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Sample records for ii na ii

  1. Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways in rats.

    PubMed

    Daniels, Derek; Mietlicki, Elizabeth G; Nowak, Erica L; Fluharty, Steven J

    2009-01-01

    Angiotensin II (AngII) stimulation of water and NaCl intake is a classic model of the behavioural effects of hormones. In vitro studies indicate that the AngII type 1 (AT(1)) receptor stimulates intracellular pathways that include protein kinase C (PKC) and mitogen-activated protein (MAP) kinase activation. Previous studies support the hypotheses that PKC is involved in AngII-induced water, but not NaCl intake and that MAP kinase plays a role in NaCl consumption, but not water intake, after injection of AngII. The present experiments test these hypotheses in rats using central injections of AngII in the presence or absence of a PKC inhibitor or a MAP kinase inhibitor. Pretreatment with the PKC inhibitor chelerythrine attenuated AngII-induced water intake, but NaCl intake was unaffected. In contrast, pretreatment with U0126, a MAP kinase inhibitor, had no effect on AngII-induced water intake, but attenuated NaCl intake. These data support the working hypotheses and significantly extend our earlier findings and those of others. Perhaps more importantly, these experiments demonstrate the remarkable diversity of peptide receptor systems and add support for the surprising finding that intracellular signalling pathways can have divergent behavioural relevance.

  2. Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway.

    PubMed

    Altairac, S; Zeggai, S; Perani, P; Courtois, Y; Torriglia, A

    2003-05-01

    L-DNase II is derived from its precursor leucocyte elastase inhibitor (LEI) by post-translational modification. In vitro, the conversion of LEI into L-DNase II can be induced by incubation of LEI at an acidic pH. In this study, we proposed to analyze the effects of intracellular acidification on this transformation. Amiloride derivatives, like hexamethylene amiloride (HMA), are known to provoke a decrease of cytosolic pH by inhibiting the Na(+)/H(+) antiport. In BHK cells, treatment with HMA-induced apoptosis accompanied by an increase in L-DNase II immunoreactivity and L-DNase II enzymatic activity. Overexpression of L-DNase II precursor led to a significant increase of apoptosis in these cells supporting the involvement of L-DNase II in HMA induced apoptosis. As previously shown in other cells, etoposide-induced apoptosis did not activate L-DNase. On the contrary, LEI overexpression significantly increased cell survival in etoposide-induced apoptosis. Together these results suggest differential roles of LEI and L-DNase II in response to different types of apoptotic inducers.

  3. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition.

    PubMed

    Nguyen, Mien T X; Lee, Donna H; Delpire, Eric; McDonough, Alicia A

    2013-08-15

    During angiotensin II (ANG II)-dependent hypertension, ANG II stimulates, while hypertension inhibits, Na(+) transporter activity to balance Na(+) output to input. This study tests the hypothesis that ANG II infusion activates Na(+) transporters in the distal nephron while inhibiting transporters along the proximal nephron. Male Sprague-Dawley rats were infused with ANG II (400 ng·kg(-1)·min(-1)) or vehicle for 2 wk. Kidneys were dissected (cortex vs. medulla) or fixed for immunohistochemistry (IHC). ANG II increased mean arterial pressure by 40 mmHg, urine Na(+) by 1.67-fold, and urine volume by 3-fold, evidence for hypertension and pressure natriuresis. Na(+) transporters' abundance and activation [assessed by phosphorylation (-P) or proteolytic cleavage] were measured by immunoblot. During ANG II infusion Na(+)/H(+) exchanger 3 (NHE3) abundance decreased in both cortex and medulla; Na-K-2Cl cotransporter 2 (NKCC2) decreased in medullary thick ascending loop of Henle (TALH) and increased, along with NKCC2-P, in cortical TALH; Na-Cl cotransporter (NCC) and NCC-P increased in the distal convoluted tubule; and epithelial Na(+) channel subunits and their cleaved forms were increased in both cortex and medulla. Like NKCC2, STE20/SPS1-related proline alanine-rich kinase (SPAK) and SPAK-P were decreased in medulla and increased in cortex. By IHC, during ANG II NHE3 remained localized to proximal tubule microvilli at lower abundance, and the differential regulation of NKCC2 and NKCC2-P in cortex versus medulla was evident. In summary, ANG II infusion increases Na(+) transporter abundance and activation from cortical TALH to medullary collecting duct while the hypertension drives a natriuresis response evident as decreased Na(+) transporter abundance and activation from proximal tubule through medullary TALH. PMID:23720346

  4. Tyrosinaemia II.

    PubMed

    Colditz, P B; Yu, J S; Billson, F A; Rogers, M; Molloy, H F; O'Halloran, M; Wilcken, B

    1984-08-18

    Four cases of tyrosinaemia type II (Richner-Hanhart syndrome) are reported. This syndrome consists of corneal erosions, palmar and plantar hyperkeratoses, and sometimes mental retardation. Presentation with photophobia and dendritic corneal ulceration or circumscribed palmoplantar keratoderma should alert the physician to the possible diagnosis of tyrosinaemia II. Early diagnosis is important, as the clinical picture can be modified by dietary restriction.

  5. Biosorption of toxic lead (II) ions using tomato waste (Solanum lycopersicum) activated by NaOH

    NASA Astrophysics Data System (ADS)

    Permatasari, Diah; Heraldy, Eddy; Lestari, Witri Wahyu

    2016-02-01

    This research present to uptake lead (II) ion from aqueous solutions by activated tomato waste. Biosorbent were characterized by applying Fourier Transform Infrared Spectroscopy (FTIR) and Surface Area Analyzer (SAA). The biosorption investigated with parameters including the concentration of NaOH, effects of solution pH, biosorbent dosage, contact time,and initial metal concentration. Experimental data were analyzed in terms of two kinetic model such us the pseudo-first order and pseudo-second order. Langmuir and Freundlich isotherm models were applied todescribe the biosorption process. According to the experiment, the optimum concentration of NaOH was achieved at 0.1 M. The maximum % lead (II) removal was achieved at pH 4 with 94.5%. Optimum biosorbentdosage were found as 0.1 g/25 mL solution while optimum contact time were found at 75 minutes. The results showed that the biosorption processes of Lead (II) followed pseudo-second order kinetics. Langmuir adsorption isotherm was found fit the adsorption data with amaximum capacity of 24.079 mg/g with anadsorption energy of 28.046 kJ/mol.

  6. Crystal structure and magnetic properties of NaCu{sup II}[(Cu{sup II}{sub 3}O)(PO{sub 4}){sub 2}Cl

    SciTech Connect

    Jin Tengteng; Liu Wei; Chen Shuang; Prots, Yurii; Schnelle, Walter; Zhao Jingtai; Kniep, Ruediger; Hoffmann, Stefan

    2012-08-15

    A new copper(II) oxide phosphate chloride, NaCu{sup II}[(Cu{sup II}{sub 3}O)(PO{sub 4}){sub 2}Cl], has been synthesized by flux synthesis. Single-crystal X-ray diffraction data show that the title compound crystallizes in the monoclinic system, space group P2{sub 1}/c (No. 14), with lattice parameters a=8.392(2) A, b=6.3960(10) A, c=16.670(2) A, {beta}=109.470(10) Degree-Sign , V=843.6(3) A{sup 3}, Z=4. The crystal structure is characterized by a complex chain of copper-centered polyhedra running along [0 1 0] which are connected by phosphate tetrahedra. The resulting three-dimensional polyhedra framework exhibits channels filled by additional copper and sodium atoms. Field and temperature dependent measurements of the specific heat and the magnetic susceptibility reveal low-dimensional magnetic behavior. The compound starts to decompose at 700 K under release of oxygen and evaporation of Cu{sup I}Cl as shown by simultaneous thermogravimetry and mass spectrometry. - Graphical abstract: The crystal structure of the new copper(II) phosphate chloride, NaCu{sup II}[(Cu{sup II}{sub 3}O)(PO{sub 4}){sub 2}Cl], exhibits linear chains of copper tetrahedra which show low-dimensional magnetic behavior proven by specific heat and magnetic susceptibility measurements. Highlights: Black-Right-Pointing-Pointer A new copper(II) oxide phosphate chloride, NaCu{sup II}[(Cu{sup II}{sub 3}O)(PO{sub 4}){sub 2}Cl], has been synthesized by flux synthesis. Black-Right-Pointing-Pointer The crystal structure comprises chains of Cu{sub 4}O tetrahedra. Black-Right-Pointing-Pointer Low-dimensional behavior has been proven by magnetic and specific heat measurements. Black-Right-Pointing-Pointer On heating, Cu{sup I}Cl and oxygen are released shown by simultaneous thermogravimetry and mass spectrometry.

  7. Photosystem II

    ScienceCinema

    James Barber

    2016-07-12

    James Barber, Ernst Chain Professor of Biochemistry at Imperial College, London, gives a BSA Distinguished Lecture titled, "The Structure and Function of Photosystem II: The Water-Splitting Enzyme of Photosynthesis."

  8. Biosorption of lead (II) ions by NaOH-activated apple (Malus domestica) juice residue

    NASA Astrophysics Data System (ADS)

    Arimurti, Devita Dwi; Heraldy, Eddy; Lestari, Witri Wahyu

    2016-02-01

    This research studied the removal of Pb(II) ions from aqueous solutions using NaOH-activated apple (Malus domestica) juice residue. Biosorbent was characterized with Fourier Transform Infrared Spectrophotometer (FTIR), and Surface Area Analyzer (SAA). The effects of biosorbent dosage, pH, contact time and initial metal ion concentration had been investigated in batch-adsorption method. The biosorption kinetic data were analyzed by pseudo-first-order and pseudo-second-order kinetics model. Freundlich and Langmuir's isotherm were used to describe the biosorption process. The optimum conditions of Pb(II) adsorption was observed at 60 min of contact time, pH 4, and 0.1 g biosorbent dosage in 25 ml solution. The biosorption kinetics followed the pseudo-second-order kinetic model, resulted biosorption constant rate of 0.184 g.mg-1.min-1. The Langmuir isotherm model exhibited the best fit to experimental data. The maximum biosorption capacity of Pb(II) determined according to the Langmuir model was 90.90 mg.g-1 at 302 K, with the adsorption energy of 26.429 kJ.mol-1.

  9. Angiotensin II receptor signalling.

    PubMed

    Daniels, Derek; Yee, Daniel K; Fluharty, Steven J

    2007-05-01

    Angiotensin II plays a key role in the regulation of body fluid homeostasis. To correct body fluid deficits that occur during hypovolaemia, an animal needs to ingest both water and electrolytes. Thus, it is not surprising that angiotensin II, which is synthesized in response to hypovolaemia, acts centrally to increase both water and NaCl intake. Here, we review findings relating to the properties of angiotensin II receptors that give rise to changes in behaviour. Data are described to suggest that divergent signal transduction pathways are responsible for separable behavioural responses to angiotensin II, and a hypothesis is proposed to explain how this divergence may map onto neural circuits in the brain.

  10. Novel Cu(II)-M(II)-Cu(II) (M = Cu or Ni) trinuclear and [NaCu] hexanuclear complexes assembled by bi-compartmental ligands: syntheses, structures, magnetic and catalytic studies.

    PubMed

    Biswas, Surajit; Dutta, Arpan; Dolai, Malay; Bhowmick, Indrani; Rouzières, Mathieu; Clérac, Rodolphe; Panja, Anangamohan; Ali, Mahammad

    2015-05-28

    In the present work, two compartmental ligands H2L(1) and H2L(2) were in situ generated during the syntheses of new trinuclear complexes, [Cu2Ni(L(1))(2,2'-bpy)2(NO3)2][ClO4]2 (), [Cu3(L(2))(NO3)2][ClO4]2 (), and [Cu3(L(2))(NCS)2(NO3)](+) that co-crystallize in with a [Cu6(L(2))2Na2(NO3)6(NCS)4] unit to give the final molecular formula [Cu6(L(2))2Na2(NO3)6(NCS)4][Cu3(L(2))(NCS)2(NO3)]2(NO3)2·5H2O (). The magnetic property studies of revealed weak Cu(II)-Cu(II) ferromagnetic interactions in compound (JCu-Cu/kB = +1.4(1) K) and (JCu-Cu/kB = +1.6) while in intranuclear Cu(II)-Ni(II)-Cu(II) compound , the magnetic coupling between two Cu(II) ions is switched off by the diamagnetic square planar Ni(II) bridge. The catalytic epoxidation of two olefins, namely styrene and cyclooctene, by tert-BuOOH (TBHP) was also explored in the presence of a catalytic amount of , or in MeCN. For styrene oxidation, exhibited ∼57% styrene epoxide selectively (conversion ∼37%) with a TON of about 925 along with benzaldehyde (∼43%), whereas exhibited conversion up to ∼63% (TON ∼ 1575) with a good selectivity towards epoxide (∼71%). For compound , this conversion is more important (TON ∼ 8108) probably due to the presence of more active sites involved in the epoxidation. The concerted path was found to be operative for styrene oxidation while a radical path was suggested for the oxidation of cyclooctene.

  11. SAGE II

    Atmospheric Science Data Center

    2016-02-16

    ... of stratospheric aerosols, ozone, nitrogen dioxide, water vapor and cloud occurrence by mapping vertical profiles and calculating ... (i.e. MLS and SAGE III versus HALOE) Fixed various bugs Details are in the  SAGE II V7.00 Release Notes .   ...

  12. PORT II

    NASA Technical Reports Server (NTRS)

    Muniz, Beau

    2009-01-01

    One unique project that the Prototype lab worked on was PORT I (Post-landing Orion Recovery Test). PORT is designed to test and develop the system and components needed to recover the Orion capsule once it splashes down in the ocean. PORT II is designated as a follow up to PORT I that will utilize a mock up pressure vessel that is spatially compar able to the final Orion capsule.

  13. BORE II

    2015-08-01

    Bore II, co-developed by Berkeley Lab researchers Frank Hale, Chin-Fu Tsang, and Christine Doughty, provides vital information for solving water quality and supply problems and for improving remediation of contaminated sites. Termed "hydrophysical logging," this technology is based on the concept of measuring repeated depth profiles of fluid electric conductivity in a borehole that is pumping. As fluid enters the wellbore, its distinct electric conductivity causes peaks in the conductivity log that grow and migratemore » upward with time. Analysis of the evolution of the peaks enables characterization of groundwater flow distribution more quickly, more cost effectively, and with higher resolution than ever before. Combining the unique interpretation software Bore II with advanced downhole instrumentation (the hydrophysical logging tool), the method quantifies inflow and outflow locations, their associated flow rates, and the basic water quality parameters of the associated formation waters (e.g., pH, oxidation-reduction potential, temperature). In addition, when applied in conjunction with downhole fluid sampling, Bore II makes possible a complete assessment of contaminant concentration within groundwater.« less

  14. BORE II

    SciTech Connect

    2015-08-01

    Bore II, co-developed by Berkeley Lab researchers Frank Hale, Chin-Fu Tsang, and Christine Doughty, provides vital information for solving water quality and supply problems and for improving remediation of contaminated sites. Termed "hydrophysical logging," this technology is based on the concept of measuring repeated depth profiles of fluid electric conductivity in a borehole that is pumping. As fluid enters the wellbore, its distinct electric conductivity causes peaks in the conductivity log that grow and migrate upward with time. Analysis of the evolution of the peaks enables characterization of groundwater flow distribution more quickly, more cost effectively, and with higher resolution than ever before. Combining the unique interpretation software Bore II with advanced downhole instrumentation (the hydrophysical logging tool), the method quantifies inflow and outflow locations, their associated flow rates, and the basic water quality parameters of the associated formation waters (e.g., pH, oxidation-reduction potential, temperature). In addition, when applied in conjunction with downhole fluid sampling, Bore II makes possible a complete assessment of contaminant concentration within groundwater.

  15. Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties

    PubMed Central

    Lee, Donna H.; Maunsbach, Arvid B.; Riquier-Brison, Anne D.; Nguyen, Mien T. X.; Fenton, Robert A.; Bachmann, Sebastian; Yu, Alan S.

    2013-01-01

    The renal distal tubule Na-Cl cotransporter (NCC) reabsorbs <10% of the filtered Na+ but is a key control point for blood pressure regulation by angiotensin II (ANG II), angiotensin-converting enzyme inhibitors (ACEI), and thiazide diuretics. This study aimed to determine whether NCC phosphorylation (NCCp) was regulated by acute (20–30 min) treatment with the ACEI captopril (12 μg/min × 20 min) or by a sub-pressor dose of ANG II (20 ng·kg−1·min−1) in Inactin-anesthetized rats. By immuno-EM, NCCp was detected exclusively in or adjacent to apical plama membranes (APM) in controls and after ACEI or ANG II treatment, while NCC total was detected in both APM and subapical cytoplasmic vesicles (SCV) in all conditions. In renal homogenates, neither ACEI nor ANG II treatment altered NCCp abundance, assayed by immunoblot. However, by density gradient fractionation we identified a pool of low-density APM in which NCCp decreased 50% in response to captopril and was restored during ANG II infusion, and another pool of higher-density APM that responded reciprocally, indicative of regulated redistribution between two APM pools. In both pools, NCCp was preferentially localized to Triton-soluble membranes. Blue Native gel electrophoresis established that APM NCCp localized to ∼700 kDa complexes (containing γ-adducin) while unphosphorylated NCC in intracellular membranes primarily localized to ∼400 kDa complexes: there was no evidence for native monomeric or dimeric NCC or NCCp. In summary, this study demonstrates that phosphorylated NCC, localized to multimeric complexes in the APM, redistributes in a regulated manner within the APM in response to ACEI and ANG II. PMID:23114965

  16. Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.

    PubMed

    He, Peijian; Klein, Janet; Yun, C Chris

    2010-09-01

    Angiotensin II (ANG II) stimulates renal tubular reabsorption of NaCl by targeting Na(+)/H(+) exchanger NHE3. We have shown previously that inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) plays a critical role in stimulation of NHE3 in response to elevated intracellular Ca(2+) concentration ([Ca(2+)](i)). In this study, we investigated the role of IRBIT in mediating NHE3 activation by ANG II. IRBIT is abundantly expressed in the proximal tubules where NHE3 is located. ANG II at physiological concentrations stimulates NHE3 transport activity in a model proximal tubule cell line. ANG II-induced activation of NHE3 was abrogated by knockdown of IRBIT, whereas overexpression of IRBIT enhanced the effect of ANG II on NHE3. ANG II transiently increased binding of IRBIT to NHE3 at 5 min but became dissociated by 45 min. In comparison, it took at least 15 min of ANG II treatment for an increase in NHE3 activity and NHE3 surface expression. The stimulation of NHE3 by ANG II was dependent on changes in [Ca(2+)](i) and Ca(2+)/calmodulin-dependent protein kinases II. Inhibition of CaMKII completely blocked the ANG II-induced binding of IRBIT to NHE3 and the increase in NHE3 surface abundance. Several serine residues of IRBIT are thought to be important for IRBIT binding. Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity. In conclusion, our current findings demonstrate that IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway.

  17. Ca II and Na I absorption signatures from extraplanar gas in the halo of the Milky Way

    NASA Astrophysics Data System (ADS)

    Ben Bekhti, N.; Richter, P.; Westmeier, T.; Murphy, M. T.

    2008-08-01

    Aims: We analyse absorption characteristics and physical conditions of extraplanar intermediate- and high-velocity gas to study the distribution of the neutral and weakly ionised Milky Way halo gas and its relevance for the evolution of the Milky Way and other spiral galaxies. Methods: We combine optical absorption line measurements of Ca II/Na I and 21 cm emission line observations of H I along 103 extragalactic lines of sight towards quasars (QSOs) and active galactic nuclei (AGN). The archival optical spectra were obtained with the Ultraviolet and Visual Echelle Spectrograph (UVES) at the ESO Very Large Telescope, while the 21 cm H I observations were carried out using the 100-m radio telescope at Effelsberg. Results: The analysis of the UVES spectra shows that single and multi-component Ca II/Na I absorbers at intermediate and high velocities are present in about 35 percent of the sight lines, indicating the presence of neutral extraplanar gas structures. In some cases the Ca II/Na I absorption is connected with H I 21 cm intermediate- or high-velocity gas with H I column densities in the range of 1018 to 1020 cm-2 (i.e., the classical IVCs and HVCs), while other Ca II/Na I absorbers show no associated H I emission. The observed H I line widths vary from Δ vFWHM=3.2 km s-1 to 32.0 km s-1 indicating a range of upper gas temperature limits of 250 K up to about 22 500 K. Conclusions: Our study suggests that the Milky Way halo is filled with a large number of neutral gaseous structures whose high column density tail represents the population of common H I high-velocity clouds seen in 21 cm surveys. The Ca II column density distribution follows a power-law f(N)=CNβ with a slope of β ≈ -1.6, thus comparable to the distribution found for intervening metal-line systems toward QSOs. Many of the statistical and physical properties of the Ca II absorbers resemble those of strong (W_λ 2796>0.3 Å) Mg II absorbing systems observed in the circumgalactic environment of

  18. Synthesis and spectroscopic studies of novel Cu(II), Co(II), Ni(II) and Zn(II) mixed ligand complexes with saccharin and nicotinamide

    NASA Astrophysics Data System (ADS)

    Çakır, S.; Bulut, İ.; Naumov, P.; Biçer, E.; Çakır, O.

    2001-01-01

    Four novel mixed ligand complexes of Cu(II), Co(II), Ni(II) and Zn(II) with saccharin and nicotinamide were synthesised and characterised on the basis of elemental analysis, FT-IR spectroscopic study, UV-Vis spectrometric and magnetic susceptibility data. The structure of the Cu (II) complex is completely different from those of the Co(II), Ni(II) and Zn(II) complexes. From the frequencies of the saccharinato CO and SO 2 modes, it has been proven that the saccharinato ligands in the structure of the Cu complex are coordinated to the metal ion ([Cu(NA) 2(Sac) 2(H 2O)], where NA — nicotinamide, Sac — saccharinato ligand or ion), whilst in the Co(II), Ni(II) and Zn(II) complexes are uncoordinated and exist as ions ([M(NA) 2(H 2O) 4](Sac) 2).

  19. Temporal Lobe Epilepsy Induces Intrinsic Alterations in Na Channel Gating in Layer II Medial Entorhinal Cortex Neurons

    PubMed Central

    Hargus, Nicholas J.; Merrick, Ellen C.; Nigam, Aradhya; Kalmar, Christopher L.; Baheti, Aparna R.; Bertram, Edward H.; Patel, Manoj K.

    2010-01-01

    Temporal lobe epilepsy (TLE) is the most common form of adult epilepsy involving the limbic structures of the temporal lobe. Layer II neurons of the entorhinal cortex (EC) form the major excitatory input into the hippocampus via the perforant path and consist of non-stellate and stellate neurons. These neurons are spared and hyper-excitable in TLE. The basis for the hyper-excitability is likely multifactorial and may include alterations in intrinsic properties. In a rat model of TLE, medial EC (mEC) non-stellate and stellate neurons had significantly higher action potential (AP) firing frequencies than in control. The increase remained in the presence of synaptic blockers, suggesting intrinsic mechanisms. Since sodium (Na) channels play a critical role in AP generation and conduction we sought to determine if Na channel gating parameters and expression levels were altered in TLE. Na channel currents recorded from isolated mEC TLE neurons revealed increased Na channel conductances, depolarizing shifts in inactivation parameters and larger persistent (INaP) and resurgent (INaR) Na currents. Immunofluorescence experiments revealed increased staining of Nav1.6 within the axon initial segment and Nav1.2 within the cell bodies of mEC TLE neurons. These studies provide support for additional intrinsic alterations within mEC layer II neurons in TLE and implicate alterations in Na channel activity and expression, in part, for establishing the profound increase in intrinsic membrane excitability of mEC layer II neurons in TLE. These intrinsic changes, together with changes in the synaptic network, could support seizure activity in TLE. PMID:20946956

  20. A comparative study for the ion exchange of Fe(III) and Zn(II) on zeolite NaY.

    PubMed

    Ostroski, Indianara C; Barros, Maria A S D; Silva, Edson A; Dantas, João H; Arroyo, Pedro A; Lima, Oswaldo C M

    2009-01-30

    The uptake capacity of Fe(III) and Zn(II) ions in NaY zeolite was investigated. Experiments were carried out in a fixed bed column at 30 degrees C, pH 3.5 and 4.5 for Fe(III) and Zn(II), respectively, and an average particle size of 0.180 mm. In order to minimize the diffusional resistances the influence of flow rate on the breakthrough curves at feed concentrations of 1.56 meq/L for Fe(III) and 0.844 meq/L for Zn(II) was investigated. Flow rate of the minimal resistance in the bed according to mass transfer parameter were 2.0 mL/min for iron and 8.0 mL/min for zinc ions. Freundlich and Langmuir isotherm models have been used to represent the column equilibrium data. The iron dynamic isotherm was successfully modeled by the Langmuir equation and this mathematical model described well the experimental breakthrough curves for feed concentrations from 0.1 up to 3.5 meq/L. The zinc dynamic isotherm was successfully modeled by the Freundlich equation. This equilibrium model was applied to mathematical model. Experimental breakthrough curves could be predicted. Experiments were also carried out in a batch reactor to investigate the kinetics adsorption of the ions Fe(III) and Zn(II). Langmuir kinetic model fit well both experimental data.

  1. Dietary NaC1 during pregnancy and lactation: effect on brain angiotensin II receptors and behavior.

    PubMed

    Rowland, N E; Crews, E C; Young, S L; Speth, R C

    1999-10-01

    Female rats were fed diets containing either a basal (0.12%), mid- (1%) or high (3%) level of NaCl during pregnancy and lactation. Plasma aldosterone was elevated approximately 5- and 15-fold in dams fed basal compared with either the mid- or high-NaCl diets at the end of both pregnancy and lactation (Postnatal Day 21), respectively. Dams fed basal diet and killed at the end of lactation had a higher density of angiotensin II receptors in the organum vasculosum laminae terminalis, paraventricular hypothalamus, and median preoptic nucleus than did rats fed either mid- or high-NaCl diets. Other dams, treated identically, were returned to rodent chow (approximately 0.2% NaCl) at the end of lactation for intake tests during the next week. Dams that had received basal diet did not differ from mid-NaCl and high-NaCl groups in sodium appetite induced by either acute sodium depletion or mineralocorticoid administration but showed the lowest spontaneous intake of NaCl solution.

  2. Diffusion of Na(I), Cs(I), Sr(II) and Eu(III) in smectite rich natural clay.

    PubMed

    Kasar, Sharayu; Kumar, Sumit; Bajpai, R K; Tomar, B S

    2016-01-01

    Diffusion of Na(I), Cs(I), Sr(II) and Eu(III) in smectite rich natural clay, proposed as a backfill material in the Indian geological repository, was studied using the out-diffusion method. Radiotracers (22)Na, (137)Cs, (85)Sr and (154)Eu were used; the first three are carrier-free enabling experimental work at sub-micromolar metal ion concentration, and Eu(III) tracer (154)Eu was used at sub millimolar concentration. An out-diffusion methodology, wherein a thin planar source of radioactivity placed between two clay columns diffuses out, was used to obtain the apparent diffusion coefficient (Da) values. This methodology enabled determination of diffusion coefficient even for strongly sorbing (154)Eu. Da values for (22)Na, (137)Cs, (85)Sr and (154)Eu were 2.35 (±0.14) × 10(-11), 2.65 (±0.09) × 10(-12), 3.32 (±0.15) × 10(-11) and 1.23 (±0.15) × 10(-13) m(2) s(-1), respectively. Da values were found to be in fair agreement with literature data reported for similar mineralogical sediments. Sorption of radionuclides on the clay was also determined in the present study and differences in Da values were rationalized on the basis of sorption data. Distribution ratios (Kd) for Cs(I) and Eu(III) were higher than that for Sr(II), which in turn was higher than that for Na(I).

  3. Phosphorylation of rat kidney Na-K pump at Ser938 is required for rapid angiotensin II-dependent stimulation of activity and trafficking in proximal tubule cells.

    PubMed

    Massey, Katherine J; Li, Quanwen; Rossi, Noreen F; Keezer, Susan M; Mattingly, Raymond R; Yingst, Douglas R

    2016-02-01

    How angiotensin (ANG) II acutely stimulates the Na-K pump in proximal tubules is only partially understood, limiting insight into how ANG II increases blood pressure. First, we tested whether ANG II increases the number of pumps in plasma membranes of native rat proximal tubules under conditions of rapid activation. We found that exposure to 100 pM ANG II for 2 min, which was previously shown to increase affinity of the Na-K pump for Na and stimulate activity threefold, increased the amount of the Na-K pump in plasma membranes of native tubules by 33%. Second, we tested whether previously observed increases in phosphorylation of the Na-K pump at Ser(938) were part of the stimulatory mechanism. These experiments were carried out in opossum kidney cells, cultured proximal tubules stably coexpressing the ANG type 1 (AT1) receptor, and either wild-type or a S938A mutant of rat kidney Na-K pump under conditions found by others to stimulate activity. We found that 10 min of incubation in 10 pM ANG II stimulated activity of wild-type pumps from 2.3 to 3.5 nmol K · mg protein(-1) · min(-1) and increased the amount of the pump in the plasma membrane by 80% but had no effect on cells expressing the S938A mutant. We conclude that acute stimulation of Na-K pump activity in native rat proximal tubules includes increased trafficking to the plasma membrane and that phosphorylation at Ser(938) is part of the mechanism by which ANG II directly stimulates activity and trafficking of the rat kidney Na-K pump in opossum kidney cells. PMID:26582472

  4. Phosphorylation of rat kidney Na-K pump at Ser938 is required for rapid angiotensin II-dependent stimulation of activity and trafficking in proximal tubule cells.

    PubMed

    Massey, Katherine J; Li, Quanwen; Rossi, Noreen F; Keezer, Susan M; Mattingly, Raymond R; Yingst, Douglas R

    2016-02-01

    How angiotensin (ANG) II acutely stimulates the Na-K pump in proximal tubules is only partially understood, limiting insight into how ANG II increases blood pressure. First, we tested whether ANG II increases the number of pumps in plasma membranes of native rat proximal tubules under conditions of rapid activation. We found that exposure to 100 pM ANG II for 2 min, which was previously shown to increase affinity of the Na-K pump for Na and stimulate activity threefold, increased the amount of the Na-K pump in plasma membranes of native tubules by 33%. Second, we tested whether previously observed increases in phosphorylation of the Na-K pump at Ser(938) were part of the stimulatory mechanism. These experiments were carried out in opossum kidney cells, cultured proximal tubules stably coexpressing the ANG type 1 (AT1) receptor, and either wild-type or a S938A mutant of rat kidney Na-K pump under conditions found by others to stimulate activity. We found that 10 min of incubation in 10 pM ANG II stimulated activity of wild-type pumps from 2.3 to 3.5 nmol K · mg protein(-1) · min(-1) and increased the amount of the pump in the plasma membrane by 80% but had no effect on cells expressing the S938A mutant. We conclude that acute stimulation of Na-K pump activity in native rat proximal tubules includes increased trafficking to the plasma membrane and that phosphorylation at Ser(938) is part of the mechanism by which ANG II directly stimulates activity and trafficking of the rat kidney Na-K pump in opossum kidney cells.

  5. Angiotensin II AT1 receptor stimulates Na+–K+ ATPase activity through a pathway involving PKC-ζ in rat thyroid cells

    PubMed Central

    Marsigliante, S; Muscella, A; Elia, M G; Greco, S; Storelli, C

    2003-01-01

    Angiotensin II (Ang II) receptor subtype 1, AT1, is expressed by the rat thyroid. A relationship between thyroid function and several components of the renin-angiotensin system has also been established, but the Ang II cellular effects in thyrocytes and its transduction signalling remain undefined. The aim of the present paper was to investigate the modulation of the activity of the Na+-K+ ATPase by Ang II and its intracellular transduction pathway in PC-Cl3 cells, an established epithelial cell line derived from rat thyroid. Here we have demonstrated, by RT-PCR analysis, the expression of mRNA for the Ang II AT1 receptor in PC-Cl3 cells; mRNA for the Ang II AT2 receptor was not detected. Ang II was not able to affect the intracellular Ca2+ concentration in fura-2-loaded cells, but it stimulated the translocation from the cytosol to the plasma membrane of atypical protein kinase C-zeta (PKC-ζ) and -iota (PKC-ι) isoforms with subsequent phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1 and 2). Translocated atypical PKCs displayed temporally different activations, the activation of PKC-ζ being the fastest. PC-Cl3 cells stimulated with increasing Ang II concentrations showed dose- and time-dependent activation of the Na+-K+ ATPase activity, which paralleled the PKC-ζ translocation time course. Na+-K+ ATPase activity modulation was dependent on PKC activation since the PKC antagonist staurosporine abolished the stimulatory effect of Ang II. The inhibition of the ERK kinases 1 and 2 (MEK1 and 2) by PD098059 (2′-amino-3′-methoxyflavone) failed to block the effect of Ang II on the Na+-K+ ATPase activity. In conclusion, our results suggest that Ang II modulates Na+-K+ ATPase activity in PC-Cl3 cells through the AT1 receptor via activation of atypical PKC-ζ while the Ang II-activated PKC-ζ appears to have other as yet unknown functions. PMID:12527732

  6. The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.

    PubMed

    He, Peijian; Zhao, Luqing; No, Yi Ran; Karvar, Serhan; Yun, C Chris

    2016-08-01

    Na(+)/H(+) exchanger (NHE)3, a major Na(+) transporter in the luminal membrane of the proximal tubule, is subject to ANG II regulation in renal Na(+)/fluid absorption and blood pressure control. We have previously shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells. In searching for scaffold protein(s) that coordinates with IRBIT in NHE3 trafficking, we found that NHE regulatory factor (NHERF)1, NHE3, and IRBIT proteins were coexpressed in the same macrocomplexes and that loss of ANG II type 1 receptors decreased their expression in the renal brush-border membrane. We found that NHERF1 was required for ANG II-mediated forward trafficking and activation of NHE3 in cultured cells. ANG II induced a concomitant increase of NHERF1 interactions with NHE3 and IRBIT, which were abolished when the NHERF1 PDZ1 domain was removed. Overexpression of a yellow fluorescent protein-NHERF1 construct that lacks PDZ1, but not PDZ2, failed to exaggerate the ANG II-dependent increase of NHE3 expression in the apical membrane. Moreover, exogenous expression of PDZ1 exerted a dominant negative effect on NHE3 activation by ANG II. We further demonstrated that IRBIT was indispensable for the ANG II-provoked increase in NHERF1-NHE3 interactions and that phosphorylation of IRBIT at Ser(68) was necessary for the assembly of the NHEF1-IRBIT-NHE3 complex. Taken together, our findings suggest that NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3. PMID:27279487

  7. Ca II AND Na I QUASAR ABSORPTION-LINE SYSTEMS IN AN EMISSION-SELECTED SAMPLE OF SDSS DR7 GALAXY/QUASAR PROJECTIONS. I. SAMPLE SELECTION

    SciTech Connect

    Cherinka, B.; Schulte-Ladbeck, R. E.

    2011-10-15

    The aim of this project is to identify low-redshift host galaxies of quasar absorption-line systems by selecting galaxies that are seen in projection onto quasar sightlines. To this end, we use the Seventh Data Release of the Sloan Digital Sky Survey to construct a parent sample of 97,489 galaxy/quasar projections at impact parameters of up to 100 kpc to the foreground galaxy. We then search the quasar spectra for absorption-line systems of Ca II and Na I within {+-}500 km s{sup -1} of the galaxy's velocity. This yields 92 Ca II and 16 Na I absorption systems. We find that most of the Ca II and Na I systems are sightlines through the Galactic disk, through high-velocity cloud complexes in our halo, or Virgo Cluster sightlines. Placing constraints on the absorption line rest equivalent width significance ({>=}3.0{sigma}), the local standard of rest velocity along the sightline ({>=}345 km s{sup -1}), and the ratio of the impact parameter to the galaxy optical radius ({<=}5.0), we identify four absorption-line systems that are associated with low-redshift galaxies at high confidence, consisting of two Ca II systems (one of which also shows Na I) and two Na I systems. These four systems arise in blue, {approx}L*{sub r} galaxies. Tables of the 108 absorption systems are provided to facilitate future follow-up.

  8. FIRE II - Cirrus Data Sets

    Atmospheric Science Data Center

    2013-07-26

    FIRE II - Cirrus Data Sets First ISCCP Regional Experiment (FIRE) II ... stratocumulus systems, the radiative properties of these clouds and their interactions. Relevant Documents:  FIRE Project Guide FIRE II - Cirrus Home Page FIRE II - Cirrus Mission Summaries ...

  9. Ouabain binding in tadpole ventral skin II. Localization of Na pump sites

    SciTech Connect

    Robinson, D.H.; Mills, J.W. )

    1987-09-01

    By use of ({sup 3}H)ouabain autoradiography, the distribution of ouabain binding sites in the tadpole ventral skin and the change in the pattern of binding during metamorphosis were examined. In the tadpole the greatest grain density, one hence density of Na pumps, was found in the outer one-third of the epidermis. The pattern of binding changed at stage 20 to a homogeneous distribution. At stage 21 the highest grain density was in the middle third of the epidermis. The adult-like pattern of binding, with the highest density in the serosal two-thirds of the epidermis, was noted at stages 22 and 23. The average grain density through the entire tissue is {approximately}2.4-fold higher in the stage 23 animal than in the tadpole with the significant increase in density occurring between stages 20 and 21. Since the adult Na transport characteristics are also not fully developed until stage 22, it is proposed that the development of the Na-pump characteristics is coincident with the development of other adult transport properties.

  10. Type II universal spacetimes

    NASA Astrophysics Data System (ADS)

    Hervik, S.; Málek, T.; Pravda, V.; Pravdová, A.

    2015-12-01

    We study type II universal metrics of the Lorentzian signature. These metrics simultaneously solve vacuum field equations of all theories of gravitation with the Lagrangian being a polynomial curvature invariant constructed from the metric, the Riemann tensor and its covariant derivatives of an arbitrary order. We provide examples of type II universal metrics for all composite number dimensions. On the other hand, we have no examples for prime number dimensions and we prove the non-existence of type II universal spacetimes in five dimensions. We also present type II vacuum solutions of selected classes of gravitational theories, such as Lovelock, quadratic and L({{Riemann}}) gravities.

  11. Microscopic level investigation of Ni(II) sorption on Na-rectorite by EXAFS technique combined with statistical F-tests.

    PubMed

    Ren, Xuemei; Yang, Shitong; Hu, Fengchun; He, Bo; Xu, Jinzhang; Tan, Xiaoli; Wang, Xiangke

    2013-05-15

    Extended X-ray absorption fine structure (EXAFS) spectroscopy combined with statistical F-tests is used to investigate the local atomic structures of Ni(II) adsorbed on Na-rectorite. The EXAFS analysis results of Ni(II) sorption samples indicate that the first coordination shell consists of ~6 O at the Ni-O interatomic distance (R) of ~2.04 Å. The presence of Ni backscattering at R(Ni-Ni) = 3.06 Å in the second coordination shell suggests the formation of Ni(II) precipitate. The results of F-tests show that the Ni(II) precipitate is Ni-Al layered double hydroxide (LDH). Our results demonstrate that Ni(II) ions are retained via different mechanisms depending on solution conditions. At low pH, Ni retention is controlled mainly by the outer-sphere surface complexation. With increasing pH, outer-sphere and inner-sphere surface complexation dominate Ni uptake. Furthermore, Ni surface loading increases with temperature increasing at pH 6.5 due to the formation of inner-sphere surface complexes and Ni-Al LDH. The formation of Ni-Al LDH becomes the dominate mechanism at the elevated pH and temperature. In the presence of humic substances, the sorption of Ni(II) on Na-rectorite is dominated by the formation of ternary surface complexes. These results are important to understand the physicochemical behavior of Ni(II) in the natural environment. PMID:23500786

  12. Optical studies of interstellar material in low density regions of the Galaxy. I - A survey of interstellar Na I and Ca II absorption toward 57 distant stars

    NASA Technical Reports Server (NTRS)

    Sembach, K. R.; Danks, A. C.; Savage, B. D.

    1993-01-01

    We present high-resolution spectra of the Na I D and Ca II K lines toward 57 late-O and early-B stars along extended (d greater than 1 kpc) low-density paths through the Milky Way disk and halo. The sight lines preferentially sample diffuse gas in the interstellar medium (ISM) along interarm, Galactic center, and high latitude directions. We measure equivalent widths, apparent column densities, and absorption component structure. The Ca II to Na I ratios presented as a function of velocity for each sight line exhibit variations due to elemental depletion, ionization, and density enhancements. Absorption along high latitude sight lines is kinematically simpler than it is along interarm and Galactic center sight lines. Galactic rotation noticeably broadens the absorption profiles of distant stars located in these latter directions. Along several sight lines, we see Ca II absorption at velocities corresponding to large distances (/z/ about 1 kpc) from the Galactic plane. The effects of differences in the Ca II and Na I scale heights and nonzero velocity dispersions are readily apparent in the data. Brief notes are given for several sight lines with interesting absorption properties.

  13. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines

    PubMed Central

    Li, Xiao C; Shull, Gary E; Miguel-Qin, Elisa; Chen, Fang; Zhuo, Jia L

    2015-01-01

    The role of Na+/H+ exchanger 3 (NHE3) in the kidney in angiotensin II (ANG II)-induced hypertension remains unknown. The present study used global NHE3-deficient mice with transgenic rescue of the Nhe3 gene in small intestines (tgNhe3−/−) to test the hypothesis that genetic deletion of NHE3 selectively in the kidney attenuates ANG II-induced hypertension. Six groups of wild-type (tgNhe3+/+) and tgNhe3−/− mice were infused with either vehicle or ANG II (1.5 mg/kg/day, i.p., 2 weeks, or 10 nmol/min, i.v., 30 min), treated with or without losartan (20 mg/kg/day, p.o.) for 2 weeks. Basal systolic blood pressure (SBP) and mean intra-arterial blood pressure (MAP) were significantly lower in tgNhe3−/− mice (P < 0.01). Basal glomerular filtration rate, 24 h urine excretion, urinary Na+ excretion, urinary K+ excretion, and urinary Cl− excretion were significantly lower in tgNhe3−/− mice (P < 0.01). These responses were associated with significantly elevated plasma ANG II and aldosterone levels, and marked upregulation in aquaporin 1, the Na+/HCO3 cotransporter, the α1 subunit isoform of Na+/K+-ATPase, protein kinase Cα, MAP kinases ERK1/2, and glycogen synthase kinase 3 α/β in the renal cortex of tgNhe3−/− mice (P < 0.01). ANG II infusion markedly increased SBP and MAP and renal cortical transporter and signaling proteins in tgNhe3+/+, as expected, but all of these responses to ANG II were attenuated in tgNhe3−/− mice (P < 0.01). These results suggest that NHE3 in the kidney is necessary for maintaining normal blood pressure and fully developing ANG II-dependent hypertension. PMID:26564064

  14. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines.

    PubMed

    Li, Xiao C; Shull, Gary E; Miguel-Qin, Elisa; Chen, Fang; Zhuo, Jia L

    2015-11-01

    The role of Na(+/)H(+) exchanger 3 (NHE3) in the kidney in angiotensin II (ANG II)-induced hypertension remains unknown. The present study used global NHE3-deficient mice with transgenic rescue of the Nhe3 gene in small intestines (tgNhe3(-/-)) to test the hypothesis that genetic deletion of NHE3 selectively in the kidney attenuates ANG II-induced hypertension. Six groups of wild-type (tgNhe3(+/+)) and tgNhe3(-/-) mice were infused with either vehicle or ANG II (1.5 mg/kg/day, i.p., 2 weeks, or 10 nmol/min, i.v., 30 min), treated with or without losartan (20 mg/kg/day, p.o.) for 2 weeks. Basal systolic blood pressure (SBP) and mean intra-arterial blood pressure (MAP) were significantly lower in tgNhe3(-/-) mice (P < 0.01). Basal glomerular filtration rate, 24 h urine excretion, urinary Na(+) excretion, urinary K(+) excretion, and urinary Cl(-) excretion were significantly lower in tgNhe3(-/-) mice (P < 0.01). These responses were associated with significantly elevated plasma ANG II and aldosterone levels, and marked upregulation in aquaporin 1, the Na(+)/HCO3 cotransporter, the α1 subunit isoform of Na(+)/K(+)-ATPase, protein kinase Cα, MAP kinases ERK1/2, and glycogen synthase kinase 3 α/β in the renal cortex of tgNhe3(-/-) mice (P < 0.01). ANG II infusion markedly increased SBP and MAP and renal cortical transporter and signaling proteins in tgNhe3(+/+), as expected, but all of these responses to ANG II were attenuated in tgNhe3(-/-) mice (P < 0.01). These results suggest that NHE3 in the kidney is necessary for maintaining normal blood pressure and fully developing ANG II-dependent hypertension.

  15. Metabolic Programming during Lactation Stimulates Renal Na+ Transport in the Adult Offspring Due to an Early Impact on Local Angiotensin II Pathways

    PubMed Central

    Luzardo, Ricardo; Silva, Paulo A.; Einicker-Lamas, Marcelo; Ortiz-Costa, Susana; da Graça Tavares do Carmo, Maria; Vieira-Filho, Leucio D.; Paixão, Ana D. O.; Lara, Lucienne S.; Vieyra, Adalberto

    2011-01-01

    Background Several studies have correlated perinatal malnutrition with diseases in adulthood, giving support to the programming hypothesis. In this study, the effects of maternal undernutrition during lactation on renal Na+-transporters and on the local angiotensin II (Ang II) signaling cascade in rats were investigated. Methodology/Principal Findings Female rats received a hypoproteic diet (8% protein) throughout lactation. Control and programmed offspring consumed a diet containing 20% protein after weaning. Programming caused a decrease in the number of nephrons (35%), in the area of the Bowman's capsule (30%) and the capillary tuft (30%), and increased collagen deposition in the cortex and medulla (by 175% and 700%, respectively). In programmed rats the expression of (Na++K+)ATPase in proximal tubules increased by 40%, but its activity was doubled owing to a threefold increase in affinity for K+. Programming doubled the ouabain-insensitive Na+-ATPase activity with loss of its physiological response to Ang II, increased the expression of AT1 and decreased the expression of AT2 receptors), and caused a pronounced inhibition (90%) of protein kinase C activity with decrease in the expression of the α (24%) and ε (13%) isoforms. Activity and expression of cyclic AMP-dependent protein kinase decreased in the same proportion as the AT2 receptors (30%). In vivo studies at 60 days revealed an increased glomerular filtration rate (GFR) (70%), increased Na+ excretion (80%) and intense proteinuria (increase of 400% in protein excretion). Programmed rats, which had normal arterial pressure at 60 days, became hypertensive by 150 days. Conclusions/Significance Maternal protein restriction during lactation results in alterations in GFR, renal Na+ handling and in components of the Ang II-linked regulatory pathway of renal Na+ reabsorption. At the molecular level, they provide a framework for understanding how metabolic programming of renal mechanisms contributes to the onset

  16. Ovarian Cancer Stage II

    MedlinePlus

    ... hyphen, e.g. -historical Searches are case-insensitive Ovarian Cancer Stage II Add to My Pictures View /Download : ... 1650x675 View Download Large: 3300x1350 View Download Title: Ovarian Cancer Stage II Description: Three-panel drawing of stage ...

  17. World War II Homefront.

    ERIC Educational Resources Information Center

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  18. Multiple endocrine neoplasia (MEN) II

    MedlinePlus

    Sipple syndrome; MEN II; Pheochromocytoma - MEN II; Thyroid cancer - pheochromocytoma; Parathyroid cancer - pheochromocytoma ... The cause of MEN II is a defect in a gene called RET. This defect causes many tumors to appear in the same ...

  19. PROBING OUR HELIOSPHERIC HISTORY. I. HIGH-RESOLUTION OBSERVATIONS OF Na I AND Ca II ALONG THE SOLAR HISTORICAL TRAJECTORY

    SciTech Connect

    Wyman, Katherine; Redfield, Seth E-mail: sredfield@wesleyan.edu

    2013-08-20

    Over the course of its motion through the Galaxy, our solar system has encountered many interstellar environments of varying characteristics. Interstellar medium (ISM) density variations spanning seven orders of magnitude are commonly seen throughout the general Galactic environment, and a sufficiently dense cloud within this range has the potential to dramatically alter the structure of the heliosphere. We present observations of the ISM environments the Sun has most recently encountered based on high-resolution optical spectra toward nearby stars in the direction of the historical solar trajectory. The data were obtained with the highest-resolution spectrographs available, including the Tull Spectrograph on the Harlan J. Smith Telescope at McDonald Observatory and the Ultra-High-Resolution Facility on the Anglo-Australian Telescope at the Anglo-Australian Observatory. Observations were made of interstellar Na I and Ca II doublet absorption toward 43 bright stars within {approx}500 pc. No absorption is seen out to a distance of 120 pc (consistent with the outer boundary of the Local Bubble), but a complex collection of absorbers is seen in stars beyond 120 pc. While common absorbers are consistently seen in most sight lines, significant spatial variation is also detected, even between closely spaced sight lines. This pervasive evidence of small-scale structure not only speaks to the complexity of the morphology or physical properties of the gas in the ISM, but also emphasizes that dramatic structural changes to the heliosphere are common and it is important to understand the implications of such changes, such as the modulation in the cosmic ray flux, on planets.

  20. Network II Database

    1994-11-07

    The Oak Ridge National Laboratory (ORNL) Rail and Barge Network II Database is a representation of the rail and barge system of the United States. The network is derived from the Federal Rail Administration (FRA) rail database.

  1. Factor II deficiency

    MedlinePlus

    ... blood. It leads to problems with blood clotting (coagulation). Factor II is also known as prothrombin. ... blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or ...

  2. Free energy of formation for green rust sodium sulphate (NaFe II6Fe III3(OH) 18(SO 4) 2(s))

    NASA Astrophysics Data System (ADS)

    Davesne, E.; Dideriksen, K.; Christiansen, B. C.; Sonne, M.; Ayala-Luis, K. B.; Koch, C. Bender; Hansen, H. C. B.; Stipp, S. L. S.

    2010-11-01

    In a recent study, sulphate-bearing green rust (GR) was shown to incorporate Na + in its structure (NaFe II6Fe III3(OH) 18(SO 4) 2(s); GR). The compound was synthesised by aerial oxidation of Fe(OH) 2(s) in the presence of NaOH. This paper reports on its free energy of formation (ΔGf0). Freshly synthesised GR was titrated with 0.5 M H 2SO 4 in an inert atmosphere at 25 °C, producing dissolved Fe 2+ and magnetite or goethite. Solution concentrations, PHREEQC and the MINTEQ database were used to calculate reaction constants for the reactions: 2NaFeII6 FeIII3 (OH)18(SO)+12H+(aq) ⇆9Fe2+(aq) +2Na+(aq) +4SO42-(aq) +3FeFeIII2 O+24HO,K=10 and NaFeII6 FeIII3 (OH)18(SO)+9H(aq)+⇆6Fe2+(aq) +Na+(aq) +2SO42-(aq) +3α-FeOOH+12HO,K=10. From the determined equilibrium constants and published ΔGf0 values for the other compounds, we derived ΔGf0 = -6366 ± 18 kJ/mol for anhydrous GR. The solubility product at 25 °C and atmospheric pressure is K = 10 -210.5±3.2. It is not yet known if the extent of Na + incorporation in GR depends on formation pathway; it cannot be excluded that both Na-free GR and GR exist. If so, uncertainty in ΔGf0 determined from acid titration is such that the EH-pH stability fields of the two phases are statistically indistinguishable for Na + concentrations as low as ˜30 μM (2 SD level; 0.036 M SO 42- concentration). In sea water, where Na + and SO 42- concentrations are high, but soluble Fe 2+ is low, GR is expected to form where local conditions increase concentration gradients, such as for corrosion of metallic iron and steel. Another example of an environment that would provide GR-favourable conditions is a degrading concrete and steel radioactive waste storage facility, where groundwater is saline. Green rust is a well-known sink for redox-active trace components, making it a compound that should be considered in risk assessment modelling of groundwater quality. Phase stability is critical in such simulations.

  3. Carnitine palmitoyltransferase II deficiency

    PubMed Central

    Roe, C R.; Yang, B-Z; Brunengraber, H; Roe, D S.; Wallace, M; Garritson, B K.

    2008-01-01

    Background: Carnitine palmitoyltransferase II (CPT II) deficiency is an important cause of recurrent rhabdomyolysis in children and adults. Current treatment includes dietary fat restriction, with increased carbohydrate intake and exercise restriction to avoid muscle pain and rhabdomyolysis. Methods: CPT II enzyme assay, DNA mutation analysis, quantitative analysis of acylcarnitines in blood and cultured fibroblasts, urinary organic acids, the standardized 36-item Short-Form Health Status survey (SF-36) version 2, and bioelectric impedance for body fat composition. Diet treatment with triheptanoin at 30% to 35% of total daily caloric intake was used for all patients. Results: Seven patients with CPT II deficiency were studied from 7 to 61 months on the triheptanoin (anaplerotic) diet. Five had previous episodes of rhabdomyolysis requiring hospitalizations and muscle pain on exertion prior to the diet (two younger patients had not had rhabdomyolysis). While on the diet, only two patients experienced mild muscle pain with exercise. During short periods of noncompliance, two patients experienced rhabdomyolysis with exercise. None experienced rhabdomyolysis or hospitalizations while on the diet. All patients returned to normal physical activities including strenuous sports. Exercise restriction was eliminated. Previously abnormal SF-36 physical composite scores returned to normal levels that persisted for the duration of the therapy in all five symptomatic patients. Conclusions: The triheptanoin diet seems to be an effective therapy for adult-onset carnitine palmitoyltransferase II deficiency. GLOSSARY ALT = alanine aminotransferase; AST = aspartate aminotransferase; ATP = adenosine triphosphate; BHP = β-hydroxypentanoate; BKP = β-ketopentanoate; BKP-CoA = β-ketopentanoyl–coenzyme A; BUN = blood urea nitrogen; CAC = citric acid cycle; CoA = coenzyme A; CPK = creatine phosphokinase; CPT II = carnitine palmitoyltransferase II; LDL = low-density lipoprotein; MCT

  4. PEP-II Status

    SciTech Connect

    Sullivan, M.; Bertsche, K.; Browne, M.; Cai, Y.; Cheng, W.; Colocho, W.; Decker, F.-J.; Donald, M.; Ecklund, S.; Erickson, R.; Fisher, A.S.; Fox, J.; Heifets, S.; Himel, T.; Iverson, R.; Kulikov, A.; Novokhatski, A.; Pacak, V.; Pivi, M.; Rivetta, C.; Ross, M.; /SLAC /Saclay /Frascati

    2008-07-25

    PEP-II and BaBar have just finished run 7, the last run of the SLAC B-factory. PEP-II was one of the few high-current e+e- colliding accelerators and holds the present world record for stored electrons and stored positrons. It has stored 2.07 A of electrons, nearly 3 times the design current of 0.75 A and it has stored 3.21 A of positrons, 1.5 times more than the design current of 2.14 A. High-current beams require careful design of several systems. The feedback systems that control instabilities, the RF system stability loops, and especially the vacuum systems have to handle the higher power demands. We present here some of the accomplishments of the PEP-II accelerator and some of the problems we encountered while running high-current beams.

  5. About APPLE II Operation

    SciTech Connect

    Schmidt, T.; Zimoch, D.

    2007-01-19

    The operation of an APPLE II based undulator beamline with all its polarization states (linear horizontal and vertical, circular and elliptical, and continous variation of the linear vector) requires an effective description allowing an automated calculation of gap and shift parameter as function of energy and operation mode. The extension of the linear polarization range from 0 to 180 deg. requires 4 shiftable magnet arrrays, permitting use of the APU (adjustable phase undulator) concept. Studies for a pure fixed gap APPLE II for the SLS revealed surprising symmetries between circular and linear polarization modes allowing for simplified operation. A semi-analytical model covering all types of APPLE II and its implementation will be presented.

  6. About APPLE II Operation

    NASA Astrophysics Data System (ADS)

    Schmidt, T.; Zimoch, D.

    2007-01-01

    The operation of an APPLE II based undulator beamline with all its polarization states (linear horizontal and vertical, circular and elliptical, and continous variation of the linear vector) requires an effective description allowing an automated calculation of gap and shift parameter as function of energy and operation mode. The extension of the linear polarization range from 0 to 180° requires 4 shiftable magnet arrrays, permitting use of the APU (adjustable phase undulator) concept. Studies for a pure fixed gap APPLE II for the SLS revealed surprising symmetries between circular and linear polarization modes allowing for simplified operation. A semi-analytical model covering all types of APPLE II and its implementation will be presented.

  7. Mod II engine performance

    NASA Technical Reports Server (NTRS)

    Richey, Albert E.; Huang, Shyan-Cherng

    1987-01-01

    The testing of a prototype of an automotive Stirling engine, the Mod II, is discussed. The Mod II is a one-piece cast block with a V-4 single-crankshaft configuration and an annular regenerator/cooler design. The initial testing of Mod II concentrated on the basic engine, with auxiliaries driven by power sources external to the engine. The performance of the engine was tested at 720 C set temperature and 820 C tube temperature. At 720 C, it is observed that the power deficiency is speed dependent and linear, with a weak pressure dependency, and at 820 C, the power deficiency is speed and pressure dependent. The effects of buoyancy and nozzle spray pattern on the heater temperature spread are investigated. The characterization of the oil pump and the operating cycle and temperature spread tests are proposed for further evaluation of the engine.

  8. The Eutelsat II programme

    NASA Astrophysics Data System (ADS)

    Burgio, Claude; Dumesnil, Jean-Jacques

    Eutelsat II is designed to provide Europe with Ku-band communication and TV services with 16 active channels of 50 W power output. In-orbit reconfigurable antenna feed networks permit customized transmission offering either medium-gain over the whole of Europe or high-gain over tailored geographic areas, allowing TV reception on dishes as small as 60 cm. The payload design makes use of only two antennas, each comprising a dual dish reflector and two reconfigurable primary feed arrays. This paper gives an overview of the Eutelsat II mission, and presents a technical description of the satellite, the program schedule, and future prospects.

  9. SAGE II Ozone Analysis

    NASA Technical Reports Server (NTRS)

    Cunnold, Derek; Wang, Ray

    2002-01-01

    Publications from 1999-2002 describing research funded by the SAGE II contract to Dr. Cunnold and Dr. Wang are listed below. Our most recent accomplishments include a detailed analysis of the quality of SAGE II, v6.1, ozone measurements below 20 km altitude (Wang et al., 2002 and Kar et al., 2002) and an analysis of the consistency between SAGE upper stratospheric ozone trends and model predictions with emphasis on hemispheric asymmetry (Li et al., 2001). Abstracts of the 11 papers are attached.

  10. [Study on hemolytic mechanism of polyphyllin II].

    PubMed

    Ning, Li-hua; Zhou, Bo; Zhang, Yao-xiang; Li, Xin-ping

    2015-09-01

    To study the hemolytic effect of polyphyllin II (PP II) mediated by anion channel protein and glucose transporter 1 (GLUT1), in order to initially reveal its hemolytic mechanism in vitro. In the experiment, the spectrophotometric method was adopted to detect the hemolysis of PP II in vitro and the effect of anion channel-related solution and blocker, glucose channel-related inhibitor and multi-target drugs dehydroepiandrosterone (DHEA) and diazepam on the hemolysis of PP II. The scanning electron microscope and transmission electron microscope were used to observe the effect of PP II on erythrocyte (RBC) morphology. The results showed that PP II -processed blood cells were severely deformed into spherocytes, acanthocyturia and vesicae. According to the results of the PP II hemolysis experiment in vitro, the anion hypertonic solution LiCl, NaHCO3, Na2SO4 and PBS significantly inhibited the hemolysis induced by PP II (P < 0.05), while blockers NPPB and DIDS remarkably promoted it (P < 0.01). Hyperosmotic sodium chloride, fructose and glucose at specific concentrations notably antagonized the hemolysis induced by PP II (P < 0.05). The glucose channel inhibitor Cytochalasin B and verapamil remarkably antagonized the hemolysis induced by PP II (P < 0.01). The hemolysis induced by PP II could also be antagonized by 1 gmol x L(1) diazepam and 100 μmol x L(-1) DHEA pretreated for 1 min (P < 0.01). In conclusion, the hemolytic mechanism of PP II in vitro may be related to the increase in intracellular osmotic pressure and rupture of erythrocytes by changing the anion channel transport activity, with GLUT1 as the major competitive interaction site. PMID:26983211

  11. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

    PubMed

    Henriques, Sónia Troeira; Deplazes, Evelyne; Lawrence, Nicole; Cheneval, Olivier; Chaousis, Stephanie; Inserra, Marco; Thongyoo, Panumart; King, Glenn F; Mark, Alan E; Vetter, Irina; Craik, David J; Schroeder, Christina I

    2016-08-12

    ProTx-II is a disulfide-rich peptide toxin from tarantula venom able to inhibit the human voltage-gated sodium channel 1.7 (hNaV1.7), a channel reported to be involved in nociception, and thus it might have potential as a pain therapeutic. ProTx-II acts by binding to the membrane-embedded voltage sensor domain of hNaV1.7, but the precise peptide channel-binding site and the importance of membrane binding on the inhibitory activity of ProTx-II remain unknown. In this study, we examined the structure and membrane-binding properties of ProTx-II and several analogues using NMR spectroscopy, surface plasmon resonance, fluorescence spectroscopy, and molecular dynamics simulations. Our results show a direct correlation between ProTx-II membrane binding affinity and its potency as an hNaV1.7 channel inhibitor. The data support a model whereby a hydrophobic patch on the ProTx-II surface anchors the molecule at the cell surface in a position that optimizes interaction of the peptide with the binding site on the voltage sensor domain. This is the first study to demonstrate that binding of ProTx-II to the lipid membrane is directly linked to its potency as an hNaV1.7 channel inhibitor. PMID:27311819

  12. An unprecedented one-step synthesis of octahedral Cu(ii)-bis(iminoquinone) complexes and their reactivity with NaBH4.

    PubMed

    Mondal, Manas Kumar; Mukherjee, Chandan

    2016-09-14

    A new non-innocent ligand, H2L(AP(o-NO2-OPh)), was synthesized. The ligand H2L(AP(o-NO2-OPh)) reacted with 0.5 equivalents of CuCl2·2H2O and provided the corresponding mononuclear four-coordinate [Cu(ii)-bis(iminosemiquinone)] complex (1). Interestingly, the ligand upon reacting with 2 equivalents of CuCl2·2H2O in the presence of Et3N and air provided the corresponding trans-dichloride-bound six-coordinate mononuclear Cu(ii)-complex (2) in one step. To extend the validity of the newly developed one-step synthesis of the trans-dichloride-bound Cu(ii)-bis(iminoquinone) complex using a non-innocent ligand and 2 equivalents of CuCl2·2H2O, the previously reported non-innocent ligand H2L(AP) was further examined. Thus the formed trans-dichloride-bound Cu(ii)-bis(iminoquinone) complex was designated as complex 3. The complexes were characterized by IR, mass, UV-Vis/NIR, X-band EPR, and X-ray single crystal diffraction techniques. Molecular structure analysis confirmed that in 1 the oxidation state of the coordinating ligands was [L(ISQ(o-NO2-OPh))](1-), i.e., one-electron oxidized iminosemiquinone. In 2 and 3·CH2Cl2, both the coordinated-ligands were present in their two-electron oxidized iminoquinone form. The iminoquinone-complex formation was found to proceed with the generation of CuCl salt. X-band EPR spectrum measurement confirmed that both the iminoquinone-complexes were paramagnetic and the unpaired electron was located at the 3dx(2)-y(2) orbital of Cu(ii) ions. When the Cu(ii)-bis(iminoquinone) complex 3 was subjected to react with NaBH4 in dry CH3CN, H2 gas was formed along with the generation of the corresponding Cu(ii)-bis(iminosemiquinone) complex. GC analyses were performed for the identification of H2 gas. PMID:27506307

  13. College Algebra II.

    ERIC Educational Resources Information Center

    Benjamin, Carl; And Others

    Presented are student performance objectives, a student progress chart, and assignment sheets with objective and diagnostic measures for the stated performance objectives in College Algebra II. Topics covered include: differencing and complements; real numbers; factoring; fractions; linear equations; exponents and radicals; complex numbers,…

  14. Listen & Learn II.

    ERIC Educational Resources Information Center

    Community Building Resources, Spruce Grove (Alberta).

