A 10-Year Mechatronics Curriculum Development Initiative: Relevance, Content, and Results--Part II

ERIC Educational Resources Information Center

Krishnan, M.; Das, S.; Yost, S. A.

2010-01-01

This paper describes the second and third phases of a comprehensive mechatronics curriculum development effort. They encompass the development of two advanced mechatronics courses ("Simulation and Modeling of Mechatronic Systems" and "Sensors and Actuators for Mechatronic Systems"), the formulation of a Mechatronics concentration, and offshoot…

Wusor II: A Computer Aided Instruction Program with Student Modelling Capabilities. AI Memo 417.

ERIC Educational Resources Information Center

Carr, Brian

Wusor II is the second intelligent computer aided instruction (ICAI) program that has been developed to monitor the progress of, and offer suggestions to, students playing Wumpus, a computer game designed to teach logical thinking and problem solving. From the earlier efforts with Wusor I, it was possible to produce a rule-based expert which…

Sampling for Air Chemical Emissions from the Life Sciences Laboratory II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ballinger, Marcel Y.; Lindberg, Michael J.

Sampling for air chemical emissions from the Life Science Laboratory II (LSL-II) ventilation stack was performed in an effort to determine potential exposure of maintenance staff to laboratory exhaust on the building roof. The concern about worker exposure was raised in December 2015 and several activities were performed to assist in estimating exposure concentrations. Data quality objectives were developed to determine the need for and scope and parameters of a sampling campaign to measure chemical emissions from research and development activities to the outside air. The activities provided data on temporal variation of air chemical concentrations and a basis formore » evaluating calculated emissions. Sampling for air chemical emissions was performed in the LSL-II ventilation stack over the 6-week period from July 26 to September 1, 2016. A total of 12 sampling events were carried out using 16 sample media. Resulting analysis provided concentration data on 49 analytes. All results were below occupational exposure limits and most results were below detection limits. When compared to calculated emissions, only 5 of the 49 chemicals had measured concentrations greater than predicted. This sampling effort will inform other study components to develop a more complete picture of a worker’s potential exposure from LSL-II rooftop activities. Mixing studies were conducted to inform spatial variation in concentrations at other rooftop locations and can be used in conjunction with these results to provide temporal variations in concentrations for estimating the potential exposure to workers working in and around the LSL-II stack.« less

Nanomolar pyrophosphate detection and nucleus staining in living cells with simple terpyridine-Zn(II) complexes.

PubMed

Chao, Duobin; Ni, Shitan

2016-05-20

Great efforts have been made to develop fluorescent probes for pyrophosphate (PPi) detection. Nucleus staining with fluorescence microscopy has been also widely investigated. But fluorescent probes for PPi detection with high sensitivity in water medium and nucleus staining with low-cost non-precious metal complexes in living cells are still challenging. Herein, we report simple terpyridine-Zn(II) complexes for selective nanomolar PPi detection over ATP and ADP in water based on aggregation induced emission (AIE) and intramolecular charge transfer (ICT). In addition, these terpyridine-Zn(II) complexes were successfully employed for nucleus staining in living cells. These results demonstrated simply obtained terpyridine-Zn(II) complexes are powerful tool for PPi detection and the development of PPi-related studies.

Universal real-time highway information system development program : final report phase II.

DOT National Transportation Integrated Search

2009-01-01

The final phase of a two phase effort was undertaken to establish data forms and communication protocols to provide the New York State Department of Transportation access to the unique highway data resource, HIVIS developed in the initial phase of th...

HPC Access Using KVM over IP

DTIC Science & Technology

2007-06-08

Lightwave VDE /200 KVM-over-Fiber (Keyboard, Video and Mouse) devices installed throughout the TARDEC campus. Implementation of this system required...development effort through the pursuit of an Army-funded Phase-II Small Business Innovative Research (SBIR) effort with IP Video Systems (formerly known as...visualization capabilities of a DoD High- Performance Computing facility, many advanced features are necessary. TARDEC-HPC’s SBIR with IP Video Systems

Ask Pete, software planning and estimation through project characterization

NASA Technical Reports Server (NTRS)

Kurtz, T.

2001-01-01

Ask Pete, was developed by NASA to provide a tool for integrating the estimation and planning activities for a software development effort. It incorporates COCOMO II estimating with NASA's software development practices and IV&V criteria to characterize a project. This characterization is then used to generate estimates and tailored planning documents.

The Florida Educational Research and Development Program. Second Annual Report.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee.

This report describes the efforts being made through the Educational Research and Development Program to implement the new state strategy of reducing restrictions on local and institutional officials and at the same time holding them accountable for the effectiveness of their programs. Chapter II considers the development of techniques for…

Rural Development Research: A Foundation for Policy. Contributions in Economics and Economic History, Number 170.

ERIC Educational Resources Information Center

Rowley, Thomas D., Ed.; And Others

This book addresses the need for research information that can be used as a foundation for rural development policy. Part I deals with the four components of rural development: education (human capital), entrepreneurship, physical infrastructure, and social infrastructure. Part II examines analytic methods of measuring rural development efforts,…

76 FR 25723 - Proposed Information Collection for Growing America Through Entrepreneurship (GATE) II Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

... workforce and economic development. Project GATE was an experimental design demonstration that investigated... its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation... evaluated a demonstration program designed to assist individuals interested in self-employment to develop...

45 CFR 2516.500 - How does the Corporation review the merits of an application?

Code of Federal Regulations, 2011 CFR

2011-10-01

... and with other federally assisted activities; (ii) The program will foster collaborative efforts among... education reform and school-to-work transition; (7) Develop civic responsibility and leadership skills and...

45 CFR 2516.500 - How does the Corporation review the merits of an application?

Code of Federal Regulations, 2010 CFR

2010-10-01

... and with other federally assisted activities; (ii) The program will foster collaborative efforts among... education reform and school-to-work transition; (7) Develop civic responsibility and leadership skills and...

Toward a Mechanistic Source Term in Advanced Reactors: A Review of Past U.S. SFR Incidents, Experiments, and Analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bucknor, Matthew; Brunett, Acacia J.; Grabaskas, David

In 2015, as part of a Regulatory Technology Development Plan (RTDP) effort for sodium-cooled fast reactors (SFRs), Argonne National Laboratory investigated the current state of knowledge of source term development for a metal-fueled, pool-type SFR. This paper provides a summary of past domestic metal-fueled SFR incidents and experiments and highlights information relevant to source term estimations that were gathered as part of the RTDP effort. The incidents described in this paper include fuel pin failures at the Sodium Reactor Experiment (SRE) facility in July of 1959, the Fermi I meltdown that occurred in October of 1966, and the repeated meltingmore » of a fuel element within an experimental capsule at the Experimental Breeder Reactor II (EBR-II) from November 1967 to May 1968. The experiments described in this paper include the Run-Beyond-Cladding-Breach tests that were performed at EBR-II in 1985 and a series of severe transient overpower tests conducted at the Transient Reactor Test Facility (TREAT) in the mid-1980s.« less

HART-II: Prediction of Blade-Vortex Interaction Loading

NASA Technical Reports Server (NTRS)

Lim, Joon W.; Tung, Chee; Yu, Yung H.; Burley, Casey L.; Brooks, Thomas; Boyd, Doug; vanderWall, Berend; Schneider, Oliver; Richard, Hugues; Raffel, Markus

2003-01-01

During the HART-I data analysis, the need for comprehensive wake data was found including vortex creation and aging, and its re-development after blade-vortex interaction. In October 2001, US Army AFDD, NASA Langley, German DLR, French ONERA and Dutch DNW performed the HART-II test as an international joint effort. The main objective was to focus on rotor wake measurement using a PIV technique along with the comprehensive data of blade deflections, airloads, and acoustics. Three prediction teams made preliminary correlation efforts with HART-II data: a joint US team of US Army AFDD and NASA Langley, German DLR, and French ONERA. The predicted results showed significant improvements over the HART-I predicted results, computed about several years ago, which indicated that there has been better understanding of complicated wake modeling in the comprehensive rotorcraft analysis. All three teams demonstrated satisfactory prediction capabilities, in general, though there were slight deviations of prediction accuracies for various disciplines.

Subsonic Ultra Green Aircraft Research Phase II: N+4 Advanced Concept Development

NASA Technical Reports Server (NTRS)

Bradley, Marty K.; Droney, Christopher K.

2012-01-01

This final report documents the work of the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team on Task 1 of the Phase II effort. The team consisted of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, and Georgia Tech. Using a quantitative workshop process, the following technologies, appropriate to aircraft operational in the N+4 2040 timeframe, were identified: Liquefied Natural Gas (LNG), Hydrogen, fuel cell hybrids, battery electric hybrids, Low Energy Nuclear (LENR), boundary layer ingestion propulsion (BLI), unducted fans and advanced propellers, and combinations. Technology development plans were developed.

Launch Vehicle Ascent Trajectory Simulation Using the Program to Optimize Simulated Trajectories II (POST2)

NASA Technical Reports Server (NTRS)

Lugo, Rafael A.; Shidner, Jeremy D.; Powell, Richard W.; Marsh, Steven M.; Hoffman, James A.; Litton, Daniel K.; Schmitt, Terri L.

2017-01-01

The Program to Optimize Simulated Trajectories II (POST2) has been continuously developed for over 40 years and has been used in many flight and research projects. Recently, there has been an effort to improve the POST2 architecture by promoting modularity, flexibility, and ability to support multiple simultaneous projects. The purpose of this paper is to provide insight into the development of trajectory simulation in POST2 by describing methods and examples of various improved models for a launch vehicle liftoff and ascent.

Phase II: Automated System for Aneuploidy Detection in Sperm Final Report CRADA No. TC-1554-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wyrobek, W. J.; Dunlay, R. T.

This was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and Cellomics, Inc. (formerly BioDx and Biological Detection, Inc.) to develop an automated system for detecting human sperm aneuploidy. Aneuploidy (an abnormal number of chromosomes) is one of the major categories of chromosomally abnormal sperm, which results in chromosomally defective pregnancies and babies. An automated system would be used for testing the effects of toxic agents and for other research and clinical applications. This collaborated effort was funded by a National Institutes of Environmental Health Services, Phase II, Small Business Innovation Research Program (SBIR) grantmore » to Cellornics (Contract No. N44-ES-82004).« less

Detection of Instrumental Drifts in the PEP II LER BPM System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wittmer, W.; Fisher, A.S.; Martin, D.J.

2007-11-07

During the last PEP-II run a major goal was to bring the Low-Energy Ring optics as close as possible to the design. A large number of BPMs exhibited sudden artificial jumps that interfered with this effort. The source of the majority of these jumps had been traced to the filter-isolator boxes (FIBs) near the BPM buttons. A systematic approach to find and repair the failing units had been developed and implemented. Despite this effort, the instrumental orbit jumps never completely disappeared. To trace the source of this behavior a test setup, using a spare Bergoz MX-BPM processor (kindly provided bymore » SPEAR III at SSRL), was connected in parallel to various PEP-II BPM processors. In the course of these measurements a slow instrumental orbit drift was found which was clearly not induced by a moving positron beam. Based on the size of the system and the limited time before PEP-II closes in Oct.2008, an accelerator improvement project was initiated to install BERGOZ BPM-MX processors close to all sextupoles.« less

Enhanced chemical weapon warning via sensor fusion

NASA Astrophysics Data System (ADS)

Flaherty, Michael; Pritchett, Daniel; Cothren, Brian; Schwaiger, James

2011-05-01

Torch Technologies Inc., is actively involved in chemical sensor networking and data fusion via multi-year efforts with Dugway Proving Ground (DPG) and the Defense Threat Reduction Agency (DTRA). The objective of these efforts is to develop innovative concepts and advanced algorithms that enhance our national Chemical Warfare (CW) test and warning capabilities via the fusion of traditional and non-traditional CW sensor data. Under Phase I, II, and III Small Business Innovative Research (SBIR) contracts with DPG, Torch developed the Advanced Chemical Release Evaluation System (ACRES) software to support non real-time CW sensor data fusion. Under Phase I and II SBIRs with DTRA in conjunction with the Edgewood Chemical Biological Center (ECBC), Torch is using the DPG ACRES CW sensor data fuser as a framework from which to develop the Cloud state Estimation in a Networked Sensor Environment (CENSE) data fusion system. Torch is currently developing CENSE to implement and test innovative real-time sensor network based data fusion concepts using CW and non-CW ancillary sensor data to improve CW warning and detection in tactical scenarios.

Phase II Final Report on an Intelligent Tutoring System for Teaching Battlefield Command Reasoning Skills

DTIC Science & Technology

2004-03-01

and current work is that most developers see unstructured language input as a useful complement to a Socratic tutoring approach. The general...demonstrating the possibility of Socratic tactical tutoring, led us , during the second half of our Phase II effort, away from unrestricted natural language ... language use . This often leads to faster, more useful processing, that is robust in the face of real-world input (ungrammatical, misspelled, or

Amphibious Landing Operations in World War II: Personal Experience in Applying and Developing Doctrine

DTIC Science & Technology

2015-05-21

the forefront of the Army’s effort to gain experience planning and conducting amphibious landings was Lucian K . Truscott, Jr, a Cavalry officer by...Landing Operations, Lucian K . Truscott, Jr., Operation Torch, Operation Husky, 3rd Infantry Division, World War II 16. SECURITY CLASSIFICATION OF: 17...gain experience planning and conducting amphibious landings was Lucian K . Truscott, Jr., a Cavalry officer by training. Following his assignment to

Synthetic Teammates as Team Players: Coordination of Human and Synthetic Teammates

DTIC Science & Technology

2016-05-31

distribution is unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT This project is part of a larger effort that focuses on human-automation coordination in the...context of the development, integration, and validation of a computational cognitive model that acts as a full-fledged synthetic teammate on an...integrated the synthetic teammate model into the CERTT II (Cognitive Engineering Research on Team Tasks II) testbed in order to empirically address these

The Chancellor's Model School Project (CMSP)

NASA Technical Reports Server (NTRS)

Lopez, Gil

1999-01-01

What does it take to create and implement a 7th to 8th grade middle school program where the great majority of students achieve at high academic levels regardless of their previous elementary school backgrounds? This was the major question that guided the research and development of a 7-year long project effort entitled the Chancellor's Model School Project (CMSP) from September 1991 to August 1998. The CMSP effort conducted largely in two New York City public schools was aimed at creating and testing a prototype 7th and 8th grade model program that was organized and test-implemented in two distinct project phases: Phase I of the CMSP effort was conducted from 1991 to 1995 as a 7th to 8th grade extension of an existing K-6 elementary school, and Phase II was conducted from 1995 to 1998 as a 7th to 8th grade middle school program that became an integral part of a newly established 7-12th grade high school. In Phase I, the CMSP demonstrated that with a highly structured curriculum coupled with strong academic support and increased learning time, students participating in the CMSP were able to develop a strong foundation for rigorous high school coursework within the space of 2 years (at the 7th and 8th grades). Mathematics and Reading test score data during Phase I of the project, clearly indicated that significant academic gains were obtained by almost all students -- at both the high and low ends of the spectrum -- regardless of their previous academic performance in the K-6 elementary school experience. The CMSP effort expanded in Phase II to include a fully operating 7-12 high school model. Achievement gains at the 7th and 8th grade levels in Phase II were tempered by the fact that incoming 7th grade students' academic background at the CMSP High School was significantly lower than students participating in Phase 1. Student performance in Phase II was also affected by the broadening of the CMSP effort from a 7-8th grade program to a fully functioning 7-12 high school which as a consequence lessened the focus and structure available to the 7-8th grade students and teachers -- as compared to Phase I. Nevertheless, the CMSP does represent a unique curriculum model for 7th and 8th grade students in urban middle schools. Experience in both Phase I and Phase II of the project allowed the CMSP to be developed and tested along the broad range of parameters and characteristics that embody an operating public school in an urban environment.

Trusted Truck(R) II (phase A).

DOT National Transportation Integrated Search

2009-01-01

The Trusted Truck Program was initiated in 2003 as a joint effort by NTRCI, Volvo and UT. The vision of the Trusted Truck program is to develop a secure and "trusted" transport solution from pickup to delivery. The program's objective is to incre...

COAL CONVERSION CONTROL TECHNOLOGY. VOLUME II. GASEOUS EMISSIONS; SOLID WASTES

EPA Science Inventory

This volume is the product of an information-gathering effort relating to coal conversion process streams. Available and developing control technology has been evaluated in view of the requirements of present and proposed federal, state, regional, and international environmental ...

How Effective Have Thirty Years of Internationally Driven Conservation and Development Efforts Been in Madagascar?

PubMed

Waeber, Patrick O; Wilmé, Lucienne; Mercier, Jean-Roger; Camara, Christian; Lowry, Porter P

2016-01-01

Conservation and development are intricately linked. The international donor community has long provided aid to tropical countries in an effort to alleviate poverty and conserve biodiversity. While hundreds of millions of $ have been invested in over 500 environmental-based projects in Madagascar during the period covered by a series of National Environmental Action Plans (1993-2008) and the protected areas network has expanded threefold, deforestation remains unchecked and none of the eight Millennium Development Goals (MDGs) established for 2000-2015 were likely be met. Efforts to achieve sustainable development had failed to reduce poverty or deliver progress toward any of the MDGs. Cross-sectorial policy adjustments are needed that (i) enable and catalyze Madagascar's capacities rather than deepening dependency on external actors such as the World Bank, the International Monetary Fund and donor countries, and that (ii) deliver improvements to the livelihoods and wellbeing of the country's rural poor.

MANUAL: BIOVENTING PRINCIPLES AND PRACTICE VOLUME II. BIOVENTING DESIGN

EPA Science Inventory

The results from bioventing research and development efforts and from the pilot-scale bioventing systems have been used to produce this two-volume manual. Although this design manual has been written based on extensive experience with petroleum hydrocarbons (and thus, many exampl...

Defence Science Research, Higher Education and the Australian Quest for the Atomic Bomb, 1945-60.

ERIC Educational Resources Information Center

Reynolds, Wayne

1997-01-01

Recounts the efforts of the Australian government to create an atomic research and development program after World War II. Describes initial cooperation with Britain and the push for the transformation of Australian higher and secondary education in service of national scientific development. Discusses effects of the end of Commonwealth…

The rideability of a deflected bridge approach slab (LTRC project 02-2GT continuation : phase II).

DOT National Transportation Integrated Search

2014-10-01

This report presents the findings associated with an effort to develop a complementary pavement : roughness indexing system that utilizes the 25 ft. Moving Baselength Roughness Index (IRI25-ft) : alongside the posted speed localized roughness index (...

National ITS Program Plan, Intelligent Transportation Systems Volume II

DOT National Transportation Integrated Search

1995-03-01

THE PURPOSE OF THE NATIONAL ITS PROGRAM PLAN IS TO GUIDE THE DEVELOPMENT AND DEPLOYMENT OF INTELLIGENT TRANSPORTATION SYSTEMS (ITS) IN THE UNITED STATES. THIS, THE FIRST EDITION OF THE PLAN WAS A JOINT EFFORT OF ITS AMERICA AND THE UNITED STATES DEPA...

USEPA RESEARCH ON INFILTRATION/INFLOW CONTROL

EPA Science Inventory

From the late 60's to early 80's, the USEPA conducted a series of research, development, and demonstration projects on the characterization, cause and consequence, and control of infiltation/inflow (I/I) in both sanitary and combined sewers. The research effort was driven by the ...

USEPA RESEARCH ON INFILTRATION/INFLOW CONTROL

EPA Science Inventory

From the late 60's to early 80's, the USEPA conducted a series of research, development, and demonsration projects on the characterization, cause and consequence, and control of infiltation/inflow (I/I) in both sanitary and combined sewers. The research effort was driven by the n...

Dynamic FLIR Target Acquisition. Phase I.

DTIC Science & Technology

1978-08-02

The execution of the experimental plan developed and outlined in this report will make up the bulk of our second year effort. The third year will be...outlined in this report will make up the bulk of our second year effort. The third year will be devoted to further experimentation and analysis of...established. 2.1 TARGET SELECTION In an analysis of the success or failure of past air strike campaigns from WW II through the Six Day War (see Figure 2

AWIPS II in the University Community: Unidata's efforts and capabilities of the software

NASA Astrophysics Data System (ADS)

Ramamurthy, Mohan; James, Michael

2015-04-01

The Advanced Weather Interactive Processing System, version II (AWIPS II) is a weather forecasting, display and analysis tool that is used by the National Oceanic and Atmospheric Administration/National Weather Service (NOAA/NWS) and the National Centers for Environmental Prediction (NCEP) to ingest analyze and disseminate operational weather data. The AWIPS II software is built on a Service Oriented Architecture, takes advantage of open source software, and its design affords expandability, flexibility, and portability. Since many university meteorology programs are eager to use the same tools used by NWS forecasters, Unidata community interest in AWIPS II is high. The Unidata Program Center (UPC) has worked closely with NCEP staff during AWIPS II development in order to devise a way to make it available to the university. The Unidata AWIPS II software was released in beta form in 2014, and it incorporates a number of key changes to the baseline U. S. National Weather Service release to process and display additional data formats and run all components in a single-server standalone configuration. In addition to making available open-source instances of the software libraries that can be downloaded and run at any university, Unidata has also deployed the data-server side of AWIPS II, known as EDEX, in the Amazon Web Service and Microsoft Azure cloud environments. In this set up, universities receive all of the data from remote cloud instances, while they only have to run the AWIPS II client, known as CAVE, to analyze and visualize the data. In this presentation, we will describe Unidata's AWIPS II efforts, including the capabilities of the software in visualizing many different types of real-time meteorological data and its myriad uses in university and other settings.

Research safety vehicle program (Phase II) specification review. Volume II. Final technical report, Jul 1975--Nov 1976

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pugliese, S.M.

1977-02-01

In Phase I of the Research Safety Vehicle Program (RSV), preliminary design and performance specifications were developed for a mid-1980's vehicle that integrates crashworthiness and occupant safety features with material resource conservation, economy, and producibility. Phase II of the program focused on development of the total vehicle design via systems engineering and integration analyses. As part of this effort, it was necessary to continuously review the Phase I recommended performance specification in relation to ongoing design/test activities. This document contains the results of analyses of the Phase I specifications. The RSV is expected to satisfy all of the producibility andmore » safety related specifications, i.e., handling and stability systems, crashworthiness, occupant protection, pedestrian/cyclist protection, etc.« less

Development of an intelligent hypertext system for wind tunnel testing

NASA Technical Reports Server (NTRS)

Lo, Ching F.; Shi, George Z.; Steinle, Frank W.; Wu, Y. C. L. Susan; Hoyt, W. Andes

1991-01-01

This paper summarizes the results of a system utilizing artificial intelligence technology to improve the productivity of project engineers who conduct wind tunnel tests. The objective was to create an intelligent hypertext system which integrates a hypertext manual and expert system that stores experts' knowledge and experience. The preliminary (Phase I) effort implemented a prototype IHS module encompassing a portion of the manuals and knowledge used for wind tunnel testing. The effort successfully demonstrated the feasibility of the intelligent hypertext system concept. A module for the internal strain gage balance, implemented on both IBM-PC and Macintosh computers, is presented. A description of the Phase II effort is included.

The impact of modifying antenna size of photosystem II on canopy photosynthetic efficiency – development of a new canopy photosynthesis model scaling from metabolism to canopy level processes

USDA-ARS?s Scientific Manuscript database

Canopy photosynthesis describes photosynthesis of an entire crop field and positively correlates with biomass production. Much effort in crop breeding has focused on improving canopy architecture and hence light distribution inside the canopy. Here, we develop a new integrated canopy photosynthesis ...

Computerized Adaptive Screening Test (CAST): Development for Use in Military Recruiting Stations

DTIC Science & Technology

1984-01-01

testing ( CAT ) 20. ABSTRACT (Continuo on rover .. efdo II neco .. ., ond Identity bJ’ 11/oclr -llor) The Computerized Adaptive Screening Test (CAST...effort is in progress to develop a computerized adaptive testing ( CAT ) system and to evaluate its potential for use in the military entrance...U.S. Marine Corps) has been designated as lead service for CAT system development; and the Navy Personnel Research and Development Center, as lead

Environmental Assessment of the Hawaii Geothermal Project Well Flow Test Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1976-11-01

The Hawaii Geothermal Project, a coordinated research effort of the University of Hawaii, funded by the County and State of Hawaii, and ERDA, was initiated in 1973 in an effort to identify, generate, and use geothermal energy on the Big Island of Hawaii. A number of stages are involved in developing geothermal power resources: exploration, test drilling, production testing, field development, power plant and powerline construction, and full-scale production. Phase I of the Project, which began in the summer of 1973, involved conducting exploratory surveys, developing analytical models for interpretation of geophysical results, conducting studies on energy recovery from hotmore » brine, and examining the legal and economic implications of developing geothermal resources in the state. Phase II of the Project, initiated in the summer of 1975, centers on drilling an exploratory research well on the Island of Hawaii, but also continues operational support for the geophysical, engineering, and socioeconomic activities delineated above. The project to date is between the test drilling and production testing phase. The purpose of this assessment is to describe the activities and potential impacts associated with extensive well flow testing to be completed during Phase II.« less

Trying to remember: Effort mediates the relationship between frequency of cannabis use and memory performance.

PubMed

Hirst, Rayna B; Young, Kaitlyn R; Sodos, Louise M; Wickham, Robert E; Earleywine, Mitch

2017-06-01

While many studies suggest that regular cannabis use leads to deficits in cognitive functioning, particularly in memory, few have measured effort put forth during testing, and none have examined this as a potential mediator. Both age of onset of regular cannabis use and frequency of use have been linked to increased risk of memory deficits. The present study sought to determine whether effort mediated the relationship between frequency or age of onset of cannabis use and learning and memory performance. Sixty-two participants (74% male, mean age = 19.25 years) who met criteria for chronic cannabis use (four or more days per week for at least 12 months) completed a neuropsychological battery including the California Verbal Learning Test-II (CVLT-II) and the Rey Complex Figure (RCF) as measures of learning and memory, and the Word Memory Test (WMT) as a measure of effort put forth during neuropsychological assessment. Participants who more frequently used cannabis exhibited poorer effort (as measured by WMT performance; p < .01). Bootstrapping yielded 95% confidence intervals for indirect effects and revealed that effort significantly mediated the relationship between frequency of cannabis use and CVLT-II Learning (Sum of Trials 1-5), CVLT-II Delayed Recall, and RCF Delayed Recall, but not RCF Immediate Recall. Age of onset of cannabis use was not significantly related to effort. Findings indicate that effort mediates the relationship between frequency of cannabis use and performance on learning and memory measures, suggesting that effort performance should be measured and controlled for in future studies assessing cognition in frequent cannabis users.

EVALUATING TREATMENT TECHNOLOGIES - QA APPROACHES IN THE USA AND GERMANY

EPA Science Inventory

The US EPA and the German Federal Ministry of Education and Research entered into a Bilateral Agreement in 1990 to gain a better understanding of each country's efforts in developing and demonstrating remedial technologies. Under Phase II of the Agreement, SITe Program quality ma...

REDUCED COST SEWER PIPE RELINING USING ULTRASONIC TAPE LAMINATION - PHASE II

EPA Science Inventory

During the Phase I program, Foster-Miller developed techniques based on Ultrasonic Tape Lamination (UTL) for joining of plasticized PVC sewer pipe liner. This effort was undertaken in response to a need for environmentally sound and cost-effective methods for rehabilitation of...

Innovative grinding wheel design for cost-effective machining of advanced ceramics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Licht, R.H.; Kuo, P.; Liu, S.

2000-05-01

This Final Report covers the Phase II Innovative Grinding Wheel (IGW) program in which Norton Company successfully developed a novel grinding wheel for cost-effective cylindrical grinding of advanced ceramics. In 1995, Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics using small prototype wheels. The Phase II program was initiated to scale-up the new superabrasive wheel specification to larger diameters, 305-mm to 406-mm, required for most production grinding of cylindrical ceramic parts, and to perform in-house and independent validation grinding tests.

How Effective Have Thirty Years of Internationally Driven Conservation and Development Efforts Been in Madagascar?

PubMed Central

Wilmé, Lucienne; Mercier, Jean-Roger; Camara, Christian; Lowry, Porter P.

2016-01-01

Conservation and development are intricately linked. The international donor community has long provided aid to tropical countries in an effort to alleviate poverty and conserve biodiversity. While hundreds of millions of $ have been invested in over 500 environmental-based projects in Madagascar during the period covered by a series of National Environmental Action Plans (1993–2008) and the protected areas network has expanded threefold, deforestation remains unchecked and none of the eight Millennium Development Goals (MDGs) established for 2000–2015 were likely be met. Efforts to achieve sustainable development had failed to reduce poverty or deliver progress toward any of the MDGs. Cross-sectorial policy adjustments are needed that (i) enable and catalyze Madagascar’s capacities rather than deepening dependency on external actors such as the World Bank, the International Monetary Fund and donor countries, and that (ii) deliver improvements to the livelihoods and wellbeing of the country’s rural poor. PMID:27532499

Sustainable design guidelines to support the Washington State ferries terminal design manual : design guideline application and refinement.

DOT National Transportation Integrated Search

2013-08-01

The Sustainable Design Guidelines were developed in Phase I of this research program (WA-RD : 816.1). Here we are reporting on the Phase II effort that beta-tested the Phase I Guidelines on : example ferry terminal designs and refinements made ...

The AIBS In Yugoslavia: Programs in Biomedical Engineering

ERIC Educational Resources Information Center

Thompson, Mary-Frances

1978-01-01

Programs in biomedical engineering have been developing worldwide since World War II. This article describes a multidisciplinary program which operates in Yugoslavia through a cooperative effort between that county and the AIBS. A major problem has been the slowness with which hospitals accept the concept of biomedical engineering. (MA)

Compensation in a restructured environment. Part II: The past, present, and future of reward systems.

PubMed

Gerard, R; Speer, M

1995-01-01

The participants in the HR Consortium walked away satisfied that they had left "no stones unturned" in their efforts to create new compensation approaches. The major takeaway was that there is no ready panacea. The creation of an effective compensation system will be the development of an approach that does not serve as an obstacle to staff and managers in their efforts to build a hospital system that services customers in a restructured setting; rather it shadows and supports these operational changes.

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

PubMed Central

Johnstone, Timothy C.; Suntharalingam, Kogularamanan; Lippard, Stephen J.

2016-01-01

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing non-classical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore non-classical platinum(II) complexes with trans geometry and with a monofunctional coordination mode, polynuclear platinum(II) compounds, platinum(IV) prodrugs, dual-treat agents, and photoactivatable platinum(IV) complexes. Nanodelivery particles designed to deliver platinum(IV) complexes will also be discussed, including carbon nanotubes, carbon nanoparticles, gold nanoparticles, quantum dots, upconversion nanoparticles, and polymeric micelles. Additional nanoformulations including supramolecular self-assembled structures, proteins, peptides, metal-organic frameworks, and coordination polymers will then be described. Finally, the significant clinical progress made by nanoparticle formulations of platinum(II) agents will be reviewed. We anticipate that such a synthesis of disparate research efforts will not only help to generate new drug development ideas and strategies, but also reflect our optimism that the next generation of platinum cancer drugs is about to arrive. PMID:26865551

Teaching the Manhattan Project

ERIC Educational Resources Information Center

Schibuk, Elizabeth

2015-01-01

This article describes a nuclear chemistry unit on the Manhattan Project, a research effort that led to the development of the world's first nuclear weapons during World War II. The unit is appropriate for an introductory high school chemistry or physics course and takes from four to six weeks. The unit poses this essential question: "Over…

Forestry cooperatives: past and present

Treesearch

Mark G. Rickenbach

2006-01-01

Forest landowner cooperatives are not a new phenomenon, but past efforts to create and sustain these businesses have been largely unsuccessful in the U.S. Before and just after World War II saw significant investment in cooperative development that failed to create durable business. The purpose of this chapter is to briefly describe the history of forestry cooperatives...

Detector Developments for the High Luminosity LHC Era (4/4)

ScienceCinema

Bortoletto, Daniela

2018-02-09

Tracking Detectors - Part II. Calorimetry, muon detection, vertexing, and tracking will play a central role in determining the physics reach for the High Luminosity LHC Era. In these lectures we will cover the requirements, options, and the R&D; efforts necessary to upgrade the current LHC detectors and enabling discoveries.

HEAVY-DUTY DIESEL VEHICLE MODAL EMISSION MODEL (HDDV-MEM): VOLUME I: MODAL EMISSION MODELING FRAMEWORK; VOLUME II: MODAL COMPONENTS AND OUTPUTS

EPA Science Inventory

This research outlines a proposed Heavy-Duty Diesel Vehicle Modal Emission Modeling Framework (HDDV-MEMF) for heavy-duty diesel-powered trucks and buses. The heavy-duty vehicle modal modules being developed under this research effort, although different, should be compatible wi...

A strategy to improve priority setting in developing countries.

PubMed

Kapiriri, Lydia; Martin, Douglas K

2007-09-01

Because the demand for health services outstrips the available resources, priority setting is one of the most difficult issues faced by health policy makers, particularly those in developing countries. Priority setting in developing countries is fraught with uncertainty due to lack of credible information, weak priority setting institutions, and unclear priority setting processes. Efforts to improve priority setting in these contexts have focused on providing information and tools. In this paper we argue that priority setting is a value laden and political process, and although important, the available information and tools are not sufficient to address the priority setting challenges in developing countries. Additional complementary efforts are required. Hence, a strategy to improve priority setting in developing countries should also include: (i) capturing current priority setting practices, (ii) improving the legitimacy and capacity of institutions that set priorities, and (iii) developing fair priority setting processes.

Clinical utility of the Conners' Continuous Performance Test-II to detect poor effort in U.S. military personnel following traumatic brain injury.

PubMed

Lange, Rael T; Iverson, Grant L; Brickell, Tracey A; Staver, Tara; Pancholi, Sonal; Bhagwat, Aditya; French, Louis M

2013-06-01

The purpose of this study is to examine the clinical utility of the Conners' Continuous Performance Test (CPT-II) as an embedded marker of poor effort in military personnel undergoing neuropsychological evaluations following traumatic brain injury. Participants were 158 U.S. military service members divided into 3 groups on the basis of brain injury severity and performance (pass/fail) on 2 symptom validity tests: Mild Traumatic Brain Injury (MTBI)-Pass (n = 87), MTBI-Fail (n = 42), and severe traumatic brain injury (STBI)-Pass (n = 29). The MTBI-Fail group performed worse on the majority of CPT-II measures compared with both the MTBI-Pass and STBI-Pass groups. When comparing the MTBI-Fail group and MTBI-Pass groups, the most accurate measure for identifying poor effort was the Commission T score. When selected measures were combined (i.e., Omissions, Commissions, and Perseverations), there was a very small increase in sensitivity (from .26 to .29). When comparing the MTBI-Fail group and STBI-Pass groups, the most accurate measure for identifying poor effort was the Omission and Commissions T score. When selected measures were combined, sensitivity again increased (from .24 to .45). Overall, these results suggest that individual CPT-II measures can be useful for identifying people who are suspected of providing poor effort from those who have provided adequate effort. However, due to low sensitivity and modest negative predictive power values, this measure cannot be used in isolation to detect poor effort, and is largely useful as a test to "rule in," not "rule out" poor effort. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Descriptive Summaries of the Research Development Test & Evaluation Army Appropriation FY 1983. Supporting Data FY 1983, Budget Estimate Submitted to Congress February 1982. Volume II.

DTIC Science & Technology

1982-02-01

Defense (BHD) Advanced Technology Program is a broadly based rsearch and development effort designed to exploit new and emerging technologies...11-363 DK13 NON -COMMUNICATIONS ELECTRONIC COUNTERMEASURES SYSTEMS .............................. .11-368 DK14 EXPENDABLE JAMMERS...NAVSTAR GLOBAL POSITIONING SYSTEMS (GPS) USER EQUIPMENT .................................. 111-366 DEFENSEWIDE MISSION SUPPORT 6.37.38.A NON -SYSTEMS

Advanced Boost System Developing for High EGR Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Harold

2012-09-30

To support industry efforts of clean and efficient internal combustion engine development for passenger and commercial applications • This program focuses on turbocharger improvement for medium and light duty diesel applications, from complete system optimization percepective to enable commercialization of advanced diesel combustion technologies, such as HCCI/LTC. • Improve combined turbocharger efficiency up to 10% or fuel economy by 3% on FTP cycle at Tier II Bin 5 emission level.

Antimalarial compounds in Phase II clinical development.

PubMed

Held, Jana; Jeyaraj, Sankarganesh; Kreidenweiss, Andrea

2015-03-01

Malaria is a major health problem in endemic countries and chemotherapy remains the most important tool in combating it. Treatment options are limited and essentially rely on a single drug class - the artemisinins. Efforts are ongoing to restrict the evolving threat of artemisinin resistance but declining sensitivity has been reported. Fueled by the ambitious aim of malaria eradication, novel antimalarial compounds, with improved properties, are now in the progressive phase of drug development. Herein, the authors describe antimalarial compounds currently in Phase II clinical development and present the results of these investigations. Thanks to recent efforts, a number of promising antimalarial compounds are now in the pipeline. First safety data have been generated for all of these candidates, although their efficacy as antimalarials is still unclear for most of them. Of particular note are KAE609, KAF156 and DSM265, which are of chemical scaffolds new to malaria chemotherapy and would truly diversify antimalarial options. Apart from SAR97276, which also has a novel chemical scaffold that has had its development stopped, all other compounds in the pipeline belong to already known substance classes, which have been chemically modified. At this moment in time, there is not one standout compound that will revolutionize malaria treatment but several compounds that will add to its control in the future.

Viability of thin wall tube forming of ATF FeCrAl

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maloy, Stuart Andrew; Aydogan, Eda; Anderoglu, Osman

Fabrication of thin walled tubing of FeCrAl alloys is critical to its success as a candidate enhanced accident-tolerant fuel cladding material. Alloys that are being investigated are Generation I and Generation II FeCrAl alloys produced at ORNL and an ODS FeCrAl alloy, MA-956 produced by Special Metals. Gen I and Gen II FeCrAl alloys were provided by ORNL and MA-956 was provided by LANL (initially produced by Special Metals). Three tube development efforts were undertaken. ORNL led the FeCrAl Gen I and Gen II alloy development and tube processing studies through drawing tubes at Rhenium Corporation. LANL received alloys frommore » ORNL and led tube processing studies through drawing tubes at Century Tubing. PNNL led the development of tube processing studies on MA-956 through pilger processing working with Sandvik Corporation. A summary of the recent progress on tube development is provided in the following report and a separate ORNL report: ORNL/TM-2015/478, “Development and Quality Assessments of Commercial Heat Production of ATF FeCrAl Tubes”.« less

ATLAS Beam Steering Mechanism (BSM) Lessons Learned

NASA Technical Reports Server (NTRS)

Blumenstock, Kenneth A.; Cramer, Alexander K.; Gosten, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morell, Armando;

ATLAS Beam Steering Mechanism Lessons Learned

NASA Technical Reports Server (NTRS)

Blumenstock, Kenneth A.; Cramer, Alexander K.; Gostin, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morrell, Armando;

Geothermal energy: opportunities for California commerce. Phase I report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Longyear, A.B.

1981-12-01

The potential geothermal direct-use energy market and its application to projects in California are assessed. Project identification effort is to be focused on those that have the highest probability for near-term successful commercial operations. Near-term herein means 2 to 5 years for project implementation. Phase I has been focused on defining and assessing: (1) the geothermal direct-use resources that are suitable for near-term utilization; and (2) the generic applications (municipal heating districts, horticultural greenhouse firms, laundries, etc.) that are suitable for near-term projects. Five economic development regions in the state, containing recognized geothermal direct-use resources, have been defined. Thirty-eight directmore » use resources have been evaluated in these regions. After assessment against pre-selected criteria, twenty-seven have been rated with a priority of I, II or III, thereby qualifying them for further marketing effort. The five areas with a priority of I are summarized. These areas have no perceived impediments to near-term development. Twenty-nine generic categories of applications were assessed against previously selected criteria to determine their near term potential for direct use of geothermal fluids. Some twenty industry, commercial and institutional application categories were rated with a priority of I, II or III and warrant further marketing efforts. The seven categories with a priority of I are listed. These categories were found to have the least impediments to near-term application projects.« less

Mexican Americans on the Home Front: Community Organizations in Arizona during World War II.

ERIC Educational Resources Information Center

Marin, Christine

During World War II Arizona's Mexican-American communities organized their own patriotic activities and worked, in spite of racism, to support the war effort. In Phoenix the Lenadores del Mundo, an active fraternal society, began this effort by sponsoring a festival in January 1942. Such "mutualistas" provided an essential support system…

Development of mercury (II) ion biosensors based on mercury-specific oligonucleotide probes.

PubMed

Li, Lanying; Wen, Yanli; Xu, Li; Xu, Qin; Song, Shiping; Zuo, Xiaolei; Yan, Juan; Zhang, Weijia; Liu, Gang

2016-01-15

Mercury (II) ion (Hg(2+)) contamination can be accumulated along the food chain and cause serious threat to the public health. Plenty of research effort thus has been devoted to the development of fast, sensitive and selective biosensors for monitoring Hg(2+). Thymine was demonstrated to specifically combine with Hg(2+) and form a thymine-Hg(2+)-thymine (T-Hg(2+)-T) structure, with binding constant even higher than T-A Watson-Crick pair in DNA duplex. Recently, various novel Hg(2+) biosensors have been developed based on T-rich Mercury-Specific Oligonucleotide (MSO) probes, and exhibited advanced selectivity and excellent sensitivity for Hg(2+) detection. In this review, we explained recent development of MSO-based Hg(2+) biosensors mainly in 3 groups: fluorescent biosensors, colorimetric biosensors and electrochemical biosensors. Copyright © 2015 Elsevier B.V. All rights reserved.

International perspectives on the physical inactivity crisis--structural solutions over evidence generation?

PubMed

Bauman, Adrian; Finegood, Diane T; Matsudo, Victor

2009-10-01

Many programs to increase physical activity have been evaluated in developed countries, where 'leisure time physical activity' is the most frequent domain for interventions. In developing countries, and also with reference to global obesity prevention, different kinds of interventions targeting 'total physical activity' are needed. This requires efforts across agencies and sectors, and in the domains of work, active transport, reduced sitting time, as well as leisure time physical activity promotion. In considering possible solutions, this commentary examined the use of complex systems, where integrated efforts across sectors and agencies might, in combination, contribute to increasing total physical activity. The key sets of actions required globally to increase physical activity were, in our opinion, [i] efforts to disseminate individual-level behavior change programs to reach much larger populations rather than volunteers, [ii] social marketing and mass communication campaigns to change social norms in the community and among professionals and policymakers, [iii] efforts to influence the social and physical environment to make them more conducive to physical activity, and [iv] the development and implementation of national physical activity plans and strategies, with sufficient timelines and resources to achieve measurable change.

Project SUN (Students Understanding Nature)

NASA Technical Reports Server (NTRS)

Curley, T.; Yanow, G.

1995-01-01

Project SUN is part of NASA's 'Mission to Planet Earth' education outreach effort. It is based on development of low cost, scientifi- cally accurate instrumentation and computer interfacing, coupled with Apple II computers as dedicated data loggers. The project is com- prised of: instruments, interfacing, software, curriculum, a detailed operating manual, and a system of training at the school sites.

National Program for Solar Heating and Cooling of Buildings. Project Data Summaries. Vol. II: Demonstration Support.

ERIC Educational Resources Information Center

Energy Research and Development Administration, Washington, DC. Div. of Solar Energy.

Brief abstracts of projects funded by the Energy Research and Development Administration (ERDA) and conducted under the National Program for Solar Heating and Cooling of Buildings are presented in three volumes. This, the second volume, identifies the major efforts currently underway in support of the national program. The National Aeronautics and…

What Is Next after 40 Years? Part 1: Prior Learning Assessment--1970-2011

ERIC Educational Resources Information Center

Travers, Nan L.

2012-01-01

Education practices focused on adult learners, such as prior learning assessment (PLA), are becoming more established in the United States. Initially, PLA was developed to provide greater access to higher education for World War II veterans and later for adult learners more generally as a way to balance the concentrated efforts most colleges and…

MnDOT 2014 peer exchange : quantifying & communicating the value of research implementation for MnROAD phase-II research projects and development of MnROAD's future research.

DOT National Transportation Integrated Search

2014-06-01

MnDOT Research Services hosted a national peer exchange in Minneapolis, Minnesota from June 10-12, : 2014, that focused on the research and implementation efforts of the MnROAD cold region pavement : testing facility and laboratory. The goal of the p...

Determination of Trace Elements in Uranium by HPLC-ID-ICP-MS: NTNFC Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manard, Benjamin Thomas; Wylie, Ernest Miller II; Xu, Ning

This report covers the FY 16 effort for the HPLC-ID-ICP-MS methodology 1) sub-method validation for the group I&II elements, 2) sub-method stood-up and validation for REE, 3) sub-method development for the transition element, and 4) completion of a comprehensive SOP for three families of elements.

Development of an Integrated, Computer-Based Bibliographical Data System for a Large University Library. Annual Report to the National Science Foundation from the University of Chicago Library, 1966/67.

ERIC Educational Resources Information Center

Fussler, Herman; Payne, Charles T.

Part I is a discussion of the following project tasks: A) development of an on-line, real-time bibliographic data processing system; B) implementation in library operations; C) character sets; D) Project MARC; E) circulation; and F) processing operation studies. Part II is a brief discussion of efforts to work out cooperative library systems…

Development of an Autonomous, Compact, Broadband Acoustic Backscattering System for Remote Characterization of Zooplankton Variability (PART II)

DTIC Science & Technology

2010-09-30

proposal include: 1) complete the development of second-generation sonar boards, 2) complete the integration of new transducers with the second... sonar board and transducer. APPROACH Over the last 40 years, there has been significant research effort directed towards the use of high...narrowband frequency, and some AUVs carry single-frequency sidescan sonars (and this technology has been adapted for gliders), the lack of suitable

Integration of Rotor Aerodynamic Optimization with the Conceptual Design of a Large Civil Tiltrotor

NASA Technical Reports Server (NTRS)

Acree, C. W., Jr.

2010-01-01

Coupling of aeromechanics analysis with vehicle sizing is demonstrated with the CAMRAD II aeromechanics code and NDARC sizing code. The example is optimization of cruise tip speed with rotor/wing interference for the Large Civil Tiltrotor (LCTR2) concept design. Free-wake models were used for both rotors and the wing. This report is part of a NASA effort to develop an integrated analytical capability combining rotorcraft aeromechanics, structures, propulsion, mission analysis, and vehicle sizing. The present paper extends previous efforts by including rotor/wing interference explicitly in the rotor performance optimization and implicitly in the sizing.

Institutional Self-Analysis and Long-Range Planning in a Small Liberal Arts College. Part II-- Study Procedure.

ERIC Educational Resources Information Center

Frame, Stanley M.

In the Spring of 1969, Bethany Nazarene College started an intensive self evaluation effort, called the Ten-Year Advance Study. Part I of the report, the Study Design, was published in October 1969. This study, Part II, relates the study activities, the methodology, and sources consulted. The effort involved over 120 administrators, faculty,…

First principles materials design of novel functional oxides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, Valentino R.; Voas, Brian K.; Bridges, Craig A.

2016-05-31

We review our efforts to develop and implement robust computational approaches for exploring phase stability to facilitate the prediction-to-synthesis process of novel functional oxides. These efforts focus on a synergy between (i) electronic structure calculations for properties predictions, (ii) phenomenological/empirical methods for examining phase stability as related to both phase segregation and temperature-dependent transitions and (iii) experimental validation through synthesis and characterization. We illustrate this philosophy by examining an inaugural study that seeks to discover novel functional oxides with high piezoelectric responses. Lastly, our results show progress towards developing a framework through which solid solutions can be studied to predictmore » materials with enhanced properties that can be synthesized and remain active under device relevant conditions.« less

On Logic and Standards for Structuring Documents

NASA Astrophysics Data System (ADS)

Eyers, David M.; Jones, Andrew J. I.; Kimbrough, Steven O.

The advent of XML has been widely seized upon as an opportunity to develop document representation standards that lend themselves to automated processing. This is a welcome development and much good has come of it. That said, present standardization efforts may be criticized on a number of counts. We explore two issues associated with document XML standardization efforts. We label them (i) the dynamic point and (ii) the logical point. Our dynamic point is that in many cases experience has shown that the search for a final, or even reasonably permanent, document representation standard is futile. The case is especially strong for electronic data interchange (EDI). Our logical point is that formalization into symbolic logic is materially helpful for understanding and designing dynamic document standards.

Continuation of support for the Intercampus Institute for Research at Particle Accelerators. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caldwell, D.; Eisner, A.

1997-10-01

During the budget period beginning May 16, 1995, the UCSD group of the U.C. Intercampus Institute for Research at Particle Accelerators devoted approximately 75% of its effort to the PEP-II B Factory and the associated BABAR detector at SLAC, and 25% of its effort to the LSND collaboration at LAMPF. Michael Sullivan spent all of his time on PEP-II, while Alan Eisner split his time between BABAR and LSND. Sullivan remained a critical member of the group designing the PEP-II interaction region and the machine-detector interface; and, in fact, toward the end of the period he left IIRPA to becomemore » a SLAC employee, in order to ensure his continued participation in those efforts. That work has focused on developing an interaction region in which the accelerator can achieve the required high specific luminosity while, at the same time, maintaining low enough beam background to allow a detector to operate. Both requirements are essential to achieving the primary physics goal of not only detecting but doing detailed measurements of CP violation. Eisner`s work on the BABAR detector concentrated on the electromagnetic (CsI crystal) calorimeter. With the calorimeter geometry largely established, he turned his attention more fully to the areas of calorimeter data acquisition and calibration. The data acquisition focus, was on understaning the performance of the proposed system via calculations and simulations, a joint project with Yao-xin Wang of the UCSB IIRPA group.« less

A case history of technology transfer

NASA Technical Reports Server (NTRS)

1981-01-01

A sequence of events, occurring over the last 25 years, are described that chronicle the evolution of ion-bombardment electric propulsion technology. Emphasis is placed on the latter phases of this evolution, where special efforts were made to pave the way toward the use of this technology in operational space flight systems. These efforts consisted of a planned program to focus the technology toward its end applications and an organized process that was followed to transfer the technology from the research-technology NASA Center to the user-development NASA Center and its industry team. Major milestones in this evolution, which are described, include the development of thruster technology across a large size range, the successful completion of two space electric rocket tests, SERT I and SERT II, development of power-processing technology for electric propulsion, completion of a program to make the technology ready for flight system development, and finally the technology transfer events.

Centrifuge workers study. Phase II, completion report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wooten, H.D.

1994-09-01

Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey tomore » evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom.« less

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV

PubMed Central

Kim, Michelle B.; Giesler, Kyle E.; Tahirovic, Yesim A.; Truax, Valarie M.; Liotta, Dennis C.; Wilson, Lawrence J.

2018-01-01

Introduction The chemokine receptor CCR5 has garnered significant attention in recent years as a target to treat HIV infection largely due to the approval and success of the drug Maraviroc. The side effects and inefficiencies with other first generation agents led to failed clinical trials, prompting the development of newer CCR5 antagonists. Areas covered This review aims to survey the current status of ‘next generation’ CCR5 antagonists in the preclinical pipeline with an emphasis on emerging agents for the treatment of HIV infection. These efforts have culminated in the identification of advanced second-generation agents to reach the clinic and the dual CCR5/CCR2 antagonist Cenicriviroc as the most advanced currently in phase II clinical studies. Expert opinion The clinical success of CCR5 inhibitors for treatment of HIV infection has rested largely on studies of Maraviroc and a second-generation dual CCR5/CCR2 antagonist Cenicriviroc. Although research efforts identified several promising preclinical candidates, these were dropped during early clinical studies. Despite patient access to Maraviroc, there is insufficient enthusiasm surrounding its use as front-line therapy for treatment of HIV. The non-HIV infection related development activities for Maraviroc and Cenicriviroc may help drive future interests. PMID:27791451

21 CFR 898.13 - Compliance dates.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Frequency. 1 73 FLS 868.2375 II Monitor (Apnea Detector), Ventilatory Effort. 1 74 DPS 870.2340 II... Connector). 1 74 DSH 870.2800 II Recorder, Magnetic Tape, Medical. 1 74 DSI 870.1025 III Detector and Alarm...

21 CFR 898.13 - Compliance dates.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Frequency. 1 73 FLS 868.2375 II Monitor (Apnea Detector), Ventilatory Effort. 1 74 DPS 870.2340 II... Connector). 1 74 DSH 870.2800 II Recorder, Magnetic Tape, Medical. 1 74 DSI 870.1025 III Detector and Alarm...

21 CFR 898.13 - Compliance dates.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Frequency. 1 73 FLS 868.2375 II Monitor (Apnea Detector), Ventilatory Effort. 1 74 DPS 870.2340 II... Connector). 1 74 DSH 870.2800 II Recorder, Magnetic Tape, Medical. 1 74 DSI 870.1025 III Detector and Alarm...

21 CFR 898.13 - Compliance dates.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Frequency. 1 73 FLS 868.2375 II Monitor (Apnea Detector), Ventilatory Effort. 1 74 DPS 870.2340 II... Connector). 1 74 DSH 870.2800 II Recorder, Magnetic Tape, Medical. 1 74 DSI 870.1025 III Detector and Alarm...

21 CFR 898.13 - Compliance dates.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Frequency. 1 73 FLS 868.2375 II Monitor (Apnea Detector), Ventilatory Effort. 1 74 DPS 870.2340 II... Connector). 1 74 DSH 870.2800 II Recorder, Magnetic Tape, Medical. 1 74 DSI 870.1025 III Detector and Alarm...

NOAA Observing System Integrated Analysis (NOSIA): development and support to the NOAA Satellite Observing System Architecture

NASA Astrophysics Data System (ADS)

Reining, R. C.; Cantrell, L. E., Jr.; Helms, D.; LaJoie, M.; Pratt, A. S.; Ries, V.; Taylor, J.; Yuen-Murphy, M. A.

