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Sample records for ii dihydroxybenzenes aminophenols

  1. Dioxygen Reactivity of Biomimetic Fe(II) Complexes with Noninnocent Catecholate, o-Aminophenolate, and o-Phenylenediamine Ligands

    PubMed Central

    2015-01-01

    This study describes the O2 reactivity of a series of high-spin mononuclear Fe(II) complexes each containing the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (Ph2TIP) ligand and one of the following bidentate, redox-active ligands: 4-tert-butylcatecholate (tBuCatH–), 4,6-di-tert-butyl-2-aminophenolate (tBu2APH–), or 4-tert-butyl-1,2-phenylenediamine (tBuPDA). The preparation and X-ray structural characterization of [Fe2+(Ph2TIP)(tBuCatH)]OTf, [3]OTf and [Fe2+(Ph2TIP)(tBuPDA)](OTf)2, [4](OTf)2 are described here, whereas [Fe2+(Ph2TIP)(tBu2APH)]OTf, [2]OTf was reported in our previous paper [Bittner et al., Chem.—Eur. J.2013,19, 9686–9698]. These complexes mimic the substrate-bound active sites of nonheme iron dioxygenases, which catalyze the oxidative ring-cleavage of aromatic substrates like catechols and aminophenols. Each complex is oxidized in the presence of O2, and the geometric and electronic structures of the resulting complexes were examined with spectroscopic (absorption, EPR, Mössbauer, resonance Raman) and density functional theory (DFT) methods. Complex [3]OTf reacts rapidly with O2 to yield the ferric-catecholate species [Fe3+(Ph2TIP)(tBuCat)]+ (3ox), which undergoes further oxidation to generate an extradiol cleavage product. In contrast, complex [4]2+ experiences a two-electron (2e–), ligand-based oxidation to give [Fe2+(Ph2TIP)(tBuDIBQ)]2+ (4ox), where DIBQ is o-diiminobenzoquinone. The reaction of [2]+ with O2 is also a 2e– process, yet in this case both the Fe center and tBu2AP ligand are oxidized; the resulting complex (2ox) is best described as [Fe3+(Ph2TIP)(tBu2ISQ)]+, where ISQ is o-iminobenzosemiquinone. Thus, the oxidized complexes display a remarkable continuum of electronic structures ranging from [Fe3+(L2–)]+ (3ox) to [Fe3+(L•–)]2+ (2ox) to [Fe2+(L0)]2+ (4ox). Notably, the O2 reaction rates vary by a factor of 105 across the series, following the order [3]+ > [2]+ > [4]2+, even though the

  2. A family of 13 tetranuclear zinc(II)-lanthanide(III) complexes of a [3+3] Schiff-base macrocycle derived from 1,4-diformyl-2,3-dihydroxybenzene.

    PubMed

    Feltham, Humphrey L C; Klöwer, Frederik; Cameron, Scott A; Larsen, David S; Lan, Yanhua; Tropiano, Manuel; Faulkner, Stephen; Powell, Annie K; Brooker, Sally

    2011-11-21

    A family of thirteen tetranuclear heterometallic zinc(II)-lanthanide(III) complexes of the hexa-imine macrocycle (L(Pr))(6-), with general formula Zn(II)(3)Ln(III)(L(Pr))(NO(3))(3)·xsolvents (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm or Yb), were prepared in a one-pot synthesis using a 3:1:3:3 reaction of zinc(II) acetate, the appropriate lanthanide(III) nitrate, the dialdehyde 1,4-diformyl-2,3-dihydroxybenzene (H(2)L(1)) and 1,3-diaminopropane. A hexanuclear homometallic zinc(II) macrocyclic complex [Zn(6)(L(Pr))(OAc)(5)(OH)(H(2)O)]·3H(2)O was obtained using a 2:0:1:1 ratio of the same reagents. A control experiment using a 1:0:1:1 ratio failed to generate the lanthanide-free [Zn(3)(L(Pr))] macrocyclic complex. The reaction of H(2)L(1) and zinc(II) acetate in a 1:1 ratio yielded the pentanuclear homometallic complex of the dialdehyde H(2)L(1), [Zn(5)(L(1))(5)(H(2)O)(6)]·3H(2)O. An X-ray crystal structure determination revealed [Zn(3)(II)Pr(III)(L(Pr))(NO(3))(2)(DMF)(3)](NO(3))·0.9DMF has the large ten-coordinate lanthanide(III) ion bound in the central O(6) site with two bidentate nitrate anions completing the O(10) coordination sphere. The three square pyramidal zinc(II) ions are in the outer N(2)O(2) sites with a fifth donor from DMF. Measurement of the magnetic properties of [Zn(II)(3)Dy(III)(L(Pr))(NO(3))(3)(MeOH)(3)]·4H(2)O with a weak external dc field showed that it has a frequency-dependent out-of-phase component of ac susceptibility, indicative of slow relaxation of the magnetization (SMM behaviour). Likewise, the Er and Yb analogues are field-induced SMMs; the latter is only the second example of a Yb-based SMM. The neodymium, ytterbium and erbium complexes are luminescent in the solid phase, but only the ytterbium and neodymium complexes show strong lanthanide-centred luminescence in DMF solution.

  3. Copper(II) complex of new non-innocent O-aminophenol-based ligand as biomimetic model for galactose oxidase enzyme in aerobic oxidation of alcohols

    NASA Astrophysics Data System (ADS)

    Safaei, Elham; Bahrami, Hadiseh; Pevec, Andrej; Kozlevčar, Bojan; Jagličić, Zvonko

    2017-04-01

    Mononuclear copper(II) complex of tetra-dentate o-aminophenol-based ligand (H2LBAPP) has been synthesized and characterized. The three dentate precursor (HLBAP) of the final ligand was synthesized first, while the title four-dentate copper bound ligand was synthesized in situ, isolated only in the final copper species [CuLBAPP]. This copper coordination complex reveals a distorted square-planar geometry around the copper(II) centre by one oxygen and three nitrogen atoms from the coordinating ligand. The ligand is thus twice deprotonated via hydroxy and amine groups. The complex is red, non-typical for copper(II), but the effective magnetic moment of 1.86 B M. and a single isotropic symmetry EPR signal with g 2.059 confirm a S = 1/2 diluted spin system, without copper-copper magnetic coupling. Electrochemical oxidation of this complex yields the corresponding Cu(II)-phenyl radical species. Finally, the title complex CuLBAPP has shown good and selective catalytic activity towards alcohol to aldehyde oxidation, at aerobic room temperature conditions, for a set of different alcohols.

  4. Synthesis, structural characterization, thermal studies, catalytic efficiency and antimicrobial activity of some M(II) complexes with ONO tridentate Schiff base N-salicylidene-o-aminophenol (saphH2)

    NASA Astrophysics Data System (ADS)

    Abdel Aziz, Ayman A.; Salem, Abdel Naby M.; Sayed, Mostafa A.; Aboaly, Mohamed M.

    2012-02-01

    The reactions of acetate salts of M(II) (M = Mn, Co, Ni, Cu and Zn) with N-salicylidene-o-aminophenol (saphH2) in ethyl alcohol afforded new four coordinated complexes with the general formula [M(II)(saph)(H2O)]. The complexes have been fully characterized by microanalysis, molar conductance, magnetic susceptibility, 1H NMR, IR, UV-Vis, ESR, mass spectra and thermogravimetric analysis (TGA). The experimental data have been shown that all complexes are mononuclear with the M(II) being coordinated by a dianionic tridentate Schiff base ligand, through the deprotonated two enolic oxygen and the azomethine nitrogen atoms. UV-Vis spectra and magnetic moments have been suggested square planar stereochemistry for Co(II) and Cu(II) complexes, and tetrahedral geometry has been suggested for Mn(II), Ni(II) and Zn(II) complexes. The new complexes have been tested for their abilities to catalyze aerial oxidation of benzaldehyde to benzoic acid. Finally, in view of the biological activity, antibacterial and antifungal tests of the ligand and its complexes have been carried out and the results were compared with some known antibiotics.

  5. In situ Oxidation of phenol and o-aminophenol in the channels of 3d-supramolecular coordination polymers

    NASA Astrophysics Data System (ADS)

    Etaiw, Safaa El-Din H.; Werida, Amal H.

    2010-09-01

    The host attractive properties of supramolecular coordination polymers of the type _infty^3 [(R3Sn)3FeIII(CN)6], where R = methyl (I), n-butyl (II), and phenyl (III), afford the ability to be used as effective oxidizing reagents for phenol and o-aminophenol forming new host-guest supramolecular coordination polymers. Phenol was oxidized to 1,4-benzoquinone while o-aminophenol was oxidized to poly-o-aminophenol by the polymers I and II and to 2-aminophenoxazin-3-one by the polymer III. The oxidation products were investigated by methods of spectroscopy and high-performance liquid chromatography. The redox reactions were characterized by first-order kinetics. Moreover, mechanisms of the oxidation processes of phenol and o-aminophenol have been proposed.

  6. Horseradish peroxidase immobilized on copper surfaces and applications in selective electrocatalysis of p-dihydroxybenzene

    NASA Astrophysics Data System (ADS)

    Wang, Chuntao; Luo, Xiaoxiao; Jia, Zehui; Shi, Qinghua; Zhu, Ritao

    2017-06-01

    Horseradish Peroxidase (HRP) was immobilized on copper surfaces with the linker of L-Cysteine (L-Cys) self-assembled films to form Cu/L-Cys/HRP electrodes. The activity of HRP can be preserved by the Cu/L-Cys self-assembled films. The Cu/L-Cys/HRP electrodes can be used for the selective electrocatalytic oxidase of p-dihydroxybenzen in absent of H2O2. The optimum pH for electrocatalyzing p-dihydroxybenzen was 5.5 or 7.0, which corresponds to the isoelectric points of L-Cys and HRP, respectively. X-ray photoelectron spectroscopy (XPS) provided the evidence that L-Cys linked with Cu surface by the Cusbnd S bond. Fourier transform infrared spectroscopy (FTIR) analyses indicated that aromatic plane of p-dihydroxybenzen was connected parallel to porphyrin ring of heme in HRP. Quantum chemical calculation of density functional theory (DFT) revealed that symmetry of molecular structure and minimum space steric hindrance for p-dihydroxybenzen were benefit to combination with HRP. Moreover, the lowest energy of LUMO and most negative charges of oxygen atom on hydroxyl group of p-dihydroxybenzen were advantage to lose the hydrogen atom of hydroxyl group to be oxided.

  7. Separate determination of nitrophenols and aminophenols in aqueous solutions

    SciTech Connect

    Korenman, Y.I.; Bortnikova, R.N.; Nefedova, T.A.; Sotnikova, N.G.

    1985-05-01

    Nitro and aminophenols are widely distributed, highly toxic components of waste waters from the phenolic industry. This article proposes a rapid extraction photometric method for determination of the most widespread isomers of nitro and aminophenols (ortho-substituted). Preliminary separation of the components being determined is based on the substantial difference in the ability of 2-nitrophenol and 2-aminophenol to be extracted from aqueous solutions by organic solvents. It is shown that the distribution coefficient for 2-nitrophenol in the system dibutyl ether-water is almost 40 times larger than the corresponding value for 2-aminophenol. The method described made possible the determination of 2-nitrophenol and 2-aminophenol in aqueous solution after their separation with satisfactory accuracy. The maximum error for the determination of 2-aminophenol was 12% and for 2-nitrophenol, 4%.

  8. Adsorption and coupling of 4-aminophenol on Pt(111) surfaces

    NASA Astrophysics Data System (ADS)

    Otero-Irurueta, G.; Martínez, J. I.; Bueno, R. A.; Palomares, F. J.; Salavagione, H. J.; Singh, M. K.; Méndez, J.; Ellis, G. J.; López, M. F.; Martín-Gago, J. A.

    2016-04-01

    We have deposited 4-aminophenol on Pt(111) surfaces in ultra-high vacuum and studied the strength of its adsorption through a combination of STM, LEED, XPS and ab initio calculations. Although an ordered (2√3 × 2√3)R30° phase appears, we have observed that molecule-substrate interaction dominates the adsorption geometry and properties of the system. At RT the high catalytic activity of Pt induces aminophenol to lose the H atom from the hydroxyl group, and a proportion of the molecules lose the complete hydroxyl group. After annealing above 420 K, all deposited aminophenol molecules have lost the OH moiety and some hydrogen atoms from the amino groups. At this temperature, short single-molecule oligomer chains can be observed. These chains are the product of a new reaction that proceeds via the coupling of radical species that is favored by surface diffusion.

  9. Adsorption and Coupling of 4-aminophenol on Pt(111) surfaces.

    PubMed

    Otero-Irurueta, G; Martínez, J I; Bueno, R A; Palomares, F J; Salavagione, H J; Singh, M K; Méndez, J; Ellis, G J; López, M F; Martín-Gago, J A

    2015-09-06

    We have deposited 4-aminophenol on Pt(111) surfaces in ultra-high vacuum and studied the strength of its adsorption through a combination of STM, LEED, XPS and ab initio calculations. Although an ordered (2√3×2√3)R30° phase appears, we have observed that molecule-substrate interaction dominates the adsorption geometry and properties of the system. At RT the high catalytic activity of Pt induces aminophenol to lose the H atom from the hydroxyl group, and a proportion of the molecules lose the complete hydroxyl group. After annealing above 420K, all deposited aminophenol molecules have lost the OH moiety and some hydrogen atoms from the amino groups. At this temperature, short single-molecule oligomer chains can be observed. These chains are the product of a new reaction that proceeds via the coupling of radical species that is favoured by surface diffusion.

  10. Adsorption and Coupling of 4-aminophenol on Pt(111) surfaces

    PubMed Central

    Otero-Irurueta, G.; Martínez, J. I.; Bueno, R.A.; Palomares, F. J.; Salavagione, H. J.; Singh, M. K.; Méndez, J.; Ellis, G. J.; López, M. F.; Martín-Gago, J. A.

    2016-01-01

    We have deposited 4-aminophenol on Pt(111) surfaces in ultra-high vacuum and studied the strength of its adsorption through a combination of STM, LEED, XPS and ab initio calculations. Although an ordered (2√3×2√3)R30° phase appears, we have observed that molecule-substrate interaction dominates the adsorption geometry and properties of the system. At RT the high catalytic activity of Pt induces aminophenol to lose the H atom from the hydroxyl group, and a proportion of the molecules lose the complete hydroxyl group. After annealing above 420K, all deposited aminophenol molecules have lost the OH moiety and some hydrogen atoms from the amino groups. At this temperature, short single-molecule oligomer chains can be observed. These chains are the product of a new reaction that proceeds via the coupling of radical species that is favoured by surface diffusion. PMID:27279673

  11. Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes

    DOEpatents

    Hammond, Peter R.

    1986-01-01

    Methods are provided for making certain m-aminophenols using a sulfonation/alkali fusion procedure. The aminophenols are key intermediates in the synthesis of dyes, particularly efficient, stable dyes for laser application. Preparations of some rhodamine and phenoxazone dyes from the m-aminophenols are described.

  12. Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes

    DOEpatents

    Hammond, P.R.

    1983-12-29

    Methods are provided for making certain m-aminophenols using a sulfonation/alkali fusion procedure. The aminophenols are key intermediates in the synthesis of dyes, particularly efficient, stable dyes for laser application. Preparations of some rhodamine and phenoxazone dyes from the m-aminophenols are described.

  13. High sensitivity Schottky junction diode based on monolithically grown aligned polypyrrole nanofibers: Broad range detection of m-dihydroxybenzene.

    PubMed

    Ameen, Sadia; Akhtar, M Shaheer; Seo, Hyung-Kee; Shin, Hyung Shik

    2015-07-30

    Aligned p-type polypyrrole (PPy) nanofibers (NFs) thin film was grown on n-type silicon (100) substrate by an electrochemical technique to fabricate Schottky junction diode for the efficient detection of m-dihydroxybenzene chemical. The highly dense and well aligned PPy NFs with the average diameter (∼150-200 nm) were grown on n-type Si substrate. The formation of aligned PPy NFs was confirmed by elucidating the structural, compositional and the optical properties. The electrochemical behavior of the fabricated Pt/p-aligned PPy NFs/n-silicon Schottky junction diode was evaluated by cyclovoltametry (CV) and current (I)-voltage (V) measurements with the variation of m-dihydroxybenzene concentration in the phosphate buffer solution (PBS). The fabricated Pt/p-aligned PPy NFs/n-silicon Schottky junction diode exhibited the rectifying behavior of I-V curve with the addition of m-dihydroxybenzene chemical, while a weak rectifying I-V behavior was observed without m-dihydroxybenzene chemical. This non-linear I-V behavior suggested the formation of Schottky barrier at the interface of Pt layer and p-aligned PPy NFs/n-silicon thin film layer. By analyzing the I-V characteristics, the fabricated Pt/p-aligned PPy NFs/n-silicon Schottky junction diode displayed reasonably high sensitivity ∼23.67 μAmM(-1)cm(-2), good detection limit of ∼1.51 mM with correlation coefficient (R) of ∼0.9966 and short response time (10 s).

  14. Ozonation of 1,2-dihydroxybenzene in the presence of activated carbon.

    PubMed

    Zaror, C; Soto, G; Valdés, H; Mansilla, H

    2001-01-01

    This work aims at obtaining experimental data on ozonation of 1,2-dihydroxybenzene (DHB) in the presence of activated carbon, with a view to assessing possible changes in its surface chemical structure and adsorption capacity. Experiments were conducted in a 0.5 L reactor, loaded with 2 g Filtrasorb 400 granular activated carbon, and 1-5 mM DHB aqueous solution at pH 2-8. Ozone gas was generated with an Ozocav generator, and fed into the reactor for a given exposure time, in the range 0.5-240 min, at 25 degrees C and 1 atm. After each run, liquid and activated carbon samples were taken for chemical assays. Soluble organic groups present on the active carbon surface were desorbed and analysed by GC-MS and HPLC. Activated carbon chemical surface properties were analysed using TPD, FT-IR, and XPS techniques. Reactions between ozone and adsorbed DHB were shown to be fast, leading to formation of C-6, C-4 and C-2 by-products. Oxygenated surface groups, particularly, COOH and C = O, increased as a result of ozonation.

  15. Dehydrogenation of anhydrous methanol at room temperature by o-aminophenol-based photocatalysts

    PubMed Central

    Wakizaka, Masanori; Matsumoto, Takeshi; Tanaka, Ryota; Chang, Ho-Chol

    2016-01-01

    Dehydrogenation of anhydrous methanol is of great importance, given its ubiquity as an intermediate for the production of a large number of industrial chemicals. Since dehydrogenation of methanol is an endothermic reaction, heterogeneous or homogeneous precious-metal-based catalysts and high temperatures are usually required for this reaction to proceed. Here we report the photochemical dehydrogenation of anhydrous methanol at room temperature catalysed by o-aminophenol (apH2), o-aminophenolate (apH−) and the non-precious metal complex trans-[FeII(apH)2(MeOH)2]. Under excitation at 289±10 nm and in the absence of additional photosensitizers, these photocatalysts generate hydrogen and formaldehyde from anhydrous methanol with external quantum yields of 2.9±0.15%, 3.7±0.19% and 4.8±0.24%, respectively, which are the highest values reported so far to the best of our knowledge. Mechanistic investigations reveal that the photo-induced formation of hydrogen radicals triggers the reaction. PMID:27457731

  16. N-Acetyl-4-aminophenol (paracetamol), N-acetyl-2-aminophenol and acetanilide in urine samples from the general population, individuals exposed to aniline and paracetamol users.

    PubMed

    Dierkes, Georg; Weiss, Tobias; Modick, Hendrik; Käfferlein, Heiko Udo; Brüning, Thomas; Koch, Holger M

    2014-01-01

    Epidemiological studies suggest associations between the use of N-acetyl-4-aminophenol (paracetamol) during pregnancy and increased risks of reproductive disorders in the male offspring. Previously we have reported a ubiquitous urinary excretion of N-acetyl-4-aminophenol in the general population. Possible sources are (1) direct intake of paracetamol through medication, (2) paracetamol residues in the food chain and (3) environmental exposure to aniline or related substances that are metabolized into N-acetyl-4-aminophenol. In order to elucidate the origins of the excretion of N-acetyl-4-aminophenol in urine and to contribute to the understanding of paracetamol and aniline metabolism in humans we developed a rapid, turbulent-flow HPLC-MS/MS method with isotope dilution for the simultaneous quantification of N-acetyl-4-aminophenol and two other aniline related metabolites, N-acetyl-2-aminophenol and acetanilide. We applied this method to three sets of urine samples: (1) individuals with no known exposure to aniline and also no recent paracetamol medication; (2) individuals after occupational exposure to aniline but no paracetamol medication and (3) paracetamol users. We confirmed the omnipresent excretion of N-acetyl-4-aminophenol. Additionally we revealed an omnipresent excretion of N-acetyl-2-aminophenol. In contrast, acetanilide was only found after occupational exposure to aniline, not in the general population or after paracetamol use. The results lead to four preliminary conclusions: (1) other sources than aniline seem to be responsible for the major part of urinary N-acetyl-4-aminophenol in the general population; (2) acetanilide is a metabolite of aniline in man and a valuable biomarker for aniline in occupational settings; (3) aniline baseline levels in the general population measured after chemical hydrolysis do not seem to originate from acetanilide and hence not from a direct exposure to aniline itself and (4) N-acetyl-2-aminophenol does not seem to be

  17. [Simultaneous determination of 11 aminophenols in hair dyes by high performance liquid chromatography].

    PubMed

    Zhu, Weixia; Wang, Caijuan; Yang, Jizhou; Wei, Wei; Sun, Zhuanlian; Zhang, Shusheng

    2012-09-01

    An analytical method was developed for the simultaneous determination of 11 aminophenols in direct and oxidized hair dyes by high performance liquid chromatography (HPLC). The samples were extracted with methanol using sodium bisulfite for anti-oxidation. The purification was carried out with the high speed frozen centrifugation. The separation was performed on an Agilent Zorbax SB C18 column with the mobile phases of acetonitrile and an ion pair system of sodium heptanesulfonate and phosphate under a gradient elution. The analytes were detected at three different wavelengths of 230, 270 and 400 nm. In the concentration range of 0.05 - 500 mg/L, the correlation coefficients for the 11 aminophenols were not less than 0.9992. The limits of quantification including 4-amino-3-nitrophenol, 2-amino-5-nitrophenol, and 4-(2-hydroxyethyl) amino-3-nitrophenol were 5 mg/kg. Other aminophenols including 4-aminophenol, 4-methyl aminophenol, 3-aminophenol, 2-aminophenol, 5-amino-o-cresol, 4-amino-3-methylphenol, 5-(2-hydroxyethyl) amino-o-cresol and 2-amino-4-nitrophenol were 20 mg/kg. The recoveries of the aminophenols spiked at different levels ranged from 88.5% to 109. 5% with the relative standard deviations (RSDs) within the range of 2.2% - 8.3%. The commercially available hair dye samples were analyzed for the aminophenols and the results showed that the method was suitable for the determination of the 11 aminophenols in direct and oxidized hair dyes.

  18. 40 CFR 721.5840 - Ethylated aminophenol.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section. (2) The significant new uses are: (i) Protection in the workplace. Requirements as specified in § 721.63 (a)(1) and (a)(3). (ii) Hazard communication program. Requirements as specified in § 721.72...

  19. 40 CFR 721.5820 - Aminophenol.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Protection in the workplace. Requirements as specified in § 721.63 (a)(1) and (a)(3). (ii) Hazard communication program. Requirements as specified in § 721.72 (b)(1)(i)(D) and (g)(2)(v). The provision of §...

  20. Interaction of o-aminophenol and o-nitrophenol with copper, zinc, molybdenum, and chromium ferrocyanides

    SciTech Connect

    Tewari, B.B.; Kamaluddin

    1997-09-15

    Removal of o-aminophenol and o-nitrophenol from aqueous solution through adsorption on copper, zinc, molybdenum, and chromium ferrocyanides were studied in pH range 2--10 at 27 C. At pH 7.0 o-nitrophenol adsorbed more than o-aminophenol on all the metal ferrocyanides studied. The Langmuir type of adsorption is followed in the concentration range of 10{sup {minus}3} to 10{sup {minus}4} M of o-aminophenol and o-nitrophenol solutions.

  1. Terahertz wave reference-free transmission spectroscopy of aminophenol

    NASA Astrophysics Data System (ADS)

    Deng, Chao; Zhong, Hua; Zhang, Liangliang; Zhang, Cunlin

    2008-12-01

    We present a reference-free transmission spectroscopy of two kinds of aminophenol (Tyrosine and Phenylalanine) using terahertz time domain spectroscopy (THz-TDS). The THz band, which refers to the spectral region between 0.1 to 10 THz, offers a plethora of fingerprints of many chemical and biological materials. Within the past few years, efforts have been focused on exploiting the broadband nature of the THz time domain spectroscopy (THz-TDS) system for material identification and characterization. The conventional spectroscopic sensing method involves measuring both the terahertz signal carrying the sample information and a reference terahertz signal. In transmission geometry measurement, the absorption peaks of the sample material are found by taking the logarithm of the power spectrum of the transmitted signal beam divided by a reference power spectrum. In this work, we propose a reference-free approach to extract the absorption feature in THz transmission spectroscopy. The samples are identified by their absorption peaks extracted from the negative first-order derivative of the sample signal phase divided by the frequency. Unlike in conventional transmission spectroscopy measurement, in this method, the amplitude spectrum of the terahertz signal is not considered at all. Instead, the absorption features are extracted exclusively from the phase information by taking advantage of the almost-linear phase spectrum of terahertz pulses and the correlation between dispersion and absorption. It is also noted that the spectral phase of the terahertz pulse can be determined with far greater accuracy than the amplitude, which makes this method even more favorable. We measured two kinds of aminophenol (Tyrosine and Phenylalanine), and calculated the absorbance spectrum of each by both methods: taking the ratio between the power spectra of the sample signal and the reference signal and the reference-free phase spectrum of each material. The agreement between the positions

  2. 40 CFR 721.5286 - Benzenediazonium, [[[[(substituted) azo]phenyl]sulfonyl]amino]-, coupled with aminophenol...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...]amino]-, coupled with aminophenol, diazotized aminobenzoic acid, diazotized (substituted) benzenesulfonic acid and naphthalenol (generic). 721.5286 Section 721.5286 Protection of Environment ENVIRONMENTAL... Significant New Uses for Specific Chemical Substances § 721.5286 Benzenediazonium,...

  3. 40 CFR 721.5286 - Benzenediazonium, [[[[(substituted) azo]phenyl]sulfonyl]amino]-, coupled with aminophenol...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...]amino]-, coupled with aminophenol, diazotized aminobenzoic acid, diazotized (substituted) benzenesulfonic acid and naphthalenol (generic). 721.5286 Section 721.5286 Protection of Environment ENVIRONMENTAL... Significant New Uses for Specific Chemical Substances § 721.5286 Benzenediazonium,...

  4. 40 CFR 721.5286 - Benzenediazonium, [[[[(substituted) azo]phenyl]sulfonyl]amino]-, coupled with aminophenol...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...]amino]-, coupled with aminophenol, diazotized aminobenzoic acid, diazotized (substituted) benzenesulfonic acid and naphthalenol (generic). 721.5286 Section 721.5286 Protection of Environment ENVIRONMENTAL... Significant New Uses for Specific Chemical Substances § 721.5286 Benzenediazonium,...

  5. 40 CFR 721.5286 - Benzenediazonium, [[[[(substituted) azo]phenyl]sulfonyl]amino]-, coupled with aminophenol...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...]amino]-, coupled with aminophenol, diazotized aminobenzoic acid, diazotized (substituted) benzenesulfonic acid and naphthalenol (generic). 721.5286 Section 721.5286 Protection of Environment ENVIRONMENTAL... Significant New Uses for Specific Chemical Substances § 721.5286 Benzenediazonium,...

  6. 40 CFR 721.5286 - Benzenediazonium, [[[[(substituted) azo]phenyl]sulfonyl]amino]-, coupled with aminophenol...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...]amino]-, coupled with aminophenol, diazotized aminobenzoic acid, diazotized (substituted) benzenesulfonic acid and naphthalenol (generic). 721.5286 Section 721.5286 Protection of Environment ENVIRONMENTAL... Significant New Uses for Specific Chemical Substances § 721.5286 Benzenediazonium,...

  7. Fact Sheets: Air Toxics Rules for the Manufacture of Amino/Phenolic Resins

    EPA Pesticide Factsheets

    This page contains a December 1999 fact sheet for the proposed National Emission Standards for Hazardous Air Pollutants (NESHAP): Manufacture of Amino/Phenolic Resins and a September 2014 fact sheet with information regarding the final NESHAP

  8. N-terminal modification of proteins with o-aminophenols.

    PubMed

    Obermeyer, Allie C; Jarman, John B; Francis, Matthew B

    2014-07-09

    The synthetic modification of proteins plays an important role in chemical biology and biomaterials science. These fields provide a constant need for chemical tools that can introduce new functionality in specific locations on protein surfaces. In this work, an oxidative strategy is demonstrated for the efficient modification of N-terminal residues on peptides and N-terminal proline residues on proteins. The strategy uses o-aminophenols or o-catechols that are oxidized to active coupling species in situ using potassium ferricyanide. Peptide screening results have revealed that many N-terminal amino acids can participate in this reaction, and that proline residues are particularly reactive. When applied to protein substrates, the reaction shows a stronger requirement for the proline group. Key advantages of the reaction include its fast second-order kinetics and ability to achieve site-selective modification in a single step using low concentrations of reagent. Although free cysteines are also modified by the coupling reaction, they can be protected through disulfide formation and then liberated after N-terminal coupling is complete. This allows access to doubly functionalized bioconjugates that can be difficult to access using other methods.

  9. Construction of Escherichia coli Strains for Conversion of Nitroacetophenones to ortho-Aminophenols

    PubMed Central

    Kadiyala, Venkateswarlu; Nadeau, Lloyd J.; Spain, Jim C.

    2003-01-01

    The predominant bacterial pathway for nitrobenzene (NB) degradation uses an NB nitroreductase and hydroxylaminobenzene (HAB) mutase to form the ring-fission substrate ortho-aminophenol. We tested the hypothesis that constructed strains might accumulate the aminophenols from nitroacetophenones and other nitroaromatic compounds. We constructed a recombinant plasmid carrying NB nitroreductase (nbzA) and HAB mutase A (habA) genes, both from Pseudomonas pseudoalcaligenes JS45, and expressed the enzymes in Escherichia coli JS995. IPTG (isopropyl-β-d-thiogalactopyranoside)-induced cells of strain JS995 rapidly and stoichiometrically converted NB to 2-aminophenol, 2-nitroacetophenone (2NAP) to 2-amino-3-hydroxyacetophenone (2AHAP), and 3-nitroacetophenone (3NAP) to 3-amino-2-hydroxyacetophenone (3AHAP). We constructed another recombinant plasmid containing the nitroreductase gene (nfs1) from Enterobacter cloacae and habA from strain JS45 and expressed the enzymes in E. coli JS996. Strain JS996 converted NB to 2-aminophenol, 2-nitrotoluene to 2-amino-3-methylphenol, 3-nitrotoluene to 2-amino-4-methylphenol, 4-nitrobiphenyl ether to 4-amino-5-phenoxyphenol, and 1-nitronaphthalene to 2-amino-1-naphthol. In larger-scale biotransformations catalyzed by strain JS995, 75% of the 2NAP transformed was converted to 2AHAP, whereas 3AHAP was produced stoichiometrically from 3NAP. The final yields of the aminophenols after extraction and recovery were >64%. The biocatalytic synthesis of ortho-aminophenols from nitroacetophenones suggests that strain JS995 may be useful in the biocatalytic production of a variety of substituted ortho-aminophenols from the corresponding nitroaromatic compounds.   PMID:14602609

  10. Structures and vibrations of neutral and cationic 3- and 4-aminophenol

    NASA Astrophysics Data System (ADS)

    Unterberg, C.; Gerlach, A.; Jansen, A.; Gerhards, M.

    2004-10-01

    A combined experimental and theoretical study on the structures and vibrations of 3- and 4-aminophenol in their neutral and ionic ground states is presented. The vibrations of the two possible isomers of 3-aminophenol and the one isomer of 4-aminophenol are investigated by mass analyzed threshold ionization (MATI) spectroscopy in the ionic ground state and by infrared resonant 2-photon ionization (IR/R2PI) spectroscopy in the neutral ground state. The experimentally observed vibrational frequencies of all isomers are in excellent agreement with the calculated values obtained by density functional theory (DFT) and at the complete active space self-consistent field (CASSCF) level of theory. The calculations support the assignment of different isomers. Furthermore, the experimentally observed ionization potentials are well predicted by CASMP2//CASSCF calculations.

  11. 40 CFR Table 2 to Subpart Ooo of... - Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (HAP) From the Manufacture of Amino/Phenolic Resins 2 Table 2 to Subpart OOO of Part 63 Protection of... Pollutant Emissions: Manufacture of Amino/Phenolic Resins Pt. 63, Subpt. OOO, Table 2 Table 2 to Subpart OOO of Part 63—Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic...

  12. 40 CFR Table 2 to Subpart Ooo of... - Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (HAP) From the Manufacture of Amino/Phenolic Resins 2 Table 2 to Subpart OOO of Part 63 Protection of... Pollutant Emissions: Manufacture of Amino/Phenolic Resins Pt. 63, Subpt. OOO, Table 2 Table 2 to Subpart OOO of Part 63—Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic...

  13. 40 CFR Table 2 to Subpart Ooo of... - Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (HAP) From the Manufacture of Amino/Phenolic Resins 2 Table 2 to Subpart OOO of Part 63 Protection of... Pollutant Emissions: Manufacture of Amino/Phenolic Resins Pt. 63, Subpt. OOO, Table 2 Table 2 to Subpart OOO of Part 63—Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic...

  14. Orthogonal Cu- and Pd-Based Catalyst Systems for the O- and N-Arylation of Aminophenols

    PubMed Central

    Maiti, Debabrata; Buchwald, Stephen L.

    2009-01-01

    O- or N-arylated aminophenol products constitute a common structural motif in various potentially useful therapeutic agents and/or drug candidates. We have developed a complementary set of Cu- and Pd-based catalyst systems for the selective O- and N-arylation of unprotected aminophenols using aryl halides. Selective O-arylation of 3- and 4-aminophenols is achieved with copper-catalyzed methods employing picolinic acid or CyDMEDA, trans-N,N′-dimethyl-1,2-cyclohexanediamine, respectively, as the ligand. The selective formation of N-arylated products of 3- and 4-aminophenols can be obtained with BrettPhos precatalyst, a biarylmonophosphine-based palladium catalyst. 2-Aminophenol can be selectively N-arylated with CuI, although no system for the selective O-arylation could be found. Coupling partners with diverse electronic properties and a variety of functional groups can be selectively transformed under these conditions. PMID:19899753

  15. Metabolites of 2-aminophenol from fruit bodies of Lepiota americana (Agaricales).

    PubMed

    Aulinger, K; Arnold, N; Steglich, W

    2000-01-01

    From the acetone extract of the North American toadstool Lepiota americana 2-aminophenoxazin-3-one (1) and a novel amino-1,4-benzoquinone derivative, lepiotaquinone (2), were isolated. The structure of 2 was confirmed by its preparation from 2-aminophenol and amino-1,4-benzoquinone.

  16. Synthetic, Spectroscopic and DFT Studies of Iron Complexes with Iminobenzo(semi)quinone Ligands: Implications for o-Aminophenol Dioxygenases

    PubMed Central

    Bittner, Michael M.; Kraus, David; Lindeman, Sergey V.; Popescu, Codrina V.; Fiedler, Adam T.

    2014-01-01

    The oxidative C-C bond cleavage of o-aminophenols by nonheme Fe dioxygenases is a critical step in both human metabolism (the kynurenine pathway) and the microbial degradation of nitroaromatic pollutants. The catalytic cycle of o-aminophenol dioxygenases (APDOs) has been proposed to involve formation of an Fe(II)/O2/iminobenzosemiquinone complex, although the presence of a substrate radical has been called into question by studies of related ring-cleaving dioxygenases. Recently, we reported the first synthesis of an iron(II) complex coordinated to an iminobenzosemiquinone (ISQ) ligand, namely, [Fe(Ph2Tp)(ISQtBu)] (2a; where Ph2Tp = hydrotris(3,5-diphenylpyrazol-1-yl)borate and ISQtBu is the radical anion derived from 2-amino-4,6-di-tert-butylphenol). In the current manuscript, density functional theory (DFT) calculations and a wide variety of spectroscopic methods (electronic absorption, Mössbauer, magnetic circular dichroism, and resonance Raman) were employed to obtain detailed electronic-structure descriptions of 2a and its one-electron oxidized derivative [3a]+. In addition, we describe the synthesis and characterization of a parallel series of complexes featuring the neutral supporting ligand tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (Ph2TIP). The isomer shifts of ~0.97 mm/s obtained via Mössbauer experiments confirm that 2a (and its Ph2TIP-based analogue [2b]+) contain Fe(II) centers, and the presence of an ISQ radical was verified by analysis of the absorption spectra in light of time-dependent DFT calculations. The collective spectroscopic data indicate that one-electron oxidation of the Fe2+–ISQ complexes yields complexes ([3a]+ and [3b]2+) with electronic configurations between the Fe3+–ISQ and Fe2+–IBQ limits (IBQ = iminobenzoquinone), highlighting the ability of o-amidophenolates to access multiple oxidation states. The implications of these results for the mechanism of APDOs and other ring-cleaving dioxygenases are discussed. PMID

  17. Reaction between lawsone and aminophenol derivatives: Synthesis, characterization, molecular structures and antiproliferative activity

    NASA Astrophysics Data System (ADS)

    Kathawate, Laxmi; Joshi, Pranya V.; Dash, Tapan Kumar; Pal, Sanjima; Nikalje, Milind; Weyhermüller, Thomas; Puranik, Vedavati G.; Konkimalla, V. Badireenath; Salunke-Gawali, Sunita

    2014-10-01

    Reaction between two bioreductive reactants lawsone (2-hydroxy-1,4-napthoquinone) and derivatives 2-aminophenol without catalyst is reported. The reaction between lawsone and 4-chloro-2-aminophenol leads to formation of red colored major product 1A:[2-[(5-chloro-hydroxyphenyl)amino]naphthalene-1,4-dione] and fluorescent orange colored minor compound 1B:[10-chloro-benzo[α]phenoxazine-5-one]. Molecular structure of 1A and 1B were determined by single crystal X-ray diffraction. Two mechanisms were proposed to the formation of red 1A and 1B. ‘Ortho-para’ tautomeric equilibrium was observed in DMSO-d6 solution in 1A, which was revealed by 1H, 13C NMR and LC-MS studies. Molecules of 1A formed dimers via Nsbnd H⋯O interaction and polymeric chain of dimers was formed by Osbnd H⋯O interactions. Cl⋯Cl interactions were observed between the polymeric chains of dimers in 1A. Molecules of 1B show Cl⋯N interaction. Antiproliferative properties is studied for 1A-5A compounds (obtained by the reaction of lawsone with 2-amino-4-methylphenol;2A, 2-aminophenol;3A, 3-aminophenol;4A and 4-aminophenol;5A) and evaluated against two cancer cell lines, THP1 (human monocytic leukemia cells) and COLO205 (colorectal adenocarcinoma) and one normal cell line, HEK293T (human embryonic kidney). The values of 50% inhibitory concentration (IC50) of compounds 1A-5A was determined using XTT assay. The cytotoxic effects of compounds 2A and 3A were observed against COLO205 and compounds 4A and 5A on THP1 were observed to be higher in comparison to their effect on HEK293T cell lines.

  18. Mass analyzed threshold ionization spectroscopy of p -aminophenol cation and the substitution effect

    NASA Astrophysics Data System (ADS)

    Xie, Yan; Lin, Jung Lee; Tzeng, Wen Bih

    2004-10-01

    The mass analyzed threshold ionization (MATI) spectra of p-aminophenol have been recorded by ionizing via the vibrationless 0 0 and vibrational 6a 1, 12 1, and 1 1 levels in the S 1 state. The adiabatic ionization energy (IE) of this molecule is determined to be 58,822 ± 5 cm -1. The frequencies of ring vibrational modes 6a, 12, 1, and 18b of the cation are measured to be 458, 768, 835, and 1181 cm -1, respectively. Comparing these new data of p-aminophenol with those of several p-substituted anilines and p-substituted phenols leads to a better understanding about the substitution effects on the IE as well as the cation vibration.

  19. Highly sensitive and simultaneous electrochemical determination of 2-aminophenol and 4-aminophenol based on poly(l-arginine)-β-cyclodextrin/carbon nanotubes@graphene nanoribbons modified electrode.

    PubMed

    Yi, Yinhui; Zhu, Gangbing; Wu, Xiangyang; Wang, Kun

    2016-03-15

    Owing to the similar characteristics and physiochemical property of 2-aminophenol (2-AP) and 4-aminophenol (4-AP), the highly sensitive simultaneous electrochemical determination of 2- and 4-AP is a great challenge. In this paper, by electropolymerizing β-cyclodextrin (β-CD) and l-arginine (l-Arg) on the surface of carbon nanotubes@graphene nanoribbons (CNTs@GNRs) core-shell heterostructure, a P-β-CD-l-Arg/CNTs@GNRs nanohybrid modified electrode was prepared successfully, and it could exhibit the synergetic effects of β-CD (high host-guest recognition and enrichment ability), l-Arg (excellent electrocatalytic activity) and CNTs@GNRs (prominent electrochemical properties and large surface area), the P-β-CD-l-Arg/CNTs@GNRs modified electrode was used in the electrochemical determination of 2- and 4-AP, the results demonstrated that the highly sensitive and simultaneous determination of 2- and 4-AP is successfully achieved and the modified electrode has a linear response range of 25.0-1300.0 nM for both 2- and 4-AP, and the detection limits of 2- and 4-AP obtained in this work are 6.2 and 3.5 nM, respectively.

  20. Simultaneous determination of N-acetyl-p-aminophenol and p-aminophenol with poly(3,4-ethylenedioxythiophene) modified glassy carbon electrode.

    PubMed

    Mehretie, Solomon; Admassie, Shimelis; Hunde, Tadele; Tessema, Merid; Solomon, Theodros

    2011-09-15

    A sensitive and selective method was developed for the determination of N-acetyl-p-aminophenol (APAP) and p-aminophenol (PAP) using poly(3,4-ethylenedioxythiophene) (PEDOT)-modified glassy carbon electrode (GCE). Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical reaction of APAP and PAP at the modified electrode. Both APAP and PAP showed quasireversible redox reactions with formal potentials of 367 mV and 101 mV (vs. Ag/AgCl), respectively, in phosphate buffer solution of pH 7.0. The significant peak potential difference (266 mV) between APAP and PAP enabled the simultaneous determination both species based on differential pulse voltammetry. The voltammetric responses gave linear ranges of 1.0×10(-6)-1.0×10(-4) mol L(-1) and 4.0×10(-6)-3.2×10(-4) mol L(-1), with detection limits of 4.0×10(-7) mol L(-1) and 1.2×10(-6) mol L(-1) for APAP and PAP, respectively. The method was successfully applied for the determination of APAP and PAP in pharmaceutical formulations and biological samples.

  1. Biomimetic metal-radical reactivity: aerial oxidation of alcohols, amines, aminophenols and catechols catalyzed by transition metal complexes.

    PubMed

    Chaudhuri, Phalguni; Wieghardt, Karl; Weyhermüller, Thomas; Paine, Tapan K; Mukherjee, Soumen; Mukherjee, Chandan

    2005-10-01

    The contributions of the authors to the research program 'Radicals in Enzymatic Catalysis' over the last ca. 5 years are summarized. Significant efforts were directed towards the design and testing of phenol-containing ligands for synthesizing radical-containing transition metal complexes as potential candidates for catalysis of organic substrates like alcohols, amines, aminophenols and catechols. Functional models for different copper oxidases, such as galactose oxidase, amine oxidases, phenoxazinone synthase and catechol oxidase, are reported. The copper complexes synthesized can mimic the function of the metalloenzymes galactose oxidase and amine oxidases by catalyzing the aerial oxidation of alcohols and amines. Even methanol could be oxidized, albeit with a low conversion, by a biradical-copper(II) compound. The presence of a primary kinetic isotope effect, similar to that for galactose oxidase, provides compelling evidence that H-atom abstraction from the alpha-C-atom of the substrates is the rate-limiting step. Although catechol oxidase and phenoxazinone synthase contain copper, manganese(IV) complexes containing radicals have been found to be useful to study synthetic systems and to understand the naturally occurring processes. An 'on-off' mechanism of the radicals without redox participation from the metal centers seems to be operative in the catalysis involving such metal-radical complexes.

  2. Mixed mode and sequential oscillations in the cerium-bromate-4-aminophenol photoreaction

    SciTech Connect

    Bell, Jeffrey G.; Wang Jichang

    2013-09-15

    Cerium was introduced to the bromate-aminophenol photochemical oscillator to implement coupled autocatalytic feedbacks. Mixed mode and sequential oscillations emerged in the studied system, making it one of the few chemical oscillators known to support consecutive bifurcations in a batch system. The complex reaction behavior showed a strong dependence on the intensity of illumination supplied to the system. Removal of illumination during an oscillatory window affected both the frequency and amplitude of the oscillation but did not fully extinguish them, indicating that the cerium-bromate-4-aminophenol oscillator was photosensitive rather than photo-controlled. A moderate light intensity allowed for a slow evolution of the system, which proved to be critical for the emergence of transient complex oscillations. Variation of individual reaction parameters was carried out, which indicated that the development of complex oscillations occur in a narrow region and a phase diagram in the 4-aminophenol and sulfuric acid plane demonstrated this. Simulations provide strong support that transient complex oscillations observed experimentally arise from the coupling of two autocatalytic cycles.

  3. Effects of the analgesic acetaminophen (Paracetamol) and its para-aminophenol metabolite on viability of mouse-cultured cortical neurons.

    PubMed

    Schultz, Stephen; DeSilva, Mauris; Gu, Ting Ting; Qiang, Mei; Whang, Kyumin

    2012-02-01

    Acetaminophen has been used as an analgesic for more than a hundred years, but its mechanism of action has remained elusive. Recently, it has been shown that acetaminophen produces analgesia by the activation of the brain endocannabinoid receptor CB1 through its para-aminophenol (p-aminophenol) metabolite. The objective of this study was to determine whether p-aminophenol could be toxic for in vitro developing mouse cortical neurons as a first step in establishing a link between acetaminophen use and neuronal apoptosis. We exposed developing mouse cortical neurons to various concentrations of drugs for 24 hr in vitro. Acetaminophen itself was not toxic to developing mouse cortical neurons at therapeutic concentrations of 10-250 μg/ml. However, concentrations of p-aminophenol from 1 to 100 μg/ml produced significant (p < 0.05) loss of mouse cortical neuron viability at 24 hr compared to the controls. The naturally occurring endocannabinoid anandamide also caused similar 24-hr loss of cell viability in developing mouse cortical neurons at concentrations from 1 to 100 μg/ml, which indicates the mechanism of cell death could be through the cannabinoid receptors. The results of our experiments have shown a detrimental effect of the acetaminophen metabolite p-aminophenol on in vitro developing cortical neuron viability which could act through CB1 receptors of the endocannabinoid system. These results could be especially important in recommending an analgesic for children or individuals with traumatic brain injury who have developing cortical neurons.

  4. Synthesis and Characterization with Antineoplastic, Biochemical, Cytotoxic, and Antimicrobial Studies of Schiff Base Cu(II) Ion Complexes

    PubMed Central

    Haque, M. M.; Kudrat-E-Zahan, Md.; Banu, Laila Arjuman; Islam, Md. Shariful; Islam, M. S.

    2015-01-01

    Copper(II) complexes containing two Schiff base ligands derived from 2-hydroxybenzaldehyde with 2-aminophenol and 3-aminophenol have been synthesized and characterized by means of analytical, magnetic, and spectroscopic methods. Bacteria, fungus, Entamoeba histolytica, and antineoplastic activities of the synthesized complexes have been determined by monitoring the parameters cell growth inhibition, survival time of tumour mice, time-body relation, causing of intraperitoneal cells and macrophages, alkaline phosphatase activity, hematological effect, and biopsy of tumour. PMID:26294901

  5. 40 CFR Table 2 to Subpart Ooo of... - Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (HAP) From the Manufacture of Amino/Phenolic Resins 2 Table 2 to Subpart OOO of Part 63 Protection of... Hazardous Air Pollutant Emissions: Manufacture of Amino/Phenolic Resins Pt. 63, Subpt. OOO, Table 2 Table 2 to Subpart OOO of Part 63—Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of...

  6. 40 CFR Table 2 to Subpart Ooo of... - Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of Amino/Phenolic Resins

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (HAP) From the Manufacture of Amino/Phenolic Resins 2 Table 2 to Subpart OOO of Part 63 Protection of... Hazardous Air Pollutant Emissions: Manufacture of Amino/Phenolic Resins Pt. 63, Subpt. OOO, Table 2 Table 2 to Subpart OOO of Part 63—Known Organic Hazardous Air Pollutants (HAP) From the Manufacture of...

  7. Permeation of hair dye ingredients, p-phenylenediamine and aminophenol isomers, through protective gloves.

    PubMed

    Lee, Hsiao-Shu; Lin, Yu-Wen

    2009-04-01

    Skin irritation and contact allergies are skin disorders common to hairdressers. The predominant oxidative hair dye components, such as p-phenylenediamine (PPD) and aminophenol isomers, can cause contact dermatitis. Use of protective gloves can prevent dermal contact with skin irritants. This study investigates the permeation behaviors of p-aminophenol (PAP), m-aminophenol (MAP), o-aminophenol (OAP) and PPD in single and mixed challenge solutions with disposable natural rubber latex (NRL) gloves, disposable polyvinylchloride (PVC) gloves and neoprene (NP) gloves. The challenge solutions were 4% PPD (w/v), 3% OAP (w/v), 2% PAP (w/v) and 2% MAP (w/v) in ethanol or 12% hydrogen peroxide solutions. The cocktail solutions of the four chemicals were also tested. An American Society for Testing and Materials type permeation cell, ethanol liquid collection and gas chromatography-flame ionization detection of samples taken from the collection medium every 10 min facilitated determination of breakthrough times (BTs), cumulative permeated masses and steady-state permeation rates (SSPRs). Experiments were 4 h long for the NRL and PVC gloves and 8 h for NP gloves. No chemicals tested broke through the NP gloves when exposed for 8 h. In the ethanol solution, PPD and OAP started breaking through the PVC gloves at 40 min. The SSPRs of PVC gloves were higher than those for NRL gloves in all challenge conditions for both single chemicals and mixtures. No tested chemicals in hydrogen peroxide solutions permeated the gloves during the 4-h tests. The chemical composition of the challenge solution was a main effecter of BTs and SSPRs for the NRL glove. For disposable PVC gloves, the main factors of BTs were molecular size [molar volume (MV)] and polarity (logK(ow)), and the primary factors of SSPRs were concentration, MV and logK(ow). In conclusion, disposable NRL gloves and disposable PVC gloves should not be used repeatedly for handling the hair dye products. Hydrogen peroxide did not

  8. Disentangling formation of multiple-core holes in aminophenol molecules exposed to bright X-FEL radiation

    DOE PAGES

    Zhaunerchyk, V.; Kaminska, M.; Mucke, M.; ...

    2015-10-28

    Competing multi-photon ionization processes, some leading to the formation of double core hole states, have been examined in 4-aminophenol. The experiments used the linac coherent light source (LCLS) x-ray free electron laser, in combination with a time-of-flight magnetic bottle electron spectrometer and the correlation analysis method of covariance mapping. Furthermore, the results imply that 4-aminophenol molecules exposed to the focused x-ray pulses of the LCLS sequentially absorb more than two x-ray photons, resulting in the formation of multiple core holes as well as in the sequential removal of photoelectrons and Auger electrons (so-called PAPA sequences).

  9. A computational study on the enhanced stabilization of aminophenol derivatives by internal hydrogen bonding

    NASA Astrophysics Data System (ADS)

    Gomes, José R. B.; Ribeiro da Silva, Manuel A. V.

    2006-05-01

    The stabilization of aminophenol derivatives and their radicals due to internal hydrogen bonding has been analyzed by means of density functional theory and by topological electron density analysis. The calculations have been carried out at the B3LYP level of theory, using several basis sets, and by means of the CBS-4M composite approach. A strong O-H⋯NH 2 hydrogen bond is found to stabilize the aminophenol with the lone-pair of the nitrogen atom co-planar with the aromatic ring, contrasting with the optimized structure found for aniline. The effect of electron donors and electron acceptors on the strength of the internal hydrogen bond is also analyzed. For one of the species studied, 2,6-diaminophenol, the computed O-H bond dissociation enthalpy is only 300 kJ/mol, the lowest value found so far for phenol and other compounds containing the O-H bond, almost 25 kJ/mol lower than those found experimentally for pyrogallol and for vitamin E. The explanation for such a small value comes from the enhanced stabilization of the corresponding radical species by internal hydrogen bonding, combined with a decrease of the steric effects caused by rotation of the amino groups.

  10. Chlorination and monochloramination of 3-aminophenol: kinetics and formation of first by-products.

    PubMed

    Abou Mehrez, O; Dossier-Berne, F; Legube, B

    2015-01-01

    Aminophenols (AP) are synthetic intermediates in pharmaceutical, photographic and chemical dye industry. They can be released into the environment from wastewater and can react during water treatment processes. Therefore, it was interesting to study the oxidation of AP with chlorine and monochloramine in aqueous solution. In particular, the chlorination and monochloramination of 3-aminophenol (3AP) were investigated, and the formation of first by-products and kinetic rates were determined. The chlorination rate was 3.6 × 10(5) times greater than the monochloramination rate at pH 8.6. Two reaction pathways can explain the variation of the monochloramination apparent rate constant with pH. The first one was an electrophilic substitution of Cl(+) on the aromatic ring of the non-ionized 3AP, leading to the formation of chloroaminophenol, with an individual rate constant of 6.7 × 10(2) M(-1) h(-1). The second reaction pathway was a monochloramine attack on the amino group of 3AP catalyzed at acidic pH with an individual rate constant of 9.2 × 10(9) × M(-2) × h(-1).

  11. Simultaneous determination of p-phenylenediamines and aminophenols in hair dye products: interlaboratory study.

    PubMed

    Yeh, Yu-Chun; Wu, Hui-Jung; Huang, Wei-Sheng; Lin, Cheng-Chin; Chen, Yu-Pen; Tzou, Mei-Chyun; Tsai, Jui-Chen

    2011-01-01

    An isocratic HPLC method routinely used in the National Laboratory for Food and Drug Analysis of Taiwan was validated for the simultaneous determination of six aminophenols and phenylenediamines in commercial hair dyes. After extraction of the commercial hair dye product, the dye intermediates were determined by HPLC. Recoveries from the extraction were between 91.6 and 96.5%. The method was then evaluated in an interlaboratory collaborative study according to AOAC guidelines. Five laboratories in Taiwan participated in the study that analyzed the test product, which was preanalyzed by two laboratories to ensure acceptable homogeneity. The RSD(r) and RSD(R) values of the measurements obtained for the dye intermediates in the product were < or = 3.75 and < or = 5.95%, respectively. The method demonstrated acceptable reproducibility, as evidenced by HorRat values of 0.82- 0.97. The applicability of the method to the determination of oxidative hair dye components was further demonstrated in analyses of two different products. The method is thus proposed to be used by manufacturers and laboratories to evaluate the quality of commercial hair dyes containing the six aminophenols and phenylenediamines.

  12. Nickel embedded in N-doped porous carbon for the hydrogenation of nitrobenzene to p-aminophenol in sulphuric acid.

    PubMed

    Wang, Tao; Dong, Zhen; Fu, Teng; Zhao, Yanchao; Wang, Tian; Wang, Yongzheng; Chen, Yi; Han, Baohang; Ding, Weiping

    2015-12-28

    An acid-resistant catalyst composed of nickel embedded in N-doped porous carbon is developed for the catalytic hydrogenation of nitrobenzene (NB) to p-aminophenol (PAP). The catalyst, due to a special electron donation from nickel to the N-doped porous carbon, shows an excellent catalytic performance and stability in sulphuric acid solution.

  13. Far-Ir Action Spectroscopy of Aminophenol and Ethylvanillin: Experiment and Theory

    NASA Astrophysics Data System (ADS)

    Yatsyna, Vasyl; Feifel, Raimund; Zhaunerchyk, Vitali; Bakker, Daniël; Rijs, Anouk

    2015-06-01

    Investigations of molecular structure and conformational isomerism are at the forefront of today's biophysics and biochemistry. In particular, vibrations excited by far-IR radiation can be highly sensitive to the molecular 3D structure as they are delocalized over large parts of the molecule. Current theoretical predictions of vibrational frequencies in the far-IR range are not accurate enough because of the non-local character and anharmonicity of these vibrations. Therefore experimental studies in the far-IR are vital to guide theory towards improved methodology. In this work we present the conformer-specific far-IR spectra of aminophenol and ethylvanillin molecules in the range of 220-800 wn utilizing ion-dip action spectroscopy carried out at the free electron laser FELIX in Nijmegen, Netherlands. The systems studied are aromatic molecules with important functional groups such as the hydroxyl (OH) and amino (NH_2) groups in aminophenol, and the hydroxyl, ethoxy (OCH_2CH_3) and formyl (CHO) groups in ethylvanillin. The experimental spectra show well resolved conformer-specific vibrational bands. In the case of ethylvanillin only two planar conformers have been observed under supersonic jet expansion conditions. Despite the fact that these conformers differ only in the position of oxygen of the formyl group with respect to ethoxy group, they are well distinguishable in far-IR spectra. The capability of numerical methods based on density functional theory (DFT) for predicting vibrational frequencies in this spectral region within the harmonic approximation has been investigated by using several hybrid-functionals such as B3LYP, PBE0, B2PLYP and CAM-B3LYP. An anharmonic correction based on vibrational second order perturbation theory approach was also applied. We have found that the methods we considered are well suited for the assignment of far-IR vibrational features except the modes which are strongly anharmonic, like the NH_2 wagging mode in aminophenol which

  14. Synthesis, antibacterial screening and DFT studies of series of α-amino-phosphonates derivatives from aminophenols

    NASA Astrophysics Data System (ADS)

    Hellal, Abdelkader; Chafaa, Salah; Chafai, Nadjib; Touafri, Lasnouni

    2017-04-01

    A series of α-aminophosphonate derivatives containing aminophenol moiety have been synthesized and evaluated for their antibacterial activities against two clinical strains Gram-positive and two Gram-negative applying Agar disc diffusion method, Minimal Inhibition Concentration (MIC) and Minimal Bactericidal Concentration (MBC) methods. The chemical structures of the synthesized compounds were verified on the basis of spectral data and elemental analyses. These compounds have significant bactericide activity with totalities of bacterial strains used. DFT calculations with B3LYP/6-31G (d,p) level have been used to analyze the electronic and geometric characteristics deduced for the stable structure of the compounds. The principal quantum chemical descriptors (HOMO, LUMO, MESP) have been correlated with the antibacterial activity.

  15. Design and evaluation of 4-aminophenol and salicylate derivatives as free-radical scavenger.

    PubMed

    Borges, Rosivaldo S; Pereira, Glaécia A N; Vale, Joyce K L; França, Luiz C S; Monteiro, Marta C; Alves, Cláudio N; da Silva, Albérico B F

    2013-03-01

    This theoretical and experimental study describes the design and evaluation of the free-radical scavenging effect for the molecular association of 4-aminophenol and salicylate derivatives. For this purpose, we employed theoretical methods for the selection of antioxidant drugs and the rapid methods of evaluation: the 1,1-diphenyl-2-picrylhydrazyl radical and the thiobarbituric acid reactive substances in the lipid peroxidation initiated by Fe(2+) and ascorbic acid in human erythrocytes. The associate derivatives exhibited a more potent inhibition than the salicylic acid, while the benzoyl compound exhibited a more potent inhibition than paracetamol. The molecular parameters related to the electron distribution and structure (ionization potential and energy of the highest occupied molecular orbital) correlated very well with the antioxidant action of the compounds studied here in different tests.

  16. Substrate-dependent aromatic ring fission of catechol and 2-aminophenol with O2 catalyzed by a nonheme iron complex of a tripodal N4 ligand.

    PubMed

    Lakshman, Triloke Ranjan; Chatterjee, Sayanti; Chakraborty, Biswarup; Paine, Tapan Kanti

    2016-06-07

    The catalytic reactivity of an iron(ii) complex [(TPA)Fe(II)(CH3CN)2](2+) (1) (TPA = tris(2-pyridylmethyl)amine) towards oxygenative aromatic C-C bond cleavage of catechol and 2-aminophenol is presented. Complex 1 exhibits catalytic and regioselective C-C bond cleavage of 3,5-di-tert-butylcatechol (H2DBC) to form intradiol products, whereas it catalyzes extradiol-type C-C bond cleavage of 2-amino-4,6-di-tert-butylphenol (H2AP). The catalytic reactions are found to be pH-dependent and the complex exhibits maximum turnovers at pH 5 in acetonitrile-phthalate buffer. An iron(iii)-catecholate complex [(TPA)Fe(III)(DBC)](+) (2) is formed in the ring cleavage of catechol. In the extradiol-type cleavage of H2AP, an iron(iii)-2-iminobenzosemiquinonate complex [(TPA)Fe(III)(ISQ)](2+) (3) (ISQ = 4,6-di-tert-butyl-2-iminobenzosemiquinonate radical anion) is observed in the reaction pathway. This work shows the importance of the nature of 'redox non-innocent' substrates in governing the mode of ring fission reactivity.

  17. Synthesis of nitrogen-doped activated graphene aerogel/gold nanoparticles and its application for electrochemical detection of hydroquinone and o-dihydroxybenzene.

    PubMed

    Juanjuan, Zhang; Ruiyi, Li; Zaijun, Li; Junkang, Liu; Zhiguo, Gu; Guangli, Wang

    2014-05-21

    Graphene aerogel materials have attracted increasing attention owing to their large specific surface area, high conductivity and electronic interactions. Here, we report for the first time a novel strategy for the synthesis of nitrogen-doped activated graphene aerogel/gold nanoparticles (N-doped AGA/GNs). First, the mixture of graphite oxide, 2,4,6-trihydroxybenzaldehyde, urea and potassium hydroxide was dispersed in water and subsequently heated to form a graphene oxide hydrogel. Then, the hydrogel was dried by freeze-drying and reduced by thermal annealing in an Ar/H2 environment in sequence. Finally, GNs were adsorbed on the surface of the N-doped AGA. The resulting N-doped AGA/GNs offers excellent electronic conductivity (2.8 × 10(3) S m(-1)), specific surface area (1258 m(2) g(-1)), well-defined 3D hierarchical porous structure and apparent heterogeneous electron transfer rate constant (40.78 ± 0.15 cm s(-1)), which are notably better than that of previous graphene aerogel materials. Moreover, the N-doped AGA/GNs was used as a new sensing material for the electrochemical detection of hydroquinone (HQ) and o-dihydroxybenzene (DHB). Owing to the greatly enhanced electron transfer and mass transport, the sensor displays ultrasensitive electrochemical response to HQ and DHB. Its differential pulse voltammetric peak current linearly increases with the increase of HQ and DHB in the range of 5.0 × 10(-8) to 1.8 × 10(-4) M for HQ and 1 × 10(-8) to 2.0 × 10(-4) M for DHB. The detection limit is 1.5 × 10(-8) M for HQ and 3.3 × 10(-9) M for DHB (S/N = 3). This method provides the advantage of sensitivity, repeatability and stability compared with other HQ and DHB sensors. The sensor has been successfully applied to detection of HQ and DHB in real water samples with the spiked recovery in the range of 96.8-103.2%. The study also provides a promising approach for the fabrication of various graphene aerogel materials with improved electrochemical performances, which

  18. Visual and colorimetric detection of p-aminophenol in environmental water and human urine samples based on anisotropic growth of Ag nanoshells on Au nanorods.