    Six community builders in Edmonton, Alberta, planned, developed, and implemented Listen and Learn II, a reflective research project in asset-based community building, over a 6-month period in 1998. They met regularly over 2 months to plan the research and design a method that was open to participation at any stage, encouraged exchange of…

  15. Instant Insanity II

    ERIC Educational Resources Information Center

    Richmond, Tom; Young, Aaron

    2013-01-01

    "Instant Insanity II" is a sliding mechanical puzzle whose solution requires the special alignment of 16 colored tiles. We count the number of solutions of the puzzle's classic challenge and show that the more difficult ultimate challenge has, up to row permutation, exactly two solutions, and further show that no…

  16. Dissecting Diversity Part II

    ERIC Educational Resources Information Center

    Matthews, Frank

    2005-01-01

    This article presents "Dissecting Diversity, Part II," the conclusion of a wide-ranging two-part roundtable discussion on diversity in higher education. The participants were as follows: Lezli Baskerville, J.D., President and CEO of the National Association for Equal Opportunity (NAFEO); Dr. Gerald E. Gipp, Executive Director of the American…

  17. Periodontics II: Course Proposal.

    ERIC Educational Resources Information Center

    Dordick, Bruce

    A proposal is presented for Periodontics II, a course offered at the Community College of Philadelphia to give the dental hygiene/assisting student an understanding of the disease states of the periodontium and their treatment. A standardized course proposal cover form is given, followed by a statement of purpose for the course, a list of major…

  18. An ultraviolet melting study of the stability of the DNA double helix in the NaDNA-bipyridyl-(ethylenediamine)platintum(II) complex.

    PubMed

    Szabó, S; Lee, S A

    2008-08-01

    Complexes of NaDNA with the bipyridyl-(ethylenediamine)platintum(II) (abbreviated [(bipy)Pt(en)]2+) molecular ion have been studied in solution via ultraviolet absorption experiments at 260 nm between 50 and 90 degrees C. These measurements, performed as a function of the molar ratio of the [(bipy)Pt(en)]2+ complex to DNA base pairs, show that the stability of the DNA double helix is increased by the formation of the DNA.[(bipy)Pt(en)]2+ complex: at a molar ratio of 0.33, the temperature at which the DNA double helix separates into two single strands is increased by about 15 degrees C.

  19. Role of Bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-Responsive Repressor

    SciTech Connect

    Kandegedara, A.; Thiyagarajan, S; Kondapalli, K; Stemmler, T; Rosen, B

    2009-01-01

    The Staphylococcus aureus plasmid pI258 cadCA operon encodes a P-type ATPase, CadA, that confers resistance to Cd(II)/Pb(II)/Zn(II). Expression is regulated by CadC, a homodimeric repressor that dissociates from the cad operator/promoter upon binding of Cd(II), Pb(II), or Zn(II). CadC is a member of the ArsR/SmtB family of metalloregulatory proteins. The crystal structure of CadC shows two types of metal binding sites, termed Site 1 and Site 2, and the homodimer has two of each. Site 1 is the physiological inducer binding site. The two Site 2 metal binding sites are formed at the dimerization interface. Site 2 is not regulatory in CadC but is regulatory in the homologue SmtB. Here the role of each site was investigated by mutagenesis. Both sites bind either Cd(II) or Zn(II). However, Site 1 has higher affinity for Cd(II) over Zn(II), and Site 2 prefers Zn(II) over Cd(II). Site 2 is not required for either derepression or dimerization. The crystal structure of the wild type with bound Zn(II) and of a mutant lacking Site 2 was compared with the SmtB structure with and without bound Zn(II). We propose that an arginine residue allows for Zn(II) regulation in SmtB and, conversely, a glycine results in a lack of regulation by Zn(II) in CadC. We propose that a glycine residue was ancestral whether the repressor binds Zn(II) at a Site 2 like CadC or has no Site 2 like the paralogous ArsR and implies that acquisition of regulatory ability in SmtB was a more recent evolutionary event.

  20. Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCA/NaCl-Induced Hypertension in Female Rats.

    PubMed

    Dai, Shu-Yan; Zhang, Yu-Ping; Peng, Wei; Shen, Ying; He, Jing-Jing

    2016-01-01

    The present study investigated whether central activation of angiotensin II type 2 receptor (AT2-R) attenuates deoxycorticosterone acetate (DOCA)/NaCl-induced hypertension in intact and ovariectomized (OVX) female rats and whether female sex hormone status has influence on the effects of AT2-R activation. DOCA/NaCl elicited a greater increase in blood pressure in OVX females than that in intact females. Central infusion of compound 21, a specific AT2-R agonist, abolished DOCA/NaCl pressor effect in intact females, whereas same treatment in OVX females produced an inhibitory effect. Real-time RT-PCR analysis revealed that DOCA/NaCl enhanced the mRNA expression of hypertensive components including AT1-R, ACE-1, and TNF-α in the paraventricular nucleus of hypothalamus in both intact and OVX females. However, the mRNA expressions of antihypertensive components such as AT2-R, ACE-2, and IL-10 were increased only in intact females. Central AT2-R agonist reversed the changes in the hypertensive components in all females, while this agonist further upregulated the expression of ACE2 and IL-10 in intact females, but only IL-10 in OVX females. These results indicate that brain AT2-R activation plays an inhibitory role in the development of DOCA/NaCl-induced hypertension in females. This beneficial effect of AT2-R activation involves regulation of renin-angiotensin system and proinflammatory cytokines.

  1. Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCA/NaCl-Induced Hypertension in Female Rats

    PubMed Central

    Dai, Shu-Yan; Zhang, Yu-Ping; Peng, Wei; Shen, Ying; He, Jing-Jing

    2016-01-01

    The present study investigated whether central activation of angiotensin II type 2 receptor (AT2-R) attenuates deoxycorticosterone acetate (DOCA)/NaCl-induced hypertension in intact and ovariectomized (OVX) female rats and whether female sex hormone status has influence on the effects of AT2-R activation. DOCA/NaCl elicited a greater increase in blood pressure in OVX females than that in intact females. Central infusion of compound 21, a specific AT2-R agonist, abolished DOCA/NaCl pressor effect in intact females, whereas same treatment in OVX females produced an inhibitory effect. Real-time RT-PCR analysis revealed that DOCA/NaCl enhanced the mRNA expression of hypertensive components including AT1-R, ACE-1, and TNF-α in the paraventricular nucleus of hypothalamus in both intact and OVX females. However, the mRNA expressions of antihypertensive components such as AT2-R, ACE-2, and IL-10 were increased only in intact females. Central AT2-R agonist reversed the changes in the hypertensive components in all females, while this agonist further upregulated the expression of ACE2 and IL-10 in intact females, but only IL-10 in OVX females. These results indicate that brain AT2-R activation plays an inhibitory role in the development of DOCA/NaCl-induced hypertension in females. This beneficial effect of AT2-R activation involves regulation of renin-angiotensin system and proinflammatory cytokines. PMID:26783414

  2. Introducing CAML II

    SciTech Connect

    Pelaia II, Tom; Boyes, Matthew

    2009-01-01

    Channel Access Markup Language (CAML) is a XML based markup language and implementation for displaying EPICS channel access controls within a web browser. The CAML II project expanded upon the work of CAML I adding more features and greater integration with other web technologies. The most dramatic new feature introduced in CAML II is the introduction of a namespace so CAML controls can be embedded within XHTML documents. A repetition template with macro substitution allows for rapid coding of arbitrary XHTML repetitions. Enhancements have been made to several controls including more powerful plotting options. Advanced formatting options were introduced for text controls. Virtual process variables allow for custom calculations. An EDL to CAML translator eases the transition from EDM screens to CAML pages.

  3. RADTRAN II user guide

    SciTech Connect

    Madsen, M M; Wilmot, E L; Taylor, J M

    1983-02-01

    RADTRAN II is a flexible analytical tool for calculating both the incident-free and accident impacts of transporting radioactive materials. The consequences from incident-free shipments are apportioned among eight population subgroups and can be calculated for several transport modes. The radiological accident risk (probability times consequence summed over all postulated accidents) is calculated in terms of early fatalities, early morbidities, latent cancer fatalities, genetic effects, and economic impacts. Groundshine, inhalation, direct exposure, resuspension, and cloudshine dose pathways are modeled to calculate the radiological health risks from accidents. Economic impacts are evaluated based on costs for emergency response, cleanup, evacuation, income loss, and land use. RADTRAN II can be applied to specific scenario evaluations (individual transport modes or specified combinations), to compare alternative modes or to evaluate generic radioactive material shipments. Unit-risk factors can easily be evaluated to aid in performing generic analyses when several options must be compared with the amount of travel as the only variable.

  4. Results from SAGE II

    SciTech Connect

    Nico, J.S.

    1994-10-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66{sub -13}{sup +18} (stat) {sub -7}{sup +5} (sys) SNU. Combined with the SAGE I result of 73{sub -16}{sup +18} (stat) {sub -7}{sup 5} (sys) SNU, the capture rate is 69{sub -11}{sup +11} (stat) {sub -7}{sup +5} (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models.

  5. TARN II project

    SciTech Connect

    Katayama, T.

    1985-04-01

    On the basis of the achievement of the accelerator studies at present TARN, it is decided to construct the new ring TARN II which will be operated as an accumulator, accelerator, cooler and stretcher. It has the maximum magnetic rigidity of 7 Txm corresponding to the proton energy 1.3 GeV and the ring diameter is around 23 m. Light and heavy ions from the SF cyclotron will be injected and accelerated to the working energy where the ring will be operated as a desired mode, for example a cooler ring mode. At the cooler ring operation, the strong cooling devices such as stochastic and electron beam coolings will work together with the internal gas jet target for the precise nuclear experiments. TARN II is currently under the contruction with the schedule of completion in 1986. In this paper general features of the project are presented.

  6. Ribosomal Database Project II

    DOE Data Explorer

    The Ribosomal Database Project (RDP) provides ribosome related data and services to the scientific community, including online data analysis and aligned and annotated Bacterial small-subunit 16S rRNA sequences. As of March 2008, RDP Release 10 is available and currently (August 2009) contains 1,074,075 aligned 16S rRNA sequences. Data that can be downloaded include zipped GenBank and FASTA alignment files, a histogram (in Excel) of the number of RDP sequences spanning each base position, data in the Functional Gene Pipeline Repository, and various user submitted data. The RDP-II website also provides numerous analysis tools.[From the RDP-II home page at http://rdp.cme.msu.edu/index.jsp

  7. RISTA II trials

    NASA Astrophysics Data System (ADS)

    Martin, John R.

    1998-11-01

    Northrop Grumman Corporation has developed an advanced 2nd generation IR sensor system under the guidance of the US Army's Night Vision and Electronic Sensors Directorate (NVESD) as part of an Advanced Concept Technology Demonstration (ACTD) called Counter Mobile Rocket Launcher (CMRL). Designed to support rapid counter fire against mobile targets from an unmanned aerial vehicle (UAV), the sensor system, called reconnaissance IR surveillance target acquisition (RISTA II), consists of a 2nd generation FLIR/line scanner, a digital data link, a ground processing facility, and an aided target recognizer (AiTF). The concept of operation together with component details was reported at the passive sensors IRIS in March, 1996. The performance testing of the RISTA II System was reported at the National IRIS in November, 1997. The RISTA II sensor has subsequently undergone performance testing on a Royal Netherlands Air Force F-16 for a manned reconnaissance application in August and October, 1997, at Volkel Airbase, Netherlands. That testing showed performance compatible with the medium altitude IR sensor performance. The results of that testing, together with flight test imagery, will be presented.

  8. Successful closure of treatment-naïve, flat edge (Type II), full-thickness macular hole using inverted internal limiting membrane flap technique

    PubMed Central

    Hussain, Nazimul; Hussain, Anjli

    2016-01-01

    Objective The objective of this study was to present the outcome of the internal limiting membrane (ILM) peeling flap technique for a treatment-naïve, flat edge (Type II), full-thickness macular hole (MH). Methods A 52-year-old man presented with complaints of decreased vision and seeing black spot. He was diagnosed to have a flat edge, full-thickness MH, which was confirmed by optical coherence tomography (OCT). He underwent 23G vitrectomy with brilliant blue G-assisted inverted ILM peeling with an inverted flap over the hole followed by fluid gas exchange. Results Postoperative follow-up until 3 months showed successful closure of the MH, which was confirmed by OCT. The best-corrected visual acuity improved from baseline 6/60 to 6/12 at the final follow-up. Conclusion Using the inverted ILM flap technique, a treatment-naïve, flat edge (Type II), full thickness MH achieved successful anatomical and functional outcomes. PMID:27785110

  9. Achieving enhanced visible-light-driven photocatalysis using type-II NaNbO3/CdS core/shell heterostructures.

    PubMed

    Kumar, Sandeep; Khanchandani, Sunita; Thirumal, Meganathan; Ganguli, Ashok K

    2014-08-13

    Expanding the light-harvesting range and suppressing the quick recombination of photogenerated charge carriers are of paramount significance in the field of photocatalysis. One possible approach to achieve wide absorption range is to synthesize type-II core/shell heterostructures. In addition, this system also shows great promise for fast separation of charge carriers and low charge recombination rate. Herein, following the surface functionalization method using 3-mercaptopropionic acid (MPA) as a surface functionalizing agent, we report on designing NaNbO3/CdS type-II core/shell heterostructures with an absorption range extending to visible range and explore the opportunity toward degradation of methylene blue (MB) dye as a model pollutant under visible light irradiation. Characterizations including X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), UV-vis diffuse reflectance spectrum (DRS), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), and Raman spectroscopy support the growth of CdS shell onto NaNbO3 nanorods. The resulting core/shell heterostructures unveiled high surface areas, enhanced light harvesting, and appreciably increased photocatalytic activity toward MB degradation compared to individual counterparts and the photocatalytic standard, Degussa P25, under visible light irradiation. The remarkably enhanced photocatalytic activity of core/shell heterostructures could be interpreted in terms of efficient charge separation owing to core/shell morphology and resulting type-II band alignment between NaNbO3 and CdS, which creates a step-like radial potential favoring the localization of one of the carriers in the core and the other in the shell. A plausible mechanism for the degradation of MB dye over NaNbO3/CdS core/shell heterostructures is also elucidated using active species scavenger studies. Our findings imply that hydroxyl radicals (OH(•)) play a crucial role in dictating the degradation

  10. Competitive adsorption of copper(II), cadmium(II), lead(II) and zinc(II) onto basic oxygen furnace slag.

    PubMed

    Xue, Yongjie; Hou, Haobo; Zhu, Shujing

    2009-02-15

    Polluted and contaminated water can often contain more than one heavy metal species. It is possible that the behavior of a particular metal species in a solution system will be affected by the presence of other metals. In this study, we have investigated the adsorption of Cd(II), Cu(II), Pb(II), and Zn(II) onto basic oxygen furnace slag (BOF slag) in single- and multi-element solution systems as a function of pH and concentration, in a background solution of 0.01M NaNO(3). In adsorption edge experiments, the pH was varied from 2.0 to 13.0 with total metal concentration 0.84mM in the single element system and 0.21mM each of Cd(II), Cu(II), Pb(II), and Zn(II) in the multi-element system. The value of pH(50) (the pH at which 50% adsorption occurs) was found to follow the sequence Zn>Cu>Pb>Cd in single-element systems, but Pb>Cu>Zn>Cd in the multi-element system. Adsorption isotherms at pH 6.0 in the multi-element systems showed that there is competition among various metals for adsorption sites on BOF slag. The adsorption and potentiometric titrations data for various slag-metal systems were modeled using an extended constant-capacitance surface complexation model that assumed an ion-exchange process below pH 6.5 and the formation of inner-sphere surface complexes at higher pH. Inner-sphere complexation was more dominant for the Cu(II), Pb(II) and Zn(II) systems.

  11. NSLS II Vacuum System

    SciTech Connect

    Ferreira, M.; Doom, L.; Hseuh, H.; Longo, C.; Settepani, P.; Wilson, K.; Hu, J.

    2009-09-13

    National Synchrotron Light Source II, being constructed at Brookhaven, is a 3-GeV, 500 mA, 3rd generation synchrotron radiation facility with ultra low emittance electron beams. The storage ring vacuum system has a circumference of 792 m and consists of over 250 vacuum chambers with a simulated average operating pressure of less than 1 x 10{sup -9} mbar. A summary of the update design of the vacuum system including girder supports of the chambers, gauges, vacuum pumps, bellows, beam position monitors and simulation of the average pressure will be shown. A brief description of the techniques and procedures for cleaning and mounting the chambers are given.

  12. Delta II Mars Pathfinder

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Final preparations for lift off of the DELTA II Mars Pathfinder Rocket are shown. Activities include loading the liquid oxygen, completing the construction of the Rover, and placing the Rover into the Lander. After the countdown, important visual events include the launch of the Delta Rocket, burnout and separation of the three Solid Rocket Boosters, and the main engine cutoff. The cutoff of the main engine marks the beginning of the second stage engine. After the completion of the second stage, the third stage engine ignites and then cuts off. Once the third stage engine cuts off spacecraft separation occurs.

  13. Run II luminosity progress

    SciTech Connect

    Gollwitzer, K.; /Fermilab

    2007-06-01

    The Fermilab Tevatron Collider Run II program continues at the energy and luminosity frontier of high energy particle physics. To the collider experiments CDF and D0, over 3 fb{sup -1} of integrated luminosity has been delivered to each. Upgrades and improvements in the Antiproton Source of the production and collection of antiprotons have led to increased number of particles stored in the Recycler. Electron cooling and associated improvements have help make a brighter antiproton beam at collisions. Tevatron improvements to handle the increased number of particles and the beam lifetimes have resulted in an increase in luminosity.

  14. Angiotensin II and renal tubular ion transport.

    PubMed

    Valles, Patricia; Wysocki, Jan; Batlle, Daniel

    2005-08-29

    Angiotensin II, a potent vasoconstrictor, also participates in the regulation of renal sodium and water excretion, not only via a myriad of effects on renal hemodynamics, glomerular filtration rate, and regulation of aldosterone secretion, but also via direct effects on renal tubule transport. In addition, angiotensin II stimulates H+ secretion and HCO3- reabsorption in both proximal and distal tubules and regulates H+-ATPase activity in intercalated cells of the collecting tubule. Different results regarding the effect of angiotensin II on bicarbonate reabsorption and proton secretion have been reported at the functional level, depending on the angiotensin II concentration and tubule segment studied. It is likely that interstitial angiotensin II is more important in regulating hemodynamic and transport functions than circulating angiotensin II. In proximal tubules, stimulation of bicarbonate reabsorption, Na+/H+-exchange, and Na+/HCO3- cotransport has been found using low concentrations (<10(-9) M), while inhibition of bicarbonate reabsorption has been documented using concentrations higher than 10(-8) M. Evidence for the regulation of H+-ATPase activity in vivo and in vitro by trafficking/exocytosis has been provided. An additional level of H+-ATPase regulation via protein synthesis may be important as well. Recently, we have shown that both aldosterone and angiotensin II provide such a mechanism of regulation in vivo at the level of the medullary collecting tubule. Interestingly, in this part of the nephron, the effects of aldosterone and angiotensin II are not sodium dependent, whereas in the cortical collecting duct, both aldosterone and angiotensin II, by contrast, affect H+ secretion by sodium-dependent mechanisms.

  15. Evaluation of the computerized procedures Manual II (COPMA II)

    SciTech Connect

    Converse, S.A.

    1995-11-01

    The purpose of this study was to evaluate the effects of a computerized procedure system, the Computerized Procedure Manual II (COPMA-II), on the performance and mental workload of licensed reactor operators. To evaluate COPMA-II, eight teams of two operators were trained to operate a scaled pressurized water reactor facility (SPWRF) with traditional paper procedures and with COPMA-II. Following training, each team operated the SPWRF under normal operating conditions with both paper procedures and COPMA-II. The teams then performed one of two accident scenarios with paper procedures, but performed the remaining accident scenario with COPMA-II. Performance measures and subjective estimates of mental workload were recorded for each performance trial. The most important finding of the study was that the operators committed only half as many errors during the accident scenarios with COPMA-II as they committed with paper procedures. However, time to initiate a procedure was fastest for paper procedures for accident scenario trials. For performance under normal operating conditions, there was no difference in time to initiate or to complete a procedure, or in the number of errors committed with paper procedures and with COPMA-II. There were no consistent differences in the mental workload ratings operators recorded for trials with paper procedures and COPMA-II.

  16. A KEY PHYSICAL MECHANISM FOR UNDERSTANDING THE ENIGMATIC LINEAR POLARIZATION OF THE SOLAR Ba II AND Na I D{sub 1} LINES

    SciTech Connect

    Belluzzi, Luca; Trujillo Bueno, Javier

    2013-09-10

    The linearly polarized spectrum of the solar limb radiation produced by scattering processes is of great diagnostic potential for exploring the magnetism of the solar atmosphere. This spectrum shows an impressive richness of spectral details and enigmatic Q/I signals, whose physical origin must be clearly understood before they can be exploited for diagnostic purposes. The most enduring enigma is represented by the polarization signals observed in the D{sub 1} resonance lines of Na I (5896 A) and Ba II (4934 A), which were expected to be intrinsically unpolarizable. The totality of sodium and 18% of barium have hyperfine structure (HFS), and it has been argued that the only way to produce a scattering polarization signal in such lines is through the presence of a substantial amount of atomic polarization in their lower HFS levels. The strong sensitivity of these long-lived levels to depolarizing mechanisms led to the paradoxical conclusion that the observed D{sub 1}-line polarization is incompatible with the presence in the lower solar chromosphere of inclined magnetic fields sensibly stronger than 0.01 G. Here we show that by properly taking into account the fact that the solar D{sub 1}-line radiation has a non-negligible spectral structure over the short frequency interval spanned by the HFS transitions, it is possible to produce scattering polarization signals in the D{sub 1} lines of Na I and Ba II without the need of ground-level polarization. The resulting linear polarization is not so easily destroyed by elastic collisions and/or magnetic fields.

  17. Phase II DeCOG-Study of Ipilimumab in Pretreated and Treatment-Naïve Patients with Metastatic Uveal Melanoma

    PubMed Central

    Zimmer, Lisa; Vaubel, Julia; Mohr, Peter; Hauschild, Axel; Utikal, Jochen; Simon, Jan; Garbe, Claus; Herbst, Rudolf; Enk, Alexander; Kämpgen, Eckhart; Livingstone, Elisabeth; Bluhm, Leonie; Rompel, Rainer; Griewank, Klaus G.; Fluck, Michael; Schilling, Bastian; Schadendorf, Dirk

    2015-01-01

    Purpose Up to 50% of patients with uveal melanoma (UM) develop metastatic disease with limited treatment options. The immunomodulating agent ipilimumab has shown an overall survival (OS) benefit in patients with cutaneous metastatic melanoma in two phase III trials. As patients with UM were excluded in these studies, the Dermatologic Cooperative Oncology Group (DeCOG) conducted a phase II to assess the efficacy and safety of ipilimumab in patients with metastatic UM. Patients and Methods We undertook a multicenter phase II study in patients with different subtypes of metastatic melanoma. Here we present data on patients with metastatic UM (pretreated and treatment-naïve) who received up to four cycles of ipilimumab administered at a dose of 3 mg/kg in 3 week intervals. Tumor assessments were conducted at baseline, weeks 12, 24, 36 and 48 according to RECIST 1.1 criteria. Adverse events (AEs), including immune-related AEs were graded according to National Cancer Institute Common Toxicity Criteria (CTC) v.4.0. Primary endpoint was the OS rate at 12 months. Results Forty five pretreated (85%) and eight treatment-naïve (15%) patients received at least one dose of ipilimumab. 1-year and 2-year OS rates were 22% and 7%, respectively. Median OS was 6.8 months (95% CI 3.7–8.1), median progression-free survival 2.8 months (95% CI 2.5–2.9). The disease control rate at weeks 12 and 24 was 47% and 21%, respectively. Sixteen patients had stable disease (47%), none experienced partial or complete response. Treatment-related AEs were observed in 35 patients (66%), including 19 grade 3–4 events (36%). One drug-related death due to pancytopenia was observed. Conclusions Ipilimumab has very limited clinical activity in patients with metastatic UM. Toxicity was manageable when treated as per protocol-specific guidelines. Trial Registration ClinicalTrials.gov NCT01355120 PMID:25761109

  18. Mod II Stirling engine overviews

    NASA Technical Reports Server (NTRS)

    Farrell, Roger A.

    1988-01-01

    The Mod II engine is a second-generation automotive Stirling engine (ASE) optimized for part-power operation. It has been designed specifically to meet the fuel economy and exhaust emissions objectives of the ASE development program. The design, test experience, performance, and comparison of data to analytical performance estimates of the Mod II engine to date are reviewed. Estimates of Mod II performance in its final configuration are also given.

  19. PEP-II Alignment

    SciTech Connect

    Gaydosh, Michael

    2003-05-14

    The PEP-II Asymmetric B-factory consists of two independent storage rings, one located atop the other in the 2200m-circumference PEP tunnel. The high-energy ring, which stores a 9-GeV electron beam, is an upgrade of the existing PEP collider. It re-utilizes all of the PEP magnets and incorporates a state-of-the-art copper vacuum chamber and a new RF system capable of supporting a one-amp stored beam. The low-energy ring, which stores 3.1-GeV positrons, is new construction. Injection is achieved by extracting electrons and positrons at collision energies from the SLC and transporting them each in a dedicated bypass line. The low-emittance SLC beams will be used for the injection process.

  20. Phase II Final Report

    SciTech Connect

    Schuknecht, Nate; White, David; Hoste, Graeme

    2014-09-11

    The SkyTrough DSP will advance the state-of-the-art in parabolic troughs for utility applications, with a larger aperture, higher operating temperature, and lower cost. The goal of this project was to develop a parabolic trough collector that enables solar electricity generation in the 2020 marketplace for a 216MWe nameplate baseload power plant. This plant requires an LCOE of 9¢/kWhe, given a capacity factor of 75%, a fossil fuel limit of 15%, a fossil fuel cost of $6.75/MMBtu, $25.00/kWht thermal storage cost, and a domestic installation corresponding to Daggett, CA. The result of our optimization was a trough design of larger aperture and operating temperature than has been fielded in large, utility scale parabolic trough applications: 7.6m width x 150m SCA length (1,118m2 aperture), with four 90mm diameter × 4.7m receivers per mirror module and an operating temperature of 500°C. The results from physical modeling in the System Advisory Model indicate that, for a capacity factor of 75%: The LCOE will be 8.87¢/kWhe. SkyFuel examined the design of almost every parabolic trough component from a perspective of load and performance at aperture areas from 500 to 2,900m2. Aperture-dependent design was combined with fixed quotations for similar parts from the commercialized SkyTrough product, and established an installed cost of $130/m2 in 2020. This project was conducted in two phases. Phase I was a preliminary design, culminating in an optimum trough size and further improvement of an advanced polymeric reflective material. This phase was completed in October of 2011. Phase II has been the detailed engineering design and component testing, which culminated in the fabrication and testing of a single mirror module. Phase II is complete, and this document presents a summary of the comprehensive work.

  1. Analytical performance of the AtheNA MultiLyte ANA II assay in sera from lupus patients with multiple positive ANAs.

    PubMed

    Biagini, Raymond E; Parks, Christine G; Smith, Jerome P; Sammons, Deborah L; Robertson, Shirley A

    2007-06-01

    The purpose of this study was to evaluate the precision and accuracy of a commercial multiplexed kit for the measurement of 9 anti-nuclear antibodies (ANAs; anti-SS/A, anti-SS/B, anti-Sm, anti-RNP, anti-Jo-1, anti-Scl-70, anti-dsDNA, anti-Centromere B, and anti-Histone), and to compare these results to a subset of ANAs measured by enzyme-linked immunosorbent assays (ELISA) and immunodiffusion (ID). Sera were obtained from 22 systemic lupus erythematosus (SLE) patients, twelve controls and five others (commercial source) with various autoimmune diseases. ANA results from the AtheNA MultiLyte ANA II Assay (AtheNA) were compared to ELISA results (controls) and patients (ID). The AtheNA interassay coefficients of variation (CVs, N = 39, performed in duplicate; replicated 3x) ranged from 6.2% to 16.7% (mean = 9.8%), while the intra-assay CVs ranged from 5.8% to 14.3% (mean = 10.8%). Compared to results for SLE cases and controls, the sensitivity of AtheNA ranged from 85.7% to 100% (mean = 97.1%), while diagnostic specificity ranged from 16.7% to 100% (mean = 71.6%). There was significant agreement (P values ranging from 0.0001 to 0.03) when analytes coanalyzed by AtheNA and ELISA/ID were evaluated using Cohen's kappa (kappa values ranging from 0.376 to 1.000). No false positive ANA results were observed for either the control or commercial source autoimmune disease sera. These results indicate that the AtheNA assay is a precise and accurate alternative for performing multiple ELISAs or IDs in the diagnosis of autoimmune diseases, especially when the number of sera to be tested is large, such as in clinical screening or epidemiologic studies. It also appears that the AtheNA assay identifies positive ANA specificities which are missed by ID techniques, suggesting that it may have greater analytical sensitivity for some ANAs.

  2. Formation of layered Fe(II)-Al(III)-hydroxides during reaction of Fe(II) with aluminum oxide.

    PubMed

    Elzinga, Evert J

    2012-05-01

    The reactivity of aqueous Fe(II) with aluminum oxide in anoxic solutions was investigated with batch kinetic experiments combined with Fe K edge X-ray absorption spectroscopy measurements to characterize Fe(II) sorption products. Formation of Fe(II)-Al(III)-layered double hydroxides with an octahedral sheet structure similar to nikischerite (NaFe(II)(6) Al(3)(SO(4))(2)(OH)(18) (H(2)O)(12)) was observed within a few hours during sorption at pH 7.5 and aqueous Fe(II) concentrations of 1-3 mM. These Fe(II) phases are composed of brucite-like Fe(II)(OH)(2) sheets with partial substitution of Al(III) for Fe(II), charge balanced by anions coordinated along the basal planes. Their fast rate of formation suggests that these previously unrecognized Fe(II) phases, which are structurally and compositionally similar to green rust, may be an important sink of Fe(II) in suboxic and anoxic geochemical environments, and impact the fate of structurally compatible trace metals, such as Co(II), Ni(II), and Zn(II), as well as redox-reactive species including Cr(VI) and U(VI). Further studies are required to assess the thermodynamics, formation kinetics, and stability of these Fe(II) minerals under field conditions. PMID:22409244

  3. Crystal structure and magnetic properties of Na{sub 2}Ni{sup II}(HPO{sub 3}){sub 2}

    SciTech Connect

    Maalej, Wassim; Vilminot, Serge; Elaoud, Zakaria; Mhiri, Tahar; Kurmoo, Mohamedally

    2010-11-15

    Na{sub 2}Ni(HPO{sub 3}){sub 2}, obtained as light yellow-green crystals under mild hydrothermal conditions, crystallizes in the orthorhombic Pnma space-group with lattice parameters: a=11.9886(3), b=5.3671(2), c=9.0764(3) A, V=584.01 A{sup 3}, Z=4. The structure consists of zig-zag chains of NiO{sub 6} octahedra bridged by two HPO{sub 3}{sup 2-} and the chains are further connected through HPO{sub 3}{sup 2-} to four nearest chains to form a three dimensional framework, delimiting intersecting tunnels in which the sodium ions are located. The Na cations reside in the irregular Na(1)O{sub 5}, Na-O of 2.276-2.745 A, and Na(2)O{sub 9}, Na-O of 2.342-2.376 A, environments. The presence of the phosphite monoanion has been further confirmed by IR spectroscopy. Due to the 3D framework of Ni connected by O-P-O bridges, the magnetic susceptibility behaves as a paramagnet above 100 K (C=1.49(2) emu K mol{sup -1}, {mu}{sub eff}=3.45 {mu}{sub B}, {Theta}=-39(2) K) and below 6 K, it orders antiferromagnetically as confirmed the sharp drop and the non-Brillouin behavior of the isothermal magnetization at 2 K. - Graphical abstract: The structure of Na{sub 2}Ni(HPO{sub 3}){sub 2} consists of zig-zag chains of NiO{sub 6} octahedra bridged by two HPO{sub 3}{sup 2-} and the chains are further connected through HPO{sub 3}{sup 2-} to four nearest chains to form a three dimensional framework, delimiting intersecting tunnels in which the sodium ions are located. It orders antiferromagnetically at 6 K. Display Omitted

  4. Utilizing clouds for Belle II

    NASA Astrophysics Data System (ADS)

    Sobie, R. J.

    2015-12-01

    This paper describes the use of cloud computing resources for the Belle II experiment. A number of different methods are used to exploit the private and opportunistic clouds. Clouds are making significant contributions to the generation of Belle II MC data samples and it is expected that their impact will continue to grow over the coming years.

  5. PARIS II: DESIGNING GREENER SOLVENTS

    EPA Science Inventory

    PARIS II (the program for assisting the replacement of industrial solvents, version II), developed at the USEPA, is a unique software tool that can be used for customizing the design of replacement solvents and for the formulation of new solvents. This program helps users avoid ...

  6. [Modified Class II tunnel preparation].

    PubMed

    Rimondini, L; Baroni, C

    1991-05-15

    Tunnel preparations for restoration of Class II carious lesions in primary molars preserve the marginal ridge and minimize sacrifice of healthy tooth substructure. Materials with improved bonding to tooth structure and increase potential for fluoride release allow Class II restorations without "extension for prevention". PMID:1864420

  7. Technology II: Implementation Planning Guide.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Office of the Chancellor.

    The California Community Colleges (CCC) are facing a number of challenges, including the explosive use of the Internet, the digital divide, the need for integrating technology into teaching and learning, the impact of Tidal Wave II, and the need to ensure that technology is accessible to persons with disabilities. The CCCs' Technology II Strategic…

  8. ACRIM II Data and Information

    Atmospheric Science Data Center

    2015-12-30

    ACRIM II Data and Information Active Cavity Radiometer Irradiance ... and Order:   ASDC Order Tool FTP Web Access:  Data Pool Parameters:  Total Solar Irradiance ... ACRIM II Instrument Page ACRIM III Data Sets Readme Files:  Readme File Image ...

  9. Software Development at Belle II

    NASA Astrophysics Data System (ADS)

    Kuhr, Thomas; Hauth, Thomas

    2015-12-01

    Belle II is a next generation B-factory experiment that will collect 50 times more data than its predecessor Belle. This requires not only a major upgrade of the detector hardware, but also of the simulation, reconstruction, and analysis software. The challenges of the software development at Belle II and the tools and procedures to address them are reviewed in this article.

  10. National Synchrotron Light Source II

    ScienceCinema

    Steve Dierker

    2016-07-12

    The National Synchrotron Light Source II (NSLS-II) at the U.S. Department of Energy's Brookhaven National Laboratory is a proposed new state-of-the-art medium energy storage ring designed to deliver world-leading brightness and flux with top-off operation

  11. National Synchrotron Light Source II

    SciTech Connect

    Steve Dierker

    2008-03-12

    The National Synchrotron Light Source II (NSLS-II) at the U.S. Department of Energy's Brookhaven National Laboratory is a proposed new state-of-the-art medium energy storage ring designed to deliver world-leading brightness and flux with top-off operation

  12. Synthesis, Characterization, Spectral Studies and Antifungal Activity of Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) Complexes with 2-(4- Sulphophenylazo)-1,8-Dihydroxy-3,6-Napthalene Disulphonic Acid Trisodium Salt

    PubMed Central

    Pandey, Gajanan; Narang, K. K.

    2005-01-01

    Complexes of the type Na6[M(HL)2(H2O)2], where M= Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) and Na3H2L= 2-(4-sulphophenylazo)-1,8-dihydroxy 3,6 naphthalene disulphonic acid trisodium salt, have been synthesized and characterized by physico-chemical (elemental analyses, solubility, electrolytic conductance, magnetic susceptibility measurement) and spectral (UV-Visible, IR, ESR, powder x-ray diffraction) techniques for their structure and studied for their antifungal activity against ten fungi. The anionic 1:2 metal:ligand complexes show octahedral geometry around M(II), a significant antifungal activity against Curvularia lunata and Alternaria triticina and a moderate activity against Alternaria brassicicola, Alternaria brassicae, Alternaria solanae, Curvularia species, Helminthosporium oryzae, Collectotrichum capsici, Aspergillus niger, Aspergillus flavus and Fusarium udum. PMID:18365101

  13. Crystal Structure of Rat Carnitine Palmitoyltransferase II (CPT-II)

    SciTech Connect

    Hsiao,Y.; Jogl, G.; Esser, V.; Tong, L.

    2006-01-01

    Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the {beta}-oxidation of long-chain fatty acids in mitochondria. We report here the crystal structure of rat CPT-II at 1.9 Angstroms resolution. The overall structure shares strong similarity to those of short- and medium-chain carnitine acyltransferases, although detailed structural differences in the active site region have a significant impact on the substrate selectivity of CPT-II. Three aliphatic chains, possibly from a detergent that is used for the crystallization, were found in the structure. Two of them are located in the carnitine and CoA binding sites, respectively. The third aliphatic chain may mimic the long-chain acyl group in the substrate of CPT-II. The binding site for this aliphatic chain does not exist in the short- and medium-chain carnitine acyltransferases, due to conformational differences among the enzymes. A unique insert in CPT-II is positioned on the surface of the enzyme, with a highly hydrophobic surface. It is likely that this surface patch mediates the association of CPT-II with the inner membrane of the mitochondria.

  14. The Stark II reality.

    PubMed

    Memel, Sherwin L; Grosvenor, John C

    2003-02-01

    The long awaited final regulations in Phase I of a two-phase rulemaking process under the Stark II law were published on January 4, 2001. The Phase I final rules govern interpretation of the Stark law as it is applied to referrals by a physician for designated categories of health services to entities in which the referring physician has a financial interest. These new regulations are of particular concern to specialists, such as orthopaedic surgeons, whose practices are oriented to ancillary services that are considered designated health services, such as radiology, physical therapy and durable medical equipment, and where the availability of clear guidance is essential to ensure that medically necessary care is provided in a manner that complies with law. However, rather than the "brightline" guidance that the healthcare community sought, the new regulations create uncertainty in areas that had not existed before. The new regulations require physicians to evaluate the full range of their business and professional relationships to avoid the risk of nonpayment of claims, civil money penalties, or program exclusion after the effective date of the new regulations. PMID:12567126

  15. Angiotensin II receptor heterogeneity

    SciTech Connect

    Herblin, W.F.; Chiu, A.T.; McCall, D.E.; Ardecky, R.J.; Carini, D.J.; Duncia, J.V.; Pease, L.J.; Wong, P.C.; Wexler, R.R.; Johnson, A.L. )

    1991-04-01

    The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of the authors earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes. Autoradiographic studies demonstrated that all of the labeling of the rat adrenal was blocked by unlabeled AII or saralasin, but not by DuP 753. The predominant receptor in the rat adrenal cortex (80%) is sensitive to dithiothreitol (DTT) and DuP 753, and is designated AII-1. The residual sites in the adrenal cortex and almost all of the sites in the rat adrenal medulla are insensitive to both DTT and DuP 753, but were blocked by EXP655. These sites have been confirmed by ligand binding studies and are designated AII-2. The rabbit adrenal cortex is unique in yielding a nonuniform distribution of AII-2 sites around the outer layer of glomerulosa cells. In the rabbit kidney, the sites on the glomeruli are AII-1, but the sites on the kidney capsule are AII-2. Angiotensin III appears to have a higher affinity for AII-2 sites since it inhibits the binding to the rabbit kidney capsule but not the glomeruli. Elucidation of the distribution and function of these diverse sites should permit the development of more selective and specific therapeutic strategies.

  16. [Oculocutaneous type II tyrosinosis].

    PubMed

    Podglajen-Wecxsteen, O; Delaporte, E; Piette, F; le Flohic, X; Bergoend, H

    1993-01-01

    Richner-Hanhart syndrome, also called oculo-cutaneous tyrosinosis type II, is a recessive autosomal genodermatosis consecutive to a disorder of tyrosine metabolism. It presents as a varying association of palmo-plantar keratosis, bilateral keratitis and mental retardation. The authors report a new case which is atypical in that palmoplantar keratosis made a late appearance. The diagnosis was confirmed by the presence of hypertyrosinaemia, hypertyrosinuria and urinary excretion of phenolic acids, and the absence of hepato-renal lesion. Needle biopsy of the liver, which demonstrates the deficiency of soluble cytosolic tyrosine aminotransferase, is not indispensable to the diagnosis and was not performed in our patient. Treatment consisted of a dietary measure: a controlled phenylalanine and tyrosine intake to obtain a tyrosinaemia below 10 mg/100 ml. This resulted in a favourable and durable course of the oculo-cutaneous lesions. In case of isolated skin lesion, retinoids can be prescribed either alone of combined with a diet, making it less strict.

  17. The hydrolysis and precipitation of Pd(II) in 0.6 mol kg-1 NaCl: A potentiometric, spectrophotometric, and EXAFS study

    SciTech Connect

    Boily, Jean F.; Seward, Terry M.; Charnock, John M.

    2007-10-15

    The hydrolysis of palladium was investigated in 0.6 mol•kg-1 NaCl at 298.2 K. Potentiometric titrations of solutions at various total concentrations of palladium(II) revealed that dilute (millimolar) conditions can be used to monitor the proton release due to hydrolysis reactions up to 2 protons per palladium(II) as long as the equilibration time is kept small. Spectrophotometric titrations were used to corroborate the homogeneous changes in speciation for the PdCl3OH2- species and to extract its correlative molar absorption coefficients in the 210-320 nm range. The molar absorption coefficients are similar to those of PdCl42- but exhibit a broader distribution of excitation energies resulting from the blue shift of the dominant charge transfer bands due to the presence of OH-. The longer-term potentiometric titrations systematically yielded, on the other hand, precipitates which matured over a period of 6 weeks and resulted in a more extensive release of protons to the solution. Precipitation experiments at six different total palladium(II) concentrations in the 3-11 pH range showed the dominant precipitating phase as Pd(OH)1.72Cl0.28. The coordination environment of Pd in this solid was investigated by extended X-ray absorption fine structure spectroscopy (EXAFS) and yielded an average 1.75 O and 0.25 Cl per Pd atoms with a Pd-O distance of 2.0 Å and Pd-Cl of 2.1 Å. Finally, the precipitation experiments showed the final products to be of larger solubility than a literature Pd(OH)2 solubility study in which the KCl media induced a solid phase transformation to Pd(OH)1.72Cl0.28. Polynuclear complexes Pdq(OH)r2q-r with q=r=[3,9] explain the combined precipitation and hydrolysis data and may represent subsets of [Pd(OH)2]n and/or [Pd(OH)1.72Cl0.28]n chains coiled into nanometer-sized spheroids previously described in the literature.

  18. Angiotensin II modulates salty and sweet taste sensitivities.

    PubMed

    Shigemura, Noriatsu; Iwata, Shusuke; Yasumatsu, Keiko; Ohkuri, Tadahiro; Horio, Nao; Sanematsu, Keisuke; Yoshida, Ryusuke; Margolskee, Robert F; Ninomiya, Yuzo

    2013-04-10

    Understanding the mechanisms underlying gustatory detection of dietary sodium is important for the prevention and treatment of hypertension. Here, we show that Angiotensin II (AngII), a major mediator of body fluid and sodium homeostasis, modulates salty and sweet taste sensitivities, and that this modulation critically influences ingestive behaviors in mice. Gustatory nerve recording demonstrated that AngII suppressed amiloride-sensitive taste responses to NaCl. Surprisingly, AngII also enhanced nerve responses to sweeteners, but had no effect on responses to KCl, sour, bitter, or umami tastants. These effects of AngII on nerve responses were blocked by the angiotensin II type 1 receptor (AT1) antagonist CV11974. In behavioral tests, CV11974 treatment reduced the stimulated high licking rate to NaCl and sweeteners in water-restricted mice with elevated plasma AngII levels. In taste cells AT1 proteins were coexpressed with αENaC (epithelial sodium channel α-subunit, an amiloride-sensitive salt taste receptor) or T1r3 (a sweet taste receptor component). These results suggest that the taste organ is a peripheral target of AngII. The specific reduction of amiloride-sensitive salt taste sensitivity by AngII may contribute to increased sodium intake. Furthermore, AngII may contribute to increased energy intake by enhancing sweet responses. The linkage between salty and sweet preferences via AngII signaling may optimize sodium and calorie intakes. PMID:23575826

  19. Copper(II) and lead(II) sorption from aqueous solution by non-living Spirogyra neglecta.

    PubMed

    Singh, Alpana; Kumar, Dhananjay; Gaur, J P

    2007-12-01

    Dried biomass of Spirogyra neglecta rapidly sorbed the test metals and the process became saturated in 10-20min. Maximum sorption of Pb(II) [116.1mgg(-1)] and Cu(II) [115.3mgg(-1)] occurred at 0.1gl(-1) biomass and 100mgl(-1) metal concentration in the solution. Sorption of Cu(II) and Pb(II) occurred optimally at pH 4.5 and 5.0, respectively. Lead(II) and Cu(II) sorption were lesser from binary metal solution than from single metal solution. Lead(II) more severely inhibited Cu(II) sorption than vice versa thus reflecting greater affinity of Pb(II) for the biomass. NaOH pretreatment slightly enhanced the metal removal ability of the biomass. During repeated sorption/desorption cycles, Pb(II) and Cu(II) sorption decreased by 11% and 27%, respectively, at the end of the fifth cycle due inter alia to 10-15% loss of biomass. Nevertheless, Spirogyra appears to be a good sorbent for removing metals Cu(II) and Pb(II) from wastewaters.

  20. Oscillator strength measurements in samarium(II), neodymium(II) and praseodymium(II)

    NASA Astrophysics Data System (ADS)

    Li, Ruohong

    A knowledge of the abundances of lanthanide ions in stellar photospheres is valuable in astrophysics, especially for chemically peculiar stars. However, the determination of elemental abundances is often limited by inadequate knowledge of oscillator strengths. Combining independently measured values of radiative lifetimes and branching fractions is an effective and precise method to measure oscillator strengths. It avoids absolute intensity measurements, requiring a knowledge of the absolute number density of particles and absolute measurements of intensity, and furthermore decreases the systematic error greatly. In the previous work of our group, the lifetimes of Sm II, Nd II and Pr II were obtained. In this thesis work, we measured the corresponding branching fractions of these lanthanide ions using a fast-ion-beam laser-induced- fluorescence technique. The power of this technique is that ions are selectively excited by a laser, which ensures that every branch comes from a single upper level and gets rid of spectral blends. Besides, the low ion-beam density ensures that the systematic errors due to collisions and radiation trapping are negligible. Combining the branching fractions with our previously measured lifetimes, we obtained 608, 430 and 260 oscillator strength values for Sm II, Nd II and Pr II transitions, respectively, over the wavelength range 350-850 nm. These transitions originate from 69 upper levels in the range 21 655 cm -1 -29 388 cm -1 for Sm II, 46 upper levels in the range 22 697 cm -1 -29 955 cm -1 for Nd II, and 32 levels in the range 22 040 cm -1 -28 577 cm -1 for Pr II. Of the 260 measured oscillator strength values of Pr II, 183 have been determined accurately for the first time. The uncertainties arise principally from systematic uncertainties of the efficiency calibration of the optical detection system (7.1%), with smaller statistical contributions (1.5%). Comparisons are made to prior measurements.

  1. Options Study - Phase II

    SciTech Connect

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  2. Biosatellite II mission.

    PubMed

    Reynolds, O E

    1969-01-01

    Biosatellite B was launched from Cape Kennedy, Florida, on a two-stage DELTA launch vehicle at 6:04 p.m. on 7 September, 1967. Approximately nine minutes later the 435 kg spacecraft biological laboratory was placed into a satisfactory 315 km near-circular earth orbit, successfully separated from the launch vehicle's second stage and was designated Biosatellite II. The scientific payload consisting of thirteen selected general biology and radiation experiments were subjected to planned, carefully controlled environmental conditions during 45 hours of earth-orbital flight. The decision was made to abbreviate the scheduled 3-day mission by approximately one day because of a threatening tropical storm in the recovery area, and a problem of communication with the spacecraft from the tracking stations. Highest priority was placed on recovery which was essential to obtain the scientific results on all the experiments. The operational phase of the mission came to a successful conclusion with the deorbit of the recovery capsule, deployment of the parachute system and air recovery by the United States Air Force. The 127 kg recovery capsule was returned to biology laboratories at Hickam Air Force Base, Hawaii, for disassembly and immediate inspection and analysis of the biological materials by the experimenters. It was evident immediately that the quality of the biology was excellent and this fact gave promise of a high return of scientific data. The environmental conditions provided to the experimental material in the spacecraft, provisions for experimental controls, and operational considerations are presented as they relate to interpretation of the experimental results. PMID:11949687

  3. Photosystem II: evolutionary perspectives.

    PubMed Central

    Rutherford, A W; Faller, P

    2003-01-01

    Based on the current model of its structure and function, photosystem II (PSII) seems to have evolved from an ancestor that was homodimeric in terms of its protein core and contained a special pair of chlorophylls as the photo-oxidizable cofactor. It is proposed that the key event in the evolution of PSII was a mutation that resulted in the separation of the two pigments that made up the special chlorophyll pair, making them into two chlorophylls that were neither special nor paired. These ordinary chlorophylls, along with the two adjacent monomeric chlorophylls, were very oxidizing: a property proposed to be intrinsic to monomeric chlorophylls in the environment provided by reaction centre (RC) proteins. It seems likely that other (mainly electrostatic) changes in the environments of the pigments probably tuned their redox potentials further but these changes would have been minor compared with the redox jump imposed by splitting of the special pair. This sudden increase in redox potential allowed the development of oxygen evolution. The highly oxidizing homodimeric RC would probably have been not only inefficient in terms of photochemistry and charge storage but also wasteful in terms of protein or pigments undergoing damage due to the oxidative chemistry. These problems would have constituted selective pressures in favour of the lop-sided, heterodimeric system that exists as PSII today, in which the highly oxidized species are limited to only one side of the heterodimer: the sacrificial, rapidly turned-over D1 protein. It is also suggested that one reason for maintaining an oxidizable tyrosine, TyrD, on the D2 side of the RC, is that the proton associated with its tyrosyl radical, has an electrostatic role in confining P(+) to the expendable D1 side. PMID:12594932

  4. Biosatellite II mission.

    PubMed

    Reynolds, O E

    1969-01-01

    Biosatellite B was launched from Cape Kennedy, Florida, on a two-stage DELTA launch vehicle at 6:04 p.m. on 7 September, 1967. Approximately nine minutes later the 435 kg spacecraft biological laboratory was placed into a satisfactory 315 km near-circular earth orbit, successfully separated from the launch vehicle's second stage and was designated Biosatellite II. The scientific payload consisting of thirteen selected general biology and radiation experiments were subjected to planned, carefully controlled environmental conditions during 45 hours of earth-orbital flight. The decision was made to abbreviate the scheduled 3-day mission by approximately one day because of a threatening tropical storm in the recovery area, and a problem of communication with the spacecraft from the tracking stations. Highest priority was placed on recovery which was essential to obtain the scientific results on all the experiments. The operational phase of the mission came to a successful conclusion with the deorbit of the recovery capsule, deployment of the parachute system and air recovery by the United States Air Force. The 127 kg recovery capsule was returned to biology laboratories at Hickam Air Force Base, Hawaii, for disassembly and immediate inspection and analysis of the biological materials by the experimenters. It was evident immediately that the quality of the biology was excellent and this fact gave promise of a high return of scientific data. The environmental conditions provided to the experimental material in the spacecraft, provisions for experimental controls, and operational considerations are presented as they relate to interpretation of the experimental results.

  5. Retrovirus Epidemiology Donor Study-II (REDS-II)

    ClinicalTrials.gov

    2016-04-14

    Acquired Immunodeficiency Syndrome; Blood Donors; Blood Transfusion; HIV Infections; HIV-1; HIV-2; HTLV-I; HTLV-II; Retroviridae Infections; Hepatitis, Viral, Human; Hepatitis B; Hepacivirus; West Nile Virus

  6. New instruments at IPNS: POSY II and SAD II

    SciTech Connect

    Crawford, R.K.; Felcher, G.P.; Kleb, R.; Epperson, J.E.; Thiyagarajan, P.

    1988-09-29

    Three new instruments are currently in varying degrees of development/construction at IPNS. One of these, the Glass, Liquid, and Amorphous Materials Diffractometer (GLAD) is the subject of a separate paper in these Proceedings, and so will not be discussed further here. The other two, a second neutron reflectometer (POSY II) and a second small-angle diffractometer (SAD II) are described briefly below. 5 refs., 1 fig., 1 tab.

  7. Delta II commercial space transportation

    NASA Astrophysics Data System (ADS)

    Meyers, J. F.

    1988-07-01

    Delta II is an upgraded variant of the Delta family of launch vehicles that has been in use by NASA since 1960. Among the design improvements incorporated by Delta II is a cryogenic-propellant second stage, a 2.89-m diameter satellite-protecting nose fairing, graphite/epoxy solid rocket motor cases, and 12:1 main engine expansion nozzle. The manufacturer/operator offers Delta II customers a dedicated, single satellite launch capability fully tailored to the given spacecraft's unique mission requirements.

  8. SAM II Data and Information

    Atmospheric Science Data Center

    2016-07-06

    ... Data obtained from the Stratospheric Aerosol Measurement (SAM) II instrument, which flew on board the Nimbus-7 ... Spatial Resolution:  The altitude profiles of aerosol extinction have a 1 km vertical resolution. Temporal ...

  9. The Monomeric Pentacyanocobaltate (II) Anion.

    ERIC Educational Resources Information Center

    Mosha, Donnati M. S.

    1982-01-01

    Laboratory procedures, background information, and discussion of experimental results are provided for the preparation of Thallium (I) Pentacyanocobaltate (II). The preparation of this pale green salt is carried out in an aqueous medium. (Author/JN)

  10. Pregnancy and tyrosinaemia type II.

    PubMed

    Cerone, R; Fantasia, A R; Castellano, E; Moresco, L; Schiaffino, M C; Gatti, R

    2002-08-01

    A female patient with tyrosinaemia type II is reported having undergone two untreated pregnancies. During pregnancies, plasma tyrosine was raised. The outcomes of both offspring show that maternal tyrosinaemia may have an adverse effect on the developing fetus.

  11. Hydrothermal synthesis and characterization of a chromium(II) pyrophosphate, Na 2CrP 2O 7·0.5H 2O

    NASA Astrophysics Data System (ADS)

    Stock, N.; Férey, G.; Cheetham, A. K.

    2000-05-01

    The title compound, Na 2CrP 2O 7·0.5H 2O, was synthesized hydrothermally using chromium(II) acetate and tetrasodium pyrophosphate. The structure ( P2 1/ n, a=7.7033(2), b=10.0798(2), c=8.6667(2) Å, β=100.284(1)°, Z=4) was solved from single-crystal data (¯R1=0.0327, wR2=0.0785 ( I>2 σ( I))). The chromium is pentacoordinated by oxygen (4+1) with square pyramidal stereochemistry. Five of the seven oxygen atoms of the P 2O 74- ion are involved in the coordination of Cr 2+. Each P 2O 74- ions acts twice as a chelating ligand to two Cr 2+ ions forming two CrO 3P 2 rings. Thus, one-dimensional chains of alternating Cr 2+ and P 2O 74- ions are formed in which the chromium has a square-planar environment . These chains are connected to form sheets by coordination to an oxygen of an adjacent chain, thereby giving rise to the pentacoordinated stereochemistry of the Cr 2+. The compound exhibits Curie-Weiss paramagnetism between 6 and 300 K.

  12. One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.

    PubMed

    Shankaraiah, Nagula; Kumar, Niggula Praveen; Amula, Suresh Babu; Nekkanti, Shalini; Jeengar, Manish Kumar; Naidu, V G M; Reddy, T Srinivasa; Kamal, Ahmed

    2015-10-01

    A facile one-pot method for the synthesis of novel podophyllotoxin-thiourea congeners has been developed by using NH2SO3H/NaI system. Interestingly, 4β-azido podophyllotoxin reduction with concomitant aryl isothiocyanates coupling under mild reaction conditions has been achieved. These compounds have been investigated for their in vitro cytotoxicity against A549, MDA MB-231, DU-145, LNCaP, and HGC-27 cancer cell lines. Some of the representative compounds have selectively exhibited cytotoxicity on DU-145 (human prostate cancer) cells and the most potent compound was 4a (IC50 of 0.50 ± 0.03 μM) with optimal safety therapeutic window (81.7 fold) on normal human prostate cell line (RWPE-1, IC50 of 40.85 ± 0.78). The flow-cytometric analysis of the compound 4a in prostate cancer cells indicated a strong G2/M-phase arrest and significant topoisomerase II inhibition activity. Furthermore, these compounds induce apoptosis as observed by Acridine Orange and Ethidium Bromide (AO/EB) staining and Annexin V binding assay. Molecular docking results of the title compounds with topoisomerase-IIα were presented as theoretical support for the experimental data.

  13. Determination of fluid extraction and osmotic conductance sigma K in the lung with hypertonic NaCl infusion. II. Experiments.

    PubMed

    Hunter, M; Lee, J

    1992-11-01

    The change in venous blood density in an in vitro rabbit lung preparation was measured after the osmolarity of the blood was elevated 17 to 50 mosmol/liter by a constant arterial infusion of hypertonic saline. We observed a transient density decrease of the blood flowing from the lung and then a return to the preinfusion density within 10 sec, an indication of the rapid completion of fluid extraction from the interstitia by the elevation in osmotic pressure. By fitting the time course of the density change with the prediction of an extraction model, we obtained the osmotic conductance sigma K (the product of the reflection and filtration coefficient) of the lung due to the increase in NaCl osmotic pressure as 1.33 +/- 0.18 ml/[hr.(mosmol/liter).g wet lung tissue] (mean +/- SEM), the interstitial volume participating in the extraction process as 0.27 +/- 0.04 ml/g of lung tissue, and the volume of fluid extracted as 1.12 +/- 0.16 microliter/g tissue for every mosmol/liter elevation. Since we also found no significant difference between the osmotic extraction parameters determined in blood-perfused lungs and those determined in plasma-perfused lungs, we concluded that the rapid density change is the result of the fluid extraction and not the flow impediment of red blood cells caused by the increase in osmolarity. PMID:1479932

  14. Annex II technical documentation assessed.

    PubMed

    van Drongelen, A W; Roszek, B; van Tienhoven, E A E; Geertsma, R E; Boumans, R T; Kraus, J J A M

    2005-12-01

    Annex II of the Medical Device Directive (MDD) is used frequently by manufacturers to obtain CE-marking. This procedure relies on a full quality assurance system and does not require an assessment of the individual medical device by a Notified Body. An investigation into the availability and the quality of technical documentation for Annex II devices revealed severe shortcomings, which are reported here. PMID:16419921

  15. Kinetics and transport at AMTEC electrodes. II - Temperature dependence of the interfacial impedance of Na(g)/porous Mo/Na-Beta-double prime alumina

    NASA Technical Reports Server (NTRS)

    Williams, R. M.; Jeffries-Nakamura, B.; Underwood, M. L.; Bankston, C. P.; Kummer, J. T.

    1990-01-01

    The exchange current, transfer coefficient, mass-transport parameters, and electrode capacitance at the Na(g)/porous Mo/Na-Beta-double prime alumina solid electrolyte (BASE) phase boundary have been evaluated from 740 to 1220 K. The transfer coefficient exhibits a value close to 0.5 and the exchange current is dominated by collision frequency, with no significant activation energy. Since the porous Mp-electrode adopts a fairly regular microstructure on the BASE surface, the magnitude of the exchange current of mature electrodes directly depends on the actual contact zone of the porous metal film with the BASE ceramic, and decreases slightly as grain growth occurs. The exchange currents and the mass-transport parameters derived for very porous, thin Mo electrodes indicate that the charge-transfer reaction occurs at a small fraction of the interface. High-frequency limiting capacitance and resistance values due to the interface show potential dependence and a value on the order of 1 F/sq m and 0.1-1.0 Ohm-sq cm.

  16. Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

    PubMed

    Planells-Cases, R; Caprini, M; Zhang, J; Rockenstein, E M; Rivera, R R; Murre, C; Masliah, E; Montal, M

    2000-06-01

    Neural activity is crucial for cell survival and fine patterning of neuronal connectivity during neurodevelopment. To investigate the role in vivo of sodium channels (NaCh) in these processes, we generated knockout mice deficient in brain NaChalpha(II). NaChalpha(II)(-/-) mice were morphologically and organogenically indistinguishable from their NaChalpha(+/-) littermates. Notwithstanding, NaChalpha(II)(-/-) mice died perinatally with severe hypoxia and massive neuronal apoptosis, notably in the brainstem. Sodium channel currents recorded from cultured neurons of NaChalpha(II)(-/-) mice were sharply attenuated. Death appears to arise from severe hypoxia consequent to the brainstem deficiency of NaChalpha(II). NaChalpha(II) expression is, therefore, redundant for embryonic development but essential for postnatal survival.

  17. Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions.

    PubMed

    Danielsen, Andreas A; Parker, Mark D; Lee, Soojung; Boron, Walter F; Aalkjaer, Christian; Boedtkjer, Ebbe

    2013-03-22

    Activation of Na(+),HCO3(-) cotransport in vascular smooth muscle cells (VSMCs) contributes to intracellular pH (pH(i)) control during artery contraction, but the signaling pathways involved have been unknown. We investigated whether physical and functional interactions between the Na(+),HCO3(-) cotransporter NBCn1 (slc4a7) and the Ca(2+)/calmodulin-activated serine/threonine phosphatase calcineurin exist and play a role for pHi control in VSMCs. Using a yeast two-hybrid screen, we found that splice cassette II from the N terminus of NBCn1 interacts with calcineurin Aβ. When cassette II was truncated or mutated to disrupt the putative calcineurin binding motif PTVVIH, the interaction was abolished. Native NBCn1 and calcineurin Aβ co-immunoprecipitated from A7r5 rat VSMCs. A peptide (acetyl-DDIPTVVIH-amide), which mimics the putative calcineurin binding motif, inhibited the co-immunoprecipitation whereas a mutated peptide (acetyl-DDIATAVAA-amide) did not. Na(+),HCO3(-) cotransport activity was investigated in VSMCs of mesenteric arteries after an NH4(+) prepulse. During depolarization with 50 mM extracellular K(+) to raise intracellular [Ca(2+)], Na(+),HCO3(-) cotransport activity was inhibited 20-30% by calcineurin inhibitors (FK506 and cyclosporine A). FK506 did not affect Na(+),HCO3(-) cotransport activity in VSMCs when cytosolic [Ca(2+)] was lowered by buffering, nor did it disrupt binding between NBCn1 and calcineurin Aβ. FK506 augmented the intracellular acidification of VSMCs during norepinephrine-induced artery contractions. No physical or functional interactions between calcineurin Aβ and the Na(+)/H(+) exchanger NHE1 were observed in VSMCs. In conclusion, we demonstrate a physical interaction between calcineurin Aβ and cassette II of NBCn1. Intracellular Ca(2+) activates Na(+),HCO3(-) cotransport activity in VSMCs in a calcineurin-dependent manner which is important for protection against intracellular acidification.

  18. Adsorption of Cu(II), Ni(II) and Zn(II) on modified jute fibres.

    PubMed

    Shukla, S R; Pai, Roshan S

    2005-09-01

    The potential of a lignocellulosic fibre, jute, was assessed for adsorption of heavy metal ions like Cu(II), Ni(II) and Zn(II) from their aqueous solutions. The fibre was also used as adsorbent after chemically modifying it by two different techniques viz, loading of a dye with specific structure, C.I. Reactive Orange 13, and oxidising with hydrogen peroxide. Both the modified jute fibres gave higher metal ion adsorption. Thus, the dye loaded jute fibres showed metal ion uptake values of 8.4, 5.26 and 5.95 mg/g for Cu(II), Ni(II) and Zn(II), respectively, while the corresponding values for oxidised jute fibres were 7.73, 5.57 and 8.02 mg/g, as against 4.23, 3.37 and 3.55 mg/g for unmodified jute fibres. Adsorption isotherm models indicated best fit for Langmuir model for the modified jute fibres. The adsorption values decreased with lowering of pH. The desorption efficiency, regenerative and reuse capacity of these adsorbents were also assessed for three successive adsorption-desorption cycles. The adsorptive capacity was retained only when the caustic soda regeneration is carried out as an intermediate step after desorption. Possible mechanism has been given.

  19. CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1).

    PubMed

    Salceda, Emilio; Pérez-Castells, Javier; López-Méndez, Blanca; Garateix, Anoland; Salazar, Hector; López, Omar; Aneiros, Abel; Ständker, Ludger; Béress, Lászlo; Forssmann, Wolf-Georg; Soto, Enrique; Jiménez-Barbero, Jesús; Giménez-Gallego, Guillermo

    2007-08-15

    CgNa (Condylactis gigantea neurotoxin) is a 47-amino-acid- residue toxin from the giant Caribbean sea anemone Condylactis gigantea. The structure of CgNa, which was solved by 1H-NMR spectroscopy, is somewhat atypical and displays significant homology with both type I and II anemone toxins. CgNa also displays a considerable number of exceptions to the canonical structural elements that are thought to be essential for the activity of this group of toxins. Furthermore, unique residues in CgNa define a characteristic structure with strong negatively charged surface patches. These patches disrupt a surface-exposed cluster of hydrophobic residues present in all anemone-derived toxins described to date. A thorough characterization by patch-clamp analysis using rat DRG (dorsal root ganglion) neurons indicated that CgNa preferentially binds to TTX-S (tetrodotoxin-sensitive) voltage-gated sodium channels in the resting state. This association increased the inactivation time constant and the rate of recovery from inactivation, inducing a significant shift in the steady state of inactivation curve to the left. The specific structural features of CgNa may explain its weaker inhibitory capacity when compared with the other type I and II anemone toxins.