2016-12-01

There is a deep relationship between NOSIA-II and the Federal Earth Observation Assessment (EOA) efforts (EOA 2012 and 2016) chartered under the National Science and Technology Council, Committee on Environment, Natural Resources, and Sustainability, co-chaired by the White House Office of Science and Technology Policy, NASA, NOAA, and USGS. NOSIA-1, which was conducted with a limited scope internal to NOAA in 2010, developed the methodology and toolset that was adopted for EOA 2012, and NOAA staffed the team that conducted the data collection, modeling, and analysis effort for EOA 2012. EOA 2012 was the first-ever integrated analysis of the relative impact of 379 observing systems and data sources contributing to the key objectives identified for 13 Societal Benefit Areas (SBA) including Weather, Climate, Disasters, Oceans and Coastal Resources, and Water Resources. This effort culminated in the first National Plan for Civil Earth Observations. NOAA conducted NOSIA-II starting in 2012 to extend the NOSIA methodology across all of NOAA's Mission Service Areas, covering a representative sample (over 1000) of NOAA's products and services. The detailed information from NOSIA-II is being integrated into EOA 2016 to underpin a broad array of Key Products, Services, and (science) Objectives (KPSO) identified by the inter-agency SBA teams. EOA 2016 is expected to provide substantially greater insight into the cross-agency impacts of observing systems contributing to a wide array of KPSOs, and by extension, to societal benefits flowing from these public-facing products. NOSIA-II is being adopted by NOAA as a corporate decision-analysis and support capability to inform leadership decisions on its integrated observing systems portfolio. Application examples include assessing the agency-wide impacts of planned decommissioning of ships and aircraft in NOAA's fleet, and the relative cost-effectiveness of alternative space-based architectures in the post-GOES-R and JPSS era. Like EOA, NOSIA is not limited to NOAA observing systems, and takes the contribution of observing systems from other agencies, the public sector, and international partnerships into account.

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Jia; Harrison, Rane A.; Li, Lianbo

KRAS G12C, the most common RAS mutation found in non-small-cell lung cancer, has been the subject of multiple recent covalent small-molecule inhibitor campaigns including efforts directed at the guanine nucleotide pocket and separate work focused on an inducible pocket adjacent to the switch motifs. Multiple conformations of switch II have been observed, suggesting that switch II pocket (SIIP) binders may be capable of engaging a range of KRAS conformations. Here we report the use of hydrogen/deuterium-exchange mass spectrometry (HDX MS) to discriminate between conformations of switch II induced by two chemical classes of SIIP binders. We investigated the structural basismore » for differences in HDX MS using X-ray crystallography and discovered a new SIIP configuration in response to binding of a quinazoline chemotype. These results have implications for structure-guided drug design targeting the RAS SIIP.« less

Nonlinear Representation and Pulse Testing of Communication Subsystems.

DTIC Science & Technology

1982-05-01

The Post-Doctoral Program provides an opportunity for faculty at participating universities to spend up to one year full time on explora- tory...development and problem-solving efforts with the post-doctorals splitting their time between the customer location and their educational institutions. The...CHAPTER II z-DOMAIN CHARACTERIZATION OF THE QUJADRATIC VOLTERRA SYSTEM................3 2.1 Continuous- Time Analysis .................. 3 Rational

Sensitive Equipment Decontamination

DTIC Science & Technology

2017-10-01

tomorrow’s CBRN threats. The document was elaborated by a group of scientists and CBRN specialists, all being members of the Hazard Management ... Management Panel within NATO Joint CBRN Defence Capability Development Group ii STO-TR-HFM-233 The NATO Science and Technology...accordance with NATO policies. The total spectrum of this collaborative effort is addressed by six Technical Panels who manage a wide range of scientific

The Five-Year Strategic Plan for Pilots, Demonstration Research and Evaluations, July 2000-June 2005.

ERIC Educational Resources Information Center

Van Horn, Carl; Fichtner, Aaron; Altman, Jennifer; Whittaker, Julie

This report contains the strategic vision for the Department of Labor (DOL)/Employment and Training Administration's research efforts for the next five years. Section I discusses the scope of the research plan and the development process. Section II is a review of literature concerning functioning of the labor market and identification of areas…

A Strategic Plan for Promoting and Expanding Apprenticeship in the U.S. (Phase II). Recommendations of the Federal Committee on Apprenticeship.

ERIC Educational Resources Information Center

Employment and Training Administration (DOL), Washington, DC. Office of Work-Based Learning.

In preparing Phase I of the Strategic Plan, the Federal Committee on Apprenticeship noted that efforts beyond education and technical assistance may be needed to develop apprenticeship fully in the United States. Specifically, the committee would examine and make recommendations with respect to such issues as incentives for participation,…

Competency-based education and training in internal medicine.

PubMed

Weinberger, Steven E; Pereira, Anne G; Iobst, William F; Mechaber, Alex J; Bronze, Michael S

2010-12-07

Recent efforts to improve medical education include adopting a new framework based on 6 broad competencies defined by the Accreditation Council for Graduate Medical Education. In this article, the Alliance for Academic Internal Medicine Education Redesign Task Force II examines the advantages and challenges of a competency-based educational framework for medical residents. Efforts to refine specific competencies by developing detailed milestones are described, and examples of training program initiatives using a competency-based approach are presented. Meeting the challenges of a competency-based framework and supporting these educational innovations require a robust faculty development program. Challenges to competency-based education include teaching and evaluating the competencies related to practice-based learning and improvement and systems-based practice, as well as implementing a flexible time frame to achieve competencies. However, the Alliance for Academic Internal Medicine Education Redesign Task Force II does not favor reducing internal medicine training to less than 36 months as part of competency-based education. Rather, the 36-month time frame should allow for remediation to address deficiencies in achieving competencies and for diverse enrichment experiences in such areas as quality of care and practice improvement for residents who have demonstrated skills in all required competencies.

Report on Project to Characterize Multi-Junction Solar Cells in the Stratosphere using Low-Cost Balloon and Communication Technologies

NASA Technical Reports Server (NTRS)

Mirza, Ali; Sant, David; Woodyard, James R.; Johnston, Richard R.; Brown, William J.

2002-01-01

Balloon, control and communication technologies are under development in our laboratory for testing multi-junction solar cells in the stratosphere to achieve near AM0 conditions. One flight, Suntracker I, has been carried out reported earlier. We report on our efforts in preparation for a second flight, Suntracker II, that was aborted due to hardware problems. The package for Suntracker I system has been modified to include separate electronics and battery packs for the 70 centimeter and 2 meter systems. The collimator control system and motor gearboxes have been redesigned to address problems with the virtual stops and backlash. Surface mount technology on a printed circuit board was used in place of the through-hole prototype circuit in efforts to reduce weight and size, and improve reliability. A mobile base station has been constructed that includes a 35' tower with a two axis rotator and multi-element yagi antennas. Modifications in Suntracker I and the factors that lead to aborting Suntracker II are discussed.

On-Line Enrichment Monitor (OLEM) Phase II Final Report Techniques and Equipment for Safeguards at Gas Centrifuge Enrichment Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Younkin, James R.; Garner, James R.

2017-04-01

Over the last five years, OLEM has been a collaborative development effort involving the IAEA, LANL, ORNL, URENCO, and the NNSA. The collective team has completed the following: design and modelling, software development, hardware integration, testing with the ORNL UF6 Flow Loop, a field trial at the Urenco facility in Almelo, the Netherlands, and a Demonstration at the Urenco USA facility in Eunice, New Mexico. This combined effort culminated in the deployment of several OLEM collection nodes in Iran. These OLEM units are one unattended monitoring system component of the Joint Comprehensive Plan of Action allowing the International Atomic Energymore » Agency to verify Iran’s compliance with the enrichment production aspects of the agreement.« less

Advances in Electrically Driven Thermal Management

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2017-01-01

Electrically Driven Thermal Management is a vibrant technology development initiative incorporating ISS based technology demonstrations, development of innovative fluid management techniques and fundamental research efforts. The program emphasizes high temperature high heat flux thermal management required for future generations of RF electronics and power electronic devices. This presentation reviews i.) preliminary results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched on STP-H5 payload in February 2017 ii.) advances in liquid phase flow distribution control iii.) development of the Electrically Driven Liquid Film Boiling Experiment under the NASA Microgravity Fluid Physics Program.

Respiratory Infections in the U.S. Military: Recent Experience and Control

PubMed Central

Cooper, Michael J.; Myers, Christopher A.; Cummings, James F.; Vest, Kelly G.; Russell, Kevin L.; Sanchez, Joyce L.; Hiser, Michelle J.; Gaydos, Charlotte A.

2015-01-01

SUMMARY This comprehensive review outlines the impact of military-relevant respiratory infections, with special attention to recruit training environments, influenza pandemics in 1918 to 1919 and 2009 to 2010, and peacetime operations and conflicts in the past 25 years. Outbreaks and epidemiologic investigations of viral and bacterial infections among high-risk groups are presented, including (i) experience by recruits at training centers, (ii) impact on advanced trainees in special settings, (iii) morbidity sustained by shipboard personnel at sea, and (iv) experience of deployed personnel. Utilizing a pathogen-by-pathogen approach, we examine (i) epidemiology, (ii) impact in terms of morbidity and operational readiness, (iii) clinical presentation and outbreak potential, (iv) diagnostic modalities, (v) treatment approaches, and (vi) vaccine and other control measures. We also outline military-specific initiatives in (i) surveillance, (ii) vaccine development and policy, (iii) novel influenza and coronavirus diagnostic test development and surveillance methods, (iv) influenza virus transmission and severity prediction modeling efforts, and (v) evaluation and implementation of nonvaccine, nonpharmacologic interventions. PMID:26085551

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gharibyan, N.

In order to fully characterize the NIF neutron spectrum, SAND-II-SNL software was requested/received from the Radiation Safety Information Computational Center. The software is designed to determine the neutron energy spectrum through analysis of experimental activation data. However, given that the source code was developed in Sparcstation 10, it is not compatible with current version of FORTRAN. Accounts have been established through the Lawrence Livermore National Laboratory’s High Performance Computing in order to access different compiles for FORTRAN (e.g. pgf77, pgf90). Additionally, several of the subroutines included in the SAND-II-SNL package have required debugging efforts to allow for proper compiling ofmore » the code.« less

VIIRS validation and algorithm development efforts in coastal and inland Waters

NASA Astrophysics Data System (ADS)

Stengel, E.; Ondrusek, M.

2016-02-01

Accurate satellite ocean color measurements in coastal and inland waters are more challenging than open-ocean measurements. Complex water and atmospheric conditions can limit the utilization of remote sensing data in coastal waters where it is most needed. The Coastal Optical Characterization Experiment (COCE) is an ongoing project at NOAA/NESDIS/STAR Satellite Oceanography and Climatology Division. The primary goals of COCE are satellite ocean color validation and application development. Currently, this effort concentrates on the initialization and validation of the Joint Polar Satellite System (JPSS) VIIRS sensor using a Satlantic HyperPro II radiometer as a validation tool. A report on VIIRS performance in coastal waters will be given by presenting comparisons between in situ ground truth measurements and VIIRS retrievals made in the Chesapeake Bay, and inland waters of the Gulf of Mexico and Puerto Rico. The COCE application development effort focuses on developing new ocean color satellite remote sensing tools for monitoring relevant coastal ocean parameters. A new VIIRS total suspended matter algorithm will be presented for the Chesapeake Bay. These activities improve the utility of ocean color satellite data in monitoring and analyzing coastal and oceanic processes. Progress on these activities will be reported.

Advanced rotary engine components utilizing fiber reinforced Mg castings

NASA Technical Reports Server (NTRS)

Goddard, D.; Whitman, W.; Pumphrey, R.; Lee, C.-M.

1986-01-01

Under a two-phase program sponsored by NASA, the technology for producing advanced rotary engine components utilizing graphite fiber-reinforced magnesium alloy casting is being developed. In Phase I, the successful casting of a simulated intermediate housing was demonstrated. In Phase II, the goal is to produce an operating rotor housing. The effort involves generation of a material property data base, optimization of parameters, and development of wear- and corrosion-resistant cast surfaces and surface coatings. Results to date are described.

Development Roadmap of an Evolvable and Extensible Multi-Mission Telecom Planning and Analysis Framework

NASA Technical Reports Server (NTRS)

Cheung, Kar-Ming; Tung, Ramona H.; Lee, Charles H.

2003-01-01

In this paper, we describe the development roadmap and discuss the various challenges of an evolvable and extensible multi-mission telecom planning and analysis framework. Our long-term goal is to develop a set of powerful flexible telecommunications analysis tools that can be easily adapted to different missions while maintain the common Deep Space Communication requirements. The ability of re-using the DSN ground models and the common software utilities in our adaptations has contributed significantly to our development efforts measured in terms of consistency, accuracy, and minimal effort redundancy, which can translate into shorter development time and major cost savings for the individual missions. In our roadmap, we will address the design principles, technical achievements and the associated challenges for following telecom analysis tools (i) Telecom Forecaster Predictor - TFP (ii) Unified Telecom Predictor - UTP (iii) Generalized Telecom Predictor - GTP (iv) Generic TFP (v) Web-based TFP (vi) Application Program Interface - API (vii) Mars Relay Network Planning Tool - MRNPT.

Minority Recruiting in The New York City Police Department: Part I. The Attraction of Candidates, Part II. The Retention of Candidates.

ERIC Educational Resources Information Center

Hunt, Isaac C., Jr.; Cohen, Bernard

In an effort to increase the proportion of minority group members on the New York City police force, this study was commissioned: (1) to learn the reasons for present difficulties in minority recruitment, (2) to analyze the effectiveness of current recruiting strategies and programs, and (3) to develop new approaches aimed at improving minority…

Applications for Micrographics in Large Scale Information Systems of the Future. Volume II: Part III. A Review of Micrographics State-of-the-Art.

ERIC Educational Resources Information Center

Information Dynamics Corp., Reading, MA.

A five-year development program plan was drawn up for the Defense Documentation Center (DDC). This report presents in summary form the results of various surveys and reviews performed in selected areas of micrographics to support the efforts of the program's planners. Exhibits of supporting documentation are presented, together with a discussion…

An Assessment of the Nature and Extent of Community and Employee Fitness Programs and Levels of Participation. Final Report. Report No. 9.

ERIC Educational Resources Information Center

Bozzo, Robert; And Others

This report presents an assessment and comparison of the nature and extent of general population, employee, and school fitness programs. Chapter I provides an overview of the research effort and the research questions developed as a framework for delineating issues to be examined. Chapter II identifies the generic approach used to examine the…

Life and Utilization Criteria Identification in Design (LUCID). Volume II

DTIC Science & Technology

1981-10-01

AFWAL-.TR.412101 VOLUME Iff LIFE AND UTILIZATION CRITERIA IDENTIFICATION oIN DESIGN , VOLUME I[ SMcDonnell Aircraft Company SMcDonnell Douglas... design , a complexinteractive air- craft/engine design effort is conducted. The primary objective of the Life and Utilization Criteria Identification in... Design (LUCID) Program was to develop and demonstrate techniques which will aid in identifying, during conceptual design , balanced and consistent

Surveying the Maize community for their diversity and pedigree visualization needs to prioritize tool development and curation

PubMed Central

Braun, Bremen L.; Schott, David A.; Portwood, II, John L.; Schaeffer, Mary L.; Harper, Lisa C.; Gardiner, Jack M.; Cannon, Ethalinda K.; Andorf, Carson M.

2017-01-01

Abstract The Maize Genetics and Genomics Database (MaizeGDB) team prepared a survey to identify breeders’ needs for visualizing pedigrees, diversity data and haplotypes in order to prioritize tool development and curation efforts at MaizeGDB. The survey was distributed to the maize research community on behalf of the Maize Genetics Executive Committee in Summer 2015. The survey garnered 48 responses from maize researchers, of which more than half were self-identified as breeders. The survey showed that the maize researchers considered their top priorities for visualization as: (i) displaying single nucleotide polymorphisms in a given region for a given list of lines, (ii) showing haplotypes for a given list of lines and (iii) presenting pedigree relationships visually. The survey also asked which populations would be most useful to display. The following two populations were on top of the list: (i) 3000 publicly available maize inbred lines used in Romay et al. (Comprehensive genotyping of the USA national maize inbred seed bank. Genome Biol, 2013;14:R55) and (ii) maize lines with expired Plant Variety Protection Act (ex-PVP) certificates. Driven by this strong stakeholder input, MaizeGDB staff are currently working in four areas to improve its interface and web-based tools: (i) presenting immediate progenies of currently available stocks at the MaizeGDB Stock pages, (ii) displaying the most recent ex-PVP lines described in the Germplasm Resources Information Network (GRIN) on the MaizeGDB Stock pages, (iii) developing network views of pedigree relationships and (iv) visualizing genotypes from SNP-based diversity datasets. These survey results can help other biological databases to direct their efforts according to user preferences as they serve similar types of data sets for their communities. Database URL: https://www.maizegdb.org PMID:28605768

Evaluation of HiPHES convective reformer design alternatives. Phase 2, Final issue

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-08-01

Phase I Stone & Webster presented three potential design configurations for a ceramic-tubed steam-methane reformer. These were the Tube-Within-a-Tube (TWIT) design, the Once-Through design, and the Monolith design. Although the TWIT design configuration appeared to be the most viable, the inclusion of a more detailed examination of design alternatives for the HiPHES reformer was deemed appropriate for the Phase II program. Of particular concern was the length of the ceramic tubes required for the TWIT design. To assist in this evaluation, Stone & Webster established a Development Team consisting of specialists in the areas of heat transfer, ceramic materials, exchangermore » design, vessel design, and potential users. Stone & Webster reviewed the critical areas of concern for a ceramic convective reformer, evaluated competing design configurations, and presented the results to the Development Team. This report presents Stone & Webster`s evaluations and the comments and recommendations of the Development Team. This effort comprised the majority of Task 1 of Phase II of Stone & Webster`s HiPHES project. The design review was executed in parallel with the material coupon screening tests at BP America. The goal of both tasks was to confirm the materials selection and reformer design configuration so that the conditions for the tube and joint tests to be conducted at Oak Ridge National Laboratory (ORNL) could be specified. The ORNL tests are intended to evaluate the reformer design configuration and materials of construction used for the reformer design in Phase II, and to be used in the demonstration unit in Phase III. The Task 1 (Evaluation of Alternative Reformer Designs) effort has identified a preferred design configuration for the proposed ceramic reformer. Additional engineering and material evaluation work is necessary before an operating prototype can be designed.« less

System Design of a Natural Gas PEM Fuel Cell Power Plant for Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joe Ferrall, Tim Rehg, Vesna Stanic

2000-09-30

The following conclusions are made based on this analysis effort: (1) High-temperature PEM data are not available; (2) Stack development effort for Phase II is required; (3) System results are by definition preliminary, mostly due to the immaturity of the high-temperature stack; other components of the system are relatively well defined; (4) The Grotthuss conduction mechanism yields the preferred system characteristics; the Grotthuss conduction mechanism is also much less technically mature than the vehicle mechanism; (5) Fuel processor technology is available today and can be procured for Phase II (steam or ATR); (6) The immaturity of high-temperature membrane technology requiresmore » that a robust system design be developed in Phase II that is capable of operating over a wide temperature and pressure range - (a) Unpressurized or Pressurized PEM (Grotthuss mechanism) at 140 C, Highest temperature most favorable, Lowest water requirement most favorable, Pressurized recommended for base loaded operation, Unpressurized may be preferred for load following; (b) Pressurized PEM (vehicle mechanism) at about 100 C, Pressure required for saturation, Fuel cell technology currently available, stack development required. The system analysis and screening evaluation resulted in the identification of the following components for the most promising system: (1) Steam reforming fuel processor; (2) Grotthuss mechanism fuel cell stack operating at 140 C; (3) Means to deliver system waste heat to a cogeneration unit; (4) Pressurized system utilizing a turbocompressor for a base-load power application. If duty cycling is anticipated, the benefits of compression may be offset due to complexity of control. In this case (and even in the base loaded case), the turbocompressor can be replaced with a blower for low-pressure operation.« less

Floodplain Assessment for the Middle Los Alamos Canyon Aggregate Area Investigations in Technical Area 02 at Los Alamos National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hathcock, Charles Dean

The proposed action being assessed in this document occurs in TA-02 in the bottom of Los Alamos Canyon. The DOE proposes to conduct soil sampling at AOC 02-011 (d), AOC 02- 011(a)(ii), and SWMU 02-005, and excavate soils in AOC 02-011(a)(ii) as part of a corrective actions effort. Additional shallow surface soil samples (soil grab samples) will be collected throughout the TA-02 area, including within the floodplain, to perform ecotoxicology studies (Figures 1 and 2). The excavation boundaries in AOC 02-011(a)(ii) are slightly within the delineated 100-year floodplain. The project will use a variety of techniques for soil sampling andmore » remediation efforts to include hand/digging, standard hand auger/sampling, excavation using machinery such as backhoe and front end loader and small drill rig. Heavy equipment will traverse the floodplain and spoils piles will be staged in the floodplain within developed or previously disturbed areas (e.g., existing paved roads and parking areas). The project will utilize and maintain appropriate best management practices (BMPs) to contain excavated materials, and all pollutants, including oil from machinery/vehicles. The project will stabilize disturbed areas as appropriate at the end of the project.« less

Notice of release of 'Trailhead II' basin wildrye

USDA-ARS?s Scientific Manuscript database

'Trailhead II' basin wildrye [Leymus cinereus (Scribn. & Merr.) A. Love] is a tetraploid basin wildrye release for use in re-vegetation efforts on rangelands of western North America. Trailhead II is the result of two cycles of recurrent selection within the basin wildrye cultivar 'Trailhead' for r...

Simulation model for wind energy storage systems. Volume II. Operation manual. [SIMWEST code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warren, A.W.; Edsinger, R.W.; Burroughs, J.D.

1977-08-01

The effort developed a comprehensive computer program for the modeling of wind energy/storage systems utilizing any combination of five types of storage (pumped hydro, battery, thermal, flywheel and pneumatic). An acronym for the program is SIMWEST (Simulation Model for Wind Energy Storage). The level of detail of SIMWEST is consistent with a role of evaluating the economic feasibility as well as the general performance of wind energy systems. The software package consists of two basic programs and a library of system, environmental, and load components. Volume II, the SIMWEST operation manual, describes the usage of the SIMWEST program, the designmore » of the library components, and a number of simple example simulations intended to familiarize the user with the program's operation. Volume II also contains a listing of each SIMWEST library subroutine.« less

Aerosol-Radiation-Cloud Interactions in the South-East Atlantic: Model-Relevant Observations and the Beneficiary Modeling Efforts in the Realm of the EVS-2 Project ORACLES

NASA Technical Reports Server (NTRS)

Redemann, Jens

2018-01-01

Globally, aerosols remain a major contributor to uncertainties in assessments of anthropogenically-induced changes to the Earth climate system, despite concerted efforts using satellite and suborbital observations and increasingly sophisticated models. The quantification of direct and indirect aerosol radiative effects, as well as cloud adjustments thereto, even at regional scales, continues to elude our capabilities. Some of our limitations are due to insufficient sampling and accuracy of the relevant observables, under an appropriate range of conditions to provide useful constraints for modeling efforts at various climate scales. In this talk, I will describe (1) the efforts of our group at NASA Ames to develop new airborne instrumentation to address some of the data insufficiencies mentioned above; (2) the efforts by the EVS-2 ORACLES project to address aerosol-cloud-climate interactions in the SE Atlantic and (3) time permitting, recent results from a synergistic use of A-Train aerosol data to test climate model simulations of present-day direct radiative effects in some of the AEROCOM phase II global climate models.

PHASE I MATERIALS PROPERTY DATABASE DEVELOPMENT FOR ASME CODES AND STANDARDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ren, Weiju; Lin, Lianshan

2013-01-01

To support the ASME Boiler and Pressure Vessel Codes and Standard (BPVC) in modern information era, development of a web-based materials property database is initiated under the supervision of ASME Committee on Materials. To achieve efficiency, the project heavily draws upon experience from development of the Gen IV Materials Handbook and the Nuclear System Materials Handbook. The effort is divided into two phases. Phase I is planned to deliver a materials data file warehouse that offers a depository for various files containing raw data and background information, and Phase II will provide a relational digital database that provides advanced featuresmore » facilitating digital data processing and management. Population of the database will start with materials property data for nuclear applications and expand to data covering the entire ASME Code and Standards including the piping codes as the database structure is continuously optimized. The ultimate goal of the effort is to establish a sound cyber infrastructure that support ASME Codes and Standards development and maintenance.« less

Electrically Driven Thermal Management: Flight Validation, Experiment Development, Future Technologies

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2018-01-01

Electrically Driven Thermal Management is an active research and technology development initiative incorporating ISS technology flight demonstrations (STP-H5), development of Microgravity Science Glovebox (MSG) flight experiment, and laboratory-based investigations of electrically based thermal management techniques. The program targets integrated thermal management for future generations of RF electronics and power electronic devices. This presentation reviews four program elements: i.) results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched in February 2017 ii.) development of the Electrically Driven Liquid Film Boiling Experiment iii.) two University based research efforts iv.) development of Oscillating Heat Pipe evaluation at Goddard Space Flight Center.

The role of technology in reducing health care costs. Phase II and phase III.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cilke, John F.; Parks, Raymond C.; Funkhouser, Donald Ray

2004-04-01

In Phase I of this project, reported in SAND97-1922, Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. The effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements and an economic analysis model for development of care pathway costs for two conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Phases II and III of this project, which are presented in this report, were directed at detailing the parameters of telemedicine that influence care deliverymore » costs and quality. These results were used to identify and field test the communication, interoperability, and security capabilities needed for cost-effective, secure, and reliable health care via telemedicine.« less

Report of an Urban Education Reform Experiment: Problems and Promises. Section II: Project Evaluation. Supplement to the Final Report of the 5th Cycle Teacher Corps Project.

ERIC Educational Resources Information Center

Rippey, Robert M.

This document recounts the efforts of an urban college of education (the one at the University of Illinois/Chicago Circle) to develop a cooperative program in urban teacher education. It deals with the origin of the project, operational problems encountered, solutions attempted, critical functions of systematic evaluation. Also included are…

Identifying and Assessing Interaction Knowledge, Skills, and Attributes for Future Force Soldiers

DTIC Science & Technology

2007-05-01

Research Institute for the Behavioral and Social Sciences (ARI) SBIR request, the Army Interpersonal Skills Assessment ( AISA ) battery consists of five...Army evolves over the coming years, Soldiers will be placed in positions that require increasing interaction effectiveness. The goal of the AISA is...effective interpersonal KSAs may improve performance. In Phase II of this SBIR effort, the AISA battery underwent a full development cycle

Investigating the Fundamental Scientific Issues Affecting the Long-term Geologic Storage of Carbon Dioxide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spangler, Lee; Cunningham, Alfred; Barnhart, Elliot

2014-12-19

The Zero Emissions Research and Technology (ZERT) collaborative was formed to address basic science and engineering knowledge gaps relevant to geologic carbon sequestration. The original funding round of ZERT (ZERT I) identified and addressed many of these gaps. ZERT II has focused on specific science and technology areas identified in ZERT I that showed strong promise and needed greater effort to fully develop.

Automated Air Information Production System - Phase II.

DTIC Science & Technology

1980-10-01

Alphanumeric CRT terminals, 2 Gandalf Data Inc. Model LDS 250/3 56 Kbps synchronous short haul modems , 2 General Data Comm Industries TDM-1205 time...supplied encrypt/decrypt devices which would interface to the communications multiplexers supplied by Synectics. Synectics also supplied short haul modems ...During the development effort and throughput of the T&E period the high speed ( 56K bps) link would intermittently go out of synchronization. The problem

The process of moving from a regionally based cervical cytology biobank to a national infrastructure.

PubMed

Perskvist, Nasrin; Norlin, Loreana; Dillner, Joakim

2015-04-01

This article addresses the important issue of the standardization of the biobank process. It reports on i) the implementation of standard operating procedures for the processing of liquid-based cervical cells, ii) the standardization of storage conditions, and iii) the ultimate establishment of nationwide standardized biorepositories for cervical specimens. Given the differences in the infrastructure and healthcare systems of various county councils in Sweden, these efforts were designed to develop standardized methods of biobanking across the nation. The standardization of cervical sample processing and biobanking is an important and widely acknowledged issue. Efforts to address these concerns will facilitate better patient care and improve research based on retrospective and prospective collections of patient samples and cohorts. The successful nationalization of the Cervical Cytology Biobank in Sweden is based on three vital issues: i) the flexibility of the system to adapt to other regional systems, ii) the development of the system based on national collaboration between the university and the county councils, and iii) stable governmental financing by the provider, the Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI.se). We will share our experiences with biorepository communities to promote understanding of and advances in opportunities to establish a nationalized biobank which covers the healthcare of the entire nation.

Recent advances in the development of p21-activated kinase inhibitors.

PubMed

Coleman, Natalia; Kissil, Joseph

2012-04-01

The p21-activated kinases (PAKs) are downstream effectors of the small G-proteins of the Rac and cdc42 family and have been implicated as essential for cell proliferation and survival. Recent studies have also demonstrated the promise of PAKs as therapeutic targets in various types of cancers. The PAKs are divided into two major groups (group I and II) based on sequence similarities. Although the different roles the PAK groups might play are not well understood, recent efforts have focused on the identification of kinase inhibitors that can discriminate between the two groups. In this review these efforts and newly identified inhibitors will be described and future directions discussed.

Challenges of Antibacterial Discovery

PubMed Central

Silver, Lynn L.

2011-01-01

Summary: The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output of the effort. The major challenges fall into two areas: (i) proper target selection, particularly the necessity of pursuing molecular targets that are not prone to rapid resistance development, and (ii) improvement of chemical libraries to overcome limitations of diversity, especially that which is necessary to overcome barriers to bacterial entry and proclivity to be effluxed, especially in Gram-negative organisms. Failure to address these problems has led to a great deal of misdirected effort. PMID:21233508

The evolutionary pathway from anoxygenic to oxygenic photosynthesis examined by comparison of the properties of photosystem II and bacterial reaction centers.

PubMed

Allen, J P; Williams, J C

2011-01-01

In photosynthetic organisms, such as purple bacteria, cyanobacteria, and plants, light is captured and converted into energy to create energy-rich compounds. The primary process of energy conversion involves the transfer of electrons from an excited donor molecule to a series of electron acceptors in pigment-protein complexes. Two of these complexes, the bacterial reaction center and photosystem II, are evolutionarily related and structurally similar. However, only photosystem II is capable of performing the unique reaction of water oxidation. An understanding of the evolutionary process that lead to the development of oxygenic photosynthesis can be found by comparison of these two complexes. In this review, we summarize how insight is being gained by examination of the differences in critical functional properties of these complexes and by experimental efforts to alter pigment-protein interactions of the bacterial reaction center in order to enable it to perform reactions, such as amino acid and metal oxidation, observable in photosystem II.

The Open Cluster Chemical Abundances and Mapping (OCCAM) Survey: Optical Extension for Neutron Capture Elements

NASA Astrophysics Data System (ADS)

Melendez, Matthew; O'Connell, Julia; Frinchaboy, Peter M.; Donor, John; Cunha, Katia M. L.; Shetrone, Matthew D.; Majewski, Steven R.; Zasowski, Gail; Pinsonneault, Marc H.; Roman-Lopes, Alexandre; Stassun, Keivan G.; APOGEE Team

2017-01-01

The Open Cluster Chemical Abundance & Mapping (OCCAM) survey is a systematic survey of Galactic open clusters using data primarily from the SDSS-III/APOGEE-1 survey. However, neutron capture elements are very limited in the IR region covered by APOGEE. In an effort to fully study detailed Galactic chemical evolution, we are conducting a high resolution (R~60,000) spectroscopic abundance analysis of neutron capture elements for OCCAM clusters in the optical regime to complement the APOGEE results. As part of this effort, we present Ba II, La II, Ce II and Eu II results for a few open clusters without previous abundance measurements using data obtained at McDonald Observatory with the 2.1m Otto Struve telescope and Sandiford Echelle Spectrograph.This work is supported by an NSF AAG grant AST-1311835.

FutureGen 2.0 Pipeline and Regional Carbon Capture Storage Project - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burger, Chris; Wortman, David; Brown, Chris

The U.S. Department of Energy’s (DOE) FutureGen 2.0 Program involves two projects: (1) the Oxy-Combustion Power Plant Project and (2) the CO2 Pipeline and Storage Project. This Final Technical Report is focused on the CO2 Pipeline and Storage Project. The FutureGen 2.0 CO2 Pipeline and Storage Project evolved from an initial siting and project definition effort in Phase I, into the Phase II activity consisting permitting, design development, the acquisition of land rights, facility design, and licensing and regulatory approvals. Phase II also progressed into construction packaging, construction procurement, and targeted early preparatory activities in the field. The CO2 Pipelinemore » and Storage Project accomplishments were significant, and in some cases unprecedented. The engineering, permitting, legal, stakeholder, and commercial learnings substantially advance the nation’s understanding of commercial-scale CO2 storage in deep saline aquifers. Voluminous and significant information was obtained from the drilling and the testing program of the subsurface, and sophisticated modeling was performed that held up to a wide range of scrutiny. All designs progressed to the point of securing construction contracts or comfort letters attesting to successful negotiation of all contract terms and willing execution at the appropriate time all major project elements – pipeline, surface facilities, and subsurface – as well as operations. While the physical installation of the planned facilities did not proceed in part due to insufficient time to complete the project prior to the expiration of federal funding, the project met significant objectives prior to DOE’s closeout decision. Had additional time been available, there were no known, insurmountable obstacles that would have precluded successful construction and operation of the project. Due to the suspension of the project, site restoration activities were developed and the work was accomplished. The site restoration efforts are also documented in this report. All permit applications had been submitted to all agencies for those permits or approvals required prior to the start of project construction. Most of the requisite permits were received during Phase II. This report includes information on each permitting effort. Successes and lessons learned are included in this report that will add value to the next generation of carbon storage efforts.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Jingguang; Frenkel, Anatoly; Rodriguez, Jose

Synchrotron spectroscopies offer unique advantages over conventional techniques, including higher detection sensitivity and molecular specificity, faster detection rate, and more in-depth information regarding the structural, electronic and catalytic properties under in-situ reaction conditions. Despite these advantages, synchrotron techniques are often underutilized or unexplored by the catalysis community due to various perceived and real barriers, which will be addressed in the current proposal. Since its establishment in 2005, the Synchrotron Catalysis Consortium (SCC) has coordinated significant efforts to promote the utilization of cutting-edge catalytic research under in-situ conditions. The purpose of the current renewal proposal is aimed to provide assistance, andmore » to develop new sciences/techniques, for the catalysis community through the following concerted efforts: Coordinating the implementation of a suite of beamlines for catalysis studies at the new NSLS-II synchrotron source; Providing assistance and coordination for catalysis users at an SSRL catalysis beamline during the initial period of NSLS to NSLS II transition; Designing in-situ reactors for a variety of catalytic and electrocatalytic studies; Assisting experimental set-up and data analysis by a dedicated research scientist; Offering training courses and help sessions by the PIs and co-PIs.« less

Investigational drugs to treat methicillin-resistant Staphylococcus aureus

PubMed Central

Vuong, Cuong; Yeh, Anthony J; Cheung, Gordon YC; Otto, Michael

2016-01-01

Introduction Staphylococcus aureus remains one of the leading causes of morbidity and mortality worldwide. This is to a large extent due to antibiotic-resistant strains, in particular methicillin-resistant S. aureus (MRSA). While the toll of invasive MRSA infections appears to decrease in U.S. hospitals, the rate of community-associated MRSA infections remains constant and there is a surge of MRSA in many other countries. This situation calls for continuing if not increased efforts to find novel strategies to combat MRSA infections. Areas covered This review will provide an overview of current investigational antibiotics in clinical development (up to phase II), and of therapeutic antibodies and alternative drugs against S. aureus in preclinical and clinical development, including a short description of the mechanism of action and a presentation of microbiological and clinical data. Expert opinion Increased recent antibiotic development efforts and results from pathogenesis research have led to several new antibiotics and alternative drugs, as well as a more informed selection of targets for vaccination efforts against MRSA. This developing portfolio of novel anti-staphylococcal drugs will hopefully provide us with additional and more efficient ways to combat MRSA infections in the near future and prevent us from running out of treatment options, even if new resistances arise. PMID:26536498

An Authoring System for Creating Computer-Based Role-Performance Trainers.

ERIC Educational Resources Information Center

Guralnick, David; Kass, Alex

This paper describes a multimedia authoring system called MOPed-II. Like other authoring systems, MOPed-II reduces the time and expense of producing end-user applications by eliminating much of the programming effort they require. However, MOPed-II reflects an approach to authoring tools for educational multimedia which is different from most…

Development of luminescent sensors based on transition metal complexes for the detection of nitroexplosives.

PubMed

Sathish, Veerasamy; Ramdass, Arumugam; Velayudham, Murugesan; Lu, Kuang-Lieh; Thanasekaran, Pounraj; Rajagopal, Seenivasan

2017-12-12

The detection of chemical explosives is a major area of research interest and is essential for the military as well as homeland security to counter the catastrophic effects of global terrorism. In recent years, tremendous effort has been devoted to the development of luminescent materials for the detection of explosives in the vapor, solution, and solid states with a high degree of selectivity and sensitivity and a rapid response time. Apart from the wide range of organic fluorescent chemosensors, transition metal complexes play a prominent role in the sensing of nitroaromatic explosives owing to their rich photophysical characteristics. This review briefly summarizes the salient features of the design and preparation of transition metal (Zn(ii), Ir(iii), Pd(ii), Pt(ii), Re(i) and Ru(ii)) complexes/metallacycles/metallosupramolecules with emphasis on their photophysical properties, sensing behavior, mechanism of action, and the driving forces for detecting explosives and future prospects and challenges. Most of the probes that have been reported to date act as "turn-off" luminescent sensors because their emission (intensity, lifetime, and quantum yield) is eventually quenched upon sensing with nitroaromatic compounds (NACs) through photo-induced electron or energy transfer. These unique properties of transition metal complexes in response to explosives open up new vistas for the development of real world applications such as on-site detection, in-field security, forensic research, etc.

Using MOF-74 for Hg{sup 2+} removal from ultra-low concentration aqueous solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiong, Yang Yang; Li, Jian Qiang; Gong, Le Le

Mercury (Hg{sup 2+}) ions have very high toxicity and widely spread as environmental pollutants. At present, many efforts have been taken to remove the hazardous materials of mercury(II) by adsorption, and it is highly desirable to develop a novel adsorbent with high adsorptive capacities. However it is still a big challenge to remove the ultra-low-concentration mercury ions from water. In this paper, MOF-74-Zn is explored for such function, showing high removal rate of Hg(II) from water without any pretreatment, especially for the ultra-trace Hg(II) ions in the ppb magnitude with the removal rate reaching to 54.48%, 69.71%, 72.26% when themore » initial concentration of Hg(II) is 20ppb, 40ppb, 50ppb, respectively. - Graphical abstract: The absorption of mercury ions on MOF-74-Zn is due to somewhat weak interactions between MOF skeleton that is composed of carboxylate and hydroxy group and Hg2+ ions. - Highlights: • MOF-74-Zn shows high removal rate of Hg(II) from water without any pretreatment. • The MOF-74-Zn has a notable performance at ultra-low concentration of Hg(II). • MOF-74-Zn shows the potential for Hg(II) removal from industrial waste water.« less

Final Report for Phase II Study: Prototyping the Sketch Planning Visualization Tool for Non-Motorized Travel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hwang, Ho-Ling; Wilson, Daniel W; Reuscher, Tim

To further examine how factors such as those identified from the Phase I NMT study, and the modeling framework developed under that effort could be applied to local/regional level planning activities, FHWA decided to pursue a Phase II study. It was determined that a small geographic area with more detailed local data would be necessary. Although Washington D.C. was not one of the 2009 NHTS add-ons, it did conduct a household travel survey of 11,000 households in 2007-2008. The National Capital Region Transportation Planning Board at the Metropolitan Washington Council of Governments (MWCOG) conducted the household travel survey. The datamore » coverage under the MWCOG survey is much higher than that of the NHTS. As a part of the Phase II study, a prototype of a Geographic Information System (GIS)-based sketch planning visualization tool was also to be developed. The intent was to use a neighborhood in the Washington D.C. region as a case study for this prototype application.« less

Explaining Asian Americans' academic advantage over whites.

PubMed

Hsin, Amy; Xie, Yu

2014-06-10

The superior academic achievement of Asian Americans is a well-documented phenomenon that lacks a widely accepted explanation. Asian Americans' advantage in this respect has been attributed to three groups of factors: (i) socio-demographic characteristics, (ii) cognitive ability, and (iii) academic effort as measured by characteristics such as attentiveness and work ethic. We combine data from two nationally representative cohort longitudinal surveys to compare Asian-American and white students in their educational trajectories from kindergarten through high school. We find that the Asian-American educational advantage is attributable mainly to Asian students exerting greater academic effort and not to advantages in tested cognitive abilities or socio-demographics. We test explanations for the Asian-white gap in academic effort and find that the gap can be further attributed to (i) cultural differences in beliefs regarding the connection between effort and achievement and (ii) immigration status. Finally, we highlight the potential psychological and social costs associated with Asian-American achievement success.

Non-Invasive Pneumothorax Detector Final Report CRADA No. TC02110.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, J. T.; Purcell, R.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and ElectroSonics Medical Inc. (formerly known as BIOMEC, Inc.), to develop a non-invasive pneumothorax detector based upon the micropower impulse radar technology invented at LLNL. Under a Work for Others Subcontract (L-9248), LLNL and ElectroSonics successfully demonstrated the feasibility of a novel device for non-invasive detection of pneumothorax for emergency and long-term monitoring. The device is based on Micropower Impulse Radar (MIR) Ultra Wideband (UWB) technology. Phase I experimental results were promising, showing that a pneumothorax volume even asmore » small as 30 ml was clearly detectable from the MIR signals. Phase I results contributed to the award of a National Institute of Health (NIH) SBIR Phase II grant to support further research and development. The Phase II award led to the establishment of a LLNL/ElectroSonics CRADA related to Case No. TC02045.0. Under the subsequent CRADA, LLNL and ElectroSonics successfully demonstrated the feasibility of the pneumothorax detection in human subject research trials. Under this current CRADA TC02110.0, also referred to as Phase II Type II, the project scope consisted of seven tasks in Project Year 1; five tasks in Project Year 2; and four tasks in Project Year 3. Year 1 tasks were aimed toward the delivery of the pneumothorax detector design package for the pre-production of the miniaturized CompactFlash dockable version of the system. The tasks in Project Years 2 and 3 critically depended upon the accomplishments of Task 1. Since LLNL’s task was to provide subject matter expertise and performance verification, much of the timeline of engagement by the LLNL staff depended upon the overall project milestones as determined by the lead organization ElectroSonics. The scope of efforts were subsequently adjusted accordingly to commensurate with funding availability.« less

Computerized Adaptive Testing (CAT): A User Manual

DTIC Science & Technology

1984-03-12

NPRDC TR 84-32 COMPUTERIZED ADAPTIVE TESTING ( CAT ): A USER MANUAL Susan Hardwick Lawrence Eastman Ross Cooper Rehab Group, Incorporated San...a ~EI’IOD COVIRED COMPUTERIZED ADAPTIVE TESTING ( CAT ) Final Report Aug 1981-June 1982 A USER MANUAL 1. ~l:l’t,ORMINCI ORCI. RE~ORT NUM.I:R 62-83...II nee• .. _, entl ldentll)’ ,,. llloclr _,.,) A joint-service effort is underway to develop a computerized adaptive testing ( CAT ) system and to

Approximate Confidence Limit Procedures for Complex Systems

DTIC Science & Technology

1991-09-01

requirements for the degree of MASTER OF SCIENCE IN OPERATIONS RESEARCH from the NAVAL POSTGRADUATE SCHOOL September 1991 A uthor...34 YEE, Kah-Chee Approved by: ? )t. 7 " ’& W. M. WOODS, Thesis Advisor R. R. READ, Second Reader P. PURDE, airman Department of Operations Research ii...cautioned that the computer programs developed in this research may not have been exercised for all cases of interest. While every effort has been made

Problems and perspectives in paraplegia

NASA Technical Reports Server (NTRS)

Nashold, B.

1974-01-01

Improved clinical treatment of the paraplegic, developed during World War II, has reduced the overall mortality rate from close to 100 percent to 30 percent. Despite major clinical improvements, mainly in treatment of the acute phase of paraplegia, and despite greater rehabilitation efforts, the spinal injured person is never rehabilitated in the sense that he reaches an optimum and stays there. He is always exposed to the constant threat of deterioration of his physiological, sociological, and psychological state.

Ultraviolet Communication for Medical Applications

DTIC Science & Technology

2013-06-01

sky was clear and no moonlight was visible during testing. There was light fog and high pollen count (9 grains per m3), and relative humidity was...improved LED light source was evaluated outdoors using the test bench system at a range of 50 m, and received photon counts were consistent with...bench system at a range of 50 m, and received photon counts were consistent with medium data rate communication. Future Phase II efforts will develop

A Demonstration and Analysis of Requirements for Maritime Navigation Planning.

DTIC Science & Technology

1998-03-01

it the highest and 0-4 and above the lowest. Once again, the value added by grouping the data and comparing may be nothing...purpose behind a prototype is to ascertain user requirements. It should be created rapidly to speed up the system development life cycle ( SDLC ). Since...system is contained in Chapter II, Section B. 3. Internet to Sea (SEANET) Program The SeaNet Project is a collaborative effort to bring the

Superpave in-situ stress/strain investigation--phase II : vol. II, materials characterization.

DOT National Transportation Integrated Search

2009-05-01

The characterization of materials is an intergral part of the overall effort to validate the Superpave system and to calibrate the performance prdeictionmodels for the environmental conditions observed in the Commonwealth of Pennsylvania.

Morristown Alternative Transportation Study Phase II.

DOT National Transportation Integrated Search

2005-10-14

This report summarizes the Phase II planning effort conducted by the park and the US Department of Transportation's Volpe Center (the Volpe Center) to articulate a viable park-community pilot transit service for Morristown National Historical Park. M...

Scratched: World War II Airborne Operations That Never Happened

DTIC Science & Technology

2014-05-22

Approved for Public Release; Distribution is Unlimited SCRATCHED: WORLD WAR II AIRBORNE OPERATIONS THAT NEVER HAPPENED A Monograph by...2. REPORT TYPE Master’s Thesis 3. DATES COVERED (From - To) JUN 2013-MAY 2014 4. TITLE AND SUBTITLE Scratched: World War II Airborne...Maastricht gap, to get Allied troops through the West Wall. For numerous reasons, the overall Allied airborne effort of World War II provided mixed

Correlation of Orthodontic Treatment by Fixed or Myofunctional Appliances and Periodontitis: A Retrospective Study.

PubMed

Sharma, Kanchan; Mangat, Sukhpreet; Kichorchandra, Modi S; Handa, Akash; Bindhumadhav, Suresh; Meena, Meenakshi

2017-04-01

Malocclusion plays an important role in the development of periodontitis. Thus, by treating malocclusion, a good gingival health can be achieved. This study was conducted to establish the correlation between orthodontic tooth movement and periodontitis. This is a retrospective study conducted on 220 patients who underwent orthodontic treatment for malocclusion. They were divided into two groups: Group I patients were treated with fixed orthodontics, while group II patients received myofunctional appliances. The value for plaque, gingival recession, and tooth mobility significantly increased in group I patients. However, the difference was statistically nonsignificant in group II patients. The authors concluded that there is correlation between malocclusion and periodontitis. Malocclusion leads to periodontitis. Malocclusion is the main reason for the development of poor periodontal health. Combined effort has to be played by both periodontist and orthodontist for the treatment of various orthodontic-periodontal problems.

APT, The Phase I tool for HST Cycle 12

NASA Astrophysics Data System (ADS)

Blacker, Brett S.; Bertch, Maria; Curtis, Gary; Douglas, Robert E., Jr.; Krueger, Anthony P.

2002-12-01

In the continuing effort to streamline our systems and improve service to the science community, the Space Telescope Science Institute (STScI) is developing and releasing, APT The Astronomer’s Proposal Tool as the new interface for Hubble Space Telescope (HST) Phase I and Phase II proposal submissions for HST Cycle 12. APT, was formerly called the Scientist’s Expert Assistant (SEA), which started as a prototype effort to try and bring state of the art technology, more visual tools and power into the hands of proposers so that they can optimize the scientific return of their programs as well as HST. Proposing for HST and other missions, consists of requesting observing time and/or archival research funding. This step is called Phase I, where the scientific merit of a proposal is considered by a community based peer-review process. Accepted proposals then proceed thru Phase II, where the observations are specified in sufficient detail to enable scheduling on the telescope. In this paper, we will present our concept and implementation plans for our Phase I development and submission tool, APT. More importantly, we will go behind the scenes and discuss why it’s important for the Science Policies Division (SPD) and other groups at the STScI to have a new submission tool and submission output products. This paper is an update of the status of the HST Phase I Proposal Processing System that was described in the published paper “A New Era for HST Phase I Development and Submission.”

Five years from the great 2010 Tsunami in Chile: learning from multi-hazard disasters and improving resileincy

NASA Astrophysics Data System (ADS)

Cienfuegos, R.; Gonzalez, G.; Repetto, P.; Cipriano, A.; Moris, R.; Catalan, P. A.; Guic, E.; Martin, J. C. D. L. L.

2016-12-01

The Research Center for Integrated Natural Hazards Management (CIGIDEN) has developed in recent years (supported by the Fondap/Conicyt Excellence in research center's program) active efforts to connect science and public institutions in charge of disaster management in Chile. We have been able to reach in particular the National Emergency Office (ONEMI) and the National Hydrographic and Oceanographic Naval Service (SHOA), and develop joint specific programs that have been mutually beneficial both for research enrichment and the operation of the emergency response system. Through these efforts, also supplemented by other Chilean and International research institutions, we analyzed together issues and challenges from the systemic failure experienced by the emergency system in Chile after the 2010 earthquake and tsunami. In this talk we will review some of the main collaboration actions and their outcomes, connecting them to the extreme events that impacted Chile in 2015 (earthquakes, tsunamis, storm waves, and flash floods). In particular we will describe the effort that CIGIDEN has developed i) with ONEMI in developing instruments to assess community preparedness and awareness and to understand tsunami evacuation behaviors; and ii) with SHOA to develop a new Integrated Decision Support System for Tsunami alerting that is being transferred to SHOA in September 2015, and was successfully tested offline during the September 16th, 2015, tsunami.

Forthcoming ethical issues in biological psychiatry.

PubMed

Helmchen, Hanfried

2005-01-01

Ethical issues in biological psychiatry are framed by (i) progress in the neurosciences, and (ii) a changing socio-cultural context. With regard to forthcoming neurotechniques to modify specifically defined brain functions by pharmacological substances with selective effects, by activating neuroplasticity including neurogenesis, or by implantation of neuronal tissues or computer-brain interfaces, etc., ethical problems will develop (i) at the border between therapy of diseases and enhancement of abilities in healthy people with regard to effects on society (e.g., social justice: equal access, loss of societal diversity) as well as on human value systems (e.g., personality, efforts, conditio humana), and (ii) at the border between the medical system and the wellness market with regard to financing what by whom? Ethical dilemmas in psychiatry develop (i) between the individual's best and the common good (demanded from outside medicine), (ii) among different ethical principles (inside medicine), iii) if solutions are influenced by personal reasons without observing ethical principles. Ethical guidelines are necessary for ethical orientation, but may protect against misconduct only (i) if psychiatrists are educated in ethics and (ii) if psychiatric acting is under continuous debate (by ethical review boards or the public). Thus, if we psychiatrists will become ethically sensitive by reflecting and perhaps solving our current ethical dilemmas we will be prepared to deal with forthcoming ethical issues in biological psychiatry.

Technology transfer package on seismic base isolation - Volume II

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-02-14

This Technology Transfer Package provides some detailed information for the U.S. Department of Energy (DOE) and its contractors about seismic base isolation. Intended users of this three-volume package are DOE Design and Safety Engineers as well as DOE Facility Managers who are responsible for reducing the effects of natural phenomena hazards (NPH), specifically earthquakes, on their facilities. The package was developed as part of DOE's efforts to study and implement techniques for protecting lives and property from the effects of natural phenomena and to support the International Decade for Natural Disaster Reduction. Volume II contains the proceedings for the Shortmore » Course on Seismic Base Isolation held in Berkeley, California, August 10-14, 1992.« less

The Intelligent Flight Control Program (IFCS)

NASA Technical Reports Server (NTRS)

2004-01-01

This is the closeout report for the Research Cooperative Agreement NCC4-00130 of accomplishments for the Intelligent Flight Control System (IFCS) Project. It has been a pleasure working with NASA and NASA partners as we strive to meet the goals of this research initiative. ISR was engaged in this Research Cooperative Agreement beginning 01 January 2003 and ending 31 January 2004. During this time ISR conducted efforts towards development of the ARTS II Computer Software Configuration Item (CSCI) version 4.0 by performing or developing the following: 1) Requirements Definition; 2) Software Design and Development; 3) Hardware In the Loop Simulation; 4) Unit Level testing; 5) Documentation.

Predicting Software Assurance Using Quality and Reliability Measures

DTIC Science & Technology

2014-12-01

errors are not found in unit testing . The rework effort to correct requirement and design problems in later phases can be as high as 300 to 1,000...Literature 31 Appendix B: Quality Cannot Be Tested In 35 Bibliography 38 CMU/SEI-2014-TN-026 | ii CMU/SEI-2014-TN-026 | iii List of Figures...Removal Densities During Development 10 Figure 8: Quality and Security-Focused Workflow 14 Figure 9: Testing Reliability Results for the Largest Project

Research and Operational Support for the Study of Military Relevant Infectious Diseases of Interest to United States and Royal Thai Government

DTIC Science & Technology

2006-01-01

in progress 8 PvDBP Polymorphisms Study completed; publication in progress 9 Tafenoquine Cure /Radical Cure Dose Ranging NIH In life completed Jan...and II, as possibly phase III testing. We will continue efforts for tafenoquine development, especially towards an indication of radical cure for...disease (prophylaxis) and to cure the infection (therapeutic). Antimalarial drug screening in the rhesus monkey model is very effective for making

The medical care system of Hungary.

PubMed

Raffel, N K; Raffel, M W

1988-01-01

Medical care in Hungary has made significant progress since World War II in spite of other social priorities which have limited financial support of the health system. A shortage of hard currency in a high technological era is now having a particularly severe adverse impact on further development. Decentralized administration and local finance have, however, provided some room for progress. Preventive efforts are hampered by a deeply entrenched life style which is not conducive to improving the population's health status.

A Case Study of the F-20 Tigershark

DTIC Science & Technology

1987-06-01

RAND Graduate School. This paper was prepared for the Spring 1987 R &D and Systems Acquisition Workshop led by George Donohue and Michael Rich. - II1...however, disagreement about why this was so. This paper examines the F-20 program from both a research and development ( R &D) and a marketing perspective...Northrop considers the F-20 R &D effort to have been successful. This examination leads us to discuss the problematic issue of finding and using

ESP: Economics of Shipyard Painting, Bid Estimating Transfer Study

DTIC Science & Technology

1993-11-10

Estimating Transfer Study Final Report i EXECUTIVE SUMMARY During Phase I of the “Economics of Shipyard Painting” project, it became evident that detail...an SP-3 panel directive to establish a 2nd phase of the “Economics of Shipyard Painting” focussed on applying the detailed data collected in Phase I to...bid-stage estimating. During Phase II, a program was developed that worked in tandem with the detailed data collection effort laid out in Phase I

Automotive Stirling engine systems development

NASA Technical Reports Server (NTRS)

Richey, A. E.