    PubMed

    Lin, Tianran; Li, Zhihong; Song, Zhiping; Chen, Huan; Guo, Liangqia; Fu, Fengfu; Wu, Zujian

    2016-01-01

    A simple, sensitive, selective and high-resolution colorimetric method has been developed for the detection of p-aminophenol in environmental water and human urine samples. In the presence of p-aminophenol, silver ions are reduced to silver atoms and subsequently Ag nanoshells anisotropically grow on the surface of Au nanorods to generate orange slice-like Au@Ag core-shell nanocrystals, thereby resulting in the blue-shift of longitudinal surface plasmon resonance band of Au nanorods accompanying a sharp-contrast multicolor change. Using Au@Ag core-shell nanocrystals as the transducer, sub-micromolar p-aminophenol can be detected by the colorimetric method and 10 μmol L(-1) p-aminophenol can be visual readout by the naked eyes. Furthermore, a simple, cheap, portable test kit is constructed for the visual assay of urinary p-aminophenol without complicated sample pretreatment and sophisticated instruments. The proposed colorimetric method has the potential for the rapid and on-site analyses of p-aminophenol in environmental water and human urine samples.

  19. Horseradish Peroxidase (HRP) Immobilized Poly(aniline-co-m-aminophenol) Film Electrodes–fabrication and Evaluation as Hydrogen Peroxide Sensor

    PubMed Central

    Seo, Kang-Deuk; Lee, Kwang-Pill; Gopalan, Anantha Iyengar; Chung, Sang J.; Lim, Yong Taik; Choi, Seong-Ho

    2007-01-01

    Enzyme modified electrodes were fabricated with poly (aniline-co-m-aminophenol). Electrochemical polymerization of aniline and m-aminophenol was performed to get the film of copolymer on the surface of gold electrode. Modified electrodes were fabricated by two methods, physical entrapment and covalent cross-linking. In one of the method, gold nanoparticles were loaded into the copolymer film and horseradish peroxidase (HRP) was immobilized into the Au nanoparticle loaded copolymer film through physical entrapment. In the other method, the amino and -OH groups in the copolymer are utilized to form covalent functionalization with HRP via glutaric dialdehyde as cross-linker/mediator. The conducting copolymer/enzyme modified electrodes prepared by physical entrapment/covalent functionalization of enzyme were tested for electrocatalytic activities towards sensing of H2O2. Amperometric results indicate that enzyme modified electrode via physical entrapment possesses better electrocatalytic performance over covalent functionalized enzyme electrode.

  20. High content analysis of an in vitro model for metabolic toxicity: results with the model toxicants 4-aminophenol and cyclophosphamide.

    PubMed

    Cole, Stephanie D; Madren-Whalley, Janna S; Li, Albert P; Dorsey, Russell; Salem, Harry

    2014-12-01

    In vitro models that accurately and rapidly assess hepatotoxicity and the effects of hepatic metabolism on nonliver cell types are needed by the U.S. Department of Defense and the pharmaceutical industry to screen compound libraries. Here, we report the first use of high content analysis on the Integrated Discrete Multiple Organ Co-Culture (IdMOC) system, a high-throughput method for such studies. We cultured 3T3-L1 cells in the presence and absence of primary human hepatocytes, and exposed the cultures to 4-aminophenol and cyclophosphamide, model toxicants that are respectively detoxified and activated by the liver. Following staining with calcein-AM, ethidium homodimer-1, and Hoechst 33342, high content analysis of the cultures revealed four cytotoxic endpoints: fluorescence intensities of calcein-AM and ethidium homodimer-1, nuclear area, and cell density. Using these endpoints, we observed that the cytotoxicity of 4-aminophenol in 3T3-L1 cells in co-culture was less than that observed for 3T3-L1 monocultures, consistent with the known detoxification of 4-aminophenol by hepatocytes. Conversely, cyclophosphamide cytotoxicity for 3T3-L1 cells was enhanced by co-culturing with hepatocytes, consistent with the known metabolic activation of this toxicant. The use of IdMOC plates combined with high content analysis is therefore a multi-endpoint, high-throughput capability for measuring the effects of metabolism on toxicity.

  1. Degradation of 4-chloro 2-aminophenol using combined strategies based on ultrasound, photolysis and ozone.

    PubMed

    Barik, Arati J; Gogate, Parag R

    2016-01-01

    The present work investigates the degradation of 4-chloro 2-aminophenol (4C2AP), a highly toxic organic compound, using ultrasonic reactors and combination of ultrasound with photolysis and ozonation for the first time. Two types of ultrasonic reactors viz. ultrasonic horn and ultrasonic bath operating at frequency of 20 kHz and 36 kHz respectively have been used in the work. The effect of initial pH, temperature and power dissipation of the ultrasonic horn on the degradation rate has been investigated. The established optimum parameters of initial pH as 6 (natural pH of the aqueous solution) and temperature as 30 ± 2°C were then used in the degradation studies using the combined approaches. Kinetic study revealed that degradation of 4C2AP followed first order kinetics for all the treatment approaches investigated in the present work. It has been established that US+UV+O3 combined process was the most promising method giving maximum degradation of 4C2AP in both ultrasonic horn (complete removal) and bath (89.9%) with synergistic index as 1.98 and 1.29 respectively. The cavitational yield of ultrasonic bath was found to be eighteen times higher as compared to ultrasonic horn implying that configurations with higher overall areas of transducers would be better selection for large scale treatment. Overall, the work has clearly demonstrated that combined approaches could synergistically remove the toxic pollutant (4C2AP).

  2. Poly(o-aminophenol)-modified bienzyme carbon paste electrode for the detection of uric acid.

    PubMed

    Miland, E; Miranda Ordieres, A J; Tuñón Blanco, P; Smyth, M R; Fágáin, C O

    1996-05-01

    A reagentless uric acid selective biosensor constructed by immobilising uricase and horseradish peroxidase (HRP) in carbon paste without the addition of an electron transfer mediator is described. The response of the electrode is based on the enzymatic reduction of hydrogen peroxide in the presence of uric acid. Uricase and HRP were dispersed in the carbon paste and the optimum paste mixture was determined. Poly(o-aminophenol) was electropolymerised at the working surface area of the electrode acting as a conducting polymer layer. Cyclic voltammetry was used to characterise the permselective characteristics of the polymer layer. At an applied potential of 50 mV vs. Ag/AgCl, a linear response was obtained up to 1 x 10(-4) M, with a limit of detection of 3 x 10(-6) M. The sensor had a response time of 37 s. a calibration precision of 2.2% (n = 4) and an estimated sample frequency of 20 h(-1). Responses to the analyte of interest were pH dependent. The sensor was incorporated into a flow injection system for the qualification of uric acid in human serum. Results compared favourably with a standard spectrophotometric method.

  3. Vibrational predissociation and vibrationally induced isomerization of 3-aminophenol-ammonia

    SciTech Connect

    Heid, Cornelia G.; Merrill, Wyatt G.; Case, Amanda S. Crim, F. Fleming

    2015-01-07

    We investigate the vibrational predissociation dynamics of the hydrogen-bonded 3-aminophenol-ammonia cluster (3-AP-NH{sub 3}) in the OH and NH stretching regions. Vibrational excitation provides enough energy to dissociate the cluster into its constituent 3-AP and NH{sub 3} monomers, and we detect the 3-AP fragments via (1 + 1) resonance-enhanced multiphoton ionization (REMPI). The distribution of vibrational states of the 3-AP fragment suggests the presence of two distinct dissociation pathways. The first dissociation channel produces a broad, unstructured feature in the REMPI-action spectrum after excitation of any of the OH or NH stretching vibrations, pointing to a nearly statistical dissociation pathway with extensive coupling among the vibrations in the cluster during the vibrational predissociation. The second dissociation channel produces distinct, resolved features on top of the broad feature but only following excitation of the OH or symmetric NH{sub 3} stretch in the cluster. This striking mode-specificity is consistent with strong coupling of these two modes to the dissociation coordinate (the O–H⋯N bond). The presence of clearly resolved transitions to the electronic origin and to the 10a{sup 2} + 10b{sup 2} state of the cis-3-AP isomer shows that vibrational excitation is driving the isomerization of the trans-3-AP-NH{sub 3} isomer to the cis-3-AP-NH{sub 3} isomer in the course of the dissociation.

  4. Development of an optical fibre reflectance sensor for p-aminophenol detection based on immobilised bis-8-hydroxyquinoline.

    PubMed

    Filik, Hayati; Hayvali, Mustafa; Kiliç, Emine; Apak, Reşat; Aksu, Duygu; Yanaz, Zeynep; Cengel, Tayfun

    2008-10-19

    2,2'-(1,4-Phenylenedivinylene)bis-8-hydroxyquinoline (PBHQ), a highly sensitive reagent used for the colorimetric determination of p-aminophenol (PAP), was successfully immobilised on XAD-7 and coupled with optical fibres to investigate a sensor-based approach for determining p-aminophenol. The solid-state sensor is based on the reaction of PAP with PBHQ in presence of an oxidant to produce an indophenol dye. The reflectance measurements were carried out at a wavelength of 647 nm since it yielded the largest divergence different in reflectance spectra before and after reaction with the analyte. The linear dynamic range of PAP was found within the concentration range of 0.1-2.18 mg l(-1) with its LOD of 0.02 mg l(-1). The sensor response from different probes (n=7) gave a R.S.D. of 4.4% at 1.09 mg l(-1) PAP concentration. The response time of the optical one-shot sensor was 5 min for a stable solution. As this PAP sensor is irreversible, a fresh sensor has to be used for each measurement. All the experimental parameters were optimized for the determination of PAP. Using the optical sensing probe, PAP in pharmaceutical wastewater and paracetamol was determined. The effect of potential interferences such as inorganic and organic compounds was also evaluated. Potential on-site determination of PAP with such sensors can indirectly aid detection of organo-phosphorus nerve agents and pesticides in the field by inhibition of acetylcholine esterase-catalyzed hydrolysis of p-aminophenyl acetate to p-aminophenol.

  5. Characterization, molecular modeling and antimicrobial activity of metal complexes of tridentate Schiff base derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and 2-aminophenol

    NASA Astrophysics Data System (ADS)

    Adly, Omima M. I.

    Metal complexes of Ni(II), Co(II), Cd(II), VO(IV) and UO2(VI) as well as several Cu(II) salts, including Cl,NO3-,AcO,ClO4- and SO4-2 with a tridentate O2N donor Schiff base ligand (H2L), synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 2-aminophenol, were prepared and characterized on the basis of elemental analyses, spectral, magnetic, molar conductance and thermal gravimetric analysis. Square planar, tetrahedral and octahedral geometries have been assigned to the prepared complexes. Molecular parameters of the ligand and its metal complexes have been calculated and correlated with the experimental data, and the changes of bond lengths are linearly correlated with IR data. The antimicrobial activities of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus as Gram positive bacteria, Proteus vulgaris as Gram negative bacteria and Candida albicans as fungus strain, and the results are discussed.

  6. X-ray diffraction and absorption spectroscopic studies of copper mixed ligand complexes with aminophenol as one of the ligands

    NASA Astrophysics Data System (ADS)

    Mishra, A.; Jain, Garima; Patil, H.

    2012-05-01

    X-ray diffraction (XRD) and X-ray absorption spectroscopic (XAS) studies have been conducted on two copper complexes, i.e., copper macrocyclic complex of succinic acid and ortho aminophenol (complex-1) and copper macrocyclic complex of pthalic acid and ortho aminophenol (complex-2). The diffraction pattern of the complexes have been recorded using Rigaku RINT-2000 X-ray diffractometer equipped with rotating anode X-ray tube operated at 40 kV and 100 mA. The X-ray absorption spectra of the complexes have been recorded at the K-edge of copper on Cauchois type bent crystal spectrograph having radius 0.4 m employing a mica crystal, oriented to reflect from (100) planes, for dispersion. The X-ray absorption near edge structure (XANES) parameters, viz., chemical shift, energy position of the principal absorption maximum and edge-width have been determined and discussed. From the extended X-ray absorption fine structure (EXAFS) data, the bond lengths have been calculated using three methods, namely, Levy's method, Lytle, Sayers and Stern's (LSS) method and Fourier transformation method. The results obtained have been compared with each other and discussed.

  7. Chemical reactions of conformationally selected 3-aminophenol molecules in a beam with Coulomb-crystallized Ca+ ions

    NASA Astrophysics Data System (ADS)

    Rösch, Daniel; Willitsch, Stefan; Chang, Yuan-Pin; Küpper, Jochen

    2014-03-01

    Many molecules exhibit multiple conformers that often easily interconvert under thermal conditions. Therefore, single conformations are difficult to isolate which renders the study of their distinct chemical reactivities challenging. We have recently reported a new experimental method for the characterization of conformer-specific effects in chemical reactions [Y.-P. Chang, K. Długołęcki, J. Küpper, D. Rösch, D. Wild, and S. Willitsch, "Specific chemical reactivities of spatially separated 3-aminophenol conformers with cold Ca+ ions," Science 342, 98-101 (2013)]. Different conformers are spatially separated using inhomogeneous electric fields and reacted with a Coulomb crystal of cold, spatially localized ions in a trap. As a first application, we studied reactions between the two conformers of 3-aminophenol and Ca+. We observed a twofold larger rate constant for the cis compared to the trans conformer which was rationalized in terms of the differences in the long-range ion-molecule interactions. The present article provides a detailed description of the new method and a full account of the experimental results as well as the accompanying theoretical calculations.

  8. Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes.

    PubMed

    Dömötör, Orsolya; de Almeida, Rodrigo F M; Côrte-Real, Leonor; Matos, Cristina P; Marques, Fernanda; Matos, António; Real, Carla; Kiss, Tamás; Enyedy, Éva Anna; Helena Garcia, M; Tomaz, Ana Isabel

    2017-03-01

    Two recently published Ru(III) complexes bearing (N2O2) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh3)Cl] (salan is the tetradentate ligand 6,6'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(3-methoxyphenol) in complex 1, or 2,2'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(4-methoxyphenol) in complex 2; PPh3 is triphenylphosphane) and found very active against ovarian and breast adenocarcinoma human cells were studied to outline their antitumor mode of action. The human cisplatin-sensitive ovarian adenocarcinoma line A2780 was used herein as the cell model. At a 24h challenge (similarly as found before for 72h) both complexes are active, their cytotoxicity being comparable to that of cisplatin in the same conditions. As a possible target in the cell for their action, the interaction of 1 and 2 with DNA was assessed through displacement of well-established DNA fluorescent probes (ethidium bromide, EB, and 4',6-diamidino-2-phenylindole, DAPI) through steady-state and time-resolved fluorescence spectroscopy. The whole emission spectra were analyzed globally for the binary DNA-probe and ternary DNA-probe-Ru(III) complex systems. Both Ru(III) complexes can displace EB and bind to DNA with similar and moderate strong affinity with conditional stability constants of logK'=(5.05±0.01) for 1 and logK'=(4.79±0.01) for 2. The analysis of time-domain fluorescence intensity decays confirmed both qualitatively and quantitatively the model used to describe the binding and competition processes. Cell studies indicated that apoptosis is the major mechanism of cell death for both complexes, with 2 (the more active complex) promoting that process more efficiently than 1. Transmission electron micrographs revealed clear alterations on intracellular organization consistent with the induction of programmed cell death processes.

  9. Catalytic reduction-adsorption for removal of p-nitrophenol and its conversion p-aminophenol from water by gold nanoparticles supported on oxidized mesoporous carbon.

    PubMed

    Guo, Pucan; Tang, Lin; Tang, Jing; Zeng, Guangming; Huang, Binbin; Dong, Haoran; Zhang, Yi; Zhou, Yaoyu; Deng, Yaocheng; Ma, Linlin; Tan, Shiru

    2016-05-01

    A highly efficient method for removal of p-nitrophenol and its conversion p-aminophenol from water was proposed using a novel catalyst-adsorbent composite of gold nanoparticles supported on functionalized mesoporous carbon (Au@CMK-3-O). The immobilized gold nanoparticles presented excellent catalytic ability to converse p-nitrophenol into p-aminophenol with the help of sodium borohydride, and the oxidized mesoporous carbon (CMK-3-O) serving as both carrier and adsorbent also exhibited high efficiency to remove p-aminophenol. The morphology and structure of the composite were characterized via SEM, TEM, FTIR and XPS analysis. Moreover, the mechanism of reaction process and the parameters of kinetics and thermodynamics were investigated. The activation energy was figured as 86.8 kJ mol(-1) for the adsorption and reduction of p-nitrophenol to p-aminophenol. The thermodynamic analysis based on the rate constants evaluated by pseudo-first-order model reveals that the adsorption-reduction process is an endothermic procedure with the rise of randomness. The anti-oxidation and regeneration study indicates that Au@CMK-3-O can be reused for 6 times with more than 90% conversion efficiency and keep high activity after exposing in air for 1 month, which possesses great prospects in application of nitroaromatic pollutant removal.

  10. Oxidation of 2-aminophenol to 2-amino-3H-phenoxazin-3-one with monochloramine in aqueous environment: A new method for APO synthesis?

    PubMed

    Abou Mehrez, Odissa; Dossier-Berne, Florence; Legube, Bernard

    2016-02-01

    Reaction of 2-aminophenol (2AP) with monochloramine in aqueous solution was investigated at pH 8.5 and 25 °C, with an excess of monochloramine. 2-Amino-3H-phenoxazin-3-one (APO) was the major product formed in about 70% yield. Despite low formation yields, adsorbable organic halides (AOX) were also formed over reaction time.

  11. Novel mixed ligand complexes of bioactive Schiff base (E)-4-(phenyl (phenylimino) methyl) benzene-1,3-diol and 2-aminophenol/2-aminobenzoic acid: Synthesis, spectral characterization, antimicrobial and nuclease studies

    NASA Astrophysics Data System (ADS)

    Subbaraj, P.; Ramu, A.; Raman, N.; Dharmaraja, J.

    2014-01-01

    A novel bidentate Schiff base ligand has been synthesized using 2,4-dihydroxybenzophenone and aniline. Its mixed ligand complexes of MAB type [M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II); HA = Schiff base and B = 2-aminophenol/2-aminobenzoic acid] have been synthesized and characterized on the basis of spectral data UV-Vis, IR, 1H NMR, FAB-Mass, EPR, SEM and magnetic studies. All the complexes were soluble in DMF and DMSO. Elemental analysis and molar conductance values indicate that the complexes are non-electrolytes. HA binds with M(II) ions through azomethine and deprotonated phenolic group and B binds through the primary amine group and deprotonated phenolic/carboxylic groups. Using FAB-Mass the cleavage pattern of the ligand (HA) has been established. All the complexes adopt octahedral geometry around the metal ions. It has been confirmed with the help of UV-Vis, IR, 1H NMR and FAB-Mass spectral data. DNA binding activities of the complexes 1d and 2d are studied by UV-Vis spectroscopy and cleavage studies of Schiff base ligand and its complexes 1d and 2d have been by agarose gel electrophoresis method. In vitro biological activities of the free ligand (HA) and their metal complexes (1a-1e and 2a-2e) were screened against few bacteria, Escherichia coli, Staphylococcus saphyphiticus, Staphylococcus aureus, Pseudomonas aeruginosa and fungi Aspergillus niger, Enterobacter species, Candida albicans by well diffusion technique.

  12. Chemometrics resolution and quantification power evaluation: Application on pharmaceutical quaternary mixture of Paracetamol, Guaifenesin, Phenylephrine and p-aminophenol

    NASA Astrophysics Data System (ADS)

    Yehia, Ali M.; Mohamed, Heba M.

    2016-01-01

    Three advanced chemmometric-assisted spectrophotometric methods namely; Concentration Residuals Augmented Classical Least Squares (CRACLS), Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) and Principal Component Analysis-Artificial Neural Networks (PCA-ANN) were developed, validated and benchmarked to PLS calibration; to resolve the severely overlapped spectra and simultaneously determine; Paracetamol (PAR), Guaifenesin (GUA) and Phenylephrine (PHE) in their ternary mixture and in presence of p-aminophenol (AP) the main degradation product and synthesis impurity of Paracetamol. The analytical performance of the proposed methods was described by percentage recoveries, root mean square error of calibration and standard error of prediction. The four multivariate calibration methods could be directly used without any preliminary separation step and successfully applied for pharmaceutical formulation analysis, showing no excipients' interference.

  13. Chemometrics resolution and quantification power evaluation: Application on pharmaceutical quaternary mixture of Paracetamol, Guaifenesin, Phenylephrine and p-aminophenol.

    PubMed

    Yehia, Ali M; Mohamed, Heba M

    2016-01-05

    Three advanced chemmometric-assisted spectrophotometric methods namely; Concentration Residuals Augmented Classical Least Squares (CRACLS), Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) and Principal Component Analysis-Artificial Neural Networks (PCA-ANN) were developed, validated and benchmarked to PLS calibration; to resolve the severely overlapped spectra and simultaneously determine; Paracetamol (PAR), Guaifenesin (GUA) and Phenylephrine (PHE) in their ternary mixture and in presence of p-aminophenol (AP) the main degradation product and synthesis impurity of Paracetamol. The analytical performance of the proposed methods was described by percentage recoveries, root mean square error of calibration and standard error of prediction. The four multivariate calibration methods could be directly used without any preliminary separation step and successfully applied for pharmaceutical formulation analysis, showing no excipients' interference.

  14. Synthesis and single crystal x-ray diffraction study of a Schiff base derived from 4-acylpyrazolone and 2-aminophenol

    SciTech Connect

    Sharma, Naresh; Kant, Rajni Gupta, Vivek K.; Jadeja, R. N.

    2014-04-24

    The title compound, (Z)-1-(3-chlorophenyl)-4[1((2hydroxyphenyl)amino)propylidene] -3-methyl-1H-pyrazol-5(4H)-one was synthesized by refluxing compound 1-(m-chlorophenyl)-3-methyl-4-propionyl-5-pyrazolone, with 2-aminophenol in ethanol. The compound crystallizes in the orthorhombic crystal system with space group Pca2{sub 1} having unit cell parameters: a = 26.2993(8), b = 7.0724(2) and c = 18.7170(5)Å. The structure contains two crystallographically independent molecules, A, and, B, in the asymmetric unit cell. The crystal structure was solved by direct method using single crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures to a final R- value of 0.049 for 5207 observed reflections.

  15. Monodisperse silica nanoparticles coated with gold nanoparticles as a sorbent for the extraction of phenol and dihydroxybenzenes from water samples based on dispersive micro-solid-phase extraction: Response surface methodology.

    PubMed

    Khezeli, Tahere; Daneshfar, Ali

    2015-08-01

    A selective and sensitive method was developed based on dispersive micro-solid-phase extraction for the extraction of hydroquinone, resorcinol, pyrocatechol and phenol from water samples prior to high-performance liquid chromatography with UV detection. SiO2 , SiO2 @MPTES, and SiO2 @MPTES@Au nanoparticles (MPTES = 3-mercaptopropyltriethoxysilane) were synthesized and characterized by scanning electronic microscopy, thermogravimetric analysis, differential thermogravimetric analysis, and infrared spectroscopy. Variables such as the amount of sorbent (mg), pH and ionic strength of sample the solution, the volume of eluent solvent (μL), vortex and ultrasonic times (min) were investigated by Plackett-Burman design. The significant variables optimized by a Box-Behnken design were combined by a desirability function. Under optimized conditions, the calibration graphs of phenol and dihydroxybenzenes were linear in a concentration range of 1-500 μg/L, and with correlation coefficients more than 0.995. The limits of detection for hydroquinone, resorcinol, pyrocatechol, and phenol were 0.54, 0.58, 0.46, and 1.24 μg/L, and the limits of quantification were 1.81, 1.93, 1.54, and 4.23 μg/L, respectively. This procedure was successfully employed to determine target analytes in spiked water samples; the relative mean recoveries ranged from 93.5 to 98.9%.

  16. An evaluation of Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) as a rescue agent for the nephropathy induced by uranyl fluoride (UO2F2) in rats

    SciTech Connect

    Zalups, R.K. )

    1991-04-01

    Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) was tested as a potential rescue agent for the nephropathy induced by uranyl fluoride (UO2F2) in rats. When uranyl fluoride was administered (i.v.) to male Sprague-Dawley rats at a dose that delivered 250 micrograms U/kg, moderate to severe cellular necrosis occurred in pars recta segments of proximal tubules in the cortex and outer stripe of the outer medulla of the rats' kidneys within four days after treatment. The severity of renal tubular injury was not significantly diminished when rats were given a 10, 100 or 1,000 mg/kg dose of Tiron (i.p.) 30 minutes after the administration of uranyl fluoride. No obvious protection was noted even when the rats were given a 1,000 mg/kg dose of Tiron 15, 30 and 90 minutes after the administration of uranyl fluoride. Therefore, Tiron does not appear to provide rats substantial protection against a dose of uranyl fluoride that induces moderate to severe renal injury.

  17. Economically applicable Ti2O3 decorated m-aminophenol-formaldehyde resin microspheres for dye-sensitized solar cells (DSSCs).

    PubMed

    Sasikumar, Ragu; Ranganathan, Palraj; Chen, Shen-Ming; Sireesha, Pedaballi; Chen, Tse-Wei; Veerakumar, Pitchaimani; Rwei, Syang-Peng; Kavitha, Thavuduraj

    2017-05-15

    In this present study, we focus on economically applicable polymeric material as photo-anode for dye-sensitized solar cells (DSSCs). Water droplets on grass like Ti2O3 decorated m-aminophenol-formaldehyde resin microspheres (mAPFR@Ti2O3) synthesized by surfactant-free and template-free hydrothermal method. The synthesized mAPFR@Ti2O3 material morphology was characterized by field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM). From that results, it was found in uniform arrangements with excellent thermal stability. As we know from the literature we are the first to report the mechanism about mAPFR microspheres formations. Owing to the low temperature processing, cheap cost and easy preparation in this current study we propose to use mAPFR@Ti2O3 microspheres as an active material for the preparation of doped photo-anode in DSSCs exhibited the short-circuit photocurrent density (Jsc) of 18.14mAcm(-2), open circuit voltage (Voc) of 0.70V, fill factor (FF) of 0.62, power conversion efficiency is 7.90% which is 84% greater than that of DSSCs with conventional TiO2 electrode.

  18. Degradation of 4-chloro 2-aminophenol using a novel combined process based on hydrodynamic cavitation, UV photolysis and ozone.

    PubMed

    Barik, Arati J; Gogate, Parag R

    2016-05-01

    The degradation of 4-chloro 2-aminophenol (4C2AP), an acute toxic organic compound, has been studied using different approaches based on the hydrodynamic cavitation (HC) with orifice plate as cavitating device, photolysis (UV) and ozonation (O3). The dependency of extent of degradation on operating parameters like operating pressure (2-5 bar), initial pH (3-8) and temperature (30-38 °C) have been established initially to maximize the efficacy of hydrodynamic cavitation. Subsequently the degradation has been studied using combined treatment strategies as HC+UV, HC+O3, UV+O3 and HC+UV+O3 at the established optimum parameters of operating temperature as 30 °C, initial pH of 6 and inlet pressure of 4 bar. The maximum extent of degradation as 96.85% and 73.6% reduction in TOC has been obtained using hydrodynamic cavitation in combination with UV photolysis and ozonation under the optimized operating conditions. The degradation products of 4C2AP have been identified using GC-MS. The present work has clearly established the efficacy of combined treatment approach (HC+UV+O3) for the removal of organic pollutant for the first time.

  19. Contribution of reactive oxygen species to para-aminophenol toxicity in LLC-PK{sub 1} cells

    SciTech Connect

    Foreman, Brooke D.; Tarloff, Joan B.

    2008-07-15

    para-aminophenol (PAP) causes nephrotoxicity by biochemical mechanisms that have not been fully elucidated. PAP can undergo enzymatic or non-enzymatic oxidation to form reactive intermediates. Using modulators of reactive oxygen species (ROS), the role of ROS in PAP toxicity in LLC-PK{sub 1} cells was investigated. ROS formation was determined using a fluorescein derivative and viability using alamarBlue. Following treatment of cells with PAP, ROS formation occurred prior to loss of cell viability. Several modulators of ROS were used to identify the pathways involved in PAP toxicity. Viability was improved with catalase treatment, while viability was decreased when cells were treated with superoxide dismutase (SOD). Both catalase and SOD exert their effects outside of cells in the incubation medium, since there was no evidence of uptake of these enzymes in LLC-PK{sub 1} cells. In cell-free incubations, hydrogen peroxide (H{sub 2}O{sub 2}) was produced when 0.5 mM PAP was included in the incubation medium. Further, SOD greatly increased and catalase greatly decreased H{sub 2}O{sub 2} production in these cell-free incubations. These data suggest that H{sub 2}O{sub 2} formed in the incubation medium contributes to loss of viability following PAP treatment. When cells were coincubated with 0.5 mM PAP and tiron, pyruvate, bathocuproine, 1, 10-phenanthroline, or dimethylthiourea (DMTU), ROS formation was decreased. However, there was minimal improvement in cell viability. Paradoxically, DMTU exacerbated PAP-induced loss of viability. These data suggest that ROS are generated in cells exposed to PAP but these species are not the predominant cause of cellular injury.

  20. Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.

    PubMed

    Ren, Jinwei; Liu, Dong; Tian, Li; Wei, Yangye; Proksch, Peter; Zeng, Jinzhang; Lin, Wenhan

    2013-01-01

    Five new phenoxazine-based alkaloids venezuelines A-E (1-5) and two new aminophenols venezuelines F-G (6-7), as well as three known analogues exfoliazone, chandrananimycin D and carboxyexfoliazone were isolated from the fermentation broth of the marine-derived bacterium Streptomyces venezuelae. The structures of new compounds were determined on the basis of extensive spectroscopic analysis. The cytotoxic activity of these compounds against a panel of tumor cell lines were tested, while the regulation of gene target Nur77 of 2 and exfoliazone (8) were evaluated.

  1. Determination of aminophenols and phenol in hair colorants by ultrasound-assisted solid-phase dispersion extraction coupled with ion chromatography.

    PubMed

    Zhong, Zhixiong; Li, Gongke; Wu, Rong; Zhu, Binghui; Luo, Zhibin

    2014-08-01

    A simple and reliable ultrasound-assisted solid-phase dispersion extraction coupled with ion chromatography was developed for the determination of aminophenols and phenol. The highly viscous hair colorant was dispersed in solvents using anhydrous sodium sulfite having dual functions of dispersant and antioxidant. The use of anhydrous sodium sulfite did not change the sample volume because it could completely dissolve in solution after matrix dispersion. The extraction and cleanup were combined in one single step for simplifying operation. The extraction process could be rapidly accomplished within 9 min with high sample throughput under the synergistic effects of vibration, ultrasound, and heating. Satisfactory linearity was observed with correlation coefficients higher than 0.9992, and the limits of detection varied from 0.02 to 0.09 mg/L. The applicability of the proposed method was demonstrated by measuring the concentrations of aminophenols and phenol in 32 different commercial hair color products. The recoveries ranged from 86.4-101.2% with the relative standard deviations in the range of 0.52-4.3%. The method offers an attractive alternative for the analysis of trace phenols in complex matrices.

  2. Permselective and enzyme-entrapping behaviours of an electropolymerized, non-conducting, poly(o-aminophenol) thin film-modified electrode: a critical study.

    PubMed

    Guerrieri, Antonio; Ciriello, Rosanna; Centonze, Diego

    2009-02-15

    Non-conducting polymeric films synthesised by the electrooxidation of o-aminophenol on a platinum electrode in acetate or phosphate buffer displayed an interesting permselective behaviour, which proved valuable in minimising the electrochemical interferences from ascorbate, acetaminophen, cysteine and urate sample molecules in amperometric detection mode. The electrosynthesis of poly(o-aminophenol) (p(oAP)) film showed also useful as permselective membrane for enzyme immobilization as demonstrated by the production of an interference-free glucose oxidase biosensor. In this respect, the glucose response time, t(0.95), evaluated in batch addition experiments, was lower than 5s while the calibration curve was linear up to 10mM of glucose with a sensitivity of 69.7nA/mM. Both the permselective behaviour and the enzyme-entrapping property of the film were critically compared with the relevant studies until now reported. With respect to the sophisticated but complex approaches described elsewhere, this study shows that simply a proper optimization of p(oAP) electrosynthesis and its permselective behaviour is the key to improve significantly the selectivity of the resulting analytical devices.

  3. Nickel-based xerogel catalysts: Synthesis via fast sol-gel method and application in catalytic hydrogenation of p-nitrophenol to p-aminophenol

    NASA Astrophysics Data System (ADS)

    Feng, Jin; Wang, Qiang; Fan, Dongliang; Ma, Lirong; Jiang, Deli; Xie, Jimin; Zhu, Jianjun

    2016-09-01

    In order to investigate the roles of three-dimensional network structure and calcium on Ni catalysts, the Ni, Ni-Al2O3, Ni-Ca-Al2O3 xerogel catalysts were successfully synthesized via the fast sol-gel process and chemical reduction method. The crystal structure of three different catalysts was observed with X-ray powder diffraction (XRD). Transmission electron microscopy (TEM), scanning electron microscopy (SEM) and nitrogen adsorption-desorption were employed to investigate the role of network structure of xerogel catalysts and the size distribution of Ni nanoparticles. The catalyst composition was determined by inductively coupled plasma-optical emission spectrometry (ICP-OES) measurement and energy-dispersive X-ray spectroscopy (EDS). Temperature-programmed reduction (TPR) experiments were carried out to investigate the reducibility of nickel species and the interaction between nickel species and alumina. The catalytic hydrogenation of p-nitrophenol to p-aminophenol was investigated over the prepared nickel-based xerogel catalysts. The conversion of p-nitrophenol was monitored by UV spectrophotometry and high performance liquid chromatography (HPLC). The results show that the catalysts are highly selective for the conversion of p-nitrophenol to p-aminophenol and the order of catalytic activities of the catalysts is Ni < Ni-Al2O3 < Ni-Ca-Al2O3. The catalysts were recycled and were used to evaluate the reutilization.

  4. Genomic and Functional Analyses of the 2-Aminophenol Catabolic Pathway and Partial Conversion of Its Substrate into Picolinic Acid in Burkholderia xenovorans LB400

    PubMed Central

    Agulló, Loreine; González, Myriam; Seeger, Michael

    2013-01-01

    2-aminophenol (2-AP) is a toxic nitrogen-containing aromatic pollutant. Burkholderia xenovorans LB400 possess an amn gene cluster that encodes the 2-AP catabolic pathway. In this report, the functionality of the 2-aminophenol pathway of B. xenovorans strain LB400 was analyzed. The amnRJBACDFEHG cluster located at chromosome 1 encodes the enzymes for the degradation of 2-aminophenol. The absence of habA and habB genes in LB400 genome correlates with its no growth on nitrobenzene. RT-PCR analyses in strain LB400 showed the co-expression of amnJB, amnBAC, amnACD, amnDFE and amnEHG genes, suggesting that the amn cluster is an operon. RT-qPCR showed that the amnB gene expression was highly induced by 2-AP, whereas a basal constitutive expression was observed in glucose, indicating that these amn genes are regulated. We propose that the predicted MarR-type transcriptional regulator encoded by the amnR gene acts as repressor of the amn gene cluster using a MarR-type regulatory binding sequence. This report showed that LB400 resting cells degrade completely 2-AP. The amn gene cluster from strain LB400 is highly identical to the amn gene cluster from P. knackmussi strain B13, which could not grow on 2-AP. However, we demonstrate that B. xenovorans LB400 is able to grow using 2-AP as sole nitrogen source and glucose as sole carbon source. An amnBA− mutant of strain LB400 was unable to grow with 2-AP as nitrogen source and glucose as carbon source and to degrade 2-AP. This study showed that during LB400 growth on 2-AP this substrate was partially converted into picolinic acid (PA), a well-known antibiotic. The addition of PA at lag or mid-exponential phase inhibited LB400 growth. The MIC of PA for strain LB400 is 2 mM. Overall, these results demonstrate that B. xenovorans strain LB400 posses a functional 2-AP catabolic central pathway, which could lead to the production of picolinic acid. PMID:24124510

  5. Electrochemical Detection of p-Aminophenol by Flexible Devices Based on Multi-Wall Carbon Nanotubes Dispersed in Electrochemically Modified Nafion

    PubMed Central

    Scandurra, Graziella; Antonella, Arena; Ciofi, Carmine; Saitta, Gaetano; Lanza, Maurizio

    2014-01-01

    A conducting composite prepared by dispersing multi-walled carbon nanotubes (MWCNTs) into a host matrix consisting of Nafion, electrochemically doped with copper, has been prepared, characterized and used to modify one of the gold electrodes of simply designed electrochemical cells having copier grade transparency sheets as substrates. Electrical measurements performed in deionized water show that the Au/Nafion/Au-MWCNTs–Nafion:Cu cells can be successfully used in order to detect the presence of p-aminophenol (PAP) in water, without the need for any supporting electrolyte. The intensity of the redox peaks arising when PAP is added to deionized water is found to be linearly related to the analyte in the range from 0.2 to 1.6 μM, with a detection limit of 90 nM and a sensitivity of 7 μA·(μM−1)·cm−2. PMID:24854357

  6. Electrochemical detection of p-aminophenol by flexible devices based on multi-wall carbon nanotubes dispersed in electrochemically modified Nafion.

    PubMed

    Scandurra, Graziella; Antonella, Arena; Ciofi, Carmine; Saitta, Gaetano; Lanza, Maurizio

    2014-05-21

    A conducting composite prepared by dispersing multi-walled carbon nanotubes (MWCNTs) into a host matrix consisting of Nafion, electrochemically doped with copper, has been prepared, characterized and used to modify one of the gold electrodes of simply designed electrochemical cells having copier grade transparency sheets as substrates. Electrical measurements performed in deionized water show that the Au/Nafion/Au-MWCNTs-Nafion:Cu cells can be successfully used in order to detect the presence of p-aminophenol (PAP) in water, without the need for any supporting electrolyte. The intensity of the redox peaks arising when PAP is added to deionized water is found to be linearly related to the analyte in the range from 0.2 to 1.6 µM, with a detection limit of 90 nM and a sensitivity of 7 µA·(µM(-1))·cm(-2).

  7. Asymmetric PTC C-alkylation catalyzed by chiral derivatives of tartaric acid and aminophenols. Synthesis Of (R)- and (S)-alpha-methyl amino acids

    PubMed

    Belokon; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Singh; Parmar; Vyskocil; Kagan

    2000-10-20

    A new type of efficient chiral catalyst has been elaborated for asymmetric C-alkylation of CH acids under PTC conditions. Sodium alkoxides formed from chiral derivatives of tartaric acid and aminophenols (TADDOL's 2a-e and NOBIN's 3a-h) can be used as chiral catalysts in the enantioselective alkylation, as exemplified by the reaction of Schiff's bases 1a-e derived from alanine esters and benzaldehydes with active alkyl halides. Acid-catalyzed hydrolysis of the products formed in the reaction afforded (R)-alpha-methylphenylalanine, (R)-alpha-naphthylmethylalanine, and (R)-alpha-allylalanine in 61-93% yields and with ee 69-93%. The procedure could be successfully scaled up to 6 g of substrate 1b. When (S,S)-TADDOL or (R)-NOBIN are used, the (S)-amino acids are formed. A mechanism rationalizing the observed features of the reaction has been suggested.

  8. Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4-aminophenol, 4'-chloroacetanilide, and p-chlorophenol in pharmaceutical preparations by high-performance liquid chromatography.

    PubMed

    Ali, Mohammed Shahid; Rafiuddin, Syed; Ghori, Mohsin; Kahtri, Aamer Roshanali

    2007-01-01

    This paper presents a simple, specific, and precise high-performance liquid chromatographic method for the simultaneous determination of paracetamol (PCM), chlorzoxazone (CXZ), and their related impurities in bulk raw materials and solid dosage forms. The mobile phase consisted of water-methanol-glacial acetic acid (60 + 40 + 2, v/v/v). A column containing octadecylsilane chemically bonded to porous silica particles (Spherisorb ODS 1, 25 cm x 4.6 mm, 5 microm) was used as stationary phase. Detection was performed using a variable wavelength ultraviolet-visible detector set at 272 nm for all compounds. Solutions were injected into the chromatograph under isocratic condition at a constant flow rate of 1.2 mL/min. The method was validated according to International Conference on Harmonization requirements and demonstrates good accuracy and precision and a wide linearity range. The method separates PCM, CXZ, and 3 major impurities [4-aminophenol (4AP), 4'-chloracetanilide (4CA), and p-chlorophenol (PCP)] with fair resolution in less than 15 min. The developed method is rapid and sensitive (limit of detection for 4AP, 4CA, and PCP established at 31.25, 39.06, and 65.16 ng/mL, respectively) and, therefore, suitable for quality control and stability studies of these compounds in dosage forms.

  9. Simultaneous analysis of acetaminophen, p-aminophenol and aspirin metabolites by hydrophilic interaction and strong anion exchange capillary liquid chromatography coupled to amperometric detection.

    PubMed

    Zheng, Minmin; Wu, Yimin; Lu, Lanxiang; Ding, Kang; Tang, Fengxiang; Lin, Zian; Wu, Xiaoping

    2011-08-01

    A simple and sensitive method has been developed for the simultaneous determination of polar nonsteroidal pharmaceuticals and metabolites, including acetaminophen, p-aminophenol and several aspirin metabolites (salicylic acid, gentisic acid, salicyluric acid and 2,3-dihydroxybenzoic acid), by capillary liquid chromatography with amperometric detection. Using a capillary monolithic column with mixed mode stationary phases and a mobile phase composed of acetonitrile and Tris buffer, rapid separation of six polar analytes was achieved within 8 min, and a hydrophilic interaction and strong anion exchange separation mechanism were exhibited. Method detection limits of six analytes ranged from 10 to 50 ng/mL. In terms of precision, the intra- and interday relative standard deviation values in all analytes never exceeded 3.1% for migration time and 8.9% for peak areas, respectively. This method provided a simple, rapid and cost-effective approach for the analysis of polar pharmaceuticals. The applicability of the method in pharmacokinetics was verified by spiking human serum samples with the compounds and analyzing the recoveries.

  10. A Dynamic Electrode for the Estimation of Praseodymium(III) using 1,5-Bis-(o-aminophenol)-3-thiapentane as an Ionophore.

    PubMed

    Singh, Sanjay; Rani, Geeta

    2012-03-01

    This study is related with the development of Pr3+ selective membrane sensor using 1,5-Bis-(o-aminophenol)-3-thiapentane as a neutral carrier. The sensor with membrane composition of 33% PVC, 54%, o-NPOE, 8% NaTPB and 5% ionophore, exhibits a Nernstian response for Pr3+ ion, with a wide concentration range of 3.0 × 10-9-1.0 × 10-2 mol/L, low detection limit (1.0 × 10-9 mol/L) and slope of 23.50.3mV decade-1 of activity with in pH range of 2.0-8.8 and fast response time of 7s. The sensor was also found to work satisfactorily in partially non-aqueous media up to 25% (v/v) content of methanol, ethanol or acetone and could be used for a period of 8 months without any change in response characteristics. The proposed membrane electrode was successfully applied as an indicator electrode for the titration of Pr3+ ion (1.0 × 10-3 M) with a standard EDTA solution (1.0 × 10-3 M).

  11. A simple synthesis of nitrogen doped porous graphitic carbon: Electrochemical determination of paracetamol in presence of ascorbic acid and p-aminophenol.

    PubMed

    Biswas, Sudip; Chakraborty, Dipanjan; Das, Rashmita; Bandyopadhyay, Rajib; Pramanik, Panchanan

    2015-08-26

    Graphite paste electrode modified with nitrogen doped porous carbon (NDPC) is used for the detections of paracetamol (PCM), ascorbic acid (AA) and p-aminophenol (PAP) at relatively low concentration. NDPC is synthesized by direct carbonization of Zn(OAc)2 incorporated melamine-formaldehyde resin microsphere. The NDPC shows small pore diameters centered at 3.14 nm and 8.12 nm and has a pseudo graphitic structure with reasonable porous matrix. The lower limit of detections (S/N = 3) for PCM, AA, and PAP are found to be 30 nM, 720 nM and 10 nM respectively. Under optimized experimental condition, the linear ranges of determination for PCM and AA are 1-400 μM, 10-2700 μM respectively in mixture. Similarly for PCM and PAP mixture, the linear ranges of determination are found to be 1-90 μM. It is also used for the analysis of urine and pharmaceutical products with better sensitivity.

  12. Highly sensitive sequential injection determination of p-aminophenol in paracetamol formulations with 18-molybdodiphosphate heteropoly anion based on elimination of Schlieren effect.

    PubMed

    Vishnikin, Andriy B; Al-Shwaiyat, Mohammed K E A; Petrushina, Galina A; Tsiganok, Ludmila P; Andruch, Vasil; Bazel, Yaroslav R; Sklenářová, Hana; Solich, Petr

    2012-07-15

    A highly sensitive, precise and automated method using sequential injection analysis to assay quantitatively low levels of the p-aminophenol (PAP) in paracetamol formulations has been developed. A solution containing PAP and paracetamol is injected into an acetate buffer carrier stream and merged on-line with 18-molybdodiphosphate heteropoly complex reagent to form a specific blue derivative that is subsequently detected spectrophotometrically at 820nm. The procedure has been optimized mainly with respect to measurement sensitivity. It is based on the leveling off of the refraction indices of the liquids mixed in the flow system by the careful matching of the refractive index of the reagent solution with that of the carrier and sample solutions. Amount as low as 0.5μmolL(-1) of PAP, which corresponds to the 0.001% of PAP in paracetamol tablets, can be reliably determined using the proposed method, which is clearly below the specification limits recommended for PAP determination in paracetamol drug and tablet formulations (50ppm or 0.005% (w/w)). The developed method was successfully applied to the analysis of paracetamol formulations spiked with PAP and determination of PAP content in Rapidol tablets past their expiration date both by proposed SIA and reference HPLC methods.

  13. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

    PubMed Central

    Xie, Yuchao; McGill, Mitchell R.; Du, Kuo; Dorko, Kenneth; Kumer, Sean C.; Schmitt, Timothy M.; Ding, Wen-Xing; Jaeschke, Hartmut

    2015-01-01

    3′-Hydroxyacetanilide or N-acetyl-meta-aminophenol (AMAP) is generally regarded as a non-hepatotoxic analog of acetaminophen (APAP). Previous studies demonstrated absence of toxicity after AMAP in mice, hamsters, primary mouse hepatocytes and several cell lines. In contrast, experiments with liver slices suggested that it may be toxic to human hepatocytes; however, the mechanism of toxicity is unclear. To explore this, we treated primary human hepatocytes (PHH) with AMAP or APAP for up to 48 h and measured several parameters to assess metabolism and injury. Although less toxic than APAP, AMAP dose-dependently triggered cell death in PHH as indicated by alanine aminotransferase (ALT) release and propidium iodide (PI) staining. Similar to APAP, AMAP also significantly depleted glutathione (GSH) in PHH and caused mitochondrial damage as indicated by glutamate dehydrogenase (GDH) release and the JC-1 assay. However, unlike APAP, AMAP treatment did not cause relevant c-jun-N-terminal kinase (JNK) activation in the cytosol or phospho-JNK translocation to mitochondria. To compare, AMAP toxicity was assessed in primary mouse hepatocytes (PMH). No cytotoxicity was observed as indicated by the lack of lactate dehydrogenase release and no PI staining. Furthermore, there was no GSH depletion or mitochondrial dysfunction after AMAP treatment in PMH. Immunoblotting for arylated proteins suggested that AMAP treatment caused extensive mitochondrial protein adducts formation in PHH but not in PMH. In conclusion, AMAP is hepatotoxic in PHH and the mechanism involves formation of mitochondrial protein adducts and mitochondrial dysfunction. PMID:26431796

  14. Artificial neural network assisted kinetic spectrophotometric technique for simultaneous determination of paracetamol and p-aminophenol in pharmaceutical samples using localized surface plasmon resonance band of silver nanoparticles

    NASA Astrophysics Data System (ADS)

    Khodaveisi, Javad; Dadfarnia, Shayessteh; Haji Shabani, Ali Mohammad; Rohani Moghadam, Masoud; Hormozi-Nezhad, Mohammad Reza

    2015-03-01

    Spectrophotometric analysis method based on the combination of the principal component analysis (PCA) with the feed-forward neural network (FFNN) and the radial basis function network (RBFN) was proposed for the simultaneous determination of paracetamol (PAC) and p-aminophenol (PAP). This technique relies on the difference between the kinetic rates of the reactions between analytes and silver nitrate as the oxidizing agent in the presence of polyvinylpyrrolidone (PVP) which is the stabilizer. The reactions are monitored at the analytical wavelength of 420 nm of the localized surface plasmon resonance (LSPR) band of the formed silver nanoparticles (Ag-NPs). Under the optimized conditions, the linear calibration graphs were obtained in the concentration range of 0.122-2.425 μg mL-1 for PAC and 0.021-5.245 μg mL-1 for PAP. The limit of detection in terms of standard approach (LODSA) and upper limit approach (LODULA) were calculated to be 0.027 and 0.032 μg mL-1 for PAC and 0.006 and 0.009 μg mL-1 for PAP. The important parameters were optimized for the artificial neural network (ANN) models. Statistical parameters indicated that the ability of the both methods is comparable. The proposed method was successfully applied to the simultaneous determination of PAC and PAP in pharmaceutical preparations.

  15. Hydrogenation of 4-nitrophenol to 4-aminophenol at room temperature: Boosting palladium nanocrystals efficiency by coupling with copper via liquid phase pulsed laser ablation

    NASA Astrophysics Data System (ADS)

    Park, Hanbit; Reddy, D. Amaranatha; Kim, Yujin; Lee, Seunghee; Ma, Rory; Lim, Manho; Kim, Tae Kyu

    2017-04-01

    Ultra-dispersed bimetallic nanomaterials have attracted much attention in the hydrogenation of highly toxic aromatic nitro compounds to aromatic amines owing to their high stability, superior activity, reusability, and unique optical and electronic properties, as compared to monometalic nanocrystals. However, the lack of facile and economically controllable strategies of producing highly pure ultra-dispersed bimetallic nanocatalysts limits their practical industrial applications. Considering the above obstacles, we present a simple and effective strategy for the formation of bimetallic (PdCu) nanocrystals by liquid phase pulsed laser ablation using a bulk Pd metal plate submerged in CuCl2 solutions with different concentrations, in contrast to the complex and costly experimental methods used previously. The microstructural and optical properties of the synthesized nanocrystals indicate that the obtained bimetallic nanostructures are highly pure and monodispersed. Moreover, bimetallic PdCu nanostructures show a higher catalytic activity than monometallic Pd nanocrystals for the hydrogenation of 4-nitrophenol to 4-aminophenol at room temperature, also exhibiting high stability for up to four recycles. The mechanism of the enhanced catalytic activity and stability of bimetallic nanocrystals is discussed in detail. Finally, we believe that the presented design strategy and utilization of bimetallic nanocrystals for catalytic applications enables the development of novel bimetallic nanostructures by liquid phase pulsed laser ablation and their catalytic application for environmental remediation.

  16. Surface Molecular Imprinting on Silica-Coated CdTe Quantum Dots for Selective and Sensitive Fluorescence Detection of p-aminophenol in Water.

    PubMed

    Lu, Xialin; Wei, Fangdi; Xu, Guanhong; Wu, Yanzi; Yang, Jing; Hu, Qin

    2017-01-01

    In this paper, a selective and sensitive sensor for the determination of p-aminophenol (PAP) was developed by grafting molecularly imprinted polymers (MIPs) on the surface of silica-coated CdTe quantum dots (CdTe@SiO2@MIPs). The obtained CdTe@SiO2@MIPs were characterized by X-ray powder diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy and fluorescence spectroscopy. The fluorescence intensity of CdTe@SiO2@MIPs was more strongly quenched by PAP than that of the structural analogues of PAP. Under the optimal conditions, the fluorescence intensity of the CdTe@SiO2@MIPs decreased sensitively with the increase of PAP concentration in the range of 0.05-50 μM. The limit of detection was 0.02 μM (3σ/K sv). The sensor was successfully used to determine PAP in tap and lake water samples, and the average recoveries of PAP at various spiking levels ranged from 97.33 % to 103.3 % with relative standard deviations below 20 %.

  17. Skin metabolism of aminophenols: Human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo

    SciTech Connect

    Goebel, C. Hewitt, N.J.; Kunze, G.; Wenker, M.; Hein, D.W.; Beck, H.; Skare, J.

    2009-02-15

    4-Amino-2-hydroxytolune (AHT) is an aromatic amine ingredient in oxidative hair colouring products. As skin contact occurs during hair dyeing, characterisation of dermal metabolism is important for the safety assessment of this chemical class. We have compared the metabolism of AHT in the human keratinocyte cell line HaCaT with that observed ex-vivo in human skin and in vivo (topical application versus oral (p.o.) and intravenous (i.v.) route). Three major metabolites of AHT were excreted, i.e. N-acetyl-AHT, AHT-sulfate and AHT-glucuronide. When 12.5 mg/kg AHT was applied topically, the relative amounts of each metabolite were altered such that N-acetyl-AHT product was the major metabolite (66% of the dose in comparison with 37% and 32% of the same applied dose after i.v. and p.o. administration, respectively). N-acetylated products were the only metabolites detected in HaCaT cells and ex-vivo whole human skin discs for AHT and p-aminophenol (PAP), an aromatic amine known to undergo N-acetylation in vivo. Since N-acetyltransferase 1 (NAT1) is the responsible enzyme, kinetics of AHT was further compared to the standard NAT1 substrate p-aminobenzoic acid (PABA) in the HaCaT model revealing similar values for K{sub m} and V{sub max}. In conclusion NAT1 dependent dermal N-acetylation of AHT represents a 'first-pass' metabolism effect in the skin prior to entering the systemic circulation. Since the HaCaT cell model represents a suitable in vitro assay for addressing the qualitative contribution of the skin to the metabolism of topically-applied aromatic amines it may contribute to a reduction in animal testing.

  18. Understanding natural semiquinone radicals--multifrequency EPR and relativistic DFT studies of the structure of Hg(II) complexes.

    PubMed

    Witwicki, Maciej; Jerzykiewicz, Maria; Ozarowski, Andrzej

    2015-01-01

    Multifrequency EPR spectroscopy and DFT calculations were used to investigate Hg(II) complexes with semiquinone radical ligands formed in a direct reaction between the metal ions and tannic acid (a polyphenol closely related to tannins). Because of the intricate structure of tannic acid a vast array of substituted phenolic compounds were tested to find a structural model mimicking its ability to react with Hg(II) ions. The components of the g matrix (the g tensor) determined from the high field (208 GHz) EPR spectra of the Hg(II) complexes with the radical ligands derived from tannic acid and from the model compounds were analogous, indicating a similar coordination mode in all the studied Hg(II) complexes. Since catechol (1,2-dihydroxybenzene) was the simplest compound undergoing the reaction with Hg(II) it was selected for DFT studies which were aimed at providing an insight into the structural properties of the investigated complexes. Various coordination numbers and different conformations and protonation states of the ligands were included in the theoretical analyses. g Matrices were computed for all the DFT optimized geometries. A good agreement between the theoretical and experimental values was observed only for the model with the Hg(II) ion tetracoordinated by two ligands, one of the ligands being monoprotonated with the unpaired electron mainly localized on it.

  19. Reversible Redox Chemistry and Catalytic C(sp(3))-H Amination Reactivity of a Paramagnetic Pd Complex Bearing a Redox-Active o-Aminophenol-Derived NNO Pincer Ligand.

    PubMed

    Broere, Daniël L J; van Leest, Nicolaas P; de Bruin, Bas; Siegler, Maxime A; van der Vlugt, Jarl Ivar

    2016-09-06

    The synthesis, spectroelectrochemical characterization (ultraviolet-visible and nuclear magnetic resonance), solid state structures, and computational metric parameters of three isostructural PdCl(NNO) complexes 1 [PdCl(NNO(ISQ))], 2 {[PdCl(NNO(AP))](-)}, and 5 {[PdCl(NNO(IBQ))](+)} (NNO = o-aminophenol-derived redox-active ligand with a pendant pyridine) with different NNO oxidation states are described. The reduced diamagnetic complex 2 readily reacts with halogenated solvents, including lattice solvent from crystalline pure material, as supported by spectroscopic data and density functional theory calculations. Thorough removal of chlorinated impurities allows for modest catalytic turnover in the conversion of 4-phenylbutyl azide into N-protected 2-phenylpyrrolidine, which is the first example of a palladium-catalyzed radical-type transformation facilitated by a redox-active ligand as well as the first C-H amination mediated by ligand-to-substrate single-electron transfer.

  20. Doped copolymer of polyanthranilic acid and o-aminophenol (AA-co-OAP): Synthesis, spectral characterization and the use of the doped copolymer as precursor of α-Fe2O3 nanoparticles

    NASA Astrophysics Data System (ADS)

    Hosny, Nasser Mohammed; Nowesser, Nourhan; Al-Hussaini, A. S.; Zoromba, Mohamed Shafick

    2016-02-01

    The copolymer of anthranilic acid and o-aminophenol (AA-co-OAP) was synthesized and characterized by IR, UV-Vis. and thermal analyses (TGA). Linear chain mode was suggested for the pure (AA-co-OAP). The effect of inclusion of MnCl2, CoCl2, NiCl2, CuCl2 and FeCl3 on the spectral, thermal and optical properties of AA-co-OAP has been studied. Octahedral stereochemistry was suggested for Fe, Mn and Ni doped AA-co-OAP, while tetrahedral and square-planar geometries were suggested for Co and Cu doped AA-co-OAP, respectively. Fe doped AA-co-OAP has been used as a precursor for α-Fe2O3 nanoparticles by thermal decomposition route at 800 °C. The obtained hematite has been characterized by XRD and TEM. The average size of the prepared nanoparticles was estimated as 34 nm. The optical band gap of the synthesized hematite nanoparticles was measured and compared with the bulk.

  1. Photobilirubin II.

    PubMed Central

    Bonnett, R; Buckley, D G; Hamzetash, D; Hawkes, G E; Ioannou, S; Stoll, M S

    1984-01-01

    An improved preparation of photobilirubin II in ammoniacal methanol is described. Evidence is presented which distinguishes between the two structures proposed earlier for photobilirubin II in favour of the cycloheptadienyl structure. Nuclear-Overhauser-enhancement measurements with bilirubin IX alpha and photobilirubin II in dimethyl sulphoxide are complicated by the occurrence of negative and zero effects. The partition coefficient of photobilirubin II between chloroform and phosphate buffer (pH 7.4) is 0.67. PMID:6743241

  2. Synthesis, characterization and catalytic activity of copper(II) complexes containing a redox-active benzoxazole iminosemiquinone ligand.

    PubMed

    Balaghi, S Esmael; Safaei, Elham; Chiang, Linus; Wong, Edwin W Y; Savard, Didier; Clarke, Ryan M; Storr, Tim

    2013-05-21

    A tridentate benzoxazole-containing aminophenol ligand HL(BAP) was synthesized and complexed with Cu(II). The resulting Cu(II) complexes were characterized by X-ray, IR, UV-vis-NIR spectroscopies, and magnetic susceptibility studies, demonstrating that the ligand is oxidized to the o-iminosemiquinone form [L(BIS)](-) in the isolated complexes. L(BIS)Cu(II)Cl exhibits a distorted tetrahedral geometry, while L(BIS)Cu(II)OAc is square pyramidal. In both solid state structures the ligand is coordinated to Cu(II)via the benzoxazole, as well as the nitrogen and oxygen atoms from the o-iminosemiquinone moiety. The chloride, or acetate group occupies the fourth and/or fifth positions in L(BIS)Cu(II)Cl and L(BIS)Cu(II)OAc, respectively. Magnetic susceptibility measurements indicate that both complexes are diamagnetic due to antiferromagnetic coupling between the d(9) Cu(II) centre and iminosemiquinone ligand radical. Electrochemical studies of the complexes demonstrate both a quasi-reversible reduction and oxidation process for the Cu complexes. While L(BIS)Cu(II)X (X = Cl) is EPR-silent, chemical oxidation affords a species with an EPR signal consistent with ligand oxidation to form a d(9) Cu(II) iminoquinone species. In addition, chemical reduction results in a Cu(II) centre most likely bound to an amidophenoxide. Mild and efficient oxidation of alcohol substrates to the corresponding aldehydes was achieved with molecular oxygen as the oxidant and L(BIS)Cu(II)X-Cs2CO3 as the catalyst.

  3. Synthesis, Spectral Characterization, SEM, Antimicrobial, Antioxidative Activity Evaluation, DNA Binding and DNA Cleavage Investigation of Transition Metal(II) Complexes Derived from a tetradentate Schiff base bearing thiophene moiety.

    PubMed

    Abdel Aziz, Ayman A; Seda, Sabry H

    2017-03-01

    A novel series of Co(II), Ni(II), Cu(II) and Zn(II) mononuclear complexes have been synthesized involving a potentially tetradentate Schiff base ligand, which was obtained by condensation of 2-aminophenol with 2,5-thiophene-dicarboxaldehyde. The complexes were synthesized via reflux reaction of methanolic solution of the appropriate Schiff base ligand with one equivalent of corresponding metal acetate salt. Based on different techniques including micro analysis, FT-IR, NMR, UV-Vis, ESR, ESI-mass and conductivity measurements, four-coordinated geometry was assigned for all complexes. Spectroscopic data have shown that, the reported Schiff base coordinated to metal ions as a dibasic tetradentate ligand through the phenolic oxygen and the azomethine nitrogen. The antimicrobial activities of the parent ligand and its complexes were investigated by using the agar disk diffusion method. Antioxidation properties of the novel complexes were investigated and it was found that all the complexes have good radical scavenging properties. The binding of complexes to calf thymus DNA (CT-DNA) was investigated by absorption, emission and viscosity measurements. Binding studies have shown that all the complexes interacted with CT-DNA via intercalation mode and the binding affinity varies with relative order as Cu(II) complex > Co(II) complex > Zn(II) complex > Ni(II) complex. Furthermore, DNA cleavage properties of the metal complexes were also investigated. The results suggested the possible utilization of novel complexes for pharmaceutical applications.

  4. Photosystem II

    ScienceCinema

    James Barber

    2016-07-12

    James Barber, Ernst Chain Professor of Biochemistry at Imperial College, London, gives a BSA Distinguished Lecture titled, "The Structure and Function of Photosystem II: The Water-Splitting Enzyme of Photosynthesis."

  5. Biological Synthesis of Substituted o-Aminophenols

    DTIC Science & Technology

    1991-02-01

    SUBJECT TERMS (Continue on reve:e ;f ne.ezjry an ,der-,y Zq block -.. alnber) FIELD GROUP SUB-GROUP Biology, polymer synthesis, specialty materials , 06...for Neurospora crassa tyrosinase was developed. This procedure simply involves pulverizing the frozen mycelium into a powder, suspension 3 of that...alkalescens, the nitro-reductase seems3to consist essentially of hydrogenase and a ferrodoxin-like material that can be separated from each other by Sephadex G

  6. Synthesis and magnetic properties of a new family of macrocyclic M(II)3Ln(III) complexes: insights into the effect of subtle chemical modification on single-molecule magnet behavior.

