological invariant. Though the phenomenon was first discovered in electronic systems, recent years have shown that topological states exist in classical systems as well. In this thesis we are primarily concerned with the topological properties of gyroscopic materials, which are created by coupling networks of fast-spinning objects. Through a series of simulations, numerical calculations, and experiments, we show that these materials can support topological edge states. We find that edge states in these gyroscopic metamaterials bear the hallmarks of topology related to broken time reversal symmetry: they transmit excitations unidirectionally and are extremely robust against experimental disorder. We also explore requirements for topology by studying several lattice configurations and find that topology emerges naturally in gyroscopic systems.A simple prescription can be used to create many gyroscopic lattices. Though many of our gyroscopic networks are periodic, we explore amorphous point-sets and find that topology also emerges in these networks.

  12. Polydispersity-driven topological defects as order-restoring excitations.

    PubMed

    Yao, Zhenwei; Olvera de la Cruz, Monica

    2014-04-08

    The engineering of defects in crystalline matter has been extensively exploited to modify the mechanical and electrical properties of many materials. Recent experiments on manipulating extended defects in graphene, for example, show that defects direct the flow of electric charges. The fascinating possibilities offered by defects in two dimensions, known as topological defects, to control material properties provide great motivation to perform fundamental investigations to uncover their role in various systems. Previous studies mostly focus on topological defects in 2D crystals on curved surfaces. On flat geometries, topological defects can be introduced via density inhomogeneities. We investigate here topological defects due to size polydispersity on flat surfaces. Size polydispersity is usually an inevitable feature of a large variety of systems. In this work, simulations show well-organized induced topological defects around an impurity particle of a wrong size. These patterns are not found in systems of identical particles. Our work demonstrates that in polydispersed systems topological defects play the role of restoring order. The simulations show a perfect hexagonal lattice beyond a small defective region around the impurity particle. Elasticity theory has demonstrated an analogy between the elementary topological defects named disclinations to electric charges by associating a charge to a disclination, whose sign depends on the number of its nearest neighbors. Size polydispersity is shown numerically here to be an essential ingredient to understand short-range attractions between like-charge disclinations. Our study suggests that size polydispersity has a promising potential to engineer defects in various systems including nanoparticles and colloidal crystals.

  13. Hopf-link topological nodal-loop semimetals

    NASA Astrophysics Data System (ADS)

    Zhou, Yao; Xiong, Feng; Wan, Xiangang; An, Jin

    2018-04-01

    We construct a generic two-band model which can describe topological semimetals with multiple closed nodal loops. All the existing multi-nodal-loop semimetals, including the nodal-net, nodal-chain, and Hopf-link states, can be examined within the same framework. Based on a two-nodal-loop model, the corresponding drumhead surface states for these topologically different bulk states are studied and compared with each other. The connection of our model with Hopf insulators is also discussed. Furthermore, to identify experimentally these topologically different semimetal states, especially to distinguish the Hopf-link from unlinked ones, we also investigate their Landau levels. It is found that the Hopf-link state can be characterized by the existence of a quadruply degenerate zero-energy Landau band, regardless of the direction of the magnetic field.

  14. Spin-polarized surface resonances accompanying topological surface state formation

    DOE PAGES

    Jozwiak, Chris; Sobota, Jonathan A.; Gotlieb, Kenneth; ...

    2016-10-14

    Topological insulators host spin-polarized surface states born out of the energetic inversion of bulk bands driven by the spin-orbit interaction. Here we discover previously unidentified consequences of band-inversion on the surface electronic structure of the topological insulator Bi 2Se 3. By performing simultaneous spin, time, and angle-resolved photoemission spectroscopy, we map the spin-polarized unoccupied electronic structure and identify a surface resonance which is distinct from the topological surface state, yet shares a similar spin-orbital texture with opposite orientation. Its momentum dependence and spin texture imply an intimate connection with the topological surface state. Calculations show these two distinct states canmore » emerge from trivial Rashba-like states that change topology through the spin-orbit-induced band inversion. As a result, this work thus provides a compelling view of the coevolution of surface states through a topological phase transition, enabled by the unique capability of directly measuring the spin-polarized unoccupied band structure.« less

  15. Spin-polarized surface resonances accompanying topological surface state formation

    PubMed Central

    Jozwiak, Chris; Sobota, Jonathan A.; Gotlieb, Kenneth; Kemper, Alexander F.; Rotundu, Costel R.; Birgeneau, Robert J.; Hussain, Zahid; Lee, Dung-Hai; Shen, Zhi-Xun; Lanzara, Alessandra

    2016-01-01

    Topological insulators host spin-polarized surface states born out of the energetic inversion of bulk bands driven by the spin-orbit interaction. Here we discover previously unidentified consequences of band-inversion on the surface electronic structure of the topological insulator Bi2Se3. By performing simultaneous spin, time, and angle-resolved photoemission spectroscopy, we map the spin-polarized unoccupied electronic structure and identify a surface resonance which is distinct from the topological surface state, yet shares a similar spin-orbital texture with opposite orientation. Its momentum dependence and spin texture imply an intimate connection with the topological surface state. Calculations show these two distinct states can emerge from trivial Rashba-like states that change topology through the spin-orbit-induced band inversion. This work thus provides a compelling view of the coevolution of surface states through a topological phase transition, enabled by the unique capability of directly measuring the spin-polarized unoccupied band structure. PMID:27739428

  16. Brane-world motion in compact dimensions

    NASA Astrophysics Data System (ADS)

    Greene, Brian; Levin, Janna; Parikh, Maulik

    2011-08-01

    The topology of extra dimensions can break global Lorentz invariance, singling out a globally preferred frame even in flat spacetime. Through experiments that probe global topology, an observer can determine her state of motion with respect to the preferred frame. This scenario is realized if we live on a brane universe moving through a flat space with compact extra dimensions. We identify three experimental effects due to the motion of our universe that one could potentially detect using gravitational probes. One of these relates to the peculiar properties of the twin paradox in multiply-connected spacetimes. Another relies on the fact that the Kaluza-Klein modes of any bulk field are sensitive to boundary conditions. A third concerns the modification to the Newtonian potential on a moving brane. Remarkably, we find that even small extra dimensions are detectable by brane observers if the brane is moving sufficiently fast. Communicated by P R L V Moniz

  17. Topology for efficient information dissemination in ad-hoc networking

    NASA Technical Reports Server (NTRS)

    Jennings, E.; Okino, C. M.

    2002-01-01

    In this paper, we explore the information dissemination problem in ad-hoc wirless networks. First, we analyze the probability of successful broadcast, assuming: the nodes are uniformly distributed, the available area has a lower bould relative to the total number of nodes, and there is zero knowledge of the overall topology of the network. By showing that the probability of such events is small, we are motivated to extract good graph topologies to minimize the overall transmissions. Three algorithms are used to generate topologies of the network with guaranteed connectivity. These are the minimum radius graph, the relative neighborhood graph and the minimum spanning tree. Our simulation shows that the relative neighborhood graph has certain good graph properties, which makes it suitable for efficient information dissemination.

  18. Classification of complex networks based on similarity of topological network features

    NASA Astrophysics Data System (ADS)

    Attar, Niousha; Aliakbary, Sadegh

    2017-09-01

    Over the past few decades, networks have been widely used to model real-world phenomena. Real-world networks exhibit nontrivial topological characteristics and therefore, many network models are proposed in the literature for generating graphs that are similar to real networks. Network models reproduce nontrivial properties such as long-tail degree distributions or high clustering coefficients. In this context, we encounter the problem of selecting the network model that best fits a given real-world network. The need for a model selection method reveals the network classification problem, in which a target-network is classified into one of the candidate network models. In this paper, we propose a novel network classification method which is independent of the network size and employs an alignment-free metric of network comparison. The proposed method is based on supervised machine learning algorithms and utilizes the topological similarities of networks for the classification task. The experiments show that the proposed method outperforms state-of-the-art methods with respect to classification accuracy, time efficiency, and robustness to noise.

  19. Topological Organization of Functional Brain Networks in Healthy Children: Differences in Relation to Age, Sex, and Intelligence

    PubMed Central

    Wu, Kai; Taki, Yasuyuki; Sato, Kazunori; Hashizume, Hiroshi; Sassa, Yuko; Takeuchi, Hikaru; Thyreau, Benjamin; He, Yong; Evans, Alan C.; Li, Xiaobo; Kawashima, Ryuta; Fukuda, Hiroshi

    2013-01-01

    Recent studies have demonstrated developmental changes of functional brain networks derived from functional connectivity using graph theoretical analysis, which has been rapidly translated to studies of brain network organization. However, little is known about sex- and IQ-related differences in the topological organization of functional brain networks during development. In this study, resting-state fMRI (rs-fMRI) was used to map the functional brain networks in 51 healthy children. We then investigated the effects of age, sex, and IQ on economic small-world properties and regional nodal properties of the functional brain networks. At a global level of whole networks, we found significant age-related increases in the small-worldness and local efficiency, significant higher values of the global efficiency in boys compared with girls, and no significant IQ-related difference. Age-related increases in the regional nodal properties were found predominately in the frontal brain regions, whereas the parietal, temporal, and occipital brain regions showed age-related decreases. Significant sex-related differences in the regional nodal properties were found in various brain regions, primarily related to the default mode, language, and vision systems. Positive correlations between IQ and the regional nodal properties were found in several brain regions related to the attention system, whereas negative correlations were found in various brain regions primarily involved in the default mode, emotion, and language systems. Together, our findings of the network topology of the functional brain networks in healthy children and its relationship with age, sex, and IQ bring new insights into the understanding of brain maturation and cognitive development during childhood and adolescence. PMID:23390528

  20. Topological organization of functional brain networks in healthy children: differences in relation to age, sex, and intelligence.

    PubMed

    Wu, Kai; Taki, Yasuyuki; Sato, Kazunori; Hashizume, Hiroshi; Sassa, Yuko; Takeuchi, Hikaru; Thyreau, Benjamin; He, Yong; Evans, Alan C; Li, Xiaobo; Kawashima, Ryuta; Fukuda, Hiroshi

    2013-01-01

    Recent studies have demonstrated developmental changes of functional brain networks derived from functional connectivity using graph theoretical analysis, which has been rapidly translated to studies of brain network organization. However, little is known about sex- and IQ-related differences in the topological organization of functional brain networks during development. In this study, resting-state fMRI (rs-fMRI) was used to map the functional brain networks in 51 healthy children. We then investigated the effects of age, sex, and IQ on economic small-world properties and regional nodal properties of the functional brain networks. At a global level of whole networks, we found significant age-related increases in the small-worldness and local efficiency, significant higher values of the global efficiency in boys compared with girls, and no significant IQ-related difference. Age-related increases in the regional nodal properties were found predominately in the frontal brain regions, whereas the parietal, temporal, and occipital brain regions showed age-related decreases. Significant sex-related differences in the regional nodal properties were found in various brain regions, primarily related to the default mode, language, and vision systems. Positive correlations between IQ and the regional nodal properties were found in several brain regions related to the attention system, whereas negative correlations were found in various brain regions primarily involved in the default mode, emotion, and language systems. Together, our findings of the network topology of the functional brain networks in healthy children and its relationship with age, sex, and IQ bring new insights into the understanding of brain maturation and cognitive development during childhood and adolescence.

  1. A toolbox model of evolution of metabolic pathways on networks of arbitrary topology.

    PubMed

    Pang, Tin Yau; Maslov, Sergei

    2011-05-01

    In prokaryotic genomes the number of transcriptional regulators is known to be proportional to the square of the total number of protein-coding genes. A toolbox model of evolution was recently proposed to explain this empirical scaling for metabolic enzymes and their regulators. According to its rules, the metabolic network of an organism evolves by horizontal transfer of pathways from other species. These pathways are part of a larger "universal" network formed by the union of all species-specific networks. It remained to be understood, however, how the topological properties of this universal network influence the scaling law of functional content of genomes in the toolbox model. Here we answer this question by first analyzing the scaling properties of the toolbox model on arbitrary tree-like universal networks. We prove that critical branching topology, in which the average number of upstream neighbors of a node is equal to one, is both necessary and sufficient for quadratic scaling. We further generalize the rules of the model to incorporate reactions with multiple substrates/products as well as branched and cyclic metabolic pathways. To achieve its metabolic tasks, the new model employs evolutionary optimized pathways with minimal number of reactions. Numerical simulations of this realistic model on the universal network of all reactions in the KEGG database produced approximately quadratic scaling between the number of regulated pathways and the size of the metabolic network. To quantify the geometrical structure of individual pathways, we investigated the relationship between their number of reactions, byproducts, intermediate, and feedback metabolites. Our results validate and explain the ubiquitous appearance of the quadratic scaling for a broad spectrum of topologies of underlying universal metabolic networks. They also demonstrate why, in spite of "small-world" topology, real-life metabolic networks are characterized by a broad distribution of pathway

  2. The architecture of dynamic reservoir in the echo state network

    NASA Astrophysics Data System (ADS)

    Cui, Hongyan; Liu, Xiang; Li, Lixiang

    2012-09-01

    Echo state network (ESN) has recently attracted increasing interests because of its superior capability in modeling nonlinear dynamic systems. In the conventional echo state network model, its dynamic reservoir (DR) has a random and sparse topology, which is far from the real biological neural networks from both structural and functional perspectives. We hereby propose three novel types of echo state networks with new dynamic reservoir topologies based on complex network theory, i.e., with a small-world topology, a scale-free topology, and a mixture of small-world and scale-free topologies, respectively. We then analyze the relationship between the dynamic reservoir structure and its prediction capability. We utilize two commonly used time series to evaluate the prediction performance of the three proposed echo state networks and compare them to the conventional model. We also use independent and identically distributed time series to analyze the short-term memory and prediction precision of these echo state networks. Furthermore, we study the ratio of scale-free topology and the small-world topology in the mixed-topology network, and examine its influence on the performance of the echo state networks. Our simulation results show that the proposed echo state network models have better prediction capabilities, a wider spectral radius, but retain almost the same short-term memory capacity as compared to the conventional echo state network model. We also find that the smaller the ratio of the scale-free topology over the small-world topology, the better the memory capacities.

  3. Manipulating topological states by imprinting non-collinear spin textures

    DOE PAGES

    Streubel, Robert; Han, Luyang; Im, Mi -Young; ...

    2015-03-05

    Topological magnetic states, such as chiral skyrmions, are of great scientific interest and show huge potential for novel spintronics applications, provided their topological charges can be fully controlled. So far skyrmionic textures have been observed in noncentrosymmetric crystalline materials with low symmetry and at low temperatures. We propose theoretically and demonstrate experimentally the design of spin textures with topological charge densities that can be tailored at ambient temperatures. Tuning the interlayer coupling in vertically stacked nanopatterned magnetic heterostructures, such as a model system of a Co/Pd multilayer coupled to Permalloy, the in-plane non-collinear spin texture of one layer can bemore » imprinted into the out-of-plane magnetised material. We observe distinct spin textures, e.g. vortices, magnetic swirls with tunable opening angle, donut states and skyrmion core configurations. We show that applying a small magnetic field, a reliable switching between topologically distinct textures can be achieved at remanence« less

  4. Evolution of IPv6 Internet topology with unusual sudden changes

    NASA Astrophysics Data System (ADS)

    Ai, Jun; Zhao, Hai; Kathleen, M. Carley; Su, Zhan; Li, Hui

    2013-07-01

    The evolution of Internet topology is not always smooth but sometimes with unusual sudden changes. Consequently, identifying patterns of unusual topology evolution is critical for Internet topology modeling and simulation. We analyze IPv6 Internet topology evolution in IP-level graph to demonstrate how it changes in uncommon ways to restructure the Internet. After evaluating the changes of average degree, average path length, and some other metrics over time, we find that in the case of a large-scale growing the Internet becomes more robust; whereas in a top—bottom connection enhancement the Internet maintains its efficiency with links largely decreased.

  5. Focus-based filtering + clustering technique for power-law networks with small world phenomenon

    NASA Astrophysics Data System (ADS)

    Boutin, François; Thièvre, Jérôme; Hascoët, Mountaz

    2006-01-01

    Realistic interaction networks usually present two main properties: a power-law degree distribution and a small world behavior. Few nodes are linked to many nodes and adjacent nodes are likely to share common neighbors. Moreover, graph structure usually presents a dense core that is difficult to explore with classical filtering and clustering techniques. In this paper, we propose a new filtering technique accounting for a user-focus. This technique extracts a tree-like graph with also power-law degree distribution and small world behavior. Resulting structure is easily drawn with classical force-directed drawing algorithms. It is also quickly clustered and displayed into a multi-level silhouette tree (MuSi-Tree) from any user-focus. We built a new graph filtering + clustering + drawing API and report a case study.

  6. Small World.

    ERIC Educational Resources Information Center

    Jackson, Laura Christion

    1997-01-01

    Provides advice for small alumni offices on how to sponsor an alumni travel program, focusing on booking a travel agent, deciding where to go, using faculty as tour guides or lecturers, making time for alumni office staff to go along, remembering special touches, visiting local alumni, avoiding overt fund raising, and being prepared for problems.…

  7. Prediction of weak topological insulators in layered semiconductors.

    PubMed

    Yan, Binghai; Müchler, Lukas; Felser, Claudia

    2012-09-14

    We report the discovery of weak topological insulators by ab initio calculations in a honeycomb lattice. We propose a structure with an odd number of layers in the primitive unit cell as a prerequisite for forming weak topological insulators. Here, the single-layered KHgSb is the most suitable candidate for its large bulk energy gap of 0.24 eV. Its side surface hosts metallic surface states, forming two anisotropic Dirac cones. Although the stacking of even-layered structures leads to trivial insulators, the structures can host a quantum spin Hall layer with a large bulk gap, if an additional single layer exists as a stacking fault in the crystal. The reported honeycomb compounds can serve as prototypes to aid in the finding of new weak topological insulators in layered small-gap semiconductors.

  8. Topological transport in Dirac nodal-line semimetals

    NASA Astrophysics Data System (ADS)

    Rui, W. B.; Zhao, Y. X.; Schnyder, Andreas P.

    2018-04-01

    Topological nodal-line semimetals are characterized by one-dimensional Dirac nodal rings that are protected by the combined symmetry of inversion P and time-reversal T . The stability of these Dirac rings is guaranteed by a quantized ±π Berry phase and their low-energy physics is described by a one-parameter family of (2+1)-dimensional quantum field theories exhibiting the parity anomaly. Here we study the Berry-phase supported topological transport of P T -invariant nodal-line semimetals. We find that small inversion breaking allows for an electric-field-induced anomalous transverse current, whose universal component originates from the parity anomaly. Due to this Hall-like current, carriers at opposite sides of the Dirac nodal ring flow to opposite surfaces when an electric field is applied. To detect the topological currents, we propose a dumbbell device, which uses surface states to filter charges based on their momenta. Suggestions for experiments and device applications are discussed.

  9. Microscale vortex laser with controlled topological charge

    NASA Astrophysics Data System (ADS)

    Wang, Xing-Yuan; Chen, Hua-Zhou; Li, Ying; Li, Bo; Ma, Ren-Min

    2016-12-01

    A microscale vortex laser is a new type of coherent light source with small footprint that can directly generate vector vortex beams. However, a microscale laser with controlled topological charge, which is crucial for virtually any of its application, is still unrevealed. Here we present a microscale vortex laser with controlled topological charge. The vortex laser eigenmode was synthesized in a metamaterial engineered non-Hermitian micro-ring cavity system at exceptional point. We also show that the vortex laser cavity can operate at exceptional point stably to lase under optical pumping. The microscale vortex laser with controlled topological charge can serve as a unique and general building block for next-generation photonic integrated circuits and coherent vortex beam sources. The method we used here can be employed to generate lasing eigenmode with other complex functionalities. Project supported by the “Youth 1000 Talent Plan” Fund, Ministry of Education of China (Grant No. 201421) and the National Natural Science Foundation of China (Grant Nos. 11574012 and 61521004).

  10. Using multidimensional topological data analysis to identify traits of hip osteoarthritis.

    PubMed

    Rossi-deVries, Jasmine; Pedoia, Valentina; Samaan, Michael A; Ferguson, Adam R; Souza, Richard B; Majumdar, Sharmila

    2018-05-07

    Osteoarthritis (OA) is a multifaceted disease with many variables affecting diagnosis and progression. Topological data analysis (TDA) is a state-of-the-art big data analytics tool that can combine all variables into multidimensional space. TDA is used to simultaneously analyze imaging and gait analysis techniques. To identify biochemical and biomechanical biomarkers able to classify different disease progression phenotypes in subjects with and without radiographic signs of hip OA. Longitudinal study for comparison of progressive and nonprogressive subjects. In all, 102 subjects with and without radiographic signs of hip osteoarthritis. 3T, SPGR 3D MAPSS T 1ρ /T 2 , intermediate-weighted fat-suppressed fast spin-echo (FSE). Multidimensional data analysis including cartilage composition, bone shape, Kellgren-Lawrence (KL) classification of osteoarthritis, scoring hip osteoarthritis with MRI (SHOMRI), hip disability and osteoarthritis outcome score (HOOS). Analysis done using TDA, Kolmogorov-Smirnov (KS) testing, and Benjamini-Hochberg to rank P-value results to correct for multiple comparisons. Subjects in the later stages of the disease had an increased SHOMRI score (P < 0.0001), increased KL (P = 0.0012), and older age (P < 0.0001). Subjects in the healthier group showed intact cartilage and less pain. Subjects found between these two groups had a range of symptoms. Analysis of this subgroup identified knee biomechanics (P < 0.0001) as an initial marker of the disease that is noticeable before the morphological progression and degeneration. Further analysis of an OA subgroup with femoroacetabular impingement (FAI) showed anterior labral tears to be the most significant marker (P = 0.0017) between those FAI subjects with and without OA symptoms. The data-driven analysis obtained with TDA proposes new phenotypes of these subjects that partially overlap with the radiographic-based classical disease status classification and also shows the

  11. SMALL FISH MODELS FOR IDENTIFYING AND ASSESSING THE EFFECTS OF ENDOCRINE DISRUPTING CHEMICALS

    EPA Science Inventory

    Endocrine-disrupting chemicals (EDCs), in particular those which affect the hypothalamic-pituitary-gonadal (HPG) axis of vertebrates, have become a focus of regulatory screening and testing throughout the world. Small fish species, principally the fathead minnow (Pimephales prom...

  12. Topological magnetoelectric effects in microwave far-field radiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berezin, M.; Kamenetskii, E. O.; Shavit, R.

    2016-07-21

    Similar to electromagnetism, described by the Maxwell equations, the physics of magnetoelectric (ME) phenomena deals with the fundamental problem of the relationship between electric and magnetic fields. Despite a formal resemblance between the two notions, they concern effects of different natures. In general, ME-coupling effects manifest in numerous macroscopic phenomena in solids with space and time symmetry breakings. Recently, it was shown that the near fields in the proximity of a small ferrite particle with magnetic-dipolar-mode (MDM) oscillations have the space and time symmetry breakings and the topological properties of these fields are different from the topological properties of themore » free-space electromagnetic fields. Such MDM-originated fields—called magnetoelectric (ME) fields—carry both spin and orbital angular momenta. They are characterized by power-flow vortices and non-zero helicity. In this paper, we report on observation of the topological ME effects in far-field microwave radiation based on a small microwave antenna with a MDM ferrite resonator. We show that the microwave far-field radiation can be manifested with a torsion structure where an angle between the electric and magnetic field vectors varies. We discuss the question on observation of the regions of localized ME energy in far-field microwave radiation.« less

  13. Possible Origin of Efficient Navigation in Small Worlds

    NASA Astrophysics Data System (ADS)

    Hu, Yanqing; Wang, Yougui; Li, Daqing; Havlin, Shlomo; di, Zengru

    2011-03-01

    The small-world phenomenon is one of the most important properties found in social networks. It includes both short path lengths and efficient navigation between two individuals. It is found by Kleinberg that navigation is efficient only if the probability density distribution of an individual to have a friend at distance r scales as P(r)˜r-1. Although this spatial scaling is found in many empirical studies, the origin of how this scaling emerges is still missing. In this Letter, we propose the origin of this scaling law using the concept of entropy from statistical physics and show that this scaling is the result of optimization of collecting information in social networks.

  14. [Analysis of the Characteristics of Infantile Small World Neural Network Node Properties Correlated with the Influencing Factors].

    PubMed

    Qu, Haibo; Lu, Su; Zhang, Wenjing; Xiao, Yuan; Ning, Gang; Sun, Huaiqiang

    2016-10-01

    We applied resting-state functional magnetic resonance imaging(rfMRI)combined with graph theory to analyze 90 regions of the infantile small world neural network of the whole brain.We tried to get the following two points clear:1 whether the parameters of the node property of the infantile small world neural network are correlated with the level of infantile intelligence development;2 whether the parameters of the infantile small world neural network are correlated with the children’s baseline parameters,i.e.,the demographic parameters such as gender,age,parents’ education level,etc.Twelve cases of healthy infants were included in the investigation(9males and 3females with the average age of 33.42±8.42 months.)We then evaluated the level of infantile intelligence of all the cases and graded by Gesell Development Scale Test.We used a Siemens 3.0T Trio imaging system to perform resting-state(rs)EPI scans,and collected the BOLD functional Magnetic Resonance Imaging(fMRI)data.We performed the data processing with Statistical Parametric Mapping 5(SPM5)based on Matlab environment.Furthermore,we got the attributes of the whole brain small world and node attributes of 90 encephalic regions of templates of Anatomatic Automatic Labeling(ALL).At last,we carried out correlation study between the above-mentioned attitudes,intelligence scale parameters and demographic data.The results showed that many node attributes of small world neural network were closely correlated with intelligence scale parameters.Betweeness was mainly centered in thalamus,superior frontal gyrus,and occipital lobe(negative correlation).The r value of superior occipital gyrus associated with the individual and social intelligent scale was-0.729(P=0.007);degree was mainly centered in amygdaloid nucleus,superior frontal gyrus,and inferior parietal gyrus(positive correlation).The r value of inferior parietal gyrus associated with the gross motor intelligent scale was 0.725(P=0.008);efficiency was mainly

  15. Local communities obstruct global consensus: Naming game on multi-local-world networks

    NASA Astrophysics Data System (ADS)

    Lou, Yang; Chen, Guanrong; Fan, Zhengping; Xiang, Luna

    2018-02-01

    Community structure is essential for social communications, where individuals belonging to the same community are much more actively interacting and communicating with each other than those in different communities within the human society. Naming game, on the other hand, is a social communication model that simulates the process of learning a name of an object within a community of humans, where the individuals can generally reach global consensus asymptotically through iterative pair-wise conversations. The underlying network indicates the relationships among the individuals. In this paper, three typical topologies, namely random-graph, small-world and scale-free networks, are employed, which are embedded with the multi-local-world community structure, to study the naming game. Simulations show that (1) the convergence process to global consensus is getting slower as the community structure becomes more prominent, and eventually might fail; (2) if the inter-community connections are sufficiently dense, neither the number nor the size of the communities affects the convergence process; and (3) for different topologies with the same (or similar) average node-degree, local clustering of individuals obstruct or prohibit global consensus to take place. The results reveal the role of local communities in a global naming game in social network studies.

  16. Experimental Identification of Non-Abelian Topological Orders on a Quantum Simulator.

    PubMed

    Li, Keren; Wan, Yidun; Hung, Ling-Yan; Lan, Tian; Long, Guilu; Lu, Dawei; Zeng, Bei; Laflamme, Raymond

    2017-02-24

    Topological orders can be used as media for topological quantum computing-a promising quantum computation model due to its invulnerability against local errors. Conversely, a quantum simulator, often regarded as a quantum computing device for special purposes, also offers a way of characterizing topological orders. Here, we show how to identify distinct topological orders via measuring their modular S and T matrices. In particular, we employ a nuclear magnetic resonance quantum simulator to study the properties of three topologically ordered matter phases described by the string-net model with two string types, including the Z_{2} toric code, doubled semion, and doubled Fibonacci. The third one, non-Abelian Fibonacci order is notably expected to be the simplest candidate for universal topological quantum computing. Our experiment serves as the basic module, built on which one can simulate braiding of non-Abelian anyons and ultimately, topological quantum computation via the braiding, and thus provides a new approach of investigating topological orders using quantum computers.

  17. No Small World: Visions and Revisions of World Literature.

    ERIC Educational Resources Information Center

    Carroll, Michael Thomas, Ed.

    This collection of essays deals with world literature. The essays are focused on four primary goals: to map the conceptual and cultural problems inherent in common educational approaches to the subject which sometimes see world literature as a metanarrative of Western culture; to suggest new genres and perspectives; to consider specific curricular…

  18. Identifying high-risk small business industries for occupational safety and health interventions.

    PubMed

    Okun, A; Lentz, T J; Schulte, P; Stayner, L

    2001-03-01

    Approximately one-third (32%) of U.S. workers are employed in small business industries (those with 80% of workers in establishments with fewer than 100 employees), and approximately 53 million persons in private industry work in small business establishments. This study was performed to identify small business industries at high risk for occupational injuries, illnesses, and fatalities. Small business industries were identified from among all three- and four-digit Standard Industrial Classification (SIC) codes and ranked using Bureau of Labor Statistics (BLS) data by rates and numbers of occupational injuries, illnesses, and fatalities. Both incidence rates and number of injury, illness, and fatality cases were evaluated. The 253 small business industries identified accounted for 1,568 work-related fatalities (34% of all private industry). Transportation incidents and violent acts were the leading causes of these fatalities. Detailed injury and illness data were available for 105 small business industries, that accounted for 1,476,400 work-related injuries, and 55,850 occupational illnesses. Many of the small business industries had morbidity and mortality rates exceeding the average rates for all private industry. The highest risk small business industries, based on a combined morbidity and mortality index, included logging, cut stone and stone products, truck terminals, and roofing, siding, and sheet metal work. Identification of high-risk small business industries indicates priorities for those interested in developing targeted prevention programs.

  19. Strongly Correlated Topological Insulators

    DTIC Science & Technology

    2016-02-03

    Strongly Correlated Topological Insulators In the past year, the grant was used for work in the field of topological phases, with emphasis on finding...surface of topological insulators . In the past 3 years, we have started a new direction, that of fractional topological insulators . These are materials...Strongly Correlated Topological Insulators Report Title In the past year, the grant was used for work in the field of topological phases, with emphasis

  20. A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks.

    PubMed

    Gallos, Lazaros K; Makse, Hernán A; Sigman, Mariano

    2012-02-21

    The human brain is organized in functional modules. Such an organization presents a basic conundrum: Modules ought to be sufficiently independent to guarantee functional specialization and sufficiently connected to bind multiple processors for efficient information transfer. It is commonly accepted that small-world architecture of short paths and large local clustering may solve this problem. However, there is intrinsic tension between shortcuts generating small worlds and the persistence of modularity, a global property unrelated to local clustering. Here, we present a possible solution to this puzzle. We first show that a modified percolation theory can define a set of hierarchically organized modules made of strong links in functional brain networks. These modules are "large-world" self-similar structures and, therefore, are far from being small-world. However, incorporating weaker ties to the network converts it into a small world preserving an underlying backbone of well-defined modules. Remarkably, weak ties are precisely organized as predicted by theory maximizing information transfer with minimal wiring cost. This trade-off architecture is reminiscent of the "strength of weak ties" crucial concept of social networks. Such a design suggests a natural solution to the paradox of efficient information flow in the highly modular structure of the brain.

  1. Topological antiferromagnetic spintronics

    NASA Astrophysics Data System (ADS)

    Šmejkal, Libor; Mokrousov, Yuriy; Yan, Binghai; MacDonald, Allan H.

    2018-03-01

    The recent demonstrations of electrical manipulation and detection of antiferromagnetic spins have opened up a new chapter in the story of spintronics. Here, we review the emerging research field that is exploring the links between antiferromagnetic spintronics and topological structures in real and momentum space. Active topics include proposals to realize Majorana fermions in antiferromagnetic topological superconductors, to control topological protection and Dirac points by manipulating antiferromagnetic order parameters, and to exploit the anomalous and topological Hall effects of zero-net-moment antiferromagnets. We explain the basic concepts behind these proposals, and discuss potential applications of topological antiferromagnetic spintronics.

  2. Resonant UPS topologies for the emerging hybrid fiber-coaxial networks

    NASA Astrophysics Data System (ADS)

    Pinheiro, Humberto

    Uninterruptible power supply (UPS) systems have been extensively applied to feed critical loads in many areas. Typical examples of critical loads include life-support equipment, computers and telecommunication systems. Although all UPS systems have a common purpose to provide continuous power-to critical loads, the emerging hybrid fiber-coaxial networks have created the need for specific types of UPS topologies. For example, galvanic isolation for the load and the battery, small size, high input power factor, and trapezoidal output voltage waveforms are among the required features of UPS topologies for hybrid fiber-coaxial networks. None of the conventional UPS topologies meet all these requirements. Consequently. this thesis is directed towards the design and analysis of UPS topologies for this new application. Novel UPS topologies are proposed and control techniques are developed to allow operation at high switching frequencies without penalizing the converter efficiency. By the use of resonant converters in the proposed UPS topologies. a high input power factor is achieved without requiring a dedicated power factor correction stage. In addition, a self-sustained oscillation control method is proposed to ensure soft switching under all operating conditions. A detailed analytical treatment of the resonant converters in the proposed UPS topologies is presented and design procedures illustrated. Simulation and experimental results are presented to validate the analyses and to demonstrate the feasibility of the proposed schemes.

