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Sample records for iii open study

  1. An open, phase III study of lanreotide (Somatuline PR) in the treatment of acromegaly.

    PubMed

    Lin, J D; Lee, S T; Weng, H F

    1999-02-01

    Acromegaly is a disorder caused by excessive secretion of human growth hormone (GH). Somatostatin and its analogue-prolonged release formulation, lanreotide (Somatuline PR), inhibit the secretion of growth hormone. The aim of this open Phase III study was to investigate the clinical efficacy of lanreotide in the treatment of six acromegalic patients with a mean age of 44 +/- 13 yr including two patients with diabetes mellitus. All the patients previously received transsphenoidal or transcranial hypophysectomy. Lanreotide was given intramuscularly every 2 weeks at a fixed dose of 30 mg for 12 weeks. Serum GH and insulin-like growth factor-I (IGF-I) levels were evaluated before, 2, 6 and 12 weeks after treatment. After 12 weeks of treatment, mean (+/- SEM) GH levels decreased from 24.8 +/- 12.5 to 6.9 +/- 3.3 ng/ml and mean serum IGF-I levels decreased from 689 +/- 282 to 430 +/- 216 ng/ml. Abdominal ultrasonographic examinations showed no gallbladder stone or bile sand formation before or after the treatment. Three of the patients who did not receive octreotide presented with manifestations of mild gastrointestinal adverse effect such as mild abdominal pain and diarrhea. In conclusion, lanreotide is effective in the treatment of active postoperative acromegaly. PMID:10426587

  2. Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study

    PubMed Central

    Xu, Yichen; Chen, Yanzhi

    2015-01-01

    Abstract Objectives: This open-label, prospective, phase I/II trial was performed to establish the safety and efficacy of Traditional Chinese Medicine (TCM) herbal products for treating non–anemia-related fatigue in patients with cancer. Although this practice is widespread in China, it has not been confirmed in a prospective clinical study. Design: Thirty-three patients who had completed cancer treatment, had stable disease and no anemia, and reported moderate to severe fatigue (rated ≥4 on a 0–10 scale) were enrolled in a TCM outpatient clinic. Patients took Ren Shen Yangrong Tang (RSYRT) decoction, a soup containing 12 TCM herbs, twice a day for 6 weeks. RSYRT aims to correct qi deficiency. Fatigue was assessed before and after RSYRT therapy, which all patients completed. Results: No discomfort or toxicity was observed. Before the study, all patients had had fatigue for at least 4 months. Fatigue severity decreased significantly from before therapy to 6 weeks after therapy: from 7.06 to 3.30 on a 0–10 scale (p<0.001). Fatigue category (mild, moderate, severe) shifted significantly (p=0.024): Of 22 patients with severe fatigue (rated ≥7) before therapy, 11 had mild fatigue and 11 had moderate fatigue after TCM treatment. The time-to-fatigue-alleviation was 2–3 weeks. Conclusion: RSYRT therapy was safe and was associated with fatigue improvement in nonanemic cancer survivors, consistent with historical TCM clinical practice experience. Because of a possible placebo effect in this open-label study, decoction RSYRT warrants further study in randomized clinical trials to confirm its effectiveness for managing moderate to severe fatigue. PMID:25918996

  3. Open-label, randomized, comparative, phase III study on effects of reducing steroid use in combination with Palonosetron.

    PubMed

    Komatsu, Yoshito; Okita, Kenji; Yuki, Satoshi; Furuhata, Tomohisa; Fukushima, Hiraku; Masuko, Hiroyuki; Kawamoto, Yasuyuki; Isobe, Hiroshi; Miyagishima, Takuto; Sasaki, Kazuaki; Nakamura, Michio; Ohsaki, Yoshinobu; Nakajima, Junta; Tateyama, Miki; Eto, Kazunori; Minami, Shinya; Yokoyama, Ryoji; Iwanaga, Ichiro; Shibuya, Hitoshi; Kudo, Mineo; Oba, Koji; Takahashi, Yasuo

    2015-07-01

    The purpose of this study is to compare the efficacy of a single administration of dexamethasone (DEX) on day 1 against DEX administration on days 1-3 in combination with palonosetron (PALO), a second-generation 5-HT3 receptor antagonist, for chemotherapy-induced nausea and vomiting (CINV) in non-anthracycline and cyclophosphamide (AC) moderately-emetogenic chemotherapy (MEC). This phase III trial was conducted with a multi-center, randomized, open-label, non-inferiority design. Patients who received non-AC MEC as an initial chemotherapy were randomly assigned to either a group administered PALO (0.75 mg, i.v.) and DEX (9.9 mg, i.v.) prior to chemotherapy (study treatment group), or a group administered additional DEX (8 mg, i.v. or p.o.) on days 2-3 (control group). The primary endpoint was complete response (CR) rate. The CR rate difference was estimated by logistic regression with allocation factors as covariates. The non-inferiority margin was set at -15% (study treatment group - control group). From April 2011 to March 2013, 305 patients who received non-AC MEC were randomly allocated to one of two study groups. Overall, the CR rate was 66.2% in the study treatment group (N = 151) and 63.6% in the control group (N = 154). PALO plus DEX day 1 was non-inferior to PALO plus DEX days 1-3 (difference, 2.5%; 95% confidence interval [CI]: -7.8%-12.8%; P-value for non-inferiority test = 0.0004). There were no differences between the two groups in terms of complete control rate (64.9 vs 61.7%) and total control rate (49.7% vs 47.4%). Anti-emetic DEX administration on days 2-3 may be eliminated when used in combination with PALO in patients receiving non-AC MEC.

  4. A randomized Phase III trial of thoracoscopic versus open esophagectomy for thoracic esophageal cancer: Japan Clinical Oncology Group Study JCOG1409.

    PubMed

    Kataoka, Kozo; Takeuchi, Hiroya; Mizusawa, Junki; Ando, Masahiko; Tsubosa, Yasuhiro; Koyanagi, Kazuo; Daiko, Hiroyuki; Matsuda, Satoru; Nakamura, Kenichi; Kato, Ken; Kitagawa, Yuko

    2016-02-01

    A randomized Phase III study was commenced in May 2015 to confirm the non-inferiority of thoracoscopic esophagectomy to open esophagectomy in terms of overall survival for clinical Stage I-III esophageal cancer. A total of 300 patients will be accrued from Japanese institutions over 6 years. The primary endpoint is overall survival. The secondary endpoints are relapse-free survival, proportion of patients with R0 resection, proportion of patients who underwent re-operation, adverse events, postoperative respiratory function change, postoperative quality-of-life score (EORTC QLQ-C30), and proportion of patients who need conversion from thoracoscopic surgery to open surgery. This trial has been registered in the UMIN Clinical Trials Registry as UMIN000017628.

  5. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

    PubMed Central

    Fenaux, Pierre; Mufti, Ghulam J; Hellstrom-Lindberg, Eva; Santini, Valeria; Finelli, Carlo; Giagounidis, Aristoteles; Schoch, Robert; Gattermann, Norbert; Sanz, Guillermo; List, Alan; Gore, Steven D; Seymour, John F; Bennett, John M; Byrd, John; Backstrom, Jay; Zimmerman, Linda; McKenzie, David; Beach, C L; Silverman, Lewis R

    2014-01-01

    Summary Background Drug treatments for patients with high-risk myelodysplastic syndromes provide no survival advantage. In this trial, we aimed to assess the effect of azacitidine on overall survival compared with the three commonest conventional care regimens. Methods In a phase III, international, multicentre, controlled, parallel-group, open-label trial, patients with higher-risk myelodysplastic syndromes were randomly assigned one-to-one to receive azacitidine (75 mg/m² per day for 7 days every 28 days) or conventional care (best supportive care, low-dose cytarabine, or intensive chemotherapy as selected by investigators before randomisation). Patients were stratified by French–American–British and international prognostic scoring system classifications; randomisation was done with a block size of four. The primary endpoint was overall survival. Efficacy analyses were by intention to treat for all patients assigned to receive treatment. This study is registered with ClinicalTrials.gov, number NCT00071799. Findings Between Feb 13, 2004, and Aug 7, 2006, 358 patients were randomly assigned to receive azacitidine (n=179) or conventional care regimens (n=179). Four patients in the azacitidine and 14 in the conventional care groups received no study drugs but were included in the intention-to-treat efficacy analysis. After a median follow-up of 21·1 months (IQR 15·1–26·9), median overall survival was 24·5 months (9·9–not reached) for the azacitidine group versus 15·0 months (5·6–24·1) for the conventional care group (hazard ratio 0·58; 95% CI 0·43–0·77; stratified log-rank p=0·0001). At last follow-up, 82 patients in the azacitidine group had died compared with 113 in the conventional care group. At 2 years, on the basis of Kaplan-Meier estimates, 50·8% (95% CI 42·1–58·8) of patients in the azacitidine group were alive compared with 26·2% (18·7–34·3) in the conventional care group (p<0·0001). Peripheral cytopenias were the most

  6. Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren's syndrome: an open-label phase I/II study

    PubMed Central

    Steinfeld, Serge D; Tant, Laure; Burmester, Gerd R; Teoh, Nick KW; Wegener, William A; Goldenberg, David M; Pradier, Olivier

    2006-01-01

    This open-label, phase I/II study investigated the safety and efficacy of epratuzumab, a humanised anti-CD22 monoclonal antibody, in the treatment of patients with active primary Sjögren's syndrome (pSS). Sixteen Caucasian patients (14 females/2 males, 33–72 years) were to receive 4 infusions of 360 mg/m2 epratuzumab once every 2 weeks, with 6 months of follow-up. A composite endpoint involving the Schirmer-I test, unstimulated whole salivary flow, fatigue, erythrocyte sedimentation rate (ESR), and immunoglobulin G (IgG) was devised to provide a clinically meaningful assessment of response, defined as a ≥20% improvement in at least two of the aforementioned parameters, with ≥20% reduction in ESR and/or IgG considered as a single combined criterion. Fourteen patients received all infusions without significant reactions, 1 patient received 3, and another was discontinued due to a mild acute reaction after receiving a partial infusion. Three patients showed moderately elevated levels of Human anti-human (epratuzumab) antibody not associated with clinical manifestations. B-cell levels had mean reductions of 54% and 39% at 6 and 18 weeks, respectively, but T-cell levels, immunoglobulins, and routine safety laboratory tests did not change significantly. Fifty-three percent achieved a clinical response (at ≥20% improvement level) at 6 weeks, with 53%, 47%, and 67% responding at 10, 18, and 32 weeks, respectively. Approximately 40%–50% responded at the ≥30% level, while 10%–45% responded at the ≥50% level for 10–32 weeks. Additionally, statistically significant improvements were observed in fatigue, and patient and physician global assessments. Further, we determined that pSS patients have a CD22 over-expression in their peripheral B cells, which was downregulated by epratuzumab for at least 12 weeks after the therapy. Thus, epratuzumab appears to be a promising therapy in active pSS, suggesting that further studies be conducted. PMID:16859536

  7. On the metallicity of open clusters. III. Homogenised sample

    NASA Astrophysics Data System (ADS)

    Netopil, M.; Paunzen, E.; Heiter, U.; Soubiran, C.

    2016-01-01

    Context. Open clusters are known as excellent tools for various topics in Galactic research. For example, they allow accurately tracing the chemical structure of the Galactic disc. However, the metallicity is known only for a rather low percentage of the open cluster population, and these values are based on a variety of methods and data. Therefore, a large and homogeneous sample is highly desirable. Aims: In the third part of our series we compile a large sample of homogenised open cluster metallicities using a wide variety of different sources. These data and a sample of Cepheids are used to investigate the radial metallicity gradient, age effects, and to test current models. Methods: We used photometric and spectroscopic data to derive cluster metallicities. The different sources were checked and tested for possible offsets and correlations. Results: In total, metallicities for 172 open cluster were derived. We used the spectroscopic data of 100 objects for a study of the radial metallicity distribution and the age-metallicity relation. We found a possible increase of metallicity with age, which, if confirmed, would provide observational evidence for radial migration. Although a statistical significance is given, more studies are certainly needed to exclude selection effects, for example. The comparison of open clusters and Cepheids with recent Galactic models agrees well in general. However, the models do not reproduce the flat gradient of the open clusters in the outer disc. Thus, the effect of radial migration is either underestimated in the models, or an additional mechanism is at work. Conclusions: Apart from the Cepheids, open clusters are the best tracers for metallicity over large Galactocentric distances in the Milky Way. For a sound statistical analysis, a sufficiently large and homogeneous sample of cluster metallicities is needed. Our compilation is currently by far the largest and provides the basis for several basic studies such as the statistical

  8. REORIENTATION--"THE OPEN BOAT." LITERATURE CURRICULUM III, STUDENT VERSION.

    ERIC Educational Resources Information Center

    CRANE, STEPHEN; KITZHABER, ALBERT R.

    A SHORT STORY, STEPHEN CRANE'S "THE OPEN BOAT," AND SUGGESTIONS FOR STUDY OF THE STORY WERE PRESENTED IN A STUDY GUIDE, ONE OF A SERIES OF CURRICULUM GUIDES PRODUCED FOR USE BY A NINTH-GRADE ENGLISH CLASS. ONE STUDY TECHNIQUE PRESENTED, CALLED "THE EXPLODED DIAGRAM," INVOLVED SEPARATING THE STORY'S CONTENT INTO SUCH SINGLE ELEMENTS AS SUBJECT,…

  9. [Results of open multicenter study of the safety of doxazosin in combination with indigal in men with stages I-II prostatic adenoma].

    PubMed

    Pavlov, V N; Komiakov, B K; Grigor'ev, M É; Sivkov, A V; Bliumberg, B I; Kazikhinoruv, A A; Izmaĭlov, A A; Boiarko, A V; Abzalilov, R A

    2013-01-01

    The article presents a method of conservative treatment of men with I-II stage prostatic adenoma using a combination of doxazosin and indigal, which has antioxidant, antiproliferative and anti-inflammatory properties, that allowed improving urodynamic parameters and reducing the progression prostate adenoma, minimizing the adverse effects of treatment.

  10. A qualitative study of recovery from type III-B and III-C tibial fractures.

    PubMed

    Shauver, Melissa S; Aravind, Maya S; Chung, Kevin C

    2011-01-01

    The literature has shown that long-term outcomes for both below-knee amputation and reconstruction after type III-B and III-C tibial fracture are poor. Yet, patients often report satisfaction with their treatment and outcomes. The aim of this study was to explore the relationship between patient outcomes and satisfaction after open tibial fractures via qualitative methodology. Twenty patients who were treated for open tibial fractures at one institution were selected using purposeful sampling and interviewed in-person in a semi-structured manner. Data were analyzed using grounded theory methodology. Despite reporting marked physical and psychosocial deficits, participants relayed high satisfaction. We hypothesize that the use of adaptive coping techniques successfully reduces stress, which leads to an increase in coping self-efficacy that results in the further use of adaptive coping strategies, culminating in personal growth. This stress reduction and personal growth leads to satisfaction despite poor functional and emotional outcomes.

  11. A phase 2, multicenter, open-label study of sepantronium bromide (YM155) plus docetaxel in patients with stage III (unresectable) or stage IV melanoma

    PubMed Central

    Kudchadkar, Ragini; Ernst, Scott; Chmielowski, Bartosz; Redman, Bruce G; Steinberg, Joyce; Keating, Anne; Jie, Fei; Chen, Caroline; Gonzalez, Rene; Weber, Jeffrey

    2015-01-01

    Survivin is a microtubule-associated protein believed to be involved in preserving cell viability and regulating tumor cell mitosis, and it is overexpressed in many primary tumor types, including melanoma. YM155 is a first-in-class survivin suppressant. The purpose of this Phase 2 study was to evaluate the 6-month progression-free survival (PFS) rate in patients with unresectable Stage III or IV melanoma receiving a combination of YM155 plus docetaxel. The study had two parts: Part 1 established the dose of docetaxel that was tolerable in combination with YM155, and Part 2 evaluated the tolerable docetaxel dose (75 mg/m2) in combination with YM155 (5 mg/m2 per day continuous infusion over 168 h every 3 weeks). The primary endpoint was 6-month PFS rate. Secondary endpoints were objective response rate (ORR), 1-year overall survival (OS) rate, time from first response to progression, clinical benefit rate (CBR), and safety. Sixty-four patients with metastatic melanoma were treated with docetaxel and YM155. Eight patients received an initial docetaxel dose of 100 mg/m2 and 56 patients received 75 mg/m2 of docetaxel. Six-month PFS rate per Independent Review Committee (IRC) was 34.8% (n = 64; 95% CI, 21.3–48.6%), and per Investigator was 31.3% (n = 64; 95% CI, 19.5–43.9%). The best ORR (complete response [CR] + partial response [PR]) per IRC was 12.5% (8/64). The stable disease (SD) rate was 51.6% (33/64), leading to a CBR (CR + PR + SD) of 64.1% (41/64). Estimated probability of 1-year survival was 56.3%. YM155 is a novel agent showing modest activity when combined with docetaxel for treating patients with melanoma. YM155 was generally well tolerated, but the predetermined primary efficacy endpoint (i.e., 6-month PFS rate ≥20%) was not achieved. PMID:25533314

  12. District Practices Study. Phase III Summary Report.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Reston, VA.

    Following up on the first two phases (1976-82) of the "District Practices Study" of Title I of the Elementary and Secondary Education Act (ESEA) as presented in a resource book and seven special reports, this report is devoted to the study's third and final phase. During phase III (1982-83), researchers visited 14 sites to describe their solutions…

  13. [Meaning of living with external fixation for grade III open fracture of lower limbs: patient view].

    PubMed

    Lopez, Catia Cristina Gomes; Gamba, Mônica Antar; Matheus, Maria Clara Cassuli

    2013-06-01

    The present study is aimed to understand the meaning of living with an external fixation device for grade III open fractures of the lower limbs from the perspective of the patient. The data were collected with six young adults who were undergoing outpatient orthopedic treatment in a public hospital in the city of São Paulo, through semi-structured interviews with open questions, between June and August 2010. Seeking to understand the meaning of this experience, we have maintained a phenomenological attitude during the analysis, which made it possible to reveal the phenomenon "try to live in spite of feeling trapped in a cage." Patients said that their personal desire and support from others helped them reorganize their lives, despite the several challenges they had to overcome to adapt to the fastener attached to their body and the fear of the future and doubts about the success of treatment.

  14. REORIENTATION--"THE OPEN BOAT." LITERATURE CURRICULUM III, TEACHER VERSION.

    ERIC Educational Resources Information Center

    CRANE, STEPHEN; KITZHABER, ALBERT R.

    IN THIS TEACHER'S GUIDE FOR NINTH-GRADE ENGLISH CLASSES, AN APPROACH TO THE ANALYSIS OF STEPHEN CRANE'S "THE OPEN BOAT" WAS OUTLINED. THE APPROACH EMPHASIZED DEVELOPMENT OF STUDENT UNDERSTANDING OF THE STORY'S SUBJECT, FORM, AND POINT-OF-VIEW. THIS APPROACH INCORPORATED THE PRINCIPLES OF ANALYSIS OF LITERATURE THAT WERE INTRODUCED IN THE OREGON…

  15. Structural and photophysical studies on ternary Sm(III), Nd(III), Yb(III), Er(III) complexes containing pyridyltriazole ligands

    PubMed Central

    Gusev, Alexey N.; Shul’gin, Victor F.; Meshkova, Svetlana B.; Hasegawa, Miki; Alexandrov, Grigory G.; Eremenko, Igor L.; Linert, Wolfgang

    2012-01-01

    Two bidentate pyridine-triazole ligands (3-(pyridine-2-yl)-5-phenyl-1,2,4-triazole (L1) and 5-phenyl-2-(2′-pyridyl)-7,8-benzo-6,5-dihydro-1,3,6-triazaindolizine (L2)), have been synthesized and used for Ln(Dbm)3 (Ln = Sm(III), Nd(III), Yb(III) and Er(III)) coordination. The structures of the ligands and resulting Sm(III) complex were determined in the solid state by X-ray diffraction. The title complexes were characterized by UV, fluorescent, IR-spectroscopy and thermogravimetric and elemental analyses. Photophysical studies on the Ln(III) complexes were carried out showing luminescence in the region typical for Ln(III). The effect of various factors on the enhancement luminescence of complexes is discussed. PMID:23470984

  16. Three cross leg flaps for lower leg reconstruction of Gustilo type III C open fracture

    PubMed Central

    Sano, Kazufumi; Ozeki, Satoru; Sugimoto, Ichiro; Ogawa, Masato

    2016-01-01

    A 60 year old male had Gustilo type III C open fracture of the right lower leg. After radical debridement, the large open defect including certain loss of the bone tissue was successfully augmented and covered, by consecutive three cross-leg flaps, which consisted of the free rectus abdominis musculocutaneous flap, the fibula osteocutaneous flap and the conventional sural flap. Although indication for amputation or preservation is decided with multiple factors in each case, a strategic combination of cross-leg flap, free flap, external fixation and vascular delay could increase the potential of preservation of the lower leg with even disastrous Gustilo type III C. PMID:27293297

  17. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter...

  18. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter...

  19. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter...

  20. Trapping Open and Closed Forms of FitE-A Group III Periplasmic Binding Protein

    SciTech Connect

    Shi, R.; Proteau, A; Wagner, J; Cui, Q; Purisima, E; Matte, A; Cygler, M

    2009-01-01

    Periplasmic binding proteins (PBPs) are essential components of bacterial transport systems, necessary for bacterial growth and survival. The two-domain structures of PBPs are topologically classified into three groups based on the number of crossovers or hinges between the globular domains: group I PBPs have three connections, group II have two, and group III have only one. Although a large number of structures for group I or II PBPs are known, fewer group III PBPs have been structurally characterized. Group I and II PBPs exhibit significant domain motions during transition from the unbound to ligand-bound form, however, no large conformational changes have been observed to date in group III PBPs. We have solved the crystal structure of a periplasmic binding protein FitE, part of an iron transport system, fit, recently identified in a clinical E. coli isolate. The structure, determined at 1.8 {angstrom} resolution, shows that FitE is a group III PBP containing a single {alpha}-helix bridging the two domains. Among the individual FitE molecules present in two crystal forms we observed three different conformations (open, closed, intermediate). Our crystallographic and molecular dynamics results strongly support the notion that group III PBPs also adopt the same Venus flytrap mechanism as do groups I and II PBPs. Unlike other group III PBPs, FitE forms dimers both in solution and in the crystals. The putative siderophore binding pocket is lined with arginine residues, suggesting an anionic nature of the iron-containing siderophore.

  1. Experimental and Theoretical Studies on Biologically Active Lanthanide (III) Complexes

    NASA Astrophysics Data System (ADS)

    Kostova, I.; Trendafilova, N.; Georgieva, I.; Rastogi, V. K.; Kiefer, W.

    2008-11-01

    The complexation ability and the binding mode of the ligand coumarin-3-carboxylic acid (HCCA) to La(III), Ce(III), Nd(III), Sm(III), Gd(III) and Dy(III) lanthanide ions (Ln(III)) are elucidated at experimental and theoretical level. The complexes were characterized using elemental analysis, DTA and TGA data as well as 1H NMR and 13C NMR spectra. FTIR and Raman spectroscopic techniques as well as DFT quantum chemical calculations were used for characterization of the binding mode and the structures of lanthanide(III) complexes of HCCA. The metal—ligand binding mode is predicted through molecular modeling and energy estimation of different Ln—CCA structures using B3LYP/6-31G(d) method combined with a large quasi-relativistic effective core potential for lanthanide ion. The energies obtained predict bidentate coordination of CCA- to Ln(III) ions through the carbonylic oxygen and the carboxylic oxygen. Detailed vibrational analysis of HCCA, CCA- and Ln(III) complexes based on both calculated and experimental frequencies confirms the suggested metal—ligand binding mode. The natural bonding analysis predicts strongly ionic character of the Ln(III)-CCA bonding in the- complexes studied. With the relatively resistant tumor cell line K-562 we obtained very interesting in-vitro results which are in accordance with our previously published data concerning the activity of lanthanide(III) complexes with other coumarin derivatives.

  2. Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial)

    PubMed Central

    Aoyagi, Reiko; Hamada, Hiromichi; Sato, Yasunori; Suzuki, Hiroyuki; Onouchi, Yoshihiro; Ebata, Ryota; Terauchi, Moe; Terai, Masaru; Hanaoka, Hideki; Hata, Akira

    2015-01-01

    Introduction Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown aetiology that predominantly affects infants and young children. We hypothesise that cyclosporin A (CsA) may be effective in treating KD by regulating the Ca2+/NFAT signalling pathway. This trial compares the current standard therapy of intravenous immunoglobulin (IVIG) and the combined IVIG+CsA therapy in paediatric patients with severe KD. Methods and analysis This trial is a phase III, multicentre, randomised, open-label, blinded-end point trial that evaluates the efficacy and safety of IVIG+CsA therapy. Patients with severe KD who satisfy the eligibility criteria are randomised (1:1) to receive either CsA (5 mg/kg/day for 5 days; Neoral) plus high-dose IVIG (2 g/kg for 24 h and aspirin 30 mg/kg/day), or high-dose IVIG alone (2 g/kg for 24 h and aspirin 30 mg/kg/day). The primary end point is the frequency of occurrence of coronary artery abnormalities during the trial period. An independent end point review committee will be in charge of the trial assessment. Ethics and dissemination The protocol was approved by the Institutional Review Board of each institution. The trial was notified and registered at the Pharmaceutical and Medical Devices Agency, in Japan. The trial is currently on-going and is scheduled to finish in April 2017. The findings will be disseminated through peer-reviewed publications and conference presentations. Trial registration number JMA-IIA00174; Pre-results. PMID:26628527

  3. A XAFS study of plain and composite iron(III) and chromium(III) hydroxides.

    PubMed

    Papassiopi, N; Pinakidou, F; Katsikini, M; Antipas, G S E; Christou, C; Xenidis, A; Paloura, E C

    2014-09-01

    Reduction of hexavalent Cr(VI) to the trivalent state is the common strategy for remediation of Cr(VI) contaminated waters and soils. In the presence of Fe the resulting compounds are usually mixed Fe(III)-Cr(III) phases, while, under iron-free conditions, reduction leads to formation of plain Cr(III) hydroxides. Environmental stability of these compounds depends on their structure and is important to understand how different precipitation conditions affect the local atomic order of resulting compounds and thus their long term stability. In current study, typical Cr(VI) environmental remediation products, i.e. plain and mixed Fe(III)-Cr(III) hydroxides, were synthesized by hydrolysis and redox reactions and their structure was studied by X ray diffraction and X ray absorption fine structure techniques. Plain Cr(III) hydroxide was found to correspond to the molecular formula Cr(OH)3·3H2O and was identified as crystalline in XRD. However, the same compound when examined by EXAFS did not exhibit any clear local order in the range of EXAFS detectable distances, i.e. between 0 and 5Å. Namely, EXAFS spectroscopy detected only contribution from the first nearest neighboring (Cr-O) shell, suggesting that CrO6 octahedra interconnection is loose, in accordance with the suggested anti-bayerite structure of this compound. Mixed Fe(III)-Cr(III) systems resembled 2-line ferrihydrite irrespective of the synthesis route. Analysis of Fe-K-EXAFS and Cr-K-EXAFS spectra indicated that FeO6 octahedra are bonded by sharing both edges and corners, while CrO6 octahedra seem to prefer edge sharing linkage. EXAFS data also suggest that Fe-Cr hydroxide produced by hydrolysis presents a better arrangement of CrO6 octahedra compared to the redox product.

  4. Trapping open and closed forms of FitE: a group III periplasmic binding protein.

    PubMed

    Shi, Rong; Proteau, Ariane; Wagner, John; Cui, Qizhi; Purisima, Enrico O; Matte, Allan; Cygler, Miroslaw

    2009-05-15

    Periplasmic binding proteins (PBPs) are essential components of bacterial transport systems, necessary for bacterial growth and survival. The two-domain structures of PBPs are topologically classified into three groups based on the number of crossovers or hinges between the globular domains: group I PBPs have three connections, group II have two, and group III have only one. Although a large number of structures for group I or II PBPs are known, fewer group III PBPs have been structurally characterized. Group I and II PBPs exhibit significant domain motions during transition from the unbound to ligand-bound form, however, no large conformational changes have been observed to date in group III PBPs. We have solved the crystal structure of a periplasmic binding protein FitE, part of an iron transport system, fit, recently identified in a clinical E. coli isolate. The structure, determined at 1.8 A resolution, shows that FitE is a group III PBP containing a single alpha-helix bridging the two domains. Among the individual FitE molecules present in two crystal forms we observed three different conformations (open, closed, intermediate). Our crystallographic and molecular dynamics results strongly support the notion that group III PBPs also adopt the same Venus flytrap mechanism as do groups I and II PBPs. Unlike other group III PBPs, FitE forms dimers both in solution and in the crystals. The putative siderophore binding pocket is lined with arginine residues, suggesting an anionic nature of the iron-containing siderophore. PMID:19004000

  5. Quantum chemical study of arsenic (III, V) adsorption on Mn-oxides: implications for arsenic(III) oxidation.

    PubMed

    Zhu, Mengqiang; Paul, Kristian W; Kubicki, James D; Sparks, Donald L

    2009-09-01

    Density functional theory (DFT) calculations were used to investigate As(V) and As(III) surface complex structures and reaction energies on both Mn(III) and Mn(IV) sites in an attempt to better understand As(III) oxidation bybirnessite, a layered Mn-dioxide mineral. Edge-sharing dioctahedral Mn(III) and Mn(IV) clusters with different combinations of surface functional groups (>MnOH and >MnOH2) were employed to mimic pH variability. Results show that As(V) adsorption was more thermodynamically favorable than As(III) adsorption on both Mn(III) and Mn(IV) surface sites under simulated acidic pH conditions. Therefore, we propose that As(V) adsorption inhibits As(III) oxidation by blocking adsorption sites. Under simulated acidic pH conditions, Mn(IV) sites exhibited stronger adsorption affinity than Mn(III) sites for both As(III) and As(V). Overall, we hypothesize that Mn(III) sites are less reactive in terms of As(III) oxidation due to their lower affinity for As(III) adsorption, higher potential to be blocked by As(V) complexes, and slower electron transfer rates with adsorbed As(III). Results from this study offer an explanation regarding the experimental observations of Mn(III) accumulation on birnessite and the long residence time of As(III) adsorption complexes on manganite (r-MnOOH) during As(III) oxidation. PMID:19764231

  6. Nonsurgical treatment of adult open bite using edgewise appliance combined with high-pull headgear and class III elastics.

    PubMed

    Saito, Isao; Yamaki, Masaki; Hanada, Kooji

    2005-03-01

    This case report describes the effect of a combination of high-pull headgear and Class III elastics on the nonsurgical treatment of an adult open bite. The 19-year 1-month-old Japanese female presented with the anterior open bite of 4.0 mm and mild crowding. She had a skeletal Class II but a Class III molar relationship due to a severe proclination of the mandibular dental arch. Unilateral congenital missing premolars caused a discrepancy between the facial and dental midline. After extraction of two premolars and the impacted mandibular third molars, nonsurgical therapy was performed using the standard edgewise appliance combined with a high-pull headgear and Class III elastics. The successful treatment outcome and stability of the final occlusion indicates that a combination of high-pull headgear and Class III elastics is one of the effective devices in the nonsurgical treatment of open bite and, is especially helpful in uprighting the mandibular dental arch.

  7. Management of an Adult with Spaced Dentition, Class III Malocclusion and Open-bite Tendency

    PubMed Central

    Kaya, Demet; Taner, Tulin Ugur

    2011-01-01

    The aim of this case report was to present the orthodontic treatment of an adult with spaced dentition, Class III malocclusion, and open-bite tendency. A 28.4-year-old adult woman was concerned about the unesthetic appearance of her spaced dentition localized at both upper and lower arches while smiling. She had a mild tongue thrust, hypertropic upper frenum, and mild speech difficulty while pronouncing “s”. Her profile was straight with prominent lips. Molar relationship was Class III on both sides. Anterior teeth were in an end-to-end relationship. Lower dental midline was deviated to the left side. Cephalometric analysis revealed a skeletal Class III relationship with hyperdivergent facial pattern. The treatment plan included myotherapeutic exercises for the tongue thrust habit and a diagnostic set-up for closure of diastemas. A strict retention protocol was followed combined with gingivoplasty, fiberotomy, and frenectomy procedures. All spaces were closed successfully, adequate overbite and overjet relationships were obtained, and tongue thrust habit and speech difficulty while pronouncing “s” were eliminated. Clinical and cephalometric results indicated the maintenance of the treatment outcome at 6-months post-retention period. PMID:21228963

  8. [The research protocol III. Study population].

    PubMed

    Arias-Gómez, Jesús; Villasís-Keever, Miguel Ángel; Miranda-Novales, María Guadalupe

    2016-01-01

    The study population is defined as a set of cases, determined, limited, and accessible, that will constitute the subjects for the selection of the sample, and must fulfill several characteristics and distinct criteria. The objectives of this manuscript are focused on specifying each one of the elements required to make the selection of the participants of a research project, during the elaboration of the protocol, including the concepts of study population, sample, selection criteria and sampling methods. After delineating the study population, the researcher must specify the criteria that each participant has to comply. The criteria that include the specific characteristics are denominated selection or eligibility criteria. These criteria are inclusion, exclusion and elimination, and will delineate the eligible population. The sampling methods are divided in two large groups: 1) probabilistic or random sampling and 2) non-probabilistic sampling. The difference lies in the employment of statistical methods to select the subjects. In every research, it is necessary to establish at the beginning the specific number of participants to be included to achieve the objectives of the study. This number is the sample size, and can be calculated or estimated with mathematical formulas and statistic software. PMID:27174763

  9. Interdisciplinary Studies Program. Teacher's Guide: Part III.

    ERIC Educational Resources Information Center

    Valencia Community Coll., Orlando, FL.

    This teacher's guide was developed for the third of four courses in Valencia Community College's Interdisciplinary Studies program, a 2-year core general education curriculum which chronologically examines the major developments in the evolution of human knowledge. The guide provides an introductory overview of the course's topic (i.e., Western…

  10. [The research protocol III. Study population].

    PubMed

    Arias-Gómez, Jesús; Villasís-Keever, Miguel Ángel; Miranda-Novales, María Guadalupe

    2016-01-01

    The study population is defined as a set of cases, determined, limited, and accessible, that will constitute the subjects for the selection of the sample, and must fulfill several characteristics and distinct criteria. The objectives of this manuscript are focused on specifying each one of the elements required to make the selection of the participants of a research project, during the elaboration of the protocol, including the concepts of study population, sample, selection criteria and sampling methods. After delineating the study population, the researcher must specify the criteria that each participant has to comply. The criteria that include the specific characteristics are denominated selection or eligibility criteria. These criteria are inclusion, exclusion and elimination, and will delineate the eligible population. The sampling methods are divided in two large groups: 1) probabilistic or random sampling and 2) non-probabilistic sampling. The difference lies in the employment of statistical methods to select the subjects. In every research, it is necessary to establish at the beginning the specific number of participants to be included to achieve the objectives of the study. This number is the sample size, and can be calculated or estimated with mathematical formulas and statistic software.

  11. Studies on methanol - oxidizing yeast. III. Enzyme.

    PubMed

    Volfová, O

    1975-01-01

    Oxidation of methanol, formaldehyde and formic acid was studied in cells and cell-free extract of the yeast Candida boidinii No. 11Bh. Methanol oxidase, an enzyme oxidizing methanol to formaldehyde, was formed inducibly after the addition of methanol to yeast cells. The oxidation of methanol by cell-free extract was dependent on the presence of oxygen and independent of any addition of nicotine-amide nucleotides. Temperature optimum for the oxidation of methanol to formaldehyde was 35 degrees C, pH optimum was 8.5. The Km for methanol was 0.8mM. The cell-free extract exhibited a broad substrate specificity towards primary alcohols (C1--C6). The activity of methanol oxidase was not inhibited by 1mM KCN, EDTA or monoiodoacetic acid. The strongest inhibitory action was exerted by p-chloromercuribenzoate. Both the cells and the cell-free extract contained catalase which participated in the oxidation of methanol to formaldehyde; the enzyme was constitutively formed by the yeast. The pH optimum for the degradation of H2O2 was in the same range as the optimum for methanol oxidation, viz. at 8.5. Catalase was more resistant to high pH than methanol oxidase. The cell-free extract contained also GSH-dependent NAD-formaldehyde dehydrogenase with Km = 0.29mM and NAD-formate dehydrogenase with Km = 55mM. PMID:240764

  12. Formylated chloro-bridged iridium(III) dimers as OLED materials: opening up new possibilities.

    PubMed

    Wong, Michael Y; Xie, Guohua; Tourbillon, Clarisse; Sandroni, Martina; Cordes, David B; Slawin, Alexandra M Z; Samuel, Ifor D W; Zysman-Colman, Eli

    2015-05-14

    In this study, a series of four formyl-substituted chloro-bridged iridium(iii) dimers were prepared. Their absorption, photophysical and electrochemical properties were studied in dichloromethane solution. It was found that as the formyl content increased on the cyclometalating ligands, emission unexpectedly became brighter. Organic light-emitting diodes (OLEDs) were fabricated using each of these iridium dimers as the emitter. The OLED fabricated using the brightest of the series, 2b, as the dopant afforded a decent external quantum efficiency (EQE) of 2.6%. This suggests that chloro-bridged iridium dimers are potential candidates as solid-state emitters.

  13. Nursing III. A Course of Study. Health Occupations Education.

    ERIC Educational Resources Information Center

    Rogers, Helen V.

    This curriculum guide for instructors provides a course of study (Nursing III) requisite for the third and concluding portion of a 1-year practical nursing curriculum designed to continue opportunities for career mobility in the health occupations. Content is in three sections: (1) Medical Surgical Nursing II, (2) Mental Health Nursing, and (3)…

  14. Selective Extraction of Americium(III) over Europium(III) with the Pyridylpyrazole Based Tetradentate Ligands: Experimental and Theoretical Study.

    PubMed

    Wang, Jieru; Su, Dongping; Wang, Dongqi; Ding, Songdong; Huang, Chao; Huang, Huang; Hu, Xiaoyang; Wang, Zhipeng; Li, Shimeng

    2015-11-16

    1,3-Bis[3-(2-pyridyl)pyrazol-1-yl]propane (Bippp) and 1,2-bis[3-(2-pyridyl)pyrazyl-1-methyl]benzene (Dbnpp), the pyridylpyrazole based tetradentate ligands, were synthesized and characterized by MS, NMR, and FT-IR. The solvent extraction and complexation behaviors of Am(III) and Eu(III) with the ligands were investigated experimentally and theoretically. In the presence of 2-bromohexanoic acid, the two ligands can effectively extract Am(III) over Eu(III) and other rare earth(III) metals (RE(III)) in HNO3 solution with the separation factors (SFAm/RE) ranging from 15 to 60. Slope analyses showed that both Am(III) and Eu(III) were extracted as monosolvated species, which agrees well with the results observed from X-ray crystallography and MS analyses. The stability constants (log K) obtained from UV-vis titration for Eu(III) complexes with Bippp and Dbnpp are 4.75 ± 0.03 and 4.45 ± 0.04, respectively. Both UV-vis titration and solvent extraction studies indicated that Bippp had stronger affinity for Eu(III) than Dbnpp, which is confirmed by density functional theory (DFT) calculations. DFT calculations revealed that the AmL(NO3)3 (L = Bippp and Dbnpp) complexes are thermodynamically more stable in water than their Eu(III) analogues, which is caused by greater covalency of the Am-N than Eu-N bonds. Theoretical studies gave an insight into the nature of the M(III)-ligand bonding interactions. PMID:26517736

  15. 1,2,4-Diazaphospholide complexes of lanthanum(iii), cerium(iii), neodymium(iii), praseodymium(iii), and samarium(iii): synthesis, X-ray structural characterization, and magnetic susceptibility studies.

    PubMed

    Zhao, Minggang; Wang, Lixia; Li, Pangpang; Ma, Jianping; Zheng, Wenjun

    2016-07-01

    A few heteroleptic, charge-separated heterobimetallic, and polymeric alkali metalate complexes of 1,2,4-diazaphospholide lanthanum(iii), cerium(iii), neodymium(iii), praseodymium(iii), and samarium(iii) were simply prepared via the metathesis reaction of MCl3 (THF)m (m = 1-2) and K[3,5-R2dp] ([3,5-R2dp](-) = 3,5-di-substituent-1,2,4-diazaphospholide; R = tBu, Ph) in a varied ratio (1 : 3, 1 : 4, and 1 : 5, respectively) at room temperature in tetrahydrofuran. All the complexes were fully characterized by (1)H, (13)C{(1)H}, (31)P{(1)H}, IR, and X-ray single crystal diffraction analysis despite their paramagnetism (excluding La(iii) complexes). The structures of the complexes were found to feature varied coordination modes. The magnetic properties of several compounds were studied by magnetic susceptibility, and the complexes presented the magnetic moments close to or lower than the theoretical values for the free ions in the trivalent oxidation states (Pr(3+), Nd(3+)). PMID:27326667

  16. 1,2,4-Diazaphospholide complexes of lanthanum(iii), cerium(iii), neodymium(iii), praseodymium(iii), and samarium(iii): synthesis, X-ray structural characterization, and magnetic susceptibility studies.

    PubMed

    Zhao, Minggang; Wang, Lixia; Li, Pangpang; Ma, Jianping; Zheng, Wenjun

    2016-07-01

    A few heteroleptic, charge-separated heterobimetallic, and polymeric alkali metalate complexes of 1,2,4-diazaphospholide lanthanum(iii), cerium(iii), neodymium(iii), praseodymium(iii), and samarium(iii) were simply prepared via the metathesis reaction of MCl3 (THF)m (m = 1-2) and K[3,5-R2dp] ([3,5-R2dp](-) = 3,5-di-substituent-1,2,4-diazaphospholide; R = tBu, Ph) in a varied ratio (1 : 3, 1 : 4, and 1 : 5, respectively) at room temperature in tetrahydrofuran. All the complexes were fully characterized by (1)H, (13)C{(1)H}, (31)P{(1)H}, IR, and X-ray single crystal diffraction analysis despite their paramagnetism (excluding La(iii) complexes). The structures of the complexes were found to feature varied coordination modes. The magnetic properties of several compounds were studied by magnetic susceptibility, and the complexes presented the magnetic moments close to or lower than the theoretical values for the free ions in the trivalent oxidation states (Pr(3+), Nd(3+)).

  17. Synthesis of Imine-Naphthol Tripodal Ligand and Study of Its Coordination Behaviour towards Fe(III), Al(III), and Cr(III) Metal Ions

    PubMed Central

    Kaur, Kirandeep

    2014-01-01

    A hexadentate Schiff base tripodal ligand is synthesized by the condensation of tris (2-aminoethyl) amine with 2-hydroxy-1-naphthaldehyde and characterized by various spectroscopic techniques like UV-VIS, IR, NMR, MASS, and elemental analysis. The solution studies by potentiometric and spectrophotometric methods are done at 25 ± 1°C, µ = 0.1 M KCl, to calculate the protonation constants of the ligand and formation constants of metal complexes formed by the ligand with Fe(III), Al(III), and Cr(III) metal ions. The affinity of the ligand towards Fe(III) is compared with deferiprone (a drug applied for iron intoxication) and transferrin (the main Fe(III) binding protein in plasma). Structural analysis of the ligand and the metal complexes was done using semiempirical PM6 method. Electronic and IR spectra are calculated by semiempirical methods and compared with experimental one. PMID:25294978

  18. Synthesis of Imine-Naphthol Tripodal Ligand and Study of Its Coordination Behaviour towards Fe(III), Al(III), and Cr(III) Metal Ions.

    PubMed

    Kaur, Kirandeep; Baral, Minati

    2014-01-01

    A hexadentate Schiff base tripodal ligand is synthesized by the condensation of tris (2-aminoethyl) amine with 2-hydroxy-1-naphthaldehyde and characterized by various spectroscopic techniques like UV-VIS, IR, NMR, MASS, and elemental analysis. The solution studies by potentiometric and spectrophotometric methods are done at 25 ± 1°C, µ = 0.1 M KCl, to calculate the protonation constants of the ligand and formation constants of metal complexes formed by the ligand with Fe(III), Al(III), and Cr(III) metal ions. The affinity of the ligand towards Fe(III) is compared with deferiprone (a drug applied for iron intoxication) and transferrin (the main Fe(III) binding protein in plasma). Structural analysis of the ligand and the metal complexes was done using semiempirical PM6 method. Electronic and IR spectra are calculated by semiempirical methods and compared with experimental one. PMID:25294978

  19. Synthesis of Imine-Naphthol Tripodal Ligand and Study of Its Coordination Behaviour towards Fe(III), Al(III), and Cr(III) Metal Ions.

    PubMed

    Kaur, Kirandeep; Baral, Minati

    2014-01-01

    A hexadentate Schiff base tripodal ligand is synthesized by the condensation of tris (2-aminoethyl) amine with 2-hydroxy-1-naphthaldehyde and characterized by various spectroscopic techniques like UV-VIS, IR, NMR, MASS, and elemental analysis. The solution studies by potentiometric and spectrophotometric methods are done at 25 ± 1°C, µ = 0.1 M KCl, to calculate the protonation constants of the ligand and formation constants of metal complexes formed by the ligand with Fe(III), Al(III), and Cr(III) metal ions. The affinity of the ligand towards Fe(III) is compared with deferiprone (a drug applied for iron intoxication) and transferrin (the main Fe(III) binding protein in plasma). Structural analysis of the ligand and the metal complexes was done using semiempirical PM6 method. Electronic and IR spectra are calculated by semiempirical methods and compared with experimental one.

  20. False lumens in type III aortic dissections: progress CT study

    SciTech Connect

    Yamaguchi, T.; Naito, H.; Ohta, M.; Sugahara, T.; Takamiya, M.; Kozuka, T.; Nakajima, N.

    1985-09-01

    The fate of false lumens in 13 patients having Type III aortic dissections was studied using computed tomography (CT). Contrast media filled false lumens with or without thrombosis were observed in ten patients; the false lumens of three patients were entirely thrombosed at initial examination. Follow-up CT studies showed shrinkage or disappearance of the false lumens with thrombosis in four patients, progression of thrombosis in two patients, and enlargement of the false lumen in one patient who subsequently required surgical repair. No change was observed in the remaining six patients during our observation period. CT study provides useful information for evaluating the efficacy of medical treatment and the timing of surgical intervention during follow-up evaluation of medically treated Type III aortic dissections.

  1. False lumens in type III aortic dissections: progress CT study.

    PubMed

    Yamaguchi, T; Naito, H; Ohta, M; Sugahara, T; Takamiya, M; Kozuka, T; Nakajima, N

    1985-09-01

    The fate of false lumens in 13 patients having Type III aortic dissections was studied using computed tomography (CT). Contrast media filled false lumens with or without thrombosis were observed in ten patients; the false lumens of three patients were entirely thrombosed at initial examination. Follow-up CT studies showed shrinkage or disappearance of the false lumens with thrombosis in four patients, progression of thrombosis in two patients, and enlargement of the false lumen in one patient who subsequently required surgical repair. No change was observed in the remaining six patients during our observation period. CT study provides useful information for evaluating the efficacy of medical treatment and the timing of surgical intervention during follow-up evaluation of medically treated Type III aortic dissections.

  2. Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates.

    PubMed

    Refat, Moamen S; Al-Azab, Fathi M; Al-Maydama, Hussein M A; Amin, Ragab R; Jamil, Yasmin M S; Kobeasy, Mohamed I

    2015-05-01

    Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E(∗), ΔH(∗), ΔS(∗) and ΔG(∗) were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi.

  3. Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Al-Azab, Fathi M.; Al-Maydama, Hussein M. A.; Amin, Ragab R.; Jamil, Yasmin M. S.; Kobeasy, Mohamed I.

    2015-05-01

    Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E∗, ΔH∗, ΔS∗ and ΔG∗ were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi.

  4. Synthesis, characterization, molecular docking and DNA binding studies of Al(III), Ga(III) and In(III) water-soluble complexes

    NASA Astrophysics Data System (ADS)

    Shorkaei, Mohammad Ranjkesh; Asadi, Zahra; Asadi, Mozaffar

    2016-04-01

    In this work three new water-soluble aluminum(III), gallium(III) and indium(III) Schiff base complexes; Na2[M(L)NO3]; where L denotes; N,N'-bis(5-sulfosalicyliden)-1,2-phenylendiamin (salsophen) were synthesized and characterized by UV-vis, 1HNMR, FT-IR spectroscopy, thermal gravimetry (TG) and elemental analysis. To study the biological preference with the molecular target DNA, interaction of these complexes with DNA have been explored by employing various biophysical methods including absorption spectra, fluorescence spectra, cyclic voltammetry and viscosity measurement. The Kb values at 298 K were found to be 1.17 × 104 for Al(III), 1.35 × 104 for Ga(III) and 1.64 × 104 M-1 for In(III) complexes, respectively. These results suggesting the greater binding propensity of In(III) complexes. Additionally molecular docking was carried out to ascertain the mode of action towards the molecular target DNA.

  5. Hexaammine Complexes of Cr(III) and Co(III): A Spectral Study.

    ERIC Educational Resources Information Center

    Brown, D. R.; Pavlis, R. R.

    1985-01-01

    Procedures are provided for experiments containing complex ions with octahedral symmetry, hexaamminecobalt(III) chloride and hexaamminechromium(III) nitrate, so students can interpret fully the ultra violet/visible spectra of the complex cations in terms of the ligand field parameters, 10 "Dq," the Racah interelectron repulsion parameters, "B,"…

  6. Safety and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTPa-IPV/Hib) vaccine in healthy Vietnamese toddlers: An open-label, phase III study.

    PubMed

    Anh, Dang Duc; Van Der Meeren, Olivier; Karkada, Naveen; Assudani, Deepak; Yu, Ta-Wen; Han, Htay Htay

    2016-03-01

    The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated polio (DTPa-IPV)/Hib vaccine when administered as a booster dose in 300 healthy Vietnamese children <2 years of age (mean age: 15.8 months). During the 4-day follow-up period, pain (31.7%) and redness (27.3%) were the most frequent solicited local symptoms. Pain (2%) was also the most frequent grade 3 local symptom. One subject reported 2 serious adverse events that were not causally related to the study vaccine. DTPa-IPV/Hib conjugate vaccine was well tolerated as a booster dose in healthy Vietnamese children aged <2 years.

  7. Safety and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTPa-IPV/Hib) vaccine in healthy Vietnamese toddlers: An open-label, phase III study

    PubMed Central

    Anh, Dang Duc; Van Der Meeren, Olivier; Karkada, Naveen; Assudani, Deepak; Yu, Ta-Wen; Han, Htay Htay

    2016-01-01

    abstract The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated polio (DTPa-IPV)/Hib vaccine when administered as a booster dose in 300 healthy Vietnamese children <2 years of age (mean age: 15.8 months). During the 4-day follow-up period, pain (31.7%) and redness (27.3%) were the most frequent solicited local symptoms. Pain (2%) was also the most frequent grade 3 local symptom. One subject reported 2 serious adverse events that were not causally related to the study vaccine. DTPa-IPV/Hib conjugate vaccine was well tolerated as a booster dose in healthy Vietnamese children aged <2 years. PMID:26337197

  8. Mark III Space Suit Mobility: A Reach Evaluation Case Study

    NASA Technical Reports Server (NTRS)

    Thaxton, Sherry S.; Abercromby, Andrew F. J.; Onady, Elizabeth A.; Rajulu, Sudhakar L.

    2007-01-01

    A preliminary assessment of the reach envelope and field of vision (FOV) for a subject wearing a Mark III space suit was requested for use in human-machine interface design of the Science Crew Operations and Utility Testbed (SCOUT) vehicle. The reach and view of two suited and unsuited subjects were evaluated while seated in the vehicle using 3-dimensional position data collected during a series of reaching motions. Data was interpolated and displayed in orthogonal views and cross-sections. Compared with unsuited conditions, medio-lateral reach was not strongly affected by the Mark III suit, whereas vertical and antero-posterior reach were inhibited by the suit. Lateral FOV was reduced by approximately 40 deg. in the suit. The techniques used in this case study may prove useful in human-machine interface design by providing a new means of developing and displaying reach envelopes.

  9. Opening the Ralstonia solanacearum type III effector tool box: insights into host cell subversion mechanisms.

    PubMed

    Deslandes, Laurent; Genin, Stephane

    2014-08-01

    Effectors delivered to host cells by the Type III secretion system are essential to Ralstonia solanacearum pathogenicity, as in several other plant pathogenic bacteria. The establishment of exhaustive effector repertoires in multiple R. solanacearum strains drew a first picture of the evolutionary dynamics of the pathogen effector suites. Effector repertoires are diversified, with a core of 20-30 effectors present in most of the strains and the obtention of mutants lacking one or more effector genes revealed the functional overlap among this effector network. Recent functional studies have provided insights into the ability of single effectors to manipulate the host proteasome, elicit cell death, trigger the expression of plant genes, and/or display biochemical activities on plant protein targets.

  10. Efficacy and safety profile of combination of tramadol-diclofenac versus tramadol-paracetamol in patients with acute musculoskeletal conditions, postoperative pain, and acute flare of osteoarthritis and rheumatoid arthritis: a Phase III, 5-day open-label study

    PubMed Central

    Chandanwale, Ajay S; Sundar, Subramanian; Latchoumibady, Kaliaperumal; Biswas, Swati; Gabhane, Mukesh; Naik, Manoj; Patel, Kamlesh

    2014-01-01

    Objective We aimed to evaluate the safety and efficacy of a fixed-dose combination (FDC) of tramadol and diclofenac versus a standard approved FDC of tramadol and paracetamol, in patients with acute moderate to severe pain. Methods A total of 204 patients with moderate to severe pain due to acute musculoskeletal conditions (n=52), acute flare of osteoarthritis (n=52), acute flare of rheumatoid arthritis (n=50), or postoperative pain (n=50) were enrolled in the study at baseline. Each disease category was then randomized to receive either of two treatments for 5 days: group A received an FDC of immediate-release tramadol hydrochloride (50 mg) and sustained-release diclofenac sodium (75 mg) (one tablet, twice daily), and group B received an FDC of tramadol hydrochloride (37.5 mg) and paracetamol (325 mg) (two tablets every 4–6 hours, up to a maximum of eight tablets daily). The primary efficacy end points were reductions in pain intensity from baseline at day 3 and day 5 as assessed by a Visual Analog Scale (VAS) score. Results Group A showed a significant reduction in the VAS score for overall pain from baseline on day 3 (P=0.001) and day 5 (P<0.0001) as compared with group B. The combination of tramadol-diclofenac resulted in few mild to moderate adverse events (nausea, vomiting, epigastric pain, and gastritis), which required minimal management, without any treatment discontinuation. The number of adverse events in group A was nine (8.82%) compared with 22 (21.78%) in group B, after 5 days of treatment. Conclusion An FDC of tramadol-diclofenac showed a significantly greater reduction in pain intensity and was well tolerated compared with tramadol-paracetamol, resulting in better analgesia in patients suffering from moderate to severe pain due to acute musculoskeletal conditions, postoperative pain following orthopedic surgery, or acute flare of osteoarthritis and rheumatoid arthritis. PMID:25152629

  11. a Mossbauer Effect Study of Iron(iii) Dithiocarbamates.