1984-01-01

The objective of the Automotive Stirling Engine (ASE) program is to develop a Stirling engine for automotive use that provides a 30 percent improvement in fuel economy relative to a comparable internal-combustion engine while meeting emissions goals. This paper traces the engine systems' development efforts focusing on: (1) a summary of engine system performance for all Mod I engines; (2) the development, program conducted for the upgraded Mod I; and (3) vehicle systems work conducted to enhance vehicle fuel economy. Problems encountered during the upgraded Mod I test program are discussed. The importance of the EPA driving cycle cold-start penalty and the measures taken to minimize that penalty with the Mod II are also addressed.

Plasma Science and Innovation Center at Washington, Wisconsin, and Utah State: Final Scientific Report for the University of Wisconsin-Madison

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sovinec, Carl R.

The University of Wisconsin-Madison component of the Plasma Science and Innovation Center (PSI Center) contributed to modeling capabilities and algorithmic efficiency of the Non-Ideal Magnetohydrodynamics with Rotation (NIMROD) Code, which is widely used to model macroscopic dynamics of magnetically confined plasma. It also contributed to the understanding of direct-current (DC) injection of electrical current for initiating and sustaining plasma in three spherical torus experiments: the Helicity Injected Torus-II (HIT-II), the Pegasus Toroidal Experiment, and the National Spherical Torus Experiment (NSTX). The effort was funded through the PSI Center's cooperative agreement with the University of Washington and Utah State University overmore » the period of March 1, 2005 - August 31, 2016. In addition to the computational and physics accomplishments, the Wisconsin effort contributed to the professional education of four graduate students and two postdoctoral research associates. The modeling for HIT-II and Pegasus was directly supported by the cooperative agreement, and contributions to the NSTX modeling were in support of work by Dr. Bickford Hooper, who was funded through a separate grant. Our primary contribution to model development is the implementation of detailed closure relations for collisional plasma. Postdoctoral associate Adam Bayliss implemented the temperature-dependent effects of Braginskii's parallel collisional ion viscosity. As a graduate student, John O'Bryan added runtime options for Braginskii's models and Ji's K2 models of thermal conduction with magnetization effects and thermal equilibration. As a postdoctoral associate, O'Bryan added the magnetization effects for ion viscosity. Another area of model development completed through the PSI-Center is the implementation of Chodura's phenomenological resistivity model. Finally, we investigated and tested linear electron parallel viscosity, leveraged by support from the Center for Extended Magnetohydrodynamic Modeling (CEMM). Work on algorithmic efficiency improved NIMROD's element-based computations. We reordered arrays and eliminated a level of looping for computations over the data points that are used for numerical integration over elements. Moreover, the reordering allows fewer and larger communication calls when using distributed-memory parallel computation, thereby avoiding a data starvation problem that limited parallel scaling over NIMROD's Fourier components for the periodic coordinate. Together with improved parallel preconditioning, work that was supported by CEMM, these developments allowed NIMROD's first scaling to over 10,000 processor cores. Another algorithm improvement supported by the PSI Center is nonlinear numerical diffusivities for implicit advection. We also developed the Stitch code to enhance the flexibility of NIMROD's preprocessing. Our simulations of HIT-II considered conditions with and without fluctuation-induced amplification of poloidal flux, but our validation efforts focused on conditions without amplification. A significant finding is that NIMROD reproduces the dependence of net plasma current as the imposed poloidal flux is varied. The modeling of Pegasus startup from localized DC injectors predicted that development of a tokamak-like configuration occurs through a sequence of current-filament merger events. Comparison of experimentally measured and numerically computed cross-power spectra enhance confidence in NIMROD's simulation of magnetic fluctuations; however, energy confinement remains an open area for further research. Our contributions to the NSTX study include adaptation of the helicity-injection boundary conditions from the HIT-II simulations and support for linear analysis and computation of 3D current-driven instabilities.« less

A physiome interoperability roadmap for personalized drug development

PubMed Central

2016-01-01

The goal of developing therapies and dosage regimes for characterized subgroups of the general population can be facilitated by the use of simulation models able to incorporate information about inter-individual variability in drug disposition (pharmacokinetics), toxicity and response effect (pharmacodynamics). Such observed variability can have multiple causes at various scales, ranging from gross anatomical differences to differences in genome sequence. Relevant data for many of these aspects, particularly related to molecular assays (known as ‘-omics’), are available in online resources, but identification and assignment to appropriate model variables and parameters is a significant bottleneck in the model development process. Through its efforts to standardize annotation with consequent increase in data usability, the human physiome project has a vital role in improving productivity in model development and, thus, the development of personalized therapy regimes. Here, we review the current status of personalized medicine in clinical practice, outline some of the challenges that must be overcome in order to expand its applicability, and discuss the relevance of personalized medicine to the more widespread challenges being faced in drug discovery and development. We then review some of (i) the key data resources available for use in model development and (ii) the potential areas where advances made within the physiome modelling community could contribute to physiologically based pharmacokinetic and physiologically based pharmacokinetic/pharmacodynamic modelling in support of personalized drug development. We conclude by proposing a roadmap to further guide the physiome community in its on-going efforts to improve data usability, and integration with modelling efforts in the support of personalized medicine development. PMID:27051513

Adhesive Pili in UTI Pathogenesis and Drug Development.

PubMed

Spaulding, Caitlin N; Hultgren, Scott J

2016-03-15

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and biophysical basis of host-pathogen interactions; (ii) consequences of the molecular cross-talk at the host pathogen interface in terms of disease progression; and (iii) pathophysiology of UTIs is leading to efforts to translate this knowledge into novel therapeutics to treat and prevent these infections.

Adhesive Pili in UTI Pathogenesis and Drug Development

PubMed Central

Spaulding, Caitlin N.; Hultgren, Scott J.

2016-01-01

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting 150 million people each year worldwide. High recurrence rates and increasing antimicrobial resistance among uropathogens are making it imperative to develop alternative strategies for the treatment and prevention of this common infection. In this Review, we discuss how understanding the: (i) molecular and biophysical basis of host-pathogen interactions; (ii) consequences of the molecular cross-talk at the host pathogen interface in terms of disease progression; and (iii) pathophysiology of UTIs is leading to efforts to translate this knowledge into novel therapeutics to treat and prevent these infections. PMID:26999218

NASA Software Cost Estimation Model: An Analogy Based Estimation Model

NASA Technical Reports Server (NTRS)

Hihn, Jairus; Juster, Leora; Menzies, Tim; Mathew, George; Johnson, James

2015-01-01

The cost estimation of software development activities is increasingly critical for large scale integrated projects such as those at DOD and NASA especially as the software systems become larger and more complex. As an example MSL (Mars Scientific Laboratory) developed at the Jet Propulsion Laboratory launched with over 2 million lines of code making it the largest robotic spacecraft ever flown (Based on the size of the software). Software development activities are also notorious for their cost growth, with NASA flight software averaging over 50% cost growth. All across the agency, estimators and analysts are increasingly being tasked to develop reliable cost estimates in support of program planning and execution. While there has been extensive work on improving parametric methods there is very little focus on the use of models based on analogy and clustering algorithms. In this paper we summarize our findings on effort/cost model estimation and model development based on ten years of software effort estimation research using data mining and machine learning methods to develop estimation models based on analogy and clustering. The NASA Software Cost Model performance is evaluated by comparing it to COCOMO II, linear regression, and K-­ nearest neighbor prediction model performance on the same data set.

Java-based Graphical User Interface for MAVERIC-II

NASA Technical Reports Server (NTRS)

Seo, Suk Jai

2005-01-01

A computer program entitled "Marshall Aerospace Vehicle Representation in C II, (MAVERIC-II)" is a vehicle flight simulation program written primarily in the C programming language. It is written by James W. McCarter at NASA/Marshall Space Flight Center. The goal of the MAVERIC-II development effort is to provide a simulation tool that facilitates the rapid development of high-fidelity flight simulations for launch, orbital, and reentry vehicles of any user-defined configuration for all phases of flight. MAVERIC-II has been found invaluable in performing flight simulations for various Space Transportation Systems. The flexibility provided by MAVERIC-II has allowed several different launch vehicles, including the Saturn V, a Space Launch Initiative Two-Stage-to-Orbit concept and a Shuttle-derived launch vehicle, to be simulated during ascent and portions of on-orbit flight in an extremely efficient manner. It was found that MAVERIC-II provided the high fidelity vehicle and flight environment models as well as the program modularity to allow efficient integration, modification and testing of advanced guidance and control algorithms. In addition to serving as an analysis tool for techno logy development, many researchers have found MAVERIC-II to be an efficient, powerful analysis tool that evaluates guidance, navigation, and control designs, vehicle robustness, and requirements. MAVERIC-II is currently designed to execute in a UNIX environment. The input to the program is composed of three segments: 1) the vehicle models such as propulsion, aerodynamics, and guidance, navigation, and control 2) the environment models such as atmosphere and gravity, and 3) a simulation framework which is responsible for executing the vehicle and environment models and propagating the vehicle s states forward in time and handling user input/output. MAVERIC users prepare data files for the above models and run the simulation program. They can see the output on screen and/or store in files and examine the output data later. Users can also view the output stored in output files by calling a plotting program such as gnuplot. A typical scenario of the use of MAVERIC consists of three-steps; editing existing input data files, running MAVERIC, and plotting output results.

The Heliopause Electrostatic Rapid Transit System (HERTS) Design, Trades, and Analyses Performed in the First Year of a Two Year Investigation

NASA Technical Reports Server (NTRS)

Wiegmann, Bruce M.

2016-01-01

The Heliopause Electrostatic Rapid Transit System (HERTS)1 was one of the seven total Phase II NASA Innovative Advanced Concepts (NIAC) that was down-selected in 2015 for continued funding and research. In Phase I we learned that a spacecraft propelled by an Electric Sail (E-Sail) can travel great astronomical distances, such as to the Heliopause region of the solar system (approx.100 to 120 AU) in approximately one quarter of the time (10 years) versus the time it took the Voyager spacecraft launched in 1977 (36 years). The current work within the Phase II NIAC effort builds upon the work that was done in the Phase I NIAC and is focused on: 1) Testing of plasma interaction with a charged wire in a unique MSFC test chamber, 2) Development of a Particle-in-Cell (PIC) models that are validated in the plasma testing and used to extrapolate to the E-Sail propulsion system design. 3) Further down select of a wire deployment and control approach from those narrowed down in the Phase I effort. This paper will document the findings to date (June, 2016) of the above focused areas.

Explaining Asian Americans’ academic advantage over whites

PubMed Central

Hsin, Amy; Xie, Yu

2014-01-01

The superior academic achievement of Asian Americans is a well-documented phenomenon that lacks a widely accepted explanation. Asian Americans’ advantage in this respect has been attributed to three groups of factors: (i) socio-demographic characteristics, (ii) cognitive ability, and (iii) academic effort as measured by characteristics such as attentiveness and work ethic. We combine data from two nationally representative cohort longitudinal surveys to compare Asian-American and white students in their educational trajectories from kindergarten through high school. We find that the Asian-American educational advantage is attributable mainly to Asian students exerting greater academic effort and not to advantages in tested cognitive abilities or socio-demographics. We test explanations for the Asian–white gap in academic effort and find that the gap can be further attributed to (i) cultural differences in beliefs regarding the connection between effort and achievement and (ii) immigration status. Finally, we highlight the potential psychological and social costs associated with Asian-American achievement success. PMID:24799702

Development of a universally applicable household food insecurity measurement tool: process, current status, and outstanding issues.

PubMed

Swindale, Anne; Bilinsky, Paula

2006-05-01

The United States Public Law 480 Title II food aid program is the largest U.S. government program directed at reducing hunger, malnutrition, and food insecurity in the developing world. USAID and Title II implementing partners face challenges in measuring the success of Title II programs in reducing household food insecurity because of the technical difficulty and cost of collecting and analyzing data on traditional food security indicators, such as per capita income and caloric adequacy. The Household Food Insecurity Access Scale (HFIAS) holds promise as an easier and more user-friendly approach for measuring the access component of household food security. To support the consistent and comparable collection of the HFIAS, efforts are under way to develop a guide with a standardized questionnaire and data collection and analysis instructions. A set of domains have been identified that is deemed to capture the universal experience of the access component of household food insecurity across countries and cultures. Based on these domains, a set of questions has been developed with wording that is deemed to be universally appropriate, with minor adaptation to local contexts. These underlying suppositions, based on research in multiple countries, are being verified by potential users of the guide. The key remaining issue relates to the process for creating a categorical indicator of food insecurity status from the HFIAS.

75 FR 25313 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

... (Financial Statement) reviewed or audited by an independent certified public accountant; (ii) Single Audit A... financial statement that has been audited by an independent certified public accountant; (ii) an ILR... of its continuing effort to reduce paperwork and respondent burden, invites the general public and...

Plasma Switch Development.

DTIC Science & Technology

1984-06-08

Appendix II), the progress to date will be detailed here. II° K -BEAM CONTROLLED SWITCH The EBCS is an opening switch concept that has the potential for...such plasma in ᝺ uis. To accurately assess the viability of this scheme, more effort than what was provided to date is required. 0 00 LL k CCj2 E - w...1962 e+A* -A +A (2) ... 2OOOz t~ -- whs A is, in enera, any positive molecular ion (simple or cluster ) of species A. We define the effective rate at

Mercury Phase II Study - Mercury Behavior across the High-Level Waste Evaporator System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bannochie, C. J.; Crawford, C. L.; Jackson, D. G.

2016-06-17

The Mercury Program team’s effort continues to develop more fundamental information concerning mercury behavior across the liquid waste facilities and unit operations. Previously, the team examined the mercury chemistry across salt processing, including the Actinide Removal Process/Modular Caustic Side Solvent Extraction Unit (ARP/MCU), and the Defense Waste Processing Facility (DWPF) flowsheets. This report documents the data and understanding of mercury across the high level waste 2H and 3H evaporator systems.

International Methane Hydrate Research and Development Workshop (6th) held in Bergen, Norway on May 13-15, 2008

DTIC Science & Technology

2009-07-22

Quantification Global Synthesis National and International Collaboration Gulf of Mexico JIP Mallik ODP 204, IODP 311 North Slope, AK India ODP 164...permafrost regions that hydrates are being studied include: • 1. Mallik Wells • 2. Arctic slope to Wainwright Alaska • 3. May be Russian effort in...commercial exploitation from arctic hydrates can be a reality? Are there any incitements for international collaboration beyound Mallik II and other ongoing

Non-Adiabatic Atomic Transitions: Computational Cross Section Calculations of Alkali Metal-Noble Gas Collisions

DTIC Science & Technology

2011-09-01

there a one time transfer of prob- ability between Coriolis coupled states. One possible way to answer this question would be to literally create and... time -dependent numerical algorithm was developed using FORTRAN 90 to predict S-Matrix elements for alkali metal - noble gas (MNg) collisions. The...committee and the physics department for their time and effort to see me through the completion of my doctorate degree. Charlton D. Lewis, II v Table of

Self-consistent approximation beyond the CPA: Part II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaplan, T.; Gray, L.J.

1981-08-01

In Part I, Professor Leath has described the substantial efforts to generalize the CPA. In this second part, a particular self-consistent approximation for random alloys developed by Kaplan, Leath, Gray, and Diehl is described. This approximation is applicable to diagonal, off-diagonal and environmental disorder, includes cluster scattering, and yields a translationally invariant and analytic (Herglotz) average Green's function. Furthermore Gray and Kaplan have shown that an approximation for alloys with short-range order can be constructed from this theory.

RF transient analysis and stabilization of the phase and energy of the proposed PIP-II LINAC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edelen, J. P.; Chase, B. E.

This paper describes a recent effort to develop and benchmark a simulation tool for the analysis of RF transients and their compensation in an H- linear accelerator. Existing tools in this area either focus on electron LINACs or lack fundamental details about the LLRF system that are necessary to provide realistic performance estimates. In our paper we begin with a discussion of our computational models followed by benchmarking with existing beam-dynamics codes and measured data. We then analyze the effect of RF transients and their compensation in the PIP-II LINAC, followed by an analysis of calibration errors and how amore » Newton’s Method based feedback scheme can be used to regulate the beam energy to within the specified limits.« less

REDUCTION OF NITROSOBENZENES AND N-HYDROXYLANILINES BY FE (II) SPECIES: ELUCIDATION OF REACTION MECHANISM

EPA Science Inventory

There has been a substantial effort toward understanding the reduction of nitroaromatics in Fe(II)-treated ferric oxide systems, little has been done to gain insight into the factors controlling the transformation of their reaction intermediates, nitrosobenzenes and N-hydroxylani...

A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases.

PubMed

Pöhler, Robert; Krahn, Jan H; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T; Kaiser, Markus; Meyer, Hemmo

2018-02-05

AAA ATPases have pivotal functions in diverse cellular processes essential for survival and proliferation. Revealing strategies for chemical inhibition of this class of enzymes is therefore of great interest for the development of novel chemotherapies or chemical tools. Here, we characterize the compound MSC1094308 as a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B. Subsequent proteomic, genetic and biochemical studies indicate that MSC1094308 binds to a previously characterized drugable hotspot of p97, thereby inhibiting the D2 ATPase activity. Our results furthermore indicate that a similar allosteric site exists in VPS4B, suggesting conserved allosteric circuits and drugable sites in both type I and II AAA ATPases. Our results may thus guide future chemical tool and drug discovery efforts for the biomedically relevant AAA ATPases. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Human Data Supporting Glyburide in Ischemic Stroke.

PubMed

Sheth, Kevin N; Simard, J Marc; Elm, Jordan; Kronenberg, Golo; Kunte, Hagen; Kimberly, W Taylor

2016-01-01

The SUR1-TRPM4 channel is a critical determinant of edema and hemorrhagic transformation after focal ischemia. Blockade of this channel by the small molecule glyburide results in improved survival and neurological outcome in multiple preclinical models of ischemic stroke. A robust, compelling body of evidence suggests that an intravenous formulation of glyburide, RP-1127, can prevent swelling and improve outcome in patients with stroke. Retrospective studies of diabetic stroke patients show improved outcomes in patients who are continued on sulfonylureas after stroke onset. An early phase II study using magnetic resonance imaging and plasma biomarkers supports the conclusion that RP-1127 may decrease swelling and hemorrhagic transformation. Finally, the ongoing phase II RP-1127 development program has demonstrated continued safety as well as feasibility of enrollment and tolerability of the intervention. Continued efforts to complete the ongoing phase II study and definitive efficacy studies are needed to bring a candidate pharmacotherapy to a population of severe stroke patients that currently have no alternative.

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner

PubMed Central

Dalecki, Alex G.; Haeili, Mehri; Shah, Santosh; Speer, Alexander; Niederweis, Michael; Kutsch, Olaf

2015-01-01

Tuberculosis is a severe disease affecting millions worldwide. Unfortunately, treatment strategies are hampered both by the prohibitively long treatment regimen and the rise of drug-resistant strains. Significant effort has been expended in the search for new treatments, but few options have successfully emerged, and new treatment modalities are desperately needed. Recently, there has been growing interest in the synergistic antibacterial effects of copper ions (CuII/I) in combination with certain small molecular compounds, and we have previously reported development of a drug screening strategy to harness the intrinsic bactericidal properties of CuII/I. Here, we describe the copper-dependent antimycobacterial properties of disulfiram, an FDA-approved and well-tolerated sobriety aid. Disulfiram was inhibitory to mycobacteria only in the presence of CuII/I and exerted its bactericidal activity well below the active concentration of CuII/I or disulfiram alone. No other physiologically relevant bivalent transition metals (e.g., FeII, NiII, MnII, and CoII) exhibited this effect. We demonstrate that the movement of the disulfiram-copper complex across the cell envelope is porin independent and can inhibit intracellular protein functions. Additionally, the complex is able to synergistically induce intracellular copper stress responses significantly more than CuII/I alone. Our data suggest that by complexing with disulfiram, CuII/I is likely allowed unfettered access to vulnerable intracellular components, bypassing the normally sufficient copper homeostatic machinery. Overall, the synergistic antibacterial activity of CuII/I and disulfiram reveals the susceptibility of the copper homeostasis system of Mycobacterium tuberculosis to chemical attacks and establishes compounds that act in concert with copper as a new class of bacterial inhibitors. PMID:26033731

EVALUATION AND SENSITIVITY ANALYSES RESULTS OF THE MESOPUFF II MODEL WITH CAPTEX MEASUREMENTS

EPA Science Inventory

The MESOPUFF II regional Lagrangian puff model has been evaluated and tested against measurements from the Cross-Appalachian Tracer Experiment (CAPTEX) data base in an effort to assess its abilIty to simulate the transport and dispersion of a nonreactive, nondepositing tracer plu...

Modeling Code Is Helping Cleveland Develop New Products

NASA Technical Reports Server (NTRS)

1998-01-01

Master Builders, Inc., is a 350-person company in Cleveland, Ohio, that develops and markets specialty chemicals for the construction industry. Developing new products involves creating many potential samples and running numerous tests to characterize the samples' performance. Company engineers enlisted NASA's help to replace cumbersome physical testing with computer modeling of the samples' behavior. Since the NASA Lewis Research Center's Structures Division develops mathematical models and associated computation tools to analyze the deformation and failure of composite materials, its researchers began a two-phase effort to modify Lewis' Integrated Composite Analyzer (ICAN) software for Master Builders' use. Phase I has been completed, and Master Builders is pleased with the results. The company is now working to begin implementation of Phase II.

Promoting quality: the health-care organization from a management perspective.

PubMed

Glickman, Seth W; Baggett, Kelvin A; Krubert, Christopher G; Peterson, Eric D; Schulman, Kevin A

2007-12-01

Although agreement about the need for quality improvement in health care is almost universal, the means of achieving effective improvement in overall care is not well understood. Avedis Donabedian developed the structure-process-outcome framework in which to think about quality-improvement efforts. There is now a robust evidence-base in the quality-improvement literature on process and outcomes, but structure has received considerably less attention. The health-care field would benefit from expanding the current interpretation of structure to include broader perspectives on organizational attributes as primary determinants of process change and quality improvement. We highlight and discuss the following key elements of organizational attributes from a management perspective: (i) executive management, including senior leadership and board responsibilities (ii) culture, (iii) organizational design, (iv) incentive structures and (v) information management and technology. We discuss the relevant contributions from the business and medical literature for each element, and provide this framework as a roadmap for future research in an effort to develop the optimal definition of 'structure' for transforming quality-improvement initiatives.

Institutional Infrastructure for Broader Impacts Engagement - Showcasing Effective Strategies and Approaches from a Large Research Institute

NASA Astrophysics Data System (ADS)

Gold, A. U.; Sullivan, S. B.; Smith, L. K.; Lynds, S. E.

2014-12-01

The need for robust scientific and especially climate literacy is increasing. Funding agencies mandate that scientists make their findings and data publically available. Ideally, this mandate is achieved by scientists and educators working together to translate research findings into common knowledge. The Cooperative Institute for Research in Environmental Sciences (CIRES) is the largest research institute at the University of Colorado and home institute to over 500 scientists. CIRES provides an effective organizational infrastructure to support its scientists in broadening their research impact. Education specialists provide the necessary experience, connections, logistical support, and evaluation expertise to develop and conduct impactful education and outreach efforts. Outreach efforts are tailored to the project needs and the scientists' interests. They span from deep engagement efforts with a high time commitment by the scientist thus a high dosage to short presentations by the scientists that reach many people without stimulating a deep engagement and have therefore a low dosage. We use three examples of current successful programs to showcase these different engagement levels and report on their impact: i) deep transformative and time-intensive engagement through a Research Experience for Community College students program, ii) direct engagement during a teacher professional development workshop centered around a newly developed curriculum bringing authentic climate data into secondary classrooms, iii) short-time engagement through a virtual panel discussion about the state of recent climate science topics, the recordings of which were repurposed in a Massive Open Online Course (MOOC). In this presentation, we discuss the challenges and opportunities of broader impacts work. We discuss successful strategies that we developed, stress the importance of robust impact evaluation, and summarize different avenues of funding outreach efforts.

Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

PubMed Central

Zhang, Feiran; Bhat, Shridhar; Gabelli, Sandra B.; Chen, Xiaochun; Miller, Michelle S.; Nacev, Benjamin A.; Cheng, Yim Ling; Meyers, David J.; Tenney, Karen; Shim, Joong Sup; Crews, Phillip; Amzel, L. Mario; Ma, Dawei; Liu, Jun O.

2013-01-01

Methionine aminopeptidases (MetAPs) which remove the initiator methionine from nascent peptides are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our earlier efforts identified two structural classes of human MetAP1 (HsMetAP1)-selective inhibitors (1–4). But all of them failed to inhibit cellular HsMetAP1. Using Mn(II) or Zn(II) to activate HsMetAP1, we found that 1–4 could only effectively inhibit purified HsMetAP1 in the presence of physiologically unachievable concentrations of Co(II). In an effort to seek Co(II)-independent inhibitors, a novel structural class containing a 2-(pyridin-2-yl)quinazoline core has been discovered. Many compounds in this class potently and selectively inhibited HsMetAP1 without Co(II). Subsequently, we demonstrated that 11j, an auxiliary metal-dependent inhibitor, effectively inhibited HsMetAP1 in primary cells. This is the first report that an HsMetAP1-selective inhibitor is effective against its target in cells. PMID:23634668

The Effect of Vaccination on the Evolution and Population Dynamics of Avian Paramyxovirus-1

PubMed Central

Hudson, Peter J.; Poss, Mary

2010-01-01

Newcastle Disease Virus (NDV) is a pathogenic strain of avian paramyxovirus (aPMV-1) that is among the most serious of disease threats to the poultry industry worldwide. Viral diversity is high in aPMV-1; eight genotypes are recognized based on phylogenetic reconstruction of gene sequences. Modified live vaccines have been developed to decrease the economic losses caused by this virus. Vaccines derived from avirulent genotype II strains were developed in the 1950s and are in use globally, whereas Australian strains belonging to genotype I were developed as vaccines in the 1970s and are used mainly in Asia. In this study, we evaluated the consequences of attenuated live virus vaccination on the evolution of aPMV-1 genotypes. There was phylogenetic incongruence among trees based on individual genes and complete coding region of 54 full length aPMV-1 genomes, suggesting that recombinant sequences were present in the data set. Subsequently, five recombinant genomes were identified, four of which contained sequences from either genotype I or II. The population history of vaccine-related genotype II strains was distinct from other aPMV-1 genotypes; genotype II emerged in the late 19th century and is evolving more slowly than other genotypes, which emerged in the 1960s. Despite vaccination efforts, genotype II viruses have experienced constant population growth to the present. In contrast, other contemporary genotypes showed population declines in the late 1990s. Additionally, genotype I and II viruses, which are circulating in the presence of homotypic vaccine pressure, have unique selection profiles compared to nonvaccine-related strains. Collectively, these data show that vaccination with live attenuated viruses has changed the evolution of aPMV-1 by maintaining a large effective population size of a vaccine-related genotype, allowing for coinfection and recombination of vaccine and wild type strains, and by applying unique selective pressures on viral glycoproteins. PMID:20421950

An abridged history of federal involvement in space weather forecasting

NASA Astrophysics Data System (ADS)

Caldwell, Becaja; McCarron, Eoin; Jonas, Seth

2017-10-01

Public awareness of space weather and its adverse effects on critical infrastructure systems, services, and technologies (e.g., the electric grid, telecommunications, and satellites) has grown through recent media coverage and scientific research. However, federal interest and involvement in space weather dates back to the decades between World War I and World War II when the National Bureau of Standards led efforts to observe, forecast, and provide warnings of space weather events that could interfere with high-frequency radio transmissions. The efforts to observe and predict space weather continued through the 1960s during the rise of the Cold War and into the present with U.S. government efforts to prepare the nation for space weather events. This paper provides a brief overview of the history of federal involvement in space weather forecasting from World War II, through the Apollo Program, and into the present.

Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering.

PubMed

Pieper, J S; van der Kraan, P M; Hafmans, T; Kamp, J; Buma, P; van Susante, J L C; van den Berg, W B; Veerkamp, J H; van Kuppevelt, T H

2002-08-01

The limited intrinsic repair capacity of articular cartilage has stimulated continuing efforts to develop tissue engineered analogues. Matrices composed of type II collagen and chondroitin sulfate (CS), the major constituents of hyaline cartilage, may create an appropriate environment for the generation of cartilage-like tissue. In this study, we prepared, characterized, and evaluated type 11 collagen matrices with and without CS. Type II collagen matrices were prepared using purified, pepsin-treated, type II collagen. Techniques applied to prepare type I collagen matrices were found unsuitable for type II collagen. Crosslinking of collagen and covalent attachment of CS was performed using 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide. Porous matrices were prepared by freezing and lyophilization, and their physico-chemical characteristics (degree of crosslinking, denaturing temperature, collagenase-resistance, amount of CS incorporated) established. Matrices were evaluated for their capacity to sustain chondrocyte proliferation and differentiation in vitro. After 7 d of culture, chondrocytes were mainly located at the periphery of the matrices. In contrast to type I collagen, type II collagen supported the distribution of cells throughout the matrix. After 14 d of culture, matrices were surfaced with a cartilagenous-like layer, and occasionally clusters of chondrocytes were present inside the matrix. Chondrocytes proliferated and differentiated as indicated by biochemical analyses, ultrastructural observations, and reverse transcriptase PCR for collagen types I, II and X. No major differences were observed with respect to the presence or absence of CS in the matrices.

Inclusion compounds between α-, β- and γ-cyclodextrins: iron II lactate: a theoretical and experimental study using diffusion coefficients and molecular mechanics

NASA Astrophysics Data System (ADS)

Leite, Rosiley A.; Lino, Antonio C. S.; Takahata, Yuji

2003-01-01

The inclusion compounds between iron II lactate and three different cyclodextrins (CDs) were studied by means of experimental and theoretical data. The importance of iron II in the human metabolism effort the necessity of a minimum concentration to the human life. Malnutrition is one great problem in social politics of many countries on the world. The possibility to the development of novel medicines with the iron II species stable look for an increase on the efficiency for this kind of aid. Kinetics measurements confirm the possibility to stop the oxidation reaction. It was the first indication of efficient molecular encapsulation. Diffusion coefficient measurements were carried out by Taylor-Aris diffusion technique. The decrease of diffusion coefficients measured for iron II lactate when alone and forming the inclusion complexes was obtained for all hosts molecules used. Molecular Mechanics calculations were performed to elucidate the perfect arrange of iron II lactate inside CDs cavity. No great differences were obtained to the binding energy for the different hosts. Using the software HyperChem6.03v MM+, AMBER94 and OPLS Forced Fields for iron atom in two chemical environments (a) vacuum and (b) with addition of 250 water molecules (MM+). The solvent treatment was decisive to the order of stability. This order was β-CD>γ-CD>α-CD, the same order of solubility in water. The results contained in this work confirm the possibility to protect iron II lactate against oxidation.

Migrating the Belle II collaborative services and tools

NASA Astrophysics Data System (ADS)

Braun, N.; Dossett, D.; Dramburg, M.; Frost, O.; Gellrich, A.; Grygier, J.; Hauth, T.; Jahnke-Zumbusch, D.; Knittel, D.; Kuhr, T.; Levonian, S.; Moser, H.-G.; Li, L.; Nakao, N.; Prim, M.; Reest, P. v. d.; Schwenssen, F.; Urquijo, P.; Vennemann, B.

2017-10-01

The Belle II collaboration decided in 2016 to migrate its collaborative services and tools into the existing IT infrastructure at DESY. The goal was to reduce the maintenance effort for solutions operated by Belle II members as well as to deploy state-of-art technologies. In addition, some new services and tools were or will be introduced. Planning and migration work was carried out by small teams consisting of experts form Belle II and the involved IT divisions. The migration was successfully accomplished before the KEK computer centre replacement in August 2016.

No-Impact Threshold Values for NRAP's Reduced Order Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Last, George V.; Murray, Christopher J.; Brown, Christopher F.

2013-02-01

The purpose of this study was to develop methodologies for establishing baseline datasets and statistical protocols for determining statistically significant changes between background concentrations and predicted concentrations that would be used to represent a contamination plume in the Gen II models being developed by NRAP’s Groundwater Protection team. The initial effort examined selected portions of two aquifer systems; the urban shallow-unconfined aquifer system of the Edwards-Trinity Aquifer System (being used to develop the ROM for carbon-rock aquifers, and the a portion of the High Plains Aquifer (an unconsolidated and semi-consolidated sand and gravel aquifer, being used to development the ROMmore » for sandstone aquifers). Threshold values were determined for Cd, Pb, As, pH, and TDS that could be used to identify contamination due to predicted impacts from carbon sequestration storage reservoirs, based on recommendations found in the EPA’s ''Unified Guidance for Statistical Analysis of Groundwater Monitoring Data at RCRA Facilities'' (US Environmental Protection Agency 2009). Results from this effort can be used to inform a ''no change'' scenario with respect to groundwater impacts, rather than the use of an MCL that could be significantly higher than existing concentrations in the aquifer.« less

Synthesis, Characterization, and Handling of Eu(II)-Containing Complexes for Molecular Imaging Applications

NASA Astrophysics Data System (ADS)

Basal, Lina A.; Allen, Matthew J.

2018-03-01

Considerable research effort has focused on the in vivo use of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is Eu(II)-containing complexes because the Eu(II/III) redox couple enables imaging with multiple modalities including magnetic resonance and photoacoustic imaging. The use of Eu(II) requires care in handling to avoid unintended oxidation during synthesis and characterization. This review describes recent advances in the field of imaging agents based on discrete Eu(II)-containing complexes with specific focus on the synthesis, characterization, and handling of aqueous Eu(II)-containing complexes.

Incorporating phosphorus cycling into global modeling efforts: a worthwhile, tractable endeavor.

PubMed

Reed, Sasha C; Yang, Xiaojuan; Thornton, Peter E

2015-10-01

324 I. 324 II. 325 III. 326 IV. 327 328 References 328 SUMMARY: Myriad field, laboratory, and modeling studies show that nutrient availability plays a fundamental role in regulating CO2 exchange between the Earth's biosphere and atmosphere, and in determining how carbon pools and fluxes respond to climatic change. Accordingly, global models that incorporate coupled climate-carbon cycle feedbacks made a significant advance with the introduction of a prognostic nitrogen cycle. Here we propose that incorporating phosphorus cycling represents an important next step in coupled climate-carbon cycling model development, particularly for lowland tropical forests where phosphorus availability is often presumed to limit primary production. We highlight challenges to including phosphorus in modeling efforts and provide suggestions for how to move forward. No claim to original US government works New Phytologist © 2015 New Phytologist Trust.

An Overview of Materials Structures for Extreme Environments Efforts for 2015 SBIR Phases I and II

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2017-01-01

Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for Agency projects. This report highlights innovative SBIR 2015 Phase I and II projects that specifically address areas in Materials and Structures for Extreme Environments, one of six core competencies at NASA Glenn Research Center. Each article describes an innovation, defines its technical objective, and highlights NASA applications as well as commercial and industrial applications. Ten technologies are featured: metamaterials-inspired aerospace structures, metallic joining to advanced ceramic composites, multifunctional polyolefin matrix composite structures, integrated reacting fluid dynamics and predictive materials degradation models for propulsion system conditions, lightweight inflatable structural airlock (LISA), copolymer materials for fused deposition modeling 3-D printing of nonstandard plastics, Type II strained layer superlattice materials development for space-based focal plane array applications, hydrogenous polymer-regolith composites for radiation-shielding materials, a ceramic matrix composite environmental barrier coating durability model, and advanced composite truss printing for large solar array structures. This report serves as an opportunity for NASA engineers, researchers, program managers, and other personnel to learn about innovations in this technology area as well as possibilities for collaboration with innovative small businesses that could benefit NASA programs and projects.

Computer Program (HEVSIM) for Heavy Duty Vehicle Fuel Economy and Performance Simulation. Volume II: Users' Manual.

DOT National Transportation Integrated Search

1981-09-01

Volume II is the second volume of a three volume document describing the computer program HEVSIM for use with buses and heavy duty trucks. This volume is a user's manual describing how to prepare data input and execute the program. A strong effort ha...

The World War II Era and Human Rights Education

ERIC Educational Resources Information Center

Waters, Stewart; Russell, William B., III

2012-01-01

International revulsion at the violation of human rights during World War II helped spark a global movement to define and protect individual human rights. Starting with the creation of war crimes tribunals after the war, this newfound awareness stimulated a concerted international effort to establish human rights for all, both in periods of war…

Model Transformation for a System of Systems Dependability Safety Case

NASA Technical Reports Server (NTRS)

Murphy, Judy; Driskell, Steve

2011-01-01

The presentation reviews the dependability and safety effort of NASA's Independent Verification and Validation Facility. Topics include: safety engineering process, applications to non-space environment, Phase I overview, process creation, sample SRM artifact, Phase I end result, Phase II model transformation, fault management, and applying Phase II to individual projects.

China's Propaganda in the United States during World War II.

ERIC Educational Resources Information Center

Tsang, Kuo-jen

Drawing data from a variety of sources, a study was undertaken to place China's propaganda activities in the United States during World War II into a historical perspective. Results showed that China's propaganda efforts consisted of official and unofficial activities and activities directed toward overseas Chinese. The official activities were…

Advanced Stirling Convertor Update

NASA Astrophysics Data System (ADS)

Wood, J. Gary; Carroll, Cliff; Matejczyk, Dan; Penswick, L. B.; Soendker, E.

2006-01-01

This paper reports on the 88 We Advanced Stirling Convertor (ASC) currently being developed under Phase II of a NASA NRA program for possible use in advanced high specific power radioisotope space power systems. An early developmental unit, the Frequency Test Bed (FTB) which was built and tested in Phase I demonstrated 36% efficiency. The ASC-1 currently being developed under Phase II, uses a high temperature heater head to allow for operation at 850 °C and is expected to have an efficiency approaching 40% (based on AC electrical out) at a temperature ratio of 3.1. The final lightweight ASC-2 convertor to be developed in Phase III is expected to have a mass of approximately 1 kg. The implementation of the ASC would allow for much higher specific power radioisotope power systems, requiring significantly less radioisotope fuel than current systems. The first run of the ASC-1 occurred in September 2005, and full temperature operation was achieved in early October 2005. Presented is an update on progress on the ASC program as well as the plans for future development. Also presented are efforts being performed to ensure the ASC has the required long life already demonstrated in free-piston Stirling cryocoolers.

Assessing Hospital Disaster Readiness Over Time at the US Department of Veterans Affairs.

PubMed

Der-Martirosian, Claudia; Radcliff, Tiffany A; Gable, Alicia R; Riopelle, Deborah; Hagigi, Farhad A; Brewster, Pete; Dobalian, Aram

2017-02-01

Introduction There have been numerous initiatives by government and private organizations to help hospitals become better prepared for major disasters and public health emergencies. This study reports on efforts by the US Department of Veterans Affairs (VA), Veterans Health Administration, Office of Emergency Management's (OEM) Comprehensive Emergency Management Program (CEMP) to assess the readiness of VA Medical Centers (VAMCs) across the nation. Hypothesis/Problem This study conducts descriptive analyses of preparedness assessments of VAMCs and examines change in hospital readiness over time. To assess change, quantitative analyses of data from two phases of preparedness assessments (Phase I: 2008-2010; Phase II: 2011-2013) at 137 VAMCs were conducted using 61 unique capabilities assessed during the two phases. The initial five-point Likert-like scale used to rate each capability was collapsed into a dichotomous variable: "not-developed=0" versus "developed=1." To describe changes in preparedness over time, four new categories were created from the Phase I and Phase II dichotomous variables: (1) rated developed in both phases; (2) rated not-developed in Phase I but rated developed in Phase II; (3) rated not-developed in both phases; and (4) rated developed in Phase I but rated not- developed in Phase II. From a total of 61 unique emergency preparedness capabilities, 33 items achieved the desired outcome - they were rated either "developed in both phases" or "became developed" in Phase II for at least 80% of VAMCs. For 14 items, 70%-80% of VAMCs achieved the desired outcome. The remaining 14 items were identified as "low-performing" capabilities, defined as less than 70% of VAMCs achieved the desired outcome. Measuring emergency management capabilities is a necessary first step to improving those capabilities. Furthermore, assessing hospital readiness over time and creating robust hospital readiness assessment tools can help hospitals make informed decisions regarding allocation of resources to ensure patient safety, provide timely access to high-quality patient care, and identify best practices in emergency management during and after disasters. Moreover, with some minor modifications, this comprehensive, all-hazards-based, hospital preparedness assessment tool could be adapted for use beyond the VA. Der-Martirosian C , Radcliff TA , Gable AR , Riopelle D , Hagigi FA , Brewster P , Dobalian A . Assessing hospital disaster readiness over time at the US Department of Veterans Affairs. Prehsop Disaster Med. 2017;32(1):46-57.

Female genital mutilation and efforts to achieve Millennium Development Goals 3, 4, and 5 in southeast Nigeria.

PubMed

Lawani, Lucky O; Onyebuchi, Azubuike K; Iyoke, Chukwuemeka A; Okeke, Nwabunike E

2014-05-01

To determine the prevalence of female genital mutilation (FGM), the common forms of FGM, reasons for the practice, associated obstetric outcomes, and how these have affected efforts to achieve Millennium Development Goals (MDGs) 3, 4, and 5 in southeast Nigeria. A prospective descriptive study of parturients in southeast Nigeria was conducted from January to December 2012. All primigravid women attending delivery services at 2 health institutions during the study period were recruited, examined, and classified using the 2008 WHO classification for FGM. The mean age of the 516 participants was 27.24±4.80 years and most (66.3%) had undergone FGM. Type II FGM was the most common form, accounting for 59.6% of cases. Most FGM procedures were performed in infancy (97.1%) and for cultural reasons (60.8%). Women who had undergone FGM had significantly higher risk for episiotomy, perineal tear, hemorrhage, cesarean delivery, neonatal resuscitation, fresh stillbirth/early neonatal death, and longer hospitalization, with higher risk ratios associated with higher degrees of FGM. FGM is still a common practice in southeast Nigeria, where its association with adverse reproductive outcomes militates against efforts to achieve MDGs 3, 4, and 5. Copyright © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

JANE: efficient mapping of prokaryotic ESTs and variable length sequence reads on related template genomes

PubMed Central

2009-01-01

Background ESTs or variable sequence reads can be available in prokaryotic studies well before a complete genome is known. Use cases include (i) transcriptome studies or (ii) single cell sequencing of bacteria. Without suitable software their further analysis and mapping would have to await finalization of the corresponding genome. Results The tool JANE rapidly maps ESTs or variable sequence reads in prokaryotic sequencing and transcriptome efforts to related template genomes. It provides an easy-to-use graphics interface for information retrieval and a toolkit for EST or nucleotide sequence function prediction. Furthermore, we developed for rapid mapping an enhanced sequence alignment algorithm which reassembles and evaluates high scoring pairs provided from the BLAST algorithm. Rapid assembly on and replacement of the template genome by sequence reads or mapped ESTs is achieved. This is illustrated (i) by data from Staphylococci as well as from a Blattabacteria sequencing effort, (ii) mapping single cell sequencing reads is shown for poribacteria to sister phylum representative Rhodopirellula Baltica SH1. The algorithm has been implemented in a web-server accessible at http://jane.bioapps.biozentrum.uni-wuerzburg.de. Conclusion Rapid prokaryotic EST mapping or mapping of sequence reads is achieved applying JANE even without knowing the cognate genome sequence. PMID:19943962

Disposition of fuel elements from the Aberdeen and Sandia pulse reactor (SPR-II) assemblies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mckerley, Bill; Bustamante, Jacqueline M; Costa, David A

2010-01-01

We describe the disposition of fuel from the Aberdeen (APR) and the Sandia Pulse Reactors (SPR-II) which were used to provide intense neutron bursts for radiation effects testing. The enriched Uranium - 10% Molybdenum fuel from these reactors was shipped to the Los Alamos National Laboratory (LANL) for size reduction prior to shipment to the Savannah River Site (SRS) for final disposition in the H Canyon facility. The Shipper/Receiver Agreements (SRA), intra-DOE interfaces, criticality safety evaluations, safety and quality requirements and key materials management issues required for the successful completion of this project will be presented. This work is inmore » support of the DOE Consolidation and Disposition program. Sandia National Laboratories (SNL) has operated pulse nuclear reactor research facilities for the Department of Energy since 1961. The Sandia Pulse Reactor (SPR-II) was a bare metal Godiva-type reactor. The reactor facilities have been used for research and development of nuclear and non-nuclear weapon systems, advanced nuclear reactors, reactor safety, simulation sources and energy related programs. The SPR-II was a fast burst reactor, designed and constructed by SNL that became operational in 1967. The SPR-ll core was a solid-metal fuel enriched to 93% {sup 235}U. The uranium was alloyed with 10 weight percent molybdenum to ensure the phase stabilization of the fuel. The core consisted of six fuel plates divided into two assemblies of three plates each. Figure 1 shows a cutaway diagram of the SPR-II Reactor with its decoupling shroud. NNSA charged Sandia with removing its category 1 and 2 special nuclear material by the end of 2008. The main impetus for this activity was based on NNSA Administrator Tom D'Agostino's six focus areas to reenergize NNSA's nuclear material consolidation and disposition efforts. For example, the removal of SPR-II from SNL to DAF was part of this undertaking. This project was in support of NNSA's efforts to consolidate the locations of special nuclear material (SNM) to reduce the cost of securing many SNM facilities. The removal of SPR-II from SNL was a significant accomplishment in SNL's de-inventory efforts and played a key role in reducing the number of locations requiring the expensive security measures required for category 1 and 2 SNM facilities. A similar pulse reactor was fabricated at the Y-12 National Security Complex beginning in the late 1960's. This Aberdeen Pulse Reactor (APR) was operated at the Army Pulse Radiation Facility (APRF) located at the Aberdeen Test Center (ATC) in Maryland. When the APRF was shut down in 2003, a portion of the DOE-owned Special Nuclear Material (SNM) was shipped to an interim facility for storage. Subsequently, the DOE determined that the material from both the SPR-II and the APR would be processed in the H-Canyon at the Savannah River Site (SRS). Because of the SRS receipt requirements some of the material was sent to the Los Alamos National Laboratory (LANL) for size-reduction prior to shipment to the SRS for final disposition.« less

List of U.S. Army Research Institute Research and Technical Publications for Public Release/Unlimited Distribution. Fiscal Year 2007 (October 1, 2006 to September 30, 2007) With Author Index and Report Titles and Subject Terms Index

DTIC Science & Technology

2008-04-01

Sciences (ARI) SBIR request, the Army Interpersonal Skills Assessment ( AISA ) battery consists of five measures designed to evaluate the interpersonal...placed in positions that require increasing interaction effectiveness. The goal of the AISA is to gauge the Soldier’s aptitude to effectively manage...Phase II of this SBIR effort, the AISA battery underwent a full development cycle including focus group reviews by senior Non-Commissioned Officers

Integrated Data Visualization and Virtual Reality Tool

NASA Technical Reports Server (NTRS)

Dryer, David A.

1998-01-01

The Integrated Data Visualization and Virtual Reality Tool (IDVVRT) Phase II effort was for the design and development of an innovative Data Visualization Environment Tool (DVET) for NASA engineers and scientists, enabling them to visualize complex multidimensional and multivariate data in a virtual environment. The objectives of the project were to: (1) demonstrate the transfer and manipulation of standard engineering data in a virtual world; (2) demonstrate the effects of design and changes using finite element analysis tools; and (3) determine the training and engineering design and analysis effectiveness of the visualization system.

Objective Lightning Probability Forecasting for Kennedy Space Center and Cape Canaveral Air Force Station, Phase III

NASA Technical Reports Server (NTRS)

Crawford, Winifred C.

2010-01-01

The AMU created new logistic regression equations in an effort to increase the skill of the Objective Lightning Forecast Tool developed in Phase II (Lambert 2007). One equation was created for each of five sub-seasons based on the daily lightning climatology instead of by month as was done in Phase II. The assumption was that these equations would capture the physical attributes that contribute to thunderstorm formation more so than monthly equations. However, the SS values in Section 5.3.2 showed that the Phase III equations had worse skill than the Phase II equations and, therefore, will not be transitioned into operations. The current Objective Lightning Forecast Tool developed in Phase II will continue to be used operationally in MIDDS. Three warm seasons were added to the Phase II dataset to increase the POR from 17 to 20 years (1989-2008), and data for October were included since the daily climatology showed lightning occurrence extending into that month. None of the three methods tested to determine the start of the subseason in each individual year were able to discern the start dates with consistent accuracy. Therefore, the start dates were determined by the daily climatology shown in Figure 10 and were the same in every year. The procedures used to create the predictors and develop the equations were identical to those in Phase II. The equations were made up of one to three predictors. TI and the flow regime probabilities were the top predictors followed by 1-day persistence, then VT and Ll. Each equation outperformed four other forecast methods by 7-57% using the verification dataset, but the new equations were outperformed by the Phase II equations in every sub-season. The reason for the degradation may be due to the fact that the same sub-season start dates were used in every year. It is likely there was overlap of sub-season days at the beginning and end of each defined sub-season in each individual year, which could very well affect equation performance.

The role of ligand covalency in the selective activation of metalloenediynes for Bergman cyclization

PubMed Central

Porter, Meghan R.; Zaleski, Jeffrey M.

2017-01-01

One of the key concerns with the development of radical-generating reactive therapeutics is the ability to control the activation event within a biological environment. To that end, a series of quinoline-metal-loenediynes of the form M(QuiED)·2Cl (M = Cu(II), Fe(II), Mg(II), or Zn(II)) and their independently synthesized cyclized analogs have been prepared in an effort to elucidate Bergman cyclization (BC) reactivity differences in solution. HRMS(ESI) establishes a solution stoichiometry of 1:1 metal to ligand with coordination of one chloride counter ion to the metal center. EPR spectroscopy of Cu(QuiED)·2Cl and Cu (QuiBD)·2Cl denotes an axially-elongated tetragonal octahedron (g║ > g⊥ > 2.0023) with a dx2–y2 ground state, while the electronic absorption spectrum reveals a pπ Cl→Cu(II) LMCT feature at 19,000 cm −1, indicating a solution structure with three nitrogens and a chloride in the equatorial plane with the remaining quinoline nitrogen and solvent in the axial positions. Investigations into the BC activity reveal formation of the cyclized product from the Cu(II) and Fe(II) complexes after 12 h at 45 °C in solution, while no product is observed for the Mg(II) or Zn(II) complexes under identical conditions. The basis of this reactivity difference has been found to be a steric effect leading to metal–ligand bond elongation and thus, a retardation of solution reactivity. These results demonstrate how careful consideration of ligand and complex structure may allow for a degree of control and selective activation of these reactive agents. PMID:28931964

The role of ligand covalency in the selective activation of metalloenediynes for Bergman cyclization.

PubMed

Porter, Meghan R; Zaleski, Jeffrey M

2016-01-08

One of the key concerns with the development of radical-generating reactive therapeutics is the ability to control the activation event within a biological environment. To that end, a series of quinoline-metal-loenediynes of the form M( QuiED )·2Cl (M = Cu(II), Fe(II), Mg(II), or Zn(II)) and their independently synthesized cyclized analogs have been prepared in an effort to elucidate Bergman cyclization (BC) reactivity differences in solution. HRMS(ESI) establishes a solution stoichiometry of 1:1 metal to ligand with coordination of one chloride counter ion to the metal center. EPR spectroscopy of Cu( QuiED )·2Cl and Cu ( QuiBD )·2Cl denotes an axially-elongated tetragonal octahedron ( g ║ > g ⊥ > 2.0023) with a d x 2 - y 2 ground state, while the electronic absorption spectrum reveals a pπ Cl→Cu(II) LMCT feature at 19,000 cm -1 , indicating a solution structure with three nitrogens and a chloride in the equatorial plane with the remaining quinoline nitrogen and solvent in the axial positions. Investigations into the BC activity reveal formation of the cyclized product from the Cu(II) and Fe(II) complexes after 12 h at 45 °C in solution, while no product is observed for the Mg(II) or Zn(II) complexes under identical conditions. The basis of this reactivity difference has been found to be a steric effect leading to metal-ligand bond elongation and thus, a retardation of solution reactivity. These results demonstrate how careful consideration of ligand and complex structure may allow for a degree of control and selective activation of these reactive agents.

Cell module and fuel conditioner development

NASA Technical Reports Server (NTRS)

Feret, J. M.

1982-01-01

The efforts performed to develop a phosphoric acid fuel cell (PAFC) stack design having a 10 kW power rating for operation at higher than atmospheric pressure based on the existing Mark II design configuration are described. The work involves: (1) Performance of pertinent functional analysis, trade studies and thermodynamic cycle analysis for requirements definition and system operating parameter selection purposes, (2) characterization of fuel cell materials and components, and performance testing and evaluation of the repeating electrode components, (3) establishment of the state-of-the-art manufacturing technology for all fuel cell components at Westinghouse and the fabrication of short stacks of various sites, and (4) development of a 10 kW PAFC stack design for higher pressure operation utilizing the top down systems engineering approach.

An Overview of the Cooperative Effort between the United States Department of Energy and the China Atomic Energy Authority to Enhance MPC&A Inspections for Civil Nuclear Facilities in China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahern, Keith; Daming, Liu; Hanley, Tim

The United States Department of Energy, National Nuclear Security Administration (DOE/NNSA) and the China Atomic Energy Authority (CAEA) are cooperating to enhance the domestic regulatory inspections capacity for special nuclear material protection, control and accounting (MPC&A) requirements for civil nuclear facilities in China. This cooperation is conducted under the auspices of the Agreement between the Department of Energy of the United States of America and the State Development and Planning Commission of the People s Republic of China on Cooperation Concerning Peaceful Uses of Nuclear Technology. This initial successful effort was conducted in three phases. Phase I focused on introducingmore » CAEA personnel to DOE and U. S. Nuclear Regulatory Commission inspection methods for U. S. facilities. This phase was completed in January 2008 during meetings in Beijing. Phase II focused on developing physical protection and material control and accounting inspection exercises that enforced U. S. inspection methods identified during Phase 1. Hands on inspection activities were conducted in the United States over a two week period in July 2009. Simulated deficiencies were integrated into the inspection exercises. The U. S. and Chinese participants actively identified and discussed deficiencies noted during the two week training course. The material control and accounting inspection exercises were conducted at the Paducah Gaseous Diffusion Plant (PGDP) in Paducah, KY. The physical protection inspection exercises were conducted at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, TN. Phase III leveraged information provided under Phase I and experience gained under Phase II to develop a formal inspection guide that incorporates a systematic approach to training for Chinese MPC&A field inspectors. Additional hands on exercises that are applicable to Chinese regulations were incorporated into the Phase III training material. Phase III was completed in May 2010 at the China Institute of Atomic Energy (CIAE) in Beijing. This paper provides details of the successful cooperation between DOE/NNSA and CAEA for all phases of the cooperative effort to enhance civil domestic MPC&A inspections in China.« less

In search of meta-knowledge

NASA Technical Reports Server (NTRS)

Lopez, Antonio M., Jr.