  3. Topological BF field theory description of topological insulators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cho, Gil Young; Moore, Joel E., E-mail: jemoore@berkeley.edu; Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720

    2011-06-15

    Research Highlights: > We show that a BF theory is the effective theory of 2D and 3D topological insulators. > The non-gauge-invariance of the bulk theory yields surface terms for a bosonized Dirac fermion. > The 'axion' term in electromagnetism is correctly obtained from gapped surfaces. > Generalizations to possible fractional phases are discussed in closing. - Abstract: Topological phases of matter are described universally by topological field theories in the same way that symmetry-breaking phases of matter are described by Landau-Ginzburg field theories. We propose that topological insulators in two and three dimensions are described by a version ofmore » abelian BF theory. For the two-dimensional topological insulator or quantum spin Hall state, this description is essentially equivalent to a pair of Chern-Simons theories, consistent with the realization of this phase as paired integer quantum Hall effect states. The BF description can be motivated from the local excitations produced when a {pi} flux is threaded through this state. For the three-dimensional topological insulator, the BF description is less obvious but quite versatile: it contains a gapless surface Dirac fermion when time-reversal-symmetry is preserved and yields 'axion electrodynamics', i.e., an electromagnetic E . B term, when time-reversal symmetry is broken and the surfaces are gapped. Just as changing the coefficients and charges of 2D Chern-Simons theory allows one to obtain fractional quantum Hall states starting from integer states, BF theory could also describe (at a macroscopic level) fractional 3D topological insulators with fractional statistics of point-like and line-like objects.« less

  4. Geometry of complex networks and topological centrality

    NASA Astrophysics Data System (ADS)

    Ranjan, Gyan; Zhang, Zhi-Li

    2013-09-01

    We explore the geometry of complex networks in terms of an n-dimensional Euclidean embedding represented by the Moore-Penrose pseudo-inverse of the graph Laplacian (L). The squared distance of a node i to the origin in this n-dimensional space (lii+), yields a topological centrality index, defined as C∗(i)=1/lii+. In turn, the sum of reciprocals of individual node centralities, ∑i1/C∗(i)=∑ilii+, or the trace of L, yields the well-known Kirchhoff index (K), an overall structural descriptor for the network. To put into context this geometric definition of centrality, we provide alternative interpretations of the proposed indices that connect them to meaningful topological characteristics - first, as forced detour overheads and frequency of recurrences in random walks that has an interesting analogy to voltage distributions in the equivalent electrical network; and then as the average connectedness of i in all the bi-partitions of the graph. These interpretations respectively help establish the topological centrality (C∗(i)) of node i as a measure of its overall position as well as its overall connectedness in the network; thus reflecting the robustness of i to random multiple edge failures. Through empirical evaluations using synthetic and real world networks, we demonstrate how the topological centrality is better able to distinguish nodes in terms of their structural roles in the network and, along with Kirchhoff index, is appropriately sensitive to perturbations/re-wirings in the network.

  5. Floquet topological phases with symmetry in all dimensions

    NASA Astrophysics Data System (ADS)

    Roy, Rahul; Harper, Fenner

    2017-05-01

    Dynamical systems may host a number of remarkable symmetry-protected phases that are qualitatively different from their static analogs. In this work, we consider the phase space of symmetry-respecting unitary evolutions in detail and identify several distinct classes of evolution that host dynamical order. Using ideas from group cohomology, we construct a set of interacting Floquet drives that generate dynamical symmetry-protected topological order for each nontrivial cohomology class in every dimension, illustrating our construction with explicit two-dimensional examples. We also identify a set of symmetry-protected Floquet drives that lie outside of the group cohomology construction, and a further class of symmetry-respecting topological drives which host chiral edge modes. We use these special drives to define a notion of phase (stable to a class of local perturbations in the bulk) and the concepts of relative and absolute topological order, which can be applied to many different classes of unitary evolutions. These include fully many-body localized unitary evolutions and time crystals.

  6. Control of water distribution networks with dynamic DMA topology using strictly feasible sequential convex programming

    NASA Astrophysics Data System (ADS)

    Wright, Robert; Abraham, Edo; Parpas, Panos; Stoianov, Ivan

    2015-12-01

    The operation of water distribution networks (WDN) with a dynamic topology is a recently pioneered approach for the advanced management of District Metered Areas (DMAs) that integrates novel developments in hydraulic modeling, monitoring, optimization, and control. A common practice for leakage management is the sectorization of WDNs into small zones, called DMAs, by permanently closing isolation valves. This facilitates water companies to identify bursts and estimate leakage levels by measuring the inlet flow for each DMA. However, by permanently closing valves, a number of problems have been created including reduced resilience to failure and suboptimal pressure management. By introducing a dynamic topology to these zones, these disadvantages can be eliminated while still retaining the DMA structure for leakage monitoring. In this paper, a novel optimization method based on sequential convex programming (SCP) is outlined for the control of a dynamic topology with the objective of reducing average zone pressure (AZP). A key attribute for control optimization is reliable convergence. To achieve this, the SCP method we propose guarantees that each optimization step is strictly feasible, resulting in improved convergence properties. By using a null space algorithm for hydraulic analyses, the computations required are also significantly reduced. The optimized control is actuated on a real WDN operated with a dynamic topology. This unique experimental program incorporates a number of technologies set up with the objective of investigating pioneering developments in WDN management. Preliminary results indicate AZP reductions for a dynamic topology of up to 6.5% over optimally controlled fixed topology DMAs. This article was corrected on 12 JAN 2016. See the end of the full text for details.

  7. Topological crystalline materials: General formulation, module structure, and wallpaper groups

    NASA Astrophysics Data System (ADS)

    Shiozaki, Ken; Sato, Masatoshi; Gomi, Kiyonori

    2017-06-01

    We formulate topological crystalline materials on the basis of the twisted equivariant K theory. Basic ideas of the twisted equivariant K theory are explained with application to topological phases protected by crystalline symmetries in mind, and systematic methods of topological classification for crystalline materials are presented. Our formulation is applicable to bulk gapful topological crystalline insulators/superconductors and their gapless boundary and defect states, as well as bulk gapless topological materials such as Weyl and Dirac semimetals, and nodal superconductors. As an application of our formulation, we present a complete classification of topological crystalline surface states, in the absence of time-reversal invariance. The classification works for gapless surface states of three-dimensional insulators, as well as full gapped two-dimensional insulators. Such surface states and two-dimensional insulators are classified in a unified way by 17 wallpaper groups, together with the presence or the absence of (sublattice) chiral symmetry. We identify the topological numbers and their representations under the wallpaper group operation. We also exemplify the usefulness of our formulation in the classification of bulk gapless phases. We present a class of Weyl semimetals and Weyl superconductors that are topologically protected by inversion symmetry.

  8. Topological Aspects of Information Retrieval.

    ERIC Educational Resources Information Center

    Egghe, Leo; Rousseau, Ronald

    1998-01-01

    Discusses topological aspects of theoretical information retrieval, including retrieval topology; similarity topology; pseudo-metric topology; document spaces as topological spaces; Boolean information retrieval as a subsystem of any topological system; and proofs of theorems. (LRW)

  9. Topological charge and cooling scales in pure SU(2) lattice gauge theory

    NASA Astrophysics Data System (ADS)

    Berg, Bernd A.; Clarke, David A.

    2018-03-01

    Using Monte Carlo simulations with overrelaxation, we have equilibrated lattices up to β =2.928 , size 6 04, for pure SU(2) lattice gauge theory with the Wilson action. We calculate topological charges with the standard cooling method and find that they become more reliable with increasing β values and lattice sizes. Continuum limit estimates of the topological susceptibility χ are obtained of which we favor χ1 /4/Tc=0.643 (12 ) , where Tc is the SU(2) deconfinement temperature. Differences between cooling length scales in different topological sectors turn out to be too small to be detectable within our statistical errors.

  10. Topological entanglement entropy with a twist.

    PubMed

    Brown, Benjamin J; Bartlett, Stephen D; Doherty, Andrew C; Barrett, Sean D

    2013-11-27

    Defects in topologically ordered models have interesting properties that are reminiscent of the anyonic excitations of the models themselves. For example, dislocations in the toric code model are known as twists and possess properties that are analogous to Ising anyons. We strengthen this analogy by using the topological entanglement entropy as a diagnostic tool to identify properties of both defects and excitations in the toric code. Specifically, we show, through explicit calculation, that the toric code model including twists and dyon excitations has the same quantum dimensions, the same total quantum dimension, and the same fusion rules as an Ising anyon model.

  11. The topology of large-scale structure. VI - Slices of the universe

    NASA Astrophysics Data System (ADS)

    Park, Changbom; Gott, J. R., III; Melott, Adrian L.; Karachentsev, I. D.

    1992-03-01

    Results of an investigation of the topology of large-scale structure in two observed slices of the universe are presented. Both slices pass through the Coma cluster and their depths are 100 and 230/h Mpc. The present topology study shows that the largest void in the CfA slice is divided into two smaller voids by a statistically significant line of galaxies. The topology of toy models like the white noise and bubble models is shown to be inconsistent with that of the observed slices. A large N-body simulation was made of the biased cloud dark matter model and the slices are simulated by matching them in selection functions and boundary conditions. The genus curves for these simulated slices are spongelike and have a small shift in the direction of a meatball topology like those of observed slices.

  12. The topology of large-scale structure. VI - Slices of the universe

    NASA Technical Reports Server (NTRS)

    Park, Changbom; Gott, J. R., III; Melott, Adrian L.; Karachentsev, I. D.

    1992-01-01

    Results of an investigation of the topology of large-scale structure in two observed slices of the universe are presented. Both slices pass through the Coma cluster and their depths are 100 and 230/h Mpc. The present topology study shows that the largest void in the CfA slice is divided into two smaller voids by a statistically significant line of galaxies. The topology of toy models like the white noise and bubble models is shown to be inconsistent with that of the observed slices. A large N-body simulation was made of the biased cloud dark matter model and the slices are simulated by matching them in selection functions and boundary conditions. The genus curves for these simulated slices are spongelike and have a small shift in the direction of a meatball topology like those of observed slices.

  13. Sparsely-synchronized brain rhythm in a small-world neural network

    NASA Astrophysics Data System (ADS)

    Kim, Sang-Yoon; Lim, Woochang

    2013-07-01

    Sparsely-synchronized cortical rhythms, associated with diverse cognitive functions, have been observed in electric recordings of brain activity. At the population level, cortical rhythms exhibit small-amplitude fast oscillations while at the cellular level, individual neurons show stochastic firings sparsely at a much lower rate than the population rate. We study the effect of network architecture on sparse synchronization in an inhibitory population of subthreshold Morris-Lecar neurons (which cannot fire spontaneously without noise). Previously, sparse synchronization was found to occur for cases of both global coupling ( i.e., regular all-to-all coupling) and random coupling. However, a real neural network is known to be non-regular and non-random. Here, we consider sparse Watts-Strogatz small-world networks which interpolate between a regular lattice and a random graph via rewiring. We start from a regular lattice with only short-range connections and then investigate the emergence of sparse synchronization by increasing the rewiring probability p for the short-range connections. For p = 0, the average synaptic path length between pairs of neurons becomes long; hence, only an unsynchronized population state exists because the global efficiency of information transfer is low. However, as p is increased, long-range connections begin to appear, and global effective communication between distant neurons may be available via shorter synaptic paths. Consequently, as p passes a threshold p th (}~ 0.044), sparsely-synchronized population rhythms emerge. However, with increasing p, longer axon wirings become expensive because of their material and energy costs. At an optimal value p* DE (}~ 0.24) of the rewiring probability, the ratio of the synchrony degree to the wiring cost is found to become maximal. In this way, an optimal sparse synchronization is found to occur at a minimal wiring cost in an economic small-world network through trade-off between synchrony and

  14. Quantum algorithms for topological and geometric analysis of data

    PubMed Central

    Lloyd, Seth; Garnerone, Silvano; Zanardi, Paolo

    2016-01-01

    Extracting useful information from large data sets can be a daunting task. Topological methods for analysing data sets provide a powerful technique for extracting such information. Persistent homology is a sophisticated tool for identifying topological features and for determining how such features persist as the data is viewed at different scales. Here we present quantum machine learning algorithms for calculating Betti numbers—the numbers of connected components, holes and voids—in persistent homology, and for finding eigenvectors and eigenvalues of the combinatorial Laplacian. The algorithms provide an exponential speed-up over the best currently known classical algorithms for topological data analysis. PMID:26806491

  15. Topological mirror superconductivity.

    PubMed

    Zhang, Fan; Kane, C L; Mele, E J

    2013-08-02

    We demonstrate the existence of topological superconductors (SCs) protected by mirror and time-reversal symmetries. D-dimensional (D=1, 2, 3) crystalline SCs are characterized by 2(D-1) independent integer topological invariants, which take the form of mirror Berry phases. These invariants determine the distribution of Majorana modes on a mirror symmetric boundary. The parity of total mirror Berry phase is the Z(2) index of a class DIII SC, implying that a DIII topological SC with a mirror line must also be a topological mirror SC but not vice versa and that a DIII SC with a mirror plane is always time-reversal trivial but can be mirror topological. We introduce representative models and suggest experimental signatures in feasible systems. Advances in quantum computing, the case for nodal SCs, the case for class D, and topological SCs protected by rotational symmetries are pointed out.

  16. Topological Insulators: A New Platform for Fundamental Science and Applications

    NASA Astrophysics Data System (ADS)

    Bansil, Arun

    2013-03-01

    Topological insulators constitute a new phase of quantum matter whose recent discovery has focused world-wide attention on wide-ranging phenomena in materials driven by spin-orbit coupling effects well beyond their traditional role in determining magnetic properties. I will discuss how by exploiting electronic structure techniques we have been able to predict and understand the characteristics of many new classes of binary, ternary and quaternary topologically interesting systems. The flexibility of chemical, structural and magnetic parameters so obtained is the key ingredient for exploring fundamental science questions, including novel spin-textures and exotic superconducting states, as well as for the realization of multi-functional topological devices for thermoelectric, spintronics, information processing and other applications. I will also highlight new insights that have been enabled through our material-specific modeling of angle-resolved photoemission (ARPES) and scanning tunneling (STS) spectroscopies of topological surface states, including effects of the photoemission and tunneling matrix element, which is well-known to be important for a robust interpretation of various highly resolved spectroscopies. Work supported by the Materials Science & Engineering Division, Basic Energy Sciences, U. S. D. O. E.

  17. Seroprevalence and characterization of pestivirus infections in small ruminants and new world camelids in Switzerland.

    PubMed

    Danuser, R; Vogt, H-R; Kaufmann, Th; Peterhans, E; Zanoni, R

    2009-03-01

    The seroprevalence of pestivirus infections in small ruminants and new world camelids in Switzerland was determined. In 5'059 sera of sheep from 382 herds, 503 sera of goats from 54 herds and 109 sera of alpacas and lamas from 53 herds, population prevalences of 16.1% (sheep), 25.4% (goats) and 4.6% (new world camelids), respectively, were found. In order to determine the source of infection, the serological reactions were further characterized by cross-neutralization against two pestiviruses representing the genotypes BVDV (Bovine Virus Diarrhea Virus)-1 and BDV (Border Disease Virus)-1. Based on the ratio of respective antibody titres, 56.1% of the infections in sheep were induced by a BDV-1, 12.9% by a BVDV-1 and 31.0% by an unresolved pestivirus. In goats, the corresponding proportions were 23.4%, 10.2% and 66.4%, respectively. In Alpacas and Lamas, the source of infection of 1 animal was BDV-1 and that of 4 seropositive animals remained unresolved. In view of the phylogenetic relationship between pestiviruses, the unresolved source of infection is most probably attributable to other pestivirus genotypes circulating in small ruminants and new world camelids. Due to the predominance of pestiviral genotypes other than BVDV-1, the risk of transmission of BVDV from persistently infected small ruminants and new world camelids to cattle appears to be moderate, apart from close direct contact in mixed animal husbandry, communal pasturing and grazing in the Alps.

  18. Accessing the topological susceptibility via the Gribov horizon

    NASA Astrophysics Data System (ADS)

    Dudal, D.; Felix, C. P.; Guimaraes, M. S.; Sorella, S. P.

    2017-10-01

    The topological susceptibility, χ4 , following the work of Witten and Veneziano, plays a key role in identifying the relative magnitude of the η' mass, the so-called U (1 )A problem. A nonzero χ4 is caused by the Veneziano ghost, the occurrence of an unphysical massless pole in the correlation function of the topological current Kμ. In this paper, we investigate the topological susceptibility, χ4, in S U (3 ) and S U (2 ) Euclidean Yang-Mills theory using an appropriate Padé approximation tool and a nonperturbative gluon propagator, within a Becchi-Rouet-Stora-Tyutin invariant framework and by taking into account Gribov copies in a general linear covariant gauge.

  19. Disorder-induced transitions in resonantly driven Floquet topological insulators

    NASA Astrophysics Data System (ADS)

    Titum, Paraj; Lindner, Netanel H.; Refael, Gil

    2017-08-01

    We investigate the effects of disorder in Floquet topological insulators (FTIs) occurring in semiconductor quantum wells. Such FTIs are induced by resonantly driving a transition between the valence and conduction bands. We show that when disorder is added, the topological nature of such FTIs persists as long as there is a mobility gap at the resonant quasienergy. For strong enough disorder, this gap closes and all the states become localized as the system undergoes a transition to a trivial insulator. Interestingly, the effects of disorder are not necessarily adverse: we show that in the same quantum well, disorder can also induce a transition from a trivial to a topological system, thereby establishing a Floquet topological Anderson insulator (FTAI). We identify the conditions on the driving field necessary for observing such a transition.

  20. Synaptic Impairment and Robustness of Excitatory Neuronal Networks with Different Topologies

    PubMed Central

    Mirzakhalili, Ehsan; Gourgou, Eleni; Booth, Victoria; Epureanu, Bogdan

    2017-01-01

    Synaptic deficiencies are a known hallmark of neurodegenerative diseases, but the diagnosis of impaired synapses on the cellular level is not an easy task. Nonetheless, changes in the system-level dynamics of neuronal networks with damaged synapses can be detected using techniques that do not require high spatial resolution. This paper investigates how the structure/topology of neuronal networks influences their dynamics when they suffer from synaptic loss. We study different neuronal network structures/topologies by specifying their degree distributions. The modes of the degree distribution can be used to construct networks that consist of rich clubs and resemble small world networks, as well. We define two dynamical metrics to compare the activity of networks with different structures: persistent activity (namely, the self-sustained activity of the network upon removal of the initial stimulus) and quality of activity (namely, percentage of neurons that participate in the persistent activity of the network). Our results show that synaptic loss affects the persistent activity of networks with bimodal degree distributions less than it affects random networks. The robustness of neuronal networks enhances when the distance between the modes of the degree distribution increases, suggesting that the rich clubs of networks with distinct modes keep the whole network active. In addition, a tradeoff is observed between the quality of activity and the persistent activity. For a range of distributions, both of these dynamical metrics are considerably high for networks with bimodal degree distribution compared to random networks. We also propose three different scenarios of synaptic impairment, which may correspond to different pathological or biological conditions. Regardless of the network structure/topology, results demonstrate that synaptic loss has more severe effects on the activity of the network when impairments are correlated with the activity of the neurons. PMID

  1. Nexus fermions in topological symmorphic crystalline metals

    DOE PAGES

    Chang, Guoqing; Xu, Su-Yang; Huang, Shin-Ming; ...

    2017-05-10

    Topological metals and semimetals (TMs) have recently drawn significant interest. These materials give rise to condensed matter realizations of many important concepts in high-energy physics, leading to wide-ranging protected properties in transport and spectroscopic experiments. It has been well-established that the known TMs can be classified by the dimensionality of the topologically protected band degeneracies. While Weyl and Dirac semimetals feature zero-dimensional points, the band crossing of nodal-line semimetals forms a one-dimensional closed loop. In this paper, we identify a TM that goes beyond the above paradigms. It shows an exotic configuration of degeneracies without a well-defined dimensionality. Specifically, itmore » consists of 0D nexus with triple-degeneracy that interconnects 1D lines with double-degeneracy. We show that, because of the novel form of band crossing, the new TM cannot be described by the established results that characterize the topology of the Dirac and Weyl nodes. Moreover, triply-degenerate nodes realize emergent fermionic quasiparticles not present in relativistic quantum field theory. We present materials candidates. Thus, our results open the door for realizing new topological phenomena and fermions including transport anomalies and spectroscopic responses in metallic crystals with nontrivial topology beyond the Weyl/Dirac paradigm.« less

  2. Avoiding the "It's a Small World" Effect: A Lesson Plan to Explore Diversity

    ERIC Educational Resources Information Center

    Endacott, Jason L.; Bowles, Freddie A.

    2013-01-01

    Classroom instruction about other cultures all too often resembles the Disney version of "It's a Small World" with Fantasyland-like cultural stereotypes, ceremonial activities, and traditional dress that can lead to serious misunderstandings about the depth and complexity of global societies. Social studies instruction presents the…

  3. Z3 topological order in the face-centered-cubic quantum plaquette model

    NASA Astrophysics Data System (ADS)

    Devakul, Trithep

    2018-04-01

    We examine the topological order in the resonating singlet valence plaquette (RSVP) phase of the hard-core quantum plaquette model (QPM) on the face centered cubic (FCC) lattice. To do this, we construct a Rohksar-Kivelson type Hamiltonian of local plaquette resonances. This model is shown to exhibit a Z3 topological order, which we show by identifying a Z3 topological constant (which leads to a 33-fold topological ground state degeneracy on the 3-torus) and topological pointlike charge and looplike magnetic excitations which obey Z3 statistics. We also consider an exactly solvable generalization of this model, which makes the geometrical origin of the Z3 order explicitly clear. For other models and lattices, such generalizations produce a wide variety of topological phases, some of which are novel fracton phases.

  4. Topology Analysis of Social Networks Extracted from Literature

    PubMed Central

    2015-01-01

    In a world where complex networks are an increasingly important part of science, it is interesting to question how the new reading of social realities they provide applies to our cultural background and in particular, popular culture. Are authors of successful novels able to reproduce social networks faithful to the ones found in reality? Is there any common trend connecting an author’s oeuvre, or a genre of fiction? Such an analysis could provide new insight on how we, as a culture, perceive human interactions and consume media. The purpose of the work presented in this paper is to define the signature of a novel’s story based on the topological analysis of its social network of characters. For this purpose, an automated tool was built that analyses the dialogs in novels, identifies characters and computes their relationships in a time-dependent manner in order to assess the network’s evolution over the course of the story. PMID:26039072

  5. A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks

    PubMed Central

    Gallos, Lazaros K.; Makse, Hernán A.; Sigman, Mariano

    2012-01-01

    The human brain is organized in functional modules. Such an organization presents a basic conundrum: Modules ought to be sufficiently independent to guarantee functional specialization and sufficiently connected to bind multiple processors for efficient information transfer. It is commonly accepted that small-world architecture of short paths and large local clustering may solve this problem. However, there is intrinsic tension between shortcuts generating small worlds and the persistence of modularity, a global property unrelated to local clustering. Here, we present a possible solution to this puzzle. We first show that a modified percolation theory can define a set of hierarchically organized modules made of strong links in functional brain networks. These modules are “large-world” self-similar structures and, therefore, are far from being small-world. However, incorporating weaker ties to the network converts it into a small world preserving an underlying backbone of well-defined modules. Remarkably, weak ties are precisely organized as predicted by theory maximizing information transfer with minimal wiring cost. This trade-off architecture is reminiscent of the “strength of weak ties” crucial concept of social networks. Such a design suggests a natural solution to the paradox of efficient information flow in the highly modular structure of the brain. PMID:22308319

  6. Topological superconductors: a review.

    PubMed

    Sato, Masatoshi; Ando, Yoichi

    2017-07-01

    This review elaborates pedagogically on the fundamental concept, basic theory, expected properties, and materials realizations of topological superconductors. The relation between topological superconductivity and Majorana fermions are explained, and the difference between dispersive Majorana fermions and a localized Majorana zero mode is emphasized. A variety of routes to topological superconductivity are explained with an emphasis on the roles of spin-orbit coupling. Present experimental situations and possible signatures of topological superconductivity are summarized with an emphasis on intrinsic topological superconductors.

  7. Topological superconductors: a review

    NASA Astrophysics Data System (ADS)

    Sato, Masatoshi; Ando, Yoichi

    2017-07-01

    This review elaborates pedagogically on the fundamental concept, basic theory, expected properties, and materials realizations of topological superconductors. The relation between topological superconductivity and Majorana fermions are explained, and the difference between dispersive Majorana fermions and a localized Majorana zero mode is emphasized. A variety of routes to topological superconductivity are explained with an emphasis on the roles of spin-orbit coupling. Present experimental situations and possible signatures of topological superconductivity are summarized with an emphasis on intrinsic topological superconductors.

  8. Topological Nodal-Net Semimetal in a Graphene Network Structure

    NASA Astrophysics Data System (ADS)

    Wang, Jian-Tao; Nie, Simin; Weng, Hongming; Kawazoe, Yoshiyuki; Chen, Changfeng

    2018-01-01

    Topological semimetals are characterized by the nodal points in their electronic structure near the Fermi level, either discrete or forming a continuous line or ring, which are responsible for exotic properties related to the topology of bulk bands. Here we identify by ab initio calculations a distinct topological semimetal that exhibits nodal nets comprising multiple interconnected nodal lines in bulk and have two coupled drumheadlike flat bands around the Fermi level on its surface. This nodal net semimetal state is proposed to be realized in a graphene network structure that can be constructed by inserting a benzene ring into each C- C bond in the bct-C4 lattice or by a crystalline modification of the (5,5) carbon nanotube. These results expand the realm of nodal manifolds in topological semimetals, offering a new platform for exploring novel physics in these fascinating materials.

  9. Topological magnetoplasmon

    PubMed Central

    Jin, Dafei; Lu, Ling; Wang, Zhong; Fang, Chen; Joannopoulos, John D.; Soljačić, Marin; Fu, Liang; Fang, Nicholas X.

    2016-01-01

    Classical wave fields are real-valued, ensuring the wave states at opposite frequencies and momenta to be inherently identical. Such a particle–hole symmetry can open up new possibilities for topological phenomena in classical systems. Here we show that the historically studied two-dimensional (2D) magnetoplasmon, which bears gapped bulk states and gapless one-way edge states near-zero frequency, is topologically analogous to the 2D topological p+ip superconductor with chiral Majorana edge states and zero modes. We further predict a new type of one-way edge magnetoplasmon at the interface of opposite magnetic domains, and demonstrate the existence of zero-frequency modes bounded at the peripheries of a hollow disk. These findings can be readily verified in experiment, and can greatly enrich the topological phases in bosonic and classical systems. PMID:27892453

  10. Topological magnetoplasmon

    DOE PAGES

    Jin, Dafei; Lu, Ling; Wang, Zhong; ...

    2016-11-28

    Classical wave fields are real-valued, ensuring the wave states at opposite frequencies and momenta to be inherently identical. Such a particle–hole symmetry can open up new possibilities for topological phenomena in classical systems. Here we show that the historically studied two-dimensional (2D) magnetoplasmon, which bears gapped bulk states and gapless one-way edge states near-zero frequency, is topologically analogous to the 2D topological p+ip superconductor with chiral Majorana edge states and zero modes. We further predict a new type of one-way edge magnetoplasmon at the interface of opposite magnetic domains, and demonstrate the existence of zero-frequency modes bounded at the peripheriesmore » of a hollow disk. Finally, these findings can be readily verified in experiment, and can greatly enrich the topological phases in bosonic and classical systems.« less

  11. Topological Materials: Weyl Semimetals

    NASA Astrophysics Data System (ADS)

    Yan, Binghai; Felser, Claudia

    2017-03-01

    Topological insulators and topological semimetals are both new classes of quantum materials, which are characterized by surface states induced by the topology of the bulk band structure. Topological Dirac or Weyl semimetals show linear dispersion around nodes, termed the Dirac or Weyl points, as the three-dimensional analog of graphene. We review the basic concepts and compare these topological states of matter from the materials perspective with a special focus on Weyl semimetals. The TaAs family is the ideal materials class to introduce the signatures of Weyl points in a pedagogical way, from Fermi arcs to the chiral magnetotransport properties, followed by hunting for the type-II Weyl semimetals in WTe2, MoTe2, and related compounds. Many materials are members of big families, and topological properties can be tuned. As one example, we introduce the multifunctional topological materials, Heusler compounds, in which both topological insulators and magnetic Weyl semimetals can be found. Instead of a comprehensive review, this article is expected to serve as a helpful introduction and summary by taking a snapshot of the quickly expanding field.

  12. Topological invariant and cotranslational symmetry in strongly interacting multi-magnon systems

    NASA Astrophysics Data System (ADS)

    Qin, Xizhou; Mei, Feng; Ke, Yongguan; Zhang, Li; Lee, Chaohong

    2018-01-01

    It is still an outstanding challenge to characterize and understand the topological features of strongly interacting states such as bound states in interacting quantum systems. Here, by introducing a cotranslational symmetry in an interacting multi-particle quantum system, we systematically develop a method to define a Chern invariant, which is a generalization of the well-known Thouless-Kohmoto-Nightingale-den Nijs invariant, for identifying strongly interacting topological states. As an example, we study the topological multi-magnon states in a generalized Heisenberg XXZ model, which can be realized by the currently available experiment techniques of cold atoms (Aidelsburger et al 2013 Phys. Rev. Lett. 111, 185301; Miyake et al 2013 Phys. Rev. Lett. 111, 185302). Through calculating the two-magnon excitation spectrum and the defined Chern number, we explore the emergence of topological edge bound states and give their topological phase diagram. We also analytically derive an effective single-particle Hofstadter superlattice model for a better understanding of the topological bound states. Our results not only provide a new approach to defining a topological invariant for interacting multi-particle systems, but also give insights into the characterization and understanding of strongly interacting topological states.

  13. The effect of the neural activity on topological properties of growing neural networks.

    PubMed

    Gafarov, F M; Gafarova, V R

    2016-09-01

    The connectivity structure in cortical networks defines how information is transmitted and processed, and it is a source of the complex spatiotemporal patterns of network's development, and the process of creation and deletion of connections is continuous in the whole life of the organism. In this paper, we study how neural activity influences the growth process in neural networks. By using a two-dimensional activity-dependent growth model we demonstrated the neural network growth process from disconnected neurons to fully connected networks. For making quantitative investigation of the network's activity influence on its topological properties we compared it with the random growth network not depending on network's activity. By using the random graphs theory methods for the analysis of the network's connections structure it is shown that the growth in neural networks results in the formation of a well-known "small-world" network.

  14. A community detection algorithm using network topologies and rule-based hierarchical arc-merging strategies

    PubMed Central

    2017-01-01

    The authors use four criteria to examine a novel community detection algorithm: (a) effectiveness in terms of producing high values of normalized mutual information (NMI) and modularity, using well-known social networks for testing; (b) examination, meaning the ability to examine mitigating resolution limit problems using NMI values and synthetic networks; (c) correctness, meaning the ability to identify useful community structure results in terms of NMI values and Lancichinetti-Fortunato-Radicchi (LFR) benchmark networks; and (d) scalability, or the ability to produce comparable modularity values with fast execution times when working with large-scale real-world networks. In addition to describing a simple hierarchical arc-merging (HAM) algorithm that uses network topology information, we introduce rule-based arc-merging strategies for identifying community structures. Five well-studied social network datasets and eight sets of LFR benchmark networks were employed to validate the correctness of a ground-truth community, eight large-scale real-world complex networks were used to measure its efficiency, and two synthetic networks were used to determine its susceptibility to two resolution limit problems. Our experimental results indicate that the proposed HAM algorithm exhibited satisfactory performance efficiency, and that HAM-identified and ground-truth communities were comparable in terms of social and LFR benchmark networks, while mitigating resolution limit problems. PMID:29121100

  15. Brain anatomical networks in early human brain development.

    PubMed

    Fan, Yong; Shi, Feng; Smith, Jeffrey Keith; Lin, Weili; Gilmore, John H; Shen, Dinggang

    2011-02-01

    Recent neuroimaging studies have demonstrated that human brain networks have economic small-world topology and modular organization, enabling efficient information transfer among brain regions. However, it remains largely unknown how the small-world topology and modular organization of human brain networks emerge and develop. Using longitudinal MRI data of 28 healthy pediatric subjects, collected at their ages of 1 month, 1 year, and 2 years, we analyzed development patterns of brain anatomical networks derived from morphological correlations of brain regional volumes. The results show that the brain network of 1-month-olds has the characteristically economic small-world topology and nonrandom modular organization. The network's cost efficiency increases with the brain development to 1 year and 2 years, so does the modularity, providing supportive evidence for the hypothesis that the small-world topology and the modular organization of brain networks are established during early brain development to support rapid synchronization and information transfer with minimal rewiring cost, as well as to balance between local processing and global integration of information. Copyright © 2010. Published by Elsevier Inc.

  16. Topological Acoustics

    NASA Astrophysics Data System (ADS)

    Yang, Zhaoju; Gao, Fei; Shi, Xihang; Lin, Xiao; Gao, Zhen; Chong, Yidong; Zhang, Baile

    2015-03-01

    The manipulation of acoustic wave propagation in fluids has numerous applications, including some in everyday life. Acoustic technologies frequently develop in tandem with optics, using shared concepts such as waveguiding and metamedia. It is thus noteworthy that an entirely novel class of electromagnetic waves, known as "topological edge states," has recently been demonstrated. These are inspired by the electronic edge states occurring in topological insulators, and possess a striking and technologically promising property: the ability to travel in a single direction along a surface without backscattering, regardless of the existence of defects or disorder. Here, we develop an analogous theory of topological fluid acoustics, and propose a scheme for realizing topological edge states in an acoustic structure containing circulating fluids. The phenomenon of disorder-free one-way sound propagation, which does not occur in ordinary acoustic devices, may have novel applications for acoustic isolators, modulators, and transducers.