  20. 24 CFR 202.12 - Title II.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title II. 202.12 Section 202.12... INSTITUTIONS AND MORTGAGEES Title I and Title II Specific Requirements § 202.12 Title II. (a) Tiered pricing—(1... mortgagee approved for participation in Title II programs is notified by the Secretary that it had a rate...

  1. EBR-II Data Digitization

    SciTech Connect

    Yoon, Su-Jong; Rabiti, Cristian; Sackett, John

    2014-08-01

    1. Objectives To produce a validation database out of those recorded signals it will be necessary also to identify the documents need to reconstruct the status of reactor at the time of the beginning of the recordings. This should comprehends the core loading specification (assemblies type and location and burn-up) along with this data the assemblies drawings and the core drawings will be identified. The first task of the project will be identify the location of the sensors, with respect the reactor plant layout, and the physical quantities recorded by the Experimental Breeder Reactor-II (EBR-II) data acquisition system. This first task will allow guiding and prioritizing the selection of drawings needed to numerically reproduce those signals. 1.1 Scopes and Deliverables The deliverables of this project are the list of sensors in EBR-II system, the identification of storing location of those sensors, identification of a core isotopic composition at the moment of the start of system recording. Information of the sensors in EBR-II reactor system was summarized from the EBR-II system design descriptions listed in Section 1.2.

  2. A phase II study evaluating the toxicity and efficacy of single-agent temsirolimus in chemotherapy-naïve castration-resistant prostate cancer

    PubMed Central

    Kruczek, K; Ratterman, M; Tolzien, K; Sulo, S; Lestingi, T M; Nabhan, C

    2013-01-01

    Background: The mammalian target of rapamycin (mTOR) pathway is deregulated in castration-resistant prostate cancer (CRPC). We investigated the efficacy and toxicity of temsirolimus, an mTOR inhibitor, in chemotherapy-naïve CRPC. Methods: In this phase II open label study, eligible patients received IV temsirolimus at 25 mg weekly until objective disease progression, unacceptable toxicity or investigator's discretion. Toxicity was assessed every 4 weeks and responses every 8 weeks. Primary end point was calculating the overall response (OR) rate as well as measuring stable disease (SD) to assess the overall clinical benefit calculated as OR+SD. Secondary end points included prostatic-specific antigen (PSA) changes and time to progression biochemically and radiographically. Correlative studies included prospective assessment of quality of life (QoL) using two previously validated scales. Results: Although the sponsor halted the study early, 21 patients were enrolled of which, 15 were evaluable for efficacy and OR. Median age was 74 (range: 57–89), median PSA was 237.5 ng ml−1 (range: 8.2–2360), visceral disease present in 11 patients (52%), and 17 patients (81%) patients had Gleason score (7–10). Two patients had a partial response (PR) and eight had SD. The OR was 13% (2/15) and the overall clinical benefit (OR+SD) was 67% (10/15). Median time to radiographic disease progression was 2 months (range 2–10 months). Biochemical response assessment was available for 14/15 patients. Any PSA decline was observed in four patients (28.5% 4/14) with one patient (7%) having >50% PSA decline. Median time to progression by PSA was 2 months (range 1–10 months). With a median follow-up of 32 months, median overall survival (OS) was 13 months (range: 2–37) and three patients remain alive at the data cutoff (5/2013) for an OS of 14% at 4 years on an intent-to-treat analysis. Major non-haematologic toxicities included fatigue (19%) and pneumonia (14%). Main

  3. Proposed MIDAS II processing array

    SciTech Connect

    Meng, J.

    1982-03-01

    MIDAS (Modular Interactive Data Analysis System) is a ganged processor scheme used to interactively process large data bases occurring as a finite sequence of similar events. The existing device uses a system of eight ganged minicomputer central processor boards servicing a rotating group of 16 memory blocks. A proposal for MIDAS II, the successor to MIDAS, is to use a much larger number of ganged processors, one per memory block, avoiding the necessity of switching memories from processor to processor. To be economic, MIDAS II must use a small, relatively fast and inexpensive microprocessor, such as the TMS 9995. This paper analyzes the use of the TMS 9995 applied to the MIDAS II processing array, emphasizing computational, architectural and physical characteristics which make the use of the TMS 9995 attractive for this application.

  4. NSLS-II INJECTION CONCEPT.

    SciTech Connect

    SHAFTAN, T.; PINAYEV, I.; ROSE, J.; WANG, X.J.; ET AL.

    2005-05-16

    Currently the facility upgrade project is in progress at the NSLS (at Brookhaven National Laboratory). The goal of the NSLS-II is a 3 GeV ultra-low-emittance storage ring that will increase radiation brightness by three orders of magnitude over that of the present NSLS X-ray ring. The low emittance of the high brightness ring's lattice results in a short lifetime, so that a top-off injection mode becomes an operational necessity. Therefore, the NSLS-II injection system must provide, and efficiently inject, an electron beam at a high repetition rate. In this paper, we present our concept of the NSLS-II injection system and discuss the conditions for, and constraints on, its design.

  5. RTNS-II: present status

    SciTech Connect

    Heikkinen, D.W.; Logan, C.M.

    1980-10-01

    The present status of the RTNS-II facility is described and typical operating parameters are given. A brief discussion is given of the methods used in production of the TiT/sub 2/ targets as well as their performance and tritium handling at RTNS-II. The various types of non-interactive beam diagnostics presently in use at the neutron sources are outlined. The on-line computer system which provides a time history of an irradiation and records target performance is described. Examples are listed of several representative experimental programs which have been carried out thus far at RTNS-II. These include both active and passive experiments. Finally, several of the major improvements to the facility made since the beginning of the experimental program are given.

  6. Charm physics at CDF II

    SciTech Connect

    I. Furic

    2003-10-28

    The CDF II detector has the capability of triggering on displaced tracks. Because of this ability, CDF II has accrued large samples of charged meson decays to fully hadronic final states in 64 pb{sup -1} of p{bar p} collision data gathered at {radical}s = 1.96 TeV. Using initial Run II data samples, the production cross sections for J/{psi}, D{sup 0}, D{sup +}, D*{sup +} and D{sub s}{sup +} mesons have been measured. Ratios of branching ratios for Cabibbo suppressed final states and CP asymmetries in D{sup 0} meson decays have been studied. A measurement of the mass difference m(D{sub s}{sup +}) -m(D{sup +}) has been done, and a limit for the branching fraction of the FCNC D{sup 0} {yields} {mu}{sup +}{mu}{sup -} decays has been set.

  7. Cloning and characterization of a mitochondrial glyoxalase II from Brassica juncea that is upregulated by NaCl, Zn, and ABA

    SciTech Connect

    Saxena, Mukesh; Bisht, Rekha; Roy, Suchandra Deb; Sopory, S.K.; Bhalla-Sarin, Neera . E-mail: neerasarin@rediffmail.com

    2005-10-28

    A cDNA (1061 bp) Bj glyII was cloned from a mannitol induced library of Brassica juncea. It encoded a protein of 335 amino acids with a molecular weight of 36.52 kDa. The deduced amino acid sequence of the clone showed 92% and 56% identity with Pennisetum and rice glyoxalase II, respectively, and 30% identity was observed with the human glyoxalase II. Search for the identical residues revealed the presence of highly conserved THHHXDH domain which is involved in zinc binding. p-NN and pSORT analysis of this sequence revealed a N-terminal mitochondrial target peptide. The cDNA was cloned in pMAL and a fusion protein with MBP (78 kDa) was expressed in Escherichia coli. The recombinant protein was purified approximately sixfold by affinity purification on amylose column and showed its pH optima at 7.0. The K {sub m} was determined to be 120 {mu}M using S-D-lactoylglutathione as substrate. The expression of Bj glyII under various abiotic stress conditions showed that it is upregulated by salinity, heavy metal stress, and ABA.

  8. Propulsion Systems for Aircraft. Aerospace Education II. Instructional Unit II.

    ERIC Educational Resources Information Center

    Elmer, James D.

    This curriculum guide accompanies another publication in the Aerospace Education II series entitled "Propulsion Systems for Aircraft." The guide includes specific guidelines for teachers on each chapter in the textbook. Suggestions are included for objectives (traditional and behavioral), suggested outline, orientation, suggested key points,…

  9. The PEP-II design

    SciTech Connect

    Sullivan, M.K.

    1995-05-01

    The Stanford Linear Accelerator Center (SLAC), Lawrence Berkeley Laboratory (LBL), Lawrence Livermore National Laboratory (LLNL) Positron Electron Project-II (PEP-II) is a design for a high-luminosity, asymmetric energy, electron-positron colliding beam accelerator that will operate at the center-of-mass energy of the {Upsilon}4S (10.58 GeV). The goal of the design is to achieve a large enough integrated luminosity with a moving center-of-mass reference frame to he able to observe the predicted rare decay modes of the {Upsilon}4S that do not conserve charge parity (CP).

  10. Iron(II) PARACEST MRI contrast agents.

    PubMed

    Dorazio, Sarina J; Tsitovich, Pavel B; Siters, Kevin E; Spernyak, Joseph A; Morrow, Janet R

    2011-09-14

    The first examples of Fe(II) PARACEST magnetic resonance contrast agents are reported (PARACEST = paramagnetic chemical exchange saturation transfer). The iron(II) complexes contain a macrocyclic ligand, either 1,4,7-tris(carbamoylmethyl)-1,4,7-triazacyclononane (L1) or 1,4,7-tris[(5-amino-6-methyl-2-pyridyl)methyl]-1,4,7-triazacyclononane (L2). The macrocycles bind Fe(II) in aqueous solution with formation constants of log K = 13.5 and 19.2, respectively, and maintain the Fe(II) state in the presence of air. These complexes each contain six exchangeable protons for CEST which are amide protons in [Fe(L1)](2+) or amino protons in [Fe(L2)](2+). The CEST peak for the [Fe(L1)](2+) amide protons is at 69 ppm downfield of the bulk water resonance whereas the CEST peak for the [Fe(L2)](2+) amine protons is at 6 ppm downfield of bulk water. CEST imaging using a MRI scanner shows that the CEST effect can be observed in solutions containing low millimolar concentrations of complex at neutral pH, 100 mM NaCl, 20 mM buffer at 25 °C or 37 °C.

  11. Probing Our Heliospheric History II

    NASA Astrophysics Data System (ADS)

    Wyman, Katherine; Redfield, S.

    2012-05-01

    A physical relationship between our local interstellar medium (ISM), galactic cosmic rays (GCR), and our planetary environment has long been a subject of interest to the astronomical community. Clouds of sufficient density to compress the heliosphere to within 1 AU are commonly seen throughout the galactic environment, including within the Local Bubble (LB). Such a compression would lead to an increase in the GCR flux at 1 AU and would have drastic consequences for many planetary processes such as atmospheric chemistry, lightning production, cloud cover, and DNA mutation rates for surface organisms. Prior to this work, we derived a column density profile of the ISM toward 49 bright stars along a narrow cone centered on the historical solar path. High resolution spectra were taken of NaI and CaII absorption out to a distance of 610 pc, with a median separation distance of 11 pc between adjacent stars. No absorption is seen out to a distance of 120 pc (consistent with the LB), but a complex number of absorbers is seen beyond. We now present the detection of several distinct clouds, their associated column densities, radial velocities, inferred distances, and size constraints. This combination of cloud properties allows us to derive a volume density profile of the ISM in the Sun's “rear-view mirror,” which represents one plausible record of actual ISM encounters for the Sun. We also make use of empirical relations to determine the effect these clouds would have on the historical heliosphere. Our analysis suggests that within the last 10 million years, if the Sun encountered a cloud with the same properties as we have detected along the solar historical trajectory, the Sun's termination shock would have resided inside the orbit of Uranus, with a GCR flux at Earth an order of magnitude greater than it is currently.

  12. Case 22:Type II diabetes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Diabetes mellitus is characterized by elevated blood glucose levels. It is composed of two types depending on the pathogenesis. Type I diabetes is characterized by insulin deficiency and usually has its onset during childhood or teenage years. This is also called ketosis-prone diabetes. Type II diab...

  13. RARE II: The Administration's View

    ERIC Educational Resources Information Center

    Cutler, M. Rupert

    1977-01-01

    RARE II is a new Roadless Area Review and Evaluation of the National Forest system. Administrators are attempting to inventory existing wilderness areas and to determine criteria for setting aside additional ones. This information will be used for the required 1980 update of the national assessment of forests and rangelands. (MA)

  14. Type-II Weyl semimetals.

    PubMed

    Soluyanov, Alexey A; Gresch, Dominik; Wang, Zhijun; Wu, QuanSheng; Troyer, Matthias; Dai, Xi; Bernevig, B Andrei

    2015-11-26

    Fermions--elementary particles such as electrons--are classified as Dirac, Majorana or Weyl. Majorana and Weyl fermions had not been observed experimentally until the recent discovery of condensed matter systems such as topological superconductors and semimetals, in which they arise as low-energy excitations. Here we propose the existence of a previously overlooked type of Weyl fermion that emerges at the boundary between electron and hole pockets in a new phase of matter. This particle was missed by Weyl because it breaks the stringent Lorentz symmetry in high-energy physics. Lorentz invariance, however, is not present in condensed matter physics, and by generalizing the Dirac equation, we find the new type of Weyl fermion. In particular, whereas Weyl semimetals--materials hosting Weyl fermions--were previously thought to have standard Weyl points with a point-like Fermi surface (which we refer to as type-I), we discover a type-II Weyl point, which is still a protected crossing, but appears at the contact of electron and hole pockets in type-II Weyl semimetals. We predict that WTe2 is an example of a topological semimetal hosting the new particle as a low-energy excitation around such a type-II Weyl point. The existence of type-II Weyl points in WTe2 means that many of its physical properties are very different to those of standard Weyl semimetals with point-like Fermi surfaces.

  15. Recent results from DORIS II

    SciTech Connect

    Bloom, E.D.

    1985-01-01

    This report contains a brief review of recent results from the ARGUS and Crystal Ball experiments at DORIS II, concentrating on UPSILON(1S) and UPSILON(2S) spectroscopy with a short foray into ..gamma gamma.. physics. 18 refs., 10 figs.

  16. Solar Ca II K Observations

    NASA Astrophysics Data System (ADS)

    Bertello, Luca; Pevtsov, Alexei A.; Tlatov, Andrey; Singh, Jagdev

    2016-07-01

    Some of the most important archives of past and current long-term solar synoptic observations in the resonance line of Ca II K are described here. These observations are very important for understanding the state of the solar magnetism on time scales up to several decades. The first observations of this kind began in 1904 at the Kodaikanal Observatory (India), followed by similar programs at different other locations. Regular full-disk Ca II K monitoring programs started in 1915 at the Mount Wilson Observatory (USA) and in 1917 at the National Solar Observatory of Japan. Beginning in 1919 and in 1926 regular observations were taken also at the Paris-Meudon Observatory (France) and at the "Donati solar tower telescope of the Arcetri Astrophysical Observatory in Italy, respectively. In 1926 the the Astronomical Observatory of the Coimbra University in Portugal started its own program of Ca II K observations. Although some of these programs have been terminated over the years, their data archives constitute a unique resource for studies of solar variability. In the early 1970s, the National Solar Observatory (NSO) at Sacramento Peak (USA) started a new program of daily Sun-as-a-star observations in the Ca II K line. Today the NSO is continuing these observations through its Synoptic Optical Long-term Investigations of the Sun (SOLIS) facility.

  17. Tech Area II: A history

    SciTech Connect

    Ullrich, R.

    1998-07-01

    This report documents the history of the major buildings in Sandia National Laboratories` Technical Area II. It was prepared in support of the Department of Energy`s compliance with Section 106 of the National Historic Preservation Act. Technical Area II was designed and constructed in 1948 specifically for the final assembly of the non-nuclear components of nuclear weapons, and was the primary site conducting such assembly until 1952. Both the architecture and location of the oldest buildings in the area reflect their original purpose. Assembly activities continued in Area II from 1952 to 1957, but the major responsibility for this work shifted to other sites in the Atomic Energy Commission`s integrated contractor complex. Gradually, additional buildings were constructed and the original buildings were modified. After 1960, the Area`s primary purpose was the research and testing of high-explosive components for nuclear weapons. In 1994, Sandia constructed new facilities for work on high-explosive components outside of the original Area II diamond-shaped parcel. Most of the buildings in the area are vacant and Sandia has no plans to use them. They are proposed for decontamination and demolition as funding becomes available.

  18. TREC Initiative with Cheshire II.

    ERIC Educational Resources Information Center

    Larson, Ray R.

    2001-01-01

    Describes the University of California at Berkeley's participation in the TREC (Text Retrieval Conference) interactive track experiments. Highlights include results of searches on two systems, Cheshire II and ZPRISE; system design goals and implementation; precision and recall results; search questions by topic and system; and results of…

  19. 40 K Fastrac II Test

    NASA Technical Reports Server (NTRS)

    1997-01-01

    A 40 K Fastrac II duration test performed at Marshall Test Stand 116. The purpose of this test was to gauge the length of time between contact of TEA (Triethylenealuminum) and LOX (liquid oxygen) as an ignitor for the Fastrac engine.

  20. Achondrogenesis type II with polydactyly.

    PubMed

    Rittler, M; Orioli, I M

    1995-11-01

    We report on a newborn male infant who presented the typical findings of achondrogenesis type II (Langer-Saldino), and who also showed postaxial polydactyly on both feet and bilateral microtia. Polydactyly is frequently part of the short-rib syndromes, but has not been reported in achondrogenesis. The hypothesis of polydactyly as part of a contiguous gene syndrome is discussed. PMID:8588578

  1. Military Aerospace. Aerospace Education II.

    ERIC Educational Resources Information Center

    Smith, J. C.

    This book is a revised publication in the series on Aerospace Education II. It describes the employment of aerospace forces, their methods of operation, and some of the weapons and equipment used in combat and combat support activities. The first chapter describes some of the national objectives and policies served by the Air Force in peace and…

  2. Outcome in tyrosinaemia type II.

    PubMed

    Barr, D G; Kirk, J M; Laing, S C

    1991-10-01

    Tyrosinaemia type II was diagnosed in a boy with failure to thrive and in his sister on neonatal screening. On diet the outcome, at 12 and 10 years respectively, has been excellent in respect of oculocutaneous sequelae, growth, and psychomotor development, contrasting with the generally unfavourable outcome in most reported cases.

  3. Application Programming in AWIPS II

    NASA Technical Reports Server (NTRS)

    Smit, Matt; McGrath, Kevin; Burks, Jason; Carcione, Brian

    2012-01-01

    Since its inception almost 8 years ago, NASA's Short-term Prediction Research and Transition (SPoRT) Center has integrated NASA data into the National Weather Service's decision support system (DSS) the Advanced Weather Interactive Processing System (AWIPS). SPoRT has, in some instances, had to shape and transform data sets into various formats and manipulate configurations to visualize them in AWIPS. With the advent of the next generation of DSS, AWIPS II, developers will be able to develop their own plugins to handle any type of data. Raytheon is developing AWIPS II to be a more extensible package written mainly in Java, and built around a Service Oriented Architecture. A plugin architecture will allow users to install their own code modules, and (if all the rules have been properly followed) they will work hand-in-hand with AWIPS II as if it were originally built in. Users can bring in new datasets with existing plugins, tweak plugins to handle a nuance or desired new functionality, or create an entirely new visualization layout for a new dataset. SPoRT is developing plugins to ensure its existing NASA data will be ready for AWIPS II when it is delivered, and to prepare for the future of new instruments on upcoming satellites.

  4. NSLS-II RF SYSTEMS

    SciTech Connect

    Rose, J.; Gash, W.; Holub, B.; Kawashima, Y.; Ma, H.; Towne, N.; Yeddulla, M.

    2011-03-28

    The NSLS-II is a new third generation light source being constructed at Brookhaven Lab. The storage ring is optimized for low emittance by use of damping wigglers to reduce the emittance to below 1 nm-rad. The RF systems are designed to provide stable beam through tight RF phase and amplitude stability requirements.

  5. Diversity of parasite complex II.

    PubMed

    Harada, Shigeharu; Inaoka, Daniel Ken; Ohmori, Junko; Kita, Kiyoshi

    2013-05-01

    Parasites have developed a variety of physiological functions necessary for completing at least part of their life cycles in the specialized environments of surrounding the parasites in the host. Regarding energy metabolism, which is essential for survival, parasites adapt to the low oxygen environment in mammalian hosts by using metabolic systems that are very different from those of the hosts. In many cases, the parasite employs aerobic metabolism during the free-living stage outside the host but undergoes major changes in developmental control and environmental adaptation to switch to anaerobic energy metabolism. Parasite mitochondria play diverse roles in their energy metabolism, and in recent studies of the parasitic nematode, Ascaris suum, the mitochondrial complex II plays an important role in anaerobic energy metabolism of parasites inhabiting hosts by acting as a quinol-fumarate reductase. In Trypanosomes, parasite complex II has been found to have a novel function and structure. Complex II of Trypanosoma cruzi is an unusual supramolecular complex with a heterodimeric iron-sulfur subunit and seven additional non-catalytic subunits. The enzyme shows reduced binding affinities for both substrates and inhibitors. Interestingly, this structural organization is conserved in all trypanosomatids. Since the properties of complex II differ across a wide range of parasites, this complex is a potential target for the development of new chemotherapeutic agents. In this regard, structural information on the target enzyme is essential for the molecular design of drugs. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease. PMID:23333273

  6. Comparative studies of aerosol extinction measurements made by the SAM II and SAGE II satellite experiments

    NASA Technical Reports Server (NTRS)

    Yue, Glenn K.; Mccormick, M. P.; Chu, W. P.; Wang, P.; Osborn, M. T.

    1989-01-01

    Results from the Stratospheric Aerosol Measurement (SAM) II and Stratospheric Aerosol and Gas Experiment (SAGE) II are compared for measurement locations which are coincident in time and space. At 1.0 micron, the SAM II and SAGE II aerosol extinction profiles are similar within their measurement errors. In addition, sunrise and sunset aerosol extinction data at four different wavelengths are compared for occasions when the SAGE II and SAM II measurements are nearly coincident in space and about 12 hours apart.

  7. Synthesis, spectroscopic, antimicrobial and DNA cleavage studies of new Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes with naphthofuran-2-carbohydrazide Schiff base

    NASA Astrophysics Data System (ADS)

    Halli, Madappa B.; Sumathi, R. B.

    2012-08-01

    A series of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and Hg(II) complexes have been synthesized with newly synthesized Schiff base derived from naphthofuran-2-carbohydrazide and cinnamaldehyde. The elemental analyses of the complexes are confined to the stoichiometry of the type MLCl2 [M = Co(II) and Cu(II)], ML2Cl2 [M = Ni(II), Cd(II), Zn(II) and Hg(II)] respectively, where L is Schiff base ligand. Structures have been proposed from elemental analyses, IR, electronic, mass, 1H NMR, ESR spectral data, magnetic, and thermal studies. The measured low molar conductance values in DMF indicate that the complexes are non-electrolytes. Spectroscopic studies suggest coordination occurs through azomethine nitrogen and carbonyl oxygen of the ligand with the metal ions. The Schiff base and its complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal (Aspergillus niger, Aspergillus flavus, Cladosporium and Candida albicans) activities by minimum inhibitory concentration (MIC) method. The DNA cleavage studies by agarose gel electrophoresis method was studied for all the complexes.

  8. Adsorption of Pb(II), Cu(II), Cd(II), Zn(II), Ni(II), Fe(II), and As(V) on bacterially produced metal sulfides.

    PubMed

    Jong, Tony; Parry, David L

    2004-07-01

    The adsorption of Pb(II), Cu(II), Cd(II), Zn(II), Ni(II), Fe(II) and As(V) onto bacterially produced metal sulfide (BPMS) material was investigated using a batch equilibrium method. It was found that the sulfide material had adsorptive properties comparable with those of other adsorbents with respect to the specific uptake of a range of metals and, the levels to which dissolved metal concentrations in solution can be reduced. The percentage of adsorption increased with increasing pH and adsorbent dose, but decreased with increasing initial dissolved metal concentration. The pH of the solution was the most important parameter controlling adsorption of Cd(II), Cu(II), Fe(II), Ni(II), Pb(II), Zn(II), and As(V) by BPMS. The adsorption data were successfully modeled using the Langmuir adsorption isotherm. Desorption experiments showed that the reversibility of adsorption was low, suggesting high-affinity adsorption governed by chemisorption. The mechanism of adsorption for the divalent metals was thought to be the formation of strong, inner-sphere complexes involving surface hydroxyl groups. However, the mechanism for the adsorption of As(V) by BPMS appears to be distinct from that of surface hydroxyl exchange. These results have important implications to the management of metal sulfide sludge produced by bacterial sulfate reduction.

  9. Sloan Digital Sky Survey II (SDSS-II) Supernova Data

    DOE Data Explorer

    The Sloan Digital Sky Survey (SDSS) is a series of three interlocking imaging and spectroscopic surveys, carried out over an eight-year period with a dedicated 2.5m telescope located at Apache Point Observatory in Southern New Mexico. The SDSS Supernova Survey was one of those three components of SDSS and SDSS-II, a 3-year extension of the original SDSS that operated from July 2005 to July 2008. The Supernova Survey was a time-domain survey, involving repeat imaging of the same region of sky every other night, weather permitting. The primary scientific motivation was to detect and measure light curves for several hundred supernovae through repeat scans of the SDSS Southern equatorial stripe 82 (about 2.5? wide by ~120? long). Over the course of three 3-month campaigns SDSS-II SN discovered and measured multi-band lightcurves for ~500 spectroscopically confirmed Type Ia supernovae in the redshift range z=0.05-0.4. In addition, the project harvested a few hundred light curves for SNe Ia and discovered about 80 spectroscopically confirmed core-collapse supernovae (supernova types Ib/c and II).

  10. Solid phase extraction of lead (II), copper (II), cadmium (II) and nickel (II) using gallic acid-modified silica gel prior to determination by flame atomic absorption spectrometry.

    PubMed

    Xie, Fazhi; Lin, Xucong; Wu, Xiaoping; Xie, Zenghong

    2008-01-15

    The immobilization of gallic acid on the surface of amino group-containing silica gel phases for the formation of a newly chelating matrix (GASG) is described. The newly synthesized extractant, characterized by the diffuse reflectance infrared Fourier transformation spectroscopy and elemental analysis, was used to preconcentrate Pb(II), Cu(II), Cd(II) and Ni(II). The pH ranges for quantitative sorption and the concentrations of HCl for eluting Pb(II), Cd(II), Cu(II) and Ni(II) were opimized, respectively. The sorption capacity of the matrix has been found to be 12.63, 6.09, 15.38, 4.62mg/g for Pb(II), Cd(II), Cu(II) and Ni(II), respectively, with the preconcentration factor of approximately 200 ( approximately 100 for Cd(II)). The effects of flow rates, the eluants, the electrolytes and cations on the metal ions extraction, as well as the chelating matrix stability and reusability, were also studied. The extraction behavior of the matrix was conformed with Langmuir's equation. The present preconcentration and determination method was successfully applied to the analysis of synthetic metal mixture solution and river water samples. The 3sigma detection limit and 10sigma quantification limit for Pb(II), Cu(II), Cd(II) and Ni(II) were found to be 0.58, 0.86, 0.65, 0.92microg/L and 1.08, 1.23, 0.87, 1.26microg/L, respectively. PMID:18371717

  11. Removal of Ni(II), Zn(II) and Pb(II) ions from single metal aqueous solution using rice husk-based activated carbon

    SciTech Connect

    Taha, Mohd F. Shaharun, Maizatul S.; Shuib, Anis Suhaila Borhan, Azry

    2014-10-24

    An attempt was made to investigate the potential of rice husk-based activated carbon as an alternative low-cost adsorbent for the removal of Ni(II), Zn(II) and Pb(II) ions from single aqueous solution. Rice husk-based activated carbon was prepared via treatment of rice husk with NaOH followed by the carbonization process at 400°C for 2 hours. Three samples, i.e. raw rice husk, rice husk treated with NaOH and rice husk-based activated carbon, were analyzed for their morphological characteristics using field-emission scanning electron microscope/energy dispersive X-ray (FESEM/EDX). These samples were also analyzed for their carbon, hydrogen, nitrogen, oxygen and silica contents using CHN elemental analyzer and FESEM/EDX. The porous properties of rice husk-based activated carbon were determined by Brunauer-Emmett-Teller (BET) surface area analyzer, and its surface area and pore volume were 255 m{sup 2}/g and 0.17 cm{sup 2}/g, respectively. The adsorption studies for the removal of Ni(II), Zn(II) and Pb(II) ions from single metal aqueous solution were carried out at a fixed initial concentration of metal ion (150 ppm) with variation amount of adsorbent (rice husk-based activated carbon) as a function of varied contact time at room temperature. The concentration of each metal ion was analyzed using atomic absorption spectrophotometer (AAS). The results obtained from adsorption studies indicate the potential of rice husk as an economically promising precursor for the preparation of activated carbon for removal of Ni(II), Zn(II) and Pb(II) ions from single aqueous solution. Isotherm and kinetic model analyses suggested that the experimental data of adsorption studies fitted well with Langmuir, Freundlich and second-order kinetic models.

  12. SAM II Data and Information (ASCII)

    Atmospheric Science Data Center

    2016-09-01

    SAM II (ASCII) Data and Information Data obtained from the Stratospheric Aerosol Measurement (SAM) II instrument, ... Guide Documents:  Project Guide Data Set Guide Readme Files:  Data Set (Text file) ...

  13. Type-II Quantum Computers

    NASA Astrophysics Data System (ADS)

    Yepez, Jeffrey

    This paper discusses a computing architecture that uses both classical parallelism and quantum parallelism. We consider a large parallel array of small quantum computers, connected together by classical communication channels. This kind of computer is called a type-II quantum computer, to differentiate it from a globally phase-coherent quantum computer, which is the first type of quantum computer that has received nearly exclusive attention in the literature. Although a hybrid, a type-II quantum computer retains the crucial advantage allowed by quantum mechanical superposition that its computational power grows exponentially in the number of phase-coherent qubits per node, only short-range and short time phase-coherence is needed, which significantly reduces the level of engineering facility required to achieve its construction. Therefore, the primary factor limiting its computational power is an economic one and not a technological one, since the volume of its computational medium can in principle scale indefinitely.

  14. First results from SAGE II

    SciTech Connect

    Aburashitov, J.N.; Faizov, E.L.; Gavrin, V.N.; Gusev, A.O.; Kalikhov, A.V.; Knodel, T.V.; Knyshenko, I.I.; Kornoukhov, V.N.; Mirmov, I.N.; Pshukov, A.M.; Shalagin, A.M.; Shikhin, A.A.; Timofeyev, P.V.; Veretenkin, E.P.; Vermul, V.M.; Zatsepin, G.T.; Bowles, T.J.; Nico, J.S.; Teasdale, W.A.; Wark, D.L.; Wilkerson, J.F.; Cleveland, B.T.; Daily, T.; Davis, R. Jr.; Lande, K.; Lee, C.K.; Wildenhain, P.W.; Elliott, S.R.; Cherry, M.L.

    1995-07-10

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76{sup +21}{sub {minus}18}(stat){sup +5}{sub {minus}7}(sys) SNU. Combined with the SAGE I result, the capture rate is 74{sup +13}{sub {minus}12}(stat){sup +5}{sub {minus}7}(sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  15. Belle II silicon vertex detector

    NASA Astrophysics Data System (ADS)

    Adamczyk, K.; Aihara, H.; Angelini, C.; Aziz, T.; Babu, V.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, Ti.; Baroncelli, To.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bergauer, T.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Casarosa, G.; Ceccanti, M.; Červenkov, D.; Chendvankar, S. R.; Dash, N.; Divekar, S. T.; Doležal, Z.; Dutta, D.; Enami, K.; Forti, F.; Friedl, M.; Hara, K.; Higuchi, T.; Horiguchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C. W.; Kandra, J.; Kang, K. H.; Kato, E.; Kawasaki, T.; Kodyš, P.; Kohriki, T.; Koike, S.; Kolwalkar, M. M.; Kvasnička, P.; Lanceri, L.; Lettenbicher, J.; Maki, M.; Mammini, P.; Mayekar, S. N.; Mohanty, G. B.; Mohanty, S.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Negishi, K.; Nisar, N. K.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Pilo, F.; Profeti, A.; Rashevskaya, I.; Rao, K. K.; Rizzo, G.; Rozanska, M.; Sandilya, S.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Seino, Y.; Shimizu, N.; Stypula, J.; Suzuki, J.; Tanaka, S.; Tanida, K.; Taylor, G. N.; Thalmeier, R.; Thomas, R.; Tsuboyama, T.; Uozumi, S.; Urquijo, P.; Vitale, L.; Volpi, M.; Watanuki, S.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Würkner, B.; Yamamoto, H.; Yin, H.; Yoshinobu, T.

    2016-09-01

    The Belle II experiment at the SuperKEKB collider in Japan is designed to indirectly probe new physics using approximately 50 times the data recorded by its predecessor. An accurate determination of the decay-point position of subatomic particles such as beauty and charm hadrons as well as a precise measurement of low-momentum charged particles will play a key role in this pursuit. These will be accomplished by an inner tracking device comprising two layers of pixelated silicon detector and four layers of silicon vertex detector based on double-sided microstrip sensors. We describe herein the design, prototyping and construction efforts of the Belle-II silicon vertex detector.

  16. [Tyrosinemia type II. Case report].

    PubMed

    Benatiya, A I; Bouayed, M A; Touiza, E; Daoudi, K; Bhalil, S; Elmesbahi, I; Tahri, H

    2005-01-01

    Tyrosinemia type II or Richner-Hanhart syndrome is a rare hereditary disease characterized by the association of pseudoherpetiform corneal ulcerations and palmoplantar hyperkeratosis. We report the case of a 12 year-old young man presenting a superficial punctate keratitis and a corneal dystrophy in both eyes, associated with a palmoplantar hyperkeratosis. The dosage of the serum level of tyrosine is meaningfully raised to 1236 micromol/l. A dietary treatment restraining tyrosine and phenylalanine is started with favorable results after an evolution of 6 months. Tyrosinemia type II is an autosomal recessive disease, due to an enzymatic deficit in tyrosine aminotransferase. The diagnosis is based on the clinic and high level of serum and urinary tyrosine as well as of its urinary metabolites. This disease must be suspected in all cases of dentritic keratitis not reacting on the antiviral treatment, and more especially if it is associated with cutaneous lesions such as palmo-plantar keratosis.

  17. Jefferson Lab's Trim Card II

    SciTech Connect

    Trent Allison; Sarin Philip; C. Higgins; Edward Martin; William Merz

    2005-05-01

    Jefferson Lab's Continuous Electron Beam Accelerator Facility (CEBAF) uses Trim Card I power supplies to drive approximately 1900 correction magnets. These trim cards have had a long and illustrious service record. However, some of the employed technology is now obsolete, making it difficult to maintain the system and retain adequate spares. The Trim Card II is being developed to act as a transparent replacement for its aging predecessor. A modular approach has been taken in its development to facilitate the substitution of sections for future improvements and maintenance. The resulting design has been divided into a motherboard and 7 daughter cards which has also allowed for parallel development. The Trim Card II utilizes modern technologies such as a Field Programmable Gate Array (FPGA) and a microprocessor to embed trim card controls and diagnostics. These reprogrammable devices also provide the versatility to incorporate future requirements.

  18. Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium

    PubMed Central

    Shu, Shi; Liu, Xiong; Korn, Edward D.

    2005-01-01

    Blebbistatin, a cell-permeable inhibitor of class-II myosins, was developed to provide a tool for studying the biologic roles of myosin II. Consistent with this use, we find that blebbistatin inhibits three myosin II-dependent processes in Dictyostelium (growth in suspension culture, capping of Con A receptors, and development to fruiting bodies) and does not inhibit growth on plates, which does not require myosin II. As expected, macropinocytosis (myosin I-dependent), contractile vacuole activity (myosin V-dependent), and phagocytosis (myosin VII-dependent), none of which requires myosin II, are not inhibited by blebbistatin in myosin II-null cells, but, unexpectedly, blebbistatin does inhibit macropinocytosis and phagocytosis by cells expressing myosin II. Expression of catalytically inactive myosin II in myosin II-null cells also inhibits macropinocytosis and phagocytosis. Both blebbistatin-inhibited myosin II and catalytically inactive myosin II form cytoplasmic aggregates, which may be why they inhibit myosin II-independent processes, but neither affects the distribution of actin filaments in vegetative cells or actin and myosin distribution in dividing or polarized cells. Blebbistatin also inhibits cell streaming and plaque expansion in myosin II-null cells. Our results are consistent with myosin II being the only Dictyostelium myosin that is inhibited by blebbistatin but also show that blebbistatin-inactivated myosin II inhibits some myosin II-independent processes and that blebbistatin inhibits other activities in the absence of myosin II. PMID:15671182

  19. Reversible sequential transfer of two electrons at the same potential in bis(1,3,5-triketonato)dicopper(II) complexes and their diamine Schiff bases. Effect of Na/sup +/ and similar ions on the cyclic voltammetry

    SciTech Connect

    Lintvedt, R.L.; Kramer, L.S.

    1983-03-02

    The cyclic voltammetry of four binuclear Cu(II) 1,3,5-triketonates and their diamine Schiff-base derivatives has been investigated in DMF with (C/sub 2/H/sub 5/)/sub 4/NClO/sub 4/ as the supporting electrolyte. Addition of simple cations such as Na/sup +/ to these solutions has a profound effect on the reduction potentials of the Cu(II) ions and on the stability of the reduced product. In the presence of a sufficient concentration of Na/sup +/ ions, the complexes exhibit one CV wave due to the coppers with peak separations of 42-44 mV and cathodic half-peak widths of 42-44 mV also. These results may be obtaned with no instrumental iR compensation, providing a high concentration of the supporting electrolyte is present. The process is reversible with use of the criteria of scan rate dependence of the cathodic peak current and width and the equivalence of the cathodic and anodic peak heights. Controlled-potential electrolysis results prove that the process involves the transfer of two electrons. All of the experimental facts may be explained by the reversible, sequential transfer of two electrons at the same potential. Although the two Cu(II) ions in the diamine Schiff bases are in much different coordination environments within the same molecule, they give rise to the same CV wave shapes as the triketonates; i,e., ..delta..E/sub p/ and E/sub pc/ - E/sub p///sub 2/ both are very nearly 42 mV. Thus, they also undergo two-electron transfer at the same potential. The only significant difference between the simpler binuclear Cu(II) triketonates and the diamine Schiff-base derivatives is that E/sub 1///sub 2/ values for the Schiff bases are about 0.1V more negative than for their triketonate analogues.

  20. MPS II drift chamber system

    SciTech Connect

    Platner, E.D.

    1982-01-01

    The MPS II detectors are narrow drift space chambers designed for high position resolution in a magnetic field and in a very high particle flux environment. Central to this implementation was the development of 3 multi-channel custom IC's and one multi-channel hybrid. The system is deadtimeless and requires no corrections on an anode-to-anode basis. Operational experience and relevance to ISABELLE detectors is discussed.

  1. Light echoes - Type II supernovae

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.

    1987-01-01

    Type II supernovae (SNs) light curves show a remarkable range of shapes. Data have been collected for the 12 Type II SNs that have light curve information for more than four months past maximum. Contrary to previous reports, it is found that (1) the decay rate after 100 days past maximum varies by almost an order of magnitude and (2) the light curve shapes are not bimodally distributed, but actually form a continuum. In addition, it is found that the extinctions to the SNs are related to the light curve shapes. This implies that the absorbing dust is local to the SNs. The dust is likely to be part of a circumstellar shell emitted by the SN progenitor that Dwek (1983) has used to explain infrared echoes. The optical depth of the shell can get quite large. In such cases, it is found that the photons scattered and delayed by reflection off dust grains will dominate the light curve several months after peak brightness. This 'light echo' offers a straightforward explanation of the diversity of Type II SN light curves.

  2. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. )

    1993-01-10

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  3. PEP-II Operations Report

    SciTech Connect

    Zisman, Michael S.

    2000-11-01

    PEP-II is a two-ring asymmetric B factory operating at the Upsilon(4S) resonance. It was constructed by a SLAC-LBNL-LLNL collaboration. The collider comprises two rings, a High-Energy Ring (HER) storing 9 GeV electrons, and a Low-Energy Ring (LER) storing 3.1 GeV positrons. Commissioning of the HER began in mid-1997 and commissioning of the LER began in mid-1998. First evidence for collisions was obtained on July 23, 1998. The BaBar detector was installed in early 1999, and commissioning with the detector commenced in May 1999. By September 1999, PEP-II had reached a peak luminosity of 1.35 x 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. In the present run, which began in October 1999, the peak luminosity has reached 3.1 x 10{sup 33} cm{sup {minus}2} s{sup {minus}1} and the integrated luminosity delivered is 25 fb{sup {minus}1}. At present, PEP-II is the world's highest luminosity collider. In this paper we describe the startup experience and summarize the operational experience during fiscal year 2000 (from October 1999 through September 2000). Plan s for luminosity upgrades are briefly described.

  4. Antimutagenicity and induction of anticarcinogenic phase II enzymes by basidiomycetes.

    PubMed

    Shon, Y H; Nam, K S

    2001-09-01

    Extracts from Phellinus linteus, Phellinus igniarius, and Agrocybe cylindracea have been tested for their antimutagenic properties against direct-acting mutagens [4-nitro-o-phenylenediamine (NPD) and sodium azide (NaN(3))] and indirect-acting mutagens [2-aminofluorene (2-AF) and benzo[a]pyrene (B[a]P)], using the Salmonella typhimurium tester strains TA 98 and TA 100. In addition, the chemopreventive potentials of these extracts to induce NAD(P)H:quinone oxidoreductase (QR) and glutathione S-transferase (GST) activities and glutathione (GSH) level extracts from the filtrate of the cultured broth of P. linteus, polysaccharide extracts from the cultured broth (PI I) and mycelia (PI II) and water extract of fruiting bodies (PI II) of P. igniarius, and polysaccharide extracts from the cultured broth (AC I) and mycelia (AC II) of A. cylindracea showed inhibitory effects on the mutagenic activities induced by the direct-acting mutagens, NPD and NaN(3), and the indirect-acting mutagens, 2-AF and B[a]P. QR was induced with PI I, PI II, AC I, and AC II, and GST activity was induced with PL I, PL II, PI I, PI II, PI III and AC I in murine Hepa1c1c7 cell culture. In addition, PL I, PL II, PI I, PI II, PI III and AC II increased glutathione level. These results suggest that P. linteus, P. igniarius, and A. cylindracea have antimutagenic activities and may play a role in the prevention of cancer by inducing QR and GST activities and increasing GSH level. PMID:11483385

  5. Argus II retinal prosthesis system: An update.

    PubMed

    Rachitskaya, Aleksandra V; Yuan, Alex

    2016-09-01

    This review focuses on a description of the Argus II retinal prosthesis system (Argus II; Second Sight Medical Products, Sylmar, CA) that was approved for humanitarian use by the FDA in 2013 in patients with retinitis pigmentosa with bare or no light perception vision. The article describes the components of Argus II, the studies on the implant, and future directions. PMID:26855177

  6. Spectroscopic and mycological studies of Co(II), Ni(II) and Cu(II) complexes with 4-aminoantipyrine derivative

    NASA Astrophysics Data System (ADS)

    Sharma, Amit Kumar; Chandra, Sulekh

    2011-10-01

    Complexes of the type [M(L)X 2], where M = Co(II), Ni(II) and Cu(II), have been synthesized with novel NO-donor Schiff's base ligand, 1,4-diformylpiperazine bis(4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) which is obtained by the acid catalyzed condensation of 1,4-diformylpiperazine with 4-aminoantipyrine. The elemental analyses, molar conductance measurements, magnetic susceptibility measurements, IR, UV, NMR, mass and EPR studies of the compounds led to the conclusion that the ligand acts as tetradentate chelate. The Schiff's base ligand forms hexacoordinated complexes having octahedral geometry for Ni(II) and tetragonal geometry for Co(II) and Cu(II) complexes. The mycological studies of the compounds were examined against the several opportunistic pathogens, i.e., Alternaria brassicae, Aspergillus niger and Fusarium oxysporum. The Cu(II) complexes were found to have most fungicidal behavior.

  7. 40 CFR Table II-1 to Subpart II of... - Emission Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table...

  8. 40 CFR Table II-1 to Subpart II of... - Emission Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table...

  9. Synthesis, spectral characterization and biological evaluation of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with thiosemicarbazone ending by pyrazole and pyridyl rings

    NASA Astrophysics Data System (ADS)

    Yousef, T. A.; Abu El-Reash, G. M.; Al-Jahdali, M.; El-Rakhawy, El-Bastawesy R.

    2014-08-01

    Here we present the synthesis of the new Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with chelating ligand (Z)-(2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene) hydrazinyl)(pyridin-2-ylamino)methanethiol. All the complexes were characterized by elemental analysis, IR, 1H NMR, UV-vis, magnetic susceptibility measurements and EPR spectral studies. IR spectra of complexes showed that the ligand behaves as NN neutral bidentate, NSN mononegative tridentate and NSNN mononegative tetradentate. The electronic spectra and the magnetic measurements suggested the octahedral geometry for all complexes as well as the EPR confirmed the tetragonal distorted octahedral for Cu(II) complex. Cd(II) complex showed the highest inhibitory antioxidant activity either using ABTS method. The SOD-like activity exhibited those Cd(II) and Zn(II) complexes have strong antioxidative properties. We tested the synthesized compounds for antitumor activity and showed that the ability to kill liver (HePG2) and breast (MCF-7) cancer cells definitely.

  10. Zeeman effect of As II.

    NASA Technical Reports Server (NTRS)

    Li, H.; Andrew, K. L.

    1972-01-01

    Spectrograms of As electrodeless-discharge tubes operated in a field of 24,025 G have given Zeeman patterns for 232 As II spectral lines from 2361 to 10,556 A and yielded 80 Lande g factors, of which more than half are new. There is agreement between these and the g values calculated by least-squares fitting for single configurations or for multiconfigurations, where configuration interaction is noticeable. All of the measured g values as well as the energy levels are used in the fitting process.

  11. Commissioning of NSLS-II

    SciTech Connect

    Willeke, F.

    2015-05-03

    NSLS-II, the new 3rd generation light source at BNL was designed for a brightness of 1022 photons s-1mm-2mrad-2 (0.1%BW)-1. It was constructed between 2009 and 2014. The storage ring was commissioned in April 2014 which was followed by insertion device and beamline commissioning in the fall of 2014. All ambitious design parameters of the facility have already been achieved except for commissioning the full beam intensity of 500mA which requires more RF installation. This paper reports on the results of commissioning.

  12. Shuttle II - The next generation

    NASA Astrophysics Data System (ADS)

    Eldred, C. H.

    1986-01-01

    A comparative evaluation is conducted for next-generation Space Shuttle-type system configurations, in light of mission and design goals, performance and operational requirements, and technology development needs and opportunities. Cargo vehicle options presently entertained are an unmanned Shuttle Derivative Vehicle and a Heavy Lift Launch Vehicle. Two high priority manned vehicle options are small (35,000-lb payload) and large (150,000-lb payload) fully reusable vehicles. Attention is given to single stage vs. two-stage 'Shuttle II' system performance and economic projections.

  13. Hydrothermal synthesis, structure, and characterization of a mixed-valent iron(II/III) phosphate, NaFe{sub 3.67}(PO{sub 4}){sub 3}: A new variation of the alluaudite structure type

    SciTech Connect

    Korzenski, M.B.; Schimek, G.L.; Kolis, J.W.; Long, G.J.

    1998-08-01

    A mixed-valent Fe(II/III) phosphate, NaFe{sub 3.67}(PO{sub 4}){sub 3}, has been synthesized by high-temperature/high-pressure hydrothermal methods and characterized by single-crystal X-ray diffraction, EDAX, magnetic susceptibility, Moessbauer, infrared, and diffuse reflectance spectroscopies, DTA, and bond valence sum calculations. The compound crystallizes in the monoclinic space group C2/c (No. 15) with a = 11.881(4) {angstrom}, b = 12.564(3) {angstrom}, c = 6.522(2) {angstrom}, {beta} = 115.09(2){degree}, V = 881.7(5) {angstrom}{sup 3}, and Z = 4 with R/R{sub w} = 0.029/0.033. It exhibits a three-dimensional channel-like structure with an open framework that is similar to the naturally occurring iron-containing mineral alluaudite, NaFe{sub 3}(PO{sub 4}){sub 3}. In alluaudite there are two distinct channels, one which contains the sodium cations and the second which remains empty. In the title phase, this second channel is partially occupied by a square-planar iron atom. The Moessbauer spectral parameters are consistent with the structure and indicate that the fully occupied iron sites are octahedral Fe(II) and the square-planar iron is Fe(III). Structural comparisons to a number of phosphates and arsenates that also possess the alluaudite-type structure, including NaCu{sub 4}(AsO{sub 4}){sub 3} and NaMn{sub 4}(AsO{sub 4}){sub 3} are discussed.

  14. Mass spectrometry and potentiometry studies of Pb(II)-, Cd(II)- and Zn(II)-cystine complexes.

    PubMed

    Furia, Emilia; Aiello, Donatella; Di Donna, Leonardo; Mazzotti, Fabio; Tagarelli, Antonio; Thangavel, Hariprasad; Napoli, Anna; Sindona, Giovanni

    2014-01-21

    Cd(II)-, Pb(II)- and Zn(II)-cystine complexes were investigated by potentiometric and different mass spectrometric (MS) methodologies. Laser desorption mass spectrometry has provided both the composition and structure of metal-cystine complexes according to the speciation models proposed on the basis of the potentiometric data. Detection of neutral complexes was achieved by protonation or electrochemical reduction during mass spectrometric experiments. The redox activity of metal-cystine complexes was confirmed by laser desorption and charge transfer matrix assisted laser assisted MS experiments, which allowed us to observe the formation of complexes with a reduction of cystine. The stoichiometry of Cd(II)-, Pb(II)- and Zn(II)-cystine complexes was defined by observing the isotopic pattern of the investigated compound. The results suggest that interaction occurs through the carboxylate group of the ligand.

  15. Spectral studies on cobalt(II), nickel(II) and copper(II) complexes of naphthaldehyde substituted aroylhydrazones.

    PubMed

    Singh, Pramod Kumar; Kumar, Deo Nandan

    2006-07-01

    A series of new coordination complexes of cobalt(II), nickel(II) and copper(II) with two new aroylhydrazones, 2-hydroxy-1-naphthaldehyde isonicotinoylhydrazone (H(2)L(1)) and 2-hydroxy-1-naphthaldehyde-2-thenoyl-hydrazone (H(2)L(2)) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibility measurements, (1)H NMR spectroscopy, IR spectroscopy, electronic spectroscopy, EPR spectroscopy and thermal analysis. IR spectra suggests ligands acts as a tridentate dibasic donor coordinating through the deprotonated naphtholic oxygen atom, azomethine nitrogen atom and enolic oxygen atom. EPR and ligand field spectra suggests octahedral geometry for Co(II) and Ni(II) complexes and a square planar geometry for Cu(II) complexes. PMID:16529995

  16. Spectral studies on cobalt(II), nickel(II) and copper(II) complexes of naphthaldehyde substituted aroylhydrazones

    NASA Astrophysics Data System (ADS)

    Singh, Pramod Kumar; Kumar, Deo Nandan

    2006-07-01

    A series of new coordination complexes of cobalt(II), nickel(II) and copper(II) with two new aroylhydrazones, 2-hydroxy-1-naphthaldehyde isonicotinoylhydrazone (H 2L 1) and 2-hydroxy-1-naphthaldehyde-2-thenoyl-hydrazone (H 2L 2) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibility measurements, 1H NMR spectroscopy, IR spectroscopy, electronic spectroscopy, EPR spectroscopy and thermal analysis. IR spectra suggests ligands acts as a tridentate dibasic donor coordinating through the deprotonated naphtholic oxygen atom, azomethine nitrogen atom and enolic oxygen atom. EPR and ligand field spectra suggests octahedral geometry for Co(II) and Ni(II) complexes and a square planar geometry for Cu(II) complexes.

  17. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. . Dept. of Chemical and Nuclear Engineering)

    1992-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz 11 space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safely assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the US with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  18. The SRC-II process

    NASA Astrophysics Data System (ADS)

    Schmid, B. K.; Jackson, D. M.

    1981-03-01

    The Solvent Refined Coal (SRC-II) process which produces low-sulfur distillate fuel oil from coal is discussed. The process dissolves coal in a process-derived solvent at elevated temperature and pressure in the presence of hydrogen, separates the undissolved mineral residue, then recovers the original solvent by vacuum distillation. The distillate fuel oil produced is for use largely as a nonpolluting fuel for generating electrical power and steam and is expected to be competitive with petroleum fuels during the 1980s. During this period, the SRC-II fuel oil is expected to be attractive compared with combustion of coal with flue gas desulfurization in U.S. East Coast oil-burning power plants, as well as in small and medium-sized industrial boilers. The substantial quantities of methane, light hydrocarbons and naphtha produced by the process have value as feedstocks for preparation of pipeline gas, ethylene and high-octane unleaded gasoline, and can replace petroleum fractions in many applications. The liquid and gas products from a future large-scale plant, such as the 6000 t/day plant planned for Morgantown, West Virginia, are expected to have an overall selling price of $4.25 to $4.75/GJ.

  19. BNL ATF II beamlines design

    SciTech Connect

    Fedurin, M.; Jing, Y.; Stratakis, D.; Swinson, C.

    2015-05-03

    The Brookhaven National Laboratory. Accelerator Test Facility (BNL ATF) is currently undergoing a major upgrade (ATF-II). Together with a new location and much improved facilities, the ATF will see an upgrade in its major capabilities: electron beam energy and quality and CO2 laser power. The electron beam energy will be increased in stages, first to 100-150 MeV followed by a further increase to 500 MeV. Combined with the planned increase in CO2 laser power (from 1-100 TW), the ATF-II will be a powerful tool for Advanced Accelerator research. A high-brightness electron beam, produced by a photocathode gun, will be accelerated and optionally delivered to multiple beamlines. Besides the energy range (up to a possible 500 MeV in the final stage) the electron beam can be tailored to each experiment with options such as: small transverse beam size (<10 um), short bunch length (<100 fsec) and, combined short and small bunch options. This report gives a detailed overview of the ATFII capabilities and beamlines configuration.

  20. THE SPECTRUM OF Fe II

    SciTech Connect

    Nave, Gillian; Johansson, Sveneric

    2013-01-15

    The spectrum of singly ionized iron (Fe II) has been recorded using high-resolution Fourier transform (FT) and grating spectroscopy over the wavelength range 900 A to 5.5 {mu}m. The spectra were observed in high-current continuous and pulsed hollow cathode discharges using FT spectrometers at the Kitt Peak National Observatory, Tucson, AZ and Imperial College, London and with the 10.7 m Normal Incidence Spectrograph at the National Institute of Standards and Technology. Roughly 12,900 lines were classified using 1027 energy levels of Fe II that were optimized to measured wavenumbers. The wavenumber uncertainties of lines in the FT spectra range from 10{sup -4} cm{sup -1} for strong lines around 4 {mu}m to 0.05 cm{sup -1} for weaker lines around 1500 A. The wavelength uncertainty of lines in the grating spectra is 0.005 A. The ionization energy of (130,655.4 {+-} 0.4) cm{sup -1} was estimated from the 3d{sup 6}({sup 5}D)5g and 3d{sup 6}({sup 5}D)6h levels.

  1. Synthesis, spectroscopic characterization, thermal analysis and electrical conductivity studies of Mg(II), Ca(II), Sr(II) and Ba(II) vitamin B2 complexes

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Moussa, Mohamed A. A.; Mohamed, Soha F.

    2011-05-01

    Riboflavin (RF) complexes of Mg(II), Ca(II), Sr(II) and Ba(II) were successfully synthesized. Structures of metal complexes obtained were confirmed and characterized by elemental analysis, molar conductance, and infrared spectra. DC electrical conductivity measurements indicated that the alkaline earth metal (II) complexes of RF ligand are non-electrolytes. Elemental analysis of chelates suggest that the metal(II) ligand ratio is 1:2 with structure formula as [M(RF) 2( X) 2]· nH 2O. Infrared assignments clearly show that RF ligand coordinated as a bidentate feature through azomethine nitrogen of pyrazine ring and C dbnd O of pyrimidine-2,4-dione. Thermal analyses of Mg(II), Ca(II), Sr(II) and Ba(II) complexes were investigated using (TG/DSC) under atmospheric nitrogen between 30 and 800 °C. The surface morphology of the complexes was studied by SEM. The electrical conductivities of RF and its metal complexes were also measured with DC electrical conductivity in the temperature range from room to 483 K.

  2. Use of anodic stripping voltammetry to determine zinc(II), lead(II), and copper(II) in foods

    SciTech Connect

    Maksimkina, L.M.; Gus'kova, V.P.

    1988-01-20

    The existing standard procedure for the polarographic determination of Zn, Pb, and Cu, based on the cathodic polarization of a dropping mercury electrode, is laborious and time-consuming and allows one to determine the above-mentioned trace elements only when they are separated beforehand. We consider the possibility of using anodic stripping voltammetry with a mercury film electrode for the simultaneous determination of Zn(II), Pb(II), and Cu(II) in foods.

  3. Quiet High Speed Fan II (QHSF II): Final Report

    NASA Technical Reports Server (NTRS)

    Kontos, Karen; Weir, Don; Ross, Dave

    2012-01-01

    This report details the aerodynamic, mechanical, structural design and fabrication of a Honey Engines Quiet High Speed Fan II (lower hub/tip ratio and higher specific flow than the Baseline I fan). This fan/nacelle system incorporates features such as advanced forward sweep and an advanced integrated fan/fan exit guide vane design that provides for the following characteristics: (1) Reduced noise at supersonic tip speeds, in comparison to current state-of-the-art fan technology; (2) Improved aeroelastic stability within the anticipated operating envelope; and (3) Aerodynamic performance consistent with current state-of-the-art fan technology. This fan was fabricated by Honeywell and tested in the NASA Glenn 9- by 15-Ft Low Speed Wind Tunnel for aerodynamic, aeromechanical, and acoustic performance.

  4. EDTA functionalized silica for removal of Cu(II), Zn(II) and Ni(II) from aqueous solution.

    PubMed

    Kumar, R; Barakat, M A; Daza, Y A; Woodcock, H L; Kuhn, J N

    2013-10-15

    Ethylenediaminetetraacetic acid (EDTA) functionalized silica adsorbent has been synthesized using (3-aminopropyl) triethoxylsilane (APTES) as a bridging link between silanol groups (SiOH) of silica and carboxylic group of EDTA. Fourier transform infrared spectroscopy (FTIR) and Temperature-programmed oxidation (TPO) analysis confirmed the grafting of EDTA onto the silica. The synthesized EDTA-silica was investigated as an adsorbent for removal of Cu(II), Zn(II) and Ni(II) from aqueous solution. The effect of solution pH, initial solution concentration, and contact time were studied. The removal of metal ions increased with the increase in solution pH, contact time and concentration. The maximum equilibrium time was found to be 45min for all three metal ions. Kinetics studies revealed that the adsorption of Cu(II), Zn(II) and Ni(II) onto EDTA-silica followed the pseudo-second order kinetics and film diffusion and intra-particle diffusion mechanism were involved. Adsorption equilibrium data were well fitted to Langmuir isotherm model and maximum monolayer adsorption capacity for Cu(II), Zn(II) and Ni(II) was 79.36, 74.07 and 67.56mg g(-1), respectively. Thermodynamic results reveal that the removal of metals onto EDTA-silica was endothermic and spontaneous in nature.

  5. Desensitisation of native and recombinant human urotensin-II receptors.

    PubMed

    Batuwangala, Madura S; Calo, Girolamo; Guerrini, Remo; Ng, Leong L; McDonald, John; Lambert, David G

    2009-11-01

    Human urotensin-II (U-II) is an 11-amino-acid cyclic peptide that activates a G(q)-coupled receptor named UT. Little is known about the desensitisation profile of this receptor as peptide binding is essentially irreversible. In the present study, we have examined the effects of U-II and carbachol on Ca(2+) signalling in SJCRH30 rhabdomyosarcoma (receptor density, B(max) approximately 0.1 pmol/mg protein) and human embroynic kidney (HEK)(hUT) (B(max) approximately 1.4 pmol/mg protein) cells expressing native and recombinant UT, respectively. In SJCRH30, HEK(hUT) and human peripheral blood mononuclear cells induced to express native UT by treatment with 2 microg/ml lipopolysaccharide (LPS), we have measured the effects of U-II treatment on UT mRNA. In SJCRH30 cells, primary stimulation with carbachol (250 microM) did not affect a secondary challenge with U-II (1 microM) and primary challenge with U-II did not affect a secondary challenge with carbachol. In contrast, in HEK(hUT) cells, primary stimulation with carbachol (250 microM) reduced a secondary challenge to U-II (1 microM) by 84% and primary challenge with U-II reduced a secondary challenge to carbachol by 76%. Pre-treatment of SJCRH30 cells with U-II reduced UT mRNA after 6 h and this returned to basal after 24 h. In recombinant HEK(hUT) cells, UT mRNA expression increased following a 6 h treatment with 1 microM U-II. U-II treatment of naïve un-stimulated peripheral blood mononuclear cells was without effect. However, when UT expression is up-regulated following 15 h of LPS treatment, a 6 h U-II challenge reduced UT mRNA by 66%. In summary, we report differences in the desensitisation profiles of native and recombinant U-II receptors. Design and interpretation of functional experiments are hampered by irreversibility of U-II binding.

  6. Solid phase extraction of Cu(II), Ni(II), Pb(II), Cd(II) and Mn(II) ions with 1-(2-thiazolylazo)-2-naphthol loaded Amberlite XAD-1180.

    PubMed

    Tokalioğlu, Serife; Yilmaz, Vedat; Kartal, Senol

    2009-05-01

    A new method for separation and preconcentration of trace amounts of Cu(II), Ni(II), Pb(II), Cd(II) and Mn(II) ions in various matrices was proposed. The method is based on the adsorption and chelation of the metal ions on a column containing Amberlite XAD-1180 resin impregnated with 1-(2-thiazolylazo)-2-naphthol (TAN) reagent prior to their determination by flame atomic absorption spectrometry (FAAS). The effect of pH, type, concentration and volume of eluent, sample volume, flow rates of sample and elution solutions, and interfering ions have been investigated. The optimum pH for simultaneous retention of all the metal ions was 9. Eluent for quantitative elution was 20 ml of 2 mol l(-1) HNO(3). The optimum sample and eluent flow rates were found as 4 ml min(-1), and also sample volume was 500 ml, except for Mn (87% recovery). The sorption capacity of the resin was found to be 0.77, 0.41, 0.57, and 0.30 mg g(-1) for Cu(II), Ni(II), Cd(II), and Mn(II), respectively. The preconcentration factor of the method was 200 for Cu(II), 150 for Pb(II), 100 for Cd(II) and Ni(II), and 50 for Mn(II). The recovery values for all of the metal ions were > or = 95% and relative standard deviations (RSDs) were < or = 5.1%. The detection limit values were in the range of 0.03 and 1.19 microg l(-1). The accuracy of the method was confirmed by analysing the certified reference materials (TMDA 54.4 fortified lake water and GBW 07605 tea samples) and the recovery studies. This procedure was applied to the determination of Cu(II), Ni(II), Pb(II), Cd(II) and Mn(II) in waste water and lake water samples.

  7. Double quantum coherence electron spin resonance on coupled Cu(II)-Cu(II) electron spins

    NASA Astrophysics Data System (ADS)

    Becker, James S.; Saxena, Sunil

    2005-10-01

    We demonstrate for the first time the ability to generate double quantum coherences (DQCs) for the case of Cu(II). We show that small splittings (˜7 MHz) from the Cu(II)-Cu(II) electron-electron magnetic dipolar interaction can be reliably resolved even though the inhomogeneously broadened Cu(II) linewidth is ˜2 GHz. A Cu(II)-Cu(II) distance of 2.0 nm was measured on a model peptide system, thus, demonstrating that distances on the nanometer scale may be measured using DQC electron spin resonance (ESR).