    NASA Astrophysics Data System (ADS)

    Fiddy, Judith Mary

    Available from UMI in association with The British Library. Ever since the pioneering work of Cambi iron(III) trisdithiocarbamates, which have the formula Fe(R _2NCS_2]_3 where R is an alkyl or an aryl group, have formed the basis for understanding spin-state equilibria in iron(III) complexes. Magnetic and infrared studies clearly indicate equilibrium between the high-spin and low-spin states. The Mossbauer spectra, however, show only a single component, indicating rapid relaxation between the two spin states on the Mossbauer timescale. It has been assumed that the spectral parameters are therefore a function of the relative spin-state populations. In this thesis, the results of Mossbauer experiments carried out on a series of iron(III) trisdithiocarbamates with various organic substituents, known to give a range of high-spin and low-spin state populations at room temperature, are presented. An iron(III) bisdithiocarbamate complex, Fe^{57} ((C_5 H_{10})_2NCS _2]_2NCS, was also investigated. The samples were studied at temperatures from 1.3K to 295K, and at pressures between atmospheric pressure and 80kbar at room temperature only. It was found that, in fact, the spin-equilibrium plays only a minor role in determining the Mossbauer spectra of the trisdithiocarbamate compounds. The effects of spin -state relaxation on the temperature dependence of the spectra are, in general, masked by those of slow paramagnetic relaxation which, in contrast to the effects of the spin-equilibrium, are marked and different for each compound. By fitting the spectra to models of paramagnetic relaxation the temperature dependence of the relaxation rates and possible directions of the magnetic hyperfine field relative to the major axis of the electric field gradient were found. The pressure dependence of the spectra was found to be rather similar for all the compounds, the main differences being in the widths and in the asymmetry of the areas of the spectral lines. Both these effects can

  12. VizieR Online Data Catalog: On the metallicity of open clusters. III. (Netopil+, 2016)

    NASA Astrophysics Data System (ADS)

    Netopil, M.; Paunzen, E.; Heiter, U.; Soubiran, C.

    2016-03-01

    In Paper II (Heiter et al., Paper II 2014A&A...561A..93H) we have evaluated available spectroscopic iron abundance determinations of open cluster stars and presented mean values for 78 open clusters. The results are based on high-resolution data (R>=25000) with high signal-to-noise ratios (S/N>=50). Furthermore, quality criteria were introduced by adopting only [Fe/H] measurements of stars with Teff=4400-6500K and logg>=2.0dex. We have to note that the mean iron abundance for Berkeley 29, listed in Paper II, also incorporates some measurements based upon lower S/N data. In the present paper we therefore list the correct values for the higher and lower quality data. Since publication of Paper II, some new studies were made (Boesgaard et al., 2013ApJ...775...58B; Bocek Topcu et al., 2015, Cat. J/MNRAS/446/3562; Carraro et al., 2014A&A...568A..86C; Donati et al., 2015, Cat. J/MNRAS/446/1411; Magrini et al.. 2014A&A...563A..44M, 2015A&A...580A..85M; Molenda-Zakowicz et al., 2014MNRAS.445.2446M; Monaco et al., 2014A&A...564L...6M; Reddy et al., 2015MNRAS.450.4301R), which we examined the same way as described in Paper II. This adds ten open clusters to our list (Berkeley 81, NGC 1342, NGC 1662, NGC 1912, NGC 2354, NGC 4337, NGC 4815, NGC 6811, Trumpler 5, and Trumpler 20) and supplementary data for NGC 752, NGC 2447, NGC 2632, and NGC 6705. (1 data file).

  13. A clinical study of canine collagen type III glomerulopathy

    PubMed Central

    2013-01-01

    Background Collagen type III glomerulopathy (Col3GP), also known as collagenofibrotic glomerulonephropathy, is a rare renal disease with unknown pathogenesis that occurs in animals and humans. We recently described a naturally occurring canine autosomal recessive model of Col3GP, and the aim of the present work was to study the clinical features of canine Col3GP and compare with the human phenotype. In humans two different clinical syndromes with different age at onset (child- or adulthood) have been observed. In children a more aggressive course with familial occurrence is described, characterized by progressively increasing proteinuria, nephrotic syndrome, hypertension and chronic renal failure. A markedly increased serum level of the aminoterminal propeptide of type III procollagen (PIIINP) is considered a useful marker for the disease. Since Col3GP and concurrent hypocomplementemia have been observed in humans, we also aimed to investigate if hypocomplementemia was present in Col3GP affected dogs. A litter consisting of seven puppies, four Col3GP affected and three healthy unaffected, was observed from the day of birth until the affected puppies developed a mild or moderate renal azotemia. Results During the period of observation growth retardation, increasing blood pressure, progressive proteinuria, azotemia, hypoalbuminemia, hypercholesterolemia and increased serum PIIINP were observed in all the affected dogs. Hypocomplementemia was not detected. Affected dogs were euthanized between 109 and 144 days of age, and pathological examinations revealed ascites and massive glomerular accumulations of collagen type III, consistent with Col3GP. Conclusions Dogs with Col3GP develop juvenile chronic renal failure, preceded by nephrotic syndrome, elevated serum PIIINP and hypertension, thus have similar clinical features as the juvenile Col3GP in humans. Further studies of this naturally occurring canine phenotype may provide more information on the pathogenesis and

  14. Ion implantation and annealing studies in III-V nitrides

    SciTech Connect

    Zolper, J.C.; Pearton, S.J.; Williams, J.S.; Tan, H.H.; Karlicek, R.J. Jr.; Stall, R.A.

    1996-12-31

    Ion implantation doping and isolation is expected to play an enabling role for the realization of advanced III-Nitride based devices. In fact, implantation has already been used to demonstrate n- and p-type doping of GaN with Si and Mg or Ca, respectively, as well as to fabricate the first GaN junction field effect transistor. Although these initial implantation studies demonstrated the feasibility of this technique for the III-Nitride materials, further work is needed to realize its full potential. After reviewing some of the initial studies in this field, the authors present new results for improved annealing sequences and defect studies in GaN. First, sputtered AlN is shown by electrical characterization of Schottky and Ohmic contacts to be an effect encapsulant of GaN during the 1,100 C implant activation anneal. The AlN suppresses N-loss from the GaN surface and the formation of a degenerate n{sup +}-surface region that would prohibit Schottky barrier formation after the implant activation anneal. Second, they examine the nature of the defect generation and annealing sequence following implantation using both Rutherford Backscattering (RBS) and Hall characterization. They show that for a Si-dose of 1 x 10{sup 16} cm{sup {minus}2} 50% electrical donor activation is achieved despite a significant amount of residual implantation-induced damage in the material.

  15. Inside Open Learning. Studies in Further Education.

    ERIC Educational Resources Information Center

    Bagley, Bill; Challis, Bob

    A study examined the experience of teachers, students, and college administrators in the following three open learning schemes for adult students in Great Britain: Flexistudy at Abraham Moss Open College, the mathematics and communications workshops at Bradford College, and the Technical Education Council programs at Moston College of Further…

  16. Synthesis and Structural Studies of Gallium(III) and Iron(III) Hemicryptophane Complexes.

    PubMed

    Gosse, Isabelle; Robeyns, Koen; Bougault, Catherine; Martinez, Alexandre; Tinant, Bernard; Dutasta, Jean-Pierre

    2016-02-01

    New gallium(III) and iron(III) endohedral complexes were obtained from a hemicryptophane ligand bearing suitable binding sites for octahedral metal coordination. The solid-state structures of the free host and of the complexes were determined by single-crystal X-ray diffraction analysis. The metal ion is linked to the hydrazone nitrogen and the phenolate oxygen atoms, yielding a distorted octahedral geometry around the encapsulated metal. The two isomorphous structures of the metal complexes reveal the exclusive formation of PΔ/MΛ enantiomeric pairs.

  17. Spectroscopic studies on unexpected complex azides of lanthanum(III) and neodymium(III)

    NASA Astrophysics Data System (ADS)

    Popitsch, A.; Mautner, A.; Fritzer, H. P.

    Solid azides of the types Cs 3La(N 3) 6, Cs 2Nd(N 3) 5, and Cs 4Nd(N 3) 7 can be prepared by metathetical reactions under special precautions. Electronic spectra in diffuse reflectance, infrared and Raman spectra, and magnetic susceptibilities versus temperature and field strength were measured on microcrystalline samples. The data of these new compounds are primarily discussed in view of vibrational properties of the azide ion N 3-, as ligand and in relation to first insights into the nature of the metal-nitrogen bonds within the coordination polyhedra of La(III) and Nd(III).

  18. Open-chamber combustion study

    NASA Astrophysics Data System (ADS)

    Meyers, D. P.; Meyer, R. C.

    1994-04-01

    The test program was undertaken to research trade-offs between engine design and operational parameters on open-chamber, premixed spark-ignited gas engines, with a primary focus on combustion effects. This included combustion chamber designs which are conceptually diametrically opposed -- a high squish design typical of diesel engines and a virtually quiescent design. The reader should note that these data are somewhat abstract compared to conventional engines, because the Labeco test engine has exceptionally high friction and the lean-burn data were run unboosted.

  19. Correction of dental Class III with posterior open bite by simple biomechanics using an anterior C-tube miniplate

    PubMed Central

    Ahn, Hyo-Won; Chung, Kyu-Rhim; Kang, Suk-Man; Lin, Lu; Nelson, Gerald

    2012-01-01

    In the correction of dental Class III molar relationship in skeletal Class II patients, uprighting of the mandibular posterior segments without opening the mandible is an important treatment objective. In the case reported herein, a C-tube miniplate fixed to the lower labial symphysis and connected with a nickel-titanium reverse-curved archwire provided effective uprighting of the lower molars, without the need of orthodontic appliances on the mandibular anteriors. Using this approach, an appropriate magnitude of force is exerted on the molars while avoiding any negative effect on the mandibular anteriors. PMID:23173121

  20. Search for giant planets in M67. III. Excess of hot Jupiters in dense open clusters

    NASA Astrophysics Data System (ADS)

    Brucalassi, A.; Pasquini, L.; Saglia, R.; Ruiz, M. T.; Bonifacio, P.; Leão, I.; Canto Martins, B. L.; de Medeiros, J. R.; Bedin, L. R.; Biazzo, K.; Melo, C.; Lovis, C.; Randich, S.

    2016-07-01

    Since 2008 we used high-precision radial velocity (RV) measurements obtained with different telescopes to detect signatures of massive planets around main-sequence and evolved stars of the open cluster (OC) M67. We aimed to perform a long-term study on giant planet formation in open clusters and determine how this formation depends on stellar mass and chemical composition. A new hot Jupiter (HJ) around the main-sequence star YBP401 is reported in this work. An update of the RV measurements for the two HJ host-stars YBP1194 and YBP1514 is also discussed. Our sample of 66 main-sequence and turnoff stars includes 3 HJs, which indicates a high rate of HJs in this cluster (5.6% for single stars and 4.5%% for the full sample). This rate is much higher than what has been discovered in the field, either with RV surveys or by transits. High metallicity is not a cause for the excess of HJs in M67, nor can the excess be attributed to high stellar masses. When combining this rate with the non-zero eccentricity of the orbits, our results are qualitatively consistent with a HJ formation scenario dominated by strong encounters with other stars or binary companions and subsequent planet-planet scattering, as predicted by N-body simulations. Based on observations collected at the ESO 3.6 m telescope (La Silla), at the 1.93 m telescope of the Observatoire de Haute-Provence (OHP), at the Hobby Eberly Telescope (HET), at the Telescopio Nazionale Galileo (TNG, La Palma) and at the Euler Swiss Telescope.

  1. Observing Protein & Energy Nutrition (OPEN) Study

    Cancer.gov

    The Observing Protein and Energy Nutrition (OPEN) Study was designed to assess dietary measurement error by comparing results from self-reported dietary intake data with four dietary biomarkers: doubly labeled water and urinary nitrogen, sodium, and potassium.

  2. Preparation and spectroscopic studies of antimony(III) and bismuth(III) halodithiocarbamate derivatives

    NASA Astrophysics Data System (ADS)

    Giusti, Aleardo; Preti, Carlo; Tosi, Giuseppe; Zannini, Paolo

    1983-04-01

    The complexes of antimony(III) and bismuth(III) with piperidine (Pipdtc), morpholine (Morphdtc) and thiomorpholinedithiocarbamate (Timdtc) of general formula Sb 2-(Rdtc) 3X 3 and M(Rdtc)X 2 (M is antimony or bismuth, X a halogen and Rdtc the dithiocarbamates) have been prepared and characterized by spectroscopic methods. The IR spectra suggest that the dithiocarbamate group coordinates as a bidentate ligand; the metal-sulphur and metal-halide stretching modes have also been assigned. The spectral data are discussed and compared with those of the corresponding trisdithiocarbamate and monohalobisdithiocarbamate derivatives. The molecular weight determinations indicate that all these dithiocarbamate complexes are dimeric. Tentative stereochemistries are proposed and discussed on the basis of the results obtained.

  3. Different Interaction Mechanisms of Eu(III) and (243)Am(III) with Carbon Nanotubes Studied by Batch, Spectroscopy Technique and Theoretical Calculation.

    PubMed

    Wang, Xiangxue; Yang, Shubin; Shi, Weiqun; Li, Jiaxing; Hayat, Tasawar; Wang, Xiangke

    2015-10-01

    Herein the sorption of Eu(III) and (243)Am(III) on multiwalled carbon nanotubes (CNTs) are studied, and the results show that Eu(III) and (243)Am(III) could form strong inner-sphere surface complexes on CNT surfaces. However, the sorption of Eu(III) on CNTs is stronger than that of (243)Am(III) on CNTs, suggesting the difference in the interaction mechanisms or properties of Eu(III) and (243)Am(III) with CNTs, which is quite different from the results of Eu(III) and (243)Am(III) interaction on natural clay minerals and oxides. On the basis of the results of density functional theory calculations, the binding energies of Eu(III) on CNTs are much higher than those of (243)Am(III) on CNTs, indicating that Eu(III) could form stronger complexes with the oxygen-containing functional groups of CNTs than (243)Am(III), which is in good agreement with the experimental results of higher sorption capacity of CNTs for Eu(III). The oxygen-containing functional groups contribute significantly to the uptake of Eu(III) and (243)Am(III), and the binding affinity increases in the order of ≡S-OH < ≡S-COOH < ≡S-COO(-). This paper highlights the interaction mechanism of Eu(III) and (243)Am(III) with different oxygen-containing functional groups of CNTs, which plays an important role for the potential application of CNTs in the preconcentration, removal, and separation of trivalent lanthanides and actinides in environmental pollution cleanup. PMID:26371690

  4. Conservative treatment for a growing patient with a severe, developing skeletal Class III malocclusion and open bite.

    PubMed

    Xu, Yue; Zhu, Ping; Le, Linda; Cai, Bin

    2014-06-01

    An 8-year-old Chinese girl sought treatment for a severe skeletal Class III malocclusion and open-bite skeletal pattern. Traditionally, patients with a skeletal Class III malocclusion are treated after they have stopped growing, and then they are treated with a combined orthodontic and orthognathic surgery approach. But the risks and expenses of this treatment plan are not acceptable to all patients. This young patient was treated with facemask therapy, a maxillary expansion device, and a molar occlusal splint for maxillary developmental stimulation with control of vertical jaw growth. After the completion of orthopedic therapy, 2 × 4 technology was used to adjust molar positions. A bonded tongue crib was used in the early permanent dentition to help the patient break her bad tongue habits. Straight-wire appliances were used for 16 months to adjust the occlusal relationship. This achieved significant improvement in anterior tooth relationships and facial profile esthetics. At the 2-year posttreatment follow-up, the results were satisfactory. The success of the sagittal relationship correction between the maxilla and the mandible for a skeletal Class III malocclusion depends on the coordination of transverse and vertical relationships combined with the growth potential of each patient.

  5. Conservative treatment for a growing patient with a severe, developing skeletal Class III malocclusion and open bite.

    PubMed

    Xu, Yue; Zhu, Ping; Le, Linda; Cai, Bin

    2014-06-01

    An 8-year-old Chinese girl sought treatment for a severe skeletal Class III malocclusion and open-bite skeletal pattern. Traditionally, patients with a skeletal Class III malocclusion are treated after they have stopped growing, and then they are treated with a combined orthodontic and orthognathic surgery approach. But the risks and expenses of this treatment plan are not acceptable to all patients. This young patient was treated with facemask therapy, a maxillary expansion device, and a molar occlusal splint for maxillary developmental stimulation with control of vertical jaw growth. After the completion of orthopedic therapy, 2 × 4 technology was used to adjust molar positions. A bonded tongue crib was used in the early permanent dentition to help the patient break her bad tongue habits. Straight-wire appliances were used for 16 months to adjust the occlusal relationship. This achieved significant improvement in anterior tooth relationships and facial profile esthetics. At the 2-year posttreatment follow-up, the results were satisfactory. The success of the sagittal relationship correction between the maxilla and the mandible for a skeletal Class III malocclusion depends on the coordination of transverse and vertical relationships combined with the growth potential of each patient. PMID:24880852

  6. Synthesis, structure and luminescence studies of Eu(III), Tb(III), Sm(III), Dy(III) cationic complexes with acetylacetone and bis(5-(pyridine-2-yl)-1,2,4-triazol-3-yl)propane☆

    PubMed Central

    Gusev, Alexey N.; Hasegawa, Miki; Shimizu, Tomohito; Fukawa, Tomonori; Sakurai, Shoya; Nishchymenko, Galyna A.; Shul’gin, Victor F.; Meshkova, Svetlana B.; Linert, Wolfgang

    2013-01-01

    Studies concerning synthesis, structure and luminescence of eight-coordinate Eu, Tb, Sm and Dy complexes of the type [Ln(acac)2(L)]Cl (Hacac = pentanedione-2,4 and L = bis(5-(pyridine-2-yl)-1,2,4-triazol-3-yl)propane) are reported in detail. The obtained complexes were investigated by various means including elemental- and thermogravimetric analysis, IR- and electron transition spectroscopy. The structure of the Tb complex was determined by single-crystal X-ray crystallography: Tb is eight-coordinate, and L acting only as a tetradentate chelate together with two bidentate acac ligands. Photophysical studies of the complexes were carried out. The Tb(III) and Eu(III) complexes show strong emissions both in solid state and solution. The intensity of the luminescence of Dy(III) and Sm(III) are relatively weak. The factors determining the intensity of the photoluminescence are discussed. PMID:24068839

  7. Comparison of Primary Radial Head Replacement and ORIF (Open Reduction and Internal Fixation) in Mason Type III Fractures: A Retrospective Evaluation in 72 Elderly Patients

    PubMed Central

    Liu, Run; Liu, Pengcheng; Shu, Hexi; Gong, Jinpeng; Sun, Qi; Wu, Jiezhou; Nie, Xiaoyang; Yang, Yong; Cai, Ming

    2015-01-01

    Background The aim of this study was to compare radial head prosthesis replacement with open reduction and internal fixation (ORIF) in the surgical treatment of Mason type III radial head fractures in 72 elderly patients. Material/Methods Seventy-two elderly patients (mean age, 67.1±1.25 years, range, 62–81 years) with Mason type III radial head fractures were treated from January 2001 to June 2012. Of these, 37 cases received radial prosthesis and 35 cases were treated with ORIF. All patients were followed up for 10 to 15.6 months. Results Based on the elbow functional evaluation criteria score by Broberg and Morrey, 29 cases achieved excellent results, 7 were good, and 1 was fair in the replacement group. In the ORIF group, excellent results were seen in 24 cases, good in 9, and fair in 2. The rates of good or excellent results were 78.4% and 68.6% for prosthesis replacement patients and ORIF patients, respectively (P<0.05). The Visual Analogue Scores (VAS) for replacement and ORIF groups were 2.25 and 1.67, respectively (P<0.05). Conclusions The radial head prosthesis replacement method is a relatively better surgical approach than ORIF in the treatment of elderly patients with Mason type III radial head fractures. PMID:25567738

  8. Selectivity enhancement of Arsenazo(III) reagent towards heavier lanthanides using polyaminocarboxylic acids: A spectrophotometric study

    NASA Astrophysics Data System (ADS)

    Matharu, Komal; Mittal, Susheel K.; Ashok Kumar, S. K.; Sahoo, Suban K.

    2015-06-01

    A new study has been conducted to quantify lanthanide(III) ions using Arsenazo III-polyaminocarboxylic acid (PACA) system. The study disclosed two different analytically important information: (i) λmax of lanthanide-Arsenazo III complexes for lighter lanthanides like Ce(III) and Nd(III) did not shift from its original position on addition of PACA and (ii) for heavier lanthanides like Dy(III), Tm(III) and Lu(III) a new λmax at 538 nm was observed, while wavelengths at 610 nm and 654 nm were disappeared in presence of ethylenediaminetertracetic acid (EDTA) and trans-1,2-Diaminocyclohexane-N,N,N‧,N‧-tetraacetic acid (DCTA), further the intensity of peak decreased with increase in lanthanide(III) ion concentration. Effect of ethylene glycol-bis(2-aminoethylether)-N,N,N‧,N‧-tetraacetic acid (EGTA) and N-(2-hydroxyethyl) ethylenediamine-N,N‧,N‧-triacetic acid (EDTA-OH) on Arsenzo(III)-Ln(III) complex is very weak and there is no analytically importance of such interaction. Moreover, this work confirms that Nd(III) and heavy lanthanides can be successfully determined with high accuracy in the working range of concentration of these metal ions.

  9. Hohlraum energetics study on Shenguang-III prototype laser facility

    NASA Astrophysics Data System (ADS)

    Yang, Dong; Li, Sanwei; Li, Zhichao; Yi, Rongqing; Guo, Liang; Jiang, Xiaohua; Liu, Shenye; Yang, Jiamin; Jiang, Shaoen; Ding, Yongkun; Zou, Shiyang; Zhang, Huasen; Zhao, Yiqing; Huo, Wenyi; Li, Xin; Li, Yongsheng; Lan, Ke

    2014-10-01

    Comprehensive and accurate characterization of the hohlraum drive needs to use a variety of methods resolving different photon ranges and multiple viewing areas. In recent years, hohlraum physics have been studied extensively on Shenguang-III prototype laser facility. These experiments employed mainly Au hohlraums (vaccum or gas-filled, with capsule or not) heated by smoothing beams where scattering loss is less than 10%. With compact flat-response x-ray detector array and 14-channel soft x-ray spectrometer, the radiation flux from several specific regions inside the hohlraum is measured through the laser entrance hole (LEH) or the diagnostic hole (DH) at different photon ranges and multiple lines of sight. The difference in radiation between the laser spot and the reemitting wall is quantitatively studied to interpret flux onto the capsule. The motion of laser ablated bubble and radiation ablated blow-off plasma is directly measured, and their effects on laser absorption and x-ray escaping LEH are evaluated. In addition, the radiation driven shock propagating in Al and Ti placed on the hohlraum wall, which is more representative of the drive inside the hohlraum, provide a unique information of radiation.

  10. Hohlraum energetics study on Shenguang-III prototype laser facility

    NASA Astrophysics Data System (ADS)

    Yang, Dong; Li, Sanwei; Li, Zhichao; Yi, Rongqing; Guo, Liang; Jiang, Xiaohua; Liu, Shenye; Yang, Jiamin; Jiang, Shaoen; Ding, Yongkun; Zou, Shiyang; Zhao, Yiqing; Li, Xin; Huo, Wenyi; Zhang, Huasen; Li, Yongsheng; Lan, Ke

    2013-10-01

    Comprehensive and accurate characterization of hohlraum drive need to use a variety of methods resolving different photon range and multiple viewing area. In recent years, hohlraum physics have been studied extensively on Shenguang-III prototype. These experiments employed mainly Au hohlraum with or without a capsule, heated by smoothing beams where scattering loss is less than 10%. With compact flat-response X-ray detector array and 14-channel soft X-ray spectrometer, the radiation flux is measured through the laser entrance hole (LEH) or diagnostic hole (DH) at different photon range and multiple line of sight. The difference in radiation between laser spot and re-emitting wall, the time history of capsule absorbing and emitting flux, is quantitatively studied to interpret flux onto the capsule. The radiation driven shock propagating in Al and Ti sample placed over a hole in the hohlraum wall, which is more representative of the drive inside the hohlraum, also provide a unique information of radiation. In order to better improve our physics model, the motion of laser ablated bubble and radiation ablated blow-off plasma is directly measured, and their effects on laser absorption and X-ray escaping LEH as well as flux diagnostics are evaluated.

  11. Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial

    PubMed Central

    Ellis, Paul; Barrett-Lee, Peter; Johnson, Lindsay; Cameron, David; Wardley, Andrew; O'Reilly, Susan; Verrill, Mark; Smith, Ian; Yarnold, John; Coleman, Robert; Earl, Helena; Canney, Peter; Twelves, Chris; Poole, Christopher; Bloomfield, David; Hopwood, Penelope; Johnston, Stephen; Dowsett, Mitchell; Bartlett, John MS; Ellis, Ian; Peckitt, Clare; Hall, Emma; Bliss, Judith M

    2009-01-01

    Summary Background Incorporation of a taxane as adjuvant treatment for early breast cancer offers potential for further improvement of anthracycline-based treatment. The UK TACT study (CRUK01/001) investigated whether sequential docetaxel after anthracycline chemotherapy would improve patient outcome compared with standard chemotherapy of similar duration. Methods In this multicentre, open-label, phase III, randomised controlled trial, 4162 women (aged >18 years) with node-positive or high-risk node-negative operable early breast cancer were randomly assigned by computer-generated permuted block randomisation to receive FEC (fluorouracil 600 mg/m2, epirubicin 60 mg/m2, cyclophosphamide 600 mg/m2 at 3-weekly intervals) for four cycles followed by docetaxel (100 mg/m2 at 3-weekly intervals) for four cycles (n=2073) or control (n=2089). For the control regimen, centres chose either FEC for eight cycles (n=1265) or epirubicin (100 mg/m2 at 3-weekly intervals) for four cycles followed by CMF (cyclophosphamide 600 mg/m2, methotrexate 40 mg/m2, and fluorouracil 600 mg/m2 at 4-weekly intervals) for four cycles (n=824). The primary endpoint was disease-free survival. Analysis was by intention to treat (ITT). This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN79718493. Findings All randomised patients were included in the ITT population. With a median follow-up of 62 months, disease-free survival events were seen in 517 of 2073 patients in the experimental group compared with 539 of 2089 controls (hazard ratio [HR] 0·95, 95% CI 0·85–1·08; p=0·44). 75·6% (95% CI 73·7–77·5) of patients in the experimental group and 74·3% (72·3–76·2) of controls were alive and disease-free at 5 years. The proportion of patients who reported any acute grade 3 or 4 adverse event was significantly greater in the experimental group than in the control group (p<0·0001); the most frequent events were neutropenia (937 events vs 797 events

  12. Studies on the sorption of praseodymium (III), holmium (III) and cobalt (II) from nitrate medium using TVEX-PHOR resin.

    PubMed

    El-Dessouky, S I; El-Sofany, E A; Daoud, J A

    2007-05-01

    The use of TVEX-PHOR resin for the sorption of praseodymium (III), holmium (III) and cobalt (II) from nitrate medium was carried out using batch and column techniques. Various parameters affecting the uptake of these metal ions such as v/m ratio, pH and the metal ion concentration were separately studied. Effect of temperature on the equilibrium distribution values has been studied to evaluate the changes in standard thermodynamic quantities. Experimental results of the investigated metal ions were found to fit to Freundlich isotherm model over the entire studied concentration range. Selectivity sequence of the resin for these metals is Ho>Pr>Co. The recovery of the investigated metals from the loaded resin is preformed with 0.1M sulphuric acid.

  13. Reactor physics studies in the GCFR Phase III critical assembly

    SciTech Connect

    Morman, J A

    1980-03-01

    The third phase of the gas cooled fast reactor (GCFR) program, ZPR-9 Assembly 30, is based on a multi-zoned core of PuO/sub 2/-UO/sub 2/ with radial and axial blankets of UO/sub 2/. Studies performed in this assembly will be compared to the previous phases of the GCFR program and will help to define parameters in this power-flattened demonstration plant-type core. Measurements in the Phase III program included small sample reactivity worths of various materials, central reaction rates and reaction rate distributions, absorption-to-fission ratios and the central point conversion ratio and the worth of steam entry into a small central zone. The reactivity change associated with the construction of a central pin zone in the core and axial blanket was measured. Reaction rate and steam entry measurements were repeated in the pin environment. Standard analysis methods using ENDF/B-IV data are described and the results are compared to measurements performed during the program.

  14. GLASS COMPOSITIONS FOR THE NEPHELINE PHASE III STUDY

    SciTech Connect

    Fox, K.; Edwards, T.

    2009-06-29

    A series of 29 test glass compositions were selected for Phase III of the nepheline study using a combination of two approaches. The first approach was based on evaluating the glass composition region allowable by all of the Defense Waste Processing Facility (DWPF) Product Composition Control System (PCCS) models with the exception of the current nepheline discriminator. This approach was taken to determine whether there are glass compositions that, while predicted to crystallize nepheline upon slow cooling, would otherwise be acceptable for processing in the DWPF. The second approach was based on quasicrystalline theory of glass structure, which helped predict compositional regions where nepheline should form. A detailed description of this methodology is forthcoming. The selection strategy outlined here will provide an opportunity to determine experimentally whether the glasses that fail the current nepheline discriminator but pass the newly proposed nepheline discriminator are indeed free of nepheline after slow cooling. If this is the case, these data will serve as a significant step toward reducing conservatism in the current nepheline discriminator. The 29 glass compositions selected for testing address both the PCCS model and quasicrystalline theory approaches in evaluating both a reduction in conservatism for the current nepheline discriminator and possible implementation of the newly proposed discriminator based on glass structural theory. These glasses will be fabricated and characterized in the laboratory, with the results and conclusions described in a technical report.

  15. Evaluation of the MOZAIC Capacitive Hygrometer during the airborne field study CIRRUS-III

    NASA Astrophysics Data System (ADS)

    Neis, P.; Smit, H. G. J.; Krämer, M.; Spelten, N.; Petzold, A.

    2015-03-01

    The MOZAIC Capacitive Hygrometer (MCH) is usually operated aboard passenger aircraft in the framework of MOZAIC (Measurement of Ozone by Airbus In-Service Aircraft) for measuring atmospheric relative humidity (RH). In order to evaluate the performance of the MCH, the instrument was operated aboard a Learjet 35A research aircraft as part of the CIRRUS-III field study together with a closed-cell Lyman-α fluorescence hygrometer (Fast in situ Stratospheric Hygrometer, or FISH) and an open-path tunable diode laser system (Open-path Jülich Stratospheric TDL ExpeRiment, or OJSTER) for water vapour measurement. After reducing the CIRRUS-III data set to data corresponding to MOZAIC aircraft operation conditions, the 1 Hz RH data cross correlation between the MCH and reference instruments FISH (clear sky) and OJSTER (in-cirrus) yielded a remarkably good agreement of R2 = 0.92 and slope m = 1.02 and provided a MCH uncertainty of 5% RH. Probability distribution functions of RH deduced from the MCH and reference instruments agreed well between 10 and 70% RH with respect to liquid water in the ambient temperature range of ca. -70 to -40 °C. The use of MCH data is limited to sensor temperatures above the calibration limit of Tsensor = -40 °C (corresponds to ambient temperature of Tambient = -70 °C at typical cruising speed of long-haul passenger aircraft). Good performance of the MCH for clear sky as well as for in-cirrus conditions demonstrated the sensor robustness also for operation inside ice clouds.

  16. EXPERIMENTAL RESULTS OF THE NEPHELINE PHASE III STUDY

    SciTech Connect

    Fox, K.; Edwards, T.

    2009-11-09

    This study is the third phase in a series of experiments designed to reduce conservatism in the model that predicts the formation of nepheline, a crystalline phase that can reduce the durability of high level waste glass. A Phase I study developed a series of glass compositions that were very durable while their nepheline discriminator values were well below the current nepheline discriminator limit of 0.62, where nepheline is predicted to crystallize upon slow cooling. A Phase II study selected glass compositions to identify any linear effects of composition on nepheline crystallization and that were restricted to regions that fell within the validation ranges of the Defense Waste Processing Facility (DWPF) Product Composition Control System (PCCS) models. However, it was not possible to identify any linear effects of composition on chemical durability performance for this set of study glasses. The results of the Phase II study alone were not sufficient to recommend modification of the current nepheline discriminator. It was recommended that the next series of experiments continue to focus not only on compositional regions where the PCCS models are considered applicable (i.e., the model validation ranges), but also be restricted to compositional regions where the only constraint limiting processing is the current nepheline discriminator. Two methods were used in selecting glasses for this Phase III nepheline study. The first was based on the relationship of the current nepheline discriminator model to the other DWPF PCCS models, and the second was based on theory of crystallization in mineral and glass melts. A series of 29 test glass compositions was selected for this study using a combination of the two approaches. The glasses were fabricated and characterized in the laboratory. After reviewing the data, the study glasses generally met the target compositions with little issue. Product Consistency Test results correlated well with the crystallization analyses in

  17. 77 FR 62518 - Proposed Collection; Comment Request: Recipient Epidemiology and Donor Evaluation Study-III (REDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...: Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Type of Information Collection Request: New. Need and Use of Information Collection: The objective of the Recipient Epidemiology and Donor... medical procedures. REDS-II conducted studies of blood donor health but much more needs to be...

  18. The Xanthomonas campestris Type III Effector XopJ Proteolytically Degrades Proteasome Subunit RPT61[OPEN

    PubMed Central

    2015-01-01

    Many animal and plant pathogenic bacteria inject type III effector (T3E) proteins into their eukaryotic host cells to suppress immunity. The Yersinia outer protein J (YopJ) family of T3Es is a widely distributed family of effector proteins found in both animal and plant pathogens, and its members are highly diversified in virulence functions. Some members have been shown to possess acetyltransferase activity; however, whether this is a general feature of YopJ family T3Es is currently unknown. The T3E Xanthomonas outer protein J (XopJ), a YopJ family effector from the plant pathogen Xanthomonas campestris pv vesicatoria, interacts with the proteasomal subunit Regulatory Particle AAA-ATPase6 (RPT6) in planta to suppress proteasome activity, resulting in the inhibition of salicylic acid-related immune responses. Here, we show that XopJ has protease activity to specifically degrade RPT6, leading to reduced proteasome activity in the cytoplasm as well as in the nucleus. Proteolytic degradation of RPT6 was dependent on the localization of XopJ to the plasma membrane as well as on its catalytic triad. Mutation of the Walker B motif of RPT6 prevented XopJ-mediated degradation of the protein but not XopJ interaction. This indicates that the interaction of RPT6 with XopJ is dependent on the ATP-binding activity of RPT6, but proteolytic cleavage additionally requires its ATPase activity. Inhibition of the proteasome impairs the proteasomal turnover of Nonexpressor of Pathogenesis-Related1 (NPR1), the master regulator of salicylic acid responses, leading to the accumulation of ubiquitinated NPR1, which likely interferes with the full induction of NPR1 target genes. Our results show that YopJ family T3Es are not only highly diversified in virulence function but also appear to possess different biochemical activities. PMID:25739698

  19. Mechanistic study of the reaction of L-ascorbic acid with hexacyanometalate(III) ions of iron(III), ruthenium(III), and osmium(III) in aqueous acidic solution at elevated pressures

    SciTech Connect

    Kagayama, Nobuyoshi; Sekiguchi, Mitsuhiro; Inada, Yasuhiro; Takagi, Hideo D.; Funahashi, Shigenobu )

    1994-04-27

    Oxidation reactions of L-ascorbic acid by three hexacyanometalate(III) ions in aqueous acidic media are studied at elevated pressures. Kinetic parameters characterizing two parallel paths involving ascorbic acid (H[sub 2]Asc) and ascorbate ion (HAsc[sup [minus

  20. Los Angeles International Airport Runway Incursion Studies: Phase III--Center-Taxiway Simulation

    NASA Technical Reports Server (NTRS)

    Madson, Michael D.

    2004-01-01

    Phase III of the Los Angeles International Airport Runway Incursion Studies was conducted, under an agreement with HNTB Corporation, at the NASA Ames FutureFlight Central (FFC) facility in June 2003. The objective of the study was the evaluation of a new center-taxiway concept at LAX. This study is an extension of the Phase I and Phase II studies previously conducted at FFC. This report presents results from Phase III of the study, in which a center-taxiway concept between runways 25L and 25R was simulated and evaluated. Phase III data were compared objectively against the Baseline data. Subjective evaluations by participating LAX controllers were obtained with regard to workload, efficiency, and safety criteria. To facilitate a valid comparison between Baseline and Phase III data, the same scenarios were used for Phase III that were tested during Phases I and II. This required briefing participating controllers on differences in airport and airline operations between 2001 and today.

  1. Three-dimensional open-frameworks based on Ln(III) ions and open-/closed-shell PTM ligands: synthesis, structure, luminescence, and magnetic properties.

    PubMed

    Datcu, Angela; Roques, Nans; Jubera, Véronique; Imaz, Inhar; Maspoch, Daniel; Sutter, Jean-Pascal; Rovira, Concepció; Veciana, Jaume

    2011-03-21

    A series of isostructural open-framework coordination polymers formulated as [Ln(dmf)(3)(ptmtc)] (Ln = Sm (1), Eu (2), Gd (3), Tb (4), Dy (5); PTMTC = polychlorotriphenylmethyl tricarboxylate) and [Ln(dmf)(2)H(2)O(αH-ptmtc)] (Ln = Sm (1'), Eu (2'), Gd (3'), Tb (4'), Dy (5')) have been obtained by treating Ln(III) ions with PTMTC ligands with a radical (PTMTC(3-)) or a closed-shell character (αH-PTMTC(3-)). X-ray diffraction analyses reveal that these coordination polymers possess 3D architectures that combine large channels and fairly rare lattice complex T connectivity. In addition, these compounds show selective framework dynamic sorption properties. For both classes of ligands, the ability to act as an antenna in Ln sensitization processes has been investigated. No luminescence was observed for compounds 1-5, and 3' because of the PTMTC(3-) ligand and/or Gd(III) ion characteristics. Conversely, photoluminescence measurements show that 1', 2', 4', and 5' emit dark orange, red, green, and dark cyan metal-centered luminescence. The magnetic properties of all of these compounds have been investigated. The nature of the {Ln-radical} exchange interaction in these compounds has been assessed by comparing the behavior of the radical-based coordination polymers 1-5 with those of the compounds with the diamagnetic ligand set. While antiferromagnetic {Sm-radical} interactions are found in 1, ferromagnetic {Ln-radical} interactions propagate in the 3D architectures of 3, 4, and 5 (Ln = Gd, Tb, and Dy, respectively). This procedure also provided access to information on the {Ln-Ln} exchange existing in these magnetic systems.

  2. Open clusters in the Third Galactic Quadrant III. Alleged binary clusters

    NASA Astrophysics Data System (ADS)

    Vázquez, R. A.; Moitinho, A.; Carraro, G.; Dias, W. S.

    2010-02-01

    Aims: We aim to determine accurate distances and ages of eight open clusters in order to: (1) assess their possible binarity (2) provide probes to trace the structure of the Third Galactic Quadrant. Methods: Cluster reddenings, distances, ages and metallicities are derived from ZAMS and isochrone fits in UBVRI photometric diagrams. Field contamination is reduced by restricting analysis to stars within the cluster limits derived from star counts. Further membership control is done by requiring that stars have consistent positions in several diagrams and by using published spectral types. Results: The derived distances, ages and metallicities have shown that none of the analysed clusters compose binary/double systems. Of the four candidate pairs, only NGC 2383/NGC 2384 are close to each other, but have different metallicities and ages. Ruprecht 72 and Ruprecht 158 are not clusters but fluctuations of the field stellar density. Haffner 18 is found to be the superposition of two stellar groups at different distances: Haffner 18(1) at 4.5 kpc and Haffner 18(2) between 9.5 and 11.4 kpc from the Sun. The derived distances and ages have been used to situate the clusters in the Galactic context. In particular, young stellar groups trace spiral structure at large Galactocentric radii. At least two clusters formed during the last few 108 yr in an interstellar medium with less than solar abundances. Conclusions: In contrast with the LMC, double clusters are apparently rare, or even non existent, in the undisturbed environment of the Third Galactic Quadrant. This leaves open the question of whether binary clusters form more easily toward denser and more violent regions of the Milky Way such as the inner Galaxy. The original photometry is only available in electronic form at CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/511/A38on leave from Dipartimento di Astronomia, Università di Padova, Vicolo Osservatorio 2

  3. Statistical study of solar type III bursts and auroral kilometric radiation onsets

    SciTech Connect

    Farrell, W.M.; Gurnett, D.A.

    1985-10-01

    Simultaneous occurrences of type III solar radio bursts and auroral kilometric radiation were observed by Calvert using ISEE 1 spectrograms. He presented evidence suggesting that the incoming type III burst stimulates the onset of auroral kilometric radiation (AKR). This paper presents a statistical study of the correlation between type III bursts and auroral kilometric radiation. A superposed epoch analysis was performed on as many as 186 type III events. The type III bursts were detected by the ISEE 3 spacecraft on the sunward side of the earth. At the same time the IMP 8 spacecraft was used to detect onsets of kilometric radiation on the nightside of the earth. For each event the intensities measured by ISEE 3(type III intensities) were subtracted from the intensities measured by IMP 8 (type III and possible AKR intensities). The resulting intensities for each event were then added to determine if kilometric radiation was preferentially observed following a type III burst. This analysis was performed at frequencies of 100, 178, and 500 kHz. The results of this study show that a statistically significant correlation exists between incoming type III bursts from the sun and kilometric radiation from the earth.

  4. Study of holmium (III) and yttrium(III) with DOTA complexes as candidates for radiopharmaceutical use

    NASA Astrophysics Data System (ADS)

    Ernestová, M.; Jedináková-Křížová, V.

    2003-01-01

    Reaction conditions for complexation of radionuclides with DOTA were studied using thinlayer chromatography (TLC), paper chromatography (PC) and potentiometry. It was found that all of the studied complexes can reach very high radiochemical yield about 95%. Optimal conditions for obtaining such high radiochemical yields are as follows: pH higher than 4 and the excess of chelating agent must be minimally 3∶1. Potentiometric study showed that the formation of complexes is characterised by very slow kinetics.

  5. Environmental Technology Verification (ETV) Program Case Studies: Demonstrating Program Outcomes, Volume III

    EPA Science Inventory

    This booklet, ETV Program Case Studies: Demonstrating Program Outcomes, Volume III contains two case studies, addressing verified environmental technologies for decentalized wastewater treatment and converting animal waste to energy. Each case study contains a brief description ...

  6. A comparative study of internal fixation and prosthesis replacement for radial head fractures of Mason type III.

    PubMed

    Ruan, Hong-Jiang; Fan, Cun-Yi; Liu, Jun-Jian; Zeng, Bing-Fang

    2009-02-01

    Although several treatment options for radial head fractures are available, no clear solutions exist. In this study we therefore compare open reduction and internal fixation (ORIF) with bipolar radial head prosthesis replacement in treatment of radial head fractures of Mason type III. Cement stem and bipolar radial prosthesis were used to treat 12 fresh cases and two old cases of Mason type III radial head fracture. As a control group, another eight cases of radial head type III fracture were treated with ORIF with cannulated screws and Kirschner (K) wires. The 14 patients who received radial head prosthesis replacement were followed-up for 15.9 months (range 10-27 months). According to elbow functional evaluation criteria by Broberg and Morrey, we found excellent results in nine cases, good in four, and fair in one. Mean follow-up of the eight cases in the ORIF group was 14 months (range 10-21 months), with good results in one case, fair in four, and poor in three. The result was good or excellent in 92.9% of prosthesis replacement patients and in 12.5% of ORIF patients. This difference is statistically significant (P = 0.0004; Fisher's exact test). We concluded that bipolar radial head prosthesis replacement is better than ORIF in treatment of Mason type III radial head fracture. PMID:17938924

  7. Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.

    PubMed Central

    Panning, B; Smiley, J R

    1993-01-01

    We found that transcription of endogenous human Alu elements by RNA polymerase III was strongly stimulated following infection of HeLa cells with adenovirus type 5, leading to the accumulation of high levels of Alu transcripts initiated from Alu polymerase III promoters. In contrast to previously reported cases of adenovirus-induced activation of polymerase III transcription, induction required the E1b 58-kDa protein and the products of E4 open reading frames 3 and 6 in addition to the 289-residue E1a protein. In addition, E1a function was not required at high multiplicities of infection, suggesting that E1a plays an indirect role in Alu activation. These results suggest previously unsuspected regulatory properties of the adenovirus E1b and E4 gene products and provide a novel approach to the study of the biology of the most abundant class of dispersed repetitive DNA in the human genome. Images PMID:7684492

  8. Linkage studies in primary open angle glaucoma

    SciTech Connect

    Avramopoulos, D.; Grigoriadu, M.; Kitsos, G.

    1994-09-01

    Glaucoma is a leading cause of blindness worldwide. The majority of glaucoma is associated with an open, normal appearing anterior chamber angle and is termed primary open angle glaucoma (POAG, MIM 137760). It is characterized by elevated intraocular pressure and onset in middle age or later. A subset of POAG with juvenile onset has recently been linked to chromosome 1q in two families with autosomal dominant inheritance. Eleven pedigrees with autosomal dominant POG (non-juvenile-onset) have been identified in Epirus, Greece. In the present study DNA samples have been collected from 50 individuals from one large pedigree, including 12 affected individuals. Preliminary results of linkage analysis with chromosome 1 microsatellites using the computer program package LINKAGE Version 5.1 showed no linkage with the markers previously linked to juvenile-onset POAG. Further linkage analysis is being pursued, and the results will be presented.

  9. Arsenic(III) Removal from Contaminated Water using Silica Ceramic: A Batch Adsorption Study

    NASA Astrophysics Data System (ADS)

    Salim, Md.; Munekage, Yukihiro; Naing, Kyaw Min

    The silica ceramic (S-K) has been used as a potential low-cost adsorbent for the removal of As(III) from contaminated water in batch studies. Results showed that an adsorbent dose at 90 g L1 could effectively remove 96% of As(III) from initial concentration of 0.5 mg L1 within 3 h. It was also reveled that As(III) uptake increased with increasing contact time and As(III) concentration decreased with increasing adsorbent dosage. It was observed that As(III) removal is relatively dependent on pH and temperature variations. High adsorption of As(III) was found at pH 7.5 and at 25°C. The adsorption equilibrium data followed both Langmuir and Freundlich isotherms. The Freundlich isotherm provided the best correlation for the adsorption of As(III) onto the silica ceramic. The maximum capacity of adsorption was found (qm) 1.1041 mg g1 at different concentrations at 40 g L1 fixed adsorption dosage. The results suggest that silica ceramic (S-K) is a potential adsorbent for removal As(III) ions effectively from contaminated water.

  10. Tetrametallic lanthanide(III) phosphonate cages: synthetic, structural and magnetic studies.

    PubMed

    Zangana, Karzan H; Pineda, Eufemio Moreno; Winpenny, Richard E P

    2014-12-01

    The synthesis, structures and magnetic properties of a family of lanthanide complexes containing phosphonate ligands are reported. Reaction of hydrated lanthanide nitrate and (t)butylphosphonic acid under reflux conditions in iso-butanol, in the presence of pivalic acid as a co-ligand produced five new lanthanide complexes; pyridine (py) was present as a base. The compounds formed are tetrametallic, with the general formula [pyH]4[Ln4(μ3-OH)(O3P(t)Bu)3(HO3P(t)Bu)(O2C(t)Bu)2(NO3)6] where Ln = Gd(III), 1; Tb(III), 2; Dy(III), 3; Ho(III), 4 and Er(III), 5. The metal sites within the complexes lie on the vertices of a triangle-based pyramid, with phosphonate ligands on the triangular faces linking the apical Ln site to the Ln sites in the base. Each lanthanide(III) site is eight-coordinate. Magnetic studies of the compounds show a decline in the product χ(M)T with T; modelling the behaviour of 1 shows anti-ferromagnetic exchange between Gd(III) centres within the triangle with a negligible interaction to the fourth Gd(III) centre at the apex of the trigonal pyramid. PMID:25310820

  11. Alternative treatment for open bite Class III malocclusion in a child with Williams-Beuren syndrome

    PubMed Central

    Vieira, Giovanni Modesto; Franco, Eduardo Jacomino; da Rocha, Denise Falcão Pinheiro; de Oliveira, Laudimar Alves; Amorim, Rivadávio Fernandes Batista

    2015-01-01

    Williams-Beuren syndrome (WBS) is a rare genetic condition that affects approximately 1 in every 20,000 - 50,000 live births. WBS children have specific skeletal deformities, dental malformations and rare lingual muscle dysfunction. The need for orthodontic and orthognathic therapy has arisen and has been considered a real clinical challenge even for experienced professionals, once it requires a complex and individualized treatment plan. This study reports a case of orthopedic expansion of the maxilla, in which a modified facial mask was used for protraction of the maxillary complex associated with clockwise rotation of the maxilla. In addition, special considerations about treatment time and orthopedic outcomes are discussed. PMID:25741831

  12. Synthesis, characterization and DNA-binding studies on La(III) and Ce(III) complexes containing ligand of N-phenyl-2-pyridinecarboxamide

    NASA Astrophysics Data System (ADS)

    He, Xin-Qian; Lin, Qiu-Yue; Hu, Rui-Ding; Lu, Xiao-Hong

    2007-09-01

    La(III) and Ce(III) complexes containing ligand of N-phenyl-2-pyridinecarboxamide (HL) were synthesized and characterized by elemental analyses, conductivity measurement, IR spectra and thermal analysis. The general formulas of the complexes were [Ln(HL) 3(H 2O) 2](NO 3) 3·2H 2O [Ln = La(III), Ce(III)]. The results indicated that the oxygen of carbonyl and the nitrogen of pyridyl coordinated to Ln(III), and there were also two water molecules taking part in coordination. Ln(III) and HL formed 1:3 chelate complexes and the coordination number was eight. The interaction between the complexes and DNA was studied by means of UV-vis spectra, fluorescence spectra, SERS spectra and agarose gel electrophoresis. The results showed that complexes can bind to DNA. The binding ability decreased in following order: La(III) complex, Ce(III) complex, and HL. The interaction modes between DNA and the three compounds were found to be mainly intercalative.

  13. Evaluation of the MOZAIC Capacitive Hygrometer during the airborne field study CIRRUS-III

    NASA Astrophysics Data System (ADS)

    Neis, P.; Smit, H. G. J.; Krämer, M.; Spelten, N.; Petzold, A.

    2014-09-01

    The MOZAIC Capacitive Hygrometer (MCH) is usually operated onboard of passenger aircraft in the framework of MOZAIC (Measurement of Ozone by AIRBUS In-Service Aircraft). In order to evaluate the performance of the MCH, it was operated aboard a Learjet 35A aircraft as part of the CIRRUS-III field study together with a closed-cell Lyman-α fluorescence hygrometer (FISH) and an open path tunable diode laser system (OJSTER) for water vapour measurement. After reducing the data set to MOZAIC-relevant conditions, the 1Hz relative humidity (RH) cross correlation between MCH and reference instruments FISH (clear sky) and OJSTER (in-cirrus) yielded a remarkably good agreement of R2 = 0.97 and slope m = 0.96 and provided the MCH uncertainty of 5% RH. Probability distribution functions of RH deduced from MCH and reference instruments agreed well over the entire range of observations. The main limitation for the use of MCH data is related to sensor temperatures below the calibration limit of Tsensor = -40 °C (corresponds to ambient temperature of Tambient = -70 °C at typical cruising speed of long-haul passenger aircraft), which causes a delay in the sensor's time response. Good performance of MCH for clear sky as well as for in-cirrus conditions demonstrated the sensor robustness also for operation inside ice clouds.

  14. Oil geochemistry study; Blocks III and IV Bachaquedro Field, Lake Maracaibo, Venezuela

    SciTech Connect

    Patterson, B.A.; Villarroel, H.G. de; Rondon, L.

    1996-08-01

    Blocks III and IV Bachaquero, Field, located on the east side of Lake Maracaibo, comprise an area of 40 square kilometers. In 1956 the discovery well penetrated oil saturated sands in a south dipping homoclinal structure. In 1958 production reached a maximum of 245,000 barrels per day of moderate gravity oil from three Miocene age Lagunillas Formation sands, designated as L, M, and N. The Bachaquero Field has experienced production problems including high gas-oil ratios from M and N sands to the north, high water cuts in all three sands to the south, and low production rates in the southeast. In addition, the vertical and lateral continuity of the oil pools are unknown. High resolution gas chromatography and analysis of biological markers was employed in order to resolve the continuity of the oil pools, determine genetic origin of the oils, and shed light on erratic production. Oil in the L sands are vertically discontinuous from oil in the M+N sands. The two oil pools appear laterally continuous within the study area, indicating absence of fault barriers. Well VLD 311, open to both L and M sands, produces a mix of oils, but with a strong contribution from the M sand. Bachaquero Field reservoirs were charged with oil from two different facies of the Upper Cretaceous La Luna or perhaps from La Luna and Colon source rocks as the stratigraphically younger L sands contain less mature oil with a stronger terrigenous imprint than oil the M and N sands.

  15. Spectroscopic studies in open quantum systems

    PubMed

    Rotter; Persson; Pichugin; Seba

    2000-07-01

    The Hamiltonian H of an open quantum system is non-Hermitian. Its complex eigenvalues E(R) are the poles of the S matrix and provide both the energies and widths of the states. We illustrate the interplay between Re(H) and Im(H) by means of the different interference phenomena between two neighboring resonance states. Level repulsion may occur along the real or imaginary axis (the latter is called resonance trapping). In any case, the eigenvalues of the two states avoid crossing in the complex plane. We then calculate the poles of the S matrix and the corresponding wave functions for a rectangular microwave resonator with a scatter as a function of the area of the resonator as well as of the degree of opening to a waveguide. The calculations are performed by using the method of exterior complex scaling. Re(H) and Im(H) cause changes in the structure of the wave functions which are permanent, as a rule. The resonance picture obtained from the microwave resonator shows all the characteristic features known from the study of many-body systems in spite of the absence of two-body forces. The effects arising from the interplay between resonance trapping and level repulsion along the real axis are not involved in the statistical theory (random matrix theory).

  16. Towards an entirely endovascular aortic world: an update of techniques and outcomes for endovascular and open treatment of type I, II, and III endoleaks.

    PubMed

    Mangialardi, Nicola; Orrico, Matteo; Ronchey, Sonia; Praquin, Barbara; Alberti, Vittorio; Setacci, Carlo

    2016-10-01

    Endovascular aneurysm repair (EVAR) is largely the most adopted strategy for aneurysmal disease of the aorta. Nevertheless, the high incidence of reintervention makes it difficult to identify EVAR as a definitive solution; in particular, the most frequent indication of reintervention is endoleak, which is defined as persistent flow into the aneurysmal sac from different sources. Several treatment strategies are described. A contemporary literature search was performed with the intent of describing techniques and outcomes of endovascular and open strategies to type I, II, and III endoleak. Described techniques and outcomes were organized by indication (type I, II, and III endoleak) and by type of approach (endovascular, open, and laparoscopic) to give an overview of the current status of the treatment for the three most frequent types of endoleak. Several endovascular means are described in the literature for the treatment of endoleak.

  17. Towards an entirely endovascular aortic world: an update of techniques and outcomes for endovascular and open treatment of type I, II, and III endoleaks.

    PubMed

    Mangialardi, Nicola; Orrico, Matteo; Ronchey, Sonia; Praquin, Barbara; Alberti, Vittorio; Setacci, Carlo

    2016-10-01

    Endovascular aneurysm repair (EVAR) is largely the most adopted strategy for aneurysmal disease of the aorta. Nevertheless, the high incidence of reintervention makes it difficult to identify EVAR as a definitive solution; in particular, the most frequent indication of reintervention is endoleak, which is defined as persistent flow into the aneurysmal sac from different sources. Several treatment strategies are described. A contemporary literature search was performed with the intent of describing techniques and outcomes of endovascular and open strategies to type I, II, and III endoleak. Described techniques and outcomes were organized by indication (type I, II, and III endoleak) and by type of approach (endovascular, open, and laparoscopic) to give an overview of the current status of the treatment for the three most frequent types of endoleak. Several endovascular means are described in the literature for the treatment of endoleak. PMID:27465391

  18. Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral N,N'-Dioxide-Scandium(III) Complex.