  17. A quantized microwave quadrupole insulator with topologically protected corner states

    NASA Astrophysics Data System (ADS)

    Peterson, Christopher W.; Benalcazar, Wladimir A.; Hughes, Taylor L.; Bahl, Gaurav

    2018-03-01

    The theory of electric polarization in crystals defines the dipole moment of an insulator in terms of a Berry phase (geometric phase) associated with its electronic ground state. This concept not only solves the long-standing puzzle of how to calculate dipole moments in crystals, but also explains topological band structures in insulators and superconductors, including the quantum anomalous Hall insulator and the quantum spin Hall insulator, as well as quantized adiabatic pumping processes. A recent theoretical study has extended the Berry phase framework to also account for higher electric multipole moments, revealing the existence of higher-order topological phases that have not previously been observed. Here we demonstrate experimentally a member of this predicted class of materials—a quantized quadrupole topological insulator—produced using a gigahertz-frequency reconfigurable microwave circuit. We confirm the non-trivial topological phase using spectroscopic measurements and by identifying corner states that result from the bulk topology. In addition, we test the critical prediction that these corner states are protected by the topology of the bulk, and are not due to surface artefacts, by deforming the edges of the crystal lattice from the topological to the trivial regime. Our results provide conclusive evidence of a unique form of robustness against disorder and deformation, which is characteristic of higher-order topological insulators.

  18. Harmonic stochastic resonance-enhanced signal detecting in NW small-world neural network

    NASA Astrophysics Data System (ADS)

    Wang, Dao-Guang; Liang, Xiao-Ming; Wang, Jing; Yang, Cheng-Fang; Liu, Kai; Lü, Hua-Ping

    2010-11-01

    The harmonic stochastic resonance-enhanced signal detecting in Newman-Watts small-world neural network is studied using the Hodgkin-Huxley dynamical equation with noise. If the connection probability p, coupling strength gsyn and noise intensity D matches well, higher order resonance will be found and an optimal signal-to-noise ratio will be obtained. Then, the reasons are given to explain the mechanism of this appearance.

  19. Topological Classification of Crystalline Insulators through Band Structure Combinatorics

    NASA Astrophysics Data System (ADS)

    Kruthoff, Jorrit; de Boer, Jan; van Wezel, Jasper; Kane, Charles L.; Slager, Robert-Jan

    2017-10-01

    We present a method for efficiently enumerating all allowed, topologically distinct, electronic band structures within a given crystal structure in all physically relevant dimensions. The algorithm applies to crystals without time-reversal, particle-hole, chiral, or any other anticommuting or anti-unitary symmetries. The results presented match the mathematical structure underlying the topological classification of these crystals in terms of K -theory and therefore elucidate this abstract mathematical framework from a simple combinatorial perspective. Using a straightforward counting procedure, we classify all allowed topological phases of spinless particles in crystals in class A . Employing this classification, we study transitions between topological phases within class A that are driven by band inversions at high-symmetry points in the first Brillouin zone. This enables us to list all possible types of phase transitions within a given crystal structure and to identify whether or not they give rise to intermediate Weyl semimetallic phases.

  20. Cosmic Topology: Studying The Shape And Size Of Our Universe

    NASA Astrophysics Data System (ADS)

    Yzaguirre, Amelia; Hajian, A.

    2010-01-01

    The question of the size and the shape of our universe is a very old problem that has received considerable attention over the past few years. The simplest cosmological model predicts that the mean density of the universe is very close to the critical density, admitting a local geometry of the universe that is flat. Current results from different cosmological observations confirm this to the percent level accuracy. General Relativity (being a local theory) only determines local geometry, which allows for the possibility of a multiply connected universe with a zero (or small) curvature. To study the global shape, or topology, of the universe, one can use cosmological observations on large scales. In this project we investigate the possibility of a ``small universe'', that is, a compact finite space, by searching for planar symmetries in the CMB anisotropy maps provided by the five-year WMAP observations in two foreground cleaned maps (WMAP ILC map and the Tegmark, et al. (TOH) map ). Our results strongly suggest that the small universe model is not a viable topology for the universe.

  1. Small Worlds Week: An online celebration of planetary science using social media to reach millions

    NASA Astrophysics Data System (ADS)

    Mayo, Louis

    2015-11-01

    In celebration of the many recent discoveries from New Horizons, Dawn, Rosetta, and Cassini, NASA launched Small Worlds Week, an online, social media driven outreach program leveraging the infrastructure of Sun-Earth Days that included a robust web design, exemplary education materials, hands-on fun activities, multimedia resources, science and career highlights, and a culminating social media event. Each day from July 6-9, a new class of solar system small worlds was featured on the website: Monday-comets, Tuesday-asteroids, Wednesday-icy moons, and Thursday-dwarf planets. Then on Friday, July 10, nine scientists from Goddard Space Flight Center, Jet Propulsion Laboratory, Naval Research Laboratory, and Lunar and Planetary Institute gathered online for four hours to answer questions from the public via Facebook and Twitter. Throughout the afternoon the scientists worked closely with a social media expert and several summer interns to reply to inquirers and to archive their chats. By all accounts, Small Worlds Week was a huge success with 37 million potential views of the social media Q&A posts. The group plans to improve and replicate the program during the school year with a more classroom focus, and then to build and extend the program to be held every year. For more information, visit http:// sunearthday.nasa.gov or catch us on Twitter, #nasasww.

  2. On the Topologic Properties of River Networks

    NASA Astrophysics Data System (ADS)

    Sarker, S.; Singh, A.

    2017-12-01

    River network is an important landscape feature and has been studied extensively from a range of geomorphological and hydrological perspective. However, quantifying topologic dynamics and reorganization of river networks is becoming more and more challenging under changing natural and anthropogenic forcings. Here, we use a graph-theoretical approach to study topologic properties of natural and simulated river networks for a range of climatic and tectonic conditions. Among other metrics, we use betweeness and eigenvector centrality distributions computed using adjacency matrix of river networks and show their dependence on energy exponent γ that characterizes mechanism of erosional processes on a landscape. We further compare these topologic characteristics of landscape to geomorphic features such as slope-area curve and drainage density. Furthermore, we identify locations of critical nodes and links on a network as a function of energy exponent γ to understand network robustness and vulnerability under external attacks.

  3. Resistive dissipation and magnetic field topology in the stellar corona

    NASA Technical Reports Server (NTRS)

    Parker, E. N.

    1993-01-01

    Tangential discontinuities, or current sheets, in a magnetic field embedded in a fluid with vanishing resistivity are created by discontinuous fluid motion. Tangential discontinuities are also created when a magnetic field is allowed to relax to magnetostatic equilibrium after mixing by fluid motions (either continuous or discontinuous) into any but the simplest topologies. This paper shows by formal examples that the current sheets arising solely from discontinuous fluid motions do not contribute significantly to the dissipation of magnetic free energy when a small resistivity is introduced. Dissipation that is significant under coronal conditions occurs only by rapid reconnection, which arises when, and only when, the current sheets are required by the field topology. Hence it is topological dissipation that is primarily responsible for heating tenuous coronal gases in astronomical settings, whether the fluid displacements of the field are continuous or discontinuous.

  4. Topological Quantum Phase Transition and Local Topological Order in a Strongly Interacting Light-Matter System.

    PubMed

    Sarkar, Sujit

    2017-05-12

    An attempt is made to understand the topological quantum phase transition, emergence of relativistic modes and local topological order of light in a strongly interacting light-matter system. We study this system, in a one dimensional array of nonlinear cavities. Topological quantum phase transition occurs with massless excitation only for the finite detuning process. We present a few results based on the exact analytical calculations along with the physical explanations. We observe the emergence of massive Majorana fermion mode at the topological state, massless Majorana-Weyl fermion mode during the topological quantum phase transition and Dirac fermion mode for the non-topological state. Finally, we study the quantized Berry phase (topological order) and its connection to the topological number (winding number).

  5. Toric-boson model: Toward a topological quantum memory at finite temperature

    NASA Astrophysics Data System (ADS)

    Hamma, Alioscia; Castelnovo, Claudio; Chamon, Claudio

    2009-06-01

    We discuss the existence of stable topological quantum memory at finite temperature. At stake here is the fundamental question of whether it is, in principle, possible to store quantum information for macroscopic times without the intervention from the external world, that is, without error correction. We study the toric code in two dimensions with an additional bosonic field that couples to the defects, in the presence of a generic environment at finite temperature: the toric-boson model. Although the coupling constants for the bare model are not finite in the thermodynamic limit, the model has a finite spectrum. We show that in the topological phase, there is a finite temperature below which open strings are confined and therefore the lifetime of the memory can be made arbitrarily (polynomially) long in system size. The interaction with the bosonic field yields a long-range attractive force between the end points of open strings but leaves closed strings and topological order intact.

  6. Topological phases of topological-insulator thin films

    NASA Astrophysics Data System (ADS)

    Asmar, Mahmoud M.; Sheehy, Daniel E.; Vekhter, Ilya

    2018-02-01

    We study the properties of a thin film of topological insulator material. We treat the coupling between helical states at opposite surfaces of the film in the properly-adapted tunneling approximation, and show that the tunneling matrix element oscillates as a function of both the film thickness and the momentum in the plane of the film for Bi2Se3 and Bi2Te3 . As a result, while the magnitude of the matrix element at the center of the surface Brillouin zone gives the gap in the energy spectrum, the sign of the matrix element uniquely determines the topological properties of the film, as demonstrated by explicitly computing the pseudospin textures and the Chern number. We find a sequence of transitions between topological and nontopological phases, separated by semimetallic states, as the film thickness varies. In the topological phase, the edge states of the film always exist but only carry a spin current if the edge potentials break particle-hole symmetry. The edge states decay very slowly away from the boundary in Bi2Se3 , making Bi2Te3 , where this scale is shorter, a more promising candidate for the observation of these states. Our results hold for free-standing films as well as heterostructures with large-gap insulators.

  7. Markov models for fMRI correlation structure: Is brain functional connectivity small world, or decomposable into networks?

    PubMed

    Varoquaux, G; Gramfort, A; Poline, J B; Thirion, B

    2012-01-01

    Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set of mutually correlated regions that correspond to brain networks related to different cognitive functions. Yet graph-theoretical studies of neural connections give a different picture: that of a highly integrated system with small-world properties: local clustering but with short pathways across the complete structure. We examine the conditional independence properties of the fMRI signal, i.e. its Markov structure, to find realistic assumptions on the connectivity structure that are required to explain the observed functional connectivity. In particular we seek a decomposition of the Markov structure into segregated functional networks using decomposable graphs: a set of strongly-connected and partially overlapping cliques. We introduce a new method to efficiently extract such cliques on a large, strongly-connected graph. We compare methods learning different graph structures from functional connectivity by testing the goodness of fit of the model they learn on new data. We find that summarizing the structure as strongly-connected networks can give a good description only for very large and overlapping networks. These results highlight that Markov models are good tools to identify the structure of brain connectivity from fMRI signals, but for this purpose they must reflect the small-world properties of the underlying neural systems. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Fine topology and locally Minkowskian manifolds

    NASA Astrophysics Data System (ADS)

    Agrawal, Gunjan; Sinha, Soami Pyari

    2018-05-01

    Fine topology is one of the several well-known topologies of physical and mathematical relevance. In the present paper, it is obtained that the nonempty open sets of different dimensional Minkowski spaces with the fine topology are not homeomorphic. This leads to the introduction of a new class of manifolds. It turns out that the technique developed here is also applicable to some other topologies, namely, the s-topology, space topology, f-topology, and A-topology.

  9. Topological Quantum Buses: Coherent Quantum Information Transfer between Topological and Conventional Qubits

    NASA Astrophysics Data System (ADS)

    Bonderson, Parsa; Lutchyn, Roman M.

    2011-04-01

    We propose computing bus devices that enable quantum information to be coherently transferred between topological and conventional qubits. We describe a concrete realization of such a topological quantum bus acting between a topological qubit in a Majorana wire network and a conventional semiconductor double quantum dot qubit. Specifically, this device measures the joint (fermion) parity of these two different qubits by using the Aharonov-Casher effect in conjunction with an ancilliary superconducting flux qubit that facilitates the measurement. Such a parity measurement, together with the ability to apply Hadamard gates to the two qubits, allows one to produce states in which the topological and conventional qubits are maximally entangled and to teleport quantum states between the topological and conventional quantum systems.

  10. Topological quantum buses: coherent quantum information transfer between topological and conventional qubits.

    PubMed

    Bonderson, Parsa; Lutchyn, Roman M

    2011-04-01

    We propose computing bus devices that enable quantum information to be coherently transferred between topological and conventional qubits. We describe a concrete realization of such a topological quantum bus acting between a topological qubit in a Majorana wire network and a conventional semiconductor double quantum dot qubit. Specifically, this device measures the joint (fermion) parity of these two different qubits by using the Aharonov-Casher effect in conjunction with an ancilliary superconducting flux qubit that facilitates the measurement. Such a parity measurement, together with the ability to apply Hadamard gates to the two qubits, allows one to produce states in which the topological and conventional qubits are maximally entangled and to teleport quantum states between the topological and conventional quantum systems. © 2011 American Physical Society

  11. Topologies on directed graphs

    NASA Technical Reports Server (NTRS)

    Lieberman, R. N.

    1972-01-01

    Given a directed graph, a natural topology is defined and relationships between standard topological properties and graph theoretical concepts are studied. In particular, the properties of connectivity and separatedness are investigated. A metric is introduced which is shown to be related to separatedness. The topological notions of continuity and homeomorphism. A class of maps is studied which preserve both graph and topological properties. Applications involving strong maps and contractions are also presented.

  12. Topological data analyses and machine learning for detection, classification and characterization of atmospheric rivers

    NASA Astrophysics Data System (ADS)

    Muszynski, G.; Kashinath, K.; Wehner, M. F.; Prabhat, M.; Kurlin, V.

    2017-12-01

    We investigate novel approaches to detecting, classifying and characterizing extreme weather events, such as atmospheric rivers (ARs), in large high-dimensional climate datasets. ARs are narrow filaments of concentrated water vapour in the atmosphere that bring much of the precipitation in many mid-latitude regions. The precipitation associated with ARs is also responsible for major flooding events in many coastal regions of the world, including the west coast of the United States and western Europe. In this study we combine ideas from Topological Data Analysis (TDA) with Machine Learning (ML) for detecting, classifying and characterizing extreme weather events, like ARs. TDA is a new field that sits at the interface between topology and computer science, that studies "shape" - hidden topological structure - in raw data. It has been applied successfully in many areas of applied sciences, including complex networks, signal processing and image recognition. Using TDA we provide ARs with a shape characteristic as a new feature descriptor for the task of AR classification. In particular, we track the change in topology in precipitable water (integrated water vapour) fields using the Union-Find algorithm. We use the generated feature descriptors with ML classifiers to establish reliability and classification performance of our approach. We utilize the parallel toolkit for extreme climate events analysis (TECA: Petascale Pattern Recognition for Climate Science, Prabhat et al., Computer Analysis of Images and Patterns, 2015) for comparison (it is assumed that events identified by TECA is ground truth). Preliminary results indicate that our approach brings new insight into the study of ARs and provides quantitative information about the relevance of topological feature descriptors in analyses of a large climate datasets. We illustrate this method on climate model output and NCEP reanalysis datasets. Further, our method outperforms existing methods on detection and

  13. Topological Structure of the Space of Phenotypes: The Case of RNA Neutral Networks

    PubMed Central

    Aguirre, Jacobo; Buldú, Javier M.; Stich, Michael; Manrubia, Susanna C.

    2011-01-01

    The evolution and adaptation of molecular populations is constrained by the diversity accessible through mutational processes. RNA is a paradigmatic example of biopolymer where genotype (sequence) and phenotype (approximated by the secondary structure fold) are identified in a single molecule. The extreme redundancy of the genotype-phenotype map leads to large ensembles of RNA sequences that fold into the same secondary structure and can be connected through single-point mutations. These ensembles define neutral networks of phenotypes in sequence space. Here we analyze the topological properties of neutral networks formed by 12-nucleotides RNA sequences, obtained through the exhaustive folding of sequence space. A total of 412 sequences fragments into 645 subnetworks that correspond to 57 different secondary structures. The topological analysis reveals that each subnetwork is far from being random: it has a degree distribution with a well-defined average and a small dispersion, a high clustering coefficient, and an average shortest path between nodes close to its minimum possible value, i.e. the Hamming distance between sequences. RNA neutral networks are assortative due to the correlation in the composition of neighboring sequences, a feature that together with the symmetries inherent to the folding process explains the existence of communities. Several topological relationships can be analytically derived attending to structural restrictions and generic properties of the folding process. The average degree of these phenotypic networks grows logarithmically with their size, such that abundant phenotypes have the additional advantage of being more robust to mutations. This property prevents fragmentation of neutral networks and thus enhances the navigability of sequence space. In summary, RNA neutral networks show unique topological properties, unknown to other networks previously described. PMID:22028856

  14. CASP10-BCL::Fold efficiently samples topologies of large proteins.

    PubMed

    Heinze, Sten; Putnam, Daniel K; Fischer, Axel W; Kohlmann, Tim; Weiner, Brian E; Meiler, Jens

    2015-03-01

    During CASP10 in summer 2012, we tested BCL::Fold for prediction of free modeling (FM) and template-based modeling (TBM) targets. BCL::Fold assembles the tertiary structure of a protein from predicted secondary structure elements (SSEs) omitting more flexible loop regions early on. This approach enables the sampling of conformational space for larger proteins with more complex topologies. In preparation of CASP11, we analyzed the quality of CASP10 models throughout the prediction pipeline to understand BCL::Fold's ability to sample the native topology, identify native-like models by scoring and/or clustering approaches, and our ability to add loop regions and side chains to initial SSE-only models. The standout observation is that BCL::Fold sampled topologies with a GDT_TS score > 33% for 12 of 18 and with a topology score > 0.8 for 11 of 18 test cases de novo. Despite the sampling success of BCL::Fold, significant challenges still exist in clustering and loop generation stages of the pipeline. The clustering approach employed for model selection often failed to identify the most native-like assembly of SSEs for further refinement and submission. It was also observed that for some β-strand proteins model refinement failed as β-strands were not properly aligned to form hydrogen bonds removing otherwise accurate models from the pool. Further, BCL::Fold samples frequently non-natural topologies that require loop regions to pass through the center of the protein. © 2015 Wiley Periodicals, Inc.

  15. Structure Line Detection from LIDAR Point Clouds Using Topological Elevation Analysis

    NASA Astrophysics Data System (ADS)

    Lo, C. Y.; Chen, L. C.

    2012-07-01

    Airborne LIDAR point clouds, which have considerable points on object surfaces, are essential to building modeling. In the last two decades, studies have developed different approaches to identify structure lines using two main approaches, data-driven and modeldriven. These studies have shown that automatic modeling processes depend on certain considerations, such as used thresholds, initial value, designed formulas, and predefined cues. Following the development of laser scanning systems, scanning rates have increased and can provide point clouds with higher point density. Therefore, this study proposes using topological elevation analysis (TEA) to detect structure lines instead of threshold-dependent concepts and predefined constraints. This analysis contains two parts: data pre-processing and structure line detection. To preserve the original elevation information, a pseudo-grid for generating digital surface models is produced during the first part. The highest point in each grid is set as the elevation value, and its original threedimensional position is preserved. In the second part, using TEA, the structure lines are identified based on the topology of local elevation changes in two directions. Because structure lines can contain certain geometric properties, their locations have small relieves in the radial direction and steep elevation changes in the circular direction. Following the proposed approach, TEA can be used to determine 3D line information without selecting thresholds. For validation, the TEA results are compared with those of the region growing approach. The results indicate that the proposed method can produce structure lines using dense point clouds.

  16. Symmetry-protected topological insulator and its symmetry-enriched topologically ordered boundary

    NASA Astrophysics Data System (ADS)

    Wang, Juven; Wen, Xiao-Gang; Witten, Edward

    We propose a mechanism for achieving symmetry-enriched topologically ordered boundaries for symmetry-protected topological states, including those of topological insulators. Several different boundary phases and their phase transitions are considered, including confined phases, deconfined phases, symmetry-breaking, gapped and gapless phases. National Science Foundation PHY-1606531, Corning Glass Works Foundation Fellowship, NSF Grant DMR- 1506475 and NSFC 11274192, the BMO Financial Group and the John Templeton Foundation No. 39901.

  17. Observation of ultrahigh mobility surface states in a topological crystalline insulator by infrared spectroscopy

    DOE PAGES

    Wang, Ying; Luo, Guoyu; Liu, Junwei; ...

    2017-08-28

    Topological crystalline insulators possess metallic surface states protected by crystalline symmetry, which are a versatile platform for exploring topological phenomena and potential applications. However, progress in this field has been hindered by the challenge to probe optical and transport properties of the surface states owing to the presence of bulk carriers. Here, we report infrared reflectance measurements of a topological crystalline insulator, (001)-oriented Pb 1-xSn xSe in zero and high magnetic fields. We demonstrate that the far-infrared conductivity is unexpectedly dominated by the surface states as a result of their unique band structure and the consequent small infrared penetration depth.more » Moreover, our experiments yield a surface mobility of 40,000 cm 2 V -1 s -1, which is one of the highest reported values in topological materials, suggesting the viability of surface-dominated conduction in thin topological crystalline insulator crystals. These findings pave the way for exploring many exotic transport and optical phenomena and applications predicted for topological crystalline insulators.« less

  18. Observation of ultrahigh mobility surface states in a topological crystalline insulator by infrared spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Ying; Luo, Guoyu; Liu, Junwei

    Topological crystalline insulators possess metallic surface states protected by crystalline symmetry, which are a versatile platform for exploring topological phenomena and potential applications. However, progress in this field has been hindered by the challenge to probe optical and transport properties of the surface states owing to the presence of bulk carriers. Here, we report infrared reflectance measurements of a topological crystalline insulator, (001)-oriented Pb 1-xSn xSe in zero and high magnetic fields. We demonstrate that the far-infrared conductivity is unexpectedly dominated by the surface states as a result of their unique band structure and the consequent small infrared penetration depth.more » Moreover, our experiments yield a surface mobility of 40,000 cm 2 V -1 s -1, which is one of the highest reported values in topological materials, suggesting the viability of surface-dominated conduction in thin topological crystalline insulator crystals. These findings pave the way for exploring many exotic transport and optical phenomena and applications predicted for topological crystalline insulators.« less

  19. A quantitative approach to the topology of large-scale structure. [for galactic clustering computation

    NASA Technical Reports Server (NTRS)

    Gott, J. Richard, III; Weinberg, David H.; Melott, Adrian L.

    1987-01-01

    A quantitative measure of the topology of large-scale structure: the genus of density contours in a smoothed density distribution, is described and applied. For random phase (Gaussian) density fields, the mean genus per unit volume exhibits a universal dependence on threshold density, with a normalizing factor that can be calculated from the power spectrum. If large-scale structure formed from the gravitational instability of small-amplitude density fluctuations, the topology observed today on suitable scales should follow the topology in the initial conditions. The technique is illustrated by applying it to simulations of galaxy clustering in a flat universe dominated by cold dark matter. The technique is also applied to a volume-limited sample of the CfA redshift survey and to a model in which galaxies reside on the surfaces of polyhedral 'bubbles'. The topology of the evolved mass distribution and 'biased' galaxy distribution in the cold dark matter models closely matches the topology of the density fluctuations in the initial conditions. The topology of the observational sample is consistent with the random phase, cold dark matter model.

  20. Emergence of ultrafast sparsely synchronized rhythms and their responses to external stimuli in an inhomogeneous small-world complex neuronal network.

    PubMed

    Kim, Sang-Yoon; Lim, Woochang

    2017-09-01

    We consider an inhomogeneous small-world network (SWN) composed of inhibitory short-range (SR) and long-range (LR) interneurons, and investigate the effect of network architecture on emergence of synchronized brain rhythms by varying the fraction of LR interneurons p long . The betweenness centralities of the LR and SR interneurons (characterizing the potentiality in controlling communication between other interneurons) are distinctly different. Hence, in view of the betweenness, SWNs we consider are inhomogeneous, unlike the "canonical" Watts-Strogatz SWN with nearly the same betweenness centralities. For small p long , the load of communication traffic is much concentrated on a few LR interneurons. However, as p long is increased, the number of LR connections (coming from LR interneurons) increases, and then the load of communication traffic is less concentrated on LR interneurons, which leads to better efficiency of global communication between interneurons. Sparsely synchronized rhythms are thus found to emerge when passing a small critical value p long (c) (≃0.16). The population frequency of the sparsely synchronized rhythm is ultrafast (higher than 100 Hz), while the mean firing rate of individual interneurons is much lower (∼30 Hz) due to stochastic and intermittent neural discharges. These dynamical behaviors in the inhomogeneous SWN are also compared with those in the homogeneous Watts-Strogatz SWN, in connection with their network topologies. Particularly, we note that the main difference between the two types of SWNs lies in the distribution of betweenness centralities. Unlike the case of the Watts-Strogatz SWN, dynamical responses to external stimuli vary depending on the type of stimulated interneurons in the inhomogeneous SWN. We consider two cases of external time-periodic stimuli applied to sub-populations of the LR and SR interneurons, respectively. Dynamical responses (such as synchronization suppression and enhancement) to these two cases of

  1. Topology of three-dimensional separated flows

    NASA Technical Reports Server (NTRS)

    Tobak, M.; Peake, D. J.

    1981-01-01

    Based on the hypothesis that patterns of skin-friction lines and external streamlines reflect the properties of continuous vector fields, topology rules define a small number of singular points (nodes, saddle points, and foci) that characterize the patterns on the surface and on particular projections of the flow (e.g., the crossflow plane). The restricted number of singular points and the rules that they obey are considered as an organizing principle whose finite number of elements can be combined in various ways to connect together the properties common to all steady three dimensional viscous flows. Introduction of a distinction between local and global properties of the flow resolves an ambiguity in the proper definition of a three dimensional separated flow. Adoption of the notions of topological structure, structural stability, and bifurcation provides a framework to describe how three dimensional separated flows originate and succeed each other as the relevant parameters of the problem are varied.

  2. Measuring the topology of large-scale structure in the universe

    NASA Technical Reports Server (NTRS)

    Gott, J. Richard, III

    1988-01-01

    An algorithm for quantitatively measuring the topology of large-scale structure has now been applied to a large number of observational data sets. The present paper summarizes and provides an overview of some of these observational results. On scales significantly larger than the correlation length, larger than about 1200 km/s, the cluster and galaxy data are fully consistent with a sponge-like random phase topology. At a smoothing length of about 600 km/s, however, the observed genus curves show a small shift in the direction of a meatball topology. Cold dark matter (CDM) models show similar shifts at these scales but not generally as large as those seen in the data. Bubble models, with voids completely surrounded on all sides by wall of galaxies, show shifts in the opposite direction. The CDM model is overall the most successful in explaining the data.

  3. Measuring the topology of large-scale structure in the universe

    NASA Astrophysics Data System (ADS)

    Gott, J. Richard, III

    1988-11-01

    An algorithm for quantitatively measuring the topology of large-scale structure has now been applied to a large number of observational data sets. The present paper summarizes and provides an overview of some of these observational results. On scales significantly larger than the correlation length, larger than about 1200 km/s, the cluster and galaxy data are fully consistent with a sponge-like random phase topology. At a smoothing length of about 600 km/s, however, the observed genus curves show a small shift in the direction of a meatball topology. Cold dark matter (CDM) models show similar shifts at these scales but not generally as large as those seen in the data. Bubble models, with voids completely surrounded on all sides by wall of galaxies, show shifts in the opposite direction. The CDM model is overall the most successful in explaining the data.

  4. Topology of large-scale structure. IV - Topology in two dimensions

    NASA Technical Reports Server (NTRS)

    Melott, Adrian L.; Cohen, Alexander P.; Hamilton, Andrew J. S.; Gott, J. Richard, III; Weinberg, David H.

    1989-01-01

    In a recent series of papers, an algorithm was developed for quantitatively measuring the topology of the large-scale structure of the universe and this algorithm was applied to numerical models and to three-dimensional observational data sets. In this paper, it is shown that topological information can be derived from a two-dimensional cross section of a density field, and analytic expressions are given for a Gaussian random field. The application of a two-dimensional numerical algorithm for measuring topology to cross sections of three-dimensional models is demonstrated.

  5. Topological nearly entropy

    NASA Astrophysics Data System (ADS)

    Gulamsarwar, Syazwani; Salleh, Zabidin

    2017-08-01

    The purpose of this paper is to generalize the notions of Adler's topological entropy along with their several fundamental properties. A function f : X → Y is said to be R-map if f-1 (V) is regular open in X for every regular open set V in Y. Thus, we initiated a notion of topological nearly entropy for topological R-dynamical systems which is based on nearly compact relative to the space by using R-map.

  6. Emergence of Rich-Club Topology and Coordinated Dynamics in Development of Hippocampal Functional Networks In Vitro

    PubMed Central

    Charlesworth, Paul; Kitzbichler, Manfred G.; Paulsen, Ole

    2015-01-01

    Recent studies demonstrated that the anatomical network of the human brain shows a “rich-club” organization. This complex topological feature implies that highly connected regions, hubs of the large-scale brain network, are more densely interconnected with each other than expected by chance. Rich-club nodes were traversed by a majority of short paths between peripheral regions, underlining their potential importance for efficient global exchange of information between functionally specialized areas of the brain. Network hubs have also been described at the microscale of brain connectivity (so-called “hub neurons”). Their role in shaping synchronous dynamics and forming microcircuit wiring during development, however, is not yet fully understood. The present study aimed to investigate the role of hubs during network development, using multi-electrode arrays and functional connectivity analysis during spontaneous multi-unit activity (MUA) of dissociated primary mouse hippocampal neurons. Over the first 4 weeks in vitro, functional connectivity significantly increased in strength, density, and size, with mature networks demonstrating a robust modular and small-world topology. As expected by a “rich-get-richer” growth rule of network evolution, MUA graphs were found to form rich-clubs at an early stage in development (14 DIV). Later on, rich-club nodes were a consistent topological feature of MUA graphs, demonstrating high nodal strength, efficiency, and centrality. Rich-club nodes were also found to be crucial for MUA dynamics. They often served as broker of spontaneous activity flow, confirming that hub nodes and rich-clubs may play an important role in coordinating functional dynamics at the microcircuit level. PMID:25855164

  7. Stencil lithography of superconducting contacts on MBE-grown topological insulator thin films

    NASA Astrophysics Data System (ADS)

    Schüffelgen, Peter; Rosenbach, Daniel; Neumann, Elmar; Stehno, Martin P.; Lanius, Martin; Zhao, Jialin; Wang, Meng; Sheehan, Brendan; Schmidt, Michael; Gao, Bo; Brinkman, Alexander; Mussler, Gregor; Schäpers, Thomas; Grützmacher, Detlev

    2017-11-01

    Topological insulator (Bi0.06Sb0.94)2Te3 thin films grown by molecular beam epitaxy have been capped in-situ with a 2 nm Al film to conserve the pristine topological surface states. Subsequently, a shadow mask - structured by means of focus ion beam - was in-situ placed underneath the sample to deposit a thick layer of Al on well-defined microscopically small areas. The 2 nm thin Al layer fully oxidizes after exposure to air and in this way protects the TI surface from degradation. The thick Al layer remains metallic underneath a 3-4 nm thick native oxide layer and therefore serves as (super-) conducting contacts. Superconductor-Topological Insulator-Superconductor junctions with lateral dimensions in the nm range have then been fabricated via an alternative stencil lithography technique. Despite the in-situ deposition, transport measurements and transmission electron microscope analysis indicate a low transparency, due to an intermixed region at the interface between topological insulator thin film and metallic Al.

  8. Topologically Allowed Nonsixfold Vortices in a Sixfold Multiferroic Material: Observation and Classification

    DOE PAGES

    Cheng, Shaobo; Li, Jun; Han, Myung-Geun; ...

    2017-04-05

    Here, we report structural transformation of sixfold vortex domains into two-, four-, and eightfold vortices via a different type of topological defect in hexagonal manganites. Combining high-resolution electron microscopy and Landau-theory-based numerical simulations, we also investigate the remarkable atomic arrangement and the intertwined relationship between the vortex structures and the topological defects. The roles of their displacement field, formation temperature, and nucleation sites are revealed. All conceivable vortices in the system are topologically classified using homotopy group theory, and their origins are identified.

  9. Superconductivity and ferromagnetism in topological insulators

    NASA Astrophysics Data System (ADS)

    Zhang, Duming

    exist when topological insulators are interfaced with superconductors. The observation of Majorana fermions would not only be fundamentally important, but would also lead to applications in fault-tolerant topological quantum computation. By interfacing topological insulator nanoribbons with superconducting electrodes, we observe distinct signatures of proximity-induced superconductivity, which is found to be present in devices with channel lengths that are much longer than the normal transport characteristic lengths. This might suggest preferential coupling of the proximity effect to a ballistic surface channel of the topological insulator. In addition, when the electrodes are in the superconducting state, we observe periodic magnetoresistance oscillations which suggest the formation of vortices in the proximity-induced region of the nanoribbons. Our results demonstrate that proximity-induced superconductivity and vortices can be realized in our nanoribbon geometry, which accomplishes a first important step towards the search for Majorana fermions in condensed matter. In Chapter 5, I will discuss experiments on a magnetically-doped topological insulator (Mn-doped Bi2Se3) to induce a surface state gap. The metallic Dirac cone surface states of a topological insulator are expected to be protected against small perturbations by time-reversal symmetry. However, these surface states can be dramatically modified and a finite energy gap can be opened at the Dirac point by breaking the time-reversal symmetry via magnetic doping. The interplay between magnetism and topological surface states is predicted to yield novel phenomena of fundamental interest such as a topological magneto-electric effect, a quantized anomalous Hall effect, and the induction of magnetic monopoles. Our systematic measurements reveal a close correlation between the onset of ferromagnetism and quantum corrections to diffusive transport, which crosses over from the symplectic (weak anti-localization) to the

  10. Magnetic Topology of Coronal Hole Linkages

    NASA Technical Reports Server (NTRS)

    Titov, V. S.; Mikic, Z.; Linker, J. A.; Lionello, R.; Antiochos, S. K.