1993-01-01

Development of an Intelligent Information System (IIS) involves application of numerous artificial intelligence (AI) paradigms and advanced technologies. The National Aeronautics and Space Administration (NASA) is interested in an IIS that can automatically collect, classify, store and retrieve data, as well as develop, manipulate and restructure knowledge regarding the data and its application (Campbell et al., 1987, p.3). This interest stems in part from a NASA initiative in support of the interagency Global Change Research program. NASA's space data problems are so large and varied that scientific researchers will find it almost impossible to access the most suitable information from a software system if meta-information (metadata and meta-knowledge) is not embedded in that system. Even if more, faster, larger hardware is used, new innovative software systems will be required to organize, link, maintain, and properly archive the Earth Observing System (EOS) data that is to be stored and distributed by the EOS Data and Information System (EOSDIS) (Dozier, 1990). Although efforts are being made to specify the metadata that will be used in EOSDIS, meta-knowledge specification issues are not clear. With the expectation that EOSDIS might evolve into an IIS, this paper presents certain ideas on the concept of meta-knowledge and demonstrates how meta-knowledge might be represented in a pixel classification problem.

[Effort-Reward Imbalance in Household and Family Work--Analysing the Psychometric Properties among Fathers of Underage Children].

PubMed

Sperlich, Stefanie; Barre, Felix; Otto, Friederike

2016-02-01

Recently, the concept of effort-reward imbalance (ERI) developed by Siegrist had been applied to unpaid household and family work (ERI-HF). Evidence suggests that the imbalance between effort spent and reward received in family and domestic labor is associated with poor mental and physical health. However, so far, the adopted questionnaire ERI-HF was exclusively used among women in childcare responsibility. This paper reports on the application of the model to men in childcare responsibility using data from a clinical sample of fathers in rehabilitation clinics (N=415). Analogous to the original version, ERI-HF is divided into 2 components: (i) dysbalance of effort and reward, and (ii) overcommitment. For both components, confirmatory factor analyses revealed good to satisfactory properties. Overall, 13.4% of men in childcare responsibility showed a dysbalance between high effort and low reward of household and family work. High levels of effort were more frequently reported than high levels of low reward. With percentages ranging between 24.3 and 59.6%, a significant proportion of fathers reported difficulties to withdraw from household and family work obligations. Analyses of construct validity revealed significant associations between ERI and socio-demographic factors (number of children, employment status, single fatherhood, work-family-conflict) as well as subjective health. Taken together, our findings suggest that the instrument is applicable to men in childcare responsibility. © Georg Thieme Verlag KG Stuttgart · New York.

The Black Professor Abroad: Long-Term Teaching Experiences in Foreign Lands

ERIC Educational Resources Information Center

Fikes, Robert, Jr.

2006-01-01

The experiences of African American professors reach back nearly 150 years beginning with their pioneering efforts to educate Africans in Liberia. With the gradual racial integration of the American professoriate in the post-World War II era and the redoubled effort of the federal government and private agencies, along with the support of colleges…

The Federal Civil Rights Enforcement Effort--1974. Volume II: To Provide ... For Fair Housing.

ERIC Educational Resources Information Center

Buckley, Grace M.; And Others

This report evaluates the Civil Rights activities of seven federal agencies with fair housing responsibilities. It is the second of a series of six reports to be issued by the Commission on Civil Rights describing the structure, mechanisms, and procedures utilized by the federal departments and agencies in their effort to end discrimination…

Expanding the Conversation about SEM: Advancing SEM Efforts to Improve Student Learning and Persistence--Part II

ERIC Educational Resources Information Center

Yale, Amanda

2010-01-01

The first article in this two-part series focused on the need for enrollment management conceptual and organizational models to focus more intentionally and purposefully on efforts related to improving student learning, success, and persistence. Time and again, SEM is viewed from a conventional lens comprising marketing, recruitment and …

Supplement for Teaching Distributive Education II: Course of Study.

ERIC Educational Resources Information Center

Oklahoma State Univ., Stillwater.

This supplement is designed to provide motivational ideas for teaching the competencies in the curriculum guide, D.E. II--Course of Study (see note). Effort is made to provide ideas for teaching specific objectives for which there was not already a method recommended. Many of the suggested activities are ready to duplicate, trace, or implement…

MRP (materiel requirements planning) II: successful implementation the hard way.

PubMed

Grubbs, S C

1994-05-01

Many manufacturing companies embark on MRP II implementation projects as a method for improvement. In spite of an increasing body of knowledge regarding successful implementations, companies continue to attempt new approaches. This article reviews an actual implementation, featuring some of the mistakes made and the efforts required to still achieve "Class A" performance levels.

Oral carcinogenesis is not achieved in different carcinogen-treated PAI-1 transgenic and wild-type mouse models.

PubMed

Avgoustidis, Dimitris; Nisyrios, Themistoklis; Nkenke, Emeka; Lijnen, Roger; Ragos, Vassilis; Perrea, Despina; Donta, Ismini; Vaena, Apostolia; Yapijakis, Christos; Vairaktaris, Eleftherios

2012-01-01

In an effort to assess the role of plasminogen activator inhibitor-1 (PAI-1) in oral squamous cancer development and progression, two different carcinogen treatment protocols were conducted. Protocol I included mice from a PAI-1 transgenic (Tg) breed (n=56) and their wild-type (WT) counterparts (n=56), divided into one control group and two main experimental groups, treated with 7,12-dimethylbenz[a]anthracene (DMBA) for 8 and 16 weeks, respectively. Protocol II included the same number and types of animals and groups, which were similarly treated with 4-Nitroquinoline 1-oxide (4-NQO) in drinking water. Two drugs that affect plasma PAI-1 levels, enalapril and pravastatin, were administered to certain subgroups of animals in both protocols. None of the animals developed macroscopically-visible oral cancer lesions. Eleven animals under Protocol I and 52 animals under Protocol II died. Skin lesions were noted only in DMBA-treated animals (n=9). Almost all animals administered with 4-NQO developed alopecia and lost weight, while two of them developed stomach tumours, and one female mouse developed a large ovarian cyst. Transgenic mice may respond differently when used in well-established carcinogen models and oral carcinogenesis is hard to achieve in these rodents.

Micro-PROUST.

DTIC Science & Technology

1985-06-01

Noah needs to keep track of rainfall in the New Haven area in order to determine when to launch his ark . Write a...UNLSIIDFG92 N 2.. II4II 111220 11111 11J.4 MICROCOPY RESOLUTION TEST CHART S "- )ARDS 1963 A S !!? Ii~ Sii ". . . ," .’ "" o o." .* -. ° . ". * -. * " . -- I...unflagging effort and support in seeing this project through to fruition. V 7 .. ° - . . - , .-. - . - ., S .-’ S 1. ES , " , - u < . i ’ - SiCU,r7

Information adaptive system of NEEDS. [of NASA End to End Data System

NASA Technical Reports Server (NTRS)

Howle, W. M., Jr.; Kelly, W. L.

1979-01-01

The NASA End-to-End Data System (NEEDS) program was initiated by NASA to improve significantly the state of the art in acquisition, processing, and distribution of space-acquired data for the mid-1980s and beyond. The information adaptive system (IAS) is a program element under NEEDS Phase II which addresses sensor specific processing on board the spacecraft. The IAS program is a logical first step toward smart sensors, and IAS developments - particularly the system components and key technology improvements - are applicable to future smart efforts. The paper describes the design goals and functional elements of the IAS. In addition, the schedule for IAS development and demonstration is discussed.

Project DEEP STEAM

NASA Astrophysics Data System (ADS)

Aeschliman, D. P.; Clay, R. G.; Donaldson, A. B.; Eisenhawer, S. W.; Fox, R. L.; Johnson, D. R.; Mulac, A. J.

1982-01-01

The objective of Project DEEP STEAM is to develop the technology to economically produce heavy oils from deep reservoirs. The tasks included in this project are the development of thermally efficient delivery systems and downhole steam generation systems. During the period January 1-March 31, 1981, effort has continued on a low pressure combustion downhole generator (Rocketdyne), and on two high pressure designs (Foster-Miller Associates, Sandia National Laboratories). The Sandia design was prepared for deployment in the Wilmington Field at Long Beach, California. Progress continued on the Min-Stress II packer concept at L'Garde, Inc., and on the extruded metal packer at Foster-Miller. Initial bare string field data are reported on the insulated tubular test at Lloydminster, Saskatchewan, Canada.

Memo, "Incorporation of HLW Glass Shell V2.0 into the Flowsheets," to ED Lee, CCN: 184905, October 20, 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gimpel, Rodney F.; Kruger, Albert A.

2013-12-18

Efforts are being made to increase the efficiency and decrease the cost of vitrifying radioactive waste stored in tanks at the U.S. Department of Energy Hanford Site. The compositions of acceptable and processable high-level waste (HL W) glasses need to be optimized to minimize the waste-form volume and, hence, to reduce cost. A database of glass properties of waste glass and associated simulated waste glasses was collected and documented in PNNL 18501, Glass Property Data and Models for Estimating High-Level Waste Glass Volume and glass property models were curve-fitted to the glass compositions. A routine was developed that estimates HLmore » W glass volumes using the following glass property models: II Nepheline, II One-Percent Crystal Temperature (T1%), II Viscosity (11) II Product Consistency Tests (PCT) for boron, sodium, and lithium, and II Liquidus Temperature (TL). The routine, commonly called the HL W Glass Shell, is presented in this document. In addition to the use of the glass property models, glass composition constraints and rules, as recommend in PNNL 18501 and in other documents (as referenced in this report) were incorporated. This new version of the HL W Glass Shell should generally estimate higher waste loading in the HL W glass than previous versions.« less

Approach to developing reliable space reactor power systems

NASA Technical Reports Server (NTRS)

Mondt, Jack F.; Shinbrot, Charles H.

1991-01-01

During Phase II, the Engineering Development Phase, the SP-100 Project has defined and is pursuing a new approach to developing reliable power systems. The approach to developing such a system during the early technology phase is described along with some preliminary examples to help explain the approach. Developing reliable components to meet space reactor power system requirements is based on a top-down systems approach which includes a point design based on a detailed technical specification of a 100-kW power system. The SP-100 system requirements implicitly recognize the challenge of achieving a high system reliability for a ten-year lifetime, while at the same time using technologies that require very significant development efforts. A low-cost method for assessing reliability, based on an understanding of fundamental failure mechanisms and design margins for specific failure mechanisms, is being developed as part of the SP-100 Program.

Bridging the sanitation gap between disaster relief and development.

PubMed

Lai, Ka-Man; Ramirez, Claudia; Liu, Weilong; Kirilova, Darina; Vick, David; Mari, Joe; Smith, Rachel; Lam, Ho-Yin; Ostovari, Afshin; Shibakawa, Akifumi; Liu, Yang; Samant, Sidharth; Osaro, Lucky

2015-10-01

By interpreting disasters as opportunities to initiate the fulfilment of development needs, realise the vulnerability of the affected community and environment, and extend the legacy of relief funds and effort, this paper builds upon the concept linking relief, rehabilitation and development (LRRD) in the sanitation sector. It aims to use a composite of case studies to devise a framework for a semi-hypothetical scenario to identify critical components and generic processes for a LRRD action plan. The scenario is based on a latrine wetland sanitation system in a Muslim community. Several sub-frameworks are developed: (i) latrine design; (ii) assessment of human waste treatment; (iii) connective sanitation promotion strategy; and (iv) ecological systems and environmental services for sanitation and development. This scenario illustrates the complex issues involved in LRRD in sanitation work and provides technical notes and references for a legacy plan for disaster relief and development. © 2015 The Author(s). Disasters © Overseas Development Institute, 2015.

Research Activities for the DORIS Contribution to the Next International Terrestrial Reference Frame

NASA Technical Reports Server (NTRS)

Soudarin, L.; Moreaux, G.; Lemoine, F.; Willis, P.; Stepanek, P.; Otten, M.; Govind, R.; Kuzin, S.; Ferrage, P.

2012-01-01

For the preparation of ITRF2008, the IDS processed data from 1993 to 2008, including data from TOPEX/Poseidon, the SPOT satellites and Envisat in the weekly solutions. Since the development of ITRF2008, the IDS has been engaged in a number of efforts to try and improve the reference frame solutions. These efforts include (i) assessing the contribution of the new DORIS satellites, Jason-2 and Cryosat2 (2008-2011), (ii) individually analyzing the DORIS satellite contributions to geocenter and scale, and (iii) improving orbit dynamics (atmospheric loading effects, satellite surface force modeling. . . ). We report on the preliminary results from these research activities, review the status of the IDS combination which is now routinely generated from the contributions of the IDS analysis centers, and discuss the prospects for continued improvement in the DORIS contribution to the next international reference frame.

An all-solid-state CO2 laser driver

NASA Astrophysics Data System (ADS)

Birx, Daniel

1991-03-01

New, all-solid-state pulse generators are described which meet military requirements for an efficient, reliable pulsed power source to drive a space based CO2 laser. These SCR-commutated, nonlinear magnetic pulse compressors are fully-compatible with the present Spectra Technologies laser head design planned for use on LOWKATER. By employing SCRs rather than thyratron commutators, these pulsers should provide a significant increase in reliability over the current generation of pulsed power drivers. The first pulser which was designed and constructed was denoted COLD-I. COLD-I was designed to meet the original LOWKATER specifications and delivered at 150 joule, 20 kV pulse into a laser load at 10 to 20 Hz repetition rate. The second pulser, denoted COLD-II, was designed to provide a 45 joule, 500 nsec duration pulse at a voltage of 20 kV and a repetition rate of 1 kHz peak and 50 to 100 Hz average. The electrical efficiency was measured to be 80 percent with an input drive of 500 VDC. This pulse served as a design verification testbed for a third pulser, presently designed but not constructed and denoted COLD-III. COLD-III would be capable of producing 36 joules at the same pulse length and repetition rate at voltages of 20 kV. The Phase-II effort was a high risk, high payoff effort aimed at developing a light weight, high reliability RF power source for advanced RF CO2 laser heads under development. COLD-IV a Branched Magnetic RF Nonlinear Magnetic Pulse Compressor was built as a bread

Development of Yield and Tensile Strength Design Curves for Alloy 617

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nancy Lybeck; T. -L. Sham

2013-10-01

The U.S. Department of Energy Very High Temperature Reactor Program is acquiring data in preparation for developing an Alloy 617 Code Case for inclusion in the nuclear section of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel (B&PV) Code. A draft code case was previously developed, but effort was suspended before acceptance by ASME. As part of the draft code case effort, a database was compiled of yield and tensile strength data from tests performed in air. Yield strength and tensile strength at temperature are used to set time independent allowable stress for construction materials in B&PVmore » Code, Section III, Subsection NH. The yield and tensile strength data used for the draft code case has been augmented with additional data generated by Idaho National Laboratory and Oak Ridge National Laboratory in the U.S. and CEA in France. The standard ASME Section II procedure for generating yield and tensile strength at temperature is presented, along with alternate methods that accommodate the change in temperature trends seen at high temperatures, resulting in a more consistent design margin over the temperature range of interest.« less

You Can Help Your Country: English Children's Work during the Second World War

ERIC Educational Resources Information Center

Mayall, Berry; Morrow, Virginia

2011-01-01

Using a rich collection of archives, school histories, photographs and memoirs, this book charts and discusses the contributions English children made to the war effort during World War II. As men and women were increasingly called up for war work, as the country needed to grow as much food as possible, and as the war effort required ever…

Security and Arms Control: The Search for a More Stable Peace. Revised.

ERIC Educational Resources Information Center

Howard, Norman, Ed.; Sussman, Colleen, Ed.

Efforts of the United States since the end of World War II to advance the arms control process are discussed. There are five major sections. The first section recounts past arms control efforts--those that have worked and those that have not--and discusses the principles underlying U.S. arms control initiatives. The second section describes the…

49 CFR 26.53 - What are the good faith efforts procedures recipients follow in situations where there are...

Code of Federal Regulations, 2011 CFR

2011-10-01

... TRANSPORTATION FINANCIAL ASSISTANCE PROGRAMS Goals, Good Faith Efforts, and Counting § 26.53 What are the good...: (i) The names and addresses of DBE firms that will participate in the contract; (ii) A description of... in the contract as provided in the prime contractor's commitment; and (vi) If the contract goal is...

The Enemy Objectives Unit in World War II: Selecting Targets for Aerial Bombardment that Support the Political Purpose of War

DTIC Science & Technology

2011-05-19

Planning Staffs .......................................................................................... 26 Operation Octopus ...University Press, 2003), 96. 28 Operation Octopus Having established credibility, the EOU assigned its analysts to branches of the US air and...synchronize efforts. The EOU members coined this effort Operation Octopus . This operation was critical for the EOU as it allowed EOU members to

A Change Management Approach to Enhance Facility Maintenance Programs

DTIC Science & Technology

2014-03-27

dependent on the particular research effort and the researcher’s experience. Large groups tend to increase the decision quality but can be difficult...consolidate SME opinions on facility maintenance criteria. The Delphi method utilizes numerous questionnaire rounds to capitalize on a group think...effort provides the discussion and conclusions, recommendations, and suggestions for follow on research . 9 II. Literature Review This

Combat science: the emergence of Operational Research in World War II.

PubMed

Rau, Erik P

2005-12-01

World War II became known as the "wizard war" because the cycles of developing countermeasures and counter-countermeasures to the weapons deployed by all sides drove rapid technological change. However, technological innovation was not the only contribution scientists made to the war effort. Through Operational Research (OR)--the scientific scrutiny of new weapons, their deployment and relative efficiency--scientists also influenced how warfare itself was conducted. This new scientific field emerged in the UK, where it helped to tighten the defense against the Luftwaffe. It quickly spread to other aspects of the military machine, improving both antisubmarine campaigns and bombing strategy. But although this analytical approach to warfare offered military commanders a factual basis on which to base difficult decisions and deal with tactical and strategic uncertainty, it was not without controversy. Indeed, several recommendations that came out of OR sparked disputes over the allocation of resources and strategic priorities.

Automating curation using a natural language processing pipeline

PubMed Central

Alex, Beatrice; Grover, Claire; Haddow, Barry; Kabadjov, Mijail; Klein, Ewan; Matthews, Michael; Tobin, Richard; Wang, Xinglong

2008-01-01

Background: The tasks in BioCreative II were designed to approximate some of the laborious work involved in curating biomedical research papers. The approach to these tasks taken by the University of Edinburgh team was to adapt and extend the existing natural language processing (NLP) system that we have developed as part of a commercial curation assistant. Although this paper concentrates on using NLP to assist with curation, the system can be equally employed to extract types of information from the literature that is immediately relevant to biologists in general. Results: Our system was among the highest performing on the interaction subtasks, and competitive performance on the gene mention task was achieved with minimal development effort. For the gene normalization task, a string matching technique that can be quickly applied to new domains was shown to perform close to average. Conclusion: The technologies being developed were shown to be readily adapted to the BioCreative II tasks. Although high performance may be obtained on individual tasks such as gene mention recognition and normalization, and document classification, tasks in which a number of components must be combined, such as detection and normalization of interacting protein pairs, are still challenging for NLP systems. PMID:18834488

A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2.

PubMed

Thiele, Ines; Hyduke, Daniel R; Steeb, Benjamin; Fankam, Guy; Allen, Douglas K; Bazzani, Susanna; Charusanti, Pep; Chen, Feng-Chi; Fleming, Ronan M T; Hsiung, Chao A; De Keersmaecker, Sigrid C J; Liao, Yu-Chieh; Marchal, Kathleen; Mo, Monica L; Özdemir, Emre; Raghunathan, Anu; Reed, Jennifer L; Shin, Sook-il; Sigurbjörnsdóttir, Sara; Steinmann, Jonas; Sudarsan, Suresh; Swainston, Neil; Thijs, Inge M; Zengler, Karsten; Palsson, Bernhard O; Adkins, Joshua N; Bumann, Dirk

2011-01-18

Metabolic reconstructions (MRs) are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner. Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem. Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base. The consensus MR was obtained starting from two independently developed MRs for S. Typhimurium. Key results of this reconstruction jamboree include i) development and implementation of a community-based workflow for MR annotation and reconciliation; ii) incorporation of thermodynamic information; and iii) use of the consensus MR to identify potential multi-target drug therapy approaches. Taken together, with the growing number of parallel MRs a structured, community-driven approach will be necessary to maximize quality while increasing adoption of MRs in experimental design and interpretation.

A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thiele, Ines; Hyduke, Daniel R.; Steeb, Benjamin

2011-01-01

Metabolic reconstructions (MRs) are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner. Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem. Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base. The consensus MR was obtained starting from two independently developed MRs for S. Typhimurium. Key results of thismore » reconstruction jamboree include i) development and implementation of a community-based workflow for MR annotation and reconciliation; ii) incorporation of thermodynamic information; and iii) use of the consensus MR to identify potential multi-target drug therapy approaches. Finally, taken together, with the growing number of parallel MRs a structured, community-driven approach will be necessary to maximize quality while increasing adoption of MRs in experimental design and interpretation.« less

Intelligent Engine Systems: Bearing System

NASA Technical Reports Server (NTRS)

Singh, Arnant P.

2008-01-01

The overall requirements necessary for sensing bearing distress and the related criteria to select a particular rotating sensor were established during the phase I. The current phase II efforts performed studies to evaluate the Robustness and Durability Enhancement of the rotating sensors, and to design, and develop the Built-in Telemetry System concepts for an aircraft engine differential sump. A generic test vehicle that can test the proposed bearing diagnostic system was designed, developed, and built. The Timken Company, who also assisted with testing the GE concept of using rotating sensors for the differential bearing diagnostics during previous phase, was selected as a subcontractor to assist General Electric (GE) for the design, and procurement of the test vehicle. A purchase order was prepared to define the different sub-tasks, and deliverables for this task. The University of Akron was selected to provide the necessary support for installing, and integrating the test vehicle with their newly designed test facility capable of simulating the operating environment for the planned testing. The planned testing with good and damaged bearings will be on hold pending further continuation of this effort during next phase.

Curriculum Redesign in Veterinary Medicine: Part II.

PubMed

Macik, Maria L; Chaney, Kristin P; Turner, Jacqueline S; Rogers, Kenita S; Scallan, Elizabeth M; Korich, Jodi A; Fowler, Debra; Keefe, Lisa M

Curricular review is considered a necessary component for growth and enhancement of academic programs and requires time, energy, creativity, and persistence from both faculty and administration. On a larger scale, a comprehensive redesign effort involves forming a dedicated faculty redesign team, developing program learning outcomes, mapping the existing curriculum, and reviewing the curriculum in light of collected stakeholder data. The faculty of the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (TAMU) recently embarked on a comprehensive curriculum redesign effort through partnership with the university's Center for Teaching Excellence. Using a previously developed evidence-based model of program redesign, TAMU created a process for use in veterinary medical education, which is described in detail in the first part of this article series. An additional component of the redesign process that is understated, yet vital for success, is faculty buy-in and support. Without faculty engagement, implementation of data-driven curricular changes stemming from program evaluation may be challenging. This second part of the article series describes the methodology for encouraging faculty engagement through the final steps of the redesign initiative and the lessons learned by TAMU through the redesign process.

Summary - National Dissemination and the Five Target States, Part 3, Final Report for Phase II--Dissemination, Rural Shared Services.

ERIC Educational Resources Information Center

Northern Montana Coll., Havre.

The dissemination phase (Phase II) of the Rural Shared Services Project is reported in this document. Efforts of the dissemination phase were concentrated in 5 target states: Vermont, Georgia, Wyoming, Montana, and New Mexico; national dissemination was limited to attendance at national conferences, the U. S. Office of Education PREP materials for…

Winning the War: A Historical Analysis of the FFA during World War II

ERIC Educational Resources Information Center

Wolf, Kattlyn J.; Connors, James J.

2009-01-01

The United States' participation in World War II affected millions of men, women, and children, both at home and around the world. The war effort also affected the Future Farmers of America (FFA). FFA members, agriculture teachers, and national FFA officers all volunteered to serve their country during the war. Local FFA chapters and individual…

Contribution of the Nurses’ Health Studies to Uncovering Risk Factors for Type 2 Diabetes: Diet, Lifestyle, Biomarkers, and Genetics

PubMed Central

Ley, Sylvia H.; Ardisson Korat, Andres V.; Sun, Qi; Tobias, Deirdre K.; Zhang, Cuilin; Qi, Lu; Willett, Walter C.; Manson, JoAnn E.

2016-01-01

Objectives. To review the contribution of the Nurses’ Health Study (NHS) and the NHS II to addressing hypotheses regarding risk factors for type 2 diabetes. Methods. We carried out a narrative review of 1976 to 2016 NHS and NHS II publications. Results. The NHS and NHS II have uncovered important roles in type 2 diabetes for individual nutrients, foods, dietary patterns, and physical activity independent of excess body weight. Up to 90% of type 2 diabetes cases are potentially preventable if individuals follow a healthy diet and lifestyle. The NHS investigations have also identified novel biomarkers for diabetes, including adipokines, inflammatory cytokines, nutrition metabolites, and environmental pollutants, offering new insights into the pathophysiology of the disease. Global collaborative efforts have uncovered many common genetic variants associated with type 2 diabetes and improved our understanding of gene–environment interactions. Continued efforts to identify epigenetic, metagenomic, and metabolomic risk factors for type 2 diabetes have the potential to reveal new pathways and improve prediction and prevention. Conclusions. Over the past several decades, the NHS and NHS II have made major contributions to public health recommendations and strategies designed to reduce the global burden of diabetes. PMID:27459454

Contribution of the Nurses' Health Studies to Uncovering Risk Factors for Type 2 Diabetes: Diet, Lifestyle, Biomarkers, and Genetics.

PubMed

Ley, Sylvia H; Ardisson Korat, Andres V; Sun, Qi; Tobias, Deirdre K; Zhang, Cuilin; Qi, Lu; Willett, Walter C; Manson, JoAnn E; Hu, Frank B

2016-09-01

To review the contribution of the Nurses' Health Study (NHS) and the NHS II to addressing hypotheses regarding risk factors for type 2 diabetes. We carried out a narrative review of 1976 to 2016 NHS and NHS II publications. The NHS and NHS II have uncovered important roles in type 2 diabetes for individual nutrients, foods, dietary patterns, and physical activity independent of excess body weight. Up to 90% of type 2 diabetes cases are potentially preventable if individuals follow a healthy diet and lifestyle. The NHS investigations have also identified novel biomarkers for diabetes, including adipokines, inflammatory cytokines, nutrition metabolites, and environmental pollutants, offering new insights into the pathophysiology of the disease. Global collaborative efforts have uncovered many common genetic variants associated with type 2 diabetes and improved our understanding of gene-environment interactions. Continued efforts to identify epigenetic, metagenomic, and metabolomic risk factors for type 2 diabetes have the potential to reveal new pathways and improve prediction and prevention. Over the past several decades, the NHS and NHS II have made major contributions to public health recommendations and strategies designed to reduce the global burden of diabetes.

Deep Bore Storage of Nuclear Waste Using MMW (Millimeter Wave) Technology, STTR Fast Track Project, Phase I Final Report-Revised

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oglesby, Kenneth D.; Woskov, Paul; Einstein, Herbert

This report covers the technical work in Phase I of this DOE-Nuclear Program STTR Fast Track project. All key tasks were successfully performed, new tasks were added to utilize DOD-AFRL’s 95 GigaHertz (GHz) gyrotron in Phase II, while other lesser tasks were left for Phase II efforts or were requested to be made optional. This research adds to our understanding of using MMW power to melt and vaporize rocks and steel/ metals and laid plans for future testing in Phase II. This work built upon a prior DOE project DE-EE0005504 that developed the basic waveguide setup, process and instruments. Inmore » this project we were investigating the use of MMW to form rock melt and steel plugs in deep wells to further isolate highly radioactive nuclear waste in ultra-deep basement rocks for long term storage. This technology also has potential for deep well drilling for nuclear storage, geothermal and oil and gas industries. It also has the potential for simultaneously sealing and securing the wellbore with a thick rock melt liner as the wellbore is drilled. This allows for higher levels of safety and protection of the environment during deep drilling operations. The larger purpose of this project was to find answers to key questions in progressing MMW technology for these applications. Phase I of this project continued bench testing using the MIT 10 kilo-Watt (kW), 28 GHz frequency laboratory gyrotron, literature searches, planning and design of equipment for Phase II efforts. Furnace melting and rock testing (Tasks 4 and 5) were deferred to Phase II due to lack of concurrent availability of the furnace and personnel at MIT. That delay and lower temperature furnace (limited to 1650oC) caused rethinking of Task 4 to utilize coordinated rock selection with the DOD testing in Phase II. The high pressure and high power window design work (moved to Phase I Task 3 from Phase II Task 20) and Additive materials and methods (Tasks 7 & 8) performed in Phase I may become patentable and thus little detail can be provided in this public report. A version of that new high pressure, high MMW power window may be built for possible Phase II testing at the DOD site. Most significantly, additional tasks were added for planning the use of the Department of Defense, Air Force Research Laboratory’s (DOD-AFRL’s) System 0 gyrotron in Phase II. Specifically added and accomplished were multiple discussions on DOD and DOE-MIT-Impact goals, timing between ongoing DOD testing, outlining the required equipment and instruments for rock testing, and terms for an agreement. That addition required a visit to Kirtland AFB in Albuquerque, New Mexico to talk to key DOD-AFRL personnel and management. A DOD-Impact-MIT charter (i.e., contract) is now being circulated for signatures. Also added task to Phase I, MIT designed the critical path reflected power isolator screen for Phase II testing. To ensure compatibility, that design was computer simulated for the expected heat load distribution and the resulting temperature increase. Advancing the MMW testing up to the optimum 95 GHz and 100kW (5X higher) power levels was stated in the original proposal to be a key required development step for this technology to achieve prototype drilling, lining, and rock melting/ vaporization for creating sealing plugs.« less

European Vaccine Initiative: lessons from developing malaria vaccines.

PubMed

Geels, Mark J; Imoukhuede, Egeruan B; Imbault, Nathalie; van Schooten, Harry; McWade, Terry; Troye-Blomberg, Marita; Dobbelaer, Roland; Craig, Alister G; Leroy, Odile

2011-12-01

For over 10 years, the European Vaccine Initiative (EVI; European Malaria Vaccine Initiative until 2009) has contributed to the development of 24 malaria candidate vaccine antigens with 13 vaccine candidates being advanced into Phase I clinical trials, two of which have been transitioned for further clinical development in sub-Saharan Africa. Since its inception the EVI organization has operated as a funding agency, but with a clear service-oriented strategy. The scientific successes and difficulties encountered during these years and how these efforts have led to standardization and harmonization in vaccine development through large-scale European consortia are discussed. In the future, the EVI will remain instrumental in the pharmaceutical and clinical development of vaccines against 'diseases of poverty' with a continued focus on malaria. EVI will continue to focus on funding and managing preclinical evaluation up to Phase I/II clinical trials and strengthening the vaccine-development infrastructure in Europe, albeit with a global orientation.

Gene expression patterns during somatic embryo development and germination in maize Hi II callus cultures.

PubMed

Che, Ping; Love, Tanzy M; Frame, Bronwyn R; Wang, Kan; Carriquiry, Alicia L; Howell, Stephen H

2006-09-01

Gene expression patterns were profiled during somatic embryogenesis in a regeneration-proficient maize hybrid line, Hi II, in an effort to identify genes that might be used as developmental markers or targets to optimize regeneration steps for recovering maize plants from tissue culture. Gene expression profiles were generated from embryogenic calli induced to undergo embryo maturation and germination. Over 1,000 genes in the 12,060 element arrays showed significant time variation during somatic embryo development. A substantial number of genes were downregulated during embryo maturation, largely histone and ribosomal protein genes, which may result from a slowdown in cell proliferation and growth during embryo maturation. The expression of these genes dramatically recovered at germination. Other genes up-regulated during embryo maturation included genes encoding hydrolytic enzymes (nucleases, glucosidases and proteases) and a few storage genes (an alpha-zein and caleosin), which are good candidates for developmental marker genes. Germination is accompanied by the up-regulation of a number of stress response and membrane transporter genes, and, as expected, greening is associated with the up-regulation of many genes encoding photosynthetic and chloroplast components. Thus, some, but not all genes typically associated with zygotic embryogenesis are significantly up or down-regulated during somatic embryogenesis in Hi II maize line regeneration. Although many genes varied in expression throughout somatic embryo development in this study, no statistically significant gene expression changes were detected between total embryogenic callus and callus enriched for transition stage somatic embryos.

AIAA Aviation UAS DAA Demonstration-Mini HITL Week 2 Stats

NASA Technical Reports Server (NTRS)

Fern, Lisa Carolynn; Murphy, James R.; Jovic, Srboljub

2016-01-01

The UAS-NAS Project demo will showcase recent research efforts to ensure the interoperability between proposed UAS detect and avoid (DAA) human machine interface requirements (developed within RTCA SC-228) and existing collision avoidance displays. Attendees will be able to view the current state of the art of the DAA pilot traffic, alerting and guidance displays integrated with Traffic advisory and Collision Avoidance (TCAS) II in the UAS-NAS Project's research UAS ground control station (developed in partnership with the Air Force Research Laboratory). In addition, attendees will have the opportunity to interact with the research UAS ground control station and "fly" encounters, using the DAA and TCAS II displays to avoid simulated aircraft. The display of the advisories will be hosted on a laptop with an external 30" monitor, running the Vigilant Spririt system. DAA advisories will be generated by the JADEM software tool, connected to the system via the LVC Gateway. A repeater of the primary flight display will be shown on a 55" tv/monitor mounted on a stand at the back of the booth to show the pilot interaction to the passersby.

UAS-NAS Project Demo - Mini HITL Week 2 Stats

NASA Technical Reports Server (NTRS)

Murphy, James R.; Fern, Lisa C.; Rorie, Robert C.; Shively, Robert; Jovic, Srboljub

2016-01-01

The UAS-NAS Project demo will showcase recent research efforts to ensure the interoperability between proposed UAS detect and avoid (DAA) human machine interface requirements (developed within RTCA SC-228) and existing collision avoidance displays. Attendees will be able to view the current state of the art of the DAA pilot traffic, alerting and guidance displays integrated with Traffic advisory and Collision Avoidance (TCAS) II in the UAS-NAS Project's research UAS ground control station (developed in partnership with the Air Force Research Laboratory). In addition, attendees will have the opportunity to interact with the research UAS ground control station and "fly" encounters, using the DAA and TCAS II displays to avoid simulated aircraft. The display of the advisories will be hosted on a laptop with an external 30" monitor, running the Vigilant Spirit system. DAA advisories will be generated by the JADEM software tool, connected to the system via the LVC Gateway. A repeater of the primary flight display will be shown on a 55" monitor mounted on a stand at the back of the booth to show the pilot interaction to the passersby.

An Overview of In-Space Propulsion and Cryogenics Fluids Management Efforts for 2014 SBIR Phases I and II

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2016-01-01

NASA's Small Business Innovation Research (SBIR) program focuses on technological innovation by investing in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for Agency programs. This report highlights 11 of the innovative SBIR 2014 Phase I and II projects from 2010 to 2012 that focus on one of NASA Glenn Research Center's six core competencies-In-Space Propulsion and Cryogenic Fluids Management. The technologies cover a wide spectrum of applications such as divergent field annular ion engines, miniature nontoxic nitrous oxide-propane propulsion, noncatalytic ignition systems for high-performance advanced monopropellant thrusters, nontoxic storable liquid propulsion, and superconducting electric boost pumps for nuclear thermal propulsion. Each article describes an innovation and technical objective and highlights NASA commercial and industrial applications. This report provides an opportunity for NASA engineers, researchers, and program managers to learn how NASA SBIR technologies could help their programs and projects, and lead to collaborations and partnerships between the small SBIR companies and NASA that would benefit both.

Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876

DOE Office of Scientific and Technical Information (OSTI.GOV)

McComas, Casey C.; Palani, Anandan; Chang, Wei

Studies directed at developing a broadly acting non-nucleoside inhibitor of HCV NS5B led to the discovery of a novel structural class of 5-aryl benzofurans that simultaneously interact with both the palm I and palm II binding regions. An initial candidate was potent in vitro against HCV GT1a and GT1b replicons, and induced multi-log reductions in HCV viral load when orally dosed to chronic GT1 infected chimpanzees. However, in vitro potency losses against clinically relevant GT1a variants prompted a further effort to develop compounds with sustained potency across a broader array of HCV genotypes and mutants. Ultimately, a biology and medicinalmore » chemistry collaboration led to the discovery of the development candidate MK-8876. MK-8876 demonstrated a pan-genotypic potency profile and maintained potency against clinically relevant mutants. It demonstrated moderate bioavailability in rats and dogs, but showed low plasma clearance characteristics consistent with once-daily dosing. Herein we describe the efforts which led to the discovery of MK-8876, which advanced into Phase 1 monotherapy studies for evaluation and characterization as a component of an all-oral direct-acting drug regimen for the treatment of chronic HCV infection.« less

DANTi: Detect and Avoid iN The Cockpit

NASA Technical Reports Server (NTRS)

Chamberlain, James; Consiglio, Maria; Munoz, Cesar

2017-01-01

Mid-air collision risk continues to be a concern for manned aircraft operations, especially near busy non-towered airports. The use of Detect and Avoid (DAA) technologies and draft standards developed for unmanned aircraft systems (UAS), either alone or in combination with other collision avoidance technologies, may be useful in mitigating this collision risk for manned aircraft. This paper describes a NASA research effort known as DANTi (DAA iN The Cockpit), including the initial development of the concept of use, a software prototype, and results from initial flight tests conducted with this prototype. The prototype used a single Automatic Dependent Surveillance - Broadcast (ADS-B) traffic sensor and the own aircraft's position, track, heading and air data information, along with NASA-developed DAA software to display traffic alerts and maneuver guidance to manned aircraft pilots on a portable tablet device. Initial flight tests with the prototype showed a successful DANTi proof-of-concept, but also demonstrated that the traffic separation parameter set specified in the RTCA SC-228 Phase I DAA MOPS may generate excessive false alerts during traffic pattern operations. Several parameter sets with smaller separation values were also tested in flight, one of which yielded more timely alerts for the maneuvers tested. Results from this study may further inform future DANTi efforts as well as Phase II DAA MOPS development.

Engineering low-temperature expression systems for heterologous production of cold-adapted enzymes.

PubMed

Bjerga, Gro Elin Kjæreng; Lale, Rahmi; Williamson, Adele Kim

2016-01-01

Production of psychrophilic enzymes in the commonly used mesophilic expression systems is hampered by low intrinsic stability of the recombinant enzymes at the optimal host growth temperatures. Unless strategies for low-temperature expression are advanced, research on psychrophilic enzymes may end up being biased toward those that can be stably produced in commonly used mesophilic host systems. Two main strategies are currently being explored for the development of low-temperature expression in bacterial hosts: (i) low-temperature adaption of existing mesophilic expression systems, and (ii) development of new psychrophilic hosts. These developments include genetic engineering of the expression cassettes to optimize the promoter/operator systems that regulate heterologous expression. In this addendum we present our efforts in the development of such low-temperature expression systems, and speculate about future advancements in the field and potential applications.

Parallel Ada benchmarks for the SVMS

NASA Technical Reports Server (NTRS)

Collard, Philippe E.

1990-01-01

The use of parallel processing paradigm to design and develop faster and more reliable computers appear to clearly mark the future of information processing. NASA started the development of such an architecture: the Spaceborne VHSIC Multi-processor System (SVMS). Ada will be one of the languages used to program the SVMS. One of the unique characteristics of Ada is that it supports parallel processing at the language level through the tasking constructs. It is important for the SVMS project team to assess how efficiently the SVMS architecture will be implemented, as well as how efficiently Ada environment will be ported to the SVMS. AUTOCLASS II, a Bayesian classifier written in Common Lisp, was selected as one of the benchmarks for SVMS configurations. The purpose of the R and D effort was to provide the SVMS project team with the version of AUTOCLASS II, written in Ada, that would make use of Ada tasking constructs as much as possible so as to constitute a suitable benchmark. Additionally, a set of programs was developed that would measure Ada tasking efficiency on parallel architectures as well as determine the critical parameters influencing tasking efficiency. All this was designed to provide the SVMS project team with a set of suitable tools in the development of the SVMS architecture.

Airborne Laser Hydrography II

NASA Astrophysics Data System (ADS)

Philpot, W.; Wozencraft, J.

2016-02-01

In 1985, Dr. Gary Guenther assembled the text, "Airborne Laser Hydrography" which quickly became a heavily used manual and guide for any and all scientists and engineers involved with airborne lidar bathymetry (ALB). It was a remarkable book that captured a snapshot of the state of the art of ALB and included historical developments, theoretical and modeling efforts as well as design characteristics and constraints, ending with accuracy assessment and a discussion of design tradeoffs. Known familiarly as the "Blue Book" it served the community remarkably well for many years. At 30 years of age, it is still a valued reference, but unavoidably dated in a field that has developed rapidly and nonstop over the intervening years. It is time for an update. The new text is attempt by the ALB community to update and expand upon Guenther's text. Like the original, Blue Book II reviews the historical developments in ALB, extending them into the 21st century, considers basic environmental water optical properties, theoretical developments, data processing and performance evaluation. All have progressed dramatically in the past 30 years. This paper presents an outline of the new book, a description of the contents, with emphasis on the theoretical models of the lidar waveform and its propagation through, and interaction with the water.

Silicon Nitride Equation of State

NASA Astrophysics Data System (ADS)

Swaminathan, Pazhayannur; Brown, Robert

2015-06-01

This report presents the development a global, multi-phase equation of state (EOS) for the ceramic silicon nitride (Si3N4) . Structural forms include amorphous silicon nitride normally used as a thin film and three crystalline polymorphs. Crystalline phases include hexagonal α-Si3N4, hexagonalβ-Si3N4, and the cubic spinel c-Si3N4. Decomposition at about 1900 °C results in a liquid silicon phase and gas phase products such as molecular nitrogen, atomic nitrogen, and atomic silicon. The silicon nitride EOS was developed using EOSPro which is a new and extended version of the PANDA II code. Both codes are valuable tools and have been used successfully for a variety of material classes. Both PANDA II and EOSPro can generate a tabular EOS that can be used in conjunction with hydrocodes. The paper describes the development efforts for the component solid phases and presents results obtained using the EOSPro phase transition model to investigate the solid-solid phase transitions in relation to the available shock data. Furthermore, the EOSPro mixture model is used to develop a model for the decomposition products and then combined with the single component solid models to study the global phase diagram. Sponsored by the NASA Goddard Space Flight Center Living With a Star program office.

The Medical Library Association's professional development program: a look back at the way ahead*

PubMed Central

Roper, Fred W.

2006-01-01

Objective: Reflecting patterns evident in past Janet Doe Lectures, the 2005 address reviews the Medical Library Association's (MLA's) professional development activities from their beginnings after World War II. A group of related but separate activities is traced through the establishment of an integrated professional development program. A further objective is to introduce newer members of MLA to their heritage and to remind others how the association has reached this point in its history. Setting: The lecture provides an overview of the evolution of MLA's professional development program—with emphasis on certification and continuing education in the early years. It further reflects briefly on some of the more recent MLA activities that have greatly impacted professional development and underscores some new initiatives. Analysis: The efforts of a virtual who's who of MLA's membership have been responsible for the convergence of the association's efforts over more than half a century to provide a comprehensive professional development program. As a participant in MLA's professional development activities for more than forty years, the 2005 lecturer provides a personal view of the growth and expansion of the program. Conclusions: Professional development has been a hallmark of MLA for many years. The association's challenge is to continue to develop creative and innovative programs, to continuously review and revise existing programs, and to have the vision and vitality to maintain a viable program that will provide the membership with the knowledge and skills needed to function effectively now and in the future. PMID:16404465

U.S. Federal Investments in Climate Change Education: They're Warming Up! (Invited)

NASA Astrophysics Data System (ADS)

Karsten, J. L.; Niepold, F.; Wei, M.; Usgcrp Education Interagency Working Group

2010-12-01

Many similarities exist between the U.S. federal government and the climate system, in terms of their complexity. Government operates through a dynamic interplay of sub-systems (different agencies), pressure gradients (political interests), energy transformations (converting dollars into activity through Congressional appropriations, grants and contracts), and non-linear positive and negative feedback mechanisms (MOU’s, competing agency missions). ‘Viscosity’ in the system makes progress difficult. The good news is that, like the climate, federal investments in climate change education are heating up, due to man-made inputs. Individual agency investments in projects to improve and monitor public understanding of climate change and its impacts are rapidly becoming more coupled and coherent. This paper will discuss several efforts now underway. In FY 2009, dedicated, multi-million dollar funding led to creation of NSF’s Climate Change Education (CCE) and NASA’s Global Climate Change Education (GCCE) grant programs, which are funding a projects to develop pedagogically-sound learning resources, professional development strategies, tool kits, and web-based clearinghouses offering scientifically accurate information about climate change to different learner audiences. NOAA has been able to firmly establish their Environmental Literacy Grant (ELG) program because of the America COMPETES Act. Related programs are being developed within the EPA and USDA’s NIFA and U.S. Forest Service. Several other agencies have revamped their strategic plans to increase focus on communicating with and educating teachers, students, policymakers, and the general public about climate change, adaptation, and mitigation issues. To foster larger networks of scientists and educators, minimize duplication, and encourage synergy and scale-up, NSF, NOAA, and NASA have initiated joint meetings of their CCE, GCCE, and ELG Principal Investigators and shared evaluations. Additional cross-agency linkages are being encouraged through NSF’s new Climate Change Education Partnership (CCEP) program, which launched 15 Phase I Partnerships focused around specific geographic regions or scientific themes unified by common climate change impacts. When fully implemented in Phase II, CCEP expects to increase the adoption of high quality educational resources and their impact on public climate literacy. Phase I strategic planning efforts will identify and engage relevant stakeholders, inventory existing climate change education resources for that theme or region, conduct a needs analysis, and develop a robust strategic plan for implementation in Phase II. The U.S. Global Change Research Program (USGCRP) is the primary organizational structure through which the 13 federal agencies that conduct climate-related research, education, and outreach are coordinating their efforts. The Climate Literacy framework is one example of the constructive collaboration that has been achieved through the USGCRP Education Interagency Working Group. Additional efforts are being planned through a new Interagency Climate Communication and Education Task Force.

Review and Evaluation of Current Training Programs Found in Various Mining Environments. Final Report. Volume II, Analysis and Recommendations.

ERIC Educational Resources Information Center

Adkins, John; And Others

A project was designed to produce a broad description of current mining training programs and to evaluate their effectiveness with respect to reducing mine injuries. Aggregate training and injury data were used to evaluate the overall training effort at 300 mines as well as specific efforts in 12 categories of training course objectives. From such…

Fuel-Flexible Gasification-Combustion Technology for Production of H2 and Sequestration-Ready CO2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parag Kulkarni; Jie Guan; Raul Subia

In the near future, the nation will continue to rely on fossil fuels for electricity, transportation, and chemicals. It is necessary to improve both the process efficiency and environmental impact of fossil fuel utilization including greenhouse gas management. GE Global Research (GEGR) investigated an innovative fuel-flexible Unmixed Fuel Processor (UFP) technology with potential to produce H{sub 2}, power, and sequestration-ready CO{sub 2} from coal and other solid fuels. The UFP technology offers the long-term potential for reduced cost, increased process efficiency relative to conventional gasification and combustion systems, and near-zero pollutant emissions. GE was awarded a contract from U.S. DOEmore » NETL to investigate and develop the UFP technology. Work started on the Phase I program in October 2000 and on the Phase II effort in April 2005. In the UFP technology, coal, water and air are simultaneously converted into (1) hydrogen rich stream that can be utilized in fuel cells or turbines, (2) CO{sub 2} rich stream for sequestration, and (3) high temperature/pressure vitiated air stream to produce electricity in a gas turbine expander. The process produces near-zero emissions with an estimated efficiency higher than Integrated Gasification Combined Cycle (IGCC) process with conventional CO{sub 2} separation. The Phase I R&D program established the chemical feasibility of the major reactions of the integrated UFP technology through lab-, bench- and pilot-scale testing. A risk analysis session was carried out at the end of Phase I effort to identify the major risks in the UFP technology and a plan was developed to mitigate these risks in the Phase II of the program. The Phase II effort focused on three high-risk areas: economics, lifetime of solids used in the UFP process, and product gas quality for turbines (or the impact of impurities in the coal on the overall system). The economic analysis included estimating the capital cost as well as the costs of hydrogen and electricity for a full-scale UFP plant. These costs were benchmarked with IGCC polygen plants with similar level of CO{sub 2} capture. Based on the promising economic analysis comparison results (performed with the help from Worley Parsons), GE recommended a 'Go' decision in April 2006 to continue the experimental investigation of the UFP technology to address the remaining risks i.e. solids lifetime and the impact of impurities in the coal on overall system. Solids attrition and lifetime risk was addressed via bench-scale experiments that monitor solids performance over time and by assessing materials interactions at operating conditions. The product gas under the third reactor (high-temperature vitiated air) operating conditions was evaluated to assess the concentration of particulates, pollutants and other impurities relative to the specifications required for gas turbine feed streams. During this investigation, agglomeration of solids used in the UFP process was identified as a serious risk that impacts the lifetime of the solids and in turn feasibility of the UFP technology. The main causes of the solids agglomeration were the combination of oxygen transfer material (OTM) reduction at temperatures {approx}1000 C and interaction between OTM and CO{sub 2} absorbing material (CAM) at high operating temperatures (>1200 C). At the end of phase II, in March 2008, GEGR recommended a 'No-go' decision for taking the UFP technology to the next level of development, i.e. development of a 3-5 MW prototype system, at this time. GEGR further recommended focused materials development research programs on improving the performance and lifetime of solids materials used in UFP or chemical looping technologies. The scale-up activities would be recommended only after mitigating the risks involved with the agglomeration and overall lifetime of the solids. This is the final report for the phase II of the DOE-funded Vision 21 program entitled 'Fuel-Flexible Gasification-Combustion Technology for Production of H{sub 2} and Sequestration-Ready CO{sub 2}' (DOE Award No. DE-FC26-00NT40974). The report focuses on the major accomplishments and lessons learned in analyzing the risks of the novel UFP technology during Phase II of the DOE program.« less

DebriSat Fragment Characterization System and Processing Status

NASA Technical Reports Server (NTRS)

Rivero, M.; Shiotani, B.; M. Carrasquilla; Fitz-Coy, N.; Liou, J. C.; Sorge, M.; Huynh, T.; Opiela, J.; Krisko, P.; Cowardin, H.

2016-01-01

The DebriSat project is a continuing effort sponsored by NASA and DoD to update existing break-up models using data obtained from hypervelocity impact tests performed to simulate on-orbit collisions. After the impact tests, a team at the University of Florida has been working to characterize the fragments in terms of their mass, size, shape, color and material content. The focus of the post-impact effort has been the collection of 2 mm and larger fragments resulting from the hypervelocity impact test. To date, in excess of 125K fragments have been recovered which is approximately 40K more than the 85K fragments predicted by the existing models. While the fragment collection activities continue, there has been a transition to the characterization of the recovered fragments. Since the start of the characterization effort, the focus has been on the use of automation to (i) expedite the fragment characterization process and (ii) minimize the effects of human subjectivity on the results; e.g., automated data entry processes were developed and implemented to minimize errors during transcription of the measurement data. At all steps of the process, however, there is human oversight to ensure the integrity of the data. Additionally, repeatability and reproducibility tests have been developed and implemented to ensure that the instrumentations used in the characterization process are accurate and properly calibrated.

Development of 0.5-5 W, 10K Reverse Brayton Cycle Cryocoolers - Phase II Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doty, F. D.; Boman, A.; Arnold, S.

2001-10-15

Miniature cryocoolers for the 8-30 K range are needed to provide 0.5-5 w of cooling to high sensitivity detectors (for long-wave-length IR, magnetism, mm-wave, X-ray, dark matter, and possibly y-ray detection) while maintaining low mass, ultra-low vibration, and good efficiency. This project presents a new approach to eliminating the problems normally encountered in efforts to build low-vibration, fieldable, miniature cryocoolers. Using the reverse Brayton Cycle (RBC), the approach applies and expands on existing spinner technology previously used only in Nuclear Magnetic Resonance (NMR) probes.

The Development of an Advanced Anti-Icing/Deicing Capability for U.S. Army Helicopters. Volume II. Ice Protection System Application to the UH-1H helicopter

DTIC Science & Technology

1975-11-01

Project Lfgineer for this effort was ]Richard I. Adin of tL* eta ~ ’ -’ ’. -. - " - -ý - - , I - OWLAMWRS The 01 Mp io Otis vap am wae to No conmved an...area. One is the ultrasonic type and the second is the infrared occlusion type. Both sensors include aspirators using engine compressor bleed air to...half pound per minute of enginie bleed air to operate the aspirator . The principal benefit of the aspiration is during hover, as there is sufficient

PHASE II CALDERON PROCESS TO PRODUCE DIRECT REDUCED IRON RESEARCH AND DEVELOPMENT PROJECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albert Calderon

2003-04-28

This project was initially targeted to the making of coke for blast furnaces by using proprietary technology of Calderon in a phased approach, and Phase I was successfully completed. The project was then re-directed to the making of iron units. U.S. Steel teamed up with Calderon for a joint effort which will last 30 months to produce directly reduced iron with the potential of converting it into molten iron or steel consistent with the Roadmap recommendations of 1998 prepared by the Steel Industry in cooperation with the Department of Energy.

PHASE II CALDERON PROCESS TO PRODUCE DIRECT REDUCED IRON RESEARCH AND DEVELOPMENT PROJECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albert Calderon

2003-01-28

This project was initially targeted to the making of coke for blast furnaces by using proprietary technology of Calderon in a phased approach, and Phase I was successfully completed. The project was then re-directed to the making of iron units. U.S. Steel teamed up with Calderon for a joint effort which will last 30 months to produce directly reduced iron with the potential of converting it into molten iron or steel consistent with the Roadmap recommendations of 1998 prepared by the Steel Industry in cooperation with the Department of Energy.

America's fertile frontier: how America surpassed Britain in the development and growth of plastic surgery during the interwar years of 1920-1940.