    PubMed

    Xia, Yong; Lin, Lili; Chang, Fenzhen; Fu, Xuan; Liu, Xiaohua; Feng, Xiaoming

    2015-11-01

    A highly efficient asymmetric ring-opening reaction of cyclopropyl ketones with a broad range of thiols, alcohols and carboxylic acids has been first realized by using a chiral N,N'-dioxide-scandium(III) complex as catalyst. The corresponding sulfides, ethers, and esters were obtained in up to 99% yield and 95% ee. This is also the first example of one catalytic system working for the ring-opening reaction of donor-acceptor cyclopropanes with three different nucleophiles, let alone in an asymmetric version.

  19. Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral N,N'-Dioxide-Scandium(III) Complex.

    PubMed

    Xia, Yong; Lin, Lili; Chang, Fenzhen; Fu, Xuan; Liu, Xiaohua; Feng, Xiaoming

    2015-11-01

    A highly efficient asymmetric ring-opening reaction of cyclopropyl ketones with a broad range of thiols, alcohols and carboxylic acids has been first realized by using a chiral N,N'-dioxide-scandium(III) complex as catalyst. The corresponding sulfides, ethers, and esters were obtained in up to 99% yield and 95% ee. This is also the first example of one catalytic system working for the ring-opening reaction of donor-acceptor cyclopropanes with three different nucleophiles, let alone in an asymmetric version. PMID:26398505

  20. Preservation of condyle and disc in the surgical treatment of type III temporomandibular joint ankylosis: a long-term follow-up clinical study of 111 joints.

    PubMed

    Jakhar, S K; Agarwal, M; Gupta, D K; Tiwari, A D

    2013-06-01

    The purpose of this study was to establish the role of retaining the condyle and disc in the treatment of type III ankylosis, by clinical and computed tomography (CT) evaluation. A total of 90 patients with type III ankylosis met the inclusion criteria; 42 patients had left temporomandibular joint (TMJ) ankylosis, 27 patients had right TMJ ankylosis, and 21 had bilateral TMJ ankylosis, thus a total 111 joints were treated. Considerable improvements in mandibular movement and maximum mouth opening were noted in all patients. At the end of a minimum follow-up of 2 years, the mean inter-incisal mouth opening was 30.7 mm. Postoperative occlusion was normal in all patients, and open bite did not occur in any case because the ramus height was maintained through preservation of the pseudo-joint. Only three patients had recurrence of ankylosis, which was due to a lack of postoperative physiotherapy. The advantages of condyle and disc preservation in type III ankylosis are: (1) surgery is relatively safe; (2) the disc helps to prevent recurrence of ankylosis; (3) the existing ramus height is maintained; (4) the growth site is preserved; and (5) there is no need to reconstruct the joint with autogenous or alloplastic material. It is recommended that the disc and condyle are preserved in type III TMJ ankylosis.

  1. OpenARC: Extensible OpenACC Compiler Framework for Directive-Based Accelerator Programming Study

    SciTech Connect

    Lee, Seyong; Vetter, Jeffrey S

    2014-01-01

    Directive-based, accelerator programming models such as OpenACC have arisen as an alternative solution to program emerging Scalable Heterogeneous Computing (SHC) platforms. However, the increased complexity in the SHC systems incurs several challenges in terms of portability and productivity. This paper presents an open-sourced OpenACC compiler, called OpenARC, which serves as an extensible research framework to address those issues in the directive-based accelerator programming. This paper explains important design strategies and key compiler transformation techniques needed to implement the reference OpenACC compiler. Moreover, this paper demonstrates the efficacy of OpenARC as a research framework for directive-based programming study, by proposing and implementing OpenACC extensions in the OpenARC framework to 1) support hybrid programming of the unified memory and separate memory and 2) exploit architecture-specific features in an abstract manner. Porting thirteen standard OpenACC programs and three extended OpenACC programs to CUDA GPUs shows that OpenARC performs similarly to a commercial OpenACC compiler, while it serves as a high-level research framework.

  2. Immunochemical studies of Lolium perenne (rye grass) pollen allergens, Lol p I, II, and III.

    PubMed

    Ansari, A A; Kihara, T K; Marsh, D G

    1987-12-15

    It was reported earlier that human immune responses to three perennial rye grass (Lolium perenne) pollen allergens, Lol p I, II, and III, are associated with histocompatibility leukocyte antigen (HLA)-DR3. Rye-allergic people are often concordantly sensitive to all three of these allergens. Since earlier studies suggested that these antigens are non-cross-reactive, their immunologic relatedness by double antibody radioimmunoassay (DARIA) was studied in order to understand further the immunochemical basis for the concordant recognition of the three allergens. Direct binding DARIA studies were performed with human sera from 189 allergic subjects. Inhibition DARIA studies were carried out with 17 human sera from grass-allergic patients who were on grass immunotherapy, one goat anti-serum, and six rabbit antisera. None of the sera detected any significant degree of two-way cross-reactivity between Lol p I and II, or between Lol p I and III. However, the degree of two-way cross-reactivity between Lol p II and III exhibited by individual human and animal antisera varied between undetectable and 100%. In general, the degree of cross-reactivity between Lol p II and III was higher among human sera than among animal sera. Taken together with earlier findings that antibody responses to Lol p I, II and III are associated with HLA-HDR3, and that most Lol p II and III responders are also Lol p I responders, but not vice versa, our present results suggest the following: the HLA-DR3-encoded Ia molecule recognizes a similar immunodominant Ia recognition site (agretope) shared between Lol p I and Lol p II and/or III; in addition, Lol p I appears to contain unique Ia recognition site(s) not present in Lol p II and III. However, further epitope analyses are required to investigate these possibilities.

  3. The VPS-20 Subunit of the Endosomal Sorting Complex ESCRT-III Exhibits an Open Conformation in the Absence of Upstream Activation

    PubMed Central

    Schuh, Amber L.; Hanna, Michael; Quinney, Kyle; Wang, Lei; Sarkeshik, Ali; Yates, John R.; Audhya, Anjon

    2015-01-01

    Members of the endosomal sorting complex required for transport (ESCRT) machinery function in membrane remodeling processes during multivesicular endosome biogenesis, cytokinesis, retroviral budding, and plasma membrane repair. During lumenal vesicle formation at endosomes, the ESCRT-II complex and the ESCRT-III subunit VPS-20 play a specific role in regulating assembly of ESCRT-III filaments, which promote vesicle scission. Previous work suggests that Vps20 isoforms, like other ESCRT-III subunits, exhibits an autoinhibited, closed conformation in solution, and its activation depends on an association with ESCRT-II specifically at membranes. However, we show here that C. elegans ESCRT-II and VPS-20 interact directly in solution, both in cytosolic cell extracts and using recombinant proteins in vitro. Moreover, we demonstrate that purified VPS-20 exhibits an open, extended conformation, irrespective of ESCRT-II binding, in contrast with the closed, autoinhibited architecture of another ESCRT-III subunit, VPS-24. Our data argue that individual ESCRT-III subunits adopt distinct conformations, which are tailored for their specific functions during ESCRT-mediated membrane reorganization events. PMID:25588614

  4. The pH dependence of Am(III) complexation with acetate: an EXAFS study.

    PubMed

    Fröhlich, Daniel R; Skerencak-Frech, Andrej; Bauer, Nicole; Rossberg, André; Panak, Petra J

    2015-01-01

    The complexation of acetate with Am(III) is studied as a function of the pH (1-6) by extended X-ray absorption fine-structure (EXAFS) spectroscopy. The molecular structure of the Am(III)-acetate complexes (coordination numbers, oxygen and carbon distances) is determined from the raw k(3)-weighted Am LIII-edge EXAFS spectra. The results show a continuous shift of Am(III) speciation with increasing pH value towards the complexed species. Furthermore, it is verified that acetate coordinates in a bidentate coordination mode to Am(III) (Am-C distance: 2.82 ± 0.03 Å). The EXAFS data are analyzed by iterative transformation factor analysis to further verify the chemical speciation, which is calculated on the basis of thermodynamic constants, and the used structural model. The experimental results are in very good agreement with the thermodynamic modelling. PMID:25537594

  5. A spectrophotometric study of Am(III) complexation with nitrate in aqueous solution at elevated temperatures.

    PubMed

    Tian, Guoxin; Shuh, David K

    2014-10-21

    The complexation of americium(iii) with nitrate was studied at temperatures from 10 to 85 °C in 1 M HNO3-HClO4 by spectrophotometry. The 1 : 1 complex species, AmNO3(2+), was identified and the stability constants were calculated from the absorption spectra recorded for titrations at several temperatures. Specific ion interaction theory (SIT) was used for ionic strength corrections to obtain the stability constants of AmNO3(2+) at infinite dilution and variable temperatures. The absorption spectra of Am(iii) in diluted HClO4 were also reviewed, and the molar absorptivity of Am(iii) at around 503 nm and 813 nm was re-calibrated by titrations with standardized DTPA solutions to determine the concentration of Am(iii). PMID:24999760

  6. Synthesis of Cr(III)-morin complex: characterization and antioxidant study.

    PubMed

    Panhwar, Qadeer K; Memon, Shahabuddin

    2014-01-01

    The complex formation between Cr(III) and morin was carried out in methanol and confirmed by analytical characterization using UV-Vis, IR, (1)H NMR, and TG-DTA. UV-Vis shows significant bathochromic shift in benzoyl upon coordination as well as IR well illustrates the peak shift of C=O group and formation of a O-Cr(III) bond. Likewise, (1)H NMR studies clarify that Cr(III) metal ion replaces the 5OH proton hence; 5-hydroxy-4-keto site is employed by morin in chelation to form six-membered stable ring system out of three available chelating sites. In addition, TG-DTA denotes the presence of coordinated and crystalline water molecules. The melting point of the complex was found to be 389 °C by DSC. In addition, Cr(III)-morin complex was found to be a more potent antioxidant than morin as evaluated by DPPH• and FRAP methods.

  7. X-RAY AND CRYSTALLOGRAPHIC STUDIES OF PLANT VIRUS PREPARATIONS. III.

    PubMed

    Bernal, J D; Fankuchen, I

    1941-09-20

    These papers give an account of an optical and x-ray examination of preparations of plant virus substances isolated by Bawden and Pirie, in particular of those of tobacco mosaic disease. They open with a historical survey of the work, indicating the order in which new phenomena were discovered. The subsequent treatment is divided into three parts: I. Introduction and preparation of specimens. II. Modes of aggregation of virus particles. III. (1) The structure of the particles. (2) Biological implications. Part I, after an historical introduction, describes the method of preparation, from solutions of the virus, of optically oriented specimens of different concentrations. For their examination special x-ray apparatus was developed, in particular cameras working with very low angles and capable of indicating spacings up to 1000 A. In Part III, Section 1 deals with the x-ray evidence on the internal structure of the particles. Even in solution, they have an inner regularity like that of a crystal. Virus preparations are thus in a sense doubly crystalline. Closer analysis reveals that the x-ray patterns are not directly comparable to those of a crystal as many of the reflections do not obey Bragg's law, but can be understood on the theory of gratings of limited size. The structure seems to consist of sub-units of the dimensions of approximately 11 A cube, fitted together in a hexagonal or pseudohexagonal lattice of dimensions-a = 87 A, c = 68 A. Contrary to what earlier observations seemed to indicate, the particle seems to be virtually unchanged by drying and must therefore contain little water. There are marked resemblances with the structure of both crystalline and fibrous protein, but the virus structure does not belong to any of the classes hitherto studied. There are indications that the inner structure is of a simpler character than that of the molecules of crystalline proteins. Part III, Section 2 contains a comparative study of the optical and x

  8. X-RAY AND CRYSTALLOGRAPHIC STUDIES OF PLANT VIRUS PREPARATIONS. III

    PubMed Central

    Bernal, J. D.; Fankuchen, I.

    1941-01-01

    These papers give an account of an optical and x-ray examination of preparations of plant virus substances isolated by Bawden and Pirie, in particular of those of tobacco mosaic disease. They open with a historical survey of the work, indicating the order in which new phenomena were discovered. The subsequent treatment is divided into three parts: I. Introduction and preparation of specimens. II. Modes of aggregation of virus particles. III. (1) The structure of the particles. (2) Biological implications. Part I, after an historical introduction, describes the method of preparation, from solutions of the virus, of optically oriented specimens of different concentrations. For their examination special x-ray apparatus was developed, in particular cameras working with very low angles and capable of indicating spacings up to 1000 Å. In Part III, Section 1 deals with the x-ray evidence on the internal structure of the particles. Even in solution, they have an inner regularity like that of a crystal. Virus preparations are thus in a sense doubly crystalline. Closer analysis reveals that the x-ray patterns are not directly comparable to those of a crystal as many of the reflections do not obey Bragg's law, but can be understood on the theory of gratings of limited size. The structure seems to consist of sub-units of the dimensions of approximately 11 Å cube, fitted together in a hexagonal or pseudohexagonal lattice of dimensions—a = 87 Å, c = 68 Å. Contrary to what earlier observations seemed to indicate, the particle seems to be virtually unchanged by drying and must therefore contain little water. There are marked resemblances with the structure of both crystalline and fibrous protein, but the virus structure does not belong to any of the classes hitherto studied. There are indications that the inner structure is of a simpler character than that of the molecules of crystalline proteins. Part III, Section 2 contains a comparative study of the optical and x

  9. A fluorescence study of tetraphenylporphyrinatozinc(II)/imidazolyl-linked porphyrinatoiron(III) systems

    NASA Astrophysics Data System (ADS)

    Huang, Jin-Wang; Hu, Shu-Guang; Li, Tao; Fan, Li-Fen; Ji, Liang-Nian

    2003-09-01

    The fluorescence spectra of porphyrinatozinc(II)/iron(III) systems which consisted of tetraphenylporphyrinatozinc(II) and three kinds of imidazolyl-linked porphyrinatoiron(III) have been studied. An efficient fluorescence quenching of tetraphenylporphyrinatozinc(II) in the system was observed. Addition of a stronger organic base, such as piperdine, to the system can displace imidazolyl-linked porphyrinatoiron(III) and the fluorescence of the system restored partly. All these indicate the formation of porphyrinatozinc(II)/iron(III) supramolecular complex and coordination bonding formed by the coordination of imidazolyl group in imidazolyl-linked porphyrinatoiron(III) to Zn(II) in tetraphenyl-porphyrinatozinc(II) is the driving force of the supramolecular self-assembly. The association constants of the supramolecular complexes were calculated from the fluorescence spectroscopic titration data, and the differences among the association constants of the supramolecular complexes are discussed on the basis of the conformations which are dependent on the length of alkoxy chain linking imidazolyl group to porphyrinatoiron(III).

  10. Studies in Environment--Volume III: Pollution and the Municipality.

    ERIC Educational Resources Information Center

    Cooper, Pamela C.; And Others

    Recent studies have focused attention on the fact that residents of inner-city neighborhoods are subject to greater amounts of pollutants than are other neighborhoods of large cities. In this study, the premise is set forth and investigated at the metropolitan scale, seeking to discover differences of impact between the center city and its…

  11. Educational Cost Analysis in Action: Case Studies for Planners -- III.

    ERIC Educational Resources Information Center

    Coombs, Philip H.; Hallak, Jacques

    This document is the third in a series of three documents, which together contain 27 case studies on the uses of cost analysis in educational planning. The case studies have been presented to help planners and administrators see how cost analysis can be used to improve the efficiency of their educational systems, and to get the best value from…

  12. Open Access on a Zero Budget: A Case Study of "Postcolonial Text": Case Studies in Open Access Publishing. Number Three

    ERIC Educational Resources Information Center

    Willinsky, John; Mendis, Ranjini

    2007-01-01

    Introduction: The founding of a new open access journal is described in terms of its use of the open source software Open Journal Systems, its contribution to a new field of inquiry and its ability to operate on a zero budget in terms of regular expenses. Method: A case study method is deployed describing the circumstances of the journal's…

  13. Aqueous complexation of citrate with neodymium(III) and americium(III): a study by potentiometry, absorption spectrophotometry, microcalorimetry, and XAFS.

    PubMed

    Brown, M Alex; Kropf, A Jeremy; Paulenova, Alena; Gelis, Artem V

    2014-05-01

    The aqueous complexation of Nd(III) and Am(III) with anions of citrate was studied by potentiometry, absorption spectrophotometry, microcalorimetry, and X-ray absorption fine structure (XAFS). Using potentiometric titration data fitting the metal-ligand (L) complexes that were identified for Nd(III) were NdHL, NdL, NdHL2, and NdL2; a review of trivalent metal-citrate complexes is also included. Stability constants for these complexes were calculated from potentiometric and spectrophotometric titrations. Microcalorimetric results concluded that the entropy term of complex formation is much more dominant than the enthalpy. XAFS results showed a dependence in the Debye-Waller factor that indicated Nd(iii)-citrate complexation over the pH range of 1.56-6.12.

  14. Numerical studies of open ocean deep convection

    NASA Astrophysics Data System (ADS)

    Sander, Johannes; Wolf-Gladrow, Dieter; Olbers, Dirk

    1995-10-01

    Open ocean deep convection is examined with a nonhydrostatic model based on primitive equations. Strong cooling on the surface of the ocean enforces vertical motion which takes place in the narrow regions of convective cells. Different equations of state are considered, and it is shown that a linear equation of state with a constant thermal expansion coefficient cannot represent the buoyancy field and fluxes properly. The inclusion of thermobaric effects leads to additional vertical acceleration in the whole water column. The parametrization of the convective fluxes by a convective adjustment algorithm represents the horizontal mean temperature quite well but suppresses the entire vertical mass transport within the convective cells. This mass transport may be important for the transport of other tracers. Investigation of an energy cycle of the convective motion sorts out sources and sinks and reveals the conversion between different forms of energy during convective events. Both the vertical and the horizontal component of the Earth rotation vector contribute to the time mean energy balance with the same order of magnitude, but the instantaneous amplitudes of the distinct terms may differ substantially. A sensitivity study with respect to eddy and thermal diffusion coefficients distinguishes two regions; at high values of the diffusivities the velocities and tracer distributions show that a strong dependence on this values occurs, while for sufficiently small coefficients, only a weak dependence is observed.

  15. Study on the process of Fe (III) oxide fluorination

    NASA Astrophysics Data System (ADS)

    Sophronov, V. L.; Kalaev, M. E.; Makaseev, Yu N.; Sachkov, V. I.; Verkhoturova, V. V.

    2016-02-01

    The article deals with a fundamentally new fluoride technology for obtaining fluoride materials, provides data on the kinetics of the process of fluorination of Fe oxide with fluorine, fluoride and ammonium bifluoride. The physical and chemical properties of obtained fluorides are shown: a study of the elemental composition, grain-size composition using the method of scanning electron microscopy and laser diffraction.

  16. [Safety evaluation of micronomicin. III. Teratogenicity studies in rats].

    PubMed

    Hara, T; Nishikawa, S; Miyazaki, H; Ohguro, Y

    1983-01-01

    Micronomicin (MCR) is a new aminoglycoside antibiotic produced by Micromonospora sagamiensis var. nonreducans which was isolated from soil collected at Sagamihara by Nara et al. The purified antibiotic showed a close similarity to gentamicin C complex in physical and chemical properties. The antibacterial activity of MCR is broad-spectrum and almost equal to that of gentamicin C complex. MCR exhibits particularly high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc. and high activity against some Pseudomonas aeruginosa strains resistant to gentamicin C1a. Teratogenicity studies of MCR in rats were carried out by intravenous injection for safety evaluation (Dose; 25, 50 mg/kg and 75 mg/kg). The results of studies are as follows. 1. Fetal malformation attributable to MCR was not observed at any dose. 2. Suppression of maternal weight gain was observed at the dose levels of 50 mg/kg and over. 3. There was no adverse effect on new borns at any dose.

  17. Propolis allergy. (III). Sensitization studies with minor constituents.

    PubMed

    Hausen, B M; Wollenweber, E

    1988-10-01

    87% of the propolis product "LB-1", originally reported to be 1,1-dimethyl-allyl caffeic acid ester, was shown by GC/MS analysis to consist of 3 isomeric pentenyl caffeates, 63% of which are 1,1-dimethylallyl caffeate. These pentenyl caffeates proved to be the major sensitizers of propolis and of poplar bud secretion in our previous study. In addition, 3 further minor allergens have now been investigated. Experimental sensitization indicates that phenylethyl caffeate is as strong a sensitizer as the major allergen "LB-1", while benzyl salicylate is a moderate sensitizer. Benzyl cinnamate plays only a subordinate role. At least 3 further esters of caffeic acid or cinnamic acid remain to be studied. Interestingly, relationships between propolis and balsam of Peru were found. 8 compounds are common to both materials. Thus "cross-reactions" or concomitant reactions in propolis-sensitive individuals to balsam of Peru are explainable.

  18. Density functional theory studies of actinide(III) motexafins (An-Motex2+, An = Ac, Cm, Lr). Structure, stability, and comparison with lanthanide(III) motexafins.

    PubMed

    Cao, Xiaoyan; Li, Quansong; Moritz, Anna; Xie, Zhizhong; Dolg, Michael; Chen, Xuebo; Fang, Weihai

    2006-04-17

    Newly developed relativistic energy-consistent 5f-in-core actinide pseudopotentials and corresponding (7s6p5d1f)/[5s4p3d1f] basis sets in the segmented contraction scheme, combined with density functional theory methods, have been used to study the molecular structure and chemical properties of selected actinide(III) motexafins (An-Motex2+, An = Ac, Cm, Lr). Structure and stability are discussed, and a comparison to the lanthanide(III) motexafins (Ln-Motex2+, Ln = La, Gd, Lu) is made. The actinide element is found to reside above the mean N5 motexafin plane, and the larger the cation, the greater the observed out-of-plane displacement. It is concluded that the actinium(III), curium(III), and lawrencium(III) cations are tightly bound to the macrocyclic skeleton, yielding stable structures. However, the calculated metal-ligand gas-phase binding energy for An-Motex2+ is about 1-2 eV lower than that of Ln-Motex2+, implying a lower stability of An-Motex2+ compared to Ln-Motex2+. Results including solvent effects imply that Ac-Motex2+ is the most stable complex in aqueous solution and should be the best candidate for experimentalists to get stable actinide(III) motexafin complexes. PMID:16602805

  19. Complexation of Cm(III) and Eu(III) with CyMe4-BTPhen and CyMe4-BTBP studied by time resolved laser fluorescence spectroscopy.

    PubMed

    Bremer, Antje; Whittaker, Daniel M; Sharrad, Clint A; Geist, Andreas; Panak, Petra J

    2014-02-14

    The complexation of Cm(III) and Eu(III) with 2,9-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-yl)-1,10-phenanthroline (CyMe4-BTPhen) and 6,6'-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-yl)-2,2'-bipyridine (CyMe4-BTBP) in methanolic solution was investigated by TRLFS. For both ligands, the 1:2 complex with the particular metal ion is the only species observed in equilibrated samples. The species distribution for various ligand concentrations was determined and stability constants of the 1:2 complexes were derived (log β2 = 13.8 ± 0.2 (Cm(III)-CyMe4-BTPhen), log β2 = 11.6 ± 0.4 (Eu(III)-CyMe4-BTPhen), log β2 = 12.4 ± 0.3 (Cm(III)-CyMe4-BTBP) and log β2 = 11.3 ± 0.3 (Eu(III)-CyMe4-BTBP)). Biphasic experiments in combination with TRLFS studies on the organic phase revealed the formation of ternary complexes with two CyMe4-BTPhen or -BTBP molecules and additional coordination of a nitrate anion as species formed during the extraction process.

  20. Probing the Natural World, Level III, Teacher's Edition: Environmental Science. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit and its activities focuses on environmental pollution and hazards. Optional excursions are suggested for students who wish to study an area in greater depth. An introduction describes the problem…

  1. Probing the Natural World, Level III, Teacher's Edition: Well-Being. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on hazards to the body from drug use. Activities are given that relate to the topic. Optional excursions are suggested for students who wish to study an area in greater depth. An…

  2. Psychosocial consequences of therapeutic abortion King's termination study III.

    PubMed

    Greer, H S; Lal, S; Lewis, S C; Belsey, E M; Beard, R W

    1976-01-01

    A follow-up study is reported of a consecutive series of 360 women who underwent termination of first trimester pregnancies by vacuum aspiration. Each patient received brief counselling before termination. Follow-up examinations were carried out by means of detailed, structured interviews at three months and between 15 months and two years (mean: 18 months) after termination. Outcome was assessed in terms of psychiatric symptoms, guilt feelings, and adjustment in marital and other interpersonal relationships, sexual responsiveness and work record. Compared with ratings of psychosocial adjustment before termination, significant improvement had occurred at follow-up in respect of psychiatric symptoms, guilt feelings and interpersonal and sexual adjustment; there was no significant change in marital adjustment. Adverse psychiatric and social sequelae were rare.

  3. National police suicide estimates: web surveillance study III.

    PubMed

    O'Hara, Andrew F; Violanti, John M; Levenson, Richard L; Clark, Ronald G

    2013-01-01

    The present study is the third in a series of web surveillance of police suicides (prior analyses conducted in 2008 and 2009). In this age of world web communications, a police suicide in even the smallest and most remote community is generally transmitted nationally and through police websites, forums, and blogs. 55,000 police suicide specific web articles were reviewed over the entire year 2012 data was then compared with 2008 and 2009 police suicide data. There were 141 police suicides in 2008. Suicides declined from 143 in 2009 to 126 in 2012 (an 11.9% decrease). Across the three time periods, male and female suicides appeared to occur at a similar rate, averaging 92% and 6% respectively. In 2012, (1) suicides appeared to cluster more in the 40-44 year age group more than in previous years among officers of lower rank; (2) an increase in suicide was seen among officers with 15-19 years of service; (3) gunshots remained the most prevalent means of suicide across all three years (91.5%), and (4) personal problems appeared to be prevalent (83%) with work associated legal problems ranking second (13%). Approximately 11% of suicides were military veterans. California (n = 10) and New York (n = 12) had the highest police suicide rates. Four murder-suicides were noted over the entire year. Suggestions for suicide preventive policies, improving police mental health, and future research are discussed.

  4. National police suicide estimates: web surveillance study III.

    PubMed

    O'Hara, Andrew F; Violanti, John M; Levenson, Richard L; Clark, Ronald G

    2013-01-01

    The present study is the third in a series of web surveillance of police suicides (prior analyses conducted in 2008 and 2009). In this age of world web communications, a police suicide in even the smallest and most remote community is generally transmitted nationally and through police websites, forums, and blogs. 55,000 police suicide specific web articles were reviewed over the entire year 2012 data was then compared with 2008 and 2009 police suicide data. There were 141 police suicides in 2008. Suicides declined from 143 in 2009 to 126 in 2012 (an 11.9% decrease). Across the three time periods, male and female suicides appeared to occur at a similar rate, averaging 92% and 6% respectively. In 2012, (1) suicides appeared to cluster more in the 40-44 year age group more than in previous years among officers of lower rank; (2) an increase in suicide was seen among officers with 15-19 years of service; (3) gunshots remained the most prevalent means of suicide across all three years (91.5%), and (4) personal problems appeared to be prevalent (83%) with work associated legal problems ranking second (13%). Approximately 11% of suicides were military veterans. California (n = 10) and New York (n = 12) had the highest police suicide rates. Four murder-suicides were noted over the entire year. Suggestions for suicide preventive policies, improving police mental health, and future research are discussed. PMID:24187885

  5. Adsorption of Eu(III) on a heterogeneous surface studied by time-resolved laser fluorescence microscopy (TRLFM).

    PubMed

    Ishida, Keisuke; Kimura, Takaumi; Saito, Takumi; Tanaka, Satoru

    2009-03-15

    Time-resolved laser fluorescence microscopy (TRLFM) is a useful tool to simultaneously investigate the intensity, location, type, and surrounding chemical environment of a fluorophore. In this study, we demonstrated the applicability of TRLFM for the adsorption of Eu(III) on a natural heterogeneous surface. Different adsorption species of Eu(III) were observed on the Makabe granite surface and its constituents (biotite, plagioclase, potassium feldspar, and quartz). Eu(III) heterogeneously adsorbed on biotite, plagioclase, and quartz and homogeneously on potassium feldspar. The histograms of the fluorescence decay rates of adsorbed Eu(III) indicated efficient quenching of Eu(III) fluorescence probably due to Eu(III)-surface interaction or the formation polynuclear hydoxo Eu(III) species on the surfaces. It was also revealed that single species of Eu(III) was observed on biotite and two species on plagioclase and potassium feldspar. The adsorption of Eu(III) on the granite surface was highly heterogeneous. The TRLFM measurements of different regions of the granite surface turned into the finding of Eu(III) with different fluorescence decay rates. Comparing with the fluorescence decay histograms of the mineral constituents, Eu(III) clearly adsorbed on the feldspar family. It was also found that Eu(III) adsorbed as an outer-sphere complex and on an altered mineral of the granite.

  6. The structure of the hydrated gallium(III), indium(III), and chromium(III) ions in aqueous solution. A large angle X-ray scattering and EXAFS study

    SciTech Connect

    Lindqvist-Reis, P.; Pattanaik, S.; Sandstroem, M.; Munoz-Paez, A.; Diaz-Moreno, S.; Persson, I.

    1998-12-28

    The structure of the hydrated gallium(III), indium(III), and chromium(III) ions has been determined in aqueous perchlorate and nitrate solutions by means of the large-angle X-ray scattering (LAXS) and extended X-ray absorption fine structure (EXAFS) techniques. The EXAFS studies have been performed over a wide concentration range, 0.005--1.0 mol/dm{sup 3} (2.6 mol/dm{sup 3} for chromium(III)), while the LAXS studies are restricted to concentrated solutions, ca. 1.5 mol/dm{sup 3}. All three metal ions were found to coordinate six water molecules, each of which are hydrogen bonded to two water molecules in a second hydration sphere. Analyses of the Ga, In, and Cr K-edge EXAFS data of the aqueous perchlorate and nitrate solutions showed no influence on the first shell M{single_bond}O distance by a change of concentration or anion. The minor contribution from the second sphere M{hor_ellipsis}O distance is obscured by multiple scattering within the tightly bonded first shell. EXAFS data for the alum salts CsM(SO{sub 4}){sub 2}{center_dot}12H{sub 2}O, M = Ga or In, showed the M-O bond length of the hexahydrated gallium(III) and indium(III) ions to be 1.957(2) and 2.122(2) {angstrom}, respectively.

  7. Complexation and molecular modeling studies of europium(III)-gallic acid-amino acid complexes.

    PubMed

    Taha, Mohamed; Khan, Imran; Coutinho, João A P

    2016-04-01

    With many metal-based drugs extensively used today in the treatment of cancer, attention has focused on the development of new coordination compounds with antitumor activity with europium(III) complexes recently introduced as novel anticancer drugs. The aim of this work is to design new Eu(III) complexes with gallic acid, an antioxida'nt phenolic compound. Gallic acid was chosen because it shows anticancer activity without harming health cells. As antioxidant, it helps to protect human cells against oxidative damage that implicated in DNA damage, cancer, and accelerated cell aging. In this work, the formation of binary and ternary complexes of Eu(III) with gallic acid, primary ligand, and amino acids alanine, leucine, isoleucine, and tryptophan was studied by glass electrode potentiometry in aqueous solution containing 0.1M NaNO3 at (298.2 ± 0.1) K. Their overall stability constants were evaluated and the concentration distributions of the complex species in solution were calculated. The protonation constants of gallic acid and amino acids were also determined at our experimental conditions and compared with those predicted by using conductor-like screening model for realistic solvation (COSMO-RS) model. The geometries of Eu(III)-gallic acid complexes were characterized by the density functional theory (DFT). The spectroscopic UV-visible and photoluminescence measurements are carried out to confirm the formation of Eu(III)-gallic acid complexes in aqueous solutions.

  8. Synthesis, spectral and electrochemical studies of binuclear Ru(III) complexes containing dithiosemicarbazone ligand

    NASA Astrophysics Data System (ADS)

    Kanchana Devi, A.; Ramesh, R.

    2014-01-01

    Synthesis of several new octahedral binuclear ruthenium(III) complexes of the general composition [(EPh3)2(X)Ru-L-Ru(X)(EPh3)2] containing benzene dithiosemicarbazone ligands (where E = P or As; X = Cl or Br; L = binucleating ligands) is presented. All the complexes have been fully characterized by elemental analysis, FT-IR, UV-vis and EPR spectroscopy together with magnetic susceptibility measurements. IR study shows that the dithiosemicarbazone ligands behave as dianionic tridentate ligands coordinating through the oxygen atom of the deprotonated phenolic group, nitrogen atom of the azomethine group and thiolate sulphur. In DMF solution, all the complexes exhibit intense d-d transition and ligand-to-metal charge transfer (LMCT) transition in the visible region. The magnetic moment values of the complexes are in the range 1.78-1.82 BM, which reveals the presence of one unpaired electron on each metal ion. The EPR spectra of the liquid samples at LNT show the presence of three different 'g' values (gx ≠ gy ≠ gz) indicate a rhombic distortion around the ruthenium ion. All the complexes exhibit two quasi-reversible one electron oxidation responses (RuIII-RuIII/RuIII-RuIV; RuIII-RuIV/RuIV-RuIV) within the E1/2 range of 0.61-0.74 V and 0.93-0.98 V respectively, versus Ag/AgCl.

  9. An EXAFS spectroscopic study of Am(III) complexation with lactate.

    PubMed

    Fröhlich, Daniel R; Skerencak-Frech, Andrej; Kaplan, Ugras; Koke, Carsten; Rossberg, André; Panak, Petra J

    2015-11-01

    The pH dependence (1-7) of Am(III) complexation with lactate in aqueous solution is studied using extended X-ray absorption fine-structure (EXAFS) spectroscopy. Structural data (coordination numbers, Am--O and Am--C distances) of the formed Am(III)-lactate species are determined from the raw k(3)-weighted Am LIII-edge EXAFS spectra. Between pH 1 and pH 6, Am(III) speciation shifts continuously towards complexed species with increasing pH. At higher pH, the amount of complexed species decreases due to formation of hydroxo species. The coordination numbers and distances (3.41-3.43 Å) of the coordinating carbon atoms clearly point out that lactate is bound `side-on' to Am(III) through both the carboxylic and the α-hydroxy function of lactate. The experimentally determined coordination numbers are compared with speciation calculations on the basis of tabulated thermodynamic stability constants. Both EXAFS data and thermodynamic modelling are in very good agreement. The EXAFS spectra are also analyzed by iterative transformation factor analysis to further verify the determined Am(III) speciation and the used structural model. PMID:26524312

  10. Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed

    PubMed Central

    Wilcox, C Mel

    2015-01-01

    Sphincter of Oddi dysfunction (SOD) has been classified into three types based upon the presence or absence of objective findings including liver test abnormalities and bile duct dilatation. Type III is the most controversial and is classified as biliary type pain in the absence of any these objective findings. Many prior studies have shown that the clinical response to endoscopic therapy is higher based upon the presence of these objective criteria. However, there has been variable correlation of the manometry findings to outcome after endoscopic therapy. Nevertheless, manometry and sphincterotomy has been recommended for Type III patients given the overall response rate of 33%, although the reported response rates are highly variable. However, all of the prior data was non-blinded and non-randomized with variable follow-up. The evaluating predictors in SOD study - a prospective randomized blinded sham controlled one year outcome study showed no correlation between manometric findings and outcome after sphincterotomy. Furthermore, patients receiving sham therapy had a statistically significantly better outcome than those undergoing biliary or dual sphincterotomy. This study calls into question the whole concept of SOD Type III and, based upon prior physiologic studies, one can suggest that SOD Type III likely represents a right upper quadrant functional abdominal pain syndrome and should be treated as such. PMID:26019439

  11. Spectroscopic studies on gallic acid and its azo derivatives and their iron(III) complexes.

    PubMed

    Masoud, Mamdouh S; Ali, Alaa E; Haggag, Sawsan S; Nasr, Nessma M

    2014-01-01

    Azo gallic derivatives and their iron(III) complexes were synthesized and characterized. The stereochemistry and the mode of bonding of the complexes were achieved based on elemental analysis, UV-Vis and IR. The thermal behaviors of the complexes were studied. The effect of pH on the electronic absorption spectra of gallic acid and its azo derivatives are discussed. Different spectroscopic methods (molar ratio, straight line method, continuous variation, slope ratio and successive method) are applied for determination of stoichiometry and pK values for the complex formation of gallic acid with iron(III) in aqueous media. Iron(III) complexes of gallic acid is formed with different ratio: 1:1, 1:2, 1:3 and 1:4 (M:L).

  12. Potential of Agave lechuguilla biomass for Cr(III) removal from aqueous solutions: thermodynamic studies.

    PubMed

    Romero-González, J; Peralta-Videa, J R; Rodríguez, E; Delgado, M; Gardea-Torresdey, J L

    2006-01-01

    Thermodynamic studies on the bioadsorption of Cr(III) onto Agave lechuguilla biomass were conduced. The experimental results at different temperatures were modeled using the Langmuir and Freundlich isotherms to obtain the characteristic parameters of each model. Both the Freundlich and Langmuir models were found to represent the bioadsorption process. The average adsorption capacities calculated from Freundlich (4.7 mg/g) and Langmuir (14.2 mg/g) isotherms showed A. lechuguilla to be an effective biomass in the removal of Cr(III) from an aqueous solution. Thermodynamic parameters (deltaG0, deltaH0 and deltaS0) determined in the temperature range from 10 to 40 degrees C along with the parameters of the Dubinin-Radushkevick equation support the idea that the binding of Cr(III) may be caused by interactions with functional groups such as carboxyl groups located on the outer surface of the cell tissue of the bioadsorbent. PMID:16154514

  13. [Advances in studies of the type III secretion system in Ralstonia solanacearum--A review].

    PubMed

    Zhang, Yong; Li, Muyuan; Luo, Feng

    2015-06-01

    Bacterial wilt caused by Ralstonia solanacearum is one of the most devastating plant diseases worldwide. The syringe-like type III secretion system (T3SS) plays a crucial role in its pathogenicity. R. solanacearum uses the T3SS to inject effector proteins (Type III effectors) into the cytoplasm of host cells, causing diseases in susceptible plants or triggering the hypersensitive response in resistant plants. In this article we review recent advances in studies of R. solanacearum T3SS and highlight their unique features. PMID:26562991

  14. [Advances in studies of the type III secretion system in Ralstonia solanacearum--A review].

    PubMed

    Zhang, Yong; Li, Muyuan; Luo, Feng

    2015-06-01

    Bacterial wilt caused by Ralstonia solanacearum is one of the most devastating plant diseases worldwide. The syringe-like type III secretion system (T3SS) plays a crucial role in its pathogenicity. R. solanacearum uses the T3SS to inject effector proteins (Type III effectors) into the cytoplasm of host cells, causing diseases in susceptible plants or triggering the hypersensitive response in resistant plants. In this article we review recent advances in studies of R. solanacearum T3SS and highlight their unique features.

  15. Probing the Natural World, Level III, Student Guide: Winds and Weather. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's text of one of the units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). The chapters contain basic information about weather, its measurement and predictions, activities related to the subject, and optional excursions. A section of introductory notes to the student discusses how to use…

  16. Social Studies Course III. India: A Cultural Area. Teacher's Manual and Readings.

    ERIC Educational Resources Information Center

    Leppert, Ella C.

    This secondary level instructional unit on India is the second of three cultural areas comprising Course III, "Cultural Areas of Today's World," and follows the first sequential social studies unit on Africa described in SO 003 516. A major objective is for the student to comprehend the characteristics and value structure of India and, more…

  17. Report on "A" Testing. Beginning Teacher Evaluation Study. Technical Note Series. Technical Note III-2.

    ERIC Educational Resources Information Center

    Cahen, Leonard S.

    The "A" testing program of the Beginning Teacher Evaluation Study, Phase III-B, is summarized. A sample of 150 second grade and 134 fifth grade students completed the reading and mathematics achievement battery, as well as affective scales regarding reading, mathematics, and school. The administration procedures, test results, and psychometric…

  18. Report of "B" Testing. Beginning Teacher Evaluation Study. Technical Note Series. Technical Note III-3.

    ERIC Educational Resources Information Center

    Cahen, Leonard S.

    The "B" testing program of the Beginning Teacher Evaluation Study, Phase III-B, is summarized. A sample of 146 second grade and 128 fifth grade students completed the reading and mathematics achievement battery, as well as affective scales pertaining to reading, mathematics, and school. The administration procedures, test results, and psychometric…

  19. Probing the Natural World, Level III, Student Guide: Environmental Science. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's edition of one of the Intermediate Science Curriculum Study (ISCS) units for level III students (grade 9). The chapters contain basic information about environmental pollution and hazards, activities related to the subject, and optional excursions. A section on introductory notes to the student discusses how to use the book…

  20. Probing the Natural World, Level III, Student Guide: In Orbit. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's text of one unit of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on the properties of sunlight, the use of spectrums and spectroscopes, the heat and energy of the sun, the measurement of astronomical distances, and the size of the sun. Activities are student-centered and…

  1. Probing the Natural World, Level III, Teacher's Edition: In Orbit. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on the properties of sunlight, the use of spectrums and spectroscopes, the heat and energy of the sun, the measurement of astronomical distances, and the size of the sun. Optimal…

  2. Civilization III and Whole-Class Play in High School Social Studies

    ERIC Educational Resources Information Center

    Lee, John K.; Probert, Jeffrey

    2010-01-01

    This study examined an 11th grade high school class as they played the game Civilization III. Over nine class sessions students played the game in support of other activities related to several predetermined and emergent topics in U. S. history. Gameplay was whole-class oriented and involved students taking turns at the computer controlling…

  3. LABORATORY STUDY ON THE OXIDATION OF ARSENIC III TO ARSENIC V

    EPA Science Inventory

    A one-year laboratory study was performed to determine the ability of seven oxidants to oxidize As(III) to As(V). These included chlorine, permanganate, ozone, chlorine dioxide, monochloramine, a solid-phase oxidizing media, and 254 nm ultraviolet light. Chlorine and permanganate...

  4. Perturbation of Maize Phenylpropanoid Metabolism by an AvrE Family Type III Effector from Pantoea stewartii1[OPEN

    PubMed Central

    Asselin, Jo Ann E.; Lin, Jinshan; Perez-Quintero, Alvaro L.; Gentzel, Irene; Majerczak, Doris; Opiyo, Stephen O.; Zhao, Wanying; Paek, Seung-Mann; Kim, Min Gab; Coplin, David L.; Blakeslee, Joshua J.; Mackey, David

    2015-01-01

    AvrE family type III effector proteins share the ability to suppress host defenses, induce disease-associated cell death, and promote bacterial growth. However, despite widespread contributions to numerous bacterial diseases in agriculturally important plants, the mode of action of these effectors remains largely unknown. WtsE is an AvrE family member required for the ability of Pantoea stewartii ssp. stewartii (Pnss) to proliferate efficiently and cause wilt and leaf blight symptoms in maize (Zea mays) plants. Notably, when WtsE is delivered by a heterologous system into the leaf cells of susceptible maize seedlings, it alone produces water-soaked disease symptoms reminiscent of those produced by Pnss. Thus, WtsE is a pathogenicity and virulence factor in maize, and an Escherichia coli heterologous delivery system can be used to study the activity of WtsE in isolation from other factors produced by Pnss. Transcriptional profiling of maize revealed the effects of WtsE, including induction of genes involved in secondary metabolism and suppression of genes involved in photosynthesis. Targeted metabolite quantification revealed that WtsE perturbs maize metabolism, including the induction of coumaroyl tyramine. The ability of mutant WtsE derivatives to elicit transcriptional and metabolic changes in susceptible maize seedlings correlated with their ability to promote disease. Furthermore, chemical inhibitors that block metabolic flux into the phenylpropanoid pathways targeted by WtsE also disrupted the pathogenicity and virulence activity of WtsE. While numerous metabolites produced downstream of the shikimate pathway are known to promote plant defense, our results indicate that misregulated induction of phenylpropanoid metabolism also can be used to promote pathogen virulence. PMID:25635112

  5. Systematic Study of a Family of Butterfly-Like {M2Ln2} Molecular Magnets (M = Mg(II), Mn(III), Co(II), Ni(II), and Cu(II); Ln = Y(III), Gd(III), Tb(III), Dy(III), Ho(III), and Er(III)).

    PubMed

    Moreno Pineda, Eufemio; Chilton, Nicholas F; Tuna, Floriana; Winpenny, Richard E P; McInnes, Eric J L

    2015-06-15

    A family of 3d-4f [M(II)2Ln(III)2(μ3-OH)2(O2C(t)Bu)10](2-) "butterflies" (where M(II) = Mg, Co, Ni, and Cu; Ln(III) = Y, Gd, Tb, Dy, Ho, and Er) and [Mn(III)2Ln(III)2(μ3-O)2(O2C(t)Bu)10](2-) molecules (where Ln(III) = Y, Gd, Tb, Dy, Ho, and Er) has been synthesized and characterized through single-crystal X-ray diffraction, SQUID magnetometry, and ab initio calculations. All dysprosium- and some erbium-containing tetramers showed frequency-dependent maxima in the out-of-phase component of the susceptibility associated with slow relaxation of magnetization, and hence, they are single-molecule magnets (SMMs). AC susceptibility measurements have shown that the SMM behavior is entirely intrinsic to the Dy and Er sites and the magnitude of the energy barrier is influenced by the interactions between the 4f and the 3d metal. A trend is observed between the strength of the 3d-4f exchange interaction between and the maximum observed in the χ″M(T). PMID:26016421

  6. Star formation in Chamaeleon I and III: a molecular line study of the starless core population

    NASA Astrophysics Data System (ADS)

    Tsitali, A. E.; Belloche, A.; Garrod, R. T.; Parise, B.; Menten, K. M.

    2015-03-01

    Context. The Chamaeleon dark molecular clouds are excellent nearby targets for low-mass star formation studies. Even though they belong to the same cloud complex, Cha I and II are actively forming stars while Cha III shows no sign of ongoing star formation. Aims: We aim to determine the driving factors that have led to the very different levels of star formation activity in Cha I and III and examine the dynamical state and possible evolution of the starless cores within them. Methods: Observations were performed in various molecular transitions with the APEX and Mopra telescopes. We examine the kinematics of the starless cores in the clouds through a virial analysis, a search for contraction motions, and velocity gradients. The chemical differences in the two clouds are explored through their fractional molecular abundances, derived from a non-LTE analysis, and comparison to predictions of chemical models. Results: Five cores are gravitationally bound in Cha I and one in Cha III. The so-called infall signature indicating contraction motions is seen toward 8-17 cores in Cha I and 2-5 cores in Cha III, which leads to a range of 13-28% of the cores in Cha I and 10-25% of the cores in Cha III that are contracting and may become prestellar. There is no significant difference in the turbulence level in the two clouds. Future dynamical interactions between the cores will not be dynamically significant in either Cha I or III, but the subregion Cha I North may experience collisions between cores within ~0.7 Myr. Turbulence dissipation in the cores of both clouds is seen in the high-density tracers N2H+ 1-0 and HC3N 10-9 which have lower non-thermal velocity dispersions compared to C17O 2-1, C18O 2-1, and C34S 2-1. Evidence of depletion in the Cha I core interiors is seen in the abundance distributions of the latter three molecules. The median fractional abundance of C18O is lower in Cha III than Cha I by a factor of ~2. The median abundances of most molecules (except

  7. Closed cycle versus open cycle gas turbines. A review of A. D. Little's ICOP report, Vol. III

    SciTech Connect

    Not Available

    1984-08-24

    This report addresses the question how coal fired closed cycle gas turbine cogenerators perform economically in comparison to coal fired open cycle gas turbine configurations. The return on equity (ROE) was selected as a measure of economic performance. The investigations determined attainable ROE's for three industries (Agrichemical Products, Brewery, Kraft Paper Mill) for closed and open configurations as proposed in a report on the Industrial Cogeneration Optimization Program. Life cycle analyses were conducted assessing this impact of various parameters upon the rankordering of ROE's for the four topping configurations (one closed cycle, three open cycle gas turbines).

  8. Oxidative study of gabapentin by alkaline hexacyanoferrate(III) in room temperature in presence of catalytic amount of Ru(III) a mechanistic approach

    NASA Astrophysics Data System (ADS)

    Jose, Timy P.; Angadi, Mahantesh A.; Salunke, Manjalee S.; Tuwar, Suresh M.

    2008-12-01

    The kinetics of oxidation of gabapentin by hexacyanoferrate(III) in aqueous alkaline medium at a constant ionic strength of 0.5 mol dm -3 was studied spectrophotometrically. The reaction is of first order in [HCF(III)] and of less than unit order in [alkali]. The reaction rate is independent upon [gabapentin]. Effects of added products, ionic strength and dielectric constant of the reaction medium have been investigated. Oxidative product of gabapentin was identified. A suitable mechanism has been proposed. The reaction constants involved in the different steps of mechanism are calculated. The activation parameters of the mechanism are computed and discussed .

  9. Magnetic susceptibility of actinide(iii) cations: an experimental and theoretical study.

    PubMed

    Autillo, Matthieu; Guerin, Laetitia; Bolvin, Hélène; Moisy, Philippe; Berthon, Claude

    2016-03-01

    In a previous paper, the influence of radioactive decay (α and β(-)) on magnetic susceptibility measurements by the Evans method has been demonstrated by the study of two americium isotopes. To characterize more accurately this phenomenon and particularly its influence on the Curie law, a new study has been performed on two uranium isotopes ((238)U and (233)U) and on tritiated water ((3)H2O). The results on the influence of α emissions have established a relationship between changes in the temperature dependence and the radioactivity in solution. Regarding the β(-) emissions, less influence was observed while no temperature dependence linked to this kind of radioactive emission could be identified. Once magnetic susceptibility measurements of actinide(iii) cations were corrected from radioactivity effects, methods of quantum chemistry have been used on free ions and aquo complexes to calculate the electronic structure explaining the magnetic properties of Pu(iii), Am(iii) and Cm(iii). The ligand field effect on the magnetic behavior (the Curie constant and temperature-independent susceptibilities) was analyzed by considering different solvation environments. PMID:26864302

  10. The Arabidopsis Endosomal Sorting Complex Required for Transport III Regulates Internal Vesicle Formation of the Prevacuolar Compartment and Is Required for Plant Development1[C][W][OPEN

    PubMed Central

    Cai, Yi; Zhuang, Xiaohong; Gao, Caiji; Wang, Xiangfeng; Jiang, Liwen

    2014-01-01

    We have established an efficient transient expression system with several vacuolar reporters to study the roles of endosomal sorting complex required for transport (ESCRT)-III subunits in regulating the formation of intraluminal vesicles of prevacuolar compartments (PVCs)/multivesicular bodies (MVBs) in plant cells. By measuring the distributions of reporters on/within the membrane of PVC/MVB or tonoplast, we have identified dominant negative mutants of ESCRT-III subunits that affect membrane protein degradation from both secretory and endocytic pathways. In addition, induced expression of these mutants resulted in reduction in luminal vesicles of PVC/MVB, along with increased detection of membrane-attaching vesicles inside the PVC/MVB. Transgenic Arabidopsis (Arabidopsis thaliana) plants with induced expression of ESCRT-III dominant negative mutants also displayed severe cotyledon developmental defects with reduced cell size, loss of the central vacuole, and abnormal chloroplast development in mesophyll cells, pointing out an essential role of the ESCRT-III complex in postembryonic development in plants. Finally, membrane dissociation of ESCRT-III components is important for their biological functions and is regulated by direct interaction among Vacuolar Protein Sorting-Associated Protein20-1 (VPS20.1), Sucrose Nonfermenting7-1, VPS2.1, and the adenosine triphosphatase VPS4/SUPPRESSOR OF K+ TRANSPORT GROWTH DEFECT1. PMID:24812106

  11. Synthesis of Cr(III)-Morin Complex: Characterization and Antioxidant Study

    PubMed Central

    Panhwar, Qadeer K.; Memon, Shahabuddin

    2014-01-01

    The complex formation between Cr(III) and morin was carried out in methanol and confirmed by analytical characterization using UV-Vis, IR, 1H NMR, and TG-DTA. UV-Vis shows significant bathochromic shift in benzoyl upon coordination as well as IR well illustrates the peak shift of C=O group and formation of a O–Cr(III) bond. Likewise, 1H NMR studies clarify that Cr(III) metal ion replaces the 5OH proton hence; 5-hydroxy-4-keto site is employed by morin in chelation to form six-membered stable ring system out of three available chelating sites. In addition, TG-DTA denotes the presence of coordinated and crystalline water molecules. The melting point of the complex was found to be 389°C by DSC. In addition, Cr(III)-morin complex was found to be a more potent antioxidant than morin as evaluated by DPPH• and FRAP methods. PMID:24688439

  12. Performance of APACHE III over time in Australia and New Zealand: a retrospective cohort study.

    PubMed

    Paul, E; Bailey, M; Van Lint, A; Pilcher, V

    2012-11-01

    The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model has been used for benchmarking intensive care unit (ICU) outcomes in Australia and New Zealand for over a decade. This study assessed performance of the APACHE III-j model in adult patients admitted to Australasian ICUs during a ten-year period. Data were extracted from the Australian and New Zealand Intensive Care Society Adult Patient Database. Performance of APACHE III-j at different time points and within different age strata was evaluated by dividing the whole cohort into five 'two-year' groups. Calibration and discrimination were assessed by the Brier score, Hosmer-Lemeshow C and H statistics, Standardised Mortality Ratio (SMR), Cox calibration regression, calibration curves and area under the receiver operating characteristic curve (AUROC). Model performance within diagnostic categories was evaluated. Between 1 January 2000 and 31 December 2009, 558,585 ICU admissions which met inclusion criteria were included in the analysis. The mean (standard deviation) age was 60.8 (18.4) years and 58.3% were male. Overall observed mortality was 12.6%. The mean (standard deviation) APACHE III-j predicted mortality was 14.5% (21.8). Although discrimination (as measured by AUROC) was preserved over time, all other markers of model performance showed deterioration. There was a significant decrease in SMR in eight of ten most common diagnoses examined. This study demonstrates that performance of APACHE III-j model has deteriorated in Australasian hospitals and there is now a clear need for an updated modelling approach to improve mortality prediction, performance monitoring and quality of research undertaken in Australian and New Zealand ICUs.

  13. Colloidal α-Al2O3 Europium(III) and humic substances interactions: a macroscopic and spectroscopic study.

    PubMed

    Janot, Noémie; Benedetti, Marc F; Reiller, Pascal E

    2011-04-15

    Eu(III) sorption onto α-Al(2)O(3) in the presence of purified Aldrich humic acid (PAHA) is studied by batch experiments and time-resolved laser-induced luminescence spectroscopy of Eu(III). Experiments are conducted at varying pH, at 0.1 mol/L NaClO(4), 10(-6) mol/L Eu(III), 1 g/L α-Al(2)O(3) and 28 mg/L PAHA, which assured a complete Eu(III)-PAHA complexation. Adsorption of Eu(III) presents the expected pH-edge at 7, which is modified by addition of PAHA. Presence of Eu(III) slightly increases PAHA sorption throughout the pH range. The evolutions of luminescence spectra and decay times of the binary systems, that is, Eu(III)/α-Al(2)O(3) and Eu(III)/PAHA, indicate a progressive surface- and humic-complexation with increasing pH. The typical biexponential luminescence decay in Eu(III)/PAHA system is also recorded; the fastest deactivation depending barely on pH. In ternary Eu(III)/PAHA/α-Al(2)O(3) system, the existence of a luminescence biexponential decay for all pH means that Eu(III) is always in the direct neighborhood of the humic substance. Below pH 7, the spectra of the ternary system (Eu(III)/PAHA/α-Al(2)O(3)) are not different from the ones of Eu(III)/PAHA system, implying the same complex symmetry. Nevertheless, the increase of luminescence decay time points to a change in PAHA conformation onto the surface.