    2010-01-01

    In recent work, Antiochos and coworkers argued that the boundary between the open and closed field regions on the Sun can be extremely complex with narrow corridors of open ux connecting seemingly disconnected coronal holes from the main polar holes, and that these corridors may be the sources of the slow solar wind. We examine, in detail, the topology of such magnetic configurations using an analytical source surface model that allows for analysis of the eld with arbitrary resolution. Our analysis reveals three important new results: First, a coronal hole boundary can join stably to the separatrix boundary of a parasitic polarity region. Second, a single parasitic polarity region can produce multiple null points in the corona and, more important, separator lines connecting these points. Such topologies are extremely favorable for magnetic reconnection, because it can now occur over the entire length of the separators rather than being con ned to a small region around the nulls. Finally, the coronal holes are not connected by an open- eld corridor of finite width, but instead are linked by a singular line that coincides with the separatrix footprint of the parasitic polarity. We investigate how the topological features described above evolve in response to motion of the parasitic polarity region. The implications of our results for the sources of the slow solar wind and for coronal and heliospheric observations are discussed.

  11. Electronic structure of YbB 6 : Is it a topological insulator or not?

    DOE PAGES

    Kang, Chang -Jong; Denlinger, J. D.; Allen, J. W.; ...

    2016-03-17

    Here, to finally resolve the controversial issue of whether or not the electronic structure of YbB6 is nontrivially topological, we have made a combined study using angle-resolved photoemission spectroscopy (ARPES) of the nonpolar (110) surface and density functional theory (DFT). The flat-band conditions of the (110) ARPES avoid the strong band bending effects of the polar (001) surface and definitively show that YbB 6 has a topologically trivial B 2p–Yb 5d semiconductor band gap of ~0.3 eV. Accurate determination of the low energy band topology in DFT requires the use of a modified Becke-Johnson exchange potential incorporating spin-orbit coupling andmore » an on-site Yb 4f Coulomb interaction U as large as 7 eV. The DFT result, confirmed by a more precise GW band calculation, is similar to that of a small gap non-Kondo nontopological semiconductor. Additionally, the pressure-dependent electronic structure of YbB 6 is investigated theoretically and found to transform into a p–d overlap semimetal with small Yb mixed valency.« less

  12. Reconfigurable topological photonic crystal

    NASA Astrophysics Data System (ADS)

    Shalaev, Mikhail I.; Desnavi, Sameerah; Walasik, Wiktor; Litchinitser, Natalia M.

    2018-02-01

    Topological insulators are materials that conduct on the surface and insulate in their interior due to non-trivial topology of the band structure. The edge states on the interface between topological (non-trivial) and conventional (trivial) insulators are topologically protected from scattering due to structural defects and disorders. Recently, it was shown that photonic crystals (PCs) can serve as a platform for realizing a scatter-free propagation of light waves. In conventional PCs, imperfections, structural disorders, and surface roughness lead to significant losses. The breakthrough in overcoming these problems is likely to come from the synergy of the topological PCs and silicon-based photonics technology that enables high integration density, lossless propagation, and immunity to fabrication imperfections. For many applications, reconfigurability and capability to control the propagation of these non-trivial photonic edge states is essential. One way to facilitate such dynamic control is to use liquid crystals (LCs), which allow to modify the refractive index with external electric field. Here, we demonstrate dynamic control of topological edge states by modifying the refractive index of a LC background medium. Background index is changed depending on the orientation of a LC, while preserving the topology of the system. This results in a change of the spectral position of the photonic bandgap and the topological edge states. The proposed concept might be implemented using conventional semiconductor technology, and can be used for robust energy transport in integrated photonic devices, all-optical circuity, and optical communication systems.

  13. Topological mosaics in moiré superlattices of van der Waals heterobilayers

    NASA Astrophysics Data System (ADS)

    Tong, Qingjun; Yu, Hongyi; Zhu, Qizhong; Wang, Yong; Xu, Xiaodong; Yao, Wang

    2017-04-01

    Van der Waals (vdW) heterostructures formed by two-dimensional atomic crystals provide a powerful approach towards designer condensed matter systems. Incommensurate heterobilayers with small twisting and/or lattice mismatch lead to the interesting concept of moiré superlattices, where the atomic registry is locally indistinguishable from commensurate bilayers but has local-to-local variation over long range. Here we show that such moiré superlattices can lead to periodic modulation of local topological order in vdW heterobilayers formed by two massive Dirac materials. By tuning the vdW heterojunction from normal to the inverted type-II regime via an interlayer bias, the commensurate heterobilayer can become a topological insulator (TI), depending on the interlayer hybridization controlled by the atomic registry between the vdW layers. This results in a mosaic pattern of TI regions and normal insulator (NI) regions in moiré superlattices, where topologically protected helical modes exist at the TI/NI phase boundaries. By using symmetry-based k .p and tight-binding models, we predict that this topological phenomenon can be present in inverted transition metal dichalcogenides heterobilayers. Our work points to a new means of realizing programmable and electrically switchable topological superstructures from two-dimensional arrays of TI nano-dots to one-dimensional arrays of TI nano-stripes.

  14. Topological crystalline magnets: Symmetry-protected topological phases of fermions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Watanabe, Haruki; Fu, Liang

    Here, we introduce a novel class of interaction-enabled topological crystalline insulators in two- and three-dimensional electronic systems, which we call “topological crystalline magnet.” It is protected by the product of the time-reversal symmetry T and a mirror symmetry or a rotation symmetry R. A topological crystalline magnet exhibits two intriguing features: (i) it cannot be adiabatically connected to any Slater insulator and (ii) the edge state is robust against coupling electrons to the edge. These features are protected by the anomalous symmetry transformation property ( RT) 2 = -1 of the edge state. Finally, an anisotropic response to the externalmore » magnetic field can be an experimental signature.« less

  15. Topological crystalline magnets: Symmetry-protected topological phases of fermions

    DOE PAGES

    Watanabe, Haruki; Fu, Liang

    2017-02-27

    Here, we introduce a novel class of interaction-enabled topological crystalline insulators in two- and three-dimensional electronic systems, which we call “topological crystalline magnet.” It is protected by the product of the time-reversal symmetry T and a mirror symmetry or a rotation symmetry R. A topological crystalline magnet exhibits two intriguing features: (i) it cannot be adiabatically connected to any Slater insulator and (ii) the edge state is robust against coupling electrons to the edge. These features are protected by the anomalous symmetry transformation property ( RT) 2 = -1 of the edge state. Finally, an anisotropic response to the externalmore » magnetic field can be an experimental signature.« less

  16. Topology Optimization of Lightweight Lattice Structural Composites Inspired by Cuttlefish Bone

    NASA Astrophysics Data System (ADS)

    Hu, Zhong; Gadipudi, Varun Kumar; Salem, David R.

    2018-03-01

    Lattice structural composites are of great interest to various industries where lightweight multifunctionality is important, especially aerospace. However, strong coupling among the composition, microstructure, porous topology, and fabrication of such materials impedes conventional trial-and-error experimental development. In this work, a discontinuous carbon fiber reinforced polymer matrix composite was adopted for structural design. A reliable and robust design approach for developing lightweight multifunctional lattice structural composites was proposed, inspired by biomimetics and based on topology optimization. Three-dimensional periodic lattice blocks were initially designed, inspired by the cuttlefish bone microstructure. The topologies of the three-dimensional periodic blocks were further optimized by computer modeling, and the mechanical properties of the topology optimized lightweight lattice structures were characterized by computer modeling. The lattice structures with optimal performance were identified.

  17. Topological Electride Y2C.

    PubMed

    Huang, Huaqing; Jin, Kyung-Hwan; Zhang, Shunhong; Liu, Feng

    2018-03-14

    Two-dimensional (2D) electrides are layered ionic crystals in which anionic electrons are confined in the interlayer space. Here, we report a discovery of nontrivial [Formula: see text] topology in the electronic structures of 2D electride Y 2 C. Based on first-principles calculations, we found a topological [Formula: see text] invariant of (1; 111) for the bulk band and topologically protected surface states in the surfaces of Y 2 C, signifying its nontrivial electronic topology. We suggest a spin-resolved angle-resolved photoemission spectroscopy (ARPES) measurement to detect the unique helical spin texture of the spin-polarized topological surface state, which will provide characteristic evidence for the nontrivial electronic topology of Y 2 C. Furthermore, the coexistence of 2D surface electride states and topological surface state enables us to explain the outstanding discrepancy between the recent ARPES experiments and theoretical calculations. Our findings establish a preliminary link between the electride in chemistry and the band topology in condensed-matter physics, which are expected to inspire further interdisciplinary research between these fields.

  18. Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis.

    PubMed

    Li, Cheuk Wun; Menconi, Francesca; Osman, Roman; Mezei, Mihaly; Jacobson, Eric M; Concepcion, Erlinda; David, Chella S; Kastrinsky, David B; Ohlmeyer, Michael; Tomer, Yaron

    2016-02-19

    We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) peptides that bound to DRβ1-Arg74. We hypothesized that blocking the binding of these peptides to DRβ1-Arg74 could block the continuous T-cell activation in thyroiditis needed to maintain the autoimmune response to the thyroid. The aim of the current study was to identify small molecules that can block T-cell activation by Tg peptides presented within DRβ1-Arg74 pockets. We screened a large and diverse library of compounds and identified one compound, cepharanthine that was able to block peptide binding to DRβ1-Arg74. We then showed that Tg.2098 is the dominant peptide when inducing experimental autoimmune thyroiditis (EAT) in NOD mice expressing human DRβ1-Arg74. Furthermore, cepharanthine blocked T-cell activation by thyroglobulin peptides, in particular Tg.2098 in mice that were induced with EAT. For the first time we identified a small molecule that can block Tg peptide binding and presentation to T-cells in autoimmune thyroiditis. If confirmed cepharanthine could potentially have a role in treating human AITD. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Brain structural network topological alterations of the left prefrontal and limbic cortex in psychogenic erectile dysfunction.

    PubMed

    Chen, Jianhuai; Chen, Yun; Gao, Qingqiang; Chen, Guotao; Dai, Yutian; Yao, Zhijian; Lu, Qing

    2018-05-01

    Despite increasing understanding of the cerebral functional changes and structural abnormalities in erectile dysfunction, alterations in the topological organization of brain networks underlying psychogenic erectile dysfunction remain unclear. Here, based on the diffusion tensor image data of 25 patients and 26 healthy controls, we investigated the topological organization of brain structural networks and its correlations with the clinical variables using the graph theoretical analysis. Patients displayed a preserved overall small-world organization and exhibited a less connectivity strength in the left inferior frontal gyrus, amygdale and the right inferior temporal gyrus. Moreover, an abnormal hub pattern was observed in patients, which might disturb the information interactions of the remaining brain network. Additionally, the clustering coefficient of the left hippocampus was positively correlated with the duration of patients and the normalized betweenness centrality of the right anterior cingulate gyrus and the left calcarine fissure were negatively correlated with the sum scores of the 17-item Hamilton Depression Rating Scale. These findings suggested that the damaged white matter and the abnormal hub distribution of the left prefrontal and limbic cortex might contribute to the pathogenesis of psychogenic erectile dysfunction and provided new insights into the understanding of the pathophysiological mechanisms of psychogenic erectile dysfunction.

  20. Accurate Classification of RNA Structures Using Topological Fingerprints

    PubMed Central

    Li, Kejie; Gribskov, Michael

    2016-01-01

    While RNAs are well known to possess complex structures, functionally similar RNAs often have little sequence similarity. While the exact size and spacing of base-paired regions vary, functionally similar RNAs have pronounced similarity in the arrangement, or topology, of base-paired stems. Furthermore, predicted RNA structures often lack pseudoknots (a crucial aspect of biological activity), and are only partially correct, or incomplete. A topological approach addresses all of these difficulties. In this work we describe each RNA structure as a graph that can be converted to a topological spectrum (RNA fingerprint). The set of subgraphs in an RNA structure, its RNA fingerprint, can be compared with the fingerprints of other RNA structures to identify and correctly classify functionally related RNAs. Topologically similar RNAs can be identified even when a large fraction, up to 30%, of the stems are omitted, indicating that highly accurate structures are not necessary. We investigate the performance of the RNA fingerprint approach on a set of eight highly curated RNA families, with diverse sizes and functions, containing pseudoknots, and with little sequence similarity–an especially difficult test set. In spite of the difficult test set, the RNA fingerprint approach is very successful (ROC AUC > 0.95). Due to the inclusion of pseudoknots, the RNA fingerprint approach both covers a wider range of possible structures than methods based only on secondary structure, and its tolerance for incomplete structures suggests that it can be applied even to predicted structures. Source code is freely available at https://github.rcac.purdue.edu/mgribsko/XIOS_RNA_fingerprint. PMID:27755571

  1. Phonon-Induced Topological Transition to a Type-II Weyl Semimetal

    NASA Astrophysics Data System (ADS)

    Wang, Lin-Lin; Jo, Na Hyun; Wu, Yun; Kaminski, Adam; Canfield, Paul C.; Johnson, Duane D.

    The emergence of topological quantum states requires certain combinations of crystalline symmetry with or without time reversal symmetry. Without restricting to searches for crystal structures with non-symmorphic symmetry operations in the space groups, we have studied the interplay between crystal symmetry, atomic displacements (lattice vibration), band degeneracy and topology. For a system with a full gap opening between the two band manifolds near the Fermi energy, we show that small atomic displacements (accessible via optical phonons near room temperature) can lower the symmetry to induce type-II Weyl points at the boundary between a pair of closely-lying electron and hole pockets. DOE Ames Laboratory LDRD.

  2. Cellular automata simulation of topological effects on the dynamics of feed-forward motifs

    PubMed Central

    Apte, Advait A; Cain, John W; Bonchev, Danail G; Fong, Stephen S

    2008-01-01

    Background Feed-forward motifs are important functional modules in biological and other complex networks. The functionality of feed-forward motifs and other network motifs is largely dictated by the connectivity of the individual network components. While studies on the dynamics of motifs and networks are usually devoted to the temporal or spatial description of processes, this study focuses on the relationship between the specific architecture and the overall rate of the processes of the feed-forward family of motifs, including double and triple feed-forward loops. The search for the most efficient network architecture could be of particular interest for regulatory or signaling pathways in biology, as well as in computational and communication systems. Results Feed-forward motif dynamics were studied using cellular automata and compared with differential equation modeling. The number of cellular automata iterations needed for a 100% conversion of a substrate into a target product was used as an inverse measure of the transformation rate. Several basic topological patterns were identified that order the specific feed-forward constructions according to the rate of dynamics they enable. At the same number of network nodes and constant other parameters, the bi-parallel and tri-parallel motifs provide higher network efficacy than single feed-forward motifs. Additionally, a topological property of isodynamicity was identified for feed-forward motifs where different network architectures resulted in the same overall rate of the target production. Conclusion It was shown for classes of structural motifs with feed-forward architecture that network topology affects the overall rate of a process in a quantitatively predictable manner. These fundamental results can be used as a basis for simulating larger networks as combinations of smaller network modules with implications on studying synthetic gene circuits, small regulatory systems, and eventually dynamic whole-cell models

  3. Topological bound states of a quantum walk with cold atoms

    NASA Astrophysics Data System (ADS)

    Mugel, Samuel; Celi, Alessio; Massignan, Pietro; Asbóth, János K.; Lewenstein, Maciej; Lobo, Carlos

    2016-08-01

    We suggest a method for engineering a quantum walk, with cold atoms as walkers, which presents topologically nontrivial properties. We derive the phase diagram, and show that we are able to produce a boundary between topologically distinct phases using the finite beam width of the applied lasers. A topologically protected bound state can then be observed, which is pinned to the interface and is robust to perturbations. We show that it is possible to identify this bound state by averaging over spin sensitive measures of the atom's position, based on the spin distribution that these states display. Interestingly, there exists a parameter regime in which our system maps on to the Creutz ladder.

  4. Exploring 4D quantum Hall physics with a 2D topological charge pump

    NASA Astrophysics Data System (ADS)

    Lohse, Michael; Schweizer, Christian; Price, Hannah M.; Zilberberg, Oded; Bloch, Immanuel

    2018-01-01

    The discovery of topological states of matter has greatly improved our understanding of phase transitions in physical systems. Instead of being described by local order parameters, topological phases are described by global topological invariants and are therefore robust against perturbations. A prominent example is the two-dimensional (2D) integer quantum Hall effect: it is characterized by the first Chern number, which manifests in the quantized Hall response that is induced by an external electric field. Generalizing the quantum Hall effect to four-dimensional (4D) systems leads to the appearance of an additional quantized Hall response, but one that is nonlinear and described by a 4D topological invariant—the second Chern number. Here we report the observation of a bulk response with intrinsic 4D topology and demonstrate its quantization by measuring the associated second Chern number. By implementing a 2D topological charge pump using ultracold bosonic atoms in an angled optical superlattice, we realize a dynamical version of the 4D integer quantum Hall effect. Using a small cloud of atoms as a local probe, we fully characterize the nonlinear response of the system via in situ imaging and site-resolved band mapping. Our findings pave the way to experimentally probing higher-dimensional quantum Hall systems, in which additional strongly correlated topological phases, exotic collective excitations and boundary phenomena such as isolated Weyl fermions are predicted.

  5. Exploring 4D quantum Hall physics with a 2D topological charge pump.

    PubMed

    Lohse, Michael; Schweizer, Christian; Price, Hannah M; Zilberberg, Oded; Bloch, Immanuel

    2018-01-03

    The discovery of topological states of matter has greatly improved our understanding of phase transitions in physical systems. Instead of being described by local order parameters, topological phases are described by global topological invariants and are therefore robust against perturbations. A prominent example is the two-dimensional (2D) integer quantum Hall effect: it is characterized by the first Chern number, which manifests in the quantized Hall response that is induced by an external electric field. Generalizing the quantum Hall effect to four-dimensional (4D) systems leads to the appearance of an additional quantized Hall response, but one that is nonlinear and described by a 4D topological invariant-the second Chern number. Here we report the observation of a bulk response with intrinsic 4D topology and demonstrate its quantization by measuring the associated second Chern number. By implementing a 2D topological charge pump using ultracold bosonic atoms in an angled optical superlattice, we realize a dynamical version of the 4D integer quantum Hall effect. Using a small cloud of atoms as a local probe, we fully characterize the nonlinear response of the system via in situ imaging and site-resolved band mapping. Our findings pave the way to experimentally probing higher-dimensional quantum Hall systems, in which additional strongly correlated topological phases, exotic collective excitations and boundary phenomena such as isolated Weyl fermions are predicted.

  6. Topologically massive magnetic monopoles

    NASA Astrophysics Data System (ADS)

    Aliev, A. N.; Nutku, Y.; Saygili, K.

    2000-10-01

    We show that in the Maxwell-Chern-Simons theory of topologically massive electrodynamics the Dirac string of a monopole becomes a cone in anti-de Sitter space with the opening angle of the cone determined by the topological mass, which in turn is related to the square root of the cosmological constant. This proves to be an example of a physical system, a priori completely unrelated to gravity, which nevertheless requires curved spacetime for its very existence. We extend this result to topologically massive gravity coupled to topologically massive electrodynamics within the framework of the theory of Deser, Jackiw and Templeton. The two-component spinor formalism, which is a Newman-Penrose type approach for three dimensions, is extended to include both the electrodynamical and gravitational topologically massive field equations. Using this formalism exact solutions of the coupled Deser-Jackiw-Templeton and Maxwell-Chern-Simons field equations for a topologically massive monopole are presented. These are homogeneous spaces with conical deficit. Pure Einstein gravity coupled to the Maxwell-Chern-Simons field does not admit such a monopole solution.

  7. Recipe for Topological Polaritons

    NASA Astrophysics Data System (ADS)

    Karzig, Torsten; Bardyn, Charles-Edouard; Lindner, Netanel; Refael, Gil

    2015-03-01

    The interaction between light and matter can give rise to novel topological states. This principle was recently exemplified in Floquet topological insulators, where classical light was used to induce a topological electronic band structure. Here, in contrast, we show that mixing single photons with excitons can result in new topological polaritonic states -- or ``topolaritons''. Taken separately, the underlying photons and excitons are topologically trivial. Combined appropriately, however, they give rise to non-trivial polaritonic bands with chiral edge modes allowing for unidirectional polariton propagation. The main ingredient in our construction is an exciton-photon coupling with a phase that winds in momentum space. We demonstrate how this winding emerges from spin-orbit coupling in the electronic system and an applied Zeeman field. We discuss the requirements for obtaining a sizable topological gap in the polariton spectrum. Funded by the Institute for Quantum Information and Matter, the Bi-National Science Foundation and I-Core: the Israeli Excellence Center ``Circle of Light'', and Darpa under funding for FENA, and the Swiss National Science Foundation.

  8. Topological nodal superconducting phases and topological phase transition in the hyperhoneycomb lattice

    NASA Astrophysics Data System (ADS)

    Bouhon, Adrien; Schmidt, Johann; Black-Schaffer, Annica M.

    2018-03-01

    We establish the topology of the spin-singlet superconducting states in the bare hyperhoneycomb lattice, and we derive analytically the full phase diagram using only symmetry and topology in combination with simple energy arguments. The phase diagram is dominated by two states preserving time-reversal symmetry. We find a line-nodal state dominating at low doping levels that is topologically nontrivial and exhibits surface Majorana flatbands, which we show perfectly match the bulk-boundary correspondence using the Berry phase approach. At higher doping levels, we find a fully gapped state with trivial topology. By analytically calculating the topological invariant of the nodal lines, we derive the critical point between the line-nodal and fully gapped states as a function of both pairing parameters and doping. We find that the line-nodal state is favored not only at lower doping levels but also if symmetry-allowed deformations of the lattice are present. Adding simple energy arguments, we establish that a fully gapped state with broken time-reversal symmetry likely appears covering the actual phase transition. We find this fully gapped state to be topologically trivial, while we find an additional point-nodal state at very low doing levels that also break time-reversal symmetry and has nontrivial topology with associated Fermi surface arcs. We eventually address the robustness of the phase diagram to generalized models also including adiabatic spin-orbit coupling, and we show how all but the point-nodal state are reasonably stable.

  9. Topology mapping to characterize cyanobacterial bicarbonate transporters: BicA (SulP/SLC26 family) and SbtA.

    PubMed

    Price, G Dean; Howitt, Susan M

    2014-09-01

    This mini-review addresses advances in understanding the transmembrane topologies of two unrelated, single-subunit bicarbonate transporters from cyanobacteria, namely BicA and SbtA. BicA is a Na(+)-dependent bicarbonate transporter that belongs to the SulP/SLC26 family that is widespread in both eukaryotes and prokaryotes. Topology mapping of BicA via the phoA/lacZ fusion reporter method identified 12 transmembrane helices with an unresolved hydrophobic region just beyond helix 8. Re-interpreting this data in the light of a recent topology study on rat prestin leads to a consensus topology of 14 transmembrane domains with a 7+7 inverted repeat structure. SbtA is also a Na(+)-dependent bicarbonate transporter, but of considerably higher affinity (Km 2-5 μM versus >100 μM for BicA). Whilst SbtA is widespread in cyanobacteria and a few bacteria, it appears to be absent from eukaryotes. Topology mapping of SbtA via the phoA/lacZ fusion reporter method identified 10 transmembrane helices. The topology consists of a 5+5 inverted repeat, with the two repeats separated by a large intracellular loop. The unusual location of the N and C-termini outside the cell raises the possibility that SbtA forms a novel fold, not so far identified by structural and topological studies on transport proteins.

  10. Topological properties of robust biological and computational networks

    PubMed Central

    Navlakha, Saket; He, Xin; Faloutsos, Christos; Bar-Joseph, Ziv

    2014-01-01

    Network robustness is an important principle in biology and engineering. Previous studies of global networks have identified both redundancy and sparseness as topological properties used by robust networks. By focusing on molecular subnetworks, or modules, we show that module topology is tightly linked to the level of environmental variability (noise) the module expects to encounter. Modules internal to the cell that are less exposed to environmental noise are more connected and less robust than external modules. A similar design principle is used by several other biological networks. We propose a simple change to the evolutionary gene duplication model which gives rise to the rich range of module topologies observed within real networks. We apply these observations to evaluate and design communication networks that are specifically optimized for noisy or malicious environments. Combined, joint analysis of biological and computational networks leads to novel algorithms and insights benefiting both fields. PMID:24789562

  11. Topological effects in quantum mechanics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peshkin, M.; Lipkin, H.J.

    We completed our analysis of experiments, some completed, some planned, and some only conceptual at present, that purport to demonstrate new kinds of non-local and topological effects in the interaction of a neutron with an external electromagnetic field. In the Aharonov-Casher effect (AC), the neutron interacts with an electric field and in the Scalar Aharonov-Bohm effect (SAB) the neutron interacts with a magnetic field. In both cases, the geometry can be arranged so that there is no force on the neutron but an interference experiment nevertheless finds a phase shift proportional to the applied field and to the neutron`s magneticmore » moment. Previously, we showed that the accepted interpretation of these phenomena as topological effects due to a non-local interaction between the neutron and the electromagnetic field is incorrect. Both AC and SAB follow from local torques on the neutron whose expectation values vanish at every instant but which have non-vanishing effect on the measurable spin-correlation variables S(t) = (1/2) [{sigma}{sub x}{sigma}{sub x}(t) + {sigma}{sub y}(0){sigma}{sub y}(t) + h.c.] and V(t) = [{sigma}{sub x}(0){sigma}{sub y}(t) - {sigma}{sub y}(0){sigma}{sub x}(t) + h.c.]. We have now completed this work by observing that a criterion often used for identifying a topological effect, energy independence of the phase shift between two arms of an interferometer, is only a necessary condition, and by describing a phase shifter which obeys the energy-independence condition but whose interaction with the neutron is neither topological nor even non-local.« less

  12. Topological states of condensed matter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Jing; Zhang, Shou-Cheng

    Topological states of quantum matter have been investigated intensively in recent years in materials science and condensed matter physics. The field developed explosively largely because of the precise theoretical predictions, well-controlled materials processing, and novel characterization techniques. In this Perspective, we review recent progress in topological insulators, the quantum anomalous Hall effect, chiral topological superconductors, helical topological superconductors and Weyl semimetals.

  13. Topological states of condensed matter

    DOE PAGES

    Wang, Jing; Zhang, Shou-Cheng

    2017-10-25

    Topological states of quantum matter have been investigated intensively in recent years in materials science and condensed matter physics. The field developed explosively largely because of the precise theoretical predictions, well-controlled materials processing, and novel characterization techniques. In this Perspective, we review recent progress in topological insulators, the quantum anomalous Hall effect, chiral topological superconductors, helical topological superconductors and Weyl semimetals.

  14. Nanoscale electron transport at the surface of a topological insulator.

    PubMed

    Bauer, Sebastian; Bobisch, Christian A

    2016-04-21

    The use of three-dimensional topological insulators for disruptive technologies critically depends on the dissipationless transport of electrons at the surface, because of the suppression of backscattering at defects. However, in real devices, defects are unavoidable and scattering at angles other than 180° is allowed for such materials. Until now, this has been studied indirectly by bulk measurements and by the analysis of the local density of states in close vicinity to defect sites. Here, we directly measure the nanoscale voltage drop caused by the scattering at step edges, which occurs if a lateral current flows along a three-dimensional topological insulator. The experiments were performed using scanning tunnelling potentiometry for thin Bi2Se3 films. So far, the observed voltage drops are small because of large contributions of the bulk to the electronic transport. However, for the use of ideal topological insulating thin films in devices, these contributions would play a significant role.

  15. Nanoscale electron transport at the surface of a topological insulator

    NASA Astrophysics Data System (ADS)

    Bauer, Sebastian; Bobisch, Christian A.

    2016-04-01

    The use of three-dimensional topological insulators for disruptive technologies critically depends on the dissipationless transport of electrons at the surface, because of the suppression of backscattering at defects. However, in real devices, defects are unavoidable and scattering at angles other than 180° is allowed for such materials. Until now, this has been studied indirectly by bulk measurements and by the analysis of the local density of states in close vicinity to defect sites. Here, we directly measure the nanoscale voltage drop caused by the scattering at step edges, which occurs if a lateral current flows along a three-dimensional topological insulator. The experiments were performed using scanning tunnelling potentiometry for thin Bi2Se3 films. So far, the observed voltage drops are small because of large contributions of the bulk to the electronic transport. However, for the use of ideal topological insulating thin films in devices, these contributions would play a significant role.

  16. Strong gravity and structure of topological solitons

    NASA Astrophysics Data System (ADS)

    Rybakov, Yu. P.

    The unification of Skyrme and Faddeev chiral models describing baryons and leptons respectively as topological solitons is suggested within the framework of 16-spinor field ψ = ψ1 ⊕ ψ2 nonlinear model containing two 8-semispinors ψ1 and ψ2. Using Brioschi identity for 8-spinors and special structure of the Higgs potential V implying the spontaneous symmetry breaking, it is possible to realize topological soliton-like excitations of two kinds due to the choice of S2- or S3- manifolds as phase spaces. The interactions with electromagnetic, Yang--Mills and gravitational fields are exhibited through the extention of derivatives via gauge invariance principle. Specific inclusion in the Higgs potential of the Kretschmann gravitational invariant K = RμνσλRμνσλ/48 permits one to obtain the strong gravity behavior at small distances and guarantee the correspondence with Quantum Mechanics at large distances.

  17. Scale-space measures for graph topology link protein network architecture to function.

    PubMed

    Hulsman, Marc; Dimitrakopoulos, Christos; de Ridder, Jeroen

    2014-06-15

    The network architecture of physical protein interactions is an important determinant for the molecular functions that are carried out within each cell. To study this relation, the network architecture can be characterized by graph topological characteristics such as shortest paths and network hubs. These characteristics have an important shortcoming: they do not take into account that interactions occur across different scales. This is important because some cellular functions may involve a single direct protein interaction (small scale), whereas others require more and/or indirect interactions, such as protein complexes (medium scale) and interactions between large modules of proteins (large scale). In this work, we derive generalized scale-aware versions of known graph topological measures based on diffusion kernels. We apply these to characterize the topology of networks across all scales simultaneously, generating a so-called graph topological scale-space. The comprehensive physical interaction network in yeast is used to show that scale-space based measures consistently give superior performance when distinguishing protein functional categories and three major types of functional interactions-genetic interaction, co-expression and perturbation interactions. Moreover, we demonstrate that graph topological scale spaces capture biologically meaningful features that provide new insights into the link between function and protein network architecture. Matlab(TM) code to calculate the scale-aware topological measures (STMs) is available at http://bioinformatics.tudelft.nl/TSSA © The Author 2014. Published by Oxford University Press.

  18. Floquet topological insulators for sound

    NASA Astrophysics Data System (ADS)

    Fleury, Romain; Khanikaev, Alexander B.; Alù, Andrea

    2016-06-01

    The unique conduction properties of condensed matter systems with topological order have recently inspired a quest for the similar effects in classical wave phenomena. Acoustic topological insulators, in particular, hold the promise to revolutionize our ability to control sound, allowing for large isolation in the bulk and broadband one-way transport along their edges, with topological immunity against structural defects and disorder. So far, these fascinating properties have been obtained relying on moving media, which may introduce noise and absorption losses, hindering the practical potential of topological acoustics. Here we overcome these limitations by modulating in time the acoustic properties of a lattice of resonators, introducing the concept of acoustic Floquet topological insulators. We show that acoustic waves provide a fertile ground to apply the anomalous physics of Floquet topological insulators, and demonstrate their relevance for a wide range of acoustic applications, including broadband acoustic isolation and topologically protected, nonreciprocal acoustic emitters.

  19. Floquet topological insulators for sound

    PubMed Central

    Fleury, Romain; Khanikaev, Alexander B; Alù, Andrea

    2016-01-01

    The unique conduction properties of condensed matter systems with topological order have recently inspired a quest for the similar effects in classical wave phenomena. Acoustic topological insulators, in particular, hold the promise to revolutionize our ability to control sound, allowing for large isolation in the bulk and broadband one-way transport along their edges, with topological immunity against structural defects and disorder. So far, these fascinating properties have been obtained relying on moving media, which may introduce noise and absorption losses, hindering the practical potential of topological acoustics. Here we overcome these limitations by modulating in time the acoustic properties of a lattice of resonators, introducing the concept of acoustic Floquet topological insulators. We show that acoustic waves provide a fertile ground to apply the anomalous physics of Floquet topological insulators, and demonstrate their relevance for a wide range of acoustic applications, including broadband acoustic isolation and topologically protected, nonreciprocal acoustic emitters. PMID:27312175

  20. Topological Acoustic Delay Line

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiwang; Tian, Ye; Cheng, Ying; Wei, Qi; Liu, Xiaojun; Christensen, Johan

    2018-03-01

    Topological protected wave engineering in artificially structured media is at the frontier of ongoing metamaterials research that is inspired by quantum mechanics. Acoustic analogues of electronic topological insulators have recently led to a wealth of new opportunities in manipulating sound propagation with strikingly unconventional acoustic edge modes immune to backscattering. Earlier fabrications of topological insulators are characterized by an unreconfigurable geometry and a very narrow frequency response, which severely hinders the exploration and design of useful devices. Here we establish topologically protected sound in reconfigurable phononic crystals that can be switched on and off simply by rotating its three-legged "atoms" without altering the lattice structure. In particular, we engineer robust phase delay defects that take advantage of the ultrabroadband reflection-free sound propagation. Such topological delay lines serve as a paradigm in compact acoustic devices, interconnects, and electroacoustic integrated circuits.