    PubMed

    Feltham, Humphrey L C; Clérac, Rodolphe; Ungur, Liviu; Vieru, Veacheslav; Chibotaru, Liviu F; Powell, Annie K; Brooker, Sally

    2012-10-15

    Thirteen tetranuclear mixed-metal complexes of the hexaimine macrocycle (L(Pr))(6-) have been prepared in a one-pot 3:1:3:3 reaction of copper(II) acetate hydrate, the appropriate lanthanide(III) nitrate hydrate, 1,4-diformyl-2,3-dihydroxybenzene (1), and 1,3-diaminopropane. The resulting family of copper(II)-lanthanide(III) macrocyclic complexes has the general formula Cu(II)(3)Ln(III)(L(Pr))(NO(3))(3)·solvents (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Tb, Ho, Er, Tm, or Yb). X-ray crystal structure determinations carried out on [Cu(3)Ce(L(Pr))(NO(3))(3)(MeOH)(3)] and [Cu(3)Dy(L(Pr))(NO(3))(3)(MeOH)(3)] confirmed that the large Ln(III) ion is bound in the central O(6) site and the three square pyramidal Cu(II) ions in the outer N(2)O(2) sites (apical donor either nitrate anion or methanol molecule) of the Schiff base macrocycle. Only the structurally characterized Cu(3)Tb complex, reported earlier, is a single-molecule magnet (SMM): the other 12 complexes do not exhibit an out-of-phase ac susceptibility signal or hysteresis of magnetization in a dc field. Ab initio calculations allowed us to rationalize the observed magnetic properties, including the significant impact of subtle chemical modification on SMM behavior. Broken-symmetry density functional theory (BS-DFT) calculations show there is a subtle structural balance as to whether the Cu···Cu exchange coupling is ferro- or antiferromagnetic. Of the family of 13 magnetically characterized tetranuclear Cu(II)(3)Ln(III) macrocyclic complexes prepared, only the Tb(III) complex is an SMM: the theoretical reasons for this are discussed.

  7. FAQs II

    ERIC Educational Resources Information Center

    Kezar, Adrianna; Frank, Vikki; Lester, Jaime; Yang, Hannah

    2008-01-01

    In their paper entitled "Why should postsecondary institutions consider partnering to offer (Individual Development Accounts (IDAs)?" the authors reviewed frequently asked questions they encountered from higher education professionals about IDAs, but as their research continued so did the questions. FAQ II has more in-depth questions and…

  8. SAGE II

    Atmospheric Science Data Center

    2016-02-16

    ... of stratospheric aerosols, ozone, nitrogen dioxide, water vapor and cloud occurrence by mapping vertical profiles and calculating ... (i.e. MLS and SAGE III versus HALOE) Fixed various bugs Details are in the  SAGE II V7.00 Release Notes .   ...

  9. Gamma II

    NASA Astrophysics Data System (ADS)

    Barker, Thurburn; Castelaz, M.; Cline, J.; Owen, L.; Boehme, J.; Rottler, L.; Whitworth, C.; Clavier, D.

    2011-05-01

    GAMMA II is the Guide Star Automatic Measuring MAchine relocated from STScI to the Astronomical Photographic Data Archive (APDA) at the Pisgah Astronomical Research Institute (PARI). GAMMA II is a multi-channel laser-scanning microdensitometer that was used to measure POSS and SERC plates to create the Guide Star Catalog and the Digital Sky Survey. The microdensitometer is designed with submicron accuracy in x and y measurements using a HP 5507 laser interferometer, 15 micron sampling, and the capability to measure plates as large as 0.5-m across. GAMMA II is a vital instrument for the success of digitizing the direct, objective prism, and spectra photographic plate collections in APDA for research. We plan several targeted projects. One is a collaboration with Drs. P.D. Hemenway and R. L. Duncombe who plan to scan 1000 plates of 34 minor planets to identify systematic errors in the Fundamental System of celestial coordinates. Another is a collaboration with Dr. R. Hudec (Astronomical Institute, Academy of Sciences of the Czech Republic) who is working within the Gaia Variability Unit CU7 to digitize objective prism spectra on the Henize plates and Burrell-Schmidt plates located in APDA. These low dispersion spectral plates provide optical counterparts of celestial high-energy sources and cataclysmic variables enabling the simulation of Gaia BP/RP outputs. The astronomical community is invited to explore the more than 140,000 plates from 20 observatories now archived in APDA, and use GAMMA II. The process of relocating GAMMA to APDA, re-commissioning, and starting up the production scan programs will be described. Also, we will present planned research and future upgrades to GAMMA II.

  10. PORT II

    NASA Technical Reports Server (NTRS)

    Muniz, Beau

    2009-01-01

    One unique project that the Prototype lab worked on was PORT I (Post-landing Orion Recovery Test). PORT is designed to test and develop the system and components needed to recover the Orion capsule once it splashes down in the ocean. PORT II is designated as a follow up to PORT I that will utilize a mock up pressure vessel that is spatially compar able to the final Orion capsule.

  11. PESTICINS II. I and II

    PubMed Central

    Brubaker, Robert R.; Surgalla, Michael J.

    1962-01-01

    Brubaker, Robert R. (Fort Detrick, Frederick, Md.) and Michael J. Surgalla. Pesticins. II. Production of pesticin I and II. J. Bacteriol. 84:539–545. 1962.—Pesticin I was separated from pesticin I inhibitor by ion-exchange chromatography of cell-free culture supernatant fluids and by acid precipitation of soluble preparations obtained from mechanically disrupted cells. The latter procedure resulted in formation of an insoluble pesticin I complex which, upon removal by centrifugation and subsequent dissolution in neutral buffer, exhibited a 100- to 1,000-fold increase in antibacterial activity over that originally observed. However, activity returned to the former level upon addition of the acid-soluble fraction, which contained pesticin I inhibitor. Since the presence of pesticin I inhibitor leads to serious errors in the determination of pesticin I, an assay medium containing ethylenediaminetetraacetic acid in excess Ca++ was developed; this medium eliminated the effect of the inhibitor. By use of the above medium, sufficient pesticin I was found to be contained within 500 nonirradiated cells to inhibit growth of a suitable indicator strain; at least 107 cells were required to effect a corresponding inhibition by pesticin II. Although both pesticins are located primarily within the cell during growth, pesticin I may arise extracellularly during storage of static cells. Slightly higher activity of pesticin I inhibitor was found in culture supernatant fluids than occurred in corresponding cell extracts of equal volume. The differences and similarities between pesticin I and some known bacteriocins are discussed. PMID:14016110

  12. Building reactive copper center(s) in human carbonic anhydrase II

    PubMed Central

    Song, He; Weitz, Andrew C.; Hendrich, Michael P.; Lewis, Edwin A.; Emerson, Joseph P.

    2014-01-01

    Re-engineering metalloproteins to generate new biologically relevant metal centers is an effective a way to test our understanding of the structural and mechanistic features that steer chemical transformations in biological systems. Here we report thermodynamic data characterizing the formation of two type-2 (T2) copper sites in carbonic anhydrase and experimental evidence showing one of these new copper centers has characteristics similar to a variety of well-characterized copper centers in synthetic models and in enzymatic systems. Human CA II is known to bind two Cu2+ ions; herein, these binding events are explored using modern isothermal titration calorimetry (ITC) techniques that have become a proven method to accurately measure metal-binding thermodynamic parameters. The two Cu2+-binding events have different affinities (Ka ∼ 5 × 1012 and 1 × 1010) and both are enthalpically driven processes. Reconstituting these Cu2+ sites under a range of conditions has allowed us to assign the Cu2+-binding event to the three-histidine, native, metal binding site. Our initial efforts to characterize these Cu2+ sites have yielded data that show distinctive (and noncoupled) EPR signals associated with each copper-binding site, and that this reconstituted enzyme can activate hydrogen peroxide to catalyze the oxidation of 2-aminophenol. PMID:23744511

  13. Structural, Spectroscopic, and Electrochemical Properties of Nonheme Fe(II)-Hydroquinonate Complexes: Synthetic Models of Hydroquinone Dioxygenases

    PubMed Central

    Baum, Amanda E.; Park, Heaweon; Wang, Denan; Lindeman, Sergey V.; Fiedler, Adam T.

    2012-01-01

    Using the tris(3,5-diphenylpyrazol-1-yl)borate (Ph2Tp) supporting ligand, a series of mono- and dinuclear ferrous complexes containing hydroquinonate (HQate) ligands have been prepared and structurally characterized with X-ray crystallography. The monoiron(II) complexes serve as faithful mimics of the substrate-bound form of hydroquinone dioxygenases (HQDOs) – a family of nonheme Fe enzymes that catalyze the oxidative cleavage of 1,4-dihydroxybenzene units. Reflecting the variety of HQDO substrates, the synthetic complexes feature both mono- and bidentate HQate ligands. The bidentate HQates cleanly provide five-coordinate, high-spin Fe(II) complexes with the general formula [Fe(Ph2Tp)(HLX)] (1X), where HLX is a HQate(1-) ligand substituted at the 2-position with a benzimidazolyl (1A), acetyl (1B and 1C), or methoxy (1D) group. In contrast, the monodentate ligand 2,6-dimethylhydroquinone (H2LF) exhibited a greater tendency to bridge between two Fe(II) centers, resulting in formation of [Fe2(Ph2Tp)2(μ-LF)(MeCN)] [2F(MeCN)]. However, addition of one equivalent of “free” pyrazole (Ph2pz) ligand provided the mononuclear complex, [Fe(Ph2Tp)(HLF)(Ph2pz)] [1F(Ph2pz)], which is stabilized by an intramolecular hydrogen bond between the HLF and Ph2pz donors. Complex 1F(Ph2pz) represents the first crystallographically-characterized example of a monoiron complex bound to an untethered HQate ligand. The geometric and electronic structures of the Fe/HQate complexes were further probed with spectroscopic (UV-vis absorption, 1H NMR) and electrochemical methods. Cyclic voltammograms of complexes in the 1X series revealed an Fe-based oxidation between 0 and −300 mV (vs. Fc+/0), in addition to irreversible oxidation(s) of the HQate ligand at higher potentials. The one-electron oxidized species (1Xox) were examined with UV-vis absorption and electron paramagnetic resonance (EPR) spectroscopies. PMID:22930005

  14. Four-coordinate nickel(II) and copper(II) complex based ONO tridentate Schiff base ligands: synthesis, molecular structure, electrochemical, linear and nonlinear properties, and computational study.

    PubMed

    Novoa, Néstor; Roisnel, Thierry; Hamon, Paul; Kahlal, Samia; Manzur, Carolina; Ngo, Hoang Minh; Ledoux-Rak, Isabelle; Saillard, Jean-Yves; Carrillo, David; Hamon, Jean-René

    2015-11-07

    We report the synthesis, characterization, crystal structures, nonlinear-optical (NLO) properties, and density functional theory (DFT) calculations of nickel(ii) and copper(ii) complex based ONO tridentate Schiff base ligands: two mononuclear compounds, [Ni(An-ONO)(NC5H5)] (5) and [Cu(An-ONO)(4-NC5H4C(CH3)3)] (6), and two heterobimetallic species, [M(Fc-ONO)(NC5H5)] (M = Ni, 7; Cu, 8), where An-ONOH2 (3) and Fc-ONOH2 (4) are the 1 : 1 condensation products of 2-aminophenol and p-anisoylacetone and ferrocenoylacetone, respectively. These compounds were characterised by microanalysis, FT-IR and X-ray crystallography in the solid state and in solution by UV-vis and (1)H and (13)C NMR spectroscopy. The crystal structures of 3-5, 7 and 8 have been determined and show for Schiff base complexes 5, 7 and 8 a four-coordinated square-planar environment for nickel and copper ions. The electrochemical behavior of all derivatives 3-8 was investigated by cyclic voltammetry in dichloromethane, and discussed on the basis of DFT-computed electronic structures of the neutral and oxidized forms of the compounds. The second-order NLO responses of 3-8 have been determined by harmonic light scattering measurements using a 10(-2) M solution of dichloromethane and working with a 1.91 μm incident wavelength, giving rather high β1.91 values of 350 and 290 × 10(-30) esu for the mononuclear species 5 and 6, respectively. The assignment and the nature of the electronic transitions observed in the UV-vis spectra were analyzed using time-dependent (TD) DFT calculations. They are dominated by LMCT, MLCT and π-π* transitions.

  15. Synthesis, crystal structure, spectral studies, and catechol oxidase activity of trigonal bipyramidal Cu(II) complexes derived from a tetradentate diamide bisbenzimidazole ligand.

    PubMed

    Gupta, M; Mathur, P; Butcher, R J

    2001-02-26

    . Palaniandavar, M.; Pandiyan, T.; Laxminarayan, M.; Manohar, H. J. Chem. Soc., Dalton Trans. 1995, 457. Sakurai, T.; Oi, H.; Nakahara, A. Inorg. Chim. Acta 1984, 92, 131). It is therefore concluded that binding of amide carbonyl oxygen destabilizes the Cu(II) state. The complex [Cu(II)(GBHA)(NO(3))](NO(3)) could be successfully reduced by the addition of dihydroxybenzenes to the corresponding [Cu(I)(GBHA)](NO(3)). (1)H NMR of the reduced complex shows slightly broadened and shifted (1)H signals. The reduction of the Cu(II) complex presumably occurs with the corresponding 2e(-) oxidation of the quinol to quinone. Such a conversion is reminiscent of the functioning of a copper-containing catechol oxidase from sweet potatoes and the met form of the enzyme tyrosinase.

  16. Final report on the safety assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol.

    PubMed

    2004-01-01

    Each of these ingredients function as hair colorants. 5-Amino-4-Chloro-o-Cresol and 5-Amino-6-Chloro-o-Cresol are identified as oxidative hair dyes, that is, they are combined with an oxidizing agent before being applied to the hair. 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, and 5-Amino-4-Chloro-o-Cresol are used in oxidative hair dyes, but it is not known if they are also used in nonoxidative (semipermanent) hair dyes. No toxicologically significant impurities are present with these two ingredients. To supplement the safety test data on these ingredients, available data on related ingredients (4-amino-2-hydroxytoluene and p-,m-, and o-aminophenol) previously found safe as used by the Cosmetic Ingredient Review (CIR) Expert Panel were summarized. 5-Amino-4-Chloro-o-Cresol and 5-Amino-6-Chloro-o-Cresol do not absorb significant ultraviolet radiation in the UVB region and none in the UVA region, although 4-Amino-m-Cresol had a symmetrical UV absorption peak at 300 nm. Percutaneous penetration of 5-Amino-4-Chloro-o-Cresol and 5-Amino-6-Chloro-o-Cresol alone was significant, but when combined with oxidative developer, skin absorption was extremely low. Both of these dyes are excreted rapidly via the urine. Repeated exposure of animal skin to 5-Amino-4-Chloro-o-Cresol and 5-Amino-6-Chloro-o-Cresol failed to produce any cumulative irritation and single exposures up to 10%were not irritating to animal skin. 5-Amino-4-Chloro-o-Cresol and 5-Amino-6-Chloro-o-Cresol combined with oxidizer were not sensitizers in guinea pig maximization tests. Ocular irritation resulted from exposure of animals to undiluted 5-Amino-4-Chloro-o-Cresol, but not to a 5%solution. Only minor irritation was observed with 5%5-Amino-6-Chloro-o-Cresol. Subchronic toxicity testing in animals using 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Amino-m-Cresol did not yield any adverse reactions. 6-Amino-m-Cresol and 4-Amino-m-Cresol were generally not mutagenic in in vitro and in

  17. Ovarian Cancer Stage II

    MedlinePlus

    ... Download Title: Ovarian Cancer Stage II Description: Three-panel drawing of stage IIA, IIB, and stage II primary peritoneal cancer; the first panel (stage IIA) shows cancer inside both ovaries that ...

  18. Factor II deficiency

    MedlinePlus

    ... if one or more of these factors are missing or are not functioning like they should. Factor II is one such coagulation factor. Factor II deficiency runs in families (inherited) and is very rare. Both parents must ...

  19. Development of an extractive spectrophotometric method for estimation of uranium in ore leach solutions using 2-ethylhexyl phosphonic acid-mono-2-ethylhexyl ester (PC88A) and tri-n-octyl phosphine oxide (TOPO) mixture as extractant and 2-(5-bromo-2-pyridylozo)-5-diethyl aminophenol (Br-PADAP) as chromophore.

    PubMed

    Biswas, Sujoy; Pathak, P N; Roy, S B

    2012-06-01

    An extractive spectrophotometric analytical method has been developed for the determination of uranium in ore leach solution. This technique is based on the selective extraction of uranium from multielement system using a synergistic mixture of 2-ethylhexyl phosphonic acid-mono-2-ethylhexyl ester (PC88A) and tri-n-octyl phosphine oxide (TOPO) in cyclohexane and color development from the organic phase aliquot using 2-(5-Bromo-2-pyridylazo)-5-diethyl aminophenol (Br-PADAP) as chromogenic reagent. The absorption maximum (λ(max)) for UO(2)(2+)-Br-PADAP complex in organic phase samples, in 64% (v/v) ethanol containing buffer solution (pH 7.8) and 1,2-cyclohexylenedinitrilotetraacetic acid (CyDTA) complexing agent, has been found to be at 576 nm (molar extinction coefficient, ɛ: 36,750 ± 240 L mol(-1)cm(-1)). Effects of various parameters like stability of complex, ethanol volume, ore matrix, interfering ions etc. on the determination of uranium have also been evaluated. Absorbance measurements as a function of time showed that colored complex is stable up to > 24h. Presence of increased amount of ethanol in colored solution suppresses the absorption of a standard UO(2)(2+)-Br-PADAP solution. Analyses of synthetic standard as well as ore leach a solution show that for 10 determination relative standard deviation (RSD) is < 2%. The accuracy of the developed method has been checked by determining uranium using standard addition method and was found to be accurate with a 98-105% recovery rate. The developed method has been applied for the analysis of a number of uranium samples generated from uranium ore leach solutions and results were compared with standard methods like inductively coupled plasma emission spectrometry (ICPAES). The determined values of uranium concentrations by these methods are within ± 2%. This method can be used to determine 2.5-250 μg mL(-1) uranium in ore leach solutions with high accuracy and precision.

  20. World War II Homefront.

    ERIC Educational Resources Information Center

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  1. FIRE II Cirrus Info

    Atmospheric Science Data Center

    2014-03-18

    ... Page:  FIRE II Main Grouping:  Cirrus Description:  First ISCCP Regional Experiment (FIRE) ... stratocumulus systems, the radiative properties of these clouds and their interactions. Data Products:  Cirrus ...

  2. START II and beyond

    SciTech Connect

    Mendelsohn, J.

    1996-10-01

    The second Strategic Arms Reduction Treaty (START II), signed by President George Bush and Russian President Boris yeltsin in January 1993, was ratified by the US Senate in January 1996 by and overwhelming vote of 87-4. The treaty, which will slash the strategic arsenals of the United States and Russia to 3,000-3,500 warheads each, is now before the two houses of the Russian Parliament (the Duma and the Federation Council) awaiting ratification amidst confusion and criticism. The Yeltsin administration supports START II and spoke in favor of Russian ratification after the Senate acted on the treaty. The Russian foreign minister and the Russian military believed that START II should be ratified as soon as possible. During the recent presidential campaign and his subsequent illness, President Yeltsin has been virtually silent on the subject of START II and nuclear force reductions. Without a push from the Yeltsin administration, the tone among Duma members, has been sharply critical of START II. Voices across the Russian political spectrum have questioned the treaty and linked it to constraints on highly capable theater missile defense (TMD) systems and the continued viability of the ABM Treaty. And urged that START II ratification be held hostage until NATO abandons its plans to expand eastward. Although the START I and START II accords have generated the momentum, opportunity and expectation-both domestic and international-for additional nuclear arms reductions, the current impasse over ratification in the Duma has cast a shadow over the future of START II and raised questions about the chances for any follow-on (START III) agreement.

  3. Mod II engine development

    NASA Technical Reports Server (NTRS)

    Karl, David W.

    1987-01-01

    The Mod II engine, a four-cylinder, automotive Stirling engine utilizing the Siemens-Rinia double-acting concept, was assembled and became operational in January 1986. This paper describes the Mod II engine, its first assembly, and the subsequent development work done on engine components up to the point that engine performance characterization testing took place. Performance data for the engine are included.

  4. Carnitine palmitoyltransferase II deficiency

    PubMed Central

    Roe, C R.; Yang, B-Z; Brunengraber, H; Roe, D S.; Wallace, M; Garritson, B K.

    2008-01-01

    Background: Carnitine palmitoyltransferase II (CPT II) deficiency is an important cause of recurrent rhabdomyolysis in children and adults. Current treatment includes dietary fat restriction, with increased carbohydrate intake and exercise restriction to avoid muscle pain and rhabdomyolysis. Methods: CPT II enzyme assay, DNA mutation analysis, quantitative analysis of acylcarnitines in blood and cultured fibroblasts, urinary organic acids, the standardized 36-item Short-Form Health Status survey (SF-36) version 2, and bioelectric impedance for body fat composition. Diet treatment with triheptanoin at 30% to 35% of total daily caloric intake was used for all patients. Results: Seven patients with CPT II deficiency were studied from 7 to 61 months on the triheptanoin (anaplerotic) diet. Five had previous episodes of rhabdomyolysis requiring hospitalizations and muscle pain on exertion prior to the diet (two younger patients had not had rhabdomyolysis). While on the diet, only two patients experienced mild muscle pain with exercise. During short periods of noncompliance, two patients experienced rhabdomyolysis with exercise. None experienced rhabdomyolysis or hospitalizations while on the diet. All patients returned to normal physical activities including strenuous sports. Exercise restriction was eliminated. Previously abnormal SF-36 physical composite scores returned to normal levels that persisted for the duration of the therapy in all five symptomatic patients. Conclusions: The triheptanoin diet seems to be an effective therapy for adult-onset carnitine palmitoyltransferase II deficiency. GLOSSARY ALT = alanine aminotransferase; AST = aspartate aminotransferase; ATP = adenosine triphosphate; BHP = β-hydroxypentanoate; BKP = β-ketopentanoate; BKP-CoA = β-ketopentanoyl–coenzyme A; BUN = blood urea nitrogen; CAC = citric acid cycle; CoA = coenzyme A; CPK = creatine phosphokinase; CPT II = carnitine palmitoyltransferase II; LDL = low-density lipoprotein; MCT

  5. About APPLE II Operation

    SciTech Connect

    Schmidt, T.; Zimoch, D.

    2007-01-19

    The operation of an APPLE II based undulator beamline with all its polarization states (linear horizontal and vertical, circular and elliptical, and continous variation of the linear vector) requires an effective description allowing an automated calculation of gap and shift parameter as function of energy and operation mode. The extension of the linear polarization range from 0 to 180 deg. requires 4 shiftable magnet arrrays, permitting use of the APU (adjustable phase undulator) concept. Studies for a pure fixed gap APPLE II for the SLS revealed surprising symmetries between circular and linear polarization modes allowing for simplified operation. A semi-analytical model covering all types of APPLE II and its implementation will be presented.

  6. Mod II engine performance

    NASA Technical Reports Server (NTRS)

    Richey, Albert E.; Huang, Shyan-Cherng

    1987-01-01

    The testing of a prototype of an automotive Stirling engine, the Mod II, is discussed. The Mod II is a one-piece cast block with a V-4 single-crankshaft configuration and an annular regenerator/cooler design. The initial testing of Mod II concentrated on the basic engine, with auxiliaries driven by power sources external to the engine. The performance of the engine was tested at 720 C set temperature and 820 C tube temperature. At 720 C, it is observed that the power deficiency is speed dependent and linear, with a weak pressure dependency, and at 820 C, the power deficiency is speed and pressure dependent. The effects of buoyancy and nozzle spray pattern on the heater temperature spread are investigated. The characterization of the oil pump and the operating cycle and temperature spread tests are proposed for further evaluation of the engine.

  7. SAGE II Ozone Analysis

    NASA Technical Reports Server (NTRS)

    Cunnold, Derek; Wang, Ray

    2002-01-01

    Publications from 1999-2002 describing research funded by the SAGE II contract to Dr. Cunnold and Dr. Wang are listed below. Our most recent accomplishments include a detailed analysis of the quality of SAGE II, v6.1, ozone measurements below 20 km altitude (Wang et al., 2002 and Kar et al., 2002) and an analysis of the consistency between SAGE upper stratospheric ozone trends and model predictions with emphasis on hemispheric asymmetry (Li et al., 2001). Abstracts of the 11 papers are attached.

  8. Instant Insanity II

    ERIC Educational Resources Information Center

    Richmond, Tom; Young, Aaron

    2013-01-01

    "Instant Insanity II" is a sliding mechanical puzzle whose solution requires the special alignment of 16 colored tiles. We count the number of solutions of the puzzle's classic challenge and show that the more difficult ultimate challenge has, up to row permutation, exactly two solutions, and further show that no…

  9. Dissecting Diversity Part II

    ERIC Educational Resources Information Center

    Matthews, Frank

    2005-01-01

    This article presents "Dissecting Diversity, Part II," the conclusion of a wide-ranging two-part roundtable discussion on diversity in higher education. The participants were as follows: Lezli Baskerville, J.D., President and CEO of the National Association for Equal Opportunity (NAFEO); Dr. Gerald E. Gipp, Executive Director of the…

  10. Listen & Learn II.

    ERIC Educational Resources Information Center

    Community Building Resources, Spruce Grove (Alberta).

    Six community builders in Edmonton, Alberta, planned, developed, and implemented Listen and Learn II, a reflective research project in asset-based community building, over a 6-month period in 1998. They met regularly over 2 months to plan the research and design a method that was open to participation at any stage, encouraged exchange of…

  11. A la Mode II.

    ERIC Educational Resources Information Center

    Stowe, Richard A.

    This paper describes two modes of educational decision-making: Mode I, in which the instructor makes such decisions as what to teach, to whom, when, in what order, at what pace, and at what complexity level; and Mode II, in which the learner makes the decisions. While Mode I comprises most of what is regarded as formal education, the learner in…

  12. Periodontics II: Course Proposal.

    ERIC Educational Resources Information Center

    Dordick, Bruce

    A proposal is presented for Periodontics II, a course offered at the Community College of Philadelphia to give the dental hygiene/assisting student an understanding of the disease states of the periodontium and their treatment. A standardized course proposal cover form is given, followed by a statement of purpose for the course, a list of major…

  13. Class II Microcins

    NASA Astrophysics Data System (ADS)

    Vassiliadis, Gaëlle; Destoumieux-Garzón, Delphine; Peduzzi, Jean

    Class II microcins are 4.9- to 8.9-kDa polypeptides produced by and active against enterobacteria. They are classified into two subfamilies according to their structure and their gene cluster arrangement. While class IIa microcins undergo no posttranslational modification, class IIb microcins show a conserved C-terminal sequence that carries a salmochelin-like siderophore motif as a posttranslational modification. Aside from this C-terminal end, which is the signature of class IIb microcins, some sequence similarities can be observed within and between class II subclasses, suggesting the existence of common ancestors. Their mechanisms of action are still under investigation, but several class II microcins use inner membrane proteins as cellular targets, and some of them are membrane-active. Like group B colicins, many, if not all, class II microcins are TonB- and energy-dependent and use catecholate siderophore receptors for recognition/­translocation across the outer membrane. In that context, class IIb microcins are considered to have developed molecular mimicry to increase their affinity for their outer membrane receptors through their salmochelin-like posttranslational modification.

  14. Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence.

    PubMed

    Han, Ying-Hao; Kim, Hyun-Sun; Kim, Jin-Man; Kim, Sang-Keun; Yu, Dae-Yeul; Moon, Eun-Yi

    2005-08-29

    Reactive oxygen species (ROS) were generated in all oxygen-utilizing organisms. Peroxiredoxin II (Prx II) as one of antioxidant enzymes may play a protective role against the oxidative damage caused by ROS. In order to define the role of Prx II in organismal aging, we evaluated cellular senescence in Prx II(-/-) mouse embryonic fibroblast (MEF). As compared to wild type MEF, cellular senescence was accelerated in Prx II(-/-) MEF. Senescence-associated (SA)-beta-galactosidase (Gal)-positive cell formation was about 30% higher in Prx II(-/-) MEF. N-Acetyl-l-cysteine (NAC) treatment attenuated SA-beta-Gal-positive cell formation. Prx II(-/-) MEF exhibited the higher G2/M (41%) and lower S (1.6%) phase cells as compared to 24% and 7.3% [corrected] in wild type MEF, respectively. A high increase in the p16 and a slight increase in the p21 and p53 levels were detected in PrxII(-/-) MEF cells. The cellular senescence of Prx II(-/-) MEF was correlated with the organismal aging of Prx II(-/-) mouse skin. While extracellular signal-regulated kinase (ERK) and p38 activation was detected in Prx II(-/-) MEF, ERK and c-Jun N-terminal kinase (JNK) activation was detected in Prx II(-/-) skin. These results suggest that Prx II may function as an enzymatic antioxidant to prevent cellular senescence and skin aging.

  15. Visual discrimination of dihydroxybenzene isomers based on a nitrogen-doped graphene quantum dot-silver nanoparticle hybrid

    NASA Astrophysics Data System (ADS)

    Shi, Bingfang; Su, Yubin; Zhao, Jingjin; Liu, Rongjun; Zhao, Yan; Zhao, Shulin

    2015-10-01

    A room temperature reducing agent-free strategy for the synthesis of a nitrogen-doped graphene quantum dot-silver nanoparticle (N-GQD/AgNP) hybrid was presented. In this strategy, N-GQDs were used as a reducing agent and stabilizer for the formation of the N-GQD/AgNP hybrid, and the formation of the N-GQD/AgNP hybrid may result from the extraordinary reduction properties of N-GQDs, which are attributed to the nature of the surface oxygen-containing functional groups. The N-GQD/AgNP hybrid exhibits good dispersity and outstanding catalytic ability toward the oxidation of catechol (CC) and hydroquinone (HQ) by Ag+. In the presence of the N-GQD/AgNP hybrid, the reduction of Ag+ by CC and HQ was improved. CC enhanced the absorbance of the N-GQD/AgNP-Ag+ system the most, and HQ followed, while resorcinol (RC) had only a little effect on the absorption intensity of the system. Thus, a sensitive and selective colorimetric sensing method based on the N-GQD/AgNP-Ag+ system was developed for the discrimination of CC, HQ and RC. A good linear relationship was obtained from 0.1 to 15.0 μM for CC and from 0.3 to 20.0 μM for HQ. The detection limits of CC and HQ were 0.03 and 0.1 μM, respectively. In addition, the proposed method also shows a high selectivity for the detection of CC and HQ, and appreciable changes in color of the N-GQD/AgNP-Ag+ system toward CC, RC and HQ were observed.A room temperature reducing agent-free strategy for the synthesis of a nitrogen-doped graphene quantum dot-silver nanoparticle (N-GQD/AgNP) hybrid was presented. In this strategy, N-GQDs were used as a reducing agent and stabilizer for the formation of the N-GQD/AgNP hybrid, and the formation of the N-GQD/AgNP hybrid may result from the extraordinary reduction properties of N-GQDs, which are attributed to the nature of the surface oxygen-containing functional groups. The N-GQD/AgNP hybrid exhibits good dispersity and outstanding catalytic ability toward the oxidation of catechol (CC) and hydroquinone (HQ) by Ag+. In the presence of the N-GQD/AgNP hybrid, the reduction of Ag+ by CC and HQ was improved. CC enhanced the absorbance of the N-GQD/AgNP-Ag+ system the most, and HQ followed, while resorcinol (RC) had only a little effect on the absorption intensity of the system. Thus, a sensitive and selective colorimetric sensing method based on the N-GQD/AgNP-Ag+ system was developed for the discrimination of CC, HQ and RC. A good linear relationship was obtained from 0.1 to 15.0 μM for CC and from 0.3 to 20.0 μM for HQ. The detection limits of CC and HQ were 0.03 and 0.1 μM, respectively. In addition, the proposed method also shows a high selectivity for the detection of CC and HQ, and appreciable changes in color of the N-GQD/AgNP-Ag+ system toward CC, RC and HQ were observed. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr04659a

  16. Role of Bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-Responsive Repressor

    SciTech Connect

    Kandegedara, A.; Thiyagarajan, S; Kondapalli, K; Stemmler, T; Rosen, B

    2009-01-01

    The Staphylococcus aureus plasmid pI258 cadCA operon encodes a P-type ATPase, CadA, that confers resistance to Cd(II)/Pb(II)/Zn(II). Expression is regulated by CadC, a homodimeric repressor that dissociates from the cad operator/promoter upon binding of Cd(II), Pb(II), or Zn(II). CadC is a member of the ArsR/SmtB family of metalloregulatory proteins. The crystal structure of CadC shows two types of metal binding sites, termed Site 1 and Site 2, and the homodimer has two of each. Site 1 is the physiological inducer binding site. The two Site 2 metal binding sites are formed at the dimerization interface. Site 2 is not regulatory in CadC but is regulatory in the homologue SmtB. Here the role of each site was investigated by mutagenesis. Both sites bind either Cd(II) or Zn(II). However, Site 1 has higher affinity for Cd(II) over Zn(II), and Site 2 prefers Zn(II) over Cd(II). Site 2 is not required for either derepression or dimerization. The crystal structure of the wild type with bound Zn(II) and of a mutant lacking Site 2 was compared with the SmtB structure with and without bound Zn(II). We propose that an arginine residue allows for Zn(II) regulation in SmtB and, conversely, a glycine results in a lack of regulation by Zn(II) in CadC. We propose that a glycine residue was ancestral whether the repressor binds Zn(II) at a Site 2 like CadC or has no Site 2 like the paralogous ArsR and implies that acquisition of regulatory ability in SmtB was a more recent evolutionary event.

  17. Multiple endocrine neoplasia (MEN) II

    MedlinePlus

    Sipple syndrome; MEN II; Pheochromocytoma - MEN II; Thyroid cancer - pheochromocytoma; Parathyroid cancer - pheochromocytoma ... often not cancerous (benign). Medullary carcinoma of the thyroid is ... fatal cancer, but early diagnosis and surgery can often lead ...

  18. FIRE II - Cirrus Data Sets

    Atmospheric Science Data Center

    2013-07-26

    FIRE II - Cirrus Data Sets First ISCCP Regional Experiment (FIRE) II Cirrus was conducted in southeastern Kansas. It was designed to improve the ... stratocumulus systems, the radiative properties of these clouds and their interactions. Relevant Documents:  FIRE ...

  19. RADTRAN II user guide

    SciTech Connect

    Madsen, M M; Wilmot, E L; Taylor, J M

    1983-02-01

    RADTRAN II is a flexible analytical tool for calculating both the incident-free and accident impacts of transporting radioactive materials. The consequences from incident-free shipments are apportioned among eight population subgroups and can be calculated for several transport modes. The radiological accident risk (probability times consequence summed over all postulated accidents) is calculated in terms of early fatalities, early morbidities, latent cancer fatalities, genetic effects, and economic impacts. Groundshine, inhalation, direct exposure, resuspension, and cloudshine dose pathways are modeled to calculate the radiological health risks from accidents. Economic impacts are evaluated based on costs for emergency response, cleanup, evacuation, income loss, and land use. RADTRAN II can be applied to specific scenario evaluations (individual transport modes or specified combinations), to compare alternative modes or to evaluate generic radioactive material shipments. Unit-risk factors can easily be evaluated to aid in performing generic analyses when several options must be compared with the amount of travel as the only variable.

  20. Results from SAGE II

    SciTech Connect

    Nico, J.S.

    1994-10-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66{sub -13}{sup +18} (stat) {sub -7}{sup +5} (sys) SNU. Combined with the SAGE I result of 73{sub -16}{sup +18} (stat) {sub -7}{sup 5} (sys) SNU, the capture rate is 69{sub -11}{sup +11} (stat) {sub -7}{sup +5} (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models.

  1. Ribosomal Database Project II

    DOE Data Explorer

    The Ribosomal Database Project (RDP) provides ribosome related data and services to the scientific community, including online data analysis and aligned and annotated Bacterial small-subunit 16S rRNA sequences. As of March 2008, RDP Release 10 is available and currently (August 2009) contains 1,074,075 aligned 16S rRNA sequences. Data that can be downloaded include zipped GenBank and FASTA alignment files, a histogram (in Excel) of the number of RDP sequences spanning each base position, data in the Functional Gene Pipeline Repository, and various user submitted data. The RDP-II website also provides numerous analysis tools.[From the RDP-II home page at http://rdp.cme.msu.edu/index.jsp

  2. Operation Everest II

    PubMed Central

    2010-01-01

    Abstract Wagner, Peter D. Operation Everest II. High Alt. Med. Biol. 11:111–119, 2010.—In October 1985, 25 years ago, 8 subjects and 27 investigators met at the United States Army Research Institute for Environmental Medicine (USARIEM) altitude chambers in Natick, Massachusetts, to study human responses to a simulated 40-day ascent of Mt. Everest, termed Operation Everest II (OE II). Led by Charlie Houston, John Sutton, and Allen Cymerman, these investigators conducted a large number of investigations across several organ systems as the subjects were gradually decompressed over 40 days to the Everest summit equivalent. There the subjects reached a \\documentclass{aastex}\\usepackage{amsbsy}\\usepackage{amsfonts}\\usepackage{amssymb}\\usepackage{bm}\\usepackage{mathrsfs}\\usepackage{pifont}\\usepackage{stmaryrd}\\usepackage{textcomp}\\usepackage{portland,xspace}\\usepackage{amsmath,amsxtra}\\pagestyle{empty}\\DeclareMathSizes{10}{9}{7}{6} \\begin{document} \\begin{align*} \\dot{\\rm V}{\\sc O}_2{\\rm max} \\end{align*} \\end{document} of 15.3 mL/kg/min (28% of initial sea-level values) at 100 W and arterial Po2 and Pco2 of ∼28 and ∼10 mm Hg, respectively. Cardiac function resisted hypoxia, but the lungs could not: ventilation–perfusion inequality and O2 diffusion limitation reduced arterial oxygenation considerably. Pulmonary vascular resistance was increased, was not reversible after short-term hyperoxia, but was reduced during exercise. Skeletal muscle atrophy occurred, but muscle structure and function were otherwise remarkably unaffected. Neurological deficits (cognition and memory) persisted after return to sea level, more so in those with high hypoxic ventilatory responsiveness, with motor function essentially spared. Nine percent body weight loss (despite an unrestricted diet) was mainly (67%) from muscle and exceeded the 2% predicted from energy intake–expenditure balance. Some immunological and lipid metabolic changes occurred, of uncertain

  3. AWIPS II Extended - Data Delivery

    NASA Astrophysics Data System (ADS)

    Henry, R.; Schotz, S.; Calkins, J.; Gockel, B.; Ortiz, C.; Peter, R.

    2012-12-01

    AWIPS II Technology Infusion is a multiphase program. The first phase is the migration of the Weather Forecast Offices (WFOs) and River Forecast Centers (RFCs) AWIPS I capabilities into a Service Oriented Architecture (SOA), referred to as AWIPS II. AWIPS II is currently being deployed to Operational Test and Evaluation (OTE) and other select deployment sites. The subsequent phases of AWIPS Technology Infusion, known as AWIPS II Extended, include several projects that will improve technological capabilities of AWIPS II in order to enhance the NWS enterprise and improve services to partners. This paper summarizes AWIPS II Extended - Data Delivery project and reports on its status. Data Delivery enables AWIPS II users to discover, subscribe and access web-enabled data provider systems including the capability to subset datasets by space, time and parameter.

  4. Delta II Mars Pathfinder

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Final preparations for lift off of the DELTA II Mars Pathfinder Rocket are shown. Activities include loading the liquid oxygen, completing the construction of the Rover, and placing the Rover into the Lander. After the countdown, important visual events include the launch of the Delta Rocket, burnout and separation of the three Solid Rocket Boosters, and the main engine cutoff. The cutoff of the main engine marks the beginning of the second stage engine. After the completion of the second stage, the third stage engine ignites and then cuts off. Once the third stage engine cuts off spacecraft separation occurs.

  5. Run II luminosity progress

    SciTech Connect

    Gollwitzer, K.; /Fermilab

    2007-06-01

    The Fermilab Tevatron Collider Run II program continues at the energy and luminosity frontier of high energy particle physics. To the collider experiments CDF and D0, over 3 fb{sup -1} of integrated luminosity has been delivered to each. Upgrades and improvements in the Antiproton Source of the production and collection of antiprotons have led to increased number of particles stored in the Recycler. Electron cooling and associated improvements have help make a brighter antiproton beam at collisions. Tevatron improvements to handle the increased number of particles and the beam lifetimes have resulted in an increase in luminosity.

  6. SAGE II aerosol data validation - Comparative studies of SAGE II and SAM II data sets

    NASA Technical Reports Server (NTRS)

    Yue, G. K.; Mccormick, M. P.; Chu, W. P.; Wang, P. H.; Osborn, M. T.

    1989-01-01

    Data from the Stratospheric Aerosol and Gas Experiment (SAGE II) satellite are compared with data from the Stratospheric Aerosol Measurement (SAM II) satellite. Both experiments produce aerosol extinction profiles by measuring the attenuation of solar radiation during each sunrise and sunset observed by the satelltie. The SAGE II obtains profiles at 1.02 microns and three smaller wavelengths, whereas the SAM II measures at only one radiometric channel at 1.0 microns. It is found that the differences between the two sets of data are generally within the error bars associated with each measurement. In addition, the sunrise and sunset data from SAGE II are analyzed.

  7. Determination of aminocresol isomers by high-speed liquid chromatography.

    PubMed

    Sakurai, H; Kito, M

    Aminocresol isomers (4-hydroxy-m-toluidine [II], 3-hydroxy-p-toluidine [II], 2-hydroxy-p-toluidine [III]) and p-aminophenol have been separated and determined by a high-speed liquid Chromatographie method. Since this method is applicable in aqueous media, it was used to investigate the suitability of a haemin-cysteine system as a model for the cytochrome P-450 mono-oxygenase system, by determination of the [I], [II], [III] and p-aminophenol formed.

  8. The Belle II Detector

    NASA Astrophysics Data System (ADS)

    Piilonen, Leo; Belle Collaboration, II

    2017-01-01

    The Belle II detector is now under construction at the KEK laboratory in Japan. This project represents a substantial upgrade of the Belle detector (and the KEKB accelerator). The Belle II experiment will record 50 ab-1 of data, a factor of 50 more than that recorded by Belle. This large data set, combined with the low backgrounds and high trigger efficiencies characteristic of an e+e- experiment, should provide unprecedented sensitivity to new physics signatures in B and D meson decays, and in τ lepton decays. The detector comprises many forefront subsystems. The vertex detector consists of two inner layers of silicon DEPFET pixels and four outer layers of double-sided silicon strips. These layers surround a beryllium beam pipe having a radius of only 10 mm. Outside of the vertex detector is a large-radius, small-cell drift chamber, an ``imaging time-of-propagation'' detector based on Cerenkov radiation for particle identification, and scintillating fibers and resistive plate chambers used to identify muons. The detector will begin commissioning in 2017.

  9. Effect of Cu(II), Cd(II) and Zn(II) on Pb(II) biosorption by algae Gelidium-derived materials.

    PubMed

    Vilar, Vítor J P; Botelho, Cidália M S; Boaventura, Rui A R

    2008-06-15

    Biosorption of Pb(II), Cu(II), Cd(II) and Zn(II) from binary metal solutions onto the algae Gelidium sesquipedale, an algal industrial waste and a waste-based composite material was investigated at pH 5.3, in a batch system. Binary Pb(II)/Cu(II), Pb(II)/Cd(II) and Pb(II)/Zn(II) solutions have been tested. For the same equilibrium concentrations of both metal ions (1 mmol l(-1)), approximately 66, 85 and 86% of the total uptake capacity of the biosorbents is taken by lead ions in the systems Pb(II)/Cu(II), Pb(II)/Cd(II) and Pb(II)/Zn(II), respectively. Two-metal results were fitted to a discrete and a continuous model, showing the inhibition of the primary metal biosorption by the co-cation. The model parameters suggest that Cd(II) and Zn(II) have the same decreasing effect on the Pb(II) uptake capacity. The uptake of Pb(II) was highly sensitive to the presence of Cu(II). From the discrete model it was possible to obtain the Langmuir affinity constant for Pb(II) biosorption. The presence of the co-cations decreases the apparent affinity of Pb(II). The experimental results were successfully fitted by the continuous model, at different pH values, for each biosorbent. The following sequence for the equilibrium affinity constants was found: Pb>Cu>Cd approximately Zn.

  10. II Zwicky 23 and Family

    NASA Astrophysics Data System (ADS)

    Wehner, E. H.; Gallagher, J. S.; Rudie, G. C.; Cigan, P. J.

    II Zwicky 23 (UGC 3179) is a luminous (MB ~ -21) nearby compact narrow emission line st arburst galaxy with blue optical colors and strong emission lines. We present a photometric and morphological study of II Zw 23 and its interacting companions using data obtained with the WIYN 3.5-m telescope in Kitt Peak, Arizona. II Zwicky 23 has a highly disturbed outer structure with long trails of debris that may be feeding tidal dwarfs.

  11. Belle II Software

    NASA Astrophysics Data System (ADS)

    Kuhr, T.; Ritter, M.; Belle Software Group, II

    2016-10-01

    Belle II is a next generation B factory experiment that will collect 50 times more data than its predecessor, Belle. The higher luminosity at the SuperKEKB accelerator leads to higher background levels and requires a major upgrade of the detector. As a consequence, the simulation, reconstruction, and analysis software must also be upgraded substantially. Most of the software has been redesigned from scratch, taking into account the experience from Belle and other experiments and utilizing new technologies. The large amount of experimental and simulated data requires a high level of reliability and reproducibility, even in parallel environments. Several technologies, tools, and organizational measures are employed to evaluate and monitor the performance of the software during development.

  12. He II-Emitting Galaxies

    NASA Astrophysics Data System (ADS)

    Heap, Sara R.

    2014-01-01

    A small fraction of star-forming galaxies at redshift, 3, show He II at 1640 A as a narrow emission line (Cassata et al. 2012), but the source of this emission is not understood. Does the He II emission arise in the stars or in the surrounding nebula? To answer this question, we use I Zw 18, a well studied blue compact dwarf galaxy showing narrow He II line emission as a test case. We consider if/how He II narrow emission lines could originate in the nearby nebulosity, or in the winds of hot, massive stars, both those on the main sequence and post-MS evolutionary phases.

  13. Mode II fatigue crack propagation.

    NASA Technical Reports Server (NTRS)

    Roberts, R.; Kibler, J. J.

    1971-01-01

    Fatigue crack propagation rates were obtained for 2024-T3 bare aluminum plates subjected to in-plane, mode I, extensional loads and transverse, mode II, bending loads. These results were compared to the results of Iida and Kobayashi for in-plane mode I-mode II extensional loads. The engineering significance of mode I-mode II fatigue crack growth is considered in view of the present results. A fatigue crack growth equation for handling mode I-mode II fatigue crack growth rates from existing mode I data is also discussed.

  14. Phase II Final Report

    SciTech Connect

    Schuknecht, Nate; White, David; Hoste, Graeme

    2014-09-11

    The SkyTrough DSP will advance the state-of-the-art in parabolic troughs for utility applications, with a larger aperture, higher operating temperature, and lower cost. The goal of this project was to develop a parabolic trough collector that enables solar electricity generation in the 2020 marketplace for a 216MWe nameplate baseload power plant. This plant requires an LCOE of 9¢/kWhe, given a capacity factor of 75%, a fossil fuel limit of 15%, a fossil fuel cost of $6.75/MMBtu, $25.00/kWht thermal storage cost, and a domestic installation corresponding to Daggett, CA. The result of our optimization was a trough design of larger aperture and operating temperature than has been fielded in large, utility scale parabolic trough applications: 7.6m width x 150m SCA length (1,118m2 aperture), with four 90mm diameter × 4.7m receivers per mirror module and an operating temperature of 500°C. The results from physical modeling in the System Advisory Model indicate that, for a capacity factor of 75%: The LCOE will be 8.87¢/kWhe. SkyFuel examined the design of almost every parabolic trough component from a perspective of load and performance at aperture areas from 500 to 2,900m2. Aperture-dependent design was combined with fixed quotations for similar parts from the commercialized SkyTrough product, and established an installed cost of $130/m2 in 2020. This project was conducted in two phases. Phase I was a preliminary design, culminating in an optimum trough size and further improvement of an advanced polymeric reflective material. This phase was completed in October of 2011. Phase II has been the detailed engineering design and component testing, which culminated in the fabrication and testing of a single mirror module. Phase II is complete, and this document presents a summary of the comprehensive work.

  15. Solar Type II Radio Bursts and IP Type II Events

    NASA Technical Reports Server (NTRS)

    Cane, H. V.; Erickson, W. C.

    2005-01-01

    We have examined radio data from the WAVES experiment on the Wind spacecraft in conjunction with ground-based data in order to investigate the relationship between the shocks responsible for metric type II radio bursts and the shocks in front of coronal mass ejections (CMEs). The bow shocks of fast, large CMEs are strong interplanetary (IP) shocks, and the associated radio emissions often consist of single broad bands starting below approx. 4 MHz; such emissions were previously called IP type II events. In contrast, metric type II bursts are usually narrowbanded and display two harmonically related bands. In addition to displaying complete dynamic spectra for a number of events, we also analyze the 135 WAVES 1 - 14 MHz slow-drift time periods in 2001-2003. We find that most of the periods contain multiple phenomena, which we divide into three groups: metric type II extensions, IP type II events, and blobs and bands. About half of the WAVES listings include probable extensions of metric type II radio bursts, but in more than half of these events, there were also other slow-drift features. In the 3 yr study period, there were 31 IP type II events; these were associated with the very fastest CMEs. The most common form of activity in the WAVES events, blobs and bands in the frequency range between 1 and 8 MHz, fall below an envelope consistent with the early signatures of an IP type II event. However, most of this activity lasts only a few tens of minutes, whereas IP type II events last for many hours. In this study we find many examples in the radio data of two shock-like phenomena with different characteristics that occur simultaneously in the metric and decametric/hectometric bands, and no clear example of a metric type II burst that extends continuously down in frequency to become an IP type II event. The simplest interpretation is that metric type II bursts, unlike IP type II events, are not caused by shocks driven in front of CMEs.

  16. Technology II: Implementation Planning Guide.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Office of the Chancellor.

    The California Community Colleges (CCC) are facing a number of challenges, including the explosive use of the Internet, the digital divide, the need for integrating technology into teaching and learning, the impact of Tidal Wave II, and the need to ensure that technology is accessible to persons with disabilities. The CCCs' Technology II Strategic…

  17. PARIS II: DESIGNING GREENER SOLVENTS

    EPA Science Inventory

    PARIS II (the program for assisting the replacement of industrial solvents, version II), developed at the USEPA, is a unique software tool that can be used for customizing the design of replacement solvents and for the formulation of new solvents. This program helps users avoid ...

  18. National Synchrotron Light Source II

    ScienceCinema

    Steve Dierker

    2016-07-12

    The National Synchrotron Light Source II (NSLS-II) at the U.S. Department of Energy's Brookhaven National Laboratory is a proposed new state-of-the-art medium energy storage ring designed to deliver world-leading brightness and flux with top-off operation

  19. Annex II technical documentation assessed.

    PubMed

    van Drongelen, A W; Roszek, B; van Tienhoven, E A E; Geertsma, R E; Boumans, R T; Kraus, J J A M

    2005-12-01

    Annex II of the Medical Device Directive (MDD) is used frequently by manufacturers to obtain CE-marking. This procedure relies on a full quality assurance system and does not require an assessment of the individual medical device by a Notified Body. An investigation into the availability and the quality of technical documentation for Annex II devices revealed severe shortcomings, which are reported here.

  20. National Synchrotron Light Source II

    SciTech Connect

    Steve Dierker

    2008-03-12

    The National Synchrotron Light Source II (NSLS-II) at the U.S. Department of Energy's Brookhaven National Laboratory is a proposed new state-of-the-art medium energy storage ring designed to deliver world-leading brightness and flux with top-off operation

  1. Crystal Structure of Rat Carnitine Palmitoyltransferase II (CPT-II)

    SciTech Connect

    Hsiao,Y.; Jogl, G.; Esser, V.; Tong, L.

    2006-01-01

    Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the {beta}-oxidation of long-chain fatty acids in mitochondria. We report here the crystal structure of rat CPT-II at 1.9 Angstroms resolution. The overall structure shares strong similarity to those of short- and medium-chain carnitine acyltransferases, although detailed structural differences in the active site region have a significant impact on the substrate selectivity of CPT-II. Three aliphatic chains, possibly from a detergent that is used for the crystallization, were found in the structure. Two of them are located in the carnitine and CoA binding sites, respectively. The third aliphatic chain may mimic the long-chain acyl group in the substrate of CPT-II. The binding site for this aliphatic chain does not exist in the short- and medium-chain carnitine acyltransferases, due to conformational differences among the enzymes. A unique insert in CPT-II is positioned on the surface of the enzyme, with a highly hydrophobic surface. It is likely that this surface patch mediates the association of CPT-II with the inner membrane of the mitochondria.

  2. Rhizobium etli asparaginase II

    PubMed Central

    Huerta-Saquero, Alejandro; Evangelista-Martínez, Zahaed; Moreno-Enriquez, Angélica; Perez-Rueda, Ernesto

    2013-01-01

    Bacterial l-asparaginase has been a universal component of therapies for childhood acute lymphoblastic leukemia since the 1970s. Two principal enzymes derived from Escherichia coli and Erwinia chrysanthemi are the only options clinically approved to date. We recently reported a study of recombinant l-asparaginase (AnsA) from Rhizobium etli and described an increasing type of AnsA family members. Sequence analysis revealed four conserved motifs with notable differences with respect to the conserved regions of amino acid sequences of type I and type II l-asparaginases, particularly in comparison with therapeutic enzymes from E. coli and E. chrysanthemi. These differences suggested a distinct immunological specificity. Here, we report an in silico analysis that revealed immunogenic determinants of AnsA. Also, we used an extensive approach to compare the crystal structures of E. coli and E. chrysantemi asparaginases with a computational model of AnsA and identified immunogenic epitopes. A three-dimensional model of AsnA revealed, as expected based on sequence dissimilarities, completely different folding and different immunogenic epitopes. This approach could be very useful in transcending the problem of immunogenicity in two major ways: by chemical modifications of epitopes to reduce drug immunogenicity, and by site-directed mutagenesis of amino acid residues to diminish immunogenicity without reduction of enzymatic activity. PMID:22895060

  3. Angiotensin II receptor heterogeneity

    SciTech Connect

    Herblin, W.F.; Chiu, A.T.; McCall, D.E.; Ardecky, R.J.; Carini, D.J.; Duncia, J.V.; Pease, L.J.; Wong, P.C.; Wexler, R.R.; Johnson, A.L. )

    1991-04-01

    The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of the authors earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes. Autoradiographic studies demonstrated that all of the labeling of the rat adrenal was blocked by unlabeled AII or saralasin, but not by DuP 753. The predominant receptor in the rat adrenal cortex (80%) is sensitive to dithiothreitol (DTT) and DuP 753, and is designated AII-1. The residual sites in the adrenal cortex and almost all of the sites in the rat adrenal medulla are insensitive to both DTT and DuP 753, but were blocked by EXP655. These sites have been confirmed by ligand binding studies and are designated AII-2. The rabbit adrenal cortex is unique in yielding a nonuniform distribution of AII-2 sites around the outer layer of glomerulosa cells. In the rabbit kidney, the sites on the glomeruli are AII-1, but the sites on the kidney capsule are AII-2. Angiotensin III appears to have a higher affinity for AII-2 sites since it inhibits the binding to the rabbit kidney capsule but not the glomeruli. Elucidation of the distribution and function of these diverse sites should permit the development of more selective and specific therapeutic strategies.

  4. Mycotoxins revisited: Part II.

    PubMed

    Berger, Kyan J; Guss, David A

    2005-02-01

    Mushrooms are ubiquitous in nature. They are an important source of nutrition, however, certain varieties contain chemicals that can be highly toxic to humans. Industrially cultivated mushrooms are historically very safe, whereas foraging for mushrooms or accidental ingestion of mushrooms in the environment can result in serious illness and death. The emergency department is the most common site of presentation for patients suffering from acute mushroom poisoning. Although recognition can be facilitated by identification of a characteristic toxidrome, the presenting manifestations can be variable and have considerable overlap with more common and generally benign clinical syndromes. The goal of this two-part article is to review the knowledge base on this subject and provide information that will assist the clinician in the early consideration, diagnosis and treatment of mushroom poisoning. Part I reviewed the epidemiology and demographics of mushroom poisoning, the physical characteristics of the most toxic varieties, the classification of the toxic species, and presented an overview of the cyclopeptide-containing mushroom class. Part II is focused on the presentation of the other classes of toxic mushrooms along with an up-to-date review of the most recently identified poisonous varieties.

  5. Options Study - Phase II

    SciTech Connect

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  6. Biosatellite II mission.

    PubMed

    Reynolds, O E

    1969-01-01

    Biosatellite B was launched from Cape Kennedy, Florida, on a two-stage DELTA launch vehicle at 6:04 p.m. on 7 September, 1967. Approximately nine minutes later the 435 kg spacecraft biological laboratory was placed into a satisfactory 315 km near-circular earth orbit, successfully separated from the launch vehicle's second stage and was designated Biosatellite II. The scientific payload consisting of thirteen selected general biology and radiation experiments were subjected to planned, carefully controlled environmental conditions during 45 hours of earth-orbital flight. The decision was made to abbreviate the scheduled 3-day mission by approximately one day because of a threatening tropical storm in the recovery area, and a problem of communication with the spacecraft from the tracking stations. Highest priority was placed on recovery which was essential to obtain the scientific results on all the experiments. The operational phase of the mission came to a successful conclusion with the deorbit of the recovery capsule, deployment of the parachute system and air recovery by the United States Air Force. The 127 kg recovery capsule was returned to biology laboratories at Hickam Air Force Base, Hawaii, for disassembly and immediate inspection and analysis of the biological materials by the experimenters. It was evident immediately that the quality of the biology was excellent and this fact gave promise of a high return of scientific data. The environmental conditions provided to the experimental material in the spacecraft, provisions for experimental controls, and operational considerations are presented as they relate to interpretation of the experimental results.

  7. Retrovirus Epidemiology Donor Study-II (REDS-II)

    ClinicalTrials.gov

    2016-04-14

    Acquired Immunodeficiency Syndrome; Blood Donors; Blood Transfusion; HIV Infections; HIV-1; HIV-2; HTLV-I; HTLV-II; Retroviridae Infections; Hepatitis, Viral, Human; Hepatitis B; Hepacivirus; West Nile Virus

  8. Quininium tetra-chloridozinc(II).

    PubMed

    Chen, Li-Zhuang

    2009-09-05

    The asymmetric unit of the title compound {systematic name: 2-[hydr-oxy(6-meth-oxy-quinolin-1-ium-4-yl)meth-yl]-8-vinyl-quinuclidin-1-ium tetra-chlorido-zinc(II)}, (C(20)H(26)N(2)O(2))[ZnCl(4)], consists of a double proton-ated quininium cation and a tetra-chloridozinc(II) anion. The Zn(II) ion is in a slightly distorted tetra-hedral coordination environment. The crystal structure is stabilized by inter-molecular N-H⋯Cl and O-H⋯Cl hydrogen bonds.

  9. The Monomeric Pentacyanocobaltate (II) Anion.

    ERIC Educational Resources Information Center

    Mosha, Donnati M. S.

    1982-01-01

    Laboratory procedures, background information, and discussion of experimental results are provided for the preparation of Thallium (I) Pentacyanocobaltate (II). The preparation of this pale green salt is carried out in an aqueous medium. (Author/JN)

  10. Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases

    PubMed Central

    Jaffery, Maimoon F.; Supuran, Claudiu T.

    2001-01-01

    Schiff bases were obtained by condensation of 2-amino-l,3,4-thiadiazole with 5-substituted-salicylaldehydes which were further used to obtain complexes of the type [M(L)2]Cl2, where M=Co(II), Cu(II), Ni(II) or Zn(II). The new compounds described here have been characterized by physical, spectral and analytical data, and have been screened for antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of these Schiff bases increased upon chelation/complexation, against the tested bacterial species, opening new aproaches in the fight against antibiotic resistant strains. PMID:18475981

  11. Preparation, characterization and biological activity of Fe(III), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO 2(II) complexes of new cyclodiphosph(V)azane of sulfaguanidine

    NASA Astrophysics Data System (ADS)

    Sharaby, Carmen M.

    2005-11-01

    Novel hexachlorocyclodiphosph(V)azane of sulfaguanidine, H 4L, l,3-[ N'-amidino-sulfanilamide]-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane was prepared and its coordination behaviour towards the transition metal ions Fe(III), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO 2(II) was studied. The structures of the isolated products are proposed based on elemental analyses, IR, UV-vis, 1H NMR, mass spectra, reflectance, magnetic susceptibility measurements and thermogravimetric analysis (TGA). The hyperfine interactions in the isolated complex compounds were studied using 14.4 keV γ-ray from radioactive 57Co (Mössbauer spectroscopy). The data show that the ligand are coordinated to the metal ions via the sulfonamide O and deprotonated NH atoms in an octahedral manner. The H 4L ligand forms complexes of the general formulae [(MX z) 2(H 2L)H 2O) n] and [(FeSO 4) 2 (H 4L) (H 2O) 4], where X = NO 3 in case of UO 2(II) and Cl in case of Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II). The molar conductance data show that the complexes are non-electrolytes. The thermal behaviour of the complexes was studied and different thermodynamic parameters were calculated using Coats-Redfern method. Most of the prepared complexes showed high bactericidal activity and some of the complexes show more activity compared with the ligand and standards.

  12. Optical Waveguide Scattering Reduction. II.

    DTIC Science & Technology

    1980-12-01

    FAD-AOAR 815 BATTELLEWCOLUMBUS LABS ON F/S 20/6 OPTICAL WAVEGUIDE SCATTER ING REDUC TION. II.(U) 7 DEC 80 0 W VAHEY, N F HARTMAN, R C SHERMAN F3361... OPTICAL WAVEGUIDE SCATTERING REDUCTION II M BATTELLE COLUMBUS LABORATORIES 505 KING AVENUE COLUMBUS, OHIO 43201 DTIC ELECTEf MAY 12 198111 December...reviewed and is approved for publication. DOUGLAS AWIWILLE, Project Engineer KENNETH R. HUTCHINSON, Chief Electro- Optics Techniques and Electro- Optics

  13. Exploring redox-mediating characteristics of textile dye-bearing microbial fuel cells: thionin and malachite green.

    PubMed

    Chen, Bor-Yann; Xu, Bin; Qin, Lian-Jie; Lan, John Chi-Wei; Hsueh, Chung-Chuan

    2014-10-01

    Prior studies indicated that biodecolorized intermediates of azo dyes could act as electron shuttles to stimulate wastewater decolorization and bioelectricity generation (WD&BG) in microbial fuel cells (MFCs). This study tended to explore whether non-azo textile dyes (i.e., thionin and malachite green) could also own such redox-mediating capabilities for WD&BG. Prior findings mentioned that OH and/or NH2 substitute-containing auxochrome compounds (e.g., 2-aminophenol and 1,2-dihydroxybenzene) could effectively mediate electron transport in MFCs for simultaneous WD&BG. This work clearly suggested that the presence of electron-mediating textile dyes (e.g., thionin and malachite green (MG)) in MFCs is promising to stimulate color removal and bioelectricity generation. That is, using MFCs as operation strategy for wastewater biodecolorization is economically promising in industrial applications due to autocatalytic acceleration of electron-flux for WD&BG in MFCs.