  8. Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor

    PubMed Central

    Alevizopoulos, Konstantinos; Dimas, Konstantinos; Papadopoulou, Natalia; Schmidt, Eva-Maria; Tsapara, Anna; Alkahtani, Saad; Honisch, Sabina; Prousis, Kyriakos C.; Alarifi, Saud; Calogeropoulou, Theodora

    2016-01-01

    Sodium potassium pump (Na+/K+ ATPase) is a validated pharmacological target for the treatment of various cardiac conditions. Recent published data with Na+/K+ ATPase inhibitors suggest a potent anti-cancer action of these agents in multiple indications. In the present study, we focus on istaroxime, a Na+/K+ ATPase inhibitor that has shown favorable safety and efficacy properties in cardiac phase II clinical trials. Our experiments in 22 cancer cell lines and in prostate tumors in vivo proved the strong anti-cancer action of this compound. Istaroxime induced apoptosis, affected the key proliferative and apoptotic mediators c-Myc and caspase-3 and modified actin cystoskeleton dynamics and RhoA activity in prostate cancer cells. Interestingly, istaroxime was capable of binding to mAR, a membrane receptor mediating rapid, non-genomic actions of steroids in prostate and other cells. These results support a multi-level action of Na+/K+ ATPase inhibitors in cancer cells and collectively validate istaroxime as a strong re-purposing candidate for further cancer drug development. PMID:27027435

  9. Start II, red ink, and Boris Yeltsin

    SciTech Connect

    Arbatov, A.

    1993-04-01

    Apart from the vulnerability implied by the START II treaty, it will bear the burden of the general political opposition to the Yeltsin administration. START II will be seen as part of an overall Yeltsin-Andrei Kozyrev foreign policy that is under fire for selling out Russian national interests in Yugoslavia, the Persian Gulf, and elsewhere. This article discusses public opinion concerning START II, the cost of its implementation, and the general purpose of the treaty.

  10. Sample Exchange Evaluation (SEE) Report - Phase II

    SciTech Connect

    Winters, W.I.

    1994-09-28

    This report describes the results from Phase II of the Sample Exchange Evaluation (SEE) Program, a joint effort to compare analytical laboratory performance on samples from the Hanford Site`s high-level waste tanks. In Phase II, the program has been expanded to include inorganic constituents in addition to radionuclides. Results from Phase II that exceeded 20% relative percent difference criteria are identified.

  11. AGEX II: Technical quarterly, Volume 2

    SciTech Connect

    Ekdahl, C.

    1995-03-01

    The AGEX II Technical Quarterly publishes short technical contributions on above ground experiments that use pulsed power and laser drivers. The Quarterly is intended to provide rapid exposure of timely technical ideas and results as well as a means for documenting AGEX II progress and scientific quality for the AGEX II community. Suitable topics include experimental results, diagnostic apparatus, theoretical design, and scaling, among others.

  12. Telemetry Tests Of The Advanced Receiver II

    NASA Technical Reports Server (NTRS)

    Hinedi, Sami M.; Bevan, Roland P.; Marina, Miguel

    1993-01-01

    Report describes telemetry tests of Advanced Receiver II (ARX-II): digital radio receiving subsystem operating on intermediate-frequency output of another receiving subsystem called "multimission receiver" (MMR), detecting carrier, subcarrier, and data-symbol signals transmitted by spacecraft, and extracts Doppler information from signals. Analysis of data shows performance of MMR/ARX-II system comparable and sometimes superior to performances of Blk-III/BPA and Blk-III/SDA/SSA systems.

  13. ExodusII Finite Element Data Model

    SciTech Connect

    2005-05-14

    EXODUS II is a model developed to store and retrieve data for finite element analyses. It is used for preprocessing (problem definition), postprocessing (results visualization), as well as code to code data transfer. An EXODUS II data file is a random access, machine independent, binary file that is written and read via C, C++, or Fortran library routines which comprise the Application Programming Interface. (exodus II is based on netcdf)

  14. SAGE II aerosol correlative observations - Profile measurements

    NASA Technical Reports Server (NTRS)

    Osborn, M. T.; Rosen, J. M.; Mccormick, M. P.; Wang, Pi-Huan; Livinfston, J. M.

    1989-01-01

    Profiles of the aerosol extinction measurements from the Stratospheric Aerosol and Gas Experiment (SAGE) II are compared with profiles from five correlative experiments between November 1984 and July 1986. The correlative profiles were derived from six-channel dustsonde measurements and two-wavelength lidar backscatter data. The correlation between the dustsonde- and lidar-derived measurements and the SAGE II data is good, validating the SAGE II lower stratospheric aerosol extinction measurements.

  15. Probing outflows in z = 1 ∼ 2 galaxies through Fe II/Fe II* multiplets

    SciTech Connect

    Tang, Yuping; Giavalisco, Mauro; Guo, Yicheng

    2014-10-01

    We report on a study of the 2300-2600 Å Fe II/Fe II* multiplets in the rest-UV spectra of star-forming galaxies at 1.0 < z < 2.6 as probes of galactic-scale outflows. We extracted a mass-limited sample of 97 galaxies at z ∼ 1.0-2.6 from ultra-deep spectra obtained during the GMASS spectroscopic survey in the GOODS South field with the Very Large Telescope and FORS2. We obtain robust measures of the rest equivalent width of the Fe II absorption lines down to a limit of W{sub r} > 1.5 Å and of the Fe II* emission lines to W{sub r} > 0.5 Å. Whenever we can measure the systemic redshift of the galaxies from the [O II] emission line, we find that both the Fe II and Mg II absorption lines are blueshifted, indicating that both species trace gaseous outflows. We also find, however, that the Fe II gas has generally lower outflow velocity relative to that of Mg II. We investigate the variation of Fe II line profiles as a function of the radiative transfer properties of the lines, and find that transitions with higher oscillator strengths are more blueshifted in terms of both line centroids and line wings. We discuss the possibility that Fe II lines are suppressed by stellar absorptions. The lower velocities of the Fe II lines relative to the Mg II doublet, as well as the absence of spatially extended Fe II* emission in two-dimensional stacked spectra, suggest that most clouds responsible for Fe II absorption lie close (3 ∼ 4 kpc) to the disks of galaxies. We show that the Fe II/Fe II* multiplets offer unique probes of the kinematic structure of galactic outflows.

  16. Neurosurgical notes: World War II.

    PubMed

    Pool, J L

    2000-03-01

    This concerns my activities as a neurosurgeon in the European Theater of Operations and the North African, Tunisian campaign, during World War II. Action during the Battle of the Bulge came later. Our mobile tent hospital, the 9th Evacuation Hospital, was similar to that depicted in the television show M*A*S*H. To lend flavor to these comments, I have referred to medical and surgical matters in other units as well as our own, mentioned global aspects of the war, and included vignettes of life off-duty. The story begins after induction into the Army Medical Corps as a volunteer in July 1942 and ends with honorable discharge in April 1946. PMID:10719869

  17. EPACT II: project and methods.

    PubMed

    Juillerat, Pascal; Froehlich, Florian; Felley, Christian; Pittet, Valérie; Mottet, Christian; Gonvers, Jean-Jacques; Michetti, Pierre; Vader, John-Paul

    2007-01-01

    Building on the first European Panel on the Appropriateness of Crohn's Disease Treatment (EPACT I) which was held in Lausanne at the beginning of March 2004, a new panel will be convened in Switzerland (EPACT II, November to December 2007) to update this work. A combined evidence- and panel-based method (RAND) will be applied to assess the appropriateness of therapy for Crohn's disease (CD). In preparation for the meeting of experts, reviews of evidence-based literature were prepared for major clinical presentations of CD. During the meeting, an international multidis- ciplinary panel that includes gastroenterologists, surgeons and general practitioners weigh the strength of evidence and apply their clinical experience when assessing the appropriateness of therapy for 569 specific indications (clinical scenarios). This chapter describes in detail the process of updating the literature review and the systematic approach of the RAND Appropriateness Method used during the expert panel meeting. PMID:18239398

  18. Type II Transmembrane Serine Proteases*

    PubMed Central

    Bugge, Thomas H.; Antalis, Toni M.; Wu, Qingyu

    2009-01-01

    Analysis of genome and expressed sequence tag data bases at the turn of the millennium unveiled a new protease family named the type II transmembrane serine proteases (TTSPs) in a Journal of Biological Chemistry minireview (Hooper, J. D., Clements, J. A., Quigley, J. P., and Antalis, T. M. (2001) J. Biol. Chem. 276, 857–860). Since then, the number of known TTSPs has more than doubled, and more importantly, our understanding of the physiological functions of individual TTSPs and their contribution to human disease has greatly increased. Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field. PMID:19487698

  19. Optimization of simultaneous electrochemical determination of Cd(II), Pb(II), Cu(II) and Hg(II) at carbon nanotube-modified graphite electrodes.

    PubMed

    Pikna, L'ubomír; Heželová, Mária; Kováčová, Zuzana

    2015-01-01

    The health of the environment is worsening every day. Monitoring of potentially toxic elements and remediation of environmental pollution are necessary. Therefore, the research and development of simple, inexpensive, portable and effective sensors is important. Electrochemistry is a useful component of the field of environment monitoring. The present study focuses on evaluating and comparing three types of electrodes (PIGE, PIGE/MWCNT/HNO3 and PIGE/MWCNT/EDTA/HNO3) employed for the simultaneous electrochemical determination of four potentially toxic elements: Cd(II), Pb(II), Cu(II) and Hg(II). Cyclic voltammograms were measured in an acetate buffer. The LOD, LOQ, the standard and relative precisions of the method and a prediction intervals were calculated (according to the technical procedure DIN 32 645) for the three electrodes and for each measured element. The LOD for PIGE/CNT/HNO3 (the electrode with narrowest calculated prediction intervals) was 2.98 × 10(-7) mol L(-1) for Cd(II), 4.83 × 10(-7) mol L(-1) for Pb(II), 3.81 × 10(-7) mol L(-1) for Cu(II), 6.79 × 10(-7) mol L(-1) for Hg(II). One of the benefits of this study was the determination of the amount of Hg(II) in the mixture of other elements.

  20. SWAMI II technology transfer plan

    SciTech Connect

    Ward, C.R.; Peterson, K.D.; Harpring, L.J.; Immel, D.M.; Jones, J.D.; Mallet, W.R.

    1995-12-31

    Thousands of drums of radioactive/hazardous/mixed waste are currently stored at DOE sites throughout US; they are stored in warehouse facilities on an interim basis, pending final disposition. Recent emphasis on anticipated decommissioning of facilities indicates that many more drums of waste will be generated, requiring additional storage. Federal and state regulations dictate that hazardous waste covered by RCRA be inspected periodically for container degradation and to verify inventories. All known DOE waste storage facilities are currently inspected manually. A system to perform robotic inspection of waste drums is under development by the SRTC Robotics Group of WSRC; it is called the Stored Waste Autonomous Mobile Inspector (SWAMI). The first version, SWAMI I, was developed by the Savannah River Technology Center (SRTC) as a proof of principle system for autonomous inspection of drums in a warehouse. SWAMI I was based on the Transitions Research Corporation (TRC) HelpMate mobile robot. TRC modified the Helpmate to navigate in aisles of drums. SRTC added subsystems to SWAMI I to determine its position in open areas, read bar code labels on the drums up to three levels high, capture images of the drums and perform a radiation survey of the floor in the aisles. The radiation survey was based on SRTC patented technology first implemented on the Semi-Intelligent Mobile Observing Navigator (SIMON). The radiation survey is not essential for the inspection of drums, but is an option that can increase the utility and effectiveness of SWAMI in warehouses with radioactive and/or mixed waste. All the sensors on SWAMI I were fixed on the vehicle. From the success of SWAMI I, a second version, SWAMI II, was developed; it will be evaluated at Fernald and tested with two other mobile robots. Intent is to transfer the technology developed for SWAMI I and II to industry so that it can supply additional units for purchase for drum inspection.

  1. Phase II metabolism of benzene.

    PubMed Central

    Schrenk, D; Orzechowski, A; Schwarz, L R; Snyder, R; Burchell, B; Ingelman-Sundberg, M; Bock, K W

    1996-01-01

    The hepatic metabolism of benzene is thought to be a prerequisite for its bony marrow toxicity. However, the complete pattern of benzene metabolites formed in the liver and their role in bone marrow toxicity are not fully understood. Therefore, benzene metabolism was studied in isolated rodent hepatocytes. Rat hepatocytes released benzene-1,2-dihydrodiol, hydroquinone (HQ), catechol (CT), phenol (PH), trans-trans-muconic acid, and a number of phase II metabolites such as PH sulfate and PH glucuronide. Pretreatment of animals with 3-methylcholantrene (3-MC) markedly increased PH glucuronide formation while PH sulfate formation was decreased. Likewise, V79 cells transfected with the 3-MC-inducible rat UGT1.6 cDNA showed a considerable rate of PH and HQ glucuronidation. In addition to inducing glucuronidation of phenols, 3-MC treatment (reported to protect rats from the myelotoxicity of benzene) resulted in a decrease of hepatic CYP2E1. In contrast, pretreatment of rats with the CYP2E1-inducer isopropanol strongly enhanced benzene metabolism and the formation of phenolic metabolites. Mouse hepatocytes formed much higher amounts of HQ than rat hepatocytes and considerable amounts of 1,2,4-trihydroxybenzene (THB) sulfate and HQ sulfate. In conclusion, the protective effect of 3-MC in rats is probably due to a shift from the labile PH sulfate to the more stable PH glucuronide, and to a decrease in hepatic CYP2E1. The higher susceptibility of mice toward benzene may be related to the high rate of formation of the myelotoxic metabolite HQ and the semistable phase II metabolites HQ sulfate and THB sulfate. Images Figure 4. PMID:9118891

  2. Syntheses, crystal structures and spectroscopic properties of copper(II)-tetracyanometallate(II) complexes with nicotinamide and isonicotinamide ligands

    NASA Astrophysics Data System (ADS)

    Sayın, Elvan; Kürkçüoğlu, Güneş Süheyla; Yeşilel, Okan Zafer; Hökelek, Tuncer

    2015-09-01

    Four new one dimensional (1D) cyanide complexes, namely {[Cu(NH3)4(μ-na)][M‧(CN)4]}n and {[Cu(NH3)2(ina)2M‧(μ-CN)2(CN)2]}n (M‧(II) = Pd (1 and 3) or Pt (2 and 4), na:nicotinamide and ina:isonicotinamide) have been synthesized and characterized by elemental, spectral (FT-IR and Raman), and thermal (TG, DTG and DTA) analyses. The crystal structures of complexes 1-3 have been determined by single crystal X-ray diffraction technique. In complexes 1 and 2, na ligand is coordinated to the adjacent Cu(II) ions as a bridging ligand, giving rise to 1D linear cationic chain and the [M‧(CN)4]2- anionic complex acts as a counter ion. Complexes 3 and 4 are also 1D linear chain in which two cyanide ligands bridged neighboring M‧(II) and Cu(II) ions, while ina ligand is coordinated Cu(II) ion through nitrogen atom of pyridine ring. In the complexes, the Cu(II) ions adopt distorted octahedral geometries, while M‧(II) ions are four coordinated with four carbon atoms from cyanide ligands in square-planar geometries. The adjacent chains are further stacked through intermolecular hydrogen bond, Nsbnd Hṡṡṡπ, Csbnd H⋯M‧ and M‧⋯π interactions to form 3D supramolecular networks. Vibration assignments are given for all the observed bands. In addition, thermal stabilities of the compounds are also discussed.

  3. Accurate Ritz Wavelengths of Parity-forbidden [Co II] and [V II] Lines of Astrophysical Interest

    NASA Astrophysics Data System (ADS)

    Ruffoni, M. P.; Pickering, J. C.

    2013-08-01

    We report a comprehensive list of accurate Ritz wavelengths for parity-forbidden [Co II] and [V II] lines obtained from the analysis of energy levels measured in the laboratory with Fourier transform emission spectroscopy. Such lines, particularly those in the infrared, are in demand for the analysis of low-density astrophysical plasmas in and around objects such as planetary nebulae, star-forming regions, and active galactic nuclei. Transitions between all known metastable levels of Co II and V II are included in our analysis, producing wavelengths for 1477 [V II] lines and 782 [Co II] lines. Of these, 170 [V II] lines and 171 [Co II] lines arise from transitions with calculated transition probabilities greater than 1 × 10-2 s-1 and upper level excitations of less than 5 eV, and thus are likely to be observed in astrophysical spectra.

  4. ACCURATE RITZ WAVELENGTHS OF PARITY-FORBIDDEN [Co II] AND [V II] LINES OF ASTROPHYSICAL INTEREST

    SciTech Connect

    Ruffoni, M. P.; Pickering, J. C.

    2013-08-15

    We report a comprehensive list of accurate Ritz wavelengths for parity-forbidden [Co II] and [V II] lines obtained from the analysis of energy levels measured in the laboratory with Fourier transform emission spectroscopy. Such lines, particularly those in the infrared, are in demand for the analysis of low-density astrophysical plasmas in and around objects such as planetary nebulae, star-forming regions, and active galactic nuclei. Transitions between all known metastable levels of Co II and V II are included in our analysis, producing wavelengths for 1477 [V II] lines and 782 [Co II] lines. Of these, 170 [V II] lines and 171 [Co II] lines arise from transitions with calculated transition probabilities greater than 1 Multiplication-Sign 10{sup -2} s{sup -1} and upper level excitations of less than 5 eV, and thus are likely to be observed in astrophysical spectra.

  5. Kinetics of Formation of Cobalt(II)- and Nickel(II) Carbonic Anhydrase.

    ERIC Educational Resources Information Center

    McQuate, Robert S.; Reardon, John E.

    1978-01-01

    Discusses the kinetic behavior associated with the interaction of metal ions with apocarbonic anhydrase, focusing on the formation of two metallocarbonic anhydrase--the biochemically active Co(II) and the inactive Ni(II)derivatives. (GA)

  6. Molecular cloning, sequencing, and expression analysis of cDNA encoding metalloprotein II (MP II) induced by single and combined metals (Cu(II), Cd(II)) in polychaeta Perinereis aibuhitensis.

    PubMed

    Yang, Dazuo; Zhou, Yibing; Zhao, Huan; Zhou, Xiaoxiao; Sun, Na; Wang, Bin; Yuan, Xiutang

    2012-11-01

    We amplified and analyzed the complete cDNA of metalloprotein II (MP II) from the somatic muscle of the polychaete Perinereis aibuhitensis, the full length cDNA is 904 bp encoding 119 amino acids. The MP II cDNA sequence was subjected to BLAST searching in NCBI and was found to share high homology with hemerythrin of other worms. MP II expression of P. aibuhitensis exposed to single and combined metals (Cu(II), Cd(II)) was analyzed using real time-PCR. MP II mRNA expression increased at the start of Cu(II) exposure, then decreased and finally return to the normal level. Expression pattern of MP II under Cd(II) exposure was time- and dose-dependent. MP II expression induced by a combination of Cd(II) and Cu(II) was similar to that induced by Cd(II) alone.

  7. Cohesin regulates MHC class II genes through interactions with MHC class II insulators.

    PubMed

    Majumder, Parimal; Boss, Jeremy M

    2011-10-15

    Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains. The human MHC class II (MHC-II) locus contains 10 intergenic elements, termed MHC-II insulators, which bind the transcriptional insulator protein CCCTC-binding factor. MHC-II insulators interact with each other, forming a base architecture of discrete loops and potential regulatory domains. When MHC-II genes are expressed, their proximal promoter regulatory regions reorganize to the foci established by the interacting MHC-II insulators. MHC-II insulators also bind cohesin, but the functional role of cohesin in regulating this system is not known. In this article, we show that the binding of cohesin to MHC-II insulators occurred irrespective of MHC-II expression but was required for optimal expression of the HLA-DR and HLA-DQ genes. In a DNA-dependent manner, cohesin subunits interacted with CCCTC-binding factor and the MHC-II-specific transcription factors regulatory factor X and CIITA. Intriguingly, cohesin subunits were important for DNA looping interactions between the HLA-DRA promoter region and a 5' MHC-II insulator but were not required for interactions between the MHC-II insulators themselves. This latter observation introduces cohesin as a regulator of MHC-II expression by initiating or stabilizing MHC-II promoter regulatory element interactions with the MHC-II insulator elements, events that are required for maximal MHC-II transcription.

  8. Competitive Fe(II)-Zn(II) uptake on a synthetic montmorillonite.

    PubMed

    Soltermann, Daniela; Marques Fernandes, Maria; Baeyens, Bart; Miehé-Brendlé, Jocelyne; Dähn, Rainer

    2014-01-01

    The interaction of Fe(II) with clay minerals is of particular relevance in global geochemical processes controlling metal and nutrient cycles and the fate of contaminants. In this context, the influence of competitive sorption effects between Fe(II) and other relevant transition metals on their uptake characteristics and mobility remains an important issue. Macroscopic sorption experiments combined with surface complexation modeling and extended X-ray absorption fine structure (EXAFS) spectroscopy were applied to elucidate competitive sorption processes between divalent Fe and Zn at the clay mineral-water interface. Sorption isotherms were measured on a synthetic iron-free montmorillonite (IFM) under anoxic conditions (O2 <0.1 ppm) for the combinations of Zn(II)/Fe(II) and Fe(II)/Zn(II), where the former metal in each pair represents the trace metal (<10(-7) M) and the latter the competing metal at higher concentrations (10(-7) to 10(-3) M). Results of the batch sorption and EXAFS measurements indicated that Fe(II) is competing with trace Zn(II) for the same type of strong sites if Fe(II) is present in excess, whereas no competition between trace Fe(II) and Zn(II) was observed if Zn(II) is present at high concentrations. The noncompetitive behavior suggests the existence of sorption sites which have a higher affinity for Fe(III), where surface-induced oxidation of the sorbed Fe(II) to Fe(III) occurred, and which are not accessible for Zn(II). The understanding of this competitive uptake mechanism between Fe(II) and Zn(II) is of great importance to assess the bioavailability and mobility of transition metals in the natural environment. PMID:24289476

  9. Co(II)-chloride and -bromide complexes in aqueous solutions up to 5 m NaX and 90 degree C: Spectrophotometric study and geological implications

    SciTech Connect

    Pan, Pujing; Susak, N.J. )

    1989-02-01

    Absorption spectra of Co(II)-chloride and bromide complexes have been taken in the UV-visible-NIR region, at temperatures from 25 to 90{degree}C. The octahedral absorption bands have been resolved into components by fitting to Gaussian distribution functions, and the resolved bands have been assigned to ligand-field transitions using Tanabe-Sugano diagrams. The ligand-field-splitting energies, 10 Dq, were obtained for both chloro- and bromo-cobaltous complexes. These data were then used to estimate the average chloro-ligation number at each temperature and the chloride concentrations. It is possible to factor total dissolved cobalt in a fluid into two terms, a free cobalt term and an enhancement term due to chloride complexation. Investigation of each of the terms shows that under typical, low-temperature hydrothermal conditions, several ppm cobalt can be dissolved in natural fluids, provided that a sufficient source of cobalt is present. For major cobalt mineralization to occur, environmental conditions which produce a high free cobalt term and very high salinities are required, in addition to a sufficient source of cobalt.

  10. A N-heterocyclic tetracarbene Pd(ii) moiety containing a Pd(ii)-Pb(ii) bimetallic MOF for three-component cyclotrimerization via benzyne.

    PubMed

    Dong, Ying; Li, Yue; Wei, Yong-Liang; Wang, Jian-Cheng; Ma, Jian-Ping; Ji, Jun; Yao, Bing-Jian; Dong, Yu-Bin

    2016-08-18

    A novel Pd(ii)-Pb(ii) bimetallic metal-organic framework Pd(ii)-Pb(ii)-MOF (B) which contains an N-heterocyclic tetracarbene Pd(ii) moiety was synthesized based on a chelating N-heterocyclic dicarbene Pd(ii)-NHDC ligand (A) under solvothermal conditions. It can be a highly active heterogeneous catalyst for three-component cyclotrimerization via benzyne species.

  11. Preschool Racial Attitude Measure II (PRAM II): Technical Report #1: 1970-71 Standardization Study.

    ERIC Educational Resources Information Center

    Williams, John E.

    This report provides detailed technical information concerning the Preschool Racial Attitude Measure II (PRAM II) a method for assessing the attitudes of pre-literate children toward light- and dark-skinned individuals. Several major changes were involved in the PRAM II revision: (1) the length was doubled, (2) the general artistic quality of the…

  12. 40 CFR Table II-2 to Subpart II - Collection Efficiencies of Anaerobic Processes

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Collection Efficiencies of Anaerobic Processes II Table II-2 to Subpart II Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt....

  13. 40 CFR Table II-2 to Subpart II - Collection Efficiencies of Anaerobic Processes

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Collection Efficiencies of Anaerobic Processes II Table II-2 to Subpart II Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt....

  14. Diet History Questionnaire II & Canadian Diet History Questionnaire II: Web-based DHQ

    Cancer.gov

    The Web-based versions of DHQ II and C-DHQ II are identical in content to the paper forms. By automating the DHQ II and providing versions on the Web for public use, researchers have another tool to collect and analyze food frequency questionnaire data.

  15. FOREWORD: HELAS II International Conference

    NASA Astrophysics Data System (ADS)

    Gizon, Laurent; Roth, Markus

    2008-07-01

    Volume 118 (2008) of Journal of Physics: Conference Series provides a written record of the talks and posters presented at the HELAS II International Conference `Helioseismology, Asteroseismology and MHD Connections'. The conference was held during the week 20-24 August 2007 in Göttingen, Germany, jointly hosted by the Max Planck Institute for Solar System Research and the Faculty of Physics of the University of Göttingen. A total of 140 scientists from all over the world attended. The Scientific Organizing Committee consisted of Conny Aerts, Annie Baglin, Jørgen Christensen-Dalsgaard, Thierry Corbard, Jadwiga Daszyńska-Daszkiewicz, Stefan Dreizler, Yvonne Elsworth, Laurent Gizon (Chairman), Wolfgang Glatzel, Frank Hill, Donald Kurtz, Oskar von der Lühe, Maria Pia Di Mauro, Mário Monteiro, Pere Pallé, Markus Roth, Philip Scherrer, Manfred Schüssler, and Michael Thompson. HELAS stands for the European Helio- and Asteroseismology Network, a Coordination Action supported by the sixth Framework Programme of the European Union. It aims to bring together researchers in the fields of solar and stellar oscillations. This volume consists of 91 articles organized into sections that reflect the scientific programme of the conference: 012001-07 Wave diagnostics in physics, geophysics and astrophysics 012008-09 Perspectives on helio- and asteroseismology 012010-17 Asteroseismology: Observations 012018-25 Asteroseismology: Theory 012026-32 Global helioseismology and solar models 012033-38 Local helioseismology and magnetic activity 012039-44 Future observational projects in helio- and asteroseismology 012045-91 Poster papers. The overwhelming majority of papers discuss the seismology of the Sun and stars. Papers in the first section provide a broader perspective on wave phenomena and techniques for probing other physical systems, from living beings to the universe as a whole. We were extremely fortunate to have particularly distinguished experts to cover these topics

  16. Adsorption of Cd(II), Cu(II) and Ni(II) ions by cross-linking chitosan/rectorite nano-hybrid composite microspheres.

    PubMed

    Zeng, Lixuan; Chen, Yufei; Zhang, Qiuyun; Guo, Xingmei; Peng, Yanni; Xiao, Huijuan; Chen, Xiaocheng; Luo, Jiwen

    2015-10-01

    Chitosan/rectorie (CTS/REC) nano-hybrid composite microsphere was prepared by changing the proportion of CTS/REC with 2:1, 3:1 and 4:1. Compared with the pure cross-linking chitosan microsphere, the nano-hybrid composite microsphere was proved to have better sorption capacity of Cd(II), Cu(II) and Ni(II), especially 2:1(CTS/REC-1). The adsorption behavior of the microsphere of Cd(II), Cu(II) and Ni(II) was investigated in single and binary metal systems. In single system, the equilibrium studies showed that the adsorption of Cd(II), Cu(II) and Ni(II) followed the Langmuir model and the pseudo-second-order kinetic model. The negative values of (ΔG) suggested that the adsorption process was spontaneous. In binary system, the combined action of the metals was found to be antagonistic and the metal sorption followed the order of Cu(II)>Cd(II)>Ni(II). The regeneration studies indicated that EDTA desorbed Cd(II), Cu(II) and Ni(II) from cross-linking microspheres better than HCl. The FT-IR and XPS spectra showed that coordination bonds were formed between Cd(II), Cu(II) and Ni(II) and the nitrogen atoms of cross-linking CTS/REC nano-hybrid composite microspheres. PMID:26076634

  17. Synthesis, DFT Calculation, and Antimicrobial Studies of Novel Zn(II), Co(II), Cu(II), and Mn(II) Heteroleptic Complexes Containing Benzoylacetone and Dithiocarbamate

    PubMed Central

    Ekennia, Anthony C.; Onwudiwe, Damian C.; Olasunkanmi, Lukman O.; Osowole, Aderoju A.; Ebenso, Eno E.

    2015-01-01

    Heteroleptic complexes of zinc(II), copper(II), manganese(II), and cobalt(II) of the types [MLL′(H2O)2]·nH2O and [MLL′]·nH2O have been synthesized using sodium N-methyl-N-phenyldithiocarbamate (L) and benzoylacetone (L′). The metal complexes were characterized by elemental analysis, electrical conductance, magnetic susceptibility, infrared (IR), and UV-visible spectroscopic studies. The electrical conductance measurements revealed the nonelectrolytic nature of the synthesized complexes. The results of the elemental analyses, magnetic susceptibility measurements, and electronic spectra inferred that the Zn(II) complex adopted a four-coordinate geometry while the Co(II), Cu(II), and Mn(II) complexes assumed octahedral geometries. The IR spectra showed that the metal ions coordinated with the ligands via the S- and O-donor atoms. The geometry, electronic, and thermodynamic parameters of the complexes were obtained from density functional theory (DFT) calculations. The spin density distributions, relative strength of H–bonds, and thermodynamic parameters revealed that the order of stability of the metal complexes is Mn < Co < Cu > Zn. The agar diffusion methods were used to study the antimicrobial activity of the complexes against two Gram positive bacteria (S. aureus and S. pneumoniae), one Gram negative bacterium (E. coli), and two fungi organisms (A. niger and A. candida) and the complexes showed a broad spectrum of activities against the microbes. PMID:26681931

  18. Arkansas HEA Title II. State Report, 2004

    ERIC Educational Resources Information Center

    Arkansas Department of Education, 2005

    2005-01-01

    In October 1998, Congress enacted Title II, Sections 207 and 208 (as amendments to the Higher Education Act) which support the efforts of States, Institutions of Higher Education, and their School District partners to improve the recruitment, preparation, and support of new teachers. The Title II report includes specifications, conditions and…

  19. Micro Channel/Multibus-II Interface Circuit

    NASA Technical Reports Server (NTRS)

    D'Ambrose, John J.; Jaworski, Richard C.; Heise, Nyles N.; Thornton, David N.

    1991-01-01

    Micro Channel/Multibus-II interface circuit provides electrical interconnections enabling communications between Micro Channels of IBM Personal System/2 computers and IEEE 1296 standard Multibus-II parallel system bus (iPSB). Made mostly of commercially available parts, interface enables independent Micro Channels to communicate over iPSB without modification.

  20. Run II data analysis on the grid

    SciTech Connect

    Igor Mandrichenko, Igor Terekhov and Frank Wurthwein

    2002-12-02

    In this document, we begin the technical design for the distributed RunII computing for CDF and D0. The present paper defines the three components of the data handling area of Run II computing, namely the Data Handling System, the Storage System and the Application. We outline their functionality and interaction between them. We identify necessary and desirable elements of the interfaces.

  1. The CDF SVX II detector upgrade

    SciTech Connect

    Skarha, J.E.

    1993-10-01

    The proposed CDF SVX II detector upgrade for secondary vertex detection during the Fermilab Tevatron Run II collider run is described. The general design and important features of this silicon vertex detector are presented. The CDF physics goals which are addressed by this detector are also given.

  2. World War II: A Technology Lesson Plan.

    ERIC Educational Resources Information Center

    Hagar, Suzy

    1990-01-01

    Presents a class activity on the history, causes, and consequences of World War II. Focuses on the development and deployment of the atomic bomb. Utilizes a Video Encyclopedia Program for historical background. Divides the class into groups that are responsible for researching and preparing a videotape on a World War II topic. (RW)

  3. Geology of the Phase II System

    SciTech Connect

    Laney, R.; Laughlin, A. William

    1980-11-19

    This is a report on the analysis of EE-2 cuttings and thin sections, geologic characterization of the Phase II system, comparison with Phase 1, and geologic speculations and recommendations concerning Phase II. The EE-2 litholog has been included in the pocket.

  4. Syntheses of Arnottin I and Arnottin II

    PubMed Central

    Moschitto, Matthew J.; Anthony, David R.; Lewis, Chad A.

    2015-01-01

    Short total syntheses of arnottin I and II were accomplished in 5 and 6 steps, respectively. A sesamol-benzyne cycloaddition with a 3-furyl-benzoate followed by regiospecific lactonization provided rapid, large-scale access to the core of arnottin I. Saponification of arnottin I and hypervalent iodide mediated spirocyclization provided an efficient and direct preparation of racemic arnottin II. PMID:25748275

  5. The CNET Automated Budget System (CABS) II.

    ERIC Educational Resources Information Center

    Middleton, Morris G.; And Others

    The Chief of Naval Education and Training (CNET) Automated Budget System II (CABS II) is an improved and expanded version of an earlier system which was developed by the Training Analysis and Evaluation Group (TAEG) to provide an efficient, easy means of handling the large volume of data necessary to produce budget documents. Intended as a guide…

  6. Biology II Curriculum Guide. Bulletin 1820.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Div. of Academic Programs.

    In 1986, the Louisiana State Board of Elementary and Secondary Education requested that an advanced course in Biology II be developed. The resulting curriculum guide contains grade appropriate goals, skills, and competencies; suggested activities; suggested materials of instruction; and minimum time allotments for instruction. Biology II is a…

  7. TRUPACT-II procedures and maintenance instructions

    SciTech Connect

    1994-01-14

    The purpose of this document is to provide the technical requirements for operation, inspection and maintenance of a TRUPACT-II Shipping Package and directly related components. This document shall supply the minimum requirements as specified in the TRUPACT-II Safety Analysis Report for Packaging (SARP) and Certificate of Compliance (C of C) 9218. In the event there is a conflict between this document and the TRUPACT-II SARP (NRC Certificate of Compliance No. 9218), the TRUPACT-II SARP shall govern. This document details the operations, maintenance, repair, replacement of components, as well as the documentation required and the procedures to be followed to maintain the integrity of the TRUPACT-II container. These procedures may be modified for site use, but as a minimum all parameters and format listed herein must be included in any site modified version. For convenience and where applicable steps may be performed out of sequence. Packaging and payload handling equipment and transport trailers have been specifically designed for use with the TRUPACT-II Packaging. This document discusses the minimum required procedures for use of the adjustable center of gravity lift fixture and the TRUPACT-II transport trailer in conjunction with the TRUPACT-II Packaging.

  8. World War II Memorial Learning Activities.

    ERIC Educational Resources Information Center

    Tennessee State Dept. of Education, Nashville.

    These learning activities can help students get the most out of a visit to the Tennessee World War II Memorial, a group of ten pylons located in Nashville (Tennessee). Each pylon contains informational text about the events of World War II. The ten pylons are listed as: (1) "Pylon E-1--Terror: America Enters the War against Fascism, June 1940";…

  9. First Run II results from CDF

    SciTech Connect

    S. Donati

    2002-06-04

    In this paper we report on the first run II results from the CDF experiment. A brief description of the Tevatron collider and CDF detector upgrades and performance achieved in the first part of run II is followed by the CDF expectations in the fields of beauty, top, electroweak and Higgs physics.

  10. Hearing Restoration in Neurofibromatosis Type II Patients

    PubMed Central

    Lee, Jeon Mi; Chang, Jin Woo; Choi, Jae Young

    2016-01-01

    Patients with neurofibromatosis type II will eventually succumb to bilateral deafness. For patients with hearing loss, modern medical science technology can provide efficient hearing restoration through a number of various methods. In this article, several hearing restoration methods for patients with neurofibromatosis type II are introduced. PMID:27189272

  11. World War II Homefront: A Historiography.

    ERIC Educational Resources Information Center

    Winkler, Allan M.

    2002-01-01

    Highlights the scholarship that exists on the World War II homefront covering topics such as World War II as a good war, Franklin D. Roosevelt, economic policy, propaganda, status of women and women's employment, the role of African Americans, racial violence, and the Japanese American experience. (CMK)

  12. Synthesis, DFT Calculation, and Antimicrobial Studies of Novel Zn(II), Co(II), Cu(II), and Mn(II) Heteroleptic Complexes Containing Benzoylacetone and Dithiocarbamate.

    PubMed

    Ekennia, Anthony C; Onwudiwe, Damian C; Olasunkanmi, Lukman O; Osowole, Aderoju A; Ebenso, Eno E

    2015-01-01

    Heteroleptic complexes of zinc(II), copper(II), manganese(II), and cobalt(II) of the types [MLL'(H2O)2]·nH2O and [MLL']·nH2O have been synthesized using sodium N-methyl-N-phenyldithiocarbamate (L) and benzoylacetone (L'). The metal complexes were characterized by elemental analysis, electrical conductance, magnetic susceptibility, infrared (IR), and UV-visible spectroscopic studies. The electrical conductance measurements revealed the nonelectrolytic nature of the synthesized complexes. The results of the elemental analyses, magnetic susceptibility measurements, and electronic spectra inferred that the Zn(II) complex adopted a four-coordinate geometry while the Co(II), Cu(II), and Mn(II) complexes assumed octahedral geometries. The IR spectra showed that the metal ions coordinated with the ligands via the S- and O-donor atoms. The geometry, electronic, and thermodynamic parameters of the complexes were obtained from density functional theory (DFT) calculations. The spin density distributions, relative strength of H-bonds, and thermodynamic parameters revealed that the order of stability of the metal complexes is Mn < Co < Cu > Zn. The agar diffusion methods were used to study the antimicrobial activity of the complexes against two Gram positive bacteria (S. aureus and S. pneumoniae), one Gram negative bacterium (E. coli), and two fungi organisms (A. niger and A. candida) and the complexes showed a broad spectrum of activities against the microbes. PMID:26681931

  13. Inhibition of topoisomerase II by liriodenine.

    PubMed

    Woo, S H; Reynolds, M C; Sun, N J; Cassady, J M; Snapka, R M

    1997-08-15

    The cytotoxic oxoaporphine alkaloid liriodenine, isolated from Cananga odorata, was found to be a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro. Liriodenine treatment of SV40 (simian virus 40)-infected CV-1 cells caused highly catenated SV40 daughter chromosomes, a signature of topoisomerase II inhibition. Strong catalytic inhibition of topoisomerase II by liriodenine was confirmed by in vitro assays with purified human topoisomerase II and kinetoplast DNA. Liriodenine also caused low-level protein-DNA cross-links to pulse-labeled SV40 chromosomes in vivo, suggesting that it may be a weak topoisomerase II poison. This was supported by the finding that liriodenine caused topoisomerase II-DNA cross-links in an in vitro assay for topoisomerase II poisons. Verapamil did not increase either liriodenine-induced protein-DNA cross-links or catalytic inhibition of topoisomerase II in SV40-infected cells. This indicates that liriodenine is not a substrate for the verapamil-sensitive drug efflux pump in CV-1 cells. PMID:9313773

  14. Angiotensin II disrupts inhibitory avoidance memory retrieval.

    PubMed

    Bonini, Juliana S; Bevilaqua, Lia R; Zinn, Carolina G; Kerr, Daniel S; Medina, Jorge H; Izquierdo, Iván; Cammarota, Martín

    2006-08-01

    The brain renin-angiotensin system (RAS) is involved in learning and memory, but the actual role of angiotensin II (A(II)) and its metabolites in this process has been difficult to comprehend. This has been so mainly due to procedural issues, especially the use of multi-trial learning paradigms and the utilization of pre-training intracerebroventricular infusion of RAS-acting compounds. Here, we specifically analyzed the action of A(II) in aversive memory retrieval using a hippocampal-dependent, one-trial, step-down inhibitory avoidance task (IA) in combination with stereotaxically localized intrahippocampal infusion of drugs. Rats bilaterally implanted with infusion cannulae aimed to the CA1 region of the dorsal hippocampus were trained in IA and tested for memory retention 24 h later. We found that when given into CA1 15 min before IA memory retention test, A(II), but not angiotensin IV or angiotensin(1-7) induced a dose-dependent and reversible amnesia without altering locomotor activity, exploratory behavior or anxiety state. The effect of A(II) was blocked in a dose-dependent manner by the A(II)-type 2 receptor (AT(2)) antagonist PD123319 but not by the A(II)-type 1 receptor (AT(1)) antagonist losartan. By themselves, neither PD123319 nor losartan had any effect on memory expression. Our data indicate that intra-CA1 A(II) hinders retrieval of avoidance memory through a process that involves activation of AT(2) receptors.

  15. Special issue "International CAWSES-II Symposium"

    NASA Astrophysics Data System (ADS)

    Yamamoto, Mamoru; Shiokawa, Kazuo; Nakamura, Takuji; Gopalswamy, Nat

    2016-02-01

    This special issue gathered papers from the International CAWSES-II Symposium (November 18-22, 2013 at Nagoya University, Japan). Climate and Weather of the Sun-Earth System II (CAWSES-II) is an international scientific program sponsored by Scientific Committee on Solar-Terrestrial Physics (SCOSTEP) that continued from 2009 to 2013. The program was established with the aim of significantly enhancing our understanding of the space environment and its impacts on life and society. The International CAWSES-II Symposium was successful with 388 presentations; and from that, 38 papers were published in this special issue. In this preface, we briefly discuss the contents of the special issue as well as the CAWSES-II review papers published in Progress in Earth and Planetary Science (PEPS) in 2014-2015.

  16. TRUPACT-II Operating and Maintenance Instructions

    SciTech Connect

    Westinghouse Electric Corporation, Waste Isolation Division

    1999-12-31

    The purpose of this document is to provide the technical requirements for preparation for use, operation, inspection, and maintenance of a Transuranic Package Transporter Model II (TRUPACT-II) Shipping Package and directly related components. This document complies with the minimum requirements as specified in the TRUPACT-II Safety Analysis Report for Packaging (SARP) and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9218. In the event there is a conflict between this document and the TRUPACT-II SARP, the TRUPACT-II SARP shall govern. TRUPACT-II C of C number 9218 states, ''... each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application.'' It further states, ''... each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the application.'' Chapter 9 of the TRUPACT-II SARP charges the Westinghouse Electric Corporation Waste Isolation Division (WID) with assuring that the TRUPACT-II is used in accordance with the requirements of the C of C. To meet this requirement and verify consistency of operations when loading and unloading the TRUPACT-II on the trailer, placing a payload in the packaging, unloading the payload from the packaging, or performing maintenance, the U.S. Department of Energy Carlsbad Area Office (U.S. DOE/CAO) finds it necessary to implement the changes that follow. This TRUPACT-II maintenance document represents a change to previous philosophy regarding site specific procedures for the use of the TRUPACT-II. This document details the instructions to be followed to consistently operate and maintain the TRUPACT-II. The intent of these instructions is to ensure that all users of the TRUPACT-II follow the same or equivalent instructions. Users may achieve this intent by any of the following methods: (1) Utilizing these instructions as is, or (2

  17. TRUPACT-II, a regulatory perspective

    SciTech Connect

    Gregory, P.C.; Spooner, O.R.

    1995-12-31

    The Transuranic Package Transporter II (TRUPACT-II) is a US Nuclear Regulatory Commission (NRC) certified Type B packaging for the shipment of contact-handled transuranic (CH-TRU) material by the US Department of Energy (DOE). The NRC approved the TRUPACT-II design as meeting the requirements of Title 10, Code of Federal Regulations, Part 71 (10 CFR 71) and issued Certificate of Compliance (CofC) Number 9218 to the DOE. There are currently 15 certified TRUPACT-IIs. Additional TRUPACT-IIs will be required to make more than 15,000 shipments of CH-TRU waste to the Waste Isolation Pilot Plant (WIPP) site near Carlsbad, New Mexico. The TRUPACT-II may also be used for the DOE inter-site and intra-site shipments of CH-TRU waste. The Land Withdrawal Act (Public Law 102-579), enacted by the US Congress, October 30, 1992, and an agreement between the DOE and the State of New Mexico, signed August 4, 1987, both stipulate that only NRC approved packaging may be used for shipments of TRU waste to the WIPP. Early in the TRUPACT-II development phase it was decided that the transportation system (tractor, trailer, and TRUPACT-II) should be highway legal on all routes without the need for oversize and/or overweight permits. In large measure, public acceptance of the DOE`s efforts to safely transport CH-TRU waste depends on the public`s perception that the TRUPACT-II is in compliance with all applicable regulations, standards, and quality assurance requirements. This paper addresses some of the numerous regulations applicable to Type B packaging, and it describes how the TRUPACT-II complies with these regulations.

  18. Intracellular angiotensin II activates rat myometrium.

    PubMed

    Deliu, Elena; Tica, Andrei A; Motoc, Dana; Brailoiu, G Cristina; Brailoiu, Eugen

    2011-09-01

    Angiotensin II is a modulator of myometrial activity; both AT(1) and AT(2) receptors are expressed in myometrium. Since in other tissues angiotensin II has been reported to activate intracellular receptors, we assessed the effects of intracellular administration of angiotensin II via microinjection on myometrium, using calcium imaging. Intracellular injection of angiotensin II increased cytosolic Ca(2+) concentration ([Ca(2+)](i)) in myometrial cells in a dose-dependent manner. The effect was abolished by the AT(1) receptor antagonist losartan but not by the AT(2) receptor antagonist PD-123319. Disruption of the endo-lysosomal system, but not that of Golgi apparatus, prevented the angiotensin II-induced increase in [Ca(2+)](i). Blockade of AT(1) receptor internalization had no effect, whereas blockade of microautophagy abolished the increase in [Ca(2+)](i) produced by intracellular injection of angiotensin II; this indicates that microautophagy is a critical step in transporting the peptide into the endo-lysosomes lumenum. The response to angiotensin II was slightly reduced in Ca(2+)-free saline, indicating a major involvement of Ca(2+) release from internal stores. Blockade of inositol 1,4,5-trisphosphate (IP(3)) receptors with heparin and xestospongin C or inhibition of phospholipase C (PLC) with U-73122 abolished the response to angiotensin II, supporting the involvement of PLC-IP(3) pathway. Angiotensin II-induced increase in [Ca(2+)](i) was slightly reduced by antagonism of ryanodine receptors. Taken together, our results indicate for the first time that in myometrial cells, intracellular angiotensin II activates AT(1)-like receptors on lysosomes and activates PLC-IP(3)-dependent Ca(2+) release from endoplasmic reticulum; the response is further augmented by a Ca(2+)-induced Ca(2+) release mechanism via ryanodine receptors activation.

  19. Standards in neurosonology. Part II

    PubMed Central

    Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2016-01-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-to-left shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity). PMID:27104002

  20. Ozone Conference II: Abstract Proceedings

    SciTech Connect

    1999-11-01

    Ozone Conference II: Pre- and Post-Harvest Applications Two Years After Gras, was held September 27-28, 1999 in Tulare, California. This conference, sponsored by EPRI's Agricultural Technology Alliance and Southern California Edison's AgTAC facility, was coordinated and organized by the on-site ATA-AgTAC Regional Center. Approximately 175 people attended the day-and-a-half conference at AgTAC. During the Conference twenty-two presentations were given on ozone food processing and agricultural applications. Included in the presentations were topics on: (1) Ozone fumigation; (2) Ozone generation techniques; (3) System and design applications; (4) Prewater treatment requirements; (5) Poultry water reuse; (6) Soil treatments with ozone gas; and (7) Post-harvest aqueous and gaseous ozone research results. A live videoconference between Tulare and Washington, D.C. was held to discuss the regulators' view from inside the beltway. Attendees participated in two Roundtable Question and Answer sessions and visited fifteen exhibits and demonstrations. The attendees included university and governmental researchers, regulators, consultants and industry experts, technology developers and providers, and corporate and individual end-users. This report is comprised of the Abstracts of each presentation, biographical sketches for each speaker and a registration/attendees list.

  1. Standards in neurosonology. Part II.

    PubMed

    Wojczal, Joanna; Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2016-03-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-to-left shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity).

  2. Early failure of Class II resin composite versus Class II amalgam restorations placed by dental students.

    PubMed

    Overton, J D; Sullivan, Diane J

    2012-03-01

    Using the information from remake request slips in a dental school's predoctoral clinic, we examined the short-term survival of Class II resin composite restorations versus Class II dental amalgam restorations. In the student clinic, resin composite is used in approximately 58 percent of Class II restorations placed, and dental amalgam is used in the remaining 42 percent. In the period examined, Class II resin composite restorations were ten times more likely to be replaced at no cost to the patient than Class II dental amalgam restorations. A total of eighty-four resin composite restorations and six amalgam restorations were replaced due to an identified failure.

  3. Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene

    NASA Astrophysics Data System (ADS)

    El-Sherif, Ahmed A.; Eldebss, Taha M. A.

    2011-09-01

    Schiff base namely 2-aminomethylthiophenyl-4-bromosalicylaldehyde (ATS)(4-bromo-2-(thiophen-2-yl-imino)methylphenol) and its metal complexes have been synthesized and characterized by elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, ESR and thermal analysis (TGA). The analytical data of the complexes show the formation of 1:2 [M:L] ratio of the formula [ML 2], where M represents Ni(II), Zn(II) and Cu(II) ions, while L represents the deprotonated Schiff base. IR spectra show that ATS is coordinated to the metal ions in a bidentate manner through azomethine-N and phenolic-oxygen groups. The ligand and their metal chelates have been screened for their antimicrobial activities using the disc diffusion method against the selected bacteria. A cytotoxicity of the compounds against colon (HCT116) and larynx (HEP2) cancer cells have been studied. Protonation constants of (ATS) ligand and stability constants of its Cu 2+, Co 2+, Mn 2+, Zn 2+ and Ni 2+ complexes were determined by potentiometric titration method in 50% (v/v) DMSO-water solution at ionic strength of 0.1 M NaNO 3.

  4. Adsorption of Cu(II), Hg(II), and Ni(II) ions by modified natural wool chelating fibers.

    PubMed

    Monier, M; Ayad, D M; Sarhan, A A

    2010-04-15

    The graft copolymerization of ethyl acrylate (EA) onto natural wool fibers initiated by potassium persulphate and Mohr's salt redox initiator system in limited aqueous medium was carried out in heterogeneous media. Ester groups of the grafted copolymers were partially converted into hydrazide function groups followed by hydrazone formation through reaction with isatin. Also the application of the modified fibers for metal ion uptake was studied using Cu(II), Hg(II) and Ni(II). The modified chelating fibers were characterized using FTIR spectroscopy, SEM and X-ray diffraction. PMID:19962235

  5. Effects of Mg II and Ca II ionization on ab-initio solar chromosphere models

    NASA Technical Reports Server (NTRS)

    Rammacher, W.; Cuntz, M.

    1991-01-01

    Acoustically heated solar chromosphere models are computed considering radiation damping by (non-LTE) emission from H(-) and by Mg II and Ca II emission lines. The radiative transfer equations for the Mg II k and Ca II K emission lines are solved using the core-saturation method with complete redistribution. The Mg II k and Ca II K cooling rates are compared with the VAL model C. Several substantial improvements over the work of Ulmschneider et al. (1987) are included. It is found that the rapid temperature rises caused by the ionization of Mg II are not formed in the middle chromosphere, but occur at larger atmospheric heights. These models represent the temperature structure of the 'real' solar chromosphere much better. This result is a major precondition for the study of ab-initio models for solar flux tubes based on MHD wave propagation and also for ab-initio models for the solar transition layer.

  6. 1,8-Dihydroxyanthraquinone anchored on silica gel: synthesis and application as solid phase extractant for lead(II), zinc(II) and cadmium(II) prior to their determination by flame atomic absorption spectrometry.

    PubMed

    Goswami, Anupama; Singh, Ajai K

    2002-10-16

    A new chelating matrix has been prepared by immobilizing 1,8-dihydroxyanthraquinone (DHAQ) on silica gel modified with (3-aminopropyl)triethoxysilane. After characterizing the matrix with thermogravimetric analysis (TGA), cross polarization magic angle spinning (CPMAS) NMR and diffuse reflectance infrared fourier transformation (DRIFT) spectroscopy, it has been used to preconcentrate Pb(II), Cd(II) and Zn(II) prior to their determination by flame atomic absorption spectrometry. The optimum pH ranges for quantitative sorption are 6.0-7.5, 7.0-8.0 and 6.0-8.0 for Pb, Zn, and Cd, respectively. All the metal ions can be desorbed with 2 mol l(-1) HCl/HNO(3). The sorption capacity of the matrix has been found to be 76.0, 180.0 and 70.2 mumol g(-1) for Pb, Zn and Cd, respectively, with the preconcentration factor of approximately 200. The limits upto which electrolytes NaNO(3), NaCl, NaBr, Na(2)SO(4), Na(3)PO(4) sodium citrate, EDTA, glycine and humic acid and cations Ca(II), Mg(II), Cu(II), Co(II), Ni(II), Mn(II) Al(III), Cr(III) and Fe(III) can co-exist with the metal ions during their sorption without any adverse effect are reported. The lowest concentration of metal ions for quantitative recovery is 5.0 ng ml(-1) The simultaneous enrichment and determination of all the metals is possible if total load of metal ions is less than sorption capacity. The flame AAS was used to determine these metal ions in underground, tap and river water samples (relative standard deviation (R.S.D.)

  7. Use of APACHE II and SAPS II to predict mortality for hemorrhagic and ischemic stroke patients.

    PubMed

    Moon, Byeong Hoo; Park, Sang Kyu; Jang, Dong Kyu; Jang, Kyoung Sool; Kim, Jong Tae; Han, Yong Min

    2015-01-01

    We studied the applicability of the Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) in patients admitted to the intensive care unit (ICU) with acute stroke and compared the results with the Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS). We also conducted a comparative study of accuracy for predicting hemorrhagic and ischemic stroke mortality. Between January 2011 and December 2012, ischemic or hemorrhagic stroke patients admitted to the ICU were included in the study. APACHE II and SAPS II-predicted mortalities were compared using a calibration curve, the Hosmer-Lemeshow goodness-of-fit test, and the receiver operating characteristic (ROC) curve, and the results were compared with the GCS and NIHSS. Overall 498 patients were included in this study. The observed mortality was 26.3%, whereas APACHE II and SAPS II-predicted mortalities were 35.12% and 35.34%, respectively. The mean GCS and NIHSS scores were 9.43 and 21.63, respectively. The calibration curve was close to the line of perfect prediction. The ROC curve showed a slightly better prediction of mortality for APACHE II in hemorrhagic stroke patients and SAPS II in ischemic stroke patients. The GCS and NIHSS were inferior in predicting mortality in both patient groups. Although both the APACHE II and SAPS II systems can be used to measure performance in the neurosurgical ICU setting, the accuracy of APACHE II in hemorrhagic stroke patients and SAPS II in ischemic stroke patients was superior.

  8. [C II] and [N II] from dense ionized regions in the Galaxy

    NASA Astrophysics Data System (ADS)

    Langer, W. D.; Goldsmith, P. F.; Pineda, J. L.

    2016-05-01

    Context. The interstellar medium (ISM) consists of highly ionized and neutral atomic, as well as molecular, components. Knowledge of their distribution is important for tracing the structure and lifecycle of the ISM. Aims: To determine the properties of the highly ionized gas and neutral weakly ionized gas in the Galaxy traced by the fine-structure lines of ionized nitrogen, [N ii], and ionized carbon, [C ii]. Methods: We utilize observations of the [C ii] 158 μm and [N ii] 205 μm fine-structure lines taken with the high spectral resolution Heterodyne Instrument in the Far-Infrared (HIFI) on the Herschel Space Observatory along ten lines of sight towards the inner Galaxy to analyze the ionized ISM. The [N ii] emission can be used to estimate the contribution of the highly ionized gas to the [C ii] emission and separate the contributions from highly ionized and weakly ionized neutral gas. Results: We find that [N ii] has strong emission in distinct spectral features along all lines of sight associated with strong [C ii] emission. The [N ii] arises from moderate density extended H ii regions or ionized boundary layers of clouds. Comparison of the [N ii] and [C ii] spectra in 31 separate kinematic features shows that many of the [C ii] spectra are affected by absorption from low excitation gas associated with molecular clouds, sometimes strongly so. The apparent fraction of the [C ii] associated with the [N ii] gas is unrealistically large in many cases, most likely due to the reduction of [C ii] by absorption. In a few cases the foreground absorption can be modeled to determine the true source intensity. In these sources we find that the foreground absorbing gas layer has C+ column densities of order 1018 cm-2. Conclusions: [C ii] emission arising from strong sources of [N ii] emission is frequently absorbed by low excitation foreground gas complicating the interpretation of the properties of the ionized and neutral gas components that give rise to [C ii] emission.

  9. New Rh2(II,II) Architecture for the Catalytic Reduction of H⁺.

    PubMed

    White, Travis A; Witt, Suzanne E; Li, Zhanyong; Dunbar, Kim R; Turro, Claudia

    2015-10-19

    Formamidinate-bridged Rh2(II,II) complexes containing diimine ligands of the formula cis-[Rh2(II,II)(μ-DTolF)2(NN)2](2+) (Rh2-NN2), where DTolF = p-ditolylformamidinate and NN = dppn (benzo[i]dipyrido[3,2-a:2',3'-h]quinoxaline), dppz (dipyrido[3,2-a:2',3'-c]phenazine), and phen (1,10-phenanthroline), electrocatalytically reduce H(+) to H2 in DMF solutions containing CH3COOH at a glassy carbon electrode. Cathodic scans in the absence of acid display a Rh(III,II/II,II) reduction at -0.90 V vs Fc(+)/Fc followed by NN(0/-) reduction at -1.13, -1.36, and -1.65 V for Rh2-dppn2, Rh2-dppz2, and Rh2-phen2, respectively. Upon the addition of acid, Rh2-dppn2 and Rh2-dppz2 undergo reduction-protonation-reduction at each pyrazine-containing NN ligand prior to the Rh2(II,II/II,I) reduction. The Rh2(II,I) species is then protonated at one of the metal centers, resulting in the formation of the corresponding Rh2(II,III)-hydride. In the case of Rh2-phen2, the reduction of the phen ligand is followed by intramolecular electron transfer to the Rh2(II,II) core in the presence of protons to form a Rh2(II,III)-hydride species. Further reduction and protonation at the Rh2 core for all three complexes rapidly catalyzes H2 formation with varied calculated turnover frequencies (TOF) and overpotential values (η): 2.6 × 10(4) s(-1) and 0.56 V for Rh2-dppn, 2.8 × 10(4) s(-1) and 0.50 V for Rh2-dppz2, and 5.9 × 10(4) s(-1) and 0.64 V for Rh2-phen2. Bulk electrolysis confirmed H2 formation, and further CH3COOH addition regenerates H2 production, attesting to the robust nature of the architecture. The cis-[Rh2(II,II)(μ-DTolF)2(NN)2](2+) architecture benefits by combining electron-rich formamidinate bridges, a redox-active Rh2(II,II) core, and electron-accepting NN diimine ligands to allow for the electrocatalysis of H(+) substrate to H2 fuel.

  10. Chitosan film loaded with silver nanoparticles-sorbent for solid phase extraction of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II).

    PubMed

    Djerahov, Lubomir; Vasileva, Penka; Karadjova, Irina; Kurakalva, Rama Mohan; Aradhi, Keshav Krishna

    2016-08-20

    The present study describes the ecofriendly method for the preparation of chitosan film loaded with silver nanoparticles (CS-AgNPs) and application of this film as efficient sorbent for separation and enrichment of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II). The stable CS-AgNPs colloid was prepared by dispersing the AgNPs sol in chitosan solution at appropriate ratio and further used to obtain a cast film with very good stability under storage and good mechanical strength for easy handling in aqueous medium. The incorporation of AgNPs in the structure of CS film and interaction between the polymer matrix and nanoparticles were confirmed by UV-vis and FTIR spectroscopy. The homogeneously embedded AgNPs (average diameter 29nm, TEM analysis) were clearly observed throughout the film by SEM. The CS-AgNPs nanocomposite film shows high sorption activity toward trace metals under optimized chemical conditions. The results suggest that the CS-AgNPs nanocomposite film can be feasibly used as a novel sorbent material for solid-phase extraction of metal pollutants from surface waters.

  11. SEARCHING FOR NEW HYPERCOMPACT H II REGIONS

    SciTech Connect

    Sanchez-Monge, Alvaro; Pandian, Jagadheep D.; Kurtz, Stan

    2011-09-20

    Hypercompact (HC) H II regions are, by nature, very young H II regions, associated with the earliest stages of massive star formation. They may represent the transition phase as an early B-type star grows into an O-type star. Unfortunately, so few HC H II regions are presently known that their general attributes and defining characteristics are based on small number statistics. A larger sample is needed for detailed studies and good statistics. Class II methanol masers are one of the best indicators of the early stages of massive star formation. Using the Arecibo Methanol Maser Galactic Plane Survey-the most sensitive blind survey for 6.7 GHz methanol masers to date-we selected 24 HC H II region candidates. We made Expanded Very Large Array continuum observations at 3.6 and 1.3 cm to search for HC H II regions associated with these masers. We identified six potential HC H II regions in our sample based on the presence of optically thick free-free emission. Overall, we find that 30% of the methanol masers have an associated centimeter radio continuum source (separation less than 0.1 pc), which is in general agreement with previous studies.

  12. Angiotensin II: Immunohistochemical Study in Sardinian Pterygium

    PubMed Central

    Demurtas, P.; Corrias, M.; Zucca, I.; Piras, F.; Sirigu, P.; Perra, M.T.

    2014-01-01

    The Angiotensin II (Ang II) is the principal effector peptide of the RAS system. It has a pleiotropic effect and, beside its physiological role, it has the property to stimulate angiogenesis and activate multiple signalling pathways related to cell proliferation. The purpose of the study was to determinate the Ang II expression and localization in Sardinian pterygium and normal conjunctiva by immunohistochemistry, and its possible involvement in the development and progression of the disease. Twenty-three pterygiums and eleven normal conjunctiva specimens obtained from Sardinian patients, were processed for paraffin embedding and assessed for the immunohistochemi-cal revelation of Ang II. Significant Ang II expression was identified in pterygium and conjunctiva. Particularly, thirteen pterygium specimens (n=13) displayed exclusively moderate to strong nuclear staining; some specimens (n=5) showed exclusively a moderate cytoplasmic immunoreactivity, and few specimens (n=2) displayed moderate to strong immunoreactivity in both cytoplasm and nucleus. Only 3 specimens were negative. Statistical significance difference in respect of nuclear and cytoplasmic localization was observed between normal conjunctiva and pterygium (P=0.020). The results showed a predominant intranuclear localization of Ang II in pterygium epithelial cells, in spite of conjunctiva that mainly showed cytoplasmic localization. These findings suggest a possible role for Ang II in the development and/or progression of pterygium mediated by the activation of local RAS system. PMID:25308851

  13. 20 CFR 404.1342 - Limits on granting World War II and post-World War II wage credits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Limits on granting World War II and post-World War II wage credits. 404.1342 Section 404.1342 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... II and post-World War II wage credits. (a) You get wage credits for World War II or post-World......

  14. 20 CFR 404.1342 - Limits on granting World War II and post-World War II wage credits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Limits on granting World War II and post-World War II wage credits. 404.1342 Section 404.1342 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... II and post-World War II wage credits. (a) You get wage credits for World War II or post-World......

  15. 20 CFR 404.1342 - Limits on granting World War II and post-World War II wage credits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Limits on granting World War II and post-World War II wage credits. 404.1342 Section 404.1342 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... II and post-World War II wage credits. (a) You get wage credits for World War II or post-World......

  16. 20 CFR 404.1342 - Limits on granting World War II and post-World War II wage credits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Limits on granting World War II and post-World War II wage credits. 404.1342 Section 404.1342 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... II and post-World War II wage credits. (a) You get wage credits for World War II or post-World......

  17. 20 CFR 404.1342 - Limits on granting World War II and post-World War II wage credits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Limits on granting World War II and post-World War II wage credits. 404.1342 Section 404.1342 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... II and post-World War II wage credits. (a) You get wage credits for World War II or post-World......

  18. Angiotensin II receptors in testes

    SciTech Connect

    Millan, M.A.; Aguilera, G.