  1. Flux-fusion anomaly test and bosonic topological crystalline insulators

    DOE PAGES

    Hermele, Michael; Chen, Xie

    2016-10-13

    Here, we introduce a method, dubbed the flux-fusion anomaly test, to detect certain anomalous symmetry fractionalization patterns in two-dimensional symmetry-enriched topological (SET) phases. We focus on bosonic systems with Z2 topological order and a symmetry group of the form G=U(1)xG', where G' is an arbitrary group that may include spatial symmetries and/or time reversal. The anomalous fractionalization patterns we identify cannot occur in strictly d=2 systems but can occur at surfaces of d=3 symmetry-protected topological (SPT) phases. This observation leads to examples of d=3 bosonic topological crystalline insulators (TCIs) that, to our knowledge, have not previously been identified. In somemore » cases, these d=3 bosonic TCIs can have an anomalous superfluid at the surface, which is characterized by nontrivial projective transformations of the superfluid vortices under symmetry. The basic idea of our anomaly test is to introduce fluxes of the U(1) symmetry and to show that some fractionalization patterns cannot be extended to a consistent action of G' symmetry on the fluxes. For some anomalies, this can be described in terms of dimensional reduction to d=1 SPT phases. We apply our method to several different symmetry groups with nontrivial anomalies, including G=U(1)×Z T 2 and G=U(1)×Z P 2, where Z T 2 and Z P 2 are time-reversal and d=2 reflection symmetry, respectively.« less

  2. DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases.

    PubMed

    Thomson, Neil H; Santos, Sergio; Mitchenall, Lesley A; Stuchinskaya, Tanya; Taylor, James A; Maxwell, Anthony

    2014-08-21

    DNA topoisomerases control the topology of DNA. Type II topoisomerases exhibit topology simplification, whereby products of their reactions are simplified beyond that expected based on thermodynamic equilibrium. The molecular basis for this process is unknown, although DNA bending has been implicated. To investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of different types (IIA and IIB) were measured using atomic force microscopy (AFM). The enzymes tested were Escherichia coli topo IV and yeast topo II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Sulfolobus shibatae topo VI (type IIB enzymes, which do not). Bend angles were measured using the manual tangent method from topographical AFM images taken with a novel amplitude-modulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given AFM tip size and minimises tip convolution with the sample. This gave improved accuracy and reliability and revealed that all 4 topoisomerases bend DNA by a similar amount: ~120° between the DNA entering and exiting the enzyme complex. These data indicate that DNA bending alone is insufficient to explain topology simplification and that the 'exit gate' may be an important determinant of this process.

  3. DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases

    NASA Astrophysics Data System (ADS)

    Thomson, Neil H.; Santos, Sergio; Mitchenall, Lesley A.; Stuchinskaya, Tanya; Taylor, James A.; Maxwell, Anthony

    2014-08-01

    DNA topoisomerases control the topology of DNA. Type II topoisomerases exhibit topology simplification, whereby products of their reactions are simplified beyond that expected based on thermodynamic equilibrium. The molecular basis for this process is unknown, although DNA bending has been implicated. To investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of different types (IIA and IIB) were measured using atomic force microscopy (AFM). The enzymes tested were Escherichia coli topo IV and yeast topo II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Sulfolobus shibatae topo VI (type IIB enzymes, which do not). Bend angles were measured using the manual tangent method from topographical AFM images taken with a novel amplitude-modulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given AFM tip size and minimises tip convolution with the sample. This gave improved accuracy and reliability and revealed that all 4 topoisomerases bend DNA by a similar amount: ~120° between the DNA entering and exiting the enzyme complex. These data indicate that DNA bending alone is insufficient to explain topology simplification and that the `exit gate' may be an important determinant of this process.

  4. Aberrant topological organization of the functional brain network associated with prior overt hepatic encephalopathy in cirrhotic patients.

    PubMed

    Chen, Hua-Jun; Chen, Qiu-Feng; Yang, Zhe-Ting; Shi, Hai-Bin

    2018-05-30

    A higher risk of cognitive impairments has been found after an overt hepatic encephalopathy (OHE) episode in cirrhotic patients. We investigated the effect of prior OHE episodes on the topological organization of the functional brain network and its association with the relevant cognitive impairments. Resting-state functional MRI data were acquired from 41 cirrhotic patients (19 with prior OHE (Prior-OHE) and 22 without (Non-Prior-OHE)) and 21 healthy controls (HC). A Psychometric Hepatic Encephalopathy Score (PHES) assessed cognition. The whole-brain functional network was constructed by thresholding functional correlation matrices of 90 brain regions (derived from the Automated Anatomic Labeling atlas). The topological properties of the brain network, including small-worldness, network efficiency, and nodal efficiency, were examined using graph theory-based analysis. Globally, the Prior-OHE group had a significantly decreased clustering coefficient and local efficiency, compared with the controls. Locally, the nodal efficiency in the bilateral medial superior frontal gyrus and the right postcentral gyrus decreased in the Prior-OHE group, while the nodal efficiency in the bilateral anterior cingulate/paracingulate gyri and right superior parietal gyrus increased in the Prior-OHE group. The alterations of global and regional network parameters progressed from Non-Prior-OHE to Prior-OHE and the clustering coefficient and local efficiency values were significantly correlated with PHES results. In conclusion, cirrhosis leads to the reduction of brain functional network efficiency, which could be aggravated by a prior OHE episode. Aberrant topological organization of the functional brain network may contribute to a higher risk of cognitive impairments in Prior-OHE patients.

  5. Simple, distance-dependent formulation of the Watts-Strogatz model for directed and undirected small-world networks.

    PubMed

    Song, H Francis; Wang, Xiao-Jing

    2014-12-01

    Small-world networks-complex networks characterized by a combination of high clustering and short path lengths-are widely studied using the paradigmatic model of Watts and Strogatz (WS). Although the WS model is already quite minimal and intuitive, we describe an alternative formulation of the WS model in terms of a distance-dependent probability of connection that further simplifies, both practically and theoretically, the generation of directed and undirected WS-type small-world networks. In addition to highlighting an essential feature of the WS model that has previously been overlooked, namely the equivalence to a simple distance-dependent model, this alternative formulation makes it possible to derive exact expressions for quantities such as the degree and motif distributions and global clustering coefficient for both directed and undirected networks in terms of model parameters.

  6. Simple, distance-dependent formulation of the Watts-Strogatz model for directed and undirected small-world networks

    NASA Astrophysics Data System (ADS)

    Song, H. Francis; Wang, Xiao-Jing

    2014-12-01

    Small-world networks—complex networks characterized by a combination of high clustering and short path lengths—are widely studied using the paradigmatic model of Watts and Strogatz (WS). Although the WS model is already quite minimal and intuitive, we describe an alternative formulation of the WS model in terms of a distance-dependent probability of connection that further simplifies, both practically and theoretically, the generation of directed and undirected WS-type small-world networks. In addition to highlighting an essential feature of the WS model that has previously been overlooked, namely the equivalence to a simple distance-dependent model, this alternative formulation makes it possible to derive exact expressions for quantities such as the degree and motif distributions and global clustering coefficient for both directed and undirected networks in terms of model parameters.

  7. Statistical properties of world investment networks

    NASA Astrophysics Data System (ADS)

    Song, Dong-Ming; Jiang, Zhi-Qiang; Zhou, Wei-Xing

    2009-06-01

    We have performed a detailed investigation on the world investment networks constructed from the Coordinated Portfolio Investment Survey (CPIS) data of the International Monetary Fund, ranging from 2001 to 2006. The distributions of degrees and node strengths are scale-free. The weight distributions can be well modeled by the Weibull distribution. The maximum flow spanning trees of the world investment networks possess two universal allometric scaling relations, independent of time and the investment type. The topological scaling exponent is 1.17±0.02 and the flow scaling exponent is 1.03±0.01.

  8. Scaling behavior of knotted random polygons and self-avoiding polygons: Topological swelling with enhanced exponent.

    PubMed

    Uehara, Erica; Deguchi, Tetsuo

    2017-12-07

    We show that the average size of self-avoiding polygons (SAPs) with a fixed knot is much larger than that of no topological constraint if the excluded volume is small and the number of segments is large. We call it topological swelling. We argue an "enhancement" of the scaling exponent for random polygons with a fixed knot. We study them systematically through SAP consisting of hard cylindrical segments with various different values of the radius of segments. Here we mean by the average size the mean-square radius of gyration. Furthermore, we show numerically that the topological balance length of a composite knot is given by the sum of those of all constituent prime knots. Here we define the topological balance length of a knot by such a number of segments that topological entropic repulsions are balanced with the knot complexity in the average size. The additivity suggests the local knot picture.

  9. Scaling behavior of knotted random polygons and self-avoiding polygons: Topological swelling with enhanced exponent

    NASA Astrophysics Data System (ADS)

    Uehara, Erica; Deguchi, Tetsuo

    2017-12-01

    We show that the average size of self-avoiding polygons (SAPs) with a fixed knot is much larger than that of no topological constraint if the excluded volume is small and the number of segments is large. We call it topological swelling. We argue an "enhancement" of the scaling exponent for random polygons with a fixed knot. We study them systematically through SAP consisting of hard cylindrical segments with various different values of the radius of segments. Here we mean by the average size the mean-square radius of gyration. Furthermore, we show numerically that the topological balance length of a composite knot is given by the sum of those of all constituent prime knots. Here we define the topological balance length of a knot by such a number of segments that topological entropic repulsions are balanced with the knot complexity in the average size. The additivity suggests the local knot picture.

  10. Local and global synchronization transitions induced by time delays in small-world neuronal networks with chemical synapses.

    PubMed

    Yu, Haitao; Wang, Jiang; Du, Jiwei; Deng, Bin; Wei, Xile

    2015-02-01

    Effects of time delay on the local and global synchronization in small-world neuronal networks with chemical synapses are investigated in this paper. Numerical results show that, for both excitatory and inhibitory coupling types, the information transmission delay can always induce synchronization transitions of spiking neurons in small-world networks. In particular, regions of in-phase and out-of-phase synchronization of connected neurons emerge intermittently as the synaptic delay increases. For excitatory coupling, all transitions to spiking synchronization occur approximately at integer multiples of the firing period of individual neurons; while for inhibitory coupling, these transitions appear at the odd multiples of the half of the firing period of neurons. More importantly, the local synchronization transition is more profound than the global synchronization transition, depending on the type of coupling synapse. For excitatory synapses, the local in-phase synchronization observed for some values of the delay also occur at a global scale; while for inhibitory ones, this synchronization, observed at the local scale, disappears at a global scale. Furthermore, the small-world structure can also affect the phase synchronization of neuronal networks. It is demonstrated that increasing the rewiring probability can always improve the global synchronization of neuronal activity, but has little effect on the local synchronization of neighboring neurons.

  11. It's a small world after all: contrasting hierarchical and edge networks in a simulated intelligence analysis task.

    PubMed

    Stanton, Neville A; Walker, Guy H; Sorensen, Linda J

    2012-01-01

    This article presents the rationale behind an important enhancement to a socio-technical model of organisations and teams derived from military research. It combines this with empirical results which take advantage of these enhancements. In Part 1, a new theoretical legacy for the model is developed based on Ergonomics theories and insights. This allows team communications data to be plotted into the model and for it to demonstrate discriminate validity between alternative team structures. Part 2 presents multinational data from the Experimental Laboratory for Investigating Collaboration, Information-sharing, and Trust (ELICIT) community. It was surprising to see that teams in both traditional hierarchical command and control and networked 'peer-to-peer' organisations operate in broadly the same area of the model, a region occupied by networks of communication exhibiting 'small world' properties. Small world networks may be of considerable importance for the Ergonomics analysis of team organisation and performance. This article is themed around macro and systems Ergonomics, and examines the effects of command and control structures. Despite some differences in behaviour and measures of agility, when given the freedom to do so, participants organised themselves into a small world network. This network type has important and interesting implications for the Ergonomics design of teams and organisations.

  12. Biased and unbiased strategies to identify biologically active small molecules.

    PubMed

    Abet, Valentina; Mariani, Angelica; Truscott, Fiona R; Britton, Sébastien; Rodriguez, Raphaël

    2014-08-15

    Small molecules are central players in chemical biology studies. They promote the perturbation of cellular processes underlying diseases and enable the identification of biological targets that can be validated for therapeutic intervention. Small molecules have been shown to accurately tune a single function of pluripotent proteins in a reversible manner with exceptional temporal resolution. The identification of molecular probes and drugs remains a worthy challenge that can be addressed by the use of biased and unbiased strategies. Hypothesis-driven methodologies employs a known biological target to synthesize complementary hits while discovery-driven strategies offer the additional means of identifying previously unanticipated biological targets. This review article provides a general overview of recent synthetic frameworks that gave rise to an impressive arsenal of biologically active small molecules with unprecedented cellular mechanisms. Copyright © 2014. Published by Elsevier Ltd.

  13. Graph theory data for topological quantum chemistry.

    PubMed

    Vergniory, M G; Elcoro, L; Wang, Zhijun; Cano, Jennifer; Felser, C; Aroyo, M I; Bernevig, B Andrei; Bradlyn, Barry

    2017-08-01

    Topological phases of noninteracting particles are distinguished by the global properties of their band structure and eigenfunctions in momentum space. On the other hand, group theory as conventionally applied to solid-state physics focuses only on properties that are local (at high-symmetry points, lines, and planes) in the Brillouin zone. To bridge this gap, we have previously [Bradlyn et al., Nature (London) 547, 298 (2017)NATUAS0028-083610.1038/nature23268] mapped the problem of constructing global band structures out of local data to a graph construction problem. In this paper, we provide the explicit data and formulate the necessary algorithms to produce all topologically distinct graphs. Furthermore, we show how to apply these algorithms to certain "elementary" band structures highlighted in the aforementioned reference, and thus we identified and tabulated all orbital types and lattices that can give rise to topologically disconnected band structures. Finally, we show how to use the newly developed bandrep program on the Bilbao Crystallographic Server to access the results of our computation.

  14. Topological surface states in nodal superconductors.

    PubMed

    Schnyder, Andreas P; Brydon, Philip M R

    2015-06-24

    Topological superconductors have become a subject of intense research due to their potential use for technical applications in device fabrication and quantum information. Besides fully gapped superconductors, unconventional superconductors with point or line nodes in their order parameter can also exhibit nontrivial topological characteristics. This article reviews recent progress in the theoretical understanding of nodal topological superconductors, with a focus on Weyl and noncentrosymmetric superconductors and their protected surface states. Using selected examples, we review the bulk topological properties of these systems, study different types of topological surface states, and examine their unusual properties. Furthermore, we survey some candidate materials for topological superconductivity and discuss different experimental signatures of topological surface states.

  15. Considerations for Multiprocessor Topologies

    NASA Technical Reports Server (NTRS)

    Byrd, Gregory T.; Delagi, Bruce A.

    1987-01-01

    Choosing a multiprocessor interconnection topology may depend on high-level considerations, such as the intended application domain and the expected number of processors. It certainly depends on low-level implementation details, such as packaging and communications protocols. The authors first use rough measures of cost and performance to characterize several topologies. They then examine how implementation details can affect the realizable performance of a topology.

  16. Duality and topology

    NASA Astrophysics Data System (ADS)

    Sacramento, P. D.; Vieira, V. R.

    2018-04-01

    Mappings between models may be obtained by unitary transformations with preservation of the spectra but in general a change in the states. Non-canonical transformations in general also change the statistics of the operators involved. In these cases one may expect a change of topological properties as a consequence of the mapping. Here we consider some dualities resulting from mappings, by systematically using a Majorana fermion representation of spin and fermionic problems. We focus on the change of topological invariants that results from unitary transformations taking as examples the mapping between a spin system and a topological superconductor, and between different fermionic systems.

  17. Topological Sachdev-Ye-Kitaev model

    NASA Astrophysics Data System (ADS)

    Zhang, Pengfei; Zhai, Hui

    2018-05-01

    In this Rapid Communication, we construct a large-N exactly solvable model to study the interplay between interaction and topology, by connecting the Sachdev-Ye-Kitaev (SYK) model with constant hopping. The hopping forms a band structure that can exhibit both topologically trivial and nontrivial phases. Starting from a topologically trivial insulator with zero Hall conductance, we show that the interaction can drive a phase transition to a topologically nontrivial insulator with quantized nonzero Hall conductance, and a single gapless Dirac fermion emerges when the interaction is fine tuned to the critical point. The finite temperature effect is also considered, and we show that the topological phase with a stronger interaction is less stable against temperature. Our model provides a concrete example to illustrate the interacting topological phases and phase transitions, and can shed light on similar problems in physical systems.

  18. Nobel Lecture: Topological quantum matter*

    NASA Astrophysics Data System (ADS)

    Haldane, F. Duncan M.

    2017-10-01

    Nobel Lecture, presented December 8, 2016, Aula Magna, Stockholm University. I will describe the history and background of three discoveries cited in this Nobel Prize: The "TKNN" topological formula for the integer quantum Hall effect found by David Thouless and collaborators, the Chern insulator or quantum anomalous Hall effect, and its role in the later discovery of time-reversal-invariant topological insulators, and the unexpected topological spin-liquid state of the spin-1 quantum antiferromagnetic chain, which provided an initial example of topological quantum matter. I will summarize how these early beginnings have led to the exciting, and currently extremely active, field of "topological matter."

  19. Topology optimized permanent magnet systems

    NASA Astrophysics Data System (ADS)

    Bjørk, R.; Bahl, C. R. H.; Insinga, A. R.

    2017-09-01

    Topology optimization of permanent magnet systems consisting of permanent magnets, high permeability iron and air is presented. An implementation of topology optimization for magnetostatics is discussed and three examples are considered. The Halbach cylinder is topology optimized with iron and an increase of 15% in magnetic efficiency is shown. A topology optimized structure to concentrate a homogeneous field is shown to increase the magnitude of the field by 111%. Finally, a permanent magnet with alternating high and low field regions is topology optimized and a Λcool figure of merit of 0.472 is reached, which is an increase of 100% compared to a previous optimized design.

  20. Renormalization group approach to symmetry protected topological phases

    NASA Astrophysics Data System (ADS)

    van Nieuwenburg, Evert P. L.; Schnyder, Andreas P.; Chen, Wei

    2018-04-01

    A defining feature of a symmetry protected topological phase (SPT) in one dimension is the degeneracy of the Schmidt values for any given bipartition. For the system to go through a topological phase transition separating two SPTs, the Schmidt values must either split or cross at the critical point in order to change their degeneracies. A renormalization group (RG) approach based on this splitting or crossing is proposed, through which we obtain an RG flow that identifies the topological phase transitions in the parameter space. Our approach can be implemented numerically in an efficient manner, for example, using the matrix product state formalism, since only the largest first few Schmidt values need to be calculated with sufficient accuracy. Using several concrete models, we demonstrate that the critical points and fixed points of the RG flow coincide with the maxima and minima of the entanglement entropy, respectively, and the method can serve as a numerically efficient tool to analyze interacting SPTs in the parameter space.

  1. Topology-energy relationships and lowest energy configurations for pentagonal dodecahedral (H2O)20X clusters, X=empty, H2O, NH3, H3O+: The importance of O-topology

    NASA Astrophysics Data System (ADS)

    Anick, David J.

    2010-04-01

    For (H2O)20X water clusters consisting of X enclosed by the 512 dodecahedral cage, X=empty, H2O, NH3, and H3O+, databases are made consisting of 55-82 isomers optimized via B3LYP/6-311++G∗∗. Correlations are explored between ground state electronic energy (Ee) or electronic energy plus zero point energy (Ee+ZPE) and the clusters' topology, defined as the set of directed H-bonds. Linear regression is done to identify topological features that correlate with cluster energy. For each X, variables are found that account for 99% of the variance in Ee and predict it with a rms error under 0.2 kcal/mol. The method of analysis emphasizes the importance of an intermediate level of structure, the "O-topology," consisting of O-types and a list of O pairs that are bonded but omitting H-bond directions, as a device to organize the databases and reduce the number of structures one needs to consider. Relevant variables include three parameters, which count the number of H-bonds having particular donor and acceptor types; |M|2, where M is the cluster's vector dipole moment; and the projection of M onto the symmetry axis of X. Scatter diagrams for Ee or Ee+ZPE versus |M| show that clusters fall naturally into "families" defined by the values of certain discrete parameters, the "major parameters," for each X. Combining "family" analysis and O-topologies, a small group of clusters is identified for each X that are candidates to be the global minimum, and the minimum is determined. For X=H3O+, one cluster with central hydronium lies just 2.08 kcal/mol above the lowest isomer with surface hydronium. Implications of the methodology for dodecahedral (H2O)20(NH4+) and (H2O)20(NH4+)(OH-) are discussed, and new lower energy isomers are found. For MP2/TZVP, the lowest-energy (H2O)20(NH4+) isomer features a trifurcated H-bond. The results suggest a much more efficient and comprehensive way of seeking low-energy water cluster geometries that may have wide applicability.

  2. Topology-energy relationships and lowest energy configurations for pentagonal dodecahedral (H2O)20X clusters, X = empty, H2O, NH3, H3O+: the importance of O-topology.

    PubMed

    Anick, David J

    2010-04-28

    For (H(2)O)(20)X water clusters consisting of X enclosed by the 5(12) dodecahedral cage, X = empty, H(2)O, NH(3), and H(3)O(+), databases are made consisting of 55-82 isomers optimized via B3LYP/6-311++G(**). Correlations are explored between ground state electronic energy (Ee) or electronic energy plus zero point energy (Ee+ZPE) and the clusters' topology, defined as the set of directed H-bonds. Linear regression is done to identify topological features that correlate with cluster energy. For each X, variables are found that account for 99% of the variance in Ee and predict it with a rms error under 0.2 kcal/mol. The method of analysis emphasizes the importance of an intermediate level of structure, the "O-topology," consisting of O-types and a list of O pairs that are bonded but omitting H-bond directions, as a device to organize the databases and reduce the number of structures one needs to consider. Relevant variables include three parameters, which count the number of H-bonds having particular donor and acceptor types; absolute value(M)(2), where M is the cluster's vector dipole moment; and the projection of M onto the symmetry axis of X. Scatter diagrams for Ee or Ee+ZPE versus absolute value(M) show that clusters fall naturally into "families" defined by the values of certain discrete parameters, the "major parameters," for each X. Combining "family" analysis and O-topologies, a small group of clusters is identified for each X that are candidates to be the global minimum, and the minimum is determined. For X = H(3)O(+), one cluster with central hydronium lies just 2.08 kcal/mol above the lowest isomer with surface hydronium. Implications of the methodology for dodecahedral (H(2)O)(20)(NH(4)(+)) and (H(2)O)(20)(NH(4)(+))(OH(-)) are discussed, and new lower energy isomers are found. For MP2/TZVP, the lowest-energy (H(2)O)(20)(NH(4)(+)) isomer features a trifurcated H-bond. The results suggest a much more efficient and comprehensive way of seeking low

  3. Autoassociative memory retrieval and spontaneous activity bumps in small-world networks of integrate-and-fire neurons.

    PubMed

    Anishchenko, Anastasia; Treves, Alessandro

    2006-10-01

    The metric structure of synaptic connections is obviously an important factor in shaping the properties of neural networks, in particular the capacity to retrieve memories, with which are endowed autoassociative nets operating via attractor dynamics. Qualitatively, some real networks in the brain could be characterized as 'small worlds', in the sense that the structure of their connections is intermediate between the extremes of an orderly geometric arrangement and of a geometry-independent random mesh. Small worlds can be defined more precisely in terms of their mean path length and clustering coefficient; but is such a precise description useful for a better understanding of how the type of connectivity affects memory retrieval? We have simulated an autoassociative memory network of integrate-and-fire units, positioned on a ring, with the network connectivity varied parametrically between ordered and random. We find that the network retrieves previously stored memory patterns when the connectivity is close to random, and displays the characteristic behavior of ordered nets (localized 'bumps' of activity) when the connectivity is close to ordered. Recent analytical work shows that these two behaviors can coexist in a network of simple threshold-linear units, leading to localized retrieval states. We find that they tend to be mutually exclusive behaviors, however, with our integrate-and-fire units. Moreover, the transition between the two occurs for values of the connectivity parameter which are not simply related to the notion of small worlds.

  4. Emergence of rich-club topology and coordinated dynamics in development of hippocampal functional networks in vitro.

    PubMed

    Schroeter, Manuel S; Charlesworth, Paul; Kitzbichler, Manfred G; Paulsen, Ole; Bullmore, Edward T

    2015-04-08

    Recent studies demonstrated that the anatomical network of the human brain shows a "rich-club" organization. This complex topological feature implies that highly connected regions, hubs of the large-scale brain network, are more densely interconnected with each other than expected by chance. Rich-club nodes were traversed by a majority of short paths between peripheral regions, underlining their potential importance for efficient global exchange of information between functionally specialized areas of the brain. Network hubs have also been described at the microscale of brain connectivity (so-called "hub neurons"). Their role in shaping synchronous dynamics and forming microcircuit wiring during development, however, is not yet fully understood. The present study aimed to investigate the role of hubs during network development, using multi-electrode arrays and functional connectivity analysis during spontaneous multi-unit activity (MUA) of dissociated primary mouse hippocampal neurons. Over the first 4 weeks in vitro, functional connectivity significantly increased in strength, density, and size, with mature networks demonstrating a robust modular and small-world topology. As expected by a "rich-get-richer" growth rule of network evolution, MUA graphs were found to form rich-clubs at an early stage in development (14 DIV). Later on, rich-club nodes were a consistent topological feature of MUA graphs, demonstrating high nodal strength, efficiency, and centrality. Rich-club nodes were also found to be crucial for MUA dynamics. They often served as broker of spontaneous activity flow, confirming that hub nodes and rich-clubs may play an important role in coordinating functional dynamics at the microcircuit level. Copyright © 2015 the authors 0270-6474/15/355459-12$15.00/0.

  5. Asymmetry of Hemispheric Network Topology Reveals Dissociable Processes between Functional and Structural Brain Connectome in Community-Living Elders

    PubMed Central

    Sun, Yu; Li, Junhua; Suckling, John; Feng, Lei

    2017-01-01

    Human brain is structurally and functionally asymmetrical and the asymmetries of brain phenotypes have been shown to change in normal aging. Recent advances in graph theoretical analysis have showed topological lateralization between hemispheric networks in the human brain throughout the lifespan. Nevertheless, apparent discrepancies of hemispheric asymmetry were reported between the structural and functional brain networks, indicating the potentially complex asymmetry patterns between structural and functional networks in aging population. In this study, using multimodal neuroimaging (resting-state fMRI and structural diffusion tensor imaging), we investigated the characteristics of hemispheric network topology in 76 (male/female = 15/61, age = 70.08 ± 5.30 years) community-dwelling older adults. Hemispheric functional and structural brain networks were obtained for each participant. Graph theoretical approaches were then employed to estimate the hemispheric topological properties. We found that the optimal small-world properties were preserved in both structural and functional hemispheric networks in older adults. Moreover, a leftward asymmetry in both global and local levels were observed in structural brain networks in comparison with a symmetric pattern in functional brain network, suggesting a dissociable process of hemispheric asymmetry between structural and functional connectome in healthy older adults. Finally, the scores of hemispheric asymmetry in both structural and functional networks were associated with behavioral performance in various cognitive domains. Taken together, these findings provide new insights into the lateralized nature of multimodal brain connectivity, highlight the potentially complex relationship between structural and functional brain network alterations, and augment our understanding of asymmetric structural and functional specializations in normal aging. PMID:29209197

  6. Concept Model on Topological Learning

    NASA Astrophysics Data System (ADS)

    Ae, Tadashi; Kioi, Kazumasa

    2010-11-01

    We discuss a new model for concept based on topological learning, where the learning process on the neural network is represented by mathematical topology. The topological learning of neural networks is summarized by a quotient of input space and the hierarchical step induces a tree where each node corresponds to a quotient. In general, the concept acquisition is a difficult problem, but the emotion for a subject is represented by providing the questions to a person. Therefore, a kind of concept is captured by such data and the answer sheet can be mapped into a topology consisting of trees. In this paper, we will discuss a way of mapping the emotional concept to a topological learning model.

  7. How to obtain a cosmological constant from small exotic R4

    NASA Astrophysics Data System (ADS)

    Asselmeyer-Maluga, Torsten; Król, Jerzy

    2018-03-01

    In this paper we determine the cosmological constant as a topological invariant by applying certain techniques from low dimensional differential topology. We work with a small exotic R4 which is embedded into the standard R4. Any exotic R4 is a Riemannian smooth manifold with necessary non-vanishing curvature tensor. To determine the invariant part of such curvature we deal with a canonical construction of R4 where it appears as a part of the complex surface K 3 # CP(2) bar. Such R4's admit hyperbolic geometry. This fact simplifies significantly the calculations and enforces the rigidity of the expressions. In particular, we explain the smallness of the cosmological constant with a value consisting of a combination of (natural) topological invariant. Finally, the cosmological constant appears to be a topologically supported quantity.

  8. Simulating a topological transition in a superconducting phase qubit by fast adiabatic trajectories

    NASA Astrophysics Data System (ADS)

    Wang, Tenghui; Zhang, Zhenxing; Xiang, Liang; Gong, Zhihao; Wu, Jianlan; Yin, Yi

    2018-04-01

    The significance of topological phases has been widely recognized in the community of condensed matter physics. The well controllable quantum systems provide an artificial platform to probe and engineer various topological phases. The adiabatic trajectory of a quantum state describes the change of the bulk Bloch eigenstates with the momentum, and this adiabatic simulation method is however practically limited due to quantum dissipation. Here we apply the "shortcut to adiabaticity" (STA) protocol to realize fast adiabatic evolutions in the system of a superconducting phase qubit. The resulting fast adiabatic trajectories illustrate the change of the bulk Bloch eigenstates in the Su-Schrieffer-Heeger (SSH) model. A sharp transition is experimentally determined for the topological invariant of a winding number. Our experiment helps identify the topological Chern number of a two-dimensional toy model, suggesting the applicability of the fast adiabatic simulation method for topological systems.

  9. Magnification of signatures of a topological phase transition by quantum zero point motion

    NASA Astrophysics Data System (ADS)

    Lopes, Pedro L. e. S.; Ghaemi, Pouyan

    2015-08-01

    We show that the zero point motion of a vortex in superconducting doped topological insulators leads to significant changes in the electronic spectrum at the topological phase transition in this system. This topological phase transition is tuned by the doping level, and the corresponding effects are manifest in the density of states at energies which are on the order of the vortex fluctuation frequency. Although the electronic energy gap in the spectrum generated by a stationary vortex is but a small fraction of the bulk superconducting gap, the vortex fluctuation frequency may be much larger. As a result, this quantum zero point motion can induce a discontinuous change in the spectral features of the system at the topological vortex phase transition to energies which are well within the resolution of scanning tunneling microscopy. This discontinuous change is exclusive to superconducting systems in which we have a topological phase transition. Moreover, the phenomena studied in this paper present effects of Magnus forces on the vortex spectrum which are not present in the ordinary s -wave superconductors. Finally, we demonstrate explicitly that the vortex in this system is equivalent to a Kitaev chain. This allows for the mapping of the vortex fluctuating scenario in three dimensions into similar one-dimensional situations in which one may search for other novel signatures of topological phase transitions.

  10. Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma

    PubMed Central

    Gao, She-Gan; Liu, Rui-Min; Zhao, Yun-Gang; Wang, Pei; Ward, Douglas G.; Wang, Guang-Chao; Guo, Xiang-Qian; Gu, Juan; Niu, Wan-Bin; Zhang, Tian; Martin, Ashley; Guo, Zhi-Peng; Feng, Xiao-Shan; Qi, Yi-Jun; Ma, Yuan-Fang

    2016-01-01

    Combining MS-based proteomic data with network and topological features of such network would identify more clinically relevant molecules and meaningfully expand the repertoire of proteins derived from MS analysis. The integrative topological indexes representing 95.96% information of seven individual topological measures of node proteins were calculated within a protein-protein interaction (PPI) network, built using 244 differentially expressed proteins (DEPs) identified by iTRAQ 2D-LC-MS/MS. Compared with DEPs, differentially expressed genes (DEGs) and comprehensive features (CFs), structurally dominant nodes (SDNs) based on integrative topological index distribution produced comparable classification performance in three different clinical settings using five independent gene expression data sets. The signature molecules of SDN-based classifier for distinction of early from late clinical TNM stages were enriched in biological traits of protein synthesis, intracellular localization and ribosome biogenesis, which suggests that ribosome biogenesis represents a promising therapeutic target for treating ESCC. In addition, ITGB1 expression selected exclusively by integrative topological measures correlated with clinical stages and prognosis, which was further validated with two independent cohorts of ESCC samples. Thus the integrative topological analysis of PPI networks proposed in this study provides an alternative approach to identify potential biomarkers and therapeutic targets from MS/MS data with functional insights in ESCC. PMID:26898710

  11. Observation of topological nodal fermion semimetal phase in ZrSiS

    DOE PAGES

    Neupane, Madhab; Belopolski, Ilya; Hosen, M. Mofazzel; ...