PubMed

Fraser, James F; Hultman, Charles Scott

2010-05-01

Most historians agree that modern plastic surgery was born out of the efforts of reconstructive surgeons in World War I (WW I). In a single British hospital, over 8000 wounded soldiers were treated for disfiguring facial wounds. These gruesome injuries provided surgeons with enough cases to make unprecedented advances in tissue reconstruction. After the war, however, surgeons returned to civilian society where they found relatively few cases to support their new niche. In England, plastic surgery failed to establish itself while, in the United States, plastic surgeons had much greater success in founding their new specialty. Emphasizing this trend is the staggering statistic that, at the outbreak of World War II (WW II), the US boasted 60 trained plastic surgeons compared with only 4 in Britain. This article analyzes a variety of primary sources (speeches, journal articles, letters, and live interviews) obtained from several libraries and special collections to argue that the relative success of US plastic surgery in the interwar period (1920-1940) can be attributed to (1) the efforts of pioneering American plastic surgeons (Varaztad Kazanjian, Vilray Blair, and John Davis), (2) the post-Flexner report restructuring of US medical training, and (3) a much warmer reception both by the US public and general surgical community to plastic surgery.

Teaching about Rosie the Riveter: The Role of Women during World War II.

ERIC Educational Resources Information Center

Anderson, Karen

1988-01-01

Discusses a neglected area of U.S. history: the impact of World War II on the role and status of women. Shows how women's work in the home and in the community assisted the national defense effort, and examined the way that changes in employment opportunities affected traditional ideas about women's roles and fostered the modern women's movement.…

A Brief Description of the Purposes and Concepts of the Coursewriter II Preprocessor. System Memo Number Four.

ERIC Educational Resources Information Center

Mitchell, Ron; Conner Michael

A brief description of the Coursewriter II preprocessor is provided. This preprocessor, a program written in FORTRAN IV on the CDC 6600 computer, is designed to reduce the repetition of effort that takes place from the time of the author's conception of a course to the time of its availability for on-line student instruction. The programer deals…

Development of InCVAX as a novel in situ autologous vaccine for metastatic cancers (Conference Presentation)

NASA Astrophysics Data System (ADS)

Hode, Tomas; Alleruzzo, Luciano; Raker, Joseph; Lam, Samuel Siu Kit; Nordquist, Robert E.; Chen, Wei R.

2016-03-01

A novel method, an in situ autologous whole-cell cancer vaccine (inCVAX), is being developed by Immunophotonics, Inc., for the treatment of metastatic cancers. inCVAX combines phototherapy and immunotherapy to potentially induce a systemic anti-tumor immune response in the hosts. Immunophotonics and its academic partners have spent years conducting nonclinical research, developing CMC techniques and conducting clinical research. In 2015 the company initiated a late-stage (II/III) clinical trial in South America for advanced breast cancer patients. The process of developing the inCVAX approach from a laboratory setting into clinical trials requires significant efforts from a group of dedicated engineers, scientists, and physicians. The growth of the company and its business advances demonstrated the determination of a group of visionary investors, entrepreneurs, and business leaders. This talk will chronicle the milestones of the scientific achievement, medical progress, and business development of Immunophotonics.

DoE Phase II SBIR: Spectrally-Assisted Vehicle Tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Villeneuve, Pierre V.

2013-02-28

The goal of this Phase II SBIR is to develop a prototype software package to demonstrate spectrally-aided vehicle tracking performance. The primary application is to demonstrate improved target vehicle tracking performance in complex environments where traditional spatial tracker systems may show reduced performance. Example scenarios in Figure 1 include a) the target vehicle obscured by a large structure for an extended period of time, or b), the target engaging in extreme maneuvers amongst other civilian vehicles. The target information derived from spatial processing is unable to differentiate between the green versus the red vehicle. Spectral signature exploitation enables comparison ofmore » new candidate targets with existing track signatures. The ambiguity in this confusing scenario is resolved by folding spectral analysis results into each target nomination and association processes. Figure 3 shows a number of example spectral signatures from a variety of natural and man-made materials. The work performed over the two-year effort was divided into three general areas: algorithm refinement, software prototype development, and prototype performance demonstration. The tasks performed under this Phase II to accomplish the program goals were as follows: 1. Acquire relevant vehicle target datasets to support prototype. 2. Refine algorithms for target spectral feature exploitation. 3. Implement a prototype multi-hypothesis target tracking software package. 4. Demonstrate and quantify tracking performance using relevant data.« less

Failsafe automation of Phase II clinical trial interim monitoring for stopping rules.

PubMed

Day, Roger S

2010-02-01

In Phase II clinical trials in cancer, preventing the treatment of patients on a study when current data demonstrate that the treatment is insufficiently active or too toxic has obvious benefits, both in protecting patients and in reducing sponsor costs. Considerable efforts have gone into experimental designs for Phase II clinical trials with flexible sample size, usually implemented by early stopping rules. The intended benefits will not ensue, however, if the design is not followed. Despite the best intentions, failures can occur for many reasons. The main goal is to develop an automated system for interim monitoring, as a backup system supplementing the protocol team, to ensure that patients are protected. A secondary goal is to stimulate timely recording of patient assessments. We developed key concepts and performance needs, then designed, implemented, and deployed a software solution embedded in the clinical trials database system. The system has been in place since October 2007. One clinical trial tripped the automated monitor, resulting in e-mails that initiated statistician/investigator review in timely fashion. Several essential contributing activities still require human intervention, institutional policy decisions, and institutional commitment of resources. We believe that implementing the concepts presented here will provide greater assurance that interim monitoring plans are followed and that patients are protected from inadequate response or excessive toxicity. This approach may also facilitate wider acceptance and quicker implementation of new interim monitoring algorithms.

Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccines.

PubMed

Tobias, Joshua; Svennerholm, Ann-Mari; Holmgren, Jan; Lebens, Michael

2010-07-01

Enterotoxigenic Escherichia coli (ETEC) are an important cause of diarrheal morbidity in developing countries, especially in children and also of traveler's diarrhea. Colonization factors (CFs) of ETEC, like CFA/I and CS2 which are genetically and structurally related, play a substantial role in pathogenicity, and since intestinal-mucosal immune responses against CFs appear to be protective, much effort has focused on the development of a CF-based ETEC vaccine. We have constructed hybrid operons in which the major CS2 subunit-encoding cotA gene was inserted into the CFA/I operon, either replacing (hybrid I) or being added to the major CFA/I subunit-encoding cfaB gene (hybrid II). Using specific monoclonal antibodies against the major subunits of CFA/I and CS2, high levels of surface expression of both fimbrial subunits were shown in E. coli carrying the hybrid II operon. Oral immunization of mice with formalin-killed bacteria expressing hybrid II fimbriae induced strong CFA/I- and CS2-specific serum IgG + IgM and fecal IgA antibody responses, which were higher than those achieved by similar immunization with the reference strains. Bacteria expressing hybrid fimbriae are potential candidate strains in an oral-killed CF-ETEC vaccine, and the approach represents an attractive and novel means of producing a broad-spectrum ETEC vaccine.

Optimizing larval assessment to support sea lamprey control in the Great Lakes

USGS Publications Warehouse

Hansen, Michael J.; Adams, Jean V.; Cuddy, Douglas W.; Richards, Jessica M.; Fodale, Michael F.; Larson, Geraldine L.; Ollila, Dale J.; Slade, Jeffrey W.; Steeves, Todd B.; Young, Robert J.; Zerrenner, Adam

2003-01-01

Elements of the larval sea lamprey (Petromyzon marinus) assessment program that most strongly influence the chemical treatment program were analyzed, including selection of streams for larval surveys, allocation of sampling effort among stream reaches, allocation of sampling effort among habitat types, estimation of daily growth rates, and estimation of metamorphosis rates, to determine how uncertainty in each element influenced the stream selection program. First, the stream selection model based on current larval assessment sampling protocol significantly underestimated transforming sea lam-prey abundance, transforming sea lampreys killed, and marginal costs per sea lamprey killed, compared to a protocol that included more years of data (especially for large streams). Second, larval density in streams varied significantly with Type-I habitat area, but not with total area or reach length. Third, the ratio of larval density between Type-I and Type-II habitat varied significantly among streams, and that the optimal allocation of sampling effort varied with the proportion of habitat types and variability of larval density within each habitat. Fourth, mean length varied significantly among streams and years. Last, size at metamorphosis varied more among years than within or among regions and that metamorphosis varied significantly among streams within regions. Study results indicate that: (1) the stream selection model should be used to identify streams with potentially high residual populations of larval sea lampreys; (2) larval sampling in Type-II habitat should be initiated in all streams by increasing sampling in Type-II habitat to 50% of the sampling effort in Type-I habitat; and (3) methods should be investigated to reduce uncertainty in estimates of sea lamprey production, with emphasis on those that reduce the uncertainty associated with larval length at the end of the growing season and those used to predict metamorphosis.

Silylated Acid Hardened Resist [SAHR] Technology: Positive, Dry Developable Deep UV Resists

NASA Astrophysics Data System (ADS)

Thackeray, James W.; Bohland, John F.; Pavelchek, , Edward K.; Orsula, George W.; McCullough, Andrew W.; Jones, Susan K.; Bobbio, Stephen M.

1990-01-01

This paper describes continuing efforts in the development of Acid Hardened Resist (AHR) systems for use in deep UV photolithography. The Silylated AHR (SAHR) process treats a highly absorbing resist, such as XP-8928, with trimethylsilyldiethylamine. The exposed, crosslinked areas show virtually no reactivity with the silylating agent, and the unexposed areas incorporate 10 to 12% by weight silicon in the film. The silicon appears to incorporate from the exterior in a constant concentration, consistent with Case II diffusion. Subsequent dry etching leads to a positive tone image. The contrast is 5, and the photospeed is ~10 mJ/cm2. Resolution of 0.5 μm line/space pairs has been demonstrated, although substantial proximity effects are encountered.

Automating Embedded Analysis Capabilities and Managing Software Complexity in Multiphysics Simulation, Part II: Application to Partial Differential Equations

DOE PAGES

Pawlowski, Roger P.; Phipps, Eric T.; Salinger, Andrew G.; ...

2012-01-01

A template-based generic programming approach was presented in Part I of this series of papers [Sci. Program. 20 (2012), 197–219] that separates the development effort of programming a physical model from that of computing additional quantities, such as derivatives, needed for embedded analysis algorithms. In this paper, we describe the implementation details for using the template-based generic programming approach for simulation and analysis of partial differential equations (PDEs). We detail several of the hurdles that we have encountered, and some of the software infrastructure developed to overcome them. We end with a demonstration where we present shape optimization and uncertaintymore » quantification results for a 3D PDE application.« less

Evaluation of hydrothermal resources of North Dakota. Phase II. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, K.L.; Howell, F.L.; Winczewski, L.M.

1981-06-01

The Phase II activities dealt with three main topical areas: geothermal gradient and heat-flow studies, stratigraphic studies, and water quality studies. Efforts were concentrated on Mesozoic and Cenozoic rocks. The geothermal gradient and heat-flow studies involved running temperature logs in groundwater observation holes in areas of interest, and locating, obtaining access to, and casing holes of convenience to be used as heat-flow determination sites. The stratigraphic and water quality studies involved two main efforts: updating and expanding WELLFILE and assembling a computer library system (WELLCAT) for all water wells drilled in the state. WATERCAT combines data from the United Statesmore » Geological Survey Water Resources Division's WATSTOR and GWST computer libraries; and includes physical, stratigraphic, and water quality data. Goals, methods, and results are presented.« less

Historical review of missile aerodynamic developments

NASA Technical Reports Server (NTRS)

Spearman, M. Leroy

1989-01-01

The development of missiles from early history up to about 1970 is discussed. Early unpowered missiles beyond the rock include the spear, the bow and arrow, the gun and bullet, and the cannon and projectile. Combining gunpowder with projectiles resulted in the first powered missiles. In the early 1900's, the development of guided missiles was begun. Significant advances in missile technology were made by German scientists during World War II. The dispersion of these advances to other countries following the war resulted in accelerating the development of guided missiles. In the late 1940's and early 1950's there was a proliferation in the development of missile systems in many countries. These developments were based primarily on experimental work and on relatively crude analytical techniques. Discussed here are some of the missile systems that were developed up to about 1970; some of the problems encountered; the development of an experimental data base for use with missiles; and early efforts to develop analytical methods applicable to missiles.

Multisurface modeling of Ni bioavailability to wheat (Triticum aestivum L.) in various soils.

PubMed

Zhao, Xiaopeng; Jiang, Yang; Gu, Xueyuan; Gu, Cheng; Taylor, J Anita; Evans, Les J

2018-07-01

Continual efforts have been made to determine a simple and universal method of estimating heavy metal phytoavailability in terrestrial systems. In the present study, a mechanism-based multi-surface model (MSM) was developed to predict the partition of Ni(II) in soil-solution phases and its bioaccumulation in wheat (Triticum aestivum L.) in 19 Chinese soils with a wide range of soil properties. MSM successfully predicted the Ni(II) dissolution in 0.01 M CaCl 2 extracting solution (R 2  = 0.875). The two-site model for clay fraction improved the prediction, particularly for alkaline soils, because of the additional consideration of edge sites. More crucially, the calculated dissolved Ni(II) was highly correlated with the metal accumulation in wheat (R 2  = 0.820 for roots and 0.817 for shoots). The correlation coefficients for the MSM and various chemical extraction methods have the following order: soil pore water > MSM ≈ diffuse gradient technique (DGT) > soil total Ni > 0.43 M HNO 3  > 0.01 M CaCl 2 . The results suggested that the dissolved Ni(II) calculated using MSM can serve as an effective indicator of the bioavailability of Ni(II) in various soils; hence, MSM can be used as an supplement for metal risk prediction and assessment besides chemical extraction techniques. Copyright © 2018 Elsevier Ltd. All rights reserved.

HPC Access Using KVM over IP

DTIC Science & Technology

2007-06-01

these devices coupled with the difficulties- working with IP Video Systems (formerly Teraburst and cost-of installing dedicated long-distance fiber optic...dedicated fiber is best revealed that the IP Video Systems solutions seem to be suited for installation for point-to-point communications. the best...Research completion of the SBIR Phase II effort is planned for late (SBIR) effort with IP Video Systems (formerly known as FY 07. This paper will discuss

Portraits of the Changes, the Players, and the Contexts. A Study of Dissemination Efforts Supporting School Improvement. People, Policies, and Practices: Examining the Chain of School Improvement, Volume II.

ERIC Educational Resources Information Center

Loucks, Susan F.; And Others

Based on a local site sample of 146 school districts, this volume (the second in a series of 10) describes school improvement efforts supported by 4 different federal strategies and representative programs: interpersonal linkage of validated practices (National Diffusion Network), commercial distribution (Bureau of Education for the Handicapped…

38 CFR 21.184 - “Evaluation and planning” status.

Code of Federal Regulations, 2010 CFR

2010-07-01

... prior initial evaluations, or (ii) Current or previous individualized rehabilitation plans. (b... every reasonable effort to enable the veteran to complete the evaluation and planning phase of the...

National poverty reduction strategies and HIV/AIDS governance in Malawi: a preliminary study of shared health governance.

PubMed

Wachira, Catherine; Ruger, Jennifer Prah

2011-06-01

The public health and development communities understand clearly the need to integrate anti-poverty efforts with HIV/AIDS programs. This article reports findings about the impact of the Poverty Reduction Strategy Paper (PRSP) process on Malawi's National HIV/AIDS Strategic Framework (NSF). In this article we ask, how does the PRSP process support NSF accountability, participation, access to information, funding, resource planning and allocation, monitoring, and evaluation? In 2007, we developed and conducted a survey of Malawian government ministries, United Nations agencies, members of the Country Coordination Mechanism, the Malawi National AIDS Commission (NAC), and NAC grantees (N = 125, 90% response rate), seeking survey respondents' retrospective perceptions of NSF resource levels, participation, inclusion, and governance before, during, and after Malawi's PRSP process (2000-2004). We also assessed principle health sector and economic indicators and budget allocations for HIV/AIDS. These indicators are part of a new conceptual framework called shared health governance (SHG), which seeks congruence among the values and goals of different groups and actors to reflect a common purpose. Under this framework, global health policy should encompass: (i) consensus among global, national, and sub-national actors on goals and measurable outcomes; (ii) mutual collective accountability; and (iii) enhancement of individual and group health agency. Indicators to assess these elements included: (i) goal alignment; (ii) adequate resource levels; (iii) agreement on key outcomes and indicators for evaluating those outcomes; (iv) meaningful inclusion and participation of groups and institutions; (v) special efforts to ensure participation of vulnerable groups; and (vi) effectiveness and efficiency measures. Results suggest that the PRSP process supported accountability for NSF resources. However, the process may have marginalized key stakeholders, potentially undercutting the implementation of HIV/AIDS Action Plans. Copyright © 2010. Published by Elsevier Ltd.

Relativistic solar particle events during STIP (study of travelling interplanetary phenomena) intervals II and IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shea, M.A.; Smart, D.F.

1982-12-27

Using spaceship 'Earth' as a detector located at 1 AU, the relativistic solar cosmic ray events of 30 April 1976 and 22 November 1977 are compared to deduce the relativistic solar particle flux anisotropy and pitch angle characteristics in the interplanetary medium. These two ground level events occurred during STIP Interval II and IV respectively - periods of time of coordinated and cooperative scientific efforts.

Through My Eyes: A Child's View of World War II. Appropriate for Grades 5-8.

ERIC Educational Resources Information Center

Brooks, Margaret

This activity book is designed for grades 5-8 to look at America at home during World War II. The work examines the efforts of the men, women, and children who supported and supplied one of the greatest mobilizations of people and material that the world has ever witnessed. The activities were planned to compliment the exhibit of the same name,…

Pharmacotherapy of amphetamine-type stimulant dependence: an update.

PubMed

Brensilver, Matthew; Heinzerling, Keith G; Shoptaw, Steven

2013-09-01

Methamphetamine- or amphetamine-type stimulants are the second most frequently used illicit drug worldwide, second only to cannabis. Behavioural treatments are efficacious, but their impact is limited underscoring the need for other treatment options, notably, pharmacotherapy. A review of randomised controlled trials of pharmacotherapies for methamphetamine- or amphetamine-type stimulants was performed using PubMed and Google Scholar databases. Evidence for efficacy of medications is reported. Clinical trials have yielded no broadly effective pharmacotherapy. Promising signals have been observed for methylphenidate, naltrexone, bupropion and mirtazapine in subgroups of patients in reducing stimulant use (e.g. patients with less severe dependence at baseline and men who have sex with men), though none has produced an unambiguous, replicable signal of efficacy. Problems in Phase II trials, including high dropout rates, missing data and a lack of agreement on outcomes, complicate efforts to find a broadly effective pharmacotherapy for amphetamine-type stimulant disorders. Efforts to address these problems include calls for better validation of pharmacological target exposure, receptor binding and functional modulation. As well, there is a need for agreement in using findings from preclinical and early phases of the medication development process for selecting better pharmacotherapy candidates. After over 20 years of efforts worldwide to develop a broadly effective medication for dependence on methamphetamine- or amphetamine-type stimulants, no candidate has emerged. This highlights the need for new compounds, consistent and stringent research methods, better integration between preclinical and clinical stages of medication development, and improved collaboration between government, industry and researchers. © 2013 Australasian Professional Society on Alcohol and other Drugs.

Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance

PubMed Central

2012-01-01

Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public health response. A comprehensive effort, involving the collaboration of 188 scientists (>85% from P.R. China) from 48 different institutions and universities (80% from P.R. China), covers this collection of 29 articles published in Parasites & Vectors. The research mainly stems from a research project entitled “Surveillance and diagnostic tools for major parasitic diseases in P.R. China” (grant no. 2008ZX10004-011) and highlights the frontiers of research in parasitology. The majority of articles in this thematic series deals with the most important parasitic diseases in P.R. China, emphasizing Schistosoma japonicum, Plasmodium vivax and Clonorchis sinensis plus some parasites of emerging importance such as Angiostrongylus cantonensis. Significant achievements have been made through the collaborative research programme in the following three fields: (i) development of strategies for the national control programme; (ii) updating the surveillance data of parasitic infections both in human and animals; and (iii) improvement of existing, and development of novel, diagnostic tools to detect parasitic infections. The progress is considerable and warrants broad validation efforts. Combined with the development of improved tools for diagnosis and surveillance, integrated and multi-pronged control strategies should now pave the way for elimination of parasitic diseases in P.R. China. Experiences and lessons learned can stimulate control and elimination efforts of parasitic diseases in other parts of the world. PMID:23036110

Improving Quality of Seal Leak Test Product using Six Sigma

NASA Astrophysics Data System (ADS)

Luthfi Malik, Abdullah; Akbar, Muhammad; Irianto, Dradjad

2016-02-01

Seal leak test part is a polyurethane material-based product. Based on past data, defect level of this product was 8%, higher than the target of 5%. Quality improvement effort was done using six sigma method that included phases of define, measure, analyse, improve, and control. In the design phase, a Delphi method was used to identify factors that were critical to quality. In the measure phase, stability and process capability was measured. Fault tree analysis (FTA) and failure mode and effect analysis (FMEA) were used in the next phase to analize the root cause and to determine the priority issues. Improve phase was done by compiling, selecting, and designing alternative repair. Some improvement efforts were identified, i.e. (i) making a checklist for maintenance schedules, (ii) making written reminder form, (iii) modifying the SOP more detail, and (iv) performing a major service to the vacuum machine. To ensure the continuity of improvement efforts, some control activities were executed, i.e. (i) controlling, monitoring, documenting, and setting target frequently, (ii) implementing reward and punishment system, (iii) adding cleaning tool, and (iv) building six sigma organizational structure.

Deliberate practice theory: perceived relevance, effort, and inherent enjoyment of music practice: study II.

PubMed

Hyllegard, Randy; Bories, Tamara L

2009-10-01

This study, based on the theory of deliberate practice, examined the practice relevance, effort, and inherent enjoyment aspects of the theory. 25 college undergraduates practiced playing a melody on an electronic keyboard for three 20-min. practice sessions. Following each session, the perceived relevance of the practice for improving performance of the melody, the effort needed to learn the melody, and the inherent enjoyment of the practice were each rated on 10-point scales. Findings were consistent with theory and similar to previous studies also involving music practice and other tasks.

Stratospheric Aerosol and Gas Experiment (SAGE) II and III Aerosol Extinction Measurements in the Arctic Middle and Upper Troposphere

NASA Technical Reports Server (NTRS)

Treffeisen, R. E.; Thomason, L. W.; Strom, J.; Herber, A. B.; Burton, S. P.; Yamanouchi, T.

2006-01-01

In recent years, substantial effort has been expended toward understanding the impact of tropospheric aerosols on Arctic climate and chemistry. A significant part of this effort has been the collection and documentation of extensive aerosol physical and optical property data sets. However, the data sets present significant interpretive challenges because of the diverse nature of these measurements. Among the longest continuous records is that by the spaceborne Stratospheric Aerosol and Gas Experiment (SAGE) II. Although SAGE tropospheric measurements are restricted to the middle and upper troposphere, they may be able to provide significant insight into the nature and variability of tropospheric aerosol, particularly when combined with ground and airborne observations. This paper demonstrates the capacity of aerosol products from SAGE II and its follow-on experiment SAGE III to describe the temporal and vertical variations of Arctic aerosol characteristics. We find that the measurements from both instruments are consistent enough to be combined. Using this combined data set, we detect a clear annual cycle in the aerosol extinction for the middle and upper Arctic troposphere.

Flight Validation of a Metrics Driven L(sub 1) Adaptive Control

NASA Technical Reports Server (NTRS)

Dobrokhodov, Vladimir; Kitsios, Ioannis; Kaminer, Isaac; Jones, Kevin D.; Xargay, Enric; Hovakimyan, Naira; Cao, Chengyu; Lizarraga, Mariano I.; Gregory, Irene M.

2008-01-01

The paper addresses initial steps involved in the development and flight implementation of new metrics driven L1 adaptive flight control system. The work concentrates on (i) definition of appropriate control driven metrics that account for the control surface failures; (ii) tailoring recently developed L1 adaptive controller to the design of adaptive flight control systems that explicitly address these metrics in the presence of control surface failures and dynamic changes under adverse flight conditions; (iii) development of a flight control system for implementation of the resulting algorithms onboard of small UAV; and (iv) conducting a comprehensive flight test program that demonstrates performance of the developed adaptive control algorithms in the presence of failures. As the initial milestone the paper concentrates on the adaptive flight system setup and initial efforts addressing the ability of a commercial off-the-shelf AP with and without adaptive augmentation to recover from control surface failures.

Third-world development: urbanizing for the future.

PubMed

Mcilwaine, C

1997-01-01

This article reviews some issues reflected in the 1996 UN Habitat II agenda and recent research on urbanization. The themes of the 1996 Habitat conference were urban development, urban poverty, and governance, civil society, and social capital. It is expected that over 50% of total world population will live in cities in the year 2000. Cities are viewed both as engines of economic growth and centers of severe economic, environmental, and social problems. There is some disagreement about whether cities are rational economic structures or what the World Bank's urban agenda is and its relationship with macroeconomic policy. Discussions of global urban issues are criticized for their neglect of issues of equity and poverty, cultural diversity, and identity and representation. Habitat II also stressed urban sustainability. There is growing recognition that urban management involves more than the "Brown Agenda" of environmental and physical aspects of urban growth. Recent studies identify how politics and power affect people's access to basic urban services. Urban economic activity can also contribute to environmental problems. Urban growth affects the provision of health services. Although there is not a consensus on the role of cities in expanding economic and social development and the best management practices, there is sufficient evidence to indicate that urban processes are varied throughout the developing world. The links between urban and rural areas differentiate cities and expose the need to understand the role of intermediate urban areas surrounding and between larger cities. Poverty has become increasingly urbanized, but the extent of poverty is unknown. Habitat II was an unprecedented effort to engage nongovernment groups, local government staff, trade unions, and the private sector and to emphasize community participation. Networks of trust and reciprocity are key to solving poverty, inequality, and disempowerment problems.

Private-public sector co-operation to improve pesticide safety standards in developing countries.

PubMed

Ellis, W W

1998-01-01

This paper draws on the author's experiences of the pilot phase of the Safe Use Project (SUP) in Thailand; this project is a part of a major GIFAP initiative carried out in some developing countries. The SUP's objectives were; i) to raise awareness and compliance in the safe handling and storage of pesticides within the industry, the medical profession and the end-users; ii) to reduce the incidence of pesticide poisoning; iii) to protect the environment; iiii) to help relevant government agencies with resources, expertise and training. To achieve those objectives, the SUP used local-language training resources, provided basic training, lobbied for changes in governmental policies and regulations, and acted as a focal point for pesticide safety-related information. The SUP targeted the whole distribution chain, from importer/formulator, through to the endusers. Also medical profession, teachers and school students were targeted. On the base of independent audit and surveys, a general improvement in awareness has been shown within targeted groups; a longer time frame is required to detect meaningful changes in farmer practice. The SUP key programmes have been: I) training of trainers, retailers and farmers; II) schools programme; III) medical training; IV) protective clothing; V) industry standards; VI) model farm. The main conclusions of the pilot phase were: i) pesticide safety needs to be addressed by all concerned agencies in a joint effort; ii) a rural development perspective must be adopted in improving pesticide safety; iii) integrated pest management training programmes must include precautionary advice for proper handling, use and disposal of pesticides, wherever these are necessary.

Early Rockets

NASA Image and Video Library

1958-01-01

The modified Jupiter C (sometimes called Juno I), used to launch Explorer I, had minimum payload lifting capabilities. Explorer I weighed slightly less than 31 pounds. Juno II was part of America's effort to increase payload lifting capabilities. Among other achievements, the vehicle successfully launched a Pioneer IV satellite on March 3, 1959, and an Explorer VII satellite on October 13, 1959. Responsibility for Juno II passed from the Army to the Marshall Space Flight Center when the Center was activated on July 1, 1960. On November 3, 1960, a Juno II sent Explorer VIII into a 1,000-mile deep orbit within the ionosphere.

The drama of the continuous increase in end-stage renal failure in patients with type II diabetes mellitus.

PubMed

Rychlík, I; Miltenberger-Miltenyi, G; Ritz, E

1998-01-01

Type II diabetes mellitus has become the leading cause of end-stage renal failure in many countries of Western Europe. In all European countries, even in those with a relatively low prevalence of diabetic nephropathy, the number of patients with type II diabetes mellitus admitted for renal replacement therapy has recently increased continuously. Survival and medical rehabilitation of patients with type II diabetes on renal replacement therapy is significantly worse than in non-diabetic patients. It is obvious that in order to stem the tide, intense efforts are necessary (i) to inform the medical community about the renal risk of type II diabetes and the striking effectiveness of preventive measures, (ii) to provide better care for diabetic patients, and (iii) to reduce the high prevalence of diabetes in the population by modification of the Western life style.

Antimicrobial stewardship: a qualitative study of the development of national guidelines for antibiotic use in hospitals.

PubMed

Feiring, Eli; Walter, Anne Berit

2017-11-21

As effective antibiotics are becoming a scarce resource, governmental regulation is needed to promote responsible use. Implementation of antibiotic stewardship and practice guidelines in health care facilities seems to be crucial to this effort. Empirical studies suggest, however, that guidelines have limited influence on health professionals' behavior and practice. Barriers and facilitators to guideline implementability are much studied, but little attention has been given to health professionals' perceptions of normative acceptability of guidelines as a condition for compliance. The aim of the present study was first, to examine if and how aspects potentially promoting acceptability and compliance among clinical target users were addressed during development of Norwegian national guidelines for antibiotic use in hospitals and second, to identify procedural characteristics of the development process that were perceived by target users to yield legitimate guidelines. Qualitative deductive thematic analysis was used. A theoretical framework inspired by the AGREE II Instrument and the Accountability for reasonableness framework assisted data gathering and interpretation. Archival data was collected and used to detail the guideline development process. Semi-structured, in-depth interviews with eight clinicians with extensive knowledge of the guidelines were carried out. Guideline development was characterized by i) broad agreement about scope and purpose, ii) broad involvement of stakeholders in the development process, iii) use of systematic methods to search for and apply evidence, iv) easily identifiable and specific recommendations, v) provision of tools on how to put recommendations into practice, and vi) editorial independence. Several procedural characteristics were perceived by the interviewees as promoting guideline legitimacy; i) diverse perspectives systematically involved in the process, ii) accessibility and transparency of the rationales for decision making, iii) opportunities for appeals and reconsiderations, and iv) regulative authority. This study provides insights as to how guidelines that are intended to promote responsible use of antibiotics in hospitals can be carefully developed to facilitate perceptions of relevance, transparency, and authority by health professionals.

The Role of Proteomics in Biomarker Development for Improved Patient Diagnosis and Clinical Decision Making in Prostate Cancer

PubMed Central

Tonry, Claire L.; Leacy, Emma; Raso, Cinzia; Finn, Stephen P.; Armstrong, John; Pennington, Stephen R.

2016-01-01

Prostate Cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Although increased expression of prostate-specific antigen (PSA) is an effective indicator for the recurrence of PCa, its intended use as a screening marker for PCa is of considerable controversy. Recent research efforts in the field of PCa biomarkers have focused on the identification of tissue and fluid-based biomarkers that would be better able to stratify those individuals diagnosed with PCa who (i) might best receive no treatment (active surveillance of the disease); (ii) would benefit from existing treatments; or (iii) those who are likely to succumb to disease recurrence and/or have aggressive disease. The growing demand for better prostate cancer biomarkers has coincided with the development of improved discovery and evaluation technologies for multiplexed measurement of proteins in bio-fluids and tissues. This review aims to (i) provide an overview of these technologies as well as describe some of the candidate PCa protein biomarkers that have been discovered using them; (ii) address some of the general limitations in the clinical evaluation and validation of protein biomarkers; and (iii) make recommendations for strategies that could be adopted to improve the successful development of protein biomarkers to deliver improvements in personalized PCa patient decision making. PMID:27438858

Concurrent Flow Lanes - Phase II

DOT National Transportation Integrated Search

2009-04-17

This report provides the findings from a research effort designed to ascertain whether or not a chosen simulation software platform, the VISSIM micro-simulation platform, provides a suitable environment for modeling and analyzing traffic operations, ...

HSCT Sector Combustor Evaluations for Demonstration Engine

NASA Technical Reports Server (NTRS)

Greenfield, Stuart; Heberling, Paul; Kastl, John; Matulaitis, John; Huff, Cynthia

2004-01-01

In LET Task 10, critical development issues of the HSCT lean-burn low emissions combustor were addressed with a range of engineering tools. Laser diagnostics and CFD analysis were applied to develop a clearer understanding of the fuel-air premixing process and premixed combustion. Subcomponent tests evaluated the emissions and operability performance of the fuel-air premixers. Sector combustor tests evaluated the performance of the integrated combustor system. A 3-cup sector was designed and procured for laser diagnostics studies at NASA Glenn. The results of these efforts supported the earlier selection of the Cyclone Swirler as the pilot stage premixer and the IMFH (Integrated Mixer Flame Holder) tube as the main stage premixer of the LPP combustor. In the combustor system preliminary design subtask, initial efforts to transform the sector combustor design into a practical subscale engine combustor met with significant challenges. Concerns about the durability of a stepped combustor dome and the need for a removable fuel injection system resulted in the invention and refinement of the MRA (Multistage Radial Axial) combustor system in 1994. The MRA combustor was selected for the HSR Phase II LPP subscale combustor testing in the CPC Program.

The application of SMA spring actuators to a lightweight modular compliant surface bioinspired robot

NASA Astrophysics Data System (ADS)

Stone, David L.; Cranney, John; Liang, Robert; Taya, Minoru

2004-07-01

The DARPA Sponsored Compliant Surface Robotics (CSR) program pursues development of a high mobility, lightweight, modular, morph-able robot for military forces in the field and for other industrial uses. The USTLAB and University of Washington Center for Intelligent Materials and Systems (CIMS) effort builds on USTLAB proof of concept feasibility studies and demonstration of a 4, 6, or 8 wheeled modular vehicle with articulated leg-wheel assemblies. A collaborative effort between USTLAB and UW-CIMS explored the application of Shape Memory Alloy Nickel Titanium Alloy springs to a leg extension actuator capable of actuating with 4.5 Newton force over a 50 mm stroke. At the completion of Phase II, we have completed mechanical and electronics engineering design and achieved conventional actuation which currently enable active articulation, enabling autonomous reconfiguration for a wide variety of terrains, including upside down operations (in case of flip over), have developed a leg extension actuator demonstration model, and we have positioned our team to pursue a small vehicle with leg extension actuators in follow on work. The CSR vehicle's modular spider-like configuration facilitates adaptation to many uses and compliance over rugged terrain. The developmental process, actuator and vehicle characteristics will be discussed.

The future of high-level nuclear waste disposal, state sovereignty and the tenth amendment: Nevada v. Watkins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swazo, S.

The federal government`s monopoly over America`s nuclear energy production began during World War II with the birth of the Atomic Age. During the next thirty years, nuclear waste inventories increased with minor congressional concern. In the early 1970s, the need for federal legislation to address problems surrounding nuclear waste regulation, along with federal efforts to address these problems, became critical. Previous federal efforts had completely failed to address nuclear waste disposal. In 1982, Congress enacted the Nuclear Waste Policy Act (NWPA) to deal with issues of nuclear waste management and disposal, and to set an agenda for the development ofmore » two national high-level nuclear waste repositories. This article discusses the legal challenge to the NWPA in the Nevada v. Watkins case. This case illustrates the federalism problems faced by the federal government in trying to site the nation`s only high-level nuclear waste repository within a single state.« less

The two worlds of race: a historical view.

PubMed

Franklin, John Hope

2011-01-01

Franklin's essay traces the practices, policies, and laws that, from colonial times through the mid-1960s moment when he composed his essay, created and sustained the two worlds of race in America. He outlines the history of efforts from that period to alleviate racial distinctions and to foster a "world of equality and complete human fellowship." Franklin cautions, however, that even certain well-intentioned efforts to extend services, opportunities, and rights to African Americans sometimes reinforced segregation and discrimination. He considers how key historical, legal, political, and social developments from the twentieth century -- World War II, the growth of labor unions, the Great Migration, America's ascendancy as a world power, among others -- advanced racial equality in America while often intensifying the backlash from opponents to such equality. Still, Franklin concludes optimistically that however strident those opponents may be, they "have been significantly weakened by the very force of the numbers and elements now seeking to eliminate the two worlds of race."

Management of Endurance Risk Factors: A Guide for Deep Draft Vessels

DTIC Science & Technology

2001-02-01

Poor diet (frequent fried foods, high fat and sugar content, frequent caffeine consumption) • High workload (high physical and/or mental effort...Appendix A) q 8. Poor diet (menu includes frequent fried foods, high fat and sugar content, frequent caffeine consumption; see Section II-4, and II...into glucose (or sugar ), amino acids, and fatty acids. Cells throughout the body then process these compounds to make energy or ATP

Initial Single Event Effects Testing of the Xilinx Virtex-4 Field Programmable Gate Array

NASA Technical Reports Server (NTRS)

Allen, Gregory R.; Swift, Gary M.; Carmichael, C.; Tseng, C.

2007-01-01

We present initial results for the thin epitaxial Xilinx Virtex-4 Fie ld Programmable Gate Array (FPGA), and compare to previous results ob tained for the Virtex-II and Virtex-II Pro. The data presented was a cquired through a consortium based effort with the common goal of pr oviding the space community with data and mitigation methods for the use of Xilinx FPGAs in space.

A Brief Survey of Democracy Promotion in U.S. Foreign Policy

DTIC Science & Technology

2014-03-01

highlight that economic and security concerns both pre-dated active democracy promotion efforts. 2 For its first centennial , the United States was...the troubles of the world. The 1930s brought the Great Depression and the perception that democracy and capitalism might not be such good ideas after...peacetime foreign policy on democracy was somewhat constrained by the Great Depression and World War II. As World War II raged, FDR eloquently

Progress in the Development of Metamorphic Multi-Junction III-V Space-Solar Cells at Essential Research Incorporated

NASA Technical Reports Server (NTRS)

Sinharoy, Samar; Patton, Martin O.; Valko, Thomas M., Sr.; Weizer, Victor G.

2002-01-01

Theoretical calculations have shown that highest efficiency III-V multi-junction solar cells require alloy structures that cannot be grown on a lattice-matched substrate. Ever since the first demonstration of high efficiency metamorphic single junction 1.1 eV and 1.2 eV InGaAs solar cells by Essential Research Incorporated (ERI), interest has grown in the development of multi-junction cells of this type using graded buffer layer technology. ERI is currently developing a dual-junction 1.6 eV InGaP/1.1 eV InGaAs tandem cell (projected practical air-mass zero (AM0), one-sun efficiency of 28%, and 100-sun efficiency of 37.5%) under a Ballistic Missile Defense Command (BMDO) SBIR Phase II program. A second ongoing research effort at ERI involves the development of a 2.1 eV AlGaInP/1.6 eV InGaAsP/1.2 eV InGaAs triple-junction concentrator tandem cell (projected practical AM0 efficiency of 36.5% under 100 suns) under a SBIR Phase II program funded by the Air Force. We are in the process of optimizing the dual-junction cell performance. In case of the triple-junction cell, we have developed the bottom and the middle cell, and are in the process of developing the layer structures needed for the top cell. A progress report is presented in this paper.

External Payload Carrier (XPC) A Suborbital Research Platform

NASA Technical Reports Server (NTRS)

Schallhorn, Paul; Tatro, Chuck; Kutter, Bernard; Szatkowski, Gerald; Stopnitzky, Ben; Bulk, Tim

2011-01-01

This slide presentation details the concept of an External Payload Carrier (XPC), that can fly on ann unused Solid Rocket Booster (SRB) location on the Atlas V rocket to suborbital environment. The XPC can be used anytime there is sufficient excess lift capability available. The dimensions and possible uses of the XPC are reviewed. The completed Phase 1 study reviewed 57 variations, and arrived at three viable configurations, identified design baselines, subsystems and preliminary testing requirements. Phase II effort is planned to produce the preliminary design (i.e., PDR level), Systems Requirements Document (SRD), identify flight candidates, develop schedule and funding profiles, and identify the risk-reduction activities.

Advancement of Miniature Optic Gas Sensor (MOGS) Probe Technology

NASA Technical Reports Server (NTRS)

Chullen, Cinda

2015-01-01

Advancement of Miniature Optic Gas Sensor (MOGS) Probe Technology" project will investigate newly developed optic gas sensors delivered from a Small Business Innovative Research (SBIR) Phase II effort. A ventilation test rig will be designed and fabricated to test the sensors while integrated with a Suited Manikin Test Apparatus (SMTA). Once the sensors are integrated, a series of test points will be completed to verify that the sensors can withstand Advanced Suit Portable Life Support System (PLSS) environments and associated human metabolic profiles for changes in pressure and levels of Oxygen (ppO2), carbon dioxide (ppCO2), and humidity (ppH2O).

The forgotten French: The 'heroic' era of kidney transplantation.

PubMed

Cooper, David Kc

2017-11-01

The efforts in the late 1940s to 1960s of two Parisian pioneers in kidney transplantation, René Kűss, a surgeon, and Jean Hamburger, a nephrologist, have largely been forgotten. Küss developed the operation that is basically unchanged today. Both groups initiated clinical transplant programs in January 1951, and both were among the first to carry out kidney transplantation (i) without immunosuppressive therapy, (ii) between living-related and unrelated donors, (iii) with organs from deceased donors, (iv) with irradiation and immunosuppressive drugs, and (v) with long-term survival. In the opinion of many, the French did not receive full credit for their work internationally.

Wartime rat control, rodent ecology, and the rise and fall of chemical rodenticides.

PubMed

Keiner, Christine

2005-09-01

The story of how World War II stimulated the development of DDT, and the ensuing postwar dependence on such chemical insecticides, is well known. However, less recognition has been given to the wartime efforts to synthesize new rodenticides to fight rat-borne epidemics. Baltimore, Maryland served as the site for field tests of the powerful new compound alpha naphthyl thiourea (ANTU) from 1942-1946. This experimental campaign sparked debates over the efficacy of controlling rats via chemical warfare instead of environmental sanitation, which led to the ironic conclusion that urban rat control demanded an ecological, rather than technological, approach.

An Overview of Power, Energy Storage, and Conversion Efforts for 2014 SBIR Phases I and II

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2016-01-01

Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for agency projects. NASA's Small Business Innovation Research (SBIR) program focuses on technological innovation by investing in development of innovative concepts and technologies to help NASA mission directorates address critical research needs for Agency programs. This report highlights 15 of the innovative SBIR 2014 Phase I and II projects that focus on one of NASA Glenn Research Center's six core competencies-Power, Energy Storage and Conversion. The technologies cover a wide spectrum of applications such as high-radiation-tolerant ceramic voltage isolators, development of hermetic sealing glasses for solid oxide fuel cells, rechargeable lithium metal cells, high-efficiency direct methane solid oxide fuel cell systems, Li metal protection for high-energy space batteries, isolated bidirectional direct current converters for distributed battery energy applications, and high-efficiency rad-hard ultrathin Si photovoltaic cell technology for space. Each article describes an innovation and technical objective and highlights NASA commercial and industrial applications. This report provides an opportunity for NASA engineers, researchers, and program managers to learn how NASA SBIR technologies could help their programs and projects, and lead to collaborations and partnerships between the small SBIR companies and NASA that would benefit both.

The role of thermodynamics in biochemical engineering

NASA Astrophysics Data System (ADS)

von Stockar, Urs

2013-09-01

This article is an adapted version of the introductory chapter of a book whose publication is imminent. It bears the title "Biothermodynamics - The role of thermodynamics in biochemical engineering." The aim of the paper is to give a very short overview of the state of biothermodynamics in an engineering context as reflected in this book. Seen from this perspective, biothermodynamics may be subdivided according to the scale used to formalize the description of the biological system into three large areas: (i) biomolecular thermodynamics (most fundamental scale), (ii) thermodynamics of metabolism (intermediary scale), and (iii) whole-cell thermodynamics ("black-box" description of living entities). In each of these subareas, the main available theoretical approaches and the current and the potential applications are discussed. Biomolecular thermodynamics (i) is especially well developed and is obviously highly pertinent for the development of downstream processing. Its use ought to be encouraged as much as possible. The subarea of thermodynamics of live cells (iii), although scarcely applied in practice, is also expected to enhance bioprocess research and development, particularly in predicting culture performances, for understanding the driving forces for cellular growth, and in developing, monitoring, and controlling cellular cultures. Finally, there is no question that thermodynamic analysis of cellular metabolism (ii) is a promising tool for systems biology and for many other applications, but quite a large research effort is still needed before it may be put to practical use.

Silicon nitride equation of state

NASA Astrophysics Data System (ADS)

Brown, Robert C.; Swaminathan, Pazhayannur K.

2017-01-01

This report presents the development of a global, multi-phase equation of state (EOS) for the ceramic silicon nitride (Si3N4).1 Structural forms include amorphous silicon nitride normally used as a thin film and three crystalline polymorphs. Crystalline phases include hexagonal α-Si3N4, hexagonal β-Si3N4, and the cubic spinel c-Si3N4. Decomposition at about 1900 °C results in a liquid silicon phase and gas phase products such as molecular nitrogen, atomic nitrogen, and atomic silicon. The silicon nitride EOS was developed using EOSPro which is a new and extended version of the PANDA II code. Both codes are valuable tools and have been used successfully for a variety of material classes. Both PANDA II and EOSPro can generate a tabular EOS that can be used in conjunction with hydrocodes. The paper describes the development efforts for the component solid phases and presents results obtained using the EOSPro phase transition model to investigate the solid-solid phase transitions in relation to the available shock data that have indicated a complex and slow time dependent phase change to the c-Si3N4 phase. Furthermore, the EOSPro mixture model is used to develop a model for the decomposition products; however, the need for a kinetic approach is suggested to combine with the single component solid models to simulate and further investigate the global phase coexistences.

Early investigational tubulin inhibitors as novel cancer therapeutics.

PubMed

Nepali, Kunal; Ojha, Ritu; Lee, Hsueh-Yun; Liou, Jing-Ping

2016-08-01

Microtubules represent one of the most logical and strategic molecular targets amongst the current targets for chemotherapy, alongside DNA. In the past decade, tubulin inhibitors as cancer therapeutics have been an area of focus due to the improved understanding and biological relevance of microtubules in cellular functions. Fueled by the objective of developing novel chemotherapeutics and with the aim of establishing the benefits of tubulin inhibition, several clinical trials have been conducted with others ongoing. At present, the antitubulin development pipeline contains an armful of agents under clinical investigation. This review focuses on novel tubulin inhibitors as cancer therapeutics. The article covers the agents which have completed the phase II studies along with the agents demonstrating promising results in phase I studies. Countless clinical trials evaluating the efficacy, safety and pharmacokinetics of novel tubulin inhibitors highlights the scientific efforts being paid to establish their candidature as cancer therapeutics. Colchicine binding site inhibitors as vascular disrupting agents (VDAs) and new taxanes appear to be the most likely agents for future clinical interest. Numerous agents have demonstrated clinical benefits in terms of efficacy and survival in phase I and II studies. However conclusive benefits can only be ascertained on the basis of phase III studies.

Biology and management of ependymomas

PubMed Central

Wu, Jing; Armstrong, Terri S.; Gilbert, Mark R.

2016-01-01

Ependymomas are rare primary tumors of the central nervous system in children and adults that comprise histologically similar but genetically distinct subgroups. The tumor biology is typically more associated with the site of origin rather than being age-specific. Genetically distinct subgroups have been identified by genomic studies based on locations in classic grade II and III ependymomas. They are supratentorial ependymomas with C11orf95-RELA fusion or YAP1 fusion, infratentorial ependymomas with or without a hypermethylated phenotype (CIMP), and spinal cord ependymomas. Myxopapillary ependymomas and subependymomas have different biology than ependymomas with typical WHO grade II or III histology. Surgery and radiotherapy are the mainstays of treatment, while the role of chemotherapy has not yet been established. An in-depth understanding of tumor biology, developing reliable animal models that accurately reflect tumor molecule features, and high throughput drug screening are essential for developing new therapies. Collaborative efforts between scientists, physicians, and advocacy groups will enhance the translation of laboratory findings into clinical trials. Improvements in disease control underscore the need to incorporate assessment and management of patients' symptoms to ensure that treatment advances translate into improvement in quality of life. PMID:27022130

Benchmark matrix and guide: Part II.

PubMed

1991-01-01

In the last issue of the Journal of Quality Assurance (September/October 1991, Volume 13, Number 5, pp. 14-19), the benchmark matrix developed by Headquarters Air Force Logistics Command was published. Five horizontal levels on the matrix delineate progress in TQM: business as usual, initiation, implementation, expansion, and integration. The six vertical categories that are critical to the success of TQM are leadership, structure, training, recognition, process improvement, and customer focus. In this issue, "Benchmark Matrix and Guide: Part II" will show specifically how to apply the categories of leadership, structure, and training to the benchmark matrix progress levels. At the intersection of each category and level, specific behavior objectives are listed with supporting behaviors and guidelines. Some categories will have objectives that are relatively easy to accomplish, allowing quick progress from one level to the next. Other categories will take considerable time and effort to complete. In the next issue, Part III of this series will focus on recognition, process improvement, and customer focus.

Toward a harmonized approach to animal welfare law in Canada.

PubMed

Fraser, David; Koralesky, Katherine E; Urton, Geoff

2018-03-01

Animal protection law in Canada varies across the country. Federal animal protection law exists in the Criminal Code, in regulations for the transport of animals, and in regulations for humane handling and slaughter at abattoirs that are inspected by the Canadian Food Inspection Agency. Provincial animal protection laws often include provisions that i) describe a duty of care toward animals; ii) prohibit causing or permitting animal "distress;" iii) specify exemptions from prosecution; and iv) reference various national and other standards. Inconsistencies lead to duplication of effort, create difficulty in working across jurisdictions, and may erode public trust. A more consistent approach might be achieved by i) referencing a common suite of standards in provincial statutes; ii) citing the federal transport and humane slaughter regulations in provincial regulations; iii) establishing agreements so provincial authorities may enforce federal regulations; iv) wider and more uniform adoption of enforcement tools that require people to take immediate action to protect animal welfare; v) developing new standards; and vi) national consultation to define frequently used terms.

Human Data Supporting Glyburide in Ischemic Stroke

PubMed Central

Sheth, Kevin N.; Simard, J. Marc; Elm, Jordan; Kronenberg, Golo; Kunte, Hagen; Kimberly, W. Taylor

2016-01-01

The SUR1-TRPM4 channel is a critical determinant of edema and hemorrhagic transformation after focal ischemia. Blockade of this channel by the small molecule glyburide results in improved survival and neurological outcome in multiple preclinical models of ischemic stroke. A robust, compelling body of evidence suggests that an intravenous (IV) formulation of glyburide, RP-1127, can prevent swelling and improve outcome in patients with stroke. Retrospective studies of diabetic stroke patients show improved outcomes in patients who are continued on sulfonylureas after stroke onset. Early phase II study of MRI and plasma biomarkers support the conclusion that RP-1127 may decrease swelling and hemorrhagic transformation. Finally, the ongoing phase II RP-1127 development program has demonstrated continued safety as well as feasibility of enrollment and tolerability of the intervention. Continued efforts to complete the ongoing phase IIb study and definitive efficacy studies are urgently needed to bring a candidate pharmacotherapy to a population of severe stroke patients that currently have no alternative. PMID:26463916

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, Timothy; Smith, Andrew D.; Holder, Gareth M.

The development of more accurate and sensitive diagnostic techniques is a key factor in efforts to improve cancer survival rates. The technique of infrared aperture fibre scanning near-field optical microscopy (IR-SNOM),together with radiation from the infrared free-electron laser (IR-FEL) on ALICEat Daresbury Laboratory (UK), has been used to obtain IR images of a crypt-like feature and the surrounding tissue; the tissue was taken from a patient with oesophageal adenocarcinoma and with a history of Barrett’s oesophagus. We have shown that the DNA signal is enhanced relative to other contributions in the region of the crypt, and the glycoprotein signal showsmore » a less pronounced increase in the region of the crypt. The Amide II signal is found to be anti-correlated with the DNA and glycoprotein profiles. The absorbance of the Amide II signal is found to differ for three different types of cancer tissue. In conclusion, high-resolution IR images of the crypt reveal additional structure that would not be resolved in diffraction-limited techniques.« less

The Pathologist Workforce in the United States: II. An Interactive Modeling Tool for Analyzing Future Qualitative and Quantitative Staffing Demands for Services.

PubMed

Robboy, Stanley J; Gupta, Saurabh; Crawford, James M; Cohen, Michael B; Karcher, Donald S; Leonard, Debra G B; Magnani, Barbarajean; Novis, David A; Prystowsky, Michael B; Powell, Suzanne Z; Gross, David J; Black-Schaffer, W Stephen

2015-11-01

Pathologists are physicians who make diagnoses based on interpretation of tissue and cellular specimens (surgical/cytopathology, molecular/genomic pathology, autopsy), provide medical leadership and consultation for laboratory medicine, and are integral members of their institutions' interdisciplinary patient care teams. To develop a dynamic modeling tool to examine how individual factors and practice variables can forecast demand for pathologist services. Build and test a computer-based software model populated with data from surveys and best estimates about current and new pathologist efforts. Most pathologists' efforts focus on anatomic (52%), laboratory (14%), and other direct services (8%) for individual patients. Population-focused services (12%) (eg, laboratory medical direction) and other professional responsibilities (14%) (eg, teaching, research, and hospital committees) consume the rest of their time. Modeling scenarios were used to assess the need to increase or decrease efforts related globally to the Affordable Care Act, and specifically, to genomic medicine, laboratory consolidation, laboratory medical direction, and new areas where pathologists' expertise can add value. Our modeling tool allows pathologists, educators, and policy experts to assess how various factors may affect demand for pathologists' services. These factors include an aging population, advances in biomedical technology, and changing roles in capitated, value-based, and team-based medical care systems. In the future, pathologists will likely have to assume new roles, develop new expertise, and become more efficient in practicing medicine to accommodate new value-based delivery models.

ARPA-E: Accelerating U.S. Energy Innovation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manser, Joseph S.; Rollin, Joseph A.; Brown, Kristen E.

ARPA-E is charged with addressing the most pressing issues facing the U.S. energy sector today, as well as those projected to impact national energy security in the future. The agency’s mission is clearly elucidated in its authorizing statute:2 “To overcome long-term and high-risk technological barriers in the development of energy technologies.” The three principal thrusts of the agency’s mission are (i) reducing energy imports, (ii) reducing energy-related emissions and greenhouse gases, and (iii) improving energy efficiency in all sectors of the U.S. economy. Meeting these ambitious challenges requires focused, interdisciplinary effort on a national scale that will help ensure themore » United States maintains a competitive lead in developing and deploying advanced energy technologies.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eckert-Gallup, Aubrey Celia; Lewis, John R.; Brooks, Dusty Marie

This report describes the methods, results, and conclusions of the analysis of 11 scenarios defined to exercise various options available in the xLPR (Extremely Low Probability of Rupture) Version 2 .0 code. The scope of the scenario analysis is three - fold: (i) exercise the various options and components comprising xLPR v2.0 and defining each scenario; (ii) develop and exercise methods for analyzing and interpreting xLPR v2.0 outputs ; and (iii) exercise the various sampling options available in xLPR v2.0. The simulation workflow template developed during the course of this effort helps to form a basis for the application ofmore » the xLPR code to problems with similar inputs and probabilistic requirements and address in a systematic manner the three points covered by the scope.« less

From crystal to compound: structure-based antimalarial drug discovery.