  14. Preparation, spectroscopic and thermal characterization of new La(III), Ce(III), Sm(III) and Y(III) complexes of enalapril maleate drug. In vitro antimicrobial assessment studies

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Al-Azab, Fathi M.; Al-Maydama, Hussein M. A.; Amin, Ragab R.; Jamil, Yasmin M. S.

    2014-02-01

    The 1:1 M ratio metal complexes of enalapril maleate hypertensive drug with La(III), Ce(III), Sm(III) and Y(III) were synthesized. The suggested structures of the resulted complexes based on the results of elemental analyses, molar conductivity, (infrared, UV-visible and fluorescence) spectra, effective magnetic moment, thermal analysis (TG), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) were discussed. The infrared spectral data were suggested that enalapril reacts with metal ions as an ionic bidentate ligand through its carboxylate oxygen and the amide carbonyl oxygen, but in case of the Sm(III) complex, it reacted as a monodentate through its amide carbonyl oxygen. Maleate moiety acts with all these metals as bidentate ligand through its carboxylate or carbonyl oxygen. The kinetic and thermodynamic parameters such as: Ea, ΔH*, ΔS* and ΔG* were estimated from the DTG curves. The antibacterial evaluation of the enalapril maleate and their complexes were also performed against some gram positive and negative bacteria as well as fungi.

  15. Illinois Natural Heritage Conservation/Education Kit III. Special Theme: Prairie and Open Habitats Ecology and Management.

    ERIC Educational Resources Information Center

    Stone, Sally F.

    This instructional guide contains 15 activities and exercises designed to help teachers familiarize their students with prairie and open habitat resources of Illinois. Each activity or exercise is ready to be copied and given to students. Activities include: (1) making a marsh hawk model; (2) building a prairie ecosystem; (3) investigating food…

  16. Bismuth(III) trifluoromethanesulfonate catalyzed ring opening reaction of mono epoxy oleochemicals to form keto and diketo derivatives

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Using a catalytic system, methyl oleate is transformed into long chain keto and diketo derivatives via an epoxide route. Methyl 9(10)-oxooctadecanoate and methyl 9,10-dioxooctadecanoate were made by a ring opening reaction of epoxidized methyl oleate using bismuth triflate catalyst. Lower reaction t...

  17. Studies of the III-V compounds in the megabar regime. Technical progress report

    SciTech Connect

    Ruoff, A.L.

    1992-09-01

    In this project we develop techniques for making high pressure measurements (x-ray diffraction and optical measurements) on samples in the multimegabar regime and we make systematic studies of the crystal structure of III-V compounds and other materials as a function of pressure with the broad objective of providing experimental data over a broad range of coordination number and interatomic spacing which can play a leading role in the testing and development of theoretical models of binding.

  18. Complexation Studies of Bidentate Heterocyclic N-Donor Ligands with Nd(III) and Am(III)

    SciTech Connect

    Ogden, Mark; Hoch, Courtney L.; Sinkov, Sergey I.; Meier, Patrick; Lumetta, Gregg J.; Nash, Kenneth L.

    2011-11-28

    A new bidentate nitrogen donor complexing agent that combines pyridine and triazole functional groups, 2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)pyridine (PTMP), has been synthesized. The strength of its complexes with trivalent americium (Am3+) and neodymium (Nd3+) in anhydrous methanol has been evaluated using spectrophotometric techniques. The purpose of this investigation is to assess this ligand (as representative of a class of similarly structured species) as a possible model compound for the challenging separation of trivalent actinides from lanthanides. This separation, important in the development of advanced nuclear fuel cycles, is best achieved through the agency of multidentate chelating agents containing some number of nitrogen or sulfur donor groups. To evaluate the relative strength of the bidentate complexes, the derived constants are compared to those of the same metal ions with 2,2*-bipyridyl (bipy), 1,10-phenanthroline (phen), and 2-pyridin-2-yl-1H-benzimidazole (PBIm). At issue is the relative affinity of the triazole moiety for trivalent f element ions. For all ligands, the derived stability constants are higher for Am3+ than Nd3+. In the case of Am3+ complexes with phen and PBIm, the presence of 1:2 (AmL2) species is indicated. Possible separations are suggested based on the relative stability and stoichiometry of the Am3+ and Nd3+ complexes. It can be noted that the 1,2,3-triazolyl group imparts a potentially useful selectivity for trivalent actinides (An(III)) over trivalent lanthanides (Ln(III)), though the attainment of higher complex stoichiometries in actinide compared with lanthanide complexes may be an important driver for developing successful separations.

  19. The death of a mind: a study of Shakespeare's Richard III.

    PubMed

    Anderson, Maxine K

    2006-11-01

    Some of the most difficult aspects of our work involve our encounters with states of mind which are steeped in and spread violence. In these circumstances, we experience our best efforts to offer empathic presence and thought to avoid being assaulted and obliterated. In these instances, a figure from literature depicting the details in question may come to our aid. In the play popularly known as Richard III,William Shakespeare depicts how the state of mind which is etched by grievance and committed to revenge may impose the 'winter of (its) discontent' upon the sunny dispositions of others' healthy, integrated functioning. Shakespeare masterfully depicts Richard's cunning and malice, but he also illustrates how this vengeful state uses guile and 'changes of shape' to seduce its way past protective boundaries, utilizing the human qualities of trust, open-heartedness and longing as pathways for invasion, betrayal and emotional devastation. This paper will view excerpts of the play's text from a psychoanalytic perspective which suggests that several clear lessons about this obliterative state of mind may be gleaned: that grievance can only operate to spread grievance and destruction; that our open-hearted and trusting qualities do make us vulnerable to such invasion and betrayal, but that our humanity is also the only avenue for rescue from this plight. In addition a clear lesson is offered about the value of protected 'sanctuary', that is, mental space where our most potent tool in these circumstances, our discerning minds, might find residence. PMID:17064337

  20. Axial Imidazole Binding Strengths in Porphyrinoid Cobalt(III) Complexes as Studied by Tandem Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Mishra, Ekta; Worlinsky, Jill L.; Gilbert, Thomas M.; Brückner, Christian; Ryzhov, Victor

    2012-06-01

    The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) in conjunction with the energy-variable collision-induced dissociation (CID) technique was used to compare the relative gas-phase binding strength of the axially coordinated imidazoles to the octahedral and square planar Co(III) porphyrinoid complex ions. The observed binding energies of these ligands were rationalized in terms of the effects of porphyrinoid core structure and meso-substitution on the electron density on the central Co(III) centers. Some of these trends were supported by DFT-based computational studies. The study highlights to which extend porphyrins vary from chlorins and chlorin analogues in their coordination abilities and to which extraordinary degree meso-thienyl-substituents influence the electronic structure of porphyrins. The study also defines further the scope and limits CID experiments can be used to interrogate the electronic structures of metalloporphyrin complexes.

  1. Infection by bacterial pathogens expressing type III secretion decreases luciferase activity: ramifications for reporter gene studies.

    PubMed

    Savkovic, S D; Koutsouris, A; Wu, G; Hecht, G

    2000-09-01

    Pathogenic microbes influence gene regulation in eukaryotic hosts. Reporter gene studies can define the roles of promoter regulatory sequences. The effect of pathogenic bacteria on reporter genes has not been examined. The aim of this study was to identify which reporter genes are reliable in studies concerning host gene regulation by bacterial pathogens expressing type III secretory systems. Human intestinal epithelial cells, T84, Caco-2 and HT-29, were transfected with plasmids containing luciferase (luc), chloramphenicol acetyltransferase (CAT) or beta-galactosidase (beta-gal) as reporter genes driven by the inducible interleukin-8 (IL-8) or constitutively active simian virus 40 (SV40) promoter. Cells were infected with enteropathogenic E. coli or Salmonella typhimurium, and the reporter activity was assessed. Luc activity significantly decreased following infection, regardless of the promoter. The activity of recombinant luc was nearly ablated by incubation with either EPEC or Salmonella in a cell-free system. Activity was partially preserved by protease inhibitors, and immunoblot analysis showed a decreased amount and molecular weight of recombinant luc, suggesting protein degradation. Neither beta-gal nor CAT activity was altered by infection. Disruption of type III secretion prevented the loss of luc activity. We conclude that CAT or beta-gal, but not luc, can be used as reliable reporter genes to assess the impact of pathogenic microbes, especially those expressing type III secretion on host cell gene regulation.

  2. NGC 7789: An open cluster case study

    SciTech Connect

    Overbeek, Jamie C.; Friel, Eileen D.; Pilachowski, Catherine A.; Mészáros, Szabolcs; Jacobson, Heather R.; Johnson, Christian I.

    2015-01-01

    We have obtained high-resolution spectra of 32 giants in the open cluster NGC 7789 using the Wisconsin–Indiana–Yale–NOAO Hydra spectrograph. We explore differences in atmospheric parameters and elemental abundances caused by the use of the linelist developed for the Gaia-ESO Survey (GES) compared to one based on Arcturus used in our previous work. [Fe/H] values decrease when using the GES linelist instead of the Arcturus-based linelist; these differences are probably driven by systematically lower (∼−0.1 dex) GES surface gravities. Using the GES linelist we determine abundances for 10 elements—Fe, Mg, Si, Ca, Ti, Na, Ni, Zr, Ba, and La. We find the cluster's average metallicity [Fe/H] = 0.03 ± 0.07 dex, in good agreement with literature values, and a lower [Mg/Fe] abundance than has been reported before for this cluster (0.11 ± 0.05 dex). We also find the neutron-capture element barium to be highly enhanced—[Ba/Fe] = +0.48 ± 0.08—and disparate from cluster measurements of neutron-capture elements La and Zr (−0.08 ± 0.05 and 0.08 ± 0.08, respectively). This is in accordance with recent discoveries of supersolar Ba enhancement in young clusters along with more modest enhancement of other neutron-capture elements formed in similar environments.

  3. Synthesis, characterization and antibacterial study of cyclometalated rhodium(III) complex containing dithiocarbamate

    NASA Astrophysics Data System (ADS)

    Mansouri, Ghobad; Heidarizadi, Fateme; Naghipour, Ali; Notash, Behrouz

    2016-10-01

    The novel cyclometalated Rh(III) complex, [Rh(phpy)2(SˆS)], Where phpy is 2-phenylpyridine and (SˆS) is diethyldithiocarbamate, has been prepared and characterized by elemental analysis, IR, 13C and 1H NMR, electronic absorption and Fluorescence spectroscopies, cyclic voltammetry, and X-ray crystallography. The crystal structure of [Rh(phpy)2(SˆS)] shows that the coordination geometry around the Rh(III) is a distorted octahedron, with bite angles of 71.19-81.04° for all three bidentate ligands. Electrochemical analysis by cyclic voltammetry reveals irreversible redox behavior of the rhodium centre. Antibacterial activity of the complex has also been studied by agar disc diffusion method against three Gram-negative bacteria (Pseudomonas aeroginosa, Salmonella typhi and Escherichia coli) and two Gram-positive bacteria (Staphylococcus aureus and Corynebacterium renale).

  4. X-ray diffraction, FTIR, UV-VIS and SEM studies on chromium (III) complexes

    SciTech Connect

    Mishra, Ashutosh; Dwivedi, Jagrati Shukla, Kritika

    2015-06-24

    Five Chromium (III) complexes have been prepared using Schiff base ligands which derived from benzoin and five different amino acids (H{sub 2}N-R). Samples were characterized by XRD, FTIR, UV-VIS and SEM method. X-Ray diffraction pattern analyzed that all chromium (III) complexes have hexagonal structure and crystalline, in nature, using Bruker D8 Advance instrument. Using VERTAX 70, FTIR spectroscopy reveals that Samples have (C=N), (C-O), (M-N) and (M-O) bonds in the range of 4000-400cm{sup −1}. UV-VIS spectroscopy give information that samples absorb the visible light which is in the range of 380-780nm. For this, Lambda 960 spectrometer used. SEM is designed for studying of the solid objects, using JEOL JSM 5600 instrument.

  5. Mononuclear Ru(III) Schiff base complexes: Synthesis, spectral, redox, catalytic and biological activity studies

    NASA Astrophysics Data System (ADS)

    Priya, N. Padma; Arunachalam, S.; Manimaran, A.; Muthupriya, D.; Jayabalakrishnan, C.

    2009-04-01

    An octahedral ruthenium(III) Schiff base complexes of the type [RuX(EPh 3)(L)] (where, X = Cl/Br; E = As/P; L = dianion of the Schiff bases derived from acetoacetanilide with o-phenylenediamine and salicylaldehyde/ o-hydroxyacetophenone/ o-vanillin/2-hydroxy-1-naphthaldehyde) have been synthesized from the reactions of equimolar reactions of [RuX 3(EPh 3) 3] and Schiff bases in benzene. The new Ru(III) Schiff base complexes have been characterized by elemental analyses, FT-IR, electronic, 1H NMR and 13C NMR spectra, EPR spectral studies, powder X-ray diffraction (XRD) and electrochemical studies. The new complexes were found to be effective catalysts for aryl-aryl coupling and the oxidation of alcohols into their corresponding carbonyl compounds, respectively, using molecular oxygen atmosphere at ambient temperature. Further, the new Ru(III) Schiff base complexes were screened for their antibacterial activity against Pseudomonas aeruginosa, Vibrio cholera, Salomonella typhi and Staphylococcus aureaus.

  6. A computational study of ligand binding affinities in iron(III) porphine and protoporphyrin IX complexes.

    PubMed

    Durrant, Marcus C

    2014-07-01

    The search for novel anti-malarial drugs that can disrupt biomineralization of ferriprotoporphyrin IX to haemozoin requires an understanding of the fundamental chemistry of the porphyrin's iron(iii) centre at the water-lipid interface. Towards this end, the binding affinities for a diverse set of 31 small ligands with iron(iii) porphine have been calculated using density functional theory, in the gas phase and also with implicit solvent corrections for both water and n-octanol. In addition, the binding of hydroxide, chloride, acetate, methylamine and water to ferriprotoporphyrin IX has been studied, and very similar trends are observed for the smaller and larger models. Anionic ligands generally give stronger binding than neutral ones; the strongest binding is observed for RO(-) and OH(-) ligands, whilst acetate binds relatively weakly among the anions studied. Electron-rich nitrogen donors tend to bind more strongly than electron-deficient ones, and the weakest binding is found for neutral O and S donors such as oxazole and thiophene. In all cases, ligand binding is stronger in n-octanol than in water, and the differences in binding energies for the two solvents are greater for ionic ligands than for neutrals. Finally, dimerization of ferriprotoporphyrin IX by means of iron(iii)-carboxylate bond formation has been modelled. The results are discussed in terms of haemozoin crystal growth and its disruption by known anti-malarial drugs.

  7. Characterization of microbially Fe(III)-reduced nontronite: Environmental cell-transmission electron microscopy study

    USGS Publications Warehouse

    Kim, J.-W.; Furukawa, Y.; Daulton, T.L.; Lavoie, D.; Newell, S.W.

    2003-01-01

    Microstructural changes induced by the microbial reduction of Fe(III) in nontronite by Shewanella oneidensis were studied using environmental cell (EC)-transmission electron microscopy (TEM), conventional TEM, and X-ray powder diffraction (XRD). Direct observations of clays by EC-TEM in their hydrated state allowed for the first time an accurate and unambiguous TEM measurement of basal layer spacings and the contraction of layer spacing caused by microbial effects, most likely those of Fe(III) reduction. Non-reduced and Fe(III)-reduced nontronite, observed by EC-TEM, exhibited fringes with mean d001 spacings of 1.50 nm (standard deviation, ?? = 0.08 nm) and 1.26 nm (?? = 0.10 nm), respectively. In comparison, the same samples embedded with Nanoplast resin, sectioned by microtome, and observed using conventional TEM, displayed layer spacings of 1.0-1.1 nm (non-reduced) and 1.0 nm (reduced). The results from Nanoplast-embedded samples are typical of conventional TEM studies, which have measured nearly identical layer spacings regardless of Fe oxidation state. Following Fe(III) reduction, both EC- and conventional TEM showed an increase in the order of nontronite selected area electron diffraction patterns while the images exhibited fewer wavy fringes and fewer layer terminations. An increase in stacking order in reduced nontronite was also suggested by XRD measurements. In particular, the ratio of the valley to peak intensity (v/p) of the 1.7 nm basal 001 peak of ethylene glycolated nontronite was measured at 0.65 (non-reduced) and 0.85 (microbially reduced).

  8. Study of the thermodynamics of chromium(III) and chromium(VI) binding to iron(II/III)oxide or magnetite or ferrite and magnanese(II) iron (III) oxide or jacobsite or manganese ferrite nanoparticles.

    PubMed

    Luther, Steven; Brogfeld, Nathan; Kim, Jisoo; Parsons, J G

    2013-06-15

    Removal of chromium(III) or (VI) from aqueous solution was achieved using Fe3O4, and MnFe2O4 nanomaterials. The nanomaterials were synthesized using a precipitation method and characterized using XRD. The size of the nanomaterials was determined to be 22.4±0.9 nm (Fe3O4) and 15.5±0.5 nm (MnFe2O4). The optimal binding pH for chromium(III) and chromium(VI) were pH 6 and pH 3. Isotherm studies were performed, under light and dark conditions, to determine the capacity of the nanomaterials. The capacities for the light studies with MnFe2O4 and Fe3O4 were determined to be 7.189 and 10.63 mg/g, respectively, for chromium(III). The capacities for the light studies with MnFe2O4 and Fe3O4 were 3.21 and 3.46 mg/g, respectively, for chromium(VI). Under dark reaction conditions the binding of chromium(III) to the MnFe2O4 and Fe3O4 nanomaterials were 5.74 and 15.9 mg/g, respectively. The binding capacity for the binding of chromium(VI) to MnFe2O4 and Fe3O4 under dark reaction conditions were 3.87 and 8.54 mg/g, respectively. The thermodynamics for the reactions showed negative ΔG values, and positive ΔH values. The ΔS values were positive for the binding of chromium(III) and for chromium(VI) binding under dark reaction conditions. The ΔS values for chromium(VI) binding under the light reaction conditions were determined to be negative.

  9. Hydrologic studies in wells open through large intervals

    SciTech Connect

    Not Available

    1992-01-01

    This report describes and summarizes activities, data, and preliminary data interpretation from the INEL Oversight Program R D-1 project titled Hydrologic Studies In Wells Open Through Large Intervals.'' The project is designed to use a straddle-packer system to isolate, hydraulically test, and sample specific intervals of monitoring wells that are open (uncased, unscreened) over large intervals of the Snake River Plain aquifer. The objectives of the project are to determine and compare vertical variations in water quality and aquifer properties that have previously only been determined in an integrated fashion over the entire thickness of the open interval of the observation wells.

  10. Relationship between Class III malocclusion and hyoid bone displacement during swallowing: a cine-magnetic resonance imaging study

    PubMed Central

    Gokce, Hasan Suat; Gorgulu, Serkan; Karacay, Seniz; Akca, Eralp; Olmez, Huseyin

    2012-01-01

    Objective The displacement of the hyoid bone (HB) is a critical biomechanical component of the swallowing function. The aim of this study was to evaluate the swallowing-induced vertical and horizontal displacements of the HB in subjects with 2 different magnitudes of skeletal Class III malocclusion, by means of real-time, balanced turbo-field-echo (B-TFE) cine-magnetic resonance imaging. Methods The study population comprised 19 patients with mild skeletal Class III malocclusion, 16 with severe skeletal Class III malocclusion, and 20 with a skeletal Class I relationship. Before the commencement of the study, all subjects underwent cephalometric analysis to identify the nature of skeletal malformations. B-TFE images were obtained for the 4 consecutive stages of deglutition as each patient swallowed 10 mL of water, and the vertical and horizontal displacements of the HB were measured at each stage. Results At all stages of swallowing, the vertical position of the HB in the severe Class III malocclusion group was significantly lower than those in the mild Class III and Class I malocclusion groups. Similarly, the horizontal displacement of the HB was found to be significantly associated with the severity of malocclusion, i.e., the degree of Class III malocclusion, while the amount of anterior displacement of the HB decreased with an increase in the severity of the Class III deformity. Conclusions Our findings indicate the existence of a relationship between the magnitude of Class III malocclusion and HB displacement during swallowing. PMID:23112950

  11. The interaction of phenolic acids with Fe(III) in the presence of citrate as studied by isothermal titration calorimetry.

    PubMed

    Yang, Senpei; Bai, Guangling; Chen, Lingli; Shen, Qun; Diao, Xianmin; Zhao, Guanghua

    2014-08-15

    Under physiological conditions, exogenous chelators such as polyphenols might interact with non-protein bound ferric complexes, such as Fe(III)-citrate. Additionally, Fe(III) and citrate are widely distributed in various fruits and vegetables which are also rich in phenolic acids. In this study, we focus on the interaction between phenolic acids (gallic acid, methyl gallate and protocatechuic acid) and Fe(III) in the presence of excessive citrate by isothermal titration calorimetry (ITC) for thermodynamic studies, and stopped-flow absorption spectrometry for fast kinetic studies. Results reveal that all of these three phenolic acids can bind to the Fe(III) with the same stoichiometry (3:1). Moreover, the binding constants of these three compounds with Fe(III) are greatly dependent on ligand structure, and are much higher than that of Fe(III)-citrate. Based on their stoichiometry and superhigh binding constants, it is most likely that these three phenolic acids can displace the citrate to bind with one iron(III) ion to form a stable octahedral geometric structure, albeit at different rates. These findings shed light on the interaction between phenolic acids and Fe(III) in the presence of citrate under either physiological conditions or in a food system.

  12. Immunological studies on beef-heart ubiquinol--cytochrome c reductase (complex III)

    PubMed

    Nelson, B D; Mendel-Hartvig, I

    1977-10-17

    Antibodies against isolated beef-heart ubiquinol--cytochrome c reductase (complex III) have been characterized. Antibodies to complex III react strongly with isolated beef heart complex III and intact beef heart mitochondria, as shown by immunodiffusion and rocket electrophoresis experiments. The complex III content of intact mitochondria can be quantitated with rocket electrophoresis using isolated complex III as a standard. Antibodies to complex III also react with beef liver mitochondria and with both heart and liver mitochondria from rats. The latter are very weak antigens compared to beef heart material. Antibodies to complex III do not react with respiratory chain complexes I and IV, or F1-ATPase from beef heart mitochondria, but gives a slight, but variable, reaction with complex II and the membrane fraction isolated from complex V (oligomycin-sensitive ATPase). Antigenic sites are located on at least five of the seven peptides of complex III. These peptides are presumably lacking in respiratory chain complexes which do not react with antibodies to complex III, and are assumed to be uniquely located in complex III. Antiserum against complex III inhibitis duroquinol--cytochrome c reductase activity in isolated complex III and in complex III incorporated into phospholipid vesicles. Oxidation of NADH and succinate is not affected in submitochondrial particles treated with 6-times more antibody than required for complete inhibition of enzyme activity in free complex III or in complex III-phospholipid vesicles.

  13. Study of Cr (III) biosorption in a fixed-bed column.

    PubMed

    Calero, M; Hernáinz, F; Blázquez, G; Tenorio, G; Martín-Lara, M A

    2009-11-15

    This research analyzes the potential use of the olive stone as a low-cost biosorbent for Cr (III) from aqueous solutions in a continuous system. First, experiments were carried out in fixed-bed column to test the influence of various parameters on breakthrough and saturation time. The breakthrough and saturation time increase with the decrease of the flow rate. The same effect is shown when the bed depth is increased. The olive stone sorption capacity, q(e), increases as the inlet Cr (III) concentration increases until a value close to 0.800 mg/g is reached, then q(e) remains constant. Column data obtained at different conditions were described using the Adams-Bohart, Thomas, Yoon and Nelson, and Dose-Response models. The breakthrough curve prediction by the Adams-Bohart and Dose-Response models were found to be very satisfactory. In particular, the Adams-Bohart model can be used to represent the initial region of breakthrough curve, whereas the Dose-Response model is the one which best reproduces the whole curve for all the inlet Cr (III) concentrations used. Finally, a study of pH evolution was carried out. The pH increases at the beginning, subsequently decreasing as time passes until practically reaching the initial value. PMID:19616378

  14. A case study for assessment of consistency between ASME Section III and XI rules

    SciTech Connect

    Zhao, Y.; Wilkowski, G.

    1996-12-01

    A case study was conducted to evaluate how the current ASME Boiler and Pressure Vessel (B and PV) Code Section XI nuclear piping flaw evaluation rules are affected by the design stress changes in increasing the allowable stress with the B and PV Code Section III piping design rules. A piping model was developed for this purpose from a realistic nuclear piping referred to as BM3 that has been used widely for developing or evaluating the nuclear piping design rules. The piping system was modified so that all the conditions required by the 1995 Section III rules are met. Seismic excitations and internal pressure were increased to reach the maximum allowable stresses under the Section III rules including the effects of pressure, deadweight, seismic inertia, seismic anchor motion, and thermal expansion. The stresses thus calculated elastically using a finite element analysis were then combined using the Section XI rules to evaluate whether the maximum stress ratios for flaw acceptance are exceeded that are allowed by Section XI IWB-3514 for the workmanship standard flaw sizes corresponding to current nondestructive examination capability at butt weld areas. Quantitative results were provided for discussions.

  15. Kinetic studies of nitrate removal from aqueous solution using granular chitosan-Fe(III) complex.

    PubMed

    Hu, Qili; Chen, Nan; Feng, Chuanping; Zhang, Jing; Hu, Weiwu; Lv, Long

    2016-01-01

    In the present study, a granular chitosan-Fe(III) complex was prepared as a feasible adsorbent for the removal of nitrate from an aqueous solution. There was no significant change in terms of nitrate removal efficiency over a wide pH range of 3-11. Nitrate adsorption on the chitosan-Fe(III) complex followed the Langmuir-Freundlich isotherm model. In order to more accurately reflect adsorption and desorption behaviors at the solid/solution interface, kinetic model I and kinetic model II were proposed to simulate the interfacial process in a batch system. Nitrate adsorption on the chitosan-Fe(III) complex followed the pseudo-first-order kinetic model and kinetic model I. The proposed half-time could provide useful information for optimizing process design. Adsorption and desorption rate constants obtained from kinetic model I and kinetic model II were beneficial to understanding the interfacial process and the extent of adsorption reaction. Kinetic model I and kinetic model II implied that nitrate uptake exponentially approaches a limiting value. PMID:26942545

  16. Device physics studies of III-V and silicon MOSFETs for digital logic

    NASA Astrophysics Data System (ADS)

    Pal, Himadri Sekhar

    III-V's are currently gaining a lot of attraction as possible MOSFET channel materials due to their high intrinsic mobility. Several challenges, however, need to be overcome before III-V's can replace silicon (Si) in extremely scaled devices. The effect of low density-of-states of III-V materials is investigated by analyzing the semiconductor capacitance for different device structures and scaling. Solid solubility limit of dopants in the III-V materials are also significantly lower than that in Si, causing high series resistance, and transconductance degradation due to source exhaustion. The metallic source/drain Schottky barrier MOSFET is explored as an alternative to effectively eliminate these issues. The performance of a Si channel SOI MOSFET fabricated at IBM is analyzed and interpreted using ballistic transport. The ballistic ratio and extracted mean free paths demonstrate that scattering effects cannot be ignored in modern Si channel devices. Scattering has been implemented within the non-equilibrium Green's function (NEGF) framework to investigate effects of phonon and surface roughness scattering on device performance. The computational complexity is greatly reduced by analytically integrating over the transverse (width) dimension, making it possible to include scattering in planar FETs. The model has been carefully benchmarked with analytical formulas and Boltzmann transport calculations (2-D Monte Carlo results) for simple potential profiles. The scattering model is used to study the role of phonon scattering on the on-state characteristics of Si channel devices. Finally, the role of surface roughness scattering and its implementation issues within NEGF is discussed.

  17. Clinical evaluation of the centrifugal pump in open heart surgery: a comparative study of different pumps.

    PubMed

    Takarabe, K; Yoshikai, M; Murayama, J; Hamada, M; Ito, T

    1997-07-01

    The centrifugal pump is now widely used in open heart surgery for its clinical benefits related to the blood elements and the coagulation system. The purpose of this study was to compare the clinical performances of and the outcomes offered by 4 types of centrifugal pumps. For each pump, we investigated the effects on the blood elements, coagulation system, complements, and immunoglobulins during open heart surgery. Four types of centrifugal pumps were used: the HPM-15 (Nikkiso Co.), the Capiox (Terumo Co.), the Lifestream (St. Jude Medical Co.), and the BP-80 (Medtronic, BioMedicus Co.). The platelet count, lactate dehydrogenase (LDH), antithrombin III (AT III), thrombin-antithrombin complex (TAT), complements (C3, C4, and CH50), and immunoglobulins (IgG, IgA, and IgM) were measured before and after cardiopulmonary bypass (CPB). The platelet count was decreased more significantly by the HPM-15 than by any of the other pumps. The other parameters showed no difference among the 4 pumps. In clinical use, each of the 4 types of centrifugal pumps was safe.

  18. The WIYN Open Cluster Study: A 15-Year Report

    NASA Astrophysics Data System (ADS)

    Mathieu, Robert D.; WOCS Collaboration

    2013-06-01

    The WIYN 3.5m telescope combines large aperture, wide field of view and superb image quality. The WIYN consortium includes investigators in numerous areas of open cluster research. The combination spawned the WIYN Open Cluster Study (WOCS) over a decade ago, with the goals of producing 1) comprehensive photometric, astrometric and spectroscopic data for new fundamental open clusters and 2) addressing key astrophysical problems with these data. The set of core WOCS open clusters spans age and metallicity. Low reddening, solar proximity and richness were also desirable features in selecting core open clusters. More than 50 WIYN Open Cluster Study papers have been published in refereed journals. Highlights include: deep and wide-field photometry of NGC 188, NGC 2168 (M35), and NGC 6819 (WOCS I, II, XI and LII); deep and wide-field proper-motion studies of the old open clusters NGC 188, NGC 2682 (M67) and NGC 6791 (WOCS XVII, XXXIII and XLVI); comprehensive radial-velocity surveys of NGC 188, NGC 2168 and NGC 6819 (WOCS XXXII, XXIV, and XXXVIII); metallicity and lithium abundances in NGC 2168 (WOCS V); comprehensive definition of the hard-binary populations of NGC 188 and NGC 2168 (WOCS XXII and XLVIII); rotation period distributions in NGC 1039 (M34) and NGC 2168 (WOCS XXXV, XLIII, and XLV); study of chromospheric activity in NGC 2682 (WOCS XVIII); photometric variability surveys in NGC 188 and NGC 2682 (IX and XV); new Bayesian techniques for determination of cluster parameters (WOCS XXIII); a new infrared age-diagnostic for open clusters (WOCS XL); theoretical studies of stellar rotation (WOCS XIII and XIV); sophisticated N-body simulations of NGC 188 (WOCS LI); and the discovery of a high binary frequency and white dwarf companions among NGC 188 blue stragglers. While the WIYN 3.5m telescope remains at its heart, today the WIYN Open Cluster Study collaboration extends beyond both the WIYN observatory and consortium, and continues as a vital and productive

  19. Complexation of Lactate with Nd(III) and Eu(III) at Variable Temperatures: Studies by Potentiometry, Microcalorimetry, Optical Absorption and Luminescence Spectroscopy

    SciTech Connect

    Tian, Guoxin; Martin, Leigh R.; Rao, Linfeng

    2010-10-01

    Complexation of neodymium(III) and europium(III) with lactate was studied at variable temperatures by potentiometry, absorption spectrophotometry, luminescence spectroscopy and microcalorimetry. Stability constants of three successive lactate complexes (ML{sup 2+}, ML{sup 2+} and ML{sub 3}(aq), where M stands for Nd and Eu, and L stands for lactate) at 10, 25, 40, 55 and 70 C were determined. The enthalpies of complexation at 25 C were determined by microcalorimetry. Thermodynamic data show that the complexation of trivalent lanthanides (Nd{sup 3+} and Eu{sup 3+}) with lactate is exothermic, and the complexation becomes weaker at higher temperatures. Results from optical absorption and luminescence spectroscopy suggest that the complexes are inner-sphere chelate complexes in which the protonated {alpha}-hydroxyl group of lactate participates in the complexation.

  20. Complexation of lactate with neodymium(III) and europium(III) at variable temperatures: studies by potentiometry, microcalorimetry, optical absorption, and luminescence spectroscopy.

    PubMed

    Tian, Guoxin; Martin, Leigh R; Rao, Linfeng

    2010-11-15

    The complexation of neodymium(III) and europium(III) with lactate was studied at variable temperatures by potentiometry, absorption spectrophotometry, luminescence spectroscopy, and microcalorimetry. The stability constants of three successive lactate complexes (ML(2+), ML(2)(+), and ML(3)(aq), where M stands for Nd and Eu and L stands for lactate) at 10, 25, 40, 55, and 70 °C were determined. The enthalpies of complexation at 25 °C were determined by microcalorimetry. Thermodynamic data show that the complexation of trivalent lanthanides (Nd(3+) and Eu(3+)) with lactate is exothermic and the complexation becomes weaker at higher temperatures. Results from optical absorption and luminescence spectroscopy suggest that the complexes are inner-sphere chelate complexes in which the protonated α-hydroxyl group of lactate participates in the complexation.

  1. A Phase I-II Study of Postoperative Capecitabine-Based Chemoradiotherapy in Gastric Cancer

    SciTech Connect

    Jansen, Edwin; Crosby, Tom D.L.; Dubbelman, Ria; Bartelink, Harry; Verheij, Marcel

    2007-12-01

    Background: The Intergroup 0116 randomized study showed that postoperative 5-fluorouracil-based chemoradiotherapy improved locoregional control and overall survival in patients with gastric cancer. We hypothesized that these results could be improved further by using a more effective, intensified, and convenient chemotherapy schedule. Therefore, this Phase I-II dose-escalation study was performed to determine the maximal tolerated dose and toxicity profile of postoperative radiotherapy combined with concurrent capecitabine. Patients and Methods: After recovery from surgery for adenocarcinoma of the gastroesophageal junction or stomach, all patients were treated with capecitabine monotherapy, 1,000 mg/m{sup 2} twice daily for 2 weeks. After a 1-week treatment-free interval, patients received capecitabine (650-1,000 mg/m{sup 2} orally twice daily 5 days/week) in a dose-escalation schedule combined with radiotherapy on weekdays for 5 weeks. Radiotherapy was delivered to a total dose of 45 Gy in 25 fractions to the gastric bed, anastomoses, and regional lymph nodes. Results: Sixty-six patients were treated accordingly. Two patients went off study before or shortly after the start of chemoradiotherapy because of progressive disease. Therefore, 64 patients completed treatment as planned. During the chemoradiotherapy phase, 4 patients developed four items of Grade III dose-limiting toxicity (3 patients in Dose Level II and 1 patient in Dose Level IV). The predefined highest dose of capecitabine, 1,000 mg/m{sup 2} twice daily orally, was tolerated well and, therefore, considered safe for further clinical evaluation. Conclusions: This Phase I-II study shows that intensified chemoradiotherapy with daily capecitabine is feasible in postoperative patients with gastroesophageal junction and gastric cancer.

  2. Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study

    PubMed Central

    Heshmat, Ramin; Shafiee, Gita; Qorbani, Mostafa; Azizi-Soleiman, Fatemeh; Djalalinia, Shirin; Esmaeil Motlagh, Mohammad; Ardalan, Gelayol; Ahadi, Zeinab; Safari, Omid; Safiri, Saeid; Kelishadi, Roya

    2016-01-01

    Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria modified for children and adolescents. Anthropometric measures (including body mass index [BMI], waist circumference [WC] and waist to height ratio [WHtR]), blood pressure (BP) and biochemical data (including fasting blood sugar [FBS], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC] and gerlin) were measured. Results: Total ghrelin level was significantly higher in students without MetS compared to those with MetS (748.89 ± 85.04 vs. 728.72 ± 90.36 [pg/mL]; P < 0.001). Significant negative correlations were seen between ghrelin levels and BMI, WC, WHtR, TG, and TC. Ghrelin had also relatively strong inverse correlations with FBS (r = −0.59, P< 0.001), LDL-C (r = −0.56, P < 0.001), and positive correlation with HDL-C (r = 0.60, P < 0.001). Compared with the children with MetS, in those without MetS, ghrelin was significantly associated with HDL-C and LDL-C. A decreasing trend was observed in the mean ghrelin level across increasing number of MetS components (P for trend <0.001). Conclusion: We observed a relationship between ghrelin concentration and MetS components in adolescents. PMID:27777695

  3. Phase III integrated water recovery testing at MSFC - Partially closed hygiene loop and open potable loop results and lessons learned

    NASA Technical Reports Server (NTRS)

    Bagdigian, R. M.; Traweek, M. S.; Griffith, G. K.; Griffin, M. R.

    1991-01-01

    A series of tests has been conducted at the NASA Marshall Space Flight Center (MSFC) to evaluate the performance of a predevelopment water recovery system. Potable, hygiene, and urine reclamation subsystems were integrated with end-use equipment items and successfully operated in open and partially closed-loop modes, with man-in-the-loop, for a total of 28 days. Several significant subsystem physical anomalies were encountered during testing. Reclaimed potable and hygiene water generally met the current Space Station Freedom (SSF) water quality specifications for inorganic and microbiological constituents, but exceeded the maximum allowable concentrations for Total Organic Carbon (TOC). This paper summarizes the test objectives, system design, test activities/protocols, significant results/anomalies, and major lessons learned.

  4. Synthesis, spectroscopic, thermal and antimicrobial studies of neodymium(III) and samarium(III) complexes derived from tetradentate ligands containing N and S donor atoms

    NASA Astrophysics Data System (ADS)

    Ain, Qurratul; Pandey, S. K.; Pandey, O. P.; Sengupta, S. K.

    2015-04-01

    Trivalent lanthanide complexes of the type [Ln(L)Cl(H2O)2] (where Ln = Nd(III) or Sm(III) and LH2 = Schiff bases derived by the condensation of 3-(phenyl/substitutedphenyl)-4-amino-5-mercapto-1,2,4-triazole with diacetyl/benzil) have been synthesized by the reactions of anhydrous lanthanide(III) chloride with Schiff bases in methanol. The structures of the complexes have been proposed on the basis of elemental analysis, electrical conductance, magnetic moment, spectroscopic measurements (IR, 1H, 13C NMR and UV-vis spectra) and X-ray diffraction studies. The spectral data reveal that the Schiff base ligands behave as dibasic tetradentate chelating agents having coordination sites at two thiol sulfur atoms and two azomethine nitrogen atoms. The presence of coordinated water in metal complexes was confirmed by thermal and IR data of the complexes. All the Schiff bases and their metal complexes have also been screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus and antifungal activities against Aspergillus niger, Curvularia pallescens and Colletotrichum capsici.

  5. Measurements and Modeling To Determine the Reduction Potential of Uncomplexed Bi(III) in Nitrate Solutions for Application in Bi(III)-Ligand Equilibria Studies by Voltammetry.

    PubMed

    Billing, Caren; Cukrowski, Ignacy

    2016-05-12

    The free metal ion potential, E(M), is a critical parameter in the calculation of formation constants when using voltammetry. When studying complex formation of Bi(III), however, E(Bi) cannot be directly measured. In this work a nitrate background electrolyte was employed to obtain reversible reduction waves. To determine E(Bi), measurements have to be made below pH ∼ 2 before the bismuth-oxy-nitrate species precipitates and thus corrections for the diffusion junction potential (monitored using Tl(I) as an internal reference ion) must be made. Additionally shifts in potential due to both Bi(III) hydrolysis and Bi(III) nitrate formation must also be compensated for before E(Bi) can be evaluated. The value of E(Bi) was determined relative to E(Tl) so that in an experiments where ligand is added to determine formation constants, E(Bi) can be determined as accurately as possible (since E(Tl) can generally still be measured). The value of E(Bi) - E(Tl) was found to be 495.6 ± 1.4 mV for the conditions employed. PMID:27088843

  6. Synthesis, spectroscopic, thermal and antimicrobial studies of neodymium(III) and samarium(III) complexes derived from tetradentate ligands containing N and S donor atoms.

    PubMed

    Ain, Qurratul; Pandey, S K; Pandey, O P; Sengupta, S K

    2015-04-01

    Trivalent lanthanide complexes of the type [Ln(L)Cl(H2O)2] (where Ln=Nd(III) or Sm(III) and LH2=Schiff bases derived by the condensation of 3-(phenyl/substitutedphenyl)-4-amino-5-mercapto-1,2,4-triazole with diacetyl/benzil) have been synthesized by the reactions of anhydrous lanthanide(III) chloride with Schiff bases in methanol. The structures of the complexes have been proposed on the basis of elemental analysis, electrical conductance, magnetic moment, spectroscopic measurements (IR, 1H, 13C NMR and UV-vis spectra) and X-ray diffraction studies. The spectral data reveal that the Schiff base ligands behave as dibasic tetradentate chelating agents having coordination sites at two thiol sulfur atoms and two azomethine nitrogen atoms. The presence of coordinated water in metal complexes was confirmed by thermal and IR data of the complexes. All the Schiff bases and their metal complexes have also been screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus and antifungal activities against Aspergillus niger, Curvularia pallescens and Colletotrichum capsici.

  7. A Confirmatory Factor Analytic Study of the Wechsler Memory Scale-III in an Elderly Norwegian Sample.

    PubMed

    Bosnes, Ole; Troland, Kari; Torsheim, Torbjoern

    2016-02-01

    This study compared the factor structure of the translated Wechsler Memory Scale-III (WMS-III), which is the latest available version in Norway, with the original U.S. version. A sample of 122 healthy, elderly Norwegians (mean age: 74; standard deviation = 8.8) completed the WMS-III. The factor structure of the translated WMS-III was tested, using Confirmatory Factor Analysis, with comparison of model fit based on five a priori hypothesized models. Several model fit indices pointed to a three-factor model (working memory, visual memory, and auditory memory) providing the best fit to the data. Our study supports updated findings of the original WMS-III in nonclinical samples and suggests that the translated version is structurally equal to the original. The study supports the cross-cultural validity of the WMS-III. However, based on the present data, one might expect scores on the Family Pictures subtest to fall below scores on other WMS-III subtests in elderly Norwegians.

  8. Theoretical studies on the photophysical properties of some Iridium (III) complexes used for OLED

    NASA Astrophysics Data System (ADS)

    Urinda, Sharmistha; Das, Goutam; Pramanik, Anup; Sarkar, Pranab

    2016-09-01

    The structural and photophysical properties of four heteroleptic Iridium (III) complexes, based on 1-phenylpyrazole ligand, have been investigated theoretically. The effect of chemical substitution on the absorption and the emission spectra of the complexes has been studied and compared with the experimental data. We observe a significant structural change in the lowest triplet excited state as compared to the ground singlet state. We compute the emission wavelength of the complexes by considering the spin-orbit coupling. Using these understandings, we predict two new complexes having deeper blue emission which are supposed to be better efficient OLED materials.

  9. Effects of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in grade III open tibia fractures treated with unreamed nails-A clinical and health-economic analysis.

    PubMed

    Alt, Volker; Borgman, Benny; Eicher, Alexander; Heiss, Christian; Kanakaris, Nikolaos K; Giannoudis, Peter V; Song, Fujian

    2015-11-01

    Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) is licensed in Europe for open tibia fractures treated with unreamed nails. However, there is limited data available on the specific use of rhBMP-2 in combination with unreamed nails for open tibia fractures. The intention of the current study was to evaluate the medical and health-economic effects of rhBMP-2 in Gustilo-Anderson grade III open tibia fractures treated with unreamed nails based on individual patient data from two previously published studies. Linear regression analysis was performed on raw data of 90 patients that were either treated by standard of care with soft tissue management and unreamed nailing (SOC group) (n=50) or with rhBMP-2 in addition to soft tissue management and unreamed nailing (rhBMP-2 group) (n=40). For all types of revision, a significant lower percentage of patients (27.5%) of the rhBMP-2 group had to be revised compared to 48% of the patients of the SOC group (p=0.04). When only invasive secondary interventions such as bone grafting and nail exchange were considered, there was also a statistically significant reduction in the rhBMP-2 group with a revision rate of 10.0% (4 of 40 patients) compared to the SOC group with a revision rate of 28.0% (14 of 50 patients) (p=0.01). Mean fracture healing time of 228 days in the rhBMP-2 compared to 266 days in the SOC group was not statistically significant (p=0.24). Health-economic analysis based on a societal perspective with calculation of overall treatment costs after initial surgery and including productivity losses revealed savings of €6,239 per patient for Germany and €4,752 for the UK in favour of rhBMP-2 which was mainly driven by reduction of productivity losses. In conclusion, rhBMP-2 reduces secondary interventions in patients with grade III open tibia fractures treated with an unreamed nail and its use leads to financial savings for Germany and the UK from a societal perspective.

  10. A Swift/UVOT Study of Open Clusters

    NASA Astrophysics Data System (ADS)

    LaPorte, Samuel; Siegel, Michael

    2016-01-01

    Star clusters, due to being coeval populations of similar stars, provide a convenient snapshot of a stellar population to study and compare to theoretical models of stellar evolution. They also serve as the empirical baseline for studies of distant unresolved stellar populations. However, few studies have been performed of detailed color-magnitude diagrams (CMDs) of young open clusters in the near ultraviolet. We present a sample of 92 open clusters compiled using Swift's Ultra-Violet and Optical Telescope (UVOT). We construct CMDs and perform isochrone fitting for the most luminous clusters to determine how well the theoretical models reproduce the salient features of the CMDs. We find that the isochrones provide excellent fits to the primary color-magnitude loci, lending confidence to models of unresolved stellar populations and providing, in the future, an opportunity to use open clusters to probe the UV properties of foreground dust.

  11. Interaction of Cm(III) and Am(III) with human serum transferrin studied by time-resolved laser fluorescence and EXAFS spectroscopy.

    PubMed

    Bauer, Nicole; Fröhlich, Daniel R; Panak, Petra J

    2014-05-14

    The complexation of Cm(III) with human serum transferrin was investigated in a pH range from 3.5 to 11.0 using time-resolved laser fluorescence spectroscopy (TRLFS). At pH ≥ 7.4 Cm(III) is incorporated at the Fe(III) binding site of transferrin whereas at lower pH a partially bound Cm(III) transferrin species is formed. At physiological temperature (310 K) at pH 7.4, about 70% of the partially bound and 30% of the incorporated Cm(III) transferrin species are present in solution. The Cm(III) results obtained by TRLFS are in very good agreement with Am(III) EXAFS results, confirming the incorporation of Am(III) at the Fe(III) binding site at pH 8.5.

  12. Results of the Promethee Method Application in Selecting the Technological System at the Majdan III Open Pit Mine / Wyniki Zastosowania Metody Promethee do Wyboru Systemu Technologicznego W Kopalni Odkrywkowej Majdan III

    NASA Astrophysics Data System (ADS)

    Vujić, Slobodan; Hudej, Marjan; Miljanović, Igor

    2013-12-01

    This paper discusses the application of the PROMETHEE model and the results achieved in practice, following the example of the multi-criteria selection of the technological system at the Majdan III clay mineral raw material open pit mine of the Potisje Company, Republic of Serbia. After the introduction comments, reasons are explained for selecting the new technological system, conditions and limitations for the seven alternative solutions considered are described, mathematical foundation for the PROMETHEE method and a multi-criteria model of the problem in question are presented. The solution with the following structure was ranked first and accepted by the Company management as the best: Bucket chain excavator - Conveyor belts - Spreader (ECS), alongside a decision is made on the acquisition of machinery and system construction. The system was put into operation in 2000. The experience and the data accumulated in the previous twelve years confirm that the decision made on the application of the ECS technology was just, and the conclusion lists the benefits achieved. W artykule omówiono zastosowanie modelu Promethee i przedyskutowano uzyskane w ten sposób wyniki na przykładzie wielokryterialnego wyboru systemu technologicznego do zastosowania w kopalni odkrywkowej minerałów ilastych Majdan III, należącej do przedsiębiorstwa górniczego Potisje (Republika Serbii). Po uwagach wprowadzających przedstawiono powody wyboru nowego ciągu technologicznego, omówiono warunki oraz ograniczenia dla siedmiu alternatywnych rozwiązań, podstawy matematyczne metody Promethee oraz wielokryterialny model zagadnienia. Rozwiązanie uznane za najlepsze i zaaprobowane przez zarząd przedsiębiorstwa zakłada zastosowanie następującego ciągu technologicznego: koparka łancuchowa jednonaczyniowa - przenośniki taśmowe - rozkładarka(system ECS). Podjęto także decyzje odnośnie zakupu sprzętu i instalacji systemu, który uruchomiony został w 2000 roku. Doświadczenia i

  13. Approaching the Kinetic Inertness of Macrocyclic Gadolinium(III)-Based MRI Contrast Agents with Highly Rigid Open-Chain Derivatives.

    PubMed

    Tircsó, Gyula; Regueiro-Figueroa, Martín; Nagy, Viktória; Garda, Zoltán; Garai, Tamás; Kálmán, Ferenc Krisztián; Esteban-Gómez, David; Tóth, Éva; Platas-Iglesias, Carlos

    2016-01-18

    A highly rigid open-chain octadentate ligand (H4 cddadpa) containing a diaminocylohexane unit to replace the ethylenediamine bridge of 6,6'-[(ethane-1,2 diylbis{(carboxymethyl)azanediyl})bis(methylene)]dipicolinic acid (H4 octapa) was synthesized. This structural modification improves the thermodynamic stability of the Gd(3+) complex slightly (log KGdL =20.68 vs. 20.23 for [Gd(octapa)](-) ) while other MRI-relevant parameters remain unaffected (one coordinated water molecule; relaxivity r1 =5.73 mm(-1)  s(-1) at 20 MHz and 295 K). Kinetic inertness is improved by the rigidifying effect of the diaminocylohexane unit in the ligand skeleton (half-life of dissociation for physiological conditions is 6 orders of magnitude higher for [Gd(cddadpa)](-) (t1/2 =1.49×10(5)  h) than for [Gd(octapa)](-) . The kinetic inertness of this novel chelate is superior by 2-3 orders of magnitude compared to non-macrocyclic MRI contrast agents approved for clinical use. PMID:26583317

  14. Study of Cobalt(III) Corrole as the Neutral Ionophore for Nitrite and Nitrate Detection via Polymeric Membrane Electrodes.

    PubMed

    Yang, Si; Meyerhoff, Mark E

    2013-12-01

    Cobalt(III) 5, 10, 15-tris(4-tert-butylphenyl) corrole was synthesized and incorporated into plasticized poly(vinyl chloride) membranes and studied as a neutral carrier ionophore via potentiometry. This cobalt(III) complex has binding affinity to nitrite, and the resulting membrane electrode yields reversible and Nernstian response toward nitrite. Enhanced nitrite selectivity is observed over other anions, including lipophilic anions such as thiocyanate and perchlorate when an appropriate amount of lipophilic cationic sites are added to the membrane phase. Detection limit to nitrite is ca. 5 µM. Using tributylphosphate as the plasticizer with the cobalt(III) corrole species yields electrodes with enhanced nitrate selectivity.

  15. Rationale and design of the Left Atrial Appendage Occlusion Study (LAAOS) III

    PubMed Central

    Healey, Jeff; Vincent, Jessica; Brady, Kate; Teoh, Kevin; Royse, Alistair; Shah, Pallav; Guo, Yingqiang; Alings, Marco; Folkeringa, Richard J.; Paparella, Domenico; Colli, Andrea; Meyer, Steven R.; Legare, Jean-François; Lamontagne, François; Reents, Wilko; Böning, Andreas; Connolly, Stuart

    2014-01-01

    Background Occlusion of the left atrial appendage (LAA) is a promising approach to stroke prevention in atrial fibrillation (AF). However, evidence of its efficacy and safety to date is lacking. We herein describe the rationale and design of a definitive LAA occlusion trial in cardiac surgical patients with AF. Methods We plan to randomize 4,700 patients with AF in whom on-pump cardiac surgical procedure is planned to undergo LAA occlusion or no LAA occlusion. The primary outcome is the first occurrence of stroke or systemic arterial embolism over a mean follow-up of four years. Other outcomes include total mortality, operative safety outcomes (chest tube output in the first post-operative 24 hours, rate of post-operative re-exploration for bleeding in the first 48 hours post-surgery and 30-day mortality), re-hospitalization for heart failure, major bleed, and myocardial infarction. Results Left Atrial Appendage Occlusion Study (LAAOS) III is funded in a vanguard phase by the Canadian Institutes for Health Research (CIHR), the Canadian Network and Centre for Trials Internationally, and the McMaster University Surgical Associates. As of September 9, 2013, 162 patients have been recruited into the study. Conclusions LAAOS III will be the largest trial to explore the efficacy of LAA occlusion for stroke prevention. Its results will lead to a better understanding of stroke in AF and the safety and efficacy of surgical LAA occlusion. PMID:24516797

  16. Open Source Drug Discovery in Practice: A Case Study

    PubMed Central

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Background Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. Methodology/Principal Findings A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Conclusions/Significance Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality

  17. A comparative study between shielded and open coplanar waveguide discontinuities

    NASA Technical Reports Server (NTRS)

    Dib, Nihad I.; Harokopus, W. P., Jr.; Ponchak, G. E.; Katehi, L. P. B.

    1993-01-01

    A comparative study between open and shielded coplanar waveguide (CPW) discontinuities is presented. The space domain integral equation method is used to characterize several discontinuities such as the open-end CPW and CPW series stubs. Two different geometries of CPW series stubs (straight and bent stubs) are compared with respect to resonant frequency and radiation loss. In addition, the encountered radiation loss due to different CPW shunt stubs is evaluated experimentally. The notion of forced radiation simulation is presented, and the results of such a simulation are compared to the actual radiation loss obtained rigorously. It is shown that such a simulation cannot give reliable results concerning radiation loss from printed circuits.

  18. Open Educational Resources: A Delphi Study of Instructional Design Quality

    ERIC Educational Resources Information Center

    Emerson, Marnice K.

    2013-01-01

    The purpose of this modified Delphi research study was to investigate instructional designers' beliefs about the instructional strategies and activities to be included in a universal framework for designing quality, self-directed, multimedia, open educational resources (OERs). With the rapid growth of availability and use of OERs by a widely…

  19. Synthesis, characterization and antibacterial studies of ruthenium(III) complexes derived from chitosan schiff base.

    PubMed

    Vadivel, T; Dhamodaran, M

    2016-09-01

    Chitosan can be modified chemically by condensation reaction of deacetylated chitosan with aldehyde in homogeneous phase. This condensation is carried by primary amine (NH2) with aldehyde (CHO) to form corresponding schiff base. The chitosan biopolymer schiff base derivatives are synthesized with substituted aldehydes namely 4-hydroxy-3-methoxy benzaldehyde, 2-hydroxy benzaldehyde, and 2-hydroxy-3-methoxy benzaldehyde, becomes a complexing agent or ligand. The Ruthenium(III) complexes were obtained by complexation of Ruthenium with schiff base ligands and this product exhibits as an excellent solubility and more biocompatibility. The novel series of schiff base Ruthenium(III) complexes are characterized by Elemental analysis, FT-IR spectroscopy, and Thermo-gravimetric analysis (TGA). The synthesized complexes have been subjected to antibacterial study. The antibacterial results indicated that the antibacterial activity of the complexes were more effective against Gram positive and Gram negative pathogenic bacteria. These findings are giving suitable support for developing new antibacterial agent and expand our scope for applications.

  20. Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials

    PubMed Central

    Stein, Donald G.