    2016-05-11

    We present that unveiling new topological phases of matter is one of the current objectives in condensed matter physics. Recent experimental discoveries of Dirac and Weyl semimetals prompt the search for other exotic phases of matter. Here we present a systematic angle-resolved photoemission spectroscopy study of ZrSiS, a prime topological nodal semimetal candidate. Our wider Brillouin zone (BZ) mapping shows multiple Fermi surface pockets such as the diamond-shaped Fermi surface, elliptical-shaped Fermi surface, and a small electron pocket encircling at the zone center (Γ) point, the M point, and the X point of the BZ, respectively. We experimentally establish themore » spinless nodal fermion semimetal phase in ZrSiS, which is supported by our first-principles calculations. Our findings evidence that the ZrSiS-type of material family is a new platform on which to explore exotic states of quantum matter; these materials are expected to provide an avenue for engineering two-dimensional topological insulator systems.« less

  12. Two-dimensional topological photonics

    NASA Astrophysics Data System (ADS)

    Khanikaev, Alexander B.; Shvets, Gennady

    2017-12-01

    Originating from the studies of two-dimensional condensed-matter states, the concept of topological order has recently been expanded to other fields of physics and engineering, particularly optics and photonics. Topological photonic structures have already overturned some of the traditional views on wave propagation and manipulation. The application of topological concepts to guided wave propagation has enabled novel photonic devices, such as reflection-free sharply bent waveguides, robust delay lines, spin-polarized switches and non-reciprocal devices. Discrete degrees of freedom, widely used in condensed-matter physics, such as spin and valley, are now entering the realm of photonics. In this Review, we summarize the latest advances in this highly dynamic field, with special emphasis on the experimental work on two-dimensional photonic topological structures.

  13. Topological quantum distillation.

    PubMed

    Bombin, H; Martin-Delgado, M A

    2006-11-03

    We construct a class of topological quantum codes to perform quantum entanglement distillation. These codes implement the whole Clifford group of unitary operations in a fully topological manner and without selective addressing of qubits. This allows us to extend their application also to quantum teleportation, dense coding, and computation with magic states.

  14. Chiral topological insulator of magnons

    NASA Astrophysics Data System (ADS)

    Li, Bo; Kovalev, Alexey A.

    2018-05-01

    We propose a magnon realization of 3D topological insulator in the AIII (chiral symmetry) topological class. The topological magnon gap opens due to the presence of Dzyaloshinskii-Moriya interactions. The existence of the topological invariant is established by calculating the bulk winding number of the system. Within our model, the surface magnon Dirac cone is protected by the sublattice chiral symmetry. By analyzing the magnon surface modes, we confirm that the backscattering is prohibited. By weakly breaking the chiral symmetry, we observe the magnon Hall response on the surface due to opening of the gap. Finally, we show that by changing certain parameters, the system can be tuned between the chiral topological insulator, three-dimensional magnon anomalous Hall, and Weyl magnon phases.

  15. Robust superconductivity with nodes in the superconducting topological insulator CuxBi2Se3 : Zeeman orbital field and nonmagnetic impurities

    NASA Astrophysics Data System (ADS)

    Nagai, Yuki

    2015-02-01

    We study the robustness against nonmagnetic impurities in the topological superconductor with point nodes, focusing on an effective model of CuxBi2Se3 . We find that the topological superconductivity with point nodes is not fragile against nonmagnetic impurities, although the superconductivity with nodes in past studies is usually fragile. Exchanging the role of spin with the one of orbital, and vice versa, we find that in the "dual" space the topological superconductor with point nodes is regarded as the intraorbital spin-singlet s -wave one. From the viewpoint of the dual space, we deduce that the point-node state is not fragile against nonmagnetic impurity, when the orbital imbalance in the normal states is small. Since the spin imbalance is induced by the Zeeman magnetic field, we shall name this key quantity for the impurity effects the Zeeman "orbital" field. The numerical calculations support that the deduction is correct. If the Zeeman orbital field is small, the topological superconductivity is not fragile in dirty materials, even with nodes. Thus, the topological superconductors cannot be simply regarded as one of the conventional unconventional superconductors.

  16. Comparative study on gene set and pathway topology-based enrichment methods.

    PubMed

    Bayerlová, Michaela; Jung, Klaus; Kramer, Frank; Klemm, Florian; Bleckmann, Annalen; Beißbarth, Tim

    2015-10-22

    Enrichment analysis is a popular approach to identify pathways or sets of genes which are significantly enriched in the context of differentially expressed genes. The traditional gene set enrichment approach considers a pathway as a simple gene list disregarding any knowledge of gene or protein interactions. In contrast, the new group of so called pathway topology-based methods integrates the topological structure of a pathway into the analysis. We comparatively investigated gene set and pathway topology-based enrichment approaches, considering three gene set and four topological methods. These methods were compared in two extensive simulation studies and on a benchmark of 36 real datasets, providing the same pathway input data for all methods. In the benchmark data analysis both types of methods showed a comparable ability to detect enriched pathways. The first simulation study was conducted with KEGG pathways, which showed considerable gene overlaps between each other. In this study with original KEGG pathways, none of the topology-based methods outperformed the gene set approach. Therefore, a second simulation study was performed on non-overlapping pathways created by unique gene IDs. Here, methods accounting for pathway topology reached higher accuracy than the gene set methods, however their sensitivity was lower. We conducted one of the first comprehensive comparative works on evaluating gene set against pathway topology-based enrichment methods. The topological methods showed better performance in the simulation scenarios with non-overlapping pathways, however, they were not conclusively better in the other scenarios. This suggests that simple gene set approach might be sufficient to detect an enriched pathway under realistic circumstances. Nevertheless, more extensive studies and further benchmark data are needed to systematically evaluate these methods and to assess what gain and cost pathway topology information introduces into enrichment analysis. Both

  17. Disrupted Topological Patterns of Large-Scale Network in Conduct Disorder

    PubMed Central

    Jiang, Yali; Liu, Weixiang; Ming, Qingsen; Gao, Yidian; Ma, Ren; Zhang, Xiaocui; Situ, Weijun; Wang, Xiang; Yao, Shuqiao; Huang, Bingsheng

    2016-01-01

    Regional abnormalities in brain structure and function, as well as disrupted connectivity, have been found repeatedly in adolescents with conduct disorder (CD). Yet, the large-scale brain topology associated with CD is not well characterized, and little is known about the systematic neural mechanisms of CD. We employed graphic theory to investigate systematically the structural connectivity derived from cortical thickness correlation in a group of patients with CD (N = 43) and healthy controls (HCs, N = 73). Nonparametric permutation tests were applied for between-group comparisons of graphical metrics. Compared with HCs, network measures including global/local efficiency and modularity all pointed to hypo-functioning in CD, despite of preserved small-world organization in both groups. The hubs distribution is only partially overlapped with each other. These results indicate that CD is accompanied by both impaired integration and segregation patterns of brain networks, and the distribution of highly connected neural network ‘hubs’ is also distinct between groups. Such misconfiguration extends our understanding regarding how structural neural network disruptions may underlie behavioral disturbances in adolescents with CD, and potentially, implicates an aberrant cytoarchitectonic profiles in the brain of CD patients. PMID:27841320

  18. The Effect of Angle Restriction on the Topological Characteristics of Minicircle Networks

    NASA Astrophysics Data System (ADS)

    Arsuaga, J.; Diao, Y.; Hinson, K.

    2012-01-01

    Networks of topologically linked minicircle polymers are found in diverse natural systems and are a subject of intense research in nanotechonology. In a recent report the authors introduced a new theoretical model to study the effects of polymer density on the formation and on the topological properties of minicircle networks. Three key topological characteristics were identified in the formation and characterization of a network: the critical percolation density, the average saturation density and the mean valence of the network. In this work we report how these characteristics change when an orientation bias is imposed on the minicircles forming the network. We observe that such restrictions have significant effects on the key topological characteristics of the network. In particular while the effects of restriction of the tilting angle can be predicted we find that those of the azimuthal angle can have somewhat unexpected results.

  19. Optimal convergence in naming game with geography-based negotiation on small-world networks

    NASA Astrophysics Data System (ADS)

    Liu, Run-Ran; Wang, Wen-Xu; Lai, Ying-Cheng; Chen, Guanrong; Wang, Bing-Hong

    2011-01-01

    We propose a negotiation strategy to address the effect of geography on the dynamics of naming games over small-world networks. Communication and negotiation frequencies between two agents are determined by their geographical distance in terms of a parameter characterizing the correlation between interaction strength and the distance. A finding is that there exists an optimal parameter value leading to fastest convergence to global consensus on naming. Numerical computations and a theoretical analysis are provided to substantiate our findings.

  20. Two-dimensional topological photonic systems

    NASA Astrophysics Data System (ADS)

    Sun, Xiao-Chen; He, Cheng; Liu, Xiao-Ping; Lu, Ming-Hui; Zhu, Shi-Ning; Chen, Yan-Feng

    2017-09-01

    The topological phase of matter, originally proposed and first demonstrated in fermionic electronic systems, has drawn considerable research attention in the past decades due to its robust transport of edge states and its potential with respect to future quantum information, communication, and computation. Recently, searching for such a unique material phase in bosonic systems has become a hot research topic worldwide. So far, many bosonic topological models and methods for realizing them have been discovered in photonic systems, acoustic systems, mechanical systems, etc. These discoveries have certainly yielded vast opportunities in designing material phases and related properties in the topological domain. In this review, we first focus on some of the representative photonic topological models and employ the underlying Dirac model to analyze the edge states and geometric phase. On the basis of these models, three common types of two-dimensional topological photonic systems are discussed: 1) photonic quantum Hall effect with broken time-reversal symmetry; 2) photonic topological insulator and the associated pseudo-time-reversal symmetry-protected mechanism; 3) time/space periodically modulated photonic Floquet topological insulator. Finally, we provide a summary and extension of this emerging field, including a brief introduction to the Weyl point in three-dimensional systems.

  1. Interactive Spacecraft Trajectory Design Strategies Featuring Poincare Map Topology

    NASA Astrophysics Data System (ADS)

    Schlei, Wayne R.

    Space exploration efforts are shifting towards inexpensive and more agile vehicles. Versatility regarding spacecraft trajectories refers to the agility to correct deviations from an intended path or even the ability to adapt the future path to a new destination--all with limited spaceflight resources (i.e., small DeltaV budgets). Trajectory design methods for such nimble vehicles incorporate equally versatile procedures that allow for rapid and interactive decision making while attempting to reduce Delta V budgets, leading to a versatile trajectory design platform. A versatile design paradigm requires the exploitation of Poincare map topology , or the interconnected web of dynamical structures, existing within the chaotic dynamics of multi-body gravitational models to outline low-Delta V transfer options residing nearby to a current path. This investigation details an autonomous procedure to extract the periodic orbits (topology nodes) and correlated asymptotic flow structures (or the invariant manifolds representing topology links). The autonomous process summarized in this investigation (termed PMATE) overcomes discontinuities on the Poincare section that arise in the applied multi-body model (the planar circular restricted three-body problem) and detects a wide variety of novel periodic orbits. New interactive capabilities deliver a visual analytics foundation for versatile spaceflight design, especially for initial guess generation and manipulation. Such interactive strategies include the selection of states and arcs from Poincare section visualizations and the capabilities to draw and drag trajectories to remove dependency on initial state input. Furthermore, immersive selection is expanded to cull invariant manifold structures, yielding low-DeltaV or even DeltaV-free transfers between periodic orbits. The application of interactive design strategies featuring a dense extraction of Poincare map topology is demonstrated for agile spaceflight with a simple

  2. Topology of Document Retrieval Systems.

    ERIC Educational Resources Information Center

    Everett, Daniel M.; Cater, Steven C.

    1992-01-01

    Explains the use of a topological structure to examine the closeness between documents in retrieval systems and analyzes the topological structure of a vector-space model, a fuzzy-set model, an extended Boolean model, a probabilistic model, and a TIRS (Topological Information Retrieval System) model. Proofs for the results are appended. (17…

  3. Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival.

    PubMed

    Nicolau, Monica; Levine, Arnold J; Carlsson, Gunnar

    2011-04-26

    High-throughput biological data, whether generated as sequencing, transcriptional microarrays, proteomic, or other means, continues to require analytic methods that address its high dimensional aspects. Because the computational part of data analysis ultimately identifies shape characteristics in the organization of data sets, the mathematics of shape recognition in high dimensions continues to be a crucial part of data analysis. This article introduces a method that extracts information from high-throughput microarray data and, by using topology, provides greater depth of information than current analytic techniques. The method, termed Progression Analysis of Disease (PAD), first identifies robust aspects of cluster analysis, then goes deeper to find a multitude of biologically meaningful shape characteristics in these data. Additionally, because PAD incorporates a visualization tool, it provides a simple picture or graph that can be used to further explore these data. Although PAD can be applied to a wide range of high-throughput data types, it is used here as an example to analyze breast cancer transcriptional data. This identified a unique subgroup of Estrogen Receptor-positive (ER(+)) breast cancers that express high levels of c-MYB and low levels of innate inflammatory genes. These patients exhibit 100% survival and no metastasis. No supervised step beyond distinction between tumor and healthy patients was used to identify this subtype. The group has a clear and distinct, statistically significant molecular signature, it highlights coherent biology but is invisible to cluster methods, and does not fit into the accepted classification of Luminal A/B, Normal-like subtypes of ER(+) breast cancers. We denote the group as c-MYB(+) breast cancer.

  4. NOAA Photo Library - It's A Small World Collection

    Science.gov Websites

    words Geodesy For children the world can seem like a huge place. For those lucky enough to have a back larger neighborhood and discover the outside world. Until a few short centuries ago, mankind was locked in a figurative backyard, mired in superstition and ignorance of the nature of the world about us

  5. A Brief Historical Introduction to Euler's Formula for Polyhedra, Topology, Graph Theory and Networks

    ERIC Educational Resources Information Center

    Debnath, Lokenath

    2010-01-01

    This article is essentially devoted to a brief historical introduction to Euler's formula for polyhedra, topology, theory of graphs and networks with many examples from the real-world. Celebrated Konigsberg seven-bridge problem and some of the basic properties of graphs and networks for some understanding of the macroscopic behaviour of real…

  6. Identifying topological-band insulator transitions in silicene and other 2D gapped Dirac materials by means of Rényi-Wehrl entropy

    NASA Astrophysics Data System (ADS)

    Calixto, M.; Romera, E.

    2015-02-01

    We propose a new method to identify transitions from a topological insulator to a band insulator in silicene (the silicon equivalent of graphene) in the presence of perpendicular magnetic and electric fields, by using the Rényi-Wehrl entropy of the quantum state in phase space. Electron-hole entropies display an inversion/crossing behavior at the charge neutrality point for any Landau level, and the combined entropy of particles plus holes turns out to be maximum at this critical point. The result is interpreted in terms of delocalization of the quantum state in phase space. The entropic description presented in this work will be valid in general 2D gapped Dirac materials, with a strong intrinsic spin-orbit interaction, isostructural with silicene.

  7. Big Policies and a Small World: An Analysis of Policy Problems and Solutions in Physical Education

    ERIC Educational Resources Information Center

    Penney, Dawn

    2017-01-01

    This paper uses Ball's [1998. Big policies/small world: An introduction to international perspectives in education policy. "Comparative Education," 34(2), 119-130] policy analysis and Bernstein's [1990. "The structuring of pedagogic discourse. Volume IV class, codes and control". London: Routledge; 2000, "Pedagogy,…

  8. Scaling of Directed Dynamical Small-World Networks with Random Responses

    NASA Astrophysics Data System (ADS)

    Zhu, Chen-Ping; Xiong, Shi-Jie; Tian, Ying-Jie; Li, Nan; Jiang, Ke-Sheng

    2004-05-01

    A dynamical model of small-world networks, with directed links which describe various correlations in social and natural phenomena, is presented. Random responses of sites to the input message are introduced to simulate real systems. The interplay of these ingredients results in the collective dynamical evolution of a spinlike variable S(t) of the whole network. The global average spreading length s and average spreading time s are found to scale as p-αln(N with different exponents. Meanwhile, S(t) behaves in a duple scaling form for N≫N*: S˜f(p-βqγt˜), where p and q are rewiring and external parameters, α, β, and γ are scaling exponents, and f(t˜) is a universal function. Possible applications of the model are discussed.

  9. Transmission of severe acute respiratory syndrome in dynamical small-world networks

    NASA Astrophysics Data System (ADS)

    Masuda, Naoki; Konno, Norio; Aihara, Kazuyuki

    2004-03-01

    The outbreak of severe acute respiratory syndrome (SARS) is still threatening the world because of a possible resurgence. In the current situation that effective medical treatments such as antiviral drugs are not discovered yet, dynamical features of the epidemics should be clarified for establishing strategies for tracing, quarantine, isolation, and regulating social behavior of the public at appropriate costs. Here we propose a network model for SARS epidemics and discuss why superspreaders emerged and why SARS spread especially in hospitals, which were key factors of the recent outbreak. We suggest that superspreaders are biologically contagious patients, and they may amplify the spreads by going to potentially contagious places such as hospitals. To avoid mass transmission in hospitals, it may be a good measure to treat suspected cases without hospitalizing them. Finally, we indicate that SARS probably propagates in small-world networks associated with human contacts and that the biological nature of individuals and social group properties are factors more important than the heterogeneous rates of social contacts among individuals. This is in marked contrast with epidemics of sexually transmitted diseases or computer viruses to which scale-free network models often apply.

  10. Aberrant topological patterns of brain structural network in temporal lobe epilepsy.

    PubMed

    Yasuda, Clarissa Lin; Chen, Zhang; Beltramini, Guilherme Coco; Coan, Ana Carolina; Morita, Marcia Elisabete; Kubota, Bruno; Bergo, Felipe; Beaulieu, Christian; Cendes, Fernando; Gross, Donald William

    2015-12-01

    Although altered large-scale brain network organization in patients with temporal lobe epilepsy (TLE) has been shown using morphologic measurements such as cortical thickness, these studies, have not included critical subcortical structures (such as hippocampus and amygdala) and have had relatively small sample sizes. Here, we investigated differences in topological organization of the brain volumetric networks between patients with right TLE (RTLE) and left TLE (LTLE) with unilateral hippocampal atrophy. We performed a cross-sectional analysis of 86 LTLE patients, 70 RTLE patients, and 116 controls. RTLE and LTLE groups were balanced for gender (p = 0.64), seizure frequency (Mann-Whitney U test, p = 0.94), age (p = 0.39), age of seizure onset (p = 0.21), and duration of disease (p = 0.69). Brain networks were constructed by thresholding correlation matrices of volumes from 80 cortical/subcortical regions (parcellated with Freesurfer v5.3 https://surfer.nmr.mgh.harvard.edu/) that were then analyzed using graph theoretical approaches. We identified reduced cortical/subcortical connectivity including bilateral hippocampus in both TLE groups, with the most significant interregional correlation increases occurring within the limbic system in LTLE and contralateral hemisphere in RTLE. Both TLE groups demonstrated less optimal topological organization, with decreased global efficiency and increased local efficiency and clustering coefficient. LTLE also displayed a more pronounced network disruption. Contrary to controls, hub nodes in both TLE groups were not distributed across whole brain, but rather found primarily in the paralimbic/limbic and temporal association cortices. Regions with increased centrality were concentrated in occipital lobes for LTLE and contralateral limbic/temporal areas for RTLE. These findings provide first evidence of altered topological organization of the whole brain volumetric network in TLE, with disruption of the coordinated patterns of

  11. Visualizing vector field topology in fluid flows

    NASA Technical Reports Server (NTRS)

    Helman, James L.; Hesselink, Lambertus

    1991-01-01

    Methods of automating the analysis and display of vector field topology in general and flow topology in particular are discussed. Two-dimensional vector field topology is reviewed as the basis for the examination of topology in three-dimensional separated flows. The use of tangent surfaces and clipping in visualizing vector field topology in fluid flows is addressed.

  12. Stochastic resonance on a modular neuronal network of small-world subnetworks with a subthreshold pacemaker

    NASA Astrophysics Data System (ADS)

    Yu, Haitao; Wang, Jiang; Liu, Chen; Deng, Bin; Wei, Xile

    2011-12-01

    We study the phenomenon of stochastic resonance on a modular neuronal network consisting of several small-world subnetworks with a subthreshold periodic pacemaker. Numerical results show that the correlation between the pacemaker frequency and the dynamical response of the network is resonantly dependent on the intensity of additive spatiotemporal noise. This effect of pacemaker-driven stochastic resonance of the system depends extensively on the local and the global network structure, such as the intra- and inter-coupling strengths, rewiring probability of individual small-world subnetwork, the number of links between different subnetworks, and the number of subnetworks. All these parameters play a key role in determining the ability of the network to enhance the noise-induced outreach of the localized subthreshold pacemaker, and only they bounded to a rather sharp interval of values warrant the emergence of the pronounced stochastic resonance phenomenon. Considering the rather important role of pacemakers in real-life, the presented results could have important implications for many biological processes that rely on an effective pacemaker for their proper functioning.

  13. Symmetric Topological Phases and Tensor Network States

    NASA Astrophysics Data System (ADS)

    Jiang, Shenghan

    Classification and simulation of quantum phases are one of main themes in condensed matter physics. Quantum phases can be distinguished by their symmetrical and topological properties. The interplay between symmetry and topology in condensed matter physics often leads to exotic quantum phases and rich phase diagrams. Famous examples include quantum Hall phases, spin liquids and topological insulators. In this thesis, I present our works toward a more systematically understanding of symmetric topological quantum phases in bosonic systems. In the absence of global symmetries, gapped quantum phases are characterized by topological orders. Topological orders in 2+1D are well studied, while a systematically understanding of topological orders in 3+1D is still lacking. By studying a family of exact solvable models, we find at least some topological orders in 3+1D can be distinguished by braiding phases of loop excitations. In the presence of both global symmetries and topological orders, the interplay between them leads to new phases termed as symmetry enriched topological (SET) phases. We develop a framework to classify a large class of SET phases using tensor networks. For each tensor class, we can write down generic variational wavefunctions. We apply our method to study gapped spin liquids on the kagome lattice, which can be viewed as SET phases of on-site symmetries as well as lattice symmetries. In the absence of topological order, symmetry could protect different topological phases, which are often referred to as symmetry protected topological (SPT) phases. We present systematic constructions of tensor network wavefunctions for bosonic symmetry protected topological (SPT) phases respecting both onsite and spatial symmetries.

  14. Atomic-Ordering-Induced Quantum Phase Transition between Topological Crystalline Insulator and Z 2 Topological Insulator

    NASA Astrophysics Data System (ADS)

    Deng, Hui-Xiong; Song, Zhi-Gang; Li, Shu-Shen; Wei, Su-Huai; Luo, Jun-Wei

    2018-05-01

    Topological phase transition in a single material usually refers to transitions between a trivial band insulator and a topological Dirac phase, but the transition may also occur between different classes of topological Dirac phases. However, it is a fundamental challenge to realize quantum transition between Z2 nontrivial topological insulator (TI) and topological crystalline insulator (TCI) in one material because Z2 TI and TCI are hardly both co-exist in a single material due to their contradictory requirement on the number of band inversions. The Z2 TIs must have an odd number of band inversions over all the time-reversal invariant momenta, whereas, the newly discovered TCIs, as a distinct class of the topological Dirac materials protected by the underlying crystalline symmetry, owns an even number of band inversions. Here, take PbSnTe2 alloy as an example, we show that at proper alloy composition the atomic-ordering is an effective way to tune the symmetry of the alloy so that we can electrically switch between TCI phase and Z2 TI phase when the alloy is ordered from a random phase into a stable CuPt phase. Our results suggest that atomic-ordering provides a new platform to switch between different topological phases.

  15. Feasibility of self-correcting quantum memory and thermal stability of topological order

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoshida, Beni, E-mail: rouge@mit.edu

    2011-10-15

    Recently, it has become apparent that the thermal stability of topologically ordered systems at finite temperature, as discussed in condensed matter physics, can be studied by addressing the feasibility of self-correcting quantum memory, as discussed in quantum information science. Here, with this correspondence in mind, we propose a model of quantum codes that may cover a large class of physically realizable quantum memory. The model is supported by a certain class of gapped spin Hamiltonians, called stabilizer Hamiltonians, with translation symmetries and a small number of ground states that does not grow with the system size. We show that themore » model does not work as self-correcting quantum memory due to a certain topological constraint on geometric shapes of its logical operators. This quantum coding theoretical result implies that systems covered or approximated by the model cannot have thermally stable topological order, meaning that systems cannot be stable against both thermal fluctuations and local perturbations simultaneously in two and three spatial dimensions. - Highlights: > We define a class of physically realizable quantum codes. > We determine their coding and physical properties completely. > We establish the connection between topological order and self-correcting memory. > We find they do not work as self-correcting quantum memory. > We find they do not have thermally stable topological order.« less

  16. Disorganized cortical thickness covariance network in major depressive disorder implicated by aberrant hubs in large-scale networks

    PubMed Central

    Wang, Tao; Wang, Kangcheng; Qu, Hang; Zhou, Jingjing; Li, Qi; Deng, Zhou; Du, Xue; Lv, Fajin; Ren, Gaoping; Guo, Jing; Qiu, Jiang; Xie, Peng

    2016-01-01

    Major depressive disorder is associated with abnormal anatomical and functional connectivity, yet alterations in whole cortical thickness topology remain unknown. Here, we examined cortical thickness in medication-free adult depression patients (n = 76) and matched healthy controls (n = 116). Inter-regional correlation was performed to construct brain networks. By applying graph theory analysis, global (i.e., small-worldness) and regional (centrality) topology was compared between major depressive disorder patients and healthy controls. We found that in depression patients, topological organization of the cortical thickness network shifted towards randomness, and lower small-worldness was driven by a decreased clustering coefficient. Consistently, altered nodal centrality was identified in the isthmus of the cingulate cortex, insula, supra-marginal gyrus, middle temporal gyrus and inferior parietal gyrus, all of which are components within the default mode, salience and central executive networks. Disrupted nodes anchored in the default mode and executive networks were associated with depression severity. The brain systems involved sustain core symptoms in depression and implicate a structural basis for depression. Our results highlight the possibility that developmental and genetic factors are crucial to understand the neuropathology of depression. PMID:27302485

  17. A graph edit dictionary for correcting errors in roof topology graphs reconstructed from point clouds

    NASA Astrophysics Data System (ADS)

    Xiong, B.; Oude Elberink, S.; Vosselman, G.

    2014-07-01

    In the task of 3D building model reconstruction from point clouds we face the problem of recovering a roof topology graph in the presence of noise, small roof faces and low point densities. Errors in roof topology graphs will seriously affect the final modelling results. The aim of this research is to automatically correct these errors. We define the graph correction as a graph-to-graph problem, similar to the spelling correction problem (also called the string-to-string problem). The graph correction is more complex than string correction, as the graphs are 2D while strings are only 1D. We design a strategy based on a dictionary of graph edit operations to automatically identify and correct the errors in the input graph. For each type of error the graph edit dictionary stores a representative erroneous subgraph as well as the corrected version. As an erroneous roof topology graph may contain several errors, a heuristic search is applied to find the optimum sequence of graph edits to correct the errors one by one. The graph edit dictionary can be expanded to include entries needed to cope with errors that were previously not encountered. Experiments show that the dictionary with only fifteen entries already properly corrects one quarter of erroneous graphs in about 4500 buildings, and even half of the erroneous graphs in one test area, achieving as high as a 95% acceptance rate of the reconstructed models.

  18. Topological Behavior of Plasmid DNA

    PubMed Central

    Higgins, N. Patrick; Vologodskii, Alexander V.

    2015-01-01

    The discovery of the B-form structure of DNA by Watson and Crick led to an explosion of research on nucleic acids in the fields of biochemistry, biophysics, and genetics. Powerful techniques were developed to reveal a myriad of different structural conformations that change B-DNA as it is transcribed, replicated, and recombined and as sister chromosomes are moved into new daughter cell compartments during cell division. This article links the original discoveries of superhelical structure and molecular topology to non-B form DNA structure and contemporary biochemical and biophysical techniques. The emphasis is on the power of plasmids for studying DNA structure and function. The conditions that trigger the formation of alternative DNA structures such as left-handed Z-DNA, inter- and intra-molecular triplexes, triple-stranded DNA, and linked catenanes and hemicatenanes are explained. The DNA dynamics and topological issues are detailed for stalled replication forks and for torsional and structural changes on DNA in front of and behind a transcription complex and a replisome. The complex and interconnected roles of topoisomerases and abundant small nucleoid association proteins are explained. And methods are described for comparing in vivo and in vitro reactions to probe and understand the temporal pathways of DNA and chromosome chemistry that occur inside living cells. PMID:26104708

  19. Topological inflation with graceful exit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marunović, Anja; Prokopec, Tomislav, E-mail: a.marunovic@uu.nl, E-mail: t.prokopec@uu.nl

    We investigate a class of models of topological inflation in which a super-Hubble-sized global monopole seeds inflation. These models are attractive since inflation starts from rather generic initial conditions, but their not so attractive feature is that, unless symmetry is again restored, inflation never ends. In this work we show that, in presence of another nonminimally coupled scalar field, that is both quadratically and quartically coupled to the Ricci scalar, inflation naturally ends, representing an elegant solution to the graceful exit problem of topological inflation. While the monopole core grows during inflation, the growth stops after inflation, such that themore » monopole eventually enters the Hubble radius, and shrinks to its Minkowski space size, rendering it immaterial for the subsequent Universe's dynamics. Furthermore, we find that our model can produce cosmological perturbations that source CMB temperature fluctuations and seed large scale structure statistically consistent (within one standard deviation) with all available data. In particular, for small and (in our convention) negative nonminimal couplings, the scalar spectral index can be as large as n {sub s} ≅ 0.955, which is about one standard deviation lower than the central value quoted by the most recent Planck Collaboration.« less

  20. Superconducting proximity effect in a topological insulator using Fe(Te, Se)

    NASA Astrophysics Data System (ADS)

    Zhao, He; Rachmilowitz, Bryan; Ren, Zheng; Han, Ruobin; Schneeloch, J.; Zhong, Ruidan; Gu, Genda; Wang, Ziqiang; Zeljkovic, Ilija

    2018-06-01

    Interest in the superconducting proximity effect has recently been reignited by theoretical predictions that it could be used to achieve topological superconductivity. Low-Tc superconductors have predominantly been used in this effort, but small energy scales of ˜1 meV have hindered the characterization of the emergent electronic phase, limiting it to extremely low temperatures. In this work, we use molecular beam epitaxy to grow topological insulator B i2T e3 in a range of thicknesses on top of a high-Tc superconductor Fe(Te,Se). Using scanning tunneling microscopy and spectroscopy, we detect Δind as high as ˜3.5 meV, which is the largest reported gap induced by proximity to an s -wave superconductor to date. We find that Δind decays with B i2T e3 thickness, but remains finite even after the topological surface states have been formed. Finally, by imaging the scattering and interference of surface state electrons, we provide a microscopic visualization of the fully gapped B i2T e3 surface state due to Cooper pairing. Our results establish Fe-based high-Tc superconductors as a promising new platform for realizing high-Tc topological superconductivity.

  1. Topological phase diagram and saddle point singularity in a tunable topological crystalline insulator

    DOE PAGES

    Neupane, Madhab; Xu, Su-Yang; Sankar, R.; ...

    2015-08-20

    Here we report the evolution of the surface electronic structure and surface material properties of a topological crystalline insulator (TCI), Pb 1more » $${-}$$xSnxSe, as a function of various material parameters including composition x, temperature T , and crystal structure. Our spectroscopic data demonstrate the electronic ground-state condition for the saddle point singularity, the tunability of surface chemical potential, and the surface states’ response to circularly polarized light. Our results show that each material parameter can tune the system between the trivial and topological phase in a distinct way, unlike that seen in Bi 2Se 3 and related compounds, leading to a rich topological phase diagram. Our systematic studies of the TCI Pb 1$${-}$$xSnxSe are a valuable materials guide to realize new topological phenomena.« less

  2. Impact of Partial Time Delay on Temporal Dynamics of Watts-Strogatz Small-World Neuronal Networks

    NASA Astrophysics Data System (ADS)

    Yan, Hao; Sun, Xiaojuan

    2017-06-01

    In this paper, we mainly discuss effects of partial time delay on temporal dynamics of Watts-Strogatz (WS) small-world neuronal networks by controlling two parameters. One is the time delay τ and the other is the probability of partial time delay pdelay. Temporal dynamics of WS small-world neuronal networks are discussed with the aid of temporal coherence and mean firing rate. With the obtained simulation results, it is revealed that for small time delay τ, the probability pdelay could weaken temporal coherence and increase mean firing rate of neuronal networks, which indicates that it could improve neuronal firings of the neuronal networks while destroying firing regularity. For large time delay τ, temporal coherence and mean firing rate do not have great changes with respect to pdelay. Time delay τ always has great influence on both temporal coherence and mean firing rate no matter what is the value of pdelay. Moreover, with the analysis of spike trains and histograms of interspike intervals of neurons inside neuronal networks, it is found that the effects of partial time delays on temporal coherence and mean firing rate could be the result of locking between the period of neuronal firing activities and the value of time delay τ. In brief, partial time delay could have great influence on temporal dynamics of the neuronal networks.