  14. Determination of Fe(II)Fe(II) ratio in glass

    SciTech Connect

    Baumann, E.W.

    1989-07-26

    The procedure was designed for the simple, rapid determination of the Fe(II)/Fe(III) ratio in glass samples. The procedure consists of the following steps: dissolution of the pulverized glass sample in a sulfuric-hydrofluoric acid mixture, containing ammonium vanadate, which preserves the Fe(II) content; addition of boric acid to destroy iron-fluoride complexes, making the iron available for color formation with Ferrozine; addition of pH 5 buffer and Ferrozine reagent to form the magenta-colored ferrous-Ferrozine complex, with measurement of the absorbance for the determination of Fe(II) content; and, addition of ascorbic acid to reduce Fe(III) to Fe(II), with a second absorbance measurement that determines total Fe. Directions for the preparation of glass from non-radioactive sludge samples are provided. The analysis of this prepared glass for the Fe(II)/Fe(III) ratio is an indication of the ratio that would be in a plant batch of glass if made from this sludge.

  15. Adsorption of Cu(II), Ni(II) and Zn(II) on modified jute fibres.

    PubMed

    Shukla, S R; Pai, Roshan S

    2005-09-01

    The potential of a lignocellulosic fibre, jute, was assessed for adsorption of heavy metal ions like Cu(II), Ni(II) and Zn(II) from their aqueous solutions. The fibre was also used as adsorbent after chemically modifying it by two different techniques viz, loading of a dye with specific structure, C.I. Reactive Orange 13, and oxidising with hydrogen peroxide. Both the modified jute fibres gave higher metal ion adsorption. Thus, the dye loaded jute fibres showed metal ion uptake values of 8.4, 5.26 and 5.95 mg/g for Cu(II), Ni(II) and Zn(II), respectively, while the corresponding values for oxidised jute fibres were 7.73, 5.57 and 8.02 mg/g, as against 4.23, 3.37 and 3.55 mg/g for unmodified jute fibres. Adsorption isotherm models indicated best fit for Langmuir model for the modified jute fibres. The adsorption values decreased with lowering of pH. The desorption efficiency, regenerative and reuse capacity of these adsorbents were also assessed for three successive adsorption-desorption cycles. The adsorptive capacity was retained only when the caustic soda regeneration is carried out as an intermediate step after desorption. Possible mechanism has been given.

  16. The CDF SVX II upgrade for the Tevatron Run II

    SciTech Connect

    Bortoletto, Daniela

    1997-04-01

    A microstrip silicon detector SVX II has been proposed for the upgrade of CDF to be installed in 1999 for Run II of the Tevatron. Three barrels of five layers of double-sided silicon microstrip detectors will cover the interaction region. A description of the project status will be presented. Emphasis will be given to the R&D program for silicon sensors which includes capacitance minimization, the study of coupling capacitor integrity, the operation of the detectors in conjunction with the SVXH and SVX2 readout chips in two beam tests and the determination of the detectors performance deterioration due to radiation damage.

  17. BEATRIX-II, phase II: Data summary report

    SciTech Connect

    Slagle, O.D.; Hollenberg, G.W.

    1996-05-01

    The BEATRIX-II experimental program was an International Energy Agency sponsored collaborative effort between Japan, Canada, and the United States to evaluate the performance of ceramic solid breeder materials in a fast-neutron environment at high burnup levels. This report addresses the Phase II activities, which included two in situ tritium-recovery canisters: temperature-change and temperature-gradient. The temperature-change canister contained a Li{sub 2}O ring specimen that had a nearly uniform temperature profile and was capable of temperature changes between 530 and 640{degrees}C. The temperature-gradient canister contained a Li{sub 2}ZrO{sub 3} pebble bed operating under a thermal gradient of 440 to 1100{degrees}C. Postirradiation examination was carried out to characterize the Phase II in situ specimens and a series of nonvented capsules designed to address the compatibility of beryllium with lithium-ceramic solid-breeder materials. The results of the BEATRIX-II, Phase II, irradiation experiment provided an extensive data base on the in situ tritium-release characteristics of Li{sub 2}O and Li{sub 2}ZrO{sub 3} for lithium burnups near 5%. The composition of the sweep gas was found to be a critical parameter in the recovery of tritium from both Li{sub 2}O and Li{sub 2}ZrO{sub 3}. Tritium inventories measured confirmed that Li{sub 2}O and Li{sub 2}ZrO{sub 3} exhibited very low tritium retention during the Phase II irradiation. Tritium inventories in Li{sub 2}ZrO{sub 3} after Phase II tended to be larger than those found for Li{sub 2}ZrO{sub 3} in other in situ experiments, but the larger values may reflect the larger generation rates in BEATRIX-II. A series of 20 capsules was irradiated to determine the compatibility of lithium ceramics and beryllium under conditions similar to a fusion blanket. It is concluded that Li{sub 2}O and Li{sub 2}ZrO{sub 3} should remain leading candidates for use in a solid-breeder fusion-blanket application.

  18. EBR-II Data Digitization

    SciTech Connect

    Yoon, Su-Jong; Rabiti, Cristian; Sackett, John

    2014-08-01

    1. Objectives To produce a validation database out of those recorded signals it will be necessary also to identify the documents need to reconstruct the status of reactor at the time of the beginning of the recordings. This should comprehends the core loading specification (assemblies type and location and burn-up) along with this data the assemblies drawings and the core drawings will be identified. The first task of the project will be identify the location of the sensors, with respect the reactor plant layout, and the physical quantities recorded by the Experimental Breeder Reactor-II (EBR-II) data acquisition system. This first task will allow guiding and prioritizing the selection of drawings needed to numerically reproduce those signals. 1.1 Scopes and Deliverables The deliverables of this project are the list of sensors in EBR-II system, the identification of storing location of those sensors, identification of a core isotopic composition at the moment of the start of system recording. Information of the sensors in EBR-II reactor system was summarized from the EBR-II system design descriptions listed in Section 1.2.

  19. The Belle II Physics Program

    NASA Astrophysics Data System (ADS)

    Piilonen, Leo; Belle Collaboration, II

    2017-01-01

    The Belle II experiment at the asymmetric e+e- SuperKEKB collider is a major upgrade of the Belle experiment, which ran at the KEKB collider at the KEK laboratory in Japan. The design luminosity of SuperKEKB is 8 ×1035 cm-2 s-1, which is about 40 times higher than that of KEKB. The expected integrated luminosity of Belle II is 50 ab-1 in five years of running. The experiment will focus on searches for new physics beyond the Standard Model via high precision measurements of heavy flavor decays, and searches for rare signals. To reach these goals, the accelerator, detector, electronics, software, and computing systems are all being substantially upgraded. In this talk we discuss the physics program and the expected sensitivity to new physics of the Belle II data set.

  20. Belle II Silicon Vertex Detector

    NASA Astrophysics Data System (ADS)

    Dutta, D.; Adamczyk, K.; Aihara, H.; Angelini, C.; Aziz, T.; Babu, V.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, Ti.; Baroncelli, To.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bergauer, T.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Bulla, L.; Caria, G.; Casarosa, G.; Ceccanti, M.; Červenkov, D.; Chendvankar, S. R.; Dash, N.; De Pietro, G.; Divekar, S. T.; Doležal, Z.; Forti, F.; Friedl, M.; Hara, K.; Higuchi, T.; Horiguchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C.; Kandra, J.; Kambara, N.; Kang, K. H.; Kawasaki, T.; Kodyš, P.; Kohriki, T.; Koike, S.; Kolwalkar, M. M.; Kumar, R.; Kun, W.; Kvasnička, P.; La Licata, C.; Lanceri, L.; Lettenbicher, J.; Libby, J.; Lueck, T.; Maki, M.; Mammini, P.; Mayekar, S. N.; Mohanty, G. B.; Mohanty, S.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Pilo, F.; Profeti, A.; Rashevskaya, I.; Rao, K. K.; Rizzo, G.; Resmi, P. K.; Rozanska, M.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Seino, Y.; Shimizu, N.; Stypula, J.; Suzuki, J.; Tanaka, S.; Taylor, G. N.; Thalmeier, R.; Thomas, R.; Tsuboyama, T.; Uozumi, S.; Urquijo, P.; Vitale, L.; Watanuki, S.; Watanabe, M.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Würkner, B.; Yamamoto, H.; Yin, H.; Yoshinobu, T.; Zani, L.

    2017-02-01

    The Belle II experiment at the SuperKEKB asymmetric energy e+e‑ collider in KEK, Japan will operate at an instantaneous luminosity 40 times larger than that of its predecessor, Belle. It is built with an aim of collecting a huge amount of data (50 ab‑1 by 2025) for precise CP violation measurements and new physics search. Thus, we need an accurate vertex determination and reconstruction of low momentum tracks which will be achieved with the help of vertex detector (VXD). The Belle II VXD consists of two layers of DEPFET pixels (`Pixel Detector') and four layers of double-sided silicon microstrip sensors (`Silicon Vertex Detector'), assembled over carbon fibre ribs. In this paper, we discuss about the Belle II Silicon Vertex Detector, especially its design and key features; we also present its module (`ladder') assembly and testing procedures.

  1. NSLS-II INJECTION CONCEPT.

    SciTech Connect

    SHAFTAN, T.; PINAYEV, I.; ROSE, J.; WANG, X.J.; ET AL.

    2005-05-16

    Currently the facility upgrade project is in progress at the NSLS (at Brookhaven National Laboratory). The goal of the NSLS-II is a 3 GeV ultra-low-emittance storage ring that will increase radiation brightness by three orders of magnitude over that of the present NSLS X-ray ring. The low emittance of the high brightness ring's lattice results in a short lifetime, so that a top-off injection mode becomes an operational necessity. Therefore, the NSLS-II injection system must provide, and efficiently inject, an electron beam at a high repetition rate. In this paper, we present our concept of the NSLS-II injection system and discuss the conditions for, and constraints on, its design.

  2. Spacelab Mission Simulation-II

    NASA Technical Reports Server (NTRS)

    Sawin, C. F.; Shumate, W. H.

    1976-01-01

    The NASA Johnson Space Center conducted the second in a series of Spacelab mission simulations during the week of January 26-February 1, 1976. The facilities that supported the Spacelab Mission Simulation-II (SMS-II) included mock-ups of Spacelab, the Orbiter mid-deck and aft flight deck areas, and support areas simulating a mission control area and a payload operation control area. The SMS-II encompassed presently identified Spacelab mission requirements including experiment solicitation, evaluation, selection, and prioritization; crew selection and training; experiment hardware development, integration, and evaluation. The payload chosen included a cosmic ray physics experiment which was located on a pallet aft of the Spacelab and 20 biomedical experiments which were performed in the Spacelab. This paper will summarize simulation experience to date and list areas requiring substantial evaluation in the future.

  3. Titan II secondary payload capability

    NASA Astrophysics Data System (ADS)

    Butts, Aubrey J.; Nance, Milo; Odle, Roger C.

    Small satellite programs are often faced with the prospect of flying as a secondary payload because of size or funding considerations. This paper discusses a concept for flying such payloads on flights already scheduled on the Titan II SLV program over the next decade. The Titan II has the capability of inserting over 4200 lbs into LEO and larger payloads on ballistic trajectories from which higher orbits can be achieved when kick motors are used. Orbit changes are possible depending on the specific altitudes and payloads involved. Of the existing 13 remaining missions currently scheduled to fly on the Titan II SLV, excess performance is available on several missions that could be used to insert secondary payloads of up to 3000 lbs into their final orbit. This paper outlines an approach that would implement a secondary payload mission and allow small satellites to schedule a launch at a predetermined date through the year 2000.

  4. A new chelating resin for preconcentration and determination of Mn(II), Ni(II), Cu(II), Zn(II), Cd(II), and Pb(II) by flame atomic absorption spectrometry.

    PubMed

    Maheswari, Mohan A; Subramanian, Mandakolathur S

    2003-01-01

    A new polychelatogen, AXAD-16-1,2-diphenylethanolamine, was developed by chemically modifying Amberlite XAD-16 with 1,2-diphenylethanolamine to produce an effective metal-chelating functionality for the preconcentration of Mn(II), Ni(II), Cu(II), Zn(II), Cd(II), and Pb(II) and their determination by flame atomic absorption spectrometry. Various physiochemical parameters that influence the quantitative preconcentration and recovery of metal were optimized by both static and dynamic techniques. The resin showed superior extraction efficiency with high-metal loading capacity values of 0.73, 0.80, 0.77, 0.87, 0.74, and 0.81 mmol/g for Mn(II), Ni(II), Cu(II), Zn(II), Cd(II), and Pb(II), respectively. The system also showed rapid metal-ion extraction and stripping, with complete saturation in the sorbent phase within 15 min for all the metal ions. The optimum condition for effective metal-ion extraction was found to be a neutral pH, which is a great advantage in the preconcentration of trace metal ions from natural water samples without any chemical pretreatment of the sample. The resin also demonstrated exclusive ion selectivity toward targeted metal ions by showing greater resistivity to various complexing species and more common metal ions during analyte concentration, which ultimately led to high preconcentration factors of 700 for Cu(II); 600 for Mn(II), Ni(II), and Zn(II); and 500 for Cd(II) and Pb(II), arising from a larger sample breakthrough volume. The lower limits of metal-ion detection were 7 ng/mL for Mn(II) and Ni(II); 5 ng/mL for Cu(II), Zn(II), and Cd(II), and 10 ng/mL for Pb(II). The developed resin was successful in preconcentrating metal ions from synthetic and real water samples, multivitamin-multimineral tablets, and curry leaves (Murraya koenigii) with relative standard deviations of < or = 3.0% for all analytical measurements, which demonstrated its practical utility.

  5. Administrative Plans. STIP II (Skill Training Improvement Programs Round II).

    ERIC Educational Resources Information Center

    Los Angeles Community Coll. District, CA.

    Personnel policies, job responsibilities, and accounting procedures are summarized for the Los Angeles Community College District's Skill Training Improvement Programs (STIP II). This report first cites references to the established personnel and affirmative action procedures governing the program and then presents an organizational chart for the…

  6. Propulsion Systems for Aircraft. Aerospace Education II. Instructional Unit II.

    ERIC Educational Resources Information Center

    Elmer, James D.

    This curriculum guide accompanies another publication in the Aerospace Education II series entitled "Propulsion Systems for Aircraft." The guide includes specific guidelines for teachers on each chapter in the textbook. Suggestions are included for objectives (traditional and behavioral), suggested outline, orientation, suggested key…

  7. Helium II level measurement techniques

    NASA Astrophysics Data System (ADS)

    Celik, D.; Hilton, D. K.; Zhang, T.; Van Sciver, S. W.

    2001-05-01

    In this paper, a survey of cryogenic liquid level measurement techniques applicable to superfluid helium (He II) is given. The survey includes both continuous and discrete measurement techniques. A number of different probes and controlling circuits for this purpose have been described in the literature. They fall into one of the following categories: capacitive liquid level gauges, superconducting wire liquid level gauges, thermodynamic (heat transfer-based) liquid level gauges, resistive gauges, ultrasound and transmission line-based level detectors. The present paper reviews these techniques and their suitability for He II service. In addition to these methods, techniques for measuring the total liquid volume and mass gauging are also discussed.

  8. Belle II Early Physics Program

    NASA Astrophysics Data System (ADS)

    Stottler, Zachary; Belle Collaboration, II

    2017-01-01

    The Belle II experiment at the SuperKEKB collider is a major upgrade of the KEK `` B factory'' facility in Tsukuba, Japan. First beams are planned for early 2017 and first physics data will be recorded in the middle of 2018 during Phase 2 commissioning, while the Belle II detector is still missing its vertex detector system. In this talk we describe the physics program for this early data. The program will focus on bottomonium spectroscopy at different center-of-mass energies, in particular at the ϒ(3 S) and ϒ(6 S) resonances, amongst other energy points.

  9. Distributed Computing at Belle II

    NASA Astrophysics Data System (ADS)

    Bansal, Vikas; Belle Collaboration, II

    2016-03-01

    The Belle II experiment at the SuperKEKB collider in Tsukuba, Japan, will start physics data taking in 2018 and will accumulate 50 ab-1 of e+e- collision data, about 50 times larger than the data set of the earlier Belle experiment. The computing requirements of Belle II are comparable to those of a RUN I high-pT LHC experiment. Computing will make full use of high speed networking and of the Computing Grids in North America, Asia and Europe. Results of an initial MC simulation campaign with 5 ab-1 equivalent luminosity will be described.

  10. The PEP-II design

    SciTech Connect

    Sullivan, M.K.

    1995-05-01

    The Stanford Linear Accelerator Center (SLAC), Lawrence Berkeley Laboratory (LBL), Lawrence Livermore National Laboratory (LLNL) Positron Electron Project-II (PEP-II) is a design for a high-luminosity, asymmetric energy, electron-positron colliding beam accelerator that will operate at the center-of-mass energy of the {Upsilon}4S (10.58 GeV). The goal of the design is to achieve a large enough integrated luminosity with a moving center-of-mass reference frame to he able to observe the predicted rare decay modes of the {Upsilon}4S that do not conserve charge parity (CP).

  11. First results from SAGE II

    SciTech Connect

    Abdurashitov, J.N.; Faizov, E.L.; Gavrin, V.N.

    1994-07-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76{sub {minus}18}{sup +21} (stat) {sub {minus}7}{sup +5} (sys) SNU. combined with the SAGE I result, the capture rate is 74{sub {minus}12}{sup +13} (stat) {sub {minus}7}{sup +5} (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models.

  12. Nickel(II) Complex of a Hexadentate Ligand with Two o-Iminosemiquinonato(1-) π-Radical Units and Its Monocation and Dication.

    PubMed

    Ali, Akram; Dhar, Debanjan; Barman, Suman K; Lloret, Francesc; Mukherjee, Rabindranath

    2016-06-20

    Aerobic reaction of a hexadentate redox-active o-aminophenol-based ligand, H4L(3) = N,N'-bis(2-hydroxy-3,5-di-tert-butylphenyl)-2,2'-diamino(diphenyldithio)-ethane, in CH3OH with Ni(II)(O2CCH3)2·4H2O and Et3N afforded isolation of a reddish-brown crystalline solid [Ni(L(3))] 1. Cyclic voltammetry (CV) experiment exhibits two oxidative responses at E1/2 = 0.09 and 0.53 V vs SCE (saturated calomel electrode). Chemical oxidation of 1 in air by [Fe(III)(η(5)-C5H5)2][PF6] and AgBF4 in CH2Cl2 led to the isolation of one-electron oxidized species [1](1+) as purple [1][PF6]·CH2Cl2 and two-electron oxidized species [1](2+) as dark purple [1][BF4]2·CH2Cl2, respectively. X-ray crystallographic analysis at 100(2) K unambiguously established that the ligand is present in [Ni(II){(L(ISQ)O,N)(•-)}{(L(ISQ)O,N)(•-)}{(LS,S)(0)}] 1, [Ni(II){(L(IBQ)O,N)(0)}{(L(ISQ)O,N)(•-)}{(LS,S)(0)}][PF6]·CH2Cl2, and [Ni(II){(L(IBQ)O,N)(0)}{(L(IBQ)O,N)(0)}{(LS,S)(0)}][BF4]2·CH2Cl2, as monoanionic o-iminosemiquinonate(1-) π-radical (Srad = 1/2) (L(ISQ))(•-) and neutral o-iminoquinone (L(IBQ))(0) redox-levels. Complexes 1, [1][PF6]·CH2Cl2, and [1][BF4]2·CH2Cl2 possess an S = 2, 3/2, and 1 ground-state, respectively, established by temperature-dependent (2-300 K) magnetic behavior of 1 and [1][PF6]·CH2Cl2, and a μeff value of [1][BF4]2·CH2Cl2 at 300 K. Both 1 and [1][PF6]·CH2Cl2 exhibit ferromagnetic exchange-coupling between the two electrons of Ni(II) and two/one ligand π-radicals, respectively. The redox processes are shown to be ligand-based. Spectroscopic and redox properties, and density functional theory (DFT) calculations at the CAM-B3LYP-level of theory adequately describe the electronic structure of 1, [1](1+), and [1](2+). The observed UV-vis-NIR absorptions for 1, [1][PF6]·CH2Cl2, and [1][BF4]2·CH2Cl2 have been assigned, based on time-dependent (TD)-DFT calculations.

  13. Preparation and characterization of multi-carboxyl-functionalized silica gel for removal of Cu (II), Cd (II), Ni (II) and Zn (II) from aqueous solution

    NASA Astrophysics Data System (ADS)

    Li, Min; Li, Ming-yu; Feng, Chang-gen; Zeng, Qing-xuan

    2014-09-01

    In this paper, the multi-carboxyl-functionalized silica gel was prepared by surface grafting method and applied for the removal of Cu (II), Cd (II), Ni (II) and Zn (II) from aqueous solution. The adsorbent was characterized by FT-IR, thermogravimetry, Brunauer-Emmett-Teller surface area measurement and elemental analysis, and it proved that the organic functional group, carboxyl group, was grafted successfully onto the silica gel surface. The effect of solution pH on removal efficiencies of Cu (II), Cd (II), Ni (II) and Zn (II) was investigated and it was found that with the exception of Zn (II), the removal efficiencies of the rest of metal ions increased with the increasing of pH in the solution, the maximum removal efficiency occurred at pH 6.0, whereas the maximum removal efficiency for Zn (II) was found to be at pH 7.0. Adsorption equilibrium data were well fitted to Langmuir than Freundlich isotherm model and the maximum adsorption capacity for Cu (II), Cd (II), Ni (II) and Zn (II) was 47.07, 41.48, 30.80 and 39.96 mg/g, respectively. Competitive adsorption experiments demonstrated that the adsorbent material had excellent adsorption amount and high affinity for the Cu (II) in the binary systems. In addition, the column experiments were used to investigate stability and reusability of the adsorbent, the dynamic adsorption performance, and desorption of metal ions absorbed from the adsorbent. The results confirmed that the adsorbent presents good dynamic adsorption performance for Cu (II), Cd (II), Ni (II) and Zn (II) and these metal ions adsorbed were easy to be desorbed from the adsorbent. The adsorption capacities of metal ions did not present an obvious decrease after five cycles of adsorption-desorption.

  14. Electromagnetic calorimeter for Belle II

    NASA Astrophysics Data System (ADS)

    Belle-ECL; Aulchenko, V.; Bobrov, A.; Bondar, A.; Cheon, B. G.; Eidelman, S.; Epifanov, D.; Garmash, Yu; Goh, Y. M.; Kim, S. H.; Krokovny, P.; Kuzmin, A.; Lee, I. S.; Matvienko, D.; Miyabayashi, K.; Nakamura, I.; Shebalin, V.; Shwartz, B.; Unno, Y.; Usov, Yu; Vinokurova, A.; Vorobjev, V.; Zhilich, V.; Zhulanov, V.

    2015-02-01

    The electromagnetic calorimeter of the BELLE II detector for experiments at Super B-factory SuperKEKB is briefly described. The project of the calorimeter upgrade to meet severe background conditions expected at the upgraded KEK B factory is presented.

  15. Solar Ca II K Observations

    NASA Astrophysics Data System (ADS)

    Bertello, Luca; Pevtsov, Alexei A.; Tlatov, Andrey; Singh, Jagdev

    2016-07-01

    Some of the most important archives of past and current long-term solar synoptic observations in the resonance line of Ca II K are described here. These observations are very important for understanding the state of the solar magnetism on time scales up to several decades. The first observations of this kind began in 1904 at the Kodaikanal Observatory (India), followed by similar programs at different other locations. Regular full-disk Ca II K monitoring programs started in 1915 at the Mount Wilson Observatory (USA) and in 1917 at the National Solar Observatory of Japan. Beginning in 1919 and in 1926 regular observations were taken also at the Paris-Meudon Observatory (France) and at the "Donati solar tower telescope of the Arcetri Astrophysical Observatory in Italy, respectively. In 1926 the the Astronomical Observatory of the Coimbra University in Portugal started its own program of Ca II K observations. Although some of these programs have been terminated over the years, their data archives constitute a unique resource for studies of solar variability. In the early 1970s, the National Solar Observatory (NSO) at Sacramento Peak (USA) started a new program of daily Sun-as-a-star observations in the Ca II K line. Today the NSO is continuing these observations through its Synoptic Optical Long-term Investigations of the Sun (SOLIS) facility.

  16. The Bender-Gestalt II.

    PubMed

    Brannigan, Gary G; Decker, Scott L

    2006-01-01

    In 2003, the Bender-Gestalt II was published. In the present article, the revision process is described, and major changes to the test are discussed. These changes include additional designs, a memory (recall) phase, Motor and Perception supplementary tests, a detailed observation form, a global scoring system, and a large, nationally representative normative base. Directions for future research are also provided.

  17. National Synchrotron Light Source II

    SciTech Connect

    Hill, John; Dooryhee, Eric; Wilkins, Stuart; Miller, Lisa; Chu, Yong

    2016-04-25

    NSLS-II is a synchrotron light source helping researchers explore solutions to the grand energy challenges faced by the nation, and open up new regimes of scientific discovery that will pave the way to discoveries in physics, chemistry, and biology — advances that will ultimately enhance national security and help drive the development of abundant, safe, and clean energy technologies.

  18. Tech Area II: A history

    SciTech Connect

    Ullrich, R.

    1998-07-01

    This report documents the history of the major buildings in Sandia National Laboratories` Technical Area II. It was prepared in support of the Department of Energy`s compliance with Section 106 of the National Historic Preservation Act. Technical Area II was designed and constructed in 1948 specifically for the final assembly of the non-nuclear components of nuclear weapons, and was the primary site conducting such assembly until 1952. Both the architecture and location of the oldest buildings in the area reflect their original purpose. Assembly activities continued in Area II from 1952 to 1957, but the major responsibility for this work shifted to other sites in the Atomic Energy Commission`s integrated contractor complex. Gradually, additional buildings were constructed and the original buildings were modified. After 1960, the Area`s primary purpose was the research and testing of high-explosive components for nuclear weapons. In 1994, Sandia constructed new facilities for work on high-explosive components outside of the original Area II diamond-shaped parcel. Most of the buildings in the area are vacant and Sandia has no plans to use them. They are proposed for decontamination and demolition as funding becomes available.

  19. National Synchrotron Light Source II

    ScienceCinema

    Hill, John; Dooryhee, Eric; Wilkins, Stuart; Miller, Lisa; Chu, Yong

    2016-07-12

    NSLS-II is a synchrotron light source helping researchers explore solutions to the grand energy challenges faced by the nation, and open up new regimes of scientific discovery that will pave the way to discoveries in physics, chemistry, and biology — advances that will ultimately enhance national security and help drive the development of abundant, safe, and clean energy technologies.

  20. NSLS-II RF SYSTEMS

    SciTech Connect

    Rose, J.; Gash, W.; Holub, B.; Kawashima, Y.; Ma, H.; Towne, N.; Yeddulla, M.

    2011-03-28

    The NSLS-II is a new third generation light source being constructed at Brookhaven Lab. The storage ring is optimized for low emittance by use of damping wigglers to reduce the emittance to below 1 nm-rad. The RF systems are designed to provide stable beam through tight RF phase and amplitude stability requirements.

  1. 40 K Fastrac II Test

    NASA Technical Reports Server (NTRS)

    1997-01-01

    A 40 K Fastrac II duration test performed at Marshall Test Stand 116. The purpose of this test was to gauge the length of time between contact of TEA (Triethylenealuminum) and LOX (liquid oxygen) as an ignitor for the Fastrac engine.

  2. Achondrogenesis type II with polydactyly.

    PubMed

    Rittler, M; Orioli, I M

    1995-11-06

    We report on a newborn male infant who presented the typical findings of achondrogenesis type II (Langer-Saldino), and who also showed postaxial polydactyly on both feet and bilateral microtia. Polydactyly is frequently part of the short-rib syndromes, but has not been reported in achondrogenesis. The hypothesis of polydactyly as part of a contiguous gene syndrome is discussed.

  3. Military Aerospace. Aerospace Education II.

    ERIC Educational Resources Information Center

    Smith, J. C.

    This book is a revised publication in the series on Aerospace Education II. It describes the employment of aerospace forces, their methods of operation, and some of the weapons and equipment used in combat and combat support activities. The first chapter describes some of the national objectives and policies served by the Air Force in peace and…

  4. Application Programming in AWIPS II

    NASA Technical Reports Server (NTRS)

    Smit, Matt; McGrath, Kevin; Burks, Jason; Carcione, Brian

    2012-01-01

    Since its inception almost 8 years ago, NASA's Short-term Prediction Research and Transition (SPoRT) Center has integrated NASA data into the National Weather Service's decision support system (DSS) the Advanced Weather Interactive Processing System (AWIPS). SPoRT has, in some instances, had to shape and transform data sets into various formats and manipulate configurations to visualize them in AWIPS. With the advent of the next generation of DSS, AWIPS II, developers will be able to develop their own plugins to handle any type of data. Raytheon is developing AWIPS II to be a more extensible package written mainly in Java, and built around a Service Oriented Architecture. A plugin architecture will allow users to install their own code modules, and (if all the rules have been properly followed) they will work hand-in-hand with AWIPS II as if it were originally built in. Users can bring in new datasets with existing plugins, tweak plugins to handle a nuance or desired new functionality, or create an entirely new visualization layout for a new dataset. SPoRT is developing plugins to ensure its existing NASA data will be ready for AWIPS II when it is delivered, and to prepare for the future of new instruments on upcoming satellites.

  5. Comparative studies of aerosol extinction measurements made by the SAM II and SAGE II satellite experiments

    NASA Technical Reports Server (NTRS)

    Yue, Glenn K.; Mccormick, M. P.; Chu, W. P.; Wang, P.; Osborn, M. T.

    1989-01-01

    Results from the Stratospheric Aerosol Measurement (SAM) II and Stratospheric Aerosol and Gas Experiment (SAGE) II are compared for measurement locations which are coincident in time and space. At 1.0 micron, the SAM II and SAGE II aerosol extinction profiles are similar within their measurement errors. In addition, sunrise and sunset aerosol extinction data at four different wavelengths are compared for occasions when the SAGE II and SAM II measurements are nearly coincident in space and about 12 hours apart.

  6. Synthesis, spectroscopic, antimicrobial and DNA cleavage studies of new Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes with naphthofuran-2-carbohydrazide Schiff base

    NASA Astrophysics Data System (ADS)

    Halli, Madappa B.; Sumathi, R. B.

    2012-08-01

    A series of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes have been synthesized with newly synthesized Schiff base derived from naphthofuran-2-carbohydrazide and cinnamaldehyde. The elemental analyses of the complexes are confined to the stoichiometry of the type MLCl2 [M = Co(II) and Cu(II)], ML2Cl2 [M = Ni(II), Cd(II), Zn(II) and Hg(II)] respectively, where L is Schiff base ligand. Structures have been proposed from elemental analyses, IR, electronic, mass, 1H NMR, ESR spectral data, magnetic, and thermal studies. The measured low molar conductance values in DMF indicate that the complexes are non-electrolytes. Spectroscopic studies suggest coordination occurs through azomethine nitrogen and carbonyl oxygen of the ligand with the metal ions. The Schiff base and its complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal (Aspergillus niger, Aspergillus flavus, Cladosporium and Candida albicans) activities by minimum inhibitory concentration (MIC) method. The DNA cleavage studies by agarose gel electrophoresis method was studied for all the complexes.

  7. Epilepsy Care in Developing Countries: Part II of II

    PubMed Central

    Birbeck, Gretchen L

    2010-01-01

    Although 80% of people with epilepsy reside in resource poor, developing countries, epilepsy care in these regions remains limited and the majority of epilepsy patients go untreated. Cost-effective, sustainable epilepsy care services, delivering first-line antiepileptic drugs through established primary health care facilities, are needed to decrease these treatment gaps. Neurologists with local experience and knowledge of the culture, who are willing to serve as educators, policy advisors, and advocates, can make a difference. This is Part II of a two-part article. Part I reviewed the burden of epilepsy and the current state of resources for treatment in developing countries, while Part II will now discuss various aspects of care in these countries. PMID:20944819

  8. Sloan Digital Sky Survey II (SDSS-II) Supernova Data

    DOE Data Explorer

    The Sloan Digital Sky Survey (SDSS) is a series of three interlocking imaging and spectroscopic surveys, carried out over an eight-year period with a dedicated 2.5m telescope located at Apache Point Observatory in Southern New Mexico. The SDSS Supernova Survey was one of those three components of SDSS and SDSS-II, a 3-year extension of the original SDSS that operated from July 2005 to July 2008. The Supernova Survey was a time-domain survey, involving repeat imaging of the same region of sky every other night, weather permitting. The primary scientific motivation was to detect and measure light curves for several hundred supernovae through repeat scans of the SDSS Southern equatorial stripe 82 (about 2.5? wide by ~120? long). Over the course of three 3-month campaigns SDSS-II SN discovered and measured multi-band lightcurves for ~500 spectroscopically confirmed Type Ia supernovae in the redshift range z=0.05-0.4. In addition, the project harvested a few hundred light curves for SNe Ia and discovered about 80 spectroscopically confirmed core-collapse supernovae (supernova types Ib/c and II).

  9. Cytotoxic copper(II), cobalt(II), zinc(II), and nickel(II) coordination compounds of clotrimazole.

    PubMed

    Betanzos-Lara, Soledad; Gómez-Ruiz, Celedonio; Barrón-Sosa, Lidia R; Gracia-Mora, Isabel; Flores-Álamo, Marcos; Barba-Behrens, Noráh

    2012-09-01

    Sixteen novel mononuclear Cu(II), Co(II), Zn(II), and Ni(II) complexes of the biologically active ligand clotrimazole (clotri) of the forms [M(clotri)(2)Cl(2)]·nH(2)O (1-4), [M(clotri)(2)Br(2)]·nH(2)O (5-7), [M(clotri)(3)Br(2)] (8), [M(clotri)(3)NO(3)]NO(3)·nH(2)O (9, 11), [M(clotri)(3)(NO(3))(2)]·nH(2)O (10), and [M(clotri)(3)(OH(2))(2)NO(3)]NO(3)·nH(2)O (12) were synthesized and fully characterized. Dinuclear [Cu(2)(clotri)(4)μ(2)-Cl(4)]·2H(2)O (1a) and [Cu(2)(clotri)(4)μ(2)-Br(2)]·2H(2)O (5b) as well as tetranuclear [Cu(4)(clotri)(4)μ(4)-Br(6)μ(4)-O] (5a) complexes were also isolated. Complexes 1-7, 9, and 11 present a tetrahedral geometry; complex 8 exhibits a pentacoordinated structure; complexes 1a, 10 and 12 an octahedral geometry. X-ray crystal structures of [Cu(clotri)(2)Cl(2)](1), [Cu(clotri)(2)(EtOH)Cl(2)](1·EtOH), [Zn(clotri)(2)Cl(2)] (3), [Zn(clotri)(2)Br(2)] (7), and [Cu(4)(clotri)(4)μ(4)-Br(6)μ(4)-O] (5a) were obtained. Complexes 1-12 were tested for cytotoxic activity against the human carcinoma cell lines HeLa (cervix-uterine), PC3 (prostate), and HCT-15 (colon) displaying IC(50) values <30 μM. Confocal microscopy and nuclear dying (DAPI) for complex 1 showed condensation of cromatin and nuclear membrane fragmentation. Immunocytochemical detection/expression of biomarkers suggests that complexes 1 and 9 induce cell death via apoptosis. TUNEL assay detected DNA fragmentation in HeLa cells, resulting from apoptotic signaling cascades induced by Cu(II) complexes 1 and 9. (1)H NMR studies of the Zn(II) complexes showed that they can bind to nucleotides.

  10. Spectral, IR and magnetic studies of Mn(II), Co(II), Ni(II) and Cu(II) complexes with pyrrole-2-carboxyaldehyde thiosemicarbazone (L).

    PubMed

    Chandra, Sulekh; Kumar, Anil

    2007-11-01

    Mn(II), Co(II), Ni(II) and Cu(II) complexes are synthesized with thiosemicarbazone (L) derived from pyrrole-2-carboxyaldehyde. These complexes are characterized by elemental analysis, molar conductance, magnetic susceptibility measurement, mass, IR, electronic and EPR spectral studies. The molar conductance measurement of the complexes in DMSO indicates that the complexes are non-electrolyte except Co(L)2(NO3)2 and Ni(L)2(NO3)2 complexes which are 1:2 electrolyte. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry may be assigned for Mn(II), Co(II) and Ni(II) complexes except Co(L)2(NO3)2 and Ni(L)2(NO3)2 which are of tetrahedral geometry. A tetragonal geometry may be suggested for Cu(II) complexes.

  11. Jefferson Lab's Trim Card II

    SciTech Connect

    Trent Allison; Sarin Philip; C. Higgins; Edward Martin; William Merz

    2005-05-01

    Jefferson Lab's Continuous Electron Beam Accelerator Facility (CEBAF) uses Trim Card I power supplies to drive approximately 1900 correction magnets. These trim cards have had a long and illustrious service record. However, some of the employed technology is now obsolete, making it difficult to maintain the system and retain adequate spares. The Trim Card II is being developed to act as a transparent replacement for its aging predecessor. A modular approach has been taken in its development to facilitate the substitution of sections for future improvements and maintenance. The resulting design has been divided into a motherboard and 7 daughter cards which has also allowed for parallel development. The Trim Card II utilizes modern technologies such as a Field Programmable Gate Array (FPGA) and a microprocessor to embed trim card controls and diagnostics. These reprogrammable devices also provide the versatility to incorporate future requirements.

  12. Belle II silicon vertex detector

    NASA Astrophysics Data System (ADS)

    Adamczyk, K.; Aihara, H.; Angelini, C.; Aziz, T.; Babu, V.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, Ti.; Baroncelli, To.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bergauer, T.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Casarosa, G.; Ceccanti, M.; Červenkov, D.; Chendvankar, S. R.; Dash, N.; Divekar, S. T.; Doležal, Z.; Dutta, D.; Enami, K.; Forti, F.; Friedl, M.; Hara, K.; Higuchi, T.; Horiguchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C. W.; Kandra, J.; Kang, K. H.; Kato, E.; Kawasaki, T.; Kodyš, P.; Kohriki, T.; Koike, S.; Kolwalkar, M. M.; Kvasnička, P.; Lanceri, L.; Lettenbicher, J.; Maki, M.; Mammini, P.; Mayekar, S. N.; Mohanty, G. B.; Mohanty, S.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Negishi, K.; Nisar, N. K.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Pilo, F.; Profeti, A.; Rashevskaya, I.; Rao, K. K.; Rizzo, G.; Rozanska, M.; Sandilya, S.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Seino, Y.; Shimizu, N.; Stypula, J.; Suzuki, J.; Tanaka, S.; Tanida, K.; Taylor, G. N.; Thalmeier, R.; Thomas, R.; Tsuboyama, T.; Uozumi, S.; Urquijo, P.; Vitale, L.; Volpi, M.; Watanuki, S.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Würkner, B.; Yamamoto, H.; Yin, H.; Yoshinobu, T.

    2016-09-01

    The Belle II experiment at the SuperKEKB collider in Japan is designed to indirectly probe new physics using approximately 50 times the data recorded by its predecessor. An accurate determination of the decay-point position of subatomic particles such as beauty and charm hadrons as well as a precise measurement of low-momentum charged particles will play a key role in this pursuit. These will be accomplished by an inner tracking device comprising two layers of pixelated silicon detector and four layers of silicon vertex detector based on double-sided microstrip sensors. We describe herein the design, prototyping and construction efforts of the Belle-II silicon vertex detector.

  13. Particle Identification at Belle II

    NASA Astrophysics Data System (ADS)

    Sandilya, S.; Belle Collaboration, II

    2016-11-01

    We report on the charged particle identification (PID) systems for the upcoming Belle II experiment. The time of propagation counter in the central region and the proximity focusing ring imaging Cherenkov counters with aerogel radiator in the forward region will be used as the PID devices. They are expected to provide a kaon identification efficiency of more than 94% at a low pion misidentification probability of 4%. The motivation for the upgrade, method and status of both systems are discussed.

  14. Sorption of lead (II), cobalt (II) and copper (II) ions from aqueous solutions by γ-MnO2 nanostructure

    NASA Astrophysics Data System (ADS)

    Chung Le, Ngoc; Van Phuc, Dinh

    2015-01-01

    Manganese dioxide γ-MnO2 was synthesized via the reduction-oxidation reaction between KMnO4 and C2H5OH at room temperature and characterized with x-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer-Emmet-Teller nitrogen adsorption (BET-N2 adsorption). The results showed that γ-MnO2 was about 10-18 nm in size and the BET surface area was about 65 m2 g-1. The feasibility of γ-MnO2 used as a low cost adsorbent for the adsorption of Pb(II), Co(II) and Cu(II) from aqueous solutions was explored. During the adsorption process, batch technique was used, and the effects of contact time and pH on adsorption efficiency under room temperature were studied. The adsorption data showed that the Freundlich, Langmuir and Redlich-Peterson isotherms are a good model for the sorption of Co(II) and Cu(II), while the Langmuir and Redlich-Peterson isotherms provide a reasonable fit to the experimental data for Pb(II). By using the Langmuir isotherm, the adsorption capacities for Pb(II), Co(II) and Cu(II) are found to be 200 mg g-1, 90.91 mg g-1 and 83.33 mg g-1, respectively. The effectiveness of γ-MnO2 in the sorption of the three metal ions from aqueous system has the order Pb(II) > Co(II) > Cu(II). Kinetic studies showed that a pseudo-second-order model was more suitable than the pseudo-first-order model. Also, the intra-particle diffusion models were used to ascertain the mechanism of the sorption process. It is concluded that γ-MnO2 can be used as an effective adsorbent for removing Pb(II), Co(II) and Cu(II) from aqueous solutions.

  15. Topaz II preliminary safety assessment

    NASA Astrophysics Data System (ADS)

    Marshall, Albert C.; Standley, Vaughn; Voss, Susan S.; Haskin, Eric

    1993-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  16. Testing the Gossamer Albatross II

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The Gossamer Albatross II is seen here during a test flight at NASA's Dryden Flight Research Center, Edwards, California. The original Gossamer Albatross is best known for completing the first completely human powered flight across the English Channel on June 12, 1979. The Albatross II was the backup craft for the Channel flight. It was fitted with a small battery-powered electric motor and flight instruments for the NASA research program in low-speed flight. NASA completed its flight testing of the Gossamer Albatross II and began analysis of the results in April, 1980. During the six week program, 17 actual data gathering flights and 10 other flights were flown here as part of the joint NASA Langley/Dryden flight research program. The lightweight craft, carrying a miniaturized instrumentation system, was flown in three configurations; using human power, with a small electric motor, and towed with the propeller removed. Results from the program contributed to data on the unusual aerodynamic, performance, stability, and control characteristics of large, lightweight aircraft that fly at slow speeds for application to future high altitude aircraft. The Albatross' design and research data contributed to numerous later high altitude projects, including the Pathfinder.

  17. PEP-II Operations Report

    SciTech Connect

    Zisman, Michael S.

    2000-11-01

    PEP-II is a two-ring asymmetric B factory operating at the Upsilon(4S) resonance. It was constructed by a SLAC-LBNL-LLNL collaboration. The collider comprises two rings, a High-Energy Ring (HER) storing 9 GeV electrons, and a Low-Energy Ring (LER) storing 3.1 GeV positrons. Commissioning of the HER began in mid-1997 and commissioning of the LER began in mid-1998. First evidence for collisions was obtained on July 23, 1998. The BaBar detector was installed in early 1999, and commissioning with the detector commenced in May 1999. By September 1999, PEP-II had reached a peak luminosity of 1.35 x 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. In the present run, which began in October 1999, the peak luminosity has reached 3.1 x 10{sup 33} cm{sup {minus}2} s{sup {minus}1} and the integrated luminosity delivered is 25 fb{sup {minus}1}. At present, PEP-II is the world's highest luminosity collider. In this paper we describe the startup experience and summarize the operational experience during fiscal year 2000 (from October 1999 through September 2000). Plan s for luminosity upgrades are briefly described.

  18. Light echoes - Type II supernovae

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.

    1987-01-01

    Type II supernovae (SNs) light curves show a remarkable range of shapes. Data have been collected for the 12 Type II SNs that have light curve information for more than four months past maximum. Contrary to previous reports, it is found that (1) the decay rate after 100 days past maximum varies by almost an order of magnitude and (2) the light curve shapes are not bimodally distributed, but actually form a continuum. In addition, it is found that the extinctions to the SNs are related to the light curve shapes. This implies that the absorbing dust is local to the SNs. The dust is likely to be part of a circumstellar shell emitted by the SN progenitor that Dwek (1983) has used to explain infrared echoes. The optical depth of the shell can get quite large. In such cases, it is found that the photons scattered and delayed by reflection off dust grains will dominate the light curve several months after peak brightness. This 'light echo' offers a straightforward explanation of the diversity of Type II SN light curves.

  19. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. )

    1993-01-10

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  20. Biosorption of Cu(II), Zn(II), Ni(II) and Pb(II) ions by cross-linked metal-imprinted chitosans with epichlorohydrin.

    PubMed

    Chen, Chia-Yun; Yang, Cheng-Yu; Chen, Arh-Hwang

    2011-03-01

    Cross-linked metal-imprinted chitosan microparticles were prepared from chitosan, using four metals (Cu(II), Zn(II), Ni(II), and Pb(II)) as templates, and epichlorohydrin as the cross-linker. The microparticles were characterized by Fourier transform infrared spectroscopy, solid state (13)C nuclear magnetic resonance spectroscopy, and energy-dispersive X-ray spectroscopy. They were used for comparative biosorption of Cu(II), Zn(II), Ni(II) and Pb(II) ions in an aqueous solution. The results showed that the sorption capacities of Cu(II), Zn(II), Ni(II), and Pb(II) on the templated microparticles increased from 25 to 74%, 13 to 46%, 41 to 57%, and 12 to 43%, respectively, as compared to the microparticles without metal ion templates. The dynamic study showed that the sorption process followed the second-order kinetic equation. Three sorption models, Langmuir, Freundlich, and Dubinin-Radushkevich, were applied to the equilibrium isotherm data. The result showed that the Langmuir isotherm equation best fitted for monolayer sorption processes. Furthermore, the microparticles can be regenerated and reused for the metal removal.

  1. 21 CFR 1308.12 - Schedule II.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Schedule II. 1308.12 Section 1308.12 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE SCHEDULES OF CONTROLLED SUBSTANCES Schedules § 1308.12 Schedule II. (a) Schedule II shall consist of the drugs and other substances,...

  2. Masfile--II Pilot Project. Final Report.

    ERIC Educational Resources Information Center

    Five Associated Univ. Libraries, Syracuse, NY.

    The report prepared for the Five Associated University Libraries (FAUL) by the Technical Information Dissemination Bureau (TIDB) at Suny-Buffalo is divided into nine sections: (1) a summary of procedures used to accomplish the specified MASFILE-II tasks; (2) a graphic comparison of the MARC-II and the MASFILE-II formats; (3) recommend…

  3. Neurofibromatosis type II presenting as vertical diplopia.

    PubMed

    Sokwala, Ahmed; Knapp, Christopher; Gottlob, Irene

    2004-09-01

    Neurofibromatosis type II (NF II) is rare and most commonly presents with hearing loss, tinnitus and/or vestibular disturbance in the third decade of life. The authors describe a rare case presenting with NF II with vertical diplopia due to IV(th) nerve palsy. The patient was otherwise asymptomatic despite multiple extensive lesions on MRI.

  4. Macrocyclic receptor showing extremely high Sr(II)/Ca(II) and Pb(II)/Ca(II) selectivities with potential application in chelation treatment of metal intoxication.

    PubMed

    Ferreirós-Martínez, Raquel; Esteban-Gómez, David; Tóth, Éva; de Blas, Andrés; Platas-Iglesias, Carlos; Rodríguez-Blas, Teresa

    2011-04-18

    Herein we report a detailed investigation of the complexation properties of the macrocyclic decadentate receptor N,N'-Bis[(6-carboxy-2-pyridil)methyl]-4,13-diaza-18-crown-6 (H(2)bp18c6) toward different divalent metal ions [Zn(II), Cd(II), Pb(II), Sr(II), and Ca(II)] in aqueous solution. We have found that this ligand is especially suited for the complexation of large metal ions such as Sr(II) and Pb(II), which results in very high Pb(II)/Ca(II) and Pb(II)/Zn(II) selectivities (in fact, higher than those found for ligands widely used for the treatment of lead poisoning such as ethylenediaminetetraacetic acid (edta)), as well as in the highest Sr(II)/Ca(II) selectivity reported so far. These results have been rationalized on the basis of the structure of the complexes. X-ray crystal diffraction, (1)H and (13)C NMR spectroscopy, as well as theoretical calculations at the density functional theory (B3LYP) level have been performed. Our results indicate that for large metal ions such as Pb(II) and Sr(II) the most stable conformation is Δ(δλδ)(δλδ), while for Ca(II) our calculations predict the Δ(λδλ)(λδλ) form being the most stable one. The selectivity that bp18c6(2-) shows for Sr(II) over Ca(II) can be attributed to a better fit between the large Sr(II) ions and the relatively large crown fragment of the ligand. The X-ray crystal structure of the Pb(II) complex shows that the Δ(δλδ)(δλδ) conformation observed in solution is also maintained in the solid state. The Pb(II) ion is endocyclically coordinated, being directly bound to the 10 donor atoms of the ligand. The bond distances to the donor atoms of the pendant arms (2.55-2.60 Å) are substantially shorter than those between the metal ion and the donor atoms of the crown moiety (2.92-3.04 Å). This is a typical situation observed for the so-called hemidirected compounds, in which the Pb(II) lone pair is stereochemically active. The X-ray structures of the Zn(II) and Cd(II) complexes show that

  5. Pb(II), Cu(II) and Cd(II) removal through untreated rice husk; thermodynamics and kinetics.

    PubMed

    Guiso, Maria Giovanna; Alberti, Giancarla; Emma, Giovanni; Pesavento, Maria; Biesuz, Raffaela

    2012-01-01

    The sorption properties of rice husk towards Cu(II), Cd(II) and Pb(II) were studied. The sorption isotherms are described by the Langmuir equation, and Pb(II) shows a higher affinity for rice husk compared to Cu(II) and Cd(II) under the same conditions. The kinetics of sorption obeys to a pseudo second-order equation for all metals. The sorption profiles as a function of the pH were used to characterize the stoichiometry of the sorption reaction. The competition for metal complexation by any ligand in solution is also accounted for. Upon increasing the ionic strength, the sorption curves of Pb(II) move to basic pH; this shift can be explained by considering the effect of nitrate complexes on the free metal ion concentration, since KNO(3) is used as the ionic medium. An attempt to employ rice husk in a dynamic system is presented.

  6. Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro.

    PubMed Central

    Ackerman, P; Glover, C V; Osheroff, N

    1985-01-01

    The phosphorylation of Drosophila melanogaster DNA topoisomerase II by purified casein kinase II was characterized in vitro. Under the conditions used, the kinase incorporated a maximum of 2-3 molecules of phosphate per homodimer of topoisomerase II. No autophosphorylation of the topoisomerase was observed. The only amino acid residue modified by casein kinase II was serine. Apparent Km and Vmax values for the phosphorylation reaction were 0.4 microM topoisomerase II and 3.3 mumol of phosphate incorporated per min per mg of kinase, respectively. Phosphorylation stimulated the DNA relaxation activity of topoisomerase II by 3-fold over that of the dephosphorylated enzyme, and the effects of modification could be reversed by treatment with alkaline phosphatase. Therefore, this study demonstrates that post-translational enzymatic modifications can be used to modulate the interaction between topoisomerase II and DNA. Images PMID:2987912

  7. Spectroscopic and mycological studies of Co(II), Ni(II) and Cu(II) complexes with 4-aminoantipyrine derivative

    NASA Astrophysics Data System (ADS)

    Sharma, Amit Kumar; Chandra, Sulekh

    2011-10-01

    Complexes of the type [M(L)X 2], where M = Co(II), Ni(II) and Cu(II), have been synthesized with novel NO-donor Schiff's base ligand, 1,4-diformylpiperazine bis(4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) which is obtained by the acid catalyzed condensation of 1,4-diformylpiperazine with 4-aminoantipyrine. The elemental analyses, molar conductance measurements, magnetic susceptibility measurements, IR, UV, NMR, mass and EPR studies of the compounds led to the conclusion that the ligand acts as tetradentate chelate. The Schiff's base ligand forms hexacoordinated complexes having octahedral geometry for Ni(II) and tetragonal geometry for Co(II) and Cu(II) complexes. The mycological studies of the compounds were examined against the several opportunistic pathogens, i.e., Alternaria brassicae, Aspergillus niger and Fusarium oxysporum. The Cu(II) complexes were found to have most fungicidal behavior.

  8. 40 CFR Table II-1 to Subpart II of... - Emission Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table...

  9. 40 CFR Table II-1 to Subpart II of... - Emission Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table...

  10. The Practice SSAT-II. [and] Test Administration Manual for the Practice SSAT-II.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee. Student Assessment Section.

    The Florida Statewide Assessment Program provides "The Practice SSAT-II," for students who will be taking the State Student Assessment Test, Part II (SSAT-II). This practice test may be administered to tenth grade students taking the test for the first time and to eleventh and twelfth graders if they have previously failed the SSAT-II.…

  11. Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein.

    PubMed

    Jószai, Viktória; Turi, Ildikó; Kállay, Csilla; Pappalardo, Giuseppe; Di Natale, Giuseppe; Rizzarelli, Enrico; Sóvágó, Imre

    2012-07-01

    Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of four peptide fragments of human prion protein have been studied by potentiometric, UV-vis and circular dichroism spectroscopic techniques. One peptide contained three histidyl residues: HuPrP(84-114) with H85 inside and H96, H111 outside the octarepeat domain. The other three peptides contained two histidyl residues; H96 and H111 for HuPrP(91-115) and HuPrP(84-114)H85A while HuPrP(84-114)H96A contained the histidyl residues at positions 85 and 111. It was found that both histidines of the latter peptides can simultaneously bind copper(II) and nickel(II) ions and dinuclear mixed metal complexes can exist in slightly alkaline solution. One molecule of the peptide with three histidyl residues can bind two copper(II) and one nickel(II) ions. H85 and H111 were identified as the major copper(II) and H96 as the preferred nickel(II) binding sites in mixed metal species. The studies on the zinc(II)-PrP peptide binary systems revealed that zinc(II) ions can coordinate to the 31-mer PrP peptide fragments in the form of macrochelates with two or three coordinated imidazol-nitrogens but the low stability of these complexes cannot prevent the hydrolysis of the metal ion in slightly alkaline solution. These data provide further support for the outstanding affinity of copper(II) ions towards the peptide fragments of prion protein but the binding of nickel(II) can significantly modify the distribution of copper(II) among the available metal binding sites.

  12. Synthesis, spectral characterization and biological evaluation of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with thiosemicarbazone ending by pyrazole and pyridyl rings

    NASA Astrophysics Data System (ADS)

    Yousef, T. A.; Abu El-Reash, G. M.; Al-Jahdali, M.; El-Rakhawy, El-Bastawesy R.

    2014-08-01

    Here we present the synthesis of the new Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with chelating ligand (Z)-(2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene) hydrazinyl)(pyridin-2-ylamino)methanethiol. All the complexes were characterized by elemental analysis, IR, 1H NMR, UV-vis, magnetic susceptibility measurements and EPR spectral studies. IR spectra of complexes showed that the ligand behaves as NN neutral bidentate, NSN mononegative tridentate and NSNN mononegative tetradentate. The electronic spectra and the magnetic measurements suggested the octahedral geometry for all complexes as well as the EPR confirmed the tetragonal distorted octahedral for Cu(II) complex. Cd(II) complex showed the highest inhibitory antioxidant activity either using ABTS method. The SOD-like activity exhibited those Cd(II) and Zn(II) complexes have strong antioxidative properties. We tested the synthesized compounds for antitumor activity and showed that the ability to kill liver (HePG2) and breast (MCF-7) cancer cells definitely.

  13. Topoisomerase II from Human Malaria Parasites

    PubMed Central

    Mudeppa, Devaraja G.; Kumar, Shiva; Kokkonda, Sreekanth; White, John; Rathod, Pradipsinh K.

    2015-01-01

    Historically, type II topoisomerases have yielded clinically useful drugs for the treatment of bacterial infections and cancer, but the corresponding enzymes from malaria parasites remain understudied. This is due to the general challenges of producing malaria proteins in functional forms in heterologous expression systems. Here, we express full-length Plasmodium falciparum topoisomerase II (PfTopoII) in a wheat germ cell-free transcription-translation system. Functional activity of soluble PfTopoII from the translation lysates was confirmed through both a plasmid relaxation and a DNA decatenation activity that was dependent on magnesium and ATP. To facilitate future drug discovery, a convenient and sensitive fluorescence assay was established to follow DNA decatenation, and a stable, truncated PfTopoII was engineered for high level enzyme production. PfTopoII was purified using a DNA affinity column. Existing TopoII inhibitors previously developed for other non-malaria indications inhibited PfTopoII, as well as malaria parasites in culture at submicromolar concentrations. Even before optimization, inhibitors of bacterial gyrase, GSK299423, ciprofloxacin, and etoposide exhibited 15-, 57-, and 3-fold selectivity for the malarial enzyme over human TopoII. Finally, it was possible to use the purified PfTopoII to dissect the different modes by which these varying classes of TopoII inhibitors could trap partially processed DNA. The present biochemical advancements will allow high throughput chemical screening of compound libraries and lead optimization to develop new lines of antimalarials. PMID:26055707

  14. 2-line ferrihydrite: synthesis, characterization and its adsorption behaviour for removal of Pb(II), Cd(II), Cu(II) and Zn(II) from aqueous solutions.

    PubMed

    Rout, K; Mohapatra, M; Anand, S

    2012-03-21

    Nano-structured 2-line ferrihydrite was synthesized by a pH-controlled precipitation technique at 90 °C. Chemical, X-ray diffraction (XRD), Fourier transform infrared (FTIR) and Raman analyses confirmed the sample to be 2-line ferrihydrite. The nano nature of the prepared sample was studied by transmission electron microscopy (TEM). The surface area obtained by the Brunauer-Emmett-Teller (BET) method was 175.8 m(2) g(-1). The nanopowder so obtained was used to study its behaviour for the removal of Pb(II), Cd(II), Cu(II) and Zn(II) from aqueous solutions. The relative importance of experimental parameters such as solution pH, contact time and concentration of adsorbate on the uptake of various cations was evaluated. By increasing the pH from 2.0 to 5.5, adsorption of the four cations increased. The kinetics parameters were compared by fitting the contact time data to both linear as well as non-linear forms of pseudo-second-order models. Linear forms of both Langmuir and Freundlich models fitted the equilibrium data of all the cations except for Pb(II) which was also fitted to the non-linear forms of both the models as it gave a low R(2) value of 0.85 for the Langmuir model. High Langmuir monolayer capacities of 366, 250, 62.5 and 500 mg g(-1) were obtained for Pb(II), Cd(II), Cu(II) and Zn(II), respectively. Presence of chloride or sulfate had an adverse effect on cation adsorption. The interactive effects on adsorption from solutions containing two, three or four cations were studied. Surprisingly no Cd(II) adsorption was observed in Pb(II)-Cd(II), Pb(II)-Cd(II)-Zn(II) and Pb(II)-Cd(II)-Cu(II)-Zn(II) systems under the studied concentration range. The overall loading capacity of the adsorbent decreased in mixed cation systems. Metal ion loaded adsorbents were characterized by XRD, FTIR and Raman techniques. The high adsorption capability of the 2-lines ferrihydrite makes it a potentially attractive adsorbent for the removal of cations from aqueous solutions.

  15. Commissioning of NSLS-II

    SciTech Connect

    Willeke, F.

    2015-05-03

    NSLS-II, the new 3rd generation light source at BNL was designed for a brightness of 1022 photons s-1mm-2mrad-2 (0.1%BW)-1. It was constructed between 2009 and 2014. The storage ring was commissioned in April 2014 which was followed by insertion device and beamline commissioning in the fall of 2014. All ambitious design parameters of the facility have already been achieved except for commissioning the full beam intensity of 500mA which requires more RF installation. This paper reports on the results of commissioning.

  16. Zeeman effect of As II.

    NASA Technical Reports Server (NTRS)

    Li, H.; Andrew, K. L.

    1972-01-01

    Spectrograms of As electrodeless-discharge tubes operated in a field of 24,025 G have given Zeeman patterns for 232 As II spectral lines from 2361 to 10,556 A and yielded 80 Lande g factors, of which more than half are new. There is agreement between these and the g values calculated by least-squares fitting for single configurations or for multiconfigurations, where configuration interaction is noticeable. All of the measured g values as well as the energy levels are used in the fitting process.

  17. MALDI time-of-flight mass spectrometry and thermogravimetric analysis of Mg(II), Ca(II), Cu(II), Zn(II) and Pt(II) adducts with monomethoxypolyethylene glycol 5000

    NASA Astrophysics Data System (ADS)

    Mwelase, S. R.; Bariyanga, J.

    2002-05-01

    We have prepared and isolated complexes of Mg(II), Ca(II), Cu(II), Zn(II) and Pt(II) with monomethoxypolyethylene glycol 5000 in a pH 7 buffer at 40 °C in order to study the interaction of this polymer carrier with the ions likely to be found in the human body. Their characterization was done by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Fourier transform infrared, UV-Vis spectrophotometry, thermogravimetry and elemental analysis. The mass spectra allowed us to determine not only the molecular weights but also the nature of the complexes and the findings were in agreement with the elementary analysis data. The calcium ion was found not directly linked to polyethylene glycol but through water molecules. The overall results indicated strong bonding for Cu(II) and Zn(II) complexes and weak interactions for Mg(II), Ca(II) and Pt(II).

  18. Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes

    PubMed Central

    Brachet, Valérie; Raposo, Graça; Amigorena, Sebastian; Mellman, Ira

    1997-01-01

    Major histocompatibility complex class II molecules are synthesized as a nonameric complex consisting of three αβ dimers associated with a trimer of invariant (Ii) chains. After exiting the TGN, a targeting signal in the Ii chain cytoplasmic domain directs the complex to endosomes where Ii chain is proteolytically processed and removed, allowing class II molecules to bind antigenic peptides before reaching the cell surface. Ii chain dissociation and peptide binding are thought to occur in one or more postendosomal sites related either to endosomes (designated CIIV) or to lysosomes (designated MIIC). We now find that in addition to initially targeting αβ dimers to endosomes, Ii chain regulates the subsequent transport of class II molecules. Under normal conditions, murine A20 B cells transport all of their newly synthesized class II I-Ab αβ dimers to the plasma membrane with little if any reaching lysosomal compartments. Inhibition of Ii processing by the cysteine/serine protease inhibitor leupeptin, however, blocked transport to the cell surface and caused a dramatic but selective accumulation of I-Ab class II molecules in lysosomes. In leupeptin, I-Ab dimers formed stable complexes with a 10-kD NH2-terminal Ii chain fragment (Ii-p10), normally a transient intermediate in Ii chain processing. Upon removal of leupeptin, Ii-p10 was degraded and released, I-Ab dimers bound antigenic peptides, and the peptide-loaded dimers were transported slowly from lysosomes to the plasma membrane. Our results suggest that alterations in the rate or efficiency of Ii chain processing can alter the postendosomal sorting of class II molecules, resulting in the increased accumulation of αβ dimers in lysosome-like MIIC. Thus, simple differences in Ii chain processing may account for the highly variable amounts of class II found in lysosomal compartments of different cell types or at different developmental stages. PMID:9105036

  19. BNL ATF II beamlines design

    SciTech Connect

    Fedurin, M.; Jing, Y.; Stratakis, D.; Swinson, C.