    2015-01-01

    Abstract Background: Despite positive preclinical studies and two positive Phase II clinical trials, two large Phase III clinical trials of progesterone treatment of acute traumatic brain injury (TBI) recently ended with negative results, so a 100% failure rate continues to plague the field of TBI trials. Methods: This paper reviews and analyses the trial structures and outcomes and discusses the implications of these failures for future drug and clinical trial development. Persistently negative trial outcomes have led to disinvestment in new drug research by companies and policy-makers and disappointment for patients and their families, failures which represent a major public health concern. The problem is not limited to TBI. Failure rates are high for trials in stroke, sepsis, cardiology, cancer and orthopaedics, among others. Results: This paper discusses some of the reasons why the Phase III trials have failed. These reasons may include faulty extrapolation from pre-clinical data in designing clinical trials and the use of subjective outcome measures that accurately reflect neither the nature of the deficits nor long-term quantitative recovery. Conclusions: Better definitions of injury and healing and better outcome measures are essential to change the embrace of failure that has dominated the field for over 30 years. This review offers suggestions to improve the situation. PMID:26274493

  1. A Statistical Study of Brown Dwarf Companions from the SDSS-III MARVELS Survey

    NASA Astrophysics Data System (ADS)

    Grieves, Nolan; Ge, Jian; Thomas, Neil; Ma, Bo; De Lee, Nathan M.; Lee, Brian L.; Fleming, Scott W.; Sithajan, Sirinrat; Varosi, Frank; Liu, Jian; Zhao, Bo; Li, Rui; Agol, Eric; MARVELS Team

    2016-01-01

    We present 23 new Brown Dwarf (BD) candidates from the Multi-object APO Radial-Velocity Exoplanet Large-Area Survey (MARVELS) of the Sloan Digital Sky Survey III (SDSS-III). The BD candidates were selected from the processed MARVELS data using the latest University of Florida 2D pipeline, which shows significant improvement and reduction of systematic errors over the 1D pipeline results included in the SDSS Data Release 12. This sample is the largest BD yield from a single radial velocity survey. Of the 23 candidates, 18 are around main sequence stars and 5 are around giant stars. Given a giant contamination rate of ~24% for the MARVELS survey, we find a BD occurrence rate around main sequence stars of ~0.7%, which agrees with previous studies and confirms the BD desert, while the BD occurrence rate around the MARVELS giant stars is ~0.6%. Preliminary results show that our new candidates around solar type stars support a two population hypothesis, where BDs are divided at a mass of ~42.5 MJup. BDs less massive than 42.5 MJup have eccentricity distributions consistent with planet-planet scattering models, where BDs more massive than 42.5 MJup have both period and eccentricity distributions similar to that of stellar binaries. Special Brown Dwarf systems such as multiple BD systems and highly eccentric BDs will also be presented.

  2. Complexes of ruthenium(III) with some 2-aminothiazole derivatives/synthesis, properties and pharmacological studies.

    PubMed

    Nikolova, Antonina; Ivanov, Darvin; Bontchev, Panayot; Buyukliev, Rossen; Mehandjiev, Dimitar; Gochev, Georgi; Konstantinov, Spiro; Karaivanova, Margarita

    2004-01-01

    Four new complexes of Ru(III) with a general formula [Ru(L)2Cl2]Cl, where L = 2-amino-4-phenylthiazole (CAS 2010-06-2), 2-amino-4-methylthiazole (CAS 1603-91-4), ethyl 2-amino-4-methyl-5-thiazolecarboxylate (CAS 7210-76-6) and ethyl 2-amino-4-phenyl-5-thiazolecarboxylate (CAS 64399-23-1), were prepared. The syntheses were carried out in polar medium and inert atmosphere at a molar ratio Ru:L = 1:2 or 1:3. The compounds obtained were characterised by IR-, 1H-NMR- 13C-NMR-, UV-VIS-, EPR spectroscopy, magnetochemical and conductivity measurements. The ligands behaved as bidental, bounding Ru(III) through the nitrogen atoms from the amino group and the heterocycle. The complex of ethyl 2-amino-4-phenyl-5-thiazolecarboxylate showed significant antileukaemic activity on various human cells (IC50 values ranging from 20 to 92 micromol/l). Toxicological studies on mice indicated that such concentrations could be reached without mortality. This compound exhibited a promising antineoplastic potential and needs further pharmacological and toxicological evaluation.

  3. Openings

    PubMed Central

    Selwyn, Peter A.

    2015-01-01

    Reviewing his clinic patient schedule for the day, a physician reflects on the history of a young woman he has been caring for over the past 9 years. What starts out as a routine visit then turns into a unique opening for communication and connection. A chance glimpse out the window of the exam room leads to a deeper meditation on parenthood, survival, and healing, not only for the patient but also for the physician. How many missed opportunities have we all had, without even realizing it, to allow this kind of fleeting but profound opening? PMID:26195687

  4. Development of Two Animal Models To Study the Function of Vibrio parahaemolyticus Type III Secretion Systems▿

    PubMed Central

    Piñeyro, Pablo; Zhou, Xiaohui; Orfe, Lisa H.; Friel, Patrick J.; Lahmers, Kevin; Call, Douglas R.

    2010-01-01

    Vibrio parahaemolyticus is an emerging food- and waterborne pathogen that encodes two type III secretion systems (T3SSs). Previous studies have linked type III secretion system 1 (T3SS1) to cytotoxicity and T3SS2 to intestinal fluid accumulation, but animal challenge models needed to study these phenomena are limited. In this study we evaluated the roles of the T3SSs during infection using two novel animal models: a model in which piglets were inoculated orogastrically and a model in which mice were inoculated in their lungs (intrapulmonarily). The bacterial strains employed in this study had equivalent growth rates and beta-hemolytic activity based on in vitro assays. Inoculation of 48-h-old conventional piglets with 1011 CFU of the wild-type strain (NY-4) or T3SS1 deletion mutant strains resulted in acute, self-limiting diarrhea, whereas inoculation with a T3SS2 deletion mutant strain failed to produce any clinical symptoms. Intrapulmonary inoculation of C57BL/6 mice with the wild-type strain and T3SS2 deletion mutant strains (5 × 105 CFU) induced mortality or a moribund state within 12 h (80 to 100% mortality), whereas inoculation with a T3SS1 deletion mutant or a T3SS1 T3SS2 double deletion mutant produced no mortality. Bacteria were recovered from multiple organs regardless of the strain used in the mouse model, indicating that the mice were capable of clearing the lung infection in the absence of a functional T3SS1. Because all strains had a similar beta-hemolysin phenotype, we surmise that thermostable direct hemolysin (TDH) plays a limited role in these models. The two models introduced herein produce robust results and provide a means to determine how different T3SS1 and T3SS2 effector proteins contribute to pathogenesis of V. parahaemolyticus infection. PMID:20823199

  5. III-antimonide/nitride based semiconductors for optoelectronic materials and device studies : LDRD 26518 final report.

    SciTech Connect

    Kurtz, Steven Ross; Hargett, Terry W.; Serkland, Darwin Keith; Waldrip, Karen Elizabeth; Modine, Normand Arthur; Klem, John Frederick; Jones, Eric Daniel; Cich, Michael Joseph; Allerman, Andrew Alan; Peake, Gregory Merwin

    2003-12-01

    The goal of this LDRD was to investigate III-antimonide/nitride based materials for unique semiconductor properties and applications. Previous to this study, lack of basic information concerning these alloys restricted their use in semiconductor devices. Long wavelength emission on GaAs substrates is of critical importance to telecommunication applications for cost reduction and integration into microsystems. Currently InGaAsN, on a GaAs substrate, is being commercially pursued for the important 1.3 micrometer dispersion minima of silica-glass optical fiber; due, in large part, to previous research at Sandia National Laboratories. However, InGaAsN has not shown great promise for 1.55 micrometer emission which is the low-loss window of single mode optical fiber used in transatlantic fiber. Other important applications for the antimonide/nitride based materials include the base junction of an HBT to reduce the operating voltage which is important for wireless communication links, and for improving the efficiency of a multijunction solar cell. We have undertaken the first comprehensive theoretical, experimental and device study of this material with promising results. Theoretical modeling has identified GaAsSbN to be a similar or potentially superior candidate to InGaAsN for long wavelength emission on GaAs. We have confirmed these predictions by producing emission out to 1.66 micrometers and have achieved edge emitting and VCSEL electroluminescence at 1.3 micrometers. We have also done the first study of the transport properties of this material including mobility, electron/hole mass, and exciton reduced mass. This study has increased the understanding of the III-antimonide/nitride materials enough to warrant consideration for all of the target device applications.

  6. Fulvic acid complexation of Eu(III) and Cm(III) at elevated temperatures studied by time-resolved laser fluorescence spectroscopy.

    PubMed

    Fröhlich, Daniel R; Skerencak-Frech, Andrej; Gast, Michael; Panak, Petra J

    2014-11-01

    The interaction of Eu(III) and Cm(III) with three different aquatic fulvic acids (FA) was studied as a function of the temperature (T = 20-80 °C) in 0.1 M NaCl solution by time-resolved laser fluorescence spectroscopy. The speciation of both trivalent metal ions was determined by peak deconvolution of the recorded fluorescence spectra. For each studied metal ion-FA system only one complexed species is formed under the given experimental conditions. The stability constants at 20, 40, 60 and 80 °C (log β'(T)) were determined according to the charge neutralization model. The log β' (20 °C) for the different FAs show similar values (log β(20 °C) = 5.60-6.29). The stability constants increase continuously with increasing temperature by approximately 0.3-1.0 orders of magnitude. The reaction enthalpies and entropies are derived from the integrated Van't Hoff equation. The results show that all investigated complexation reactions are endothermic and entropy-driven.

  7. Lanthanum(III) and Lutetium(III) in Nitrate-Based Ionic Liquids: A Theoretical Study of Their Coordination Shell.

    PubMed

    Bodo, Enrico

    2015-09-01

    By using ab initio molecular dynamics, we investigate the solvent shell structure of La(3+) and Lu(3+) ions immersed in two ionic liquids, ethylammonium nitrate (EAN) and its hydroxy derivative (2-ethanolammonium nitrate, HOEAN). We provide the first study of the coordination properties of these heavy metal ions in such a highly charged nonacqueous environment. We find, as expected, that the coordination in the liquid is mainly due to nitrate anions and that, due to the bidentate nature of the ligand, the complexation shell of the central ion has a nontrivial geometry and a coordination number in terms of nitrate molecules that apparently violates the decrease of ionic radii along the lanthanides series, since the smaller Lu(3+) ion seems to coordinate six nitrate molecules and the La(3+) ion only five. A closer inspection of the structural features obtained from our calculations shows, instead, that the first shell of oxygen atoms is more compact for Lu(3+) than for La(3+) and that the former coordinates 8 oxygen atoms while the latter 10 in accord with the typical lanthanide's trend along the series and that their first solvation shells have a slight irregular and complex geometrical pattern. When moving to the HOEAN solutions, we have found that the solvation of the central ion is possibly also due to the cation itself through the oxygen atom on the side chain. Also, in this liquid, the coordination numbers in terms of oxygen atoms in both solvents is 10 for La(3+) and 8 for Lu(3+).

  8. Theoretical and computational studies of plasma opening switches

    NASA Astrophysics Data System (ADS)

    Lindman, Erick L., Jr.; Kindel, Joseph M.

    1989-02-01

    Substantial progress has been made in understanding the operation of plasma opening switches (POS) in support of the Light-Ion Fusion Program at Sandia National Laboratories. Our efforts began with scoping studies using the particle-in-cell (PIC) code, MAGIC, which was written by Bruce Goplen and co-workers at MRC for pulsed-power applications. The version of MAGIC currently at Sandia National Laboratories is supported by Dave Seidel and Tim Pointon. MAGIC continues to play an important role as our studies moved into many different areas. Working closely with Cliff Mendel, we performed initial studies of switches using his fast B sub z concept. Working with Mary Ann Sweeney, Jeff Quintez and Cliff Mendel we performed studies of the effects of plasma density, cylindrical curvature, load impedance, rise time, and emission threshold on switch performance. In addition, we studied B-field penetration, turbulence, anomalous resistivity, and electron heating in plasma opening switches. This work has allowed us to identify the physical mechanisms that are important in the operation of plasma opening switches. Based on our knowledge of the physics we have established scaling relations for comparable switch performance under different experimental conditions. We studied the code requirements for POS simulation and numerical problems in MAGIC and in other PIC codes. And, more recently, we have begun to participate more strongly in the experimental program being carried out on PBFA II. Our conclusions based on these studies are summarized here.

  9. Theoretical and computational studies of plasma opening switches

    SciTech Connect

    Lindman, E.L. Jr.; Kindel, J.M.

    1989-02-01

    Substantial progress has been made in understanding the operation of plasma opening switches (POS) in support of the Light-Ion Fusion Program at Sandia National Laboratories. Our efforts began with scoping studies using the particle-in-cell (PIC) code, MAGIC, which was written by Bruce Goplen and co-workers at MRC for pulsed-power applications. The version of MAGIC currently at Sandia National Laboratories is supported by Dave Seidel and Tim Pointon. MAGIC continues to play an important role as our studies moved into many different areas. Working closely with Cliff Mendel, we performed initial studies of switches using his fast B/sub z/ concept. Working with Mary Ann Sweeney, Jeff Quintez and Cliff Mendel we performed studies of the effects of plasma density, cylindrical curvature, load impedance, rise time, and emission threshold on switch performance. In addition, we studied B-field penetration, turbulence, anomalous resistivity, and electron heating in plasma opening switches. This work has allowed us to identify the physical mechanisms that are important in the operation of plasma opening switches. Based on our knowledge of the physics we have established scaling relations for comparable switch performance under different experimental conditions. We studied the code requirements for POS simulation and numerical problems in MAGIC and in other PIC codes. And, more recently, we have begun to participate more strongly in the experimental program being carried out on PBFA II. Our conclusions based on these studies are summarized here. 42 refs., 104 figs., 3 tabs.

  10. Lanthanum(III) and Lutetium(III) in Nitrate-Based Ionic Liquids: A Theoretical Study of Their Coordination Shell.

    PubMed

    Bodo, Enrico

    2015-09-01

    By using ab initio molecular dynamics, we investigate the solvent shell structure of La(3+) and Lu(3+) ions immersed in two ionic liquids, ethylammonium nitrate (EAN) and its hydroxy derivative (2-ethanolammonium nitrate, HOEAN). We provide the first study of the coordination properties of these heavy metal ions in such a highly charged nonacqueous environment. We find, as expected, that the coordination in the liquid is mainly due to nitrate anions and that, due to the bidentate nature of the ligand, the complexation shell of the central ion has a nontrivial geometry and a coordination number in terms of nitrate molecules that apparently violates the decrease of ionic radii along the lanthanides series, since the smaller Lu(3+) ion seems to coordinate six nitrate molecules and the La(3+) ion only five. A closer inspection of the structural features obtained from our calculations shows, instead, that the first shell of oxygen atoms is more compact for Lu(3+) than for La(3+) and that the former coordinates 8 oxygen atoms while the latter 10 in accord with the typical lanthanide's trend along the series and that their first solvation shells have a slight irregular and complex geometrical pattern. When moving to the HOEAN solutions, we have found that the solvation of the central ion is possibly also due to the cation itself through the oxygen atom on the side chain. Also, in this liquid, the coordination numbers in terms of oxygen atoms in both solvents is 10 for La(3+) and 8 for Lu(3+). PMID:26291240

  11. A study on the properties and reactivity of naphthoquinone-cobalt(III) prototypes for bioreductive prodrugs.

    PubMed

    Bustamante, Francisco L S; Miranda, Fabio S; Castro, Frederico A V; Resende, Jackson A L C; Pereira, Marcos D; Lanznaster, Mauricio

    2014-03-01

    Our group has recently initiated a study on the development of new prototypes for bioreductive prodrugs, based on Co(III) complexes with the ligand 2,2'-bis(3-hydroxy-1,4-naphthoquinone), H2bhnq. The focus of this work is to investigate the dissociation of bhnq(-2) from the complex upon reduction, and the effects of pH, redox potential, oxygen concentration and nature of the auxiliary ligands on this reaction. The bhnq(2-) ligand is a "non-cytotoxic" agent that was chosen as a probe for the reactivity studies due to its suitable chromophoric properties, at the same time that it resembles more cytotoxic naphthoquinones relevant for cancer therapy. In this way, two Co(III) complexes [Co(bhnq)(L1)]BF4·H2O (1) and [Co(bhnq)(L2)]BF4·H2O (2) (L1=N,N'-bis(pyridin-2-ylmethyl)ethylenediamine and L2=N,N'-dimethyl-N,N'-bis(pyridin-2-ylmethyl)ethylenediamine) were synthesized and fully characterized. The gallium analogs [Ga(bhnq)(L1)]NO3·3H2O (3) and [Ga(bhnq)(L2)]NO3·3H2O (4) were also prepared for helping with the assignments of the redox properties of the cobalt complexes and the structure of 2. Cyclic voltammetry analysis revealed a pH-independent quasi-reversible Co(III)/Co(II) process at -0.22 and -0.08V vs NHE for 1 and 2, respectively. An O2-dependent dissociation of bhnq(2-) was observed for the reaction of 1 with ascorbic acid. For 2, the dissociation of bhnq(2-) was found to be independent on the concentration of O2 and faster than in 1, with little influence of the pH on both complexes. The difference in reactivity between 1 and 2 and their redox properties, among other factors, suggests that 1 undergoes redox cycling, pointed out as a key feature for a prodrug to achieve hypoxic selectivity.

  12. a Study of Erbium Doped Iii-V Semiconductors for Optoelectronic Applications

    NASA Astrophysics Data System (ADS)

    Sethi, Sanjay

    1995-11-01

    This dissertation presents work done on materials and novel devices made with MBE-grown Er-doped III-V semiconductors for optoelectronic applications. Optically-excited Er ^{3+} in insulating materials exhibits optical emission chiefly around 1.54 mum, in the range of minimum loss in silica fiber. It was thought, therefore, that an electrically -pumped Er-doped semiconductor laser would find great applicability in fiber-optic communication systems. Exhaustive photoluminescence (PL) characterization was conducted on the entire gamut of As-based III-V semiconductors doped with Er, on bulk as well as quantum-well structures. We did not observe any Er-related PL emission at 1.54 μm for any of the materials/structures studied, a phenomenon which renders impractical the realization of an Er-doped III-V semiconductor laser. Deep level transient spectroscopy studies were performed on GaAs and AlGaAs co-doped with Er and Si to investigate the presence of any Er-related deep levels. The lack of band-edge luminescence in the GaAs:Er films led us to perform carrier-lifetime measurements by electro-optic sampling of photoconductive transients generated in these films. We discovered lifetimes in the picosecond regime, tunable by varying the Er concentration in the films. We also found the films to be highly resistive, the resistivity increasing with increasing Er-concentration. Intensive structural characterization (Double -crystal X-ray and TEM) performed by us on GaAs:Er epilayers indicates the presence of high-density nanometer-sized ErAs precipitates in MBE-grown GaAs:Er. These metallic nanoprecipitates probably form internal Schottky barriers within the GaAs matrix, which give rise to Shockley-Read -Hall recombination centers, thus accounting for both the high resistivities and the ultrashort carrier lifetimes. Optoelectronic devices fabricated included novel tunable (in terms of speed and responsivity) high-speed metal-semiconductor-metal (MSM) photodiodes made with Ga

  13. Postoperative prophylactic hepatic arterial infusion chemotherapy for stage III colorectal cancer: a retrospective study

    PubMed Central

    Wang, Yao; Sun, Xin Rong; Feng, Wen Ming; Bao, Ying; Zheng, Yin Yuan

    2016-01-01

    Background Radical resection is the main treatment for colorectal cancer (CRC), but metastasis or recurrence is common in which liver metastasis accounted for 83% of the cases. Therefore, the prognosis of patients with advanced CRC may be improved if liver metastasis is prevented. This study aims to investigate the efficacy of hepatic arterial infusion chemotherapy (HAIC) on liver metastases of stage III CRC patients after curative resection. Methods Between 2002 and 2008, 287 stage III CRC patients who had undergone radical resection were included in this study. According to postoperative adjuvant chemotherapy modality, these patients were divided into two groups. Patients in the combined therapy group received two cycles of HAIC plus four cycles of systemic chemotherapy, while patients in the monotherapy group received six cycles of systemic chemotherapy alone. The HAIC regimen consisted of hepatic arterial infusion of oxaliplatin (OXA, 85 mg/m2) on day 1 and 5-fluorouracil (5-FU, 2,400 mg/m2) on days 2 and 3 followed by a vein infusion of folinic acid (FA, 200 mg/m2) as a 2-hour infusion on days 2 and 3. The systemic chemotherapy regimen consisted of a 2-hour infusion of OXA (85 mg/m2) on day 1 followed by FA (200 mg/m2) as a 2-hour infusion on days 2 and 3, and by 5-FU (2,400 mg/m2) as a 48-hour infusion. This was repeated every 4 weeks. All cases were followed up for 5 years or until death. The 5-year overall survival, disease-free survival, liver metastases-free survival, and the overall liver metastases rates were retrospectively compared. Results Significant differences were found in the 5-year overall survival (combined therapy, 70.71%; monotherapy, 57.14%; P=0.014), disease-free survival (combined therapy, 69.29%; monotherapy, 55.78%; P=0.021), and liver metastases-free survival rates (combined therapy, 70%; monotherapy, 56.46%; P=0.019). Conclusion Prophylactic adjuvant HAIC can prevent metachronous liver metastases and improve the prognosis of patients

  14. Synthesis, Physicochemical Properties, and Antimicrobial Studies of Iron (III) Complexes of Ciprofloxacin, Cloxacillin, and Amoxicillin

    PubMed Central

    Ajali, Uzoechi; Ukoha, Pius O.

    2014-01-01

    Iron (III) complexes of ciprofloxacin, amoxicillin, and cloxacillin were synthesized and their aqueous solubility profiles, relative stabilities, and antimicrobial properties were evaluated. The complexes showed improved aqueous solubility when compared to the corresponding ligands. Relative thermal and acid stabilities were determined spectrophotometrically and the results showed that the complexes have enhanced thermal and acid stabilities when compared to the pure ligands. Antimicrobial studies showed that the complexes have decreased activities against most of the tested microorganisms. Ciprofloxacin complex, however, showed almost the same activity as the corresponding ligand. Job's method of continuous variation suggested 1 : 2 metals to ligand stoichiometry for ciprofloxacin complex but 1 : 1 for cloxacillin complex. PMID:25505991

  15. Ab initio study on microscopic properties of III-V/water interfaces for photoelectrochemical hydrogen production

    NASA Astrophysics Data System (ADS)

    Wood, Brandon; Choi, Woon Ih; Schwegler, Eric; Ogitsu, Tadashi

    2013-03-01

    Photoelectrodes made of III-V semiconductors are known to exhibit very high solar-to-hydrogen conversion efficiency (from solar energy to chemical energy as H2 bond); however, photocorrosion of the electrode in electrolyte solution remains an issue. Based on ab-initio molecular dynamics simulations, we study the structure, stability, and chemical activity of GaP/InP(001) semiconductor electrodes in contact with water. We will show how surface oxygen and hydroxyl change the electronic and chemical properties of water at the interface, leading to the formation of a strong hydrogen-bond network where fast surface hydrogen transport seems to be realized. Implications from our findings will be discussed in detail at the presentation. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52- 07NA27344.

  16. Synthesis, structural characterization, luminescent properties and theoretical study of three novel lanthanide metal-organic frameworks of Ho(III), Gd(III) and Eu(III) with 2,5-thiophenedicarboxylate anion

    SciTech Connect

    Marques, Lippy F.; Correa, Charlane C.; Ribeiro, Sidney J.L.; Santos, Molíria V. dos; Dutra, José Diogo L.; Freire, Ricardo O.; Machado, Flávia C.

    2015-07-15

    In this paper, the synthesis of three new metal-organic frameworks of lanthanides (LnMOFs) ([Ln{sub 2}(2,5-tdc){sub 3}(dmso){sub 2}]·H{sub 2}O){sub n} (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. Crystal structure of (1) reveals that each lanthanide ion is seven-coordinated by oxygen atoms in an overall distorted capped trigonal – prismatic geometry. The 2,5-tdc{sup 2−} ligands connect four Ln(III) centers, adopting (κ{sup 1}–κ{sup 1})–(κ{sup 1}–κ{sup 1})–μ{sub 4} coordination mode, generating an 8-connected uninodal 3D network. In addition, theoretical studies for Eu(III) complex were performed using the Sparkle model for lanthanide complexes. - Graphical abstract: Three new metal-organic frameworks of lanthanides (LnMOFs) ([Ln{sub 2}(2,5-tdc){sub 3}(dmso){sub 2}]·H{sub 2}O){sub n} (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), were synthesized and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. - Highlights: • Three new LnMOFs were synthesized and fully characterized. • Ho{sup 3+}, Gd{sup 3+} and Eu{sup 3+} complexes photoluminescence properties were investigated. • Theoretical approaches for Eu{sup 3+} complex luminescence has been performed. • An energy level diagram is used to establish the ligand-to-metal energy transfer. • These metal−organic frameworks can act as light conversion molecular devices.

  17. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

    PubMed Central

    Ejidike, Ikechukwu P.

    2016-01-01

    Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)]. PMID:27597814

  18. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

    PubMed Central

    Ejidike, Ikechukwu P.

    2016-01-01

    Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)].

  19. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases.

    PubMed

    Ejidike, Ikechukwu P; Ajibade, Peter A

    2016-01-01

    Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N'-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)]. PMID:27597814

  20. A comparative study of the biosorption of iron(III)-cyanide complex anions to Rhizopus arrhizus and Chlorella vulgaris

    SciTech Connect

    Aksu, Z.; Calik, A.

    1999-03-01

    In this study a comparative biosorption of iron(III)-cyanide complex anions from aqueous solutions to Rhizopus arrhizus and Chlorella vulgaris was investigated. The iron(III)-cyanide complex ion-binding capacities of the biosorbents were shown as a function of initial pH, initial iron(III)-cyanide complex ion, and biosorbent concentrations. The results indicated that a significant reduction of iron(III)-cyanide complex ions was achieved at pH 13, a highly alkaline condition for both the biosorbents. The maximum loading capacities of the biosorbents were found to be 612.2 mg/g for R.arrhizus at 1,996.2 mg/L initial iron(III)-cyanide complex ion concentration and 387.0 mg/g for C. vulgaris at 845.4 mg/L initial iron(III)-cyanide complex ion concentration at this pH. The Freundlich, Langmuir, and Redlich-Peterson adsorption models were fitted to the equilibrium data at pH 3, 7, and 13. The equilibrium data of the biosorbents could be best fitted by all the adsorption models over the entire concentration range at pH 13.

  1. Study of adsorption of Neon on open Carbon nanohorns aggregates

    NASA Astrophysics Data System (ADS)

    Ziegler, Carl Andrew

    Adsorption isotherms can be used to determine surface area of a substrate and the heat released when adsorption occurs. Our measurements are done determining the equilibrium pressures corresponding to a given amount of gas adsorbed on a substrate at constant temperature. The adsorption studies were done on aggregates of open dahlia-like carbon nanohorns. The nanohorns were oxidized for 9 hours at 550 °C to open them up and render their interior space accessible for adsorption. Volumetric adsorption measurements of Ne were performed at twelve different temperatures between 19 K and 48 K. The isotherms showed two substeps. The first substep corresponds to adsorption on the high energy binding sites in the interior of the nanohorns, near the tip. The second substep corresponds to low energy binding sites both on the outside of the nanotubes and inside the nanotube away from the tip. The isosteric heat measurements obtained from the isotherm data also shows these two distinct substeps. The effective surface area of the open nanotubes was determined from the isotherms using the point-B method. The isosteric heat and surface area data for neon on open nanohorns were compared to two similar experiments of neon adsorbed on aggregates of closed nanohorns.

  2. TD-DFT study of the light-induced spin crossover of Fe(III) complexes.

    PubMed

    Saureu, Sergi; de Graaf, Coen

    2016-01-14

    Two light-induced spin-crossover Fe(III) compounds have been studied with time-dependent density functional theory (TD-DFT) to investigate the deactivation mechanism and the role of the ligand-field states as intermediates in this process. The B3LYP* functional has previously shown its ability to accurately describe (light-induced) spin-crossover in Fe(II) complexes. Here, we establish its performance for Fe(III) systems using [Fe(qsal)2](+) (Hqsal = 2-[(8-quinolinylimino)methyl]phenol) and [Fe(pap)2](+) (Hpap = 2-(2-pyridylmethyleneamino)phenol) as test cases comparing the B3LYP* results to experimental information and to multiconfigurational wave function results. In addition to rather accurate high spin (HS) and low spin (LS) state geometries, B3LYP* also predicts ligand-to-metal charge transfer (LMCT) states with large oscillator strength in the energy range where the UV-VIS spectrum shows an intense absorption band, whereas optically allowed π-π* excitations on the ligands were calculated at higher energy. Subsequently, we have generated a two-dimensional potential energy surface of the HS and LS states varying the Fe-N and Fe-O distances. LMCT and metal centered (MC) excited states were followed along the approximate minimal energy path that connects the minima of the HS and LS on this surface. The (2)LMCT state has a minimum in the same region as the initial LS state, where we also observe a crossing with the intermediate spin (IS) state. Upon the expansion of the coordination sphere of the Fe(III) ion, the IS state crosses with the HS state and further expansion of the coordination sphere leads to the excited spin state trapping as observed in experiment. The calculation of the intersystem crossing rates reveals that the deactivation from (2)LMCT → IS → HS competes with the (2)LMCT → IS → LS pathway, in line with the low efficiency encountered in experiments. PMID:26660866

  3. Trends in Ln(III) Sorption to Quartz Assessed by Molecular Dynamics Simulations and Laser Induced Flourescence Studies

    SciTech Connect

    Kuta, Jadwiga; Wander, Matthew C F.; Wang, Zheming; Jiang, Siduo; Wall, Nathalie; Clark, Aurora E.

    2011-11-08

    Molecular dynamics simulations were performed to examine trends in trivalent lanthanide [Ln(III)] sorption to quartz surface SiOH0 and SiO- sites across the 4f period. Complementary laser induced fluorescence studies examined Eu(III) sorption to quartz at varying ionic strength such that the surface sorbed species could be extrapolated at zero ionic strength, the conditions under which the simulations are performed. This allowed for direct comparison of the data, enabling a molecular understanding of the surface sorbed species and the role of the ion surface charge density upon the interfacial reactivity. Thus, this combined theoretical and experimental approach aids in the prediction of the fate of trivalent radioactive contaminants at temporary and permanent nuclear waste storage sites. Potential of mean force molecular dynamics, as well as simulations of pre-sorbed Ln(III) species agrees with the spectroscopic study of Eu(III) sorption, indicating that strongly bound inner-sphere complexes are formed upon sorption to an SiO- site. The coordination shell of the ion contains 6-7 waters of hydration and it is predicted that surface OH groups dissociate from the quartz and bind within the inner coordination shell of Eu(III). Molecular simulations predict less-strongly bound inner2 sphere species in early lanthanides and more strongly bound species in late lanthanides, following trends in the ionic radius of the 4f ions. The participation of surface dissociated OHgroups within the inner coordination shell of the Ln(III) ion is, however, consistent across the series studied. Sorption to a fully protonated quartz surface is not predicted to be favorable by any Ln(III), except perhaps Lu.

  4. Comparative studies of praseodymium(III) selective sensors based on newly synthesized Schiff's bases.

    PubMed

    Gupta, Vinod K; Goyal, Rajendra N; Pal, Manoj K; Sharma, Ram A

    2009-10-27

    Praseodymium ion selective polyvinyl chloride (PVC) membrane sensors, based on two new Schiff's bases 1,3-diphenylpropane-1,3-diylidenebis(azan-1-ylidene)diphenol (M(1)) and N,N'-bis(pyridoxylideneiminato) ethylene (M(2)) have been developed and studied. The sensor having membrane composition of PVC: o-NPOE: ionophore (M(1)): NaTPB (w/w; mg) of 150: 300: 8: 5 showed best performances in comparison to M(2) based membranes. The sensor based on (M(1)) exhibits the working concentration range 1.0x10(-8) to 1.0x10(-2) M with a detection limit of 5.0x10(-9) M and a Nernstian slope 20.0+/-0.3 mV decade(-1) of activity. It exhibited a quick response time as <8 s and its potential responses were pH independent across the range of 3.5-8.5. The influence of the membrane composition and possible interfering ions have also been investigated on the response properties of the electrode. The sensor has been found to work satisfactorily in partially non-aqueous media up to 15% (v/v) content of methanol, ethanol or acetonitrile and could be used for a period of 3 months. The selectivity coefficients determined by using fixed interference method (FIM) indicate high selectivity for praseodymium(III) ions over wide variety of other cations. To asses its analytical applicability the prepared sensor was successfully applied for determination of praseodymium(III) in spiked water samples.

  5. Cyclometalated gold(III) trioxadiborrin complexes: studies of the bonding and excited states.

    PubMed

    Ayoub, Nicholas A; Browne, Amberle R; Anderson, Bryce L; Gray, Thomas G

    2016-03-01

    Trioxadiborrins are chelating ligands that assemble in dehydration reactions of boronic acids. They are structurally related to β-diketonate ligands, but have a 2-charge. Little is known of the bonding properties of trioxadiborrin ligands. Presented here are density-functional theory (DFT) studies of cyclometalated gold(III) trioxadiborrins. Substituent effects are evaluated, and comparison is made to the cyclometalating 2-(4-tolyl)pyridine (tpy) ligand on gold. The tpy ligand binds more strongly than any trioxadiborrin ligand considered here, and the two ligands bind competitively to gold. The 1,3-diphenyl trioxadiborrin ligand of 1 has a larger absolute binding enthalpy to gold than its β-diketonate analogue. Conjugation between boron and aryl substituents delocalizes charge and attenuates the trioxadiborrin's binding capacity. Steric effects that disrupt conjugation between boron and aryl substituents cause the trioxadiborrin to chelate more tightly. Fragment bond orders are divided into in-plane and out-of-plane contributions for square planar 1. In-plane bonding accounts for 88% of bond order between (tpy)Au2+ and the trioxadiborrin ligand. Cyclometalated gold(III) trioxadiborrin complexes were previously shown to be phosphorescent. Spin-unrestricted triplet-state geometry optimizations find that the ten largest excited-state distortions all occur on the tpy ligand. A plot of spin density in triplet 1 shows spin to reside predominantly on tpy. The 77 K luminescence spectrum of 1 is reported here. Time-dependent DFT and configuration interaction singles calculations (corrected for doubles excitations) overestimate the emission energy by ∼ 0.12 eV. PMID:26821088

  6. Cyclometalated gold(III) trioxadiborrin complexes: studies of the bonding and excited states.

    PubMed

    Ayoub, Nicholas A; Browne, Amberle R; Anderson, Bryce L; Gray, Thomas G

    2016-03-01

    Trioxadiborrins are chelating ligands that assemble in dehydration reactions of boronic acids. They are structurally related to β-diketonate ligands, but have a 2-charge. Little is known of the bonding properties of trioxadiborrin ligands. Presented here are density-functional theory (DFT) studies of cyclometalated gold(III) trioxadiborrins. Substituent effects are evaluated, and comparison is made to the cyclometalating 2-(4-tolyl)pyridine (tpy) ligand on gold. The tpy ligand binds more strongly than any trioxadiborrin ligand considered here, and the two ligands bind competitively to gold. The 1,3-diphenyl trioxadiborrin ligand of 1 has a larger absolute binding enthalpy to gold than its β-diketonate analogue. Conjugation between boron and aryl substituents delocalizes charge and attenuates the trioxadiborrin's binding capacity. Steric effects that disrupt conjugation between boron and aryl substituents cause the trioxadiborrin to chelate more tightly. Fragment bond orders are divided into in-plane and out-of-plane contributions for square planar 1. In-plane bonding accounts for 88% of bond order between (tpy)Au2+ and the trioxadiborrin ligand. Cyclometalated gold(III) trioxadiborrin complexes were previously shown to be phosphorescent. Spin-unrestricted triplet-state geometry optimizations find that the ten largest excited-state distortions all occur on the tpy ligand. A plot of spin density in triplet 1 shows spin to reside predominantly on tpy. The 77 K luminescence spectrum of 1 is reported here. Time-dependent DFT and configuration interaction singles calculations (corrected for doubles excitations) overestimate the emission energy by ∼ 0.12 eV.

  7. A study of LNCFS III coal burners on boiler waterwall tube wastage

    SciTech Connect

    Abbott, R.C.; Gordon, C.M.; Saunders, M.M.; Bray, A.J.

    1996-07-01

    Ultrasonic Testing (UT) of waterwall tubing of a tangentially-fired, sub-critical boiler at Milliken Station of New York State Electric and Gas (NYSEG) was undertaken to determine the effects of the newly installed low NO{sub x} firing system on waterwall tube wastage. During a 1993 outage, the pulverized coal-fired boiler was equipped with an ABB CE Low NO, Concentric Firing System (LNCFS) of the third generation (III) including Staged Overfire Air (SOFA) and a coal pulverizing system capable of improving mill fineness by approximately 30 percent. The study was in conjunction with a Department of Energy Clean Coal Demonstration Project. Three separate thickness, surveys were compared using the Electric Power Research Institute`s (EPRI) Boiler Maintenance Workstation (BMW). The Tube Condition Module of BMW compared a total of 20,556 test locations of the three surveys. The evaluations of the surveys indicate that the short-term effect of low NO{sub x} firing with LNCFS III and increased fineness has moderately reduced the remaining life of the carbon steel boiler tubing in selected locations of the waterfall. Approximately 5 percent of the test locations are experiencing an annual tube wastage of 0.008 inches or greater. Additional testing and analyses are recommended to better understand the longer term effects of the low NO{sub x} firing system and the wastage of selected tubing The influence of boiler operating parameters, such as cyclic duty, proportioning of secondary air, or fuel changes, on waterwall tube wastage should also be evaluated over a longer operating period.

  8. Study of the Open Loop and Closed Loop Oscillator Techniques

    SciTech Connect

    Imel, George R.; Baker, Benjamin; Riley, Tony; Langbehn, Adam; Aryal, Harishchandra; Benzerga, M. Lamine

    2015-04-11

    This report presents the progress and completion of a five-year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques.The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this report we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems.

  9. Sorption of Eu(III) on granite: EPMA, LA-ICP-MS, batch and modeling studies.

    PubMed

    Fukushi, Keisuke; Hasegawa, Yusuke; Maeda, Koushi; Aoi, Yusuke; Tamura, Akihiro; Arai, Shoji; Yamamoto, Yuhei; Aosai, Daisuke; Mizuno, Takashi

    2013-11-19

    Eu(III) sorption on granite was assessed using combined microscopic and macroscopic approaches in neutral to acidic conditions where the mobility of Eu(III) is generally considered to be high. Polished thin sections of the granite were reacted with solutions containing 10 μM of Eu(III) and were analyzed using EPMA and LA-ICP-MS. On most of the biotite grains, Eu enrichment up to 6 wt % was observed. The Eu-enriched parts of biotite commonly lose K, which is the interlayer cation of biotite, indicating that the sorption mode of Eu(III) by the biotite is cation exchange in the interlayer. The distributions of Eu appeared along the original cracks of the biotite. Those occurrences indicate that the prior water-rock interaction along the cracks engendered modification of biotite to possess affinity to the Eu(III). Batch Eu(III) sorption experiments on granite and biotite powders were conducted as functions of pH, Eu(III) loading, and ionic strength. The macroscopic sorption behavior of biotite was consistent with that of granite. At pH > 4, there was little pH dependence but strong ionic strength dependence of Eu(III) sorption. At pH < 4, the sorption of Eu(III) abruptly decreased with decreased pH. The sorption behavior at pH > 4 was reproducible reasonably by the modeling considering single-site cation exchange reactions. The decrease of Eu(III) sorption at pH < 4 was explained by the occupation of exchangeable sites by dissolved cationic species such as Al and Fe from granite and biotite in low-pH conditions. Granites are complex mineral assemblages. However, the combined microscopic and macroscopic approaches revealed that elementary reactions by a single mineral phase can be representative of the bulk sorption reaction in complex mineral assemblages. PMID:24171426

  10. Sorption of Eu(III) on granite: EPMA, LA-ICP-MS, batch and modeling studies.

    PubMed

    Fukushi, Keisuke; Hasegawa, Yusuke; Maeda, Koushi; Aoi, Yusuke; Tamura, Akihiro; Arai, Shoji; Yamamoto, Yuhei; Aosai, Daisuke; Mizuno, Takashi

    2013-11-19

    Eu(III) sorption on granite was assessed using combined microscopic and macroscopic approaches in neutral to acidic conditions where the mobility of Eu(III) is generally considered to be high. Polished thin sections of the granite were reacted with solutions containing 10 μM of Eu(III) and were analyzed using EPMA and LA-ICP-MS. On most of the biotite grains, Eu enrichment up to 6 wt % was observed. The Eu-enriched parts of biotite commonly lose K, which is the interlayer cation of biotite, indicating that the sorption mode of Eu(III) by the biotite is cation exchange in the interlayer. The distributions of Eu appeared along the original cracks of the biotite. Those occurrences indicate that the prior water-rock interaction along the cracks engendered modification of biotite to possess affinity to the Eu(III). Batch Eu(III) sorption experiments on granite and biotite powders were conducted as functions of pH, Eu(III) loading, and ionic strength. The macroscopic sorption behavior of biotite was consistent with that of granite. At pH > 4, there was little pH dependence but strong ionic strength dependence of Eu(III) sorption. At pH < 4, the sorption of Eu(III) abruptly decreased with decreased pH. The sorption behavior at pH > 4 was reproducible reasonably by the modeling considering single-site cation exchange reactions. The decrease of Eu(III) sorption at pH < 4 was explained by the occupation of exchangeable sites by dissolved cationic species such as Al and Fe from granite and biotite in low-pH conditions. Granites are complex mineral assemblages. However, the combined microscopic and macroscopic approaches revealed that elementary reactions by a single mineral phase can be representative of the bulk sorption reaction in complex mineral assemblages.

  11. Phase I--II study of N4-behenoyl-1-beta-D-arabinofuranosylcytosine.

    PubMed

    Kimura, K; Yamada, K; Uzuka, Y; Maekawa, T; Takaku, F; Shimoyama, M; Ogawa, M; Amaki, I; Osamura, S; Ito, M; Sakai, Y; Oguro, M; Hattori, K; Hoshino, A; Hirota, Y; Ohta, K; Nakamura, T; Masaoka, T; Kimura, I; Ichimaru, M

    1981-01-01

    A phase I-II study of N4-behenoyl-1-beta-D-arabinofuranosyl-cytosine (BH-AC) was conducted by a cooperative study group. In phase I study, a total of 126 patients, 64 of whom had metastatic solid tumors and 62 of whom had leukemia, were administered BH-AC in a single IV dose at day 1 only or in daily IV doses for 3 to 21 days, with dose ranges of 1.5--10.0 mg/kg. Side effects included nausea and vomiting, which were significantly less in incidence and severity than those observed with ara-C. Myelosuppressive toxicity became severe with doses 3.6--5.0 mg/kg per day x 10 days. In phase II study, a total of 37 adult patients with acute leukemia were entered in the study. Responses were noted, with an overall rate of 35% complete remission. Of th 26 patients with AML, there were 13 CR. The recommended schedule of treatment for BH-AC, based on our data, is daily infusion of 4--5 mg/kg over 3 h for approximately 3 weeks. The results with BH-AC in patients with acute leukemia are superior to those which have been reported for ara-C.

  12. Complexation of Cm(III) and Eu(III) with a hydrophilic 2,6-bis(1,2,4-triazin-3-yl)-pyridine studied by time-resolved laser fluorescence spectroscopy.

    PubMed

    Ruff, Christian M; Müllich, Udo; Geist, Andreas; Panak, Petra J

    2012-12-28

    The complexation of Cm(III) and Eu(III) with 2,6-bis(5,6-di(sulfophenyl)-1,2,4-triazin-3-yl)pyridine (aq-BTP) is studied in water at pH 3.0 applying time-resolved laser fluorescence spectroscopy. With increasing ligand concentration [M(H(2)O)(9-3n)(aq-BTP)(n)] (M = Cm(III)/Eu(III), n = 1, 2, 3) complex species are spectroscopically identified. The conditional stability constants of the M(III) 1 : 3 complex species with aq-BTP are log β(03) = 12.2 for Cm(III) and log β(03) = 10.2 for Eu(III). The complexation reaction is enthalpy- and entropy-driven for both metal ions, while the enthalpy change ΔH(03) is 9.7 kJ mol(-1) more negative for Cm(III); changes in ΔS(03) are marginal. The difference in ΔG(03) of -12.7 kJ mol(-1) between the formation of the [M(aq-BTP)(3)] complexes agrees with aq-BTP's selectivity in liquid-liquid extraction studies. PMID:23018544

  13. Complexation of Cm(III) and Eu(III) with a hydrophilic 2,6-bis(1,2,4-triazin-3-yl)-pyridine studied by time-resolved laser fluorescence spectroscopy.

    PubMed

    Ruff, Christian M; Müllich, Udo; Geist, Andreas; Panak, Petra J

    2012-12-28

    The complexation of Cm(III) and Eu(III) with 2,6-bis(5,6-di(sulfophenyl)-1,2,4-triazin-3-yl)pyridine (aq-BTP) is studied in water at pH 3.0 applying time-resolved laser fluorescence spectroscopy. With increasing ligand concentration [M(H(2)O)(9-3n)(aq-BTP)(n)] (M = Cm(III)/Eu(III), n = 1, 2, 3) complex species are spectroscopically identified. The conditional stability constants of the M(III) 1 : 3 complex species with aq-BTP are log β(03) = 12.2 for Cm(III) and log β(03) = 10.2 for Eu(III). The complexation reaction is enthalpy- and entropy-driven for both metal ions, while the enthalpy change ΔH(03) is 9.7 kJ mol(-1) more negative for Cm(III); changes in ΔS(03) are marginal. The difference in ΔG(03) of -12.7 kJ mol(-1) between the formation of the [M(aq-BTP)(3)] complexes agrees with aq-BTP's selectivity in liquid-liquid extraction studies.

  14. Can anisotropic exchange be reliably calculated using density functional methods? A case study on trinuclear Mn(III)-M(III)-Mn(III) (M=Fe, Ru, and Os) cyanometalate single-molecule magnets.

    PubMed

    Singh, Saurabh Kumar; Rajaraman, Gopalan

    2014-01-01

    Density functional studies have been performed on a set of trinuclear single-molecule magnets (SMMs) of general formula [{Mn2(5-Br salen)2(MeOH)2}M(CN)6](NEt4) (M=Fe(III) (1), Ru(III) (2) and Os(III) (3); 5-Brsalen=N,N'-ethylenebis(5-bromosalicylidene)iminato anion). We have computed the orbital-dependent exchange interaction for all three complexes for the first time using DFT and complete active space self-consistent field (CASSCF) methods. DFT calculations yield the anisotropic exchange as J(ξξ)=3.5 cm(-1) for 1; J(ξξ)=12.1 cm(-1), J(ζζ)=-6.9 cm(-1) and J(ηη)=-14 cm(-1) for 2; and J(ξξ)=23.7 cm(-1) and J(ζζ) =-11.1 cm(-1) for 3. The computed values are in agreement with the experimental report, and this suggests that the established methodology can be used to compute the anisotropic exchange in larger clusters. Our calculations reiterate the fact that the exchange is described by a three-axis anisotropic exchange for complexes 2 and 3 as evidenced by the experiments. A stronger exchange coupling as we move down the periodic table from 3d to 5d is reproduced by our calculations, and the origin of this enhancement in the exchange interaction has been probed by using molecular orbital analysis. The electronic origin of different types of exchange observed in this series is found to be related to the energy difference between possible degenerate pairs and the nature of orbital interactions. By computing the exchange interaction, the single-ion anisotropy of Mn(III) and zero-field splitting of the S=9/2 ground state of complexes 1-3 using CASSCF and/or DFT methods, we have attempted to shed light on the issue of anisotropic exchange and the barrier height for the magnetisation reversal in SMMs. Comprehensive magneto-structural correlations have been developed to offer clues on how to further enhance the barrier height in this class of SMMs. PMID:24288194

  15. Synthesis, characterization, antiproliferative and molecular docking study of new half sandwich Ir(III), Rh(III) and Ru(II) complexes.

    PubMed

    Thangavel, Saravanan; Paulpandi, Manickam; Friedrich, Holger B; Murugan, Kadarkarai; Kalva, Sukesh; Skelton, Adam A

    2016-06-01

    The new carbazole N,N' ligand containing [(η(5)-C5Me5)MCl(L)]PF6, (M=Ir (1) and Rh (2)) and [(η(6)-C6H6)RuCl(L)]PF6 (3) (C5Me5=pentamethylcyclopentadienyl, L=9-ethyl-N-(pyridine-2-yl methylene)-9H-carbazole-3-amine) complexes has been synthesized and characterized by (1)H NMR, (13)C NMR, 2D NMR, melting point analysis, electronic absorption, infrared spectroscopy, HR-Mass spectroscopy and elemental analyses. The crystal structure of the [(η(5)-C5Me5)RhCl(L)]PF6 has been confirmed by single crystal XRD. The anticancer study of the synthesized complexes 1-3 clearly showed a potent inhibitor of human breast cancer cells (MCF-7) under in vitro conditions. The inhibitory concentrations (IC50) of the complexes 1-3 were determined at low (5, 6 and 8μM) concentration against the MCF-7 human breast cancer cell line. Further cytotoxic, cell cycle and nuclear studies confirmed that the novel half sandwich Ir(III), Rh(III) and Ru(II) complexes could be effective against MCF-7 human breast cancer cell proliferation. Moreover the results indicate that anticancer in vitro activity of complexes 1-3 falls in the order of 1>2>3. A molecular docking study of the complexes 1-3 showed the nature of binding energy, H-bond and hydrophobic interactions with the cyclooxygenase-2 (COX-2) receptor. PMID:26918899

  16. Fluorescence studies, DNA binding properties and antimicrobial activity of a dysprosium(III) complex containing 1,10-phenanthroline.

    PubMed

    Khorasani-Motlagh, Mozhgan; Noroozifar, Meissam; Moodi, Asieh; Niroomand, Sona

    2013-10-01

    Luminescence and binding properties of dysprosium(III) complex containing 1,10-phenanthroline (phen), [Dy(phen)2(OH2)3Cl]Cl2⋅H2O with DNA has been studied by electronic absorption, emission spectroscopy and viscosity measurement. The thermodynamic studies suggest that the interaction process to be endothermic and entropically driven, which indicates that the dysprosium(III) complex might interact with DNA by a non intercalation binding mode. Additionally, the competitive fluorescence study with ethidium bromide and also the effect of iodide ion and salt concentration on fluorescence of the complex-DNA system is investigated. Experimental results indicate that the Dy(III) complex strongly binds to DNA, presumably via groove binding mode. Furthermore, the complex shows a potent antibacterial activity and DNA cleavage ability.

  17. Study on the interaction of Co (III) DiAmsar with serum albumins: Spectroscopic and molecular docking methods

    NASA Astrophysics Data System (ADS)

    Farahani, Bahman Vasheghani; Bardajee, Ghasem Rezanejade; Rajabi, Farzaneh Hosseinpour; Hooshyar, Zari

    2015-01-01

    This study was designed to examine the interaction of cobalt-3,6,10,13,16,19-hexaazabicyclo[6.6.6]eicosane-1,8-diamine (Co(III) DiAmsar) as a hexadentate ligand with human serum albumin (HSA) and bovine serum albumin (BSA) under physiological conditions in Tris-HCl buffer solution at pH 7.4. To this aim, at first, Co (III) DiAmsar was synthesized and characterized by nuclear magnetic resonance (NMR), and mass spectroscopy and then its interaction with HSA and BSA was investigated by means of various spectroscopic methods (Fourier transform infrared (FT-IR), UV-visible (UV-vis), fluorescence, and cyclic voltammetry (CV)) and molecular docking technique. The results of fluorescence titration revealed that the Co (III) DiAmsar strongly quench the intrinsic fluorescence of HSA and BSA through a static quenching procedure. Binding constants (Ka) and the number of binding sites (n ∼ 1) were calculated using Stern-Volmer equations. The ΔG parameters at different temperatures were calculated. Subsequently, the values of ΔH and ΔS were also calculated, which revealed that the van der Waals and hydrogen bonding interaction splay a major role in Co (III) DiAmsar-HSA and Co (III) DiAmsar-BSA associations. The distance r between donor (HSA and BSA) and acceptor (Co (III) DiAmsar) was obtained according to fluorescence resonance energy transfer. The data obtained by the molecular modeling study revealed the surrounding residues of HSA and BSA around Co (III) DiAmsar.

  18. Cross-sectional retrospective study of muscle function in patients with glycogen storage disease type III.

    PubMed

    Decostre, Valérie; Laforêt, Pascal; Nadaj-Pakleza, Aleksandra; De Antonio, Marie; Leveugle, Sylvain; Ollivier, Gwenn; Canal, Aurélie; Kachetel, Kahina; Petit, François; Eymard, Bruno; Behin, Anthony; Wahbi, Karim; Labrune, Philippe; Hogrel, Jean-Yves

    2016-09-01

    Glycogen storage disease type III is an inherited metabolic disorder characterized by liver and muscle impairment. This study aimed to identify promising muscle function measures for future studies on natural disease progression and therapeutic trials. The age-effect on the manual muscle testing (MMT), the hand-held dynamometry (HHD), the motor function measure (MFM) and the Purdue pegboard test was evaluated by regression analysis in a cross-sectional retrospective single site study. In patients aged between 13 and 56 years old, the Purdue pegboard test and dynamometry of key pinch and knee extension strength were age-sensitive with annual losses of 1.49, 1.10 and 0.70% of the predicted values (%pred), respectively. The MFM score and handgrip strength were also age-sensitive but only in patients older than 29 and 37 years old with annual losses of 1.42 and 1.84%pred, respectively. Muscle strength assessed by MMT and elbow extension measured by HHD demonstrated an annual loss of less than 0.50%pred and are thus unlikely to be promising outcome measures for future clinical trials. In conclusion, our results identified age-sensitive outcomes from retrospective data and may serve for future longitudinal studies in which an estimation of the minimal number of subjects is provided.

  19. Study of Intermediate Age (~10-30 Myr) Open Clusters

    NASA Astrophysics Data System (ADS)

    Olguin, Lorenzo; Michel, Raul; Contreras, Maria; Hernandez, Jesus; Schuster, William; Chavarria-Kleinhenn, Carlos

    2013-07-01

    We present the study of a sample of intermediate age open clusters (age ~ 10-30 Myr) using optical (UBVRI) and infrared photometric data. Optical photometry was obtained as part of the San Pedro Martir Open Clusters Project (SPM-OCP, Schuster et al. 2007; Michel et al. 2013). Infrared photometry was retrieved from 2MASS public data archive and WISE database. Open clusters included in the SPM-OCP were selected from catalogues presented by Dias et al. (2002) and Froebrich, Scholz & Raftery (2007). One of the main goals of the SPM-OCP is to compile a self-consistent and homogeneous set of cluster fundamental parameters such as reddening, distance, age, and metallicity whenever possible. In this work, we have analyzed a set of 25 clusters from the SPM-OCP with estimated ages between 10 and 30 Myr. Derived fundamental parameters for each cluster in the sample as well as an example of typical color-color and color-magnitude diagrams are presented. Kinematic membership was established by using proper motion data taken from the literature. Based on infrared photometry, we have searched for candidate stars to posses a circumstellar disk within each clusters. For those selected candidates a follow-up spectroscpic study is being carried out. This work was partially supported by UNAM-PAPIIT grant IN-109311.

  20. Anthem simulational studies of the plasma opening switch

    SciTech Connect

    Mason, R.J.