PubMed

Drinkwater, Nyssa; McGowan, Sheena

2014-08-01

Despite a century of control and eradication campaigns, malaria remains one of the world's most devastating diseases. Our once-powerful therapeutic weapons are losing the war against the Plasmodium parasite, whose ability to rapidly develop and spread drug resistance hamper past and present malaria-control efforts. Finding new and effective treatments for malaria is now a top global health priority, fuelling an increase in funding and promoting open-source collaborations between researchers and pharmaceutical consortia around the world. The result of this is rapid advances in drug discovery approaches and technologies, with three major methods for antimalarial drug development emerging: (i) chemistry-based, (ii) target-based, and (iii) cell-based. Common to all three of these approaches is the unique ability of structural biology to inform and accelerate drug development. Where possible, SBDD (structure-based drug discovery) is a foundation for antimalarial drug development programmes, and has been invaluable to the development of a number of current pre-clinical and clinical candidates. However, as we expand our understanding of the malarial life cycle and mechanisms of resistance development, SBDD as a field must continue to evolve in order to develop compounds that adhere to the ideal characteristics for novel antimalarial therapeutics and to avoid high attrition rates pre- and post-clinic. In the present review, we aim to examine the contribution that SBDD has made to current antimalarial drug development efforts, covering hit discovery to lead optimization and prevention of parasite resistance. Finally, the potential for structural biology, particularly high-throughput structural genomics programmes, to identify future targets for drug discovery are discussed.

76 FR 69728 - SFIREG Full Committee; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... holidays. The Docket Facility telephone number is (703) 305-5805. II. Tentative Agenda Topics 1. Bed Bug IP... update. 15. Bed bug efforts update. 16. Regional issues. 17. Status of Worker Protection Standard...

Introduction Part II: Formal Dynamics.

ERIC Educational Resources Information Center

Stephens, Suzanne

1979-01-01

In the current period of questioning of architectural values and directions, the implications of energy use on form must be confronted sooner or later. Efforts by various practitioners at combining art and technology are shown. (Author/MLF)

Thruput Analysis of AFLC CYBER 73 Computers.

DTIC Science & Technology

1981-12-01

Ref 2:14). This decision permitted a fast conversion effort with minimum programmer/analyst experience (Ref 34). Recently, as the conversion effort...converted (Ref 1:2). 2 . i i i II I i4 Moreover, many of the large data-file and machine-time- consuming systems were not included in the earlier...by LMT personnel revealed that during certain periods i.e., 0000-0800, the machine is normally reserved for the large 3 4 resource- consuming programs

Summit II: A Call to Action in Support of Black Single Mothers. Proceedings of Thirty-four of Thirty-eight Conferences Sponsored by Delta Sigma Theta Society, Inc.

ERIC Educational Resources Information Center

Delta Sigma Theta Sorority, Inc., Washington, DC.

The proceedings of 34 workshops held to consider ways of solving the problems of black single mothers, held in 1984 in different cities, are collected in this report. All of the workshops were part of Delta Sigma Theta Sorority's pilot program, "Summit II: A Call to Action in Suppprt of Black Single Mothers," an effort to strengthen the…

Model Validation Against The Modelers’ Data Archive

DTIC Science & Technology

2014-08-01

completion of the planned Jack Rabbit 2 field trials. The relevant task for the effort addressed here is Task 4 of the current Interagency Agreement, as...readily simulates the Prairie Grass sulfur dioxide plumes. Also, Jack Rabbit II field trials are set to be completed during FY16. Once these data are...available, they will also be used to validate the combined models. This validation may prove to be more useful, as the Jack Rabbit II will release

The Broken Machine: The US Army Division in the Age of Brigade Modularity

DTIC Science & Technology

2017-05-15

Doctrine, Division Training, General Staff Officer Education , Fires, Field Artillery, World War II 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF...age of Napoleon. This amazing transformation in the interwar period was the result of a focused effort by a cadre of leaders in the US Army to build...Reardon, Victory at Mortain, 265. 6 Peter J. Schifferle, America’s School for War: Fort Leavenworth, Officer Education , and Victory in World War II

How did Japanese rural dwellers become rapidly healthier in the two decades following World War II?: Examining the diverse policy interventions that improved the population's health.

PubMed

Yuasa, Motoyuki

2017-01-01

Objective　During the two decades following Japan's World War II surrender in 1945, tremendous improvement in the population's health was observed, particularly in infant mortality and life expectancy. How did Japanese rural dwellers achieve such remarkable health improvement during this relatively short time span while its economy remained heavily damaged following the war? While the efforts from government-driven public health strategies and programs are well known, relatively little is known about the contributions of policies in non-health sectors. Therefore, the main aim is to verify, using literature based sources, whether non-health sectors contributed to the betterment of the population's health in addition to the public health sector policies.Hypotheses　Synergistic efforts of diverse interventions from different policies and programs likely catalyzed the drastic health improvement observed in the Japanese population in the two decades after World War II. The Ministry of Health and Welfare, for example, implemented programs to provide health care services. These are thought to have contributed directly to reducing maternal and child mortality, as well as tuberculosis-related mortality. Additionally, the Ministry of Agriculture and Forestry carried out a nationwide livelihood improvement program to enhance individual and family lifestyles, improve indoor and outdoor environments, and strengthen social solidarity. The ministry also attempted to generate income stability for farmers through an agricultural improvement program to ensure allocation of household income to family health. The Ministry of Education also had an initiative to disseminate the concepts of democracy and rational thought to the Japanese population through a social education program. Through these efforts, superstition and pre-modern customs were reduced, and subsequently health awareness increased, leading to an improvement in the population's health.Conclusion　The public health policies implemented in Japan as well as the integration of various policies and programs addressing livelihoods, economics, and education greatly improved the population's health in a relatively short time. These non-health initiatives intersected with a wide range of health determinants. Verifying these hypotheses in detail would help develop effective measures for international aid to poverty-stricken regions. It also encourages alternative ways through which Japan could overcome its present-day challenges such as a rapidly aging population with limited access to national schemes for social security.

Belle II silicon vertex detector

NASA Astrophysics Data System (ADS)

Adamczyk, K.; Aihara, H.; Angelini, C.; Aziz, T.; Babu, V.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, Ti.; Baroncelli, To.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bergauer, T.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Casarosa, G.; Ceccanti, M.; Červenkov, D.; Chendvankar, S. R.; Dash, N.; Divekar, S. T.; Doležal, Z.; Dutta, D.; Enami, K.; Forti, F.; Friedl, M.; Hara, K.; Higuchi, T.; Horiguchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C. W.; Kandra, J.; Kang, K. H.; Kato, E.; Kawasaki, T.; Kodyš, P.; Kohriki, T.; Koike, S.; Kolwalkar, M. M.; Kvasnička, P.; Lanceri, L.; Lettenbicher, J.; Maki, M.; Mammini, P.; Mayekar, S. N.; Mohanty, G. B.; Mohanty, S.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Negishi, K.; Nisar, N. K.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Pilo, F.; Profeti, A.; Rashevskaya, I.; Rao, K. K.; Rizzo, G.; Rozanska, M.; Sandilya, S.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Seino, Y.; Shimizu, N.; Stypula, J.; Suzuki, J.; Tanaka, S.; Tanida, K.; Taylor, G. N.; Thalmeier, R.; Thomas, R.; Tsuboyama, T.; Uozumi, S.; Urquijo, P.; Vitale, L.; Volpi, M.; Watanuki, S.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Würkner, B.; Yamamoto, H.; Yin, H.; Yoshinobu, T.; Belle II SVD Collaboration

2016-09-01

The Belle II experiment at the SuperKEKB collider in Japan is designed to indirectly probe new physics using approximately 50 times the data recorded by its predecessor. An accurate determination of the decay-point position of subatomic particles such as beauty and charm hadrons as well as a precise measurement of low-momentum charged particles will play a key role in this pursuit. These will be accomplished by an inner tracking device comprising two layers of pixelated silicon detector and four layers of silicon vertex detector based on double-sided microstrip sensors. We describe herein the design, prototyping and construction efforts of the Belle-II silicon vertex detector.

Mode II Interlaminar Fracture Toughness and Fatigue Characterization of a Graphite Epoxy Composite Material

NASA Technical Reports Server (NTRS)

O'Brien, T. Kevin; Johnston, William M.; Toland, Gregory J.

2010-01-01

Mode II interlaminar fracture toughness and delamination onset and growth characterization data were generated for IM7/8552 graphite epoxy composite materials from two suppliers for use in fracture mechanics analyses. Both the fracture toughness testing and the fatigue testing were conducted using the End-notched Flexure (ENF) test. The ENF test for mode II fracture toughness is currently under review by ASTM as a potential standard test method. This current draft ASTM protocol was used as a guide to conduct the tests on the IM7/8552 material. This report summarizes the test approach, methods, procedures and results of this characterization effort.

Ripeness sensor development. Final report of a Phase 2 study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stroshine, R.

This is a final report for the Phase II study entitled ``Ripeness Sensor Development.`` The overall objective of the study was the development of a prototype device capable of testing whole fruits for sugar content. Although ripeness and sugar content are not synonymous, they are closely related. Furthermore, the consumer`s acceptance of or preference for fruits is strongly influenced by sugar content. Therefore, the device was called a ripeness sensor. The principle behind the measurement is proton magnetic resonance ({sup 1}H-MR). For several decades, chemists, pharmacists and other scientists have been using {sup 1}H-MR to investigate chemical structure and composition.more » More recently, the technique has been used in laboratories of the food industry for quality control. This effort represents one of the first attempts to adapt {sup 1}H-MR to use in a commercial facility. 28 refs., 36 figs., 7 tabs.« less

Quarterly Report: Microchannel-Assisted Nanomaterial Deposition Technology for Photovoltaic Material Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palo, Daniel R.

2011-04-26

Quarterly report to ITP for Nanomanufacturing program. Report covers FY11 Q2. The primary objective of this project is to develop a nanomanufacturing process which will reduce the manufacturing energy, environmental discharge, and production cost associated with current nano-scale thin-film photovoltaic (PV) manufacturing approaches. The secondary objective is to use a derivative of this nanomanufacturing process to enable greener, more efficient manufacturing of higher efficiency quantum dot-based photovoltaic cells now under development. The work is to develop and demonstrate a scalable (pilot) microreactor-assisted nanomaterial processing platform for the production, purification, functionalization, and solution deposition of nanomaterials for photovoltaic applications. The highmore » level task duration is shown. Phase I consists of a pilot platform for Gen II PV films along with parallel efforts aimed at Gen III PV quantum dot materials. Status of each task is described.« less

Implementation of Wireless and Intelligent Sensor Technologies in the Propulsion Test Environment

NASA Technical Reports Server (NTRS)

Solano, Wanda M.; Junell, Justin C.; Shumard, Kenneth

2003-01-01

From the first Saturn V rocket booster (S-II-T) testing in 1966 and the routine Space Shuttle Main Engine (SSME) testing beginning in 1975, to more recent test programs such as the X-33 Aerospike Engine, the Integrated Powerhead Development (IPD) program, and the Hybrid Sounding Rocket (HYSR), Stennis Space Center (SSC) continues to be a premier location for conducting large-scale propulsion testing. Central to each test program is the capability for sensor systems to deliver reliable measurements and high quality data, while also providing a means to monitor the test stand area to the highest degree of safety and sustainability. As part of an on-going effort to enhance the testing capabilities of Stennis Space Center, the Test Technology and Development group is developing and applying a number of wireless and intelligent sensor technologies in ways that are new to the test existing test environment.

Constellation Program (CxP) Crew Exploration Vehicle (CEV) Project Integrated Landing System

NASA Technical Reports Server (NTRS)

Baker, John D.; Yuchnovicz, Daniel E.; Eisenman, David J.; Peer, Scott G.; Fasanella, Edward L.; Lawrence, Charles

2009-01-01

Crew Exploration Vehicle (CEV) Chief Engineer requested a risk comparison of the Integrated Landing System design developed by NASA and the design developed by Contractor- referred to as the LM 604 baseline. Based on the results of this risk comparison, the CEV Chief engineer requested that the NESC evaluate identified risks and develop strategies for their reduction or mitigation. The assessment progressed in two phases. A brief Phase I analysis was performed by the Water versus Land-Landing Team to compare the CEV Integrated Landing System proposed by the Contractor against the NASA TS-LRS001 baseline with respect to risk. A phase II effort examined the areas of critical importance to the overall landing risk, evaluating risk to the crew and to the CEV Crew Module (CM) during a nominal land-landing. The findings of the assessment are contained in this report.

Optical and UV Sensing Sealed Tube Microchannel Plate Imaging Detectors with High Time Resolution

NASA Astrophysics Data System (ADS)

Siegmund, O.; Vallerga, J.; Tremsin, A.; Hull, J.; Elam, J.; Mane, A.

2014-09-01

Microchannel plate (MCP) based imaging, photon time tagging detector sealed tube schemes have a unique set of operational features that enable high time resolution astronomical and remote sensing applications to be addressed. New detectors using the cross strip (XS), cross delay line (XDL), or stripline anode readouts, a wide range of photocathode types, and advanced MCP technologies have been implemented to improve many performance characteristics. A variety of sealed tubes have been developed including 18mm XS readout devices with GaAs and SuperGenII photocathodes, 25mm XDL readout devices with SuperGenII and GaN photocathodes, and 20 x 20 cm sealed tubes with bialkali photocathodes and strip line readout. One key technology that has just become viable is the ability to make MCPs using atomic layer deposition (ALD) techniques. This employs nanofabrication of the active layers of an MCP on a microcapillary array. This technique opens new performance opportunities, including, very large MCP areas (>20cm), very low intrinsic background, lower radiation induced background, much longer overall lifetime and gain stability, and markedly lower outgassing which can improve the sealed tube lifetime and ease of fabrication. The XS readout has been implemented in formats of 22mm, 50mm and 100mm, and uses MCP charge signals detected on two orthogonal layers of conductive fingers to encode event X-Y positions. We have achieved spatial resolution XS detectors better than 25 microns FWHM, with good image linearity while at low gain (<10^6), substantially increasing local counting rate capabilities and the overall tube lifetime. XS tubes with updated electronics can encode event rates of >5 MHz with ~12% dead time and event timing accuracy of ~100ps. XDL sealed tubes in 25mm format demonstrate ~40 micron spatial resolution at up to ~2 MHz event rates, and have been developed with SupergenII visible regime photocathodes. The XDL tubes also achieve ~100 ps time resolution. Most recently ALD MCPs with an opaque GaN photocathode (100-350nm range) on the MCP surface has been demonstrated in a sealed tube configuration. These ALD MCPs show a stable and permanent 10x gain increase during tube processing. Efforts are also underway to establish ALD MCP configurations with large area sealed tubes from 5cm up to 20cm in size. We will discuss these efforts and their performance characteristics. We will discuss how we are applying these detector system developments to a number of applications. This includes ground based instruments for observations of transient and variable astronomical objects, as well as implementation in satellite instruments for earth atmospheric and solar observations. The XS 18mm sealed tube detectors are being implemented for night time remote reconnaissance and biological single-molecule fluorescence lifetime imaging microscopy. Related efforts also include development of large (20cm) sealed tubes for Cherenkov light detection and large area focal plane imagers, and GaN sealed tube devices are candidates for future astronomical space based UV imaging and spectroscopy.

Superpave in-situ stress/strain investigation--phase II : vol. I, summary report.

DOT National Transportation Integrated Search

2009-05-01

The characterization of materials is an intergral part of the overall effort to validate the Superpave system and to calibrate the performance prdeictionmodels for the environmental conditions observed in the Commonwealth of Pennsylvania.

Theme II Joint Work Plan -2017 Collaboration and Knowledge Sharing on Large-scale Demonstration Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Xiaoliang; Stauffer, Philip H.

This effort is designed to expedite learnings from existing and planned large demonstration projects and their associated research through effective knowledge sharing among participants in the US and China.

Rural variable speed limits : phase II.

DOT National Transportation Integrated Search

2012-05-01

The Wyoming Department of Transportation (WYDOT) installed its first variable speed limit (VSL) corridor along : Interstate 80 in the Elk Mountain Corridor in the Spring of 2009 in an effort to improve safety and reduce road closures, : particularly ...

76 FR 29721 - Shasta County Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-23

... Title II of the Act. The meeting is open to the public. The purpose of the June 29th meeting is review..., field trips, monitoring efforts, and accounting. DATES: The meetings will be held Wednesday, June 29...

[Serving the fatherland: the mobilization of Brazilian nurses during World War II].

PubMed

Cytrynowicz, R

2000-01-01

In 1944, 73 women nurses were sent to Italy to serve in World War II as part of the Forca Expedicionaria Brasileira (FEB) and the Brazilian Air Force (FAB). This event is studied in the context of the Vargas policies to mobilize the civilian population and to construct an internal front. The Estado Novo and the war constituted an important period in the affirmation of 'modern' nursing, as it was likewise vital in affirming nursing as a professional model for middle-class women. Nursing allowed the State to shape one of its most persuasive images: that of motherland. This image brought maternal care right to the battle front, helping make the war a collective experience that should bring together all men and women--all Brazilians--regardless of social stratum. The drive to forge a domestic front combined war mobilization efforts with efforts to win the middle classes over to the Estado Novo.

Policy Change and the National Essential Medicines List Development Process in Brazil between 2000 and 2014: Has the Essential Medicine Concept been Abandoned?

PubMed

Osorio-de-Castro, Claudia G S; Azeredo, Thiago B; Pepe, Vera L E; Lopes, Luciane C; Yamauti, Sueli; Godman, Brian; Gustafsson, Lars L

2018-04-01

Brazil has had a National Essential Medicines List (EML) since 1964. From 2000 to 2010, five consecutive evidence-based editions were produced, building on the essential medicine concept. In 2012, the government changed course to establish a new paradigm, introducing adoption of new medicines as the main aim within the recommendation process. The objective of the article was to report efforts to develop Brazil's national EML, policy changes from 2000 to 2014, discussing results, challenges and perspectives. Brazilian EML history and development process were collected from legislation, minutes, reports and legal ordinances, from 2000 to 2014. The Brazilian EML and the WHO Model Lists were compared using the Anatomical Therapeutic Chemical system. Overlap between lists was verified, and linear trends were produced. Type of membership, inclusion criteria, procedures, flow and listed medicines varied greatly between the selection committees acting before and after 2012. Paradigm-changing legislation aiming at linking list compliance to public financing in 2012 produced (i) greater importance given to political and administrative stakeholders, (ii) increasing trends in number of medicines over the years, (iii) decrease in use of WHO Model List as a reference and (iv) substitution of an essential medicines list review and update process by an adoption decision output. Other issues remained unchanged. Insufficient efforts for list implementation, such as lack of physician education, presented consequences to the health system. Substantial efforts were made to produce and update the list from 2000 to 2014. However, continuous and intense health litigation disproves process outcome effectiveness. © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

Biophysics of magnetic orientation: strengthening the interface between theory and experimental design

PubMed Central

Kirschvink, Joseph L.; Winklhofer, Michael; Walker, Michael M.

2010-01-01

The first demonstrations of magnetic effects on the behaviour of migratory birds and homing pigeons in laboratory and field experiments, respectively, provided evidence for the longstanding hypothesis that animals such as birds that migrate and home over long distances would benefit from possession of a magnetic sense. Subsequent identification of at least two plausible biophysical mechanisms for magnetoreception in animals, one based on biogenic magnetite and another on radical-pair biochemical reactions, led to major efforts over recent decades to test predictions of the two models, as well as efforts to understand the ultrastructure and function of the possible magnetoreceptor cells. Unfortunately, progress in understanding the magnetic sense has been challenged by: (i) the availability of a relatively small number of techniques for analysing behavioural responses to magnetic fields by animals; (ii) difficulty in achieving reproducible results using the techniques; and (iii) difficulty in development and implementation of new techniques that might bring greater experimental power. As a consequence, laboratory and field techniques used to study the magnetic sense today remain substantially unchanged, despite the huge developments in technology and instrumentation since the techniques were developed in the 1950s. New methods developed for behavioural study of the magnetic sense over the last 30 years include the use of laboratory conditioning techniques and tracking devices based on transmission of radio signals to and from satellites. Here we consider methodological developments in the study of the magnetic sense and present suggestions for increasing the reproducibility and ease of interpretation of experimental studies. We recommend that future experiments invest more effort in automating control of experiments and data capture, control of stimulation and full blinding of experiments in the rare cases where automation is impossible. We also propose new experiments to confirm whether or not animals can detect magnetic fields using the radical-pair effect together with an alternate hypothesis that may explain the dependence on light of responses by animals to magnetic field stimuli. PMID:20071390

Exploration Laboratory Analysis FY13

NASA Technical Reports Server (NTRS)

Krihak, Michael; Perusek, Gail P.; Fung, Paul P.; Shaw, Tianna, L.

2013-01-01

The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk, which is stated as the Risk of Inability to Adequately Treat an Ill or Injured Crew Member, and ExMC Gap 4.05: Lack of minimally invasive in-flight laboratory capabilities with limited consumables required for diagnosing identified Exploration Medical Conditions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability in future exploration missions. Mission architecture poses constraints on equipment and procedures that will be available to treat evidence-based medical conditions according to the Space Medicine Exploration Medical Conditions List (SMEMCL), and to perform human research studies on the International Space Station (ISS) that are supported by the Human Health and Countermeasures (HHC) element. Since there are significant similarities in the research and medical operational requirements, ELA hardware development has emerged as a joint effort between ExMC and HHC. In 2012, four significant accomplishments were achieved towards the development of exploration laboratory analysis for medical diagnostics. These achievements included (i) the development of high priority analytes for research and medical operations, (ii) the development of Level 1 functional requirements and concept of operations documentation, (iii) the selection and head-to-head competition of in-flight laboratory analysis instrumentation, and (iv) the phase one completion of the Small Business Innovation Research (SBIR) projects under the topic Smart Phone Driven Blood-Based Diagnostics. To utilize resources efficiently, the associated documentation and advanced technologies were integrated into a single ELA plan that encompasses ExMC and HHC development efforts. The requirements and high priority analytes was used in the selection of the four in-flight laboratory analysis performers. Based upon the competition results, a down select process will be performed in the upcoming year. Looking ahead, this unified effort has positioned each element for an in-flight lab analysis demonstration of select diagnostics measurements in the 2015 timeframe.

Models and Measurements Intercomparison 2

NASA Technical Reports Server (NTRS)

Park, Jae H. (Editor); Ko, Malcolm K. W. (Editor); Jackman, Charles H. (Editor); Plumb, R. Alan (Editor); Kaye, Jack A. (Editor); Sage, Karen H. (Editor)

1999-01-01

Models and Measurement Intercomparison II (MM II) summarizes the intercomparison of results from model simulations and observations of stratospheric species. Representatives from twenty-three modeling groups using twenty-nine models participated in these MM II exercises between 1996 and 1999. Twelve of the models were two- dimensional zonal-mean models while seventeen were three-dimensional models. This was an international effort as seven were from outside the United States. Six transport experiments and five chemistry experiments were designed for various models. Models participating in the transport experiments performed simulations of chemically inert tracers providing diagnostics for transport. The chemistry experiments involved simulating the distributions of chemically active trace cases including ozone. The model run conditions for dynamics and chemistry were prescribed in order to minimize the factors that caused differences in the models. The report includes a critical review of the results by the participants and a discussion of the causes of differences between modeled and measured results as well as between results from different models, A sizable effort went into preparation of the database of the observations. This included a new climatology for ozone. The report should help in evaluating the results from various predictive models for assessing humankind perturbations of the stratosphere.

Interprofessional, psycho-social intervention to facilitate resilience and reduce supportive care needs for patients with cancer: Results of a noncomparative, randomized phase II trial.

PubMed

Eicher, Manuela; Ribi, Karin; Senn-Dubey, Catherine; Senn, Stefanie; Ballabeni, Pierluigi; Betticher, Daniel

2018-04-14

We developed 2 intensity levels of a complex intervention for interprofessional supportive care in cancer (IPSC-C) to facilitate resilience and reduce unmet supportive care needs. We aimed to test the feasibility, acceptability, and preliminary effectiveness of both intensity levels in routine practice. In a randomized, noncomparative phase II trial, newly diagnosed patients received either low (LI-IPSC-C) or high (HI-IPSC-C) intensity interventions. Low-intensity-interprofessional supportive care in cancer (LI-IPSC-C) consisted of 3 electronic assessments of resilience, unmet supportive care needs, mood, and coping effort over 16 weeks with an immediate feedback to clinicians including tailored intervention recommendations to facilitate resilience and supportive care. High-intensity-interprofessional supportive care in cancer (HI-IPSC-C) added 5 structured consultations (face-to-face and telephone) provided by specialized nurses. Primary outcome was a change ≥5 in resilience score on the Connor-Davidson Resilience Scale (CD-RISC). Secondary outcomes were unmet supportive care needs, mood, and coping effort. We assessed feasibility by clinician-provided tailored interventions as recommended and acceptability through qualitative interviews with clinicians and patients. In the LI-IPSC-C arm, 11 of 41, in the HI-IPSC-C arm 17 of 43, patients increased resilience scores by ≥5. Relatively more patients decreased unmet needs in HI-IPSC-C arm. Mood, in both arms, and coping effort, in HI-IPSC-C arm, improved meaningfully. Feasibility was limited for the LI-IPSC-C arm, mainly due to lack of time; acceptability was high in both arms. Neither LI-IPSC-C nor HI-IPSC-C interventions reached the desired threshold. HI-IPSC-C showed positive effects on secondary outcomes and was feasible. Resilience as measured by the CD-RISC may not be the optimal outcome measure for this intervention. Copyright © 2018 John Wiley & Sons, Ltd.

Metal-chelate dye-controlled organization of Cd32S14(SPh)40(4-) nanoclusters into three-dimensional molecular and covalent open architecture.

PubMed

Zheng, Nanfeng; Lu, Haiwei; Bu, Xianhui; Feng, Pingyun

2006-04-12

Chalcogenide II-VI nanoclusters are usually prepared as isolated clusters and have defied numerous efforts to join them into covalent open-framework architecture with conventional templating methods such as protonated amines or inorganic cations commonly used to direct the formation of porous frameworks. Herein, we report the first templated synthesis of II-VI covalent superlattices from large II-VI tetrahedral clusters (i.e., [Cd32S14(SPh)38]2-). Our method takes advantage of low charge density of metal-chelate dyes that is a unique match with three-dimensional II-VI semiconductor frameworks in charge density, surface hydrophilicity-hydrophobicity, and spatial organization. In addition, metal-chelate dyes also serve to tune the optical properties of resulting dye semiconductor composite materials.

Small hydroelectric power plant for Aztec, New Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frey, E.W.

1982-05-01

Preliminary engineering results and the outcome of other specific studies associated with the establishment of a hydroelectric power plant at Aztec, New Mexico, are presented, with particular emphasis on estimated costs of construction and long-term operation. Four alternative levels of effort were evaluated. Recommendations, based primarily on cost effectiveness, are presented along with material useful as a basis for a possible follow-on Phase II study. At least three levels of effort appear economically attractive alternatives for the city to pursue.

Adaptation and Study of AIDS Viruses in Animal and Cell Culture Systems

DTIC Science & Technology

1991-06-28

Cancer Res 1985;44,69-120. 23. Armstrong D, and Walzer P: Experimental infections in the nude mouse. In: The Nude Mouse in Experimental and Clinical...3558-3564. 42. Reka S, Borcich A, Cronin W, Kotler DP: Intestinal HIV infection in AIDS and ARC: correlation with tissue content of p24 and...Assistant II (28 Aug 1989-20 Feb 1990) 100% effort Otho (Sonny) Armstrong , B.S., Research Assistant III (16April 1990-6April 1991) 100% effort Ada

Lifetimes and Oscillator Strengths for Ultraviolet Transitions in P II, Cl II and Cl III

NASA Technical Reports Server (NTRS)

Cheng, S.; Federman, S. R.; Schectman, R. M.; Brown, M.; Irving, R. E.; Fritts, M. C.; Gibson, N. D.

2006-01-01

Oscillator strengths for transitions in P II, Cl II and Cl III are derived from lifetimes and branching factions measured with beam-foil techniques. The focus is on the multiplets with a prominent interstellar line at 1153 A in P II which is seen in spectra of hot stars, and the lines at 1071 A in Cl II and 1011 A in Cl III whose lines are seen in spectra of diffuse interstellar clouds and the Io torus acquired with the Far Ultraviolet Spectroscopic Explorer. These data represent the first complete set of experimental f-values for the lines in the multiplets. Our results for P II (lambda)1153 agree well with Curtis semi-empirical predictions, as well as the large scale computations by Hibbert and by Tayal. The data for Cl II (lambda)1071 also agree very well with the most recent theoretical effort and with Morton s newest recommendations. For Cl III, however, our f-values are significantly larger than those given by Morton; instead, they are more consistent with recent large-scale theoretical calculations. Extensive tests provide confirmation that LS coupling rules apply to the transitions for the multiplets in Cl II and Cl III.

KSC SBIR/STTR 2004 Program Year Report

NASA Technical Reports Server (NTRS)

2005-01-01

The Kennedy Space Center Level III SBIR/STTR management staff is under the Technology Transfer Office within the Spaceport Engineering and Technology Directorate. The SBIR and STTR programs provide an opportunity for small high technology companies and research institutions to participate in Government-sponsored research and development (R&D) programs in key technology areas. The SBIR program was established by Congress in 1982 to provide increased opportunities for small businesses to participate in R&D programs, increase employment, and improve U.S. competitiveness. The program's specific objectives are to stimulate U.S. technological innovation, use small businesses to meet Federal research and development needs, increase private sector commercialization of innovations, and foster and encourage participation by socially disadvantaged businesses. Legislation enacted in December 2000 reauthorized the program and strengthened emphasis on pursuing commercial applications of SBIR projects. An SBIR Phase I contract is the opportunity to establish the feasibility and technical merit of a proposed innovation. Selected competitively, the Phase I contract lasts for 6 months and is funded up to $70,000. SBIR Phase II contracts continue the most promising Phase I projects based on scientific! technical merit, expected value to NASA, company capability, and commercial potential. Phase II contracts are usually for a period of 24 months and may not exceed $600,000. NASA usually selects approximately 40 percent of Phase I projects to continue to the Phase II level. Phase III is the process of furthering the development of a product to make it commercially available. The STTR program awards contracts to small business concerns for cooperative R&D with a nonprofit research institution. Research institutions include nonprofit research organizations, Federal laboratories, or universities. The goal of the program established by Congress is to facilitate the transfer of technology developed by a research institution through the entrepreneurship of a small business. The STIR program is smaller in funding than the SBIR program. While the proposal is submitted by the small business concern, at least 30 percent of the funding and work must originate with the research institution. STTR Phase I projects receive up to $100K for a one-year effort, and a Phase II contract receives up to $600K for two years.

Carbon-Phenolic Cages for High-Speed Bearings. Part II - Bearing Evaluation with a Multiply-Alkylated Cyclopentane (MAC) Lubricant

DTIC Science & Technology

2003-01-01

program manager for the overall effort. The carbon -phenolic cages were fabricated under the direction of Mr. Wei Shih of Allcomp Inc ., City of...friction. The early carbon -phenolic cages were hand wrapped by Allcomp . Since that time, Allcomp has added a wrapping machine that uses uniform tension...AFRL-PR-WP-TR-2003-2032 CARBON -PHENOLIC CAGES FOR HIGH-SPEED BEARINGS Part II - Bearing Evaluation with a Multiply- Alkylated Cyclopentane (MAC

“Addition” and “Subtraction”: Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Xin; Giraldes, John; Sprague, Elizabeth R.

2017-02-17

While adding the structural features that are more favored by on-target activity is the more common strategy in selectivity optimization, the opposite strategy of subtracting the structural features that contribute more to off-target activity can also be very effective. Reported here is our successful effort of improving the kinase selectivity of type II maternal embryonic leucine zipper kinase inhibitors by applying these two complementary approaches together, which clearly demonstrates the powerful synergy between them.

MRP (materiel requirements planning) II education: a team-building experience.

PubMed

Iemmolo, G R

1994-05-01

Conestoga Wood Specialties, a leader in the woodworking industry, is constantly striving for continuous improvement in manufacturing and service. Recently, the company embarked on a major MRP II education effort that served as a framework for team building. This team building concept has carried over into other aspects related to the business, such as the formalization of the sales and operations planning meeting. At Conestoga Wood, it is recognized that successful team building is necessary to achieve and maintain world-class performance.

Superpave in-situ stress/strain investigation--phase II : vol. IV, mechanistic analysis and implementation.

DOT National Transportation Integrated Search

2009-05-01

The characterization of materials is an intergral part of the overall effort to validate the Superpave system and to calibrate the performance prdeictionmodels for the environmental conditions observed in the Commonwealth of Pennsylvania.

77 FR 27715 - Proposed Information Collection; Comment Request; International Billfish Angler Survey

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... Conservation Act (MSA). The data are used by scientists and fishery managers to assist with assessing the... effort for recreational billfish fishing in those areas. II. Method of Collection The paper form is sent...

Moisture sensitivity of hot mix asphalt (HMA) mixtures in Nebraska : phase II.

DOT National Transportation Integrated Search

2009-12-01

As a consequential effort to the previous NDOR research project (P564) on moisture damage, this report presents : outcomes from this project incorporated with the previous project. Performance changes and fundamental material : characteristics associ...

77 FR 25195 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

..., (World War II Home Front Efforts in Arkansas, MPS) .5 mi. from jct. of US 67 & Campbell Ln., Campbell... States Second Generation Veterans Hospitals MPS), 5500 Armstrong Rd., Battle Creek, 12000282 MINNESOTA...

National Traffic Speeds Survey II : 2009

DOT National Transportation Integrated Search

2012-07-01

A field survey was conducted during spring and summer 2009 as a longitudinal repetition to a similar effort undertaken : in 2007. The goal was to measure travel speeds and prepare nationally representative speed estimates for all types of : motor veh...

Research and development studies for MHD/coal power flow train components. Part II. Diagnostics and instrumentation MHD channel combutor. Progres report. [Flow calculations for combustors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloom, M.H.; Lederman, S.; Sforza, P.

1980-01-01

This is Part II of the Technical Progress Report on Tasks II-IV of the subject contract. It deals sequentially with Diagnostics and Instrumentation, the MHD Channel and the Combustor. During this period, a significant effort has gone into establishing a schematic design of a laser diagnostic system which can be applied to the flow-train of the MHD system, and to acquiring, assembling and shaking down a laboratory set-up upon which a prototype can be based. With further reference to the MHD Channel, a model analysis has been initiated of the two-dimensional MHD boundary layer between two electrodes in the limitmore » of small magnetic Reynolds numbers with negligible effect of the flow on the applied magnetic field. An objective of this model study is the assessment of variations in initial conditions on the boundary layer behavior. Finally, the problem of combustion modeling has been studied on an initial basis. The open reports on this subject depict a high degree of empiricism, centering attention on global behavior mainly. A quasi-one-dimensional model code has been set-up to check some of the existing estimates. Also a code for equilibrium combustion has been activated.« less

Performance evaluation of the Abbott RealTime HCV Genotype II for hepatitis C virus genotyping.

PubMed

Sohn, Yong-Hak; Ko, Sun-Young; Kim, Myeong Hee; Oh, Heung-Bum

2010-04-01

The Abbott RealTime hepatitis C virus (HCV) Genotype II (Abbott Molecular Inc.) for HCV genotyping, which uses real-time PCR technology, has recently been developed. Accuracy and sensitivity of detection were assessed using the HCV RNA PHW202 performance panel (SeraCare Life Sciences). Consistency with restriction fragment mass polymorphism (RFMP) data, cross-reactivity with other viruses, and the ability to detect minor strains in mixtures of genotypes 1 and 2 were evaluated using clinical samples. All performance panel viruses were correctly genotyped at levels of >500 IU/mL. Results were 100% concordant with RFMP genotypic data (66/66). However, 5% (3/66) of the samples examined displayed probable genotypic cross reactivity. No cross reactivity with other viruses was evident. Minor strains in the mixtures were not effectively distinguished, even at quantities higher than the detection limit. The Abbott RealTime HCV Genotype II assay was very accurate and yielded results consistent with RFMP data. Although the assay has the advantages of automation and short turnaround time, we suggest that further improvements are necessary before it is used routinely in clinical practice. Efforts are needed to decrease cross reactivity among genotypes and to improve the ability to detect minor genotypes in mixed infections.

Description and pilot results from a novel method for evaluating return of incidental findings from next-generation sequencing technologies.

PubMed

Goddard, Katrina A B; Whitlock, Evelyn P; Berg, Jonathan S; Williams, Marc S; Webber, Elizabeth M; Webster, Jennifer A; Lin, Jennifer S; Schrader, Kasmintan A; Campos-Outcalt, Doug; Offit, Kenneth; Feigelson, Heather Spencer; Hollombe, Celine

2013-09-01

The aim of this study was to develop, operationalize, and pilot test a transparent, reproducible, and evidence-informed method to determine when to report incidental findings from next-generation sequencing technologies. Using evidence-based principles, we proposed a three-stage process. Stage I "rules out" incidental findings below a minimal threshold of evidence and is evaluated using inter-rater agreement and comparison with an expert-based approach. Stage II documents criteria for clinical actionability using a standardized approach to allow experts to consistently consider and recommend whether results should be routinely reported (stage III). We used expert opinion to determine the face validity of stages II and III using three case studies. We evaluated the time and effort for stages I and II. For stage I, we assessed 99 conditions and found high inter-rater agreement (89%), and strong agreement with a separate expert-based method. Case studies for familial adenomatous polyposis, hereditary hemochromatosis, and α1-antitrypsin deficiency were all recommended for routine reporting as incidental findings. The method requires <3 days per topic. We establish an operational definition of clinically actionable incidental findings and provide documentation and pilot testing of a feasible method that is scalable to the whole genome.

Priority Actions and Progress to Substantially and Sustainably Reduce the Mortality, Morbidity and Socioeconomic Burden of Tropical Snakebite.

PubMed

Harrison, Robert A; Gutiérrez, José María

2016-11-24

The deliberations and conclusions of a Hinxton Retreat convened in September 2015, entitled "Mechanisms to reverse the public health neglect of snakebite victims" are reported. The participants recommended that the following priority actions be included in strategies to reduce the global impact of snake envenoming: (a) collection of accurate global snakebite incidence, mortality and morbidity data to underpin advocacy efforts and help design public health campaigns; (b) promotion of (i) public education prevention campaigns; (ii) transport systems to improve access to hospitals and (iii) establishment of regional antivenom-efficacy testing facilities to ensure antivenoms' effectiveness and safety; (c) exploration of funding models for investment in the production of antivenoms to address deficiencies in some regions; (d) establishment of (i) programs for training in effective first aid, hospital management and post-treatment care of victims; (ii) a clinical network to generate treatment guidelines and (iii) a clinical trials system to improve the clinical management of snakebite; (e) development of (i) novel treatments of the systemic and local tissue-destructive effects of envenoming and (ii) affordable, simple, point-of-care snakebite diagnostic kits to improve the accuracy and rapidity of treatment; (f) devising and implementation of interventions to help the people and communities affected by physical and psychological sequelae of snakebite.

Extracellular Electron Transfer and Survival Strategies in Acid Mine Drainage Impacted Soils

NASA Astrophysics Data System (ADS)

Gorby, Y. A.; Senko, J.

2011-12-01

Acid mine drainage (AMD) is a prominent and increasing problem in the greater Appalachian region of the United States and throughout the world. Recognition of the importance of extracellular electron transfer (EET) in microbial communities has provided a fertile research environment for multidisciplinary collaborations to emerge and effectively address complex questions with important environmental implications. Our research focuses on the components, strategies and mechanisms of EET in soil systems impacted by AMD and extends to other biogeochemical systems typified by steep redox gradients. Organisms within acid mine drainage use Fe(II) as their primary electron donor and couple Fe(II) oxidation to the reduction of oxygen as the terminal electron acceptor. Biogenic minerals formed by this process completely encase microbes in think deposits that would seem to limit diffusion of both Fe(II) and O2 for access by the organisms. We have developed methods for catalytically removing biogenic minerals revealing microorganisms and a fine network of filamentous extracellular material. Here we present a status report of our efforts to characterize the molecular and electronic properties of these filaments and to address the hypothesis that at least some of these filaments are electrically conductive microbial nanowires that facilitate electron transfer reactions within this complex biogeochemical system.

Early Beam Injection Scheme for the Fermilab Booster: A Path for Intensity Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, C. M.

Over the past decade, Fermilab has focused efforts on the intensity frontier physics and is committed to increase the average beam power delivered to the neutrino and muon programs substantially. Many upgrades to the existing injector accelerators, namely, the current 400 MeV LINAC and the Booster, are in progress under the Proton Improvement Plan (PIP). Proton Improvement Plan-II (PIP-II) proposes to replace the existing 400 MeV LINAC by a new 800 MeV LINAC, as an injector to the Booster which will increase Booster output power by nearly a factor of two from the PIP design value by the end ofmore » its completion. In any case, the Fermilab Booster is going to play a very significant role for nearly next two decades. In this context, I have developed and investigated a new beam injection scheme called "early injection scheme" (EIS) for the Booster with the goal to significantly increase the beam intensity output from the Booster thereby increasing the beam power to the HEP experiments even before PIP-II era. The scheme, if implemented, will also help improve the slip-stacking efficiency in the MI/RR. Here I present results from recent simulations, beam studies, current status and future plans for the new scheme.« less

Big Sky Carbon Sequestration Partnership

DOE Office of Scientific and Technical Information (OSTI.GOV)

Susan M. Capalbo

2005-11-01

The Big Sky Carbon Sequestration Partnership, led by Montana State University, is comprised of research institutions, public entities and private sectors organizations, and the Confederated Salish and Kootenai Tribes and the Nez Perce Tribe. Efforts under this Partnership in Phase I fall into four areas: evaluation of sources and carbon sequestration sinks that will be used to determine the location of pilot demonstrations in Phase II; development of GIS-based reporting framework that links with national networks; designing an integrated suite of monitoring, measuring, and verification technologies and assessment frameworks; and initiating a comprehensive education and outreach program. The groundwork ismore » in place to provide an assessment of storage capabilities for CO2 utilizing the resources found in the Partnership region (both geological and terrestrial sinks), that would complement the ongoing DOE research agenda in Carbon Sequestration. The region has a diverse array of geological formations that could provide storage options for carbon in one or more of its three states. Likewise, initial estimates of terrestrial sinks indicate a vast potential for increasing and maintaining soil C on forested, agricultural, and reclaimed lands. Both options include the potential for offsetting economic benefits to industry and society. Steps have been taken to assure that the GIS-based framework is consistent among types of sinks within the Big Sky Partnership area and with the efforts of other DOE regional partnerships. The Partnership recognizes the critical importance of measurement, monitoring, and verification technologies to support not only carbon trading but all policies and programs that DOE and other agencies may want to pursue in support of GHG mitigation. The efforts in developing and implementing MMV technologies for geological sequestration reflect this concern. Research is also underway to identify and validate best management practices for soil C in the Partnership region, and to design a risk/cost effectiveness framework to make comparative assessments of each viable sink, taking into account economic costs, offsetting benefits, scale of sequestration opportunities, spatial and time dimensions, environmental risks, and long-term viability. Scientifically sound MMV is critical for public acceptance of these technologies. Deliverables for the 7th Quarter reporting period include (1) for the geological efforts: Reports on Technology Needs and Action Plan on the Evaluation of Geological Sinks and Pilot Project Deployment (Deliverables 2 and 3), and Report on the Feasibility of Mineralization Trapping in the Snake River Plain Basin (Deliverable 14); (2) for the terrestrial efforts: Report on the Evaluation of Terrestrial Sinks and a Report of the Best Production Practices for Soil C Sequestration (Deliverables 8 and 15). In addition, the 7th Quarter activities for the Partnership included further development of the proposed activities for the deployment and demonstration phase of the carbon sequestration pilots including geological and terrestrial pilots, expansion of the Partnership to encompass regions and institutions that are complimentary to the steps we have identified, building greater collaborations with industry and stakeholders in the region, contributed to outreach efforts that spanned all partnerships, co-authorship on the Carbon Capture and Separation report, and developed a regional basis to address future energy opportunities in the region. The deliverables and activities are discussed in the following sections and appended to this report. The education and outreach efforts have resulted in a comprehensive plan which serves as a guide for implementing the outreach activities under Phase I. The public website has been expanded and integrated with the GIS carbon atlas. We have made presentations to stakeholders and policy makers including two tribal sequestration workshops, and made connections to other federal and state agencies concerned with GHG emissions, climate change, and efficient and environmentally-friendly energy production. In addition, the Partnership has plans for integration of our outreach efforts with students, especially at the tribal colleges and at the universities involved in our Partnership. This includes collaboration with MSU and with the U.S.-Norway Summer School, extended outreach efforts at LANL and INEEL, and with the student section of the ASME. Finally, the Big Sky Partnership was involved in key meetings and symposium in the 7th quarter including the USDOE Wye Institute Conference on Carbon Sequestration and Capture (April, 2005); the DOE/NETL Fourth Annual Conference on Carbon Capture and Sequestration (May 2005); Coal Power Development Conference (Denver, June 2005) and meetings with our Phase II industry partners and Governor's staff.« less

Validation and verification of the laser range safety tool (LRST)

NASA Astrophysics Data System (ADS)

Kennedy, Paul K.; Keppler, Kenneth S.; Thomas, Robert J.; Polhamus, Garrett D.; Smith, Peter A.; Trevino, Javier O.; Seaman, Daniel V.; Gallaway, Robert A.; Crockett, Gregg A.

2003-06-01

The U.S. Dept. of Defense (DOD) is currently developing and testing a number of High Energy Laser (HEL) weapons systems. DOD range safety officers now face the challenge of designing safe methods of testing HEL's on DOD ranges. In particular, safety officers need to ensure that diffuse and specular reflections from HEL system targets, as well as direct beam paths, are contained within DOD boundaries. If both the laser source and the target are moving, as they are for the Airborne Laser (ABL), a complex series of calculations is required and manual calculations are impractical. Over the past 5 years, the Optical Radiation Branch of the Air Force Research Laboratory (AFRL/HEDO), the ABL System Program Office, Logicon-RDA, and Northrup-Grumman, have worked together to develop a computer model called teh Laser Range Safety Tool (LRST), specifically designed for HEL reflection hazard analyses. The code, which is still under development, is currently tailored to support the ABL program. AFRL/HEDO has led an LRST Validation and Verification (V&V) effort since 1998, in order to determine if code predictions are accurate. This paper summarizes LRST V&V efforts to date including: i) comparison of code results with laboratory measurements of reflected laser energy and with reflection measurements made during actual HEL field tests, and ii) validation of LRST's hazard zone computations.

Towards Increased Engagement of Geoscientists in Global Development Frameworks

NASA Astrophysics Data System (ADS)

Gill, Joel

2016-04-01

Geoscientists have the potential to make a significant contribution to tackling some of the major socio-environmental challenges of today, including extreme poverty, sustainable development, disaster risk reduction and climate change. This presentation explores the importance and social responsibility of geoscientists to engage in such work through understanding and supporting key global development frameworks. During 2015 the international community agreed three important agendas for change. Each framework relates to the intersection of environmental processes with human activities and behaviours, addressing significant challenges affecting society. The frameworks are (i) the UN Global Goals for Sustainable Development, (ii) the Sendai Framework for Disaster Risk Reduction 2015-2030, and (iii) subject to final confirmation at the time of writing, an agreement on climate change at the Paris Conference of the Parties - COP21. The UN Global Goals for Sustainable Development, for example, includes 17 goals aiming to end extreme poverty, fight inequality and ensure environmental sustainability. Specific goals relate to clean water and sanitation, clean and affordable energy, the development of resilient infrastructure, and the need for climate action. Given this context, here (i) a synthesis is presented of the role of geoscience in successfully achieving these major global development frameworks agreed in 2015, (ii) the ethical and social understanding that underpins effective engagement by geoscientists in the science-policy-practice interface is discussed, and (iii) this required ethical understanding is placed into the context of geoscience training and development needs. This approach demonstrates the importance of geoscientists from across all sectors and specialisms, engaging in the implementation, monitoring and evaluation of global development frameworks. It highlights the importance of a greater awareness and consideration of our ethical responsibilities in order to better support efforts to tackle major societal challenges.

Fractography of composite delamination

NASA Technical Reports Server (NTRS)

Bascom, W. D.

1989-01-01

Delamination is a major failure mode of carbon fiber organic matrix composites. It can occur under a variety of loading conditions. Efforts to develop predictive models of the delamination of carbon fiber composites are hampered by a lack of information about the micromechanics of impact damage and delamination growth. Crack formation and propagation in these materials cannot be observed in sufficient detail to determine micro-damage using currently available nondestructive methods such as acoustic backscattering or x ray imaging. Consequently, destructive methods are required. Delamination of composites in Mode I, Mode II and after low energy impact loads were investigated using metallographic techniques of potting the failed specimens, sectioning and examining the cut sections for damage modes.

Behavioral consequences of disasters: a five-stage model of population behavior.

PubMed

Rudenstine, Sasha; Galea, Sandro

2014-12-01

We propose a model of population behavior in the aftermath of disasters. We conducted a qualitative analysis of an empirical dataset of 339 disasters throughout the world spanning from 1950 to 2005. We developed a model of population behavior that is based on 2 fundamental assumptions: (i) behavior is predictable and (ii) population behavior will progress sequentially through 5 stages from the moment the hazard begins until is complete. Understanding the progression of population behavior during a disaster can improve the efficiency and appropriateness of institutional efforts aimed at population preservation after large-scale traumatic events. Additionally, the opportunity for population-level intervention in the aftermath of such events will improve population health.

Advanced Exploration Systems Water Architecture Study Interim Results

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.

2013-01-01

The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems that enable NASA human exploration missions beyond low Earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near-term missions beyond LEO. The secondary objective is to continue to advance mid-readiness-level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near- and long-term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit Environmental Control and Life Support Systems definition. This study is being performed in three phases. Phase I established the scope of the study through definition of the mission requirements and constraints, as well as identifying all possible WRS configurations that meet the mission requirements. Phase II focused on the near-term space exploration objectives by establishing an International Space Station-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long-term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

AES Water Architecture Study Interim Results

NASA Technical Reports Server (NTRS)

Sarguisingh, Miriam J.

2012-01-01

The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems in order to enable NASA human exploration missions beyond low earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near term missions beyond LEO. The secondary objective is to continue to advance mid-readiness level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near and long term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit environmental control and life support systems (ECLSS) definition. This study is being performed in three phases. Phase I of this study established the scope of the study through definition of the mission requirements and constraints, as well as indentifying all possible WRS configurations that meet the mission requirements. Phase II of this study focused on the near term space exploration objectives by establishing an ISS-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

Development and Experimental Validation of Large Eddy Simulation Techniques for the Prediction of Combustion-Dynamic Process in Syngas Combustion: Characterization of Autoignition, Flashback, and Flame-Liftoff at Gas-Turbine Relevant Operating Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ihme, Matthias; Driscoll, James

2015-08-31

The objective of this closely coordinated experimental and computational research effort is the development of simulation techniques for the prediction of combustion processes, relevant to the oxidation of syngas and high hydrogen content (HHC) fuels at gas-turbine relevant operating conditions. Specifically, the research goals are (i) the characterization of the sensitivity of syngas ignition processes to hydrodynamic processes and perturbations in temperature and mixture composition in rapid compression machines and ow-reactors and (ii) to conduct comprehensive experimental investigations in a swirl-stabilized gas turbine (GT) combustor under realistic high-pressure operating conditions in order (iii) to obtain fundamental understanding about mechanisms controllingmore » unstable flame regimes in HHC-combustion.« less

CMC`s research in Europe and the future potential of CMC`s in industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van de Voorde, M.H.; Nedele, M.R.

1996-12-31

CMC`s (Ceramics Matrix Composites) have been developed for high temperature applications in aerospace and military industries. In general, the CMC`s should be capable of outperforming the best available superalloys. Great efforts are being given to pinpoint spin-off technologies i.e. applications in modern fossil fuel power plants, gas turbines, petrochemistry etc. In these applications, the CMC`s have to operate at temperatures up to 1400{degrees}C, in corrosive environments for long durations. These developments will provoke a breakthrough for this new group of CMC-materials. The paper will: (i) give an overview of the CMC`s research in Europe; processing, and characterization of physical, chemicalmore » and engineering properties at high temperatures; (ii) pinpoint the R&D needs to achieve the potential growth; and (iii) review the industrial potentials.« less

Summary of the Second Workshop on Liquid Argon Time Projection Chamber Research and Development in the United States

DOE PAGES

Acciarri, R.; Adamowski, M.; Artrip, D.; ...

2015-07-28

The second workshop to discuss the development of liquid argon time projection chambers (LArTPCs) in the United States was held at Fermilab on July 8-9, 2014. The workshop was organized under the auspices of the Coordinating Panel for Advanced Detectors, a body that was initiated by the American Physical Society Division of Particles and Fields. All presentations at the workshop were made in six topical plenary sessions: i) Argon Purity and Cryogenics, ii) TPC and High Voltage, iii) Electronics, Data Acquisition and Triggering, iv) Scintillation Light Detection, v) Calibration and Test Beams, and vi) Software. This document summarizes the currentmore » efforts in each of these areas. It primarily focuses on the work in the US, but also highlights work done elsewhere in the world.« less

A Research Roadmap for Computation-Based Human Reliability Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boring, Ronald; Mandelli, Diego; Joe, Jeffrey

2015-08-01

The United States (U.S.) Department of Energy (DOE) is sponsoring research through the Light Water Reactor Sustainability (LWRS) program to extend the life of the currently operating fleet of commercial nuclear power plants. The Risk Informed Safety Margin Characterization (RISMC) research pathway within LWRS looks at ways to maintain and improve the safety margins of these plants. The RISMC pathway includes significant developments in the area of thermalhydraulics code modeling and the development of tools to facilitate dynamic probabilistic risk assessment (PRA). PRA is primarily concerned with the risk of hardware systems at the plant; yet, hardware reliability is oftenmore » secondary in overall risk significance to human errors that can trigger or compound undesirable events at the plant. This report highlights ongoing efforts to develop a computation-based approach to human reliability analysis (HRA). This computation-based approach differs from existing static and dynamic HRA approaches in that it: (i) interfaces with a dynamic computation engine that includes a full scope plant model, and (ii) interfaces with a PRA software toolset. The computation-based HRA approach presented in this report is called the Human Unimodels for Nuclear Technology to Enhance Reliability (HUNTER) and incorporates in a hybrid fashion elements of existing HRA methods to interface with new computational tools developed under the RISMC pathway. The goal of this research effort is to model human performance more accurately than existing approaches, thereby minimizing modeling uncertainty found in current plant risk models.« less

Toxic effect of metal cation binary mixtures to the seaweed Gracilaria domingensis (Gracilariales, Rhodophyta).