    1988-05-01

    Receptors for angiotensin II (AII) were identified and characterized in testes of rats and several primate species. Autoradiographic analysis of the binding of 125I-labeled (Sar1,Ile8)AII to rat, rhesus monkey, cebus monkey, and human testicular slide-mounted frozen sections indicated specific binding to Leydig cells in the interstitium. In rat collagenase-dispersed interstitial cells fractionated by Percoll gradient, AII receptor content was parallel to that of hCG receptors, confirming that the AII receptors are in the Leydig cells. In rat dispersed Leydig cells, binding was specific for AII and its analogs and of high affinity (Kd, 4.8 nM), with a receptor concentration of 15 fmol/10(6) cells. Studies of AII receptors in rat testes during development reveals the presence of high receptor density in newborn rats which decreases toward the adult age (4934 +/- 309, 1460 +/- 228, 772 +/- 169, and 82 +/- 12 fmol/mg protein at 5, 15, 20, and 30 days of age, respectively) with no change in affinity. At all ages receptors were located in the interstitium, and the decrease in binding was parallel to the decrease in the interstitial to tubular ratio observed with age. AII receptor properties in membrane-rich fractions from prepuberal testes were similar in the rat and rhesus monkey. Binding was time and temperature dependent, reaching a plateau at 60 min at 37 C, and was increased by divalent cations, EGTA, and dithiothreitol up to 0.5 mM. In membranes from prepuberal monkey testes, AII receptors were specific for AII analogs and of high affinity (Kd, 4.2 nM) with a receptor concentration of 7599 +/- 1342 fmol/mg protein. The presence of AII receptors in Leydig cells in rat and primate testes in conjunction with reports of the presence of other components of the renin-angiotensin system in the testes suggests that the peptide has a physiological role in testicular function.

  19. Light harvesting in photosystem II.

    PubMed

    van Amerongen, Herbert; Croce, Roberta

    2013-10-01

    Water oxidation in photosynthesis takes place in photosystem II (PSII). This photosystem is built around a reaction center (RC) where sunlight-induced charge separation occurs. This RC consists of various polypeptides that bind only a few chromophores or pigments, next to several other cofactors. It can handle far more photons than the ones absorbed by its own pigments and therefore, additional excitations are provided by the surrounding light-harvesting complexes or antennae. The RC is located in the PSII core that also contains the inner light-harvesting complexes CP43 and CP47, harboring 13 and 16 chlorophyll pigments, respectively. The core is surrounded by outer light-harvesting complexes (Lhcs), together forming the so-called supercomplexes, at least in plants. These PSII supercomplexes are complemented by some "extra" Lhcs, but their exact location in the thylakoid membrane is unknown. The whole system consists of many subunits and appears to be modular, i.e., both its composition and organization depend on environmental conditions, especially on the quality and intensity of the light. In this review, we will provide a short overview of the relation between the structure and organization of pigment-protein complexes in PSII, ranging from individual complexes to entire membranes and experimental and theoretical results on excitation energy transfer and charge separation. It will become clear that time-resolved fluorescence data can provide invaluable information about the organization and functioning of thylakoid membranes. At the end, an overview will be given of unanswered questions that should be addressed in the near future.

  20. Participation of angiotensin II in learning and memory. II. Interactions of angiotensin II with dopaminergic drugs.

    PubMed

    Yonkov, D I; Georgiev, V P; Opitz, M J

    1986-04-01

    The effect of angiotensin II (ATII) and of its interactions with dopaminergic drugs injected post-trial on retention in active avoidance tasks in shuttle-box-trained rats were studied. ATII at doses of 0.10 and 0.50 micrograms administered intracerebroventricularly (i.c.v.) immediately after training improved retention. The dopaminergic receptor agonist apomorphine at a dose of 0.10 mg/kg injected intraperitoneally (i.p.) facilitated retention whereas elymoclavine (a dopaminergic agonist) at a dose of 2.5 mg/kg i.p. had no effect. ATII at a dose of 0.10 micrograms i.c.v. administered after apomorphine 0.10 mg/kg or elymoclavine 2.5 mg/kg exerted a stronger retention-facilitating effect. The dopaminergic receptor antagonist haloperidol at a dose of 1 mg/kg i.p. markedly impaired retention. ATII at a dose of 0.50 micrograms administered after haloperidol (1 mg/kg) did not exercise its retention-facilitating effect. It is concluded that the retention facilitating effects of ATII are realized through interactions with brain dopaminergic transmission.

  1. Structures and stabilities of Cd(II) and Cd(II)-phthalate complexes at the goethite/water interface

    SciTech Connect

    Boily, Jean F.; Sjoberg, Staffan; Persson, Per

    2005-01-01

    The complexation of Cd(II) and Cd(II)-phthalate at the goethite/water interface were investigated by EXAFS and IR spectroscopy, by batch adsorption experiments and by potentiometric titrations at 298.15 K. The EXAFS spectra showed Cd(II) to form only inner-sphere corner-sharing complexes with the goethite surface sites in the presence and absence of phthalate. EXAFS spectra also showed the presence of Cd(II)-chloride complexes in 0.1 mol/L NaCl. IR spectra also showed phthalate to form (1) an inner-sphere complex with adsorbed corner-sharing Cd(II) surface complexes in the pH 3.5 to 9.5 and (2) an outer-sphere complex with the same type of corner-sharing Cd(II) complex however at pH > 6, in addition to the inner- and outer-sphere complexes of phthalate reported in a previous study. The potentiometric titration and the batch adsorption data were used to constrain the formation constants of the different Cd(II)-phthalate surface complexes on the dominant {110} and the {001} planes of the goethite. The models were carried out with the Charge Distribution Multisite Complexation model coupled to the Three Plane Model and can predict the molecular-scale speciation of cadmium and phthalate in the presence of goethite. Cd(II) adsorption models calibrated on a 90 m2/g goethite also could accurately predict experimental data for a 37 m2/g goethite of slightly different basic charging properties.

  2. Indium-111-Photofrin-II scintillation scan

    SciTech Connect

    Origitano, T.C.; Karesh, S.M.; Reichman, O.H.; Henkin, R.E.; Caron, M.J.

    1989-04-01

    Photodynamic therapy is under intense investigation as an adjuvant treatment for malignant glial tumors of the central nervous system. Photofrin-II (HpD-II) is currently the most actively investigated photosensitizing agent. A crucial issue regarding the safe and efficacious usage of HpD-II-based photodynamic therapy is the individual in vivo kinetics of tumor uptake and retention, compared with normal brain clearance. The optimal time for photoactivation of sensitized tumor must be known to ensure a high target-to-nontarget ratio, resulting in the maximal tumor destruction while preserving normal brain. Our laboratory developed a radionuclide scan based on 111indium (111In)-labeled HpD-II to evaluate HpD-II localization and clearance noninvasively within a canine model of intracerebral gliosarcoma. Synthesis of the 111In-HpD-II complex in greater than 90% yield is achieved by a simple, rapid labeling method. Radiochemical purity and stability were verified by high-performance liquid chromatography. Using the canine model of intracerebral gliosarcoma, we followed the uptake of 111In-HpD-II in tumors with serial scintillation scanning. Localization of the tumor by 111In-HpD-II has been verified by contrast-enhanced computed tomographic scan followed by gross and histological examination of the enhancing brain region. Total body biodistribution of 111In-HpD-II at various times after injection has been evaluated. The ratio of uptake in tumor compared with surrounding brain peaked at 72 hours after injection. The knowledge of regional distribution and concentration of a photosensitizing agent within a tumor mass and surrounding brain allows for the most efficacious timing and localization of a photoactivating source.

  3. Angiotensin II reduces calcium uptake into bone.

    PubMed

    Schurman, Scott J; Bergstrom, William H; Shoemaker, Lawrence R; Welch, Thomas R

    2004-01-01

    Children with neonatal Bartter syndrome (NBS) have hypercalciuria, nephrocalcinosis, and osteopenia. A complex of basic-fibroblast growth factor (b-FGF) and a naturally occurring glycosaminoglycan has been identified in the serum and urine of NBS patients. This complex increases bone resorption in a bone disc bioassay system. Angiotensin II (AT II), which is increased in Bartter syndrome, increases the synthesis of b-FGF by cultured endothelial cells. Addition of 10(-8) M AT II to the bioassay, a concentration reported in Bartter syndrome patients, significantly decreased calcium uptake into bone discs [E/C 0.60 (0.04), P < 0.001 compared with buffer, normal E/C >0.90]. Adding b-FGF monoclonal antibody at 10 microg/ml [E/C 0.90 (0.06), P=NS] or indomethacin [E/C 1.00 (0.03), P=NS] to 10(-8 )M AT II neutralized this effect. In separate experiments, newborn rats were given intraperitoneal injections of AT II. Bone discs from these animals were used in the bioassay system and calcium uptake was markedly reduced compared with discs from rats injected with phosphate-buffered saline [AT II 6.6 x 10(-9), E/C 0.10 (0.04), P<0.001, AT II 3.3 x 10(-8), E/C 0.10 (0.05), P<0.001]. AT II decreases calcium uptake in the bone disc bioassay system. This effect can be abrogated by antibody to b-FGF or prostaglandin synthetase inhibition. These results support the hypothesis that in children with NBS, elevated levels of AT II stimulate local skeletal b-FGF synthesis, with a resultant increase in bone resorption via a prostaglandin-dependent pathway. PMID:14648327

  4. Studies on Pt{sub x}In{sub y} bimetallics in NaY. II. Further characterization results and catalytic properties

    SciTech Connect

    Meriaudeau, P.; Thangaraj, A.; Dutel, J.F.; Gelin, P.; Naccache, C.

    1996-10-01

    In a previous paper the preparation and the characterization PtNaY and PtInNaY were reported. Here, complementary characterization results obtained by studying the TPD of CO by mass spectrometry coupled with IR studies of the adsorbed CO phases indicated no apparent change in the electronic properties of Pt. Comparison of catalytic properties for n-butane hydrogenolysis between PtNaY and PtInNaY indicated that the hydrogenolysis is deeply affected by the addition of In to Pt; the kinetic parameters (apparent activation energy, relative order for butane and for hydrogen) are modified by In addition. These results are explained considering that In is acting more like a diluent of Pt atoms than as an electronic modifier of Pt. 16 refs., 10 figs., 1 tab.

  5. Delta II development and flight results

    NASA Astrophysics Data System (ADS)

    Mihara, S. K.

    An account is given of the design modifications of the Delta launch vehicle which have resulted in its Delta II variant, together with flight results obtained with the Delta II to date. Delta II launchers feature a stretched LX tank, a larger-diameter satellite-payload fairing, and an expansion of first-stage nozzle expansion ratio from 8:1 to 12:1. The thrust-augmenting solid rocket boosters use graphite/epoxy composite motor cases. Both two-stage and three-stage launches are discussed, with attention to flights for the Navstar satellites.

  6. LHC II system sensitivity to magnetic fluids

    NASA Astrophysics Data System (ADS)

    Cotae, Vlad; Creanga, Ioan

    2005-03-01

    Experiments have been designed to reveal the influences of ferrofluid treatment and static magnetic field exposure on the photosynthetic system II, where the light harvesting complex (LHC II) controls the ratio chlorophyll a/ chlorophyll b (revealing, indirectly, the photosynthesis rate). Spectrophotometric measurement of chlorophyll content revealed different influences for relatively low ferrofluid concentrations (10-30 μl/l) in comparison to higher concentrations (70-100 μl/l). The overlapped effect of the static magnetic field shaped better the stimulatory ferrofluid action on LHC II system in young poppy plantlets.

  7. Pre- and initial stages of epitaxy in alkali halide systems. II. Interaction of molecular beams of CsCl with (100) surfaces of NaCl

    NASA Astrophysics Data System (ADS)

    Dabringhaus, H.; Haag, M.

    The interaction of molecular beams of CsCl with (100) surfaces of NaCl is studied for crystal temperatures between 560 and 620 K and for molecular beam fluxes between 2 × 10 7 and 2 × 10 13 cm -2 s -1 by measurements of transient and steady state desorption fluxes, by static SIMS, and by electron microscopy. Also for the large Cs + ions a fast cation exchange Cs + ⇌ Na + between CsCl molecules adsorbed on the terrace and the outermost surface layer of the NaCl crystal is observed. The results for undersaturation are interpreted by incorporation of Cs + ions in the outermost surface layer of the NaCl crystal and by adsorption of CsCl molecules at the monatomic steps on the surface. The outermost surface layer proves to have a maximum capacity for Cs + of 2.4 × 10 11 cm -2. The residence time of Cs + ions in the outermost surface layer is determined as τ0 = 1.6 × 10 -12 exp(1.49 (eV)/ kT), the time for desorption of CsCl molecules from the monatomic steps as τ1 = 2.9 × 10 -14 exp(1.60 (eV)/ kT). By experiments with an additional NaCl flux onto the surface it is shown that τ0 is the time for a back-exchange of Cs + ions from the outermost surface layer against Na + from NaCl admolecules. For supersaturation the growth of polymorphic CsCl islands is observed. In the first growth stages these islands show the NaCl-type structure, while for later growth stages the CsCl type structure is found. A comparative discussion of all studied alkali halide systems shows that the different results can be attributed to the different radii of guest and host cation and to lattice misfits, respectively.

  8. Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

    PubMed

    Murray, Justin K; Biswas, Kaustav; Holder, J Ryan; Zou, Anruo; Ligutti, Joseph; Liu, Dong; Poppe, Leszek; Andrews, Kristin L; Lin, Fen-Fen; Meng, Shi-Yuan; Moyer, Bryan D; McDonough, Stefan I; Miranda, Les P

    2015-11-01

    Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel NaV1.7 as new analgesics. Thus far, however, in vitro selectivity has proved difficult for small molecules, and peptides generally lack appropriate pharmacokinetic properties. We previously identified the NaV1.7 inhibitory peptide GpTx-1 from tarantula venom and optimized its potency and selectivity via structure-guided analoging. To further understand GpTx-1 binding to NaV1.7, we have mapped the binding site to transmembrane segments 1-4 of the second pseudosubunit internal repeat (commonly referred to as Site 4) using NaV1.5/NaV1.7 chimeric protein constructs. We also report that select GpTx-1 amino acid residues apparently not contacting NaV1.7 can be derivatized with a hydrophilic polymer without adversely affecting peptide potency. Homodimerization of GpTx-1 with a bifunctional polyethylene glycol (PEG) linker resulted in a compound with increased potency and a significantly reduced off-rate, demonstrating the ability to modulate the function and properties of GpTx-1 by linking to additional molecules. PMID:26112439

  9. Synthesis, characterization and anti-microbial evaluation of Cu(II), Ni(II), Pt(II) and Pd(II) sulfonylhydrazone complexes; 2D-QSAR analysis of Ni(II) complexes of sulfonylhydrazone derivatives

    NASA Astrophysics Data System (ADS)

    Özbek, Neslihan; Alyar, Saliha; Alyar, Hamit; Şahin, Ertan; Karacan, Nurcan

    2013-05-01

    Copper(II), nickel(II), platinum(II) and palladium(II) complexes with 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) derived from propanesulfonic acid-1-methylhydrazide (psmh) were synthesized, their structure were identified, and antimicrobial activity of the compounds was screened against three Gram-positive and three Gram-negative bacteria. The results of antimicrobial studies indicate that Pt(II) and Pd(II) complexes showed the most activity against all bacteria. The crystal structure of 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) was also investigated by X-ray analysis. A series of Ni(II) sulfonyl hydrazone complexes (1-33) was synthesized and tested in vitro against Escherichia coli and Staphylococcus aureus. Their antimicrobial activities were used in the QSAR analysis. Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO-LUMO energy gap play key roles in the antimicrobial activity.

  10. Genetics Home Reference: mucolipidosis II alpha/beta

    MedlinePlus

    ... Health Conditions mucolipidosis II alpha/beta mucolipidosis II alpha/beta Enable Javascript to view the expand/collapse ... PDF Open All Close All Description Mucolipidosis II alpha/beta (also known as I-cell disease) is ...

  11. Genetics Home Reference: distal hereditary motor neuropathy, type II

    MedlinePlus

    ... hereditary motor neuropathy, type II distal hereditary motor neuropathy, type II Enable Javascript to view the expand/ ... Open All Close All Description Distal hereditary motor neuropathy, type II is a progressive disorder that affects ...

  12. Selected methods for dissolved iron (II, III) and dissolved sulfide (-II) determinations in geothermal waters

    USGS Publications Warehouse

    Vivit, D.V.; Jenne, E.A.

    1985-01-01

    Dissolved sulfide (-II) and dissolved iron (II, III) were determined in geothermal well water samples collected at Cerro Prieto, Mexico. Most samples consisted of liquid and gas (two phases) at the instant of collection; and a subset of samples, referred to as ' flashed ' samples, consisted of pressurized steam samples which were allowed to condense. Sulfide was determined by sulfide specific ion electrode; Fe(II) and Fe(III) plus Fe(II) were determined spectrophotometrically. The precision and accuracy of the methods were evaluated for these high-silica waters with replicate analyses, spike recoveries, and an alternate method. Direct current (d.c.) argon plasma emission spectrometry was the alternate method used for Fe(III)-plus-Fe(II) analyses. Mean dissolved iron concentrations ranged from 20.2 to 834 micrograms/L (ug/L) as Fe(II) and 26.8 to 904 ug/L as Fe(III) plus Fe(II). Mean sulfide concentrations ranged from about 0.01 to 5.3 mg/L (S-II) Generally, higher S(-II) values and larger Fe(II)/Fe(III) ratios were found in the two-phase samples. These findings suggest that the ' flashed ' samples are at a less reduced state than the two-phase samples. (Author 's abstract)

  13. Kinetics of homogeneous and surface-catalyzed mercury(II) reduction by iron(II)

    USGS Publications Warehouse

    Amirbahman, Aria; Kent, Douglas B.; Curtis, Gary P.; Marvin-DiPasquale, Mark C.

    2013-01-01

    Production of elemental mercury, Hg(0), via Hg(II) reduction is an important pathway that should be considered when studying Hg fate in environment. We conducted a kinetic study of abiotic homogeneous and surface-catalyzed Hg(0) production by Fe(II) under dark anoxic conditions. Hg(0) production rate, from initial 50 pM Hg(II) concentration, increased with increasing pH (5.5–8.1) and aqueous Fe(II) concentration (0.1–1 mM). The homogeneous rate was best described by the expression, rhom = khom [FeOH+] [Hg(OH)2]; khom = 7.19 × 10+3 L (mol min)−1. Compared to the homogeneous case, goethite (α-FeOOH) and hematite (α-Fe2O3) increased and γ-alumina (γ-Al2O3) decreased the Hg(0) production rate. Heterogeneous Hg(0) production rates were well described by a model incorporating equilibrium Fe(II) adsorption, rate-limited Hg(II) reduction by dissolved and adsorbed Fe(II), and rate-limited Hg(II) adsorption. Equilibrium Fe(II) adsorption was described using a surface complexation model calibrated with previously published experimental data. The Hg(0) production rate was well described by the expression rhet = khet [>SOFe(II)] [Hg(OH)2], where >SOFe(II) is the total adsorbed Fe(II) concentration; khet values were 5.36 × 10+3, 4.69 × 10+3, and 1.08 × 10+2 L (mol min)−1 for hematite, goethite, and γ-alumina, respectively. Hg(0) production coupled to reduction by Fe(II) may be an important process to consider in ecosystem Hg studies.

  14. A new class of hybrid materials via salt inclusion: novel copper(II) arsenates Na(5)ACu(4)(AsO(4))(4)Cl(2) (A = Rb, Cs) composed of alternating covalent and ionic lattices.

    PubMed

    Hwu, Shiou-Jyh; Ulutagay-Kartin, Mutlu; Clayhold, Jeffrey A; Mackay, Richard; Wardojo, Tina A; O'Connor, Charles J; Krawiec, Mariusz

    2002-10-23

    Two novel copper(II) arsenates Na5ACu4(AsO4)4Cl2 (A = Rb, Cs) were synthesized by conventional solid-state methods using reactive molten salt media. These compounds are isostructural and crystallize in an orthorhombic lattice (Fmmm, No. 69; Z = 8). The cell constants are a = 14.632(3) A, b = 18.872(2) A, c = 14.445(3) A, V = 3989(1) A3, for A = Rb; a = 14.638(3) A, b = 18.990(4) A, c = 14.418(3) A, V = 4008(1) A3, for A = Cs. Single-crystal structure studies reveal a new composite framework consisting of alternating covalent and ionic lattices. The covalent lattice contains highly oriented oligomeric mu-oxo [Cu4O12]16- tetrameric units with a cyclo-S8-like Cu4O4 magnetic core that resembles the building block of layered cuprates. The ionic slab consists of a novel framework of mixed alkali metal chloride lattice and rarely seen Na6O8 clusters. Similar to organic-inorganic hybrid materials, the title compounds present a new class of host-guest chemistry via salt inclusion reactions.

  15. An uncertain role for Cu(II) in stimulating Mn(II) oxidation by Leptothrix discophora SS-1.

    PubMed

    El Gheriany, Iman A; Bocioaga, Daniela; Hay, Anthony G; Ghiorse, William C; Shuler, Michael L; Lion, Leonard W

    2011-02-01

    In an effort to improve understanding of the role of Cu(II) in bacterial Mn(II) oxidation, a model Mn(II)-oxidizing bacterium, Leptothrix discophora SS-1, was grown in presence of toxic and non-toxic concentrations of Cu(II), Cd(II) and Mn(II). Mn(II)-oxidizing activity increased by 40% when cells were grown in the presence of 0.05 microM of Cu(II) and increased twofold at 0.18 microM Cu(II). Toxic levels of Cd(II) did not stimulate Mn(II) oxidizing activity, indicating that Mn(II) oxidation is not a response to metal toxicity. Stimulation by Cu(II) confirms the specific role of Cu(II) in Mn(II) oxidation. Comparison of transcript levels of the multicopper oxidase mofA gene in the presence and absence of added Cu(II) do not indicate a statistically significant change in mofA transcript levels in cultures supplemented with Cu(II). Thus, the exact role of Cu(II) in Mn(II) oxidation and its affect on mofA gene expression remain uncertain. PMID:21063867

  16. Mucopolysaccharidosis type II, Hunter's syndrome.

    PubMed

    Tylki-Szymańska, Anna

    2014-09-01

    Hunter syndrome is caused by deficiency of the lysososmal enzyme iduronate-2-sulphatase that cleaves O-linked sulphate moieties from dermatan sulphate and heparan sulphate and leads to accumulation of GAGs. The disease is a X-linked condition affecting males and rarely females, clinically divided into severe (2/3) and attenuated types. Children with severe form, diagnosed at 12-36 months, have coarse facial feature, short stature, joint stiffness, short neck, broad chest, large head circumference, watery diarrhea, skeletal changes, progressive and profound mental retardation, retinal degeneration' hearing loss, cardiomyopathy, valvular involvement, with progressive thickening and stiffening of the valve leaflets leading to mitral and aortic regurgitation and stenosis . Recurrent and prolonged rhinitis with persistent nasal discharge are the first symptoms of airway disease that manifests itself as noisy breathing and later sleep apnea. Some patients develop ivory-colored skin lesions on the upper back and sides of the upper arms, pathogenomic of Hunter syndrome. The scalp hair becomes coarse, straight and bristly. Inguinal and umbilical hernias occur caused by the disturbed structure of connective tissue and increased liver and spleen volume. Patients with attenuated form have normal intelligence and a milder phenotype. Physical features diagnosed later are similar but less pronounced but progress to severe disease. Sceening is by quantitative assessment of urinary GAGs excretion. Qualitative assessment of GAG by electrophoresis can distinguish the type of mucopolysaccharidosis. Definitive diagnosis is based on enzyme activity assay in leukocytes, fibroblasts or plasma. Molecular testing is recommended mainly for genetic counseling and carrier detection. Limited experience of Haematopoietic stem cell therapy in MPS II showed progressive neurodegeneration. Recombinant 125 Idursulfase, is indicated for long-term treatment. The response appears to depend on the

  17. Mucopolysaccharidosis type II, Hunter's syndrome.

    PubMed

    Tylki-Szymańska, Anna

    2014-09-01

    Hunter syndrome is caused by deficiency of the lysososmal enzyme iduronate-2-sulphatase that cleaves O-linked sulphate moieties from dermatan sulphate and heparan sulphate and leads to accumulation of GAGs. The disease is a X-linked condition affecting males and rarely females, clinically divided into severe (2/3) and attenuated types. Children with severe form, diagnosed at 12-36 months, have coarse facial feature, short stature, joint stiffness, short neck, broad chest, large head circumference, watery diarrhea, skeletal changes, progressive and profound mental retardation, retinal degeneration' hearing loss, cardiomyopathy, valvular involvement, with progressive thickening and stiffening of the valve leaflets leading to mitral and aortic regurgitation and stenosis . Recurrent and prolonged rhinitis with persistent nasal discharge are the first symptoms of airway disease that manifests itself as noisy breathing and later sleep apnea. Some patients develop ivory-colored skin lesions on the upper back and sides of the upper arms, pathogenomic of Hunter syndrome. The scalp hair becomes coarse, straight and bristly. Inguinal and umbilical hernias occur caused by the disturbed structure of connective tissue and increased liver and spleen volume. Patients with attenuated form have normal intelligence and a milder phenotype. Physical features diagnosed later are similar but less pronounced but progress to severe disease. Sceening is by quantitative assessment of urinary GAGs excretion. Qualitative assessment of GAG by electrophoresis can distinguish the type of mucopolysaccharidosis. Definitive diagnosis is based on enzyme activity assay in leukocytes, fibroblasts or plasma. Molecular testing is recommended mainly for genetic counseling and carrier detection. Limited experience of Haematopoietic stem cell therapy in MPS II showed progressive neurodegeneration. Recombinant 125 Idursulfase, is indicated for long-term treatment. The response appears to depend on the

  18. NSLS-II Transport Line Progress

    SciTech Connect

    Fliller R. P.; Wahl, W.; Anderson, A.; Benish, B.; DeBoer, W.; Ganetis, G.; Heese, R.; Hseuh, H.-C.; Hu, J.-P.; Johanson, M.P.; Kosciuk, B.N.; Padrazo, D.; Roy, K.; Shaftan, T.; Singh, O.; Tuozzolo, J.; Wang, G.

    2012-05-20

    The National Synchrotron Light Source II (NSLS-II) is a state-of-the-art 3-GeV third generation light source currently under construction at Brookhaven National Laboratory. The NSLS-II injection system consists of a 200 MeV linac, a 3-GeV booster synchrotron and associated transfer lines. The first part of the Linac to Booster Transport (LBT) line has been installed for linac commissioning. This part includes all components necessary to commission the NSLS-II linac. The second part of this transport line is undergoing installation. Initial results of hardware commissioning will be discussed. The Booster to Storage Ring (BSR) transport line underwent a design review. The first part of the BSR transport line, consisting of all components necessary to commission the booster will be installed in 2012 for booster commissioning. We report on the final design of the BSR line along with the plan to commission the booster.

  19. Culturally and linguistically responsive teaching: part II.

    PubMed

    Billings, Diane M

    2015-03-01

    This part II of a two-part article about culturally and linguistically responsive teaching provides suggestions for evaluating learners who are culturally and linguistically diverse (CALD) and are often under-represented in nursing education settings.

  20. Zodiac II: Debris Disk Imaging Potential

    NASA Technical Reports Server (NTRS)

    Traub Wesley; Bryden, Geoff; Stapelfeldt, Karl; Chen, Pin; Trauger, John

    2011-01-01

    Zodiac II is a proposed coronagraph on a balloon-borne platform, for the purpose of observing debris disks around nearby stars. Zodiac II will have a 1.2-m diameter telescope mounted in a balloon-borne gondola capable of arcsecond quality pointing, and with the capability to make long-duration (several week) flights. Zodiac II will have a coronagraph able to make images of debris disks, meaning that its scattered light speckles will be at or below an average contrast level of about 10(exp -7) in three narrow (7 percent) bands centered on the V band, and one broad (20%) one at I band. We will discuss the potential science to be done with Zodiac II.

  1. Resistance domain in type II superconductors

    SciTech Connect

    Gurevich, A.V.; Mints, R.G.

    1980-01-05

    We show that traveling domains with a finite resistance can exist in type II superconductors in the presence of a transport current. An experiment in which this effect generates an alternating electric field and current is proposed.

  2. Far Outer Galaxy H II Regions

    NASA Technical Reports Server (NTRS)

    Rudolph, A. L.; deGues, E. J.; Brand, J.; Wouterloot, J. G. A.; Gross, Anthony R. (Technical Monitor)

    1994-01-01

    We have made a multifrequency (6, 3.6, and 2 cm), high-resolution (3"-6"), radio continuum survey of IRAS selected sources from the catalogue of Wouterloot & Brand (1989) to search for and study H II regions in the far outer Galaxy. We identified 31 sources in this catalog with well determined galactocentric distances, and with R approx.. greater than 15 kpc and L(sub FIR) approx.greater than 10(exp 4) solar luminosity, indicating the presence of high-mass star-formation. We have observed 11 of these sources with the Very Large Array (VLA). We observed the sources at 6 and 2 cm using "scaled arrays", making possible a direct and reliable comparison of the data at these two wavelengths for the determination of spectral indices. We detected a total of 12 radio sources, of which 10 have spectral indices consistent with optically-thin free-free emission from H II regions. Combined with previous VLA observations by other investigators, we have data on a total of 15 H II regions at galactocentric distances of 15 to 18.2kpc, among the most remote H II regions found in our Galaxy. The sizes of the H II regions range from approx. less than 0.10 to 2.3 pc. Using the measured fluxes and sizes, we determine the electron densities, emission measures, and excitation parameters of the H II regions, as well as the fluxes of Lyman continuum photons needed to keep the nebulae ionized. The sizes and electron densities are consistent with most of the sources detected in this survey being compact or ultracompact H II regions. Seven of the fifteen H II regions have sizes approx. less than 0.20 pc. Assuming simple pressure-driven expansion of the H II regions, these sizes indicate ages approx. less than 5 x 10(exp 4) yr, or only 1% of the lifetime of an O star, which implies an unlikely overabundance of O stars in the outer Galaxy. Thus, the large number of compact H II regions suggests that the time these regions spend in a compact phase must be much longer than their dynamical

  3. Topoisomerase II Mediates Meiotic Crossover Interference

    PubMed Central

    Zhang, Liangran; Wang, Shunxin; Yin, Shen; Hong, Soogil; Kim, Keun P.; Kleckner, Nancy

    2014-01-01

    Summary Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classical phenomenon of crossover interference. Here, analysis of crossover patterns in budding yeast identifies a molecular pathway for interference. Topoisomerase II (Topo II) plays a central role, thus identifying a new function for this critical molecule. SUMOylation [of TopoII and axis component Red1] and ubiquitin-mediated removal of SUMOylated proteins are also required. These and other findings support the hypothesis that crossover interference involves accumulation, relief and redistribution of mechanical stress along the protein/DNA meshwork of meiotic chromosome axes, with TopoII required to adjust spatial relationships among DNA segments. PMID:25043020

  4. Achondrogenesis type II, abnormalities of extracellular matrix.

    PubMed

    Horton, W A; Machado, M A; Chou, J W; Campbell, D

    1987-09-01

    Immune and lectin histochemical and microchemical methods were employed to study growth cartilage from seven cases of achondrogenesis type II (Langer-Saldino). The normal architecture of the epiphyseal and growth plate cartilage was replaced by a morphologically heterogeneous tissue. Some areas were comprised of vascular canals surrounded by extensive fibrous tissue and enlarged cells that had the appearance and histochemical characteristics of hypertrophic chondrocytes. Other areas contained a mixture of cells ranging from small to the enlarged chondrocytes. The extracellular matrix in the latter areas was more abundant and had characteristics of both precartilage mesenchymal matrix and typical cartilage matrix; it contained types I and II collagen, cartilage proteoglycan, fibronectin, and peanut agglutinin binding glycoconjugate(s). Peptide mapping of cyanogen bromide cartilage collagen peptides revealed the presence of types I and II collagen. These observations could be explained by a defect in the biosynthesis of type II collagen or in chondrocyte differentiation. PMID:3309860

  5. Achondrogenesis II-hypochondrogenesis: variability versus heterogeneity.

    PubMed

    Borochowitz, Z; Ornoy, A; Lachman, R; Rimoin, D L

    1986-06-01

    Recently hypochondrogenesis was described as a form of neonatally lethal dwarfism said to resemble spondyloepiphyseal dysplasia congenita radiographically and achondrogenesis II morphologically. Because of the difficulty in distinguishing radiographically between mild achondrogenesis II and severe hypochondrogenesis, we performed a clinical, radiographic, and morphologic study of 24 cases originally classified as either achondrogenesis II or hypochondrogenesis, in an attempt to distinguish between heterogeneity and clinical variability. Review of the radiographic findings in these cases show a fairly continuous spectrum of bony defects, rather than two distinct radiographic syndromes. Chondro-osseous histology and ultrastructure was similar in all cases regardless of severity and was characterized by hypervascularity and hypercellularity of the cartilage with multiple small, round dilated cysternae of rough endoplasmic reticulum. These findings suggest that hypochondrogenesis and achondrogenesis type II represent a spectrum with marked phenotypic variability. PMID:3717210

  6. SCORPION II persistent surveillance system update

    NASA Astrophysics Data System (ADS)

    Coster, Michael; Hunt, Cassandra

    2011-06-01

    This paper highlights the most recently added features and benefits available in the latest generation of Northrop Grumman SCORPION II persistent surveillance and target recognition systems. By leveraging smaller, lighter, and more power efficient SCORPION II sensor and universal gateway components, with foliage penetrating ad-hoc network communications, persistent field programmable systems that are easier to conceal can be optimized for both image capture and data exfiltration. In addition to the SCORPION II suite of sensor components, a growing list of over sixty different sensor and camera types from a variety of manufacturers have been integrated with the SCORPION Gateway family. In addition to updating several different COP systems, SCORPION and SCORPION II data can be directly processed using a common sensor status graphical user interface (GUI) that allows for viewing and analysis of images and sensor data from hundreds of SCORPION system gateways on single or multiple displays.

  7. PEP-II Status and Outlook

    SciTech Connect

    Wienands, H.U.; Biagini, M.E.; Decker, F.J.; Donald, M.H.; Ecklund, S.; Fisher, A.; Holtzapple, R.L.; Iverson, R.H.; Krejcik, P.; Kulikov, A.V.; Meyer, T.; Nelson, J.; Novokhatski, A.; Reichel, I.; Sullivan, M.; Seeman, J.T.; Turner, J.; Steier, C.; Zisman, M.S.; /LBL, Berkeley

    2012-04-24

    PEP-II/BABAR are presently in their second physics run. With machine and detector performance and reliability at an all-time high, almost 51 fb{sup -1} have been integrated by BABAR up to mid-October 2001. PEP-II luminosity has reached 4.4 x 10{sup 33} cm{sup -2} s{sup -1} and our highest monthly delivered luminosity has been above 6 pb{sup -1}, exceeding the performance parameters given in the PEP-II CDR by almost 50%. The increase compared to the first run in 2000 has been achieved by a combination of beam-current increase and beam-size decrease. In this paper we will summarize the PEP-II performance and the present limitations as well as our plans to further increase machine performance.

  8. Database for mobile group II introns.

    PubMed

    Dai, Lixin; Toor, Navtej; Olson, Robert; Keeping, Andrew; Zimmerly, Steven

    2003-01-01

    Group II introns are self-splicing RNAs and retroelements found in bacteria and lower eukaryotic organelles. During the past several years, they have been uncovered in surprising numbers in bacteria due to the genome sequencing projects; however, most of the newly sequenced introns are not correctly identified. We have initiated an ongoing web site database for mobile group II introns in order to provide correct information on the introns, particularly in bacteria. Information in the web site includes: (1) introductory information on group II introns; (2) detailed information on subfamilies of intron RNA structures and intron-encoded proteins; (3) a listing of identified introns with correct boundaries, RNA secondary structures and other detailed information; and (4) phylogenetic and evolutionary information. The comparative data should facilitate study of the function, spread and evolution of group II introns. The database can be accessed at http://www.fp.ucalgary.ca/group2introns/.

  9. Removal of Pb(II), Cd(II), Cu(II), and Zn(II) by hematite nanoparticles: effect of sorbent concentration, pH, temperature, and exhaustion.

    PubMed

    Shipley, Heather J; Engates, Karen E; Grover, Valerie A

    2013-03-01

    Nanoparticles offer the potential to improve environmental treatment technologies due to their unique properties. Adsorption of metal ions (Pb(II), Cd(II), Cu(II), Zn(II)) to nanohematite was examined as a function of sorbent concentration, pH, temperature, and exhaustion. Adsorption experiments were conducted with 0.05, 0.1, and 0.5 g/L nanoparticles in a pH 8 solution and in spiked San Antonio tap water. The adsorption data showed the ability of nanohematite to remove Pb, Cd, Cu, and Zn species from solution with adsorption increasing as the nanoparticle concentration increased. At 0.5 g/L nanohematite, 100 % Pb species adsorbed, 94 % Cd species adsorbed, 89 % Cu species adsorbed and 100 % Zn species adsorbed. Adsorption kinetics for all metals tested was described by a pseudo second-order rate equation with lead having the fastest rate of adsorption. The effect of temperature on adsorption showed that Pb(II), Cu(II), and Cd(II) underwent an endothermic reaction, while Zn(II) underwent an exothermic reaction. The nanoparticles were able to simultaneously remove multiple metals species (Zn, Cd, Pb, and Cu) from both a pH 8 solution and spiked San Antonio tap water. Exhaustion experiments showed that at pH 8, exhaustion did not occur for the nanoparticles but adsorption does decrease for Cd, Cu, and Zn species but not Pb species. The strong adsorption coupled with the ability to simultaneously remove multiple metal ions offers a potential remediation method for the removal of metals from water.

  10. Antenatal diagnosis of achondrogenesis type II.

    PubMed

    Kodandapani, S; Ramkumar, V

    2009-01-01

    Achondrogenesis is a lethal congenital chondrodystrophy characterized by extreme micromelia, small thorax and polyhydramnios. We describe a case of achondrogenesis type II (Langer-Saldino achondrogenesis). Prenatal ultrasonography at 22-weeks gestation revealed a fetus with large head, short neck and chest, prominent abdomen and short limbs. Pregnancy was terminated. Radiologic examination of neonate revealed features of achondrogenesis type II. Routine ultrasound screening made early detection and timely management possible. PMID:20387359

  11. EXODUS II: A finite element data model

    SciTech Connect

    Schoof, L.A.; Yarberry, V.R.

    1994-09-01

    EXODUS II is a model developed to store and retrieve data for finite element analyses. It is used for preprocessing (problem definition), postprocessing (results visualization), as well as code to code data transfer. An EXODUS II data file is a random access, machine independent, binary file that is written and read via C, C++, or Fortran library routines which comprise the Application Programming Interface (API).

  12. The Ssart of Run II at CDF

    SciTech Connect

    Marco Rescigno

    2002-10-29

    After a hiatus of almost 6 years and an extensive upgrade, Tevatron, the world largest proton-antiproton collider, has resumed the operation for the so called RUN II. In this paper we give a brief overview of the many new features of the Tevatron complex and of the upgraded CDF experiment, and show the presently achieved detector performances as well as highlights of the RUN II physics program in the beauty and electroweak sector.

  13. NSLS-II Radio Frequency Systems

    SciTech Connect

    Rose J.; Gao F.; Goel, A.; Holub, B.; Kulpin, J.; Marques, C.; Yeddulla, M.

    2015-05-03

    The National Synchrotron Light Source II is a 3 GeV X-ray user facility commissioned in 2014. The NSLS-II RF system consists of the master oscillator, digital low level RF controllers, linac, booster and storage ring RF sub-systems, as well as a supporting cryogenic system. Here we will report on RF commissioning and early operation experience of the system.

  14. NSLS-II Beam Diagnostics Overview

    SciTech Connect

    Singh,O.; Alforque, R.; Bacha, B.; Blednykh, A.; Cameron, P.; Cheng, W.; Dalesio, L. B.; Della Penna, A. J.; doom, L.; Fliller, R. P.; Ganetis, G.; Heese, R.; Hseuh, H-C.; Johnson, E. D.; Kosciuk, b. N.; Kramer, S. L.; Krinsky, S.; Mead, J.; Ozaki, S.; Padrazo, D.; Pinayev, I.; Ravindranath, R. V.; Rose, J.; Shaftan, T.; Sharma, S.; Skaritka, J.; Tanabe, T.; Tian, Y.; Willeke, F. J.; Yu, L-H.

    2009-05-04

    A new 3rd generation light source (NSLS-II) is in the early stages of construction at Brookhaven National Laboratory. The NSLS-II facility will provide ultra high brightness and flux with exceptional beam stability. It presents several challenges for diagnostics and instrumentation, related to the extremely small emittance. In this paper, we present an overview of all planned instrumentation systems, results from research and development activities; and then focus on other challenging aspects.

  15. Performance of dipole magnets in helium II

    SciTech Connect

    Althaus, R.; Caspi, S.; Gilbert, W.S.; Hassenzahl, W.; Meuser, R.; Rechen, J.; Taylor, C.; Warren, R.

    1981-03-01

    Data from tests in He II of four 1-meter-long magnets are presented. The maximum quench current is increased up to 30 percent, compared with tests in He I. Data from calorimetric measurements of heat generated during cyclic operation are presented. Quenches were induced by heaters placed near the conductor, and the energy required to induce quenches in He II and in He I are compared.

  16. Synthesis and characterization of hydroxyapatite nanoparticles impregnated on apple pomace to enhanced adsorption of Pb(II), Cd(II), and Ni(II) ions from aqueous solution.

    PubMed

    Chand, Piar; Pakade, Yogesh B

    2015-07-01

    Hydroxyapatite nanoparticles were synthesized, characterized, and impregnated onto apple pomace surface (HANP@AP) for efficient removal of Pb(II), Cd(II), and Ni(II) ions from water. HANP@AP was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), transmission electron microscope (TEM), X-ray diffraction (XRD), and surface area analysis. Batch sorption studies were carried out to investigate the influence of different parameters as amount of dose (g), pH, time (min), and initial concentration (mg L(-1)) on adsorption process. Experimental kinetic data followed pseudo-second-order model and equilibrium data well fitted to Langmuir adsorption model with maximum adsorption capacities of 303, 250, and 100 mg g(-1) for Pb(II), Cd(II), and Ni(II) ions, respectively. Competitive adsorption of Pb(II), Cd(II), and Ni(II) ions in presences of each other was studied to evaluate the removal efficiency of HANP@AP against multi metal-loaded water. HANP@AP was successfully applied to real industrial wastewater with 100 % removal of all three metal ions even at high concentration. HANP@AP could be recycled for four, four, and three cycles in case of Pb(II), Cd(II) and Ni(II), respectively. The study showed that HANP@AP is fast, cost effective, and environmental friendly adsorbent for removal of Pb(II), Cd(II), and Ni(II) ions from real industrial wastewater.

  17. Pb(II) and Cd(II) removal from aqueous solutions by olive cake.

    PubMed

    Doyurum, Sabriye; Celik, Ali

    2006-11-01

    The removal of heavy metals from wastewater using olive cake as an adsorbent was investigated. The effect of the contact time, pH, temperature, and concentration of adsorbate on adsorption performance of olive cake for Pb(II) and Cd(II) ions were examined by batch method. Adsorption of Pb(II) and Cd(II) in aqueous solution onto olive cake was studied in single component. After establishing the optimum conditions, elution of these ions from the adsorbent surface was also examined. The optimum sorption conditions were determined for two elements. Maximum desorption of the Pb(II) and Cd(II) ions were found to be 95.92 and 53.97% by 0.5M HNO(3) and 0.2M HCl, respectively. The morphological analysis of the olive cake was performed by the scanning electron microscopy (SEM). PMID:16806680

  18. Preferred crystallographic orientation in the ice I ← II transformation and the flow of ice II

    USGS Publications Warehouse

    Bennett, K.; Wenk, H.-R.; Durham, W.B.; Stern, L.A.; Kirby, S.H.

    1997-01-01

    The preferred crystallographic orientation developed during the ice I ← II transformation and during the plastic flow of ice II was measured in polycrystalline deuterium oxide (D2O) specimens using low-temperature neutron diffraction. Samples partially transformed from ice I to II under a non-hydrostatic stress developed a preferred crystallographic orientation in the ice II. Samples of pure ice II transformed from ice I under a hydrostatic stress and then when compressed axially, developed a strong preferred orientation of compression axes parallel to (1010). A match to the observed preferred orientation using the viscoplastic self-consistent theory was obtained only when (1010) [0001] was taken as the predominant slip system in ice II.

  19. PIVKA-II-producing advanced gastric cancer.

    PubMed

    Takano, Shigetsugu; Honda, Ichiro; Watanabe, Satoshi; Soda, Hiroaki; Nagata, Matsuo; Hoshino, Isamu; Takenouchi, Toshinao; Miyazaki, Masaru

    2004-08-01

    We describe the case of a 68-year-old man with primary advanced adenocarcinoma of the stomach, who displayed extremely high plasma levels of protein induced by vitamin K antagonist (PIVKA)-II (15 600 mAU/ml) and normal levels of alphafetoprotein (AFP) (4 ng/ml). Ultrasonography and dynamic computed tomography ruled out hepatocellular carcinoma (HCC) or liver metastasis. After preoperative chemotherapy, pancreatico-spleno total gastrectomy with D2 lymphadenectomy was performed. Postoperatively, plasma levels of PIVKA-II returned to within the normal range (29 mAU/ml). Microscopic examination revealed stomach adenocarcinoma showing various histological types, such as moderately to poorly differentiated mucinous adenocarcinoma, but hepatoid differentiation of gastric adenocarcinoma was not detected. Localization of PIVKA-II and AFP within tumor cells was demonstrated by immunohistochemical staining using monoclonal antibodies. These results indicate that tumor cells from gastric cancer may produce PIVKA-II. Some cases of PIVKA-II- and AFP-producing advanced gastric cancer with liver metastasis have been reported, but this is the first report of gastric cancer without liver metastasis producing PIVKA-II alone.

  20. Group II Introns and Their Protein Collaborators

    NASA Astrophysics Data System (ADS)

    Solem, Amanda; Zingler, Nora; Pyle, Anna Marie; Li-Pook-Than, Jennifer

    Group II introns are an abundant class of autocatalytic introns that excise themselves from precursor mRNAs. Although group II introns are catalytic RNAs, they require the assistance of proteins for efficient splicing in vivo. Proteins that facilitate splicing of organellar group II introns fall into two main categories: intron-encoded maturases and host-encoded proteins. This chapter will focus on the host proteins that group II introns recruited to ensure their function. It will discuss the great diversity of these proteins, define common features, and describe different strategies employed to achieve specificity. Special emphasis will be placed on DEAD-box ATPases, currently the best studied example of host-encoded proteins with a role in group II intron splicing. Since the exact mechanisms by which splicing is facilitated is not known for any of the host proteins, general mechanistic strategies for protein-mediated RNA folding are described and assessed for their potential role in group II intron splicing.

  1. Calcitonin metabolism in senile (type II) osteoporosis.

    PubMed

    Reginster, J Y; Deroisy, R; Bruwier, M; Franchimont, P

    1992-05-01

    The exact role of calcitonin (CT) in the pathogenesis of senile (Type II) osteoporosis remains unknown. Whole plasma calcitonin (iCT) and extracted monomeric calcitonin (eCT) basal levels, metabolic clearance rate (MCR) and production rate (PR) of iCT and eCT were measured in 41 postmenopausal women, including 14 hip fractures (OP II) and 27 healthy controls. No significant difference appeared for basal iCT levels between OP II (mean +/- SEM: 41.9 +/- 3.4 pg/ml) and controls (mean +/- SEM: 46.2 +/- 5 pg/ml). eCT basal levels were similar in OP II (mean +/- SEM: 5.42 +/- 0.5 pg/ml) and in controls (mean +/- SEM: 7.3 +/- 0.7 pg/ml). MCR were similar in the two groups. iCT PR were similar in OP II (mean +/- SEM: 17.2 +/- 1.5 micrograms/24 h) and controls (mean +/- SEM: 18.6 +/- 1.1 micrograms/24 h). No difference appeared between eCT PR in OP II (mean +/- SEM: 2.3 +/- 0.2 micrograms/24 h) and controls (mean +/- SEM: 3.2 +/- 0.3 pg/ml). From these data, no evidence appears that calcitonin might be one of the determinant factors in the pathogenesis of senile osteoporosis.

  2. AUGO II: A Comprehensive Subauroral Zone Observatory

    NASA Astrophysics Data System (ADS)

    Schofield, I. S.; Connors, M. G.

    2012-12-01

    Athabasca University Geophysical Observatory II (AUGO II) is a comprehensive subauroral zone observatory designed for routine automated optical and magnetic observation of the aurora. Becoming operational in February 2012, AUGO II has six temperature/humidity controlled observation rooms, each equipped with a 1.5 meter diameter acrylic dome custom fabricated for wide spectral transparency. AUGO II is located approximately 25 km southwest of the town of Athabasca, in Alberta, Canada, on the southern edge of the auroral zone (Geodetic coordinates: latitude 54 36' 10", longitude 113 38' 40" west. CGM coordinates: latitude 61.7, longitude 306.8, L-value 4.5). AUGO II is sufficiently isolated from urban development that skies are dark enough during winter months to allow optical studies of faint phenomena, such as H-beta studies of proton precipitation aurora, currently underway. The observatory's modest residence can accommodate six persons, allowing groups to live and work with their instruments for the duration of their research campaign without leaving the site. AUGO II's inaugural guest research campaign was reported successful, and resulted in a permanent VLF/LF radio experiment being deployed at the observatory's expansive site. We are hopeful more research groups will take advantage of this unique facility and help realize its full potential.

  3. Designing a Cu(II)-ArCu(II)-ArCu(III)-Cu(I) catalytic cycle: Cu(II)-catalyzed oxidative arene C-H bond azidation with air as an oxidant under ambient conditions.

    PubMed

    Yao, Bo; Liu, Yang; Zhao, Liang; Wang, De-Xian; Wang, Mei-Xiang

    2014-11-21

    On the basis of our recent discovery of high valent organocopper compounds, we have designed and achieved efficient copper(II)-catalyzed oxidative arene C-H bond azidation under very mild aerobic conditions by using NaN3 as an azide source. In the presence of a Cu(II) catalyst, a number of azacalix[1]arene[3]pyridines underwent direct arene C-H bond cupration through an electrophilic aromatic metalation pathway to form an arylcopper(II) intermediate. Oxidized by a free copper(II) ion, the arylcopper(II) intermediate was transformed into an arylcopper(III) species that subsequently cross-coupled with azide to furnish the formation of aryl azide products with the release of a copper(I) ion. Under ambient catalytic reaction conditions, the copper(I) species generated was oxidized by air into copper(II), which entered into the next catalytic cycle. Application of the method was demonstrated by the synthesis of functional azacalix[1]arene[3]pyridines by means of simple and practical functional group transformations of azide. The showcase of the Cu(II)-ArCu(II)-ArCu(III)-Cu(I) catalytic cycle would provide a new strategy for the design of copper(II)-catalyzed aerobic oxidative arene C-H bond activation and transformations.

  4. Designing a Cu(II)-ArCu(II)-ArCu(III)-Cu(I) catalytic cycle: Cu(II)-catalyzed oxidative arene C-H bond azidation with air as an oxidant under ambient conditions.

    PubMed

    Yao, Bo; Liu, Yang; Zhao, Liang; Wang, De-Xian; Wang, Mei-Xiang

    2014-11-21

    On the basis of our recent discovery of high valent organocopper compounds, we have designed and achieved efficient copper(II)-catalyzed oxidative arene C-H bond azidation under very mild aerobic conditions by using NaN3 as an azide source. In the presence of a Cu(II) catalyst, a number of azacalix[1]arene[3]pyridines underwent direct arene C-H bond cupration through an electrophilic aromatic metalation pathway to form an arylcopper(II) intermediate. Oxidized by a free copper(II) ion, the arylcopper(II) intermediate was transformed into an arylcopper(III) species that subsequently cross-coupled with azide to furnish the formation of aryl azide products with the release of a copper(I) ion. Under ambient catalytic reaction conditions, the copper(I) species generated was oxidized by air into copper(II), which entered into the next catalytic cycle. Application of the method was demonstrated by the synthesis of functional azacalix[1]arene[3]pyridines by means of simple and practical functional group transformations of azide. The showcase of the Cu(II)-ArCu(II)-ArCu(III)-Cu(I) catalytic cycle would provide a new strategy for the design of copper(II)-catalyzed aerobic oxidative arene C-H bond activation and transformations. PMID:25350606

  5. Coronal type II bursts and interplanetary type II bursts: Distinct shock drivers

    NASA Astrophysics Data System (ADS)

    Suryanarayana, G. S.

    2012-02-01

    We study solar radio type II bursts combining with Wind/WAVES type II bursts and coronal mass ejections (CMEs). The aim of the present work is to investigate the effectiveness of shocks to cause type II bursts in the solar corona and the interplanetary space. We consider the following findings. The distribution of the cessation heights of type II emission is confined to a rather narrow range of height than the distribution of the heights of start frequencies. This is suggestive of the presence of a gradient for the Alfvén speed from the heliocentric height of ˜1.4 solar radii. The range of the kinetic energy of CMEs associated with coronal type II emission taken together with the suggested computation method and the Alfvén speed gradient, indicates the limit to the height up to which type II emission could be expected. This height is ˜2 solar radii from the center of the Sun. Further, the large time gap between the cessation time and heights of coronal type II emission and the commencement time and heights of most of the IP type II bursts do not account for the difference between the two heights and the average shock speed. Also, there is clear difference in the magnitude of the kinetic energies and the distinct characteristics of the CMEs associated with coronal and IP type II bursts. Hence, we suggest that in most instances the coronal type II bursts and IP type II bursts occur due to distinct shocks. We also address the question of the origin of type II bursts and discuss the possible explanation of observed results.

  6. 40 CFR Table 1 to Subpart II of... - General Provisions of Applicability to Subpart II

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Reference Applies to subpart II Comment 63.1(a)(1)-(3) Yes. 63.1(a)(4) Yes Subpart II clarifies the applicability of each paragraph in subpart A to sources subject to subpart II. 63.1(a)(5)-(7) Yes 63.1(a)(8) No Discusses State programs. 63.1(a)(9)-(14) Yes 63.1(b)(1) Yes § 63.781 specifies applicability in more...

  7. Competitive sorption of Pb(II), Cu(II) and Ni(II) on carbonaceous nanofibers: A spectroscopic and modeling approach.

    PubMed

    Ding, Congcong; Cheng, Wencai; Wang, Xiangxue; Wu, Zhen-Yu; Sun, Yubing; Chen, Changlun; Wang, Xiangke; Yu, Shu-Hong

    2016-08-01

    The competitive sorption of Pb(II), Cu(II) and Ni(II) on the uniform carbonaceous nanofibers (CNFs) was investigated in binary/ternary-metal systems. The pH-dependent sorption of Pb(II), Cu(II) and Ni(II) on CNFs was independent of ionic strength, indicating that inner-sphere surface complexation dominated sorption Pb(II), Cu(II) and Ni(II) on CNFs. The maximum sorption capacities of Pb(II), Cu(II) and Ni(II) on CNFs in single-metal systems at a pH 5.5±0.2 and 25±1°C were 3.84 (795.65mg/g), 3.21 (204.00mg/g) and 2.67 (156.70mg/g)mmol/g, respectively. In equimolar binary/ternary-metal systems, Pb(II) exhibited greater inhibition of the sorption of Cu(II) and Ni(II), demonstrating the stronger affinity of CNFs for Pb(II). The competitive sorption of heavy metals in ternary-metal systems was predicted quite well by surface complexation modeling derived from single-metal data. According to FTIR, XPS and EXAFS analyses, Pb(II), Cu(II) and Ni(II) were specifically adsorbed on CNFs via covalent bonding. These observations should provide an essential start in simultaneous removal of multiple heavy metals from aquatic environments by CNFs, and open the doorways for the application of CNFs. PMID:27108273

  8. Circulating angiotensin II deteriorates left ventricular function with sympathoexcitation via brain angiotensin II receptor

    PubMed Central

    Shinohara, Keisuke; Kishi, Takuya; Hirooka, Yoshitaka; Sunagawa, Kenji

    2015-01-01

    Sympathoexcitation contributes to the progression of heart failure. Activation of brain angiotensin II type 1 receptors (AT1R) causes central sympathoexcitation. Thus, we assessed the hypothesis that the increase in circulating angiotensin II comparable to that reported in heart failure model affects cardiac function through the central sympathoexcitation via activating AT1R in the brain. In Sprague-Dawley rats, the subcutaneous infusion of angiotensin II for 14 days increased the circulating angiotensin II level comparable to that reported in heart failure model rats after myocardial infarction. In comparison with the control, angiotensin II infusion increased 24 hours urinary norepinephrine excretion, and systolic blood pressure. Angiotensin II infusion hypertrophied left ventricular (LV) without changing chamber dimensions while increased end-diastolic pressure. The LV pressure–volume relationship indicated that angiotensin II did not impact on the end-systolic elastance, whereas significantly increased end-diastolic elastance. Chronic intracerebroventricular infusion of AT1R blocker, losartan, attenuated these angiotensin II-induced changes. In conclusion, circulating angiotensin II in heart failure is capable of inducing sympathoexcitation via in part AT1R in the brain, subsequently leading to LV diastolic dysfunction. PMID:26290529

  9. Synthesis, spectroscopic studies and crystal structure of the Schiff base ligand L derived from condensation of 2-thiophenecarboxaldehyde and 3,3'-diaminobenzidine and its complexes with Co(II), Ni(II), Cu(II), Cd(II) and Hg(II): Comparative DNA binding studies of L and its Co(II), Ni(II) and Cu(II) complexes

    NASA Astrophysics Data System (ADS)

    Shakir, Mohammad; Abbasi, Ambreen; Azam, Mohammad; Khan, Asad U.

    2011-09-01

    The Schiff base ligand, N,N'-bis-(2-thiophenecarboxaldimine)-3,3'-diaminobenzidine (L) obtained from condensation of 2-thiophenecarboxaldehyde and 3,3'-diaminobenzidine, was used to synthesize the complexes of type, [M 2L 2]Cl 4 [M = Co(II), Ni(II), Cu(II), Cd(II) and Hg(II)]. The newly synthesized ligand (L) was characterized on the basis of the results of elemental analysis, FT-IR, 1H NMR, 13C NMR, mass spectroscopic studies and single crystal X-ray crystallography. The characteristic resonance signals in 1H NMR and 13C NMR spectra indicated the presence of azomethine group as a result of condensation reaction. The stoichiometry, bonding and stereochemistries of complexes were ascertained on the basis of results of elemental analysis, magnetic susceptibility measurements, molar conductance and spectroscopic studies viz., FT-IR, 1H and 13C NMR, UV-vis and EPR. EPR, UV-vis and magnetic moment data revealed an octahedral geometry for complexes with distortion in Cu(II) complex and conductivity data show 1:2 electrolytic nature of complexes. Absoption and fluorescence spectroscopic studies supported that Schiff base ligand L and its Co(II), Ni(II) and Cu(II) complexes exhibited significant binding to calf thymus DNA. The complexes exhibited higher affinity to calf thymus DNA than the free Schiff base ligand L.

  10. STELLAR POPULATIONS AND THE STAR FORMATION HISTORIES OF LOW SURFACE BRIGHTNESS GALAXIES. II. H II REGIONS

    SciTech Connect

    Schombert, James; McGaugh, Stacy; Maciel, Tamela E-mail: stacy.mcgaugh@case.edu

    2013-08-01

    The luminosities, colors, and H{alpha} emission for 429 H II regions in 54 low surface brightness (LSB) galaxies are presented. While the number of H II regions per galaxy is lower in LSB galaxies compared to star-forming irregulars and spirals, there is no indication that the size or luminosity function of H II regions differs from other galaxy types. The lower number of H II regions per galaxy is consistent with their lower total star formation rates. The fraction of the total L{sub H{alpha}} contributed by H II regions varies from 10% to 90% in LSB galaxies (the rest of the H{alpha} emission being associated with a diffuse component) with no correlation with galaxy stellar or gas mass. Bright H II regions have bluer colors, similar to the trend in spirals; their number and luminosities are consistent with the hypothesis that they are produced by the same H II luminosity function as spirals. Comparison with stellar population models indicates that the brightest H II regions in LSB galaxies range in cluster mass from a few 10{sup 3} M{sub Sun} (e.g., {rho} Oph) to globular-cluster-sized systems (e.g., 30 Dor) and that their ages are consistent with clusters from 2 to 15 Myr old. The faintest H II regions are comparable to those in the LMC powered by a single O or B star. Thus, star formation in LSB galaxies covers the full range of stellar cluster mass.

  11. Cu(II) and Zn(II) adsorption capacity of three different clay liner materials.

    PubMed

    Musso, T B; Parolo, M E; Pettinari, G; Francisca, F M

    2014-12-15

    Sorption of Cu(II) and Zn(II) on three natural clays meeting the international requirements for use as liners was evaluated by means of batch tests. The purpose of this research was to determine the retention capacities of the clays for metal cations commonly present in urban solid waste leachates. The pH and ionic strength conditions were set at values frequently found in real leachates. The changes observed in the XRD patterns and FTIR spectra upon adsorption can be considered an evidence of clay-metal electrostatic interaction. The Langmuir model was found to best describe the sorption processes, offering maximum sorption capacities from 8.16 to 56.89 mg/g for Cu(II) and from 49.59 to 103.83 mg/g for Zn(II). All samples remove more Zn(II) than Cu(II), which may be related to the different geometry of the hydrated Cu(II) cation. The total amount of metal sorption was strongly influenced by the total specific surface area, the presence of carbonates and the smectite content of the clays. In addition to their known quality as physical barriers, the adsorbed amounts obtained indicate the suitability of the tested clays to contribute to the retardation of Cu(II) and Zn(II) transport through clay liners.

  12. Phosphate effects on copper(II) and lead(II) sorption to ferrihydrite

    NASA Astrophysics Data System (ADS)

    Tiberg, Charlotta; Sjöstedt, Carin; Persson, Ingmar; Gustafsson, Jon Petter

    2013-11-01

    Transport of lead(II) and copper(II) ions in soil is affected by the soil phosphorus status. Part of the explanation may be that phosphate increases the adsorption of copper(II) and lead(II) to iron (hydr)oxides in soil, but the details of these interactions are poorly known. Knowledge about such mechanisms is important, for example, in risk assessments of contaminated sites and development of remediation methods. We used a combination of batch experiments, extended X-ray absorption fine structure (EXAFS) spectroscopy and surface complexation modeling with the three-plane CD-MUSIC model to study the effect of phosphate on sorption of copper(II) and lead(II) to ferrihydrite. The aim was to identify the surface complexes formed and to derive constants for the surface complexation reactions. In the batch experiments phosphate greatly enhanced the adsorption of copper(II) and lead(II) to ferrihydrite at pH < 6. The largest effects were seen for lead(II).

  13. Studies on Pt{sub x}Sn{sub y} bimetallics in NaY. II. Further characterization and catalytic properties in the dehydrogenation and hydrogenolysis of propane

    SciTech Connect

    Meriaudeau, P.; Thangaraj, A.; Dutel, J.F.; Naccache, C.

    1997-04-01

    CO adsorption and desorption, as studied by IR spectroscopy and mass spectrometry has been used to characterize PtNaY and Pt{sub x}Sn{sub y}NaY samples. The change observed between adsorbed CO spectra and CO TPD has been attributed to an increase of the particle sizes due to the addition of Sn to Pt. The catalytic properties of these materials were studied by using propane dehydrogenation and propane hydrogenolysis. The TOF of propene formation is nearly the same for all samples and the apparent activation energy remains unchanged, indicating that no change in the Pt dehydrogenation properties is induced by adding Sn. In contrast the hydrogenolysis properties are deeply depressed by alloying Pt to Sn, these changes being attributed to a dilution effect rather than to an electronic effect. 20 refs., 9 figs., 2 tabs.

  14. Thermotropic ionic liquid crystals. II. 1H and 23Na NMR study of the smectic mesophase of molten sodium n-butyrate and sodium isovalerate

    NASA Astrophysics Data System (ADS)

    Bonekamp, J. E.; Eguchi, T.; Plesko, S.; Jonas, J.

    1983-08-01

    The 1H and 23Na NMR studies of smectic ionic mesophases of molten sodium n-butyrate and sodium isovalerate are reported over the temperature range of the stability of the liquid crystalline phases. The 1H spin-lattice relaxation times T1 at ν0=9.2, 24.3, and 60 MHz for the anions of both the systems are interpreted in terms of diffusion intermolecular relaxation mechanism. The predicted anion diffusion coefficients are in agreement with those measured directly by spin-echo technique and indicate that the anion diffuses rapidly. In contrast to the T1 relaxation mechanism the results obtained for the proton relaxation times in the rotating coordinate frame T1ρ indicate that the order-fluctuation relaxation mechanism determines the frequency dispersion of T1ρ. The analysis of the T1ρ data provides an approximate measure of the order parameter S as a function of temperature. Fourier transform spectra of the 23Na transitions show that the electric field gradient (EFG) at the Na+ ion is nonaveraged and of such a strength as to produce a second order quadrupole effect in the spectra of the central transition. From the first-order splitting, the quadrupole coupling constant (QCC) is obtained as a function of temperature. The gradual temperature change of QCC demonstrates that only a single liquid crystalline phase exists over the temperature interval of the stability of the smectic mesophase. Using approximate analysis the correlation time τc for the EFG fluctuation is obtained from the 23Na T1 data for the melts of both sodium n-butyrate and sodium isovalerate.