    1992-01-01

    For a deeper understanding of the physical processes governing the Plasma Opening Switch (POS) we use the ANTHEM 2D implicit simulation code to study: (1) ion dynamical effects on electrohydrodynamic (EHD) waves propagating along steep density interfaces in the switch plasmas. At radial interfaces where the density jumps toward the anode, these waves can drive a finger of magnetic field into the plasma toward the load. Ion dynamics can open the rear of such fingers into a wedge-like density gap. Then: (2) we examine ion effects in uniform switch plasmas. These first develop potential hill structures at the drive edge of the cathode from the competition between electron velocity advection and EHD magnetic exclusion waves. Magnetic pressure gradients at the hill periphery and EHD effects then establish a density gap propagating along the cathode with radial electron emission from its tip. Similar results are obtained under both multi-fluid and PIC modeling of the plasma components.

  1. Anthem simulational studies of the plasma opening switch

    SciTech Connect

    Mason, R.J.

    1992-07-01

    For a deeper understanding of the physical processes governing the Plasma Opening Switch (POS) we use the ANTHEM 2D implicit simulation code to study: (1) ion dynamical effects on electrohydrodynamic (EHD) waves propagating along steep density interfaces in the switch plasmas. At radial interfaces where the density jumps toward the anode, these waves can drive a finger of magnetic field into the plasma toward the load. Ion dynamics can open the rear of such fingers into a wedge-like density gap. Then: (2) we examine ion effects in uniform switch plasmas. These first develop potential hill structures at the drive edge of the cathode from the competition between electron velocity advection and EHD magnetic exclusion waves. Magnetic pressure gradients at the hill periphery and EHD effects then establish a density gap propagating along the cathode with radial electron emission from its tip. Similar results are obtained under both multi-fluid and PIC modeling of the plasma components.

  2. Study of the radon released from open drill holes

    SciTech Connect

    Pacer, J C

    1981-06-01

    The radon emanating from three open drill holes was measured at a site of known uranium mineralization in the Red Desert of south central Wyoming. The radon flux from the soil and drill holes was measured by the accumulator method with activated charcoal cartridges. The surface soil was found to release radon at an average rate of 0.41 atoms/cm/sup 2//sec; the radon emanating from the holes was more variable than that from the soil. The three holes studied released an average of 47 atoms/cm/sup 2//sec of radon. This average is equivalent to the radon released to the atmosphere by 14.5 ft/sup 2/ of soil. The data indicate that the radon emanated from an open drill hole is not as significant as other possible activities at a drill site (i.e. digging a trench or drilling a hole) or from household activities involving the usage of water.

  3. Clinical and radiological results after coracoclavicular ligament reconstruction for type III acromioclavicular joint dislocation using three different techniques. A retrospective study

    PubMed Central

    VASCELLARI, ALBERTO; SCHIAVETTI, STEFANO; BATTISTELLA, GIUSEPPE; REBUZZI, ENRICO; COLETTI, NICOLÒ

    2015-01-01

    Purpose the purpose of this retrospective study was to present the outcomes of three different techniques for the treatment of type III acromioclavicular joint dislocations: arthroscopic TightRope (TR), arthroscopic GraftRope (GR), and open reconstruction of the coracoclavicular (CC) ligament using the Ligament Augmentation and Reconstruction System (LARS). Methods eighteen patients underwent clinical and radiological evaluations after a mean follow-up time of 43 months. The following clinical outcome measures were considered: the Disability of the Arm, Shoulder and Hand outcome measure (DASH), the Nottingham Clavicle Score (NCS), and the Constant score (CS). On X-rays, the CC distance was measured. Results the median DASH score at follow-up was 12.5 in the TR group, 5 in the GR group, and 4.2 in the LARS group. The median NCS value was 88 in the TR group, 88 in the GR group, and 91 in the LARS group. The median CS was 100 in the TR group, 95 in the GR group, and 94.5 in the LARS group. The mean CC distance was 10.3 mm in the TR group, 13.8 in the GR group, and 16.6 in the LARS group. Conclusions all three techniques proved to be reliable in providing good clinical outcomes, although none of the studied techniques demonstrated reliability in maintaining anatomical reduction after surgery. Level of evidence Level III, retrospective comparative study. PMID:26605251

  4. Effect of phosphate, silicate, and Ca on Fe(III)-precipitates formed in aerated Fe(II)- and As(III)-containing water studied by X-ray absorption spectroscopy

    NASA Astrophysics Data System (ADS)

    Voegelin, Andreas; Kaegi, Ralf; Frommer, Jakob; Vantelon, Delphine; Hug, Stephan J.

    2010-01-01

    We studied the local coordination and structure of Fe(III)-precipitates formed in aerated Fe(II)- and As(III)-containing water (buffered to pH 7 by 8 mM bicarbonate) using synchrotron-based X-ray absorption spectroscopy (XAS) at the K-edges of Fe, P, Ca, and As. Dissolved phosphate, silicate, and Ca at different ratios relative to each other and to Fe affect the forming Fe(III)-phases in a complex manner. The high affinity of phosphate for Fe(III) results in the predominant precipitation of Fe(III)-phosphate as long as dissolved phosphate is present, with Fe(III) polymerization limited to small oligomers. In Ca-containing solution, Ca uptake by Fe(III)-Ca-phosphate involves the linkage and coagulation of negatively charged Fe(III)-phosphate oligomers via Ca-O-P bonds. In the absence of phosphate, dissolved silicate at Si/Fe ratios above ˜0.5 results in the formation of hydrous ferric oxide (HFO) with mainly edge-sharing Fe-Fe linkage. At lower Si/Fe ratios of ˜0.5-0.1, mainly 2-line ferrihydrite (2L-Fh) with both edge- and corner-sharing Fe-Fe linkage forms. Only in the absence of phosphate at low Si/Fe ratio, lepidocrocite (Lp) forms. In solutions containing sufficient Fe(II), aeration results in the sequential precipitation of Fe(III)-(Ca-)phosphate, HFO or 2L-Fh (depending on solution Si/Fe), and finally Lp. The amount and oxidation state of As co-precipitated with Fe(III) are controlled by the co-oxidation of As(III) with Fe(II), which increases with initial Fe/As ratio, and the competitive uptake of phosphate, As(V) and less strongly sorbing silicate and As(III). This study demonstrates that the diversity and sequence of short-range-ordered Fe(III)-precipitates forming by Fe(II) oxidation in near-neutral natural waters depend on water chemistry. Because differences in the colloidal stability and biogeochemical reactivity of these phases will affect the fate of associated major and trace elements, the different Fe(III)-precipitates and their specific

  5. Antioxidant, tautomerism and antibacterial studies of Fe(III)-1,2,4-triazole based complexes

    NASA Astrophysics Data System (ADS)

    Kharadi, G. J.

    2013-06-01

    New Fe(III) complexes have been synthesized by the reactions of ferric nitrate with Schiff base derived from 3-substituted phenyl-4-amino-5-hydrazino-1,2,4-triazole and indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [FeLn(H2O)(OH)]·xH2O. Structural and spectroscopic properties have been studied on the basis of elemental analyses, infrared spectra, 1H and 13H NMR spectra, electronic spectra, magnetic measurements and FAB mass spectra. FT-IR, 1H and 13H NMR studies reveal that the ligand (Ln) exists in the tautomeric enol form in both the states with intramolecular hydrogen bonding. Magnetic moment and reflectance spectral studies reveal that an octahedral geometry has been assigned to all the prepared complexes. FRAP values indicate that all the compounds have a ferric reducing antioxidant power. The compounds 2 and 3 showed relatively high antioxidant activity while compound 1 and 4 shows poor antioxidant power. Also good antimicrobial activities of the complexes against Staphylococcus aureus, Bacillus subtilis, Serratia marcescens, Pseudomonas aeruginosa and Escherichia coli have been found compared to its free ligands.

  6. A Study of Open Entry-Open Exit Programs in Vocational Education. Institutional Research Report No. 78/79-6.

    ERIC Educational Resources Information Center

    Ferguson, R. Travis

    A study was conducted at Mississippi Gulf Coast Junior College to determine the viability of open entry-open exit enrollment in vocational programs. Interviews were conducted with vocational education personnel at two campuses to determine the fulfillment of student objectives, drop-out rates, and graduate job placement in five programs (auto…

  7. Study of As(III) and As(V) Oxoanion Adsorption onto Single and Mixed Ferrite and Hausmannite Nanomaterials

    PubMed Central

    Garcia, Sandra; Sardar, Saima; Maldonado, Stephanie; Garcia, Velia; Tamez, C.; Parsons, J. G.

    2014-01-01

    The removal of arsenic(III) and arsenic(V) from an aqueous solution through adsorption on to Fe3O4, MnFe2O4, 50% Mn substituted Fe3O4, 75% Mn substituted Fe3O4, and Mn3O4 nanomaterials was investigated. Characterization of the nanomaterials using XRD showed only pure phases for Mn3O4, MnFe2O4, and Fe3O4. The 50% and 75% substituted nanomaterials were found to be mixtures of Mn3O4 and Fe3O4. From batch studies the optimum binding pH of arsenic(III) and arsenic(V) to the nanomaterials was determined to be pH 3. The binding capacity for As(III) and As(VI) to the various nanomaterials was determined using Isotherm studies. The binding capacity of Fe3O4 was determined to be 17.1 mg/g for arsenic(III) and 7.0 mg/g for arsenic(V). The substitution of 25% Mn into the Fe3O4 lattice showed a slight increase in the binding capacity for As(III) and As(VI) to 23.8 mg/g and 7.9 mg/g, respectively. The 50% substituted showed the maximum binding capacity of 41.5 mg/g and 13.9 mg/g for arsenic(III) and arsenic(V). The 75% Mn substituted Fe3O4 capacities were 16.7 mg/g for arsenic(III) and 8.2 mg/g for arsenic(V). The binding capacity of the Mn3O4 was determined to be 13.5 mg/g for arsenic(III) and 7.5 mg/g for arsenic(V). In addition, interference studies on the effects of SO2−4, PO3−4, Cl−, and NO−3 investigated. All the interferences had very minimal effects on the As(III) and As(V) binding never fell below 20% even in the presence of 1000 ppm interfering ions. PMID:25097269

  8. Potentiometric and ³¹P NMR studies on inositol phosphates and their interaction with iron(III) ions.

    PubMed

    Sala, Martin; Makuc, Damjan; Kolar, Jana; Plavec, Janez; Pihlar, Boris

    2011-03-01

    Potentiometric, conductometric and ³¹P NMR titrations have been applied to study interactions between myo-inositol hexakisphosphate (phytic acid), (±)-myo-inositol 1,2,3,5-tetrakisphosphate and (±)-myo-inositol 1,2,3-trisphosphate with iron(III) ions. Potentiometric and conductometric titrations of myo-inositol phosphates show that addition of iron increases acidity and consumption of hydroxide titrant. By increasing the Fe(III)/InsP(6) ratio (from 0.5 to 4) 3 mol of protons are released per 2 mol of iron(III). At first, phytates coordinate iron octahedrally between P2 and P1,3. The second coordination site represents P5 and neighbouring P4,6 phosphate groups. Complexation is accompanied with the deprotonation of P1,3 and P4,6 phosphate oxygens. At higher concentration of iron(III) intermolecular P-O-Fe-O-P bonds trigger formation of a polymeric network and precipitation of the amorphous Fe(III)-InsP(6) aggregates. (31)P NMR titration data complement the above results and display the largest chemical shift changes at pD values between 5 and 10 in agreement with strong interactions between iron and myo-inositol phosphates. The differences in T(1) relaxation times of phosphorous atoms have shown that phosphate groups at positions 1, 2 and 3 are complexated with iron(III). The interactions between iron(III) ions and inositol phosphates depend significantly on the metal to ligand ratio and an attempt to coordinate more than two irons per InsP(6) molecule results in an unstable heterogeneous system.

  9. Open source projects in software engineering education: a mapping study

    NASA Astrophysics Data System (ADS)

    Nascimento, Debora M. C.; Almeida Bittencourt, Roberto; Chavez, Christina

    2015-01-01

    Context: It is common practice in academia to have students work with "toy" projects in software engineering (SE) courses. One way to make such courses more realistic and reduce the gap between academic courses and industry needs is getting students involved in open source projects (OSP) with faculty supervision. Objective: This study aims to summarize the literature on how OSP have been used to facilitate students' learning of SE. Method: A systematic mapping study was undertaken by identifying, filtering and classifying primary studies using a predefined strategy. Results: 72 papers were selected and classified. The main results were: (a) most studies focused on comprehensive SE courses, although some dealt with specific areas; (b) the most prevalent approach was the traditional project method; (c) studies' general goals were: learning SE concepts and principles by using OSP, learning open source software or both; (d) most studies tried out ideas in regular courses within the curriculum; (e) in general, students had to work with predefined projects; (f) there was a balance between approaches where instructors had either inside control or no control on the activities performed by students; (g) when learning was assessed, software artefacts, reports and presentations were the main instruments used by teachers, while surveys were widely used for students' self-assessment; (h) most studies were published in the last seven years. Conclusions: The resulting map gives an overview of the existing initiatives in this context and shows gaps where further research can be pursued.

  10. A Study of Innovative Features in Scholarly Open Access Journals

    PubMed Central

    2011-01-01

    Background The emergence of the Internet has triggered tremendous changes in the publication of scientific peer-reviewed journals. Today, journals are usually available in parallel electronic versions, but the way the peer-review process works, the look of articles and journals, and the rigid and slow publication schedules have remained largely unchanged, at least for the vast majority of subscription-based journals. Those publishing firms and scholarly publishers who have chosen the more radical option of open access (OA), in which the content of journals is freely accessible to anybody with Internet connectivity, have had a much bigger degree of freedom to experiment with innovations. Objective The objective was to study how open access journals have experimented with innovations concerning ways of organizing the peer review, the format of journals and articles, new interactive and media formats, and novel publishing revenue models. Methods The features of 24 open access journals were studied. The journals were chosen in a nonrandom manner from the approximately 7000 existing OA journals based on available information about interesting journals and include both representative cases and highly innovative outlier cases. Results Most early OA journals in the 1990s were founded by individual scholars and used a business model based on voluntary work close in spirit to open-source development of software. In the next wave, many long-established journals, in particular society journals and journals from regions such as Latin America, made their articles OA when they started publishing parallel electronic versions. From about 2002 on, newly founded professional OA publishing firms using article-processing charges to fund their operations have emerged. Over the years, there have been several experiments with new forms of peer review, media enhancements, and the inclusion of structured data sets with articles. In recent years, the growth of OA publishing has also been

  11. A computer simulation study of type III radio burst propagation through the solar corona

    NASA Astrophysics Data System (ADS)

    Itkina, M. A.; Levin, B. N.

    1992-01-01

    Type III solar radio burst propagation through large-scale coronal structure is numerically simulated. It is shown that radio wave refraction in an overdense streamer results in an increase of the apparent radial distance of the type III fundamental source and produces a broadening of the radiation polar diagram in agreement with the observations. It is also verified that the well-known fine frequency structure of type IIIb emission can be due to the fibrous character of the streamer.

  12. The Heartmate III: design and in vivo studies of a maglev centrifugal left ventricular assist device.

    PubMed

    Loree, H M; Bourque, K; Gernes, D B; Richardson, J S; Poirier, V L; Barletta, N; Fleischli, A; Foiera, G; Gempp, T M; Schoeb, R; Litwak, K N; Akimoto, T; Kameneva, M; Watach, M J; Litwak, P

    2001-05-01

    A compact implantable centrifugal left ventricular assist device (LVAD) (HeartMate III) featuring a magnetically levitated impeller is under development. The goal of our ongoing work is to demonstrate feasibility, low hemolysis, and low thrombogenicity of the titanium pump in chronic bovine in vivo studies. The LVAD is based on so-called bearingless motor technology and combines pump rotor, drive, and magnetic bearing functions in a single unit. The impeller is rotated (theta z) and levitated with both active (X, Y) and passive (Z, theta x, theta y) suspension. Six prototype systems have been built featuring an implantable titanium pump (69 mm diameter, 30 mm height) with textured blood contacting surfaces and extracorporeal electronics. The pumps were implanted in 9 calves (< or = 100 kg at implant) that were anticoagulated with Coumadin (2.5 < or = INR < or = 4.0) throughout the studies. Six studies were electively terminated (at 27-61 days), 1 study was terminated after the development of severe pneumonia and lung atelectasis (at 27 days) another study was terminated after cardiac arrest (at 2 days) while a final study is ongoing (at approximately 100 days). Mean pump flows ranged from 2 to 7 L/min, except for brief periods of exercise at 6 to 9 L/min. Plasma free hemoglobin ranged from 4 to 10 mg/dl. All measured biochemical indicators of end organ function remained within normal range. The pumps have met performance requirements in all 9 implants with acceptable hemolysis and no mechanical failures. PMID:11403669

  13. Spectroscopic studies on the interaction between tryptophan-erbium(III) complex and herring sperm DNA.

    PubMed

    Zhao, Na; Wang, Xingming; Pan, Haizhuan; Hu, Yamin; Ding, Lisheng

    2010-05-01

    By means of UV and fluorescence spectra, the binding ratios between Er(III)-Trp and DNA in physiological pH environment (pH 7.40) were determined as n(Trp):n(Er(III))=3:1 and (n)ER(III)(Trp)(3):(n)(DNA) = 2:1, and the apparent molar absorptivity of epsilon(Er(III)-Trp-DNA) is 4.33 x 10(5) L mol(-1)cm(-1) which was confirmed by molar ratio method. The binding constants at different temperatures K(B25 degrees C)(theta)=1.93 x 10(4)L mol(-1) and K(B37 degrees C)(theta)=5.28 x 10(3)L mol(-1) were obtained by double reciprocal method. Thermodynamic function computation demonstrates that Delta(r)H(m)(theta) is the primary driving power of the interaction between Er(III)(Trp)(3) and DNA. By combination analysis of the Scatchard method and CD spectrometry, we suggested that the interaction mode between Er(III)(Trp)(3) complex and herring sperm DNA is groove and intercalation bindings.

  14. Statistical study of the correlation of hard X-ray and type III radio bursts in solar flares

    NASA Technical Reports Server (NTRS)

    Hamilton, Russell J.; Petrosian, Vahe; Benz, A. O.

    1990-01-01

    A large number of hard X-ray events which occurred during the maximum of solar cycle 21 have been analyzed in order to study their correlation with type III bursts. It is found that the distribution of occurrences of hard X-ray bursts correlated with type III radio bursts is significantly different from the distribution of all hard X-ray bursts. This result is consistent with the assumption that the hard X-ray and type III intensities are somewhat correlated. A bivariate distribution function of the burst intensities is fitted to the data and is used to determine that the typical ratio of X-ray intensity to type II intensity is about 10 and that the ratio of the number of X-ray producing-electrons to type III-producing electrons is about 1000. Three models which have been proposed to explain the relation between the accelerated hard X-ray and type III-producing electrons are examined in the context of these observations.

  15. Statistical study of the correlation of hard X-ray and type III radio bursts in solar flares

    SciTech Connect

    Hamilton, R.J.; Petrosian, V.; Benz, A.O. Zuerich Eidgenoessische Technische Hochschule )

    1990-08-01

    A large number of hard X-ray events which occurred during the maximum of solar cycle 21 have been analyzed in order to study their correlation with type III bursts. It is found that the distribution of occurrences of hard X-ray bursts correlated with type III radio bursts is significantly different from the distribution of all hard X-ray bursts. This result is consistent with the assumption that the hard X-ray and type III intensities are somewhat correlated. A bivariate distribution function of the burst intensities is fitted to the data and is used to determine that the typical ratio of X-ray intensity to type II intensity is about 10 and that the ratio of the number of X-ray producing-electrons to type III-producing electrons is about 1000. Three models which have been proposed to explain the relation between the accelerated hard X-ray and type III-producing electrons are examined in the context of these observations. 17 refs.

  16. A study of the mechanism and kinetics of cyclooctene epoxidation catalyzed by iron(III) tetrakispentafluorophenyl porphyrin.

    PubMed

    Stephenson, Ned A; Bell, Alexis T

    2005-06-22

    A study has been conducted of the mechanism and kinetics of cyclooctene epoxidation by hydrogen peroxide catalyzed by iron(III) tetrakispentafluorophenyl [F(20)TPPFe(III)] porphyrin. The formation of cyclooctene oxide, the only product, was determined by gas chromatography, and the consumption of hydrogen peroxide was determined by (1)H NMR. UV-visible spectroscopy was used to identify the state of the porphyrin as a function of solvent composition and reaction conditions and to follow the kinetics of porphyrin degradation. F(20)TPPFe(III) was found to be inactive in the chloride-ligated form, but became active when the chloride ligand was replaced by a methoxide ligand. The methoxide-ligated form of F(20)TPPFe(III) reacts with hydrogen peroxide to form an iron(III) hydroperoxide species, which then undergoes both heterolytic and homolytic cleavage to form iron(IV) pi-radical cations and iron(IV) oxo species, respectively. The iron(IV) pi-radical cations are responsible for the epoxidation of cyclooctene, whereas the iron(IV) oxo species are responsible for hydrogen peroxide decomposition. The kinetics of cyclooctene epoxidation and hydrogen peroxide decomposition developed from the proposed mechanism describe the experimentally observed kinetics accurately. The rate parameters derived from a fit of the model to the experimental data are consistent with previous estimates of the magnitude of these parameters.

  17. Aluminum potassium sulfate and tannic acid sclerotherapy for Goligher Grades II and III hemorrhoids: Results from a multicenter study

    PubMed Central

    Miyamoto, Hidenori; Hada, Takenori; Ishiyama, Gentaro; Ono, Yoshito; Watanabe, Hideo

    2016-01-01

    AIM: To show that aluminum potassium sulfate and tannic acid (ALTA) sclerotherapy has a high success rate for Grade II and III hemorrhoids. METHODS: This study was based on the clinical data of 604 patients with hemorrhoids who underwent ALTA sclerotherapy between January 2009 and February 2015. The objective of this study was to assess the efficacy of this treatment for Grades II and III hemorrhoids. Preoperative and postoperative symptoms, complications and success rate were all assessed retrospectively. Follow-up consisted of a simple questionnaire, physical examination and an anoscopy. Patients were followed-up at one day, one week, two weeks, one month, one year, two years, three years, four years and five years after the ALTA sclerotherapy. RESULTS: One hundred and sixty-nine patients were diagnosed with Grade II hemorrhoids and 435 patients were diagnosed with Grade III hemorrhoids. The one year, three year and five year cumulative success rates of ALTA sclerotherapy for Grades II and III hemorrhoids were 95.9% and 93.1%; 89.3% and 83.7%; and 89.3% and 78.2%, respectively. No significant differences were observed in the cumulative success rates after ALTA sclerotherapy between Grades II and III hemorrhoids (P = 0.09). There were forty-seven post-operative complications (low grade fever; anal pain; urinary retention; rectal ulcer; and others). No serious or life-threatening complications occurred and all cases improved through conservative treatment. At univariate analysis there were no predictive factors of failure. CONCLUSION: ALTA sclerotherapy has had a high success rate for Grade II and III hemorrhoids during five years of post-operative treatment. However, additional studies are needed to evaluate the efficacy of this ALTA sclerotherapy in the management of hemorrhoidal disease. PMID:27458504

  18. Antithrombin III in patients admitted to intensive care units: a multicenter observational study

    PubMed Central

    Messori, Andrea; Vacca, Franca; Vaiani, Monica; Trippoli, Sabrina

    2002-01-01

    Introduction The administration of antithrombin III (ATIII) is useful in patients with congenital deficiency, but evidence for the other therapeutic indications of this drug is still uncertain. In Italy, the use of ATIII is very common in intensive care units (ICUs). For this reason we undertook an observational study to determine the pattern of use of ATIII in ICUs and to assess the outcome of patients given this treatment. Methods From 20 May to 20 July 2001 all consecutive patients admitted to ICUs in 20 Italian hospitals and treated with ATIII were enrolled. The following information was recorded from each patient: congenital deficiency, indication for use of ATIII, daily dose and duration of ATIII treatment, outcome of hospitalization (alive or dead). The outcome data of our observational study were compared with those reported in previously published randomized controlled trials (RCTs). Results Two hundred and sixteen patients were enrolled in the study. The clinical indications for using ATIII were sepsis (25.9%), disseminated intravascular coagulation (23.1%), and other clinical conditions (46.8%). At the end of the study, 65.3% of the patients were alive, 24.5% died and 10.2% were still in the hospital. Among the patients with sepsis (n = 56), 19 died during the observation period (33.9%; 95% confidence interval 22.1–47.5%). Discussion Our study described the pattern of use of ATIII in Italian hospitals and provided information on the outcome of the subgroup treated with sepsis. A meta-analysis of current data from RCTs, together with our findings, indicates that there is no sound basis for using this drug in ICU patients with sepsis. PMID:12398786

  19. Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions.

    PubMed

    Dobkin, Bruce H

    2009-01-01

    Based on the suboptimal research pathways that finally led to multicenter randomized clinical trials (MRCTs) of treadmill training with partial body weight support and of robotic assistive devices, strategically planned successive stages are proposed for pilot studies of novel rehabilitation interventions. Stage 1, consideration-of-concept studies, drawn from animal experiments, theories, and observations, delineate the experimental intervention in a small convenience sample of participants, so the results must be interpreted with caution. Stage 2, development-of-concept pilots, should optimize the components of the intervention, settle on most appropriate outcome measures, and examine dose-response effects. A well-designed study that reveals no efficacy should be published to counterweight the confirmation bias of positive trials. Stage 3, demonstration-of-concept pilots, can build out from what has been learned to test at least 15 participants in each arm, using random assignment and blinded outcome measures. A control group should receive an active practice intervention aimed at the same primary outcome. A third arm could receive a substantially larger dose of the experimental therapy or a combinational intervention. If only 1 site performed this trial, a different investigative group should aim to reproduce positive outcomes based on the optimal dose of motor training. Stage 3 studies ought to suggest an effect size of 0.4 or higher, so that approximately 50 participants in each arm will be the number required to test for efficacy in a stage 4, proof-of-concept MRCT. By developing a consensus around acceptable and necessary practices for each stage, similar to CONSORT recommendations for the publication of phase III clinical trials, better quality pilot studies may move quickly into better designed and more successful MRCTs of experimental interventions.

  20. Genetics Home Reference: mucolipidosis III alpha/beta

    MedlinePlus

    ... Health Conditions mucolipidosis III alpha/beta mucolipidosis III alpha/beta Enable Javascript to view the expand/collapse ... PDF Open All Close All Description Mucolipidosis III alpha/beta is a slowly progressive disorder that affects ...

  1. Study of Cobalt(III) Corrole as the Neutral Ionophore for Nitrite and Nitrate Detection via Polymeric Membrane Electrodes

    PubMed Central

    Yang, Si; Meyerhoff, Mark E.

    2014-01-01

    Cobalt(III) 5, 10, 15-tris(4-tert-butylphenyl) corrole was synthesized and incorporated into plasticized poly(vinyl chloride) membranes and studied as a neutral carrier ionophore via potentiometry. This cobalt(III) complex has binding affinity to nitrite, and the resulting membrane electrode yields reversible and Nernstian response toward nitrite. Enhanced nitrite selectivity is observed over other anions, including lipophilic anions such as thiocyanate and perchlorate when an appropriate amount of lipophilic cationic sites are added to the membrane phase. Detection limit to nitrite is ca. 5 µM. Using tributylphosphate as the plasticizer with the cobalt(III) corrole species yields electrodes with enhanced nitrate selectivity. PMID:25422577

  2. Molecular structure and biological studies on Cr(III), Mn(II) and Fe(III) complexes of heterocyclic carbohydrazone ligand

    NASA Astrophysics Data System (ADS)

    Abu El-Reash, G. M.; El-Gammal, O. A.; Radwan, A. H.

    2014-03-01

    The chelating behavior of the ligand (H2APC) based on carbohydrazone core modified with pyridine end towards Cr(III), Mn(II) and Fe(III) ions have been examined. The 1H NMR and IR data for H2APC revealed the presence of two stereoisomers syn and anti in both solid state and in solution in addition to the tautomeric versatility based on the flexible nature of the hydrazone linkage leading to varied coordination modes. The spectroscopic data confirmed that the ligand behaves as a monobasic tridentate in Cr(III) and Fe(III) complexes and as neutral tetradentate in Mn(II) complex. The electronic spectra as well as the magnetic measurements confirmed the octahedral geometry for all complexes. The bond length and angles were evaluated by DFT method using material studio program for all complexes. The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. The antioxidant (DDPH and ABTS methods), anti-hemolytic and cytotoxic activities of the compounds have been screened. Cr(III) complex and H2APC showed the highest antioxidant activity using ABTS and DPPH methods. With respect to in vitro Ehrlich ascites assay, H2APC exhibited the potent activity followed by Fe(III) and Cr(III)complexes.

  3. Synthesis, spectroscopic, thermal and anticancer studies of metal-antibiotic chelations: Ca(II), Fe(III), Pd(II) and Au(III) chloramphenicol complexes

    NASA Astrophysics Data System (ADS)

    Al-Khodir, Fatima A. I.; Refat, Moamen S.

    2016-09-01

    Four Ca(II), Fe(III), Pd(II) and Au(III) complexes of chloramphenicol drug have been synthesized and well characterized using elemental analyses, (infrared, electronic, and 1H-NMR) spectra, magnetic susceptibility measurement, and thermal analyses. Infrared spectral data show that the chloramphenicol drug coordinated to Ca(II), Pd(II) and Au(III) metal ions through two hydroxyl groups with 1:1 or 1:2 M ratios, but Fe(III) ions chelated towards chloramphenicol drug via the oxygen and nitrogen atoms of amide group with 1:2 ratio based on presence of keto↔enol form. The X-ray powder diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscopy (TEM) techniques were used to identify the nano-size particles of both iron(III) and gold(III) chloramphenicol complexes. The antimicrobial assessments of the chloramphenicol complexes were scanned and collected the results against of some kind of bacteria and fungi. The cytotoxic activity of the gold(III) complex was tested against the human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG-2) tumor cell lines.

  4. Serum 25-Hydroxyvitamin D and Cancer Mortality in the NHANES III Study (1988–2006)

    PubMed Central

    Freedman, D. Michal; Looker, Anne C.; Abnet, Christian C.; Linet, Martha S.; Graubard, Barry I.

    2010-01-01

    Vitamin D has been hypothesized to protect against cancer. We followed 16,819 participants in NHANES III from 1988 through 2006, expanding upon an earlier NHANES III study (1988–2000). Using Cox proportional hazard regression models, we examined risk related to baseline serum 25-hydroxyvitamin D (25(OH)D) for total cancer mortality, in both sexes, and by racial/ethnic groups, as well as for site-specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season (“summer/higher latitude” and “winter/lower latitude”). We identified 884 cancer deaths during 225,212 person-years. Overall cancer mortality risks were unrelated to baseline 25(OH)D status in both season/latitude groups, and in non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans. In men, risks were elevated at higher levels (e.g., for ≥100 nmol/L, RR=1.85 (95% CI=1.02–3.35) compared to <37.5 nmol/L). Athough risks were unrelated to 25(OH)D in all women combined, risks significantly decreased with increasing 25(OH)D in the summer/higher latitude group (for ≥100 nmol/L, RR= 0.52 (95% CI=0.25–1.15) compared to <37.5 nmol/L, P-trend=0.03, based on continuous values). We also observed a suggestion of an inverse association with colorectal cancer mortality(P-trend=0.09) and a positive association with lung cancer mortality among males (P-trend=0.03). Our results do not support a the hypothesis that 25(OH)D is associated with reduced cancer mortality. Although cancer mortality in females was inversely associated with 25(OH)D in the summer/higher latitude group, cancer mortality at some sites was increased among men with higher 25(OH)D. These findings argue for caution before increasing 25(OH)D levels to prevent cancer. PMID:20847342

  5. [Hemodynamic study of intravenous milrinone in 26 patients with NYHA class III or IV cardiac failure].

    PubMed

    Boesch, C; Dubois-Rande, J L; Pochmalicki, G; Lellouche, D; Teiger, E; Saal, J P; Cachin, J C; Mallo, C; Castaigne, A; Jan, F

    1992-11-01

    The hemodynamic effects of milrinone (WIN 47203) were studied in 26 NYHA Class III or IV patients. The compound was administered intravenously using a protocol including an initial push dose of 50 micrograms/kg in 10 min, followed by a 24 hour infusion at the dose of 0.5 microgram/kg/min. Maximal response was obtained after 15 min and persisted during the infusion: cardiac index increased from 2.08 +/- 0.36 l/min/m2 to 3.09 +/- 0.68 l/min/m2, while capillary pressure fell from 25 mmHg to 16-17 mmHg. These variations were significant (p = 0.01). Heart rate was stable. Mean peripheral blood pressure fell modestly (6%). Systemic vascular resistance fell by 30% and pulmonary vascular resistance by 20%. All these results confirmed the beneficial effect of this inotropic agent administered intravenously. The increase in ventricular premature contractions noted by many justifies the careful surveillance of these patients by monitoring.

  6. Ab initio study of Al(III) adsorption on stepped {100} surfaces of KDP crystals

    SciTech Connect

    Salter, E A; Wierzbicki, A; Land, T A

    2004-04-01

    Crystals of potassium dihydrogen phosphate (KH{sub 2}PO{sub 4}, KDP) are grown in large scale for use as nonlinear material in laser components. Traces of trivalent metal impurities are often added to the supernatant to achieve habit control during crystal growth, selectively inhibiting the growth of the {l_brace}100{r_brace} face. Model systems representing AlPO{sub 4}-doped KDP {l_brace}100{r_brace} stepped surfaces are prepared and studied using ab initio quantum methods. Results of Hartree-Fock partial optimizations are presented, including estimated energies of ion pair binding to the steps. We find that the PO{sub 4}{sup 3-} ion takes a position not unlike that of a standard phosphate in the crystal lattice, while the aluminum atom is displaced far from a K{sup +} ion position to establish coordinations with the PO{sub 4}{sup 3-} ion and to bind with another lattice-bound phosphate. Our optimized structures suggest that it is the formation of a fourth coordination of Al(III) to a third phosphate ion from solution, or perhaps from a nearby position in the lattice, that disrupts further deposition, pinning the steps.

  7. Formation of anodic layers on InAs (111)III. Study of the chemical composition

    SciTech Connect

    Valisheva, N. A. Tereshchenko, O. E.; Prosvirin, I. P.; Kalinkin, A. V.; Goljashov, V. A.; Levtzova, T. A.; Bukhtiyarov, V. I.

    2012-04-15

    The chemical composition of {approx}20-nm-thick anodic layers grown on InAs (111)III in alkaline and acid electrolytes containing or not containing NH{sub 4}F is studied by X-ray photoelectron spectroscopy. It is shown that the composition of fluorinated layers is controlled by the relation between the concentrations of fluorine and hydroxide ions in the electrolyte and by diffusion processes in the growing layer. Fluorine accumulates at the (anodic layer)/InAs interface. Oxidation of InAs in an acid electrolyte with a low oxygen content and a high NH{sub 4}F content brings about the formation of anodic layers with a high content of fluorine and elemental arsenic and the formation of an oxygen-free InF{sub x}/InAs interface. Fluorinated layers grown in an alkaline electrolyte with a high content of O{sup 2-} and/or OH{sup -} groups contain approximately three times less fluorine and consist of indium and arsenic oxyfluorides. No distinction between the compositions of the layers grown in both types of fluorine-free electrolytes is established.

  8. Syntheses, Characterization, Thermal, and Antimicrobial Studies of Lanthanum(III) Tolyl/Benzyldithiocarbonates

    PubMed Central

    Andotra, Savit; Kalgotra, Nidhi; Pandey, Sushil K.

    2014-01-01

    Lanthanum(III) tris(O-tolyl/benzyldithiocarbonates), [La(ROCS2)] (R = o-, m-, p-CH3C6H4 and C6H5CH2), were isolated as yellow solid by the reaction of LaCl3·7H2O with sodium salt of tolyl/benzyldithiocarbonates, ROCS2Na (R = o-, m-, p-CH3C6H4 and C6H5CH2), in methanol under anhydrous conditions in 1 : 3 molar ratio. These complexes have formed adducts with nitrogen and phosphorus donor molecules by straightforward reaction of these complexes with donor ligands, which have the composition of the type [La(ROCS2)3·nL] (where n = 2, L = NC5H5 or P(C6H5)3 and n = 1, L = N2C12H8 or N2C10H8). Elemental analyses, mass, IR, TGA, and heteronuclear NMR (1H, 13C and 31P) spectroscopic studies indicated bidentate mode of bonding by dithiocarbonate ligands leading to hexacoordinated and octacoordinated geometry around the lanthanum atom. Antimicrobial (antifungal and antibacterial) activity of the free ligands and some of the complexes have also been investigated which exhibited significantly more activity for the complexes than the free ligands. PMID:24817836

  9. Comparative studies on group III σ-hole and π-hole interactions.

    PubMed

    Gao, Lei; Zeng, Yanli; Zhang, Xueying; Meng, Lingpeng

    2016-05-30

    The σ-hole of M2 H6 (M = Al, Ga, In) and π-hole of MH3 (M = Al, Ga, In) were discovered and analyzed, the bimolecular complexes M2 H6 ···NH3 and MH3 ···N2 P2 F4 (M = Al, Ga, In) were constructed to carry out comparative studies on the group III σ-hole interactions and π-hole interactions. The two types of interactions are all partial-covalent interactions; the π-hole interactions are stronger than σ-hole interactions. The electrostatic energy is the largest contribution for forming the σ-hole and π-hole interaction, the polarization energy is also an important factor to form the M···N interaction. The electrostatic energy contributions to the interaction energy of the σ-hole interactions are somewhat greater than those of the π-hole interactions. However, the polarization contributions for the π-hole interactions are somewhat greater than those for the σ-hole interactions.

  10. Triga Mark III Reactor Operating Power and Neutron Flux Study by Nuclear Track Methodology

    NASA Astrophysics Data System (ADS)

    Espinosa, G.; Golzarri, J. I.; Raya-Arredondo, R.; Cruz-Galindo, S.; Sajo-Bohus, L.

    The operating power of a TRIGA Mark III reactor was studied using Nuclear Track Methodology (NTM). The facility has a Highly Enriched Uranium core that provides a neutron flux of around 2 x 1012 n cm-2 s-1 in the TO-2 irradiation channel. The detectors consisted of a Landauer® CR-39 (allyl diglycol polycarbonate) chip covered with a 3 mm Plexiglas® converter. After irradiation, the detectors were chemically etched in a 6.25M-KOH solution at 60±1 °C for 6 h. Track density was determined by a custom-made Digital Image Analysis System. The results show a direct proportionality between reactor power and average nuclear track density for powers in the range 0.1-7 kW. Data reproducibility and relatively low uncertainty (±3%) were achieved. NTM is a simple, fast and reliable technique that can serve as a complementary procedure to measure reactor operating power. It offers the possibility of calibrating the neutron flux density in any low power reactor.

  11. Dolomitization as control on reservoir quality - case study: Block III, Lake Maracaibo, Venezuela

    SciTech Connect

    Marquez, X.

    1989-03-01

    Paleocene carbonate sequences in Block III, Lake Maracaibo, have always been neglected, even though similar sequences such as those reported in the Smackover Formation, Gulf of Mexico coastal plain, USA, have shown great hydrocarbon potential. Core study in well VLC-950 shows that the Paleocene carbonate sequence consists of four oolitic facies: skeletal-oolitic rudstones (C1), oolitic packstones/grainstones(C2), oolitic grainstones (C3), and sandy oolitic grainstones (C4), all deposited in a prospective shallowing-upward carbonate sand sequence. Diagenetic processes such as micritization, calcite cementation, solution, dolomitization, and compaction have modified the original textures of these facies. It seems that the dolomitization has been the most important in controlling effective porosity. Dolomitization has occurred in the whole sequence. In C1, it is represented by isolated, fine, euhedral crystals. In C2, dolomitization has selectively replaced the oolites with a mosaic of coarse, anhedral crystals. In C3, dolomitization has selectively replaced the calcite cement and to a much lesser extent the oolites. Oolites not dolomitized have been selectively leached, resulting in well-developed oomoldic porosity that forms the reservoirs. In C4, dolomitization is minor, and it is represented by isolated, very fine crystals. Petrophysical analysis revealed that in C3 the porosity value is 19%, permeability is 1.21 md, and oil saturation is 80%; in C1, C2, and C4, porosity averages 4.3%, permeability is 0.06 md, and oil saturation is negligible.

  12. Formulation and immunogenicity studies of type III secretion system needle antigens as vaccine candidates.

    PubMed

    Barrett, Brooke S; Markham, Aaron P; Esfandiary, Reza; Picking, Wendy L; Picking, William D; Joshi, Sangeeta B; Middaugh, C Russell

    2010-11-01

    Bacterial infections caused by Shigella flexneri, Salmonella typhimurium, and Burkholderia pseudomallei are currently difficult to prevent due to the lack of a licensed vaccine. Here we present formulation and immunogenicity studies for the three type III secretion system (TTSS) needle proteins MxiH(Δ5), PrgI(Δ5), and BsaL(Δ5) (each truncated by five residues at its C terminus) as potential candidates for vaccine development. These antigens are found to be thermally stabilized by the presence of carbohydrates and polyols. Additionally, all adsorb readily to aluminum hydroxide apparently through a combination of hydrogen bonds and/or Van der Waals forces. The interaction of these proteins with the aluminum-based adjuvant changes with time resulting in varying degrees of irreversible binding. Peptide maps of desorbed protein, however, suggest that chemical changes are not responsible for this irreversible association. The ability of MxiH(Δ5) and PrgI(Δ5) to elicit strong humoral immune responses was tested in a murine model. When administered intramuscularly as monomers, the needle components exhibited dose dependent immunogenic behavior. The polymerized version of MxiH was exceptionally immunogenic even at low doses. The responses of both monomeric and polymerized forms were boosted by adsorption to an aluminum salt adjuvant.

  13. Formulation and Immunogenicity studies of Type III Secretion System needle antigens as Vaccine Candidates

    PubMed Central

    Barrett, Brooke S.; Markham, Aaron P.; Esfandiary, Reza; Picking, Wendy L.; Picking, William D.; Joshi, Sangeeta B.; Middaugh, C. Russell

    2013-01-01

    Bacterial infections caused by Shigella flexneri, Salmonella typhimurium and Burkholderia pseudomallei are currently difficult to prevent due to the lack of a licensed vaccine. Here we present formulation and immunogenicity studies for the three type III secretion system (TTSS) needle proteins MxiHΔ5, PrgIΔ5 and BsaLΔ5 (each truncated by five residues at its C terminus) as potential candidates for vaccine development. These antigens are found to be thermally stabilized by the presence of carbohydrates and polyols. Additionally, all adsorb readily to aluminum hydroxide apparently through a combination of hydrogen bonds and/or Van der Waals forces. The interaction of these proteins with the aluminum-based adjuvant changes with time to resulting in varying degrees of irreversible binding. Peptide maps of desorbed protein, however, suggest that chemical changes are not responsible for this irreversible association. The ability of MxiHΔ5 and PrgIΔ5 to elicit strong humoral immune responses was tested in a murine model. When administered intramuscularly as monomers, the needle components exhibited dose dependent immunogenic behavior. The polymerized version of MxiH was exceptionally immunogenic even at low doses. The responses of both monomeric and polymerized forms were boosted by adsorption to an aluminum salt adjuvant. PMID:20845448

  14. Modelling studies in aqueous solution of lanthanide (III) chelates designed for nuclear magnetic resonance biomedical applications

    NASA Astrophysics Data System (ADS)

    Henriques, E. S.; Geraldes, C. F. G. C.; Ramos, M. J.

    Molecular dynamics simulations and complementary modelling studies have been carried out for the [Gd(DOTA)·(H2O)]- and [Tm(DOTP)]5- chelates in aqueous media, to provide a better understanding of several structural and dynamical properties of these versatile nuclear magnetic resonance (NMR) probes, including coordination shells and corresponding water exchange mechanisms, and interactions of these complexes with alkali metal ions. This knowledge is of key importance in the areas of 1H relaxation and shift reagents for NMR applications in medical diagnosis. A new refinement of our own previously developed set of parameters for these Ln(III) chelates has been used, and is reported here. Calculations of water mean residence times suggest a reassessment of the characterization of the chelates' second coordination shell, one where the simple spherical distribution model is discarded in favour of a more detailed approach. Na+ probe interaction maps are in good agreement with the available site location predictions derived from 23Na NMR shifts.

  15. Americium(iii) and europium(iii) complex formation with lactate at elevated temperatures studied by spectroscopy and quantum chemical calculations.

    PubMed

    Barkleit, Astrid; Kretzschmar, Jerome; Tsushima, Satoru; Acker, Margret

    2014-08-01

    Thermodynamic parameters for the complex formation of Am(iii) and Eu(iii) with lactate were determined with UV-vis and time-resolved laser-induced fluorescence spectroscopy (TRLFS) in a temperature range between 25 and 70 °C. The reaction enthalpy decreased with increasing ionic strength. ATR FT-IR and NMR spectroscopy in combination with density functional theory (DFT) calculations revealed structural details of the Eu(iii) lactate 1 : 1 complex: a chelating coordination mode of the lactate with a monodentate binding carboxylate group and the hydroxyl group being deprotonated.

  16. Study for Teaching Behavioral Sciences in Schools of Medicine, Volume III: Behavioral Science Perspectives in Medical Education.

    ERIC Educational Resources Information Center

    American Sociological Association, Washington, DC. Medical Sociology Council.

    Volume III of a study of teaching behavioral sciences in medical school presents perspectives on medical behavioral science from the viewpoints of the several behavioral disciplines (anthropology, psychology, sociology, political science, economics, behavioral biology and medical education). In addition, there is a discussion of translating…

  17. Revision of Primary I-III Science Curriculum in Somalia. African Studies in Curriculum Development & Evaluation No. 83.

    ERIC Educational Resources Information Center

    Abdi, Ahmed Ali

    This study was designed to evaluate: (1) the content of the primary I-III science curriculum in Somalia; (2) the instructional materials that back up the content and methodologies; and (3) the professional competence of the teachers in charge of teaching this subject. Data were collected by means of a questionnaire, observations, and unstructured…

  18. Study of the Need for Educational Manpower for Handicapped Children and Youth: Part A - Phase III. Final Report.

    ERIC Educational Resources Information Center

    Mintz, Raymond D.; And Others

    Phase III of the Study of the Need for Educational Manpower for Handicapped Children and Youth, in demonstrating the feasibility of the Manpower Requirements Projection Model (MRPM), gathered data in the states necessary for implementation of the model. The MRPM was developed to enable state or local administrators of special education to estimate…

  19. Probing the Natural World, Level III, Teacher's Edition: Why You're You. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). The chapters include basic information about heredity, activities, and optional "excursions." The answers to all activities are included. An introduction describes the work of Gregor Mendel and his…

  20. Insights into the coordination mode of quercetin with the Al(III) ion from a combined experimental and theoretical study.

    PubMed

    Furia, Emilia; Marino, Tiziana; Russo, Nino

    2014-05-21

    Combining potentiometric, spectroscopic and theoretical DFT computations we have studied the formation of the Al(iii)-quercetin complex in ethanol solution. The possible complexation sites have been considered on the basis of all the experimental and theoretical tools used. Results supported proposing a 1 : 1 neutral complex and the possibility to have different isomers in solution.

  1. Studies of Open Clusters using 50BiN

    NASA Astrophysics Data System (ADS)

    Deng, Licai; Xin, Yu; Zhang, Xiaobin; Wang, Kun; Luo, Changqing

    2015-08-01

    50BiN (50cm Binocular Network) is a sub-program of SONG, funded by Chinese participating universities. The Science goals is to do simulteneous two-color widep-field photometry of Galactic open clusters in time-domain, and to study the fundamental properties of the clusters and to search variable objects in a systematic manner. The proto-type node, located in West-China, is now in operation. The science plan of the program and some preliminary results will be presented.

  2. Rodent-repellent studies. III. Advanced studies in the evaluation of chemical repellents

    USGS Publications Warehouse

    Bellack, E.; DeWitt, J.B.

    1949-01-01

    In order to bridge the gap between preliminary screening of chemicals for potential rodent repellency and the application ofthese compounds to paper cartons, more advanced studies in the evaluation ofpromising materials have been carried out. These studies have resulted in: (1) a modification of the food acceptance technique which eliminates doubtful compounds and also provides a closer analogy to the ultimate goal, and (2) a method for rapidly testing chemicals incorporated in paper. When the results of these latter tests are expressed as a function of time, it can be shown that a distinct correlation exists between the deterrency exhibited by treated paper and the repellency of treated food.

  3. A Longitudinal Study of Man: A Course of Study. Volume III: Interviews.

    ERIC Educational Resources Information Center

    Cort, H. Russell, Jr.; Peskowitz, Nancy

    This document, the third volume of the summative evaluation of "Man: A Course of Study" (MACOS), describes and evaluates the interviews which were conducted with MACOS students and teachers during the 1974-75 school year. Project staff members conducted and tape recorded 20-minute interviews with teachers and small groups of students three times…

  4. Case Studies and Promising Approaches. Vocational Education Equity Study. Final Report: Volume III.

    ERIC Educational Resources Information Center

    Wheeler, Jeanette D.; And Others

    Information on programs and activities which have been developed to reduce sex inequities in vocational education is provided. The document is organized into two sections: section 1 contains case studies of twelve programs selected from a nationwide search, and section 2 contains brief descriptions of twelve promising approaches to reducing sex…

  5. Comparative Analysis Study of Open Source GIS in Malaysia

    NASA Astrophysics Data System (ADS)

    Rasid, Muhammad Zamir Abdul; Kamis, Naddia; Khuizham Abd Halim, Mohd

    2014-06-01

    Open source origin might appear like a major prospective change which is qualified to deliver in various industries and also competing means in developing countries. The leading purpose of this research study is to basically discover the degree of adopting Open Source Software (OSS) that is connected with Geographic Information System (GIS) application within Malaysia. It was derived based on inadequate awareness with regards to the origin ideas or even on account of techie deficiencies in the open origin instruments. This particular research has been carried out based on two significant stages; the first stage involved a survey questionnaire: to evaluate the awareness and acceptance level based on the comparison feedback regarding OSS and commercial GIS. This particular survey was conducted among three groups of candidates: government servant, university students and lecturers, as well as individual. The approaches of measuring awareness in this research were based on a comprehending signal plus a notion signal for each survey questions. These kinds of signs had been designed throughout the analysis in order to supply a measurable and also a descriptive signal to produce the final result. The second stage involved an interview session with a major organization that carries out available origin internet GIS; the Federal Department of Town and Country Planning Peninsular Malaysia (JPBD). The impact of this preliminary study was to understand the particular viewpoint of different groups of people on the available origin, and also their insufficient awareness with regards to origin ideas as well as likelihood may be significant root of adopting level connected with available origin options.

  6. A modeling study of notch noise responses of type III units in the gerbil dorsal cochlear nucleus.

    PubMed

    Zheng, Xiaohan; Voigt, Herbert F

    2006-12-01

    A computational model of the neural circuitry of the gerbil dorsal cochlear nucleus (DCN), based on the MacGregor's neuromime model, was used to simulate type III unit (P-cell) responses to notch noise stimuli. The DCN patch model is based on a previous computational model of the cat DCN [Hancock, K. E., and H. F. Voigt. Ann. Biomed. Eng. 27:73-87, 1999]. According to the experimental study of Parsons et al. [Ann. Biomed. Eng. 29:887-896, 2001], the responses of gerbil DCN type III units to notch noise stimuli are similar to those of cat DCN type IV units, which are thought to be spectral notch detectors. This suggests that type III units in the gerbil DCN may serve as spectral notch detectors. In this modeling study, a simplified notch noise response plot--spike discharge rate vs. notch cutoff frequency plot--was used to compare model responses to the experimental results. Parameter estimation and sensitivity analysis of three connection parameters within the DCN patch have been studied and shows the model is robust, providing reasonable fits to the experimental data from 14 of 15 type III units examined.

  7. HLA-D gene studies in relation to immune responsiveness to a grass allergen Lol p III.

    PubMed

    Ansari, A A; Shinomiya, N; Zwollo, P; Marsh, D G

    1991-01-01

    The grass pollen allergen Lol p III (Mr 11,000) is a well-characterized antigen that has been found useful in immunogenetic studies of human immune responsiveness. Since immune responsiveness to this allergen is associated with HLA-DR3, we investigated whether there was any sequence in the HLA-D region that would render a person "susceptible" [antibody (Ab)-positive] to the allergen. By sequence-specific oligonucleotide (SSO) slot-blot and sequence analyses of polymerase chain reaction (PCR)-amplified genomic DNA from Lol p III responder and nonresponder subjects, Ab responsiveness was found to be strongly associated with the sequence Glu-Tyr-Ser-Thr-Ser (EYSTS), present in the first polymorphic regions of DR beta I polypeptide chains of DR3, DR11 (split of DR5), and DRw6. Of the 41 grass-allergic subjects investigated, 19 had the EYSTS sequence, of whom 18 (95%) were Lol p III immunoglobulin G (IgG) Ab responders; among the 22 EYSTS- subjects, ten were Lol p III responders (P = 0.001, relative risk = 21.6). No such association was found with any polymorphic sequences in other DR beta chains, or in DQ alpha I and DQ beta I chains. These findings suggest that the EYSTS sequence is important in the presentation of an epitope of Lol p III; other sequence(s) may be involved in the presentation of other epitope(s). To our knowledge, this is the first demonstration of a strong association between a specific HLA sequence and immune responsiveness to a well-defined antigen. The paper shows that presence of the EYSTS sequence classifies subjects as Lol p III responders in 18/19 cases.

  8. Synthesis, spectroscopic, thermal and antifungal studies on lanthanum(III) and praseodymium(III) derivatives of 1,1-diacetylferrocenyl hydrazones

    NASA Astrophysics Data System (ADS)

    Sengupta, S. K.; Pandey, O. P.; Rai, Anita; Sinha, A.

    2006-09-01

    A series of new coordination complexes of La(III) and Pr(III) with hydrazones, derived from 1,1-diacetylferrocene and different aromatic acid hydrazides have been synthesized and characterized by elemental analyses, electrical conductance, magnetic moment, IR, 1H NMR, UV-vis spectra and molar conductance. The thermal behaviour of the complexes under non-isothermal condition was investigated by TG and DTG techniques. The antifungal activity of hydrazones and their corresponding complexes were also investigated.

  9. Synthesis, spectroscopic, thermal and antifungal studies on lanthanum(III) and praseodymium(III) derivatives of 1,1-diacetylferrocenyl hydrazones.

    PubMed

    Sengupta, S K; Pandey, O P; Rai, Anita; Sinha, A

    2006-09-01

    A series of new coordination complexes of La(III) and Pr(III) with hydrazones, derived from 1,1-diacetylferrocene and different aromatic acid hydrazides have been synthesized and characterized by elemental analyses, electrical conductance, magnetic moment, IR, (1)H NMR, UV-vis spectra and molar conductance. The thermal behaviour of the complexes under non-isothermal condition was investigated by TG and DTG techniques. The antifungal activity of hydrazones and their corresponding complexes were also investigated.

  10. Course Evaluation in Open and Distance Learning: A Case Study from Indira Gandhi National Open University

    ERIC Educational Resources Information Center

    Gaba, Ashok K.; Dash, Nirod K.

    2004-01-01

    The success of any open and distance learning course depends on how well it is designed, executed, and evaluated. Evaluation of a course not only demonstrates its strengths, but also points out any inherent shortcomings in the course. This is why course evaluation constitutes an important function in an open and distance learning system. The…

  11. Opening Education: Policies and Practices from Open and Distance Education. Routledge Studies in Distance Education Series.

    ERIC Educational Resources Information Center

    Evans, Terry, Ed.; Nation, Daryl, Ed.