  3. Topological order following a quantum quench

    NASA Astrophysics Data System (ADS)

    Tsomokos, Dimitris I.; Hamma, Alioscia; Zhang, Wen; Haas, Stephan; Fazio, Rosario

    2009-12-01

    We determine the conditions under which topological order survives a rapid quantum quench. Specifically, we consider the case where a quantum spin system is prepared in the ground state of the toric code model and, after the quench, it evolves with a Hamiltonian that does not support topological order. We provide analytical results supported by numerical evidence for a variety of quench Hamiltonians. The robustness of topological order under nonequilibrium situations is tested by studying the topological entropy and a dynamical measure, which makes use of the similarity between partial density matrices obtained from different topological sectors.

  4. Cost intensity of identifying contraindications to driving a company car through psychological tests on the basis of real-world data in Poland.

    PubMed

    Juszczyk, Grzegorz; Czerw, Aleksandra; Tatara, Tomasz; Duda-Zalewska, Aneta; Walusiak-Skorupa, Joanna; Słoniewski, Robert; Staniszewska, Anna; Olejniczak, Dominik; Religioni, Urszula

    2017-12-01

    The study objective was to determine the cost intensity of identifying contraindications to fleet car driving in preventive care. The objective of a psychological examination is to identify impaired psychomotor function as well as any intellectual, cognitive or emotional incapacities, which may seriously impede safety. Real-world data were collected from the healthcare provider in Poland. A total of 8111 anonymous records from psychomotor tests performed between January 1 and December 31, 2012 were analysed. The number needed to screen to identify one person with contraindications to driving was 737. An individual examination costs PLN 150, thus the estimated cost of identifying one case was PLN 110,550 (EUR 25,000). The average number of tests in a small enterprise with 20-50 fleet cars was estimated at 5-25 in a 5-year period and their cost at PLN 3750 (PLN 750 annually). Health check-ups include ophthalmological and neurological consultations; therefore, psychological examination of fleet car drivers may be considered excessive due to cost and limited preventive value. High costs may be burdensome mainly to larger companies. A final decision regarding necessity of psychological testing should be preceded by medical assessment of the risk of work accidents.

  5. Topological transitions induced by antiferromagnetism in a thin-film topological insulator

    NASA Astrophysics Data System (ADS)

    Yin, Gen; He, Qinglin; Yu, Luyan; Pan, Lei; Wang, Kang

    Ferromagnetism introduced in topological insulators (TIs) opens a non-trivial exchange band gap, providing an exciting platform to control the topological order through an external magnetic field. The magnetization induces a topological transition that breaks time-reversal symmetry, resulting in anomalous Hall effects. Recently, it was experimentally shown that the surface of an antiferromagnetic (AFM) thin film can magnetize the surface Dirac fermions in a TI thin film similar to the case induced by ferromagnetism. Here, we show that when a TI thin film is sandwiched between two antiferromagnetic layers, an unsynchronized magnetic reversal introduces two intermediate spin configurations during the scan of the external field, resulting in a new topological phase with second Chern numbers. This topological phase introduces two counter-propagating chiral edge modes inside the exchange gap, changing the total number of transport channels drastically when the fermi level is close to the Dirac point. Induced by this change, the magnetoresistance of the channel presents an antisymmetric feature during the field scan. With the the help of the high ordering temperature of AFM layers, this transport signature of the phase transition persists up to 90K experimentally. This work is supported by (i) SHINES, an EFRC by US-DOE, Office of Science, BES, #SC0012670. (ii) US-NSF (DMR-1411085), (iii) ARO program W911NF-15-1-10561, and (iv) FAME Center in STARnet, an SRC program by MARCO and DARPA.

  6. An ensemble framework for identifying essential proteins.

    PubMed

    Zhang, Xue; Xiao, Wangxin; Acencio, Marcio Luis; Lemke, Ney; Wang, Xujing

    2016-08-25

    Many centrality measures have been proposed to mine and characterize the correlations between network topological properties and protein essentiality. However, most of them show limited prediction accuracy, and the number of common predicted essential proteins by different methods is very small. In this paper, an ensemble framework is proposed which integrates gene expression data and protein-protein interaction networks (PINs). It aims to improve the prediction accuracy of basic centrality measures. The idea behind this ensemble framework is that different protein-protein interactions (PPIs) may show different contributions to protein essentiality. Five standard centrality measures (degree centrality, betweenness centrality, closeness centrality, eigenvector centrality, and subgraph centrality) are integrated into the ensemble framework respectively. We evaluated the performance of the proposed ensemble framework using yeast PINs and gene expression data. The results show that it can considerably improve the prediction accuracy of the five centrality measures individually. It can also remarkably increase the number of common predicted essential proteins among those predicted by each centrality measure individually and enable each centrality measure to find more low-degree essential proteins. This paper demonstrates that it is valuable to differentiate the contributions of different PPIs for identifying essential proteins based on network topological characteristics. The proposed ensemble framework is a successful paradigm to this end.

  7. Scaling of Topologically Similar Functional Modules Defines Mouse Primary Auditory and Somatosensory Microcircuitry

    PubMed Central

    Sadovsky, Alexander J.

    2013-01-01

    Mapping the flow of activity through neocortical microcircuits provides key insights into the underlying circuit architecture. Using a comparative analysis we determined the extent to which the dynamics of microcircuits in mouse primary somatosensory barrel field (S1BF) and auditory (A1) neocortex generalize. We imaged the simultaneous dynamics of up to 1126 neurons spanning multiple columns and layers using high-speed multiphoton imaging. The temporal progression and reliability of reactivation of circuit events in both regions suggested common underlying cortical design features. We used circuit activity flow to generate functional connectivity maps, or graphs, to test the microcircuit hypothesis within a functional framework. S1BF and A1 present a useful test of the postulate as both regions map sensory input anatomically, but each area appears organized according to different design principles. We projected the functional topologies into anatomical space and found benchmarks of organization that had been previously described using physiology and anatomical methods, consistent with a close mapping between anatomy and functional dynamics. By comparing graphs representing activity flow we found that each region is similarly organized as highlighted by hallmarks of small world, scale free, and hierarchical modular topologies. Models of prototypical functional circuits from each area of cortex were sufficient to recapitulate experimentally observed circuit activity. Convergence to common behavior by these models was accomplished using preferential attachment to scale from an auditory up to a somatosensory circuit. These functional data imply that the microcircuit hypothesis be framed as scalable principles of neocortical circuit design. PMID:23986241

  8. Interrogating the topological robustness of gene regulatory circuits by randomization

    PubMed Central

    Levine, Herbert; Onuchic, Jose N.

    2017-01-01

    One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example, cell-fate decision-making and signal transduction, through multiple layers of regulation involving many genes. Despite the combinatorial complexity of gene regulation, its quantitative behavior has been typically studied on the basis of experimentally verified core gene regulatory circuitry, composed of a small set of important elements. It is still unclear how such a core circuit operates in the presence of many other regulatory molecules and in a crowded and noisy cellular environment. Here we report a new computational method, named random circuit perturbation (RACIPE), for interrogating the robust dynamical behavior of a gene regulatory circuit even without accurate measurements of circuit kinetic parameters. RACIPE generates an ensemble of random kinetic models corresponding to a fixed circuit topology, and utilizes statistical tools to identify generic properties of the circuit. By applying RACIPE to simple toggle-switch-like motifs, we observed that the stable states of all models converge to experimentally observed gene state clusters even when the parameters are strongly perturbed. RACIPE was further applied to a proposed 22-gene network of the Epithelial-to-Mesenchymal Transition (EMT), from which we identified four experimentally observed gene states, including the states that are associated with two different types of hybrid Epithelial/Mesenchymal phenotypes. Our results suggest that dynamics of a gene circuit is mainly determined by its topology, not by detailed circuit parameters. Our work provides a theoretical foundation for circuit-based systems biology modeling. We anticipate RACIPE to be a powerful tool to predict and decode circuit design principles in an unbiased manner, and to quantitatively evaluate the robustness and heterogeneity of gene expression. PMID:28362798

  9. Network topology of olivine-basalt partial melts

    NASA Astrophysics Data System (ADS)

    Skemer, Philip; Chaney, Molly M.; Emmerich, Adrienne L.; Miller, Kevin J.; Zhu, Wen-lu

    2017-07-01

    The microstructural relationship between melt and solid grains in partially molten rocks influences many physical properties, including permeability, rheology, electrical conductivity and seismic wave speeds. In this study, the connectivity of melt networks in the olivine-basalt system is explored using a systematic survey of 3-D X-ray microtomographic data. Experimentally synthesized samples with 2 and 5 vol.% melt are analysed as a series of melt tubules intersecting at nodes. Each node is characterized by a coordination number (CN), which is the number of melt tubules that intersect at that location. Statistically representative volumes are described by coordination number distributions (CND). Polyhedral grains can be packed in many configurations yielding different CNDs, however widely accepted theory predicts that systems with small dihedral angles, such as olivine-basalt, should exhibit a predominant CN of four. In this study, melt objects are identified with CN = 2-8, however more than 50 per cent are CN = 4, providing experimental verification of this theoretical prediction. A conceptual model that considers the role of heterogeneity in local grain size and melt fraction is proposed to explain the formation of nodes with CN ≠ 4. Correctly identifying the melt network topology is essential to understanding the relationship between permeability and porosity, and hence the transport properties of partial molten mantle rocks.

  10. Insulator function and topological domain border strength scale with architectural protein occupancy

    PubMed Central

    2014-01-01

    Background Chromosome conformation capture studies suggest that eukaryotic genomes are organized into structures called topologically associating domains. The borders of these domains are highly enriched for architectural proteins with characterized roles in insulator function. However, a majority of architectural protein binding sites localize within topological domains, suggesting sites associated with domain borders represent a functionally different subclass of these regulatory elements. How topologically associating domains are established and what differentiates border-associated from non-border architectural protein binding sites remain unanswered questions. Results By mapping the genome-wide target sites for several Drosophila architectural proteins, including previously uncharacterized profiles for TFIIIC and SMC-containing condensin complexes, we uncover an extensive pattern of colocalization in which architectural proteins establish dense clusters at the borders of topological domains. Reporter-based enhancer-blocking insulator activity as well as endogenous domain border strength scale with the occupancy level of architectural protein binding sites, suggesting co-binding by architectural proteins underlies the functional potential of these loci. Analyses in mouse and human stem cells suggest that clustering of architectural proteins is a general feature of genome organization, and conserved architectural protein binding sites may underlie the tissue-invariant nature of topologically associating domains observed in mammals. Conclusions We identify a spectrum of architectural protein occupancy that scales with the topological structure of chromosomes and the regulatory potential of these elements. Whereas high occupancy architectural protein binding sites associate with robust partitioning of topologically associating domains and robust insulator function, low occupancy sites appear reserved for gene-specific regulation within topological domains. PMID

  11. Prediction, synthesis and characterization of new topological materials

    NASA Astrophysics Data System (ADS)

    Gibson, Quinn Davis

    Over the past few years, a rediscovery of the concept of topology as it applies to the electronic structure of materials has created an explosion of research and discovery of new materials properties. While this field has been mainly of interest to the condensed matter physics community, this work explores it from a materials chemistry perspective, to both develop new materials, via a combination of computation, synthesis and measurement, to understand how the electronic topology can relate to structure and bonding. As such, adding chemical complexity to existing topological materials has been a focus of this study. In order to expand upon the archetypal topological insulator family of Bi2X3 (X=Se,Te), the super lattice materials, which contain alternating layers of Bi2 or Sb2 and Bi 2X3 or Sb2Te3, were investigated, revealing novel properties. The compound Bi4Se3 was shown to have termination dependent surface states, revealing a relationship between the nature of the surface states and the chemical nature of the surface, as well as novel mirror symmetry protected surface states. The 2:1 family (in the Sb2Te structure) were shown to be new topological insulators, with a novel Sb/Bi ordering when Bi is substituted for Sb in Sb2Te. Finally the 1:1 family was shown to, unexpectedly, be strong topological insulators, despite the theoretical prediction that they are weak topological insulators. Furthermore, other materials families were investigated as topological insulators, such as the chimney ladder family. Ir4Ge5 is identified as a likely candidate, and Ru2Sn3 was shown to have novel, quasi one-dimensional surface states. The exact reason for the existence of these states is not known and is under investigation. Finally, possible 3D Dirac and Weyl semi-metals were investigated. A set of rules to predict 3D Dirac semi-metals were developed, and Cd3 As2 was experimentally verified as the first of this kind of material. Studies towards Weyl semi-metals involved the

  12. A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E Protein

    PubMed Central

    Ruch, Travis R.; Machamer, Carolyn E.

    2012-01-01

    The coronavirus E protein is a small membrane protein with a single predicted hydrophobic domain (HD), and has a poorly defined role in infection. The E protein is thought to promote virion assembly, which occurs in the Golgi region of infected cells. It has also been implicated in the release of infectious particles after budding. The E protein has ion channel activity in vitro, although a role for channel activity in infection has not been established. Furthermore, the membrane topology of the E protein is of considerable debate, and the protein may adopt more than one topology during infection. We previously showed that the HD of the infectious bronchitis virus (IBV) E protein is required for the efficient release of infectious virus, an activity that correlated with disruption of the secretory pathway. Here we report that a single residue within the hydrophobic domain, Thr16, is required for secretory pathway disruption. Substitutions of other residues for Thr16 were not tolerated. Mutations of Thr16 did not impact virus assembly as judged by virus-like particle production, suggesting that alteration of secretory pathway and assembly are independent activities. We also examined how the membrane topology of IBV E affected its function by generating mutant versions that adopted either a transmembrane or membrane hairpin topology. We found that a transmembrane topology was required for disrupting the secretory pathway, but was less efficient for virus-like particle production. The hairpin version of E was unable to disrupt the secretory pathway or produce particles. The findings reported here identify properties of the E protein that are important for its function, and provide insight into how the E protein may perform multiple roles during infection. PMID:22570613

  13. Engineering multiple topological phases in nanoscale Van der Waals heterostructures: realisation of α-antimonene

    NASA Astrophysics Data System (ADS)

    Märkl, T.; Kowalczyk, P. J.; Le Ster, M.; Mahajan, I. V.; Pirie, H.; Ahmed, Z.; Bian, G.; Wang, X.; Chiang, T.-C.; Brown, S. A.

    2018-01-01

    Van der Waals heterostructures have recently been identified as providing many opportunities to create new two-dimensional materials, and in particular to produce materials with topologically-interesting states. Here we show that it is possible to create such heterostructures with multiple topological phases in a single nanoscale island. We discuss their growth within the framework of diffusion-limited aggregation, the formation of moiré patterns due to the differing crystallographies of the materials comprising the heterostructure, and the potential to engineer both the electronic structure as well as local variations of topological order. In particular we show that it is possible to build islands which include both the hexagonal β- and rectangular α-forms of antimonene, on top of the topological insulator α-bismuthene. This is the first experimental realisation of α-antimonene, and we show that it is a topologically non-trivial material in the quantum spin Hall class.

  14. Establishing mesh topology in multi-material cells: enabling technology for robust and accurate multi-material simulations

    DOE PAGES

    Kikinzon, Evgeny; Shashkov, Mikhail Jurievich; Garimella, Rao Veerabhadra

    2018-05-29

    Real world problems are typically multi-material, combining materials such as gases, liquids and solids that have very different properties. The material interfaces may be fixed in time or can be a part of the solution, as in fluid-structure interactions or air-water dynamics, and therefore move and change shape. In such problems the computational mesh may be non-conformal to interfaces due to complexity of these interfaces, presence of small fractions of materials, or because the mesh does not move with the flow, as in the arbitrary Lagrangian–Eulerian (ALE) methods. In order to solve problems of interest on such meshes, interface reconstructionmore » methods are usually used to recover an approximation of material regions within the cells. For a cell intersecting multiple material regions, these approximations of contained subregions can be considered as single-material subcells in a local mesh that we call a minimesh. In this paper, we discuss some of the requirements that discretization methods have on topological information in the resulting hierarchical meshes and present an approach that allows incorporating the buildup of sufficiently detailed topology into the nested dissections based PLIC-type reconstruction algorithms (e.g. Volume-of-Fluid, Moment-of-Fluid) in an efficient and robust manner. Specifically, we describe the X-MOF interface reconstruction algorithm in 2D, which extends the Moment-Of-Fluid (MOF) method to include the topology of minimeshes created inside of multi-material cells and parent-child relations between corresponding mesh entities on different hierarchy levels. X-MOF retains the property of being local to a cell and not requiring external communication, which makes it suitable for massively parallel applications. Here, we demonstrate some scaling results for the X-MOF implementation in Tangram, a modern interface reconstruction framework for exascale computing.« less

  15. Establishing mesh topology in multi-material cells: enabling technology for robust and accurate multi-material simulations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kikinzon, Evgeny; Shashkov, Mikhail Jurievich; Garimella, Rao Veerabhadra

    Real world problems are typically multi-material, combining materials such as gases, liquids and solids that have very different properties. The material interfaces may be fixed in time or can be a part of the solution, as in fluid-structure interactions or air-water dynamics, and therefore move and change shape. In such problems the computational mesh may be non-conformal to interfaces due to complexity of these interfaces, presence of small fractions of materials, or because the mesh does not move with the flow, as in the arbitrary Lagrangian–Eulerian (ALE) methods. In order to solve problems of interest on such meshes, interface reconstructionmore » methods are usually used to recover an approximation of material regions within the cells. For a cell intersecting multiple material regions, these approximations of contained subregions can be considered as single-material subcells in a local mesh that we call a minimesh. In this paper, we discuss some of the requirements that discretization methods have on topological information in the resulting hierarchical meshes and present an approach that allows incorporating the buildup of sufficiently detailed topology into the nested dissections based PLIC-type reconstruction algorithms (e.g. Volume-of-Fluid, Moment-of-Fluid) in an efficient and robust manner. Specifically, we describe the X-MOF interface reconstruction algorithm in 2D, which extends the Moment-Of-Fluid (MOF) method to include the topology of minimeshes created inside of multi-material cells and parent-child relations between corresponding mesh entities on different hierarchy levels. X-MOF retains the property of being local to a cell and not requiring external communication, which makes it suitable for massively parallel applications. Here, we demonstrate some scaling results for the X-MOF implementation in Tangram, a modern interface reconstruction framework for exascale computing.« less

  16. Topological phase transition and the effect of Hubbard interactions on the one-dimensional topological Kondo insulator

    NASA Astrophysics Data System (ADS)

    Pillay, Jason C.; McCulloch, Ian P.

    2018-05-01

    The effect of a local Kondo coupling and Hubbard interaction on the topological phase of the one-dimensional topological Kondo insulator (TKI) is numerically investigated using the infinite matrix-product state density-matrix renormalization group algorithm. The ground state of the TKI is a symmetry-protected topological (SPT) phase protected by inversion symmetry. It is found that on its own, the Hubbard interaction that tends to force fermions into a one-charge per site order is insufficient to destroy the SPT phase. However, when the local Kondo Hamiltonian term that favors a topologically trivial ground state with a one-charge per site order is introduced, the Hubbard interaction assists in the destruction of the SPT phase. This topological phase transition occurs in the charge sector where the correlation length of the charge excitation diverges while the correlation length of the spin excitation remains finite. The critical exponents, central charge, and the phase diagram separating the SPT phase from the topologically trivial phase are presented.

  17. Identifying vulnerable Asian Americans under Health Care Reform: working in small businesses and health care coverage.

    PubMed

    Cook, Won Kim; Tseng, Winston; Ko Chin, Kathy; John, Iyanrick; Chung, Corina

    2014-11-01

    Working in small businesses has been identified as a key factor for low coverage rates in immigrant communities. In this study, we identify specific cultural and socioeconomic predictors of Asian Americans who work in small businesses to identify subgroups at a greater disadvantage than others in obtaining health insurance. Logistic regression models were fitted using a sample of 3,819 Asian American small business owners and employers extracted from pooled 2005–2012 California Health Interview Survey data. We found that individuals with low income levels, Korean Americans, U.S.-born South Asian and Southeast Asian (other than Vietnamese) Americans, immigrants without citizenship (particularly those lacking a green card), and individuals with limited English proficiency had higher odds of lacking coverage. The odds of being uninsured did not differ between small business owners and employees. Based upon these key findings, we propose several strategies to expand coverage for Asian Americans working in small businesses and their most vulnerable subgroups.

  18. Tune the topology to create or destroy patterns

    NASA Astrophysics Data System (ADS)

    Asllani, Malbor; Carletti, Timoteo; Fanelli, Duccio

    2016-12-01

    We consider the dynamics of a reaction-diffusion system on a multigraph. The species share the same set of nodes but can access different links to explore the embedding spatial support. By acting on the topology of the networks we can control the ability of the system to self-organise in macroscopic patterns, emerging as a symmetry breaking instability of an homogeneous fixed point. Two different cases study are considered: on the one side, we produce a global modification of the networks, starting from the limiting setting where species are hosted on the same graph. On the other, we consider the effect of inserting just one additional single link to differentiate the two graphs. In both cases, patterns can be generated or destroyed, as follows the imposed, small, topological perturbation. Approximate analytical formulae allow to grasp the essence of the phenomenon and can potentially inspire innovative control strategies to shape the macroscopic dynamics on multigraph networks.

  19. Topological strings in d < 1

    NASA Astrophysics Data System (ADS)

    Dijkgraaf, Robbert; Verlinde, Herman; Verlinde, Erik

    1991-03-01

    We calculate correlation functions in minimal topological field theories. These twisted versions of N = 2 minimal models have recently been proposed to describe d < 1 matrix models, once coupled to topological gravity. In our calculation we make use of the Landau-Ginzburg formulation of the N = 2 models, and we find a direct relation between the Landau-Ginzburg superpotential and the KdV differential operator. Using this correspondence we show that the minimal topological models are in perfect agreement with the matrix models as solved in terms of the KdV hierarchy. This proves the equivalence at tree-level of topological and ordinary string thoery in d < 1.

  20. Disrupted topological organization in whole-brain functional networks of heroin-dependent individuals: a resting-state FMRI study.

    PubMed

    Jiang, Guihua; Wen, Xue; Qiu, Yingwei; Zhang, Ruibin; Wang, Junjing; Li, Meng; Ma, Xiaofen; Tian, Junzhang; Huang, Ruiwang

    2013-01-01

    Neuroimaging studies have shown that heroin addiction is related to abnormalities in widespread local regions and in the functional connectivity of the brain. However, little is known about whether heroin addiction changes the topological organization of whole-brain functional networks. Seventeen heroin-dependent individuals (HDIs) and 15 age-, gender-matched normal controls (NCs) were enrolled, and the resting-state functional magnetic resonance images (RS-fMRI) were acquired from these subjects. We constructed the brain functional networks of HDIs and NCs, and compared the between-group differences in network topological properties using graph theory method. We found that the HDIs showed decreases in the normalized clustering coefficient and in small-worldness compared to the NCs. Furthermore, the HDIs exhibited significantly decreased nodal centralities primarily in regions of cognitive control network, including the bilateral middle cingulate gyrus, left middle frontal gyrus, and right precuneus, but significantly increased nodal centralities primarily in the left hippocampus. The between-group differences in nodal centralities were not corrected by multiple comparisons suggesting these should be considered as an exploratory analysis. Moreover, nodal centralities in the left hippocampus were positively correlated with the duration of heroin addiction. Overall, our results indicated that disruptions occur in the whole-brain functional networks of HDIs, findings which may be helpful in further understanding the mechanisms underlying heroin addiction.

  1. Noncommuting Momenta of Topological Solitons

    NASA Astrophysics Data System (ADS)

    Watanabe, Haruki; Murayama, Hitoshi

    2014-05-01

    We show that momentum operators of a topological soliton may not commute among themselves when the soliton is associated with the second cohomology H2 of the target space. The commutation relation is proportional to the winding number, taking a constant value within each topological sector. The noncommutativity makes it impossible to specify the momentum of a topological soliton, and induces a Magnus force.

  2. A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

    PubMed Central

    Chan, Leo L.; Lidstone, Erich A.; Finch, Kristin E.; Heeres, James T.; Hergenrother, Paul J.; Cunningham, Brian T.

    2010-01-01

    Small molecules identified through high-throughput screens are an essential element in pharmaceutical discovery programs. It is now recognized that a substantial fraction of small molecules exhibit aggregating behavior leading to false positive results in many screening assays, typically due to nonspecific attachment to target proteins. Therefore, the ability to efficiently identify compounds within a screening library that aggregate can streamline the screening process by eliminating unsuitable molecules from further consideration. In this work, we show that photonic crystal (PC) optical biosensor microplate technology can be used to identify and quantify small-molecule aggregation. A group of aggregators and nonaggregators were tested using the PC technology, and measurements were compared with those gathered by three alternative methods: dynamic light scattering (DLS), an α-chymotrypsin colorimetric assay, and scanning electron microscopy (SEM). The PC biosensor measurements of aggregation were confirmed by visual observation using SEM, and were in general agreement with the α-chymotrypsin assay. DLS measurements, in contrast, demonstrated inconsistent readings for many compounds that are found to form aggregates in shapes, very different from the classical spherical particles assumed in DLS modeling. As a label-free detection method, the PC biosensor aggregation assay is simple to implement and provides a quantitative direct measurement of the mass density of material adsorbed to the transducer surface, whereas the microplate-based sensor format enables compatibility with high-throughput automated liquid-handling methods used in pharmaceutical screening. PMID:20930952

  3. Electric field driven evolution of topological domain structure in hexagonal manganites

    NASA Astrophysics Data System (ADS)

    Yang, K. L.; Zhang, Y.; Zheng, S. H.; Lin, L.; Yan, Z. B.; Liu, J.-M.; Cheong, S.-W.

    2017-10-01

    Controlling and manipulating the topological state represents an important topic in condensed matters for both fundamental researches and applications. In this work, we focus on the evolution of a real-space topological domain structure in hexagonal manganites driven by electric field, using the analytical and numerical calculations based on the Ginzburg-Landau theory. It is revealed that the electric field drives a transition of the topological domain structure from the type-I pattern to the type-II one. In particular, it is identified that a high electric field can enforce the two antiphase-plus-ferroelectric (AP +FE ) domain walls with Δ Φ =π /3 to approach each other and to merge into one domain wall with Δ Φ = 2 π /3 eventually if the electric field is sufficiently high, where Δ Φ is the difference in the trimerization phase between two neighboring domains. Our simulations also reveal that the vortex cores of the topological structure can be disabled at a sufficiently high critical electric field by suppressing the structural trimerization therein, beyond which the vortex core region is replaced by a single ferroelectric domain without structural trimerization (Q = 0 ). Our results provide a stimulating reference for understanding the manipulation of real-space topological domain structure in hexagonal manganites.

  4. Experimentally probing topological order and its breakdown through modular matrices

    NASA Astrophysics Data System (ADS)

    Luo, Zhihuang; Li, Jun; Li, Zhaokai; Hung, Ling-Yan; Wan, Yidun; Peng, Xinhua; Du, Jiangfeng

    2018-02-01

    The modern concept of phases of matter has undergone tremendous developments since the first observation of topologically ordered states in fractional quantum Hall systems in the 1980s. In this paper, we explore the following question: in principle, how much detail of the physics of topological orders can be observed using state of the art technologies? We find that using surprisingly little data, namely the toric code Hamiltonian in the presence of generic disorders and detuning from its exactly solvable point, the modular matrices--characterizing anyonic statistics that are some of the most fundamental fingerprints of topological orders--can be reconstructed with very good accuracy solely by experimental means. This is an experimental realization of these fundamental signatures of a topological order, a test of their robustness against perturbations, and a proof of principle--that current technologies have attained the precision to identify phases of matter and, as such, probe an extended region of phase space around the soluble point before its breakdown. Given the special role of anyonic statistics in quantum computation, our work promises myriad applications both in probing and realistically harnessing these exotic phases of matter.

  5. The formation of topological defects in phase transitions

    NASA Technical Reports Server (NTRS)

    Hodges, Hardy M.

    1989-01-01

    It was argued, and fought through numerical work that the results of non-dynamical Monte Carlo computer simulations cannot be applied to describe the formation of topological defects when the correlation length at the Ginzburg temperature is significantly smaller than the horizon size. To test the current hypothesis that infinite strings at formation are essentially described by Brownian walks of size the correlation length at the Ginzburg temperature, fields at the Ginzburg temperature were equilibrated. Infinite structure do not exist in equilibrium for reasonable definitions of the Ginzburg temperature, and horizons must be included in a proper treatment. A phase transition, from small-scale to large-scale string or domain wall structure, is found to occur very close to the Ginzburg temperature, in agreement with recent work. The formation process of domain walls and global strings were investigated through the breaking of initially ordered states. To mimic conditions in the early Universe, cooling times are chosen so that horizons exist in the sample volume when topological structure formation occurs. The classical fields are evolved in real-time by the numerical solution of Langevin equations of motion on a three dimensional spatial lattice. The results indicate that it is possible for most of the string energy to be in small loops, rather than in long strings, at formation.

  6. Topological Defects in Topological Insulators and Bound States at Topological Superconductor Vortices.

    PubMed

    Parente, Vincenzo; Campagnano, Gabriele; Giuliano, Domenico; Tagliacozzo, Arturo; Guinea, Francisco

    2014-03-04

    The scattering of Dirac electrons by topological defects could be one of the most relevant sources of resistance in graphene and at the boundary surfaces of a three-dimensional topological insulator (3D TI). In the long wavelength, continuous limit of the Dirac equation, the topological defect can be described as a distortion of the metric in curved space, which can be accounted for by a rotation of the Gamma matrices and by a spin connection inherited with the curvature. These features modify the scattering properties of the carriers. We discuss the self-energy of defect formation with this approach and the electron cross-section for intra-valley scattering at an edge dislocation in graphene, including corrections coming from the local stress. The cross-section contribution to the resistivity, ρ, is derived within the Boltzmann theory of transport. On the same lines, we discuss the scattering of a screw dislocation in a two-band 3D TI, like Bi 1-x Sb x , and we present the analytical simplified form of the wavefunction for gapless helical states bound at the defect. When a 3D TI is sandwiched between two even-parity superconductors, Dirac boundary states acquire superconductive correlations by proximity. In the presence of a magnetic vortex piercing the heterostructure, two Majorana states are localized at the two interfaces and bound to the vortex core. They have a half integer total angular momentum each, to match with the unitary orbital angular momentum of the vortex charge.

  7. Proton spin: A topological invariant

    NASA Astrophysics Data System (ADS)

    Tiwari, S. C.

    2016-11-01

    Proton spin problem is given a new perspective with the proposition that spin is a topological invariant represented by a de Rham 3-period. The idea is developed generalizing Finkelstein-Rubinstein theory for Skyrmions/kinks to topological defects, and using non-Abelian de Rham theorems. Two kinds of de Rham theorems are discussed applicable to matrix-valued differential forms, and traces. Physical and mathematical interpretations of de Rham periods are presented. It is suggested that Wilson lines and loop operators probe the local properties of the topology, and spin as a topological invariant in pDIS measurements could appear with any value from 0 to ℏ 2, i.e. proton spin decomposition has no meaning in this approach.

  8. A topological quantum optics interface

    NASA Astrophysics Data System (ADS)

    Barik, Sabyasachi; Karasahin, Aziz; Flower, Christopher; Cai, Tao; Miyake, Hirokazu; DeGottardi, Wade; Hafezi, Mohammad; Waks, Edo

    2018-02-01

    The application of topology in optics has led to a new paradigm in developing photonic devices with robust properties against disorder. Although considerable progress on topological phenomena has been achieved in the classical domain, the realization of strong light-matter coupling in the quantum domain remains unexplored. We demonstrate a strong interface between single quantum emitters and topological photonic states. Our approach creates robust counterpropagating edge states at the boundary of two distinct topological photonic crystals. We demonstrate the chiral emission of a quantum emitter into these modes and establish their robustness against sharp bends. This approach may enable the development of quantum optics devices with built-in protection, with potential applications in quantum simulation and sensing.

  9. Reduced small world brain connectivity in probands with a family history of epilepsy.

    PubMed

    Bharath, R D; Chaitanya, G; Panda, R; Raghavendra, K; Sinha, S; Sahoo, A; Gohel, S; Biswal, B B; Satishchandra, P

    2016-12-01

    The role of inheritance in ascertaining susceptibility to epilepsy is well established, although the pathogenetic mechanisms are still not very clear. Interviewing for a positive family history is a popular epidemiological tool in the understanding of this susceptibility. Our aim was to visualize and localize network abnormalities that could be associated with a positive family history in a group of patients with hot water epilepsy (HWE) using resting-state functional magnetic resonance imaging (rsfMRI). Graph theory analysis of rsfMRI (clustering coefficient γ; path length λ; small worldness σ) in probands with a positive family history of epilepsy (FHE+, 25) were compared with probands without FHE (FHE-, 33). Whether a closer biological relationship was associated with a higher likelihood of network abnormalities was also ascertained. A positive family history of epilepsy had decreased γ, increased λ and decreased σ in bilateral temporofrontal regions compared to FHE- (false discovery rate corrected P ≤ 0.0062). These changes were more pronounced in probands having first degree relatives and siblings with epilepsy. Probands with multiple types of epilepsy in the family showed decreased σ in comparison to only HWE in the family. Graph theory analysis of the rsfMRI can be used to understand the neurobiology of diseases like genetic susceptibility in HWE. Reduced small worldness, proportional to the degree of relationship, is consistent with the current understanding that disease severity is higher in closer biological relations. © 2016 EAN.