    2015-05-03

    The Brookhaven National Laboratory. Accelerator Test Facility (BNL ATF) is currently undergoing a major upgrade (ATF-II). Together with a new location and much improved facilities, the ATF will see an upgrade in its major capabilities: electron beam energy and quality and CO2 laser power. The electron beam energy will be increased in stages, first to 100-150 MeV followed by a further increase to 500 MeV. Combined with the planned increase in CO2 laser power (from 1-100 TW), the ATF-II will be a powerful tool for Advanced Accelerator research. A high-brightness electron beam, produced by a photocathode gun, will be accelerated and optionally delivered to multiple beamlines. Besides the energy range (up to a possible 500 MeV in the final stage) the electron beam can be tailored to each experiment with options such as: small transverse beam size (<10 um), short bunch length (<100 fsec) and, combined short and small bunch options. This report gives a detailed overview of the ATFII capabilities and beamlines configuration.

  20. [S-II symptom questionnaire].

    PubMed

    Aleksandrowicz, J W

    2000-01-01

    "S-II" Symptom Check-list which allows for a fast diagnosis of neurotic disorders. A result of 165 points suggests the incidence of such disorders with the probability of 90%. The methodology of the construction of the check-list intends for the application of questions most common in those ill due to neurotic disorders (owing to the change in frequency) and the most possibly equal amount of questions on the symptoms common to women and men. Thanks to this the norm for women and men is identical. SCL S-II Symptom Check-list is a shortened and actualised version of the "O" Symptom Check-list, developed in 1975. It is similar to the SCL-90 and highly correlated with it, but it does not contain the variables concerning the psychotic symptoms. Thanks to this, its' accuracy (specificity) in the diagnosis of neurotic disorders is high. 4 pairs of questions allow for the judgement of answer reliability. 10 scales were singled out in the questionnaire. They are only of a helpful value and do not allow for a one-sided diagnosis of the type of the disorder, listed in the ICD-10. The scale results can, however make the correct diagnosis easier.

  1. The Spectrum of Fe II

    NASA Astrophysics Data System (ADS)

    Nave, Gillian; Johansson, Sveneric

    2013-01-01

    The spectrum of singly ionized iron (Fe II) has been recorded using high-resolution Fourier transform (FT) and grating spectroscopy over the wavelength range 900 Å to 5.5 μm. The spectra were observed in high-current continuous and pulsed hollow cathode discharges using FT spectrometers at the Kitt Peak National Observatory, Tucson, AZ and Imperial College, London and with the 10.7 m Normal Incidence Spectrograph at the National Institute of Standards and Technology. Roughly 12,900 lines were classified using 1027 energy levels of Fe II that were optimized to measured wavenumbers. The wavenumber uncertainties of lines in the FT spectra range from 10-4 cm-1 for strong lines around 4 μm to 0.05 cm-1 for weaker lines around 1500 Å. The wavelength uncertainty of lines in the grating spectra is 0.005 Å. The ionization energy of (130,655.4 ± 0.4) cm-1 was estimated from the 3d6(5D)5g and 3d6(5D)6h levels.

  2. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. . Dept. of Chemical and Nuclear Engineering)

    1992-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz 11 space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safely assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the US with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  3. [The thermodynamic molar absorptivity of coordination color reaction of indium(III) with 4,5-dihydroxybenzene-1,3-disufornic acid].

    PubMed

    Guo, Y; Chen, L; Zhang, D; Yang, D; Liu, Q

    1999-06-01

    The thermodynamic molar absorptivity of complex formed by 1:1 coordination color reaction of tiron with highly charged cation In3+ has been measured spectrophotometrically at 20.0+/-0.1 degrees C, using NaClO4 as supporting electrolyte. The influence of å on linear relation between molar absorptivity and ionic strength has been investigated. At å = 6.5, the thermodynamic molar absorptivity lg epsilon(o) was found to be 3.69.

  4. Synthesis, structural characterization, thermal and electrochemical studies of Mn(II), Co(II), Ni(II) and Cu(II) complexes containing thiazolylazo ligands

    NASA Astrophysics Data System (ADS)

    Chavan, S. S.; Sawant, V. A.

    2010-02-01

    Some thiazolylazo derivatives and their metal complexes of the type [M(L)(H 2O)Cl]; M = Mn(II), Co(II), Ni(II), Cu(II) and L = 6-(2'-thiazolylazo)-2-mercapto-quinazolin-4-one (HL 1), 6-(4'-phenyl-2'-thiazolylazo)-2-mercapto-quinazolin-4-one (HL 2), 6-(2'-thiazolylazo)-2-mercapto-3-( m-tolyl)-quinazolin-4-one (HL 3) and 6-(4'-phenyl-2'-thiazolylazo)-2-mercapto-3-( m-tolyl)-quinazolin-4-one (HL 4) have been prepared. All the complexes were characterized on the basis of elemental analysis, molar conductance, magnetic moment, IR, UV-vis, ESR, TG-DTA and powder X-ray diffraction studies. IR spectra of these complexes reveal that the complex formation occurred through thiazole nitrogen, azo nitrogen, imino nitrogen and sulfur atom of the ligands. On the basis of electronic spectral data and magnetic susceptibility measurement octahedral geometry has been proposed for the Mn(II), Co(II) and Ni(II) complexes and distorted octahedral geometry for the Cu(II) complexes. Electrochemical behavior of Ni(II) complexes exhibit quasireversible oxidation corresponding to Ni(III)/Ni(II) couple along with ligand reduction. X-ray diffraction study is used to elucidate the crystal structure of the complexes.

  5. Quiet High Speed Fan II (QHSF II): Final Report

    NASA Technical Reports Server (NTRS)

    Kontos, Karen; Weir, Don; Ross, Dave

    2012-01-01

    This report details the aerodynamic, mechanical, structural design and fabrication of a Honey Engines Quiet High Speed Fan II (lower hub/tip ratio and higher specific flow than the Baseline I fan). This fan/nacelle system incorporates features such as advanced forward sweep and an advanced integrated fan/fan exit guide vane design that provides for the following characteristics: (1) Reduced noise at supersonic tip speeds, in comparison to current state-of-the-art fan technology; (2) Improved aeroelastic stability within the anticipated operating envelope; and (3) Aerodynamic performance consistent with current state-of-the-art fan technology. This fan was fabricated by Honeywell and tested in the NASA Glenn 9- by 15-Ft Low Speed Wind Tunnel for aerodynamic, aeromechanical, and acoustic performance.

  6. Removal of Pb(II), Cd(II), Cu(II) and trichloroethylene from water by Nanofer ZVI.

    PubMed

    Eglal, Mahmoud M; Ramamurthy, Amruthur S

    2015-01-01

    Zero-valent iron nanoparticle (Nanofer ZVI) is a new reagent due to its unique structure and properties. Images of scanning electron microscopy/electron dispersive spectroscopy (SEM/EDS), transmission electron microscopy and X-ray diffraction revealed that Nanofer ZVI is stable, reactive and has a unique structure. The particles exhibited a spherical shape, a chain-like structure with a particle size of 20 to 100 nm and a surface area between 25-30 m2g(-1). The time interval for particles to agglomerate and settle was between 4-6 h. SEM/EDS Images showed that particle size increased to 2 µm due to agglomeration. Investigation of adsorption and oxidation behavior of Nanofer ZVI used for the removal of Cu(II), Pb(II), Cd(II) ions and trichloroethylene (TCE) from aqueous solutions showed that the optimal pH for Pb(II), Cu(II), Cd(II) and TCE removal were 4.5 and 4.8, 5.0 and 6.5, respectively. Test data were used to form Langmuir and Freundlich isotherms. The maximum contaminant loading was estimated as 270, 170, 110, 130 mg per gram of Nanofer ZVI for Cu(II), Pb(II), Cd(II) and TCE respectively. Removal of metal ions is interpreted in terms of their hydrated ionic radii and their electronegativity. TCE oxidation followed the dechlorination pathway resulting in nonhazardous by-products.

  7. Chelation of Cu(II), Zn(II), and Fe(II) by tannin constituents of selected edible nuts.

    PubMed

    Karamać, Magdalena

    2009-12-22

    The tannin fractions isolated from hazelnuts, walnuts and almonds were characterised by colorimetric assays and by an SE-HPLC technique. The complexation of Cu(II) and Zn(II) was determined by the reaction with tetramethylmurexide, whereas for Fe(II), ferrozine was employed. The walnut tannins exhibited a significantly weaker reaction with the vanillin/HCl reagent than hazelnut and almond tannins, but the protein precipitation capacity of the walnut fraction was high. The SE-HPLC chromatogram of the tannin fraction from hazelnuts revealed the presence of oligomers with higher molecular weights compared to that of almonds. Copper ions were most effectively chelated by the constituents of the tannin fractions of hazelnuts, walnuts and almonds. At a 0.2 mg/assay addition level, the walnut tannins complexed almost 100% Cu(II). The Fe(II) complexation capacities of the tannin fractions of walnuts and hazelnuts were weaker in comparison to that of the almond tannin fraction, which at a 2.5 mg/assay addition level, bound Fe(II) by approximately 90%. The capacity to chelate Zn(II) was quite varied for the different nut tannin fractions: almond tannins bound as much as 84% Zn(II), whereas the value for walnut tannins was only 8.7%; and for hazelnut tannins, no Zn(II) chelation took place at the levels tested.

  8. [Biosorption of Cd(II), Cu(II), Pb(II) and Zn(II) in aqueous solutions by fruiting bodies of macrofungi (Auricularia polytricha and Tremella fuciformis)].

    PubMed

    Mo, Yu; Pan, Rong; Huang, Hai-wei; Cao, Li-xiang; Zhang, Ren-duo

    2010-07-01

    Batch experiments were conducted to study the ability of fruiting bodies of Auricularia polytricha and Tremella fuciformis to adsorb Cd(II), Cu(II), Pb(II) and Zn(II) from aqueous solutions, including biosorption ability of the biomass to remove heavy metals from solutions with different concentrations, kinetics of adsorption, influence of co-cations, and biosorption affinity in multi-metalsystem. Results showed that in the solutions with individual metal, the maximum biosorption amounts of Cd(II), Cu(II), Pb(II), Zn(II) by A. polytricha were 18.91, 18.69, 20.33, 12.42 mg x g(-1), respectively, and the highest removal rates for all cases were more than 85%. The maximum biosorption amounts of Cd(II), Cu(II), Pb(II), Zn(II) by T. fuciformis were 19.98, 20.15, 19.16, 16.41 mg x g(-1), respectively, and highest removal rates for all cases were more than 75%. In the solutions with initial concentrations of 10, 50 and 100 mg x L(-1), the biosorption amounts increased but the removal rates decreased as the initial concentrations increasing. The pseudo-second-order reaction model described adsorption kinetics of heavy metal ions by fruiting bodies of A. polytricha and T. fuciformis better than the pseudo-first-order reaction model. In the solutions with multi metals, the biosorption amounts of heavy metals by two biosorbent were in the order of Ph(II) > Cd(II) > Cu(II) > Zn(II). The ions with more negative charges were preferential to be sorbed. The biosorption ability of A. polytricha was inhibited in multi-metal solutions. In multi-metal solutions, T. fuciformis sorbed a higher amount of Pb(II) but lower amounts of other three ions than that in the individual metal solutions. The results indicated that both fruiting bodies of A. polytricha and T. fuciformis were potential biosorbents.

  9. Double quantum coherence electron spin resonance on coupled Cu(II)-Cu(II) electron spins

    NASA Astrophysics Data System (ADS)

    Becker, James S.; Saxena, Sunil

    2005-10-01

    We demonstrate for the first time the ability to generate double quantum coherences (DQCs) for the case of Cu(II). We show that small splittings (˜7 MHz) from the Cu(II)-Cu(II) electron-electron magnetic dipolar interaction can be reliably resolved even though the inhomogeneously broadened Cu(II) linewidth is ˜2 GHz. A Cu(II)-Cu(II) distance of 2.0 nm was measured on a model peptide system, thus, demonstrating that distances on the nanometer scale may be measured using DQC electron spin resonance (ESR).

  10. Software Aspects of PuMa-II

    NASA Astrophysics Data System (ADS)

    Karuppusamy, R.; Stappers, B.; Stappers, B.

    2006-08-01

    The Pulsar Machine II (PuMa-II) is a state of the art pulsar machine-installed at the Westerbork Synthesis Radio Telescope (WSRT), in December 2005. PuMa-II is a flexible instrument and is designed around an ensemble of 44 high-performance computers running the Linux operating system. Much of the flexibility of PuMa-II comes from the software that is being developed for this instrument. The radio signals reaching the telescope undergo several stages of electronic and software processing before a scientifically useful data product is generated. The electronic processing of signals includes the usual RF to IF conversion, analogue to digital conversion and telescope dependent electronic digital delay compensation that happen in the signal chain of WSRT. Within PuMa-II, this data is acquired, stored and suitably processed. In this poster we present various aspects of PuMa-II software and illustrate its pulsar signal processing capabilities.

  11. Sample Exchange Evaluation (SEE) Report - Phase II

    SciTech Connect

    Winters, W.I.

    1994-09-28

    This report describes the results from Phase II of the Sample Exchange Evaluation (SEE) Program, a joint effort to compare analytical laboratory performance on samples from the Hanford Site`s high-level waste tanks. In Phase II, the program has been expanded to include inorganic constituents in addition to radionuclides. Results from Phase II that exceeded 20% relative percent difference criteria are identified.

  12. Start II, red ink, and Boris Yeltsin

    SciTech Connect

    Arbatov, A.

    1993-04-01

    Apart from the vulnerability implied by the START II treaty, it will bear the burden of the general political opposition to the Yeltsin administration. START II will be seen as part of an overall Yeltsin-Andrei Kozyrev foreign policy that is under fire for selling out Russian national interests in Yugoslavia, the Persian Gulf, and elsewhere. This article discusses public opinion concerning START II, the cost of its implementation, and the general purpose of the treaty.

  13. Telemetry Tests Of The Advanced Receiver II

    NASA Technical Reports Server (NTRS)

    Hinedi, Sami M.; Bevan, Roland P.; Marina, Miguel

    1993-01-01

    Report describes telemetry tests of Advanced Receiver II (ARX-II): digital radio receiving subsystem operating on intermediate-frequency output of another receiving subsystem called "multimission receiver" (MMR), detecting carrier, subcarrier, and data-symbol signals transmitted by spacecraft, and extracts Doppler information from signals. Analysis of data shows performance of MMR/ARX-II system comparable and sometimes superior to performances of Blk-III/BPA and Blk-III/SDA/SSA systems.

  14. AGEX II: Technical quarterly, Volume 2

    SciTech Connect

    Ekdahl, C.

    1995-03-01

    The AGEX II Technical Quarterly publishes short technical contributions on above ground experiments that use pulsed power and laser drivers. The Quarterly is intended to provide rapid exposure of timely technical ideas and results as well as a means for documenting AGEX II progress and scientific quality for the AGEX II community. Suitable topics include experimental results, diagnostic apparatus, theoretical design, and scaling, among others.

  15. SAGE II aerosol correlative observations - Profile measurements

    NASA Technical Reports Server (NTRS)

    Osborn, M. T.; Rosen, J. M.; Mccormick, M. P.; Wang, Pi-Huan; Livinfston, J. M.

    1989-01-01

    Profiles of the aerosol extinction measurements from the Stratospheric Aerosol and Gas Experiment (SAGE) II are compared with profiles from five correlative experiments between November 1984 and July 1986. The correlative profiles were derived from six-channel dustsonde measurements and two-wavelength lidar backscatter data. The correlation between the dustsonde- and lidar-derived measurements and the SAGE II data is good, validating the SAGE II lower stratospheric aerosol extinction measurements.

  16. Polymeric potassium triformatocobalt(II)

    PubMed Central

    Wöhlert, Susanne; Wriedt, Mario; Jess, Inke; Näther, Christian

    2011-01-01

    In the crystal structure of the title compound, poly[tri-μ-formato-cobalt(II)potassium], [CoK(CHO2)3]n the Co2+ cations are coordinated by six O-bonded formate anions in an octa­hedral coordination mode and the K+ cations are eightfold coordinated by seven O-bonded formate anions within irregular polyhedra. The Co2+ cations are connected by bridging formate anions into a three-dimensional coordination network in which the K+ cations are embedded. The asymmetric unit consits of one Co2+ cation located on a center of inversion, one K+ cation located on a twofold axis and two crystallographically independent formato anions, of which one is located on a twofold axis and the other occupies a general position. PMID:21753951

  17. PEP-II prototype klystron

    SciTech Connect

    Fowkes, W.R.; Caryotakis, G.; Lee, T.G.; Pearson, C.; Wright, E.L.

    1993-04-01

    A 540-kW continuous-wave (cw) klystron operating at 476 MHz was developed for use as a power source for testing PEP-II rf accelerating cavities and rf windows. It also serves as a prototype for a 1.2 MW cw klystron presently being developed as a potential rf source for asymmetric colliding ring use. The design incorporates the concepts and many of the parts used in the original 353 MHz PEP klystron developed sixteen years ago. The superior computer simulation codes available today result in improved performance with the cavity frequencies, drift lengths, and output circuit optimized for the higher frequency.The design and operating results of this tube are described with particular emphasis on the factors which affect efficiency and stability.

  18. Probing outflows in z = 1 ∼ 2 galaxies through Fe II/Fe II* multiplets

    SciTech Connect

    Tang, Yuping; Giavalisco, Mauro; Guo, Yicheng

    2014-10-01

    We report on a study of the 2300-2600 Å Fe II/Fe II* multiplets in the rest-UV spectra of star-forming galaxies at 1.0 < z < 2.6 as probes of galactic-scale outflows. We extracted a mass-limited sample of 97 galaxies at z ∼ 1.0-2.6 from ultra-deep spectra obtained during the GMASS spectroscopic survey in the GOODS South field with the Very Large Telescope and FORS2. We obtain robust measures of the rest equivalent width of the Fe II absorption lines down to a limit of W{sub r} > 1.5 Å and of the Fe II* emission lines to W{sub r} > 0.5 Å. Whenever we can measure the systemic redshift of the galaxies from the [O II] emission line, we find that both the Fe II and Mg II absorption lines are blueshifted, indicating that both species trace gaseous outflows. We also find, however, that the Fe II gas has generally lower outflow velocity relative to that of Mg II. We investigate the variation of Fe II line profiles as a function of the radiative transfer properties of the lines, and find that transitions with higher oscillator strengths are more blueshifted in terms of both line centroids and line wings. We discuss the possibility that Fe II lines are suppressed by stellar absorptions. The lower velocities of the Fe II lines relative to the Mg II doublet, as well as the absence of spatially extended Fe II* emission in two-dimensional stacked spectra, suggest that most clouds responsible for Fe II absorption lie close (3 ∼ 4 kpc) to the disks of galaxies. We show that the Fe II/Fe II* multiplets offer unique probes of the kinematic structure of galactic outflows.

  19. Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient patients.

    PubMed Central

    Sato, S; Zhu, X L; Sly, W S

    1990-01-01

    Carbonic anhydrase II (CA II) deficiency has been shown to be the primary defect in the recessively inherited syndrome of osteopetrosis with renal tubular acidosis. Until now, the absence of CA II in kidney of CA II-deficient patients has not been shown directly, and the status of the membrane-associated CA in kidney of CA II-deficient patients has been unclear. To address these questions, we analyzed urinary membranes and soluble fractions from normal and CA II-deficient subjects. The CA activity in membrane fractions of normal urine was found to comprise two components--(i) a vesicle-enclosed, sodium dodecyl sulfate (SDS)-sensitive fraction, which was shown immunochemically to be the 29-kDa CA II, and (ii) an SDS-resistant fraction, which was due to native and cleaved forms of the 35-kDa, membrane-anchored isozyme CA IV. Urinary membranes from CA II-deficient patients showed little or no SDS-sensitive activity and no immunoreactivity for CA II, providing direct evidence that their mutation, which produces CA II deficiency in erythrocytes, also affects CA II in kidney. CA IV activity and immunoreactivity were present in normal amounts in urinary membranes from CA II-deficient patients. We conclude from the enzymatic and immunological evidence presented that both CA II and CA IV are present in urinary membranes from normal subjects, that renal CA IV is present but renal CA II is absent in urinary membranes from patients with the CA II-deficiency syndrome, and that the methods presented should be useful in studying renal CA II and renal CA IV in other disorders of impaired bicarbonate reabsorption. Images PMID:2117271

  20. RNA polymerase II transcription: structure and mechanism.

    PubMed

    Liu, Xin; Bushnell, David A; Kornberg, Roger D

    2013-01-01

    A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five general transcription factors (GTFs) TFIIB, -D, -E, -F, and -H. The addition of Mediator enables a response to regulatory factors. The GTFs are required for promoter recognition and the initiation of transcription. Following initiation, pol II alone is capable of RNA transcript elongation and of proofreading. Structural studies reviewed here reveal roles of GTFs in the initiation process and shed light on the transcription elongation mechanism. This article is part of a Special Issue entitled: RNA Polymerase II Transcript Elongation.

  1. Antibacterial cobalt (II), copper (II), nickel (II) and zinc (II) complexes of mercaptothiadiazole--derived furanyl, thienyl, pyrrolyl, salicylyl and pyridinyl Schiff bases.

    PubMed

    Chohan, Zahid H; Pervez, Humayun; Rauf, Abdul; Khan, Khalid M; Supuran, Claudiu T

    2006-04-01

    A series of Co (II), Cu (II), Ni (II) and Zn (II) complexes of mercaptothiadiazole-derived furanyl, thienyl, pyrrorlyl, salicylyl and pyridinyl Schiff bases were synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella fexneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureous bacterial strains. The results of these studies show the metal complexes to be more antibacterial as compared to the prepared un-complexed Schiff bases.

  2. Spectroscopic and fluorescence studies on Mn(II), Co(II), Ni(II) and Cu(II) complexes with NO donor fluorescence dyes

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; El-Metwaly, Nashwa M.

    2011-10-01

    The reactions of the two common dyes [2TMPACT and 4PENI] with Mn(II), Co(II), Ni(II) and Cu(II) ions were done. All the isolated complexes have been characterized by physicochemical and spectroscopic techniques. The IR data reflect the bidentate mode of 2TMPACT towards the mononuclear complex [Mn(II)] even its tetradentate in binuclear complexes [Co(II) and Cu(II)]. However, the bidentate mode is the only behavior of 4PENI ligand towards each metal ion in its mononuclear complexes. The UV-vis spectral analysis beside the magnetic moment measurements are proposed different geometries concerning each metal ions with the two ligands under investigation, as the Mn(II)-2TMPACT complex is an octahedral but Mn(II)-4PENI is a tetrahedral geometry. All the synthesized compounds are thermogravimetrically investigated. The proposed thermal decomposition was discussed for each compound with each step as well as, the kinetic parameters were calculated for all preferrible decomposition steps. The mass spectroscopy tool was used to emphasis on the suitable molecular formula proposed and the fragmentation patterns were displayed. The fluorescence properties of the synthesized ligands and their complexes were studied in DMSO at room temperature.

  3. Spectroscopic and fluorescence studies on Mn(II), Co(II), Ni(II) and Cu(II) complexes with NO donor fluorescence dyes.

    PubMed

    Refat, Moamen S; el-Metwaly, Nashwa M

    2011-10-15

    The reactions of the two common dyes [2TMPACT and 4PENI] with Mn(II), Co(II), Ni(II) and Cu(II) ions were done. All the isolated complexes have been characterized by physicochemical and spectroscopic techniques. The IR data reflect the bidentate mode of 2TMPACT towards the mononuclear complex [Mn(II)] even its tetradentate in binuclear complexes [Co(II) and Cu(II)]. However, the bidentate mode is the only behavior of 4PENI ligand towards each metal ion in its mononuclear complexes. The UV-vis spectral analysis beside the magnetic moment measurements are proposed different geometries concerning each metal ions with the two ligands under investigation, as the Mn(II)-2TMPACT complex is an octahedral but Mn(II)-4PENI is a tetrahedral geometry. All the synthesized compounds are thermogravimetrically investigated. The proposed thermal decomposition was discussed for each compound with each step as well as, the kinetic parameters were calculated for all preferrible decomposition steps. The mass spectroscopy tool was used to emphasis on the suitable molecular formula proposed and the fragmentation patterns were displayed. The fluorescence properties of the synthesized ligands and their complexes were studied in DMSO at room temperature.

  4. Optimization of simultaneous electrochemical determination of Cd(II), Pb(II), Cu(II) and Hg(II) at carbon nanotube-modified graphite electrodes.

    PubMed

    Pikna, L'ubomír; Heželová, Mária; Kováčová, Zuzana

    2015-01-01

    The health of the environment is worsening every day. Monitoring of potentially toxic elements and remediation of environmental pollution are necessary. Therefore, the research and development of simple, inexpensive, portable and effective sensors is important. Electrochemistry is a useful component of the field of environment monitoring. The present study focuses on evaluating and comparing three types of electrodes (PIGE, PIGE/MWCNT/HNO3 and PIGE/MWCNT/EDTA/HNO3) employed for the simultaneous electrochemical determination of four potentially toxic elements: Cd(II), Pb(II), Cu(II) and Hg(II). Cyclic voltammograms were measured in an acetate buffer. The LOD, LOQ, the standard and relative precisions of the method and a prediction intervals were calculated (according to the technical procedure DIN 32 645) for the three electrodes and for each measured element. The LOD for PIGE/CNT/HNO3 (the electrode with narrowest calculated prediction intervals) was 2.98 × 10(-7) mol L(-1) for Cd(II), 4.83 × 10(-7) mol L(-1) for Pb(II), 3.81 × 10(-7) mol L(-1) for Cu(II), 6.79 × 10(-7) mol L(-1) for Hg(II). One of the benefits of this study was the determination of the amount of Hg(II) in the mixture of other elements.

  5. A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents.

    PubMed

    Diaz, Jorge R A; Fernández Baldo, Martín; Echeverría, Gustavo; Baldoni, Héctor; Vullo, Daniela; Soria, Delia B; Supuran, Claudiu T; Camí, Gerardo E

    2016-01-01

    A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, (1)H, and (13)C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P21/c space group. Antifungal activity was screened against eight pathogenic yeasts: Candida albicans (DMic 972576), Candida krusei (DMic 951705), Candida glabrata (DMic 982882), Candida tropicalis (DMic 982884), Candida dubliniensis (DMic 93695), Candida guilliermondii (DMic 021150), Cryptococcus neoformans (ATCC 24067), and Cryptococcus gattii (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported.

  6. Kinetics of Formation of Cobalt(II)- and Nickel(II) Carbonic Anhydrase.

    ERIC Educational Resources Information Center

    McQuate, Robert S.; Reardon, John E.

    1978-01-01

    Discusses the kinetic behavior associated with the interaction of metal ions with apocarbonic anhydrase, focusing on the formation of two metallocarbonic anhydrase--the biochemically active Co(II) and the inactive Ni(II)derivatives. (GA)

  7. ACCURATE RITZ WAVELENGTHS OF PARITY-FORBIDDEN [Co II] AND [V II] LINES OF ASTROPHYSICAL INTEREST

    SciTech Connect

    Ruffoni, M. P.; Pickering, J. C.

    2013-08-15

    We report a comprehensive list of accurate Ritz wavelengths for parity-forbidden [Co II] and [V II] lines obtained from the analysis of energy levels measured in the laboratory with Fourier transform emission spectroscopy. Such lines, particularly those in the infrared, are in demand for the analysis of low-density astrophysical plasmas in and around objects such as planetary nebulae, star-forming regions, and active galactic nuclei. Transitions between all known metastable levels of Co II and V II are included in our analysis, producing wavelengths for 1477 [V II] lines and 782 [Co II] lines. Of these, 170 [V II] lines and 171 [Co II] lines arise from transitions with calculated transition probabilities greater than 1 Multiplication-Sign 10{sup -2} s{sup -1} and upper level excitations of less than 5 eV, and thus are likely to be observed in astrophysical spectra.

  8. Heteroleptic bis(dipyrrinato)copper(II) and nickel(II) complexes.

    PubMed

    Toyoda, Ryojun; Tsuchiya, Mizuho; Sakamoto, Ryota; Matsuoka, Ryota; Wu, Kuo-Hui; Hattori, Yohei; Nishihara, Hiroshi

    2015-09-14

    Heteroleptic bis(dipyrrinato)copper(II) and nickel(II) complexes are synthesized. Their structures are determined by X-ray diffraction analysis, and their properties are investigated by using cyclic voltammetry, chronocoulometry, and UV/vis absorption spectroscopy.

  9. Voltammetric analysis of Cu (II), Cd (II) and Zn (II) complexes and their cyclic voltammetry with several cephalosporin antibiotics.

    PubMed

    Abo El-Maali, N; Osman, A H; Aly, A A M; Al-Hazmi, G A A

    2005-02-01

    Both osteryoung square wave voltammetry and cyclic voltammetry have been utilized to elucidate and confirm the possible complexation reaction that occur between the various cephalosporin antibiotics and either the toxic, non-essential metal ion, viz. Cd (II), or the essential but toxic (when their concentration exceeds certain level in serum) metal ions, viz. Cu (II) and Zn (II). Voltammetric measurements indicated the existence of 1:1 metal-to-ligand ratio (as in cephalexin and cephapirin complexes), 1:2 ratio (such as in cefamandole, cefuroxime and cefotaxime complexes) and 2:1 ratio in case of ceftazidime complexes. Adsorption behavior was evidenced for Cu (II)-cefuroxime or ceftazidime complexes as well as for those for Zn (II)-cephalexin or cephapirin. This phenomenon could be used for the determination of either the antibiotic or the metal ion using adsorptive stripping voltammetry. Detection limits down to 7x10(-10) M have been easily achieved.

  10. Adsorption of Cd(II) and Pb(II) from aqueous solutions on activated alumina.

    PubMed

    Naiya, Tarun Kumar; Bhattacharya, Ashim Kumar; Das, Sudip Kumar

    2009-05-01

    The ability of activated alumina as synthetic adsorbent was investigated for adsorptive removal of Cd(II) and Pb(II) ions from aqueous solutions. Various physico-chemical parameters such as pH, initial metal ion concentration, and adsorbent dosage level and equilibrium contact time were studied. The optimum solution pH for adsorption of Cd(II) and Pb(II) from aqueous solutions was found to be 5. Kinetics data were best described by pseudo-second order model. The effective particle diffusion coefficient of Cd(II) and Pb(II) are of the order of 10(-10) m(2)/s. Values of mass transfer coefficient were estimated as 4.868x10(-6) cm/s and 6.85x10(-6) cm/s for Cd(II) and Pb(II) adsorption respectively. The equilibrium adsorption data for Cd(II) and Pb(II) were better fitted to Langmuir adsorption isotherm model. The thermodynamic studies indicated that the adsorption was spontaneous and exothermic for Cd(II) adsorption and endothermic for Pb(II). The sorption energy calculated from Dubinin-Radushkevich isotherm were 11.85 kJ/mol and 11.8 kJ/mol for the adsorption of Cd(II) and Pb(II) respectively which indicated that both the adsorption processes were chemical in nature. Desorption studies were carried out using dilute mineral acids. Application studies carried out using industrial waste water samples containing Cd(II) and Pb(II) showed the suitability of activated alumina in waste water treatment plant operation.

  11. 40 CFR Table II-2 to Subpart II - Collection Efficiencies of Anaerobic Processes

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Collection Efficiencies of Anaerobic Processes II Table II-2 to Subpart II Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt....

  12. 40 CFR Table II-2 to Subpart II - Collection Efficiencies of Anaerobic Processes

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Collection Efficiencies of Anaerobic Processes II Table II-2 to Subpart II Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt....

  13. Sorption hysteresis of Cd(II) and Pb(II) on natural zeolite and bentonite.

    PubMed

    Hamidpour, Mohsen; Kalbasi, Mahmoud; Afyuni, Majid; Shariatmadari, Hossein; Holm, Peter E; Hansen, Hans Christian Brunn

    2010-09-15

    Sorption hysteresis in natural sorbents has important environmental implications for pollutant transport and bioavailability. We examined sorption reversibility of Cd(II) and Pb(II) on zeolite and bentonite. Sorption isotherms were derived by sorption of Cd(II) and Pb(II) from solutions containing a range of the metal concentrations corresponding to 10-100% maximum sorption capacity (SCmax) of the sorbents. The desorption experiments were performed immediately following the completion of sorption experiments. Sorption and desorption isotherms of Cd(II) and Pb(II) were well described by the Freundlich model. The results revealed that the desorption isotherms of Cd(II) and Pb(II) from zeolite significantly deviated from the sorption isotherms indicating irreversible or very slowly reversible sorption. For bentonite sorption/desorption isotherms were similar indicating reversible sorption. The extent of hysteresis was evaluated from sorption and desorption Freundlich parameters (K(f) and n) through the apparent hysteresis index (HI = n(desorb)/n(sorb); n is the exponent in the Freundlich equation) and differences in Freundlich K(f) parameters. Higher sorption irreversibility was obtained for Pb(II) as compared to Cd(II). The amounts of Cd(II) and Pb(II) desorbed from bentonite were more than from zeolite, indicating that zeolite was a more effective sorbent for water and wastewater treatment.

  14. Calix[4]arene based chemosensor for selective complexation of Cd(II) and Cu(II)

    NASA Astrophysics Data System (ADS)

    Qazi, Mansoor Ahmed; Qureshi, Imdadullah; Memon, Shahabuddin

    2010-06-01

    The present article describes synthesis, characterization and a detailed complexation study of calix[4]arene based chemosensor ( 4) bearing two anthracenyl units as signaling groups on its coordination sphere. The complex formation ability of 4 toward selected transition metals such as Cd(II), Co(II), Cu(II), Ni(II) and Pb(II) has been investigated by UV-visible spectroscopy. Assessment of results reveal that the chemosensor is selective toward Cd(II) and Cu(II). The FT-IR spectroscopic method was applied for further confirmation of the complexation phenomenon. Besides this, a study regarding interference of other metals on complex formation in solution has also supported the efficient binding preference of 4 for Cd(II) and Cu(II). From the results it has been concluded that 4 has compatible coordination sphere to accommodate these metals. The similarities and differences revealed that being soft nature of both metals and because of diagonal relationship in the periodic table their coordination behavior toward N/O-donor ligand may be treated as a test on possibility of the Cu(II) ions to be displaced by Cd(II). The study certainly will help in understanding the hazards of Cd(II) in biological systems.

  15. Diet History Questionnaire II & Canadian Diet History Questionnaire II: Web-based DHQ

    Cancer.gov

    The Web-based versions of DHQ II and C-DHQ II are identical in content to the paper forms. By automating the DHQ II and providing versions on the Web for public use, researchers have another tool to collect and analyze food frequency questionnaire data.

  16. Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b.

    PubMed

    Choi, Dong W; Do, Young S; Zea, Corbin J; McEllistrem, Marcus T; Lee, Sung-W; Semrau, Jeremy D; Pohl, Nicola L; Kisting, Clint J; Scardino, Lori L; Hartsel, Scott C; Boyd, Eric S; Geesey, Gill G; Riedel, Theran P; Shafe, Peter H; Kranski, Kim A; Tritsch, John R; Antholine, William E; DiSpirito, Alan A

    2006-12-01

    Methanobactin (mb) is a novel chromopeptide that appears to function as the extracellular component of a copper acquisition system in methanotrophic bacteria. To examine this potential physiological role, and to distinguish it from iron binding siderophores, the spectral (UV-visible absorption, circular dichroism, fluorescence, and X-ray photoelectron) and thermodynamic properties of metal binding by mb were examined. In the absence of Cu(II) or Cu(I), mb will bind Ag(I), Au(III), Co(II), Cd(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(VI), or Zn(II), but not Ba(II), Ca(II), La(II), Mg(II), and Sr(II). The results suggest metals such as Ag(I), Au(III), Hg(II), Pb(II) and possibly U(VI) are bound by a mechanism similar to Cu, whereas the coordination of Co(II), Cd(II), Fe(III), Mn(II), Ni(II) and Zn(II) by mb differs from Cu(II). Consistent with its role as a copper-binding compound or chalkophore, the binding constants of all the metals examined were less than those observed with Cu(II) and copper displaced other metals except Ag(I) and Au(III) bound to mb. However, the binding of different metals by mb suggests that methanotrophic activity also may play a role in either the solubilization or immobilization of many metals in situ.

  17. FOREWORD: HELAS II International Conference

    NASA Astrophysics Data System (ADS)

    Gizon, Laurent; Roth, Markus

    2008-07-01

    Volume 118 (2008) of Journal of Physics: Conference Series provides a written record of the talks and posters presented at the HELAS II International Conference `Helioseismology, Asteroseismology and MHD Connections'. The conference was held during the week 20-24 August 2007 in Göttingen, Germany, jointly hosted by the Max Planck Institute for Solar System Research and the Faculty of Physics of the University of Göttingen. A total of 140 scientists from all over the world attended. The Scientific Organizing Committee consisted of Conny Aerts, Annie Baglin, Jørgen Christensen-Dalsgaard, Thierry Corbard, Jadwiga Daszyńska-Daszkiewicz, Stefan Dreizler, Yvonne Elsworth, Laurent Gizon (Chairman), Wolfgang Glatzel, Frank Hill, Donald Kurtz, Oskar von der Lühe, Maria Pia Di Mauro, Mário Monteiro, Pere Pallé, Markus Roth, Philip Scherrer, Manfred Schüssler, and Michael Thompson. HELAS stands for the European Helio- and Asteroseismology Network, a Coordination Action supported by the sixth Framework Programme of the European Union. It aims to bring together researchers in the fields of solar and stellar oscillations. This volume consists of 91 articles organized into sections that reflect the scientific programme of the conference: 012001-07 Wave diagnostics in physics, geophysics and astrophysics 012008-09 Perspectives on helio- and asteroseismology 012010-17 Asteroseismology: Observations 012018-25 Asteroseismology: Theory 012026-32 Global helioseismology and solar models 012033-38 Local helioseismology and magnetic activity 012039-44 Future observational projects in helio- and asteroseismology 012045-91 Poster papers. The overwhelming majority of papers discuss the seismology of the Sun and stars. Papers in the first section provide a broader perspective on wave phenomena and techniques for probing other physical systems, from living beings to the universe as a whole. We were extremely fortunate to have particularly distinguished experts to cover these topics

  18. Moderately luminous Type II supernovae

    NASA Astrophysics Data System (ADS)

    Inserra, C.; Pastorello, A.; Turatto, M.; Pumo, M. L.; Benetti, S.; Cappellaro, E.; Botticella, M. T.; Bufano, F.; Elias-Rosa, N.; Harutyunyan, A.; Taubenberger, S.; Valenti, S.; Zampieri, L.

    2013-07-01

    Context. Core-collapse Supernovae (CC-SNe) descend from progenitors more massive than about 8 M⊙. Because of the young age of the progenitors, the ejecta may eventually interact with the circumstellar medium (CSM) via highly energetic processes detectable in the radio, X-ray, ultraviolet (UV) and, sometimes, in the optical domains. Aims: In this paper we present ultraviolet, optical and near infrared observations of five Type II SNe, namely SNe 2009dd, 2007pk, 2010aj, 1995ad, and 1996W. Together with few other SNe they form a group of moderately luminous Type II events. We investigate the photometric similarities and differences among these bright objects. We also attempt to characterise them by analysing the spectral evolutions, in order to find some traces of CSM-ejecta interaction. Methods: We collected photometry and spectroscopy with several telescopes in order to construct well-sampled light curves and spectral evolutions from the photospheric to the nebular phases. Both photometry and spectroscopy indicate a degree of heterogeneity in this sample. Modelling the data of SNe 2009dd, 2010aj and 1995ad allows us to constrain the explosion parameters and the properties of the progenitor stars. Results: The light curves have luminous peak magnitudes (-16.95 < MB < -18.70). The ejected masses of 56Ni for three SNe span a wide range of values (2.8 × 10-2 M⊙ < M(56Ni)< 1.4 × 10-1 M⊙), while for a fourth (SN 2010aj) we could determine a stringent upper limit (7 × 10-3 M⊙). Clues of interaction, such as the presence of high velocity (HV) features of the Balmer lines, are visible in the photospheric spectra of SNe 2009dd and 1996W. For SN 2007pk we observe a spectral transition from a Type IIn to a standard Type II SN. Modelling the observations of SNe 2009dd, 2010aj and 1995ad with radiation hydrodynamics codes, we infer kinetic plus thermal energies of about 0.2-0.5 foe, initial radii of 2-5 × 1013 cm and ejected masses of ~5.0-9.5 M⊙. Conclusions: These

  19. Construction of Escherichia coli Strains for Conversion of Nitroacetophenones to ortho-Aminophenols

    DTIC Science & Technology

    2003-11-01

    spinning, and fiber mechanical properties of poly(p-phenylenebenzoxazole). Macromolecules 14:920–924. 5. Dalgliesh, C. E. 1955. Excretion of conjugated...step synthesis of high temperature 6F- polybenzoxazoles . Polymer Prepr. 31:675– 676. 8. Escobar, C. A., M. Kluge, and D. Sicker. 1997. Biomimetic... polybenzoxazoles . J. Polym. Sci. 3:2107–2121. 24. Murata, H., H. Ushio, and H. Furutani. September 1996. Crystalline 3-ami- no-2-hydroxyacetophenone salt

  20. Adsorption of Cd(II), Cu(II) and Ni(II) ions by cross-linking chitosan/rectorite nano-hybrid composite microspheres.

    PubMed

    Zeng, Lixuan; Chen, Yufei; Zhang, Qiuyun; Guo, Xingmei; Peng, Yanni; Xiao, Huijuan; Chen, Xiaocheng; Luo, Jiwen

    2015-10-05

    Chitosan/rectorie (CTS/REC) nano-hybrid composite microsphere was prepared by changing the proportion of CTS/REC with 2:1, 3:1 and 4:1. Compared with the pure cross-linking chitosan microsphere, the nano-hybrid composite microsphere was proved to have better sorption capacity of Cd(II), Cu(II) and Ni(II), especially 2:1(CTS/REC-1). The adsorption behavior of the microsphere of Cd(II), Cu(II) and Ni(II) was investigated in single and binary metal systems. In single system, the equilibrium studies showed that the adsorption of Cd(II), Cu(II) and Ni(II) followed the Langmuir model and the pseudo-second-order kinetic model. The negative values of (ΔG) suggested that the adsorption process was spontaneous. In binary system, the combined action of the metals was found to be antagonistic and the metal sorption followed the order of Cu(II)>Cd(II)>Ni(II). The regeneration studies indicated that EDTA desorbed Cd(II), Cu(II) and Ni(II) from cross-linking microspheres better than HCl. The FT-IR and XPS spectra showed that coordination bonds were formed between Cd(II), Cu(II) and Ni(II) and the nitrogen atoms of cross-linking CTS/REC nano-hybrid composite microspheres.

  1. World War II Homefront: A Historiography.

    ERIC Educational Resources Information Center

    Winkler, Allan M.

    2002-01-01

    Highlights the scholarship that exists on the World War II homefront covering topics such as World War II as a good war, Franklin D. Roosevelt, economic policy, propaganda, status of women and women's employment, the role of African Americans, racial violence, and the Japanese American experience. (CMK)

  2. Addressing Instructional Avoidance with Tier II Supports

    ERIC Educational Resources Information Center

    Anderson, Cynthia M.; Turtura, Jessica; Parry, Michael

    2013-01-01

    In a 3-tiered, prevention-oriented framework, Tier II (secondary, targeted) interventions are designed for students whose problem behaviors have not responded to Tier I but are not severe enough to warrant an individualized Tier III intervention. Tier II interventions are implemented similarly across students receiving the intervention and can be…

  3. The CNET Automated Budget System (CABS) II.

    ERIC Educational Resources Information Center

    Middleton, Morris G.; And Others

    The Chief of Naval Education and Training (CNET) Automated Budget System II (CABS II) is an improved and expanded version of an earlier system which was developed by the Training Analysis and Evaluation Group (TAEG) to provide an efficient, easy means of handling the large volume of data necessary to produce budget documents. Intended as a guide…

  4. Children Teaching Children II. [CD-ROM].

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Office of School Improvement.

    Children Teaching Children (CTC): Collection II is a CD-ROM created at 6 elementary schools in the West Contra Costa Unified School District (California) as part of the Coaching Odyssey for school improvement. CTC II, published by the California Department of Education, is an effective early literacy intervention that integrates the development of…

  5. World War II: A Technology Lesson Plan.

    ERIC Educational Resources Information Center

    Hagar, Suzy

    1990-01-01

    Presents a class activity on the history, causes, and consequences of World War II. Focuses on the development and deployment of the atomic bomb. Utilizes a Video Encyclopedia Program for historical background. Divides the class into groups that are responsible for researching and preparing a videotape on a World War II topic. (RW)

  6. Geology of the Phase II System

    SciTech Connect

    Laney, R.; Laughlin, A. William

    1980-11-19

    This is a report on the analysis of EE-2 cuttings and thin sections, geologic characterization of the Phase II system, comparison with Phase 1, and geologic speculations and recommendations concerning Phase II. The EE-2 litholog has been included in the pocket.

  7. World War II Memorial Learning Activities.

    ERIC Educational Resources Information Center

    Tennessee State Dept. of Education, Nashville.

    These learning activities can help students get the most out of a visit to the Tennessee World War II Memorial, a group of ten pylons located in Nashville (Tennessee). Each pylon contains informational text about the events of World War II. The ten pylons are listed as: (1) "Pylon E-1--Terror: America Enters the War against Fascism, June…

  8. Fits, pyridoxine, and hyperprolinaemia type II.

    PubMed

    Walker, V; Mills, G A; Peters, S A; Merton, W L

    2000-03-01

    The rare inherited disorder hyperprolinaemia type II presents with fits in childhood, usually precipitated by infection. A diagnosis of hyperprolinaemia type II and vitamin B(6) deficiency was made in a well nourished child with fits. It is thought that pyridoxine deficiency was implicated in her fits and was the result of inactivation of the vitamin by the proline metabolite, pyrroline-5-carboxylate.

  9. Hearing Restoration in Neurofibromatosis Type II Patients

    PubMed Central

    Lee, Jeon Mi; Chang, Jin Woo; Choi, Jae Young

    2016-01-01

    Patients with neurofibromatosis type II will eventually succumb to bilateral deafness. For patients with hearing loss, modern medical science technology can provide efficient hearing restoration through a number of various methods. In this article, several hearing restoration methods for patients with neurofibromatosis type II are introduced. PMID:27189272

  10. TRUPACT-II procedures and maintenance instructions

    SciTech Connect

    1994-01-14

    The purpose of this document is to provide the technical requirements for operation, inspection and maintenance of a TRUPACT-II Shipping Package and directly related components. This document shall supply the minimum requirements as specified in the TRUPACT-II Safety Analysis Report for Packaging (SARP) and Certificate of Compliance (C of C) 9218. In the event there is a conflict between this document and the TRUPACT-II SARP (NRC Certificate of Compliance No. 9218), the TRUPACT-II SARP shall govern. This document details the operations, maintenance, repair, replacement of components, as well as the documentation required and the procedures to be followed to maintain the integrity of the TRUPACT-II container. These procedures may be modified for site use, but as a minimum all parameters and format listed herein must be included in any site modified version. For convenience and where applicable steps may be performed out of sequence. Packaging and payload handling equipment and transport trailers have been specifically designed for use with the TRUPACT-II Packaging. This document discusses the minimum required procedures for use of the adjustable center of gravity lift fixture and the TRUPACT-II transport trailer in conjunction with the TRUPACT-II Packaging.

  11. Biology II Curriculum Guide. Bulletin 1820.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Div. of Academic Programs.

    In 1986, the Louisiana State Board of Elementary and Secondary Education requested that an advanced course in Biology II be developed. The resulting curriculum guide contains grade appropriate goals, skills, and competencies; suggested activities; suggested materials of instruction; and minimum time allotments for instruction. Biology II is a…

  12. Run II data analysis on the grid

    SciTech Connect

    Igor Mandrichenko, Igor Terekhov and Frank Wurthwein

    2002-12-02

    In this document, we begin the technical design for the distributed RunII computing for CDF and D0. The present paper defines the three components of the data handling area of Run II computing, namely the Data Handling System, the Storage System and the Application. We outline their functionality and interaction between them. We identify necessary and desirable elements of the interfaces.

  13. Synthesis, DFT Calculation, and Antimicrobial Studies of Novel Zn(II), Co(II), Cu(II), and Mn(II) Heteroleptic Complexes Containing Benzoylacetone and Dithiocarbamate

    PubMed Central

    Ekennia, Anthony C.; Onwudiwe, Damian C.; Olasunkanmi, Lukman O.; Osowole, Aderoju A.; Ebenso, Eno E.

    2015-01-01

    Heteroleptic complexes of zinc(II), copper(II), manganese(II), and cobalt(II) of the types [MLL′(H2O)2]·nH2O and [MLL′]·nH2O have been synthesized using sodium N-methyl-N-phenyldithiocarbamate (L) and benzoylacetone (L′). The metal complexes were characterized by elemental analysis, electrical conductance, magnetic susceptibility, infrared (IR), and UV-visible spectroscopic studies. The electrical conductance measurements revealed the nonelectrolytic nature of the synthesized complexes. The results of the elemental analyses, magnetic susceptibility measurements, and electronic spectra inferred that the Zn(II) complex adopted a four-coordinate geometry while the Co(II), Cu(II), and Mn(II) complexes assumed octahedral geometries. The IR spectra showed that the metal ions coordinated with the ligands via the S- and O-donor atoms. The geometry, electronic, and thermodynamic parameters of the complexes were obtained from density functional theory (DFT) calculations. The spin density distributions, relative strength of H–bonds, and thermodynamic parameters revealed that the order of stability of the metal complexes is Mn < Co < Cu > Zn. The agar diffusion methods were used to study the antimicrobial activity of the complexes against two Gram positive bacteria (S. aureus and S. pneumoniae), one Gram negative bacterium (E. coli), and two fungi organisms (A. niger and A. candida) and the complexes showed a broad spectrum of activities against the microbes. PMID:26681931

  14. Micro Channel/Multibus-II Interface Circuit

    NASA Technical Reports Server (NTRS)

    D'Ambrose, John J.; Jaworski, Richard C.; Heise, Nyles N.; Thornton, David N.

    1991-01-01

    Micro Channel/Multibus-II interface circuit provides electrical interconnections enabling communications between Micro Channels of IBM Personal System/2 computers and IEEE 1296 standard Multibus-II parallel system bus (iPSB). Made mostly of commercially available parts, interface enables independent Micro Channels to communicate over iPSB without modification.

  15. Interpreting the H II Region Luminosity Function

    NASA Astrophysics Data System (ADS)

    Oey, M. S.; Clarke, C. J.

    1998-12-01

    We construct Monte Carlo simulations of the H II region luminosity function (H II LF), drawing ionizing stars from a constant stellar IMF, and the number of ionizing stars from a power-law distribution of constant slope. We find that observed variations in the form of the H II LF across the Hubble sequence can be explained by a trend in the maximum number of ionizing stars per nebula. In addition, variations in the form of the H II LF between arm and interarm populations of spiral galaxies can be explained by evolutionary effects. The H II LF can thus reveal features in the most recent (< 10 Myr) star formation history of the host galaxies.

  16. TRUPACT-II Operating and Maintenance Instructions

    SciTech Connect

    Westinghouse Electric Corporation, Waste Isolation Division

    1999-12-31

    The purpose of this document is to provide the technical requirements for preparation for use, operation, inspection, and maintenance of a Transuranic Package Transporter Model II (TRUPACT-II) Shipping Package and directly related components. This document complies with the minimum requirements as specified in the TRUPACT-II Safety Analysis Report for Packaging (SARP) and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9218. In the event there is a conflict between this document and the TRUPACT-II SARP, the TRUPACT-II SARP shall govern. TRUPACT-II C of C number 9218 states, ''... each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application.'' It further states, ''... each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the application.'' Chapter 9 of the TRUPACT-II SARP charges the Westinghouse Electric Corporation Waste Isolation Division (WID) with assuring that the TRUPACT-II is used in accordance with the requirements of the C of C. To meet this requirement and verify consistency of operations when loading and unloading the TRUPACT-II on the trailer, placing a payload in the packaging, unloading the payload from the packaging, or performing maintenance, the U.S. Department of Energy Carlsbad Area Office (U.S. DOE/CAO) finds it necessary to implement the changes that follow. This TRUPACT-II maintenance document represents a change to previous philosophy regarding site specific procedures for the use of the TRUPACT-II. This document details the instructions to be followed to consistently operate and maintain the TRUPACT-II. The intent of these instructions is to ensure that all users of the TRUPACT-II follow the same or equivalent instructions. Users may achieve this intent by any of the following methods: (1) Utilizing these instructions as is, or (2

  17. TRUPACT-II, a regulatory perspective

    SciTech Connect

    Gregory, P.C.; Spooner, O.R.

    1995-12-31

    The Transuranic Package Transporter II (TRUPACT-II) is a US Nuclear Regulatory Commission (NRC) certified Type B packaging for the shipment of contact-handled transuranic (CH-TRU) material by the US Department of Energy (DOE). The NRC approved the TRUPACT-II design as meeting the requirements of Title 10, Code of Federal Regulations, Part 71 (10 CFR 71) and issued Certificate of Compliance (CofC) Number 9218 to the DOE. There are currently 15 certified TRUPACT-IIs. Additional TRUPACT-IIs will be required to make more than 15,000 shipments of CH-TRU waste to the Waste Isolation Pilot Plant (WIPP) site near Carlsbad, New Mexico. The TRUPACT-II may also be used for the DOE inter-site and intra-site shipments of CH-TRU waste. The Land Withdrawal Act (Public Law 102-579), enacted by the US Congress, October 30, 1992, and an agreement between the DOE and the State of New Mexico, signed August 4, 1987, both stipulate that only NRC approved packaging may be used for shipments of TRU waste to the WIPP. Early in the TRUPACT-II development phase it was decided that the transportation system (tractor, trailer, and TRUPACT-II) should be highway legal on all routes without the need for oversize and/or overweight permits. In large measure, public acceptance of the DOE`s efforts to safely transport CH-TRU waste depends on the public`s perception that the TRUPACT-II is in compliance with all applicable regulations, standards, and quality assurance requirements. This paper addresses some of the numerous regulations applicable to Type B packaging, and it describes how the TRUPACT-II complies with these regulations.

  18. Ozone Conference II: Abstract Proceedings

    SciTech Connect

    1999-11-01

    Ozone Conference II: Pre- and Post-Harvest Applications Two Years After Gras, was held September 27-28, 1999 in Tulare, California. This conference, sponsored by EPRI's Agricultural Technology Alliance and Southern California Edison's AgTAC facility, was coordinated and organized by the on-site ATA-AgTAC Regional Center. Approximately 175 people attended the day-and-a-half conference at AgTAC. During the Conference twenty-two presentations were given on ozone food processing and agricultural applications. Included in the presentations were topics on: (1) Ozone fumigation; (2) Ozone generation techniques; (3) System and design applications; (4) Prewater treatment requirements; (5) Poultry water reuse; (6) Soil treatments with ozone gas; and (7) Post-harvest aqueous and gaseous ozone research results. A live videoconference between Tulare and Washington, D.C. was held to discuss the regulators' view from inside the beltway. Attendees participated in two Roundtable Question and Answer sessions and visited fifteen exhibits and demonstrations. The attendees included university and governmental researchers, regulators, consultants and industry experts, technology developers and providers, and corporate and individual end-users. This report is comprised of the Abstracts of each presentation, biographical sketches for each speaker and a registration/attendees list.

  19. II-VI widegap superlattices

    NASA Astrophysics Data System (ADS)

    Taguchi, T.; Yamada, Y.; Endoh, Y.; Nozue, Y.; Mullins, J. T.; Ohno, T.; Masumoto, Y.; Takeda, S.

    We review our recent results of the excitonic properties in ZnSeZnS and Cd xZn 1-xSZnS strained-layer superlattices (SLSs). The most important physical insights in the II-VI widegap superlattices are to understand the relationship between the optical properties of quasi-two-dimensional exciton and strain because the well layer frequently receives biaxial compression or tension. The strain thus causes the significant shifts of the bandgap and splitting of the valence band. Semi-quantative calculations lead to an expectation that ZnSeZnS SLS always exhibits a type I band lineup within 100 Å thicknesses of the ZnSe well at a constant ZnS barrier width of several tens angstrom. This is in good agreement with the experimental results of exciton absorption and its luminescence excitation spectra. The Cd 0.3Zn 0.7SZnS SLSs with a range of well widths can produce intense excitonic emissions around 3.4 eV at room temperature due to the quantum confinement of excitons in the ternary CdZnS well. In order to elucidate localisation and relaxation processes of excitons, we have for the first time reported a multiple-LO-phonon emission process in the excitation spectra. The electric-field studies suggest that the concomitant decrease in intensity and the energy downshift of the exciton line may originate from the quantum confined Stark effect.

  20. PEP-II operations report

    NASA Astrophysics Data System (ADS)

    Zisman, Michael S.

    2001-04-01

    PEP-II is a two-ring asymmetric B factory operating at the ϒ(4S) resonance. It was constructed by a SLAC-LBNL-LLNL collaboration. The collider comprises two rings, a High-Energy Ring (HER) storing 9 GeV electrons, and a Low-Energy Ring (LER) storing 3.1 GeV positrons. Commissioning of the HER began in mid-1997 and commissioning of the LER began in mid-1998. First evidence for collisions was obtained on July 23, 1998. The B AB AR detector was installed in early 1999, and commissioning with the detector commenced in May 1999. In the present run, which began in October 1999, the peak luminosity has reached 3.1×10 33 cm-2 s-1 and the integrated luminosity delivered is 25 fb-1. In this paper we describe the startup experience and summarize the operational experience during fiscal year 2000 (from October 1999 through September 2000). Plans for luminosity upgrades are briefly described.

  1. Early failure of Class II resin composite versus Class II amalgam restorations placed by dental students.

    PubMed

    Overton, J D; Sullivan, Diane J

    2012-03-01

    Using the information from remake request slips in a dental school's predoctoral clinic, we examined the short-term survival of Class II resin composite restorations versus Class II dental amalgam restorations. In the student clinic, resin composite is used in approximately 58 percent of Class II restorations placed, and dental amalgam is used in the remaining 42 percent. In the period examined, Class II resin composite restorations were ten times more likely to be replaced at no cost to the patient than Class II dental amalgam restorations. A total of eighty-four resin composite restorations and six amalgam restorations were replaced due to an identified failure.

  2. Synthesis and characterization of Co(II), Ni(II) and Cu(II) complexes involving hydroxy antipyrine azodyes

    NASA Astrophysics Data System (ADS)

    Gaber, M.; Hassanein, A. M.; Lotfalla, A. A.

    2008-03-01

    The complexes formed between some hydroxy antipyrine azodyes and Co(II), Ni(II) and Cu(II) ions were studied spectrophotometrically in solution. The stoichiometry and stability constants of the metal chelates were determined. The spectrophotometric determination of the titled metal ions and titration using EDTA were reported. The chelating behaviour of the azodyes was confirmed by preparing the solid chelates in which their structures are elucidated using molar conductance, elemental, thermogravimetric (TGA) analyses, IR, ESR and electronic spectra as well as the magnetic measurements. Kinetic parameters are computed from the thermal decomposition data. The electrical properties for the metal complexes are measured from which the activation energies are calculated.

  3. Adsorption of Cu(II), Hg(II), and Ni(II) ions by modified natural wool chelating fibers.

    PubMed

    Monier, M; Ayad, D M; Sarhan, A A

    2010-04-15

    The graft copolymerization of ethyl acrylate (EA) onto natural wool fibers initiated by potassium persulphate and Mohr's salt redox initiator system in limited aqueous medium was carried out in heterogeneous media. Ester groups of the grafted copolymers were partially converted into hydrazide function groups followed by hydrazone formation through reaction with isatin. Also the application of the modified fibers for metal ion uptake was studied using Cu(II), Hg(II) and Ni(II). The modified chelating fibers were characterized using FTIR spectroscopy, SEM and X-ray diffraction.

  4. Effects of Mg II and Ca II ionization on ab-initio solar chromosphere models

    NASA Technical Reports Server (NTRS)

    Rammacher, W.; Cuntz, M.

    1991-01-01

    Acoustically heated solar chromosphere models are computed considering radiation damping by (non-LTE) emission from H(-) and by Mg II and Ca II emission lines. The radiative transfer equations for the Mg II k and Ca II K emission lines are solved using the core-saturation method with complete redistribution. The Mg II k and Ca II K cooling rates are compared with the VAL model C. Several substantial improvements over the work of Ulmschneider et al. (1987) are included. It is found that the rapid temperature rises caused by the ionization of Mg II are not formed in the middle chromosphere, but occur at larger atmospheric heights. These models represent the temperature structure of the 'real' solar chromosphere much better. This result is a major precondition for the study of ab-initio models for solar flux tubes based on MHD wave propagation and also for ab-initio models for the solar transition layer.

  5. Solid-phase extraction of Mn(II), Co(II), Ni(II), Cu(II), Cd(II) and Pb(II) ions from environmental samples by flame atomic absorption spectrometry (FAAS).

    PubMed

    Duran, Celal; Gundogdu, Ali; Bulut, Volkan Numan; Soylak, Mustafa; Elci, Latif; Sentürk, Hasan Basri; Tüfekci, Mehmet

    2007-07-19

    A new method using a column packed with Amberlite XAD-2010 resin as a solid-phase extractant has been developed for the multi-element preconcentration of Mn(II), Co(II), Ni(II), Cu(II), Cd(II), and Pb(II) ions based on their complex formation with the sodium diethyldithiocarbamate (Na-DDTC) prior to flame atomic absorption spectrometric (FAAS) determinations. Metal complexes sorbed on the resin were eluted by 1 mol L(-1) HNO3 in acetone. Effects of the analytical conditions over the preconcentration yields of the metal ions, such as pH, quantity of Na-DDTC, eluent type, sample volume and flow rate, foreign ions etc. have been investigated. The limits of detection (LOD) of the analytes were found in the range 0.08-0.26 microg L(-1). The method was validated by analyzing three certified reference materials. The method has been applied for the determination of trace elements in some environmental samples.

  6. Chitosan film loaded with silver nanoparticles-sorbent for solid phase extraction of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II).

    PubMed

    Djerahov, Lubomir; Vasileva, Penka; Karadjova, Irina; Kurakalva, Rama Mohan; Aradhi, Keshav Krishna

    2016-08-20

    The present study describes the ecofriendly method for the preparation of chitosan film loaded with silver nanoparticles (CS-AgNPs) and application of this film as efficient sorbent for separation and enrichment of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II). The stable CS-AgNPs colloid was prepared by dispersing the AgNPs sol in chitosan solution at appropriate ratio and further used to obtain a cast film with very good stability under storage and good mechanical strength for easy handling in aqueous medium. The incorporation of AgNPs in the structure of CS film and interaction between the polymer matrix and nanoparticles were confirmed by UV-vis and FTIR spectroscopy. The homogeneously embedded AgNPs (average diameter 29nm, TEM analysis) were clearly observed throughout the film by SEM. The CS-AgNPs nanocomposite film shows high sorption activity toward trace metals under optimized chemical conditions. The results suggest that the CS-AgNPs nanocomposite film can be feasibly used as a novel sorbent material for solid-phase extraction of metal pollutants from surface waters.