PubMed

Mendes, Luiz Fernando; Stevani, Cassius Vinicius; Zambotti-Villela, Leonardo; Yokoya, Nair Sumie; Colepicolo, Pio

2014-01-01

The macroalga Gracilaria domingensis is an important resource for the food, pharmaceutical, cosmetic, and biotechnology industries. G. domingensis is at a part of the food web foundation, providing nutrients and microelements to upper levels. As seaweed storage metals in the vacuoles, they are considered the main vectors to magnify these toxic elements. This work describes the evaluation of the toxicity of binary mixtures of available metal cations based on the growth rates of G. domingensis over a 48-h exposure. The interactive effects of each binary mixture were determined using a toxic unit (TU) concept that was the sum of the relative contribution of each toxicant and calculated using the ratio between the toxicant concentration and its endpoint. Mixtures of Cd(II)/Cu(II) and Zn(II)/Ca(II) demonstrated to be additive; Cu(II)/Zn(II), Cu(II)/Mg(II), Cu(II)/Ca(II), Zn(II)/Mg(II), and Ca(II)/Mg(II) mixtures were synergistic, and all interactions studied with Cd(II) were antagonistic. Hypotheses that explain the toxicity of binary mixtures at the molecular level are also suggested. These results represent the first effort to characterize the combined effect of available metal cations, based on the TU concept on seaweed in a total controlled medium. The results presented here are invaluable to the understanding of seaweed metal cation toxicity in the marine environment, the mechanism of toxicity action and how the tolerance of the organism.

Superpave in-situ stress/strain investigation--phase II : vol. III, field data collection and summary.

DOT National Transportation Integrated Search

2009-05-01

The characterization of materials is an intergral part of the overall effort to validate the Superpave system and to calibrate the performance prdeictionmodels for the environmental conditions observed in the Commonwealth of Pennsylvania.

Virgin Islands: Coral Bay Watershed Management (A Former EPA CARE Project)

EPA Pesticide Factsheets

The Coral Bay Watershed Management is a recipient of the Level II CARE cooperative agreement to continue and expand its collective efforts to stop erosion, sediment, and storm-water pollution of Coral Bay, improve solid waste management,

IMPROVED EQUIPMENT CLEANING IN COATED AND LAMINATED SUBSTRATE MANUFACTURING FACILITIES (PHASE II)

EPA Science Inventory

The report discusses EPA efforts to identify, demonstrate, and publish pollution prevention information and opportunities for equipment cleaning for the coated and laminated substrate manufacturing industry. It summarizes initial data collected and summarized during industry obse...

Cement study : phases I, II, and III.

DOT National Transportation Integrated Search

1970-06-01

This report is the result of a three phase research program in which cements and aggregates from various supplier were studied in an effort to evaluate and improve various constitutents in concrete mixes. The major emphasis of this study has been on ...

34 CFR 363.11 - What information and assurances must be included in the State plan supplement?

Code of Federal Regulations, 2010 CFR

2010-07-01

... under § 363.20. (e) Collaboration. Demonstrate evidence of the efforts of the designated State unit to... expectation that sources will become available; (ii) Provides for periodic monitoring to ensure that each...

34 CFR 363.11 - What information and assurances must be included in the State plan supplement?

Code of Federal Regulations, 2011 CFR

2011-07-01

... under § 363.20. (e) Collaboration. Demonstrate evidence of the efforts of the designated State unit to... expectation that sources will become available; (ii) Provides for periodic monitoring to ensure that each...

Phase II (baseline) report for the Greater Yellowstone Regional Traveler and Weather Information System (GYRTWIS)

DOT National Transportation Integrated Search

2002-09-11

In an effort to make road and weather information more readily available to travelers and maintenance personnel, Montana is implementing the Greater Yellowstone Regional Traveler and Weather Information System (GYRTWIS). GYRTWIS replaces the existing...

48 CFR 1352.216-71 - Level of effort (cost-plus-fixed-fee, term contract).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Optionperiod II Optionperiod III xxxxxxxxxx xxxx xxxx xxxx xxxx xxxxxxxxxx xxxx xxxx xxxx xxxx Total Direct Labor xxxx xxxx xxxx xxxx (c) The hours specified above are provided as estimates only. If the actual...

Evaluating Democracy

ERIC Educational Resources Information Center

Dorn, Charles

2005-01-01

Following World War II, a group of American educators was assigned the task of evaluating the U.S. military government's program for reconstructing Germany's educational system. Although issuing a generally positive report, this education mission identified a number of persistent tensions that ultimately undermined America's efforts to…

Conservation of the 2-keto-3-deoxymanno-octulosonic acid (Kdo) biosynthesis pathway between plants and bacteria.

PubMed

Smyth, Kevin M; Marchant, Alan

2013-10-18

The increasing prevalence of multi-drug resistant bacteria is driving efforts in the development of new antibacterial agents. This includes a resurgence of interest in the Gram-negative bacteria lipopolysaccharide (LPS) biosynthesis enzymes as drug targets. The six carbon acidic sugar 2-keto-3-deoxymanno-octulosonic acid (Kdo) is a component of the lipid A moiety of the LPS in Gram-negative bacteria. In most cases the lipid A substituted by Kdo is the minimum requirement for cell growth, thus presenting the possibility of targeting either the synthesis or incorporation of Kdo for the development of antibacterial agents. Indeed, potent in vitro inhibitors of Kdo biosynthesis enzymes have been reported but have so far failed to show sufficient in vivo action against Gram-negative bacteria. As part of an effort to design more potent antibacterial agents targeting Kdo biosynthesis, the crystal structures of the key Kdo biosynthesis enzymes from Escherichia coli have been solved and their structure based mechanisms characterized. In eukaryotes, Kdo is found as a component of the pectic polysaccharide rhamnogalacturonan II in the plant primary cell wall. Interestingly, despite incorporating Kdo into very different macromolecules the Kdo biosynthesis and activation pathway is almost completely conserved between plants and bacteria. This raises the possibility for plant research to exploit the increasingly detailed knowledge and resources being generated by the microbiology community. Likewise, insights into Kdo biosynthesis in plants will be potentially useful in efforts to produce new antimicrobial compounds. Copyright © 2013 Elsevier Ltd. All rights reserved.

[Science, charity, and social networks: Hospício de Pedro II from different perspectives].

PubMed

Ribeiro, Daniele Corrêa

2016-01-01

This article is part of an effort to compile the analyses made for my master's dissertation from 2012. It contains new perspectives on Hospício de Pedro II (Pedro II Hospice) between 1883 and 1889, drawing on research of admissions records and files of patients staying at the institution, founded in 1852 in Rio de Janeiro. The involvement of different players and the interplay of different interests and demands with regard to the hospice are highlighted. It is important to expand the debate concerning the institution beyond medical and scientific aspects, considering its importance both as a charity and for its key role in the political and social relations of the empire.

System for Anomaly and Failure Detection (SAFD) system development

NASA Technical Reports Server (NTRS)

Oreilly, D.

1992-01-01

This task specified developing the hardware and software necessary to implement the System for Anomaly and Failure Detection (SAFD) algorithm, developed under Technology Test Bed (TTB) Task 21, on the TTB engine stand. This effort involved building two units; one unit to be installed in the Block II Space Shuttle Main Engine (SSME) Hardware Simulation Lab (HSL) at Marshall Space Flight Center (MSFC), and one unit to be installed at the TTB engine stand. Rocketdyne personnel from the HSL performed the task. The SAFD algorithm was developed as an improvement over the current redline system used in the Space Shuttle Main Engine Controller (SSMEC). Simulation tests and execution against previous hot fire tests demonstrated that the SAFD algorithm can detect engine failure as much as tens of seconds before the redline system recognized the failure. Although the current algorithm only operates during steady state conditions (engine not throttling), work is underway to expand the algorithm to work during transient condition.

The marine alga Gelidium amansii promotes the development and complexity of neuronal cytoarchitecture.

PubMed

Hannan, Abdul; Kang, Ji-Young; Hong, Yong-Ki; Lee, Hyunsook; Choi, Jae-Suk; Choi, In Soon; Moon, Il Soo

2013-01-01

Neurotrophic factors are vital not only to support neuronal development but also to protect mature neurons from atrophy in neurodegenerative diseases. As an effort to explore natural sources that possess neurotrophic activity, we screened common marine algae for their neuritogenic activity in the developing rat hippocampal neurons in culture. Of the 22 seaweed species examined, ethanol extracts of Gelidium amansii (GAE) exhibited potent neuritogenic activity, followed by Undaria pinnatifida and Sargassum fulvellum extracts. The effects of GAE were dose dependent with an optimum concentration of 15 µg/mL. The GAE significantly promoted the initial neuronal differentiation from the stage I into the stage II and increased the indices of axonal and dendritic development such as the length, the numbers of primary processes, and branching frequencies by a minimum of twofold compared with the vehicle control. These results show that marine algae are promising candidates for neurotrophic potentials. Copyright © 2012 John Wiley & Sons, Ltd.

Software Framework for Advanced Power Plant Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

John Widmann; Sorin Munteanu; Aseem Jain

2010-08-01

This report summarizes the work accomplished during the Phase II development effort of the Advanced Process Engineering Co-Simulator (APECS). The objective of the project is to develop the tools to efficiently combine high-fidelity computational fluid dynamics (CFD) models with process modeling software. During the course of the project, a robust integration controller was developed that can be used in any CAPE-OPEN compliant process modeling environment. The controller mediates the exchange of information between the process modeling software and the CFD software. Several approaches to reducing the time disparity between CFD simulations and process modeling have been investigated and implemented. Thesemore » include enabling the CFD models to be run on a remote cluster and enabling multiple CFD models to be run simultaneously. Furthermore, computationally fast reduced-order models (ROMs) have been developed that can be 'trained' using the results from CFD simulations and then used directly within flowsheets. Unit operation models (both CFD and ROMs) can be uploaded to a model database and shared between multiple users.« less

Angiotensin II enhances norepinephrine spillover during sympathetic activation in conscious rabbits.

PubMed

Noshiro, T; Shimizu, K; Way, D; Miura, Y; McGrath, B P

1994-05-01

To investigate the potential modulating influence of angiotensin II (ANG II) on sympathetic activity in response to changes in baroreflex activity, renal and total norepinephrine (NE) spillover rates were examined during sodium nitroprusside (SNP) and phenylephrine (PE) infusions in four groups of conscious rabbits: 1) saline (control); 2) subpressor ANG II (ANG II, 2 ng.kg-1.min-1); 3) enalaprilat (MK-422, 200 micrograms/kg and 3.3 micrograms.kg-1.min-1); and 4) MK plus ANG II (MK+ANG II). Upper plateaus of baroreflex-NE spillover curves for renal and total NE spillover were reduced in the MK group (25 and 81 ng/min) compared with control (38 and 125 ng/min) and MK+ANG II (37 and 155 ng/min). To investigate the interaction of ANG II and sympathetic activity during treadmill exercise, hindlimb NE spillover rate was examined in three groups of rabbits: 1) control, 2) MK, and 3) MK+ANG II. Exercise at 6 and 12 m/min produced similar effort-related hemodynamic responses in the three groups. At maximal exercise, hindlimb NE spillover was reduced in the MK group (29 +/- 3 ng/min) compared with control (62 +/- 17 ng/min, P < 0.05) and MK+ANG II group (51 +/- 10 ng/min). It is concluded that endogenous ANG II enhances sympathetic activity during pharmacological (baroreflex) and physiological stimulation.

NetMHCIIpan-2.0 - Improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure.

PubMed

Nielsen, Morten; Justesen, Sune; Lund, Ole; Lundegaard, Claus; Buus, Søren

2010-11-13

Binding of peptides to Major Histocompatibility class II (MHC-II) molecules play a central role in governing responses of the adaptive immune system. MHC-II molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Predicting which peptides bind to an MHC-II molecule is therefore of pivotal importance for understanding the immune response and its effect on host-pathogen interactions. The experimental cost associated with characterizing the binding motif of an MHC-II molecule is significant and large efforts have therefore been placed in developing accurate computer methods capable of predicting this binding event. Prediction of peptide binding to MHC-II is complicated by the open binding cleft of the MHC-II molecule, allowing binding of peptides extending out of the binding groove. Moreover, the genes encoding the MHC molecules are immensely diverse leading to a large set of different MHC molecules each potentially binding a unique set of peptides. Characterizing each MHC-II molecule using peptide-screening binding assays is hence not a viable option. Here, we present an MHC-II binding prediction algorithm aiming at dealing with these challenges. The method is a pan-specific version of the earlier published allele-specific NN-align algorithm and does not require any pre-alignment of the input data. This allows the method to benefit also from information from alleles covered by limited binding data. The method is evaluated on a large and diverse set of benchmark data, and is shown to significantly out-perform state-of-the-art MHC-II prediction methods. In particular, the method is found to boost the performance for alleles characterized by limited binding data where conventional allele-specific methods tend to achieve poor prediction accuracy. The method thus shows great potential for efficient boosting the accuracy of MHC-II binding prediction, as accurate predictions can be obtained for novel alleles at highly reduced experimental costs. Pan-specific binding predictions can be obtained for all alleles with know protein sequence and the method can benefit by including data in the training from alleles even where only few binders are known. The method and benchmark data are available at http://www.cbs.dtu.dk/services/NetMHCIIpan-2.0.

Efforts to Overcome Difficulties in a Higher Education Meteorology Department Institution

NASA Astrophysics Data System (ADS)

Mota, G. V.; Souza, J. R.; Ribeiro, J. B.; Souza, E. B.; Gomes, N. V.; Oliveira, R. A.; Ameida, W. G.; Chagas, G. O.; Yoksas, T.; Spangler, T.; Cutrim, E.

2007-05-01

The development of cyberinfrastructure in higher education meteorology departments has become a key requirement to better qualify their students and develop scientific research. The authors present their efforts to overcome low budget, lack of personnel, and other difficulties in the Department of Meteorology, Universidade Federal do Pará (UFPA), to participate in international collaborations for sharing hydro-meteorological data, tools and technological systems. Some important steps towards a consolidated integration of the group with the international partnership are discussed, and three are highlighted: (a) the resources from the Unidata's Equipment Award (supported by the National Science Foundation - NSF) and equipment donated in cooperation with the COMET and Meteoforum projects; (b) the interaction of the local team making its project resources available to the community; and (c) the involvement of students with the programs and the cyberinfrastructure available locally. Some positive results can be observed, such as the ability for students of Synoptic Meteorology II class to not only see static meteorological fields on the web, but actually build themselves regional and real-time synoptic products from the data received through Unidata's Internet Data Distribution (IDD) system. Moreover, the UFPA's group intends to improve its infrastructure to expand the access of real-time data and products to other members of the local meteorological community.

MIPS: analysis and annotation of proteins from whole genomes in 2005

PubMed Central

Mewes, H. W.; Frishman, D.; Mayer, K. F. X.; Münsterkötter, M.; Noubibou, O.; Pagel, P.; Rattei, T.; Oesterheld, M.; Ruepp, A.; Stümpflen, V.

2006-01-01

The Munich Information Center for Protein Sequences (MIPS at the GSF), Neuherberg, Germany, provides resources related to genome information. Manually curated databases for several reference organisms are maintained. Several of these databases are described elsewhere in this and other recent NAR database issues. In a complementary effort, a comprehensive set of >400 genomes automatically annotated with the PEDANT system are maintained. The main goal of our current work on creating and maintaining genome databases is to extend gene centered information to information on interactions within a generic comprehensive framework. We have concentrated our efforts along three lines (i) the development of suitable comprehensive data structures and database technology, communication and query tools to include a wide range of different types of information enabling the representation of complex information such as functional modules or networks Genome Research Environment System, (ii) the development of databases covering computable information such as the basic evolutionary relations among all genes, namely SIMAP, the sequence similarity matrix and the CABiNet network analysis framework and (iii) the compilation and manual annotation of information related to interactions such as protein–protein interactions or other types of relations (e.g. MPCDB, MPPI, CYGD). All databases described and the detailed descriptions of our projects can be accessed through the MIPS WWW server (). PMID:16381839

MIPS: analysis and annotation of proteins from whole genomes in 2005.

PubMed

Mewes, H W; Frishman, D; Mayer, K F X; Münsterkötter, M; Noubibou, O; Pagel, P; Rattei, T; Oesterheld, M; Ruepp, A; Stümpflen, V

2006-01-01

The Munich Information Center for Protein Sequences (MIPS at the GSF), Neuherberg, Germany, provides resources related to genome information. Manually curated databases for several reference organisms are maintained. Several of these databases are described elsewhere in this and other recent NAR database issues. In a complementary effort, a comprehensive set of >400 genomes automatically annotated with the PEDANT system are maintained. The main goal of our current work on creating and maintaining genome databases is to extend gene centered information to information on interactions within a generic comprehensive framework. We have concentrated our efforts along three lines (i) the development of suitable comprehensive data structures and database technology, communication and query tools to include a wide range of different types of information enabling the representation of complex information such as functional modules or networks Genome Research Environment System, (ii) the development of databases covering computable information such as the basic evolutionary relations among all genes, namely SIMAP, the sequence similarity matrix and the CABiNet network analysis framework and (iii) the compilation and manual annotation of information related to interactions such as protein-protein interactions or other types of relations (e.g. MPCDB, MPPI, CYGD). All databases described and the detailed descriptions of our projects can be accessed through the MIPS WWW server (http://mips.gsf.de).

Internet Gaming Disorder as a formative construct: Implications for conceptualization and measurement.

PubMed

van Rooij, Antonius J; Van Looy, Jan; Billieux, Joël

2017-07-01

Some people have serious problems controlling their Internet and video game use. The DSM-5 now includes a proposal for 'Internet Gaming Disorder' (IGD) as a condition in need of further study. Various studies aim to validate the proposed diagnostic criteria for IGD and multiple new scales have been introduced that cover the suggested criteria. Using a structured approach, we demonstrate that IGD might be better interpreted as a formative construct, as opposed to the current practice of conceptualizing it as a reflective construct. Incorrectly approaching a formative construct as a reflective one causes serious problems in scale development, including: (i) incorrect reliance on item-to-total scale correlation to exclude items and incorrectly relying on indices of inter-item reliability that do not fit the measurement model (e.g., Cronbach's α); (ii) incorrect interpretation of composite or mean scores that assume all items are equal in contributing value to a sum score; and (iii) biased estimation of model parameters in statistical models. We show that these issues are impacting current validation efforts through two recent examples. A reinterpretation of IGD as a formative construct has broad consequences for current validation efforts and provides opportunities to reanalyze existing data. We discuss three broad implications for current research: (i) composite latent constructs should be defined and used in models; (ii) item exclusion and selection should not rely on item-to-total scale correlations; and (iii) existing definitions of IGD should be enriched further. © 2016 The Authors. Psychiatry and Clinical Neurosciences © 2016 Japanese Society of Psychiatry and Neurology.

A European approach to categorizing medicines for fitness to drive: outcomes of the DRUID project

PubMed Central

Ravera, Silvia; Monteiro, Susana P; de Gier, Johan Jacob; van der Linden, Trudy; Gómez-Talegón, Trinidad; Álvarez, F Javier

2012-01-01

AIMS To illustrate (i) the criteria and the development of the DRUID categorization system, (ii) the number of medicines that have currently been categorized, (iii) the added value of the DRUID categorization system and (iv) the next steps in the implementation of the DRUID system. METHODS The development of the DRUID categorization system was based on several criteria. The following steps were considered: (i) conditions of use of the medicine, (ii) pharmacodynamic and pharmacokinetic data, (iii) pharmacovigilance data, including prevalence of undesirable effects, (iv) experimental and epidemiological data, (v) additional data derived from the patient information leaflet, existing categorization systems and (vi) final categorization. DRUID proposed four tiered categories for medicines and driving. RESULTS In total, 3054 medicines were reviewed and over 1541 medicines were categorized (the rest were no longer on the EU market). Nearly half of the 1541 medicines were categorized 0 (no or negligible influence on fitness to drive), about 26% were placed in category I (minor influence on fitness to drive) and 17% were categorized as II or III (moderate or severe influence on fitness to drive). CONCLUSIONS The current DRUID categorization system established and defined standardized and harmonized criteria to categorize commonly used medications, based on their influence on fitness to drive. Further efforts are needed to implement the DRUID categorization system at a European level and further activities should be undertaken in order to reinforce the awareness of health care professionals and patients on the effects of medicines on fitness to drive. PMID:22452358

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, A.; Barnard, J.J.; Briggs, R.J.

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaborationof LBNL, LLNL, and PPPL, has achieved 60-fold pulse compression of ion beams on the Neutralized Drift Compression eXperiment (NDCX) at LBNL. In NDCX, a ramped voltage pulse from an induction cell imparts a velocity"tilt" to the beam; the beam's tail then catches up with its head in a plasma environment that provides neutralization. The HIFS-VNL's mission is to carry out studies of Warm Dense Matter (WDM) physics using ion beams as the energy source; an emerging thrust is basic target physics for heavy ion-driven Inertial Fusion Energy (IFE). Thesemore » goals require an improved platform, labeled NDCX-II. Development of NDCX-II at modest cost was recently enabled by the availability of induction cells and associated hardware from the decommissioned Advanced Test Accelerator (ATA) facility at LLNL. Our initial physics design concept accelerates a ~;;30 nC pulse of Li+ ions to ~;;3 MeV, then compresses it to ~;;1 ns while focusing it onto a mm-scale spot. It uses the ATA cells themselves (with waveforms shaped by passive circuits) to impart the final velocity tilt; smart pulsers provide small corrections. The ATA accelerated electrons; acceleration of non-relativistic ions involves more complex beam dynamics both transversely and longitudinally. We are using analysis, an interactive one-dimensional kinetic simulation model, and multidimensional Warp-code simulations to develop the NDCX-II accelerator section. Both LSP and Warp codes are being applied to the beam dynamics in the neutralized drift and final focus regions, and the plasma injection process. The status of this effort is described.« less

Lessons from half a century experience of Japanese solid rocketry since Pencil rocket

NASA Astrophysics Data System (ADS)

Matogawa, Yasunori

2007-12-01

50 years have passed since a tiny rocket "Pencil" was launched horizontally at Kokubunji near Tokyo in 1955. Though there existed high level of rocket technology in Japan before the end of the second World War, it was not succeeded by the country after the War. Pencil therefore was the substantial start of Japanese rocketry that opened the way to the present stage. In the meantime, a rocket group of the University of Tokyo contributed to the International Geophysical Year in 1957-1958 by developing bigger rockets, and in 1970, the group succeeded in injecting first Japanese satellite OHSUMI into earth orbit. It was just before the launch of OHSUMI that Japan had built up the double feature system of science and applications in space efforts. The former has been pursued by ISAS (the Institute of Space and Astronautical Science) of the University of Tokyo, and the latter by NASDA (National Space Development Agency). This unique system worked quite efficiently because space activities in scientific and applicational areas could develop rather independently without affecting each other. Thus Japan's space science ran up rapidly to the international stage under the support of solid propellant rocket technology, and, after a 20 year technological introduction period from the US, a big liquid propellant launch vehicle, H-II, at last was developed on the basis of Japan's own technology in the early 1990's. On October 1, 2003, as a part of Governmental Reform, three Japanese space agencies were consolidated into a single agency, JAXA (Japan Aerospace Exploration Agency), and Japan's space efforts began to walk toward the future in a globally coordinated fashion, including aeronautics, astronautics, space science, satellite technology, etc., at the same time. This paper surveys the history of Japanese rocketry briefly, and draws out the lessons from it to make a new history of Japan's space efforts more meaningful.

Next decade in infrared detectors

NASA Astrophysics Data System (ADS)

Rogalski, A.

2017-10-01

Fundamental and technological issues associated with the development and exploitation of the most advanced infrared technologies is discussed. In these classes of detectors both photon and thermal detectors are considered. Special attention is directed to HgCdTe ternary alloys, type II superlattices (T2SLs), barrier detectors, quantum wells, extrinsic detectors, and uncooled thermal bolometers. The sophisticated physics associated with the antimonide-based bandgap engineering will give a new impact and interest in development of infrared detector structures. Important advantage of T2SLs is the high quality, high uniformity and stable nature of the material. In general, III-V semiconductors are more robust than their II-VI counterparts due to stronger, less ionic chemical bonding. As a result, III-V-based FPAs excel in operability, spatial uniformity, temporal stability, scalability, producibility, and affordability - the so-called "ibility" advantages. In well established uncooled imaging, microbolometer arrays are clearly the most used technology. The microbolometer detectors are now produced in larger volumes than all other IR array technologies together. Present state-of-the-art microbolometers are based on polycrystalline or amorphous materials, typically vanadium oxide (VOx) or amorphous silicon (a-Si), with only modest temperature sensitivity and noise properties. Basic efforts today are mainly focused on pixel reduction and performance enhancement.

Recovery of Navy distillate fuel from reclaimed product. Volume II. Literature review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brinkman, D.W.; Whisman, M.L.

In an effort to assist the Navy to better utilize its waste hydrocarbons, NIPER, with support from the US Department of Energy, is conducting research designed to ultimately develop a practical technique for converting Reclaimed Product (RP) into specification Naval Distillate Fuel (F-76). This first phase of the project was focused on reviewing the literature and available information from equipment manufacturers. The literature survey has been carefully culled for methodology applicable to the conversion of RP into diesel fuel suitable for Navy use. Based upon the results of this study, a second phase has been developed and outlined in whichmore » experiments will be performed to determine the most practical recycling technologies. It is realized that the final selection of one particular technology may be site-specific due to vast differences in RP volume and available facilities. A final phase, if funded, would involve full-scale testing of one of the recommended techniques at a refueling depot. The Phase I investigations are published in two volumes. Volume 1, Technical Discussion, includes the narrative and Appendices I and II. Appendix III, a detailed Literature Review, includes both a narrative portion and an annotated bibliography containing about 800 references and abstracts. This appendix, because of its volume, has been published separately as Volume 2.« less

Development and testing of nurses' perceptions of the use of hydrotherapy in labor questionnaire.

PubMed

Stark, Mary Ann; Miller, Michael G

2010-01-01

While effective for labor pain, hydrotherapy is not often used. The purpose of this study was to develop and test an instrument of nurses' perceptions of the barriers to the use of hydrotherapy in labor. Following generation of items and review by content experts, the Nurses' Perceptions of the Use of Hydrotherapy in Labor (NPUHL) questionnaire was administered to 65 intrapartum nurses (phase I) and to 401 nurses (phase II). In phase I, the mean score of the NPUHL was significantly and negatively correlated with the Labor Support Scale (r = -.30, p = .016), indicating that nurses who demonstrated more labor-supportive behaviors also perceived fewer barriers to the use of hydrotherapy in labor. In phase II, exploratory factor analysis revealed five factors: Health Care Environment, Knowledge and Beliefs, Personal Concerns, Effort Required for Hydrotherapy, and Technology. There was a significant negative correlation (r = -.61) between use of hydrotherapy and the total NPUHL score and those of its subscales (r = -.12 to -.61); nurses with access to hydrotherapy tubs perceived fewer barriers to hydrotherapy than nurses without (t = 9.71, df= 387, p < .01). For the revised 30-item NPUHL, Cronbach's alpha was .93, and subscale alphas ranged from .58 to .93. The 30-item NPUHL scale demonstrated evidence of good initial reliability and validity.

LWR pressure vessel surveillance dosimetry improvement program: LWR power reactor surveillance physics-dosimetry data base compendium

DOE Office of Scientific and Technical Information (OSTI.GOV)

McElroy, W.N.

1985-08-01

This NRC physics-dosimetry compendium is a collation of information and data developed from available research and commercial light water reactor vessel surveillance program (RVSP) documents and related surveillance capsule reports. The data represents the results of the HEDL least-squares FERRET-SAND II Code re-evaluation of exposure units and values for 47 PWR and BWR surveillance capsules for W, B and W, CE, and GE power plants. Using a consistent set of auxiliary data and dosimetry-adjusted reactor physics results, the revised fluence values for E > 1 MeV averaged 25% higher than the originally reported values. The range of fluence values (new/old)more » was from a low of 0.80 to a high of 2.38. These HEDL-derived FERRET-SAND II exposure parameter values are being used for NRC-supported HEDL and other PWR and BWR trend curve data development and testing studies. These studies are providing results to support Revision 2 of Regulatory Guide 1.99. As stated by Randall (Ra84), the Guide is being updated to reflect recent studies of the physical basis for neutron radiation damage and efforts to correlate damage to chemical composition and fluence.« less

Rotorcraft Optimization Tools: Incorporating Rotorcraft Design Codes into Multi-Disciplinary Design, Analysis, and Optimization

NASA Technical Reports Server (NTRS)

Meyn, Larry A.

2018-01-01

One of the goals of NASA's Revolutionary Vertical Lift Technology Project (RVLT) is to provide validated tools for multidisciplinary design, analysis and optimization (MDAO) of vertical lift vehicles. As part of this effort, the software package, RotorCraft Optimization Tools (RCOTOOLS), is being developed to facilitate incorporating key rotorcraft conceptual design codes into optimizations using the OpenMDAO multi-disciplinary optimization framework written in Python. RCOTOOLS, also written in Python, currently supports the incorporation of the NASA Design and Analysis of RotorCraft (NDARC) vehicle sizing tool and the Comprehensive Analytical Model of Rotorcraft Aerodynamics and Dynamics II (CAMRAD II) analysis tool into OpenMDAO-driven optimizations. Both of these tools use detailed, file-based inputs and outputs, so RCOTOOLS provides software wrappers to update input files with new design variable values, execute these codes and then extract specific response variable values from the file outputs. These wrappers are designed to be flexible and easy to use. RCOTOOLS also provides several utilities to aid in optimization model development, including Graphical User Interface (GUI) tools for browsing input and output files in order to identify text strings that are used to identify specific variables as optimization input and response variables. This paper provides an overview of RCOTOOLS and its use

Updated Liquid Secondary Waste Grout Formulation and Preliminary Waste Form Qualification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saslow, Sarah A.; Um, Wooyong; Russell, Renee L.

This report describes the results from liquid secondary waste grout (LSWG) formulation and cementitious waste form qualification tests performed by Pacific Northwest National Laboratory (PNNL) for Washington River Protection Solutions, LLC (WRPS). New formulations for preparing a cementitious waste form from a high-sulfate liquid secondary waste stream simulant, developed for Effluent Management Facility (EMF) process condensates merged with low activity waste (LAW) caustic scrubber, and the release of key constituents (e.g. 99Tc and 129I) from these monoliths were evaluated. This work supports a technology development program to address the technology needs for Hanford Site Effluent Treatment Facility (ETF) liquid secondarymore » waste (LSW) solidification and supports future Direct Feed Low-Activity Waste (DFLAW) operations. High-priority activities included simulant development, LSWG formulation, and waste form qualification. The work contained within this report relates to waste form development and testing and does not directly support the 2017 integrated disposal facility (IDF) performance assessment (PA). However, this work contains valuable information for use in PA maintenance past FY17, and for future waste form development efforts. The provided data should be used by (i) cementitious waste form scientists to further understanding of cementitious dissolution behavior, (ii) IDF PA modelers who use quantified constituent leachability, effective diffusivity, and partitioning coefficients to advance PA modeling efforts, and (iii) the U.S. Department of Energy (DOE) contractors and decision makers as they assess the IDF PA program. The results obtained help fill existing data gaps, support final selection of a LSWG waste form, and improve the technical defensibility of long-term waste form performance estimates.« less

Optical Measurements at the Combustor Exit of the HIFiRE 2 Ground Test Engine

NASA Technical Reports Server (NTRS)

Brown, Michael S.; Herring, Gregory C.; Cabell, Karen; Hass, Neal; Barhorst, Todd F.; Gruber, Mark

2012-01-01

The development of optical techniques capable of measuring in-stream flow properties of air breathing hypersonic engines is a goal of the Aerospace Propulsion Division at AFRL. Of particular interest are techniques such as tunable diode laser absorption spectroscopy that can be implemented in both ground and flight test efforts. We recently executed a measurement campaign at the exit of the combustor of the HIFiRE 2 ground test engine during Phase II operation of the engine. Data was collected in anticipation of similar data sets to be collected during the flight experiment. The ground test optical data provides a means to evaluate signal processing algorithms particularly those associated with limited line of sight tomography. Equally important, this in-stream data was collected to compliment data acquired with surface-mounted instrumentation and the accompanying flowpath modeling efforts-both CFD and lower order modeling. Here we discuss the specifics of hardware and data collection along with a coarse-grained look at the acquired data and our approach to processing and analyzing it.

Analysis of Prey-Predator Three Species Fishery Model with Harvesting Including Prey Refuge and Migration

NASA Astrophysics Data System (ADS)

Roy, Sankar Kumar; Roy, Banani

In this article, a prey-predator system with Holling type II functional response for the predator population including prey refuge region has been analyzed. Also a harvesting effort has been considered for the predator population. The density-dependent mortality rate for the prey, predator and super predator has been considered. The equilibria of the proposed system have been determined. Local and global stabilities for the system have been discussed. We have used the analytic approach to derive the global asymptotic stabilities of the system. The maximal predator per capita consumption rate has been considered as a bifurcation parameter to evaluate Hopf bifurcation in the neighborhood of interior equilibrium point. Also, we have used fishing effort to harvest predator population of the system as a control to develop a dynamic framework to investigate the optimal utilization of the resource, sustainability properties of the stock and the resource rent is earned from the resource. Finally, we have presented some numerical simulations to verify the analytic results and the system has been analyzed through graphical illustrations.

High Density, Insensitive Oxidizer With RDX Performance Final Report CRADA No. TC02178.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pagoria, P.; Preda, D.

2017-08-25

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Physical Sciences, Inc. (PSI), to develop a synthesis and evaluate a novel high density, insensitive oxidizer with RDX performance. This CRADA resulted from the award of a Phase I STTR ("STTR") from DOD. In recent years, the synthesis of new energetic heterocyclic compounds to replace the energetic materials currently in the stockpile has received a great amount of attention. The Office of the Secretary of Defense has identified that there is a need to incorporate new energetic materialsmore » in current and future weapon systems in an effort to increase performance and decrease sensitivity. For many of the future weapon systems, incorporation of energetic compounds currently in the stockpile will not provide the desired performance and sensitivity goals. The success of this CRADA may lead to a Phase I option STTR from DOD and to a Phase II STTR from DOD. The goal of this CRADA was to produce and test a novel oxidizer, 2,5,8-trinitroheptazine (TNH).« less

Comparison and Analysis of Zinc and Cobalt-Based Systems as Catalytic Entities for the Hydration of Carbon Dioxide

PubMed Central

Lau, Edmond Y.; Wong, Sergio E.; Baker, Sarah E.; Bearinger, Jane P.; Koziol, Lucas; Valdez, Carlos A.; Satcher, Joseph H.; Aines, Roger D.; Lightstone, Felice C.

2013-01-01

In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently catalyzes the conversion of carbon dioxide (CO2) to bicarbonate under physiological conditions. Many research efforts have been directed towards the development of small molecule mimetics that can facilitate this process and thus have a beneficial environmental impact, but these efforts have met very limited success. Herein, we undertook quantum mechanical calculations of four mimetics, 1,5,9-triazacyclododedacane, 1,4,7,10-tetraazacyclododedacane, tris(4,5-dimethyl-2-imidazolyl)phosphine, and tris(2-benzimidazolylmethyl)amine, in their complexed form either with the Zn2+ or the Co2+ ion and studied their reaction coordinate for CO2 hydration. These calculations demonstrated that the ability of the complex to maintain a tetrahedral geometry and bind bicarbonate in a unidentate manner were vital for the hydration reaction to proceed favorably. Furthermore, these calculations show that the catalytic activity of the examined zinc complexes was insensitive to coordination states for zinc, while coordination states above four were found to have an unfavorable effect on product release for the cobalt counterparts. PMID:23840420

An Unwilling Partnership With the Great Society Part II: Physicians Discover Malnutrition, Hunger and the Politics of Hunger.

PubMed

deShazo, Richard D; Smith, Robert; Minor, Wilson F Bill; Skipworth, Leigh Baldwin

2016-07-01

The civil rights and social legislation of the Great Society following the Civil Rights Act of 1964 was slow to provide relief for black in the South. Mississippi Senator James Eastland led an effort to defund Head Start, including his state's program, Child Development Group of Mississippi (CDGM), a program with a strong medical component. A senatorial committee, including Robert Kennedy, came to investigate CDGM in 1967. The unimaginable poverty, hunger, malnutrition and chronic disease found in black families was vehemently denied by Eastland. Visits of physician groups then corroborated the findings. The Mississippi delegation made sure that food relief never came and funding for CDGM ceased. Health services were lost to 6000 impoverished children. The epic television documentary, Hunger in America, soon premiered on network television. It triggered ongoing efforts to address health disparities, including implementation of the National Nutrition and Health Survey (NHANES). Similar physician leadership is needed to address the lasting health disparities in our country. Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Comparison and analysis of zinc and cobalt-based systems as catalytic entities for the hydration of carbon dioxide

DOE PAGES

Lau, E. Y.; Wong, S. E.; Baker, S. E.; ...

2013-06-20

In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently catalyzes the conversion of carbon dioxide (CO 2) to bicarbonate under physiological conditions. Efforts have been directed towards the development of small molecule mimetics that can facilitate this process and thus have a beneficial environmental impact, but these efforts have met very limited success. Herein, we undertook quantum mechanical calculations of four mimetics, 1,5,9-triazacyclododedacane, 1,4,7,10-tetraazacyclododedacane, tris(4,5-dimethyl-2-imidazolyl)phosphine, and tris(2-benzimidazolylmethyl)amine, in their complexed form either with the Zn 2+ or the Co 2+ ion and studied their reaction coordinate for CO 2 hydration. These calculations demonstrated that the ability of the complexmore » to maintain a tetrahedral geometry and bind bicarbonate in a unidentate manner were vital for the hydration reaction to proceed favorably. Moreover, these calculations show that the catalytic activity of the examined zinc complexes was insensitive to coordination states for zinc, while coordination states above four were found to have an unfavorable effect on product release for the cobalt counterparts.« less

DEFENSE TECHNOLOGY FOR ENVIRONMENTAL PROTECTION. VOLUME II. BIBLIOGRAPHY

EPA Science Inventory

The report condenses an effort design to identify and transfer significant technology concerned with air pollution monitoring and control from the Department of Defense (DOD) to the EPA. Included are technology profiles of each DOD laboratory involved in particular work of intere...

Assessing ConnDOT's portland cement concrete testing methods phase II : field trials and implementation.

DOT National Transportation Integrated Search

2012-04-01

This paper presents a description of efforts to disseminate findings from the Phase I study (SPR-2244), provides examples of applied maturity testing and temperature monitoring in Connecticut, reviews several State Highway Agency protocols for using ...

BUZZARDS BAY EMBAYMENTS, BAYWATCHERS II: NUTRIENT RELATED WATER QUALITY 1992-1998

EPA Science Inventory

Since 1992, the Buzzards Bay Citizens' Water Quality Monitoring Program, known as "Baywatchers", has been monitoring and evaluating bay water quality and particularly the impacts of nitrogen loading. More than 300 dedicated citizen volunteers have contributed to the effort, sampl...

FogEye UV Sensor System Evaluation : Phase II Report

DOT National Transportation Integrated Search

2003-12-01

The primary objective of the FogEye Evaluation Program is to determine whether coupled ultra-violet sources and detectors may provide enhancements to safety on the airport surface. The results of this effort will be used to complete the evaluation of...

Propaganda Posters.

ERIC Educational Resources Information Center

Mahaney, Darlene C.

2002-01-01

Provides a lesson that utilizes propaganda posters in order to teacher students about the U.S. homefront and war effort during World War II. Provides background information and posters for the teacher's use and explains that the students can use this information when creating their own propaganda posters. (CMK)

Lower Klickitat Riparian and In-channel Habitat Restoration Project; Klickitat Watershed Enhancement, Annual Report 2002-2003.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conley, Will

2004-01-01

The overall goal of the Klickitat Watershed Enhancement Project (KWEP) is to restore watershed health to aid recovery of salmonid stocks in the Klickitat subbasin. An emphasis is placed on restoration and protection of stream reaches and watersheds supporting native anadromous fish production, particularly steelhead (Oncorhyncus mykiss; ESA- listed as 'Threatened' within the Mid-Columbia ESU) and spring Chinook (O. tshawytscha). Habitat restoration activities in the Klickitat subbasin augment goals and objectives of the Yakima Klickitat Fisheries Project (YKFP), NPPC Fish and Wildlife Program, Klickitat Subbasin Summary and the NMFS Biological Opinion (All-H paper). Work is conducted to enhance instream andmore » contributing upland habitat to facilitate increased natural production potential for native salmonid stocks. Efforts in the Klickitat Subbasin fall into two main categories: (1) identification and prioritization of sites for protection and restoration activities, (2) implementation of protection and restoration measures. KWEP personnel also assist monitoring efforts of the YKFP Monitoring & Evaluation Project. During the September 2002-August 2003 reporting period, KWEP personnel continued efforts to address feedback from the August 2000 Provincial Review that indicated a need for better information management and development of geographic priorities by: (1) Assisting development of the Strategic Habitat Plan for the Klickitat Lead Entity (Task A3.1) and Klickitat steelhead EDT model (Task A4.1); (2) Improving the functionality of reference point, habitat unit, and large woody debris modules of the habitat database as well as addition of a temperature module (Tasks A1.1-1.2); (3) Continuing development and acquisition of GIS data (Task A1.3); (4) Ongoing data collection efforts to fill information gaps including streamflow, habitat, and temperature (Objectives C1 and C2); and (5) Completion of planning, field work, and hydrologic modeling associated with roads assessment in the White Creek watershed (Task A4.2). Significant milestones associated with restoration projects during the reporting period included: (1) Completion of the Surveyors Fish Creek Passage Enhancement project (Task B2.3); (2) Completion of interagency agreements for the Klickitat Meadows (Task B2.4) and Klickitat Mill (Task B2.10) projects; (3) Completion of topographic surveys for the Klickitat Meadows (Task B2.4), Klickitat River Meadows (Task B2.5), Trout Creek and Bear Creek culvert replacements (Task B2.7), and Snyder Swale II (Task B2.13) projects; (4) Completion of the Snyder Swale II - Phase 1 project (Task B2.13); (5) Completion of design, planning, and permitting for the Klickitat Mill project (Task B2.10) and initiation of construction; (6) Design for the Trout and Bear Creek culverts (B2.7) were brought to the 60% level; and (7) Completion of design work for the for the Klickitat Meadows (Task B2.4) and Klickitat River Meadows (Task B2.5) projects.« less

Come On! Using intervention mapping to help healthy pregnant women achieve healthy weight gain.

PubMed

Merkx, Astrid; Ausems, Marlein; de Vries, Raymond; Nieuwenhuijze, Marianne J

2017-06-01

Gaining too much or too little weight in pregnancy (according to Institute of Medicine (IOM) guidelines) negatively affects both mother and child, but many women find it difficult to manage their gestational weight gain (GWG). Here we describe the use of the intervention mapping protocol to design 'Come On!', an intervention to promote adequate GWG among healthy pregnant women. We used the six steps of intervention mapping: (i) needs assessment; (ii) formulation of change objectives; (iii) selection of theory-based methods and practical strategies; (iv) development of the intervention programme; (v) development of an adoption and implementation plan; and (vi) development of an evaluation plan. A consortium of users and related professionals guided the process of development. As a result of the needs assessment, two goals for the intervention were formulated: (i) helping healthy pregnant women to stay within the IOM guidelines for GWG; and (ii) getting midwives to adequately support the efforts of healthy pregnant women to gain weight within the IOM guidelines. To reach these goals, change objectives and determinants influencing the change objectives were formulated. Theories used were the Transtheoretical Model, Social Cognitive Theory and the Elaboration Likelihood Model. Practical strategies to use the theories were the foundation for the development of 'Come On!', a comprehensive programme that included a tailored Internet programme for pregnant women, training for midwives, an information card for midwives, and a scheduled discussion between the midwife and the pregnant woman during pregnancy. The programme was pre-tested and evaluated in an effect study.

Human-In-The-Loop Simulation in Support of Long-Term Sustainability of Light Water Reactors

DOE PAGES

Hallbert, Bruce P

2015-01-01

Reliable instrumentation, information, and control systems technologies are essential to ensuring safe and efficient operation of the U.S. light water reactor (LWR) fleet. These technologies affect every aspect of nuclear power plant (NPP) and balance-of-plant operations. In 1997, the National Research Council conducted a study concerning the challenges involved in modernization of digital instrumentation and control systems in NPPs. Their findings identified the need for new II&C technology integration. The NPP owners and operators realize that this analog technology represents a significant challenge to sustaining the operation of the current fleet of NPPs. Beyond control systems, new technologies are neededmore » to monitor and characterize the effects of aging and degradation in critical areas of key structures, systems, and components. The objective of the efforts sponsored by the U.S. Department of Energy is to develop, demonstrate, and deploy new digital technologies for II&C architectures and provide monitoring capabilities to ensure the continued safe, reliable, and economic operation of the nation’s NPPs.« less

SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus

DOE PAGES

Craig, Timothy; Smith, Andrew D.; Holder, Gareth M.; ...

2018-01-05

The development of more accurate and sensitive diagnostic techniques is a key factor in efforts to improve cancer survival rates. The technique of infrared aperture fibre scanning near-field optical microscopy (IR-SNOM),together with radiation from the infrared free-electron laser (IR-FEL) on ALICEat Daresbury Laboratory (UK), has been used to obtain IR images of a crypt-like feature and the surrounding tissue; the tissue was taken from a patient with oesophageal adenocarcinoma and with a history of Barrett’s oesophagus. We have shown that the DNA signal is enhanced relative to other contributions in the region of the crypt, and the glycoprotein signal showsmore » a less pronounced increase in the region of the crypt. The Amide II signal is found to be anti-correlated with the DNA and glycoprotein profiles. The absorbance of the Amide II signal is found to differ for three different types of cancer tissue. In conclusion, high-resolution IR images of the crypt reveal additional structure that would not be resolved in diffraction-limited techniques.« less

Automated Work Packages Prototype: Initial Design, Development, and Evaluation. Light Water Reactor Sustainability Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oxstrand, Johanna Helene; Ahmad Al Rashdan; Le Blanc, Katya Lee

The goal of the Automated Work Packages (AWP) project is to demonstrate how to enhance work quality, cost management, and nuclear safety through the use of advanced technology. The work described in this report is part of the digital architecture for a highly automated plant project of the technical program plan for advanced instrumentation, information, and control (II&C) systems technologies. This report addresses the DOE Milestone M2LW-15IN0603112: Describe the outcomes of field evaluations/demonstrations of the AWP prototype system and plant surveillance and communication framework requirements at host utilities. A brief background to the need for AWP research is provided, thenmore » two human factors field evaluation studies are described. These studies focus on the user experience of conducting a task (in this case a preventive maintenance and a surveillance test) while using an AWP system. The remaining part of the report describes an II&C effort to provide real time status updates to the technician by wireless transfer of equipment indications and a dynamic user interface.« less

Overview of ATMT and Analysis of Subphase IIB

DTIC Science & Technology

1977-12-01

relationships among maximum gunner error and target, vehicle motion. 1 INC LAS SI I F D I II TechidTfa-F ’•-RpoiTLTR-:7- 77 becemboer 1977 Directorate of...of- si ght interruptions, s ijrii i cant. difficulties weri etrcuo (t’red early in the effort to dioitize the anal uj iunnonr error dtta from thi s...and is classified SECRET. h. Phone I si •Jiu, ry. (I) The purpose of the Pha,ne I effort was to identify an array of co(.ddidate Lafneuvern ho b u.,ed

Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part I: Overview, vaccines for enteric viruses and Vibrio cholerae.

PubMed

O'Ryan, Miguel; Vidal, Roberto; del Canto, Felipe; Salazar, Juan Carlos; Montero, David

2015-01-01

Efforts to develop vaccines for prevention of acute diarrhea have been going on for more than 40 y with partial success. The myriad of pathogens, more than 20, that have been identified as a cause of acute diarrhea throughout the years pose a significant challenge for selecting and further developing the most relevant vaccine candidates. Based on pathogen distribution as identified in epidemiological studies performed mostly in low-resource countries, rotavirus, Cryptosporidium, Shigella, diarrheogenic E. coli and V. cholerae are predominant, and thus the main targets for vaccine development and implementation. Vaccination against norovirus is most relevant in middle/high-income countries and possibly in resource-deprived countries, pending a more precise characterization of disease impact. Only a few licensed vaccines are currently available, of which rotavirus vaccines have been the most outstanding in demonstrating a significant impact in a short time period. This is a comprehensive review, divided into 2 articles, of nearly 50 vaccine candidates against the most relevant viral and bacterial pathogens that cause acute gastroenteritis. In order to facilitate reading, sections for each pathogen are organized as follows: i) a discussion of the main epidemiological and pathogenic features; and ii) a discussion of vaccines based on their stage of development, moving from current licensed vaccines to vaccines in advanced stage of development (in phase IIb or III trials) to vaccines in early stages of clinical development (in phase I/II) or preclinical development in animal models. In this first article we discuss rotavirus, norovirus and Vibrio cholerae. In the following article we will discuss Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic), and Campylobacter jejuni.

Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part I: Overview, vaccines for enteric viruses and Vibrio cholerae

PubMed Central

O’Ryan, Miguel; Vidal, Roberto; del Canto, Felipe; Salazar, Juan Carlos; Montero, David

2015-01-01

Efforts to develop vaccines for prevention of acute diarrhea have been going on for more than 40 y with partial success. The myriad of pathogens, more than 20, that have been identified as a cause of acute diarrhea throughout the years pose a significant challenge for selecting and further developing the most relevant vaccine candidates. Based on pathogen distribution as identified in epidemiological studies performed mostly in low-resource countries, rotavirus, Cryptosporidium, Shigella, diarrheogenic E. coli and V. cholerae are predominant, and thus the main targets for vaccine development and implementation. Vaccination against norovirus is most relevant in middle/high-income countries and possibly in resource-deprived countries, pending a more precise characterization of disease impact. Only a few licensed vaccines are currently available, of which rotavirus vaccines have been the most outstanding in demonstrating a significant impact in a short time period. This is a comprehensive review, divided into 2 articles, of nearly 50 vaccine candidates against the most relevant viral and bacterial pathogens that cause acute gastroenteritis. In order to facilitate reading, sections for each pathogen are organized as follows: i) a discussion of the main epidemiological and pathogenic features; and ii) a discussion of vaccines based on their stage of development, moving from current licensed vaccines to vaccines in advanced stage of development (in phase IIb or III trials) to vaccines in early stages of clinical development (in phase I/II) or preclinical development in animal models. In this first article we discuss rotavirus, norovirus and Vibrio cholerae. In the following article we will discuss Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic), and Campylobacter jejuni. PMID:25715048

Monitoring trends in bat populations of the United States and territories: Problems and prospects

USGS Publications Warehouse

O'Shea, T.J.; Bogan, M. A.

2003-01-01

Bats are ecologically and economically important mammals. The life histories of bats (particularly their low reproductive rates and the need for some species to gather in large aggregations at limited numbers of roosting sites) make their populations vulnerable to declines. Many of the species of bats in the United States (U.S.) and territories are categorized as endangered or threatened, have been candidates for such categories, or are considered species of concern. The importance and vulnerability of bat populations makes monitoring trends in their populations a goal for their future management. However, scientifically rigorous monitoring of bat populations requires well-planned, statistically defensible efforts. This volume reports findings of an expert workshop held to examine the topic of monitoring populations of bats. The workshop participants included leading experts in sampling and analysis of wildlife populations, as well as experts in the biology and conservation of bats. Findings are reported in this volume under two sections. Part I of the report presents contributed papers that provide overviews of past and current efforts at monitoring trends in populations of bats in the U.S. and territories. These papers consider current techniques and problems, and summarize what is known about the status and trends in populations of selected groups of bats. The contributed papers in Part I also include a description of the monitoring program developed for bat populations in the United Kingdom, a critique of monitoring programs in wildlife in general with recommendations for survey and sampling strategies, and a compilation and analysis of existing data on trends in bats of the U.S. and territories. Efforts directed at monitoring bat populations are piecemeal and have shortcomings. In Part II of the report, the workshop participants provide critical analyses of these problems and develop recommendations for improving methods, defining objectives and priorities, gaining mandates, and enhancing information exchange to facilitate future efforts for monitoring trends in U.S. bat populations.

Believing is seeing: how people's beliefs influence goals, emotions and behaviour.

PubMed

Teunissen, Pim W; Bok, Harold G J

2013-11-01

Health care professionals work and learn in complex environments. Some are able to continue learning from their practice and the challenges it presents, whereas others refrain from investing more effort when faced with setbacks. This paper discusses a social cognitive model of motivation that helps to explain the different kinds of behaviour that emerge when individuals are confronted with challenges. Self-theories (people's theories on what competence is and means for the self) play a major role in establishing the goals people set for themselves, the emotions they experience and the meanings they attach to situations. These self-views are often not explicitly articulated and are therefore called 'implicit' ('self-') theories. Social cognitive research suggests there are two distinct ways of thinking about one's personal attributes: entity theorists view a trait as a fixed, concrete internal entity, whereas incremental theorists instead believe a trait to be something malleable that can be developed or cultivated through effort. Holding an entity theory leads one to set performance goals and to harbour concerns about performing well and making a good impression. Holding an incremental theory tends to lead one to set learning goals, and to focus less on performance and more on spending time and effort in determining which strategies work. The current literature on self-theories is used to explore the relevance of these theories in medical education in three contexts: (i) it is argued that, in order to support lifelong learning, both individual and organisational efforts fit best with an incremental outlook on professional development; (ii) if it is to move forward in the domain of feedback-seeking behaviour, medical education might benefit from a better understanding of the interactions among self-theories, feedback behaviour, and the pervading role of organisational culture, and (iii) the impact of self-theories on assessors' evaluations of performance. © 2013 John Wiley & Sons Ltd.

Raman spectra of solid benzene under high pressure

NASA Technical Reports Server (NTRS)

Thiery, M.-M.; Kobashi, K.; Spain, I. L.

1985-01-01

Raman spectra of solid benzene have been measured at room temperature up to about 140 kbar, using the diamond anvil cell. Effort has been focused upon the lattice vibration spectra at pressures above that of phase II. It is found that a change in slopes occurs in the frequency-pressure curves at about 40 kbar. Furthermore, a new band appears above 90 kbar. These features probably correspond respectively to the II-III phase transition, which has been reported previously, and a III-IV phase transition, reported here for the first time.