  15. Modeling Topaz-II system performance

    SciTech Connect

    Lee, H.H.; Klein, A.C. )

    1993-01-01

    The US acquisition of the Topaz-11 in-core thermionic space reactor test system from Russia provides a good opportunity to perform a comparison of the Russian reported data and the results from computer codes such as MCNP (Ref. 3) and TFEHX (Ref. 4). The comparison study includes both neutronic and thermionic performance analyses. The Topaz II thermionic reactor is modeled with MCNP using actual Russian dimensions and parameters. The computation of the neutronic performance considers several important aspects such as the fuel enrichment and location of the thermionic fuel elements (TFES) in the reactor core. The neutronic analysis included the calculation of both radial and axial power distribution, which are then used in the TFEHX code for electrical performance. The reactor modeled consists of 37 single-cell TFEs distributed in a 13-cm-radius zirconium hydride block surrounded by 8 cm of beryllium metal reflector. The TFEs use 90% enriched [sup 235]U and molybdenum coated with a thin layer of [sup 184]W for emitter surface. Electrons emitted are captured by a collector surface with a gap filled with cesium vapor between the collector and emitter surfaces. The collector surface is electrically insulated with alumina. Liquid NaK provides the cooling system for the TFEs. The axial thermal power distribution is obtained by dividing the TFE into 40 axial nodes. Comparison of the true axial power distribution with that produced by electrical heaters was also performed.

  16. Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation.

    PubMed

    Takahashi, S; Nakano, T; Koiwa, T; Noshita, T; Funayama, S; Koshino, H; Nakagawa, A

    2000-02-01

    Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing alpha-D-galactose by various NMR spectral analyses and chemical degradation. PMID:10805577

  17. Angiotensin II: role in skeletal muscle atrophy.

    PubMed

    Cabello-Verrugio, Claudio; Córdova, Gonzalo; Salas, José Diego

    2012-09-01

    Skeletal muscle, the main protein reservoir in the body, is a tissue that exhibits high plasticity when exposed to changes. Muscle proteins can be mobilized into free amino acids when skeletal muscle wasting occurs, a process called skeletal muscle atrophy. This wasting is an important systemic or local manifestation under disuse conditions (e.g., bed rest or immobilization), in starvation, in older adults, and in several diseases. The molecular mechanisms involved in muscle wasting imply the activation of specific signaling pathways which ultimately manage muscle responses to modulate biological events such as increases in protein catabolism, oxidative stress, and cell death by apoptosis. Many factors have been involved in the generation and maintenance of atrophy in skeletal muscle, among them angiotensin II (Ang-II), the main peptide of renin-angiotensin system (RAS). Together with Ang-II, the angiotensin-converting enzyme (ACE) and the Ang-II receptor type 1 (AT-1 receptor) are expressed in skeletal muscle, forming an important local axis that can regulate its function. In many of the conditions that lead to muscle wasting, there is an impairment of RAS in a global or local fashion. At this point, there are several pieces of evidence that suggest the participation of Ang-II, ACE, and AT-1 receptor in the generation of skeletal muscle atrophy. Interestingly, the Ang-II participation in muscle atrophy is strongly ligated to the regulation of hypertrophic activity of factors such as insulin-like growth factor 1 (IGF-1). In this article, we reviewed the current state of Ang-II and RAS function on skeletal muscle wasting and its possible use as a therapeutic target to improve skeletal muscle function under atrophic conditions.

  18. Luminescence of the elpasolite series M{sup I}{sub 2}M{sup II}MCl{sub 6} (M{sup I}=Cs, Rb; M{sup II}=Li, Na; M=Lu, Y, Sc, In) doped with europium using synchrotron radiation excitation

    SciTech Connect

    Tanner, Peter A.; Duan Changkui; Jia Guohua; Cheng, Bing-Ming

    2012-04-15

    The excitation and emission spectra of a series of cubic hexachloroelpasolites doped with europium have been investigated using synchrotron radiation at 10 K. Besides the Eu{sup 3+} emission from {sup 5}D{sub J} (J=0-3) multiplets, emission from {sup 5}H{sub 3} is also observed for Cs{sub 2}NaIn{sub 0.995}Eu{sub 0.005}Cl{sub 6}, since the gap to the next lowest level is spanned by seven phonons. The excitation spectra of samples indicate impurities due to oxygen and divalent europium. Broad band emission from Eu{sup 2+} is reported from the crystalline samples grown in vacuum by the Bridgman process, with the maximum wavelength shifting to the red with increasing lattice parameter for the series Cs{sub 2}NaMCl{sub 6}:Eu{sup 2+} (M=Lu, Y, Eu). - Graphical abstract: Luminescence of Eu{sup 3+} and Eu{sup 2+} in elpasolite hosts under synchrotron radiation is observed and assigned. Highlights: Black-Right-Pointing-Pointer Synthesis of M{sup I}{sub 2}M{sup II}MCl{sub 6}-doped with europium. Black-Right-Pointing-Pointer 10 K spectra indicate broad bands due to Eu-O CT, Eu-Cl CT and Eu{sup 2+} transitions. Black-Right-Pointing-Pointer Ultraviolet emission from the {sup 3}H{sub 5} level of Eu{sup 3+}, not only restricted to fluorides. Black-Right-Pointing-Pointer Correlation between Eu{sup 2+} emission maximum and host lattice parameter.

  19. Spectroscopic evaluation of Co(II), Ni(II) and Cu(II) complexes derived from thiosemicarbazone and semicarbazone

    NASA Astrophysics Data System (ADS)

    Chandra, Sulekh; Kumar, Anil

    2007-12-01

    Co(II), Ni(II) and Cu(II) complexes were synthesized with thiosemicarbazone (L 1) and semicarbazone (L 2) derived from 2-acetyl furan. These complexes were characterized by elemental analysis, molar conductance, magnetic moment, mass, IR, electronic and EPR spectral studies. The molar conductance measurement of the complexes in DMSO corresponds to non-electrolytic nature. All the complexes are of high-spin type. On the basis of different spectral studies six coordinated geometry may be assigned for all the complexes except Co(L) 2(SO 4) and Cu(L) 2(SO 4) [where L = L 1 and L 2] which are of five coordinated square pyramidal geometry.

  20. Statistics of equivalent width data and new oscillator strengths for Si II, Fe II, and Mn II. [in interstellar medium

    NASA Technical Reports Server (NTRS)

    Van Buren, Dave

    1986-01-01

    Equivalent width data from Copernicus and IUE appear to have an exponential, rather than a Gaussian distribution of errors. This is probably because there is one dominant source of error: the assignment of the background continuum shape. The maximum likelihood method of parameter estimation is presented for the case of exponential statistics, in enough generality for application to many problems. The method is applied to global fitting of Si II, Fe II, and Mn II oscillator strengths and interstellar gas parameters along many lines of sight. The new values agree in general with previous determinations but are usually much more tightly constrained. Finally, it is shown that care must be taken in deriving acceptable regions of parameter space because the probability contours are not generally ellipses whose axes are parallel to the coordinate axes.

  1. Heterotrimetallic Ru(II)/Pd(II)/Ru(II) complexes: synthesis, crystalstructure, spectral characterization, DFT calculation and antimicrobial study.

    PubMed

    Al-Noaimi, Mousa; Nafady, Ayman; Warad, Ismail; Alshwafy, Rwaida; Husein, Ahmad; Talib, Wamidh H; Hadda, Taibi Ben

    2014-03-25

    New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)2(η(3)-triamine)]Cl (5) (triemine=N(1)-(2-aminoethyl)-1,2-ethanediamine) have been synthesized by reacting [RuCl2(PPh3)3] (1) with one mole equivalent of N(1)-(2-aminoethyl)-1,2-ethanediamine in dichloromethane. Reaction of (2) with half-equivalent of (PhCN)2PdCl2 or Pd(OAc)2 in dichloromethane as a solvent afforded two novel heterotrimetallic Ru(II)-Pd(II)-Ru(II) complexes, [Ru(II)Cl2(PPh3)2(triamine)]2[Pd(II)X2](X=Cl, OAc) (3 and 4), bearing bioactive ligand. The progress of the undertaken reactions was monitored by (31)P{1H} NMR and FTIR. Crystal structure of complex 2 was confirmed by X-ray diffraction. The absorption spectrum of 2 in dichloromethane was modeled by time-dependent density functional theory (TD-DFT). The in vitro antimicrobial studies of complex 2-5 against an array of microorganisms (bacteria and fungi) were conducted. Complexes 3 and 4 exhibit high dual antibacterial and antifungal activity inhibiting microorganisms possibly via hydrolytic pathway which further evidenced by electrochemical analyses. The complexes 3 and 4 show a high inhibitory activity at 200 μg/ml concentration, suggesting that complexes 3 and 4 are two efficient catalytic inhibitor of microorganisms and further, they should be tested against cancer strains.

  2. 40 CFR Appendix II to Subpart E of... - Sampling Tables

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Sampling Tables II Appendix II to Subpart E of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE..., Subpt. E, App. II Appendix II to Subpart E of Part 205—Sampling Tables Table 1—Model Year...

  3. 40 CFR Appendix II to Subpart E of... - Sampling Tables

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Sampling Tables II Appendix II to Subpart E of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE..., Subpt. E, App. II Appendix II to Subpart E of Part 205—Sampling Tables Table 1—Model Year...

  4. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used...

  5. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used...

  6. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used...

  7. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used...

  8. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used...

  9. 49 CFR 238.317 - Class II brake test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Class II brake test. 238.317 Section 238.317... Requirements for Tier I Passenger Equipment § 238.317 Class II brake test. (a) A Class II brake test shall be.... In these circumstances, a Class II brake test shall be performed prior to the train's departure...

  10. 49 CFR 238.317 - Class II brake test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Class II brake test. 238.317 Section 238.317... Requirements for Tier I Passenger Equipment § 238.317 Class II brake test. (a) A Class II brake test shall be.... In these circumstances, a Class II brake test shall be performed prior to the train's departure...

  11. 49 CFR 238.317 - Class II brake test.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Class II brake test. 238.317 Section 238.317... Requirements for Tier I Passenger Equipment § 238.317 Class II brake test. (a) A Class II brake test shall be.... In these circumstances, a Class II brake test shall be performed prior to the train's departure...

  12. Theoretical investigation of rotational rainbow structures in X-Na2 collisions using CI potential surfaces. II. Combined rotational-vibrational excitation for X = He scattering

    NASA Astrophysics Data System (ADS)

    Müller, Wolfgang; Schinke, Reinhard

    1981-08-01

    Combined rotational-vibrational excitaton cross sections for He-Na2 scattering are reported for collision energies of 0.05?E?0.15 eV. The infinite-order-sudden (IOS) approximation is used to decouple the rotational and the orbital angular momenta, whereas the vibrational degree of freedom is treated exactly by solving vibrationally coupled radial equations. An analytical potential energy surface obtained from 160 ab initio CI energies is used in these scattering calculations. The cross sections for vibrational excitation or de-excitation are extremely small compared to the vibrationally elastic cross sections but increase rapidly with the collision energy. The influence of the target vibration on pure rotational excitation processes is negligibly small for energies considered in this study, such that the rigid-rotor approximation applied previously for the same system is confirmed to be reasonable. Furthermore, the rotational rainbow structures which are characteristic for the He-Na2 system depend only very slightly on whether the molecule is initially in the ground n = 0 or the first vibrationally excited state n = 1. This was in contradiction to the experimental finding of Bergmann et al. [J. Chem. Phys. 72, 4777 (1980)], who reported a dramatic enhancement of the rotational energy transfer for scattering within the n = 1 vibrational state. The rotational rainbow maxima occur at almost equal positions independent of whether the transition is vibrationally elastic or inelastic. A small shift to wider scattering angles in the case of Δn = 1 is observed at lower energies.

  13. THE ARECIBO H II REGION DISCOVERY SURVEY

    SciTech Connect

    Bania, T. M.; Anderson, L. D.; Balser, Dana S.

    2012-11-10

    We report the detection of radio recombination line (RRL) emission using the Arecibo Observatory at X band (9 GHz, 3 cm) from 37 previously unknown H II regions in the Galactic zone 66 Degree-Sign {>=} l {>=} 31 Degree-Sign and | b | {<=} 1 Degree-Sign . This Arecibo H II Region Discovery Survey (Arecibo HRDS) is a continuation of the Green Bank Telescope (GBT) HRDS. The targets for the Arecibo HRDS have spatially coincident 24 {mu}m and 20 cm emission of a similar angular morphology and extent. To take advantage of Arecibo's sensitivity and small beam size, sources in this sample are fainter, smaller in angle, or in more crowded fields compared to those of the GBT HRDS. These Arecibo nebulae are some of the faintest H II regions ever detected in RRL emission. Our detection rate is 58%, which is low compared to the 95% detection rate for GBT HRDS targets. We derive kinematic distances to 23 of the Arecibo HRDS detections. Four nebulae have negative local standard of rest velocities and are thus unambiguously in the outer Galaxy. The remaining sources are at the tangent-point distance or farther. We identify a large, diffuse H II region complex that has an associated H I and {sup 13}CO shell. The {approx}90 pc diameter of the G52L nebula in this complex may be the largest Galactic H II region known, and yet it has escaped previous detection.

  14. Summary of CPAS Gen II Parachute Analysis

    NASA Technical Reports Server (NTRS)

    Morris, Aaron L.; Bledsoe, Kristin J.; Fraire, Usbaldo, Jr.; Moore, James W.; Olson, Leah M.; Ray, Eric

    2011-01-01

    The Orion spacecraft is currently under development by NASA and Lockheed Martin. Like Apollo, Orion will use a series of parachutes to slow its descent and splashdown safely. The Orion parachute system, known as the CEV Parachute Assembly System (CPAS), is being designed by NASA, the Engineering and Science Contract Group (ESCG), and Airborne Systems. The first generation (Gen I) of CPAS testing consisted of thirteen tests and was executed in the 2007-2008 timeframe. The Gen I tests provided an initial understanding of the CPAS parachutes. Knowledge gained from Gen I testing was used to plan the second generation of testing (Gen II). Gen II consisted of six tests: three singleparachute tests, designated as Main Development Tests, and three Cluster Development Tests. Gen II required a more thorough investigation into parachute performance than Gen I. Higher fidelity instrumentation, enhanced analysis methods and tools, and advanced test techniques were developed. The results of the Gen II test series are being incorporated into the CPAS design. Further testing and refinement of the design and model of parachute performance will occur during the upcoming third generation of testing (Gen III). This paper will provide an overview of the developments in CPAS analysis following the end of Gen I, including descriptions of new tools and techniques as well as overviews of the Gen II tests.

  15. Reddening and extinction towards H II regions

    NASA Technical Reports Server (NTRS)

    Caplan, James; Deharveng, Lise

    1989-01-01

    The light emitted by the gas in H II regions is attenuated by dust. This extinction can be measured by comparing H alpha, H beta, and radio continuum fluxes, since the intrinsic ratios of the Balmer line and thermal radio continuum emissivities are nearly constant for reasonable conditions in H II regions. In the case of giant extragalactic H II regions, the extinction was found to be considerably greater than expected. The dust between the Earth and the emitting gas may have an optical thickness which varies. The dust may be close enough to the source that scattered light contributes to the flux, or the dust may be actually mixed with the emitting gas. It is difficult to decide which configuration is correct. A rediscussion of this question in light of recent observations, with the Fabry-Perot spectrophotometers, of the large Galactic H II region is presented. The color excesses are compared for stars embedded in these H II regions with those derived (assuming the standard law) from the nebular extinction and reddening.

  16. PEP-II injection timing and controls

    SciTech Connect

    Bharadwaj, V.; Browne, M.; Crane, M.; Gromme, T.; Himel, T.; Ross, M.; Stanek, M.; Ronan, M.

    1997-07-01

    Hardware has been built and software written and incorporated in the existing SLC accelerator control system to control injection of beam pulses from the accelerator into the PEP-II storage rings currently under construction. Hardware includes a CAMAC module to delay the machine timing fiducial in order that a beam pulse extracted from a damping ring will be injected into a selected group of four 476 MHz buckets in a PEP-II ring. Further timing control is accomplished by shifting the phase of the bunches stored in the damping rings before extraction while leaving the phase of the PEP-II stored beam unchanged. The software which drives timing devices on a pulse-to-pulse basis relies on a dedicated communication link on which one scheduling microprocessor broadcasts a 128-bit message to all distributed control microprocessors at 360 Hz. PEP-II injection will be driven by the scheduling microprocessor according to lists specifying bucket numbers in arbitrary order, and according to scheduling constraints maximizing the useful beam delivered to the SLC collider currently in operation. These lists will be generated by a microprocessor monitoring the current stored per bucket in each of the PEP-II rings.

  17. Belle-II Experiment Network Requirements

    SciTech Connect

    Asner, David; Bell, Greg; Carlson, Tim; Cowley, David; Dart, Eli; Erwin, Brock; Godang, Romulus; Hara, Takanori; Johnson, Jerry; Johnson, Ron; Johnston, Bill; Dam, Kerstin Kleese-van; Kaneko, Toshiaki; Kubota, Yoshihiro; Kuhr, Thomas; McCoy, John; Miyake, Hideki; Monga, Inder; Nakamura, Motonori; Piilonen, Leo; Pordes, Ruth; Ray, Douglas; Russell, Richard; Schram, Malachi; Schroeder, Jim; Sevior, Martin; Singh, Surya; Suzuki, Soh; Sasaki, Takashi; Williams, Jim

    2013-05-28

    The Belle experiment, part of a broad-based search for new physics, is a collaboration of ~400 physicists from 55 institutions across four continents. The Belle detector is located at the KEKB accelerator in Tsukuba, Japan. The Belle detector was operated at the asymmetric electron-positron collider KEKB from 1999-2010. The detector accumulated more than 1 ab-1 of integrated luminosity, corresponding to more than 2 PB of data near 10 GeV center-of-mass energy. Recently, KEK has initiated a $400 million accelerator upgrade to be called SuperKEKB, designed to produce instantaneous and integrated luminosity two orders of magnitude greater than KEKB. The new international collaboration at SuperKEKB is called Belle II. The first data from Belle II/SuperKEKB is expected in 2015. In October 2012, senior members of the Belle-II collaboration gathered at PNNL to discuss the computing and neworking requirements of the Belle-II experiment with ESnet staff and other computing and networking experts. The day-and-a-half-long workshop characterized the instruments and facilities used in the experiment, the process of science for Belle-II, and the computing and networking equipment and configuration requirements to realize the full scientific potential of the collaboration's work.

  18. Mesospheric ozone measurements by SAGE II

    NASA Astrophysics Data System (ADS)

    Chu, D. A.; Cunnold, D. M.

    1994-04-01

    SAGE II observations of ozone at sunrise and sunset (solar zenith angle = 90 deg) at approximately the same tropical latitude and on the same day exhibit larger concentrations at sunrise than at sunset between 55 and 65 km. Because of the rapid conversion between atomic oxygen and ozone, the onion-peeling scheme used in SAGE II retrievals, which is based on an assumption of constant ozone, is invalid. A one-dimensional photochemical model is used to simulate the diurnal variation of ozone particularly within the solar zenith angle of 80 deg - 100 deg. This model indicates that the retrieved SAGE II sunrise and sunset ozone values are both overestimated. The Chapman reactions produce an adequate simulation of the ozone sunrise/sunset ratio only below 60 km, while above 60 km this ratio is highly affected by the odd oxygen loss due to odd hydrogen reactions, particularly OH. The SAGE II ozone measurements are in excellent agreement with model results to which an onion peeling procedure is applied. The SAGE II ozone observations provide information on the mesospheric chemistry not only through the ozone profile averages but also from the sunrise/sunset ratio.

  19. Mesospheric ozone measurements by SAGE II

    NASA Technical Reports Server (NTRS)

    Chu, D. A.; Cunnold, D. M.

    1994-01-01

    SAGE II observations of ozone at sunrise and sunset (solar zenith angle = 90 deg) at approximately the same tropical latitude and on the same day exhibit larger concentrations at sunrise than at sunset between 55 and 65 km. Because of the rapid conversion between atomic oxygen and ozone, the onion-peeling scheme used in SAGE II retrievals, which is based on an assumption of constant ozone, is invalid. A one-dimensional photochemical model is used to simulate the diurnal variation of ozone particularly within the solar zenith angle of 80 deg - 100 deg. This model indicates that the retrieved SAGE II sunrise and sunset ozone values are both overestimated. The Chapman reactions produce an adequate simulation of the ozone sunrise/sunset ratio only below 60 km, while above 60 km this ratio is highly affected by the odd oxygen loss due to odd hydrogen reactions, particularly OH. The SAGE II ozone measurements are in excellent agreement with model results to which an onion peeling procedure is applied. The SAGE II ozone observations provide information on the mesospheric chemistry not only through the ozone profile averages but also from the sunrise/sunset ratio.

  20. Centrifuge workers study. Phase II, completion report

    SciTech Connect

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom.

  1. PIP-II Status and Strategy

    SciTech Connect

    Holmes, Stephen; Derwent, Paul; Lebedev, Valeri; Mishra, Shekhar; Mitchell, Donald; Yakovlev, Vyacheslav P.

    2015-06-01

    Proton Improvement Plan-II (PIP-II) is the centerpiece of Fermilab's plan for upgrading the accelerator complex to establish the leading facility in the world for particle physics research based on intense proton beams. PIP-II has been developed to provide 1.2 MW of proton beam power at the start of operations of the Long Baseline Neutrino Facility (LBNF), while simultaneously providing a platform for eventual extension of LBNE beam power to >2MW and enabling future initiatives in rare processes research based on high duty factor/higher beam power operations. PIP-II is based on the construction of a new 800 MeV superconducting linac, augmented by improvements to the existing Booster, Recycler, and Main Injector complex. PIP-II is currently in the development stage with an R&D program underway targeting the front end and superconducting RF acceleration technologies. This paper will describe the status of the PIPII conceptual development, the associated technology R&D programs, and the strategy for project implementation.

  2. Stenogyria - not only in Chiari II malformation.

    PubMed

    Bekiesinska-Figatowska, Monika; Duczkowska, Agnieszka; Brągoszewska, Hanna; Duczkowski, Marek; Mierzewska, Hanna

    2014-12-15

    Stenogyria, meaning multiple small compacted gyri separated by shallow sulci, is reported in the literature in association with Chiari II malformation (CM II) which in turn is reported in association with myelomeningocele (MMC). The authors present five cases of stenogyria (and other abnormalities found in CM II, like callosal hypoplasia/dysplasia, agenesis of the anterior commissure, hypoplasia of the falx cerebri) in children without the history of MMC or any other form of open spinal dysraphism. In these cases stenogyria was associated with Chiari I malformation, rhombencephalosynapsis and spina bifida. Stenogyria, which is not a true neuronal migration disorder, should not be mistaken for polymicrogyria which is also present in CM II. It is histologically different from polymicrogyria because the cortex is normally organized. Also on MRI, the general sulcal pattern is preserved in stenogyria, while it is completely distorted in polymicrogyria. The authors conclude that features traditionally attributed to CM II, like stenogyria, occur not only in the population of patients with MMC as opposed to the widely accepted theory.

  3. 30 CFR Appendix II to Subpart D of... - Appendix II to Subpart D of Part 18

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACCESSORIES Machines Assembled With Certified or Explosion-Proof Components, Field Modifications of Approved Machines, and Permits To Use Experimental Equipment Pt. 18, Subpt. D, App. II Appendix II to Subpart D of Part 18 LIST OF FIGURES Figure No. Title 1 Typical layout drawing of a machine. 2 Sample bill...

  4. Introduction to Health Occupations Education II. Module No. I. Health Occupations Education II.

    ERIC Educational Resources Information Center

    Day, Nancy; And Others

    This package of seven modules that introduce health occupations II is one of six such packages containing a total of 46 modules that comprise Health Occupations Education II, the second course of a two-year course of study. Each module may contain some or all of the following components: introduction, directions, objectives, a list of learning…

  5. On Cu(II) Cu(II) distance measurements using pulsed electron electron double resonance

    NASA Astrophysics Data System (ADS)

    Yang, Zhongyu; Becker, James; Saxena, Sunil

    2007-10-01

    The effects of orientational selectivity on the 4-pulse electron electron double resonance (PELDOR) ESR spectra of coupled Cu(II)-Cu(II) spins are presented. The data were collected at four magnetic fields on a poly-proline peptide containing two Cu(II) centers. The Cu(II)-PELDOR spectra of this peptide do not change appreciably with magnetic field at X-band. The data were analyzed by adapting the theory of Maryasov, Tsvetkov, and Raap [A.G. Maryasov, Y.D. Tsvetkov, J. Raap, Weakly coupled radical pairs in solids:ELDOR in ESE structure studies, Appl. Magn. Reson. 14 (1998) 101-113]. Simulations indicate that orientational effects are important for Cu(II)-PELDOR. Based on simulations, the field-independence of the PELDOR data for this peptide is likely due to two effects. First, for this peptide, the Cu(II) g-tensor(s) are in a very specific orientation with respect to the interspin vector. Second, the flexibility of the peptide washes out the orientation effects. These effects reduce the suitability of the poly-proline based peptide as a good model system to experimentally probe orientational effects in such experiments. An average Cu(II)-Cu(II) distance of 2.1-2.2 nm was determined, which is consistent with earlier double quantum coherence ESR results.

  6. Employability Planning Process. STIP II (Skill Training Improvement Programs Round II).

    ERIC Educational Resources Information Center

    Los Angeles Community Coll. District, CA.

    Four reports are presented detailing procedures for improving the employability of students enrolled in the Los Angeles Community College District's Skill Training Improvement Programs (STIP II). Each report was submitted by one of the four STIP II programs: Los Angeles Southwest College's program for computer programming; the programs for…

  7. Type II achondrogenesis-hypochondrogenesis: identification of abnormal type II collagen.

    PubMed

    Godfrey, M; Hollister, D W

    1988-12-01

    We have extended the study of a mild case of type II achondrogenesis-hypochondrogenesis to include biochemical analyses of cartilage, bone, and the collagens produced by dermal fibroblasts. Type I collagen extracted from bone and types I and III collagen produced by dermal fibroblasts were normal, as was the hexosamine ratio of cartilage proteoglycans. Hyaline cartilage, however, contained approximately equal amounts of types I and II collagen and decreased amounts of type XI collagen. Unlike the normal SDS-PAGE mobility. Two-dimensional SDS-PAGE revealed extensive overmodification of all type II cyanogen bromide peptides in a pattern consistent with heterozygosity for an abnormal pro alpha 1(II) chain which impaired the assembly and/or folding of type II collagen. This interpretation implies that dominant mutations of the COL2A1 gene may cause type II achondrogenesis-hypochondrogenesis. More generally, emerging data implicating defects of type II collagen in the type II achondrogenesis-hypochondrogenesis-spondyloepiphyseal dysplasia congenita spectrum and in the Kniest-Stickler syndrome spectrum suggest that diverse mutations of this gene may be associated with widely differing phenotypic outcome. PMID:3195588

  8. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    ScienceCinema

    None

    2016-07-12

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  9. Validation of the Sexual Assault Symptom Scale II (SASS II) Using a Panel Research Design

    ERIC Educational Resources Information Center

    Ruch, Libby O.; Wang, Chang-Hwai

    2006-01-01

    To examine the utility of a self-report scale of sexual assault trauma, 223 female victims were interviewed with the 43-item Sexual Assault Symptom Scale II (SASS II) at 1, 3, 7, 11, and 15 months postassault. Factor analyses using principal-components extraction with an oblimin rotation yielded 7 common factors with 31 items. The internal…

  10. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    SciTech Connect

    2010-12-17

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  11. Characterization of Schizothorax prenanti cgnrhII gene: fasting affects cgnrhII expression.

    PubMed

    Wang, T; Yuan, D; Zhou, C; Lin, F; Chen, H; Wu, H; Wei, R; Xin, Z; Liu, J; Gao, Y; Chen, D; Yang, S; Pu, Y; Li, Z

    2014-08-01

    In this study, the role of chicken gonadotropin-releasing hormone II (cgnrhII) in feeding regulation was investigated in Schizothorax prenanti. First, the full-length S. prenanti cgnrhII cDNA consisted of 693 bp with an open reading frame of 261 bp encoding a protein of 86 amino acids. Next, cgnrhII was widely expressed in the central and peripheral tissues. Last, there were significant changes in cgnrhII mRNA expression in the fasted group compared to the fed group in the S. prenanti hypothalamus during 24 h fasting (P < 0.05). Furthermore, the cgnrhII gene expression presented a significant decrease in the fasted group compared with the fed group (P < 0.05) on days 3, 5 and 7, after re-feeding, there was no significant changes in cgnrhII mRNA expression level between refed and fed group on day 9 (P > 0.05). Thus, the results suggest that cGnRH II expression is influenced by fasting and the gene may be involved in feeding regulation in S. prenanti.

  12. Nickel(II) and copper(II) complexes with humic acid anions and their derivatives

    SciTech Connect

    Ryabova, I.N.

    2008-01-15

    Complexation of Ni(II) and Cu(II) in aqueous solutions with anions of humic acids, extracted from naturally oxidized coal, and with their hydroxymethyl derivatives is studied spectrophotometrically and potentiometrically. The complexation stoichiometry and the stability constants of the complexes are determined.

  13. 40 CFR Table 1 to Subpart II of... - General Provisions of Applicability to Subpart II

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false General Provisions of Applicability to Subpart II 1 Table 1 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National...

  14. Adsorption characteristics of Cu(II) and Pb(II) onto expanded perlite from aqueous solution.

    PubMed

    Sari, Ahmet; Tuzen, Mustafa; Citak, Demirhan; Soylak, Mustafa

    2007-09-01

    The adsorption characteristics of Cu(II) and Pb(II) onto expanded perlite (EP) from aqueous solution were investigated with respect to the changes in pH of solution, adsorbent dosage, contact time and temperature of solution. For the adsorption of both metal ions, the Langmuir isotherm model fitted to equilibrium data better than the Freundlich isotherm model. Using the Langmuir model equation, the monolayer adsorption capacity of EP was found to be 8.62 and 13.39 mg/g for Cu(II) and Pb(II) ions, respectively. Dubinin-Radushkevich (D-R) isotherm model was also applied to the equilibrium data and the mean free energies of adsorption were found as 10.82 kJ/mol for Cu(II) and 9.12 kJ/mol for Pb(II) indicating that the adsorption of both metal ions onto EP was taken place by chemical ion-exchange. Thermodynamic functions, the change of free energy (DeltaG degrees ), enthalpy (DeltaH degrees ) and entropy (DeltaS degrees ) of adsorption were also calculated for each metal ions. These parameters showed that the adsorption of Cu(II) and Pb(II) ions onto EP was feasible, spontaneous and exothermic at 20-50 degrees C. Experimental data were also evaluated in terms of kinetic characteristics of adsorption and it was found that adsorption process for both metal ions followed well pseudo-second-order kinetics.

  15. Decommissioning of Experimental Breeder Reactor - II Complex, Post Sodium Draining

    SciTech Connect

    J. A. Michelbacher; S. Paul Henslee; Collin J. Knight; Steven R. sherman

    2005-09-01

    The Experimental Breeder Reactor - II (EBR-II) was shutdown in September 1994 as mandated by the United States Department of Energy. This sodium-cooled reactor had been in service since 1964. The bulk sodium was drained from the primary and secondary systems and processed. Residual sodium remaining in the systems after draining was converted into sodium bicarbonate using humid carbon dioxide. This technique was tested at Argonne National Laboratory in Illinois under controlled conditions, then demonstrated on a larger scale by treating residual sodium within the EBR-II secondary cooling system, followed by the primary tank. This process, terminated in 2002, was used to place a layer of sodium bicarbonate over all exposed surfaces of sodium. Treatment of the remaining EBR-II sodium is governed by the Resource Conservation and Recovery Act (RCRA). The Idaho Department of Environmental Quality issued a RCRA Operating Permit in 2002, mandating that all hazardous materials be removed from EBR-II within a 10 year period, with the ability to extend the permit and treatment period for another 10 years. A preliminary plan has been formulated to remove the remaining sodium and NaK from the primary and secondary systems using moist carbon dioxide, steam and nitrogen, and a water flush. The moist carbon dioxide treatment was resumed in May 2004. As of August 2005, approximately 60% of the residual sodium within the EBR-II primary tank had been treated. This process will continue through the end of 2005, when it is forecast that the process will become increasingly ineffective. At that time, subsequent treatment processes will be planned and initiated. It should be noted that the processes and anticipated costs associated with these processes are preliminary. Detailed engineering has not been performed, and approval for these methods has not been obtained from the regulator or the sponsors.

  16. Type II supernovae as probes of environment metallicity: observations of host H II regions

    NASA Astrophysics Data System (ADS)

    Anderson, J. P.; Gutiérrez, C. P.; Dessart, L.; Hamuy, M.; Galbany, L.; Morrell, N. I.; Stritzinger, M. D.; Phillips, M. M.; Folatelli, G.; Boffin, H. M. J.; de Jaeger, T.; Kuncarayakti, H.; Prieto, J. L.

    2016-05-01

    Context. Spectral modelling of type II supernova atmospheres indicates a clear dependence of metal line strengths on progenitor metallicity. This dependence motivates further work to evaluate the accuracy with which these supernovae can be used as environment metallicity indicators. Aims: To assess this accuracy we present a sample of type II supernova host H ii-region spectroscopy, from which environment oxygen abundances have been derived. These environment abundances are compared to the observed strength of metal lines in supernova spectra. Methods: Combining our sample with measurements from the literature, we present oxygen abundances of 119 host H ii regions by extracting emission line fluxes and using abundance diagnostics. These abundances are then compared to equivalent widths of Fe ii 5018 Å at various time and colour epochs. Results: Our distribution of inferred type II supernova host H ii-region abundances has a range of ~0.6 dex. We confirm the dearth of type II supernovae exploding at metallicities lower than those found (on average) in the Large Magellanic Cloud. The equivalent width of Fe ii 5018 Å at 50 days post-explosion shows a statistically significant correlation with host H ii-region oxygen abundance. The strength of this correlation increases if one excludes abundance measurements derived far from supernova explosion sites. The correlation significance also increases if we only analyse a "gold" IIP sample, and if a colour epoch is used in place of time. In addition, no evidence is found of a correlation between progenitor metallicity and supernova light-curve or spectral properties - except for that stated above with respect to Fe ii 5018 Å equivalent widths - suggesting progenitor metallicity is not a driving factor in producing the diversity that is observed in our sample. Conclusions: This study provides observational evidence of the usefulness of type II supernovae as metallicity indicators. We finish with a discussion of the

  17. Effect of biofilm coatings at metal-oxide/water interfaces II: Competitive sorption between Pb(II) and Zn(II) at Shewanella oneidensis/metal-oxide/water interfaces

    NASA Astrophysics Data System (ADS)

    Wang, Yingge; Gélabert, Alexandre; Michel, F. Marc; Choi, Yongseong; Eng, Peter J.; Spormann, Alfred M.; Brown, Gordon E.

    2016-09-01

    Competitive sorption of Pb(II) and Zn(II) on Shewanella oneidensis MR-1 biofilm-coated single-crystal α-Al2O3 (1 -1 0 2) and α-Fe2O3 (0 0 0 1) surfaces was investigated using long-period X-ray standing wave-florescence yield (LP-XSW-FY) spectroscopy. In situ partitioning of aqueous Pb(II) and Zn(II) between the biofilms and underlying metal-oxide substrates was probed following exposure of these complex interfaces to equi-molar Pb and Zn solutions (0.01 M NaNO3 as background electrolyte, pH = 6.0, and 3-h equilibration time). At higher Pb and Zn concentrations (⩾10-5 M), more than 99% of these ions partitioned into the biofilms at S. oneidensis/α-Al2O3 (1 -1 0 2)/water interfaces, which is consistent with the partitioning behavior of both Pb(II) or Zn(II) in single-metal-ion experiments. Thus, no apparent competitive effects were found in this system at these relatively high metal-ion concentrations. However, at lower equi-molar concentrations (⩽10-6 M), Pb(II) and Zn(II) partitioning in the same system changed significantly compared to the single-metal-ion systems. The presence of Zn(II) decreased Pb(II) partitioning onto α-Al2O3 (1 -1 0 2) substantially (∼52% to ∼13% at 10-7 M, and ∼23% to ∼5% at 10-6 M), whereas the presence of Pb(II) caused more Zn(II) to partition onto α-Al2O3 (1 -1 0 2) surfaces (∼15% to ∼28% at 10-7 M, and ∼1% to ∼7% at 10-6 M). The higher observed partitioning of Zn(II) (∼28%) at the α-Al2O3 (1 -1 0 2) surfaces compared to Pb(II) (∼13%) in the mixed-metal-ion systems at the lowest concentration (10-7 M) suggests that Zn(II) is slightly favored over Pb(II) for sorption sites on α-Al2O3 (1 -1 0 2) surfaces under our experimental conditions. Competitive sorption of Pb(II) and Zn(II) at S. oneidensis/α-Fe2O3 (0 0 0 1)/water interfaces at equi-molar metal-ion concentrations of ⩽10-6 M showed that the presence of Pb(II) ions decreased Zn(II) partitioning onto α-Fe2O3 (0 0 0 1) significantly (∼45% to <1% at 10

  18. Ax(H3O)2-xMn5(HPO3)6 (A = Li, Na, K and NH4): open-framework manganese(ii) phosphites templated by mixed cationic species.

    PubMed

    Orive, Joseba; Fernández de Luis, Roberto; Fernández, Jesús Rodríguez; Lezama, Luis; Arriortua, María I

    2016-07-26

    Ax(H3O)2-xMn5(HPO3)6 (A = Li, x = 0.55 (1-Li); A = Na, x = 0.72 (2-Na); A = K, x = 0.30 (3-K); A = NH4, x = 0.59 (4-NH4)) phases were synthesized by employing mild hydrothermal conditions. 1-Li was studied by single crystal X-ray diffraction, while sodium, potassium and ammonium containing analogues were obtained as polycrystalline samples and characterized by powder X-ray diffraction. The four compounds were characterized by ICP-Q-MS, thermal analysis and XPS, IR, UV/Vis and EPR spectroscopy. Single crystal data indicate that 1-Li crystallizes in the P3[combining macron]c1 space group with lattice parameters a = 10.3764(1) Å and c = 9.4017(1) Å with Z = 2. The crystal structure of these phases is constituted by a three-dimensional [Mn(ii)5(HPO3)6](2-) anionic skeleton templated by alkali metal and ammonium cations together with protonated water molecules. Such an inorganic framework is formed by layers of edge-sharing MnO6 octahedra placed in the ab plane and joined along the c direction through phosphite pseudotetrahedra. The sheets display 12-membered ring channels parallel to the c-axis, ca. 5 Å in diameter, where the extraframework species display a strong disorder. EPR measurements point to the existence of short range ferromagnetic interactions around 12 K. Magnetic susceptibility and heat capacity measurements show that all the compounds exhibit long range antiferromagnetic order below circa 4 K, with a significant magnetocaloric effect around the Neel temperature.

  19. Ax(H3O)2-xMn5(HPO3)6 (A = Li, Na, K and NH4): open-framework manganese(ii) phosphites templated by mixed cationic species.

    PubMed

    Orive, Joseba; Fernández de Luis, Roberto; Fernández, Jesús Rodríguez; Lezama, Luis; Arriortua, María I

    2016-07-26

    Ax(H3O)2-xMn5(HPO3)6 (A = Li, x = 0.55 (1-Li); A = Na, x = 0.72 (2-Na); A = K, x = 0.30 (3-K); A = NH4, x = 0.59 (4-NH4)) phases were synthesized by employing mild hydrothermal conditions. 1-Li was studied by single crystal X-ray diffraction, while sodium, potassium and ammonium containing analogues were obtained as polycrystalline samples and characterized by powder X-ray diffraction. The four compounds were characterized by ICP-Q-MS, thermal analysis and XPS, IR, UV/Vis and EPR spectroscopy. Single crystal data indicate that 1-Li crystallizes in the P3[combining macron]c1 space group with lattice parameters a = 10.3764(1) Å and c = 9.4017(1) Å with Z = 2. The crystal structure of these phases is constituted by a three-dimensional [Mn(ii)5(HPO3)6](2-) anionic skeleton templated by alkali metal and ammonium cations together with protonated water molecules. Such an inorganic framework is formed by layers of edge-sharing MnO6 octahedra placed in the ab plane and joined along the c direction through phosphite pseudotetrahedra. The sheets display 12-membered ring channels parallel to the c-axis, ca. 5 Å in diameter, where the extraframework species display a strong disorder. EPR measurements point to the existence of short range ferromagnetic interactions around 12 K. Magnetic susceptibility and heat capacity measurements show that all the compounds exhibit long range antiferromagnetic order below circa 4 K, with a significant magnetocaloric effect around the Neel temperature. PMID:27412966

  20. Cobalt(II) Oxidation by the Marine Manganese(II)-Oxidizing Bacillus sp. Strain SG-1

    PubMed Central

    Lee, Yoon; Tebo, Bradley M.

    1994-01-01

    The geochemical cycling of cobalt (Co) has often been considered to be controlled by the scavenging and oxidation of Co(II) on the surface of manganese [Mn(III,IV)] oxides or manganates. Because Mn(II) oxidation in the environment is often catalyzed by bacteria, we have investigated the ability of Mn(II)-oxidizing bacteria to bind and oxidize Co(II) in the absence of Mn(II) to determine whether some Mn(II)-oxidizing bacteria also oxidize Co(II) independently of Mn oxidation. We used the marine Bacillus sp. strain SG-1, which produces mature spores that oxidize Mn(II), apparently due to a protein in their spore coats (R.A. Rosson and K. H. Nealson, J. Bacteriol. 151:1027-1034, 1982; J. P. M. de Vrind et al., Appl. Environ. Microbiol. 52:1096-1100, 1986). A method to measure Co(II) oxidation using radioactive 57Co as a tracer and treatments with nonradioactive (cold) Co(II) and ascorbate to discriminate bound Co from oxidized Co was developed. SG-1 spores were found to oxidize Co(II) over a wide range of pH, temperature, and Co(II) concentration. Leucoberbelin blue, a reagent that reacts with Mn(III,IV) oxides forming a blue color, was found to also react with Co(III) oxides and was used to verify the presence of oxidized Co in the absence of added Mn(II). Co(II) oxidation occurred optimally around pH 8 and between 55 and 65°C. SG-1 spores oxidized Co(II) at all Co(II) concentrations tested from the trace levels found in seawater to 100 mM. Co(II) oxidation was found to follow Michaelis-Menten kinetics. An Eadie-Hofstee plot of the data suggests that SG-1 spores have two oxidation systems, a high-affinity-low-rate system (Km, 3.3 × 10-8 M; Vmax, 1.7 × 10-15 M · spore-1 · h-1) and a low-affinity-high-rate system (Km, 5.2 × 10-6 M; Vmax, 8.9 × 10-15 M · spore-1 · h-1). SG-1 spores did not oxidize Co(II) in the absence of oxygen, also indicating that oxidation was not due to abiological Co(II) oxidation on the surface of preformed Mn(III,IV) oxides. These

  1. Validation of the Sexual Assault Symptom Scale II (SASS II) using a panel research design.

    PubMed

    Ruch, Libby O; Wang, Chang-Hwai

    2006-11-01

    To examine the utility of a self-report scale of sexual assault trauma, 223 female victims were interviewed with the 43-item Sexual Assault Symptom Scale II (SASS II) at 1, 3, 7, 11, and 15 months postassault. Factor analyses using principal-components extraction with an oblimin rotation yielded 7 common factors with 31 items. The internal consistency was high for 4 factors and moderate for 2 factors. The multitrait-multimethod matrix, correlating the factor subscale scores of self-reported trauma and clinical assessment ratings, demonstrated both convergent and discriminant validity, indicating that the SASS II has construct validity. Correlations between the SASS II subscales and the intrusion subscale of the Impact of Events Scale also indicated the convergent and discriminant validity of the SASS II. Significant positive correlations between current and prior trauma levels further evidence the validity of the SASS.

  2. XAFS studies of Pb(II)-chloro and Hg(II)-chloro ternary complexes on goethite

    USGS Publications Warehouse

    Bargar, J.R.; Persson, Petra; Brown, Gordon E.

    1997-01-01

    EXAFS spectroscopy was used to study Pb(II) and Hg(II) adsorption complexes on goethite (??-FeOOH) in the presence of Cl-. At pH 7, the dominant Pb(II) species are bonded to edges of FeO6 octahedra and are similar to complexes that occur in the absence of Cl-. At pH ??? 6, Pb(II)-chloro ternary complexes predominate and are bonded to corners of FeO6 octahedra. At pH 6.5, linear Hg(OH)Cl ternary complexes predominate that are bonded to goethite through surface oxygens in a bent Hg-O-Fe geometry. In the absence of Cl-, the Hg(II) surface complexes retain this basic geometry, but an OH group replaces the chloride ion in the first coordination shell.

  3. Supported liquid membrane based removal of lead(II) and cadmium(II) from mixed feed: Conversion to solid waste by precipitation.

    PubMed

    Bhatluri, Kamal Kumar; Manna, Mriganka Sekhar; Ghoshal, Aloke Kumar; Saha, Prabirkumar

    2015-12-15

    Simultaneous removal of two heavy metals, lead(II) and cadmium(II), from mixed feed using supported liquid membrane (SLM) based technique is investigated in this work. The carrier-solvent combination of "sodium salt of Di-2-ethylhexylphosphoric acid (D2EHPA) (4% w/w) in environmentally benign coconut oil" was immobilized into the pores of solid polymeric polyvinylidene fluoride (PVDF) support. Sodium carbonate (Na2CO3) was used as the stripping agent. Carbonate salts of lead(II) and cadmium(II) were formed in the stripping side interface and they were insoluble in water leading to precipitation inside the stripping solution. The transportation of solute is positively affected due to the precipitation. Lead(II) removal was found to be preferential due to its favorable electronic configuration. The conversion of the liquid waste to the solid one was added advantage for the final removal of hazardous heavy metals. PMID:26252994

  4. Spectroscopic and thermal degradation behavior of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes with thiopental sodium anesthesia drug

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.

    2013-04-01

    A new series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized with thiopental sodium anesthesia drug. The elemental analyses of the complexes are confined to stoichiometry of the formulas [M(TPL)3]ṡnH2O (M = Cr(III) or Fe(III); n = 6 or 5), [M(TPL)2(H2O)2]ṡnH2O (M = Mn(II), Co(II) or Ni(II); n = 0 or 4), and [M(TPL)2] (M = Cu(II) or Zn(II); n = 2 or 0) respectively, where TPL is thiopental chelating agent. Structures have been discussed and suggested upon elemental analyses, infrared, Raman, electronic, electron spin resonance, 1H NMR spectral data and magnetic studies. The X-ray powder diffraction (XRD) was performed of metal complexes. The XRD patterns indicate crystalline nature for the complexes. The measured low molar conductance values in dimethylsulfoxide indicate that the complexes are non-electrolyte nature. Spectroscopic discussion refer that coordination take place through three types: Cdbnd N (pyrimidine moiety) nitrogen and C2sbnd S (2-thiolate group) for Cr(III), Mn(II) and Fe(III), C6dbnd O (amido group) oxygen and C2sbnd S (2-thiolate group) for Co(II) and Ni(II), and Cu(II) and Zn(II) ions coordinated via Cdbnd N (pyrimidine moiety) nitrogen, C2dbnd S (2-thiolate group) and C6dbnd O (amido group) oxygen, respectively. The thermal behavior (TG/DTG/DTA) of the complexes was studied and kinetic parameters were determined by Horowitz-Metzger and Coats-Redfern methods. The thiopental and its complexes have been screened for their antimicrobial (G+ and G-) bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa) and fungi (Aspergillus flavus and Candida albicans) activities by minimum inhibitory concentration (MIC) method.

  5. Assessing the Impact of Tiotropium on Lung Function and Physical Activity in GOLD Stage II COPD Patients who are Naïve to Maintenance Respiratory Therapy: A Study Protocol.

    PubMed

    Troosters, Thierry; Weisman, Idelle; Dobbels, Fabienne; Giardino, Nicholas; Valluri, Srinivas Rao

    2011-01-01

    Physical activity status is increasingly recognized as a reliable predictor of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). The reduction in physical activity occurs earlier in the clinical course of COPD than previously appreciated, possibly arising from breathlessness, reduced exercise tolerance, and adoption of a more sedentary lifestyle. To date, no clinical trial has evaluated the impact of pharmacotherapy on both lung function and physical activity. We recently designed a study that evaluates the impact of tiotropium (a once-daily inhaled anticholinergic) on lung function and physical activity in a maintenance/treatment-naïve Global Initiative for Chronic Obstructive Lung Disease (GOLD) Stage II COPD cohort. Previous studies have demonstrated that tiotropium improves lung function and exercise tolerance; whether these benefits translate into improvements in physical activity is the focus of the current work. Here we describe the rationale and challenges in developing and implementing this study and review its unique features and novel design, including: utility of direct activity monitoring in multicenter clinical trials; importance of behavioral-modification techniques (including motivational interviewing to improve patient self-efficacy and adherence for a healthy, more active lifestyle); utility of individualized activity plans that provide an integrated approach with pharmacotherapy and behavioral modification to help patients achieve a more active lifestyle. PMID:21503263

  6. Competitive adsorption of Cu(II)-EDTA and Cd(II)-EDTA onto TiO{sub 2}

    SciTech Connect

    Yang, J.K.; Davis, A.P.

    1999-08-01

    Cu(II), EDTA, Cu(II)-EDTA, Cd(II)-EDTA, and Cu(II)/Cd(II) and Cu(II)-EDTA/Cd(II)-EDTA competitive adsorption onto TiO{sub 2} has been studied with variation of pH and concentration. For Cu(II) and EDTA, typical cationic and anionic types of adsorption are noted, respectively. Ligand-type adsorption is found for Cu(II)-EDTA and Cd(II)-EDTA under both single and competitive conditions. Surface complexation modeling considered inner-sphere complexation and the diffuse layer model employing MINTEQA2; surface complexes used include Ti-(OH{sub 2})O-Cu{sup +}, Ti-(OH)EDTAH{sub 2}{sup {minus}2}, Ti-(OH)EDTA-Cu{sup {minus}2}, and Ti-(OH)EDTA-Cd{sup {minus}2}. Experimental and model predictions suggest no competitive adsorption between Cu(II) and Cd(II) at 5 {times} 10{sup {minus}5} M. On the other hand, adsorption data and model predictions indicate that Cd(II)-EDTA adsorption is favored over that of Cu(II)-EDTA with some competition for adsorption sites. Cd(II)-EDTA Adsorption was only slightly affected by the presence of Cu(II)-EDTA; however, Cu(II)-EDTA adsorption was strongly influenced by the presence of Cd(II)-EDTA, especially as the molar ratio of Cd(II)-EDTA/Cu(II)-EDTA increased. A modified surface complexation constant for Cd(II)-EDTA is required to explain the competitive data, suggesting surface site heterogeneity.

  7. Zinc(II), iron(II/III) and ruthenium(II) complexes of o-phenylenediamine derivatives: oxidative dehydrogenation and photoluminescence.

    PubMed

    Chaudhuri, Satyabrata; Patra, Sarat Chandra; Saha, Pinaki; Saha Roy, Amit; Maity, Suvendu; Bera, Sachinath; Saha Sardar, Pinki; Ghosh, Sanjib; Weyhermüller, Thomas; Ghosh, Prasanta

    2013-11-14

    Reactions of benzoyl pyridine, o-phenylenediamine and anhydrous ZnX2 in methanol afford imine complexes [Zn(L1)X2] (X = Cl, 1; X = Br, 2) in good yields (L1 = (E)-N(1)-(phenyl(pyridin-2-yl)methylene)benzene-1,2-diamine). The reduction of 1 with NaBH4 affords (E)-N(1)-(phenyl(pyridine-2-yl)methylene)benzene-1,2-diamine (L2H). The reaction of L2H with [Ru(II)(PPh3)3Cl2] results in the oxidative dehydrogenation to L1 generating cis-[Ru(II)(L1)(PPh3)Cl2] (3). The reaction of L2H with salicylaldehyde affords (E)-2-(((2-((phenyl(pyridin-2-yl)methyl)amino)phenyl)imino)methyl)phenol (L3H2). The reaction of L3H2 with anhydrous FeCl3 in CH3OH affords cis-[Fe(III)(L3H(-))Cl2] (4). Reaction of L3H2 with [Ru(II)(PPh3)3Cl2] results in the oxidative dehydrogenation to diimine, L4H, affording trans-[Ru(II)(L4(-))(PPh3)2](+), which is isolated as trans-[Ru(II)(L4(-))(PPh3)2]PF6 (5(+)PF6(-)) (L4H = 2-((E)-(2-((E)-phenyl(pyridin-2-yl)methyleneamino)phenylimino)methyl)phenol). The reduction of L3H2 with NaBH4 produces 2-(((2-((phenyl(pyridin-2-yl)methyl)amino)phenyl)amino)methyl)phenol (L5H3). With iron(III) L5H3 undergoes oxidative dehydrogenation to L3H2 affording 4, while with [Ru(II)(PPh3)3Cl2], L5H3 undergoes 4e + 4H(+) transfer giving 5(+). A fluid solution of L3H2 at 298 K exhibits an emission band at 470 nm (λ(ex) = 330 nm, τ1 = 3.70 ns) and a weaker band at 525 nm (λ(ex) = 330, 390 nm, τ1 = 1.1 ns) at higher concentrations due to molecular aggregation, which are temperature dependent. 4 is brightly emissive (λ(ex) = 330 nm, λ(em) = 450 nm, Φ = 0.586, τ1 = 3.70 ns). Time resolved emission spectra (TRES) and lifetime measurements confirm that the lower energy absorption band of L3H2 at 390 nm, which is absent in complex 4, has a larger non-radiative rate constant (k(nr)). The redox innocent Al(III) adduct of L3H2 is fluorescent (λ(ex) = 330 nm, λ(em) = 450 nm, τ1 = 3.70 ns). On the contrary, the cis-[Fe(II)(L3H(-))Cl2](-) and cis-[Co(L3H(-))Cl2](-) analogues are non

  8. TRUPACT-II residue pipe payload container

    SciTech Connect

    Geinitz, R.; Gregory, P.

    1995-06-01

    This paper summarizes the project to develop, test and certify a new payload container for the TRUPACT-II, a Type B packaging for the shipment of transuranic waste. The new payload container will provide segregation of plutonium waste materials within the TRUPACT-II. This segregation of fissile contents will support a new criticality safety analysis that may allow an increase in the TRUPACT-II Pu-239 Fissile Gram Equivalent (FGE) limit from 325 grams to 2800 grams. The need for this project was brought about by the end of the Cold War and the resulting shift in value of plutonium residues from providing recoverable Defense Program material to being considered disposable waste. This paper will not cover many of the details of the project but will instead aim to provide a general picture of all the project activities.

  9. SHIELD II: WSRT HI Spectral Line Observations

    NASA Astrophysics Data System (ADS)

    Gordon, Alex Jonah Robert; Cannon, John M.; Adams, Elizabeth A.; SHIELD II Team

    2016-01-01

    The "Survey of HI in Extremely Low-mass Dwarfs II" ("SHIELD II") is a multiwavelength, legacy-class observational campaign that is facilitating the study of both internal and global evolutionary processes in low-mass dwarf galaxies discovered by the Arecibo Legacy Fast ALFA (ALFALFA) survey. We present new results from WSRT HI spectral line observations of 22 galaxies in the SHIELD II sample. We explore the morphology and kinematics by comparing images of the HI surface densities and the intensity weighted velocity fields with optical images from HST, SDSS, and WIYN. In most cases the HI and stellar populations are cospatial; projected rotation velocities range from less than 10 km/s to roughly 30 km/s.Support for this work was provided by NSF grant AST-1211683 to JMC at Macalester College, and by NASA through grant GO-13750 from the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS5-26555.

  10. Photoinactivation of photosystem II by flashing light.

    PubMed

    Szilárd, András; Sass, László; Hideg, Eva; Vass, Imre

    2005-06-01

    Inhibition of Photosystem II (PS II) activity by single turnover visible light flashes was studied in thylakoid membranes isolated form spinach. Flash illumination results in decreased oxygen evolving activity of PS II, which effect is most pronounced when the water-oxidizing complex is in the S2 and S3 states, and increases with increasing time delay between the subsequent flashes. By applying the fluorescent spin-trap DanePy, we detected the production of singlet oxygen, whose amount was increasing with increasing flash spacing. These findings were explained in the framework of a model, which assumes that recombination of the S2QB - and S3QB - states generate the triplet state of the reaction center chlorophyll and lead to the production of singlet oxygen.

  11. SHIELD II: VLA HI Spectral Line Observations

    NASA Astrophysics Data System (ADS)

    Lee, Eojin; Cannon, John M.; McNichols, Andrew; Teich, Yaron; SHIELD II Team

    2016-01-01

    The "Survey of HI in Extremely Low-mass Dwarfs II" ("SHIELD II") is a multiwavelength, legacy-class observational campaign that is facilitating the study of both internal and global evolutionary processes in low-mass dwarf galaxies discovered by the Arecibo Legacy Fast ALFA (ALFALFA) survey. We present new results from low-resolution D-configuration VLA HI spectral line observations of 6 galaxies in the SHIELD II sample. We explore the morphology and kinematics by comparing images of the HI surface densities and the intensity weighted velocity fields with optical images from SDSS and WIYN. These data allow us to localize the HI gas and to study the bulk neutral gas kinematics.Support for this work was provided by NSF grant AST-1211683 to JMC at Macalester College.

  12. ORION II bus demonstration. Demonstration report (Final)

    SciTech Connect

    Shanley, J.

    1989-02-01

    The Central New York Regional Transportation Authority conducted an 18-month demonstration to determine how the ORION II bus operates in actual service. The ORION II vehicle is a small low floor, accessible heavy duty, diesel-powered transit bus designed to meet the needs of the elderly and handicapped. It has the capacity to seat 26 passengers with 4 wheelchair lockdowns. Side and rear doors are equipped with electrically powered ramps. Eight Thomas vehicles (22-foot, 11,500 lbs, wheelchair equipped, gasoline fueled) were also tested during the demonstration period. Operations (fuel and oil usage) and maintenance (scheduled and unscheduled) data were collected and charted-out in the report as well as driver, passenger, and maintenance surveys. This report provides descriptions, photographs, and comparison charts of both the diesel-fueled ORION II transit bus and the gasoline-fueled Thomas vehicles along with the demonstration test plan, evaluations, conclusions, and survey results.

  13. Mutagenic effects of lead (II) bromide.

    PubMed

    Maslat, A O; Haas, H J

    1989-12-01

    The mutagenicity of lead (II) bromide (a combustion product of the gasoline additives lead (IV) tetraethyl and 1,2-dibromoethane) was investigated using various strains of bacteria. Taking prodigiosin (the red pigment) production as a marker, lead (II) bromide was found to be mutagenic in S. marcescens, leading to the appearance of white mutant colonies that are unable to produce such a pigment. This compound was also found to be mutagenic in E. coli KMBL1851, resulting in the appearance of rifampicin-resistant mutants in addition to Met+ and His+ revertants. Some of the S. marcescens mutants were found to be reversible, able to resynthesize prodigiosin. Differences in the sensitivity to antibiotics as well as in the biochemical properties were detected between the mutants and their corresponding wild types. Lead (II) bromide gave positive results in the Ames test performed with strain TA 1535.

  14. Validation of SAGE II NO2 measurements

    NASA Technical Reports Server (NTRS)

    Cunnold, D. M.; Zawodny, J. M.; Chu, W. P.; Mccormick, M. P.; Pommereau, J. P.; Goutail, F.

    1991-01-01

    The validity of NO2 measurements from the stratospheric aerosol and gas experiment (SAGE) II is examined by comparing the data with climatological distributions of NO2 and by examining the consistency of the observations themselves. The precision at high altitudes is found to be 5 percent, which is also the case at specific low altitudes for certain latitudes where the mixing ratio is 4 ppbv, and the precision is 0.2 ppbv at low altitudes. The autocorrelation distance of the smoothed profile measurement noise is 3-5 km and 10 km for 1-km and 5-km smoothing, respectively. The SAGE II measurements agree with spectroscopic measurements to within 10 percent, and the SAGE measurements are about 20 percent smaller than average limb monitor measurements at the mixing ratio peak. SAGE I and SAGE II measurements are slightly different, but the difference is not attributed to changes in atmospheric NO2.

  15. Type II endoleaks: challenges and solutions

    PubMed Central

    Brown, Andrew; Saggu, Greta K; Bown, Matthew J; Sayers, Robert D; Sidloff, David A

    2016-01-01

    Type II endoleaks are the most common endovascular complications of endovascular abdominal aortic aneurysm repair (EVAR); however, there has been a divided opinion regarding their significance in EVAR. Some advocate a conservative approach unless there is clear evidence of sac expansion, while others maintain early intervention is best to prevent adverse late outcomes such as rupture. There is a lack of level-one evidence in this challenging group of patients, and due to a low event rate of complications, large numbers of patients would be required in well-designed trials to fully understand the natural history of type II endoleak. This review will discuss the imaging, management, and outcome of patients with isolated type II endoleaks following infra-renal EVAR. PMID:27042087

  16. Type II seesaw dominance in SO(10)

    SciTech Connect

    Melfo, Alejandra; Ramirez, Alba; Senjanovic, Goran

    2010-10-01

    Grand unified theories where the neutrino mass is given by type II seesaw have the potential to provide interesting connections between the neutrino and charged fermion sectors. We explore the possibility of having a dominant type II seesaw contribution in supersymmetric SO(10). We show that this can be achieved in the model where symmetry breaking is triggered by 54 and 45 dimensional representations, without the need for additional fields other than those already required to have a realistic charged fermion mass spectrum. Physical consequences, such as the implementation of the Bajc, Senjanovic, and Vissani mechanism, the possibility of the fields responsible for type II seesaw dominance being messengers of supersymmetry breaking, and the realization of baryo and leptogenesis in these theories, are discussed.

  17. Intrafibrillar Mineral May be Absent in Dentinogenesis Imperfecta Type II (DI-II)

    SciTech Connect

    Pople, John A.

    2001-03-29

    High-resolution synchrotron radiation computed tomography (SRCT) and small angle x-ray scattering (SAXS) were performed on normal and dentinogenesis imperfecta type II (DI-II) teeth. Three normal and three DI-II human third molars were used in this study. The normal molars were unerupted and had intact enamel; donors were female and ranged in age from 18-21y. The DI-II specimens, which were also unerupted with intact enamel, came from a single female donor age 20y. SRCT showed that the mineral concentration was 33% lower on average in the DI-II dentin with respect to normal dentin. The SAXS spectra from normal dentin exhibited low-angle diffraction peaks at harmonics of 67.6 nm, consistent with nucleation and growth of the apatite phase within gaps in the collagen fibrils (intrafibrillar mineralization). In contrast, the low-angle peaks were almost nonexistent in the DI-II dentin. Crystallite thickness was independent of location in both DI-II and normal dentin, although the crystallites were significantly thicker in DI-II dentin (6.8 nm (s.d. = 0.5) vs 5.1 nm (s.d. = 0.6)). The shape factor of the crystallites, as determined by SAXS, showed a continuous progression in normal dentin from roughly one-dimensional (needle-like) near the pulp to two-dimensional (plate-like) near the dentin-enamel junction. The crystallites in DI-II dentin, on the other hand, remained needle-like throughout. The above observations are consistent with an absence of intrafibrillar mineral in DI-II dentin.

  18. Testicular gonadotropin-releasing hormone II receptor (GnRHR-II) knockdown constitutively impairs diurnal testosterone secretion in the boar

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The second mammalian GnRH isoform (GnRH-II) and its specific receptor (GnRHR-II) are highly expressed in the testis, suggesting an important role in testis biology. Gene coding errors prevent the production of GnRH-II and GnRHR-II in many species, but both genes are functional in swine. We have demo...

  19. Five coordinate M(II)-diphenolate [M = Zn(II), Ni(II), and Cu(II)] Schiff base complexes exhibiting metal- and ligand-based redox chemistry.

    PubMed

    Franks, Mark; Gadzhieva, Anastasia; Ghandhi, Laura; Murrell, David; Blake, Alexander J; Davies, E Stephen; Lewis, William; Moro, Fabrizio; McMaster, Jonathan; Schröder, Martin

    2013-01-18

    Five-coordinate Zn(II), Ni(II), and Cu(II) complexes containing pentadentate N(3)O(2) Schiff base ligands [1A](2-) and [1B](2-) have been synthesized and characterized. X-ray crystallographic studies reveal five coordinate structures in which each metal ion is bound by two imine N-donors, two phenolate O-donors, and a single amine N-donor. Electron paramagnetic resonance (EPR) spectroscopic studies suggest that the N(3)O(2) coordination spheres of [Cu(1A)] and [Cu(1B)] are retained in CH(2)Cl(2) solution and solid-state superconducting quantum interference device (SQUID) magnetometric studies confirm that [Ni(1A)] and [Ni(1B)] adopt high spin (S = 1) configurations. Each complex exhibits two reversible oxidation processes between +0.05 and +0.64 V vs [Fc](+)/[Fc]. The products of one- and two-electron oxidations have been studied by UV/vis spectroelectrochemistry and by EPR spectroscopy which confirm that each oxidation process for the Zn(II) and Cu(II) complexes is ligand-based with sequential formation of mono- and bis-phenoxyl radical species. In contrast, the one-electron oxidation of the Ni(II) complexes generates Ni(III) products. This assignment is supported by spectroelectrochemical and EPR spectroscopic studies, density functional theory (DFT) calculations, and the single crystal X-ray structure of [Ni(1A)][BF(4)] which contains Ni in a five-coordinate distorted trigonal bipyramidal geometry.