  7. New Rh2(II,II) Architecture for the Catalytic Reduction of H⁺.

    PubMed

    White, Travis A; Witt, Suzanne E; Li, Zhanyong; Dunbar, Kim R; Turro, Claudia

    2015-10-19

    Formamidinate-bridged Rh2(II,II) complexes containing diimine ligands of the formula cis-[Rh2(II,II)(μ-DTolF)2(NN)2](2+) (Rh2-NN2), where DTolF = p-ditolylformamidinate and NN = dppn (benzo[i]dipyrido[3,2-a:2',3'-h]quinoxaline), dppz (dipyrido[3,2-a:2',3'-c]phenazine), and phen (1,10-phenanthroline), electrocatalytically reduce H(+) to H2 in DMF solutions containing CH3COOH at a glassy carbon electrode. Cathodic scans in the absence of acid display a Rh(III,II/II,II) reduction at -0.90 V vs Fc(+)/Fc followed by NN(0/-) reduction at -1.13, -1.36, and -1.65 V for Rh2-dppn2, Rh2-dppz2, and Rh2-phen2, respectively. Upon the addition of acid, Rh2-dppn2 and Rh2-dppz2 undergo reduction-protonation-reduction at each pyrazine-containing NN ligand prior to the Rh2(II,II/II,I) reduction. The Rh2(II,I) species is then protonated at one of the metal centers, resulting in the formation of the corresponding Rh2(II,III)-hydride. In the case of Rh2-phen2, the reduction of the phen ligand is followed by intramolecular electron transfer to the Rh2(II,II) core in the presence of protons to form a Rh2(II,III)-hydride species. Further reduction and protonation at the Rh2 core for all three complexes rapidly catalyzes H2 formation with varied calculated turnover frequencies (TOF) and overpotential values (η): 2.6 × 10(4) s(-1) and 0.56 V for Rh2-dppn, 2.8 × 10(4) s(-1) and 0.50 V for Rh2-dppz2, and 5.9 × 10(4) s(-1) and 0.64 V for Rh2-phen2. Bulk electrolysis confirmed H2 formation, and further CH3COOH addition regenerates H2 production, attesting to the robust nature of the architecture. The cis-[Rh2(II,II)(μ-DTolF)2(NN)2](2+) architecture benefits by combining electron-rich formamidinate bridges, a redox-active Rh2(II,II) core, and electron-accepting NN diimine ligands to allow for the electrocatalysis of H(+) substrate to H2 fuel.

  8. Inhibition of chymotrypsin by heparin cofactor II.

    PubMed Central

    Church, F C; Noyes, C M; Griffith, M J

    1985-01-01

    Human heparin cofactor II is a plasma protein that is known to inhibit thrombin. The rate of thrombin inhibition by heparin cofactor II is accelerated (greater than or equal to 1000-fold) in the presence of the glycosaminoglycans, heparin and dermatan sulfate. We have found that chymotrypsin A alpha is also inhibited by heparin cofactor II with a second-order rate constant value of 1.8 X 10(6) M-1 X min-1 at pH 8.0 and 25 degrees C. However, there was no measurable effect of heparin or dermatan sulfate on the rate of chymotrypsin inhibition. Arginine-modified heparin cofactor II showed a comparable percentage loss of both antichymotrypsin and antithrombin activities. Heparin cofactor II and chymotrypsin formed a stable complex with a Mr value near 90,000 when analyzed by NaDodSO4/polyacrylamide gel electrophoresis; this suggests a 1:1 reaction stoichiometry. The chymotrypsin cleavage site in heparin cofactor II was the same as that for thrombin, and primary structure analysis of the inhibitor showed a P'1-P'8 sequence of Ser-Thr-Gln-Val-Arg-Phe-Thr-Val ... . The results indicate that, in contrast to alpha 1-antichymotrypsin, which does not inhibit trypsin-like enzymes, including thrombin, heparin cofactor II can effectively inhibit both thrombin and chymotrypsin. PMID:3863104

  9. Dinuclear Metallacycles with Single M-X-M Bridges (X = Cl(-), Br(-); M = Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II)): Strong Antiferromagnetic Superexchange Interactions.

    PubMed

    Reger, Daniel L; Pascui, Andrea E; Foley, Elizabeth A; Smith, Mark D; Jezierska, Julia; Wojciechowska, Agnieszka; Stoian, Sebastian A; Ozarowski, Andrew

    2017-03-06

    A series of monochloride-bridged, dinuclear metallacycles of the general formula [M2(μ-Cl)(μ-L)2](ClO4)3 have been prepared using the third-generation, ditopic bis(pyrazolyl)methane ligands L = m-bis[bis(1-pyrazolyl)methyl]benzene (Lm), M = Cu(II), Zn(II), and L = m-bis[bis(3,5-dimethyl-1-pyrazolyl)methyl]benzene (Lm*), M = Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II). These complexes were synthesized from the direct reactions of M(ClO4)2·6H2O, MCl2, and the ligand, Lm or Lm*, in the appropriate stoichiometric amounts. Three analogous complexes of the formula [M2(μ-Cl)(μ-L)2](BF4)3, L = Lm, M = Cu(II), and L = Lm*, M = Co(II), Cu(II), were prepared from the reaction of [M2(μ-F)(μ-L)2](BF4)3 and (CH3)3SiCl. The bromide-bridged complex [Cu2(μ-Br)(μ-Lm*)2](ClO4)3 was prepared by the first method. Three acyclic complexes, [Co2(μ-Lm)μ-Cl4], [Co2(μ-Lm*)Cl4], and [Co2(μ-Lm*)Br4], were also prepared. The structures of all [M2(μ-X)(μ-L)2](3+) (X = Cl(-), Br(-)) complexes have two ditopic bis(pyrazolyl)methane ligands bridging two metals in a metallacyclic arrangement. The fifth coordination site of the distorted trigonal bipyramidal metal centers is filled by a bridging halide ligand that has an unusual linear or nearly linear M-X-M angle. The NMR spectra of [Zn2(μ-Cl)(μ-Lm*)2](ClO4)3 and especially [Cd2(μ-Cl)(μ-Lm*)2](ClO4)3 demonstrate that the metallacycle structure is maintained in solution. Solid state magnetic susceptibility data for the copper(II) compounds show very strong antiferromagnetic exchange interactions, with -J values of 536 cm(-1) for [Cu2(μ-Cl)(μ-Lm)2](ClO4)3·xCH3CN, 720 cm(-1) for [Cu2(μ-Cl)(μ-Lm*)2](ClO4)3, and 945 cm(-1) for [Cu2(μ-Br)(μ-Lm*)2](ClO4)3·2CH3CN. Smaller but still substantial antiferromagnetic interactions are observed with other first row transition metals, with -J values of 98 cm(-1) for [Ni2(μ-Cl)(μ-Lm*)2](ClO4)3, 55 cm(-1) for [Co2(μ-Cl)(μ-Lm*)2](ClO4)3, and 34 cm(-1) for [Fe2(μ-Cl)(μ-Lm*)2](ClO4

  10. Angiotensin II receptors in testes

    SciTech Connect

    Millan, M.A.; Aguilera, G.

    1988-05-01

    Receptors for angiotensin II (AII) were identified and characterized in testes of rats and several primate species. Autoradiographic analysis of the binding of 125I-labeled (Sar1,Ile8)AII to rat, rhesus monkey, cebus monkey, and human testicular slide-mounted frozen sections indicated specific binding to Leydig cells in the interstitium. In rat collagenase-dispersed interstitial cells fractionated by Percoll gradient, AII receptor content was parallel to that of hCG receptors, confirming that the AII receptors are in the Leydig cells. In rat dispersed Leydig cells, binding was specific for AII and its analogs and of high affinity (Kd, 4.8 nM), with a receptor concentration of 15 fmol/10(6) cells. Studies of AII receptors in rat testes during development reveals the presence of high receptor density in newborn rats which decreases toward the adult age (4934 +/- 309, 1460 +/- 228, 772 +/- 169, and 82 +/- 12 fmol/mg protein at 5, 15, 20, and 30 days of age, respectively) with no change in affinity. At all ages receptors were located in the interstitium, and the decrease in binding was parallel to the decrease in the interstitial to tubular ratio observed with age. AII receptor properties in membrane-rich fractions from prepuberal testes were similar in the rat and rhesus monkey. Binding was time and temperature dependent, reaching a plateau at 60 min at 37 C, and was increased by divalent cations, EGTA, and dithiothreitol up to 0.5 mM. In membranes from prepuberal monkey testes, AII receptors were specific for AII analogs and of high affinity (Kd, 4.2 nM) with a receptor concentration of 7599 +/- 1342 fmol/mg protein. The presence of AII receptors in Leydig cells in rat and primate testes in conjunction with reports of the presence of other components of the renin-angiotensin system in the testes suggests that the peptide has a physiological role in testicular function.

  11. Probing Our Heliospheric History II

    NASA Astrophysics Data System (ADS)

    Wyman, Katherine; Redfield, S.

    2012-05-01

    A physical relationship between our local interstellar medium (ISM), galactic cosmic rays (GCR), and our planetary environment has long been a subject of interest to the astronomical community. Clouds of sufficient density to compress the heliosphere to within 1 AU are commonly seen throughout the galactic environment, including within the Local Bubble (LB). Such a compression would lead to an increase in the GCR flux at 1 AU and would have drastic consequences for many planetary processes such as atmospheric chemistry, lightning production, cloud cover, and DNA mutation rates for surface organisms. Prior to this work, we derived a column density profile of the ISM toward 49 bright stars along a narrow cone centered on the historical solar path. High resolution spectra were taken of NaI and CaII absorption out to a distance of 610 pc, with a median separation distance of 11 pc between adjacent stars. No absorption is seen out to a distance of 120 pc (consistent with the LB), but a complex number of absorbers is seen beyond. We now present the detection of several distinct clouds, their associated column densities, radial velocities, inferred distances, and size constraints. This combination of cloud properties allows us to derive a volume density profile of the ISM in the Sun's “rear-view mirror,” which represents one plausible record of actual ISM encounters for the Sun. We also make use of empirical relations to determine the effect these clouds would have on the historical heliosphere. Our analysis suggests that within the last 10 million years, if the Sun encountered a cloud with the same properties as we have detected along the solar historical trajectory, the Sun's termination shock would have resided inside the orbit of Uranus, with a GCR flux at Earth an order of magnitude greater than it is currently.

  12. The VRI colours of H II galaxies

    NASA Astrophysics Data System (ADS)

    Telles, Eduardo; Terlevich, Roberto

    1997-03-01

    We present a high spatial resolution CCD surface photometry study in the optical V, R and I broad-band filters of a sample of 15 H II galaxies. Narrow-band imaging allows the separation of the emission-line region from the extended parts of the galaxy. The latter are assumed to represent the underlying galaxy in H II galaxies; thus the colours of the underlying galaxy are measured. The colours of the underlying stellar continuum within the starburst are also derived by subtracting the contribution of the emission lines falling in the broad-band filters. The distribution of colours of the underlying galaxy in H II galaxies is similar to the colours of other late-type low surface brightness galaxies, which suggests a close kinship of these with the quiescent phases of H II galaxies. However, comparison wtih recent evolutionary population synthesis models shows that the observational errors and the uncertainties in the models are still too large to put strict constraints on their past star formation history. Our analysis of the morphology and structural properties, from contour maps and luminosity profiles, of this sample of 15 H II galaxies agrees with what has been found by Telles and Telles, Melnick & Terlevich, namely that H II galaxies comprise two broad classes segregated by their luminosity; Type I H II galaxies are luminous and have disturbed and irregular outer shapes, while Type II H II galaxies are less luminous and have regular shapes. The outer parts of their profiles are well represented by an exponential, as in other types of known dwarf galaxy.

  13. Characteristics of He II Proximity Profiles

    NASA Astrophysics Data System (ADS)

    Zheng, Wei; Syphers, David; Meiksin, Avery; Kriss, Gerard A.; Schneider, Donald P.; York, Donald G.; Anderson, Scott F.

    2015-06-01

    The proximity profile in the spectra of z≈ 3 quasars, where fluxes extend blueward of the He ii Lyα wavelength 304 (1+z) Å, is one of the most important spectral features in the study of the intergalactic medium (IGM). Based on the Hubble Space Telescope spectra of 24 He ii quasars, we find that the majority of them display a proximity profile, corresponding to an ionization radius as large as 20 Mpc in the source's rest frame. In comparison with those in the H i spectra of the quasars at z ≈ 6, the He ii proximity effect is more prominent and is observed over a considerably longer period of reionization. The He ii proximity zone sizes decrease at higher redshifts, particularly at z\\gt 3.3. This trend is similar to that for H i, signaling an onset of He ii reionization at z≳ 4. For quasar SDSS1253+6817 (z = 3.48), the He ii absorption trough displays a gradual decline and serves as a good case for modeling the He ii reionization. To model such a broad profile requires a quasar radiation field whose energy distribution between 4 and 1 Rydberg is considerably harder than normally assumed. The UV continuum of this quasar is indeed exceptionally steep, and the He ii ionization level in the quasar vicinity is higher than the average level in the IGM. These results are evidence that a very hard EUV continuum from this quasar produces a large ionized zone around it. Distinct exceptions are the two brightest He ii quasars at z ≈ 2.8, for which no significant proximity profile is present, probably implying that they are very young.

  14. LHC II system sensitivity to magnetic fluids

    NASA Astrophysics Data System (ADS)

    Cotae, Vlad; Creanga, Ioan

    2005-03-01

    Experiments have been designed to reveal the influences of ferrofluid treatment and static magnetic field exposure on the photosynthetic system II, where the light harvesting complex (LHC II) controls the ratio chlorophyll a/ chlorophyll b (revealing, indirectly, the photosynthesis rate). Spectrophotometric measurement of chlorophyll content revealed different influences for relatively low ferrofluid concentrations (10-30 μl/l) in comparison to higher concentrations (70-100 μl/l). The overlapped effect of the static magnetic field shaped better the stimulatory ferrofluid action on LHC II system in young poppy plantlets.

  15. CAPPS II: the foundation of aviation security?

    PubMed

    Barnett, Arnold

    2004-08-01

    A new computer system is being developed to classify U.S. air travelers by the degree of terrorist threat they might pose. Reports indicate that the system--called CAPPS II--would use large amounts of information about each passenger, perhaps including such personal details as his or her magazine-subscription behavior. We argue that what is publicly known about CAPPS II raises questions about how substantially the system would improve aviation security. We discuss conditions under which CAPPS II could yield safety benefits, but suggest that it might be more prudent to view the system as one component of future security arrangements rather than the centerpiece of these arrangements.

  16. Level II Ergonomic Analyses, Dover AFB, DE

    DTIC Science & Technology

    1999-02-01

    IERA-RS-BR-TR-1999-0002 UNITED STATES AIR FORCE IERA Level II Ergonomie Analyses, Dover AFB, DE Andrew Marcotte Marilyn Joyce The Joyce...Project (070401881, Washington, DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE 4. TITLE AND SUBTITLE Level II Ergonomie Analyses, Dover...1.0 INTRODUCTION 1-1 1.1 Purpose Of The Level II Ergonomie Analyses : 1-1 1.2 Approach 1-1 1.2.1 Initial Shop Selection and Administration of the

  17. Belle II Physics Prospects, Status and Schedule

    NASA Astrophysics Data System (ADS)

    Bennett, J.

    2016-11-01

    The second generation B-factory at the SuperKEKB facility in Tsukuba, Japan is beginning to take shape. The highly anticipated Belle II experiment will have a rich physics program at the intensity frontier, in complement to existing experiments in the energy frontier. Accelerator commissioning has been making good progress, as has the construction and installation of the Belle II detector. An overview of the physics prospects at Belle II, as well as the status and schedule of the experiment, is presented.

  18. Genetics Home Reference: distal hereditary motor neuropathy, type II

    MedlinePlus

    ... distal hereditary motor neuropathy, type II distal hereditary motor neuropathy, type II Enable Javascript to view the ... PDF Open All Close All Description Distal hereditary motor neuropathy, type II is a progressive disorder that ...

  19. T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene.

    PubMed

    Moon, Eun-Yi; Noh, Young-Wook; Han, Ying-Hao; Kim, Sun-Uk; Kim, Jin-Man; Yu, Dae-Yeul; Lim, Jong-Seok

    2006-02-15

    Peroxiredoxin II (Prx II) is a member of antioxidant enzyme family and it plays a protective role against oxidative damage. Constitutive production of endogenous reactive oxygen species was detected in spleen and bone marrow cells lacking Prx II. Here, we investigated the role of Prx II in immune responses. The total number of splenocytes (especially, the population of S-phase cells and CD3(+) T cells) was significantly higher in Prx II(-/-) mice than in wild type. Number of peripheral blood mononuclear cells (PBMCs) in Prx II(-/-) mice was also higher than wild type. Differentiation of Prx II(-/-) mouse bone marrow cells into CD11c-positive dendritic cells was greater than that of wild type. Transplantation of Prx II(-/-) bone marrow cells into wild type mice increased PBMCs in blood and bone marrow-derived dendritic cells. Prx II deletion enhances concanavalin A (ConA)-induced splenocyte proliferation and mixed lymphocyte reaction (MLR) activity of bone marrow-derived CD11c-positive dendritic cells to stimulate recipient splenocytes. Collectively, these data suggest that Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS).

  20. Selected methods for dissolved iron (II, III) and dissolved sulfide (-II) determinations in geothermal waters

    USGS Publications Warehouse

    Vivit, D.V.; Jenne, E.A.

    1985-01-01

    Dissolved sulfide (-II) and dissolved iron (II, III) were determined in geothermal well water samples collected at Cerro Prieto, Mexico. Most samples consisted of liquid and gas (two phases) at the instant of collection; and a subset of samples, referred to as ' flashed ' samples, consisted of pressurized steam samples which were allowed to condense. Sulfide was determined by sulfide specific ion electrode; Fe(II) and Fe(III) plus Fe(II) were determined spectrophotometrically. The precision and accuracy of the methods were evaluated for these high-silica waters with replicate analyses, spike recoveries, and an alternate method. Direct current (d.c.) argon plasma emission spectrometry was the alternate method used for Fe(III)-plus-Fe(II) analyses. Mean dissolved iron concentrations ranged from 20.2 to 834 micrograms/L (ug/L) as Fe(II) and 26.8 to 904 ug/L as Fe(III) plus Fe(II). Mean sulfide concentrations ranged from about 0.01 to 5.3 mg/L (S-II) Generally, higher S(-II) values and larger Fe(II)/Fe(III) ratios were found in the two-phase samples. These findings suggest that the ' flashed ' samples are at a less reduced state than the two-phase samples. (Author 's abstract)

  1. Increased association of dynamin II with myosin II in ras transformed NIH3T3 cells.

    PubMed

    Jeong, Soon-Jeong; Kim, Su-Gwan; Yoo, Jiyun; Han, Mi-Young; Park, Joo-Cheol; Kim, Heung-Joong; Kang, Seong-Soo; Choi, Baik-Dong; Jeong, Moon-Jin

    2006-08-01

    Dynamin has been implicated in the formation of nascent vesicles through both endocytic and secretory pathways. However, dynamin has recently been implicated in altering the cell membrane shape during cell migration associated with cytoskeleton-related proteins. Myosin II has been implicated in maintaining cell morphology and in cellular movement. Therefore, reciprocal immunoprecipitation was carried out to identify the potential relationship between dynamin II and myosin II. The dynamin II expression level was higher when co-expressed with myosin II in Ras transformed NIH3T3 cells than in normal NIH3T3 cells. Confocal microscopy also confirmed the interaction between these two proteins. Interestingly, exposing the NIH3T3 cells to platelet-derived growth factor altered the interaction and localization of these two proteins. The platelet-derived growth factor treatment induced lamellipodia and cell migration, and dynamin II interacted with myosin II. Grb2, a 24 kDa adaptor protein and an essential element of the Ras signaling pathway, was found to be associated with dynamin II and myosin II gene expression in the Ras transformed NIH3T3 cells. These results suggest that dynamin II acts as an intermediate messenger in the Ras signal transduction pathway leading to membrane ruffling and cell migration.

  2. Pecan nutshell as biosorbent to remove Cu(II), Mn(II) and Pb(II) from aqueous solutions.

    PubMed

    Vaghetti, Julio C P; Lima, Eder C; Royer, Betina; da Cunha, Bruna M; Cardoso, Natali F; Brasil, Jorge L; Dias, Silvio L P

    2009-02-15

    In the present study we reported for the first time the feasibility of pecan nutshell (PNS, Carya illinoensis) as an alternative biosorbent to remove Cu(II), Mn(II) and Pb(II) metallic ions from aqueous solutions. The ability of PNS to remove the metallic ions was investigated by using batch biosorption procedure. The effects such as, pH, biosorbent dosage on the adsorption capacities of PNS were studied. Four kinetic models were tested, being the adsorption kinetics better fitted to fractionary-order kinetic model. Besides that, the kinetic data were also fitted to intra-particle diffusion model, presenting three linear regions, indicating that the kinetics of adsorption should follow multiple sorption rates. The equilibrium data were fitted to Langmuir, Freundlich, Sips and Redlich-Peterson isotherm models. Taking into account a statistical error function, the data were best fitted to Sips isotherm model. The maximum biosorption capacities of PNS were 1.35, 1.78 and 0.946mmolg(-1) for Cu(II), Mn(II) and Pb(II), respectively.

  3. Adsorption of copper (II), chromium (III), nickel (II) and lead (II) ions from aqueous solutions by meranti sawdust.

    PubMed

    Rafatullah, M; Sulaiman, O; Hashim, R; Ahmad, A

    2009-10-30

    The present study proposed the use of meranti sawdust in the removal of Cu(II), Cr(III), Ni(II) and Pb(II) ions from synthetic aqueous solutions. Batch adsorption studies showed that meranti sawdust was able to adsorb Cu(II), Cr(III), Ni(II) and Pb(II) ions from aqueous solutions in the concentration range 1-200mg/L. The adsorption was favoured with maximum adsorption at pH 6, whereas the adsorption starts at pH 1 for all metal ions. The effects of contact time, initial concentration of metal ions, adsorbent dosage and temperature have been reported. The applicability of Langmuir, Freundlich, and Dubinin-Radushkevich (D-R) isotherm was tried for the system to completely understand the adsorption isotherm processes. The adsorption kinetics tested with pseudo-first-order and pseudo-second-order models yielded high R(2) values from 0.850 to 0.932 and from 0.991 to 0.999, respectively. The meranti sawdust was found to be cost effective and has good efficiency to remove these toxic metal ions from aqueous solution.

  4. Synthesis and studies on Cu(II), Co(II), Ni(II) complexes of Knoevenagel β-diketone ligands.

    PubMed

    Sumathi, S; Tharmaraj, P; Sheela, C D; Anitha, C

    2012-11-01

    Transition metal complexes of various acetylacetone based ligands of the type ML [where M=Cu(II), Ni(II), Co(II); L=3-(aryl)-pentane-2,4-dione] have been synthesized. The structural features have been derived from their elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis, (1)H NMR, Mass and ESR spectral studies. Conductivity measurements reveal that all the complexes are non-electrolytic in nature. Spectroscopic and other analytical data of the complexes suggest octahedral geometry for other metal(II) complexes. The redox behavior of the copper(II) complexes have been studied by cyclic voltammetry. The free ligands and their metal complexes have been screened for their in vitro biological activities against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus as well as the fungus Candida albicans by well diffusion method. The zone of inhibition value indicates that the most of the metal(II) complexes are found to possess increased activities compared to those of the free ligands. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligands (L1-L3) was found to be considerable effect than that of urea and KDP (potassium dihydrogen phosphate).

  5. Synthesis and studies on Cu(II), Co(II), Ni(II) complexes of Knoevenagel β-diketone ligands

    NASA Astrophysics Data System (ADS)

    Sumathi, S.; Tharmaraj, P.; Sheela, C. D.; Anitha, C.

    2012-11-01

    Transition metal complexes of various acetylacetone based ligands of the type ML [where M = Cu(II), Ni(II), Co(II); L = 3-(aryl)-pentane-2,4-dione] have been synthesized. The structural features have been derived from their elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis, 1H NMR, Mass and ESR spectral studies. Conductivity measurements reveal that all the complexes are non-electrolytic in nature. Spectroscopic and other analytical data of the complexes suggest octahedral geometry for other metal(II) complexes. The redox behavior of the copper(II) complexes have been studied by cyclic voltammetry. The free ligands and their metal complexes have been screened for their in vitro biological activities against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus as well as the fungus Candida albicans by well diffusion method. The zone of inhibition value indicates that the most of the metal(II) complexes are found to possess increased activities compared to those of the free ligands. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligands (L1-L3) was found to be considerable effect than that of urea and KDP (potassium dihydrogen phosphate).

  6. Kinetics of homogeneous and surface-catalyzed mercury(II) reduction by iron(II)

    USGS Publications Warehouse

    Amirbahman, Aria; Kent, Douglas B.; Curtis, Gary P.; Marvin-DiPasquale, Mark C.

    2013-01-01

    Production of elemental mercury, Hg(0), via Hg(II) reduction is an important pathway that should be considered when studying Hg fate in environment. We conducted a kinetic study of abiotic homogeneous and surface-catalyzed Hg(0) production by Fe(II) under dark anoxic conditions. Hg(0) production rate, from initial 50 pM Hg(II) concentration, increased with increasing pH (5.5–8.1) and aqueous Fe(II) concentration (0.1–1 mM). The homogeneous rate was best described by the expression, rhom = khom [FeOH+] [Hg(OH)2]; khom = 7.19 × 10+3 L (mol min)−1. Compared to the homogeneous case, goethite (α-FeOOH) and hematite (α-Fe2O3) increased and γ-alumina (γ-Al2O3) decreased the Hg(0) production rate. Heterogeneous Hg(0) production rates were well described by a model incorporating equilibrium Fe(II) adsorption, rate-limited Hg(II) reduction by dissolved and adsorbed Fe(II), and rate-limited Hg(II) adsorption. Equilibrium Fe(II) adsorption was described using a surface complexation model calibrated with previously published experimental data. The Hg(0) production rate was well described by the expression rhet = khet [>SOFe(II)] [Hg(OH)2], where >SOFe(II) is the total adsorbed Fe(II) concentration; khet values were 5.36 × 10+3, 4.69 × 10+3, and 1.08 × 10+2 L (mol min)−1 for hematite, goethite, and γ-alumina, respectively. Hg(0) production coupled to reduction by Fe(II) may be an important process to consider in ecosystem Hg studies.

  7. Copper(II) and lead(II) removal from aqueous solution by water treatment residues.

    PubMed

    Castaldi, Paola; Silvetti, Margherita; Garau, Giovanni; Demurtas, Daniela; Deiana, Salvatore

    2015-01-01

    In this study, we investigated the ability of Fe- and Al-based water treatment residues (Fe- and Al-WTR) to accumulate Pb(II) and Cu(II) at pH 4.5. The role of the inorganic and organic fractions of WTRs in metals sorption was also assessed. Sorption isotherms showed a higher sorption of Pb(II) by both WTRs with respect to Cu(II) (e.g. 0.105 and 0.089 mmol g(-1) of Pb(II) and Cu(II) respectively sorbed by Fe-WTR). Fe-WTR revealed a stronger sorbent for both metals than Al-WTR. The amount of Pb(II) and Cu(II) sorbed by Fe-WTR was about the 69% and 63% higher than that sorbed by the Al-WTR. The organic matter of Fe- and Al-WTR contributed to about 26% and 8.5% respectively in the sorption of both metals. The sequential extraction procedure showed that the greatest amount of metals sorbed by both WTRs were tightly bound and not extractable, and this was particularly apparent for Cu(II). The FT-IR spectra indicated the formation of inner-sphere complexes between the Fe(Al)-O nucleus and Pb(II) and Cu(II). Moreover, the FT-IR spectra also suggested that the humic fraction of WTRs interacted, through the carboxylate groups, with Cu(II) and Pb(II) by forming mainly monodentate and bidentate complexes, respectively.

  8. Rapid and wide-range determination of Cd(II), Pb(II), Cu(II) and Hg(II) in fish tissues using light addressable potentiometric sensor.

    PubMed

    Zhang, Wen; Xu, Yiwei; Tahir, Haroon E; Zou, Xiaobo; Wang, Ping

    2017-04-15

    A rapid and wide-range method, based on light addressable potentiometric sensor (LAPS), is introduced into determination of Cd(II), Pb(II), Cu(II) and Hg(II) in fish tissues. A compact LAPS module is prepared by integrating four LAPS chips specifically sensitive to target elements. Its responses in digestions from various settings are investigated to find suitable factors. Analytical properties of this method are evaluated in consequent experiments under optimized conditions. Measurement range for each target element exceeds 0.1 to 1000mgL(-1), and response time is less than 10s. Accuracy, precision and selectivity of the proposed method are also well defined in measurements. It is successively performed to detect the target elements in real fish samples from 4 species, and obtained results are consistent with certified method.

  9. Psychological Action and Structure in "Richard II."

    ERIC Educational Resources Information Center

    Toole, William B., III

    1978-01-01

    Explores the theme that the suffering arising from Richard II's loss of power, a power that consisted more of appearance than of intrinsic worth, led him to spiritual growth and the development of real value as a person. (MB)

  10. Resistance domain in type II superconductors

    SciTech Connect

    Gurevich, A.V.; Mints, R.G.

    1980-01-05

    We show that traveling domains with a finite resistance can exist in type II superconductors in the presence of a transport current. An experiment in which this effect generates an alternating electric field and current is proposed.

  11. Zodiac II: Debris Disk Imaging Potential

    NASA Technical Reports Server (NTRS)

    Traub Wesley; Bryden, Geoff; Stapelfeldt, Karl; Chen, Pin; Trauger, John

    2011-01-01

    Zodiac II is a proposed coronagraph on a balloon-borne platform, for the purpose of observing debris disks around nearby stars. Zodiac II will have a 1.2-m diameter telescope mounted in a balloon-borne gondola capable of arcsecond quality pointing, and with the capability to make long-duration (several week) flights. Zodiac II will have a coronagraph able to make images of debris disks, meaning that its scattered light speckles will be at or below an average contrast level of about 10(exp -7) in three narrow (7 percent) bands centered on the V band, and one broad (20%) one at I band. We will discuss the potential science to be done with Zodiac II.

  12. Far Outer Galaxy H II Regions

    NASA Technical Reports Server (NTRS)

    Rudolph, A. L.; deGues, E. J.; Brand, J.; Wouterloot, J. G. A.; Gross, Anthony R. (Technical Monitor)

    1994-01-01

    We have made a multifrequency (6, 3.6, and 2 cm), high-resolution (3"-6"), radio continuum survey of IRAS selected sources from the catalogue of Wouterloot & Brand (1989) to search for and study H II regions in the far outer Galaxy. We identified 31 sources in this catalog with well determined galactocentric distances, and with R approx.. greater than 15 kpc and L(sub FIR) approx.greater than 10(exp 4) solar luminosity, indicating the presence of high-mass star-formation. We have observed 11 of these sources with the Very Large Array (VLA). We observed the sources at 6 and 2 cm using "scaled arrays", making possible a direct and reliable comparison of the data at these two wavelengths for the determination of spectral indices. We detected a total of 12 radio sources, of which 10 have spectral indices consistent with optically-thin free-free emission from H II regions. Combined with previous VLA observations by other investigators, we have data on a total of 15 H II regions at galactocentric distances of 15 to 18.2kpc, among the most remote H II regions found in our Galaxy. The sizes of the H II regions range from approx. less than 0.10 to 2.3 pc. Using the measured fluxes and sizes, we determine the electron densities, emission measures, and excitation parameters of the H II regions, as well as the fluxes of Lyman continuum photons needed to keep the nebulae ionized. The sizes and electron densities are consistent with most of the sources detected in this survey being compact or ultracompact H II regions. Seven of the fifteen H II regions have sizes approx. less than 0.20 pc. Assuming simple pressure-driven expansion of the H II regions, these sizes indicate ages approx. less than 5 x 10(exp 4) yr, or only 1% of the lifetime of an O star, which implies an unlikely overabundance of O stars in the outer Galaxy. Thus, the large number of compact H II regions suggests that the time these regions spend in a compact phase must be much longer than their dynamical

  13. Courseware Review: Vernier Software: Precision Timer II.

    ERIC Educational Resources Information Center

    Park, John C.

    1988-01-01

    Reviews "Vernier Software: Precision Timer II" for high school through college mechanics. Introduces 14 different modes including pulse time, pendulum timer, bouncer timer, gate timer, collision timers, and stroke calibration. Provides two typical displays and ratings of the software. (YP)

  14. Enzymatic synthesis of lipid II and analogues.

    PubMed

    Huang, Lin-Ya; Huang, Shih-Hsien; Chang, Ya-Chih; Cheng, Wei-Chieh; Cheng, Ting-Jen R; Wong, Chi-Huey

    2014-07-28

    The emergence of antibiotic resistance has prompted active research in the development of antibiotics with new modes of action. Among all essential bacterial proteins, transglycosylase polymerizes lipid II into peptidoglycan and is one of the most favorable targets because of its vital role in peptidoglycan synthesis. Described in this study is a practical enzymatic method for the synthesis of lipid II, coupled with cofactor regeneration, to give the product in a 50-70% yield. This development depends on two key steps: the overexpression of MraY for the synthesis of lipid I and the use of undecaprenol kinase for the preparation of polyprenol phosphates. This method was further applied to the synthesis of lipid II analogues. It was found that MraY and undecaprenol kinase can accept a wide range of lipids containing various lengths and configurations. The activity of lipid II analogues for bacterial transglycolase was also evaluated.

  15. PEP-II Status and Outlook

    SciTech Connect

    Wienands, H.U.; Biagini, M.E.; Decker, F.J.; Donald, M.H.; Ecklund, S.; Fisher, A.; Holtzapple, R.L.; Iverson, R.H.; Krejcik, P.; Kulikov, A.V.; Meyer, T.; Nelson, J.; Novokhatski, A.; Reichel, I.; Sullivan, M.; Seeman, J.T.; Turner, J.; Steier, C.; Zisman, M.S.; /LBL, Berkeley

    2012-04-24

    PEP-II/BABAR are presently in their second physics run. With machine and detector performance and reliability at an all-time high, almost 51 fb{sup -1} have been integrated by BABAR up to mid-October 2001. PEP-II luminosity has reached 4.4 x 10{sup 33} cm{sup -2} s{sup -1} and our highest monthly delivered luminosity has been above 6 pb{sup -1}, exceeding the performance parameters given in the PEP-II CDR by almost 50%. The increase compared to the first run in 2000 has been achieved by a combination of beam-current increase and beam-size decrease. In this paper we will summarize the PEP-II performance and the present limitations as well as our plans to further increase machine performance.

  16. Achondrogenesis type II, abnormalities of extracellular matrix.

    PubMed

    Horton, W A; Machado, M A; Chou, J W; Campbell, D

    1987-09-01

    Immune and lectin histochemical and microchemical methods were employed to study growth cartilage from seven cases of achondrogenesis type II (Langer-Saldino). The normal architecture of the epiphyseal and growth plate cartilage was replaced by a morphologically heterogeneous tissue. Some areas were comprised of vascular canals surrounded by extensive fibrous tissue and enlarged cells that had the appearance and histochemical characteristics of hypertrophic chondrocytes. Other areas contained a mixture of cells ranging from small to the enlarged chondrocytes. The extracellular matrix in the latter areas was more abundant and had characteristics of both precartilage mesenchymal matrix and typical cartilage matrix; it contained types I and II collagen, cartilage proteoglycan, fibronectin, and peanut agglutinin binding glycoconjugate(s). Peptide mapping of cyanogen bromide cartilage collagen peptides revealed the presence of types I and II collagen. These observations could be explained by a defect in the biosynthesis of type II collagen or in chondrocyte differentiation.

  17. Achondrogenesis II-hypochondrogenesis: variability versus heterogeneity.

    PubMed

    Borochowitz, Z; Ornoy, A; Lachman, R; Rimoin, D L

    1986-06-01

    Recently hypochondrogenesis was described as a form of neonatally lethal dwarfism said to resemble spondyloepiphyseal dysplasia congenita radiographically and achondrogenesis II morphologically. Because of the difficulty in distinguishing radiographically between mild achondrogenesis II and severe hypochondrogenesis, we performed a clinical, radiographic, and morphologic study of 24 cases originally classified as either achondrogenesis II or hypochondrogenesis, in an attempt to distinguish between heterogeneity and clinical variability. Review of the radiographic findings in these cases show a fairly continuous spectrum of bony defects, rather than two distinct radiographic syndromes. Chondro-osseous histology and ultrastructure was similar in all cases regardless of severity and was characterized by hypervascularity and hypercellularity of the cartilage with multiple small, round dilated cysternae of rough endoplasmic reticulum. These findings suggest that hypochondrogenesis and achondrogenesis type II represent a spectrum with marked phenotypic variability.

  18. NSLS-II Transport Line Progress

    SciTech Connect

    Fliller R. P.; Wahl, W.; Anderson, A.; Benish, B.; DeBoer, W.; Ganetis, G.; Heese, R.; Hseuh, H.-C.; Hu, J.-P.; Johanson, M.P.; Kosciuk, B.N.; Padrazo, D.; Roy, K.; Shaftan, T.; Singh, O.; Tuozzolo, J.; Wang, G.

    2012-05-20

    The National Synchrotron Light Source II (NSLS-II) is a state-of-the-art 3-GeV third generation light source currently under construction at Brookhaven National Laboratory. The NSLS-II injection system consists of a 200 MeV linac, a 3-GeV booster synchrotron and associated transfer lines. The first part of the Linac to Booster Transport (LBT) line has been installed for linac commissioning. This part includes all components necessary to commission the NSLS-II linac. The second part of this transport line is undergoing installation. Initial results of hardware commissioning will be discussed. The Booster to Storage Ring (BSR) transport line underwent a design review. The first part of the BSR transport line, consisting of all components necessary to commission the booster will be installed in 2012 for booster commissioning. We report on the final design of the BSR line along with the plan to commission the booster.

  19. Neutral (bis-beta-diketonato) iron(III), cobalt(II), nickel(II), copper(II) and zinc(II) metallocycles: structural, electrochemical and solvent extraction studies.

    PubMed

    Clegg, Jack K; Bray, David J; Gloe, Kerstin; Gloe, Karsten; Hayter, Michael J; Jolliffe, Katrina A; Lawrance, Geoffrey A; Meehan, George V; McMurtrie, John C; Lindoy, Leonard F; Wenzel, Marco

    2007-05-07

    Neutral dimeric metallocyclic complexes of type [M(2)(L(1))(2)B(n)] (where M = cobalt(II), nickel(II) and zinc(II), L(1) is the doubly deprotonated form of a 1,3-aryl linked bis-beta-diketone ligand of type 1,3-bis(RC(O)CH(2)C(O))C(6)H(4) (R=Me, n-Pr, t-Bu) and B is pyridine (Py) or 4-ethylpyridine (EtPy)) have been synthesised, adding to similar complexes already reported for copper(II). New lipophilic ligand derivatives with R = octyl or nonyl were also prepared for use in solvent extraction experiments. Structural, electrochemical and solvent extraction investigations of selected metal complex systems from the above series are reported, with the X-ray structures of [Co(2)(L(1))(2)(Py)(4)] x 2.25CHCl(3) x 0.5H(2)O (R=Pr), [Co(2)(L(1))(2)(EtPy)(4)] (R=t-Bu), [Ni(2)(L(1))(2)(EtPy)(4)] (R=t-Bu), [Zn(2)(L(1))(2)(EtPy)(2)] (R=Me) and [Zn(2)(L(1))(2)(EtPy)(4)] (R=t-Bu) being presented. The electrochemistry of H(2)L(1) (R=t-Bu) and of [Fe(2)(L(1))(3)], [Co(2)(L(1))(2)(Py)(4)], [Ni(2)(L(1))(2)(Py)(4)], [Cu(2)(L(1))(2)] and [Zn(2)(L(1))(2)(Py)(2)] has been examined. Oxidative processes for the complexes are dominantly irreversible, but several examples of quasireversible behaviour were observed and support the assignment of an anodic process, seen between +1.0 and +1.6 V, as a metal-centred oxidation. The reduction processes for the respective metal complexes are not simple, and irreversible in most cases. Solvent extraction studies (water/chloroform) involving variable concentrations of metal, bis-beta-diketone and heterocyclic base have been performed for cobalt(II) and zinc(II) using a radiotracer technique to probe the stoichiometries of the extracted species in each case. Synergism was observed when 4-ethylpyridine was added to the bis-beta-diketone ligand in the chloroform phase. Competitive extraction studies show a clear uptake preference for copper(II) over cobalt(II), nickel(II), zinc(II) and cadmium(II).

  20. Removal of Pb(II), Cd(II), Cu(II), and Zn(II) by hematite nanoparticles: effect of sorbent concentration, pH, temperature, and exhaustion.

    PubMed

    Shipley, Heather J; Engates, Karen E; Grover, Valerie A

    2013-03-01

    Nanoparticles offer the potential to improve environmental treatment technologies due to their unique properties. Adsorption of metal ions (Pb(II), Cd(II), Cu(II), Zn(II)) to nanohematite was examined as a function of sorbent concentration, pH, temperature, and exhaustion. Adsorption experiments were conducted with 0.05, 0.1, and 0.5 g/L nanoparticles in a pH 8 solution and in spiked San Antonio tap water. The adsorption data showed the ability of nanohematite to remove Pb, Cd, Cu, and Zn species from solution with adsorption increasing as the nanoparticle concentration increased. At 0.5 g/L nanohematite, 100 % Pb species adsorbed, 94 % Cd species adsorbed, 89 % Cu species adsorbed and 100 % Zn species adsorbed. Adsorption kinetics for all metals tested was described by a pseudo second-order rate equation with lead having the fastest rate of adsorption. The effect of temperature on adsorption showed that Pb(II), Cu(II), and Cd(II) underwent an endothermic reaction, while Zn(II) underwent an exothermic reaction. The nanoparticles were able to simultaneously remove multiple metals species (Zn, Cd, Pb, and Cu) from both a pH 8 solution and spiked San Antonio tap water. Exhaustion experiments showed that at pH 8, exhaustion did not occur for the nanoparticles but adsorption does decrease for Cd, Cu, and Zn species but not Pb species. The strong adsorption coupled with the ability to simultaneously remove multiple metal ions offers a potential remediation method for the removal of metals from water.

  1. NSLS-II Radio Frequency Systems

    SciTech Connect

    Rose J.; Gao F.; Goel, A.; Holub, B.; Kulpin, J.; Marques, C.; Yeddulla, M.

    2015-05-03

    The National Synchrotron Light Source II is a 3 GeV X-ray user facility commissioned in 2014. The NSLS-II RF system consists of the master oscillator, digital low level RF controllers, linac, booster and storage ring RF sub-systems, as well as a supporting cryogenic system. Here we will report on RF commissioning and early operation experience of the system.

  2. Nickel(II) biosorption by Rhodotorula glutinis.

    PubMed

    Suazo-Madrid, Alicia; Morales-Barrera, Liliana; Aranda-García, Erick; Cristiani-Urbina, Eliseo

    2011-01-01

    The present study reports the feasibility of using Rhodotorula glutinis biomass as an alternative low-cost biosorbent to remove Ni(II) ions from aqueous solutions. Acetone-pretreated R. glutinis cells showed higher Ni(II) biosorption capacity than untreated cells at pH values ranging from 3 to 7.5, with an optimum pH of 7.5. The effects of other relevant environmental parameters, such as initial Ni(II) concentration, shaking contact time and temperature, on Ni(II) biosorption onto acetone-pretreated R. glutinis were evaluated. Significant enhancement of Ni(II) biosorption capacity was observed by increasing initial metal concentration and temperature. Kinetic studies showed that the kinetic data were best described by a pseudo-second-order kinetic model. Among the two-, three-, and four-parameter isotherm models tested, the Fritz-Schluender model exhibited the best fit to experimental data. Thermodynamic parameters (activation energy, and changes in activation enthalpy, activation entropy, and free energy of activation) revealed that the biosorption of Ni(II) ions onto acetone-pretreated R. glutinis biomass is an endothermic and non-spontaneous process, involving chemical sorption with weak interactions between the biosorbent and Ni(II) ions. The high sorption capacity (44.45 mg g(-1) at 25°C, and 63.53 mg g(-1) at 70°C) exhibited by acetone-pretreated R. glutinis biomass places this biosorbent among the best adsorbents currently available for removal of Ni(II) ions from aqueous effluents.

  3. NSLS-II Beam Diagnostics Overview

    SciTech Connect

    Singh,O.; Alforque, R.; Bacha, B.; Blednykh, A.; Cameron, P.; Cheng, W.; Dalesio, L. B.; Della Penna, A. J.; doom, L.; Fliller, R. P.; Ganetis, G.; Heese, R.; Hseuh, H-C.; Johnson, E. D.; Kosciuk, b. N.; Kramer, S. L.; Krinsky, S.; Mead, J.; Ozaki, S.; Padrazo, D.; Pinayev, I.; Ravindranath, R. V.; Rose, J.; Shaftan, T.; Sharma, S.; Skaritka, J.; Tanabe, T.; Tian, Y.; Willeke, F. J.; Yu, L-H.

    2009-05-04

    A new 3rd generation light source (NSLS-II) is in the early stages of construction at Brookhaven National Laboratory. The NSLS-II facility will provide ultra high brightness and flux with exceptional beam stability. It presents several challenges for diagnostics and instrumentation, related to the extremely small emittance. In this paper, we present an overview of all planned instrumentation systems, results from research and development activities; and then focus on other challenging aspects.

  4. Mechanisms of angiotensin II natriuresis and antinatriuresis.

    PubMed

    Olsen, M E; Hall, J E; Montani, J P; Guyton, A C; Langford, H G; Cornell, J E

    1985-08-01

    The aim of this study was to determine the role of changes in renal arterial pressure (RAP), renal hemodynamics, and tubular reabsorption in mediating the natriuretic and antinatriuretic actions of angiotensin II (ANG II). In seven anesthetized dogs, endogenous ANG II formation was blocked with captopril, and ANG II was infused intravenously at rates of 5-1,215 ng X kg-1 X min-1 while RAP was either servo-controlled at the preinfusion level or permitted to increase. When RAP was servo-controlled, ANG II infusion at all rates from 5-1,215 ng X kg-1 X min-1 decreased urinary sodium excretion (UNaV) and fractional sodium excretion (FENa) while increasing fractional reabsorption of lithium (FRLi) (an index of proximal tubular fractional sodium reabsorption) and causing no change in calculated distal tubule fractional sodium reabsorption (FRDNa). When RAP was permitted to increase, ANG II infusion rates up to 45 ng X kg-1. min-1 also decreased UNaV and FENa while increasing FRLi and causing no change in FRDNa. However, at 135 ng X kg-1 X min-1 and above, UNaV and FENa increased while FRLi and FRDNa decreased when RAP was allowed to rise, even though renal blood flow and filtration fraction were not substantially different from the values observed when RAP was servo-controlled. Filtered sodium load was slightly higher when RAP was permitted to increase during ANG II infusion compared with when RAP was servo-controlled, although the differences were not statistically significant. Thus, even very large doses of ANG II cause antinatriuresis when RAP is prevented from increasing.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Antenatal diagnosis of achondrogenesis type II.

    PubMed

    Kodandapani, S; Ramkumar, V

    2009-01-01

    Achondrogenesis is a lethal congenital chondrodystrophy characterized by extreme micromelia, small thorax and polyhydramnios. We describe a case of achondrogenesis type II (Langer-Saldino achondrogenesis). Prenatal ultrasonography at 22-weeks gestation revealed a fetus with large head, short neck and chest, prominent abdomen and short limbs. Pregnancy was terminated. Radiologic examination of neonate revealed features of achondrogenesis type II. Routine ultrasound screening made early detection and timely management possible.

  6. The Ssart of Run II at CDF

    SciTech Connect

    Marco Rescigno

    2002-10-29

    After a hiatus of almost 6 years and an extensive upgrade, Tevatron, the world largest proton-antiproton collider, has resumed the operation for the so called RUN II. In this paper we give a brief overview of the many new features of the Tevatron complex and of the upgraded CDF experiment, and show the presently achieved detector performances as well as highlights of the RUN II physics program in the beauty and electroweak sector.

  7. Status of the CDF II experiment

    SciTech Connect

    S. Rolli

    2002-08-14

    The status of the CDF II experiment is described. Since operations start-up for run II data taking in March 2001, the CDF detector has been commissioned using about 20 pb{sup -1} of data provided by the Tevatron (utilized about 4-8). Most detector components are ready for physics quality data. The goal is to present the first physics results by summer-fall 2002.

  8. Synthesis and characterization of hydroxyapatite nanoparticles impregnated on apple pomace to enhanced adsorption of Pb(II), Cd(II), and Ni(II) ions from aqueous solution.

    PubMed

    Chand, Piar; Pakade, Yogesh B

    2015-07-01

    Hydroxyapatite nanoparticles were synthesized, characterized, and impregnated onto apple pomace surface (HANP@AP) for efficient removal of Pb(II), Cd(II), and Ni(II) ions from water. HANP@AP was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), transmission electron microscope (TEM), X-ray diffraction (XRD), and surface area analysis. Batch sorption studies were carried out to investigate the influence of different parameters as amount of dose (g), pH, time (min), and initial concentration (mg L(-1)) on adsorption process. Experimental kinetic data followed pseudo-second-order model and equilibrium data well fitted to Langmuir adsorption model with maximum adsorption capacities of 303, 250, and 100 mg g(-1) for Pb(II), Cd(II), and Ni(II) ions, respectively. Competitive adsorption of Pb(II), Cd(II), and Ni(II) ions in presences of each other was studied to evaluate the removal efficiency of HANP@AP against multi metal-loaded water. HANP@AP was successfully applied to real industrial wastewater with 100 % removal of all three metal ions even at high concentration. HANP@AP could be recycled for four, four, and three cycles in case of Pb(II), Cd(II) and Ni(II), respectively. The study showed that HANP@AP is fast, cost effective, and environmental friendly adsorbent for removal of Pb(II), Cd(II), and Ni(II) ions from real industrial wastewater.

  9. Preferred crystallographic orientation in the ice I ← II transformation and the flow of ice II

    USGS Publications Warehouse

    Bennett, K.; Wenk, H.-R.; Durham, W.B.; Stern, L.A.; Kirby, S.H.

    1997-01-01

    The preferred crystallographic orientation developed during the ice I ← II transformation and during the plastic flow of ice II was measured in polycrystalline deuterium oxide (D2O) specimens using low-temperature neutron diffraction. Samples partially transformed from ice I to II under a non-hydrostatic stress developed a preferred crystallographic orientation in the ice II. Samples of pure ice II transformed from ice I under a hydrostatic stress and then when compressed axially, developed a strong preferred orientation of compression axes parallel to (1010). A match to the observed preferred orientation using the viscoplastic self-consistent theory was obtained only when (1010) [0001] was taken as the predominant slip system in ice II.

  10. Pb(II) and Cd(II) removal from aqueous solutions by olive cake.

    PubMed

    Doyurum, Sabriye; Celik, Ali

    2006-11-02

    The removal of heavy metals from wastewater using olive cake as an adsorbent was investigated. The effect of the contact time, pH, temperature, and concentration of adsorbate on adsorption performance of olive cake for Pb(II) and Cd(II) ions were examined by batch method. Adsorption of Pb(II) and Cd(II) in aqueous solution onto olive cake was studied in single component. After establishing the optimum conditions, elution of these ions from the adsorbent surface was also examined. The optimum sorption conditions were determined for two elements. Maximum desorption of the Pb(II) and Cd(II) ions were found to be 95.92 and 53.97% by 0.5M HNO(3) and 0.2M HCl, respectively. The morphological analysis of the olive cake was performed by the scanning electron microscopy (SEM).

  11. Differential effect of solution conditions on the conformation of the actinoporins Sticholysin II and Equinatoxin II.

    PubMed

    Fauth, Edson V F; Cilli, Eduardo M; Ligabue-Braun, Rodrigo; Verli, Hugo

    2014-12-01

    Actinoporins are a family of pore-forming proteins with hemolytic activity. The structural basis for such activity appears to depend on their correct folding. Such folding encompasses a phosphocholine binding site, a tryptophan-rich region and the activity-related N-terminus segment. Additionally, different solution conditions are known to be able to influence the pore formation by actinoporins, as for Sticholysin II (StnII) and Equinatoxin II (EqtxII). In this context, the current work intends to characterize the influence of distinct solution conditions in the conformational behavior of these proteins through molecular dynamics (MD) simulations. The obtained data offer structural insights into actinoporins dynamics in solution, characterizing its conformational behavior at the atomic level, in accordance with previous experimental data on StnII and EqtxII hemolytic activities.

  12. Genetic heterogeneity of Usher syndrome type II.

    PubMed Central

    Pieke Dahl, S; Kimberling, W J; Gorin, M B; Weston, M D; Furman, J M; Pikus, A; Möller, C

    1993-01-01

    Usher syndrome is an autosomal recessive disorder characterised by retinitis pigmentosa and congenital sensorineural hearing loss. A gene for Usher syndrome type II (USH2) has been localised to chromosome 1q32-q41. DNA from a family with four of seven sibs affected with clinical characteristics of Usher syndrome type II was genotyped using markers spanning the 1q32-1q41 region. These included D1S70 and D1S81, which are believed to flank USH2. Genotypic results and subsequent linkage analysis indicated non-linkage of this family to these markers. The A test analysis for heterogeneity with this family and 32 other Usher type II families was statistically significant at p < 0.05. Further clinical evaluation of this family was done in light of the linkage results to determine if any phenotypic characteristics would allow for clinical identification of the unlinked type. No clear phenotypic differences were observed; however, this unlinked family may represent a previously unreported subtype of Usher type II characterised by a milder form of retinitis pigmentosa and mild vestibular abnormalities. Heterogeneity of Usher syndrome type II complicates efforts to isolate and clone Usher syndrome genes using linkage analysis and limits the use of DNA markers in early detection of Usher type II. Images PMID:7901420

  13. Group II Introns and Their Protein Collaborators

    NASA Astrophysics Data System (ADS)

    Solem, Amanda; Zingler, Nora; Pyle, Anna Marie; Li-Pook-Than, Jennifer

    Group II introns are an abundant class of autocatalytic introns that excise themselves from precursor mRNAs. Although group II introns are catalytic RNAs, they require the assistance of proteins for efficient splicing in vivo. Proteins that facilitate splicing of organellar group II introns fall into two main categories: intron-encoded maturases and host-encoded proteins. This chapter will focus on the host proteins that group II introns recruited to ensure their function. It will discuss the great diversity of these proteins, define common features, and describe different strategies employed to achieve specificity. Special emphasis will be placed on DEAD-box ATPases, currently the best studied example of host-encoded proteins with a role in group II intron splicing. Since the exact mechanisms by which splicing is facilitated is not known for any of the host proteins, general mechanistic strategies for protein-mediated RNA folding are described and assessed for their potential role in group II intron splicing.

  14. 40 CFR Table 1 to Subpart II of... - General Provisions of Applicability to Subpart II

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Reference Applies to subpart II Comment 63.1(a)(1)-(3) Yes. 63.1(a)(4) Yes Subpart II clarifies the applicability of each paragraph in subpart A to sources subject to subpart II. 63.1(a)(5)-(7) Yes 63.1(a)(8) No Discusses State programs. 63.1(a)(9)-(14) Yes 63.1(b)(1) Yes § 63.781 specifies applicability in more...

  15. Competitive sorption of Pb(II), Cu(II) and Ni(II) on carbonaceous nanofibers: A spectroscopic and modeling approach.

    PubMed

    Ding, Congcong; Cheng, Wencai; Wang, Xiangxue; Wu, Zhen-Yu; Sun, Yubing; Chen, Changlun; Wang, Xiangke; Yu, Shu-Hong

    2016-08-05

    The competitive sorption of Pb(II), Cu(II) and Ni(II) on the uniform carbonaceous nanofibers (CNFs) was investigated in binary/ternary-metal systems. The pH-dependent sorption of Pb(II), Cu(II) and Ni(II) on CNFs was independent of ionic strength, indicating that inner-sphere surface complexation dominated sorption Pb(II), Cu(II) and Ni(II) on CNFs. The maximum sorption capacities of Pb(II), Cu(II) and Ni(II) on CNFs in single-metal systems at a pH 5.5±0.2 and 25±1°C were 3.84 (795.65mg/g), 3.21 (204.00mg/g) and 2.67 (156.70mg/g)mmol/g, respectively. In equimolar binary/ternary-metal systems, Pb(II) exhibited greater inhibition of the sorption of Cu(II) and Ni(II), demonstrating the stronger affinity of CNFs for Pb(II). The competitive sorption of heavy metals in ternary-metal systems was predicted quite well by surface complexation modeling derived from single-metal data. According to FTIR, XPS and EXAFS analyses, Pb(II), Cu(II) and Ni(II) were specifically adsorbed on CNFs via covalent bonding. These observations should provide an essential start in simultaneous removal of multiple heavy metals from aquatic environments by CNFs, and open the doorways for the application of CNFs.

  16. Phosphate effects on copper(II) and lead(II) sorption to ferrihydrite

    NASA Astrophysics Data System (ADS)

    Tiberg, Charlotta; Sjöstedt, Carin; Persson, Ingmar; Gustafsson, Jon Petter

    2013-11-01

    Transport of lead(II) and copper(II) ions in soil is affected by the soil phosphorus status. Part of the explanation may be that phosphate increases the adsorption of copper(II) and lead(II) to iron (hydr)oxides in soil, but the details of these interactions are poorly known. Knowledge about such mechanisms is important, for example, in risk assessments of contaminated sites and development of remediation methods. We used a combination of batch experiments, extended X-ray absorption fine structure (EXAFS) spectroscopy and surface complexation modeling with the three-plane CD-MUSIC model to study the effect of phosphate on sorption of copper(II) and lead(II) to ferrihydrite. The aim was to identify the surface complexes formed and to derive constants for the surface complexation reactions. In the batch experiments phosphate greatly enhanced the adsorption of copper(II) and lead(II) to ferrihydrite at pH < 6. The largest effects were seen for lead(II).

  17. Cu(II) and Zn(II) adsorption capacity of three different clay liner materials.

    PubMed

    Musso, T B; Parolo, M E; Pettinari, G; Francisca, F M

    2014-12-15

    Sorption of Cu(II) and Zn(II) on three natural clays meeting the international requirements for use as liners was evaluated by means of batch tests. The purpose of this research was to determine the retention capacities of the clays for metal cations commonly present in urban solid waste leachates. The pH and ionic strength conditions were set at values frequently found in real leachates. The changes observed in the XRD patterns and FTIR spectra upon adsorption can be considered an evidence of clay-metal electrostatic interaction. The Langmuir model was found to best describe the sorption processes, offering maximum sorption capacities from 8.16 to 56.89 mg/g for Cu(II) and from 49.59 to 103.83 mg/g for Zn(II). All samples remove more Zn(II) than Cu(II), which may be related to the different geometry of the hydrated Cu(II) cation. The total amount of metal sorption was strongly influenced by the total specific surface area, the presence of carbonates and the smectite content of the clays. In addition to their known quality as physical barriers, the adsorbed amounts obtained indicate the suitability of the tested clays to contribute to the retardation of Cu(II) and Zn(II) transport through clay liners.

  18. Adsorption character for removal Cu(II) by magnetic Cu(II) ion imprinted composite adsorbent.

    PubMed

    Ren, Yueming; Wei, Xizhu; Zhang, Milin

    2008-10-01

    A novel magnetic Cu(II) ion imprinted composite adsorbent (Cu(II)-MICA) was synthesized, characterized and applied for the selective removal Cu(II) from aqueous solution in the batch system. The adsorption-desorption and selectivity characteristics were investigated. The maximum adsorption occurred at pH 5-6. The equilibrium time was 6.0h, and a pseudo-second-order model could best describe adsorption kinetics. The adsorption equilibrium data fit Langmuir isotherm equation well with a maximum adsorption capacity of 46.25mg/g and Langmuir adsorption equilibrium constant of 0.0956L/mg at 298K. Thermodynamic parameters analysis predicted an exothermic nature of adsorption and a spontaneous and favourable process that could be mainly governed by physisorption mechanism. The relative selectivity coefficients of Cu(II)-MICA for Cu(II)/Zn(II) and Cu(II)/Ni(II) were 2.31, 2.66 times greater than the magnetic non-imprinted composite adsorbent (MNICA). Results suggested that Cu(II)-MICA was a material of efficient, low-cost, convenient separation under magnetic field and could be reused five times with about 14% regeneration loss.

  19. STELLAR POPULATIONS AND THE STAR FORMATION HISTORIES OF LOW SURFACE BRIGHTNESS GALAXIES. II. H II REGIONS

    SciTech Connect

    Schombert, James; McGaugh, Stacy; Maciel, Tamela E-mail: stacy.mcgaugh@case.edu

    2013-08-01

    The luminosities, colors, and H{alpha} emission for 429 H II regions in 54 low surface brightness (LSB) galaxies are presented. While the number of H II regions per galaxy is lower in LSB galaxies compared to star-forming irregulars and spirals, there is no indication that the size or luminosity function of H II regions differs from other galaxy types. The lower number of H II regions per galaxy is consistent with their lower total star formation rates. The fraction of the total L{sub H{alpha}} contributed by H II regions varies from 10% to 90% in LSB galaxies (the rest of the H{alpha} emission being associated with a diffuse component) with no correlation with galaxy stellar or gas mass. Bright H II regions have bluer colors, similar to the trend in spirals; their number and luminosities are consistent with the hypothesis that they are produced by the same H II luminosity function as spirals. Comparison with stellar population models indicates that the brightest H II regions in LSB galaxies range in cluster mass from a few 10{sup 3} M{sub Sun} (e.g., {rho} Oph) to globular-cluster-sized systems (e.g., 30 Dor) and that their ages are consistent with clusters from 2 to 15 Myr old. The faintest H II regions are comparable to those in the LMC powered by a single O or B star. Thus, star formation in LSB galaxies covers the full range of stellar cluster mass.

  20. Determination of circulating levels of insulin-like growth factor II (IGF-II) in swine.

    PubMed

    Buonomo, F C; Grohs, D L; Baile, C A; Campion, D R

    1988-10-01

    A heterologous radioimmunoassay system was developed for the determination of circulating IGF-II concentrations in swine. The assay utilized a monoclonal antibody against human IGF-II (Amano Intl. Ez, VA) and bovine IGF-II (Monsanto Co., MO) as the cold standard and iodinated ligand. Serial dilutions of acid-ethanol extracted normal swine sera resulted in a curve which was parallel to the bovine IGF-II standard curve. Recovery of unlabeled standard added to extracted swine sera was 101%. Neither IGF-I nor insulin were capable of cross-reacting in this assay at levels up to 100-fold excess. Using this assay, serum IGF-II levels were determined to be significantly lower when subnormal growth hormone (GH) levels existed such as in hypophysectomized swine. However, in contrast to serum IGF-I concentrations, supranormal levels of porcine GH (pGH) did not elevate serum IGF-II concentrations after 13 wk of treatment in 25 kg hogs (initial body wt). In addition, serum IGF-II levels were reduced in fasted swine, despite a significant increase in circulating GH concentrations. Thus, although normal concentrations of GH are required for maintenance of physiological levels of IGF-II in swine, the mechanism for stimulation of IGF-II secretion is less GH-dependent than IGF-I.