    The overall theme of this book is the relationships between government and organizational policies and the work of practitioners in open and distance learning. The book explores a selection of international examples, many of which concern the use of new technologies for opening education. The contributors, many of whom are recognized experts,…

  12. Perinatal ischemic stroke: a five-year retrospective study in a level-III maternity

    PubMed Central

    Machado, Virgínia; Pimentel, Sónia; Pinto, Filomena; Nona, José

    2015-01-01

    Objective To study the incidence, clinical presentation, risk factors, imaging diagnosis, and clinical outcome of perinatal stroke. Methods Data was retrospectively collected from full-term newborns admitted to the neonatal unit of a level III maternity in Lisbon with cerebral stroke, from January 2007 to December 2011. Results There were 11 cases of stroke: nine were arterial ischemic stroke and two were cerebral venous sinus thrombosis. We estimated an incidence of arterial ischemic stroke of 1.6/5,000 births and of cerebral venous sinus thrombosis of 7.2/100,000 births. There were two cases of recurrent stroke. Eight patients presented with symptoms while the remaining three were asymptomatic and incidentally diagnosed. The most frequently registered symptoms (8/11) were seizures; in that, generalized clonic (3/8) and focal clonic (5/8). Strokes were more commonly left-sided (9/11), and the most affected artery was the left middle cerebral artery (8/11). Transfontanelle ultrasound was positive in most of the patients (10/11), and stroke was confirmed by cerebral magnetic resonance in all patients. Electroencephalographic recordings were carried out in five patients and were abnormal in three (focal abnormalities n=2, burst-suppression pattern n=1). Eight patients had previously identified risk factors for neonatal stroke which included obstetric and neonatal causes. Ten patients were followed up at outpatients setting; four patients developed motor deficits and one presented with epilepsy. Conclusions Although a modest and heterogeneous sample, this study emphasizes the need for a high level of suspicion when it comes to neonatal stroke, primarily in the presence of risk factors. The prevalence of neurological sequelae in our series supports the need of long-term follow-up and early intervention strategies. PMID:25993071

  13. Ruthenium(III) catalyzed oxidation of sugar alcohols by dichloroisocyanuric acid—A kinetic study

    NASA Astrophysics Data System (ADS)

    Lakshman Kumar, Y.; Venkata Nadh, R.; Radhakrishnamurti, P. S.

    2016-02-01

    Kinetics of ruthenium(III) catalyzed oxidation of biologically important sugar alcohols (myo-inositol, D-sorbitol, and D-mannitol) by dichloroisocyanuric acid was carried out in aqueous acetic acid—perchloric medium. The reactions were found to be first order in case of oxidant and ruthenium(III). Zero order was observed with the concentrations of sorbitol and mannitol whereas, a positive fractional order was found in the case of inositol concentration. An inverse fractional order was observed with perchloric acid in oxidation of three substrates. Arrhenius parameters were calculated and a plausible mechanism was proposed.

  14. A Case Study of Scholars' Open and Sharing Practices

    ERIC Educational Resources Information Center

    Veletsianos, George

    2015-01-01

    Although the open scholarship movement has successfully captured the attention and interest of higher education stakeholders, researchers currently lack an understanding of the degree to which open scholarship is enacted in institutions that lack institutional support for openness. I help fill this gap in the literature by presenting a descriptive…

  15. Geothermal Exploration Case Studies on OpenEI (Presentation)

    SciTech Connect

    Young, K.; Bennett, M.; Atkins, D.

    2014-03-01

    The U.S. Geological Survey (USGS) resource assessment (Williams et al., 2008) outlined a mean 30 GWe of undiscovered hydrothermal resource in the western United States. One goal of the U.S. Department of Energy's (DOE) Geothermal Technology Office (GTO) is to accelerate the development of this undiscovered resource. DOE has focused efforts on helping industry identify hidden geothermal resources to increase geothermal capacity in the near term. Increased exploration activity will produce more prospects, more discoveries, and more readily developable resources. Detailed exploration case studies akin to those found in oil and gas (e.g. Beaumont and Foster, 1990-1992) will give developers central location for information gives models for identifying new geothermal areas, and guide efficient exploration and development of these areas. To support this effort, the National Renewable Energy Laboratory (NREL) has been working with GTO to develop a template for geothermal case studies on the Geothermal Gateway on OpenEI. In 2012, the template was developed and tested with two case studies: Raft River Geothermal Area (http://en.openei.org/wiki/Raft_River_Geothermal_Area) and Coso Geothermal Area (http://en.openei.org/wiki/Coso_Geothermal_Area). In 2013, ten additional case studies were completed, and Semantic MediaWiki features were developed to allow for more data and the direct citations of these data. These case studies are now in the process of external peer review. In 2014, NREL is working with universities and industry partners to populate additional case studies on OpenEI. The goal is to provide a large enough data set to start conducting analyses of exploration programs to identify correlations between successful exploration plans for areas with similar geologic occurrence models.

  16. Theoretical and experimental studies on binding mode of 3,5-pyrazoledicarboxylic acid in its new La(III) complex

    NASA Astrophysics Data System (ADS)

    Peica, Niculina; Kostova, Irena; Kiefer, Wolfgang

    2006-06-01

    A new La(III) complex with 3,5-pyrazoledicarboxylic acid (HPy) was synthesized and characterized with elemental analysis, IR, and Raman spectroscopies. Significant differences in the IR and Raman spectra of the complex were observed as compared to the spectra of the ligand. The metal-ligand binding mode was studied on the basis of theoretical and experimental data. B3PW91 and B3LYP methods with 6-311++G ∗∗ and LANL2DZ basis sets were successfully applied to study the molecular and vibrational structures as well as the conformational behavior of the neutral ligand and its new La(III) complex. The theoretical calculations of HPy suggested bidentate binding mode through the carboxylic oxygens. Detailed vibrational analysis of HPy and La(III)-Py systems based on both the calculated and experimental spectra confirmed the suggested metal-ligand binding mode. The density functional theory (DFT) calculated geometries, harmonic vibrational wavenumbers including IR and Raman scattering activities for the ligand and its La(III) complex were in good agreement with the experimental data, a complete vibrational assignment being proposed.

  17. Spectroscopic studies on interaction of BSA and Eu(III) complexes with H5ph-dtpa and H5dtpa ligands.

    PubMed

    Kong, Deyong; Qin, Cui; Fan, Ping; Li, Bing; Wang, Jun

    2015-04-01

    An novel aromatic aminopolycarboxylic acid ligand, N-(2-N,N-Dicarboxymethylaminophenyl) ethylenediamine-N,N',N'-triacetic acid (H5ph-dtpa), was synthesized by improving experimental method and its corresponding Eu(III) complex, Na2[EuIII(ph-dtpa)(H2O)]·6H2O, was successfully prepared through heat-refluxing method. As a comparison, the Eu(III) complex with diethylenetriamine-N,N,N',N',N″-pentaacetic acid (H5dtpa) ligand, Na2[Eu(III)(dtpa)(H2O)]·6H2O, was also prepared by the same method. And then, the interaction between prepared Eu(III) complexes ([EuIII(dtpa)(H2O)]2- and [EuIII(ph-dtpa)(H2O)]2-) and bovine serum albumin (BSA) in aqueous solution were studied by the combination of ultraviolet-visible (UV-vis), fluorescence and circular dichroism (CD) spectroscopies. In addition, the binding sites of Eu(III) complexes ([EuIII(dtpa)(H2O)]2- and [EuIII(ph-dtpa)(H2O)]2-) to BSA molecules were also estimated by synchronous fluorescence. Moreover, the theoretical and experimental results show that the Van der Waals, hydrogen bond and π-π stacking interactions are the mainly impulse to the reaction. The binding distances (r) between Eu(III) complexes ([EuIII(dtpa)(H2O)]2- and [EuIII(ph-dtpa)(H2O)]2-) and BSA were obtained according to Förster's non-radiative energy transfer theory. Also, the determined UV-vis absorption spectroscopy, synchronous fluorescence and circular dichroism (CD) spectra showed that the conformation of BSA could be changed in the presence of Eu(III) complexes. The obtained results can help understand the action mode between rare earth metal complexes of aminopolycarboxylic acid ligands with BSA and they are also expected to provide important information of designs of new inspired drugs.

  18. Redox behavior of Ce(IV)/Ce(III) in the presence of nitrilotriacetic acid: A surrogate study for An(I\\T)/AD(III) redox behavior

    SciTech Connect

    Suzuki, Y.; Francis, A.; Nankawa, T.; Ohnuki, T.

    2010-07-01

    Using cyclic voltammetry, we investigated the redox behavior of Ce(IV)/Ce(III), which is a surrogate for An(IV)/An(III) (An=actinides), in a solution of nitrilotriacetic acid (NTA) at 25 C. The cyclic voltammogram of Ce in a 0.1 M NTA solution at pH 6 showed a reversible one-electron redox reaction for Ce(IV)/Ce(III) at 0.51 V vs. Ag/AgCl. This redox potential was much lower than that obtained in 1 M nitric acid, indicating that Ce(IV) was preferentially stabilized by complexation with NTA. The redox potential in the NTA solution was independent of the Ce concentration from 2 to 20 mM, NTA concentration from 5 to 200 mM and pH between 3 and 7. These results indicated that no polymerization and no additional coordination of NTA and OH{sup -} to the Ce(III)-NTA complex took place during the redox reaction. As the speciation calculation of Ce(III) in the NTA solution showed that the predominant species was Ce{sup III}(nta){sub 2}{sup 3-} (H{sub 3}nta = NTA), the redox reaction of the Ce-NTA complex was expressed by the following: Ce{sup IV}(nta){sub 2}{sup 2-} +e{sup -} Ce{sup III}(nta){sub 2}{sup 3-}. The logarithm of the stability constant of Ce{sup IV}(nta){sub 2}{sup 2-} was calculated to be 38.6 {+-} 0.8 for I = 0 from the redox potential shift of Ce(IV)/Ce(III) in the NTA solution. The value was in good accordance with the stability constant of the Np{sup IV}(nta){sub 2}{sup 2-} complex, demonstrating that the aqueous coordination chemistry of Ce(IV) with NTA is quite similar to that of An(IV). These results strongly suggest that a negative shift of the Pu(IV)/Pu(III) redox potential in the NTA solution should make Pu(IV) more stable than Pu(III) even in a reducing environment.

  19. Cytogenetic studies of chromium (III) oxide nanoparticles on Allium cepa root tip cells.

    PubMed

    Kumar, Deepak; Rajeshwari, A; Jadon, Pradeep Singh; Chaudhuri, Gouri; Mukherjee, Anita; Chandrasekaran, Natarajan; Mukherjee, Amitava

    2015-12-01

    The current study evaluates the cytogenetic effects of chromium (III) oxide nanoparticles on the root cells of Allium cepa. The root tip cells of A. cepa were treated with the aqueous dispersions of Cr2O3 nanoparticles (NPs) at five different concentrations (0.01, 0.1, 1, 10, and 100μg/mL) for 4hr. The colloidal stability of the nanoparticle suspensions during the exposure period were ascertained by particle size analyses. After 4hr exposure to Cr2O3 NPs, a significant decrease in mitotic index (MI) from 35.56% (Control) to 35.26% (0.01μg/mL), 34.64% (0.1μg/mL), 32.73% (1μg/mL), 29.6% (10μg/mL) and 20.92% (100μg/mL) was noted. The optical, fluorescence and confocal laser scanning microscopic analyses demonstrated specific chromosomal aberrations such as-chromosome stickiness, chromosome breaks, laggard chromosome, clumped chromosome, multipolar phases, nuclear notch, and nuclear bud at different exposure concentrations. The concentration-dependent internalization/bio-uptake of Cr2O3 NPs may have contributed to the enhanced production of anti oxidant enzyme, superoxide dismutase to counteract the oxidative stress, which in turn resulted in observed chromosomal aberrations and cytogenetic effects. These results suggest that A. cepa root tip assay can be successfully applied for evaluating environmental risk of Cr2O3 NPs over a wide range of concentrations. PMID:26702979

  20. Structural and photophysical studies on gallium(III) 8-hydroxyquinoline-5-sulfonates. Does excited state decay involve ligand photolabilisation?

    PubMed

    Ramos, M Luísa; de Sousa, Andreia R E; Justino, Licínia L G; Fonseca, Sofia M; Geraldes, Carlos F G C; Burrows, Hugh D

    2013-03-14

    Multinuclear ((1)H, (13)C and (71)Ga) magnetic resonance spectroscopy (1D and 2D), DFT calculations and luminescence techniques have been used to study 8-hydroxyquinoline-5-sulfonate (8-HQS) and its complexes with Ga(III) in aqueous solutions. The study combines the high sensitivity of luminescence techniques and the selectivity of multinuclear NMR spectroscopy with the structural details accessible through DFT calculations, and aims to obtain a complete understanding of the complexation between the Ga(3+) ion and 8-HQS, and how this influences the luminescence behaviour. A full speciation study has been performed on this system and three complexes detected, with (metal : ligand) 1 : 1, 1 : 2 and 1 : 3 stoichiometries, the results being consistent with those previously found for the system Al(III)-8-HQS. Complexation in these systems is relevant to their potential biomedical, sensing and optoelectronic applications. On binding to Ga(III), a marked increase is seen in the intensity of the 8-HQS fluorescence band, which is accompanied by changes in the absorption spectra. These support the use of 8-HQS as a sensitive fluorescent sensor to detect Ga(3+) metal ions in surface waters, biological fluids, etc., and its metal complexes as an emitting or charge transport layer in light emitting devices. However, the fluorescence quantum yield of the Ga(III)-8-HQS 1 : 3 complex is about 35% of that of the corresponding system with Al(III). Although this may be due in part to a heavy atom effect favouring S(1)→ T(1) intersystem crossing with Ga(3+), this does not agree with transient absorption measurements on the triplet state yield, which is lower with the Ga(III) system than with Al(III). Instead, it is suggested that photolabilisation of ligand exchange plays a major role in nonradiative decay of the excited state and that this is more efficient with the Ga(3+) complex. Based on these results, suggestions are made of ways of enhancing fluorescence

  1. Structural and photophysical studies on gallium(III) 8-hydroxyquinoline-5-sulfonates. Does excited state decay involve ligand photolabilisation?

    PubMed

    Ramos, M Luísa; de Sousa, Andreia R E; Justino, Licínia L G; Fonseca, Sofia M; Geraldes, Carlos F G C; Burrows, Hugh D

    2013-03-14

    Multinuclear ((1)H, (13)C and (71)Ga) magnetic resonance spectroscopy (1D and 2D), DFT calculations and luminescence techniques have been used to study 8-hydroxyquinoline-5-sulfonate (8-HQS) and its complexes with Ga(III) in aqueous solutions. The study combines the high sensitivity of luminescence techniques and the selectivity of multinuclear NMR spectroscopy with the structural details accessible through DFT calculations, and aims to obtain a complete understanding of the complexation between the Ga(3+) ion and 8-HQS, and how this influences the luminescence behaviour. A full speciation study has been performed on this system and three complexes detected, with (metal : ligand) 1 : 1, 1 : 2 and 1 : 3 stoichiometries, the results being consistent with those previously found for the system Al(III)-8-HQS. Complexation in these systems is relevant to their potential biomedical, sensing and optoelectronic applications. On binding to Ga(III), a marked increase is seen in the intensity of the 8-HQS fluorescence band, which is accompanied by changes in the absorption spectra. These support the use of 8-HQS as a sensitive fluorescent sensor to detect Ga(3+) metal ions in surface waters, biological fluids, etc., and its metal complexes as an emitting or charge transport layer in light emitting devices. However, the fluorescence quantum yield of the Ga(III)-8-HQS 1 : 3 complex is about 35% of that of the corresponding system with Al(III). Although this may be due in part to a heavy atom effect favouring S(1)→ T(1) intersystem crossing with Ga(3+), this does not agree with transient absorption measurements on the triplet state yield, which is lower with the Ga(III) system than with Al(III). Instead, it is suggested that photolabilisation of ligand exchange plays a major role in nonradiative decay of the excited state and that this is more efficient with the Ga(3+) complex. Based on these results, suggestions are made of ways of enhancing fluorescence

  2. Subcellular Relocalization and Positive Selection Play Key Roles in the Retention of Duplicate Genes of Populus Class III Peroxidase Family[W][OPEN

    PubMed Central

    Ren, Lin-Ling; Liu, Yan-Jing; Liu, Hai-Jing; Qian, Ting-Ting; Qi, Li-Wang; Wang, Xiao-Ru; Zeng, Qing-Yin

    2014-01-01

    Gene duplication is the primary source of new genes and novel functions. Over the course of evolution, many duplicate genes lose their function and are eventually removed by deletion. However, some duplicates have persisted and evolved diverse functions. A particular challenge is to understand how this diversity arises and whether positive selection plays a role. In this study, we reconstructed the evolutionary history of the class III peroxidase (PRX) genes from the Populus trichocarpa genome. PRXs are plant-specific enzymes that play important roles in cell wall metabolism and in response to biotic and abiotic stresses. We found that two large tandem-arrayed clusters of PRXs evolved from an ancestral cell wall type PRX to vacuole type, followed by tandem duplications and subsequent functional specification. Substitution models identified seven positively selected sites in the vacuole PRXs. These positively selected sites showed significant effects on the biochemical functions of the enzymes. We also found that positive selection acts more frequently on residues adjacent to, rather than directly at, a critical active site of the enzyme, and on flexible regions rather than on rigid structural elements of the protein. Our study provides new insights into the adaptive molecular evolution of plant enzyme families. PMID:24934172

  3. Open-Source Software in Computational Research: A Case Study

    DOE PAGES

    Syamlal, Madhava; O'Brien, Thomas J.; Benyahia, Sofiane; Gel, Aytekin; Pannala, Sreekanth

    2008-01-01

    A case study of open-source (OS) development of the computational research software MFIX, used for multiphase computational fluid dynamics simulations, is presented here. The verification and validation steps required for constructing modern computational software and the advantages of OS development in those steps are discussed. The infrastructure used for enabling the OS development of MFIX is described. The impact of OS development on computational research and education in gas-solids flow, as well as the dissemination of information to other areas such as geophysical and volcanology research, is demonstrated. This study shows that the advantages of OS development were realized inmore » the case of MFIX: verification by many users, which enhances software quality; the use of software as a means for accumulating and exchanging information; the facilitation of peer review of the results of computational research.« less

  4. System studies of open-cycle OTEC components

    SciTech Connect

    Parsons, B K; Link, H F

    1985-09-01

    A system model of open Rankine cycle ocean thermal energy conversion (OC-OTEC) was used to examine the effects of component performance and design on plant cost. Three components are examined in detail: an optional seawater deaeration subsystem, the flash evaporator, and a two-stage direct-contact condenser. Preliminary data quantifying noncondensable gas release in upcomers and a debubbler chamber were used to evaluate the effect of predeaeration (removing the dissolved gases in deaeration chambers before the seawater enters the heat exchangers) on system cost and performance. Little data on the interactions between geometry and performance of vertical spout flash evaporators operating under OTEC conditions are available; therefore, we performed independent parametric variations. For the direct-contact condenser previous numerical studies provide the basis for coupling geometry and performance. Results of these studies are useful in setting research priorities, in defining operating conditions for further seawater experiments, and in updating plant cost estimates.

  5. A Phase III Study of Durvalumab (MEDI4736) With or Without Tremelimumab for Previously Treated Patients With Advanced NSCLC: Rationale and Protocol Design of the ARCTIC Study.

    PubMed

    Planchard, David; Yokoi, Takashi; McCleod, Michael J; Fischer, Jürgen R; Kim, Young-Chul; Ballas, Marc; Shi, Kelvin; Soria, Jean-Charles

    2016-05-01

    Anti-programmed cell death-1 and anti-programmed cell death ligand-1 (PD-L1) monotherapies have shown promising clinical activity in advanced, refractory non-small-cell lung cancer (NSCLC), but antitumor activity appears to be greater in patients with PD-L1(+) tumors compared with patients harboring PD-L1(-) tumors. Combining the anti-PD-L1 antibody durvalumab and the anti-cytotoxic T-lymphocyte antigen 4 antibody tremelimumab offers the potential for antitumor activity in patients with advanced NSCLC, regardless of PD-L1 tumor status. ARCTIC (NCT02352948) is a global, phase III, randomized, open-label multicenter study in patients with advanced NSCLC assessing the safety and clinical activity of durvalumab versus standard of care (SoC; erlotinib, gemcitabine, or vinorelbine) in patients with PD-L1(+) tumors (≥25% of tumor cells with membrane staining using VENTANA PD-L1 [SP263] CDx Assay) (Sub-study A) and the combination of durvalumab + tremelimumab or either agent as monotherapy versus SoC in patients with PD-L1(-) tumors (Sub-study B). Eligible patients are those with locally advanced or metastatic NSCLC (Stage IIIB/IV), without epidermal growth factor receptor tyrosine kinase activating mutations or anaplastic lymphoma kinase rearrangements, who have received at least 2 prior systemic regimens, including 1 platinum-based chemotherapy regimen. Co-primary endpoints are progression-free survival and overall survival. Secondary endpoints include the proportion of patients alive at 12 months, objective response rate, duration of response, progression-free survival at 6 and 12 months, safety and tolerability, pharmacokinetics, immunogenicity, and quality of life. The exploratory endpoints will assess potential biomarkers of treatment response. Recruitment started in January 2015 and is ongoing. PMID:27265743

  6. A Phase III Study of Durvalumab (MEDI4736) With or Without Tremelimumab for Previously Treated Patients With Advanced NSCLC: Rationale and Protocol Design of the ARCTIC Study.

    PubMed

    Planchard, David; Yokoi, Takashi; McCleod, Michael J; Fischer, Jürgen R; Kim, Young-Chul; Ballas, Marc; Shi, Kelvin; Soria, Jean-Charles

    2016-05-01

    Anti-programmed cell death-1 and anti-programmed cell death ligand-1 (PD-L1) monotherapies have shown promising clinical activity in advanced, refractory non-small-cell lung cancer (NSCLC), but antitumor activity appears to be greater in patients with PD-L1(+) tumors compared with patients harboring PD-L1(-) tumors. Combining the anti-PD-L1 antibody durvalumab and the anti-cytotoxic T-lymphocyte antigen 4 antibody tremelimumab offers the potential for antitumor activity in patients with advanced NSCLC, regardless of PD-L1 tumor status. ARCTIC (NCT02352948) is a global, phase III, randomized, open-label multicenter study in patients with advanced NSCLC assessing the safety and clinical activity of durvalumab versus standard of care (SoC; erlotinib, gemcitabine, or vinorelbine) in patients with PD-L1(+) tumors (≥25% of tumor cells with membrane staining using VENTANA PD-L1 [SP263] CDx Assay) (Sub-study A) and the combination of durvalumab + tremelimumab or either agent as monotherapy versus SoC in patients with PD-L1(-) tumors (Sub-study B). Eligible patients are those with locally advanced or metastatic NSCLC (Stage IIIB/IV), without epidermal growth factor receptor tyrosine kinase activating mutations or anaplastic lymphoma kinase rearrangements, who have received at least 2 prior systemic regimens, including 1 platinum-based chemotherapy regimen. Co-primary endpoints are progression-free survival and overall survival. Secondary endpoints include the proportion of patients alive at 12 months, objective response rate, duration of response, progression-free survival at 6 and 12 months, safety and tolerability, pharmacokinetics, immunogenicity, and quality of life. The exploratory endpoints will assess potential biomarkers of treatment response. Recruitment started in January 2015 and is ongoing.

  7. Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

    NASA Astrophysics Data System (ADS)

    Kostova, Irena; Peica, Niculina; Kiefer, Wolfgang

    2006-09-01

    The lanthanum (III) complex of 5-aminoorotic acid (HAOA) was synthesized and its structure was determined by means of elemental analysis and IR, Raman, and 1H NMR spectroscopies. Significant differences in the IR, Raman, and 1H NMR spectra of the complex were observed as compared to the spectra of the ligand. The geometry of 5-aminoorotic acid was computed and optimized with the Gaussian 03 program employing the B3PW91 and B3LYP methods with the 6-311++G and LANL2DZ basis sets, while the geometry of the La(III) complex of 5-aminoorotic acid was also calculated and optimized with B3PW91/LANL2DZ and B3LYP/LANL2DZ methods. The density functional calculations revealed that the binding mode in the complex was bidentate through the carboxylic oxygen atoms. Detailed vibrational analysis of HAOA and La(III)-AOA systems based on both the calculated and experimental spectra confirmed the suggested metal-ligand binding mode. The density functional theory (DFT) calculated geometries, harmonic vibrational wavenumbers including IR and Raman scattering activities for the ligand and its La(III) complex were in good agreement with the experimental data, a complete vibrational assignment being proposed.

  8. Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders

    ClinicalTrials.gov

    2016-04-05

    Hurler Syndrome (MPS I); Hurler-Scheie Syndrome With Early Neurologic Involvement and/or Sensitization to Enzyme Replacement Therapy (ERT); Hunter Syndrome (MPS II); Sanfilippo Syndrome (MPS III); Krabbe Disease (Globoid Leukodystrophy); Metachromatic Leukodystrophy (MLD); Adrenoleukodystrophy (ALD and AMN); Sandhoff Disease; Tay Sachs Disease; Pelizaeus Merzbacher (PMD); Niemann-Pick Disease; Alpha-mannosidosis

  9. X-ray studies of III-V native oxide/gallium arsenide interface

    NASA Astrophysics Data System (ADS)

    Cheong, Seong-Kyun

    Three x-ray techniques have been employed to study wet-thermal native oxides of AlGaAs on GaAs. For these materials, a knowledge of the role of As at the interface is important for understanding Fermi-level pinning and is a central issue in efforts to develop high performance III-V MOSFET devices. This study is focused on how the As is incorporated at the interface, the interfacial strain, and related local structural parameters. X-ray absorption fine-structure spectroscopy (XAFS) was used to determine the site of residual As in wet-oxidized Al0.96Ga0.04As. In a ˜0.5 mum oxide film removed from its GaAs substrate, the remaining As atoms were found to be coordinated with oxygen in the form of amorphous As oxides, with a mixture of ˜80% As3+ and ˜20% As 5+ sites. These two sites are locally similar to As2O 3 and As2O5. Through this measurement, no evidence of interstitial or substitutional As, As precipitates, or GaAs was seen, implying that less than 10% of the As atoms are in these forms. To characterize the oxide structure in both the oxide film and the interfacial region, x-ray reflectivity and reflection-mode XAFS experiments were performed for a thin (300 A) oxidized AlxGa1-xAs (x = 0.96) film grown on GaAs. X-ray reflectivity studies showed that the composition of the surface oxidized film is not homogeneous as a function of depth. Reflection-mode XAFS, which uses the total external reflection of x-rays to confine an x-ray beam to the interfacial region, provided details of the local environment of As atoms at the interface of the oxide/GaAs. Analysis through this technique revealed that As atoms are in the form of mixed As oxides, with the local environment appearing to resemble As2O3 and As 2O5 in the interfacial region, which is consistent with the above observation from the isolated oxide film.

  10. The periodontal tissues in healed degree III furcation defects. An experimental study in dogs.

    PubMed

    Araújo, M; Berglundh, T; Lindhe, J

    1996-06-01

    The aim of the present study was (i) to describe the periodontal tissue that formed in degree III furcation defects in mandibular molars of dogs following GTR therapy and (ii) to compare this healed periodontium to the corresponding tissue of pristine furcations. The study was performed in 10 mongrels dogs. In 6 of the dogs (group A), the 2nd and 4th premolars in both sides of the mandible were extracted 2 months prior to the start of the study. The 4 remaining dogs (group B) were used as normal untreated controls. In the dogs of group A, a furcation defect was produced in the 3rd mandibular premolars and reconstructive surgery was later performed in accordance with the GTR technique. 5 months after reconstructive surgery, all 10 animals (groups A+B) were sacrificed and perfused with a solution of 10% neutral, buffered formalin through the carotid arteries. Tissue blocks containing the experimental teeth were excised, demineralized in EDTA, embedded in paraffin. Serial sections were cut in the mesiodistal plane and parallel with the long axis of the roots. The microtome was set at 7 microns. The sections were stained in hematoxyline and eosin or Van Gieson's connective tissue staining. From each biopsy, 3 sections, 14 microns apart, and representing the central part of the furcation, were selected for light microscopic examination. In the healed furcation sites, histometric and morphometric measurements were performed at different levels (zones), either at the mesial or distal root surfaces; (zone 1) immediately apical of the notch; (zone 2) coronal to the notch where the newly formed alveolar bone was in continuity with the reduced bone crest; (zone 3) coronal to the notch; representing the most coronally positioned area of new bone formation; (zone 4) coronal to the notch; representing areas with no alveolar bone present. In the pristine furcation sites, the measurements were made at zones which corresponded to the location of the zones in the healed furcations

  11. SAGE III

    Atmospheric Science Data Center

    2016-06-15

    SAGE III Data and Information The Stratospheric Aerosol and Gas ... on the spacecraft. SAGE III produced L1 and L2 scientific data from 5/07/2002 until 12/31/2005. The flight of the second instrument is as ... Guide Documents:  Project Guide Data Products User's Guide  (PDF) Relevant Documents:  ...

  12. How to Study. A Guide to Studying at the Open University.

    ERIC Educational Resources Information Center

    Open Univ., Walton, Bletchley, Bucks (England).

    This guide to studying at the Open University concerns the problems of independent learning for the adult student. Working effectively as a student requires clear and realistic goals, support from close contacts at home and work, a business-like approach, and a desire to learn. Study techniques covered are when and where to study, how to read…

  13. Application of TAM III to study sensitivity of soil organic matter degradation to temperature

    NASA Astrophysics Data System (ADS)

    Vikegard, Peter; Barros, Nieves; Piñeiro, Verónica

    2014-05-01

    Traditionally, studies of soil biodegradation are based on CO2 dissipation rates. CO2 is a product of aerobic degradation of labile organic substrates like carbohydrates. That limits the biodegradation concept to just one of the soil organic matter fractions. This feature is responsible for some problems to settle the concept of soil organic matter (SOM) recalcitrance and for controversial results defining sensitivity of SOM to temperature. SOM consists of highly complex macromolecules constituted by fractions with different chemical nature and redox state affecting the chemical nature of biodegradation processes. Biodegradation of fractions more reduced than carbohydrates take place through metabolic pathways that dissipate less CO2 than carbohydrate respiration, that may not dissipate CO2, or that even may uptake CO2. These compounds can be considered more recalcitrant and with lower turnover times than labile SOM just because they are degraded at lower CO2 rates that may be just a consequence of the metabolic path. Nevertheless, decomposition of every kind of organic substrate always releases heat. For this reason, the measurement of the heat rate by calorimetry yields a more realistic measurement of the biodegradation of the SOM continuum. TAM III is one of the most recent calorimeters designed for directly measuring in real time the heat rate associated with any degradation process. It is designed as a multichannel system allowing the concomitant measurement of to up 24 samples at isothermal conditions or through a temperature scanning mode from 18 to 100ºC, allowing the continous measure of any sample at controlled non-isothermal conditions. The temperature scanning mode was tested in several soil samples collected at different depths to study their sensitivity to temperature changes from 18 to 35 ºC calculating the Q10 and the activation energy (EA) by the Arrhenius equation. It was attempted to associate the obtained EA values with the soil thermal

  14. Reactivity of Chromium(III) Nutritional Supplements in Biological Media: An X-Ray Absorption Spectroscopic Study

    SciTech Connect

    Nguyen, A.; Mulyani, I.; Levina, A.; Lay, P.A.

    2009-05-22

    Chromium(III) nutritional supplements are widely used due to their purported ability to enhance glucose metabolism, despite growing evidence on low activity and the potential genotoxicity of these compounds. Reactivities of Cr(III) complexes used in nutritional formulations, including [Cr3O(OCOEt)6(OH2)3]+ (A), [Cr(pic)3] (pic) = 2-pyridinecarboxylato(-) (B), and trans-[CrCl2(OH2)4]+ (CrCl3 {center_dot} 6H2O; C), in a range of natural and simulated biological media (artificial digestion systems, blood and its components, cell culture media, and intact L6 rat skeletal muscle cells) were studied by X-ray absorption near-edge structure (XANES) spectroscopy. The XANES spectroscopic data were processed by multiple linear-regression analyses with the use of a library of model Cr(III) compounds, and the results were corroborated by the results of X-ray absorption fine structure spectroscopy and electrospray mass spectrometry. Complexes A and B underwent extensive ligand-exchange reactions under conditions of combined gastric and intestinal digestion (in the presence of a semisynthetic meal, 3 h at 310 K), as well as in blood serum and in a cell culture medium (1-24 h at 310 K), with the formation of Cr(III) complexes with hydroxo and amino acid/protein ligands. Reactions of compounds A-C with cultured muscle cells led to similar ligand-exchange products, with at least part of Cr(III) bound to the surface of the cells. The reactions of B with serum greatly enhanced its propensity to be converted to Cr(VI) by biological oxidants (H2O2 or glucose oxidase system), which is proposed to be a major cause of both the insulin-enhancing activity and toxicity of Cr(III) compounds (Mulyani, I.; Levina, A.; Lay, P. A. Angew. Chem. Int. Ed. 2004, 43, 4504-4507). This finding enhances the current concern over the safety of consumption of large doses of Cr(III) supplements, particularly [Cr(pic)3].

  15. Autologous Bone Marrow Mononuclear Cell Therapy for Autism: An Open Label Proof of Concept Study

    PubMed Central

    Sharma, Alok; Gokulchandran, Nandini; Sane, Hemangi; Nagrajan, Anjana; Kulkarni, Pooja; Shetty, Akshata; Mishra, Priti; Kali, Mrudula; Biju, Hema; Badhe, Prerna

    2013-01-01

    Cellular therapy is an emerging therapeutic modality with a great potential for the treatment of autism. Recent findings show that the major underlying pathogenetic mechanisms of autism are hypoperfusion and immune alterations in the brain. So conceptually, cellular therapy which facilitates counteractive processes of improving perfusion by angiogenesis and balancing inflammation by immune regulation would exhibit beneficial clinical effects in patients with autism. This is an open label proof of concept study of autologous bone marrow mononuclear cells (BMMNCs) intrathecal transplantation in 32 patients with autism followed by multidisciplinary therapies. All patients were followed up for 26 months (mean 12.7). Outcome measures used were ISAA, CGI, and FIM/Wee-FIM scales. Positron Emission Tomography-Computed Tomography (PET-CT) scan recorded objective changes. Out of 32 patients, a total of 29 (91%) patients improved on total ISAA scores and 20 patients (62%) showed decreased severity on CGI-I. The difference between pre- and postscores was statistically significant (P < 0.001) on Wilcoxon matched-pairs signed rank test. On CGI-II 96% of patients showed global improvement. The efficacy was measured on CGI-III efficacy index. Few adverse events including seizures in three patients were controlled with medications. The encouraging results of this leading clinical study provide future directions for application of cellular therapy in autism. PMID:24062774

  16. Experimental and numerical study of open-air active cooling

    NASA Astrophysics Data System (ADS)

    Al-Fifi, Salman Amsari

    The topic of my thesis is Experimental and Numerical Study of Open Air Active Cooling. The present research is intended to investigate experimentally and Numerically the effectiveness of cooling large open areas like stadiums, shopping malls, national gardens, amusement parks, zoos, transportation facilities and government facilities or even in buildings outdoor gardens and patios. Our cooling systems are simple cooling fans with different diameters and a mist system. This type of cooling systems has been chosen among the others to guarantee less energy consumption, which will make it the most favorable and applicable for cooling such places mentioned above. In the experiments, the main focus is to study the temperature domain as a function of different fan diameters aerodynamically similar in different heights till we come up with an empirical relationship that can determine the temperature domain for different fan diameters and for different heights of these fans. The experimental part has two stages. The first stage is devoted to investigate the maximum range of airspeed and profile for three different fan diameters and for different heights without mist, while the second stage is devoted to investigate the maximum range of temperature and profile for the three different diameter fans and for different heights with mist. The computational study is devoted to built an experimentally verified mathematical model to be used in the design and optimization of water mist cooling systems, and to compare the mathematical results to the experimental results and to get an insight of how to apply such evaporative mist cooling for different places for different conditions. In this study, numerical solution is presented based on experimental conditions, such dry bulb temperature, wet bulb temperature, relative humidity, operating pressure and fan airspeed. In the computational study, all experimental conditions are kept the same for the three fans except the fan airspeed

  17. Mössbauer study on the gamma radiolysis of anhydrous cesium tris (oxalato) ferrate(III)

    NASA Astrophysics Data System (ADS)

    Ladriere, J.; Senterre, V.; Apers, D.

    1992-04-01

    The final product of the gamma radiolysis of anhydrous cesium tris(oxalato) ferrate(III) has been identified by Mössbauer spectroscopy as Cs2Fe(ox)2. The radiolytic decomposition proceeds as a first-order process due to the original compound depletion and to the radiolytic stability of the ferrous compound. Lamb-Mössbauer factors measurements indicate that the recoilless fractions of the iron species are practically unaffected by the radiolysis.

  18. Synthesis, structure and spectroscopic study of Rh III polypyridine complexes with phenylcyanamide derivative ligands

    NASA Astrophysics Data System (ADS)

    Hadadzadeh, Hassan; Rezvani, Ali R.; Belanger-Gariepy, Francine

    2005-04-01

    Several new Rh III complexes, [Rh(tpy)(bpy)L](PF 6) 2 (tpy=2,2':6',2″-terpyridine, bpy=2,2'-bipyridine, and L=monoanions of phenylcyanamide(pcyd)), 4-methylphenylcyanamide (4-MePcyd), 2,4-dimethylphenylcyanamide (2,4-Me 2pcyd), 4-methoxyphenylcyanamide (4-MeOPcyd), 2-chlorophenylcyanamide (2-Clpcyd) and 2,5-dichlorophenylcyanamide (2,5-Cl 2pcyd) have been synthesized and characterized by elemental analysis, IR, 1H NMR and electronic absorption spectroscopies. ORTEP drawing of [Rh(tpy)(bpy)(2,5-Cl 2pcyd)](PF 6) 2·1/2CH 3CN shows three pyridyl rings of the tpy ligand that are nearly coplanar, as are the two rings of bpy. The anionic cyanamide group is coordinated end-on by the nitrile nitrogen to the Rh III. The Rh III-NCN bond is bent, having an angle of 125.4°. This bent bond is largely determined by the σ-bonding interaction of a cyanamide non-bonding electron pair in a sp 2 hybrid orbital.

  19. Thermal stability of porcine pepsin influenced by Al(III) ion: DSC study

    NASA Astrophysics Data System (ADS)

    Pavelkić, V. M.; Beljanski, M. V.; Antić, K. M.; Babić, M. M.; Brdarić, T. P.; Gopčević, K. R.

    2011-12-01

    Differential scanning calorimetry (DCS) has been used to determine thermodynamic profile of pepsin and the in vitro effect of Al(III) ions. Thermograms of pepsin unfolding in the presence and absence of aluminum were used to determine the binding constant, K L, in the pepsin-aluminium model system. The thermodynamic parameters were derived from DSC profiles at different ligand concentrations (1, 5 and 10 mM). The temperatures of thermal transitions ( T m), calorimetric (Δ H cal) and van't Hoff enthalpy (Δ H VH), Gibbs free energy, Δ(Δ G), of Al(III) binding to pepsin, as well as an average number of ligands bound to the native protein, were obtained from DSC profiles too. Temperature-dependent changes in the protein structure were also monitored by native PAGE electrophoresis. Increasing the temperature causes the decrease in electrophoretic mobility. Increase in concentration of Al(III) decelerate the migration of pepsin samples on concentration dependent manner. Analysis showed that ligand binding increases thermal stability of protein.

  20. Deuterium NMR study of amino acid coordination to chromium(III)

    SciTech Connect

    Green, C.A.; Place, H.; Willett, R.D.; Legg, J.I.

    1986-12-17

    A series of bis(ethylenediamine)Cr(III)-amino acid complexes, synthesized with deuterium-labeled alanine, glycine, homoserine, leucine, methionine, phenylalanine, serine, and threonine, was characterized by /sup 2/H NMR spectroscopy. The spectra show that these bidentate-coordinated amino acid complexes decompose via monodentate species. In addition, the diastereomeric isomers of alanine and leucine can be distinguished in the spectra. This was confirmed by the isolation of one of the L-leucine isomers. The bis(1,3-propanediamine)Cr(III) complexes of glycine and alanine were also synthesized, and the NMR spectra of these complexes and ..cap alpha..-cis-(Cr(ethylenediaminediacetate)(glycinate)) show changes due to variation in the ligand complement. The crystal structure of ..cap alpha..-cis(Cr(ethylenediaminediacetate)(glycinate)) x 2H/sub 2/O (CrO/sub 6/N/sub 3/C/sub 8/H/sub 14/ x 2H/sub 2/O) was determined and supports the NMR observations. This complex crystallizes in the space group P2/sub 1//c of the monoclinic crystal system with a = 8.9231 (19) A, b = 10.1889 (22) A, c = 15.4180 (30) A, ..beta.. = 102.657 (17)/sup 0/, and Z = 4. An improved method for the synthesis of bis(diamine)Cr(III)-amino acid complexes is also reported. 24 references, 3 figures, 7 tables.

  1. Robust electrochemical analysis of As(III) integrating with interference tests: a case study in groundwater.

    PubMed

    Liu, Zhong-Gang; Chen, Xing; Liu, Jin-Huai; Huang, Xing-Jiu

    2014-08-15

    In Togtoh region of Inner Mongolia, northern China, groundwater encountered high concentrations As contamination (greater than 50 μg L(-1)) causes an increasing concern. This work demonstrates an electrochemical protocol for robust (efficient and accurate) determination of As(III) in Togtoh water samples using Au microwire electrode without the need of pretreatment or clean-up steps. Considering the complicated conditions of Togtoh water, the efficiency of Au microwire electrode was systematically evaluated by a series of interference tests, stability and reproducibility measurements. No obvious interference on the determination of As(III) was observed. Especially, the influence of humic acid (HA) was intensively investigated. Electrode stability was also observed with long-term measurements (70 days) in Togtoh water solution and under different temperatures (0-35 °C). Excellent reproducibility (RSD:1.28%) was observed from different batches of Au microwire electrodes. The results obtained at Au microwire electrode were comparable to that obtained by inductively coupled plasma atomic emission spectroscopy (ICP-AES), indicating a good accuracy. These evaluations (efficiency, robustness, and accuracy) demonstrated that the Au microwire electrode was able to determine As(III) in application to real environmental samples.

  2. Spectroscopic and quantum chemical study of the structure of a new paramagnetic dimeric palladium(II,III) complex with creatine

    NASA Astrophysics Data System (ADS)

    Mitewa, Mariana; Enchev, Venelin; Bakalova, Tatyana

    2002-05-01

    The structure and coordination mode of the newly synthesized dimeric paramagnetic Pd(II,III) complex are studied using magneto-chemical, EPR and IR spectroscopic methods. In order to perform reliable assignment of the IR bands, the structure and IR spectrum of the free creatine were calculated using ab initio method. For calculation of the configuration of its deprotonated and doubly deprotonated forms the semiempirical AM1 method was used.

  3. Complexation of Eu(III) with cucurbit[n]uril, n = 5 and 7: a thermodynamic and structural study.

    PubMed

    Rawat, Neetika; Kar, Aishwarya; Bhattacharyya, A; Rao, Ankita; Nayak, S K; Nayak, C; Jha, S N; Bhattacharyya, D; Tomar, B S

    2015-03-01

    Cucurbit[n]urils (CBn) are a new class of macrocyclic cage compounds capable of binding organic and inorganic species, owing to their unique pumpkin like structure comprising of both a hydrophobic cavity and a hydrophilic portal. The thermodynamics of the complexation of Eu(III) with CBn of a different cavity size viz. cucurbit[5]uril (CB5) and cucurbit[7]uril (CB7) has been studied by UV-Vis spectroscopy and calorimetry at 25 °C whereas the structure of the complexes was investigated using time resolved fluorescence spectroscopy (TRFS) and extended X-ray absorption fine structure spectroscopy (EXAFS) in a formic acid-water mixture (50 wt%). This is the first report on the structural investigation of Eu-CBn complexes in solution. The thermodynamic data (ΔG, ΔH and ΔS) for Eu(III) complexation with CBn reveal the formation of a 1 : 1 complex with CB5, while both 1 : 1 and 1 : 2 complexes are observed with CB7. The signatures of these species are observed in ESI-MS measurements, which corroborates with the species postulated in thermodynamic studies. The complexation reactions are found to be driven by ΔS as ΔH is either small negative or positive indicating the formation of inner sphere complexes, which is in line with TRFS and EXAFS results. These studies show that Eu(III) caps one of the CB5 portals by binding with all the carbonyl groups in the 1 : 1 Eu-CB5 complex, whereas in the 1 : 1 Eu-CB7 complex, Eu(III) interacts with only a few of the carbonyl groups of CB7. The computational studies (DFT calculations) on Eu-CB5 and Eu-CB7 complexes further support the experimental data.

  4. Erratum: Erratum to: Axial Imidazole Binding Strengths in Porphyrinoid Cobalt(III) Complexes as Studied by Tandem Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Mishra, Ekta; Worlinsky, Jill L.; Gilbert, Thomas M.; Brückner, Christian; Ryzhov, Victor

    2012-08-01

    The Co(II) complexes of twelve meso-tetraaryl-porphyrins, -chlorins, and chlorin analogues containing non-pyrrolic heterocycles were synthesized and converted in situ to the corresponding Co(III) complexes coordinated to one or two imidazoles. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) in conjunction with the energy-variable collision-induced dissociation (CID) technique was used to compare the relative gas-phase binding strength of the axially coordinated imidazoles to the octahedral and square planar Co(III) porphyrinoid complex ions. The observed binding energies of these ligands were rationalized in terms of the effects of porphyrinoid core structure and meso-substitution on the electron density on the central Co(III) centers. Some of these trends were supported by DFT-based computational studies. The study highlights to which extend porphyrins vary from chlorins and chlorin analogues in their coordination abilities and to which extraordinary degree meso-thienyl-substituents influence the electronic structure of porphyrins. The study also defines further the scope and limits CID experiments can be used to interrogate the electronic structures of metalloporphyrin complexes.

  5. Lesbian, Gay, and Heterosexual Couples in Open Adoption Arrangements: A Qualitative Study

    ERIC Educational Resources Information Center

    Goldberg, Abbie E.; Kinkler, Lori A.; Richardson, Hannah B.; Downing, Jordan B.

    2011-01-01

    Little research has attended to the role of gender and sexual orientation in shaping open adoption dynamics. This qualitative, longitudinal study of 45 adoptive couples (15 lesbian, 15 gay, and 15 heterosexual couples) examined adopters' motivations for open adoption, changes in attitudes about openness, and early relationship dynamics. Key…

  6. A Bibliometric Study of Scholarly Articles Published by Library and Information Science Authors about Open Access

    ERIC Educational Resources Information Center

    Grandbois, Jennifer; Beheshti, Jamshid

    2014-01-01

    Introduction: This study aims to gain a greater understanding of the development of open access practices amongst library and information science authors, since their role is integral to the success of the broader open access movement. Method: Data were collected from scholarly articles about open access by library and information science authors…

  7. Spectroscopic study on the role of TiO{sub 2} in the adsorption of Eu(III) and U(VI) on silica surfaces in aqueous solutions

    SciTech Connect

    Im, Hee-Jung Park, Kyoung Kyun; Jung, Euo Chang

    2014-10-15

    Highlights: • Enhanced adsorption of Eu(III) and U(VI) onto TiO{sub 2}-coated silica. • Enhanced Eu(III) luminescence and lifetime on TiO{sub 2}-coated silica. • Energy transfer from TiO{sub 2} of TiO{sub 2}-coated silica to Eu(III) in solutions. - Abstract: To determine the effects of TiO{sub 2} on the adsorption of actinides onto mineral surfaces in groundwater, silica was partially coated with TiO{sub 2}, and Eu(III) and U(VI) were individually adsorbed from separate 0.1 mM concentration solutions. The TiO{sub 2}-coated silica showed higher Eu(III) and U(VI) adsorption capacities for increasing amounts of TiO{sub 2} coated on the silica surfaces, and thus the existence of TiO{sub 2} can decrease the mobility of Eu(III) and U(VI) contaminants. In luminescence studies, it was found that TiO{sub 2} considerably enhanced the luminescence of the adsorbed Eu(III) indicating that TiO{sub 2}–Eu(III) forms surface complexes which may decrease the number of water molecules at the inner sphere of Eu(III), but this was not observed for U(VI). An energy transfer from the TiO{sub 2} to the Eu(III) was confirmed in this case of amorphous TiO{sub 2}-coated silica in Eu(III) solutions, and an increase of the luminescence lifetime of Eu(III) for increasing concentrations of coated TiO{sub 2} was also observed.

  8. From OCW to MOOC: Deployment of OERs in a Massive Open Online Course. The Experience of Universidad Carlos III de Madrid (UC3M)

    ERIC Educational Resources Information Center

    Fernández, José Vida; Webster, Susan

    2014-01-01

    The emergence of Massive Open Online Courses (MOOCs) is focusing all its attention on open education. There is growing interest in creating MOOCs, which can be done by transferring OCW courses to MOOC format. However, a series of doubts arise regarding the pros and cons implied in this transformation. In this paper we discuss the conclusions…

  9. Optical and Magnetic Resonance Studies of Defects in Iii-V Compound Semiconductors.

    NASA Astrophysics Data System (ADS)

    Sun, Honjiang

    This dissertation describes experimental studies of the basic properties of impurities and defects in III -V compound semiconductors, using a variety of optical and magnetic resonance techniques. The materials used include InP, GaP, and the Al-GaAs alloy. The methods of investigation include absorption, PL, laser spectroscopy, polarization, electron-irradiation, MCD, ODMR, and ODENDOR. The ODENDOR technique is used to investigate a phosphorus antisite-related defect in as-grown p-type GaP. The defect has been previously identified as arising from an excited S = 1 state via luminescence at ~ 1.1eV. It is established that the observed ODENDOR transitions arise from the M_{s} = 0 state, causing unusual magnetic field and orientation effects. Analysis to high-order perturbation theory and/or matrix diagonalization is required. Hyperfine interactions with the central P and several shells of both P and Ga neighbors are observed confirming that the defect has a P_{Ga}-Y_ {p} structure and that the electronic wave function is highly localized. Two antisite structures in InP have been observed and identified using ODENDOR investigation. One of these is the isolated P_{In} antisite previously studied in as-grown and electron-irradiated p-type InP. Another is the perturbed one observed only in electron-irradiated InP. The energy position of the P_sp{In}{+}/P_sp {In}{++}<=vel of the isolated antisite is estimated to be E_{V} + 1.1 +/- 0.05 eV and that of the P_sp{In}{0}/P _sp{In}{+}<=vel is estimated to be E_{V} + 1.39 +/- 0.01 eV. The dependence of the ODENDOR signals of the perturbed antisite on irradiation dose, detection wavelength, and illumination suggests that at least two slightly different such defects are present after the electron irradiation. Our results indicate that the defects are produced by the electron irradiation and are not initially present in the as-grown materials. In as-grown n-type InP:Sn, a broad (Delta B = 360G), structureless, and isotropic g = 1

  10. Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial

    PubMed Central

    Katayama, Kanako; Misawa, Sonoko; Sato, Yasunori; Sobue, Gen; Yabe, Ichiro; Watanabe, Osamu; Nishizawa, Masatoyo; Kusunoki, Susumu; Kikuchi, Seiji; Nakashima, Ichiro; Ikeda, Shu-ichi; Kohara, Nobuo; Kanda, Takashi; Kira, Jun-ichi; Hanaoka, Hideki; Kuwabara, Satoshi

    2015-01-01

    Introduction Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a fatal systemic disorder associated with plasma cell dyscrasia and the overproduction of the vascular endothelial growth factor (VEGF). Recently, the prognosis of POEMS was substantially improved by introduction of therapeutic intervention for myeloma. However, no randomised clinical trial has been performed because of the rarity and severity of the disease. Methods and analysis The Japanese POEMS syndrome with Thalidomide (J-POST) Trial is a phase II/III multicentre, double-blinded, randomised, controlled trial that aims to evaluate the efficacy and safety of a 24-week treatment with thalidomide in POEMS syndrome, with an additional 48-week open-label safety study. Adults with POEMS syndrome who have no indication for transplantation are assessed for eligibility at 12 tertiary neurology centres in Japan. Patients who satisfy the eligibility criteria are randomised (1:1) to receive thalidomide (100–300 mg daily) plus dexamethasone (12 mg/m2 on days 1–4 of a 28-day cycle) or placebo plus dexamethasone. Both treatments were administered for 24 weeks (six cycles; randomised comparative study period). Patients who complete the randomised study period or show subacute deterioration during the randomised period participate in the subsequent 48-week open-label safety study (long-term safety period). The primary end point of the study is the reduction rate of serum VEGF levels at 24 weeks. Ethics and dissemination The protocol was approved by the Institutional Review Board of each hospital. The trial was notified and registered at the Pharmaceutical and Medical Devices Agency, Japan (No. 22-1716). The J-POST Trial is currently ongoing and is due to finish in August 2015. The findings of this trial will be disseminated through peer-reviewed publications and conference presentations and will also be disseminated to participants. Trial registration number

  11. How Did They Get Here, and Why Do They Stay? A Phenomenological Study of Female Athletics Directors at Selected NCAA Division III Member Institutions

    ERIC Educational Resources Information Center

    Parrott, Molly Elizabeth

    2010-01-01

    This qualitative study focused on the educational, professional, and personal experiences of seven women who currently serve as NCAA Division III athletics directors. While previous literature has examined the experiences of women in Divisions I and II, very little has focused specifically on those in Division III, even though more women serve as…

  12. A Study of Title III Projects, Elementary and Secondary Education Act of 1965 (P.L. 83-531) (89-10), after the Approved Funding Periods.

    ERIC Educational Resources Information Center

    Polemeni, Anthony John

    To determine the continuation rate of Title III projects after termination of Federal funding in December 1967, questionnaire response data from directors of 149 projects were analyzed, and a study was made of the respective project proposals on file at the Title III bureau of USOE. For purposes of analysis, projects were categorized by…

  13. Human life support during interplanetary travel and domicile. III - Mars expedition system trade study

    NASA Technical Reports Server (NTRS)

    Seshan, P. K.; Ferrall, Joseph F.; Rohatgi, Naresh K.

    1991-01-01

    Several alternative configurations of life-support systems (LSSs) for a Mars missions are compared analytically on a quantitative basis in terms of weight, volume, and power. A baseline technology set is utilized for the illustrations of systems including totally open loop, carbon dioxide removal only, partially closed loop, and totally closed loop. The analytical model takes advantage of a modular, top-down hierarchical breakdown of LSS subsystems into functional elements that represent individual processing technologies. The open-loop systems are not competitive in terms of weight for both long-duration orbiters and short-duration lander vehicles, and power demands are lowest with the open loop and highest with the closed loop. The closed-loop system can reduce vehicle weight by over 70,000 lbs and thereby overcome the power penalty of 1600 W; the closed-loop variety is championed as the preferred system for a Mars expedition.

  14. Open access and openly accessible: a study of scientific publications shared via the internet

    PubMed Central

    Wren, Jonathan D

    2005-01-01

    Objectives To determine how often reprints of scientific publications are shared online, whether journal readership level is a predictor, how the amount of file sharing changes with the age of the article, and to what degree open access publications are shared on non-journal websites. Design The internet was searched using an application programming interface to Google, a popular and freely available search engine. Main outcome measures The proportion of reprints of journal articles published between 1994 and 2004 from within 13 subscription based and four open access journals that could be located online at non-journal websites. Results The probability that an article could be found online at a non-journal website correlated with the journal impact factor and the time since initial publication. Papers from higher impact journals and more recent articles were more likely to be located. On average, for the high impact journal articles published in 2003, over a third could be located at non-journal websites. Similar trends were observed for the delayed or full open access publications. Conclusions Decentralised sharing of scientific reprints through the internet creates a degree of de facto open access that, though highly incomplete in its coverage, is none the less biased towards publications of higher popular demand. PMID:15827063

  15. Open market customer: Volume 2 -- Case study assessments. Final report

    SciTech Connect

    Kotowski, J.; Wikler, G.; Milward, R.; Gudger, K.