Commercial-Off-the-Shelf (COTS), Volatile Organic Compounds (VOCs) and Hazardous Air Pollutants (HAPs)-Free, Non-Chromate Low Temperature Powder Coating (LTPC) System for United States Air Force use (PHASE II )

DTIC Science & Technology

2017-09-12

and Hazardous Air Pollutants (HAPs)-Free, non -chromate low temperature powder coating (LTPC) system for United States Air Force use PHASE II PR...required to support and successfully complete this effort. 1.1 Objective(s). The Contractor shall be required to demonstrate a non -chromate...5.0 General Information 5.1 Continuation of Mission-Essential Services During a Crisis. The Functional Commander (FC) or civilian equivalent has

Youth Employment under Title II of the Job Training Partnership Act. Hearings before the Subcommittee on Employment and Productivity of the Committee on Labor and Human Resources. United States Senate, One Hundredth Congress, Second Session (February 2, April 27, June 8, and September 22, 1988).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

This document contains four Congressional hearings to review proposed legislation to revise certain youth employment provisions of Title II of the Job Training Partnership Act. This series of hearings looks into the whole question of how to improve the Federal Government's efforts to educate, train, and improve employment opportunities for the…

Americans with Disabilities Act (ADA) program review, training and support services.

DOT National Transportation Integrated Search

2010-12-01

This report describes research conducted for the New Jersey Department of Transportation (NJDOT) Division of Civil Rights to aid in its compliance efforts relative to Section 504 of the Rehabilitation Act of 1973 and Title II of the Americans with Di...

DOE SBIR DE-SC0011962 Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boucher, Yvan Anders; Kaye, William Robert

This report is to summarize the technical work completed during the phase I and phase II efforts by H3D for making gamma-ray imaging spectrometers for nuclear materials accounting and control. The report covers work completed between 6/9/2014 and 7/27/2017.

24 CFR 91.105 - Citizen participation plan; local governments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... report. (ii) These requirements are designed especially to encourage participation by low- and moderate... proposed to be used, and by residents of predominantly low- and moderate-income neighborhoods, as defined... efforts that encourage citizen participation in a shared vision for change in communities and...

Executive Functioning of Combat Mild Traumatic Brain Injury.

PubMed

Gaines, Katy D; Soper, Henry V; Berenji, Gholam R

2016-01-01

This study investigates neuropsychological deficits in recently deployed veterans with mild traumatic brain injury (mTBI). Veterans discharged from 2007 to 2012 were recruited from Veterans Affairs clinics. Independent groups of participants with mTBI (n = 57) and those without TBI (n = 57) were administered the Beck Depression Inventory-II, Combat Exposure Scale, Word Memory Test, and the Self-Awareness of Deficits Interview. Neuropsychological instruments included the Rey-Osterrieth Complex Figure Test, Letter and Category Fluency, Trail-Making Test-Parts A and B, Christiansen H-abbreviated, Soper Neuropsychology Screen, Wechsler Memory Scale subtests Logical Memory I and II, and the Street Completion Test. The mTBI group performed significantly worse on all of the executive and nonexecutive measurements with the exception of Category Fluency, after controlling for age, depression effort, and combat exposure. Depression and combat exposure were greater for the mTBI group. The mTBI group scored poorer on effort, but only the Multiple Choice subtest was significant. The mTBI group had good awareness of their deficits.

An overview of the Chemistry-Aerosol Mediterranean Experiment (ChArMEx)

NASA Astrophysics Data System (ADS)

Dulac, François

2014-05-01

The Chemistry-Aerosol Mediterranean Experiment (ChArMEx, http://charmex.lsce.ipsl.fr) is a French initiative of the MISTRALS meta-programme (Mediterranean Integrated Studies at Regional And Locals Scales, http://www.mistrals-home.org). It federates a great number of national and international cooperative research actions aiming at a scientific assessment of the present and future state of the atmospheric environment in the Mediterranean Basin, and of its impacts on the regional climate, air quality, and marine biogeochemistry. The target is short-lived particulate and gaseous tropospheric trace species which are the cause of poor air quality events, have two-way interactions with climate, or impact the marine biogeochemistry, in a context of strong regional anthropogenic and climatic pressures. The six ChArMEx work packages include Emissions, Chemical processes and ageing, Transport processes and air quality, Aerosol-radiation-climate interactions, Deposition, and Present and future variability and trends. For several years, efforts have been deployed in several countries to develop (i) a network of relevant stations for atmospheric chemistry at background sites on islands and continental coasts around the basin and (ii) several intensive field campaigns including the operation of surface supersites and various instrumented mobile platforms (large and ultra-light aircraft, sounding and drifting balloons, ZeroCO2 sailboat). This presentation is an attempt to provide an overview of the various experimental, remote sensing and modelling efforts produced and to highlight major findings, by referencing more detailed ChArMEx presentations given in this conference and recently published or submitted papers. During the first phase of the project experimental efforts have been mainly concentrated on the western basin. Plans for the 2nd phase of ChArMEx, more dedicated towards the eastern basin, will also be given. In particular we plan to develop monitoring activities at Cyprus and put more emphasis (i) on aerosol-cloud interactions in cooperation with the FP7/Environment project BACCHUS, (ii) the budget and transport of anthropogenic emissions from megacities, and (iii) processes at the air-sea interface with a proposal for a 1-month oceanographic cruise during a period of dust deposition events, joint with the biogeochemistry component of MISTRALS (project MERMEX: the Marine Ecosystem Response Mediterranean Experiment). Acknowledgements: ChArMEx activities involve about 50 institutes. FD expresses his gratitude to every contributing scientist. ChArMEx is supported by too many agencies for listing them all here. The main overall effort is from France, with ADEME, ANR, CNES, CNRS-INSU, the Collectivité Territoriale de Corse (incl. EU-FEDER funds), Météo-France, CEA and Ecole des Mines de Douai as the main funding agencies.

Income inequality widens the existing income-related disparity in depression risk in post-apartheid South Africa: Evidence from a nationally representative panel study.

PubMed

Burns, Jonathan K; Tomita, Andrew; Lund, Crick

2017-05-01

Income inequality (II) and poverty are major challenges in South Africa (SA) yet little is known about their interaction on population mental health. We explored relationships between district II, household income (HHI) and depressive symptoms in national panel data. We used 3 waves (2008, 2010, 2012) of the SA National Income Dynamics Study (n=25936) in adjusted mixed effects logistic regression to assess if the relationship between HHI and depressive symptoms is dependent on level of II. Depressive symptoms were assessed with Centre for Epidemiologic Studies Depression scale, and District inequality ratios (P10P90) derived from HHI distributions in 53 districts. Lower HHI and increasing II were associated with depressive symptoms. The interaction term between HHI and II on depressive symptoms was significant (β=0.01, 95% CI: <0.01-0.01); with increasing II and decreasing HHI, depression risk increased. II widens income-related disparities in depression risk in SA, with policy implications for understanding socioeconomic determinants of mental health and informing global efforts to reduce disparities in high poverty and inequality contexts. Copyright © 2017 Elsevier Ltd. All rights reserved.

Income inequality widens the existing income-related disparity in depression risk in post-apartheid South Africa: evidence from a nationally representative panel study

PubMed Central

Burns, Jonathan K; Tomita, Andrew; Lund, Crick

2017-01-01

Aim Income inequality (II) and poverty are major challenges in South Africa (SA) yet little is known about their interaction on population mental health. We explored relationships between district II, household income (HHI) and depressive symptoms in national panel data. Method We used 3 waves (2008, 2010, 2012) of the SA National Income Dynamics Study (n=25936) in adjusted mixed effects logistic regression to assess if the relationship between HHI and depressive symptoms is dependent on level of II. Depressive symptoms were assessed with Centre for Epidemiologic Studies Depression scale, and District inequality ratios (P10P90) derived from HHI distributions in 53 districts. Results Lower HHI and increasing II were associated with depressive symptoms. The interaction term between HHI and II on depressive symptoms was significant (β=0.01, 95% CI:<0.01–0.01); with increasing II and decreasing HHI, depression risk increased. Conclusion II widens income-related disparities in depression risk in SA, with policy implications for understanding socioeconomic determinants of mental health and informing global efforts to reduce disparities in high poverty and inequality contexts. PMID:28237744

Preliminary Evaluation of Air Quality Model Performance Utilizing Measurements at the University of Houston Moody Tower and others during the TexAQS-II

NASA Astrophysics Data System (ADS)

Byun, D. W.; Rappenglueck, B.; Lefer, B.

2007-12-01

Accurate meteorological and photochemical modeling efforts are necessary to understand the measurements made during the Texas Air Quality Study (TexAQS-II). The main objective of the study is to understand the meteorological and chemical processes of high ozone and regional haze events in the Eastern Texas, including the Houston-Galveston metropolitan area. Real-time and retrospective meteorological and photochemical model simulations were performed to study key physical and chemical processes in the Houston Galveston Area. In particular, the Vertical Mixing Experiment (VME) at the University of Houston campus was performed on selected days during the TexAQS-II. Results of the MM5 meteorological model and CMAQ air quality model simulations were compared with the VME and other TexAQS-II measurements to understand the interaction of the boundary layer dynamics and photochemical evolution affecting Houston air quality.

Biomass power for rural development. Technical progress report, July 1--September 30, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

The focus of the DOE/USDA sponsored biomass power for rural development project is to develop commercial energy crops for power generation by the year 2000. The New York based Salix Consortium project is a multi-partner endeavor, implemented in three stages. Phase-1, Final Design and Project Development, will conclude with the preparation of construction and/or operating permits, feedstock production plans, and contracts ready for signature. Field trials of willow (Salix) have been initiated at several locations in New York (Tully, Lockport, King Ferry, La Fayette, Massena, and Himrod) and co-firing tests are underway at Greenidge Station (NYSEG) and Dunkirk Station (NMPC).more » Phase-2 of the project will focus on scale-up of willow crop acreage, construction of co-firing facilities at Dunkirk Station (NMPC), and final modifications for Greenidge Station. Cofiring willow is also under consideration for GPU`s Seward Station where testing is underway. There will be an evaluation of the energy crop as part of the gasification trials occurring at BED`s McNeill power station. Phase-3 will represent fullscale commercialization of the energy crop and power generation on a sustainable basis. During the third quarter of 1997, much of the Consortium`s effort has focused on outreach activities, continued feedstock development, fuel supply planning, and fuel contract development, and preparation for 1998 scale-up activities. The Consortium also submitted a Phase-1 extension proposal during this period. A few of the more important milestones are outlined below. The fourth quarter of 1997 is expected to be dominated by Phase-II proposal efforts and planning for 1998 activities.« less

[Building bridges toward the 21st century].

PubMed

Sasaki, M

2000-10-01

Just as Rome was not built in a day, there are few great inventions and discoveries that can be made overnight. There are always historical circumstances behind them. Laboratory Automation is not an exception. With the end of World War II in 1945 as a turning point, a large volume of American medicine was introduced all over Japan, and clinical laboratory testing which was imported at the same time has taken root and matured. As a result, we can now carry out prompt and fully automated laboratory testing second to none at many hospital laboratories. In this paper, I recall the development and summarize the expansion by focusing on clinical laboratory automation as it has developed in the latter half of the 20th century in Japan. I would feel amply rewarded for my efforts if this paper proved helpful to the young generation. The clinical laboratory of the 21st century rests on their shoulders.

Evaluation of Castor Oil Cake Starch and Recovered Glycerol and Development of “Green” Composites Based on Those with Plant Fibers

PubMed Central

Guimarães, José Luis; Trindade Cursino, Ana Cristina; Ketzer Saul, Cyro; Sierrakowski, Maria Rita; Ramos, Luiz Pereira; Satyanarayana, Kestur Gundappa

2016-01-01

Continuous efforts are being made in some countries for the recovery of crude glycerin (RG/CG) and castor oil cake (COC), the two byproducts of biodiesel production. These are expected to help, not only in addressing environmental safety, but also in adding value to those byproducts, which otherwise may go to waste. Finding ways to utilize those byproducts underlines the main objective of this study. This paper presents the evaluation of (i) COC, glycerin and banana and sugarcane fibers for moisture content; (ii) COC for structural and thermal properties; and (iii) CG for its chemical characteristics. The possibility of using COC and CG with the selected fibers as reinforcement in the development of bio-composites is attempted through thermo-molding. Results revealed enhanced mechanical properties for these composites. The obtained results are discussed in terms of the observed morphology. PMID:28787878

Social and economic attitudes shaping American health policy.

PubMed

Fein, R

1980-01-01

The Health Clark Lectures (University of London) explore the development of American health care policy in a social and economic context; the probability of transatlantic relevance is substantial. I. American Health Care: Selected Policy Issues. The U.S. economy is beset with difficulties, and social policy bends to these realities and to perceptions of them. In the climate of growing neoconservatism, efforts to develop a coherent and cohesive national health policy are discontinuous and even inconsistent. II. Efficiency and Equity in Medicine: The Role of the Economist. The critical issue for economic policy is the amount spent for health care in society; for social policy it is the way that amount is shared. Certainly, there is an interplay between the two, but we must be wary of finding common ground in economic-investment and benefit-cost approaches. Striving for equity offers the best strategy to attain efficiency.

The United Nations programme on space applications: priority thematic areas

NASA Astrophysics Data System (ADS)

Haubold, H.

The Third United Nations Conference on the Exploration and Peaceful Uses of Outer Space (UNISPACE III) was held in 1999 with efforts to identify world wide benefits of developing space science and technology, particularly in the developing nations. One of the main vehicles to implement recommendations of UNISPACE III is the United Nations Programme on Space Applications of the Office for Outer Space Affairs at UN Headquarters in Vienna. Following a process of prioritization by Member States, the Programme focus its activities on (i) knowledge-based themes as space law and basic space science, (ii) application-based themes as disaster management, natural resources management, environmental monitoring, tele-health, and (iii) enabling technologies such as remote sensing satellites, communications satellites, global navigation satellite systems, and small satellites. Current activities of the Programme will be reviewed. Further information available at http://www.oosa.unvienna.org/sapidx.html

Compact, High Power, Multi-Spectral Mid-Infrared Semiconductor Laser Package

NASA Astrophysics Data System (ADS)

Guo, Bujin; Hwang, Wen-Yen; Lin, Chich-Hsiang

2001-10-01

Through a vertically integrated effort involving atomic level material engineering, advanced device processing development, state-of-the-art optomechanical packaging, and thermal management, Applied Optoelectronics, Inc. (AOI), University of Houston (U H), and Physical Science, Inc. (PSI) have made progress in both Sb-based type-II semiconductor material and in P-based type-I laser device development. We have achieved record performance on inP based quantum cascade continuous wave (CW) laser (with more than 5 mW CW power at 210 K). Grating-coupled external-cavity quantum cascade lasers were studied for temperatures from 20 to 230 K. A tuning range of 88 nm has been obtained at 80 K. The technology can be made commercially available and represents a significant milestone with regard to the Dual Use Science and Technology (DUST) intention of fostering dual use commercial technology for defense need. AOI is the first commercial company to ship products of this licensed technology.

The Russian effort in establishing large atomic and molecular databases

NASA Astrophysics Data System (ADS)

Presnyakov, Leonid P.

1998-07-01

The database activities in Russia have been developed in connection with UV and soft X-ray spectroscopic studies of extraterrestrial and laboratory (magnetically confined and laser-produced) plasmas. Two forms of database production are used: i) a set of computer programs to calculate radiative and collisional data for the general atom or ion, and ii) development of numeric database systems with the data stored in the computer. The first form is preferable for collisional data. At the Lebedev Physical Institute, an appropriate set of the codes has been developed. It includes all electronic processes at collision energies from the threshold up to the relativistic limit. The ion -atom (and -ion) collisional data are calculated with the methods developed recently. The program for the calculations of the level populations and line intensities is used for spectrical diagnostics of transparent plasmas. The second form of database production is widely used at the Institute of Physico-Technical Measurements (VNIIFTRI), and the Troitsk Center: the Institute of Spectroscopy and TRINITI. The main results obtained at the centers above are reviewed. Plans for future developments jointly with international collaborations are discussed.

Low Resolution Picture Transmission (LRPT) Demonstration System. Phase II; 1.0

NASA Technical Reports Server (NTRS)

Fong, Wai; Yeh, Pen-Shu; Duran, Steve; Sank, Victor; Nyugen, Xuan; Xia, Wei; Day, John H. (Technical Monitor)

2002-01-01

Low-Resolution Picture Transmission (LRPT) is a proposed standard for direct broadcast transmission of satellite weather images. This standard is a joint effort by the European Organization for the Exploitation of Meteorological Satellites (EUMETSAT) and NOAA. As a digital transmission scheme, its purpose is to replace the current analog Automatic Picture Transmission (APT) system for use in the Meteorological Operational (METOP) satellites. GSFC has been tasked to build an LRPT Demonstration System (LDS). Its main objective is to develop or demonstrate the feasibility of a low-cost receiver utilizing a PC as the primary processing component and determine the performance of the protocol in the simulated Radio Frequency (RF) environment. The approach would consist of two phases.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bates, L.D.

Oak Ridge National Laboratory (ORNL) is a principle Department of Energy (DOE) Research Institution operated by the Union Carbide Corporation - Nuclear Division (UCC-ND) under direction of the DOE Oak Ridge Operations Office (DOE-ORO). The Laboratory was established in east Tennessee, near what is now the city of Oak Ridge, in the mid 1940s as a part of the World War II effort to develop a nuclear weapon. Since its inception, disposal of radioactively contaminated materials, both solid and liquid, has been an integral part of Laboratory operations. The purpose of this document is to provide a detailed description ofmore » the ORNL Solid Waste Storage Areas, to describe the practice and procedure of their operation, and to address the health and safety impacts and concerns of that operation.« less

Desensitized Optimal Filtering and Sensor Fusion Toolkit

NASA Technical Reports Server (NTRS)

Karlgaard, Christopher D.

2015-01-01

Analytical Mechanics Associates, Inc., has developed a software toolkit that filters and processes navigational data from multiple sensor sources. A key component of the toolkit is a trajectory optimization technique that reduces the sensitivity of Kalman filters with respect to model parameter uncertainties. The sensor fusion toolkit also integrates recent advances in adaptive Kalman and sigma-point filters for non-Gaussian problems with error statistics. This Phase II effort provides new filtering and sensor fusion techniques in a convenient package that can be used as a stand-alone application for ground support and/or onboard use. Its modular architecture enables ready integration with existing tools. A suite of sensor models and noise distribution as well as Monte Carlo analysis capability are included to enable statistical performance evaluations.

Background Characterization and Discrimination in the Final Analysis of the CDMS II Phase of the Cryogenic Dark Matter Search

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fritts, Matthew C.

The Cryogenic Dark Matter Search (CDMS) is designed to detectWeakly-Interacting Massive Particles (WIMPs) in the Milky Way halo. The phase known as CDMS II was performed in the Soudan Underground Laboratory. The final set of CDMS II data, collected in 2007-8 and referred to as Runs 125-8, represents the largest exposure to date for the experiment. We seek collisions between WIMPs and atomic nuclei in disk-shaped germanium and silicon detectors. A key design feature is to keep the rate of collisions from known particles producing WIMP-like signals very small. The largest category of such background is interactions with electrons inmore » the detectors that occur very close to one of the faces of the detector. The next largest category is collisions between energetic neutrons that bypass the experimental shielding and nuclei in the detectors. Analytical efforts to discriminate these backgrounds and to estimate the rate at which such discrimination fails have been refined and improved throughout each phase of CDMS. Next-generation detectors for future phases of CDMS require testing at cryogenic test facilities. One such facility was developed at the University of Minnesota in 2007 and has been used continuously since then to test detectors for the next phase of the experiment, known as SuperCDMS.« less

Synthesis, spectroscopic characterization, DFT optimization and biological activities of Schiff bases and their metal (II) complexes

NASA Astrophysics Data System (ADS)

Rauf, Abdur; Shah, Afzal; Munawar, Khurram Shahzad; Khan, Abdul Aziz; Abbasi, Rashda; Yameen, Muhammad Arfat; Khan, Asad Muhammad; Khan, Abdur Rahman; Qureshi, Irfan Zia; Kraatz, Heinz-Bernhard; Zia-ur-Rehman

2017-10-01

A Novel Schiff base, 3-(((4-chlorophenyl)imino)methyl)benzene-1,2-diol (HL1) was successfully synthesized along with a structurally similar Schiff base 3-(((4-bromophenyl)imino)methyl)benzene-1,2-diol (HL2). Both the Schiff bases were used to synthesize their zinc (II) and cobalt (II) complexes. These compounds were characterized by FTIR, 1H NMR, 13C NMR and elemental analysis. Metal complexes were confirmed by TGA. Crystals of Schiff bases were also characterized by X-ray analysis and experimental parameters were found in line with the theoretical parameters. Quantum mechanical approach was also used to fine useful structural parameters and to ensure the geometry of metal complexes. The photometric behaviors of all the synthesized compounds were investigated in a wide pH range using BR buffers. The appearance of isosbestic points indicated the existence of Schiff bases in more than one isomeric form. Moreover, these compounds were screened for enzyme inhibition; antibacterial, cytotoxic and in vivo antidiabetic activities and compounds were found active against one or other activity. Results indicate that ZnL22 is a good inhibitor of alkaline phosphatase enzyme and possess highest potential against diabetes, blood cholesterol level and cancer cells. This effort just provides preliminary data for some biological properties. Further investigations are required to precisely determine mechanistic pathways of their use towards drug development.

POLLUTION FROM THE COMBINED ACTIVITIES, ACTIONS, AND BEHAVIORS OF THE PUBLIC: PHARMACEUTICALS AND PERSONAL CARE PRODUCTS

EPA Science Inventory

ORD's four-fold objectives in its efforts have been to: (i) Identify potential (future) environmental concerns (anticipatory research and identification of emerging issues, especially to identify pivotal sources of uncertainty that might affect risk estimates), (ii) Be proactive ...

Comprehensive Planning.

ERIC Educational Resources Information Center

Pavlenko, Victor V.

Comprehensive planning, defined as the work of those who engage in efforts, within a delimited geographic area, to identify and order the physical, social, and economic relationships of that area, is discussed in the four sections of this paper. Section I, Introduction, describes what "planning" and "comprehensive planning" are. In Section II, Why…

SCIENTIFIC UNCERTAINTIES IN ATMOSPHERIC MERCURY MODELS II: SENSITIVITY ANALYSIS IN THE CONUS DOMAIN

EPA Science Inventory

In this study, we present the response of model results to different scientific treatments in an effort to quantify the uncertainties caused by the incomplete understanding of mercury science and by model assumptions in atmospheric mercury models. Two sets of sensitivity simulati...

SOLVENT-BASED TO WATERBASED ADHESIVE-COATED SUBSTRATE RETROFIT - VOLUME II: PROCESS OVERVIEW

EPA Science Inventory

This volume presents initial results of a study to identify the issues and barriers associated with retrofitting existing solvent-based equipment to accept waterbased adhesives as part of an EPA effort to improve equipment cleaning in the coated and laminated substrate manufactur...

23 CFR 1345.5 - Requirements for a grant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... chronological order: (i) A seat belt observed use survey conducted before any enforcement wave; (ii) A media.... (iii) Local media events announcing a pending enforcement wave; (iv) A wave of enforcement effort consisting of checkpoints, saturation patrols or other enforcement tactics. (v) A post-wave observed use...

Steve Hammond | NREL

Science.gov Websites

Hammond Photo of Steven Hammond Steve Hammond Center Director II-Technical Steven.Hammond@nrel.gov | 303-275-4121 Steve Hammond is director of the Computational Science Center at the National Renewable includes leading NREL's efforts in energy efficient data centers. Prior to NREL, Steve managed the

Characterization of PVT Grown ZnSe by Low Temperature Photoluminescence

NASA Technical Reports Server (NTRS)

Wang, Ling Jun

1998-01-01

ZnSe, a II-VI semiconductor with a large direct band gap of 2.7 eV at room temperature and 2.82 eV at 10 K, is considered a promising material for optoelectric applications in the blue-green region of the spectrum. Photoemitting devices and diode laser action has been demonstrated as a result of decades of research. A key issue in the development of II-VI semiconductors is the control of the concentration of the various impurities. The II-VI semiconductors seem to defy the effort of high level doping due to the well known self compensation of the donors and the acceptors. A good understanding of roles of the impurities and the behavior of the various intrinsic defects such as vacancies, interstitials and their complexes with impurities is necessary in the development and application of these materials. Persistent impurities such as Li and Cu have long played a central role in the photoelectronic properties of many II-VI compounds, particularly ZnSe. The shallow centers which may promote useful electrical conductivity are of particular interest. They contribute the richly structured near gap edge luminescence, containing weak to moderate phonon coupling and therefore very accessible information about the energy states of the different centers. Significance of those residual impurities which may contribute such centers in II-VI semiconductors must be fully appreciated before improved control of their electrical properties may be possible. Low temperature photoluminescence spectroscopy is an important source of information and a useful tool of characterization of II-VI semiconductors such as ZnSe. The low temperature photoluminescence spectrum of a ZnSe single crystal typically consists of a broad band emission peaking at 2.34 eV, known as the Cu-green band, and some very sharp lines near the band gap. These bands and lines are used to identify the impurity ingredients and the defects. The assessment of the quality of the crystal based on the photoluminescence analysis is then possible. In this report we present the characterization of a ZnSe single crystal as grown by the physical vapor transport method, with special intention paid to the possible effects of the gravitational field to the growth of the crystal.

Feature Reinforcement Learning: Part I. Unstructured MDPs

NASA Astrophysics Data System (ADS)

Hutter, Marcus

2009-12-01

General-purpose, intelligent, learning agents cycle through sequences of observations, actions, and rewards that are complex, uncertain, unknown, and non-Markovian. On the other hand, reinforcement learning is well-developed for small finite state Markov decision processes (MDPs). Up to now, extracting the right state representations out of bare observations, that is, reducing the general agent setup to the MDP framework, is an art that involves significant effort by designers. The primary goal of this work is to automate the reduction process and thereby significantly expand the scope of many existing reinforcement learning algorithms and the agents that employ them. Before we can think of mechanizing this search for suitable MDPs, we need a formal objective criterion. The main contribution of this article is to develop such a criterion. I also integrate the various parts into one learning algorithm. Extensions to more realistic dynamic Bayesian networks are developed in Part II (Hutter, 2009c). The role of POMDPs is also considered there.

Fuel-Flexible Gasification-Combustion Technology for Production of H2 and Sequestration-Ready CO2

DOE Office of Scientific and Technical Information (OSTI.GOV)

George Rizeq; Parag Kulkarni; Wei Wei

It is expected that in the 21st century the Nation will continue to rely on fossil fuels for electricity, transportation, and chemicals. It will be necessary to improve both the process efficiency and environmental impact performance of fossil fuel utilization. GE Global Research is developing an innovative fuel-flexible Unmixed Fuel Processor (UFP) technology to produce H{sub 2}, power, and sequestration-ready CO{sub 2} from coal and other solid fuels. The UFP module offers the potential for reduced cost, increased process efficiency relative to conventional gasification and combustion systems, and near-zero pollutant emissions including NO{sub x}. GE was awarded a contract frommore » U.S. DOE NETL to develop the UFP technology. Work on the Phase I program started in October 2000, and work on the Phase II effort started in April 2005. In the UFP technology, coal and air are simultaneously converted into separate streams of (1) high-purity hydrogen that can be utilized in fuel cells or turbines, (2) sequestration-ready CO{sub 2}, and (3) high temperature/pressure vitiated air to produce electricity in a gas turbine. The process produces near-zero emissions with an estimated efficiency higher than IGCC with conventional CO2 separation. The Phase I R&D program established the feasibility of the integrated UFP technology through lab-, bench- and pilot-scale testing and investigated operating conditions that maximize separation of CO{sub 2} and pollutants from the vent gas, while simultaneously maximizing coal conversion efficiency and hydrogen production. The Phase I effort integrated experimental testing, modeling and preliminary economic studies to demonstrate the UFP technology. The Phase II effort will focus on three high-risk areas: economics, sorbent attrition and lifetime, and product gas quality for turbines. The economic analysis will include estimating the capital cost as well as the costs of hydrogen and electricity for a full-scale UFP plant. These costs will be benchmarked with IGCC polygen costs for plants of similar size. Sorbent attrition and lifetime will be addressed via bench-scale experiments that monitor sorbent performance over time and by assessing materials interactions at operating conditions. The product gas from the third reactor (high-temperature vitiated air) will be evaluated to assess the concentration of particulates, pollutants and other impurities relative to the specifications required for gas turbine feed streams. This is the eighteenth quarterly technical progress report for the UFP program, which is supported by U.S. DOE NETL (Contract No. DE-FC26-00FT40974) and GE. This report summarizes program accomplishments for the Phase II period starting July 01, 2005 and ending September 30, 2005. The report includes an introduction summarizing the UFP technology, main program tasks, and program objectives; it also provides a summary of program activities and accomplishments covering progress in tasks including process modeling, scale-up and economic analysis.« less

The path to a successful one-million tonne demonstration of geological sequestration: Characterization, cooperation, and collaboration

USGS Publications Warehouse

Finley, R.J.; Greenberg, S.E.; Frailey, S.M.; Krapac, I.G.; Leetaru, H.E.; Marsteller, S.

2011-01-01

The development of the Illinois Basin-Decatur USA test site for a 1 million tonne injection of CO2 into the Mount Simon Sandstone saline reservoir beginning in 2011 has been a multiphase process requiring a wide array of personnel and resources that began in 2003. The process of regional characterization took two years as part of a Phase I effort focused on the entire Illinois Basin, located in Illinois, Indiana, and Kentucky, USA. Seeking the cooperation of an industrial source of CO2 and site selection within the Basin took place during Phase II while most of the concurrent research emphasis was on a set of small-scale tests of Enhanced Oil Recovery (EOR) and CO2 injection into a coal seam. Phase III began the commitment to the 1 million-tonne test site development through the collaboration of the Archer Daniels Midland Company (ADM) who is providing a site, the CO2, and developing a compression facility, of Schlumberger Carbon Services who is providing expertise for operations, drilling, geophysics, risk assessment, and reservoir modelling, and of the Illinois State Geological Survey (ISGS) whose geologists and engineers lead the Midwest Geological Sequestration Consortium (MGSC). Communications and outreach has been a collaborative effort of ADM, ISGS and Schlumberger Carbon Services. The Consortium is one of the seven Regional Carbon Sequestration Partnerships, a carbon sequestration research program supported by the National Energy Technology Laboratory of the U.S. Department of Energy. ?? 2011 Published by Elsevier Ltd.

MURMoT. Design and Application of Microbial Uranium Reduction Monitoring Tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loeffler, Frank E.

2014-12-31

Uranium (U) contamination in the subsurface is a major remediation challenge at many DOE sites. Traditional site remedies present enormous costs to DOE; hence, enhanced bioremediation technologies (i.e., biostimulation and bioaugmentation) combined with monitoring efforts are being considered as cost-effective corrective actions to address subsurface contamination. This research effort improved understanding of the microbial U reduction process and developed new tools for monitoring microbial activities. Application of these tools will promote science-based site management decisions that achieve contaminant detoxification, plume control, and long-term stewardship in the most efficient manner. The overarching hypothesis was that the design, validation and application ofmore » a suite of new molecular and biogeochemical tools advance process understanding, and improve environmental monitoring regimes to assess and predict in situ U immobilization. Accomplishments: This project (i) advanced nucleic acid-based approaches to elucidate the presence, abundance, dynamics, spatial distribution, and activity of metal- and radionuclide-detoxifying bacteria; (ii) developed proteomics workflows for detection of metal reduction biomarker proteins in laboratory cultures and contaminated site groundwater; (iii) developed and demonstrated the utility of U isotopic fractionation using high precision mass spectrometry to quantify U(VI) reduction for a range of reduction mechanisms and environmental conditions; and (iv) validated the new tools using field samples from U-contaminated IFRC sites, and demonstrated their prognostic and diagnostic capabilities in guiding decision making for environmental remediation and long-term site stewardship.« less

Remote Sensing Applications to Water Quality Management in Florida

NASA Astrophysics Data System (ADS)

Lehrter, J. C.; Schaeffer, B. A.; Hagy, J.; Spiering, B.; Barnes, B.; Hu, C.; Le, C.; McEachron, L.; Underwood, L. W.; Ellis, C.; Fisher, B.

2013-12-01

Optical datasets from estuarine and coastal systems are increasingly available for remote sensing algorithm development, validation, and application. With validated algorithms, the data streams from satellite sensors can provide unprecedented spatial and temporal data for local and regional coastal water quality management. Our presentation will highlight two recent applications of optical data and remote sensing to water quality decision-making in coastal regions of the state of Florida; (1) informing the development of estuarine and coastal nutrient criteria for the state of Florida and (2) informing the rezoning of the Florida Keys National Marine Sanctuary. These efforts involved building up the underlying science to demonstrate the applicability of satellite data as well as an outreach component to educate decision-makers about the use, utility, and uncertainties of remote sensing data products. Scientific developments included testing existing algorithms and generating new algorithms for water clarity and chlorophylla in case II (CDOM or turbidity dominated) estuarine and coastal waters and demonstrating the accuracy of remote sensing data products in comparison to traditional field based measurements. Including members from decision-making organizations on the research team and interacting with decision-makers early and often in the process were key factors for the success of the outreach efforts and the eventual adoption of satellite data into the data records and analyses used in decision-making. Florida coastal water bodies (black boxes) for which remote sensing imagery were applied to derive numeric nutrient criteria and in situ observations (black dots) used to validate imagery. Florida ocean color applied to development of numeric nutrient criteria

Weekday and weekend moderate to vigorous physical activity of young musicians in the context of public health recommendations.

PubMed

Nawrocka, Agnieszka; Mynarski, Władysław; Grabara, Małgorzata; Powerska-Didkowska, Aneta; Borek, Zbigniew

2013-01-01

Physical activity is very important for the proper mental and physical development of children and youths, especially for the development of the locomotor system. The students of music schools are a unique group of children and youths, because of specific loads on the organs of locomotion, associated with the playing of musical instruments. They can therefore be exposed to a variety of health problems, particularly in the case of insufficient physical activity. The aim of the presented study was to assess the level of physical activity of music schools' students on weekdays and weekends against the parameters of physical efforts beneficial to health. The study involved 225 musicians from the Katowice School of Music, Complex of I and II degrees, aged 10-18 years (138 girls and 87 boys). The level of physical activity was assessed on the basis of moderate to vigorous rates (MVPA). Both on weekdays as well as at the weekends, boys presented a higher level of physical activity of at least moderate intensity (MVPA), which also resulted in a greater total weekly pro-health physical activity. Both boys and girls dedicated significantly more time to beneficial pro-health efforts physical health at weekends (p<0.01). The percentage of young musicians who meet accepted (in this study) standards for the optimal amount of physical activity in both groups was dramatically low (3.6% of girls and 11.5% of boys). Both boys and girls from the music schools often undertake moderate to vigorous physical activity (MVPA) at the weekends. The boys more often than the girls made pro-health physical efforts of moderate and high intensity.

Prediction and analysis of promiscuous T cell-epitopes derived from the vaccine candidate antigens of Leishmania donovani binding to MHC class-II alleles using in silico approach.

PubMed

Kashyap, Manju; Jaiswal, Varun; Farooq, Umar

2017-09-01

Visceral leishmaniasis is a dreadful infectious disease and caused by the intracellular protozoan parasites, Leishmania donovani and Leishmania infantum. Despite extensive efforts for developing effective prophylactic vaccine, still no vaccine is available against leishmaniasis. However, advancement in immunoinformatics methods generated new dimension in peptide based vaccine development. The present study was aimed to identify T-cell epitopes from the vaccine candidate antigens like Lipophosphogylcan-3(LPG-3) and Nucleoside hydrolase (NH) from the L. donovani using in silico methods. Available best tools were used for the identification of promiscuous peptides for MHC class-II alleles. A total of 34 promiscuous peptides from LPG-3, 3 from NH were identified on the basis of their 100% binding affinity towards all six HLA alleles, taken in this study. These peptides were further checked computationally to know their IFN-γ and IL4 inducing potential and nine peptides were identified. Peptide binding interactions with predominant HLA alleles were done by docking. Out of nine docked promiscuous peptides, only two peptides (QESRILRVIKKKLVR, RILRVIKKKLVRKTL), from LPG-3 and one peptide (FDKFWCLVIDALKRI) from NH showed lowest binding energy with all six alleles. These promiscuous T-cell epitopes were predicted on the basis of their antigenicity, hydrophobicity, potential immune response and docking scores. The immunogenicity of predicted promiscuous peptides might be used for subunit vaccine development with immune-modulating adjuvants. Copyright © 2017 Elsevier B.V. All rights reserved.

Antibiotics: natural products essential to human health.

PubMed

Demain, Arnold L

2009-11-01

For more than 50 years, natural products have served us well in combating infectious bacteria and fungi. Microbial and plant secondary metabolites helped to double our life span during the 20th century, reduced pain and suffering, and revolutionized medicine. Most antibiotics are either (i) natural products of microorganisms, (ii) semi-synthetically produced from natural products, or (iii) chemically synthesized based on the structure of the natural products. Production of antibiotics began with penicillin in the late 1940s and proceeded with great success until the 1970-1980s when it became harder and harder to discover new and useful products. Furthermore, resistance development in pathogens became a major problem, which is still with us today. In addition, new pathogens are continually emerging and there are still bacteria that are not eliminated by any antibiotic, e.g., Pseudomonas aeruginosa. In addition to these problems, many of the major pharmaceutical companies have abandoned the antibiotic field, leaving much of the discovery efforts to small companies, new companies, and the biotechnology industries. Despite these problems, development of new antibiotics has continued, albeit at a much lower pace than in the last century. We have seen the (i) appearance of newly discovered antibiotics (e.g., candins), (ii) development of old but unutilized antibiotics (e.g., daptomycin), (iii) production of new semi-synthetic versions of old antibiotics (e.g., glycylcyclines, streptogrammins), as well as the (iv) very useful application of old but underutilized antibiotics (e.g., teicoplanin).

A decision support model for improving a multi-family housing complex based on CO2 emission from electricity consumption.

PubMed

Hong, Taehoon; Koo, Choongwan; Kim, Hyunjoong

2012-12-15

The number of deteriorated multi-family housing complexes in South Korea continues to rise, and consequently their electricity consumption is also increasing. This needs to be addressed as part of the nation's efforts to reduce energy consumption. The objective of this research was to develop a decision support model for determining the need to improve multi-family housing complexes. In this research, 1664 cases located in Seoul were selected for model development. The research team collected the characteristics and electricity energy consumption data of these projects in 2009-2010. The following were carried out in this research: (i) using the Decision Tree, multi-family housing complexes were clustered based on their electricity energy consumption; (ii) using Case-Based Reasoning, similar cases were retrieved from the same cluster; and (iii) using a combination of Multiple Regression Analysis, Artificial Neural Network, and Genetic Algorithm, the prediction performance of the developed model was improved. The results of this research can be used as follows: (i) as basic research data for continuously managing several energy consumption data of multi-family housing complexes; (ii) as advanced research data for predicting energy consumption based on the project characteristics; (iii) as practical research data for selecting the most optimal multi-family housing complex with the most potential in terms of energy savings; and (iv) as consistent and objective criteria for incentives and penalties. Copyright © 2012 Elsevier Ltd. All rights reserved.

An Examination of the Changes in Science Teaching Orientations and Technology-Enhanced Tools for Student Learning in the Context of Professional Development

NASA Astrophysics Data System (ADS)

Campbell, Todd; Zuwallack, Rebecca; Longhurst, Max; Shelton, Brett E.; Wolf, Paul G.

2014-07-01

This research examines how science teaching orientations and beliefs about technology-enhanced tools change over time in professional development (PD). The primary data sources for this study came from learning journals of 8 eighth grade science teachers at the beginning and conclusion of a year of PD. Based on the analysis completed, Information Transmission (IT) and Struggling with Standards-Based Reform (SSBR) profiles were found at the beginning of the PD, while SSBR and Standards-Based Reform (SBR) profiles were identified at the conclusion of PD. All profiles exhibited Vision I beliefs about the goals and purposes for science education, while only the SBR profile exhibited Vision II goals and purposes for science teaching. The IT profile demonstrated naïve or unrevealed beliefs about the nature of science, while the SSBR and SBR profiles had more sophisticated beliefs in this area. The IT profile was grounded in more teacher-centered beliefs about science teaching and learning as the other two profiles revealed more student-centered beliefs. While no beliefs about technology-enhanced tools were found for the IT profile, these were found for the other two profiles. Our findings suggest promising implications for (a) Roberts' Vision II as a central support for reform efforts, (b) situating technology-enhanced tools within the beliefs about science teaching and learning dimension of science teaching orientations, and (c) revealing how teacher orientations develop as a result of PD.

Development of the National Health Information Systems in Botswana: Pitfalls, prospects and lessons.

PubMed

Seitio-Kgokgwe, Onalenna; Gauld, Robin D C; Hill, Philip C; Barnett, Pauline

2015-01-01

Studies evaluating development of health information systems in developing countries are limited. Most of the available studies are based on pilot projects or cross-sectional studies. We took a longitudinal approach to analysing the development of Botswana's health information systems. We aimed to: (i) trace the development of the national health information systems in Botswana (ii) identify pitfalls during development and prospects that could be maximized to strengthen the system; and (iii) draw lessons for Botswana and other countries working on establishing or improving their health information systems. This article is based on data collected through document analysis and key informant interviews with policy makers, senior managers and staff of the Ministry of Health and senior officers from various stakeholder organizations. Lack of central coordination, weak leadership, weak policy and regulatory frameworks, and inadequate resources limited development of the national health information systems in Botswana. Lack of attention to issues of organizational structure is one of the major pitfalls. The ongoing reorganization of the Ministry of Health provides opportunity to reposition the health information system function. The current efforts including development of the health information management policy and plan could enhance the health information management system.

Putting tools in the toolbox: Development of a free, open-source toolbox for quantitative image analysis of porous media.

NASA Astrophysics Data System (ADS)

Iltis, G.; Caswell, T. A.; Dill, E.; Wilkins, S.; Lee, W. K.

2014-12-01

X-ray tomographic imaging of porous media has proven to be a valuable tool for investigating and characterizing the physical structure and state of both natural and synthetic porous materials, including glass bead packs, ceramics, soil and rock. Given that most synchrotron facilities have user programs which grant academic researchers access to facilities and x-ray imaging equipment free of charge, a key limitation or hindrance for small research groups interested in conducting x-ray imaging experiments is the financial cost associated with post-experiment data analysis. While the cost of high performance computing hardware continues to decrease, expenses associated with licensing commercial software packages for quantitative image analysis continue to increase, with current prices being as high as $24,000 USD, for a single user license. As construction of the Nation's newest synchrotron accelerator nears completion, a significant effort is being made here at the National Synchrotron Light Source II (NSLS-II), Brookhaven National Laboratory (BNL), to provide an open-source, experiment-to-publication toolbox that reduces the financial and technical 'activation energy' required for performing sophisticated quantitative analysis of multidimensional porous media data sets, collected using cutting-edge x-ray imaging techniques. Implementation focuses on leveraging existing open-source projects and developing additional tools for quantitative analysis. We will present an overview of the software suite that is in development here at BNL including major design decisions, a demonstration of several test cases illustrating currently available quantitative tools for analysis and characterization of multidimensional porous media image data sets and plans for their future development.

LiverTox: Advanced QSAR and Toxicogeomic Software for Hepatotoxicity Prediction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, P-Y.; Yuracko, K.

2011-02-25

YAHSGS LLC and Oak Ridge National Laboratory (ORNL) established a CRADA in an attempt to develop a predictive system using a pre-existing ORNL computational neural network and wavelets format. This was in the interest of addressing national needs for toxicity prediction system to help overcome the significant drain of resources (money and time) being directed toward developing chemical agents for commerce. The research project has been supported through an STTR mechanism and funded by the National Institute of Environmental Health Sciences beginning Phase I in 2004 (CRADA No. ORNL-04-0688) and extending Phase II through 2007 (ORNL NFE-06-00020). To attempt themore » research objectives and aims outlined under this CRADA, state-of-the-art computational neural network and wavelet methods were used in an effort to design a predictive toxicity system that used two independent areas on which to base the system’s predictions. These two areas were quantitative structure-activity relationships and gene-expression data obtained from microarrays. A third area, using the new Massively Parallel Signature Sequencing (MPSS) technology to assess gene expression, also was attempted but had to be dropped because the company holding the rights to this promising MPSS technology went out of business. A research-scale predictive toxicity database system called Multi-Intelligent System for Toxicogenomic Applications (MISTA) was developed and its feasibility for use as a predictor of toxicological activity was tested. The fundamental focus of the CRADA was an attempt and effort to operate the MISTA database using the ORNL neural network. This effort indicated the potential that such a fully developed system might be used to assist in predicting such biological endpoints as hepatotoxcity and neurotoxicity. The MISTA/LiverTox approach if eventually fully developed might also be useful for automatic processing of microarray data to predict modes of action. A technical paper describing the methods and technology used in the CRADA has been published. This paper was entitled “A Toxicity Evaluation and Predictive System Based on Neural Networks and Wavelets” and appeared in an American Chemical Society peer-reviewed publication this year (J. Chem. Inf. Model. 47: 676685, 2007). A patent application was filed but later abandoned.« less

Use of ferrous iron by metallo-β-lactamases.

PubMed

Cahill, Samuel T; Tarhonskaya, Hanna; Rydzik, Anna M; Flashman, Emily; McDonough, Michael A; Schofield, Christopher J; Brem, Jürgen

2016-10-01

Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibacterials including the latest generation carbapenems and are a growing worldwide clinical problem. It is proposed that MBLs employ one or two zinc ion cofactors in vivo. Isolated MBLs are reported to use transition metal ions other than zinc, including copper, cadmium and manganese, with iron ions being a notable exception. We report kinetic and biophysical studies with the di-iron(II)-substituted metallo-β-lactamase II from Bacillus cereus (di-Fe(II) BcII) and the clinically relevant B1 subclass Verona integron-encoded metallo-β-lactamase 2 (di-Fe(II) VIM-2). The results reveal that MBLs can employ ferrous iron in catalysis, but with altered kinetic and inhibition profiles compared to the zinc enzymes. A crystal structure of di-Fe(II) BcII reveals only small overall changes in the active site compared to the di-Zn(II) enzyme including retention of the di-metal bridging water; however, the positions of the metal ions are altered in the di-Fe(II) compared to the di-Zn(II) structure. Stopped-flow analyses reveal that the mechanism of nitrocefin hydrolysis by both di-Fe(II) BcII and di-Fe(II) VIM-2 is altered compared to the di-Zn(II) enzymes. Notably, given that the MBLs are the subject of current medicinal chemistry efforts, the results raise the possibility the Fe(II)-substituted MBLs may be of clinical relevance under conditions of low zinc availability, and reveal potential variation in inhibitor activity against the differently metallated MBLs. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Software Tools for Formal Specification and Verification of Distributed Real-Time Systems.

DTIC Science & Technology

1997-09-30

set of software tools for specification and verification of distributed real time systems using formal methods. The task of this SBIR Phase II effort...to be used by designers of real - time systems for early detection of errors. The mathematical complexity of formal specification and verification has

Definition of the Engineering Method.

ERIC Educational Resources Information Center

Koen, Billy Vaughn

In an effort to more clearly define the engineering method, this document attempts to draw distinctions between engineering and science. Part I, "Some Thoughts on Engineering," discusses strategies that engineers employ to solve problems, and the characteristics of the types of engineering problems. Part II, "The Principal Rule of the Engineering…

POLLUTION FROM THE COMBINED ACTIVITIES, ACTIONS ...

EPA Pesticide Factsheets

ORD's four-fold objectives in its efforts have been to: (i) Identify potential (future) environmental concerns (anticipatory research and identification of emerging issues, especially to identify pivotal sources of uncertainty that might affect risk estimates), (ii) Be proactive versus reactive (allowing for pollution prevention versus remediation/restoration; identify and foster investigation of

Managing pedestrian safety II : A case-control study of collision locations on state routes in King County and Seattle, Washington

DOT National Transportation Integrated Search

2008-01-01

The safety of non-motorized transportation systems is essential to the public acceptance and overall success of Washington State's and local jurisdictions' efforts to reduce congestion. The State's and the jurisdictions' goals to increase non-SOV (si...

LOW COST IMAGER FOR POLLUTANT GAS LEAK DETECTION - PHASE II

EPA Science Inventory

An inexpensive imaging Instrument to quickly locate leaks of methane and other greenhouse and VOC gases would reduce the cost and effort expended by industry to comply with EPA regulations. In Phase I, of this WBIR program, a new gas leak visualization camera was demonstrated...

FACTORS CONTRIBUTING TO FACULTY AND STUDENT ACCEPTANCE OF INSTRUCTIONAL TELEVISION, TEMP II.

ERIC Educational Resources Information Center

SANFORD, FILLMORE H.

PERTINENT FACTORS WERE DELINEATED IN THE ACCEPTANCE OR REJECTION OF TELEVISED INSTRUCTIONAL PROGRAMS USED WITH THE TEXAS EDUCATIONAL MICROWAVE PROJECT (TEMP)--AN EFFORT LINKING 11 COLLEGES AND UNIVERSITIES BY MICROWAVE TRANSMITTERS TO PROVIDE AN INTEGRATED CLOSED-CIRCUIT TELEVISION SYSTEM. DATA-GATHERING INSTRUMENTS WERE INTERVIEWS,…

Sensitivity and accuracy of high-throughput metabarcoding methods used to describe aquatic communities for early detection of invasve fish species

EPA Science Inventory

For early detection biomonitoring of aquatic invasive species, sensitivity to rare individuals and accurate, high-resolution taxonomic classification are critical to minimize Type I and II detection errors. Given the great expense and effort associated with morphological identifi...

Aging: Characteristics, Exposure Factors, Epigenetics, and Assessment of Health Risks of Older Adults

EPA Science Inventory

This chapter is organized into three sections. The first part describes the characteristics of the older adult population and the U.S. EPA’s efforts to protect elders form environmental hazards. Section II covers available exposure factor data, activity pattern and the pot...

Generic Competency Frameworks: A Brief Historical Overview

ERIC Educational Resources Information Center

Young, Jolee; Chapman, Elaine

2010-01-01

Significant efforts have now been made to identify the generic competencies required to succeed across different workplace contexts. The aims of this paper were to: (i) outline factors that contributed to the increased demand for generic competencies seen over the last three decades; and (ii) review the early generic competency frameworks…

Good Faith Efforts? Part II.

ERIC Educational Resources Information Center

Zirkel, Perry A.

2000-01-01

Regarding Catholic parents' suit against a suburban New York district for promoting occult activities, a federal court ruled in May 1999 that parents had failed to prove existence of the so- called Bedford program. This Solomon-like ruling also rejected First Amendment religious claims and 14th Amendment privacy claims. (MLH)

Atlas of NATO.

ERIC Educational Resources Information Center

Young, Harry F.

This atlas provides basic information about the North Atlantic Treaty Organization (NATO). Formed in response to growing concern for the security of Western Europe after World War II, NATO is a vehicle for Western efforts to reduce East-West tensions and the level of armaments. NATO promotes political and economic collaboration as well as military…

78 FR 23194 - Federal Acquisition Regulation; Commercial and Government Entity Code

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-18

... Award Management Name Change, Phase 1 Implementation) which will make a global update to all of the... outside the United States; and Support supply chain traceability and integrity efforts. II. Discussion and.... For Contractors registered in the System for Award Management (SAM), the DLA Logistics Information...

Impact of non-freeway rumble strips phase 1 : appendix II, example of run off the road left "target" crashes.

DOT National Transportation Integrated Search

2012-06-26

In an effort to reduce lane-departure crashes, in 2008 the Michigan Department of Transportation (MDOT) began a three-year statewide non-freeway rumble strip installation initiative. This initiative called for the installation of milled centerline ru...

Afghanistan: Green-on-Blue Attacks

DTIC Science & Technology

2013-05-02

burnt copies of the Quran in a garbage dump at Bagram Air Base that sparked several days of anti-American riots in February 2012. An Afghan soldier...reaching a Category II or III threat. A concerted effort between the Afghan government and military and the Coalition lead to several concrete measures

50 CFR 18.118 - What are the mitigation, monitoring, and reporting requirements?

Code of Federal Regulations, 2014 CFR

2014-10-01

... monitoring and research efforts will employ rigorous study designs and sampling protocols in order to provide... mitigation measures for offshore seismic surveys. Any offshore exploration activity expected to include the... 1 µPa. (ii) Ramp-up procedures. For all seismic surveys, including airgun testing, use the following...

50 CFR 18.118 - What are the mitigation, monitoring, and reporting requirements?

Code of Federal Regulations, 2013 CFR

2013-10-01

... monitoring and research efforts will employ rigorous study designs and sampling protocols in order to provide... mitigation measures for offshore seismic surveys. Any offshore exploration activity expected to include the... 1 µPa. (ii) Ramp-up procedures. For all seismic surveys, including airgun testing, use the following...

20 CFR 628.325 - Incentive grants, capacity building, and technical assistance.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., exceeding title II performance standards (section 106(b)(7)). (2) Incentive grant funds under this section... give consideration to recognizing the performance of service providers within the State. (5) SDA's... capacity building and technical assistance efforts aimed at improving the competencies of the personnel who...

Law, Morality and the Relocation Camps.

ERIC Educational Resources Information Center

Stearns, Hal

1990-01-01

Presents a lesson examining the historical background of the U.S. government's relocation and internment of Japanese-Americans and Japanese aliens during World War II. Asks secondary students to consider both the legal and moral dimensions of the relocation effort and current compensation arguments. Includes handouts and suggestions for role…

Team effort: the nuclear medicine decision making process. Part II.

PubMed

Tsuchiyama, S

1991-06-01

This two part article examines the nuclear medicine purchase of Baptist Memorial Hospital in Memphis, the largest private hospital in the nation. Part I (May 1991) focused on what their needs were. This concluding installment looks at the committee mechanism itself and the reasoning that went behind their decisions.

Sperm competition games when males invest in paternal care.

PubMed

Requena, Gustavo S; Alonzo, Suzanne H

2017-08-16

Sperm competition games investigate how males partition limited resources between pre- and post-copulatory competition. Although extensive research has explored how various aspects of mating systems affect this allocation, male allocation between mating, fertilization and parental effort has not previously been considered. Yet, paternal care can be energetically expensive and males are generally predicted to adjust their parental effort in response to expected paternity. Here, we incorporate parental effort into sperm competition games, particularly exploring how the relationship between paternal care and offspring survival affects sperm competition and the relationship between paternity and paternal care. Our results support existing expectations that (i) fertilization effort should increase with female promiscuity and (ii) paternal care should increase with expected paternity. However, our analyses also reveal that the cost of male care can drive the strength of these patterns. When paternal behaviour is energetically costly, increased allocation to parental effort constrains allocation to fertilization effort. As paternal care becomes less costly, the association between paternity and paternal care weakens and may even be absent. By explicitly considering variation in sperm competition and the cost of male care, our model provides an integrative framework for predicting the interaction between paternal care and patterns of paternity. © 2017 The Author(s).