  1. Radiative lifetimes, branching rations, and absolute transition probabilities in Cr II and Zn II

    NASA Technical Reports Server (NTRS)

    Bergeson, S. D.; Lawler, J. E.

    1993-01-01

    New absolute atomic transition probability measurements are reported for 12 transitions in Cr II and two transitions in Zn II. These transition probabilities are determined by combining branching ratios measured by classical techniques and radiative lifetimes measured by time-resolved laser-induced fluorescence. The measurements are compared with branching fractions, radiative lifetimes, and transition probabilities in the literature. The 206 nm resonance multiplets in Cr II and Zn II are included in this work. These multiplets are very useful in determining the distribution of the elements in the gas versus grain phases in the interstellar medium.

  2. Ion paired chromatography of iron (II,III), nickel (II) and copper (II) as their 4,7-Diphenyl-1,10-phenanthroline chelates.

    PubMed

    Mudasir; Yoshioka, N; Inoue, H

    1997-07-01

    A reversed phase ion-paired chromatographic method that can be used to determine trace amounts of iron (II,III), nickel (II) and copper (II) was developed and applied to the determination of iron (II) and iron (III) levels in natural water. The separation of these metal ions as their 4,7-diphenyl-1,10-phenanthroline (bathophenanthroline) chelates on an Inertsil ODS column was investigated by using acetonitrile-water (80/20, v/v) containing 0.06 M perchloric acid as mobile phase and diode array spectrophotometric detection at 250-650 nm. Chromatographic parameters such as composition of mobile phase and concentration of perchloric acid in mobile phase were optimized. The calibration graphs of iron (II), nickel (II) and copper (II) ions were linear (r > 0.991) in the concentration range 0-0.5, 0-2.0 and 0-4.0 mug ml(-1), respectively. The detection limit of iron (II), nickel (II) and copper (II) were 2.67, 5.42 and 18.2 ng ml(-1) with relative standard deviation (n = 5) of 3.11, 5.81 and 7.16% at a concentration level of 10 ng ml(-1) for iron (II) and nickel (II) and 25 ng ml(-1) for copper (II), respectively. The proposed method was applied to the determination of iron(II) and iron(III) in tap water and sea water samples without any interference from other common metal ions.

  3. Electrochemical studies of DNA interaction and antimicrobial activities of MnII, FeIII, CoII and NiII Schiff base tetraazamacrocyclic complexes

    NASA Astrophysics Data System (ADS)

    Kumar, Anuj; Vashistha, Vinod Kumar; Tevatia, Prashant; Singh, Randhir

    2017-04-01

    Tetraazamacrocyclic complexes of MnII, FeIII, CoII and NiII have been synthesized by template method. These tetraazamacrocycles have been analyzed with various techniques like molar conductance, IR, UV-vis, mass spectral and cyclic voltammetric studies. On the basis of all these studies, octahedral geometry has been assigned to these tetraazamacrocyclic complexes. The DNA binding properties of these macrocyclic complexes have been investigated by electronic absorption spectra, fluorescence spectra, cyclic voltammetric and differential pulse voltammetric studies. The cyclic voltammetric data showed that ipc and ipa were effectively decreased in the presence of calf thymus DNA, which is a strong evidence for the interaction of these macrocyclic complexes with the calf thymus DNA (ct-DNA). The heterogeneous electron transfer rate constant found in the order: KCoII > KNiII > KMnII which indicates that CoII macrocyclic complex has formed a strong intercalated intermediate. The Stern-Volmer quenching constant (KSV) and voltammetric binding constant were found in the order KSV(CoII) > KSV(NiII) > KSV(MnII) and K+(CoII) > K+(NiII) > K+(MnII) which shows that CoII macrocyclic complex exhibits the high interaction affinity towards ct-DNA by the intercalation binding. Biological studies of the macrocyclic complexes compared with the standard drug like Gentamycin, have shown antibacterial activities against E. coli, P. aeruginosa, B. cereus, S. aureus and antifungal activity against C. albicans.

  4. [Angiotensin II receptor antagonists: different or equivalent?].

    PubMed

    Mounier-Vehier, C; Devos, P

    ARA-II: Angiotensin II receptor antagonists (ARA-II) belong to a recent class of antihypertensive drugs whose mechanism of action is similar to converting enzyme inhibitors (CEI). ARA-II are particularly interesting due to the excellent clinical and biological tolerance, similar to placebo, and their antihypertensive efficacy, comparable with classical drug classes. PUBLISHED TRIALS: A meta-analysis, published by Conlin in the American Journal of Hypertension, suggests that ARA-II, specifically losartan, valsartan, irbesartan and candesartan, have an equipotent blood pressure lowering effect. The careful lecture of this meta-analysis however discloses a faulty methodology from which no valid conclusion can be drawn. Since this early publication, several other comparative studies have been published. These multicentric, randomized double-blind studies enrolled a sufficient number of patients and demonstrated a clinical difference between certain ARA-II at usual dosages. CLINICAL PRACTICE: These studies do have an impact on everyday practice. For the practitioner, the goal is to obtain and then maintain a long-term and optimal reduction in the blood pressure level (reduction or prevention of target-organ disorders and cardiovascular complications of high blood pressure). This reduction in the cardiovascular risk will also depend directly on tolerance and compliance to the antihypertensive treatment. This element must also be considered in assessing treatment efficacy, independent of the blood pressure lowering effect. The results of several other studies will be published in 2001-2003. These large-scale studies on ARA-II related morbidity and mortality will be most useful in determining the role of these drugs in different therapeutic strategies compared with other drug classes.

  5. Immobilization of Pb(II), Cd(II) and Ni(II) ions on kaolinite and montmorillonite surfaces from aqueous medium.

    PubMed

    Sen Gupta, Susmita; Bhattacharyya, Krishna G

    2008-04-01

    The present study investigates the immobilization of Pb(II), Cd(II) and Ni(II) on clays (kaolinite and montmorillonite) in aqueous medium through the process of adsorption under a set of variables (concentration of metal ion, amount of clay, pH, time and temperature of interaction). Increasing pH favours the removal of metal ions till they are precipitated as the insoluble hydroxides. The uptake is rapid with maximum adsorption being observed within 180 min for Pb(II) and Ni(II) and 240 min for Cd(II). A number of available models like the Lagergren pseudo first-order kinetics, second-order kinetics, Elovich equation, liquid film diffusion and intra-particle diffusion are utilized to evaluate the kinetics and the mechanism of the immobilization interactions. Two isotherm equations due to Langmuir and Freundlich showed good fits with the experimental data. Kaolinite and montmorillonite have considerable Langmuir monolayer capacity with respect to Pb(II), Cd(II) and Ni(II), the values being in the range of 6.8-11.5mg/g (kaolinite) and 21.1-31.1mg/g (montmorillonite). The Freundlich adsorption capacity follows a similar order. The thermodynamics of the immobilization process indicates the same to be exothermic with Pb(II) and Ni(II), but endothermic with Cd(II). The interactions with Pb(II) and Ni(II) are accompanied by decrease in entropy and Gibbs energy while the endothermic immobilization of Cd(II) is supported by an increase in entropy and an appreciable decrease in Gibbs energy. The results have established good potentiality for kaolinite and montmorillonite to remove heavy metals like Pb(II), Cd(II) and Ni(II) from aqueous medium through adsorption-mediated immobilization.

  6. Selective Hg(II) adsorption from aqueous solutions of Hg(II) and Pb(II) by hydrolyzed acrylamide-grafted PET films.

    PubMed

    Rahman, Nazia; Sato, Nobuhiro; Sugiyama, Masaaki; Hidaka, Yoshiki; Okabe, Hirotaka; Hara, Kazuhiro

    2014-01-01

    Selective Hg(II) adsorption from aqueous solutions of Hg(II) and Pb(II) using hydrolyzed acrylamide (AAm)-grafted polyethylene terephthalate (PET) films was examined to explore the potential reuse of waste PET materials. Selective recovery of Hg(II) from a mixture of soft acids with similar structure, such as Hg(II) and Pb(II), is important to allow the reuse of recovered Hg(II). An adsorbent for selective Hg(II) adsorption was prepared by γ-ray-induced grafting of AAm onto PET films followed by partial hydrolysis through KOH treatment. The adsorption capacity of the AAm-grafted PET films for Hg(II) ions increased from 15 to 70 mg/g after partial hydrolysis because of the reduction of hydrogen bonding between -CONH2 groups and the corresponding improved access of metal ions to the amide groups. The prepared adsorbent was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The absorbent film showed high selectivity for the adsorption of Hg(II) over Pb(II) throughout the entire initial metal concentration range (100-500 mg/L) and pH range (2.2-5.6) studied. The high selectivity is attributed to the ability of Hg(II) ions to form covalent bonds with the amide groups. The calculated selectivity coefficient for the adsorbent binding Hg(II) over Pb(II) was 19.2 at pH 4.5 with an initial metal concentration of 100 mg/L. Selective Hg(II) adsorption equilibrium data followed the Langmuir model and kinetic data were well fitted by a pseudo-second-order equation. The adsorbed Hg(II) and Pb(II) ions were effectively desorbed from the adsorbent film by acid treatment, and the regenerated film showed no marked loss of adsorption capacity upon reuse for selective Hg(II) adsorption.

  7. Luminosity function of [O II] emission-line galaxies in the MassiveBlack-II simulation

    NASA Astrophysics Data System (ADS)

    Park, KwangHo; Di Matteo, Tiziana; Ho, Shirley; Croft, Rupert; Wilkins, Stephen M.; Feng, Yu; Khandai, Nishikanta

    2015-11-01

    We examine the luminosity function (LF) of [O II] emission-line galaxies in the high-resolution cosmological simulation MassiveBlack-II (MBII). From the spectral energy distribution of each galaxy, we select a sub-sample of star-forming galaxies at 0.06 ≤ z ≤ 3.0 using the [O II] emission line luminosity L([O II]). We confirm that the specific star formation rate matches that in the Galaxy And Mass Assembly survey. We show that the [O II] LF at z = 1.0 from the MBII shows good agreement with the LFs from several surveys below L([O II]) = 1043.0 erg s-1 while the low redshifts (z ≤ 0.3) show an excess in the prediction of bright [O II] galaxies, but still displaying a good match with observations below L([O II]) = 1041.6 erg s-1. Based on the validity in reproducing the properties of [O II] galaxies at low redshift (z ≤ 1), we forecast the evolution of the [O II] LF at high redshift (z ≤ 3), which can be tested by upcoming surveys such as the Hobby-Eberly Telescope Dark Energy Experiment and Dark Energy Spectroscopic Instrument. The slopes of the LFs at bright and faint ends range from -3 to -2 showing minima at z = 2. The slope of the bright end evolves approximately as (z + 1)-1 at z ≤ 2 while the faint end evolves as ˜3(z + 1)-1 at 0.6 ≤ z ≤ 2. In addition, a similar analysis is applied for the evolution of [O III] LFs, which is to be explored in the forthcoming survey Wide-Field InfraRed Survey Telescope-Astrophysics Focused Telescope Assets. Finally, we show that the auto-correlation function of [O II] and [O III] emitting galaxies shows a rapid evolution from z = 2 to 1.

  8. Synthesis, physico-chemical studies of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes with some p-substituted acetophenone benzoylhydrazones and their antimicrobial activity.

    PubMed

    Singh, Vinod P; Singh, Shweta; Katiyar, Anshu

    2009-04-01

    Complexes of the type [M(pabh)(H2O)Cl], [M(pcbh)(H2O)Cl] and [M(Hpabh)(H2O)2 (SO4)] where, M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II); Hpabh = p-amino acetophenone benzoyl hydrazone and Hpcbh = p-chloro acetophenone benzoyl hydrazone have been synthesized and characterized with the help of elemental analyses, electrical conductance, magnetic susceptibility measurements, electronic, ESR and IR spectra, thermal (TGA & DTA) and X-ray diffraction studies. Co(II), Ni(II) and Cu(II) chloride complexes are square planar, whereas their sulfate complexes have spin-free octahedral geometry. ESR spectra of Cu(II) complexes with Hpabh are axial and suggest d(x(2)-y(2) as the ground state. The ligand is bidentate bonding through > C = N--and deprotonated enolate group in all the chloro complexes, whereas, >C = N and >C = O groups in all the sulfato complexes. Thermal studies (TGA & DTA) on [Cu(Hpabh)(H2O)2(SO4)] indicate a multistep decomposition pattern, which are both exothermic and endothermic in nature. X-ray powder diffraction parameters for [Co(pabh)(H2O)Cl] and [Ni(Hpabh)(H2O)2(SO4)] correspond to tetragonal and orthorhombic crystal lattices, respectively. The ligands as well as their complexes show a significant antifungal and antibacterial activity. The metal complexes are more active than the ligand.

  9. Dinuclear cadmium(II), zinc(II), and manganese(II), trinuclear nickel(II), and pentanuclear copper(II) complexes with novel macrocyclic and acyclic Schiff-base ligands having enantiopure or racemic camphoric diamine components.

    PubMed

    Jiang, Jue-Chao; Chu, Zhao-Lian; Huang, Wei; Wang, Gang; You, Xiao-Zeng

    2010-07-05

    Four novel [3 + 3] Schiff-base macrocyclic ligands I-IV condensed from 2,6-diformyl-4-substituted phenols (R = CH(3) or Cl) and enantiopure or racemic camphoric diamines have been synthesized and characterized. Metal-ion complexations of these enantiopure and racemic [3 + 3] macrocyclic ligands with different cadmium(II), zinc(II), manganese(II), nickel(II), and copper(II) salts lead to the cleavage of Schiff-base C horizontal lineN double bonds and subsequent ring contraction of the macrocyclic ligands due to the size effects and the spatial restrictions of the coordination geometry of the central metals, the steric hindrance of ligands, and the counterions used. As a result, five [2 + 2] and one [1 + 2] dinuclear cadmium(II) complexes (1-6), two [2 + 2] dinuclear zinc(II) (7 and 8), and two [2 + 2] dinuclear manganese(II) (9 and 10) complexes together with one [1 + 1] trinuclear nickel(II) complex (11) and one [1 + 2] pentanuclear copper(II) complex (12), bearing enantiopure or racemic ligands, different substituent groups in the phenyl rings, and different anionic ligands (Cl(-), Br(-), OAc(-), and SCN(-)), have been obtained in which the chiral carbon atoms in the camphoric backbones are arranged in different ways (RRSS for the enantiopure ligands in 1, 2, 4, 5, and 7-10 and RSRS for the racemic ligands in 3, 6, 11, and 12). The steric hindrance effects of the methyl group bonded to one of the chiral carbon atoms of camphoric diamine units are believed to play important roles in the formation of the acyclic [1 + 1] trinuclear complex 11 and [1 + 2] dinuclear and pentanuclear complexes 6 and 12. In dinuclear cadmium(II), zinc(II), and manganese(II) complexes 1-10, the sequence of separations between the metal centers is consistent with that of the ionic radii shortened from cadmium(II) to manganese(II) to zinc(II) ions. Furthermore, UV-vis, circular dichroism, (1)H NMR, and fluorescence spectra have been used to characterize and compare the structural

  10. Spectroscopic evaluation of Co(II), Ni(II) and Cu(II) complexes derived from thiosemicarbazone and semicarbazone.

    PubMed

    Chandra, Sulekh; Kumar, Anil

    2007-12-31

    Co(II), Ni(II) and Cu(II) complexes were synthesized with thiosemicarbazone (L(1)) and semicarbazone (L(2)) derived from 2-acetyl furan. These complexes were characterized by elemental analysis, molar conductance, magnetic moment, mass, IR, electronic and EPR spectral studies. The molar conductance measurement of the complexes in DMSO corresponds to non-electrolytic nature. All the complexes are of high-spin type. On the basis of different spectral studies six coordinated geometry may be assigned for all the complexes except Co(L)(2)(SO(4)) and Cu(L)(2)(SO(4)) [where L=L(1) and L(2)] which are of five coordinated square pyramidal geometry.

  11. Heterotrimetallic Ru(II)/Pd(II)/Ru(II) complexes: synthesis, crystalstructure, spectral characterization, DFT calculation and antimicrobial study.

    PubMed

    Al-Noaimi, Mousa; Nafady, Ayman; Warad, Ismail; Alshwafy, Rwaida; Husein, Ahmad; Talib, Wamidh H; Hadda, Taibi Ben

    2014-03-25

    New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)2(η(3)-triamine)]Cl (5) (triemine=N(1)-(2-aminoethyl)-1,2-ethanediamine) have been synthesized by reacting [RuCl2(PPh3)3] (1) with one mole equivalent of N(1)-(2-aminoethyl)-1,2-ethanediamine in dichloromethane. Reaction of (2) with half-equivalent of (PhCN)2PdCl2 or Pd(OAc)2 in dichloromethane as a solvent afforded two novel heterotrimetallic Ru(II)-Pd(II)-Ru(II) complexes, [Ru(II)Cl2(PPh3)2(triamine)]2[Pd(II)X2](X=Cl, OAc) (3 and 4), bearing bioactive ligand. The progress of the undertaken reactions was monitored by (31)P{1H} NMR and FTIR. Crystal structure of complex 2 was confirmed by X-ray diffraction. The absorption spectrum of 2 in dichloromethane was modeled by time-dependent density functional theory (TD-DFT). The in vitro antimicrobial studies of complex 2-5 against an array of microorganisms (bacteria and fungi) were conducted. Complexes 3 and 4 exhibit high dual antibacterial and antifungal activity inhibiting microorganisms possibly via hydrolytic pathway which further evidenced by electrochemical analyses. The complexes 3 and 4 show a high inhibitory activity at 200 μg/ml concentration, suggesting that complexes 3 and 4 are two efficient catalytic inhibitor of microorganisms and further, they should be tested against cancer strains.

  12. From Ultracompact to Extended H II Regions

    NASA Astrophysics Data System (ADS)

    Garcia-Segura, Guillermo; Franco, Jose

    1996-09-01

    The dynamical evolution of H II regions and wind-driven bubbles in dense clouds is studied. In particular, we address two different issues: (1) the conditions under which ultracompact H II (UCHII) regions can reach pressure equilibrium with their surrounding medium (and thereby stall their expansion) and (2) the appearance of a powerful dynamic instability in expanding H II regions. At pressure equilibrium, the ionized regions become static, and as long as the ionization sources and the ambient gas densities remain about constant, the resulting UCHII regions are stable and long-lived. The equilibrium sizes and densities, Rs,eq ˜3 X 10-2F⅓48T⅔H II, 4P-⅔7 pc and ni,eq ˜4 × 104P7T-1H II, 4 cm-3 (where Fβ8 is the photoionizing flux in units of 1048 s-11, P7 is the pressure in units of 10-7 dyne cm-2, and TH II,4 is the ion temperature in units of 104 K), are similar to those actually observed in UCHII regions. Similarly, ultra- compact wind-driven bubbles can reach pressure equilibrium, and the resulting final sizes are similar to those of UCHII'S. The same is true for a combined ultracompact structure consisting of an interior wind- driven cavity and an external H II region. For nonmoving stars in a constant-density medium, the lifetimes for all types of ultracompact objects only depend on the stellar lifetimes. For cases with a density gradient, depending on the core size and slope of the density distribution, some regions never reach the static equilibrium condition. A powerful dynamic instability appears when cooling is included in the neutral gas swept up by an H II region or a combined wind-H II region structure. This instability was first studied by Giuliani and is associated with the thin-shell instability described by Vishniac. The internal ionization front exacerbates the growth of the thin-shell instability, creating a rapid shell fragmentation, and our numerical simulations confirm the linear analysis of Giuliani. The fragments tend to merge as

  13. 20 CFR 226.32 - Spouse tier II.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Spouse tier II. 226.32 Section 226.32... Spouse tier II. The spouse tier II benefit is computed as follows: (a) The employee's tier II amount as... before reduction for the railroad retirement family maximum, is multiplied by 45 percent. The spouse...

  14. 20 CFR 226.32 - Spouse tier II.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Spouse tier II. 226.32 Section 226.32... Spouse tier II. The spouse tier II benefit is computed as follows: (a) The employee's tier II amount as... before reduction for the railroad retirement family maximum, is multiplied by 45 percent. The spouse...

  15. 20 CFR 226.32 - Spouse tier II.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Spouse tier II. 226.32 Section 226.32... Spouse tier II. The spouse tier II benefit is computed as follows: (a) The employee's tier II amount as... before reduction for the railroad retirement family maximum, is multiplied by 45 percent. The spouse...

  16. 20 CFR 226.32 - Spouse tier II.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Spouse tier II. 226.32 Section 226.32... Spouse tier II. The spouse tier II benefit is computed as follows: (a) The employee's tier II amount as... before reduction for the railroad retirement family maximum, is multiplied by 45 percent. The spouse...

  17. 20 CFR 226.32 - Spouse tier II.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Spouse tier II. 226.32 Section 226.32... Spouse tier II. The spouse tier II benefit is computed as follows: (a) The employee's tier II amount as... before reduction for the railroad retirement family maximum, is multiplied by 45 percent. The spouse...

  18. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... equations II-1 and II-2. This table contains annual fuel price indices for distillate oil, residual oil... i = MPB where: FPB i = Price of the proposed fuel (distillate oil, residual oil, or natural gas) in... 10 Energy 4 2014-01-01 2014-01-01 false Fuel Price Computation II Appendix II to Part 504...

  19. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and...

  20. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and...

  1. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... example fuel price and inflation indices based on the latest data appearing in the Energy...

  2. Stenogyria - not only in Chiari II malformation.

    PubMed

    Bekiesinska-Figatowska, Monika; Duczkowska, Agnieszka; Brągoszewska, Hanna; Duczkowski, Marek; Mierzewska, Hanna

    2014-12-15

    Stenogyria, meaning multiple small compacted gyri separated by shallow sulci, is reported in the literature in association with Chiari II malformation (CM II) which in turn is reported in association with myelomeningocele (MMC). The authors present five cases of stenogyria (and other abnormalities found in CM II, like callosal hypoplasia/dysplasia, agenesis of the anterior commissure, hypoplasia of the falx cerebri) in children without the history of MMC or any other form of open spinal dysraphism. In these cases stenogyria was associated with Chiari I malformation, rhombencephalosynapsis and spina bifida. Stenogyria, which is not a true neuronal migration disorder, should not be mistaken for polymicrogyria which is also present in CM II. It is histologically different from polymicrogyria because the cortex is normally organized. Also on MRI, the general sulcal pattern is preserved in stenogyria, while it is completely distorted in polymicrogyria. The authors conclude that features traditionally attributed to CM II, like stenogyria, occur not only in the population of patients with MMC as opposed to the widely accepted theory.

  3. THE ARECIBO H II REGION DISCOVERY SURVEY

    SciTech Connect

    Bania, T. M.; Anderson, L. D.; Balser, Dana S.

    2012-11-10

    We report the detection of radio recombination line (RRL) emission using the Arecibo Observatory at X band (9 GHz, 3 cm) from 37 previously unknown H II regions in the Galactic zone 66 Degree-Sign {>=} l {>=} 31 Degree-Sign and | b | {<=} 1 Degree-Sign . This Arecibo H II Region Discovery Survey (Arecibo HRDS) is a continuation of the Green Bank Telescope (GBT) HRDS. The targets for the Arecibo HRDS have spatially coincident 24 {mu}m and 20 cm emission of a similar angular morphology and extent. To take advantage of Arecibo's sensitivity and small beam size, sources in this sample are fainter, smaller in angle, or in more crowded fields compared to those of the GBT HRDS. These Arecibo nebulae are some of the faintest H II regions ever detected in RRL emission. Our detection rate is 58%, which is low compared to the 95% detection rate for GBT HRDS targets. We derive kinematic distances to 23 of the Arecibo HRDS detections. Four nebulae have negative local standard of rest velocities and are thus unambiguously in the outer Galaxy. The remaining sources are at the tangent-point distance or farther. We identify a large, diffuse H II region complex that has an associated H I and {sup 13}CO shell. The {approx}90 pc diameter of the G52L nebula in this complex may be the largest Galactic H II region known, and yet it has escaped previous detection.

  4. Star formation in H II galaxies

    NASA Astrophysics Data System (ADS)

    Torres-Campos, A.; Díaz, A. I.; Terlevich, E.; Rosa-González, D.; Telles, E.; Terlevich, R.

    2013-05-01

    H II galaxies integrated properties have been widely studied. However, little is known about the individual H II regions and their photoionizing stellar clusters. To broaden our knowledge on star formation in low mass star-forming galaxies (like H II galaxies) it is necessary to answer questions like: How does the star formation distributes along the galaxy? Is it possible for them to form super stellar clusters? How does the star formation history on them looks like? To answer those questions the goal of this thesis work is to map (at tens of parsecs resolution) the recent star formation in six H II galaxies with extremely young star-forming bursts (Rosa-González et al. 2007, ApJ, 654, 226). The preliminary results obtained have allowed us to develop a catalog of H II regions (identified for the first time) in these galaxies and the characterization of the young stellar clusters responsible for their photoionization using POPSTAR (Mollá, García-Vargas, & Bressan 2009, MNRAS, 398, 451) stellar populations models.

  5. Photosystem II: the engine of life.

    PubMed

    Barber, James

    2003-02-01

    Photosystem II (PS II) is a multisubunit membrane protein complex, which uses light energy to oxidize water and reduce plastoquinone. High-resolution electron cryomicroscopy and X-ray crystallography are revealing the structure of this important molecular machine. Both approaches have contributed to our understanding of the organization of the transmembrane helices of higher plant and cyanobacterial PS II and both indicate that PS II normally functions as a dimer. However the high-resolution electron density maps derived from X-ray crystallography currently at 3.7/3.8 A, have allowed assignments to be made to the redox active cofactors involved in the light-driven water-plastoquinone oxidoreductase activity and to the chlorophyll molecules that absorb and transfer energy to the reaction centre. In particular the X-ray work has identified density that can accommodate the four manganese atoms which catalyse the water-oxidation process. The Mn cluster is located at the lumenal surface of the DI protein and approximately 7 A from the redox active tyrosine residue (YZ) which acts an electron/proton transfer link to the primary oxidant P680.+. The lower resolution electron microscopy studies, however, are providing structural models of larger PS II supercomplexes that are ideal frameworks in which to incorporate the X-ray derived structures.

  6. COSMIC DUST IN Mg II ABSORBERS

    SciTech Connect

    Menard, Brice; Fukugita, Masataka

    2012-08-01

    Mg II absorbers induce reddening on background quasars. We measure this effect and infer the cosmic density of dust residing in these systems to be {Omega} Almost-Equal-To 2 Multiplication-Sign 10{sup -6}, in units of the critical density of the universe, which is comparable to the amount of dust found in galactic disks or about half the amount inferred to exist outside galaxies. We also estimate the neutral hydrogen abundance in Mg II clouds to be {Omega} Almost-Equal-To 1.5 Multiplication-Sign 10{sup -4}, which is approximately 5% of hydrogen in stars in galaxies. This implies a dust-to-gas mass ratio for Mg II clouds of about 1/100, which is similar to the value for normal galaxies. This would support the hypothesis of the outflow origin of Mg II clouds, which are intrinsically devoid of stars and hence have no sources of dust. Considerations of the dust abundance imply that the presence of Mg II absorbers around galaxies lasts effectively for a few Gyr. High-redshift absorbers allow us to measure the rest-frame extinction curve to 900 A, at which the absorption by the Lyman edge dominates over scattering by dust in the extinction opacity.

  7. Mesospheric ozone measurements by SAGE II

    NASA Technical Reports Server (NTRS)

    Chu, D. A.; Cunnold, D. M.

    1994-01-01

    SAGE II observations of ozone at sunrise and sunset (solar zenith angle = 90 deg) at approximately the same tropical latitude and on the same day exhibit larger concentrations at sunrise than at sunset between 55 and 65 km. Because of the rapid conversion between atomic oxygen and ozone, the onion-peeling scheme used in SAGE II retrievals, which is based on an assumption of constant ozone, is invalid. A one-dimensional photochemical model is used to simulate the diurnal variation of ozone particularly within the solar zenith angle of 80 deg - 100 deg. This model indicates that the retrieved SAGE II sunrise and sunset ozone values are both overestimated. The Chapman reactions produce an adequate simulation of the ozone sunrise/sunset ratio only below 60 km, while above 60 km this ratio is highly affected by the odd oxygen loss due to odd hydrogen reactions, particularly OH. The SAGE II ozone measurements are in excellent agreement with model results to which an onion peeling procedure is applied. The SAGE II ozone observations provide information on the mesospheric chemistry not only through the ozone profile averages but also from the sunrise/sunset ratio.

  8. Belle-II Experiment Network Requirements

    SciTech Connect

    Asner, David; Bell, Greg; Carlson, Tim; Cowley, David; Dart, Eli; Erwin, Brock; Godang, Romulus; Hara, Takanori; Johnson, Jerry; Johnson, Ron; Johnston, Bill; Dam, Kerstin Kleese-van; Kaneko, Toshiaki; Kubota, Yoshihiro; Kuhr, Thomas; McCoy, John; Miyake, Hideki; Monga, Inder; Nakamura, Motonori; Piilonen, Leo; Pordes, Ruth; Ray, Douglas; Russell, Richard; Schram, Malachi; Schroeder, Jim; Sevior, Martin; Singh, Surya; Suzuki, Soh; Sasaki, Takashi; Williams, Jim

    2013-05-28

    The Belle experiment, part of a broad-based search for new physics, is a collaboration of ~400 physicists from 55 institutions across four continents. The Belle detector is located at the KEKB accelerator in Tsukuba, Japan. The Belle detector was operated at the asymmetric electron-positron collider KEKB from 1999-2010. The detector accumulated more than 1 ab-1 of integrated luminosity, corresponding to more than 2 PB of data near 10 GeV center-of-mass energy. Recently, KEK has initiated a $400 million accelerator upgrade to be called SuperKEKB, designed to produce instantaneous and integrated luminosity two orders of magnitude greater than KEKB. The new international collaboration at SuperKEKB is called Belle II. The first data from Belle II/SuperKEKB is expected in 2015. In October 2012, senior members of the Belle-II collaboration gathered at PNNL to discuss the computing and neworking requirements of the Belle-II experiment with ESnet staff and other computing and networking experts. The day-and-a-half-long workshop characterized the instruments and facilities used in the experiment, the process of science for Belle-II, and the computing and networking equipment and configuration requirements to realize the full scientific potential of the collaboration's work.

  9. Centrifuge workers study. Phase II, completion report

    SciTech Connect

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom.

  10. PIP-II Status and Strategy

    SciTech Connect

    Holmes, Stephen; Derwent, Paul; Lebedev, Valeri; Mishra, Shekhar; Mitchell, Donald; Yakovlev, Vyacheslav P.

    2015-06-01

    Proton Improvement Plan-II (PIP-II) is the centerpiece of Fermilab's plan for upgrading the accelerator complex to establish the leading facility in the world for particle physics research based on intense proton beams. PIP-II has been developed to provide 1.2 MW of proton beam power at the start of operations of the Long Baseline Neutrino Facility (LBNF), while simultaneously providing a platform for eventual extension of LBNE beam power to >2MW and enabling future initiatives in rare processes research based on high duty factor/higher beam power operations. PIP-II is based on the construction of a new 800 MeV superconducting linac, augmented by improvements to the existing Booster, Recycler, and Main Injector complex. PIP-II is currently in the development stage with an R&D program underway targeting the front end and superconducting RF acceleration technologies. This paper will describe the status of the PIPII conceptual development, the associated technology R&D programs, and the strategy for project implementation.

  11. Summary of CPAS Gen II Parachute Analysis

    NASA Technical Reports Server (NTRS)

    Morris, Aaron L.; Bledsoe, Kristin J.; Fraire, Usbaldo, Jr.; Moore, James W.; Olson, Leah M.; Ray, Eric

    2011-01-01

    The Orion spacecraft is currently under development by NASA and Lockheed Martin. Like Apollo, Orion will use a series of parachutes to slow its descent and splashdown safely. The Orion parachute system, known as the CEV Parachute Assembly System (CPAS), is being designed by NASA, the Engineering and Science Contract Group (ESCG), and Airborne Systems. The first generation (Gen I) of CPAS testing consisted of thirteen tests and was executed in the 2007-2008 timeframe. The Gen I tests provided an initial understanding of the CPAS parachutes. Knowledge gained from Gen I testing was used to plan the second generation of testing (Gen II). Gen II consisted of six tests: three singleparachute tests, designated as Main Development Tests, and three Cluster Development Tests. Gen II required a more thorough investigation into parachute performance than Gen I. Higher fidelity instrumentation, enhanced analysis methods and tools, and advanced test techniques were developed. The results of the Gen II test series are being incorporated into the CPAS design. Further testing and refinement of the design and model of parachute performance will occur during the upcoming third generation of testing (Gen III). This paper will provide an overview of the developments in CPAS analysis following the end of Gen I, including descriptions of new tools and techniques as well as overviews of the Gen II tests.

  12. 30 CFR Appendix II to Subpart D of... - Appendix II to Subpart D of Part 18

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACCESSORIES Machines Assembled With Certified or Explosion-Proof Components, Field Modifications of Approved Machines, and Permits To Use Experimental Equipment Pt. 18, Subpt. D, App. II Appendix II to Subpart D of Part 18 LIST OF FIGURES Figure No. Title 1 Typical layout drawing of a machine. 2 Sample bill...

  13. Trident II (D-5) Sea Launched Ballistic Missile UGM 133A (Trident II Missile)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-178 Trident II (D-5) Sea-Launched Ballistic Missile UGM 133A (Trident II Missile) As of FY...Executive Officer PM - Program Manager POE - Program Office Estimate RDT&E - Research, Development, Test, and Evaluation SAR - Selected Acquisition

  14. Synthesis, characterization, and photoactivated DNA cleavage by copper (II)/cobalt (II) mediated macrocyclic complexes.

    PubMed

    Naik, H R Prakash; Naik, H S Bhojya; Aravinda, T; Lamani, D S

    2010-01-01

    We report the synthesis of new photonuclease consisting of two Co(II)/Cu(II) complexes of macrocyclic fused quinoline. Metal complexes are [MLX(2)], type where M = Co(II) (5), Cu(II) (6), and X = Cl, and are well characterized by elemental analysis, Fourier transform infrared spectroscopy, (1)H-NMR and electronic spectra. We have shown that photocleavage of plasmid DNA is markedly enhanced when this ligand is irradiated in the presence of Cu(II), and more so than that of cobalt. The chemistry of ternary and binary Co(II) complexes showing efficient light induced (360 nm) DNA cleavage activity is summarized. The role of the metal in photoinduced DNA cleavage reactions is explored by designing complex molecules having macrocyclic structure. The mechanistic pathways are found to be concentration dependent on Co(II)/Cu(II) complexes and the photoexcitation energy photoredox chemistry. Highly effective DNA cleavage ability of 6 is attributed to the effective cooperation of the metal moiety.

  15. On Cu(II) Cu(II) distance measurements using pulsed electron electron double resonance

    NASA Astrophysics Data System (ADS)

    Yang, Zhongyu; Becker, James; Saxena, Sunil

    2007-10-01

    The effects of orientational selectivity on the 4-pulse electron electron double resonance (PELDOR) ESR spectra of coupled Cu(II)-Cu(II) spins are presented. The data were collected at four magnetic fields on a poly-proline peptide containing two Cu(II) centers. The Cu(II)-PELDOR spectra of this peptide do not change appreciably with magnetic field at X-band. The data were analyzed by adapting the theory of Maryasov, Tsvetkov, and Raap [A.G. Maryasov, Y.D. Tsvetkov, J. Raap, Weakly coupled radical pairs in solids:ELDOR in ESE structure studies, Appl. Magn. Reson. 14 (1998) 101-113]. Simulations indicate that orientational effects are important for Cu(II)-PELDOR. Based on simulations, the field-independence of the PELDOR data for this peptide is likely due to two effects. First, for this peptide, the Cu(II) g-tensor(s) are in a very specific orientation with respect to the interspin vector. Second, the flexibility of the peptide washes out the orientation effects. These effects reduce the suitability of the poly-proline based peptide as a good model system to experimentally probe orientational effects in such experiments. An average Cu(II)-Cu(II) distance of 2.1-2.2 nm was determined, which is consistent with earlier double quantum coherence ESR results.

  16. Nickel(II) and copper(II) complexes with humic acid anions and their derivatives

    SciTech Connect

    Ryabova, I.N.

    2008-01-15

    Complexation of Ni(II) and Cu(II) in aqueous solutions with anions of humic acids, extracted from naturally oxidized coal, and with their hydroxymethyl derivatives is studied spectrophotometrically and potentiometrically. The complexation stoichiometry and the stability constants of the complexes are determined.

  17. 30 CFR Appendix II to Subpart D of... - Appendix II to Subpart D of Part 18

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ACCESSORIES Machines Assembled With Certified or Explosion-Proof Components, Field Modifications of Approved Machines, and Permits To Use Experimental Equipment Pt. 18, Subpt. D, App. II Appendix II to Subpart D of Part 18 LIST OF FIGURES Figure No. Title 1 Typical layout drawing of a machine. 2 Sample bill...

  18. The vibrational spectra of the Ni(II) and Cu(II) complexes with oxamic hydrazide

    NASA Astrophysics Data System (ADS)

    Quaeyhaegens, Frank; Hofmans, Hendrik; Desseyn, H. O.

    The infrared-, Raman- and u.v./vis spectra as well as the thermal analysis ofthe Ni(II)and Cu(II) complexes with oxamic hydrazide (H 2NCOCONHNH 2) are discussed. We assume 2/1 planar complexes and a coordination via the four amide nitrogen atoms as visualised in Fig. 1.

  19. Employability Planning Process. STIP II (Skill Training Improvement Programs Round II).

    ERIC Educational Resources Information Center

    Los Angeles Community Coll. District, CA.

    Four reports are presented detailing procedures for improving the employability of students enrolled in the Los Angeles Community College District's Skill Training Improvement Programs (STIP II). Each report was submitted by one of the four STIP II programs: Los Angeles Southwest College's program for computer programming; the programs for…

  20. Biosorption of cadmium (II) and lead (II) from aqueous solutions using mushrooms: a comparative study.

    PubMed

    Vimala, R; Das, Nilanjana

    2009-08-30

    Sorption capacity of oyster mushroom (Pleurotus platypus), button mushroom (Agaricus bisporus) and milky mushroom (Calocybe indica) were evaluated on biosorption of heavy metals, viz. cadmium (II) and lead (II) from aqueous solutions. The optimum sorption conditions were studied for each metal separately. The desired pH of the aqueous solution was found to be 6.0 for the removal of cadmium (II) and 5.0 for removal of lead (II) for all the mushrooms. The percent removal of both the metals was found to increase with the increase in biosorbent dosage and contact time. The fitness of the biosorption data for Langmuir and Freundlich adsorption models was investigated. It was found that biosorption of cadmium (II) and lead (II) ions onto the biomass of the three mushrooms were better suitable to Langmuir than Freundlich adsorption model. P. platypus showed the highest metal uptake potential for cadmium (q(max) 34.96 mg/g) whereas A. bisporus exhibited maximum potential for lead (q(max) 33.78 mg/g). Milky mushroom showed the lowest metal uptake capacity for both the metals. The present data confirms that mushrooms may be used as efficient biosorbent for the removal of cadmium (II) and lead (II) ions from aqueous solution.

  1. Type II achondrogenesis-hypochondrogenesis: identification of abnormal type II collagen.

    PubMed

    Godfrey, M; Hollister, D W

    1988-12-01

    We have extended the study of a mild case of type II achondrogenesis-hypochondrogenesis to include biochemical analyses of cartilage, bone, and the collagens produced by dermal fibroblasts. Type I collagen extracted from bone and types I and III collagen produced by dermal fibroblasts were normal, as was the hexosamine ratio of cartilage proteoglycans. Hyaline cartilage, however, contained approximately equal amounts of types I and II collagen and decreased amounts of type XI collagen. Unlike the normal SDS-PAGE mobility. Two-dimensional SDS-PAGE revealed extensive overmodification of all type II cyanogen bromide peptides in a pattern consistent with heterozygosity for an abnormal pro alpha 1(II) chain which impaired the assembly and/or folding of type II collagen. This interpretation implies that dominant mutations of the COL2A1 gene may cause type II achondrogenesis-hypochondrogenesis. More generally, emerging data implicating defects of type II collagen in the type II achondrogenesis-hypochondrogenesis-spondyloepiphyseal dysplasia congenita spectrum and in the Kniest-Stickler syndrome spectrum suggest that diverse mutations of this gene may be associated with widely differing phenotypic outcome.

  2. Better prognostic marker in ICU - APACHE II, SOFA or SAP II!

    PubMed Central

    Naqvi, Iftikhar Haider; Mahmood, Khalid; Ziaullaha, Syed; Kashif, Syed Mohammad; Sharif, Asim

    2016-01-01

    Objectives: This study was designed to determine the comparative efficacy of different scoring system in assessing the prognosis of critically ill patients. Methods: This was a retrospective study conducted in medical intensive care unit (MICU) and high dependency unit (HDU) Medical Unit III, Civil Hospital, from April 2012 to August 2012. All patients over age 16 years old who have fulfilled the criteria for MICU admission were included. Predictive mortality of APACHE II, SAP II and SOFA were calculated. Calibration and discrimination were used for validity of each scoring model. Results: A total of 96 patients with equal gender distribution were enrolled. The average APACHE II score in non-survivors (27.97+8.53) was higher than survivors (15.82+8.79) with statistically significant p value (<0.001). The average SOFA score in non-survivors (9.68+4.88) was higher than survivors (5.63+3.63) with statistically significant p value (<0.001). SAP II average score in non-survivors (53.71+19.05) was higher than survivors (30.18+16.24) with statistically significant p value (<0.001). Conclusion: All three tested scoring models (APACHE II, SAP II and SOFA) would be accurate enough for a general description of our ICU patients. APACHE II has showed better calibration and discrimination power than SAP II and SOFA. PMID:27882011

  3. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    SciTech Connect

    2010-12-17

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  4. Light scattering of human skin: a comparison between zinc (II)-phthalocyanine and photofrin II.

    PubMed

    Ochsner, M

    1996-01-01

    Zinc(II)-phthalocyanine is the active component of the liposomal formulation CGP 55847 which showed a highly activity in photodynamic therapy studies on a variety of animal tumours (K. Schieweck et al., SPIE Conf. Proc., 2078 (1994) 107-118). The photophysical properties of zinc(II)-phthalocyanine have been studied in detail and compared with those of Photofrin II(R), the only sensitizing agent approved so far for Phase III and IV clinical trials (M. Ochsner-Bruderer, Inaugural Dissertation, University of Basle, 1994). As will be shown in a series of papers, the main photophysical properties of zinc(II)-phthalocyanine are significantly better than those of Photofrin II(R) (M. Ochsner-Bruderer, Inaugural Dissertation, University of Basle, 1994). In this paper we especially consider the effect of the absorption wavelength on the penetration of light into the human skin. The results clearly show that the longer absorption wavelength of zinc(II)-phthalocyanine causes a deeper penetration of light into the human skin as compared with Photofrin II(R). In addition to this, the higher extinction coefficient (epsilon S) lowers the zinc(II)-phthalocyanine dose required to induce a tumour necrosis.

  5. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    ScienceCinema

    None

    2016-07-12

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  6. Synthesis, characterization and cyclic voltammetric study of copper(II) and nickel(II) polymer chelates.

    PubMed

    Azmeera, Venkanna; Rastogi, Pankaj Kumar; Adhikary, Pubali; Ganesan, Vellaichamy; Krishnamoorthi, S

    2014-09-22

    Graft copolymers based on dextran (Dx) and 2-acrylamido-2-methyl-1-propane sulphonic acid (AMPS) were synthesized by free radical initiated solution polymerization technique using ceric ammonium nitrate as initiator. These graft copolymers were used to prepare Cu(II) and Ni(II) chelates by reactions with Cu(II) and Ni(II) metal ions respectively. Graft copolymer and metal chelates were characterized by elemental analysis, intrinsic viscosity, FT-IR, scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA) and powder X-ray diffraction (XRD). Elemental analysis, intrinsic viscosity and FT-IR studies revealed the incorporation of metal ions to form metal chelates. SEM studies showed the change in morphology due to metal incorporation. From AFM studies it was observed that there was increase in Root mean square (RMS) roughness values in case of metal complexes. Metal chelates were observed to be thermally more stable than graft copolymer from TGA. UV-vis spectroscopy study revealed increase in absorbance values and cyclic voltammetric (CV) studies showed more than tenfold increase in redox current due to formation of Cu(II) and Ni(II) metal chelates. The binding constants of each complex determined by using UV-visible spectroscopy revealed that Cu(II) has more binding ability than Ni(II).

  7. Type II supernovae as probes of environment metallicity: observations of host H II regions

    NASA Astrophysics Data System (ADS)

    Anderson, J. P.; Gutiérrez, C. P.; Dessart, L.; Hamuy, M.; Galbany, L.; Morrell, N. I.; Stritzinger, M. D.; Phillips, M. M.; Folatelli, G.; Boffin, H. M. J.; de Jaeger, T.; Kuncarayakti, H.; Prieto, J. L.

    2016-05-01

    Context. Spectral modelling of type II supernova atmospheres indicates a clear dependence of metal line strengths on progenitor metallicity. This dependence motivates further work to evaluate the accuracy with which these supernovae can be used as environment metallicity indicators. Aims: To assess this accuracy we present a sample of type II supernova host H ii-region spectroscopy, from which environment oxygen abundances have been derived. These environment abundances are compared to the observed strength of metal lines in supernova spectra. Methods: Combining our sample with measurements from the literature, we present oxygen abundances of 119 host H ii regions by extracting emission line fluxes and using abundance diagnostics. These abundances are then compared to equivalent widths of Fe ii 5018 Å at various time and colour epochs. Results: Our distribution of inferred type II supernova host H ii-region abundances has a range of ~0.6 dex. We confirm the dearth of type II supernovae exploding at metallicities lower than those found (on average) in the Large Magellanic Cloud. The equivalent width of Fe ii 5018 Å at 50 days post-explosion shows a statistically significant correlation with host H ii-region oxygen abundance. The strength of this correlation increases if one excludes abundance measurements derived far from supernova explosion sites. The correlation significance also increases if we only analyse a "gold" IIP sample, and if a colour epoch is used in place of time. In addition, no evidence is found of a correlation between progenitor metallicity and supernova light-curve or spectral properties - except for that stated above with respect to Fe ii 5018 Å equivalent widths - suggesting progenitor metallicity is not a driving factor in producing the diversity that is observed in our sample. Conclusions: This study provides observational evidence of the usefulness of type II supernovae as metallicity indicators. We finish with a discussion of the

  8. Morphological Properties of Slender Ca ii H Fibrils Observed by Sunrise II

    NASA Astrophysics Data System (ADS)

    Gafeira, R.; Lagg, A.; Solanki, S. K.; Jafarzadeh, S.; van Noort, M.; Barthol, P.; Blanco Rodríguez, J.; del Toro Iniesta, J. C.; Gandorfer, A.; Gizon, L.; Hirzberger, J.; Knölker, M.; Orozco Suárez, D.; Riethmüller, T. L.; Schmidt, W.

    2017-03-01

    We use seeing-free high spatial resolution Ca ii H data obtained by the Sunrise observatory to determine properties of slender fibrils in the lower solar chromosphere. In this work we use intensity images taken with the SuFI instrument in the Ca ii H line during the second scientific flight of the Sunrise observatory to identify and track elongated bright structures. After identification, we analyze theses structures to extract their morphological properties. We identify 598 slender Ca ii H fibrils (SCFs) with an average width of around 180 km, length between 500 and 4000 km, average lifetime of ≈400 s, and average curvature of 0.002 arcsec‑1. The maximum lifetime of the SCFs within our time series of 57 minutes is ≈2000 s. We discuss similarities and differences of the SCFs with other small-scale, chromospheric structures such as spicules of type I and II, or Ca ii K fibrils.

  9. [Anti Shiga-like toxin II(SLT-II) humanized monoclonal antibody].

    PubMed

    Matsumoto, Yoh-ichi

    2002-03-01

    Anti-Shiga-Like Toxin II(SLT-II) Humanized Monoclonal Antibody(TMA-15) was constructed from Mouse Monoclonal Antibody(MuVTm1.1) recognizing the same antigen using recombinant and CDR grafting technology. TMA-15 had almost the same affinity to SLT-II as MuVTm1.1 and showed the good protective activity of mice challenged either with SLT-II or with SLT-II secreting Shiga-like Toxin producing E. coli(STEC). TMA-15 showed no acute toxicity to monkeys and no cross-reactivity to human tissues in pre-clinical safety studies. From the preliminary results of Phase 1 clinical trial using healthy adult volunteers, doses up to planned maximum dose were well tolerated and TMA-15 showed long half life in blood almost comparable to gamma globulin preparations. Therefore, TMA-15 is expected to show clinical efficacy in coming clinical trial using pediatric STEC patients.

  10. Validation of the Sexual Assault Symptom Scale II (SASS II) using a panel research design.

    PubMed

    Ruch, Libby O; Wang, Chang-Hwai

    2006-11-01

    To examine the utility of a self-report scale of sexual assault trauma, 223 female victims were interviewed with the 43-item Sexual Assault Symptom Scale II (SASS II) at 1, 3, 7, 11, and 15 months postassault. Factor analyses using principal-components extraction with an oblimin rotation yielded 7 common factors with 31 items. The internal consistency was high for 4 factors and moderate for 2 factors. The multitrait-multimethod matrix, correlating the factor subscale scores of self-reported trauma and clinical assessment ratings, demonstrated both convergent and discriminant validity, indicating that the SASS II has construct validity. Correlations between the SASS II subscales and the intrusion subscale of the Impact of Events Scale also indicated the convergent and discriminant validity of the SASS II. Significant positive correlations between current and prior trauma levels further evidence the validity of the SASS.

  11. XAFS studies of Pb(II)-chloro and Hg(II)-chloro ternary complexes on goethite

    USGS Publications Warehouse

    Bargar, J.R.; Persson, Petra; Brown, Gordon E.

    1997-01-01

    EXAFS spectroscopy was used to study Pb(II) and Hg(II) adsorption complexes on goethite (??-FeOOH) in the presence of Cl-. At pH 7, the dominant Pb(II) species are bonded to edges of FeO6 octahedra and are similar to complexes that occur in the absence of Cl-. At pH ??? 6, Pb(II)-chloro ternary complexes predominate and are bonded to corners of FeO6 octahedra. At pH 6.5, linear Hg(OH)Cl ternary complexes predominate that are bonded to goethite through surface oxygens in a bent Hg-O-Fe geometry. In the absence of Cl-, the Hg(II) surface complexes retain this basic geometry, but an OH group replaces the chloride ion in the first coordination shell.

  12. Spectroscopic and thermal degradation behavior of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes with thiopental sodium anesthesia drug

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.

    2013-04-01

    A new series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized with thiopental sodium anesthesia drug. The elemental analyses of the complexes are confined to stoichiometry of the formulas [M(TPL)3]ṡnH2O (M = Cr(III) or Fe(III); n = 6 or 5), [M(TPL)2(H2O)2]ṡnH2O (M = Mn(II), Co(II) or Ni(II); n = 0 or 4), and [M(TPL)2] (M = Cu(II) or Zn(II); n = 2 or 0) respectively, where TPL is thiopental chelating agent. Structures have been discussed and suggested upon elemental analyses, infrared, Raman, electronic, electron spin resonance, 1H NMR spectral data and magnetic studies. The X-ray powder diffraction (XRD) was performed of metal complexes. The XRD patterns indicate crystalline nature for the complexes. The measured low molar conductance values in dimethylsulfoxide indicate that the complexes are non-electrolyte nature. Spectroscopic discussion refer that coordination take place through three types: Cdbnd N (pyrimidine moiety) nitrogen and C2sbnd S (2-thiolate group) for Cr(III), Mn(II) and Fe(III), C6dbnd O (amido group) oxygen and C2sbnd S (2-thiolate group) for Co(II) and Ni(II), and Cu(II) and Zn(II) ions coordinated via Cdbnd N (pyrimidine moiety) nitrogen, C2dbnd S (2-thiolate group) and C6dbnd O (amido group) oxygen, respectively. The thermal behavior (TG/DTG/DTA) of the complexes was studied and kinetic parameters were determined by Horowitz-Metzger and Coats-Redfern methods. The thiopental and its complexes have been screened for their antimicrobial (G+ and G-) bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa) and fungi (Aspergillus flavus and Candida albicans) activities by minimum inhibitory concentration (MIC) method.

  13. ORION II bus demonstration. Demonstration report (Final)

    SciTech Connect

    Shanley, J.

    1989-02-01

    The Central New York Regional Transportation Authority conducted an 18-month demonstration to determine how the ORION II bus operates in actual service. The ORION II vehicle is a small low floor, accessible heavy duty, diesel-powered transit bus designed to meet the needs of the elderly and handicapped. It has the capacity to seat 26 passengers with 4 wheelchair lockdowns. Side and rear doors are equipped with electrically powered ramps. Eight Thomas vehicles (22-foot, 11,500 lbs, wheelchair equipped, gasoline fueled) were also tested during the demonstration period. Operations (fuel and oil usage) and maintenance (scheduled and unscheduled) data were collected and charted-out in the report as well as driver, passenger, and maintenance surveys. This report provides descriptions, photographs, and comparison charts of both the diesel-fueled ORION II transit bus and the gasoline-fueled Thomas vehicles along with the demonstration test plan, evaluations, conclusions, and survey results.

  14. SHIELD II: WSRT HI Spectral Line Observations

    NASA Astrophysics Data System (ADS)

    Gordon, Alex Jonah Robert; Cannon, John M.; Adams, Elizabeth A.; SHIELD II Team

    2016-01-01

    The "Survey of HI in Extremely Low-mass Dwarfs II" ("SHIELD II") is a multiwavelength, legacy-class observational campaign that is facilitating the study of both internal and global evolutionary processes in low-mass dwarf galaxies discovered by the Arecibo Legacy Fast ALFA (ALFALFA) survey. We present new results from WSRT HI spectral line observations of 22 galaxies in the SHIELD II sample. We explore the morphology and kinematics by comparing images of the HI surface densities and the intensity weighted velocity fields with optical images from HST, SDSS, and WIYN. In most cases the HI and stellar populations are cospatial; projected rotation velocities range from less than 10 km/s to roughly 30 km/s.Support for this work was provided by NSF grant AST-1211683 to JMC at Macalester College, and by NASA through grant GO-13750 from the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS5-26555.

  15. TRUPACT-II residue pipe payload container

    SciTech Connect

    Geinitz, R.; Gregory, P.

    1995-06-01

    This paper summarizes the project to develop, test and certify a new payload container for the TRUPACT-II, a Type B packaging for the shipment of transuranic waste. The new payload container will provide segregation of plutonium waste materials within the TRUPACT-II. This segregation of fissile contents will support a new criticality safety analysis that may allow an increase in the TRUPACT-II Pu-239 Fissile Gram Equivalent (FGE) limit from 325 grams to 2800 grams. The need for this project was brought about by the end of the Cold War and the resulting shift in value of plutonium residues from providing recoverable Defense Program material to being considered disposable waste. This paper will not cover many of the details of the project but will instead aim to provide a general picture of all the project activities.

  16. Type II seesaw dominance in SO(10)

    SciTech Connect

    Melfo, Alejandra; Ramirez, Alba; Senjanovic, Goran

    2010-10-01

    Grand unified theories where the neutrino mass is given by type II seesaw have the potential to provide interesting connections between the neutrino and charged fermion sectors. We explore the possibility of having a dominant type II seesaw contribution in supersymmetric SO(10). We show that this can be achieved in the model where symmetry breaking is triggered by 54 and 45 dimensional representations, without the need for additional fields other than those already required to have a realistic charged fermion mass spectrum. Physical consequences, such as the implementation of the Bajc, Senjanovic, and Vissani mechanism, the possibility of the fields responsible for type II seesaw dominance being messengers of supersymmetry breaking, and the realization of baryo and leptogenesis in these theories, are discussed.

  17. SHIELD II: VLA HI Spectral Line Observations

    NASA Astrophysics Data System (ADS)

    Lee, Eojin; Cannon, John M.; McNichols, Andrew; Teich, Yaron; SHIELD II Team

    2016-01-01

    The "Survey of HI in Extremely Low-mass Dwarfs II" ("SHIELD II") is a multiwavelength, legacy-class observational campaign that is facilitating the study of both internal and global evolutionary processes in low-mass dwarf galaxies discovered by the Arecibo Legacy Fast ALFA (ALFALFA) survey. We present new results from low-resolution D-configuration VLA HI spectral line observations of 6 galaxies in the SHIELD II sample. We explore the morphology and kinematics by comparing images of the HI surface densities and the intensity weighted velocity fields with optical images from SDSS and WIYN. These data allow us to localize the HI gas and to study the bulk neutral gas kinematics.Support for this work was provided by NSF grant AST-1211683 to JMC at Macalester College.

  18. Validation of SAGE II NO2 measurements

    NASA Technical Reports Server (NTRS)

    Cunnold, D. M.; Zawodny, J. M.; Chu, W. P.; Mccormick, M. P.; Pommereau, J. P.; Goutail, F.

    1991-01-01

    The validity of NO2 measurements from the stratospheric aerosol and gas experiment (SAGE) II is examined by comparing the data with climatological distributions of NO2 and by examining the consistency of the observations themselves. The precision at high altitudes is found to be 5 percent, which is also the case at specific low altitudes for certain latitudes where the mixing ratio is 4 ppbv, and the precision is 0.2 ppbv at low altitudes. The autocorrelation distance of the smoothed profile measurement noise is 3-5 km and 10 km for 1-km and 5-km smoothing, respectively. The SAGE II measurements agree with spectroscopic measurements to within 10 percent, and the SAGE measurements are about 20 percent smaller than average limb monitor measurements at the mixing ratio peak. SAGE I and SAGE II measurements are slightly different, but the difference is not attributed to changes in atmospheric NO2.

  19. Intrafibrillar Mineral May be Absent in Dentinogenesis Imperfecta Type II (DI-II)

    SciTech Connect

    Pople, John A.

    2001-03-29

    High-resolution synchrotron radiation computed tomography (SRCT) and small angle x-ray scattering (SAXS) were performed on normal and dentinogenesis imperfecta type II (DI-II) teeth. Three normal and three DI-II human third molars were used in this study. The normal molars were unerupted and had intact enamel; donors were female and ranged in age from 18-21y. The DI-II specimens, which were also unerupted with intact enamel, came from a single female donor age 20y. SRCT showed that the mineral concentration was 33% lower on average in the DI-II dentin with respect to normal dentin. The SAXS spectra from normal dentin exhibited low-angle diffraction peaks at harmonics of 67.6 nm, consistent with nucleation and growth of the apatite phase within gaps in the collagen fibrils (intrafibrillar mineralization). In contrast, the low-angle peaks were almost nonexistent in the DI-II dentin. Crystallite thickness was independent of location in both DI-II and normal dentin, although the crystallites were significantly thicker in DI-II dentin (6.8 nm (s.d. = 0.5) vs 5.1 nm (s.d. = 0.6)). The shape factor of the crystallites, as determined by SAXS, showed a continuous progression in normal dentin from roughly one-dimensional (needle-like) near the pulp to two-dimensional (plate-like) near the dentin-enamel junction. The crystallites in DI-II dentin, on the other hand, remained needle-like throughout. The above observations are consistent with an absence of intrafibrillar mineral in DI-II dentin.

  20. Competitive adsorption of Cu(II)-EDTA and Cd(II)-EDTA onto TiO{sub 2}

    SciTech Connect

    Yang, J.K.; Davis, A.P.

    1999-08-01

    Cu(II), EDTA, Cu(II)-EDTA, Cd(II)-EDTA, and Cu(II)/Cd(II) and Cu(II)-EDTA/Cd(II)-EDTA competitive adsorption onto TiO{sub 2} has been studied with variation of pH and concentration. For Cu(II) and EDTA, typical cationic and anionic types of adsorption are noted, respectively. Ligand-type adsorption is found for Cu(II)-EDTA and Cd(II)-EDTA under both single and competitive conditions. Surface complexation modeling considered inner-sphere complexation and the diffuse layer model employing MINTEQA2; surface complexes used include Ti-(OH{sub 2})O-Cu{sup +}, Ti-(OH)EDTAH{sub 2}{sup {minus}2}, Ti-(OH)EDTA-Cu{sup {minus}2}, and Ti-(OH)EDTA-Cd{sup {minus}2}. Experimental and model predictions suggest no competitive adsorption between Cu(II) and Cd(II) at 5 {times} 10{sup {minus}5} M. On the other hand, adsorption data and model predictions indicate that Cd(II)-EDTA adsorption is favored over that of Cu(II)-EDTA with some competition for adsorption sites. Cd(II)-EDTA Adsorption was only slightly affected by the presence of Cu(II)-EDTA; however, Cu(II)-EDTA adsorption was strongly influenced by the presence of Cd(II)-EDTA, especially as the molar ratio of Cd(II)-EDTA/Cu(II)-EDTA increased. A modified surface complexation constant for Cd(II)-EDTA is required to explain the competitive data, suggesting surface site heterogeneity.

  1. Testicular gonadotropin-releasing hormone II receptor (GnRHR-II) knockdown constitutively impairs diurnal testosterone secretion in the boar

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The second mammalian GnRH isoform (GnRH-II) and its specific receptor (GnRHR-II) are highly expressed in the testis, suggesting an important role in testis biology. Gene coding errors prevent the production of GnRH-II and GnRHR-II in many species, but both genes are functional in swine. We have demo...

  2. Psychometric Properties of the Beck Depression Inventory-II (BDI-II) among Community-Dwelling Older Adults

    ERIC Educational Resources Information Center

    Segal, Daniel L.; Coolidge, Frederick L.; Cahill, Brian S.; O'Riley, Alisa A.

    2008-01-01

    The psychometric properties of the Beck Depression Inventory-II (BDI-II) as a self-administered screening tool for depressive symptoms were examined in a sample of community-dwelling older and younger adults. Participants completed the BDI-II, the Center for Epidemiologic Studies Depression Scale, the Coolidge Axis II Inventory, the Perceived…

  3. VizieR Online Data Catalog: Parity-forbidden [Co II] and [V II] lines (Ruffoni+, 2013)

    NASA Astrophysics Data System (ADS)

    Ruffoni, M. P.; Pickering, J. C.

    2013-09-01

    The Ritz wavelengths of the parity-forbidden [Co II] and [V II] lines reported here were calculated, respectively, from the accurate Co II energy levels reported by Pickering et al. (1998ApJS..117..261P) and the revised accurate V II energy levels measured by Thorne et al. (2013, Cat. J/ApJS/207/13). (4 data files).

  4. DO GIANT PLANETS SURVIVE TYPE II MIGRATION?

    SciTech Connect

    Hasegawa, Yasuhiro; Ida, Shigeru E-mail: ida@geo.titech.ac.jp

    2013-09-10

    Planetary migration is one of the most serious problems to systematically understand the observations of exoplanets. We clarify that the theoretically predicted type II, migration (like type I migration) is too fast, by developing detailed analytical arguments in which the timescale of type II migration is compared with the disk lifetime. In the disk-dominated regime, the type II migration timescale is characterized by a local viscous diffusion timescale, while the disk lifetime is characterized by a global diffusion timescale that is much longer than the local one. Even in the planet-dominated regime where the inertia of the planet mass reduces the migration speed, the timescale is still shorter than the disk lifetime except in the final disk evolution stage where the total disk mass decays below the planet mass. This suggests that most giant planets plunge into the central stars within the disk lifetime, and it contradicts the exoplanet observations that gas giants are piled up at r {approx}> 1 AU. We examine additional processes that may arise in protoplanetary disks: dead zones, photoevaporation of gas, and gas flow across a gap formed by a type II migrator. Although they make the type II migration timescale closer to the disk lifetime, we show that none of them can act as an effective barrier for rapid type II migration with the current knowledge of these processes. We point out that gas flow across a gap and the fraction of the flow accreted onto the planets are uncertain and they may have the potential to solve the problem. Much more detailed investigation for each process may be needed to explain the observed distribution of gas giants in extrasolar planetary systems.