  20. DO GIANT PLANETS SURVIVE TYPE II MIGRATION?

    SciTech Connect

    Hasegawa, Yasuhiro; Ida, Shigeru E-mail: ida@geo.titech.ac.jp

    2013-09-10

    Planetary migration is one of the most serious problems to systematically understand the observations of exoplanets. We clarify that the theoretically predicted type II, migration (like type I migration) is too fast, by developing detailed analytical arguments in which the timescale of type II migration is compared with the disk lifetime. In the disk-dominated regime, the type II migration timescale is characterized by a local viscous diffusion timescale, while the disk lifetime is characterized by a global diffusion timescale that is much longer than the local one. Even in the planet-dominated regime where the inertia of the planet mass reduces the migration speed, the timescale is still shorter than the disk lifetime except in the final disk evolution stage where the total disk mass decays below the planet mass. This suggests that most giant planets plunge into the central stars within the disk lifetime, and it contradicts the exoplanet observations that gas giants are piled up at r {approx}> 1 AU. We examine additional processes that may arise in protoplanetary disks: dead zones, photoevaporation of gas, and gas flow across a gap formed by a type II migrator. Although they make the type II migration timescale closer to the disk lifetime, we show that none of them can act as an effective barrier for rapid type II migration with the current knowledge of these processes. We point out that gas flow across a gap and the fraction of the flow accreted onto the planets are uncertain and they may have the potential to solve the problem. Much more detailed investigation for each process may be needed to explain the observed distribution of gas giants in extrasolar planetary systems.

  1. Copper(II) thiaethyneporphyrin and copper(II) 21-phosphoryl N-confused porphyrin hybrids. intramolecular copper(II)-carbon interaction inside of a porphyrinoid surrounding.

    PubMed

    Grzegorzek, Norbert; Nojman, Elżbieta; Szterenberg, Ludmiła; Latos-Grażyński, Lechosław

    2013-03-01

    Stabilization of unusual organocopper(II) species via the very efficient protection of the copper(II)-carbon bond has been achieved encapsulating the copper(II) center in the coordination core of suitably constructed carbaporphyrinoids. Copper(II) was inserted into hybrid N-confused porphyrins which contain 21-diphenylphosphoryl-, 21-diphenylthiophosphoryl-, or 21-phosphinodithioic substituents or into 20-thiaethyneporphyrin, an aromatic porphyrinoid, which combines two structural motifs of 21-thiaporphyrin and ethyne. Two distinctly different types of the copper(II)-carbon bond have been detected. Copper(II) hybrid N-confused porphyrins reveal the η(1)-C(21) side-on coordination. The unprecedented equatorial metal(II)···η(2)-CC interaction has been trapped in a copper(II) thiaethyneporphyrin surrounding.

  2. Recycled chitosan nanofibril as an effective Cu(II), Pb(II) and Cd(II) ionic chelating agent: adsorption and desorption performance.

    PubMed

    Liu, Dagang; Li, Zehui; Zhu, Yi; Li, Zhenxuan; Kumar, Rakesh

    2014-10-13

    Mechanically disassembled chitosan nanofibrils were prepared and used as metal ion chelating agents. Structure and morphology of nanofibrils were investigated and ionic adsorption or desorption performance were validated to establish related fitting models. In single metal ion solution, the saturated adsorption capacities of Cu(II), Pb(II), Cd(II), Zn(II), and Ni(II) were 168.66, 118.00 and 60.85, 143.67, and 63.32 mg/g, respectively. In ternary metal ion solution, Cu(II) was more competitive to be adsorbed than Pb(II) and Cd(II) and its removal could arrive at 60%. Ions adsorbed by nanofibrils could be released by EDTA and the recovery could keep above 70% after 3 sorption-desorption cycles. Hence, renewable and recyclable nanofibrillar chitosan exhibited a great promising application in metal treatments attributed to its high adsorption capacity and chelation efficiency.

  3. Phase relations in the system NaCl-KCl-H2O II: Differential thermal analysis of the halite liquidus in the NaCl-H2O binary above 450°c

    USGS Publications Warehouse

    Gunter, W.D.; Chou, I.-Ming; Girsperger, Sven

    1983-01-01

    The solubility of halite can be expressed as a function of the mole-fractional-based activity of NaCl in the liquid phase (L) in temperature (T, °K) and pressure (P, bars) In  Our liquidus data (based on 10 compositions) above 500 bars for these brines were combined with this equation to generate activity coefficients of NaCl which were fit within their experimental uncertainties to the following one parameter Margules equation In . Concentrated solutions of NaCl show negative deviations from ideality which rapidly increase in magnitude with decreasing XNaCl.

  4. Site Environmental Report for 1998 Volume II

    SciTech Connect

    Ruggieri, Michael

    1999-09-30

    Volume II of the Site Environment Report for 1998 is provided by Ernest Orlando Lawrence Berkeley National Laboratory as a supplemental appendix to the report printed in volume I. Volume II contains the environmental monitoring and sampling data used to generate summary results in the main report for routine and non routine activities at the Laboratory (except for groundwater sampling data, which may be found in the reports referred to in chapter 6). Data presented in the tables are given in International System of Units (SI) units of measure.

  5. SLUDGE BATCH 6 PHASE II FLOWSHEET SIMULATIONS

    SciTech Connect

    Koopman, D.; Best, D.

    2010-03-30

    Two Sludge Receipt and Adjustment Tank (SRAT) runs were used to demonstrate that a fairly wide window of acid stoichiometry was available for processing SB6 Phase II flowsheet simulant (Tank 40 simulant) while still meeting the dual goals of acceptable nitrate destruction and controlled hydrogen generation. Phase II was an intermediate flowsheet study for the projected composition of Tank 40 after transfer of SB6/Tank 51 sludge to the heel of SB5. The composition was based on August 2009 projections. A window of about 50% in total acid was found between acceptable nitrite destruction and excessive hydrogen generation.

  6. trans-Bis(hexafluoroantimonato)(phthalocyaninato)copper(II).

    PubMed

    Gardberg, A S; Ibers, J A

    2001-05-01

    The title compound, trans-bis(hexafluoroantimonato-F)(phthalocyaninato-kappa(4)N(29,30,31,32))copper(II), [Cu(SbF(6))(2)(C(32)H(16)N(8))] or Cu(pc)(SbF(6))(2) (pc is phthalocyaninate), comprises a six-coordinate Cu atom, lying on an inversion center, bonded to four N atoms of a phthalocyanine ring and to F atoms of two trans SbF(6)(-) groups. The compound is presumed to consist of a Cu(II) center and a doubly oxidized phthalocyanine ring, by analogy with Cu(pc)(ReO(4))(2).

  7. TAURUS II launch vehicle lox subcooler

    NASA Astrophysics Data System (ADS)

    McIntosh, Glen E.

    2012-06-01

    The Orbital Sciences Taurus II medium lift launch vehicle utilizes first stage engines fueled by liquid oxygen and RP-1. Performance of the Taurus II is enhanced by densifying the liquid oxygen from a saturation temperature of 94 K to a subcooled temperature of 77.9 K. Subcooling the 75.07 kg/s liquid oxygen flow is accomplished in a 1.907 megawatt heat exchanger cooled by a flow of 9.62 kg/s ambient pressure liquid nitrogen. Design, fabrication, insulation and testing of the densification heat exchanger is described in this paper.

  8. CDF - Run II Status and Prospects

    SciTech Connect

    Manfred Paulini

    2003-03-17

    After a five year upgrade period, the CDF detector located at the Fermilab Tevatron Collider is back in operation taking high quality data with all subsystems functional. We report on the status of the CDF experiment in Run II and discuss the start-up of the Tevatron accelerator. First physics results from CDF are presented. We also discuss the prospects for B physics in RunII, in particular the measurements of B{sub S}{sup 0} flavour oscillations and CP violation in B decays.

  9. Touschek Lifetime Calculations for NSLS-II

    SciTech Connect

    Nash,B.; Kramer, S.

    2009-05-04

    The Touschek effect limits the lifetime for NSLS-II. The basic mechanism is Coulomb scattering resulting in a longitudinal momentum outside the momentum aperture. The momentum aperture results from a combination of the initial betatron oscillations after the scatter and the non-linear properties determining the resultant stability. We find that higher order multipole errors may reduce the momentum aperture, particularly for scattered particles with energy loss. The resultant drop in Touschek lifetime is minimized, however, due to less scattering in the dispersive regions. We describe these mechanisms, and present calculations for NSLS-II using a realistic lattice model including damping wigglers and engineering tolerances.

  10. Validation of SAGE II ozone measurements

    NASA Technical Reports Server (NTRS)

    Cunnold, D. M.; Chu, W. P.; Mccormick, M. P.; Veiga, R. E.; Barnes, R. A.

    1989-01-01

    Five ozone profiles from the Stratospheric Aerosol and Gas Experiment (SAGE) II are compared with coincident ozonesonde measurements obtained at Natal, Brazil, and Wallops Island, Virginia. It is shown that the mean difference between all of the measurements is about 1 percent and that the agreement is within 7 percent at altitudes between 20 and 53 km. Good agreement is also found for ozone mixing ratios on pressure surfaces. It is concluded that the SAGE II profiles provide useful ozone information up to about 60 km altitude.

  11. Comparison of TcPO II and StO II using the blood oxygen dissociation curve

    NASA Astrophysics Data System (ADS)

    Wright, Leigh P.; Makhratchev, Marina; Yarbrough, Amy; Elmandjra, Mohamed; Mao, Jian-min

    2006-02-01

    It is well known that the relation between the partial pressure of oxygen in blood (PO II) and the hemoglobin oxygen saturation in blood (SO II) is given by the oxyhemoglobin dissociation curve. In this study, we investigate if a similar relation exists in tissue. The PO II in tissue was approximated by the transcutaneous partial pressure of oxygen (TcPO II) measured by TCM3 TM Transcutanous pO II/pCO II Monitoring System; and the SO II in tissue (StO II) was measured by ODISsey TM Tissue Oximeter. The study showed that the TcPO II versus StO II relation is similar to the dissociation curve in blood, as expected.

  12. Synthesis, characterization and equilibrium studies of some potential antimicrobial and antitumor complexes of Cu(II), Ni(II), Zn(II) and Cd(II) ions involving 2-aminomethylbenzimidazole and glycine

    NASA Astrophysics Data System (ADS)

    Aljahdali, M.

    2013-08-01

    The ternary complexes of Cu(II), Zn(II), Ni(II) and Cd(II) with 2-aminomethylbenzimidazole (AMBI) and glycine as a representative example of amino acids have been isolated and characterized by elemental analyses, IR, ESR, UV-vis, magnetic moment, molar conductance and 1H NMR spectra. AMBI behaves as neutral bidentate ligands with coordination through imidazole and amino group nitrogens while the glycine amino acid behaves as a monodenate anion with coordination involving the amino group and carboxylate oxygen after deprotonation. The magnetic and spectral data indicates a square planar geometry for both Cu2+ and Ni2+ complexes and a tetrahedral geometry for both Zn2+ and Cd2+ complexes. The isolated chelates have been screened for their antifungal and antibacterial activities using the disc diffusion method. A cytotoxicity of the compounds against colon (HCT116) and larynx (HEP2) cancer cells have been studied. The stability constants of ternary M-AMBI-Gly complexes were determined potentiometrically in aqueous solution at I = 0.1 mol dm-3 NaCl.

  13. Ni(II) And Co(II) Sensing By Escherichia Coli RcnR

    SciTech Connect

    Iwig, J.S.; Leitch, S.; Herbst, R.W.; Maroney, M.J.; Chivers, P.T.

    2009-05-18

    Escherichia coli RcnR and Mycobacterium tuberculosis CsoR are the founding members of a recently identified, large family of bacterial metal-responsive DNA-binding proteins. RcnR controls the expression of the metal efflux protein RcnA only in response to Ni(II) and Co(II) ions. Here, the interaction of Ni(II) and Co(II) with wild-type and mutant RcnR proteins is examined to understand how these metals function as allosteric effectors. Both metals bind to RcnR with nanomolar affinity and stabilize the protein to denaturation. X-ray absorption and electron paramagnetic resonance spectroscopies reveal six-coordinate high-spin sites for each metal that contains a thiolate ligand. Experimental data support a tripartite N-terminal coordination motif (NH{sub 2}-Xaa-NH-His) that is common for both metals. However, the Ni(II)- and Co(II)-RcnR complexes are shown to differ in the remaining coordination environment. Each metal coordinates a conserved Cys ligand but with distinct M-S distances. Co(II)-thiolate coordination has not been observed previously in Ni(II)-/Co(II)-responsive metalloregulators. The ability of RcnR to recruit ligands from the N-terminal region of the protein distinguishes it from CsoR, which uses a lower coordination geometry to bind Cu(I). These studies facilitate comparisons between Ni(II)-RcnR and NikR, the other Ni(II)-responsive transcriptional regulator in E. coli, to provide a better understanding how different nickel levels are sensed in E. coli. The characterization of the Ni(II)- and Co(II)-binding sites in RcnR, in combination with bioinformatics analysis of all RcnR/CsoR family members, identified a four amino acid fingerprint that likely defines ligand-binding specificity, leading to an emerging picture of the similarities and differences between different classes of RcnR/CsoR proteins.

  14. The VLT/NaCo large program to probe the occurrence of exoplanets and brown dwarfs at wide orbits. II. Survey description, results, and performances

    NASA Astrophysics Data System (ADS)

    Chauvin, G.; Vigan, A.; Bonnefoy, M.; Desidera, S.; Bonavita, M.; Mesa, D.; Boccaletti, A.; Buenzli, E.; Carson, J.; Delorme, P.; Hagelberg, J.; Montagnier, G.; Mordasini, C.; Quanz, S. P.; Segransan, D.; Thalmann, C.; Beuzit, J.-L.; Biller, B.; Covino, E.; Feldt, M.; Girard, J.; Gratton, R.; Henning, T.; Kasper, M.; Lagrange, A.-M.; Messina, S.; Meyer, M.; Mouillet, D.; Moutou, C.; Reggiani, M.; Schlieder, J. E.; Zurlo, A.

    2015-01-01

    Context. Young, nearby stars are ideal targets for direct imaging searches for giant planets and brown dwarf companions. After the first-imaged planet discoveries, vast efforts have been devoted to the statistical analysis of the occurence and orbital distributions of giant planets and brown dwarf companions at wide (≥5-6 AU) orbits. Aims: In anticipation of the VLT/SPHERE planet-imager, guaranteed-time programs, we have conducted a preparatory survey of 86 stars between 2009 and 2013 to identify new faint comoving companions to ultimately analyze the occurence of giant planets and brown dwarf companions at wide (10-2000 AU) orbits around young, solar-type stars. Methods: We used NaCo at VLT to explore the occurrence rate of giant planets and brown dwarfs between typically 0.1 and 8''. Diffraction-limited observations in H-band combined with angular differential imaging enabled us to reach primary star-companion brightness ratios as small as 10-6 at 1.5''. Repeated observations at several epochs enabled us to discriminate comoving companions from background objects. Results: During our survey, twelve systems were resolved as new binaries, including the discovery of a new white dwarf companion to the star HD 8049. Around 34 stars, at least one companion candidate was detected in the observed field of view. More than 400 faint sources were detected; 90% of them were in four crowded fields. With the exception of HD 8049 B, we did not identify any new comoving companions. The survey also led to spatially resolved images of the thin debris disk around HD 61005 that have been published earlier. Finally, considering the survey detection limits, we derive a preliminary upper limit on the frequency of giant planets for the semi-major axes of [10, 2000] AU: typically less than 15% between 100 and 500 AU and less than 10% between 50 and 500 AU for exoplanets that are more massive than 5 MJup and 10 MJup respectively, if we consider a uniform input distribution and a

  15. Nickel(II) biosorption from aqueous solutions by shrimp head biomass.

    PubMed

    Hernández-Estévez, Alejandro; Cristiani-Urbina, Eliseo

    2014-11-01

    The present study evaluates the capacity of shrimp (Farfantepenaeus aztecus) head to remove toxic Ni(II) ions from aqueous solutions. Relevant parameters that could affect the biosorption process, such as shrimp head pretreatment, solution pH level, contact time and initial Ni(II) concentration, were studied in batch systems. An increase in Ni(II) biosorption capacity and a reduction in the time required to reach Ni(II) biosorption equilibrium was manifested by shrimp head biomass pretreated by boiling in 0.5 N NaOH for 15 min; this biomass was thereafter denominated APSH. The optimum biosorption level of Ni(II) ions onto APSH was observed at pH 7.0. Biosorption increased significantly with rising initial Ni(II) concentration. In terms of biosorption dynamics, the pseudo-second-order kinetic model described Ni(II) biosorption onto APSH best. The equilibrium data adequately fitted the Langmuir isotherm model within the studied Ni(II) ion concentration range. According to this isotherm model, the maximum Ni(II) biosorption capacity of APSH was 104.22 mg/g. Results indicate that APSH could be used as a low-cost, environmentally friendly, and promising biosorbent with high biosorption capacity to remove Ni(II) from aqueous solutions.

  16. Efficacy of modified distillation sludge of rose (Rosa centifolia) petals for lead(II) and zinc(II) removal from aqueous solutions.

    PubMed

    Nasir, Mubashir Hussain; Nadeem, Raziya; Akhtar, Kalsoom; Hanif, Muhammad Asif; Khalid, Ahmad M

    2007-08-25

    Removal of lead(II) and zinc(II) from aqueous solutions was studied using chemically modified distillation sludge of rose (Rosa centifolia) petals by pretreatment with NaOH, Ca(OH)(2), Al(OH)(3), C(6)H(6), C(6)H(5)CHO and HgCl(2). The adsorption capacity of biomass was found to be significantly improved. NaOH pretreated biomass showed remarkable increase in sorption capacity. Maximum adsorption of both metal ions was observed at pH 5. When Freundlich and Langmuir isotherms were tested, the latter had a better fit with the experimental data. The overall adsorption process was best described by pseudo second order kinetics. The thermodynamic assessment of the metal ion-Rosa centifolia biomass system indicated the feasibility and spontaneous nature of the process and DeltaG degrees was evaluated as ranging from -26.9501 to -31.652 KJmol(-1) and -24.1905 to -29.8923KJmol(-1) for lead(II) and zinc(II) sorption, respectively, in the concentration range 10-640mgL(-1). Distribution coefficient (D) showed that the concentration of metal ions at the sorbent-water interface is higher than the concentration in the continuous aqueous phase. Maximum adsorption capacity of biomass tends to be in the order Pb(II) (87.74mgg(-1))>Zn(II) (73.8mgg(-1)) by NaOH pretreated biomass.

  17. Spectroscopic (FT-IR, FT-Raman, 1H, 13C NMR, UV/VIS), thermogravimetric and antimicrobial studies of Ca(II), Mn(II), Cu(II), Zn(II) and Cd(II) complexes of ferulic acid

    NASA Astrophysics Data System (ADS)

    Kalinowska, M.; Piekut, J.; Bruss, A.; Follet, C.; Sienkiewicz-Gromiuk, J.; Świsłocka, R.; Rzączyńska, Z.; Lewandowski, W.

    2014-03-01

    The molecular structure of Mn(II), Cu(II), Zn(II), Cd(II) and Ca(II) ferulates (4-hydroxy-3-methoxycinnamates) was studied. The selected metal ferulates were synthesized. Their composition was established by means of elementary and thermogravimetric analysis. The following spectroscopic methods were used: infrared (FT-IR), Raman (FT-Raman), nuclear magnetic resonance (13C, 1H NMR) and ultraviolet-visible (UV/VIS). On the basis of obtained results the electronic charge distribution in studied metal complexes in comparison with ferulic acid molecule was discussed. The microbiological study of ferulic acid and ferulates toward Escherichia coli, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus and Proteus vulgaris was done.

  18. Biosorption characteristics of copper (II), chromium (III), nickel (II), and lead (II) from aqueous solutions by Chara sp. and Cladophora sp.

    PubMed

    Elmaci, Ayşe; Yonar, Taner; Ozengin, Nihan

    2007-09-01

    The aim of this research was to expose individual removals of copper, chromium, nickel, and lead from aqueous solutions via biosorption using nonliving algae species, Chara sp. and Cladophora sp. Optimum pH values for biosorption of copper (II), chromium (III), nickel (II), and lead (II) from aqueous solutions were determined to be 6, 7, 7, and 3 for Cladophora sp. and 5, 3, 5, and 4 for Chara sp. respectively. Maximum adsorption capacities of Chara sp. [10.54 for chromium (III) and 61.72 for lead (II)] and Cladophora sp. [6.59 for chromium (III) and 16.75 and 23.25 for lead (II)] for chromium (III) and lead (II) are similar. On the other hand, copper (II) and nickel (II) biosorption capacity of Cladophora sp. [14.28 for copper (II) and 16.75 for nickel (II)] is greater than Chara sp. [6.506 for copper (II) and 11.76 for nickel (II)]. Significantly high correlation coefficients indicated for the Langmuir adsorption isotherm models can be used to describe the equilibrium behavior of copper, chromium, nickel, and lead adsorption onto Cladophora sp. and Chara sp.

  19. Electroanalytical investigation on the interaction between 6-mercaptopurine and zinc(II), lead(II), and cadmium(II) ions in nonaqueous solvents.

    PubMed

    Cinquantini, A; Cini, R; Zanello, P

    1980-04-01

    Different electroanalytical techniques have been employed in the study of the interaction between 6-mercaptopurine and zinc(II), lead(II), and cadmium(II) ions in ethanol, dimethylformamide, and dimethylsulfoxide. The stoichiometry of the formed complexes was determined as well as their instability constants. The kinetic parameters of the electrode processes have been also evaluated.

  20. Competitive adsorption of Cu (II), Co (II) and Ni (II) from their binary and tertiary aqueous solutions using chitosan-coated perlite beads as biosorbent.

    PubMed

    Swayampakula, Kalyani; Boddu, Veera M; Nadavala, Siva Kumar; Abburi, Krishnaiah

    2009-10-30

    A new composite chitosan-coated biosorbent was prepared and was used for the removal and recovery of heavy metals from aqueous solution. In the present investigation, equilibrium adsorption characteristics of Cu (II), Ni (II), and Co (II) from their binary and tertiary solution on newly developed biosorbent chitosan-coated perlite beads were evaluated through batch and column studies. These beads were characterized by using FTIR, EDXRF and surface area analysis techniques. The effect of various biosorption parameters like effect of pH, agitation time, concentration of adsorbate and amount of adsorbent on extent of adsorption was investigated. The adsorption follows Lagergren first order kinetic model. The equilibrium adsorption data were fitted to Freundlich and Langmuir adsorption isotherm models and the model parameters were evaluated. Both the models represent the experimental data satisfactorily. The sorbent loaded with metal was regenerated with 0.1N NaOH solution. Furthermore the column dynamic studies indicate the re-usage of the biosorbent.

  1. [Evaluation of serum PIVKA-II by Lumipulse PrestoII assay].

    PubMed

    Hiramatsu, Kumiko; Tanaka, Yasuhito; Takagi, Kazumi; Kani, Satomi; Goto, Takaaki; Takasaka, Yoshimitsu; Matsuura, Kentaro; Sugauchi, Fuminaka; Moriyama, Kazushige; Murakami, Hiroshi; Kitajima, Sachiko; Mizokami, Masashi

    2009-03-01

    Measurements of serum concentrations of Des-gamma-carboxy Prothrombin (PIVKA-II) are widely used for diagnosing hepatocellular carcinoma (HCC). Recently, in Lumipulsef assay, it was reported that antibodies against alkaline phosphatase (ALP) derived from anti bleeding sheets led false high values of PIVKA-II in the patients with HCC resection. To improve the previous issue, newly developed Lumipulse PrestoII assay was examined. (1) The assay was reliable and positively correlated with the previous assays (Lumipulse f and Picolumi, R = 0.997 and 0.994 (n=115), respectively). (2) Eleven cases, which had false high values of PIVKA-II by the Lumipulsef assay, were examined by the PrestoII assay with excess of inactive ALP. The false high values of 10 cases were improved, but only one was still high. False reactivity of this case was stronger than other cases, more effective adsorption was required. (3) Comparing the absorbent activity of inactive ALP among 6 different kinds, we found inactive ALP with much higher adsorbent activity. When this inactive ALP was applied to assay, false high values of PIVKA-II were improved in all 11 cases. In conclusion, the PrestoII assay, which applies the inactive ALP with high activity, is reliable and useful for clinical screening.

  2. Predicting outcomes in organophosphate poisoning based on APACHE II and modified APACHE II scores.

    PubMed

    Eizadi-Mood, N; Saghaei, M; Jabalameli, M

    2007-07-01

    The aim of this study was to evaluate the scores of the Acute Physiology and Chronic Health Evaluation (APACHE) II and a modified APACHE II system (MAS), without parameters of biochemical tests; and to find prognostic value of individual elements of the APACHE II and MAS in predicting outcomes in organophosphate (OP) poisoning. Data were collected from 131 patients. The median (25th-75th percentiles) of APACHE II score for survivors without intubation were found to be lower than those of non survivors or survivors with intubation and ventilation, [4 (1-7); versus 17.5 (7.8-29), and 13.5 (7.8-16.3)]. Logistic regression analysis identified white blood cell (WBC), potassium, Glasgow coma scale (GCS), age and sodium in APACHE II; GCS and mean arterial pressure in MAS system as prognostically valuable. There was no statistically significance difference between APACHE II and MAS scores in terms of area under Receiver Operating Characteristic Curve [(0.902, 95% confidence interval: (0.837-0.947) for APACHE II), and (0.892, 95% confidence interval: (0.826-0.940) for MAS); P=0.74) to predict need for intubation. It is concluded usage of MAS facilitates the prognostication of the OP poisoned patients due to simplicity, less time-consuming and effectiveness in an emergency situation.

  3. Lifetimes and Oscillator Strengths for Ultraviolet Transitions in P II, Cl II and Cl III

    NASA Technical Reports Server (NTRS)

    Cheng, S.; Federman, S. R.; Schectman, R. M.; Brown, M.; Irving, R. E.; Fritts, M. C.; Gibson, N. D.

    2006-01-01

    Oscillator strengths for transitions in P II, Cl II and Cl III are derived from lifetimes and branching factions measured with beam-foil techniques. The focus is on the multiplets with a prominent interstellar line at 1153 A in P II which is seen in spectra of hot stars, and the lines at 1071 A in Cl II and 1011 A in Cl III whose lines are seen in spectra of diffuse interstellar clouds and the Io torus acquired with the Far Ultraviolet Spectroscopic Explorer. These data represent the first complete set of experimental f-values for the lines in the multiplets. Our results for P II (lambda)1153 agree well with Curtis semi-empirical predictions, as well as the large scale computations by Hibbert and by Tayal. The data for Cl II (lambda)1071 also agree very well with the most recent theoretical effort and with Morton s newest recommendations. For Cl III, however, our f-values are significantly larger than those given by Morton; instead, they are more consistent with recent large-scale theoretical calculations. Extensive tests provide confirmation that LS coupling rules apply to the transitions for the multiplets in Cl II and Cl III.

  4. Copper(II) and nickel(II) binding sites of peptide containing adjacent histidyl residues.

    PubMed

    Grenács, Ágnes; Sanna, Daniele; Sóvágó, Imre

    2015-10-01

    Copper(II) and nickel(II) complexes of the terminally protected nonapeptide Ac-SGAEGHHQK-NH2 modeling the metal binding sites of the (8-16) domain of amyloid-β have been studied by potentiometric, UV-vis, CD and ESR spectroscopic methods. The studies on the mutants containing only one of the histidyl residues (Ac-SGAEGAHQK-NH2, Ac-SGAEGHAQK-NH2) have also been performed. The formation of imidazole and amide coordinated mononuclear complexes is characteristic of all systems with a preference of nickel(II) binding to the His14 site, while the involvement of both histidines in metal binding is suggested in the corresponding copper(II) complexes. The formation of bis(ligand) and dinuclear complexes has also been observed in the copper(II)-Ac-SGAEGHHQK-NH2 system. The results provide further support for the copper(II) binding ability of the (8-16) domain of amyloid-β and support the previous assumptions that via the bis(ligand) complex formation copper(II) ions may promote the formation of the oligomers of amyloid-β.

  5. THE GREEN BANK TELESCOPE H II REGION DISCOVERY SURVEY. II. THE SOURCE CATALOG

    SciTech Connect

    Anderson, L. D.; Bania, T. M.; Balser, Dana S.; Rood, Robert T.

    2011-06-01

    The Green Bank Telescope (GBT) H II Region Discovery Survey has doubled the number of known H II regions in the Galactic zone 343{sup 0} {<=} l {<=} 67{sup 0} with | b | {<=} 1{sup 0}. We detected 603 discrete hydrogen radio recombination line (RRL) components at 9 GHz (3 cm) from 448 targets. Our targets were selected based on spatially coincident mid-infrared and 20 cm radio continuum emission. Such sources are almost invariably H II regions; we detected hydrogen RRL emission from 95% of our target sample. The sensitivity of the GBT and the power of its spectrometer together made this survey possible. Here, we provide a catalog of the measured properties of the RRL and continuum emission from the survey nebulae. The derived survey completeness limit, 180 mJy at 9 GHz, is sufficient to detect all H II regions ionized by single O-stars to a distance of 12 kpc. These recently discovered nebulae share the same distribution on the sky as does the previously known census of Galactic H II regions. On average, however, the new nebulae have fainter continuum fluxes, smaller continuum angular sizes, fainter RRL intensities, and smaller RRL line widths. Though small in angular size, many of our new nebulae show little spatial correlation with tracers associated with extremely young H II regions, implying that our sample spans a range of evolutionary states. We discovered 34 first quadrant negative-velocity H II regions, which lie at extreme distances from the Sun and appear to be part of the Outer Arm. We found RRL emission from 208 Spitzer GLIMPSE 8.0 {mu}m 'bubble' sources, 65 of which have been cataloged previously. It thus appears that nearly all GLIMPSE bubbles are H II regions and that {approx}50% of all Galactic H II regions have a bubble morphology at 8.0 {mu}m.

  6. Solvent Refined Coal-II (SRC-II) detailed environmental plan

    SciTech Connect

    Not Available

    1980-10-01

    This document describes environmental research which will: aid in the development of an environmentally acceptable SRC-II process; and provide data for environmental assessment of the process. The SRC-II process is described, criteria for selection of samples to undergo environmental analyses are given, and approximate timelines are presented for obtaining pertinent samples. At this time, the SRC-II process is at the pilot-plant stage of development and a demonstration facility is scheduled to begin operation in 1984. Since design criteria may change, the environmental research described in this document is organized in four phases which correlate with and will provide information early in process development. Phase I research (screening) evaluates samples from existing SRC-II facilities (pilot, process demonstration unit (PDU), bench) which may bracket potential demonstration/commercial practice in terms of physical and chemical criteria. The samples are being subjected to a battery of short-term biomedical and ecological assays. Chemical fractionation and analysis are being performed to determine compounds and compound classes of potential concern. Phase II (baseline) research will evaluate SRC-II materials which are considered most representative of potential demonstration/commercial practice. These materials will be subjected to longer-term, more-extensive biological and ecological analyses relative to effects and environmental fate. Phase III research will examine effects of process modification, control technologies and changing operational conditions on potential environmental properties of SRC-II materials. Phase IV research (onsite monitoring) will develop methods and initiate environmental monitoring for effects at the SRC-II demonstration facility and potential commercial sites. This document also describes industrial hygiene programs which must occur throughout SRC-II process development.

  7. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression

    PubMed Central

    Leung, Chi Ming; Yim, Chi Lap; Yan, Connie T. Y.; Chan, Cheuk Chi; Xiang, Yu-Tao; Mak, Arthur D. P.; Fok, Marcella Lei-Yee; Ungvari, Gabor S.

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8%) were males and 233 (78.2%) females. There were 112 (37.6%) subjects with BP depression [BP-I = 42 (14.1%), BP-II = 70 (23.5%)] and 182 (62.4%) with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results. PMID:26963908

  8. Ultraviolet Emission Lines of Si ii in Quasars: Investigating the "Si ii Disaster"

    NASA Astrophysics Data System (ADS)

    Laha, Sibasish; Keenan, Francis P.; Ferland, Gary J.; Ramsbottom, Catherine A.; Aggarwal, Kanti M.

    2016-07-01

    The observed line intensity ratios of the Si ii λ1263 and λ1307 multiplets to that of Si ii λ1814 in the broad-line region (BLR) of quasars are both an order of magnitude larger than the theoretical values. This was first pointed out by Baldwin et al., who termed it the “Si ii disaster,” and it has remained unresolved. We investigate the problem in the light of newly published atomic data for Si ii. Specifically, we perform BLR calculations using several different atomic data sets within the CLOUDY modeling code under optically thick quasar cloud conditions. In addition, we test for selective pumping by the source photons or intrinsic galactic reddening as possible causes for the discrepancy, and we also consider blending with other species. However, we find that none of the options investigated resolve the Si ii disaster, with the potential exception of microturbulent velocity broadening and line blending. We find that a larger microturbulent velocity (˜ 500 {km} {{{s}}}-1) may solve the Si ii disaster through continuum pumping and other effects. The CLOUDY models indicate strong blending of the Si ii λ1307 multiplet with emission lines of O i, although the predicted degree of blending is incompatible with the observed λ1263/λ1307 intensity ratios. Clearly, more work is required on the quasar modeling of not just the Si ii lines but also nearby transitions (in particular those of O i) to fully investigate whether blending may be responsible for the Si ii disaster.

  9. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression.

    PubMed

    Leung, Chi Ming; Yim, Chi Lap; Yan, Connie T Y; Chan, Cheuk Chi; Xiang, Yu-Tao; Mak, Arthur D P; Fok, Marcella Lei-Yee; Ungvari, Gabor S

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8%) were males and 233 (78.2%) females. There were 112 (37.6%) subjects with BP depression [BP-I = 42 (14.1%), BP-II = 70 (23.5%)] and 182 (62.4%) with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results. PMID:26963908

  10. Geochemical dynamics of the Atlantis II Deep (Red Sea): II. Composition of metalliferous sediment pore waters

    NASA Astrophysics Data System (ADS)

    Anschutz, Pierre; Blanc, Gérard; Monnin, Christophe; Boulègue, Jacques

    2000-12-01

    The Atlantis II Deep is an axial depression of the Red Sea filled with highly saline brines and covered by layered metalliferous sediment. We report new data on the vertical distribution of major salts and trace metals dissolved in the pore waters of the metalliferous sediments. We have studied the chemical composition of interstitial waters of two sediment cores of the western (core 684) and southwestern (core 683) basins. The major dissolved elements are Na and Cl. Their concentrations are close to those of the brine overlying the sediment. The pore waters are undersaturated with respect to halite at the in situ conditions (62°C, 220 bars), but are saturated at the shipboard conditions (10°C, 1 bar). The salt and water contents of the bulk sediment show that core 683 contained halite in the solid fraction. A part of it precipitated after core collection, but most of it was present in situ. Thermodynamic calculations with a water-rock interaction model based on Pitzer's ion interaction approach reveal that equilibrium between the pore waters and anhydrite is achieved in sediment layers for which observations report the presence of this mineral. We used a transport model, which shows that molecular diffusion can smooth the profile of dissolved salt and partly erase the pore water record of past variations of salinity in the lower brine. For example, we calculated that the pore water record of modern variation of brine salinity is rapidly smoothed by molecular diffusion. The dissolved transition metals show large variations with depth in the interstitial waters. The profiles of core 683 reflect the possible advection of hydrothermal fluid within the sediment of the southwestern basin. The distribution of dissolved metals in core 684 is the result of diagenetic reactions, mainly the reduction of Mn-oxide with dissolved Fe(II), the recrystallization of primary oxide minerals, and the precipitation of authigenic Mn-carbonates.

  11. Chemotherapy for Stage II Colon Cancer.

    PubMed

    Varghese, Anna

    2015-12-01

    The adjuvant treatment of patients with stage II colon cancer is an area of controversy in medical oncology. Adjuvant chemotherapy aims to eradicate micrometastatic disease present at the time of surgery, preventing the development of distant metastatic disease and thereby curing those patients of their cancer. National and international guidelines for the adjuvant treatment of stage II colon cancer recommend a range of treatment options from observation to chemotherapy with single-agent or combination regimens, depending on the presence or absence of high-risk features (poorly differentiated histology, presence of lymphovascular invasion, presence of perineural invasion, report of < 12 lymph nodes, bowel obstruction, localized perforation, or positive margins). In the one prospective study designed to address the role of adjuvant chemotherapy in stage II colon cancer, a small but statistically significant benefit in overall survival was seen for those patients who received adjuvant chemotherapy; however, multiple meta-analyses and retrospective subgroup analyses have called these findings into question. Though there may be a role for adjuvant chemotherapy in the treatment of patients with stage II colon cancer, its incremental benefit is small, at best, and comes with the risks of real and rarely fatal complications of chemotherapy. PMID:26648796

  12. Database for bacterial group II introns.

    PubMed

    Candales, Manuel A; Duong, Adrian; Hood, Keyar S; Li, Tony; Neufeld, Ryan A E; Sun, Runda; McNeil, Bonnie A; Wu, Li; Jarding, Ashley M; Zimmerly, Steven

    2012-01-01

    The Database for Bacterial Group II Introns (http://webapps2.ucalgary.ca/~groupii/index.html#) provides a catalogue of full-length, non-redundant group II introns present in bacterial DNA sequences in GenBank. The website is divided into three sections. The first section provides general information on group II intron properties, structures and classification. The second and main section lists information for individual introns, including insertion sites, DNA sequences, intron-encoded protein sequences and RNA secondary structure models. The final section provides tools for identification and analysis of intron sequences. These include a step-by-step guide to identify introns in genomic sequences, a local BLAST tool to identify closest intron relatives to a query sequence, and a boundary-finding tool that predicts 5' and 3' intron-exon junctions in an input DNA sequence. Finally, selected intron data can be downloaded in FASTA format. It is hoped that this database will be a useful resource not only to group II intron and RNA researchers, but also to microbiologists who encounter these unexpected introns in genomic sequences.

  13. Site Environmental Report for 2008, Volume II

    SciTech Connect

    Lackner, Regina; Baskin, David; Fox, Robert; Jelinski, John; Pauer, Ron; Thorson, Patrick; Wahl, Linnea; Xu, Suying

    2009-09-21

    The Site Environmental Report for 2008 is an integrated report on environmental programs at Lawrence Berkeley National Laboratory and satisfies the requirements of DOE Order 231.1 A., Environment, Safety, and Health Reporting. Volume II contains individual data results from surveillance and monitoring activities

  14. Site Environmental Report for 2007 Volume II

    SciTech Connect

    Lackner, Regina E; Baskin, David; Fox, Robert; Jelinski, John; Pauer, Ron; Thorson, Patrick; Wahl, Linnea; Wyrick, Steve

    2008-09-15

    The Site Environmental Report for 2007 is an integrated report on the environmental programs at Lawrence Berkeley National Laboratory and satisfies the requirements of DOE Order 231.1A, Environment, Safety, and Health Reporting. Volume II contains individual data results from surveillance and monitoring activities.

  15. Microbunching phenomena in LCLS-II

    SciTech Connect

    Venturini, M.; Qiang, J.; Papadopoulos, C.; Ding, Y.; Emma, P.; Huang, Z.; Marcus, G.; Marinelli, A.; Nosochkov, Y.; Raubenheimer, T.; Wang, L.; Woodley, M.

    2015-07-14

    The microbunching instability has long been recognized as a potential limiting factor to the performance of X-ray FELs. It is of particular relevance in LCLS-II due, in part, to a layout that includes a long bypass beamline between the Linac and the undulators. Here we focus on two aspects of the instability that highlight the importance of 3D effects.

  16. RTNS-II 1984 annual report

    SciTech Connect

    Not Available

    1984-01-01

    RTNS-II was built to provide a deuterium-tritium neutron source for the study of fusion neutron effects. In the quest to apply fusion to commercial power production, the specific mission of RTNS-II is threefold: to acquire direct engineering data for near-term confinement experiments and for materials that will see moderate neutron dose in future reactor systems; to measure production rates of transmutants and to develop appropriate radiation-resistant instrumentation for fusion systems; and to study the radiation-induced property changes caused by fusion neutrons. RTNS-II comprises two independent sources of 14-MeV neutrons. This is the third annual report summarizing irradiation experiments at RTNS-II. It covers calendar year 1983, and includes reports of all irradiation results, both fusion and non-fusion related. These comprise both secondary (or ''add-on'') and primary irradiations. Each summary article has been submitted by the investigator and has been altered only to meet the style and format requirements of this report.

  17. Ir Spectroscopy and Nickel (II) Hexammines

    ERIC Educational Resources Information Center

    Reedijk, J.; And Others

    1975-01-01

    Describes an experiment, for the general chemistry laboratory, intended to introduce the student to infrared spectroscopy. After being introduced to the theory of molecular vibrations on an elementary level, each student receives a list of 5-7 nickel (II) ammines to be prepared, analyzed and characterized by infrared spectoscopy. (MLH)

  18. A movie of RNA polymerase II transcription.

    PubMed

    Cheung, Alan C M; Cramer, Patrick

    2012-06-22

    We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

  19. Theory of Aircraft Flight. Aerospace Education II.

    ERIC Educational Resources Information Center

    Elmer, James D.

    This revised textbook, one in the Aerospace Education II series, provides answers to many questions related to airplanes and properties of air flight. The first chapter provides a description of aerodynamic forces and deals with concepts such as acceleration, velocity, and forces of flight. The second chapter is devoted to the discussion of…

  20. Report of Programme Commission II (Natural Sciences).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). General Conference.

    As the first part of the report of the Programme Commission II, a summary of discussions on plans for natural sciences and their applications is presented in this document. The two agenda items are: (1) detailed consideration of the 1973-74 draft program and budget and of the 1973-78 draft medium-term outline, and (2) desirability of adopting an…

  1. H II Regions in Interacting Galaxies

    NASA Astrophysics Data System (ADS)

    Frattare, L. M.; Keel, W. C.; Laurikainen, E.

    1993-12-01

    We present a census of H II regions in 50 pairs of interacting galaxies, carried out on CCD and ISIT narrow-band images from Kitt Peak, Lowell, and La Palma. Objects were identified objectively using peak finding at multiple Gaussian smoothing levels to allow for the fact that the larger H II regions are marginally resolved, and measured using aperture photometry. We consider statistics of the space distribution, radial distribution, and luminosity functions. Preliminary analysis shows that the enhancement in star formation is strongest not only in the nuclear regions, but in preferred annuli as well. Interactions can produce significant asymmetries in the star-formation distribution. Some interacting galaxies show flatter luminosity functions for H II regions than seen in normal galaxies, either through an excess of very luminous star-forming complexes or a change in their clumping properties. We compare the statistics of both the location and luminosity of H II regions in interacting systems to results on isolated spirals. This work was supported by the NSF through REU grant AST-9300413 and EPSCoR grant EHR-9108761.

  2. NSLS-II RF BEAM POSITION MONITOR

    SciTech Connect

    Vetter, K.; Della Penna, A. J.; DeLong, J.; Kosciuk, B.; Mead, J.; Pinayev, I.; Singh, O.; Tian, Y.; Ha, K.; Portmann, G.; Sebek J.

    2011-03-28

    An internal R&D program has been undertaken at BNL to develop a sub-micron RF Beam Position Monitor (BPM) for the NSLS-II 3rd generation light source that is currently under construction. The BPM R&D program started in August 2009. Successful beam tests were conducted 15 months from the start of the program. The NSLS-II RF BPM has been designed to meet all requirements for the NSLS-II Injection system and Storage Ring. Housing of the RF BPM's in +-0.1 C thermally controlled racks provide sub-micron stabilization without active correction. An active pilot-tone has been incorporated to aid long-term (8hr min) stabilization to 200nm RMS. The development of a sub-micron BPM for the NSLS-II has successfully demonstrated performance and stability. Pilot Tone calibration combiner and RF synthesizer has been implemented and algorithm development is underway. The program is currently on schedule to start production development of 60 Injection BPM's starting in the Fall of 2011. The production of {approx}250 Storage Ring BPM's will overlap the Injection schedule.

  3. Day Camp Manual: Staff. Book II.

    ERIC Educational Resources Information Center

    Babcock, William

    Book II of a 5-book day camp manual focuses on staff selection and training. Following the philosophy that developing an effective staff is the responsibility of the camp director, the book contains major sections on staff recruitment (sources of staff, problems, selection procedures, job descriptions, personnel practices); guidelines for job…

  4. Status of the CDF II Calorimeters

    SciTech Connect

    Mattson, Mark

    2006-10-27

    The status of the CDF calorimeters was reported at the CALOR2002 conference, about a year after Run II started at the Tevatron Collider. I will review upgrades to the system since that conference, as well as the operation and performance of the calorimeters.

  5. Electrochemical Determination of Bisphenol A with Pencil Graphite Electrodes Modified with Co(II), Ni(II), Cu(II) and Fe(II) Phthalocyaninetetrasulfonates.

    PubMed

    Özcan, Levent; Altuntas, Muhammet; Büyüksagis, Aysel; Türk, Hayrettin; Yurdakal, Sedat

    2016-01-01

    Pencil graphite electrodes modified with Co(II), Ni(II), Cu(II) and Fe(II) metallophthalocyaninetetrasulfonates (MePcTSs) were investigated for an electrochemical determination of bisphenol A (BPA). The electrochemical performances of the modified electrodes for different pH values in phosphate and the Britton-Robinson buffers were determined by cyclic voltammetry; the electrode performances were better in the Britton-Robinson buffer. NiPcTS and CoPcTS modifications of the electrodes had remarkable enhancements on their performances. The differential pulse voltammetry parameters for the electrodes were optimized, and we found that the electrochemical response versus the concentration of BPA is linear from 5.0 × 10(-7) to 1.0 × 10(-5) M for the NiPcTS and CoPcTS modified electrodes. The detection limits of these modified electrodes are 2.9 × 10(-7) and 4.3 × 10(-7) M, respectively, and the effects of interfering species are less than 5%. The results show that NiPcTS and CoPcTS modified pencil graphite electrodes could be used for electrochemical determinations of BPA for analytical purposes. PMID:27506715

  6. The Uptake Mechanism of Cd(II), Cr(VI), Cu(II), Pb(II), and Zn(II) by Mycelia and Fruiting Bodies of Galerina vittiformis

    PubMed Central

    Damodaran, Dilna; Balakrishnan, Raj Mohan; Shetty, Vidya K.

    2013-01-01

    Optimum concentrations of heavy metals like copper, cadmium, lead, chromium, and zinc in soil are essential in carrying out various cellular activities in minimum concentrations and hence help in sustaining all life forms, although higher concentration of these metals is lethal to most of the life forms. Galerina vittiformis, a macrofungus, was found to accumulate these heavy metals into its fleshy fruiting body in the order Pb(II) > Cd(II) > Cu(II) > Zn(II) > Cr(VI) from 50 mg/kg soil. It possesses various ranges of potential cellular mechanisms that may be involved in detoxification of heavy metals and thus increases its tolerance to heavy metal stress, mainly by producing organic acids and phytochelatins (PCs). These components help in repairing stress damaged proteins and compartmentalisation of metals to vacuoles. The stress tolerance mechanism can be deduced by various analytical tools like SEM-EDX, FTIR, and LC-MS. Production of two kinds of phytochelatins was observed in the organism in response to metal stress. PMID:24455671

  7. Biceps Tenodesis for Type II SLAP Tears.

    PubMed

    Tayrose, Gregory A; Karas, Spero G; Bosco, Joseph

    2015-06-01

    Tears of the superior glenoid labrum are a common cause of shoulder pain and disability, especially in overhead athletes such as pitchers, swimmers, and volleyball players. Type II SLAP lesions have been the most clinically important superior labral pathology, and the management of this lesion has been a very controversial topic. Currently, there are no high level studies in the literature to guide treatment. While the few level 3 and level 4 evidence studies that are available following arthroscopic repair of type II SLAP lesions all report reasonable overall patient satisfaction, persistent postoperative pain is common and associated with a low return to pre-injury level of sports participation. There has been a recent school of thought that biceps tenodesis, which maintains the length-tension relationship of the long head of biceps, should be the procedure of choice for patients with isolated type II SLAP lesions. The current paper reviews the role biceps tenodesis plays in the management of type II SLAP tears. PMID:26517164

  8. Internet Image Viewer (iiV)

    PubMed Central

    Lee, Joel T; Munch, Kristin R; Carlis, John V; Pardo, José V

    2008-01-01

    Background Visualizing 3-dimensional (3-D) datasets is an important part of modern neuroimaging research. Many tools address this problem; however, they often fail to address specific needs and flexibility, such as the ability to work with different data formats, to control how and what data are displayed, to interact with values, and to undo mistakes. Results iiV, an interactive software program for displaying 3-D brain images, is described. This tool was programmed to solve basic problems in 3-D data visualization. It is written in Java so it is extensible, is platform independent, and can display images within web pages. iiV displays 3-D images as 2-dimensional (2-D) slices with each slice being an independent object with independent features such as location, zoom, colors, labels, etc. Feature manipulation becomes easier by having a full set of editing capabilities including the following: undo or redo changes; drag, copy, delete and paste objects; and save objects with their features to a file for future editing. It can read multiple standard positron emission tomography (PET) and magnetic resonance imaging (MRI) file formats like ECAT, ECAT7, ANALYZE, NIfTI-1 and DICOM. We present sample applications to illustrate some of the features and capabilities. Conclusion iiV is an image display tool with many useful features. It is highly extensible, platform independent, and web-compatible. This report summarizes its features and applications, while illustrating iiV's usefulness to the biomedical imaging community. PMID:18510765

  9. IDEA Oral Language Proficiency Test (IPT II).

    ERIC Educational Resources Information Center

    Stansfield, Charles W.

    The IDEA Oral Language Proficiency Test (IPT II), an individually-administered measure of speaking and listening proficiency in English as a Second Language designed for secondary school students, is described and discussed. The test consists of 91 items and requires 5-25 minutes to administer. Raw scores are converted to one of seven proficiency…

  10. Neurofibromatosis types I and II: radiological appearance.

    PubMed

    Romanowski, C A; Cavallin, L I

    1998-02-01

    The neurocutaneous disorders frequently involve the central nervous system. This, the first in a pair of articles which describe and illustrate the radiological appearances of the central nervous system manifestations of the most common neurocutaneous disorders, looks at neurofibromatosis types I and II.

  11. Diffraction with CDF II at the Tevatron

    SciTech Connect

    Goulianos, Konstantin

    2009-03-23

    Results on diffraction from the Fermilab Tevatron collider obtained by the CDF II Collaboration using data from pp-bar collisions at {radical}(s) = 1.96 TeV are reviewed and compared with theoretical expectations. Implications for predictions of exclusive Higgs boson production rates at the Large Hadron Collider are discussed.

  12. National Ignition Facility Title II Design Plan

    SciTech Connect

    Kumpan, S

    1997-03-01

    This National Ignition Facility (NIF) Title II Design Plan defines the work to be performed by the NIF Project Team between November 1996, when the U.S. Department of Energy (DOE) reviewed Title I design and authorized the initiation of Title H design and specific long-lead procurements, and September 1998, when Title 11 design will be completed.

  13. Spectroscopy of gluonic states at LAMPF II

    SciTech Connect

    Chanowitz, M.S.

    1983-08-01

    The properties of QCD which imply the existence of gluonic states are reviewed. The problem of discovering the spectrum of gluonic states is discussed in general and illustrated with examples from current data. Higher statistics fixed target experiments, such as could be performed at LAMPF II, are essential for further progress.

  14. Biceps Tenodesis for Type II SLAP Tears.

    PubMed

    Tayrose, Gregory A; Karas, Spero G; Bosco, Joseph

    2015-06-01

    Tears of the superior glenoid labrum are a common cause of shoulder pain and disability, especially in overhead athletes such as pitchers, swimmers, and volleyball players. Type II SLAP lesions have been the most clinically important superior labral pathology, and the management of this lesion has been a very controversial topic. Currently, there are no high level studies in the literature to guide treatment. While the few level 3 and level 4 evidence studies that are available following arthroscopic repair of type II SLAP lesions all report reasonable overall patient satisfaction, persistent postoperative pain is common and associated with a low return to pre-injury level of sports participation. There has been a recent school of thought that biceps tenodesis, which maintains the length-tension relationship of the long head of biceps, should be the procedure of choice for patients with isolated type II SLAP lesions. The current paper reviews the role biceps tenodesis plays in the management of type II SLAP tears.

  15. Topaz-II reactor control unit development

    SciTech Connect

    Wyant, F.J.; Jensen, D.; Logothetis, J.

    1994-12-31

    The development for a new digital reactor control unit for the Topaz-II reactor is described. The unit is expected to provide the means for automated control during a possible Topaz flight experiment. The breadboard design and development is discussed.

  16. Cu(II) promotes amyloid pore formation

    SciTech Connect

    Zhang, Hangyu; Rochet, Jean-Christophe; Stanciu, Lia A.

    2015-08-14

    The aggregation of α-synuclein is associated with dopamine neuron death in Parkinson's disease. There is controversy in the field over the question of which species of the aggregates, fibrils or protofibrils, are toxic. Moreover, compelling evidence suggested the exposure to heavy metals to be a risk of PD. Nevertheless, the mechanism of metal ions in promoting PD remains unclear. In this research, we investigated the structural basis of Cu(II) induced aggregation of α-synuclein. Using transmission electron microscopy experiments, Cu(II) was found to promote in vitro aggregation of α-synuclein by facilitating annular protofibril formation rather than fibril formation. Furthermore, neuroprotective baicalein disaggregated annular protofibrils accompanied by considerable decrease of β-sheet content. These results strongly support the hypothesis that annular protofibrils are the toxic species, rather than fibrils, thereby inspiring us to search novel therapeutic strategies for the suppression of the toxic annular protofibril formation. - Highlights: • Cu(II) promoted the annular protofibril formation of α-synuclein in vitro. • Cu(II) postponed the in vitro fibrillization of α-synuclein. • Neuroprotective baicalein disaggregated annular protofibrils.

  17. Project Final Report: HPC-Colony II

    SciTech Connect

    Jones, Terry R; Kale, Laxmikant V; Moreira, Jose

    2013-11-01

    This report recounts the HPC Colony II Project which was a computer science effort funded by DOE's Advanced Scientific Computing Research office. The project included researchers from ORNL, IBM, and the University of Illinois at Urbana-Champaign. The topic of the effort was adaptive system software for extreme scale parallel machines. A description of findings is included.

  18. [A case of type II achondrogenesis].

    PubMed

    Micheli, E; Perrone, C; Quarta Colosso, L; Vetrugno, M; Zecca, G; Indirli, G C; Greco, F; Elia, G; Ciancio, S

    1996-01-01

    We describe a rare case of type II achondrogenesis (gestational age = thirty-two weeks) dead forty-five minutes after birth. This congenital skeletal dysplasia is classified among the lethal osteochondrodysplasias. Clinical features were enough for diagnosis and autopsy added nothing to our clinical knowledges. PMID:8685014

  19. Occupational Information 1990/91. Volume II.

    ERIC Educational Resources Information Center

    Nebraska Univ., Lincoln. Nebraska Career Information System.

    The Nebraska Occupational Information books (volumes I and II) contain information about 386 different occupations in the state and answer questions about specific occupations in detail. The descriptions are arranged according to a U.S. Department of Labor classification system, with occupational titles clustered in general groups of selected…

  20. Heavy flavor physics at CDF II

    SciTech Connect

    A. Cerri

    2001-07-12

    Tevatron experiments will soon begin Run II data taking with an aggressive B physics program. The B physics reach of the CDF and D0 experiments already seems competitive and complementary to that of B factories. We report on the future plans for B physics and CP violation measurements at the Tevatron.

  1. An ADC Interface for the Apple II.

    ERIC Educational Resources Information Center

    Leiker, P. Steven

    1990-01-01

    Described is the construction of a simple analog-to-digital convertor circuit to interface an Apple II+ microcomputer to a light sensor used in conjunction with a holographic gear inspector. A list of parts, circuit diagram, and a simple BASIC program for the convertor are provided. (CW)

  2. The RDP-II (Ribosomal Database Project).

    PubMed

    Maidak, B L; Cole, J R; Lilburn, T G; Parker, C T; Saxman, P R; Farris, R J; Garrity, G M; Olsen, G J; Schmidt, T M; Tiedje, J M

    2001-01-01

    The Ribosomal Database Project (RDP-II), previously described by Maidak et al. [Nucleic Acids Res. (2000), 28, 173-174], continued during the past year to add new rRNA sequences to the aligned data and to improve the analysis commands. Release 8.0 (June 1, 2000) consisted of 16 277 aligned prokaryotic small subunit (SSU) rRNA sequences while the number of eukaryotic and mitochondrial SSU rRNA sequences in aligned form remained at 2055 and 1503, respectively. The number of prokaryotic SSU rRNA sequences more than doubled from the previous release 14 months earlier, and approximately 75% are longer than 899 bp. An RDP-II mirror site in Japan is now available (http://wdcm.nig.ac.jp/RDP/html/index.h tml). RDP-II provides aligned and annotated rRNA sequences, derived phylogenetic trees and taxonomic hierarchies, and analysis services through its WWW server (http://rdp.cme.msu.edu/). Analysis services include rRNA probe checking, approximate phylogenetic placement of user sequences, screening user sequences for possible chimeric rRNA sequences, automated alignment, production of similarity matrices and services to plan and analyze terminal restriction fragment polymorphism experiments. The RDP-II email address for questions and comments has been changed from curator@cme.msu.edu to rdpstaff@msu.edu.

  3. A Camp Director Remembers World War II.

    ERIC Educational Resources Information Center

    Cohen, Helen Herz

    2003-01-01

    A girl's camp in Maine during World War II had to deal with food rationing and black-market food dealers. Campers picked beans to raise money for refugees, sewed clothes for refugees, and spotted for enemy planes from Mt. Pleasant. An attempt to use a horse-drawn cart for transportation failed, and good help was hard to find. (TD)

  4. Symbol Character Generator Developed for Decwriter II

    SciTech Connect

    Sand, R.J.

    2001-03-15

    The versatile dot matrix printer of the DECwriter II was modified to enable printing of symbol characters., e.g., Greek letters and other symbol for mathematical expressions and units of measurement. This development involved the replacement of the read-only memory (ROM) units with erasable-programmable read-only memory (EPROM) units.

  5. The Amityville Experience During World War II.

    ERIC Educational Resources Information Center

    Journal of Historical Inquiry, 1985

    1985-01-01

    An historical journal compiled by advanced placement American history high school students contains 10 articles about the experiences of residents of Amityville, New York, during World War II. Students used secondary sources, first-hand newspaper accounts, oral interviews, and primary source documents to recreate Amityville as it was during those…

  6. FR II radio galaxies at low frequencies

    NASA Astrophysics Data System (ADS)

    Harwood, Jeremy

    2016-08-01

    Due to their steep spectra, low-frequency observations of FR II radio galaxies potentially provide key insights in to the morphology, energetics and underlying physics of these powerful radio sources. However, limitations imposed by the previous generation of radio interferometers at metre wavelengths have meant that this region of parameter space remains largely unexplored.In this talk, we present our latest results using LOFAR and the JVLA at frequencies between 50 and 460 MHz which, along with complementary archival radio and X-ray data, now allows us to undertake well resolved, detailed studies of nearby FR II radio galaxies at low frequencies. We discuss how our improved knowledge of the low-energy electron distribution, magnetic field strength and total energy content of the lobes impacts upon our understanding of the dynamics and energetics of nearby FR II radio galaxies and, for the first time, present the spectral structure of these sources on small spatial scales at low frequencies. We conclude by discussing how these findings change our current understanding of the underlying physics of FR II radio galaxies and, ultimately, their impact on the environment and galaxy evolution as a whole.

  7. Colleges and Universities in World War II.

    ERIC Educational Resources Information Center

    Cardozier, V. R.

    This book examines the impact of World War II on college campuses and how the large military influence during that period affected such areas as the emergence of new fields of study, the role of the professor, and the social utility of higher education. Specific chapters examine Army, Navy, and Army Air Forces College Training Programs; how…

  8. Structural, optical, and magnetic properties of Na{sub 8}Eu{sub 2}(Si{sub 2}S{sub 6}){sub 2} and Na{sub 8}Eu{sub 2}(Ge{sub 2}S{sub 6}){sub 2}: Europium(II) quaternary chalcogenides that contain an ethane-like (Si{sub 2}S{sub 6}){sup 6−} or (Ge{sub 2}S{sub 6}){sup 6−} moiety

    SciTech Connect

    Choudhury, Amitava; Ghosh, Kartik; Grandjean, Fernande; Long, Gary J.; Dorhout, Peter K.

    2015-03-15

    Two isostructural europium(II) quaternary chalcogenides, Na{sub 8}Eu{sub 2}(Si{sub 2}S{sub 6}){sub 2}, 1, and Na{sub 8}Eu{sub 2}(Ge{sub 2}S{sub 6}){sub 2}, 2, containing an ethane-like (Si{sub 2}S{sub 6}){sup 6−} or (Ge{sub 2}S{sub 6}){sup 6−} moiety have been synthesized by employing the polychalcogenide molten flux method. Single-crystal X-ray diffraction reveals that both compounds crystallize in the C2/m space group, and their structures contain layers of ([Na{sub 2}Eu{sub 2}(Si{sub 2}S{sub 6}){sub 2}]{sup 6−}){sub ∞} or ([Na{sub 2}Eu{sub 2}(Ge{sub 2}S{sub 6}){sub 2}]{sup 6−}){sub ∞} anions held together by six interlayer sodium cations to yield (Na{sub 6}[Na{sub 2}Eu{sub 2}(Si{sub 2}S{sub 6}){sub 2}]){sub ∞} and (Na{sub 6}[Na{sub 2}Eu{sub 2}(Ge{sub 2}S{sub 6}){sub 2}]){sub ∞}. Compound 2 is a semiconductor with an optical band gap of 2.15(2) eV. The temperature dependence of the magnetic susceptibility indicates that compounds 1 and 2 are paramagnetic with μ{sub eff}=7.794(1) μ{sub B} per Eu and g=1.964(1) for 1 and μ{sub eff}=8.016(1) μ{sub B} per Eu and g=2.020(1) for 2, moments that are in good agreement with the europium(II) spin-only moment of 7.94 μ{sub B}. The europium-151 Mössbauer isomer shift of 2 confirms the presence of europium(II) cations with an electronic configuration between [Xe]4f{sup 6.81} and 4f{sup 7}6s{sup 0.32}. - Graphical abstract: TOC figure caption: structure of Na{sub 8}Eu{sub 2}(Si{sub 2}S{sub 6}){sub 2} viewed along the a-axis showing the filling of A–B and B–A types of anion layers with two different types of cations. - Highlights: • Synthesis of quaternary europium chalcogenides containing ethane-like dimer. • Structural characterization employing single-crystal X-ray diffraction. • Mössbauer spectroscopy and magnetic measurements confirm presence of Eu(II)

  9. VELOCITY-RESOLVED [C ii] EMISSION AND [C ii]/FIR MAPPING ALONG ORION WITH HERSCHEL *,**

    PubMed Central

    Goicoechea, Javier R.; Teyssier, D.; Etxaluze, M.; Goldsmith, P.F.; Ossenkopf, V.; Gerin, M.; Bergin, E.A.; Black, J.H.; Cernicharo, J.; Cuadrado, S.; Encrenaz, P.; Falgarone, E.; Fuente, A.; Hacar, A.; Lis, D.C.; Marcelino, N.; Melnick, G.J.; Müller, H.S.P.; Persson, C.; Pety, J.; Röllig, M.; Schilke, P.; Simon, R.; Snell, R.L.; Stutzki, J.