  10. Fuzzy topological digital space and their properties of flat electroencephalography in epilepsy disease

    NASA Astrophysics Data System (ADS)

    Muzafar Shah, Mazlina; Fatah Wahab, Abdul

    2017-09-01

    There are an abnormal electric activities or irregular interference in brain of epilepsy patient. Then a sensor will be put in patient’s scalp to measure and records all electric activities in brain. The result of the records known as Electroencephalography (EEG). The EEG has been transfer to flat EEG because it’s easier to analyze. In this study, the uncertainty in flat EEG data will be considered as fuzzy digital space. The purpose of this research is to show that the flat EEG is fuzzy topological digital space. Therefore, the main focus for this research is to introduce fuzzy topological digital space concepts with their properties such as neighbourhood, interior and closure by using fuzzy set digital concept and Chang’s fuzzy topology approach. The product fuzzy topology digital also will be shown. By introduce this concept, the data in flat EEG can considering having fuzzy topology digital properties and can identify the area in fuzzy digital space that has been affected by epilepsy seizure in epileptic patient’s brain.

  11. Persistent topological features of dynamical systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maletić, Slobodan, E-mail: slobodan@hitsz.edu.cn; Institute of Nuclear Sciences Vinča, University of Belgrade, Belgrade; Zhao, Yi, E-mail: zhao.yi@hitsz.edu.cn

    Inspired by an early work of Muldoon et al., Physica D 65, 1–16 (1993), we present a general method for constructing simplicial complex from observed time series of dynamical systems based on the delay coordinate reconstruction procedure. The obtained simplicial complex preserves all pertinent topological features of the reconstructed phase space, and it may be analyzed from topological, combinatorial, and algebraic aspects. In focus of this study is the computation of homology of the invariant set of some well known dynamical systems that display chaotic behavior. Persistent homology of simplicial complex and its relationship with the embedding dimensions are examinedmore » by studying the lifetime of topological features and topological noise. The consistency of topological properties for different dynamic regimes and embedding dimensions is examined. The obtained results shed new light on the topological properties of the reconstructed phase space and open up new possibilities for application of advanced topological methods. The method presented here may be used as a generic method for constructing simplicial complex from a scalar time series that has a number of advantages compared to the mapping of the same time series to a complex network.« less

  12. Observation of long-lived persistent spin polarization in a topological insulator

    NASA Astrophysics Data System (ADS)

    Tian, Jifa; Hong, Seokmin; Miotkowski, Ireneusz; Datta, Supriyo; Chen, Yong P.

    3D Topological insulators (TI), featuring helically spin-momentum-locked topological surface states (TSS), are considered promising for spintronics applications. Several recent experiments in TIs have demonstrated a current induced electronic spin polarization that may be used for all electrical spin generation and injection. Here, we report spin potentiometric measurements in TIs that have revealed a long-lived persistent electron spin polarization even at zero current. Unaffected by a small bias current and persisting for several days at low temperature, the spin polarization can be induced and reversed by a large ``writing'' current applied for an extended time. Such an electrically controlled persistent spin polarization with unprecedented long lifetime could enable a rechargeable spin battery and rewritable spin memory for potential applications in spintronics and quantum information.

  13. Soft connectedness of soft topological space

    NASA Astrophysics Data System (ADS)

    Mishra, Sanjay

    2017-07-01

    Recently, Shabir and Naz in [4] introduced the notion of Soft Topological Spaces (STS). They defined and studied about soft topology on the collection τ of soft sets over X. After the initiation of soft topological space many researcher developed its basic theory as like soft continuity, soft compactness and soft countability. Our main objective in this paper is to study the soft connectedness properties of soft topological space and also establish relations of soft connectedness with other properties of STS.

  14. Topological Photonics for Continuous Media

    NASA Astrophysics Data System (ADS)

    Silveirinha, Mario

    Photonic crystals have revolutionized light-based technologies during the last three decades. Notably, it was recently discovered that the light propagation in photonic crystals may depend on some topological characteristics determined by the manner how the light states are mutually entangled. The usual topological classification of photonic crystals explores the fact that these structures are periodic. The periodicity is essential to ensure that the underlying wave vector space is a closed surface with no boundary. In this talk, we prove that it is possible calculate Chern invariants for a wide class of continuous bianisotropic electromagnetic media with no intrinsic periodicity. The nontrivial topology of the relevant continuous materials is linked with the emergence of edge states. Moreover, we will demonstrate that continuous photonic media with the time-reversal symmetry can be topologically characterized by a Z2 integer. This novel classification extends for the first time the theory of electronic topological insulators to a wide range of photonic platforms, and is expected to have an impact in the design of novel photonic systems that enable a topologically protected transport of optical energy. This work is supported in part by Fundacao para a Ciencia e a Tecnologia Grant Number PTDC/EEI-TEL/4543/2014.

  15. Topological materials discovery using electron filling constraints

    NASA Astrophysics Data System (ADS)

    Chen, Ru; Po, Hoi Chun; Neaton, Jeffrey B.; Vishwanath, Ashvin

    2018-01-01

    Nodal semimetals are classes of topological materials that have nodal-point or nodal-line Fermi surfaces, which give them novel transport and topological properties. Despite being highly sought after, there are currently very few experimental realizations, and identifying new materials candidates has mainly relied on exhaustive database searches. Here we show how recent studies on the interplay between electron filling and nonsymmorphic space-group symmetries can guide the search for filling-enforced nodal semimetals. We recast the previously derived constraints on the allowed band-insulator fillings in any space group into a new form, which enables effective screening of materials candidates based solely on their space group, electron count in the formula unit, and multiplicity of the formula unit. This criterion greatly reduces the computation load for discovering topological materials in a database of previously synthesized compounds. As a demonstration, we focus on a few selected nonsymmorphic space groups which are predicted to host filling-enforced Dirac semimetals. Of the more than 30,000 entires listed, our filling criterion alone eliminates 96% of the entries before they are passed on for further analysis. We discover a handful of candidates from this guided search; among them, the monoclinic crystal Ca2Pt2Ga is particularly promising.

  16. Heterogeneity and nearest-neighbor coupling can explain small-worldness and wave properties in pancreatic islets

    NASA Astrophysics Data System (ADS)

    Cappon, Giacomo; Pedersen, Morten Gram

    2016-05-01

    Many multicellular systems consist of coupled cells that work as a syncytium. The pancreatic islet of Langerhans is a well-studied example of such a microorgan. The islets are responsible for secretion of glucose-regulating hormones, mainly glucagon and insulin, which are released in distinct pulses. In order to observe pulsatile insulin secretion from the β-cells within the islets, the cellular responses must be synchronized. It is now well established that gap junctions provide the electrical nearest-neighbor coupling that allows excitation waves to spread across islets to synchronize the β-cell population. Surprisingly, functional coupling analysis of calcium responses in β-cells shows small-world properties, i.e., a high degree of local coupling with a few long-range "short-cut" connections that reduce the average path-length greatly. Here, we investigate how such long-range functional coupling can appear as a result of heterogeneity, nearest-neighbor coupling, and wave propagation. Heterogeneity is also able to explain a set of experimentally observed synchronization and wave properties without introducing all-or-none cell coupling and percolation theory. Our theoretical results highlight how local biological coupling can give rise to functional small-world properties via heterogeneity and wave propagation.

  17. Distributed fault detection over sensor networks with Markovian switching topologies

    NASA Astrophysics Data System (ADS)

    Ge, Xiaohua; Han, Qing-Long

    2014-05-01

    This paper deals with the distributed fault detection for discrete-time Markov jump linear systems over sensor networks with Markovian switching topologies. The sensors are scatteredly deployed in the sensor field and the fault detectors are physically distributed via a communication network. The system dynamics changes and sensing topology variations are modeled by a discrete-time Markov chain with incomplete mode transition probabilities. Each of these sensor nodes firstly collects measurement outputs from its all underlying neighboring nodes, processes these data in accordance with the Markovian switching topologies, and then transmits the processed data to the remote fault detector node. Network-induced delays and accumulated data packet dropouts are incorporated in the data transmission between the sensor nodes and the distributed fault detector nodes through the communication network. To generate localized residual signals, mode-independent distributed fault detection filters are proposed. By means of the stochastic Lyapunov functional approach, the residual system performance analysis is carried out such that the overall residual system is stochastically stable and the error between each residual signal and the fault signal is made as small as possible. Furthermore, a sufficient condition on the existence of the mode-independent distributed fault detection filters is derived in the simultaneous presence of incomplete mode transition probabilities, Markovian switching topologies, network-induced delays, and accumulated data packed dropouts. Finally, a stirred-tank reactor system is given to show the effectiveness of the developed theoretical results.

  18. Calculating degree-based topological indices of dominating David derived networks

    NASA Astrophysics Data System (ADS)

    Ahmad, Muhammad Saeed; Nazeer, Waqas; Kang, Shin Min; Imran, Muhammad; Gao, Wei

    2017-12-01

    An important area of applied mathematics is the Chemical reaction network theory. The behavior of real world problems can be modeled by using this theory. Due to applications in theoretical chemistry and biochemistry, it has attracted researchers since its foundation. It also attracts pure mathematicians because it involves interesting mathematical structures. In this report, we compute newly defined topological indices, namely, Arithmetic-Geometric index (AG1 index), SK index, SK1 index, and SK2 index of the dominating David derived networks [1, 2, 3, 4, 5].

  19. MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features.

    PubMed

    Xu, Juan; Li, Chuan-Xing; Li, Yong-Sheng; Lv, Jun-Ying; Ma, Ye; Shao, Ting-Ting; Xu, Liang-De; Wang, Ying-Ying; Du, Lei; Zhang, Yun-Peng; Jiang, Wei; Li, Chun-Quan; Xiao, Yun; Li, Xia

    2011-02-01

    Synergistic regulations among multiple microRNAs (miRNAs) are important to understand the mechanisms of complex post-transcriptional regulations in humans. Complex diseases are affected by several miRNAs rather than a single miRNA. So, it is a challenge to identify miRNA synergism and thereby further determine miRNA functions at a system-wide level and investigate disease miRNA features in the miRNA-miRNA synergistic network from a new view. Here, we constructed a miRNA-miRNA functional synergistic network (MFSN) via co-regulating functional modules that have three features: common targets of corresponding miRNA pairs, enriched in the same gene ontology category and close proximity in the protein interaction network. Predicted miRNA synergism is validated by significantly high co-expression of functional modules and significantly negative regulation to functional modules. We found that the MFSN exhibits a scale free, small world and modular architecture. Furthermore, the topological features of disease miRNAs in the MFSN are distinct from non-disease miRNAs. They have more synergism, indicating their higher complexity of functions and are the global central cores of the MFSN. In addition, miRNAs associated with the same disease are close to each other. The structure of the MFSN and the features of disease miRNAs are validated to be robust using different miRNA target data sets.

  20. Time reversibility of quantum diffusion in small-world networks

    NASA Astrophysics Data System (ADS)

    Han, Sung-Guk; Kim, Beom Jun

    2012-02-01

    We study the time-reversal dynamics of a tight-binding electron in the Watts-Strogatz (WS) small-world networks. The localized initial wave packet at time t = 0 diffuses as time proceeds until the time-reversal operation, together with the momentum perturbation of the strength η, is made at the reversal time T. The time irreversibility is measured by I = |Π( t = 2 T) - Π( t = 0)|, where Π is the participation ratio gauging the extendedness of the wavefunction and for convenience, t is measured forward even after the time reversal. When η = 0, the time evolution after T makes the wavefunction at t = 2 T identical to the one at t = 0, and we find I = 0, implying a null irreversibility or a complete reversibility. On the other hand, as η is increased from zero, the reversibility becomes weaker, and we observe enhancement of the irreversibility. We find that I linearly increases with increasing η in the weakly-perturbed region, and that the irreversibility is much stronger in the WS network than in the local regular network.

  1. Robust transport signatures of topological superconductivity in topological insulator nanowires.

    PubMed

    de Juan, Fernando; Ilan, Roni; Bardarson, Jens H

    2014-09-05

    Finding a clear signature of topological superconductivity in transport experiments remains an outstanding challenge. In this work, we propose exploiting the unique properties of three-dimensional topological insulator nanowires to generate a normal-superconductor junction in the single-mode regime where an exactly quantized 2e2/h zero-bias conductance can be observed over a wide range of realistic system parameters. This is achieved by inducing superconductivity in half of the wire, which can be tuned at will from trivial to topological with a parallel magnetic field, while a perpendicular field is used to gap out the normal part, except for two spatially separated chiral channels. The combination of chiral mode transport and perfect Andreev reflection makes the measurement robust to moderate disorder, and the quantization of conductance survives to much higher temperatures than in tunnel junction experiments. Our proposal may be understood as a variant of a Majorana interferometer which is easily realizable in experiments.

  2. Enhanced Mechanical Performance of Bio-Inspired Hybrid Structures Utilising Topological Interlocking Geometry

    PubMed Central

    Djumas, Lee; Molotnikov, Andrey; Simon, George P.; Estrin, Yuri

    2016-01-01

    Structural composites inspired by nacre have emerged as prime exemplars for guiding materials design of fracture-resistant, rigid hybrid materials. The intricate microstructure of nacre, which combines a hard majority phase with a small fraction of a soft phase, achieves superior mechanical properties compared to its constituents and has generated much interest. However, replicating the hierarchical microstructure of nacre is very challenging, not to mention improving it. In this article, we propose to alter the geometry of the hard building blocks by introducing the concept of topological interlocking. This design principle has previously been shown to provide an inherently brittle material with a remarkable flexural compliance. We now demonstrate that by combining the basic architecture of nacre with topological interlocking of discrete hard building blocks, hybrid materials of a new type can be produced. By adding a soft phase at the interfaces between topologically interlocked blocks in a single-build additive manufacturing process, further improvement of mechanical properties is achieved. The design of these fabricated hybrid structures has been guided by computational work elucidating the effect of various geometries. To our knowledge, this is the first reported study that combines the advantages of nacre-inspired structures with the benefits of topological interlocking. PMID:27216277

  3. Enhanced Mechanical Performance of Bio-Inspired Hybrid Structures Utilising Topological Interlocking Geometry.

    PubMed

    Djumas, Lee; Molotnikov, Andrey; Simon, George P; Estrin, Yuri

    2016-05-24

    Structural composites inspired by nacre have emerged as prime exemplars for guiding materials design of fracture-resistant, rigid hybrid materials. The intricate microstructure of nacre, which combines a hard majority phase with a small fraction of a soft phase, achieves superior mechanical properties compared to its constituents and has generated much interest. However, replicating the hierarchical microstructure of nacre is very challenging, not to mention improving it. In this article, we propose to alter the geometry of the hard building blocks by introducing the concept of topological interlocking. This design principle has previously been shown to provide an inherently brittle material with a remarkable flexural compliance. We now demonstrate that by combining the basic architecture of nacre with topological interlocking of discrete hard building blocks, hybrid materials of a new type can be produced. By adding a soft phase at the interfaces between topologically interlocked blocks in a single-build additive manufacturing process, further improvement of mechanical properties is achieved. The design of these fabricated hybrid structures has been guided by computational work elucidating the effect of various geometries. To our knowledge, this is the first reported study that combines the advantages of nacre-inspired structures with the benefits of topological interlocking.

  4. Photoinduced topological phase transition and spin polarization in a two-dimensional topological insulator

    NASA Astrophysics Data System (ADS)

    Chen, M. N.; Su, W.; Deng, M. X.; Ruan, Jiawei; Luo, W.; Shao, D. X.; Sheng, L.; Xing, D. Y.

    2016-11-01

    A great deal of attention has been paid to the topological phases engineered by photonics over the past few years. Here, we propose a topological quantum phase transition to a quantum anomalous Hall (QAH) phase induced by off-resonant circularly polarized light in a two-dimensional system that is initially in a quantum spin Hall phase or a trivial insulator phase. This provides an alternative method to realize the QAH effect, other than magnetic doping. The circularly polarized light effectively creates a Zeeman exchange field and a renormalized Dirac mass, which are tunable by varying the intensity of the light and drive the quantum phase transition. Both the transverse and longitudinal Hall conductivities are studied, and the former is consistent with the topological phase transition when the Fermi level lies in the band gap. A highly controllable spin-polarized longitudinal electrical current can be generated when the Fermi level is in the conduction band, which may be useful for designing topological spintronics.

  5. Topological superconductivity in an ultrathin, magnetically-doped topological insulator proximity coupled to a conventional superconductor

    NASA Astrophysics Data System (ADS)

    Kim, Youngseok; Philip, Timothy M.; Park, Moon Jip; Gilbert, Matthew J.; University of Illinois at Urbana; Champaign Team

    As a promising candidate system to realize topological superconductivity (SC), 3D time-reversal invariant topological insulators (TI) proximity-coupled to s-wave superconductors have been intensively studied. Recent experiments on proximity-coupled TI have shown that superconductivity may be induced in ultrathin TI. One proposal to observe the topological SC in proximity-coupled ultrathin TI system is to add magnetic dopants to the TI. However, detailed study on the impact of the experimental parameters on possible topological phase is sparse. In this work, we investigate ultrathin, magnetically-doped, proximity-coupled TI in order to determine the experimentally relevant parameters needed to observe topological SC. We find that, due to the spin-momentum locked nature of the surface states in TI, the induced s-wave order parameter within the surface states persists even at large magnitudes of the Zeeman energy, allowing us to explore the system in parameter space. We elucidate the phase diagram as a function of: the hybridization gap, Zeeman energy, and chemical potential of the TI system. Our findings provide a useful guide in choosing relevant parameters to facilitate the observation of topological SC in thin film TI-superconductor hybrid systems. National Science Foundation (NSF) under Grant CAREER ECCS-1351871.

  6. General covariance, topological quantum field theories and fractional statistics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gamboa, J.

    1992-01-20

    Topological quantum field theories and fractional statistics are both defined in multiply connected manifolds. The authors study the relationship between both theories in 2 + 1 dimensions and the authors show that, due to the multiply-connected character of the manifold, the propagator for any quantum (field) theory always contains a first order pole that can be identified with a physical excitation with fractional spin. The article starts by reviewing the definition of general covariance in the Hamiltonian formalism, the gauge-fixing problem and the quantization following the lines of Batalin, Fradkin and Vilkovisky. The BRST-BFV quantization is reviewed in order tomore » understand the topological approach proposed here.« less

  7. Rapid identifying high-influence nodes in complex networks

    NASA Astrophysics Data System (ADS)

    Song, Bo; Jiang, Guo-Ping; Song, Yu-Rong; Xia, Ling-Ling

    2015-10-01

    A tiny fraction of influential individuals play a critical role in the dynamics on complex systems. Identifying the influential nodes in complex networks has theoretical and practical significance. Considering the uncertainties of network scale and topology, and the timeliness of dynamic behaviors in real networks, we propose a rapid identifying method (RIM) to find the fraction of high-influential nodes. Instead of ranking all nodes, our method only aims at ranking a small number of nodes in network. We set the high-influential nodes as initial spreaders, and evaluate the performance of RIM by the susceptible-infected-recovered (SIR) model. The simulations show that in different networks, RIM performs well on rapid identifying high-influential nodes, which is verified by typical ranking methods, such as degree, closeness, betweenness, and eigenvector centrality methods. Project supported by the National Natural Science Foundation of China (Grant Nos. 61374180 and 61373136), the Ministry of Education Research in the Humanities and Social Sciences Planning Fund Project, China (Grant No. 12YJAZH120), and the Six Projects Sponsoring Talent Summits of Jiangsu Province, China (Grant No. RLD201212).

  8. A geospatial assessment of mini/small hydropower potential in Sub-Saharan Africa

    NASA Astrophysics Data System (ADS)

    Korkovelos, Alexandros; Mentis, Dimitrios; Hussain Siyal, Shahid; Arderne, Christopher; Beck, Hylke; de Roo, Ad; Howells, Mark

    2017-04-01

    Sub-Saharan Africa has been the epicenter of ongoing global dialogues around energy poverty and justifiably so. More than half of the world's unserved population lives there. At the same time, a big part of the continent is privileged with plentiful renewable energy resources. Hydropower is one of them and to a large extent it remains untapped. This study focuses on the technical assessment of small-scale hydropower (0.01-10 MW) in Sub-Saharan Africa. The underlying methodology was based on open source geospatial datasets, whose combination allowed a consistent evaluation of 712,615 km of river network spanning over 44 countries. Environmental, topological and social constraints were included in the form of geospatial restrictions to help preserve the natural wealth and promote sustainable development. The results revealed that small-scale hydropower could cover 8.5-12.5% of the estimated electricity demand in 2030, thus making it a viable option to support electrification efforts in the region.

  9. Mechanical topological insulator in zero dimensions

    NASA Astrophysics Data System (ADS)

    Lera, Natalia; Alvarez, J. V.

    2018-04-01

    We study linear vibrational modes in finite isostatic Maxwell lattices, mechanical systems where the number of degrees of freedom matches the number of constraints. Recent progress in topological mechanics exploits the nontrivial topology of BDI class Hamiltonians in one dimenson and arising topological floppy modes at the edges. A finite frame, or zero-dimensional system, also exhibits a nonzero topological index according to the classification table. We construct mechanical insulating models in zero dimensions that complete the BDI classification in the available real space dimensions. We compute and interpret its nontrivial invariant Z2.

  10. Topology optimization of pressure adaptive honeycomb for a morphing flap

    NASA Astrophysics Data System (ADS)

    Vos, Roelof; Scheepstra, Jan; Barrett, Ron

    2011-03-01

    The paper begins with a brief historical overview of pressure adaptive materials and structures. By examining avian anatomy, it is seen that pressure-adaptive structures have been used successfully in the Natural world to hold structural positions for extended periods of time and yet allow for dynamic shape changes from one flight state to the next. More modern pneumatic actuators, including FAA certified autopilot servoactuators are frequently used by aircraft around the world. Pneumatic artificial muscles (PAM) show good promise as aircraft actuators, but follow the traditional model of load concentration and distribution commonly found in aircraft. A new system is proposed which leaves distributed loads distributed and manipulates structures through a distributed actuator. By using Pressure Adaptive Honeycomb (PAH), it is shown that large structural deformations in excess of 50% strains can be achieved while maintaining full structural integrity and enabling secondary flight control mechanisms like flaps. The successful implementation of pressure-adaptive honeycomb in the trailing edge of a wing section sparked the motivation for subsequent research into the optimal topology of the pressure adaptive honeycomb within the trailing edge of a morphing flap. As an input for the optimization two known shapes are required: a desired shape in cruise configuration and a desired shape in landing configuration. In addition, the boundary conditions and load cases (including aerodynamic loads and internal pressure loads) should be specified for each condition. Finally, a set of six design variables is specified relating to the honeycomb and upper skin topology of the morphing flap. A finite-element model of the pressure-adaptive honeycomb structure is developed specifically tailored to generate fast but reliable results for a given combination of external loading, input variables, and boundary conditions. Based on two bench tests it is shown that this model correlates well

  11. Naming games in two-dimensional and small-world-connected random geometric networks.

    PubMed

    Lu, Qiming; Korniss, G; Szymanski, B K

    2008-01-01

    We investigate a prototypical agent-based model, the naming game, on two-dimensional random geometric networks. The naming game [Baronchelli, J. Stat. Mech.: Theory Exp. (2006) P06014] is a minimal model, employing local communications that captures the emergence of shared communication schemes (languages) in a population of autonomous semiotic agents. Implementing the naming games with local broadcasts on random geometric graphs, serves as a model for agreement dynamics in large-scale, autonomously operating wireless sensor networks. Further, it captures essential features of the scaling properties of the agreement process for spatially embedded autonomous agents. Among the relevant observables capturing the temporal properties of the agreement process, we investigate the cluster-size distribution and the distribution of the agreement times, both exhibiting dynamic scaling. We also present results for the case when a small density of long-range communication links are added on top of the random geometric graph, resulting in a "small-world"-like network and yielding a significantly reduced time to reach global agreement. We construct a finite-size scaling analysis for the agreement times in this case.

  12. Resilient Wireless Sensor Networks Using Topology Control: A Review

    PubMed Central

    Huang, Yuanjiang; Martínez, José-Fernán; Sendra, Juana; López, Lourdes

    2015-01-01

    Wireless sensor networks (WSNs) may be deployed in failure-prone environments, and WSNs nodes easily fail due to unreliable wireless connections, malicious attacks and resource-constrained features. Nevertheless, if WSNs can tolerate at most losing k − 1 nodes while the rest of nodes remain connected, the network is called k − connected. k is one of the most important indicators for WSNs’ self-healing capability. Following a WSN design flow, this paper surveys resilience issues from the topology control and multi-path routing point of view. This paper provides a discussion on transmission and failure models, which have an important impact on research results. Afterwards, this paper reviews theoretical results and representative topology control approaches to guarantee WSNs to be k − connected at three different network deployment stages: pre-deployment, post-deployment and re-deployment. Multi-path routing protocols are discussed, and many NP-complete or NP-hard problems regarding topology control are identified. The challenging open issues are discussed at the end. This paper can serve as a guideline to design resilient WSNs. PMID:26404272

  13. Topological interface modes in graphene multilayer arrays

    NASA Astrophysics Data System (ADS)

    Wang, Feng; Ke, Shaolin; Qin, Chengzhi; Wang, Bing; Long, Hua; Wang, Kai; Lu, Peixiang

    2018-07-01

    We investigate the topological interface modes of surface plasmon polaritons in a multilayer system composed of graphene waveguide arrays. The topological interface modes emerge when two topologically distinct graphene multilayer arrays are connected. In such multilayer system, the non-trivial topological interface modes and trivial modes coexist. By tuning the configuration of the graphene multilayer arrays, the associated non-trivial interface modes present robust against structural disorder. The total number of topological modes is related to that of graphene layers in a unit cell of the graphene multilayer array. The results provide a new paradigm for topologically protected plasmonics in the graphene multilayer arrays. The study suggests a promising approach to realize light transport and optical switching on a deep-subwavelength scale.

  14. Topological Defects in Topological Insulators and Bound States at Topological Superconductor Vortices

    PubMed Central

    Parente, Vincenzo; Campagnano, Gabriele; Giuliano, Domenico; Tagliacozzo, Arturo; Guinea, Francisco

    2014-01-01

    The scattering of Dirac electrons by topological defects could be one of the most relevant sources of resistance in graphene and at the boundary surfaces of a three-dimensional topological insulator (3D TI). In the long wavelength, continuous limit of the Dirac equation, the topological defect can be described as a distortion of the metric in curved space, which can be accounted for by a rotation of the Gamma matrices and by a spin connection inherited with the curvature. These features modify the scattering properties of the carriers. We discuss the self-energy of defect formation with this approach and the electron cross-section for intra-valley scattering at an edge dislocation in graphene, including corrections coming from the local stress. The cross-section contribution to the resistivity, ρ, is derived within the Boltzmann theory of transport. On the same lines, we discuss the scattering of a screw dislocation in a two-band 3D TI, like Bi1−xSbx, and we present the analytical simplified form of the wavefunction for gapless helical states bound at the defect. When a 3D TI is sandwiched between two even-parity superconductors, Dirac boundary states acquire superconductive correlations by proximity. In the presence of a magnetic vortex piercing the heterostructure, two Majorana states are localized at the two interfaces and bound to the vortex core. They have a half integer total angular momentum each, to match with the unitary orbital angular momentum of the vortex charge. PMID:28788537

  15. Topological Vulnerability Analysis

    NASA Astrophysics Data System (ADS)

    Jajodia, Sushil; Noel, Steven

    Traditionally, network administrators rely on labor-intensive processes for tracking network configurations and vulnerabilities. This requires a great deal of expertise, and is error prone because of the complexity of networks and associated security data. The interdependencies of network vulnerabilities make traditional point-wise vulnerability analysis inadequate. We describe a Topological Vulnerability Analysis (TVA) approach that analyzes vulnerability dependencies and shows all possible attack paths into a network. From models of the network vulnerabilities and potential attacker exploits, we compute attack graphs that convey the impact of individual and combined vulnerabilities on overall security. TVA finds potential paths of vulnerability through a network, showing exactly how attackers may penetrate a network. From this, we identify key vulnerabilities and provide strategies for protection of critical network assets.

  16. Expediting topology data gathering for the TOPDB database.

    PubMed

    Dobson, László; Langó, Tamás; Reményi, István; Tusnády, Gábor E

    2015-01-01

    The Topology Data Bank of Transmembrane Proteins (TOPDB, http://topdb.enzim.ttk.mta.hu) contains experimentally determined topology data of transmembrane proteins. Recently, we have updated TOPDB from several sources and utilized a newly developed topology prediction algorithm to determine the most reliable topology using the results of experiments as constraints. In addition to collecting the experimentally determined topology data published in the last couple of years, we gathered topographies defined by the TMDET algorithm using 3D structures from the PDBTM. Results of global topology analysis of various organisms as well as topology data generated by high throughput techniques, like the sequential positions of N- or O-glycosylations were incorporated into the TOPDB database. Moreover, a new algorithm was developed to integrate scattered topology data from various publicly available databases and a new method was introduced to measure the reliability of predicted topologies. We show that reliability values highly correlate with the per protein topology accuracy of the utilized prediction method. Altogether, more than 52,000 new topology data and more than 2600 new transmembrane proteins have been collected since the last public release of the TOPDB database. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. The topology of metabolic isotope labeling networks.

    PubMed

    Weitzel, Michael; Wiechert, Wolfgang; Nöh, Katharina

    2007-08-29

    Metabolic Flux Analysis (MFA) based on isotope labeling experiments (ILEs) is a widely established tool for determining fluxes in metabolic pathways. Isotope labeling networks (ILNs) contain all essential information required to describe the flow of labeled material in an ILE. Whereas recent experimental progress paves the way for high-throughput MFA, large network investigations and exact statistical methods, these developments are still limited by the poor performance of computational routines used for the evaluation and design of ILEs. In this context, the global analysis of ILN topology turns out to be a clue for realizing large speedup factors in all required computational procedures. With a strong focus on the speedup of algorithms the topology of ILNs is investigated using graph theoretic concepts and algorithms. A rigorous determination of all cyclic and isomorphic subnetworks, accompanied by the global analysis of ILN connectivity is performed. Particularly, it is proven that ILNs always brake up into a large number of small strongly connected components (SCCs) and, moreover, there are natural isomorphisms between many of these SCCs. All presented techniques are universal, i.e. they do not require special assumptions on the network structure, bidirectionality of fluxes, measurement configuration, or label input. The general results are exemplified with a practically relevant metabolic network which describes the central metabolism of E. coli comprising 10390 isotopomer pools. Exploiting the topological features of ILNs leads to a significant speedup of all universal algorithms for ILE evaluation. It is proven in theory and exemplified with the E. coli example that a speedup factor of about 1000 compared to standard algorithms is achieved. This widely opens the door for new high performance algorithms suitable for high throughput applications and large ILNs. Moreover, for the first time the global topological analysis of ILNs allows to comprehensively

  18. Continuity and Separation in Symmetric Topologies

    ERIC Educational Resources Information Center

    Harris, J.; Lynch, M.

    2007-01-01

    In this note, it is shown that in a symmetric topological space, the pairs of sets separated by the topology determine the topology itself. It is then shown that when the codomain is symmetric, functions which separate only those pairs of sets that are already separated are continuous, generalizing a result found by M. Lynch.

  19. Chemical disorder in topological insulators: A route to magnetism tolerant topological surface states

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martínez-Velarte, M. Carmen; Kretz, Bernhard; Moro-Lagares, Maria

    Here, we show that the chemical inhomogeneity in ternary three-dimensional topological insulators preserves the topological spin texture of their surface states against a net surface magnetization. The spin texture is that of a Dirac cone with helical spin structure in the reciprocal space, which gives rise to spin-polarized and dissipation-less charge currents. Thanks to the nontrivial topology of the bulk electronic structure, this spin texture is robust against most types of surface defects. However, magnetic perturbations break the time-reversal symmetry, enabling magnetic scattering and loss of spin coherence of the charge carriers. This intrinsic incompatibility precludes the design of magnetoelectronicmore » devices based on the coupling between magnetic materials and topological surface states. We demonstrate that the magnetization coming from individual Co atoms deposited on the surface can disrupt the spin coherence of the carriers in the archetypal topological insulator Bi 2Te 3, while in Bi 2Se 2Te the spin texture remains unperturbed. This is concluded from the observation of elastic backscattering events in quasiparticle interference patterns obtained by scanning tunneling spectroscopy. The mechanism responsible for the protection is investigated by energy resolved spectroscopy and ab initio calculations, and it is ascribed to the distorted adsorption geometry of localized magnetic moments due to Se–Te disorder, which suppresses the Co hybridization with the surface states.« less

  20. Chemical disorder in topological insulators: A route to magnetism tolerant topological surface states

    DOE PAGES

    Martínez-Velarte, M. Carmen; Kretz, Bernhard; Moro-Lagares, Maria; ...

    2017-06-13

    Here, we show that the chemical inhomogeneity in ternary three-dimensional topological insulators preserves the topological spin texture of their surface states against a net surface magnetization. The spin texture is that of a Dirac cone with helical spin structure in the reciprocal space, which gives rise to spin-polarized and dissipation-less charge currents. Thanks to the nontrivial topology of the bulk electronic structure, this spin texture is robust against most types of surface defects. However, magnetic perturbations break the time-reversal symmetry, enabling magnetic scattering and loss of spin coherence of the charge carriers. This intrinsic incompatibility precludes the design of magnetoelectronicmore » devices based on the coupling between magnetic materials and topological surface states. We demonstrate that the magnetization coming from individual Co atoms deposited on the surface can disrupt the spin coherence of the carriers in the archetypal topological insulator Bi 2Te 3, while in Bi 2Se 2Te the spin texture remains unperturbed. This is concluded from the observation of elastic backscattering events in quasiparticle interference patterns obtained by scanning tunneling spectroscopy. The mechanism responsible for the protection is investigated by energy resolved spectroscopy and ab initio calculations, and it is ascribed to the distorted adsorption geometry of localized magnetic moments due to Se–Te disorder, which suppresses the Co hybridization with the surface states.« less