  5. Five coordinate M(II)-diphenolate [M = Zn(II), Ni(II), and Cu(II)] Schiff base complexes exhibiting metal- and ligand-based redox chemistry.

    PubMed

    Franks, Mark; Gadzhieva, Anastasia; Ghandhi, Laura; Murrell, David; Blake, Alexander J; Davies, E Stephen; Lewis, William; Moro, Fabrizio; McMaster, Jonathan; Schröder, Martin

    2013-01-18

    Five-coordinate Zn(II), Ni(II), and Cu(II) complexes containing pentadentate N(3)O(2) Schiff base ligands [1A](2-) and [1B](2-) have been synthesized and characterized. X-ray crystallographic studies reveal five coordinate structures in which each metal ion is bound by two imine N-donors, two phenolate O-donors, and a single amine N-donor. Electron paramagnetic resonance (EPR) spectroscopic studies suggest that the N(3)O(2) coordination spheres of [Cu(1A)] and [Cu(1B)] are retained in CH(2)Cl(2) solution and solid-state superconducting quantum interference device (SQUID) magnetometric studies confirm that [Ni(1A)] and [Ni(1B)] adopt high spin (S = 1) configurations. Each complex exhibits two reversible oxidation processes between +0.05 and +0.64 V vs [Fc](+)/[Fc]. The products of one- and two-electron oxidations have been studied by UV/vis spectroelectrochemistry and by EPR spectroscopy which confirm that each oxidation process for the Zn(II) and Cu(II) complexes is ligand-based with sequential formation of mono- and bis-phenoxyl radical species. In contrast, the one-electron oxidation of the Ni(II) complexes generates Ni(III) products. This assignment is supported by spectroelectrochemical and EPR spectroscopic studies, density functional theory (DFT) calculations, and the single crystal X-ray structure of [Ni(1A)][BF(4)] which contains Ni in a five-coordinate distorted trigonal bipyramidal geometry.

  6. Type II endometrial cancers: A case series

    PubMed Central

    Lobo, Flora D.; Thomas, Eliz

    2016-01-01

    Introduction: Endometrial carcinoma ranks 3rd in India among gynecological malignancies. Endometrial cancer (EC) can be classified into two distinct groups – type I and type II, based on histology, which differs in molecular, clinical and histopathological profiles. Type II is nonestrogen dependent, nonendometrioid, more aggressive and carries poor prognosis. Although type II cancers contribute only about 10% of EC incidence, they present at advanced age and cause approximately 50% recurrence and deaths with a low 5-year, overall survival rate. Type II EC are also characterized by genetic alterations in p53, human epidermal growth factor-2/neu, p16 and E-cadherin. Materials and Methods: Endometrial carcinomas diagnosed from endometrial biopsies and hysterectomy specimens received in the Department of Pathology, Kasturba Medical College, Mangalore, from January 2007 to June 2012 were included in the study. Clinicopathological analysis of the 84 cases of EC was done with emphasis on morphology. p53 immunostaining was performed in two cases of serous carcinoma. Results: Out of a total of 84 cases of EC, ten cases were of type II (11.9%). Out of which, eight were serous carcinoma (9.5%) and two clear cell (2.4%). p53 immunostain was strongly positive in the serous papillary carcinomas. The age of the patients ranged from 45 to 75 years. Myometrial invasion was more than half. Treatment was hysterectomy followed by aggressive chemotherapy. Conclusion: Of the type II EC, serous carcinoma is the most common type. Clinical presentation and prognosis differs in comparison to type I EC, thus the recognition of this type of EC is pivotal. PMID:27499593

  7. The Mark II Vertex Drift Chamber

    SciTech Connect

    Alexander, J.P.; Baggs, R.; Fujino, D.; Hayes, K.; Hoard, C.; Hower, N.; Hutchinson, D.; Jaros, J.A.; Koetke, D.; Kowalski, L.A.

    1989-03-01

    We have completed constructing and begun operating the Mark II Drift Chamber Vertex Detector. The chamber, based on a modified jet cell design, achieves 30 {mu}m spatial resolution and <1000 {mu}m track-pair resolution in pressurized CO{sub 2} gas mixtures. Special emphasis has been placed on controlling systematic errors including the use of novel construction techniques which permit accurate wire placement. Chamber performance has been studied with cosmic ray tracks collected with the chamber located both inside and outside the Mark II. Results on spatial resolution, average pulse shape, and some properties of CO{sub 2} mixtures are presented. 10 refs., 12 figs., 1 tab.

  8. SLUDGE BATCH 6 PHASE II FLOWSHEET SIMULATIONS

    SciTech Connect

    Koopman, D.; Best, D.

    2010-03-30

    Two Sludge Receipt and Adjustment Tank (SRAT) runs were used to demonstrate that a fairly wide window of acid stoichiometry was available for processing SB6 Phase II flowsheet simulant (Tank 40 simulant) while still meeting the dual goals of acceptable nitrate destruction and controlled hydrogen generation. Phase II was an intermediate flowsheet study for the projected composition of Tank 40 after transfer of SB6/Tank 51 sludge to the heel of SB5. The composition was based on August 2009 projections. A window of about 50% in total acid was found between acceptable nitrite destruction and excessive hydrogen generation.

  9. Atypical presentations in Chiari II malformation.

    PubMed

    Rath, G P; Bithal, P K; Chaturvedi, A

    2006-01-01

    Myelomeningocele with Chiari II malformation and hydrocephalus is a common association seen in infants with a congenital failure of neurulation. Here we report two cases of such an association presenting with different sets of problems. The first patient presented with severe inspiratory stridor due to bilateral abductor vocal cord paralysis, which was relieved completely within 24 h of definitive surgery. The second patient experienced intraoperative cardiac arrest. Definitive surgery was followed after successful cardiopulmonary resuscitation. The cause of the perioperative sequence of events in both cases is attributed to the associated pathologies of Chiari II malformation.

  10. trans-Bis(hexafluoroantimonato)(phthalocyaninato)copper(II).

    PubMed

    Gardberg, A S; Ibers, J A

    2001-05-01

    The title compound, trans-bis(hexafluoroantimonato-F)(phthalocyaninato-kappa(4)N(29,30,31,32))copper(II), [Cu(SbF(6))(2)(C(32)H(16)N(8))] or Cu(pc)(SbF(6))(2) (pc is phthalocyaninate), comprises a six-coordinate Cu atom, lying on an inversion center, bonded to four N atoms of a phthalocyanine ring and to F atoms of two trans SbF(6)(-) groups. The compound is presumed to consist of a Cu(II) center and a doubly oxidized phthalocyanine ring, by analogy with Cu(pc)(ReO(4))(2).

  11. Ground Motion Studies at NSLS II

    SciTech Connect

    Simos,N.; Fallier, M.; Amick, H.

    2008-06-23

    In this study, an array of vibration measurements at the undisturbed NSLS II site has been performed in order to establish the 'green-field' vibration environment and its spectral characteristics. The interaction of the green-field vibration environment with the NSLS II accelerator structure and the quantification of the storage ring vibration, both in terms of amplitude and spectral content have been assessed through a state-of-the-art wave propagation and scattering analysis. This paper focuses on the wave propagation and scattering aspect as well as on the filtering effects of accelerator structural parameters.

  12. Paralysis Episodes in Carbonic Anhydrase II Deficiency.

    PubMed

    Al-Ibrahim, Alia; Al-Harbi, Mosa; Al-Musallam, Sulaiman

    2003-01-01

    Carbonic anhydrase II (CAII) deficiency is an autosomal recessive disorder manifest by osteopetrosis, renal tubular acidosis, and cerebral calcification. Other features include growth failure and mental retardation. Complications of the osteopetrosis include frequent bone fractures, cranial nerve compression, and dental mal-occlusion. A hyper-chloremic metabolic acidosis, sometimes with hypokalemia, occurs due to renal tubular acidosis that may be proximal, distal, or more commonly, the combined type. Such patients may present with global hypotonia, muscle weakness or paralysis. We report a case of CA II deficiency with recurrent attacks of acute paralysis which was misdiagnosed initially as Guillian-Barre syndrome.

  13. Site Environmental Report for 1998 Volume II

    SciTech Connect

    Ruggieri, Michael

    1999-09-30

    Volume II of the Site Environment Report for 1998 is provided by Ernest Orlando Lawrence Berkeley National Laboratory as a supplemental appendix to the report printed in volume I. Volume II contains the environmental monitoring and sampling data used to generate summary results in the main report for routine and non routine activities at the Laboratory (except for groundwater sampling data, which may be found in the reports referred to in chapter 6). Data presented in the tables are given in International System of Units (SI) units of measure.

  14. Touschek Lifetime Calculations for NSLS-II

    SciTech Connect

    Nash,B.; Kramer, S.

    2009-05-04

    The Touschek effect limits the lifetime for NSLS-II. The basic mechanism is Coulomb scattering resulting in a longitudinal momentum outside the momentum aperture. The momentum aperture results from a combination of the initial betatron oscillations after the scatter and the non-linear properties determining the resultant stability. We find that higher order multipole errors may reduce the momentum aperture, particularly for scattered particles with energy loss. The resultant drop in Touschek lifetime is minimized, however, due to less scattering in the dispersive regions. We describe these mechanisms, and present calculations for NSLS-II using a realistic lattice model including damping wigglers and engineering tolerances.

  15. Validation of SAGE II ozone measurements

    NASA Technical Reports Server (NTRS)

    Cunnold, D. M.; Chu, W. P.; Mccormick, M. P.; Veiga, R. E.; Barnes, R. A.

    1989-01-01

    Five ozone profiles from the Stratospheric Aerosol and Gas Experiment (SAGE) II are compared with coincident ozonesonde measurements obtained at Natal, Brazil, and Wallops Island, Virginia. It is shown that the mean difference between all of the measurements is about 1 percent and that the agreement is within 7 percent at altitudes between 20 and 53 km. Good agreement is also found for ozone mixing ratios on pressure surfaces. It is concluded that the SAGE II profiles provide useful ozone information up to about 60 km altitude.

  16. CDF - Run II Status and Prospects

    SciTech Connect

    Manfred Paulini

    2003-03-17

    After a five year upgrade period, the CDF detector located at the Fermilab Tevatron Collider is back in operation taking high quality data with all subsystems functional. We report on the status of the CDF experiment in Run II and discuss the start-up of the Tevatron accelerator. First physics results from CDF are presented. We also discuss the prospects for B physics in RunII, in particular the measurements of B{sub S}{sup 0} flavour oscillations and CP violation in B decays.

  17. Spectroscopic evaluation for VO(II), Ni(II), Pd(II) and Cu(II) complexes derived from thiosemicarbazide: A special emphasis on EPR study and DNA cleavage

    NASA Astrophysics Data System (ADS)

    El-Metwally, Nashwa M.; Al-Hazmi, Gamil A. A.

    2013-04-01

    Some thiosemicarbazide complexes were prepared and deliberately investigated by all allowed tools. The ligand coordinates as a mono negative bidentate towards VO(II) and Ni(II) as well as a neutral bidentate towards Pd(II) and Cu(II) ions. Electronic spectral data beside the magnetic measurements facilitate the structural geometry proposal. EPR spectra of Cu(II) and VO(II) complexes were recorded in their solid state. Spin Hamiltonian parameters and molecular orbital coefficient for Cu(II) and VO(II) complexes were calculated and supporting the octahedral geometry of Cu(II) complex and a square pyramidal for VO(II) one. The biological activity investigation was studied by the use of all prepared compounds. The VO(II) and Cu(II) complexes display the susceptible biotoxicity against a gram-positive bacterium. Also, Cu(II) complex displays the same toxicity against gram-negative bacteria used. The effect of all compounds on DNA were photographed. A successive degradation for the DNA target was observed with Pd(II) and Ni(II) complexes beside their original ligand.

  18. Sensitive electrochemical sensor using a graphene-polyaniline nanocomposite for simultaneous detection of Zn(II), Cd(II), and Pb(II).

    PubMed

    Ruecha, Nipapan; Rodthongkum, Nadnudda; Cate, David M; Volckens, John; Chailapakul, Orawon; Henry, Charles S

    2015-05-18

    This work describes the development of an electrochemical sensor for simultaneous detection of Zn(II), Cd(II), and Pb(II) using a graphene-polyaniline (G/PANI) nanocomposite electrode prepared by reverse-phase polymerization in the presence of polyvinylpyrrolidone (PVP). Two substrate materials (plastic film and filter paper) and two nanocomposite deposition methods (drop-casting and electrospraying) were investigated. Square-wave anodic stripping voltammetry currents were higher for plastic vs. paper substrates. Performance of the G/PANI nanocomposites was characterized by scanning electron microscopy (SEM) and cyclic voltammetry. The G/PANI-modified electrode exhibited high electrochemical conductivity, producing a three-fold increase in anodic peak current (vs. the unmodified electrode). The G/PANI-modified electrode also showed evidence of increased surface area under SEM. Square-wave anodic stripping voltammetry was used to measure Zn(II), Cd(II), and Pb(II) in the presence of Bi(III). A linear working range of 1-300 μg L(-1) was established between anodic current and metal ion concentration with detection limits (S/N=3) of 1.0 μg L(-1) for Zn(II), and 0.1 μg L(-1) for both Cd(II) and Pb(II). The G/PANI-modified electrode allowed selective determination of the target metals in the presence of common metal interferences including Mn(II), Cu(II), Fe(III), Fe(II), Co(III), and Ni(II). Repeat assays on the same device demonstrated good reproducibility (%RSD<11) over 10 serial runs. Finally, this system was utilized for determining Zn(II), Cd(II), and Pb(II) in human serum using the standard addition method.

  19. Spectroscopic (FT-IR, FT-Raman, 1H, 13C NMR, UV/VIS), thermogravimetric and antimicrobial studies of Ca(II), Mn(II), Cu(II), Zn(II) and Cd(II) complexes of ferulic acid

    NASA Astrophysics Data System (ADS)

    Kalinowska, M.; Piekut, J.; Bruss, A.; Follet, C.; Sienkiewicz-Gromiuk, J.; Świsłocka, R.; Rzączyńska, Z.; Lewandowski, W.

    2014-03-01

    The molecular structure of Mn(II), Cu(II), Zn(II), Cd(II) and Ca(II) ferulates (4-hydroxy-3-methoxycinnamates) was studied. The selected metal ferulates were synthesized. Their composition was established by means of elementary and thermogravimetric analysis. The following spectroscopic methods were used: infrared (FT-IR), Raman (FT-Raman), nuclear magnetic resonance (13C, 1H NMR) and ultraviolet-visible (UV/VIS). On the basis of obtained results the electronic charge distribution in studied metal complexes in comparison with ferulic acid molecule was discussed. The microbiological study of ferulic acid and ferulates toward Escherichia coli, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus and Proteus vulgaris was done.

  20. Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) new complexes of 5-aminosalicylic acid: Spectroscopic, thermal characterization and biological activity studies

    NASA Astrophysics Data System (ADS)

    Soliman, Madiha H.; Mohamed, Gehad G.

    2013-04-01

    The complexing behavior of mesalazine (5-aminosalicylic acid; 5-ASA) towards the transition metal ions namely, Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) have been examined by elemental analyses, magnetic measurements, electronic, IR and 1H NMR. Thermal properties and decomposition kinetics of all complexes are investigated. The interpretation, mathematical analyses and evaluation of kinetic parameters of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The free ligand and its metal complexes have been tested in vitro against Aspergillus fumigatus and Candida albicans fungi and Pseudomonas aeruginosa, Escherichia coli, Bacillis subtilies and Staphylococcus aureus bacteria in order to assess their antimicrobial potential. The results indicate that the metal complexes are also found to have more antimicrobial activity than the parent 5-ASA drug.

  1. Adsorption and desorption of Cu(II), Cd(II) and Pb(II) ions using chitosan crosslinked with epichlorohydrin-triphosphate as the adsorbent.

    PubMed

    Laus, Rogério; Costa, Thiago G; Szpoganicz, Bruno; Fávere, Valfredo T

    2010-11-15

    In this study, chitosan (CTS) was crosslinked with both epichlorohydrin (ECH) and triphosphate (TPP), by covalent and ionic crosslinking, respectively. The resulting new CTS-ECH-TPP adsorbent was characterized by CHN analysis, EDS, FTIR spectroscopy, TGA and DSC, and the adsorption and desorption of Cu(II), Cd(II) and Pb(II) ions in aqueous solution were investigated. Potentiometric studies were also performed and revealed three titratable protons for each pK(a) value of 5.14, 6.76 and 9.08. The results obtained showed that the optimum pH values for adsorption were 6.0 for Cu(II), 7.0 for Cd(II) and 5.0 for Pb(II). The kinetics study demonstrated that the adsorption process proceeded according to the pseudo-second-order model. Three isotherm models (Langmuir, Freundlich and Dubinin-Radushkevich) were employed in the analysis of the adsorption equilibrium data. The Langmuir model resulted in the best fit and the new adsorbent had maximum adsorption capacities for Cu(II), Cd(II) and Pb(II) ions of 130.72, 83.75 and 166.94 mg g(-1), respectively. Desorption studies revealed that HNO(3) and HCl were the best eluents for desorption of Cu(II), Cd(II) and Pb(II) ions from the crosslinked chitosan.

  2. Copper(II) and nickel(II) binding sites of peptide containing adjacent histidyl residues.

    PubMed

    Grenács, Ágnes; Sanna, Daniele; Sóvágó, Imre

    2015-10-01

    Copper(II) and nickel(II) complexes of the terminally protected nonapeptide Ac-SGAEGHHQK-NH2 modeling the metal binding sites of the (8-16) domain of amyloid-β have been studied by potentiometric, UV-vis, CD and ESR spectroscopic methods. The studies on the mutants containing only one of the histidyl residues (Ac-SGAEGAHQK-NH2, Ac-SGAEGHAQK-NH2) have also been performed. The formation of imidazole and amide coordinated mononuclear complexes is characteristic of all systems with a preference of nickel(II) binding to the His14 site, while the involvement of both histidines in metal binding is suggested in the corresponding copper(II) complexes. The formation of bis(ligand) and dinuclear complexes has also been observed in the copper(II)-Ac-SGAEGHHQK-NH2 system. The results provide further support for the copper(II) binding ability of the (8-16) domain of amyloid-β and support the previous assumptions that via the bis(ligand) complex formation copper(II) ions may promote the formation of the oligomers of amyloid-β.

  3. Biosorption studies on copper (II) and cadmium (II) using pretreated rice straw and rice husk.

    PubMed

    Li, W C; Law, F Y; Chan, Y H M

    2015-07-25

    This study investigated the adsorption and removal behaviour of copper (Cu) (II) and cadmium (Cd) (II) ions using rice husk and rice straw in aqueous solutions. Different parameters were used to investigate their adsorption performance in saline conditions and the optimal level of biosorption at different pH levels. The main parameters were pH (3, 6 and 9), initial concentration level of heavy metals (Cu (II) 5, 10, 20, 40 and 60 mg/L and Cd (II) 0.5, 1, 2, 4 and 8 mg/L, respectively), salinity (0, 50 and 100 mM NaCl) and contact time (ranging from 3 to 60 min). Langmuir and Freundlich isotherm models were applied to analyse the removal efficiency and sorption capacity of the pretreated rice husk and rice straw. The removal efficiency and adsorption capacity generally increased with the pH and reached a plateau in alkaline conditions. The percentage removal of Cu (II) by rice husk reached 97 % at pH 9 and 95 % by rice straw at pH 6. Biosorption performance increased in the absence of NaCl. Kinetic studies for both metals revealed that the biosorption of Cu (II) and Cd (II) onto rice straw and husk was pseudo-second order.

  4. Solvent Refined Coal-II (SRC-II) detailed environmental plan

    SciTech Connect

    Not Available

    1980-10-01

    This document describes environmental research which will: aid in the development of an environmentally acceptable SRC-II process; and provide data for environmental assessment of the process. The SRC-II process is described, criteria for selection of samples to undergo environmental analyses are given, and approximate timelines are presented for obtaining pertinent samples. At this time, the SRC-II process is at the pilot-plant stage of development and a demonstration facility is scheduled to begin operation in 1984. Since design criteria may change, the environmental research described in this document is organized in four phases which correlate with and will provide information early in process development. Phase I research (screening) evaluates samples from existing SRC-II facilities (pilot, process demonstration unit (PDU), bench) which may bracket potential demonstration/commercial practice in terms of physical and chemical criteria. The samples are being subjected to a battery of short-term biomedical and ecological assays. Chemical fractionation and analysis are being performed to determine compounds and compound classes of potential concern. Phase II (baseline) research will evaluate SRC-II materials which are considered most representative of potential demonstration/commercial practice. These materials will be subjected to longer-term, more-extensive biological and ecological analyses relative to effects and environmental fate. Phase III research will examine effects of process modification, control technologies and changing operational conditions on potential environmental properties of SRC-II materials. Phase IV research (onsite monitoring) will develop methods and initiate environmental monitoring for effects at the SRC-II demonstration facility and potential commercial sites. This document also describes industrial hygiene programs which must occur throughout SRC-II process development.

  5. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression

    PubMed Central

    Leung, Chi Ming; Yim, Chi Lap; Yan, Connie T. Y.; Chan, Cheuk Chi; Xiang, Yu-Tao; Mak, Arthur D. P.; Fok, Marcella Lei-Yee; Ungvari, Gabor S.

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8%) were males and 233 (78.2%) females. There were 112 (37.6%) subjects with BP depression [BP-I = 42 (14.1%), BP-II = 70 (23.5%)] and 182 (62.4%) with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results. PMID:26963908

  6. Army Base Realignment Methodology. Volume II.

    DTIC Science & Technology

    1981-08-01

    Command Operating Program Detailed Guidance FE ii...........Final Environmental Impact Statement FWA ........... Family Houslag Management Account FNSI...effectively systematized the requirements included within the environmental , socio- economic, and EEO realms. HtQDA and MACOM personnel are indeed...This study asesses the current methodology for studying potential Army rea- lignment actions and recommends a system for tracking actions once they

  7. Results of the NSLS-II commissioning

    NASA Astrophysics Data System (ADS)

    Wang, Guimei; Shaftan, Timur; Willeke, Ferdinand; NSLS Team, II

    2015-04-01

    The National Synchrotron Light Source II at Brookhaven National Lab is a third-generation synchrotron radiation facility that has been commissioned in 2014. The facility is based on a 3 GeV electron storage ring, which will circulate 500 mA of beam current at 1 nm rad of horizontal emittance. The storage ring is 792 meters in circumference and will accommodate more than 60 beamlines in the final built-out. The beamline sources range from insertion-devices located in straight sections, bending magnets or three-pole-wigglers configured in multiple branches. The linac commissioning activities started in March of 2012 and was accomplished in several weeks. In Dec. 2013 the booster commissioning commenced and reached its goal in February 2014. The commissioning of the NSLS-II storage ring was successfully completed in July 2014, taking about two months in total. The storage ring is now operating at 50 mA with 3 sets of Damping Wigglers resulting in 1 nm rad of horizontal emittance. We delivered the first user light on October 23, 2014. At this point six NSLS-II project beamlines are routinely taking photons since November of 2014. In this presentation I review the NSLS-II accelerator design and our experience with getting ready for the machine start-up. In the following I focus on the commissioning results and present details, issues and advances in reaching the commissioning milestones.

  8. Distributive Education II. Course of Study.

    ERIC Educational Resources Information Center

    Nelson, Frank W.

    This curriculum guide for teacher-coordinators is designed to provide a course of study in distributive education (Distributive Education II) in Oklahoma. Content is in nine sections with each section consisting of one or more instructional units: (1) Orientation (Introduction to Distributive Occupations, DECA), (2) Survival Skills (Job…

  9. Theory of Aircraft Flight. Aerospace Education II.

    ERIC Educational Resources Information Center

    Elmer, James D.

    This revised textbook, one in the Aerospace Education II series, provides answers to many questions related to airplanes and properties of air flight. The first chapter provides a description of aerodynamic forces and deals with concepts such as acceleration, velocity, and forces of flight. The second chapter is devoted to the discussion of…

  10. Redetermination of (d-penicillaminato)lead(II)

    PubMed Central

    Schell, Adam C.; Parvez, Masood; Jalilehvand, Farideh

    2012-01-01

    In the title coordination polymer, [Pb(C5H9NO2S)]n {systematic name: catena-poly[(μ-2-amino-3-methyl-3-sulfido­butano­ato)lead(II)]}, the d-penicillaminate ligand coordin­ates to the metal ion in an N,S,O-tridentate mode. The S atom acts as a bridge to two neighbouring PbII ions, thereby forming a double thiol­ate chain. Moreover, the coordinating carboxyl­ate O atom forms bridges to the PbII ions in the adjacent chain. The overall coordination sphere of the PbII ion can be described as a highly distorted penta­gonal bipyramid with a void in the equatorial plane between the long Pb—S bonds probably occupied by the stereochemically active inert electron pair. The amino H atoms form N—H⋯S and N—H⋯O hydrogen bonds, resulting in a cluster of four complex units, giving rise to an R 4 4(16) ring lying in the ab plane. The crystal structure of the title compound has been reported previously [Freeman et al. (1974 ▶). Chem. Soc. Chem. Commun. pp. 366–367] but the atomic coordinates have not been deposited in the Cambridge Structural Database (refcode DPENPB). Additional details of the hydrogen bonding are presented here. PMID:22589847

  11. Report of Programme Commission II (Natural Sciences).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). General Conference.

    As the first part of the report of the Programme Commission II, a summary of discussions on plans for natural sciences and their applications is presented in this document. The two agenda items are: (1) detailed consideration of the 1973-74 draft program and budget and of the 1973-78 draft medium-term outline, and (2) desirability of adopting an…

  12. EBR-II fuel slug casting experience

    SciTech Connect

    Wilkes, C. W.; Batte`, G. L.; Tracy, D. B.; Griffiths, V.

    1987-07-01

    The following paper presents a chronology of EBR-II fuel slug casting experience. Starting with the early vendor campaigns, the paper explains how production of EBR-II fuel, as well as fuel for off-site reactors, has evolved. The production facilities (i.e., EFL, Room 20, FMF, etc.) and casting techniques are discussed in detail. The paper also presents how the original casting operations have improved and the problems encountered as the techniques were developed. Extensive descriptions and data are given on the major experimental programs currently ongoing at EBR-II. Major programs include the IFR lead subassemblies, large diameter slugs, IFR metal fuel RBCB, and the FFTF subassembly program. Concluding the paper is a brief description of future development projects being considered and a summation of how EBR-II Fuels and Materials has been able to overcome various administration obstacles (i.e., improved security and safeguards measures) to continue to meet the increasing demands of fuel production while maintaining an aggressive and active research and development program in fuel slug production.

  13. Project Final Report: HPC-Colony II

    SciTech Connect

    Jones, Terry R; Kale, Laxmikant V; Moreira, Jose

    2013-11-01

    This report recounts the HPC Colony II Project which was a computer science effort funded by DOE's Advanced Scientific Computing Research office. The project included researchers from ORNL, IBM, and the University of Illinois at Urbana-Champaign. The topic of the effort was adaptive system software for extreme scale parallel machines. A description of findings is included.

  14. The Uptake Mechanism of Cd(II), Cr(VI), Cu(II), Pb(II), and Zn(II) by Mycelia and Fruiting Bodies of Galerina vittiformis

    PubMed Central

    Damodaran, Dilna; Balakrishnan, Raj Mohan; Shetty, Vidya K.

    2013-01-01

    Optimum concentrations of heavy metals like copper, cadmium, lead, chromium, and zinc in soil are essential in carrying out various cellular activities in minimum concentrations and hence help in sustaining all life forms, although higher concentration of these metals is lethal to most of the life forms. Galerina vittiformis, a macrofungus, was found to accumulate these heavy metals into its fleshy fruiting body in the order Pb(II) > Cd(II) > Cu(II) > Zn(II) > Cr(VI) from 50 mg/kg soil. It possesses various ranges of potential cellular mechanisms that may be involved in detoxification of heavy metals and thus increases its tolerance to heavy metal stress, mainly by producing organic acids and phytochelatins (PCs). These components help in repairing stress damaged proteins and compartmentalisation of metals to vacuoles. The stress tolerance mechanism can be deduced by various analytical tools like SEM-EDX, FTIR, and LC-MS. Production of two kinds of phytochelatins was observed in the organism in response to metal stress. PMID:24455671

  15. Ir Spectroscopy and Nickel (II) Hexammines

    ERIC Educational Resources Information Center

    Reedijk, J.; And Others

    1975-01-01

    Describes an experiment, for the general chemistry laboratory, intended to introduce the student to infrared spectroscopy. After being introduced to the theory of molecular vibrations on an elementary level, each student receives a list of 5-7 nickel (II) ammines to be prepared, analyzed and characterized by infrared spectoscopy. (MLH)

  16. Expertise revisited, Part II: Contributory expertise.

    PubMed

    Collins, Harry; Evans, Robert; Weinel, Martin

    2016-04-01

    In Part I of this two part paper we tried to elicit the 'essence' of the notion of interactional expertise by looking at its origins. In Part II we will look at the notion of contributory expertise. The exercise has been triggered by recent discussion of these concepts in this journal by Plaisance and Kennedy and by Goddiksen.

  17. Leveraging Information Technology. Track II: Innovative Management.

    ERIC Educational Resources Information Center

    CAUSE, Boulder, CO.

    Seven papers from the 1987 CAUSE conference's Track II, Innovative Management, are presented. They include: "Is This Creative, or What!" (Kenneth C. Blythe); "Joint Application Design: Can a User Committee Design a System in Four Days?" (Diane Kent, David Smithers); "Making It Happen without Appropriation" (Robert E.…

  18. A movie of RNA polymerase II transcription.

    PubMed

    Cheung, Alan C M; Cramer, Patrick

    2012-06-22

    We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

  19. Interrogation: World War II, Vietnam, and Iraq

    DTIC Science & Technology

    2008-09-01

    War II, he soft ened them with gift s of magazines, cig- arettes, and chocolates . He broke through their reserve with humor. And he spoke to them in...109. 208 Camp 020, 107. 96 | such as personality, mood , and acting ability.209 Noting that some interroga- tors would necessarily be incompatible with

  20. National Ignition Facility Title II Design Plan

    SciTech Connect

    Kumpan, S

    1997-03-01

    This National Ignition Facility (NIF) Title II Design Plan defines the work to be performed by the NIF Project Team between November 1996, when the U.S. Department of Energy (DOE) reviewed Title I design and authorized the initiation of Title H design and specific long-lead procurements, and September 1998, when Title 11 design will be completed.

  1. 24 CFR 202.12 - Title II.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Title II. 202.12 Section 202.12 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE...

  2. 24 CFR 202.12 - Title II.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Title II. 202.12 Section 202.12 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE...

  3. 24 CFR 202.12 - Title II.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Title II. 202.12 Section 202.12 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE...

  4. Occupational Information 1990/91. Volume II.

    ERIC Educational Resources Information Center

    Nebraska Univ., Lincoln. Nebraska Career Information System.

    The Nebraska Occupational Information books (volumes I and II) contain information about 386 different occupations in the state and answer questions about specific occupations in detail. The descriptions are arranged according to a U.S. Department of Labor classification system, with occupational titles clustered in general groups of selected…

  5. Tubing extrusion made easier, Part II.

    PubMed

    Ferrandino, Mike

    2004-11-01

    An increased understanding of the primary elements will lead to greater control of the extrusion process. In the ongoing quest to produce tubing with consistent properties. Part II of this two-part article makes recommendations on best practice in barrel and screw design, compression ratios and dies.

  6. A Camp Director Remembers World War II.

    ERIC Educational Resources Information Center

    Cohen, Helen Herz

    2003-01-01

    A girl's camp in Maine during World War II had to deal with food rationing and black-market food dealers. Campers picked beans to raise money for refugees, sewed clothes for refugees, and spotted for enemy planes from Mt. Pleasant. An attempt to use a horse-drawn cart for transportation failed, and good help was hard to find. (TD)

  7. Microbunching phenomena in LCLS-II

    SciTech Connect

    Venturini, M.; Qiang, J.; Papadopoulos, C.; Ding, Y.; Emma, P.; Huang, Z.; Marcus, G.; Marinelli, A.; Nosochkov, Y.; Raubenheimer, T.; Wang, L.; Woodley, M.

    2015-07-14

    The microbunching instability has long been recognized as a potential limiting factor to the performance of X-ray FELs. It is of particular relevance in LCLS-II due, in part, to a layout that includes a long bypass beamline between the Linac and the undulators. Here we focus on two aspects of the instability that highlight the importance of 3D effects.

  8. Basic Programming II: Course Guide. Revised Edition.

    ERIC Educational Resources Information Center

    Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

    This guide is designed to provide teachers with guidelines and suggested activities for teaching a one-semester advanced programming course--BASIC Programming II--for the ninth through twelfth grades. Although primarily oriented toward mathematics, the guide does offer sample applications in business that also address the needs of students with a…

  9. IDEA Oral Language Proficiency Test (IPT II).

    ERIC Educational Resources Information Center

    Stansfield, Charles W.

    The IDEA Oral Language Proficiency Test (IPT II), an individually-administered measure of speaking and listening proficiency in English as a Second Language designed for secondary school students, is described and discussed. The test consists of 91 items and requires 5-25 minutes to administer. Raw scores are converted to one of seven proficiency…

  10. PIP-II Transfer Line Design

    SciTech Connect

    Vivoli, A.

    2016-10-15

    The U.S. Particle Physics Project Prioritization Panel (P5) report encouraged the realization of Fermilab's Proton Improvement Plan II (PIP-II) to support future neutrino programs in the United States. PIP-II aims at enhancing the capabilities of the Fermilab existing accelerator complex while simultaneously providing a flexible platform for its future upgrades. The central part of PIP-II project is the construction of a new 800 MeV H- Superconducting (SC) Linac together with upgrades of the Booster and Main Injector synchrotrons. New transfer lines will also be needed to deliver beam to the down-stream accelerators and facilities. In this paper we present the recent development of the design of the transfer lines discussing the principles that guided their design, the constraints and requirements imposed by the existing accelerator complex and the following modifications implemented to comply with a better understanding of the limitations and further requirements that emerged during the development of the project.

  11. Arsenal Workers During World War II

    NASA Technical Reports Server (NTRS)

    1945-01-01

    During World War II, Arsenal workers from Huntsville, Alabama. and surrounding areas responded to the call for civilian defense workers. This February 20, 1945 photo shows workers filling colored smoke grenades that were used for signaling. (Courtesy of Huntsville/Madison County Public Library)

  12. The uptake mechanism of Cd(II), Cr(VI), Cu(II), Pb(II), and Zn(II) by mycelia and fruiting bodies of Galerina vittiformis.

    PubMed

    Damodaran, Dilna; Balakrishnan, Raj Mohan; Shetty, Vidya K

    2013-01-01

    Optimum concentrations of heavy metals like copper, cadmium, lead, chromium, and zinc in soil are essential in carrying out various cellular activities in minimum concentrations and hence help in sustaining all life forms, although higher concentration of these metals is lethal to most of the life forms. Galerina vittiformis, a macrofungus, was found to accumulate these heavy metals into its fleshy fruiting body in the order Pb(II) > Cd(II) > Cu(II) > Zn(II) > Cr(VI) from 50 mg/kg soil. It possesses various ranges of potential cellular mechanisms that may be involved in detoxification of heavy metals and thus increases its tolerance to heavy metal stress, mainly by producing organic acids and phytochelatins (PCs). These components help in repairing stress damaged proteins and compartmentalisation of metals to vacuoles. The stress tolerance mechanism can be deduced by various analytical tools like SEM-EDX, FTIR, and LC-MS. Production of two kinds of phytochelatins was observed in the organism in response to metal stress.

  13. [A case of type II achondrogenesis].

    PubMed

    Micheli, E; Perrone, C; Quarta Colosso, L; Vetrugno, M; Zecca, G; Indirli, G C; Greco, F; Elia, G; Ciancio, S

    1996-01-01

    We describe a rare case of type II achondrogenesis (gestational age = thirty-two weeks) dead forty-five minutes after birth. This congenital skeletal dysplasia is classified among the lethal osteochondrodysplasias. Clinical features were enough for diagnosis and autopsy added nothing to our clinical knowledges.

  14. Cu(II) promotes amyloid pore formation

    SciTech Connect

    Zhang, Hangyu; Rochet, Jean-Christophe; Stanciu, Lia A.

    2015-08-14

    The aggregation of α-synuclein is associated with dopamine neuron death in Parkinson's disease. There is controversy in the field over the question of which species of the aggregates, fibrils or protofibrils, are toxic. Moreover, compelling evidence suggested the exposure to heavy metals to be a risk of PD. Nevertheless, the mechanism of metal ions in promoting PD remains unclear. In this research, we investigated the structural basis of Cu(II) induced aggregation of α-synuclein. Using transmission electron microscopy experiments, Cu(II) was found to promote in vitro aggregation of α-synuclein by facilitating annular protofibril formation rather than fibril formation. Furthermore, neuroprotective baicalein disaggregated annular protofibrils accompanied by considerable decrease of β-sheet content. These results strongly support the hypothesis that annular protofibrils are the toxic species, rather than fibrils, thereby inspiring us to search novel therapeutic strategies for the suppression of the toxic annular protofibril formation. - Highlights: • Cu(II) promoted the annular protofibril formation of α-synuclein in vitro. • Cu(II) postponed the in vitro fibrillization of α-synuclein. • Neuroprotective baicalein disaggregated annular protofibrils.

  15. NSLS-II RF BEAM POSITION MONITOR

    SciTech Connect

    Vetter, K.; Della Penna, A. J.; DeLong, J.; Kosciuk, B.; Mead, J.; Pinayev, I.; Singh, O.; Tian, Y.; Ha, K.; Portmann, G.; Sebek J.

    2011-03-28

    An internal R&D program has been undertaken at BNL to develop a sub-micron RF Beam Position Monitor (BPM) for the NSLS-II 3rd generation light source that is currently under construction. The BPM R&D program started in August 2009. Successful beam tests were conducted 15 months from the start of the program. The NSLS-II RF BPM has been designed to meet all requirements for the NSLS-II Injection system and Storage Ring. Housing of the RF BPM's in +-0.1 C thermally controlled racks provide sub-micron stabilization without active correction. An active pilot-tone has been incorporated to aid long-term (8hr min) stabilization to 200nm RMS. The development of a sub-micron BPM for the NSLS-II has successfully demonstrated performance and stability. Pilot Tone calibration combiner and RF synthesizer has been implemented and algorithm development is underway. The program is currently on schedule to start production development of 60 Injection BPM's starting in the Fall of 2011. The production of {approx}250 Storage Ring BPM's will overlap the Injection schedule.

  16. Site Environmental Report for 2007 Volume II

    SciTech Connect

    Lackner, Regina E; Baskin, David; Fox, Robert; Jelinski, John; Pauer, Ron; Thorson, Patrick; Wahl, Linnea; Wyrick, Steve

    2008-09-15

    The Site Environmental Report for 2007 is an integrated report on the environmental programs at Lawrence Berkeley National Laboratory and satisfies the requirements of DOE Order 231.1A, Environment, Safety, and Health Reporting. Volume II contains individual data results from surveillance and monitoring activities.

  17. Site Environmental Report for 2008, Volume II

    SciTech Connect

    Lackner, Regina; Baskin, David; Fox, Robert; Jelinski, John; Pauer, Ron; Thorson, Patrick; Wahl, Linnea; Xu, Suying

    2009-09-21

    The Site Environmental Report for 2008 is an integrated report on environmental programs at Lawrence Berkeley National Laboratory and satisfies the requirements of DOE Order 231.1 A., Environment, Safety, and Health Reporting. Volume II contains individual data results from surveillance and monitoring activities

  18. Jet physics at CDF Run II

    SciTech Connect

    Safonov, A.; /UC, Davis

    2004-12-01

    The latest results on jet physics at CDF are presented and discussed. Particular attention is paid to studies of the inclusive jet cross section using 177 pb{sup -1} of Run II data. Also discussed is a study of gluon and quark jet fragmentation.

  19. Class II malocclusion occlusal severity description

    PubMed Central

    JANSON, Guilherme; SATHLER, Renata; FERNANDES, Thais Maria Freire; ZANDA, Marcelo; PINZAN, Arnaldo

    2010-01-01

    Objectives It is well known that the efficacy and the efficiency of a Class II malocclusion treatment are aspects closely related to the severity of the dental anteroposterior discrepancy. Even though, sample selection based on cephalometric variables without considering the severity of the occlusal anteroposterior discrepancy is still common in current papers. In some of them, when occlusal parameters are chosen, the severity is often neglected. The purpose of this study is to verify the importance given to the classification of Class II malocclusion, based on the criteria used for sample selection in a great number of papers published in the orthodontic journal with the highest impact factor. Material and Methods A search was performed in PubMed database for full-text research papers referencing Class II malocclusion in the history of the American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO). Results A total of 359 papers were retrieved, among which only 72 (20.06%) papers described the occlusal severity of the Class II malocclusion sample. In the other 287 (79.94%) papers that did not specify the anteroposterior discrepancy severity, description was considered to be crucial in 159 (55.40%) of them. Conclusions Omission in describing the occlusal severity demands a cautious interpretation of 44.29% of the papers retrieved in this study. PMID:20835576

  20. Angiotensin II Blockade and Renal Protection

    PubMed Central

    Kobori, Hiroyuki; Mori, Hirohito; Masaki, Tsutomu; Nishiyama, Akira

    2013-01-01

    Current national guidelines have recommended the use of renin-angiotensin system inhibitors, including angiotensin II type 1 receptor blockers (ARBs), in preference to other antihypertensive agents for treating hypertensive patients with chronic kidney disease. However, the mechanisms underlying the renoprotective effects of ARBs are multiple and complex. Blood pressure reduction by systemic vasodilation with an ARB contributes to its beneficial effects in treating kidney disease. Furthermore, ARB-induced renal vasodilation results in an increase in renal blood flow, leading to improvement of renal ischemia and hypoxia. ARBs are also effective in reducing urinary albumin excretion through a reduction in intraglomerular pressure and the protection of glomerular endothelium and/or podocyte injuries. In addition to blocking angiotensin II-induced renal cell and tissue injuries, ARBs can decrease intrarenal angiotensin II levels by reducing proximal tubular angiotensinogen and production of collecting duct renin, as well as angiotensin II accumulation in the kidney. In this review, we will briefly summarize our current understanding of the pharmacological effects of an ARB in the kidney. We will also discuss the possible mechanisms responsible for the renoprotective effects of ARBs on type 2 diabetic nephropathy. PMID:23176216

  1. Type II Technology Applications in Teacher Education:

    ERIC Educational Resources Information Center

    Chen Wang, Lih-Ching; Beasley, William

    2005-01-01

    The use of the Instant Messenger (IM) environment to carry out structured online class discussions in graduate teacher education courses is described. Properties of IM are delineated, and specific procedures in using IM as a vehicle for class discussions are discussed. Attributes of Type II technology applications are addressed directly, and the…

  2. Health Activities Project (HAP), Trial Edition II.

    ERIC Educational Resources Information Center

    Buller, Dave; And Others

    Contained within this Health Activities Project (HAP) trial edition (set II) are a teacher information folio and numerous student activity folios which center around the idea that students in grades 5-8 can control their own health and safety. Each student folio is organized into a Synopsis, Health Background, Materials, Setting Up, and Activities…

  3. Appalachian Bibliography, Volumes I and II.

    ERIC Educational Resources Information Center

    West Virginia Univ., Morgantown.

    The 2-volume Appalachian bibliography is alphabetically arranged by authors' last names under alphabetically listed subject headings. Volume I contains A-L subject headings, while Volume II contains L-W subject headings. The majority of the 8,220 documents cited are annotated and were published between 1891 and 1970. The bibliography contains such…

  4. Database for bacterial group II introns.

    PubMed

    Candales, Manuel A; Duong, Adrian; Hood, Keyar S; Li, Tony; Neufeld, Ryan A E; Sun, Runda; McNeil, Bonnie A; Wu, Li; Jarding, Ashley M; Zimmerly, Steven

    2012-01-01

    The Database for Bacterial Group II Introns (http://webapps2.ucalgary.ca/~groupii/index.html#) provides a catalogue of full-length, non-redundant group II introns present in bacterial DNA sequences in GenBank. The website is divided into three sections. The first section provides general information on group II intron properties, structures and classification. The second and main section lists information for individual introns, including insertion sites, DNA sequences, intron-encoded protein sequences and RNA secondary structure models. The final section provides tools for identification and analysis of intron sequences. These include a step-by-step guide to identify introns in genomic sequences, a local BLAST tool to identify closest intron relatives to a query sequence, and a boundary-finding tool that predicts 5' and 3' intron-exon junctions in an input DNA sequence. Finally, selected intron data can be downloaded in FASTA format. It is hoped that this database will be a useful resource not only to group II intron and RNA researchers, but also to microbiologists who encounter these unexpected introns in genomic sequences.

  5. SAGE II Version 7.00 Release

    Atmospheric Science Data Center

    2013-07-10

    ... algorithms from SAGE III v4.00 Ceased removal of the water vapor extinction in the 600nm channel due to uncertainty in the H2O ... (i.e. MLS and SAGE III versus HALOE) Fixed various bugs   Details are in the SAGE II V7.00 Release Notes . The ...

  6. Fiber, Fabric and Fashion. Environment II.

    ERIC Educational Resources Information Center

    Arizona State Univ., Tempe.

    A competency-based instructional guide for grades 7-14, this volume is one of three parts, each of which focuses on a different environment (psychomotor, cognitive, or affective), and each of which includes competencies and learning activities for each of three instructional levels. The topics for this volume (Environment II--cognitive) are…

  7. Metalloantibiotics: synthesis, characterization and in-vitro antibacterial studies on cobalt (II), copper (II), nickel (II) and zinc (II) complexes with cloxacillin.

    PubMed

    Chohan, Zahid H; Supuran, Claudiu T

    2006-08-01

    The synthesis and characterization of cloxacillin (clox) complexes with divalent metal ions [Co (II), Cu (II), Ni (II) and Zn (II)] is described. The nature of bonding of the chelated cloxacillin and the structures of the metal complexes have been elucidated on the basis of their physical and spectroscopic data. In all the complexes, the cloxacillin acts as a uninegatively charged bidentate ligand with coordination involving the carboxylate-O and endocyclic-N of the beta-lactam ring. The new compounds have been screened for in-vitro antibacterial activity against Escherichia coli (a), Klebsiella pneumonae (b), Proteus mirabilis (c), Pseudomonas aeruginosa (d), Salmonella typhi (e), Shigella dysentriae (f), Bacillus cereus (g), Corynebacterium diphtheriae (h), Staphylococcus aureus (j) and Streptococcus pyogenes (k) bacterial strains. The brine shrimp bioassay was also carried out to study their in-vitro cytotoxic properties. All compounds, respectively, showed a promising activity (90%) against five bacterial species at 10 microg/ml concentration and a significant activity (52%) against the same test bacteria at 25 microg/ml concentration.

  8. Topaz-II reactor control unit development

    SciTech Connect

    Wyant, F.J.; Jensen, D.; Logothetis, J.

    1994-12-31

    The development for a new digital reactor control unit for the Topaz-II reactor is described. The unit is expected to provide the means for automated control during a possible Topaz flight experiment. The breadboard design and development is discussed.

  9. Listening to Mothers II as a Catalyst.

    PubMed

    Grauer, Ann F

    2007-01-01

    The Listening to Mothers II report is not only a document; it is a tool that is accessible to childbirth educators. By becoming familiar with its contents, educators can use the information to help expectant parents think about options available to them and inspire them to use evidence-based information as they make choices for the birth of their child.

  10. African Americans and World War II.

    ERIC Educational Resources Information Center

    Kersten, Andrew E.

    2002-01-01

    Focuses on the experience of African Americans during World War II on the homefront and in the armed forces. States that African Americans not only fought fascism overseas but also apartheid in the United States, also known as the "Double V." (CMK)

  11. AIM-9X Block II Sidewinder (AIM-9X Blk II)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-442 AIM-9X Block II Sidewinder (AIM-9X Blk II) As of FY 2017 President’s Budget Defense...Program Office Estimate RDT&E - Research, Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be... Selective Availability Anti-Spoofing Module sec - seconds STD - Standard TV - Technical View AIM-9X Blk II December 2015 SAR March 23, 2016 15:14:10

  12. VELOCITY-RESOLVED [C ii] EMISSION AND [C ii]/FIR MAPPING ALONG ORION WITH HERSCHEL *,**

    PubMed Central

    Goicoechea, Javier R.; Teyssier, D.; Etxaluze, M.; Goldsmith, P.F.; Ossenkopf, V.; Gerin, M.; Bergin, E.A.; Black, J.H.; Cernicharo, J.; Cuadrado, S.; Encrenaz, P.; Falgarone, E.; Fuente, A.; Hacar, A.; Lis, D.C.; Marcelino, N.; Melnick, G.J.; Müller, H.S.P.; Persson, C.; Pety, J.; Röllig, M.; Schilke, P.; Simon, R.; Snell, R.L.; Stutzki, J.

    2015-01-01

    We present the first ~7.5′×11.5′ velocity-resolved (~0.2 km s−1) map of the [C ii] 158 μm line toward the Orion molecular cloud 1 (OMC 1) taken with the Herschel/HIFI instrument. In combination with far-infrared (FIR) photometric images and velocity-resolved maps of the H41α hydrogen recombination and CO J=2-1 lines, this data set provides an unprecedented view of the intricate small-scale kinematics of the ionized/PDR/molecular gas interfaces and of the radiative feedback from massive stars. The main contribution to the [C ii] luminosity (~85 %) is from the extended, FUV-illuminated face of the cloud (G0>500, nH>5×103 cm−3) and from dense PDRs (G≳104, nH≳105 cm−3) at the interface between OMC 1 and the H ii region surrounding the Trapezium cluster. Around ~15 % of the [C ii] emission arises from a different gas component without CO counterpart. The [C ii] excitation, PDR gas turbulence, line opacity (from [13C ii]) and role of the geometry of the illuminating stars with respect to the cloud are investigated. We construct maps of the L[C ii]/LFIR and LFIR/MGas ratios and show that L[C ii]/LFIR decreases from the extended cloud component (~10−2–10−3) to the more opaque star-forming cores (~10−3–10−4). The lowest values are reminiscent of the “[C ii] deficit” seen in local ultra-luminous IR galaxies hosting vigorous star formation. Spatial correlation analysis shows that the decreasing L[C ii]/LFIR ratio correlates better with the column density of dust through the molecular cloud than with LFIR/MGas. We conclude that the [C ii] emitting column relative to the total dust column along each line of sight is responsible for the observed L[C ii]/LFIR variations through the cloud. PMID:26568638

  13. VELOCITY-RESOLVED [C ii] EMISSION AND [C ii]/FIR MAPPING ALONG ORION WITH HERSCHEL(.)

    PubMed

    Goicoechea, Javier R; Teyssier, D; Etxaluze, M; Goldsmith, P F; Ossenkopf, V; Gerin, M; Bergin, E A; Black, J H; Cernicharo, J; Cuadrado, S; Encrenaz, P; Falgarone, E; Fuente, A; Hacar, A; Lis, D C; Marcelino, N; Melnick, G J; Müller, H S P; Persson, C; Pety, J; Röllig, M; Schilke, P; Simon, R; Snell, R L; Stutzki, J

    2015-10-10

    We present the first ~7.5'×11.5' velocity-resolved (~0.2 km s(-1)) map of the [C ii] 158 μm line toward the Orion molecular cloud 1 (OMC 1) taken with the Herschel/HIFI instrument. In combination with far-infrared (FIR) photometric images and velocity-resolved maps of the H41α hydrogen recombination and CO J=2-1 lines, this data set provides an unprecedented view of the intricate small-scale kinematics of the ionized/PDR/molecular gas interfaces and of the radiative feedback from massive stars. The main contribution to the [C ii] luminosity (~85 %) is from the extended, FUV-illuminated face of the cloud (G0>500, nH>5×10(3) cm(-3)) and from dense PDRs (G≳10(4), nH≳10(5) cm(-3)) at the interface between OMC 1 and the H ii region surrounding the Trapezium cluster. Around ~15 % of the [C ii] emission arises from a different gas component without CO counterpart. The [C ii] excitation, PDR gas turbulence, line opacity (from [(13)C ii]) and role of the geometry of the illuminating stars with respect to the cloud are investigated. We construct maps of the L[C ii]/LFIR and LFIR/MGas ratios and show that L[C ii]/LFIR decreases from the extended cloud component (~10(-2)-10(-3)) to the more opaque star-forming cores (~10(-3)-10(-4)). The lowest values are reminiscent of the "[C ii] deficit" seen in local ultra-luminous IR galaxies hosting vigorous star formation. Spatial correlation analysis shows that the decreasing L[C ii]/LFIR ratio correlates better with the column density of dust through the molecular cloud than with LFIR/MGas. We conclude that the [C ii] emitting column relative to the total dust column along each line of sight is responsible for the observed L[C ii]/LFIR variations through the cloud.

  14. R-MATRIX II Calculations for Electron Collisions with Ni II

    NASA Astrophysics Data System (ADS)

    Pradhan, Anil; Oelgoetz, Justin; Nahar, Sultana; Burke, V.; Burke, P.; Noble, C.

    2006-05-01

    The R-matrix II approach is especially designed to generate configuration-interaction expansions in a systematic manner, taking account of correlations due to one- two-, and three-electron excitations. The program package, PRMAT, is used to carry out heretofore the most elaborate electron scattering calculations for the astrophysically important ions Ni II and Fe II. Over 100 LS terms are included in the eigenfunction expansions, which yield good agreement with spectroscopically observed term energies. Large CI expansions are particularly important for accurate treatment of resonances that dominate the near-threshold behavior of collision strengths. Results are presented for a number transitions and compared with earlier works.

  15. Influence of different mineral and Organic pesticide treatments on Cd(II), Cu(II), Pb(II), and Zn(II) contents determined by derivative potentiometric stripping analysis in Italian white and red wines.

    PubMed

    Salvo, Francesco; La Pera, Lara; Di Bella, Giuseppa; Nicotina, Mariano; Dugo, Giacomo

    2003-02-12

    This paper deals with the use of derivative potentiometric stripping analysis (dPSA) as a rapid and precise method to determine Cd(II), Cu(II), Pb(II), and Zn(II) levels in red and white wine samples from Sicily, Campania, and Tuscany and to investigate the possible connection between the content of these metals and the pesticide treatments used in vine-growing to control plant diseases and pests. dPSA allowed direct quantitation of heavy metals in acidified wines without any sample pretreatment. Mean recoveries of Cd(II), Cu(II), Pb(II), and Zn(II) ranged from 95.5 to 99.2% for white wine samples and from 96.1 to 100.0% for red wine samples. The obtained results showed that Cd(II) was not found in any sample and that Cu(II), Pb(II), and Zn(II) levels were always lower than the toxicity limits in both fungicide- and water-treated wines. Nevertheless, the contents of metals were increased in samples from organic and inorganic pesticides treatment with respect to the water-treated samples. In particular, quinoxyfen, dinocap-penconazole, and dinocap applications considerably increased Cu(II) and Zn(II) contents in white and red wines. The levels of lead were significantly raised by azoxystrobin and sulfur treatments.

  16. Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-α-aminobutyric acid

    NASA Astrophysics Data System (ADS)

    Nair, M. Sivasankaran; Joseyphus, R. Selwin

    2008-09-01

    Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from vanillin and DL-α-aminobutyric acid were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, magnetic measurements, powder XRD and biological activity. The analytical data show the composition of the metal complex to be [ML(H 2O)], where L is the Schiff base ligand. The conductance data indicate that all the complexes are non-electrolytes. IR results demonstrate the tridentate binding of the Schiff base ligand involving azomethine nitrogen, phenolic oxygen and carboxylato oxygen atoms. The IR data also indicate the coordination of a water molecule with the metal ion in the complex. The electronic spectral measurements show that Co(II) and Ni(II) complexes have tetrahedral geometry, while Cu(II) complex has square planar geometry. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, whereas Ni(II) and Zn(II) complexes are crystalline in nature. Magnetic measurements show that Co(II), Ni(II) and Cu(II) complexes have paramagnetic behaviour. Antibacterial results indicated that the metal complexes are more active than the ligand.

  17. Simultaneous Stripping Detection of Pb(II), Cd(II) and Zn(II) Using a Bimetallic Hg-Bi/Single-Walled Carbon Nanotubes Composite Electrode

    PubMed Central

    Ouyang, Ruizhuo; Zhu, Zhenqian; Tatum, Clarissa E.; Chambers, James Q.; Xue, Zi-Ling

    2011-01-01

    A new, sensitive platform for the simultaneous electrochemical assay of Zn(II), Cd(II) and Pb(II) in aqueous solution has been developed. The platform is based on a new bimetallic Hg-Bi/single-walled carbon nanotubes (SWNTs) composite modified glassy carbon electrode (GCE), demonstrating remarkably improved performance for the anodic stripping assay of Zn(II), Cd(II) and Pb(II). The synergistic effect of Hg and Bi as well as the enlarged, activated surface and good electrical conductivity of SWNTs on GCE contribute to the enhanced activity of the proposed electrode. The analytical curves for Zn(II), Cd(II) an Pb(II) cover two linear ranges varying from 0.5 to 11 μg L-1 and 10 to 130 μg L-1 with correlation coefficients higher than 0.992. The limits of detection for Zn(II), Cd(II) are lower than 2 μg L-1 (S/N = 3). For Pb(II), moreover, there is another lower, linear range from 5 to 1100 ng L-1 with a coefficient of 0.987 and a detection limit of 0.12 ng L-1. By using the standard addition method, Zn(II), Cd(II) and Pb(II) ions in river samples were successfully determined. These results suggest that the proposed method can be applied as a simple, efficient alternative for the simultaneous monitoring of heavy metals in water samples. In addition, this method demonstrates the powerful application of carbon nanotubes in electrochemical analysis of heavy metals. PMID:21660117

  18. Sequestration of chelated copper by structural Fe(II): Reductive decomplexation and transformation of Cu(II)-EDTA.

    PubMed

    He, Hongping; Wu, Deli; Zhao, Linghui; Luo, Cong; Dai, Chaomeng; Zhang, Yalei

    2016-05-15

    Chelated coppers, such as Cu(II)-EDTA, are characteristically refractory and difficult to break down because of their high stability and solubility. Cu(II)-EDTA sequestration by structural Fe(II) (Fe(II)) was investigated intensively in this study. Up to 101.21mgCu(II)/gFe(II) was obtained by Fe(II) in chelated copper sequestration under near neutral pH condition (pH 7.70). The mechanism of Cu(II)-EDTA sequestration by Fe(II) was concluded as follows: 3Cu(II)-EDTA+7Fe(II)+9H2O → Cu(0)↓+ Cu2O↓(the major product)+2Fe2O3·H2O↓+3Fe(II)-EDTA +14H(+) Novel results strongly indicate that Cu(II) reductive transformation induced by surface Fe(II) was mainly responsible for chelated copper sequestration. Cu(0) generation was initially facilitated, and subsequent reduction of Cu(II) into Cu(I) was closely combined with the gradual increase of ORP (Oxidation-Reduction Potential). Cu-containing products were inherently stable, but Cu2O would be reoxidized to Cu(II) with extra-aeration, resulting in the release of copper, which was beneficial to Cu reclamation. Concentration diminution of Cu(II)-EDTA within the electric double layer and competitive adsorption were responsible for the negative effects of Ca(2+), Mg(2+). By generating vivianite, PO4(3-) was found to decrease surface Fe(II) content. This study is among the first ones to identify the indispensible role of reductive decomplexation in chelated copper sequestration. Given the high feasibility and reactivity, Fe(II) may provide a potential alternative in chelated metals pollution controlling.

  19. Zn(II) ions substantially perturb Cu(II) ion coordination in amyloid-β at physiological pH.

    PubMed

    Silva, K Ishara; Saxena, Sunil

    2013-08-15

    The interaction of Cu(II) and Zn(II) ions with amyloid-β (Aβ) plays an important role in the etiology of Alzheimer's disease. We describe the use of electron spin resonance (ESR) to measure metal-binding competition between Cu(II) and Zn(II) in amyloid-β at physiological pH. Continuous wave ESR measurements show that the affinity of Cu(II) toward Aβ(1-16) is significantly higher than that of Zn(II) at physiological pH. Importantly, of the two known Cu(II) coordination modes in Aβ, component I and component II, Zn(II) displaces Cu(II) only from component I. Our results indicate that at excess amounts of Zn(II) component II becomes the most dominant coordination mode. This observation is important as Aβ aggregates in the brain contain a high Zn(II) ion concentration. In order to determine details of the metal ion competition, electron spin echo envelope modulation experiments were carried out on Aβ variants that were systematically (15)N labeled. In the presence of Zn(II), most peptides use His 14 as an equatorial ligand to bind Cu(II) ions. Interestingly, Zn(II) ions completely substitute Cu(II) ions that are simultaneously coordinated to His 6 and His 13. Furthermore, in the presence of Zn(II), the proportion of Cu(II) ions that are simultaneously coordinated to His 13 and His 14 is increased. On the basis of our results we suggest that His 13 plays a critical role in modulating the morphology of Aβ aggregates.

  20. STRUCTURAL STUDIES ON A MITOCHONDRIAL GLYOXLASE II*

    PubMed Central

    Marasinghe, Gishanthi P. K.; Sander, Ian M.; Bennett, Brian; Periyannan, Gopalraj; Yang, Ke-Wu; Makaroff, Christopher A.; Crowder, Michael W.

    2005-01-01

    Glyoxalase 2 is a β-lactamase fold containing enzyme that appears to be involved with cellular chemical detoxification. Although the cytoplasmic isozyme has been characterized from several organisms, essentially nothing is known about the mitochondrial proteins. As a first step in understanding the structure and function of mitochondrial glyoxalase 2 enzymes, a mitochondrial isozyme (GLX2-5) from Arabidopsis thaliana was cloned, over-expressed, purified, and characterized using metal analyses, EPR and 1H NMR spectroscopies, and X-ray crystallography. The recombinant enzyme was shown to bind 1.04 ± 0.15 equivalents of iron, 1.31 ± 0.05 equivalents of Zn(II), and exhibit kcat and Km values of 129 ± 10 s−1 and 391 ± 48 μM, respectively, when using S-D-lactoylglutathione as the substrate. EPR spectra revealed that recombinant GLX2-5 contains multiple metal centers including a predominant Fe(III)Zn(II) center and an antiferromagnetically-coupled Fe(III)Fe(II) center. Unlike cytosolic glyoxalase 2 from A. thaliana, GLX2-5 does not appear to specifically bind manganese. 1H NMR spectra revealed the presence of at least 8 paramagnetically-shifted resonances that arise from protons in close proximity to a Fe(III)Fe(II) center. Five of these resonances arise from solvent exchangeable protons, and four of these have been assigned to NH protons on metal bound histidines. A 1.74 Å resolution crystal structure of the enzyme revealed that GLX2-5 is a dimeric protein with a metal center that is similar to that of human GLX2. These data demonstrate that mitochondrial glyoxalase 2 can accommodate a number of different metal centers and that the predominant metal center is Fe(III)Zn(II). PMID:16227621