    2015-01-01

    We present the first ~7.5′×11.5′ velocity-resolved (~0.2 km s−1) map of the [C ii] 158 μm line toward the Orion molecular cloud 1 (OMC 1) taken with the Herschel/HIFI instrument. In combination with far-infrared (FIR) photometric images and velocity-resolved maps of the H41α hydrogen recombination and CO J=2-1 lines, this data set provides an unprecedented view of the intricate small-scale kinematics of the ionized/PDR/molecular gas interfaces and of the radiative feedback from massive stars. The main contribution to the [C ii] luminosity (~85 %) is from the extended, FUV-illuminated face of the cloud (G0>500, nH>5×103 cm−3) and from dense PDRs (G≳104, nH≳105 cm−3) at the interface between OMC 1 and the H ii region surrounding the Trapezium cluster. Around ~15 % of the [C ii] emission arises from a different gas component without CO counterpart. The [C ii] excitation, PDR gas turbulence, line opacity (from [13C ii]) and role of the geometry of the illuminating stars with respect to the cloud are investigated. We construct maps of the L[C ii]/LFIR and LFIR/MGas ratios and show that L[C ii]/LFIR decreases from the extended cloud component (~10−2–10−3) to the more opaque star-forming cores (~10−3–10−4). The lowest values are reminiscent of the “[C ii] deficit” seen in local ultra-luminous IR galaxies hosting vigorous star formation. Spatial correlation analysis shows that the decreasing L[C ii]/LFIR ratio correlates better with the column density of dust through the molecular cloud than with LFIR/MGas. We conclude that the [C ii] emitting column relative to the total dust column along each line of sight is responsible for the observed L[C ii]/LFIR variations through the cloud. PMID:26568638

  10. Rapid and sensitive colorimetric determination of cobalt(II).

    PubMed

    Eldawy, M A; Tawfik, A S; Elshabouri, S R

    1976-05-01

    A highly selective and sensitive spectrophotometric determination of cobalt (II) was developed. 7-Nitroso-8-hydroxyquinoline-5-sulfonic acid sodium salt was used as the chromogenic reagent for color development. Although other metals form colored chelates with the ligand, it was possible to develop a selective method using McIlvaine's pH 8 citric acid-phosphate buffer. Under these conditions, iron(II), iron (III), copper (II), zinc (II), and manganese (II), minerals likely to be compounded with cobalt (II) in geriatric formulations, do not interfere with the precision of the method or the color development. Calcium (II) and magnesium (II) do not form colored chelates with the used ligand. Hormones, vitamins, and additives likely to be present along with the cobalt ion in pharmaceutical formulations do not interfere. The sensitivity is 0.37 mug of cobalt (II)/ml of sample solution.

  11. Influence of different mineral and Organic pesticide treatments on Cd(II), Cu(II), Pb(II), and Zn(II) contents determined by derivative potentiometric stripping analysis in Italian white and red wines.

    PubMed

    Salvo, Francesco; La Pera, Lara; Di Bella, Giuseppa; Nicotina, Mariano; Dugo, Giacomo

    2003-02-12

    This paper deals with the use of derivative potentiometric stripping analysis (dPSA) as a rapid and precise method to determine Cd(II), Cu(II), Pb(II), and Zn(II) levels in red and white wine samples from Sicily, Campania, and Tuscany and to investigate the possible connection between the content of these metals and the pesticide treatments used in vine-growing to control plant diseases and pests. dPSA allowed direct quantitation of heavy metals in acidified wines without any sample pretreatment. Mean recoveries of Cd(II), Cu(II), Pb(II), and Zn(II) ranged from 95.5 to 99.2% for white wine samples and from 96.1 to 100.0% for red wine samples. The obtained results showed that Cd(II) was not found in any sample and that Cu(II), Pb(II), and Zn(II) levels were always lower than the toxicity limits in both fungicide- and water-treated wines. Nevertheless, the contents of metals were increased in samples from organic and inorganic pesticides treatment with respect to the water-treated samples. In particular, quinoxyfen, dinocap-penconazole, and dinocap applications considerably increased Cu(II) and Zn(II) contents in white and red wines. The levels of lead were significantly raised by azoxystrobin and sulfur treatments.

  12. Synthesis and characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate Schiff base derived from vanillin and DL-α-aminobutyric acid

    NASA Astrophysics Data System (ADS)

    Nair, M. Sivasankaran; Joseyphus, R. Selwin

    2008-09-01

    Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base derived from vanillin and DL-α-aminobutyric acid were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, magnetic measurements, powder XRD and biological activity. The analytical data show the composition of the metal complex to be [ML(H 2O)], where L is the Schiff base ligand. The conductance data indicate that all the complexes are non-electrolytes. IR results demonstrate the tridentate binding of the Schiff base ligand involving azomethine nitrogen, phenolic oxygen and carboxylato oxygen atoms. The IR data also indicate the coordination of a water molecule with the metal ion in the complex. The electronic spectral measurements show that Co(II) and Ni(II) complexes have tetrahedral geometry, while Cu(II) complex has square planar geometry. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, whereas Ni(II) and Zn(II) complexes are crystalline in nature. Magnetic measurements show that Co(II), Ni(II) and Cu(II) complexes have paramagnetic behaviour. Antibacterial results indicated that the metal complexes are more active than the ligand.

  13. Linear trinuclear cobalt(II) single molecule magnet.

    PubMed

    Zhang, Yuan-Zhu; Brown, Andrew J; Meng, Yin-Shan; Sun, Hao-Ling; Gao, Song

    2015-02-14

    The introduction of NaBPh(4) into a methanolic solution of CoCl(2)·(6)H(2)O and 2-[(pyridine-2-ylimine)-methyl]phenol (Hpymp) afforded {[Co(II)(3)(pymp)(4)(MeOH)(2)][BPh(4)](2)}·(2)MeOH (1) with a centro-symmetrically linear trinuclear structure. Magnetic analysis of 1 exhibited significant intracluster ferromagnetic exchange (2.4 cm(-1)) and slow relaxation of magnetization in both zero and non-zero static fields below 5 K, giving the first [Co(II)(3)] single molecule magnet with an effective energy barrier of 17.2(3) cm(-1) under a 500 Oe dc field.

  14. Zn(II) ions substantially perturb Cu(II) ion coordination in amyloid-β at physiological pH.

    PubMed

    Silva, K Ishara; Saxena, Sunil

    2013-08-15

    The interaction of Cu(II) and Zn(II) ions with amyloid-β (Aβ) plays an important role in the etiology of Alzheimer's disease. We describe the use of electron spin resonance (ESR) to measure metal-binding competition between Cu(II) and Zn(II) in amyloid-β at physiological pH. Continuous wave ESR measurements show that the affinity of Cu(II) toward Aβ(1-16) is significantly higher than that of Zn(II) at physiological pH. Importantly, of the two known Cu(II) coordination modes in Aβ, component I and component II, Zn(II) displaces Cu(II) only from component I. Our results indicate that at excess amounts of Zn(II) component II becomes the most dominant coordination mode. This observation is important as Aβ aggregates in the brain contain a high Zn(II) ion concentration. In order to determine details of the metal ion competition, electron spin echo envelope modulation experiments were carried out on Aβ variants that were systematically (15)N labeled. In the presence of Zn(II), most peptides use His 14 as an equatorial ligand to bind Cu(II) ions. Interestingly, Zn(II) ions completely substitute Cu(II) ions that are simultaneously coordinated to His 6 and His 13. Furthermore, in the presence of Zn(II), the proportion of Cu(II) ions that are simultaneously coordinated to His 13 and His 14 is increased. On the basis of our results we suggest that His 13 plays a critical role in modulating the morphology of Aβ aggregates.

  15. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron.

    PubMed

    Nguyen, Mien T X; Han, Jiyang; Ralph, Donna L; Veiras, Luciana C; McDonough, Alicia A

    2015-09-01

    In Sprague Dawley rats, 2-week angiotensin II (AngII) infusion increases Na(+) transporter abundance and activation from cortical thick ascending loop of Henle (TALH) to medullary collecting duct (CD) and raises blood pressure associated with a pressure natriuresis, accompanied by depressed Na(+) transporter abundance and activation from proximal tubule (PT) through medullary TALH. This study tests the hypothesis that early during AngII infusion, before blood pressure raises, Na(+) transporters' abundance and activation increase all along the nephron. Male Sprague Dawley rats were infused via osmotic minipumps with a subpressor dose of AngII (200 ng/kg/min) or vehicle for 3 days. Overnight urine was collected in metabolic cages and sodium transporters' abundance and phosphorylation were determined by immunoblotting homogenates of renal cortex and medulla. There were no significant differences in body weight gain, overnight urine volume, urinary Na(+) and K(+) excretion, or rate of excretion of a saline challenge between AngII and vehicle infused rats. The 3-day nonpressor AngII infusion significantly increased the abundance of PT Na(+)/H(+) exchanger 3 (NHE3), cortical TALH Na-K-2Cl cotransporter 2 (NKCC2), distal convoluted tubule (DCT) Na-Cl cotransporter (NCC), and cortical CD ENaC subunits. Additionally, phosphorylation of cortical NKCC2, NCC, and STE20/SPS1-related proline-alanine-rich kinase (SPAK) were increased; medullary NKCC2 and SPAK were not altered. In conclusion, 3-day AngII infusion provokes PT NHE3 accumulation as well as NKCC2, NCC, and SPAK accumulation and activation in a prehypertensive phase before evidence for intrarenal angiotensinogen accumulation. PMID:26347505

  16. Synthesis, spectral characterization and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with 2-amino benzoic acid- and 2-hydroxy benzoic acid thiophen-2-ylmethylene hydrazide

    NASA Astrophysics Data System (ADS)

    Singh, Vinod P.; Singh, Pooja

    2013-03-01

    A series of metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with 2-amino benzoic acid thiophen-2-ylmethylene hydrazide (Habth) and 2-hydroxy benzoic acid thiophen-2-ylmethylene hydrazide (Hhbth) have been synthesized. The complexes were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, electronic, IR, NMR, ESR spectra and thermal studies (TGA and DTA). Molecular structure of the Habth ligand was determined by single crystal X-ray diffraction technique. Habth acts as a monobasic bidentate ligand in all its complexes bonding through a deprotonated Csbnd O- and lbond2 Cdbnd Nsbnd groups whereas, Hhbth acts as a monobasic bidentate in its Co(II) and Ni(II) complexes, bonding through a deprotonated Csbnd O- and lbond2 Cdbnd Nsbnd groups and as monobasic tridentate in Cu(II) and Zn(II) complexes bonding through lbond2 Cdbnd O, lbond2 Cdbnd Nsbnd and deprotonated (Csbnd O)- groups with the metal ion. Electronic spectra suggest a square planar geometry for Co(II), Ni(II) and Cu(II) complexes of Habth and Co(II) and Ni(II) complexes of Hhbth. However, the Cu(II) and Zn(II) complexes of Hhbth have octahedral geometry. The ESR spectra of Cu(II) complex of Hhbth in the solid state and in DMSO frozen solution show axial signals and suggest the presence of unpaired electron in d orbital of Cu(II). The Cu(II) complex of Habth in solid state shows isotropic signal, whereas, axial signal in DMSO frozen solution in the range of tetragonally distorted octahedral geometry due to interactions of DMSO molecules at axial positions. Thermal studies of some of the metal complexes show a multi-step decomposition pattern of bonded ligands in the complex.

  17. Angiotensin II during Experimentally Simulated Central Hypovolemia

    PubMed Central

    Jensen, Theo Walther; Olsen, Niels Vidiendal

    2016-01-01

    Central hypovolemia, defined as diminished blood volume in the heart and pulmonary vascular bed, is still an unresolved problem from a therapeutic point of view. The development of pharmaceutical agents targeted at specific angiotensin II receptors, such as the non-peptidergic AT2-receptor agonist compound 21, is yielding many opportunities to uncover more knowledge about angiotensin II receptor profiles and possible therapeutic use. Cardiovascular, anti-inflammatory, and neuroprotective therapeutic use of compound 21 have been suggested. However, there has not yet been a focus on the use of these agents in a hypovolemic setting. We argue that the latest debates on the effect of angiotensin II during hypovolemia might guide for future studies, investigating the effect of such agents during experimentally simulated central hypovolemia. The purpose of this review is to examine the role of angiotensin II during episodes of central hypovolemia. To examine this, we reviewed results from studies with three experimental models of simulated hypovolemia: head up tilt table test, lower body negative pressure, and hemorrhage of animals. A systemic literature search was made with the use of PubMed/MEDLINE for studies that measured variables of the renin–angiotensin system or its effect during simulated hypovolemia. Twelve articles, using one of the three models, were included and showed a possible organ-protective effect and an effect on the sympathetic system of angiotensin II during hypovolemia. The results support the possible organ-protective vasodilatory role for the AT2-receptor during hypovolemia on both the kidney and the splanchnic tissue. PMID:26973842

  18. Angiotensin II: multitasking in the brain.

    PubMed

    Saavedra, Juan M; Benicky, Julius; Zhou, Jin

    2006-03-01

    In addition to controlling systemic blood pressure, angiotensin II (Ang II) has several roles in the brain, including the regulation of cerebrovascular flow and the reaction to stress. In order to clarify the central effects of Ang II and its type 1 (AT1) receptors, we reviewed the literature reporting recent research on the effects of pretreatment with the AT1-receptor blocker, candesartan, on experimental ischemia, cerebrovascular remodeling, and inflammation in spontaneously hypertensive rats (SHRs), and the responses to stress induced by isolation and by cold-restraint. Angiotensin II regulates the brain circulation through stimulation of AT1-receptors located in the cerebrovascular endothelium and central pathways. SHRs express greater numbers of endothelial AT1-receptors and a central sympathetic overdrive, resulting in pathological cerebrovascular growth, inflammation, decreased cerebrovascular compliance, and enhanced vulnerability to brain ischemia. Sustained central AT1-receptor antagonism reverses these effects. Sustained reduction of AT1-receptor stimulation before stress prevents the hormonal and sympathoadrenal stress responses during isolation and prevents the gastric ulceration stress response to cold-restraint, indicating that increased AT1-receptor stimulation is essential to enhance the central sympathetic response and the formation and release of corticotropin-releasing factor (CRF) and arginine vasopressin that occur during stress. AT1-receptor blocking agents reverse the cortical alterations in CRF1 and benzodiazepine receptors characteristic of isolation stress, effects probably related to their anti-anxiety effect in rodents. Sustained reduction of Ang II tone by AT1-receptor antagonism could be considered as a preventive and therapeutic approach for brain ischemia and stress-related and mood disorders. Additional preclinical studies and controlled clinical trials are necessary to confirm the efficacy of this novel therapeutic approach.

  19. Synthesis and characterization of VO(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based azo-linked Schiff base ligand

    NASA Astrophysics Data System (ADS)

    Anitha, C.; Sheela, C. D.; Tharmaraj, P.; Johnson Raja, S.

    2012-12-01

    Azo-Schiff-base complexes of VO(II), Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized and characterized by elemental analysis, IR, UV-Vis, 1H NMR, mass spectra, molar conductance, magnetic susceptibility measurement, electron spin resonance (EPR), CV, fluorescence, NLO and SEM. The conductance data indicate the nonelectrolytic nature of the complexes, except VO(II) complex which is electrolytic in nature. On the basis of electronic spectra and magnetic susceptibility octahedral geometry has been proposed for the complexes. The EPR spectra of copper and oxovanadium complexes in DMSO at 300 and 77 K were recorded and its salient features are reported. The redox behavior of the copper(II) complex was studied using cyclic voltammetry. The in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella enterica typhi, Bacillus subtilis and Candida strains was studied and compared with that of free ligand by well-diffusion technique. The azo Schiff base exhibited fluorescence properties originating from intraligand (π-π∗) transitions and metal-mediated enhancement is observed on complexation and so the synthesized complexes can serve as potential photoactive materials as indicated from their characteristic fluorescence properties. On the basis of the optimized structures, the second-order nonlinear optical properties (NLO) are calculated by using second-harmonic generation (SHG) and also the surface morphology of the complexes was studied by SEM.

  20. Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II).

    PubMed

    Yadav, Arun A; Patel, Daywin; Wu, Xing; Hasinoff, Brian B

    2013-09-01

    The bis(thiohydrazide) amide elesclomol has extremely potent antiproliferative activity and is currently in clinical trials as an anticancer agent. Elesclomol strongly binds copper and may be exerting its cell growth inhibitory effects by generating copper-mediated oxidative stress. Nickel(II) and platinum(II) complexes of elesclomol were synthesized and characterized in order to investigate if these biologically redox inactive metal complexes could also inhibit cell growth. The nickel(II)-elesclomol and platinum(II) elesclomol complexes were 34- and 1040-fold less potent than the copper(II)-elesclomol complex towards human leukemia K562 cells. These results support the conclusion that a redox active metal is required for elesclomol to exert its cell growth inhibitory activity. Copper(II)-elesclomol was also shown to efficiently oxidize ascorbic acid at physiological ascorbic acid concentrations. Reoxidation of the copper(I) thus produced would lead to production of damaging reactive oxygen species. An X-ray crystallographic structure determination of copper(II)-elesclomol showed that it formed a 1:1 neutral complex with a distorted square planar structure. The kinetics and equilibria of the competition reaction of the strong copper(II) chelator TRIEN with copper(II)-elesclomol were studied spectrophotometrically under physiological conditions. These results showed elesclomol bound copper(II) with a conditional stability constant 24-fold larger than TRIEN. A log stability constant of 24.2 was thus indirectly determined for the copper(II)-elesclomol complex.

  1. Synthesis, Structure, and Reactivity of Co(II) and Ni(II) PCP Pincer Borohydride Complexes

    PubMed Central

    2015-01-01

    The 15e square-planar complexes [Co(PCPMe-iPr)Cl] (2a) and [Co(PCP-tBu)Cl] (2b), respectively, react readily with NaBH4 to afford complexes [Co(PCPMe-iPr)(η2-BH4)] (4a) and [Co(PCP-tBu)(η2-BH4)] (4b) in high yields, as confirmed by IR spectroscopy, X-ray crystallography, and elemental analysis. The borohydride ligand is symmetrically bound to the cobalt center in η2-fashion. These compounds are paramagnetic with effective magnetic moments of 2.0(1) and 2.1(1) μB consistent with a d7 low-spin system corresponding to one unpaired electron. None of these complexes reacted with CO2 to give formate complexes. For structural and reactivity comparisons, we prepared the analogous Ni(II) borohydride complex [Ni(PCPMe-iPr)(η2-BH4)] (5) via two different synthetic routes. One utilizes [Ni(PCPMe-iPr)Cl] (3) and NaBH4, the second one makes use of the hydride complex [Ni(PCPMe-iPr)H] (6) and BH3·THF. In both cases, 5 is obtained in high yields. In contrast to 4a and 4b, the borohydride ligand is asymmetrically bound to the nickel center but still in an η2-mode. [Ni(PCPMe-iPr)(η2-BH4)] (5) loses readily BH3 at elevated temperatures in the presence of NEt3 to form 6. Complexes 5 and 6 are both diamagnetic and were characterized by a combination of 1H, 13C{1H}, and 31P{1H} NMR, IR spectroscopy, and elemental analysis. Additionally, the structure of these compounds was established by X-ray crystallography. Complexes 5 and 6 react with CO2 to give the formate complex [Ni(PCPMe-iPr)(OC(C=O)H] (7). The extrusion of BH3 from [Co(PCPMe-iPr)(η2-BH4)] (4a) and [Ni(PCPMe-iPr)(η2-BH4)] (5) with the aid of NH3 to yield the respective hydride complexes [Co(PCPMe-iPr)H] and [Ni(PCPMe-iPr)H] (6) and BH3NH3 was investigated by DFT calculations showing that formation of the Ni hydride is thermodynamically favorable, whereas the formation of the Co(II) hydride, in agreement with the experiment, is unfavorable. The electronic structures and the bonding of the borohydride ligand in [Co

  2. Thiol-functionalized polysilsesquioxane as efficient adsorbent for adsorption of Hg(II) and Mn(II) from aqueous solution

    SciTech Connect

    Niu, Yuzhong Qu, Rongjun; Liu, Xiguang; Mu, Lei; Bu, Baihui; Sun, Yuting; Chen, Hou; Meng, Yangfeng; Meng, Lina; Cheng, Lin

    2014-04-01

    Highlights: • PMPSQ was promising adsorbent for the removal of Hg(II) and Mn(II). • The adsorption kinetics followed the pseudo-second-order model. • The adsorption isotherms can be described by the monolayer Langmuir model. • The adsorption was controlled by film diffusion and chemical ion-exchange mechanism. - Abstract: Thiol-functionalized polysilsesquioxane was synthesized and used for the adsorption of Hg(II) and Mn(II) from aqueous solution. Results showed that the optimal pH was about 6 and 5 for Hg(II) and Mn(II), respectively. Adsorption kinetics showed that the adsorption equilibriums were established within 100 min and followed pseudo-second-order model. Adsorption isotherms revealed that the adsorption capacities increased with the increasing of temperature. The adsorption was found to be well described by the monolayer Langmuir isotherm model and took place by chemical ion-exchange mechanism. The thermodynamic properties indicated the adsorption processes were spontaneous and endothermic nature. Selectively adsorption showed that PMPSQ can selectively adsorb Hg(II) from binary ion systems in the presence of the coexistent ions Mn(II), Cu(II), Pb(II), Co(II), and Ni(II). Based on the results, it is concluded that PMPSQ had comparable high adsorption efficiency and could be potentially used for the removal of Hg(II) and Mn(II) from aqueous solution.

  3. Spectral studies on Co(II), Ni(II) and Cu(II) complexes with thiosemicarbazone (L 1) and semicarbazone (L 2) derived from 2-acetyl furan

    NASA Astrophysics Data System (ADS)

    Chandra, Sulekh; Kumar, Anil

    2007-04-01

    Co(II), Ni(II) and Cu(II) complexes are synthesized with thiosemicarbazone (L 1) and semicarbazone (L 2) derived from 2-acetyl furan. These complexes are characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, mass, IR, electronic and EPR spectral studies. The molar conductance measurements of the complexes in DMSO correspond to non-electrolytic nature except Ni(L) 2(NO 3) 2, which is 1:2 electrolyte. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry may be assigned for Co(II) and Ni(II) complexes except nitrato complexes of Ni(II) which is of tetrahedral geometry, whereas tetragonal geometry for Cu(II) complexes.

  4. Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension.

    PubMed

    Veiras, Luciana C; Han, Jiyang; Ralph, Donna L; McDonough, Alicia A

    2016-10-01

    Angiotensin II (AngII) hypertension increases distal tubule Na-Cl cotransporter (NCC) abundance and phosphorylation (NCCp), as well as epithelial Na(+) channel abundance and activating cleavage. Acutely raising plasma [K(+)] by infusion or ingestion provokes a rapid decrease in NCCp that drives a compensatory kaliuresis. The first aim tested whether acutely raising plasma [K(+)] with a single 3-hour 2% potassium meal would lower NCCp in Sprague-Dawley rats after 14 days of AngII (400 ng/kg per minute). The potassium-rich meal neither decreased NCCp nor increased K(+) excretion. AngII-infused rats exhibited lower plasma [K(+)] versus controls (3.6±0.2 versus 4.5±0.1 mmol/L; P<0.05), suggesting that AngII-mediated epithelial Na(+) channel activation provokes K(+) depletion. The second aim tested whether doubling dietary potassium intake from 1% (A1K) to 2% (A2K) would prevent K(+) depletion during AngII infusion and, thus, prevent NCC accumulation. A2K-fed rats exhibited normal plasma [K(+)] and 2-fold higher K(+) excretion and plasma [aldosterone] versus A1K. In A1K rats, NCC, NCCpS71, and NCCpT53 abundance increased 1.5- to 3-fold versus controls (P<0.05). The rise in NCC and NCCp abundance was prevented in the A2K rats, yet blood pressure did not significantly decrease. Epithelial Na(+) channel subunit abundance and cleavage increased 1.5- to 3-fold in both A1K and A2K; ROMK (renal outer medulla K(+) channel abundance) abundance was unaffected by AngII or dietary K(+) In summary, the accumulation and phosphorylation of NCC seen during chronic AngII infusion hypertension is likely secondary to potassium deficiency driven by epithelial Na(+) channel stimulation.

  5. Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension.

    PubMed

    Veiras, Luciana C; Han, Jiyang; Ralph, Donna L; McDonough, Alicia A

    2016-10-01

    Angiotensin II (AngII) hypertension increases distal tubule Na-Cl cotransporter (NCC) abundance and phosphorylation (NCCp), as well as epithelial Na(+) channel abundance and activating cleavage. Acutely raising plasma [K(+)] by infusion or ingestion provokes a rapid decrease in NCCp that drives a compensatory kaliuresis. The first aim tested whether acutely raising plasma [K(+)] with a single 3-hour 2% potassium meal would lower NCCp in Sprague-Dawley rats after 14 days of AngII (400 ng/kg per minute). The potassium-rich meal neither decreased NCCp nor increased K(+) excretion. AngII-infused rats exhibited lower plasma [K(+)] versus controls (3.6±0.2 versus 4.5±0.1 mmol/L; P<0.05), suggesting that AngII-mediated epithelial Na(+) channel activation provokes K(+) depletion. The second aim tested whether doubling dietary potassium intake from 1% (A1K) to 2% (A2K) would prevent K(+) depletion during AngII infusion and, thus, prevent NCC accumulation. A2K-fed rats exhibited normal plasma [K(+)] and 2-fold higher K(+) excretion and plasma [aldosterone] versus A1K. In A1K rats, NCC, NCCpS71, and NCCpT53 abundance increased 1.5- to 3-fold versus controls (P<0.05). The rise in NCC and NCCp abundance was prevented in the A2K rats, yet blood pressure did not significantly decrease. Epithelial Na(+) channel subunit abundance and cleavage increased 1.5- to 3-fold in both A1K and A2K; ROMK (renal outer medulla K(+) channel abundance) abundance was unaffected by AngII or dietary K(+) In summary, the accumulation and phosphorylation of NCC seen during chronic AngII infusion hypertension is likely secondary to potassium deficiency driven by epithelial Na(+) channel stimulation. PMID:27600183

  6. Coordination of Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), Pd(II) and Pt(II) with 2,5-hexanedione bis(thiosemicarbazone), HBTS: Crystal structure of cis-[Pd(HBTS)]Cl2 and 1-(2,5-dimethyl-1H-pyrrol-yl)-thiourea

    NASA Astrophysics Data System (ADS)

    Jeragh, Bakir; El-Asmy, Ahmed A.

    2014-09-01

    Metal complexes of Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, Pd2+ or Pt2+ with 2,5-hexanedione bis(thiosemicarbazone), HBTS; have been prepared and spectroscopically investigated. The empirical formulae of the complexes were suggested based on the elemental analysis. Single crystal of Pd(II) has been solved to be cis-form of square-planar geometry by the X-ray crystallography. 1H and 13C NMR spectra have been recorded for HBTS, Zn(II), Cd(II), Hg(II), Pd(II) and Pt(II) complexes, in DMSO-d6, showing the mode of chelation. The ligand acts as a neutral or a binegative tetradentate (N2S2) or neutral bidentate on the basis of FT-IR. The magnetic moments and electronic spectra provide information about the geometry of the complexes which supported by calculating the ligand field parameters for the Co(II) and Fe(III) complexes. The Ni(II) complex has subnormal magnetic moment (0.71 BM) indicative of a mixed stereochemistry of square-planar and tetrahedral structure. [Cu(HBTS-2H)] measured 0.93 BM indicating high interaction between the copper centers. The ligand may be ordered at the top of the spectrochemical series which giving high ligand field splitting energy (10Dq = 17,900 cm-1 for Co2+ complex). The mass spectra of some complexes proved their stable chemical formulae while the TGA depicts the degradation steps and the final residue. In evaporating the mother liquor during the preparation of HBTS, new compound is obtained naming 1-(2,5-dimethyl-1H-pyrrol-yl)thiourea and its crystal was solved.

  7. Coordination of Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), Pd(II) and Pt(II) with 2,5-hexanedione bis(thiosemicarbazone), HBTS: crystal structure of cis-[Pd(HBTS)]Cl2 and 1-(2,5-dimethyl-1H-pyrrol-yl)-thiourea.

    PubMed

    Jeragh, Bakir; El-Asmy, Ahmed A

    2014-09-15

    Metal complexes of Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, Pd2+ or Pt2+ with 2,5-hexanedione bis(thiosemicarbazone), HBTS; have been prepared and spectroscopically investigated. The empirical formulae of the complexes were suggested based on the elemental analysis. Single crystal of Pd(II) has been solved to be cis-form of square-planar geometry by the X-ray crystallography. 1H and 13C NMR spectra have been recorded for HBTS, Zn(II), Cd(II), Hg(II), Pd(II) and Pt(II) complexes, in DMSO-d6, showing the mode of chelation. The ligand acts as a neutral or a binegative tetradentate (N2S2) or neutral bidentate on the basis of FT-IR. The magnetic moments and electronic spectra provide information about the geometry of the complexes which supported by calculating the ligand field parameters for the Co(II) and Fe(III) complexes. The Ni(II) complex has subnormal magnetic moment (0.71 BM) indicative of a mixed stereochemistry of square-planar and tetrahedral structure. [Cu(HBTS-2H)] measured 0.93 BM indicating high interaction between the copper centers. The ligand may be ordered at the top of the spectrochemical series which giving high ligand field splitting energy (10 Dq=17,900 cm(-1) for Co2+ complex). The mass spectra of some complexes proved their stable chemical formulae while the TGA depicts the degradation steps and the final residue. In evaporating the mother liquor during the preparation of HBTS, new compound is obtained naming 1-(2,5-dimethyl-1H-pyrrol-yl)thiourea and its crystal was solved.

  8. SVX II a silicon vertex detector for run II of the tevatron

    SciTech Connect

    Bortoletto, D.

    1994-11-01

    A microstrip silicon detector SVX II has been proposed for the upgrade of the vertex detector of the CDF experiment to be installed for run II of the Tevatron in 1998. Three barrels of four layers of double sided detectors will cover the interaction region. The requirement of the silicon tracker and the specification of the sensors are discussed together with the proposed R&D to verify the performance of the prototypes detectors produced by Sintef, Micron and Hamamatsu.

  9. RTNS-II: irradiations at the Rotating Target Neutron Source-II. 1983 annual report

    SciTech Connect

    Not Available

    1983-01-01

    This is the second annual report summarizing irradiation experiments and operations at RTNS-II. It covers calendar year 1983 and includes reports on all irradiations, non-fusion as well as fusion, and on utilization of Monbusho's transmission electron microscope (TEM) a RTNS-II. Each summary article has been submitted by the investigator and has been altered only to meet the style and format requirements of this report.

  10. Palladium(II) and platinum(II) complexes with tridentate iminophosphine ligands; synthesis and structural studies.

    PubMed

    Ní Dhubhghaill, Orla M; Lennon, Joanne; Drew, Michael G B

    2005-10-01

    The previously synthesised Schiff-base ligands 2-(2-Ph(2)PC(6)H(4)N[double bond, length as m-dash]CH)-R'-C(6)H(3)OH (R'= 3-OCH(3), HL(1); 5-OCH(3), HL(2); 5-Br, HL(3); 5-Cl, HL(4)) were prepared by a faster, more efficient route involving a microwave assisted co-condensation of 2-(diphenylphosphino)aniline with the appropriate substituted salicylaldehyde. HL(1-4) react directly with M(II)Cl(2)(M = Pd, Pt) or Pt(II)I(2)(cod) affording neutral square-planar complexes of general formula [M(II)Cl(eta(3)-L(1-4))](M = Pd, Pt, 1-8) and [Pt(II)I(eta(3)-L(1-4))](M = Pd, Pt, 9-12). Reaction of complexes 1-4 with the triarylphosphines PR(3)(R = Ph, p-tolyl) gave the novel ionic complexes [Pd(II)(PR(3))(eta(3)-L(1-4))]ClO(4)(13-20). Substituted platinum complexes of the type [Pt(II)(PR(3))(eta(3)-L(1-4))]ClO(4)(R = P(CH(2)CH(2)CN)(3)21-24) and [Pt(II)(P(p-tolyl)(3))(eta(3)-L(3,4))]ClO(4)( 25 and 26 ) were synthesised from the appropriate [Pt(II)Cl(eta(3)-L(1-4))] complex (5-8) and PR(3). The complexes are characterised by microanalytical and spectroscopic techniques. The crystal structures of 3, 6, 10, 15, 20 and 26 were determined and revealed the metal to be in a square-planar four-coordinate environment containing a planar tridentate ligand with an O,N,P donor set together with one further atom which is trans to the central nitrogen atom. PMID:16172647

  11. Immobilization of Rose Waste Biomass for Uptake of Pb(II) from Aqueous Solutions

    PubMed Central

    Ansari, Tariq Mahmood; Hanif, Muhammad Asif; Mahmood, Abida; Ijaz, Uzma; Khan, Muhammad Aslam; Nadeem, Raziya; Ali, Muhammad

    2011-01-01

    Rosa centifolia and Rosa gruss an teplitz distillation waste biomass was immobilized using sodium alginate for Pb(II) uptake from aqueous solutions under varied experimental conditions. The maximum Pb(II) adsorption occurred at pH 5. Immobilized rose waste biomasses were modified physically and chemically to enhance Pb(II) removal. The Langmuir sorption isotherm and pseudo-second-order kinetic models fitted well to the adsorption data of Pb(II) by immobilized Rosa centifolia and Rosa gruss an teplitz. The adsorbed metal is recovered by treating immobilized biomass with different chemical reagents (H2SO4, HCl and H3PO4) and maximum Pb(II) recovered when treated with sulphuric acid (95.67%). The presence of cometals Na, Ca(II), Al(III), Cr(III), Cr(VI), and Cu(II), reduced Pb(II) adsorption on Rosa centifolia and Rosa gruss an teplitz waste biomass. It can be concluded from the results of the present study that rose waste can be effectively used for the uptake of Pb(II) from aqueous streams. PMID:21350666

  12. Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules

    PubMed Central

    Harton, Jonathan; Jin, Lei; Hahn, Amy; Drake, Jim

    2016-01-01

    Major histocompatibility complex (MHC) class II molecules present exogenously derived antigen peptides to CD4 T cells, driving activation of naïve T cells and supporting CD4-driven immune functions. However, MHC class II molecules are not inert protein pedestals that simply bind and present peptides. These molecules also serve as multi-functional signaling molecules delivering activation, differentiation, or death signals (or a combination of these) to B cells, macrophages, as well as MHC class II-expressing T cells and tumor cells. Although multiple proteins are known to associate with MHC class II, interaction with STING (stimulator of interferon genes) and CD79 is essential for signaling. In addition, alternative transmembrane domain pairing between class II α and β chains influences association with membrane lipid sub-domains, impacting both signaling and antigen presentation. In contrast to the membrane-distal region of the class II molecule responsible for peptide binding and T-cell receptor engagement, the membrane-proximal region (composed of the connecting peptide, transmembrane domain, and cytoplasmic tail) mediates these “non-traditional” class II functions. Here, we review the literature on the function of the membrane-proximal region of the MHC class II molecule and discuss the impact of this aspect of class II immunobiology on immune regulation and human disease. PMID:27006762

  13. Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules.

    PubMed

    Harton, Jonathan; Jin, Lei; Hahn, Amy; Drake, Jim

    2016-01-01

    Major histocompatibility complex (MHC) class II molecules present exogenously derived antigen peptides to CD4 T cells, driving activation of naïve T cells and supporting CD4-driven immune functions. However, MHC class II molecules are not inert protein pedestals that simply bind and present peptides. These molecules also serve as multi-functional signaling molecules delivering activation, differentiation, or death signals (or a combination of these) to B cells, macrophages, as well as MHC class II-expressing T cells and tumor cells. Although multiple proteins are known to associate with MHC class II, interaction with STING (stimulator of interferon genes) and CD79 is essential for signaling. In addition, alternative transmembrane domain pairing between class II α and β chains influences association with membrane lipid sub-domains, impacting both signaling and antigen presentation. In contrast to the membrane-distal region of the class II molecule responsible for peptide binding and T-cell receptor engagement, the membrane-proximal region (composed of the connecting peptide, transmembrane domain, and cytoplasmic tail) mediates these "non-traditional" class II functions. Here, we review the literature on the function of the membrane-proximal region of the MHC class II molecule and discuss the impact of this aspect of class II immunobiology on immune regulation and human disease. PMID:27006762

  14. Synthesis, antimicrobial activity, structural and spectral characterization and DFT calculations of Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile.

    PubMed

    Mohamed, Tarek A; Shaaban, Ibrahim A; Farag, Rabei S; Zoghaib, Wajdi M; Afifi, Mahmoud S

    2015-01-25

    Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile (APC) have been synthesized and characterized using elemental analysis, magnetic susceptibility, mass spectrometry, infrared (4000-200 cm(-1)), UV-Visible (200-1100 nm), (1)H NMR and ESR spectroscopy as well as TGA analysis. The molar conductance measurements in DMSO imply non-electrolytic complexes, formulated as [M(APC)2Cl2] where M=Co(II), Ni(II), Cu(II) and Pd(II). The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor. The magnetic measurements and the electronic absorption spectra support distorted octahedral geometries for Co(II), Ni(II) and Cu(II) complexes however a square planar complex was favored for the Pd(II) complex (C2h skeleton symmetry). In addition, we carried out B3LYP and ω-B97XD geometry optimization at 6-31G(d) basis set except for Pd(II) where we implemented LanL2DZ/6-31G(d) combined basis set. The computational results favor all trans geometrical isomers where amino N, pyrimidine N and Cl are trans to each other (structure 1). Finally, APC and its divalent metal ion complexes were screened for their antibacterial activity, and the synthesized complexes were found to be more potent antimicrobial agents than APC against one or more microbial species. PMID:25105264

  15. Synthesis, antimicrobial activity, structural and spectral characterization and DFT calculations of Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile.

    PubMed

    Mohamed, Tarek A; Shaaban, Ibrahim A; Farag, Rabei S; Zoghaib, Wajdi M; Afifi, Mahmoud S

    2015-01-25

    Co(II), Ni(II), Cu(II) and Pd(II) complexes of 4-amino-5-pyrimidinecarbonitrile (APC) have been synthesized and characterized using elemental analysis, magnetic susceptibility, mass spectrometry, infrared (4000-200 cm(-1)), UV-Visible (200-1100 nm), (1)H NMR and ESR spectroscopy as well as TGA analysis. The molar conductance measurements in DMSO imply non-electrolytic complexes, formulated as [M(APC)2Cl2] where M=Co(II), Ni(II), Cu(II) and Pd(II). The infrared spectra of Co(II), Ni(II) and Cu(II) complexes indicate a bidentate type of bonding for APC through the exocyclic amino and adjacent pyrimidine nitrogen as donors whereas APC coordinated to Pd(II) ion as a monodentated ligand via a pyrimidine nitrogen donor. The magnetic measurements and the electronic absorption spectra support distorted octahedral geometries for Co(II), Ni(II) and Cu(II) complexes however a square planar complex was favored for the Pd(II) complex (C2h skeleton symmetry). In addition, we carried out B3LYP and ω-B97XD geometry optimization at 6-31G(d) basis set except for Pd(II) where we implemented LanL2DZ/6-31G(d) combined basis set. The computational results favor all trans geometrical isomers where amino N, pyrimidine N and Cl are trans to each other (structure 1). Finally, APC and its divalent metal ion complexes were screened for their antibacterial activity, and the synthesized complexes were found to be more potent antimicrobial agents than APC against one or more microbial species.

  16. DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation

    SciTech Connect

    Chen, Zirong; Jin, Guorong; Lin, Shuibin; Lin, Xiumei; Gu, Yumei; Zhu, Yujuan; Hu, Chengbin; Zhang, Qingjiong; Wu, Lizi; Shen, Huangxuan

    2012-06-08

    Highlights: Black-Right-Pointing-Pointer CDA-II inhibits myogenic differentiation in a dose-dependent manner. Black-Right-Pointing-Pointer CDA-II repressed expression of muscle transcription factors and structural proteins. Black-Right-Pointing-Pointer CDA-II inhibited proliferation and migration of C2C12 myoblasts. -- Abstract: CDA-II (cell differentiation agent II), isolated from healthy human urine, is a DNA methyltransferase inhibitor. Previous studies indicated that CDA-II played important roles in the regulation of cell growth and certain differentiation processes. However, it has not been determined whether CDA-II affects skeletal myogenesis. In this study, we investigated effects of CDA-II treatment on skeletal muscle progenitor cell differentiation, migration and proliferation. We found that CDA-II blocked differentiation of murine myoblasts C2C12 in a dose-dependent manner. CDA-II repressed expression of muscle transcription factors, such as Myogenin and Mef2c, and structural proteins, such as myosin heavy chain (Myh3), light chain (Mylpf) and MCK. Moreover, CDA-II inhibited C1C12 cell migration and proliferation. Thus, our data provide the first evidence that CDA-II inhibits growth and differentiation of muscle progenitor cells, suggesting that the use of CDA-II might affect skeletal muscle functions.

  17. LINE EMISSION FROM RADIATION-PRESSURIZED H II REGIONS. II. DYNAMICS AND POPULATION SYNTHESIS

    SciTech Connect

    Verdolini, Silvia; Tielens, Alexander G. G. M.; Yeh, Sherry C. C.; Matzner, Christopher D.; Krumholz, Mark R.

    2013-05-20

    Optical and infrared emission lines from H II regions are an important diagnostic used to study galaxies, but interpretation of these lines requires significant modeling of both the internal structure and dynamical evolution of the emitting regions. Most of the models in common use today assume that H II region dynamics are dominated by the expansion of stellar wind bubbles, and have neglected the contribution of radiation pressure to the dynamics, and in some cases also to the internal structure. However, recent observations of nearby galaxies suggest that neither assumption is justified, motivating us to revisit the question of how H II region line emission depends on the physics of winds and radiation pressure. In a companion paper we construct models of single H II regions including and excluding radiation pressure and winds, and in this paper we describe a population synthesis code that uses these models to simulate galactic collections of H II regions with varying physical parameters. We show that the choice of physical parameters has significant effects on galactic emission line ratios, and that in some cases the line ratios can exceed previously claimed theoretical limits. Our results suggest that the recently reported offset in line ratio values between high-redshift star-forming galaxies and those in the local universe may be partially explained by the presence of large numbers of radiation-pressure-dominated H II regions within them.

  18. Synthesis, structural elucidation and carbon dioxide adsorption on Zn (II) hexacyanoferrate (II) Prussian blue analogue

    NASA Astrophysics Data System (ADS)

    Roque-Malherbe, R.; Lugo, F.; Polanco, R.

    2016-11-01

    In the course of the last years hexacyanoferrates have been widely studied; even though, the adsorption properties of Zn (II) hexacyanoferrate(II) (labelled here Zn-HII) have not been thoroughly considered. In addition, soft porous crystals, i.e., adsorbents that display structural flexibility have been, as well, extensively studied, however this property has not been reported for Zn (II) hexacyanoferrate(II). In this regard, the key questions addressed here were the synthesis and structural characterization of Zn-HII together with the investigation of their low (up to 1 bar) and high pressure (up to 30 bar) adsorption properties, to found if these materials show structural flexibility. Then, to attain the anticipated goals, structural characterizations were made with: X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), diffuse reflectance infrared Fourier transform spectrometry (DRIFTS) and thermo-gravimetric analysis (TGA), simultaneously, with the investigation of the adsorption of carbon dioxide. As a result of the research process we concluded that the Zn-HII displayed Fm barm space group framework. Besides, the carbon dioxide adsorption investigation demonstrated the presence of the framework expansion effect together with an extremely high adsorption heat, properties that could be useful for the use of Zn(II) hexacyanoferrate(II) as an excellent adsorbent.

  19. Titanium dioxide mediated photocatalysis of Pb(II)- and Co(II)-EDTA complexes

    SciTech Connect

    Davis, A.P.; Vohra, M.S.; Ayres, D.M.

    1995-12-31

    The photocatalysis of lead and cobalt(II) complexed to EDTA was evaluated under a variety of experimental conditions. Adsorption characteristics of the metals and the metal complexes were also determined. A recirculating batch system was used to quantify photocatalytic oxidation rates. EDTA mineralization and total dissolved metal were monitored. Separations of Co(II*), Co(II)-EDTA, and Co(III)-EDTA were made with a method using Dowex cation exchange resin. Adsorptions of Pb(II), Co(II), EDTA, and the corresponding metal complexes was examined using concentrations of 10{sup -}{sup 5} to 10{sup -}{sup 3} M in 2 g/L TiO{sub 2}. After purging and pH adjustment, the samples were shaken overnight. The final pH and metal and TOC concentrations were determined. Results showed that the photocatablytic oxidation of metal-EDTA complexes is independent of pH from 5 to 7. This contrasts with the adsorption of these species onto TiO{sub 2}, which decreases at neutral-high pH, suggesting that adsorption is not a prerequisite to photocalysis. For Co(II)-EDTA, a competing pH dependent conversion to Co(III)-EDTA is noted.

  20. Potential future applications for the tracking and data relay satellite II (TDRS II) system

    NASA Technical Reports Server (NTRS)

    Gibbons, Richard C.

    1995-01-01

    During the conceptual design phases of the tracking and data relay satellite (TDRS) II system provision was made for a future service growth (FSG) payload with an undefined mission. The intent of the FSG was to provide a resource for TDRS II applications which would be available to meet a change in requirements for the operational TDRS II system. This paper summarizes the effect of the consideration of potential FSG applications imposed on the tracking and data relay satellite (TDRS) II system. The following applications were considered as FSG candidates: An optical 650 Mbps space-to-space link (SSL) coupled to an optical or RF downlink, an RF or optical crosslink to extend the baseline TDRS II system coverage, -zone of exclusion (ZOE) closure, relay for lunar communications either RF or optically, and relay for Martian communications either RF or optically. This paper summarizes work done in the 1990 time frame on the above stated applications. Since then, NASA has sponsored several studies (during phase B of the TDRS II development cycle) of the ZOE closure application of the FSG. The purpose of this paper is to report on the efforts previously considered for the FSG. A previous paper was presented at the 1991 Congress related to the second application above. This paper extends this effort to the four stated applications.

  1. Electroweak Prospects for Tevatron RunII

    SciTech Connect

    D. Glenzinski

    2002-10-21

    In RunI each experiment collected about 100 pb{sup -1} of data. During RunIIa, each experiment is expected to collect about 2 fb{sup -1} of data. The center-of-mass energy for RunII, {radical}s = 2.0 TeV, is a bit larger than the 1.8 TeV of RunI and results in an increase of about 10% (35%) in the production cross-sections for W and Z (t{bar t}) events. Additional gains in the event yield are expected due to improvements in the detector acceptance and performance. Taken together, the RunIIa upgrades are expected to yield 2300k (800) W (t{bar t}) events per experiment, including the effects of event selection and triggering, which can be compared to the RunI yields of 77k (20) events. With the RunI data-set, CDF and D0 produced a breadth of electroweak results and obtained the world's only sample of top quarks. While the RunII electroweak physics program is very similar, the RunII upgrade improvements should yield many precision results. The Tevatron began delivering steady data in about June, 2001. The first six months of data taking was ''commissioning dominated'' for CDF and D0. Starting around January, 2002, the experiments were largely commissioned and began taking ''analysis quality'' data. The physics results reported at this conference are based on about 10-20pb{sup -1} (depending on the data-set) per experiment. Thus, the presently available event samples are smaller than those available in RunI. At this early stage of RunII, it is interesting to compare the present detector performance to that assumed when making the RunII physics projections. In the following sections the author discusses some RunII projections for a few electroweak measurements of particular importance, namely the precision determinations of the W-boson mass, M{sub W}, and the top-quark mass, M{sub t}.

  2. The metallomics approach: use of Fe(II) and Cu(II) footprinting to examine metal binding sites on serum albumins.

    PubMed

    Duff, Michael R; Kumar, Challa V

    2009-11-01

    Metal binding to serum albumins is examined by oxidative protein-cleavage chemistry, and relative affinities of multiple metal ions to particular sites on these proteins were identified using a fast and reliable chemical footprinting approach. Fe(ii) and Cu(ii), for example, mediate protein cleavage at their respective binding sites on serum albumins, in the presence of hydrogen peroxide and ascorbate. This metal-mediated protein-cleavge reaction is used to evaluate the binding of metal ions, Na(+), Mg(2+), Ca(2+), Al(3+), Cr(3+), Mn(2+), Co(2+), Ni(2+), Zn(2+), Cd(2+), Hg(2+), Pb(2+), and Ce(3+) to albumins, and the relative affinities (selectivities) of the metal ions are rapidly evaluated by examining the extent of inhibition of protein cleavage. Four distinct systems Fe(II)/BSA, Cu(II)/BSA, Fe(II)/HSA and Cu(II)/HSA are examined using the above strategy. This metallomics approach is novel, even though the cleavage of serum albumins by Fe(II)/Cu(II) has been reported previously by this laboratory and many others. The protein cleavage products were analyzed by SDS PAGE, and the intensities of the product bands quantified to evaluate the extent of inhibition of the cleavage and thereby evaluate the relative binding affinities of specific metal ions to particular sites on albumins. The data show that Co(II) and Cr(III) showed the highest degree of inhibition, across the table, followed by Mn(II) and Ce(III). Alakali metal ions and alkaline earth metal ions showed very poor affinity for these metal sites on albumins. Thus, metal binding profiles for particular sites on proteins can be obtained quickly and accurately, using the metallomics approach.

  3. Synthesis, spectroscopic characterization and biological activities of N4O2 Schiff base ligand and its metal complexes of Co(II), Ni(II), Cu(II) and Zn(II)

    NASA Astrophysics Data System (ADS)

    Al-Resayes, Saud I.; Shakir, Mohammad; Abbasi, Ambreen; Amin, Kr. Mohammad Yusuf; Lateef, Abdul

    The Schiff base ligand, bis(indoline-2-one)triethylenetetramine (L) obtained from condensation of triethylenetetramine and isatin was used to synthesize the complexes of type, [ML]Cl2 [M = Co(II), Ni(II), Cu(II) and Zn(II)]. L was characterized on the basis of the results of elemental analysis, FT-IR, 1H and 13C NMR, mass spectroscopic studies. The stoichiometry, bonding and stereochemistries of complexes were ascertained on the basis of results of elemental analysis, magnetic susceptibility values, molar conductance and various spectroscopic studies. EPR, UV-vis and magnetic moments revealed an octahedral geometry for complexes. L and its Cu(II) and Zn(II) complexes were screened for their antibacterial activity. Analgesic activity of Cu(II) and Zn(II) complexes was also tested in rats by tail flick method. Both complexes were found to possess good antibacterial and moderate analgesic activity.

  4. Synthesis, spectroscopic characterization, molecular modeling and antimicrobial activities of Mn(II), Co(II), Ni(II), Cu(II) complexes containing the tetradentate aza Schiff base ligand

    NASA Astrophysics Data System (ADS)

    Chandra, Sulekh; Ruchi

    2013-02-01

    Mn(II), Co(II), Ni(II), and Cu(II) complexes with a tetradentate macrocyclic ligand [1.2.5.6tetraoxo-3,4,7,8tetraaza-(1,2,3,4,5,6,7,8)tetrabenzene(L)] were synthesized and characterized by elemental analysis, molar conductance measurements, mass, nmr, i.r., electronic and e.p.r. spectral studies. All the complexes are non electrolytes in nature and may be formulated as [M(L)X2] [where, M = Mn(II), Co(II), Ni(II), Cu(II) and X = Cl-, CH3COO-]. On the basis of i.r., electronic and e.p.r. spectral studies a distorted octahedral geometry has been assigned for all complexes. The antimicrobial activities and LD50 values of the ligand and its complexes, as growth inhibiting agents, have been screened in vitro against two different species of bacteria and plant pathogenic fungi.

  5. Adsorption of Co(II), Ni(II), Cu(II), and Zn(II) on hexagonal templated zirconia obtained thorough a sol-gel process: the effects of nanostructure on adsorption features.

    PubMed

    de Farias, Robson F; do Nascimento, Ana A S; Bezerra, Cícero W B

    2004-09-01

    Using zirconium tetrabutoxide, diaminedecane, and diamineoctane as precursors, a templated hexagonal zirconia matrix is synthesized and characterized by X-ray diffractometry and scanning electron microscopy. The adsorption capacity of such a matrix toward Co(II), Ni(II), Cu(II), and Zn(II) from aqueous solutions is studied. The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)>Zn(II) >Ni(II)>Co(II). It is also verified that the adsorption of the cations follows a Langmuir and not a Freundlich isotherm. All obtained isotherms are of type I, according to the IUPAC classification. The observed adsorption affinity sequence can be explained by taking into account the velocity constant for the substitution of water molecules into the cation coordination spheres, as well as the Irving-Williams series.

  6. Genetics Home Reference: microcephalic osteodysplastic primordial dwarfism type II

    MedlinePlus

    ... Genetics Home Health Conditions MOPDII microcephalic osteodysplastic primordial dwarfism type II Enable Javascript to view the expand/ ... Open All Close All Description Microcephalic osteodysplastic primordial dwarfism type II ( MOPDII ) is a condition characterized by ...

  7. Adsorption of Co(II), Ni(II), Cu(II), and Zn(II) on hexagonal templated zirconia obtained thorough a sol-gel process: the effects of nanostructure on adsorption features.

    PubMed

    de Farias, Robson F; do Nascimento, Ana A S; Bezerra, Cícero W B

    2004-09-01

    Using zirconium tetrabutoxide, diaminedecane, and diamineoctane as precursors, a templated hexagonal zirconia matrix is synthesized and characterized by X-ray diffractometry and scanning electron microscopy. The adsorption capacity of such a matrix toward Co(II), Ni(II), Cu(II), and Zn(II) from aqueous solutions is studied. The adsorption affinity of the synthesized hexagonal templated zirconia toward the cations is Cu(II)>Zn(II) >Ni(II)>Co(II). It is also verified that the adsorption of the cations follows a Langmuir and not a Freundlich isotherm. All obtained isotherms are of type I, according to the IUPAC classification. The observed adsorption affinity sequence can be explained by taking into account the velocity constant for the substitution of water molecules into the cation coordination spheres, as well as the Irving-Williams series. PMID:15276032

  8. SAM II Data and Information (HDF-EOS)

    Atmospheric Science Data Center

    2016-09-01

    SAM II Data and Information (HDF-EOS) Data obtained from the Stratospheric Aerosol Measurement (SAM) II instrument, ... Guide Documents:  Project Guide Data Set Guide Readme Files:  Data Set (Text file) ...

  9. Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart.

    PubMed

    Grace, A A; Metcalfe, J C; Weissberg, P L; Bethell, H W; Vandenberg, J I

    1996-06-01

    The Na+/H+ antiport and Na(+)-HCO3- coinflux carrier contribute to recovery from intracellular acidosis in cardiac tissue. The effects of angiotensin II (10(-12)-10(-6) M) on H+ fluxes after intracellular acid loading and during reperfusion after myocardial ischemia have been investigated in the isovolumic, Langendorff-perfused ferret heart. Intracellular pH (pHi) was estimated using 31P nuclear magnetic resonance (NMR) spectroscopy from the chemical shift of intracellular deoxyglucose-6-phosphate or inorganic phosphate. Angiotensin II produced concentration-dependent stimulation (maximum at 10(-6) M: 67%) of 5-(N-ethyl-N-isopropyl)amiloride (EIPA)-sensitive Na(+)-dependent of H+ efflux consistent with stimulation of the Na+/H+ antiport. Half-maximal stimulation of H+ efflux occurred at approximately 10(-9) M, which is close to the dissociation constant of the cardiac angiotensin AT1 receptor. Stimulation via this receptor was confirmed with the nonpeptide AT1 receptor blocker, GR-117289. Angiotensin II had less pronounced effects on HCO3(-)-dependent pHi recovery after acid loading with no effect on pHi recovery after intracellular alkalosis. During reperfusion, angiotensin II significantly increased H+ extrusion but impaired contractile recovery. The results support the hypothesis that angiotensin II facilitates H+ extrusion in the heart. This may help maintain physiological homeostasis, but the hypothesized obligated Na+ influx could exacerbate cellular dysfunction during reperfusion. PMID:8764151

  10. 1996 Site environmental report. Volume II

    SciTech Connect

    1997-09-01

    Ernest Orlando Lawrence Berkeley National Laboratory presents Volume II, data appendix as a reference document to supplement the 1996 Site Environmental Report. Volume II contains the raw environmental monitoring and sampling data used to generate many of the summary results included in the main report for both routine and nonroutine activities. This appendix includes a legend that cross-references the enclosed data tables with summary tables in the main report. The legend also provides a listing of more detailed descriptions for the station location codes used in the appendices` tables. Data presented in the tables are given in Systeme International (SI) units. The glossary found in the main report contains a listing of the SI units.

  11. Observationally determined Fe II oscillator strengths

    NASA Astrophysics Data System (ADS)

    Shull, J. M.; van Steenberg, M.; Seab, C. G.

    1983-08-01

    Absorption oscillator strengths for 21 Fe II resonance lines, have been determined using a curve-of-growth analysis of interstellar data from the Copernicus and International Ultraviolet Explorer (IUE) satellites. In addition to slight changes in strengths of the far-UV lines, new f-values are reported for wavelength 1608.45, a prominent line in interstellar and quasar absorption spectra, and for wavelength 2260.08, a weak, newly identified linen in IUE interstellar spectra. An upper limit on the strength of the undetected line at 2366.867 A (UV multiplet 2) is set. Using revised oscillator strengths, Fe II column densities toward 13 OB stars are derived. The interstellar depletions, (Fe/H), relative to solar values range between factors of 10 and 120.

  12. Dust in MG II Absorption Systems

    NASA Astrophysics Data System (ADS)

    Malhotra, S.

    The dust absorption feature at 2175 AA is detected in a composite spectrum of Mg II absorbers. The composite absorber spectrum is obtained by taking the geometric mean of 92 quasar spectra after aligning them in the rest-frame of 96 absorbers. By aligning the spectra according to absorber redshifts we reinforce the spectral features of the absorbers, and smooth over possible bumps and wiggles in the emission spectra. The width of the observed absorption feature is 200-300 AA (FWHM), or 0.4-0.6 microns^{-1} and the central wavelength is 2240 AA. The Galactic dust feature has a central wavelength of 2176 AA and FWHM = 0.8-1.25 microns^{-1}. Simulations show that this discrepancy between the properties of the 2175 AA feature in Mg II absorbers and Galactic ISM can be mostly explained by the different methods used to measure them (cf. Malhotra 1997).

  13. Cu(II) Promotes Amyloid Pore Formation

    PubMed Central

    Zhang, Hangyu; Rochet, Jean-Christophe; Stanciu, Lia A

    2015-01-01

    The aggregation of α-synuclein is associated with dopamine neuron death in Parkinson's disease. There is controversy in the field over the question of which species of the aggregates, fibrils or protofibrils, are toxic. Moreover, compelling evidence suggested the exposure to heavy metals to be a risk of PD. Nevertheless, the mechanism of metal ions in promoting PD remains unclear. In this research, we investigated the structural basis of Cu(II) induced aggregation of α-synuclein. Using transmission electron microscopy experiments, Cu(II) was found to promote in vitro aggregation of α-synuclein by facilitating annular protofibril formation rather than fibril formation. Furthermore, neuroprotective baicalein disaggregated annular protofibrils accompanied by considerable decrease of β-sheet content. These results strongly support the hypothesis that annular protofibrils are the toxic species, rather than fibrils, thereby inspiring us to search novel therapeutic strategies for the suppression of the toxic annular protofibril formation. PMID:26129772

  14. INITIAL COMMISSIONING OF NDCX-II

    SciTech Connect

    Lidia, S.; Arbelaez, D.; Greenway, W.; Jung, J. -Y.; Kwan, J.; Lipton, T.; Pekedis, A.; Roy, P.; Seidl, P.; Takakuwa, J.; Waldron, W.; Friedman, A.; Grote, D.; Sharp, W.; Gilson, E.

    2012-05-15

    The Neutralized Drift Compression Experiment-II (NDCX-II) will generate ion beam pulses for studies of Warm Dense Matter and heavy-ion-driven Inertial Fusion Energy. The machine will accelerate 20-50 nC of Li+ to 1.2-3 MeV energy, starting from a 10.9-cm alumino-silicate ion source. At the end of the accelerator the ions are focused to a sub-mm spot size onto a thin foil (planar) target. The pulse duration is compressed from ~;;500 ns at the source to sub-ns at the target following beam transport in a neutralizing plasma. We first describe the injector, accelerator, transport, final focus and diagnostic facilities. We then report on the results of early commissioning studies that characterize beam quality and beam transport, acceleration waveform shaping and beam current evolution. We present simulation results to benchmark against the experimental measurements.

  15. Inert doublet model and LEP II limits

    SciTech Connect

    Lundstroem, Erik; Gustafsson, Michael; Edsjoe, Joakim

    2009-02-01

    The inert doublet model is a minimal extension of the standard model introducing an additional SU(2) doublet with new scalar particles that could be produced at accelerators. While there exists no LEP II analysis dedicated for these inert scalars, the absence of a signal within searches for supersymmetric neutralinos can be used to constrain the inert doublet model. This translation however requires some care because of the different properties of the inert scalars and the neutralinos. We investigate what restrictions an existing DELPHI Collaboration study of neutralino pair production can put on the inert scalars and discuss the result in connection with dark matter. We find that although an important part of the inert doublet model parameter space can be excluded by the LEP II data, the lightest inert particle still constitutes a valid dark matter candidate.

  16. Phenoxide bridged tetranuclear Co(II), Ni(II), Cu(II) and Zn(II) complexes: Electrochemical, magnetic and antimicrobial studies

    NASA Astrophysics Data System (ADS)

    Kamath, Anupama; Kulkarni, Naveen V.; Netalkar, Priya P.; Revankar, Vidyanand K.

    2011-09-01

    Phenoxide bridged later first row transition metal(II) complexes have been prepared by the interaction of later 3d transition metal(II) chlorides with tetranucleating compartmental Schiff base ligand system derived from 2,6-diformyl-4-methylphenol, p-phenylenediamine and 2-hydrazinobenzothiazole. Ligand and complexes were characterized by analytical, spectral (IR, UV-visible, ESR, FAB-mass and fluorescence), magnetic and thermal studies. All complexes are found to have octahedral geometry. The mutual influence of metal centres in terms of cooperative effect on the electronic, magnetic, electrochemical and structural properties was investigated. The Schiff base and its complexes have been screened for their antibacterial (against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa) and antifungal activities (against Aspergillus niger, and Candida albicans).

  17. KEKB and PEP-II B Factories

    SciTech Connect

    Seeman, J.T.

    1997-01-01

    Two asymmetric B-Factories KEKB at KEK and PEP-II at SLAC are under construction, designed to study CP violation in the b-quark sector with a center of mass energy of 10.58 GeV. These two new accelerators are high luminosity two-ring two-energy e{sup +}e{sup {minus}} colliders with one interaction point. There are many challenging accelerator physics and engineering issues associated with the high beam currents and high luminosities of these rings. The chosen solutions to these issues and the general parameters of the two rings are described in detail side-by-side. KEKB and PEP-II are well into the installation phase and are both scheduled to be completed in 1998. The particle physics programs are scheduled to start in 1999.

  18. Magnetization of anisotropic Type II superconductors

    SciTech Connect

    Mints, R.G.

    1989-04-10

    Peculiarities of magnetization of anisotropic type II superconductors are of considerable interest in view of the discovery of high-T/sub c/ superconductors characterized by strongly asymmetric layered structure. Specifics of the penetration of magnetic flux into an anisotropic type II superconductor were discussed in the literature. This analysis gave the distribution of induction in an isolated vortex, its energy, and critical magnetic field H/sub c1/. However, the magnetization curve of anisotropic superconductors was not considered. This paper deals with the magnetic moment of uniaxial London superconductor in the interval H/sub c1/ /le/ H/sub 0/ << H/sub c2/, where H/sub 0/ is the external magnetic field strength.

  19. BLOT II Ver.1.39

    2003-06-03

    BLOT II is a graphic program for post-processing finite element analyses output in the EXODUS II database format. It is command driven with free-format input and can drive graphics devices supported by the Sandia Virtual Device Interface. BLOT produces mesh plots of the analysis output variables including deformed mesh plots, line contours, filled (painted) contours, vector plots of two/three variables (velocity vectors), and symbol plots of scalar variables (discrete cracks). Features include pathlines of analysismore » variables drawn on the mesh, element selection by material, element birth and death, multiple views combining several displays on each plot, symmetry mirroring, and node and element numbering. X-Y plots of the analysis variables include time vs. variable plots or variable vs. variable plots, and distance vs. variable plots at selected time stips where distance is the accumulated distance between pairs of nodes or element centers.« less

  20. Regiones H II alrededor de estrellas WR

    NASA Astrophysics Data System (ADS)

    Giménez Benitez, S.; Niemela, V.

    En base a observaciones espectroscópicas en el rango óptico, obtenidas en el CASLEO, se estudian las condiciones físicas de tres regiones H II alrededor de estrellas WR: N76 en el entorno de Ab7, en la Nube Menor de Magallanes, N79 alrededor de Br 2, en la Nube Mayor de Magallanes y G2.4+1.4 alrededor de WR 102, en nuestra Galaxia. Estas regiones presentan una alta ionización. Se observa la línea nebular de HeII en 4686 Å . Utilizando líneas nebulares de diagnóstico, se derivan los valores de la densidad y la temperatura electrónica, así como también las abundancias de algunos de los elementos químicos nebulares.