    1998-06-01

    This second volume of the Open Market Customer (OMC) contains the case study assessments that illustrate the discussions in Volume 1 and the supporting framework. There are two types of assessments in this volume: actual case studies and prototype case studies. The first, the actual case studies are full OMC assessments of four different types of existing large commercial/industrial facilities. They are, in order of their appearance in this volume: Logan International Airport, Boston, MA--Airport; Washington University, St. Louis, MO--Four-Year University; Cook County Hospital, Chicago, IL--Hospital; and Sierra Pine Ltd., Rocklin, CA--Wood Products Manufacturing. The second type of assessments are the prototype case studies. They were performed on four different types of facilities falling under two market segments. These facilities` models were developed using assumed characteristics, such as floor areas and energy sources. They are, in order of appearance in this volume: Retail Building--small commercial; Sit-Down Restaurant--small commercial; Primary School--small commercial; and Planned Residential Community--residential. For each facility, the characteristics or assumptions are described in detail. Using these characteristics or assumptions a framework for each energy type used on-site was developed. Each framework describes the annual consumption of that energy type as well as the infrastructure supporting it. For example, a facility`s electricity framework shows the estimated annual electricity consumption and expenditures within each of the nine functional areas at that facility. Further, the framework shows the estimated capital associated with each functional area, such as substations, electric distribution lines, and motors. Appendices at the end of this volume contain the frameworks for each case study.

  16. The efficacy of recombinant human activated protein C (rhAPC) vs antithrombin III (at III) vs heparin, in the healing process of partial-thickness burns: a comparative study

    PubMed Central

    Kritikos, O.; Tsagarakis, M.; Tsoutsos, D.; Kittas, C.; Gorgoulis, V.; Papalois, A.; Giannopoulos, A.; Kakiopoulos, G.; Papadopoulos, O.

    2012-01-01

    Summary This is an experimental study regarding the positive effect of recombinant human activated protein C (rhAPC) in the healing process of partial-thickness burns, in comparison to antithrombin III and heparin. On a porcine model we induced superficial partial-thickness and deep partial-thickness burns and performed intravenous administration of the elements of study during the first 48 h. The progress of the condition of the injured tissues was evaluated by histopathological examination at specific time intervals. The results showed an improved healing response of the specimens treated with rhAPC compared to those treated with antithrombin III, heparin, and placebo. PMID:23233823

  17. Multispectroscopic DNA-binding studies of a terbium(III) complex containing 2,2'-bipyridine ligand.

    PubMed

    Aramesh-Boroujeni, Zahra; Khorasani-Motlagh, Mozhgan; Noroozifar, Meissam

    2016-01-01

    Agarose gel electrophoresis, absorption, fluorescence, viscosity, and circular dichroism (CD) have been used in exploring the interaction of terbium(III) complex, [Tb(bpy)2Cl3(OH2)] where bipy is 2,2'-bipyridine, with Fish salmon DNA. Agarose gel electrophoresis assay, along with absorption and fluorescence studies, reveal interaction between the corresponding complex and FS-DNA. Also, the binding constants (Kb) and the Stern-Volmer quenching constants (Ksv) of Tb(III) complex with FS-DNA were determined. The calculated thermodynamic parameters suggested that the binding of mentioned complex to FS-DNA was driven mainly by hydrophobic interactions. A comparative study of this complex with respect to the effect of iodide-induced quenching, ionic strength effect, and ethidium bromide exclusion assay reflects binding of explicit to the FS-DNA primarily in a groove fashion. CD and viscosity data also support the groove binding mode. Furthermore, Tb(III) complex have been simultaneously screened for their antibacterial and antifungal activities.

  18. An open multicenter comparative randomized clinical study on chitosan.

    PubMed

    Mo, Xiaohui; Cen, John; Gibson, Elaine; Wang, Robin; Percival, Steven L

    2015-01-01

    Chitosan, a natural polysaccharide derivate from chitin, offers a promising alternative biomaterial for use in wound dressings. In this work, the safety and efficacy of a next-generation KA01 chitosan wound dressing in facilitating the healing of nonhealing chronic wounds was studied. This open multicenter comparative prospective randomized clinical study was conducted at three medical centers in China. A total of 90 patients (45 in test group and 45 in control group) with unhealed chronic wounds including pressure ulcers, vascular ulcers, diabetic foot ulcers, and wounds with minor infections, or at risk of infection, were treated with the next generation chitosan wound dressing as the test article or traditional vaseline gauze as a control. Baseline assessments were undertaken with the primary end point being wound area reduction. The secondary end points included pain reduction (using the NRS11 pain scale) at dressing change, wound exudate levels, wound depth and duration of the treatment. After 4 weeks treatment, the wound area reduction was significantly greater in the test group (65.97 ± 4.48%) than the control group (39.95 ± 4.48%). The average pain level in the test group was 1.12 ± 0.23 and 2.30 ± 0.23 in the control group. The wound depth was also lower in the test group 0.30 ± 0.48 cm than the control group 0.54 ± 0.86 cm. The level of exudate fell and the dressing could be removed integrally in both the test and control groups. The mean duration of the test group was 27.31 ± 5.37 days and control group 27.09 ± 6.44 days. No adverse events were reported in either group. In conclusion this open multicenter comparative prospective randomized clinical study has provided compelling evidence that the next generation chitosan wound dressing can enhance wound progression towards healing by facilitating wound reepithelialization and reducing the patients pain level. Furthermore the dressing was shown to be clinically safe and effective in the management

  19. An open multicenter comparative randomized clinical study on chitosan.

    PubMed

    Mo, Xiaohui; Cen, John; Gibson, Elaine; Wang, Robin; Percival, Steven L

    2015-01-01

    Chitosan, a natural polysaccharide derivate from chitin, offers a promising alternative biomaterial for use in wound dressings. In this work, the safety and efficacy of a next-generation KA01 chitosan wound dressing in facilitating the healing of nonhealing chronic wounds was studied. This open multicenter comparative prospective randomized clinical study was conducted at three medical centers in China. A total of 90 patients (45 in test group and 45 in control group) with unhealed chronic wounds including pressure ulcers, vascular ulcers, diabetic foot ulcers, and wounds with minor infections, or at risk of infection, were treated with the next generation chitosan wound dressing as the test article or traditional vaseline gauze as a control. Baseline assessments were undertaken with the primary end point being wound area reduction. The secondary end points included pain reduction (using the NRS11 pain scale) at dressing change, wound exudate levels, wound depth and duration of the treatment. After 4 weeks treatment, the wound area reduction was significantly greater in the test group (65.97 ± 4.48%) than the control group (39.95 ± 4.48%). The average pain level in the test group was 1.12 ± 0.23 and 2.30 ± 0.23 in the control group. The wound depth was also lower in the test group 0.30 ± 0.48 cm than the control group 0.54 ± 0.86 cm. The level of exudate fell and the dressing could be removed integrally in both the test and control groups. The mean duration of the test group was 27.31 ± 5.37 days and control group 27.09 ± 6.44 days. No adverse events were reported in either group. In conclusion this open multicenter comparative prospective randomized clinical study has provided compelling evidence that the next generation chitosan wound dressing can enhance wound progression towards healing by facilitating wound reepithelialization and reducing the patients pain level. Furthermore the dressing was shown to be clinically safe and effective in the management

  20. Crystal structure of K0.75[FeII 3.75FeIII 1.25(HPO3)6]·0.5H2O, an open-framework iron phosphite with mixed-valent FeII/FeIII ions

    PubMed Central

    Larrea, Edurne S.; Mesa, José Luis; Legarra, Estibaliz; Aguayo, Andrés Tomás; Arriortua, Maria Isabel

    2016-01-01

    Single crystals of the title compound, potassium hexa­phosphito­penta­ferrate(II,III) hemihydrate, K0.75[FeII 3.75FeIII 1.25(HPO3)6]·0.5H2O, were grown under mild hydro­thermal conditions. The crystal structure is isotypic with Li1.43[FeII 4.43FeIII 0.57(HPO3)6]·1.5H2O and (NH4)2[FeII 5(HPO3)6] and exhibits a [FeII 3.75FeIII 1.25(HPO3)6]0.75− open framework with disordered K+ (occupancy 3/4) as counter-cations. The anionic framework is based on (001) sheets of two [FeO6] octa­hedra (one with point group symmetry 3.. and one with point group symmetry .2.) linked along [001] through [HPO3]2− oxoanions. Each sheet is constructed from 12-membered rings of edge-sharing [FeO6] octa­hedra, giving rise to channels with a radius of ca 3.1 Å where the K+ cations and likewise disordered water mol­ecules (occupancy 1/4) are located. O⋯O contacts between the water mol­ecule and framework O atoms of 2.864 (5) Å indicate hydrogen-bonding inter­actions of medium strength. The infrared spectrum of the compound shows vibrational bands typical for phosphite and water groups. The Mössbauer spectrum is in accordance with the presence of FeII and FeIII ions. PMID:26870587

  1. Numerical study of compressible magnetoconvection with an open transitional boundary

    SciTech Connect

    Hanami, H.; Tajima, T.

    1990-08-01

    We study by computer simulation nonlinear evolution of magnetoconvection in a system with a dynamical open boundary between the convection region and corona of the sun. We study a model in which the fluid is subject to the vertical gravitation, magnetohydrodynamics (MHD), and high stratification, through an MHD code with the MacCormack-Donner cell hybrid scheme in order to well represent convective phenomena. Initially the vertical fluid flux penetrates from the convectively unstable zone at the bottom into the upper diffuse atmosphere. As the instability develops, the magnetic fields are twisted by the convection motion and the folding magnetic fields is observed. When the magnetic pressure is comparable to the thermal pressure in the upper layer of convective zone, strong flux expulsion from the convective cell interior toward the cell boundary appears. Under appropriate conditions our simulation exhibits no shock formation incurred by the fluid convected to the photosphere, in contrast to earlier works with box boundaries. The magnetic field patterns observed are those of concentrated magnetic flux tubes, accumulation of dynamo flux near the bottom boundary, pinched flux near the downdraft region, and the surface movement of magnetic flux toward the downdraft region. Many of these computationally observed features are reminiscent of solar observations of the fluid and magnetic structures of their motions.

  2. Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans.

    PubMed

    Sarre, Aili; Ökvist, Mats; Klar, Tobias; Hall, David R; Smalås, Arne O; McSweeney, Sean; Timmins, Joanna; Moe, Elin

    2015-08-01

    While most bacteria possess a single gene encoding the bifunctional DNA glycosylase Endonuclease III (EndoIII) in their genomes, Deinococcus radiodurans possesses three: DR2438 (DrEndoIII1), DR0289 (DrEndoIII2) and DR0982 (DrEndoIII3). Here we have determined the crystal structures of DrEndoIII1 and an N-terminally truncated form of DrEndoIII3 (DrEndoIII3Δ76). We have also generated a homology model of DrEndoIII2 and measured activity of the three enzymes. All three structures consist of two all α-helical domains, one of which exhibits a [4Fe-4S] cluster and the other a HhH-motif, separated by a DNA binding cleft, similar to previously determined structures of endonuclease III from Escherichia coli and Geobacillus stearothermophilus. However, both DrEndoIII1 and DrEndoIII3 possess an extended HhH motif with extra helical features and an altered electrostatic surface potential. In addition, the DNA binding cleft of DrEndoIII3 seems to be less accessible for DNA interactions, while in DrEndoIII1 it seems to be more open. Analysis of the enzyme activities shows that DrEndoIII2 is most similar to the previously studied enzymes, while DrEndoIII1 seems to be more distant with a weaker activity towards substrate DNA containing either thymine glycol or an abasic site. DrEndoIII3 is the most distantly related enzyme and displays no detectable activity towards these substrates even though the suggested catalytic residues are conserved. Based on a comparative structural analysis, we suggest that the altered surface potential, shape of the substrate-binding pockets and specific amino acid substitutions close to the active site and in the DNA interacting loops may underlie the unexpected differences in activity. PMID:26172070

  3. Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans.

    PubMed

    Sarre, Aili; Ökvist, Mats; Klar, Tobias; Hall, David R; Smalås, Arne O; McSweeney, Sean; Timmins, Joanna; Moe, Elin

    2015-08-01

    While most bacteria possess a single gene encoding the bifunctional DNA glycosylase Endonuclease III (EndoIII) in their genomes, Deinococcus radiodurans possesses three: DR2438 (DrEndoIII1), DR0289 (DrEndoIII2) and DR0982 (DrEndoIII3). Here we have determined the crystal structures of DrEndoIII1 and an N-terminally truncated form of DrEndoIII3 (DrEndoIII3Δ76). We have also generated a homology model of DrEndoIII2 and measured activity of the three enzymes. All three structures consist of two all α-helical domains, one of which exhibits a [4Fe-4S] cluster and the other a HhH-motif, separated by a DNA binding cleft, similar to previously determined structures of endonuclease III from Escherichia coli and Geobacillus stearothermophilus. However, both DrEndoIII1 and DrEndoIII3 possess an extended HhH motif with extra helical features and an altered electrostatic surface potential. In addition, the DNA binding cleft of DrEndoIII3 seems to be less accessible for DNA interactions, while in DrEndoIII1 it seems to be more open. Analysis of the enzyme activities shows that DrEndoIII2 is most similar to the previously studied enzymes, while DrEndoIII1 seems to be more distant with a weaker activity towards substrate DNA containing either thymine glycol or an abasic site. DrEndoIII3 is the most distantly related enzyme and displays no detectable activity towards these substrates even though the suggested catalytic residues are conserved. Based on a comparative structural analysis, we suggest that the altered surface potential, shape of the substrate-binding pockets and specific amino acid substitutions close to the active site and in the DNA interacting loops may underlie the unexpected differences in activity.

  4. Fundamental Studies and Development of III-N Visible LEDs for High-Power Solid-State Lighting Applications

    SciTech Connect

    Dupuis, Russell

    2012-02-29

    The goal of this program is to understand in a fundamental way the impact of strain, defects, polarization, and Stokes loss in relation to unique device structures upon the internal quantum efficiency (IQE) and efficiency droop (ED) of III-nitride (III-N) light-emitting diodes (LEDs) and to employ this understanding in the design and growth of high-efficiency LEDs capable of highly-reliable, high-current, high-power operation. This knowledge will be the basis for our advanced device epitaxial designs that lead to improved device performance. The primary approach we will employ is to exploit new scientific and engineering knowledge generated through the application of a set of unique advanced growth and characterization tools to develop new concepts in strain-, polarization-, and carrier dynamics-engineered and low-defect materials and device designs having reduced dislocations and improved carrier collection followed by efficient photon generation. We studied the effects of crystalline defect, polarizations, hole transport, electron-spillover, electron blocking layer, underlying layer below the multiplequantum- well active region, and developed high-efficiency and efficiency-droop-mitigated blue LEDs with a new LED epitaxial structures. We believe new LEDs developed in this program will make a breakthrough in the development of high-efficiency high-power visible III-N LEDs from violet to green spectral region.

  5. Bone thickness of the infrazygomatic crest area in skeletal Class III growing patients: A computed tomographic study

    PubMed Central

    Lee, Hyub-Soo; Choi, Hang-Moon; Choi, Dong-Soon; Jang, Insan

    2013-01-01

    Purpose This study was performed to investigate the bone thickness of the infrazygomatic crest area by computed tomography (CT) for placement of a miniplate as skeletal anchorage for maxillary protraction in skeletal Class III children. Materials and Methods CT images of skeletal Class III children (7 boys, 9 girls, mean age: 11.4 years) were taken parallel to the Frankfurt horizontal plane. The bone thickness of the infrazygomatic crest area was measured at 35 locations on the right and left sides, perpendicular to the bone surface. Results The bone was thickest (5.0 mm) in the upper zygomatic bone and thinnest (1.1 mm) in the anterior wall of the maxillary sinus. Generally, there was a tendency for the bone to be thicker at the superior and lateral area of the zygomatic process of the maxilla. There was no clinically significant difference in bone thickness between the right and left sides; however, it was thicker in male than in female subjects. Conclusion In the infrazygomatic crest area, the superior and lateral area of the zygomatic process of the maxilla had the most appropriate thickness for placement of a miniplate in growing skeletal Class III children with a retruded maxilla. PMID:24380065

  6. A comparative study on the binding of single and double chain surfactant-cobalt(III) complexes with bovine serum albumin.

    PubMed

    Vignesh, G; Sugumar, K; Arunachalam, S; Vignesh, S; Arthur James, R

    2013-09-01

    The comparative binding effect of single and double aliphatic chain containing surfactant-cobalt(III) complexes cis-[Co(bpy)2(DA)2](ClO4)3·2H2O (1), cis-[Co(bpy)2(DA)Cl](ClO4)2·2H2O (2), cis-[Co(phen)2(CA)2](ClO4)3·2H2O (3), and cis-[Co(phen)2(CA)Cl](ClO4)2·2H2O (4) with bovine serum albumin (BSA) under physiological condition was analyzed by steady state, time resolved fluorescence, synchronous, three-dimensional fluorescence, UV-Visible absorption and circular dichroism spectroscopic techniques. The results show that these complexes cause the fluorescence quenching of BSA through a static mechanism. The binding constants (Kb) and the number of binding sites were calculated and binding constant values are found in the range of 10(4)-10(5) M(-1). The results indicate that compared to single chain complex, double chain surfactant-cobalt(III) complex interacts strongly with BSA. Also the sign of thermodynamic parameters (ΔG°, ΔH°, and ΔS°) indicate that all the complexes interact with BSA through hydrophobic force. The binding distance (r) between complexes and BSA was calculated using Förster non-radiation energy transfer theory and found to be less than 7 nm. The results of synchronous, three dimensional fluorescence and circular dichroism spectroscopic methods indicate that the double chain surfactant-cobalt(III) complexes changed the conformation of the protein considerably than the respective single chain surfactant-cobalt(III) complexes. Antimicrobial studies of the complexes showed good activities against pathogenic microorganisms.

  7. A comparative study on the binding of single and double chain surfactant-cobalt(III) complexes with bovine serum albumin.

    PubMed

    Vignesh, G; Sugumar, K; Arunachalam, S; Vignesh, S; Arthur James, R

    2013-09-01

    The comparative binding effect of single and double aliphatic chain containing surfactant-cobalt(III) complexes cis-[Co(bpy)2(DA)2](ClO4)3·2H2O (1), cis-[Co(bpy)2(DA)Cl](ClO4)2·2H2O (2), cis-[Co(phen)2(CA)2](ClO4)3·2H2O (3), and cis-[Co(phen)2(CA)Cl](ClO4)2·2H2O (4) with bovine serum albumin (BSA) under physiological condition was analyzed by steady state, time resolved fluorescence, synchronous, three-dimensional fluorescence, UV-Visible absorption and circular dichroism spectroscopic techniques. The results show that these complexes cause the fluorescence quenching of BSA through a static mechanism. The binding constants (Kb) and the number of binding sites were calculated and binding constant values are found in the range of 10(4)-10(5) M(-1). The results indicate that compared to single chain complex, double chain surfactant-cobalt(III) complex interacts strongly with BSA. Also the sign of thermodynamic parameters (ΔG°, ΔH°, and ΔS°) indicate that all the complexes interact with BSA through hydrophobic force. The binding distance (r) between complexes and BSA was calculated using Förster non-radiation energy transfer theory and found to be less than 7 nm. The results of synchronous, three dimensional fluorescence and circular dichroism spectroscopic methods indicate that the double chain surfactant-cobalt(III) complexes changed the conformation of the protein considerably than the respective single chain surfactant-cobalt(III) complexes. Antimicrobial studies of the complexes showed good activities against pathogenic microorganisms. PMID:23747382

  8. Ab initio studies on the structure of and atomic interactions in cellulose III(I) crystals.

    PubMed

    Ishikawa, Tetsuya; Hayakawa, Daichi; Miyamoto, Hitomi; Ozawa, Motoyasu; Ozawa, Tomonaga; Ueda, Kazuyoshi

    2015-11-19

    The crystal structure of cellulose III(I)was analyzed using first-principles density functional theory (DFT). The geometry was optimized using variable-cell relaxation, as implemented in Quantum ESPRESSO. The Perdew-Burke-Ernzerhof (PBE) functional with a correction term for long-range van der Waals interactions (PBE-D) reproduced the experimental structure well. By using the optimized crystal structure, the interactions existed among the cellulose chains in the crystal were precisely investigated using the NBO analysis. The results showed that the weak bonding nature of CH/O and the hydrogen bonding occur among glucose molecules in the optimized crystal structure. To investigate the strength of interaction, dimeric and trimeric glucose units were extracted from the crystal, and analyzed using MP2 ab initio counterpoise methods with BSSE correction. The results estimated the strength of the interactions. That is, the packed chains along with a-axis interacts with weak bonding nature of CH/O and dispersion interactions by -7.50 kcal/mol, and two hydrogen bonds of O2HO2…O6 and O6HO6…O2 connect the neighboring packed chains with -11.9 kcal/mol. Moreover, FMO4 calculation was also applied to the optimized crystal structure to estimate the strength of the interactions. These methods can well estimate the interactions existed in the crystal structure of cellulose III(I).

  9. WIYN Open Cluster Study: UBVRI Photometry of NGC 2158

    NASA Astrophysics Data System (ADS)

    Taverne, Luke T.; Steinhauer, Aaron J.; Deliyannis, Constantine P.

    2015-01-01

    We present WIYN 0.9m HDI UBVRI photometry of NGC 2158, a very rich, intermediate-aged, open cluster located near the galactic anti-center. We report derived values for the cluster age, distance, reddening.

  10. Optical polarization study towards the open cluster NGC 6249

    NASA Astrophysics Data System (ADS)

    Vergne, M. M.; Orsatti, A. M.; Feinstein, C.; Vega, E. I.; Martínez, R. E.

    2016-04-01

    We present multicolor linear polarimetric data (UBVRI) of 30 of the brightest stars in the region of the open cluster NGC 6249. The cluster members were found to be part of two subgroups with average polarization and orientation of the electric vector of P_{V}=1.7% ± 0.13, θ_{V}=39.7° ± 2.2; and P_{V}=2.34% ± 0.07, θ_{V}=41.0° ± 1.2, respectively. This difference in polarization may be a consequence of the presence of a dark, U-shaped absorbing zone seen on the central region, and probably located in front of, or inside, the cluster. From the study of the evolution of the A_v with the distance,we found evidence of the existence of two layers of dust at distances of ≈ 250 pc and ≈ 600 pc. The comparison between the polarimetric parameters of NGC 6249 and those of the nearby cluster NGC 6250 showed some coincidences.

  11. A phase III, randomized, non-inferiority study comparing the efficacy and safety of biosimilar filgrastim versus originator filgrastim for chemotherapy-induced neutropenia in breast cancer patients

    PubMed Central

    Hegg, Roberto; Mattar, André; de Matos, João Nunes; Pedrini, José Luiz; Aleixo, Sabina Bandeira; Rocha, Roberto Odebrecht; Cramer, Renato Peixoto; van-Eyll-Rocha, Sylvie

    2016-01-01

    OBJECTIVES: To compare the efficacy and safety of two filgrastim formulations for controlling chemotherapy-induced neutropenia and to evaluate the non-inferiority of the test drug relative to the originator. METHODS: This phase III non-inferiority study had a randomized, multicenter, and open-label design. The patients were randomized at a ratio of 1:1 with a follow-up period of 6 weeks for each patient. In both study arms, filgrastim was administered subcutaneously at a daily dose of 5 mg/kg body weight. The primary endpoint was the rate of grade 4 neutropenia in the first treatment cycle. The secondary endpoints were the duration of grade 4 neutropenia, the generation of anti-filgrastim antibodies, and the rates of adverse events, laboratory abnormalities, febrile neutropenia, and neutropenia of any grade. RESULTS: The primary efficacy analysis demonstrated the non-inferiority of the test drug compared with the originator drug; the upper limit of the 90% confidence interval (CI) for the rate of neutropenia between the two groups (12.61%) was lower than the established margin of non-inferiority. The two treatments were similar with respect to the secondary endpoints and safety. CONCLUSION: The efficacy and safety profile of the test drug were similar to those of the originator product based on the rate of grade 4 neutropenia in the first treatment cycle. This study supports Anvisa's approval of the first biosimilar drug manufactured by the Brazilian industry (Fiprima®). PMID:27759847

  12. Binding Studies of a New Water-Soluble Iron(III) Schiff Base Complex to DNA Using Multispectroscopic Methods

    PubMed Central

    Shahabadi, Nahid; Ghasemian, Zeinab; Hadidi, Saba

    2012-01-01

    A novel iron(III) complex [Fe(SF)](ClO4)3.2H2O; in which SF = N,N0-bis{5-[(triphenylphosphonium chloride)-methyl] salicylidene}-o-phenylenediamine) has been synthesized and characterized using different physicochemical methods. The binding of this complex with calf thymus (CT) DNA was investigated by circular dichroism, absorption studies, emission spectroscopy, voltammetric studies, and viscosity measurements. The results showed that this complex can bind to DNA via external and groove binding modes. PMID:22899896

  13. A spectrophotometric study of aqueous Au(III) halide-hydroxide complexes at 25-80 °C

    NASA Astrophysics Data System (ADS)

    Usher, Al; McPhail, D. C.; Brugger, Joël

    2009-06-01

    The mobility and transport of gold in low-temperature waters and brines is affected by the aqueous speciation of gold, which is sensitive in particular to pH, oxidation and halide concentrations. In this study, we use UV-Vis spectrophotometry to identify and measure the thermodynamic properties of Au(III) aqueous complexes with chloride, bromide and hydroxide. Au(III) forms stable square planar complexes with hydroxide and halide ligands. Based on systematic changes in the absorption spectra of solutions in three binary systems NaCl-NaBr, NaCl-NaOH and NaBr-NaOH at 25 °C, we derived log dissociation constants for the following mixed and end-member halide and hydroxide complexes: [AuCl 3Br] -, [AuCl 2Br 2] -, [AuBr 3Cl] - and [AuBr 4] -; [AuCl 3(OH)] -, [AuCl 2(OH) 2] -, [AuCl(OH) 3] - and [Au(OH) 4] -; and [AuBr 3(OH)] -, [AuBr 2(OH) 2] - and [AuBr(OH) 3] -. These are the first reported results for the mixed chloride-bromide complexes. Increasing temperature to 80 °C resulted in an increase in the stability of the mixed chloride-bromide complexes, relative to the end-member chloride and bromide complexes. For the [AuCl (4-n)(OH) n] - series of complexes ( n = 0-4), there is an excellent agreement between our spectrophotometric results and previous electrochemical results of Chateau et al. [Chateau et al. (1966)]. In other experiments, the iodide ion (I -) was found to be unstable in the presence of Au(III), oxidizing rapidly to I 2(g) and causing Au to precipitate. Predicted Au(III) speciation indicates that Au(III) chloride-bromide complexes can be important in transporting gold in brines with high bromide-chloride ratios (e.g., >0.05), under oxidizing (atmospheric), acidic (pH < 5) conditions. Native gold solubility under atmospheric oxygen conditions is predicted to increase with decreasing pH in acidic conditions, increasing pH in alkaline conditions, increasing chloride, especially at acid pH, and increasing bromide for bromide/chloride ratios greater than 0

  14. Intravenous pamidronate versus oral and intravenous clodronate in bone metastatic breast cancer: a randomized, open-label, non-inferiority Phase III trial

    PubMed Central

    von Au, Alexandra; Milloth, Eva; Diel, Ingo; Stefanovic, Stefan; Hennigs, Andre; Wallwiener, Markus; Heil, Joerg; Golatta, Michael; Rom, Joachim; Sohn, Christof; Schneeweiss, Andreas; Schuetz, Florian; Domschke, Christoph

    2016-01-01

    Purpose Patients with metastasized breast cancer often suffer from discomfort caused by metastatic bone disease. Thus, osteoprotection is an important part of therapy in breast cancer metastasized to bone, and bisphosphonates (BPs) are a major therapeutic option. In this study, our objectives were to compare the side effects of oral versus intravenous BP treatment and to assess their clinical effectiveness. Patients and methods In this prospective randomized, open-label, non-inferiority trial, we enrolled breast cancer patients with at least one bone metastasis and an Eastern Cooperative Oncology Group performance status of 0–2. Patients were randomly assigned to one of the three treatment groups: A, 60 mg pamidronate intravenously q3w; B-iv, 900 mg clodronate intravenously q3w; and B-o, 2,400 mg oral clodronate daily. Assessments were performed at baseline and every 3 months thereafter. Results Between 1995 and 1999, 321 patients with confirmed bone metastases from breast cancer were included in the study. At first follow-up, gastrointestinal (GI) tract side effects were most common, and adverse effects on the GI tract were more frequent in the oral treatment group (P=0.002 and P<0.001, respectively). There were no statistically significant differences among the treatment cohorts for other documented side effects (skin, serum electrolytes, urinary tract, immune system, and others). No significant differences in clinical effectiveness of BP treatment, as assessed by pain score, were detected among the groups; however, pathologic fractures were more effectively prevented by intravenous than oral BP administration (P=0.03). Noncompliance rates were similar among the study cohorts. Conclusion We conclude that oral BP treatment is significantly associated with higher rates of adverse GI side effects. Additionally, our data indicate that intravenous BP administration is more effective than oral treatment in prevention of pathologic fractures; hence, oral

  15. Rotigotine transdermal system for long-term treatment of patients with advanced Parkinson's disease: results of two open-label extension studies, CLEOPATRA-PD and PREFER.

    PubMed

    LeWitt, Peter A; Boroojerdi, Babak; Surmann, Erwin; Poewe, Werner

    2013-07-01

    Open-label extensions [studies SP516 (NCT00501969) and SP715 (NCT00594386)] of the CLEOPATRA-PD and PREFER studies were conducted to evaluate the safety, tolerability and efficacy of the dopaminergic agonist, rotigotine, over several years of follow-up in patients with advanced Parkinson's disease (PD). Eligible subjects completing the double-blind trials received open-label adjunctive rotigotine (≤16 mg/24 h) for up to 4 and 6 years in Studies SP516 and SP715, respectively. Safety and tolerability were assessed using adverse events, vital signs and laboratory parameters, and efficacy assessed using the unified Parkinson's disease rating scale (UPDRS). Of the 395 and 258 patients enrolled in the SP516 and SP715 studies, 48 and 45 % completed, respectively. Adverse events were typically dopaminergic effects [e.g., somnolence (18-25 %/patient-year), insomnia (5-7 %/patient-year), dyskinesias (4-8 %/patient-year) and hallucinations (4-8 %/patient-year)], or related to the transdermal application of a patch (application site reactions: 14-15 %/patient-year). There were no clinically relevant changes in vital signs or laboratory parameters in either study. Mean UPDRS part II (activities of daily living) and part III (motor function) total scores improved from double-blind baseline during dose titration, then gradually declined over the maintenance period. In study SP516, mean UPDRS part II and III total scores were 0.8 points above and 2.8 points below double-blind baseline, respectively, at end of treatment. In study SP715, mean UPDRS part II and III total scores were 4.1 points above and 0.2 points below baseline, respectively, at end of treatment. In these open-label studies, adjunctive rotigotine was efficacious with an acceptable safety and tolerability profile in patients with advanced PD for up to 6 years.

  16. A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease

    PubMed Central

    Sibley, Cailin H; Chioato, Andrea; Felix, Sandra; Colin, Laurence; Chakraborty, Abhijit; Plass, Nikki; Rodriguez-Smith, Jackeline; Brewer, Carmen; King, Kelly; Zalewski, Christopher; Kim, H Jeffrey; Bishop, Rachel; Abrams, Ken; Stone, Deborah; Chapelle, Dawn; Kost, Bahar; Snyder, Christopher; Butman, John A; Wesley, Robert; Goldbach-Mansky, Raphaela

    2014-01-01

    Objective To study efficacy and safety of escalating doses of canakinumab, a fully human anti-IL-1β monoclonal antibody in the severe cryopyrin-associated periodic syndrome, neonatal-onset multisystem inflammatory disease (NOMID). Methods 6 patients were enrolled in this 24-month, open-label phase I/II study. All underwent anakinra withdrawal. The initial subcutaneous canakinumab dose was 150 mg (or 2 mg/kg in patients ≤40 kg) or 300 mg (or 4 mg/kg) with escalation up to 600 mg (or 8 mg/kg) every 4 weeks. Full remission was remission of patientreported clinical components and measures of systemic inflammation and CNS inflammation. Hearing, vision and safety were assessed. Primary endpoint was full remission at month 6. Results All patients flared after anakinra withdrawal, and symptoms and serum inflammatory markers improved with canakinumab. All patients required dose escalation to the maximum dose. At month 6, none had full remission, although 4/6 achieved inflammatory remission, based on disease activity diary scores and normal C-reactive proteins. None had CNS remission; 5/6 due to persistent CNS leucocytosis. At the last study visit, 5/6 patients achieved inflammatory remission and 4/6 had continued CNS leucocytosis. Visual acuity and field were stable in all patients, progressive hearing loss occurred in 1/10 ears. Adverse events (AEs) were rare. One serious AE (abscess due to a methicillin-resistant Staphylococcus aureus infection) occurred. Conclusions Canakinumab at the studied doses improves symptoms and serum inflammatory features of NOMID, although low-grade CNS leukocytosis in four patients and headaches in one additional patient persisted. Whether further dose intensifications are beneficial in these cases remains to be assessed. ClinicalTrials.gov identifier NCT00770601. PMID:24906637

  17. The construction of open Gd(III) metal-organic frameworks based on methanetriacetic acid: new objects with an old ligand.

    PubMed

    Cañadillas-Delgado, Laura; Martín, Tomás; Fabelo, Oscar; Pasán, Jorge; Delgado, Fernando S; Lloret, Francesc; Julve, Miguel; Ruiz-Pérez, Catalina

    2010-04-01

    The preparation, X-ray crystallography and magnetic investigation of the first examples of methanetriacetate (mta)-containing lanthanide(III) complexes of formulae [Gd(mta)(H(2)O)(3)](n)4 n H(2)O (1) [Gd(mta)(H(2)O)(3)](n)2 n H(2)O (2) and [Gd(2)(mta)(2)(H(2)O)(2)](n)2 n H(2)O (3) are described herein. This tripodal ligand promotes the formation of 6(3) networks; thus 1 consists of a honeycomb structure, whereas in 2 two of these layers are condensed to form a rare five-connected two-dimensional (4(8)6(2)) network. Compound 3 can be seen as an aggregation of 6(3) layers leading to a three-dimensional (6,6)-connected binodal (4(12)6(3))(4(9)6(6))-nia net, in which the gadolinium(III) ions and the mta ligands act as octahedral and as trigonal prismatic nodes, respectively. The magnetic properties of 1-3 were investigated in the temperature range 1.9-300 K. A close fit to the Curie law (1) and weak either antiferro- [J=-0.0063(1) cm(-1) (2)] or ferromagnetic [J=+0.0264(6) cm(-1) (3)] interactions between the Gd(III) ions are observed; the different exchange pathways involved [extended tris-bidentate mta (1) and mu-O(1);kappa(2)O(1),O(2) (2 and 3) plus single syn-syn carboxylate-mta (3)] accounting for these magnetic features. The nature and magnitude of the magnetic interactions, between the Gd(III) ions in 1-3, agree with the small amount of data existing in the literature for these kind of bridges.

  18. Structural studies of the antigen III cell wall polysaccharide of Trichosporon domesticum.

    PubMed

    Ichikawa, T; Nishikawa, A; Wada, H; Ikeda, R; Shinoda, T

    2001-02-28

    Cell wall and soluble polysaccharides that reacted with Trichosporon domesticum factor III serum were isolated from the type strain of T. domesticum. The fractions contained O-acetyl groups, which contributed to the serological reactivity. The antigenic structure was characterized by chromatographic and spectroscopic methods. The polysaccharide has an alpha-(1-->3)-D-mannan backbone with hetero-oligosaccharide side chains consisting of a 2-O-substituted beta-D-glucuronic acid residue bound to O-2 of the mannose residue, beta-D-xylopyranosyl residues located in the middle of the side chain, and a nonreducing terminal alpha-L-arabinopyranosyl residue bound to 0-4 of xylose. The mannan backbone is O-acetylated at O-6 of the mannose residues.

  19. Studies on the complexation of Pr(III) and Nd(III) with glycyl-glycine (gly-gly) using spectral analysis of 4f-4f transitions and potentiometric titrations.

    PubMed

    Ranjana Devi, N; Huidrom, Bimola; Rajmuhon Singh, N

    2012-10-01

    The interaction of gly-gly with Pr(III) and Nd(III) have been studied in different aquated organic solvents like CH(3)OH, CH(3)CN, dioxane and DMF by using 4f-4f transitions spectra. Various energy interaction parameters like Slater Condon (F(k)), Racah (E(k)), Lande (ξ(4f)), nephelauxetic effect (β), bonding (b(1/2)) and percent covalency (δ) parameters have been calculated to explain the nature of complexation. The intensity parameters like oscillator strength (P) and Judd-Ofelt parameters (T(λ), λ=2, 4, 6) also support the mode of binding of gly-gly to metal ions. The results show that Pr(III) and Nd(III) with gly-gly form complexes by ionic linkages with carboxylate anion with weak covalency. The protonation constants and metal-ligand stability constants have also been determined by potentiometric measurements in aqueous medium at different temperatures (290, 300 and 310 K) at constant ionic strength, 0.1 mol dm(-1). The results show the formation of metal-ligand complexes in the stoichiometric ratio 1:1. The stability of complexes is more in Nd(III) complexes as compared to Pr(III) complexes. Thermodynamic parameters (ΔG, ΔH and ΔS) of complexes were also calculated and the negative values of ΔG and ΔH show that the complex reactions are spontaneous and exothermic. The positive values of ΔS indicate high stability of complex reactions which are enthalpy-driven.

  20. Studies on the complexation of Pr(III) and Nd(III) with glycyl-glycine (gly-gly) using spectral analysis of 4f-4f transitions and potentiometric titrations

    NASA Astrophysics Data System (ADS)

    Ranjana Devi, N.; Huidrom, Bimola; Rajmuhon Singh, N.

    2012-10-01

    The interaction of gly-gly with Pr(III) and Nd(III) have been studied in different aquated organic solvents like CH3OH, CH3CN, dioxane and DMF by using 4f-4f transitions spectra. Various energy interaction parameters like Slater Condon (Fk), Racah (Ek), Lande (ξ4f), nephelauxetic effect (β), bonding (b1/2) and percent covalency (δ) parameters have been calculated to explain the nature of complexation. The intensity parameters like oscillator strength (P) and Judd-Ofelt parameters (Tλ, λ = 2, 4, 6) also support the mode of binding of gly-gly to metal ions. The results show that Pr(III) and Nd(III) with gly-gly form complexes by ionic linkages with carboxylate anion with weak covalency. The protonation constants and metal-ligand stability constants have also been determined by potentiometric measurements in aqueous medium at different temperatures (290, 300 and 310 K) at constant ionic strength, 0.1 mol dm-1. The results show the formation of metal-ligand complexes in the stoichiometric ratio 1:1. The stability of complexes is more in Nd(III) complexes as compared to Pr(III) complexes. Thermodynamic parameters (ΔG, ΔH and ΔS) of complexes were also calculated and the negative values of ΔG and ΔH show that the complex reactions are spontaneous and exothermic. The positive values of ΔS indicate high stability of complex reactions which are enthalpy-driven.

  1. Effect of Short Study Abroad Course on Student Openness to Diversity

    ERIC Educational Resources Information Center

    Ismail, Baraem; Morgan, Mark; Hayes, Kirby

    2006-01-01

    An important contributing factor to students' willingness to work with diverse people is their "openness" to diversity. The objective of this study was to test the effect of a short (3-wk) study abroad course to China on the openness to diversity/challenge of the 23 students participating in the China study abroad course. Students were given the…

  2. Tocotrienol Treatment in Familial Dysautonomia: Open-Label Pilot Study.

    PubMed

    Cheishvili, David; Maayan, Channa; Holzer, Naama; Tsenter, Jeanna; Lax, Elad; Petropoulos, Sophie; Razin, Aharon

    2016-07-01

    Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy, primarily presented in Ashkenazi Jews. The most common mutation in FD patients results from a single base pair substitution of an intronic splice site in the IKBKAP gene which disrupts normal mRNA splicing and leads to tissue-specific reduction of IKBKAP protein (IKAP). To date, treatment of FD patients remains preventative, symptomatic and supportive. Based on previous in vitro evidence that tocotrienols, members of the vitamin E family, upregulate transcription of the IKBKAP gene, we aimed to investigate whether a similar effects was observed in vivo. In the current study, we assessed the effects of tocotrienol treatment on FD patients' symptoms and IKBKAP expression in white blood cells. The initial daily doses of 50 or 100 mg tocotrienol, doubled after 3 months, was administered to 32 FD patients. Twenty-eight FD patients completed the 6-month study. The first 3 months of tocotrienol treatment was associated with a significant increase in IKBKAP expression level in FD patients' blood. Despite doubling the dose after the initial 3 months of treatment, IKBKAP expression level returned to baseline by the end of the 6-month treatment. Clinical improvement was noted in the reported clinical questionnaire (with regard to dizziness, bloching, sweating, number of pneumonia, cough episodes, and walking stability), however, no significant effect was observed in any clinical measurements (weight, height, oxygen saturation, blood pressure, tear production, histamine test, vibration threshold test, nerve conduction, and heart rate variability) following Tocotrienol treatment. In conclusion, tocotrienol treatment appears significantly beneficial by clinical evaluation for some FD patients in a few clinical parameters; however it was not significant by clinical measurements. This open-label study shows the complexity of effect of tocotrienol treatment on FD patients' clinical outcomes and on

  3. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : III. A QUANTITATIVE STUDY AND A THEORY OF THE REACTION MECHANISM.

    PubMed

    Heidelberger, M; Kendall, F E

    1935-03-31

    The precipitin reaction between the specific polysaccharide of Type III pneumococcus and homologous antibody formed in the horse can be accounted for quantitatively by assuming the chemical combination of the components in a bimolecular reaction, followed by a series of competing bimolecular reactions which depend upon the relative proportions of the components. These reactions would lead to the formation of larger and larger aggregates until precipitation ultimately occurred. The mathematical formulation of this theory on the basis of the mass law is described. The derived expressions are shown to be in accord with the experimental findings and the constants used in these expressions are shown to have definite significance. In spite of the wide variation in the properties of individual sera these expressions permit the complete description of the behavior of an unknown serum with S III without an unduly burdensome number of analyses. The quantitative theory presented has been found applicable to other instances of the precipitin reaction, as will be shown in subsequent papers.

  4. Anisotropy of the nitrogen conduction states in the group III nitrides studied by polarized x-ray absorption

    SciTech Connect

    Lawniczak-Jablonska, K. |; Liliental-Weber, Z.; Gullikson, E.M.

    1997-04-01

    Group III nitrides (AlN, GaN, and InN) consist of the semiconductors which appear recently as a basic materials for optoelectronic devices active in the visible/ultraviolet spectrum as well as high-temperature and high-power microelectronic devices. However, understanding of the basic physical properties leading to application is still not satisfactory. One of the reasons consists in unsufficient knowledge of the band structure of the considered semiconductors. Several theoretical studies of III-nitrides band structure have been published but relatively few experimental studies have been carried out, particularly with respect to their conduction band structure. This motivated the authors to examine the conduction band structure projected onto p-states of the nitrogen atoms for AlN, GaN and InN. An additional advantage of their studies is the availability of the studied nitrides in two structures, hexagonal (wurtzite) and cubic (zincblende). This offers an opportunity to gain information about the role of the anisotropy of electronic band states in determining various physical properties.

  5. Synthesis Characterization and Decomposition Studies of tris[N-N-dibenzyidithocarbaso)Indium (III) Chemical Spray Deposition of Polycrystalline CuInS2 on Copper Films

    NASA Technical Reports Server (NTRS)

    Hehemann, David G.; Lau, J. Eva; Harris, Jerry D.; Hoops, Michael D.; Duffy, Norman V.

    2005-01-01

    This paper presents the results of the synthesis characterization and decomposition studies of tris[N-N-dibenzyidithocarbaso)Indium (III) with chemical spray deposition of polycrystalline CuInS2 on Copper Films.

  6. Comparative 4f-4f absorption spectral study for the interactions of Nd(III) with some amino acids: Preliminary thermodynamics and kinetic studies of interaction of Nd(III):glycine with Ca(II)

    NASA Astrophysics Data System (ADS)

    Moaienla, T.; Bendangsenla, N.; David Singh, Th.; Sumitra, Ch.; Rajmuhon Singh, N.; Indira Devi, M.

    2012-02-01

    Spectral analysis of Nd(III) complexes with some amino acids viz.; glycine, L-alanine, L-phenylalanine and L-aspartic acid in the presence and absence of Ca 2+ was carried out in some organic solvents; CH 3OH, CH 3CN, DMF and dioxane using comparative absorption spectra of 4f-4f transitions. The study was carried out by evaluating various energy interaction parameters like Slator-Condon ( Fk), Lande factor ( ξ4f), nephelauxetic ratio ( β), bonding parameter ( b1/2), percent-covalency ( δ) by applying partial and multiple regression analysis. The values of oscillator strength ( Pobs) and Judd-Ofelt electric dipole intensity parameter Tλ ( λ = 2, 4, 6) for different 4f-4f transitions have been calculated. On analysis of the variation of the various energy interaction parameters as well as the changes in the oscillator strength ( Pobs) and Tλ values, reveal the mode of binding with the different ligands. Kinetic studies for the complexation of Nd(III):glycine:Ca(II) have also been discussed at different temperatures in DMF medium and from it the values of activation energy ( Ea) and thermodynamic parameters like Δ H°, Δ S° and Δ G° for the complexation are evaluated.

  7. Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis

    SciTech Connect

    Grigsby, P.W.; Pilepich, M.V.; Parsons, C.L. )

    1990-02-01

    This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. A complete response was obtained in 82%, a partial response occurred in 9%, and 9% failed to respond to therapy. No significant toxicity was observed. It is concluded that PPS is an effective treatment for chronic radiation-induced proctitis and a phase III randomized, double-blind study of PPS versus placebo is planned.

  8. Communicating the Open Access Message: A Case Study from Ireland

    ERIC Educational Resources Information Center

    Lawton, Aoife

    2016-01-01

    Since 2009, Open Access (OA) Week has been celebrated worldwide in October each year. It is an opportunity for librarians to engage with the research community and demonstrate the value that they bring to their organisations in the area of disseminating scholarly output. Although thousands of events have been held since the inception of OA Week, a…

  9. OpenCourseWare Resources for Advanced High School Study

    ERIC Educational Resources Information Center

    Carson, Steve

    2008-01-01

    In 2000, the Massachusetts Institute of Technology (MIT) faculty first proposed putting the course materials from all 1,800 MIT classes online, free of charge. The idea behind MIT OpenCourseWare (OCW) was to use the Internet for more than just distance learning. When MIT began placing the course materials online in 2002 and 2003, the audience…

  10. Open Source Projects in Software Engineering Education: A Mapping Study

    ERIC Educational Resources Information Center

    Nascimento, Debora M. C.; Almeida Bittencourt, Roberto; Chavez, Christina

    2015-01-01

    Context: It is common practice in academia to have students work with "toy" projects in software engineering (SE) courses. One way to make such courses more realistic and reduce the gap between academic courses and industry needs is getting students involved in open source projects (OSP) with faculty supervision. Objective: This study…

  11. Welding III.

    ERIC Educational Resources Information Center

    Allegheny County Community Coll., Pittsburgh, PA.

    Instructional objectives and performance requirements are outlined in this course guide for Welding III, an advanced course in arc welding offered at the Community College of Allegheny County to provide students with the proficiency necessary for industrial certification. The course objectives, which are outlined first, specify that students will…

  12. Dysprosium(III)-Catalyzed Ring-Opening of meso-Epoxides: Desymmetrization by Remote Stereocontrol in a Thiolysis/Elimination Sequence.

    PubMed

    Yao, Lu; Zhu, Qiao; Wei, Liang; Wang, Zuo-Fei; Wang, Chun-Jiang

    2016-05-01

    An unprecedented asymmetric desymmetrization of meso-epoxides, derived from cyclopentene-1,3-diones, with 2-mercaptobenzothiazoles has been realized. It was efficiently catalyzed by a chiral Dy(III) /N,N'-dioxide complex through a thiolysis/elimination sequence. This remote stereocontrol strategy provides facile access to synthetically versatile cyclopentene derivatives bearing an all-carbon quaternary stereogenic center in high yield and excellent enantioselectivity. Intriguingly, optically active thiophene could be readily generated from the obtained product through an efficient one-pot protocol. PMID:27060603

  13. Dysprosium(III)-Catalyzed Ring-Opening of meso-Epoxides: Desymmetrization by Remote Stereocontrol in a Thiolysis/Elimination Sequence.

    PubMed

    Yao, Lu; Zhu, Qiao; Wei, Liang; Wang, Zuo-Fei; Wang, Chun-Jiang

    2016-05-01

    An unprecedented asymmetric desymmetrization of meso-epoxides, derived from cyclopentene-1,3-diones, with 2-mercaptobenzothiazoles has been realized. It was efficiently catalyzed by a chiral Dy(III) /N,N'-dioxide complex through a thiolysis/elimination sequence. This remote stereocontrol strategy provides facile access to synthetically versatile cyclopentene derivatives bearing an all-carbon quaternary stereogenic center in high yield and excellent enantioselectivity. Intriguingly, optically active thiophene could be readily generated from the obtained product through an efficient one-pot protocol.

  14. Membrane perturbation: studies employing a calcium-sensitive dye, arsenazo III, in liposomes.

    PubMed Central

    Weissmann, G; Collins, T; Evers, A; Dunham, P

    1976-01-01

    A metallochromic dye, arsenazo III [2,7-bis-(2-arsonophenylazo)-1,8-dihydroxynaphthalene-3,6-disulfonic acid], has been incorporated into the aquenous interspaces of multilamellar liposomes. multilamellar liposomes. Addition of Ca produced no shift in the absorbance spectrum of dye captured by liposomes, whereas disruption of liposomes by Triton X-100, followed by Ca, produced the spectrum chracteristic of the dye-Ca complex: evidence of latency. Addition of excess ethyleneglycol-bis(beta-aminoethyl ether)-N,N'-tetraacetic acid (EGTA) reversed the spectal shift. Differences between spectra obtained in this sequence yielded dye efflus. To measure Ca efflux, difference spectra (+/-EGTA) were obtained from cationic liposomes containing Ca after detergent lysis (sensitivity less than 10 mmol/ml). Since liposomes were impermeable either to dye or Ca until perturbed, it was possible to test a variety of membrane-active steroids (diethylstilbesterol, deoxycorticosterone, etiocholanolone) for their capacity to provoke dye efflux from liposomes; preincorporation of cortisol stablized liposomes against dye leak. Immunoglobulin-coated liposomes containing dye were taken up by phagocytes of Mustelus canis, and phagocytic vacuoles stained red-purple after ingestions. Liposomes containing the calcium-sensitive dye constitute a simple, accurate means for determining membrane perturbation and Ca fluxes; their uptake by cells or organelles remains to be exploited further. PMID:1061152

  15. Structural, Hirshfeld surface and spectroscopic studies of the noncentrosymmetric 1-ethylpiperazinediium pentachloroantimonate (III) monohydrate

    NASA Astrophysics Data System (ADS)

    Soudani, S.; Zeller, M.; Jelsch, C.; Lefebvre, F.; Ben Nasr, Cherif

    2016-08-01

    1-Ethylpiperazinediium pentachloroantimonate (III) monohydrate, C6H16N2SbCl5·H2O, has been synthesized by the reaction of antimony trioxide (Sb2O3) and 1-ethylpiperazine in an aqueous solution of hydrochloric acid. The structure crystallizes in orthorhombic system, in the non-centrosymmetric space group Pca21 and consists of isolated [C6H16N2]2+ cations, square pyramidal [SbCl5]2- anions and lattice water molecules. Osbnd H⋯Cl hydrogen bonds link the [SbCl5]2- anions and water molecules to form double chains stretching along the [101] direction. The chains in turn are linked to the organic cations via Nsbnd H⋯Cl, Csbnd H⋯Cl, Csbnd H⋯O and Nsbnd H⋯O hydrogen bonds to form a three-dimensional network. This structure presents an example of a general square pyramidal complex ion containing a stereo-chemically active lone pair of electrons. Solid state 13C and 15N CP-MAS NMR spectra are in agreement with the X-ray structure, and vibrational absorption bands were identified by infrared spectroscopy. DFT calculations allowed the attribution of the NMR peaks and IR absorption bands. The interactions variability of the two independent cations and ten chloride atoms is analyzed via Hirshfeld surface analysis.

  16. Study of equilibrium properties of Cr(III)/polyacrylamide gels by swelling measurement and equilibrium dialysis

    SciTech Connect

    Young, T.S.; Hunt, J.A.; Green, D.W.; Willhite, G.P. )

    1989-08-01

    In observations of the long-term properties of a series of Cr(III)/polyacrylamide (PAAM) gels, the gels either underwent syneresis upon aging or swelled in contact with excess brine. Both syneresis and swelling can substantially change the volume and properties of a gel placed in a formation and therefore influence the effectiveness of a crosslinked-polymer treatment. Efforts were made to develop an understanding of these phenomena and to describe them in terms of the gel's physical and chemical states. A long-term gel's physical and chemical states are characterized by two parameters, effective crosslinking density and chromium density, determined by equilibrium swelling and equilibrium dialysis, respectively. Swelling and syneresis properties were correlated to the effective cross-linking density described in polymer network theory. A model based on Flory and Hermans' swelling equations was developed to calculate the effective crosslinking densities of gels prepared from solution. Attempts were made to relate the swelling and syneresis properties to the compositions of gel systems to allow prediction of long-term stability of a gel based on its composition. An analysis of the amount of chromium that reacted with the PAAM was made by successive equilibrium dialyses of the gel followed by chromium analyses of dialysates by atomic and visible absorptions.

  17. Spectroscopic studies of micelle-enhanced ligand exchange of gallium (III)/4-(2-pyridylazo) resorcinol complex by calf thymus DNA

    NASA Astrophysics Data System (ADS)

    Romeika, Jennifer M.; Spurgeon, Charina L.; Yan, Fei

    2014-01-01

    The effect of cationic micelles of cetyltrimethylammonium bromide (CTAB) on the interaction of gallium (III) with 4-(2-pyridylazo) resorcinol (PAR) under varying conditions has been studied spectrophotometrically. At pH 6.0, CTAB (0.05% w/v) markedly enhanced the absorption intensity of gallium (III)-PAR complex. Furthermore, the introduction of CTAB provided unique selectivity for the ligand exchange of Ga(III)-PAR by calf thymus dsDNA over calf thymus ssDNA. This phenomenon offers a novel spectrophotometric sensing strategy for direct detection of dsDNA.

  18. Spectroscopic studies of micelle-enhanced ligand exchange of gallium (III)/4-(2-pyridylazo) resorcinol complex by calf thymus DNA.

    PubMed

    Romeika, Jennifer M; Spurgeon, Charina L; Yan, Fei

    2014-01-01

    The effect of cationic micelles of cetyltrimethylammonium bromide (CTAB) on the interaction of gallium (III) with 4-(2-pyridylazo) resorcinol (PAR) under varying conditions has been studied spectrophotometrically. At pH 6.0, CTAB (0.05% w/v) markedly enhanced the absorption intensity of gallium (III)-PAR complex. Furthermore, the introduction of CTAB provided unique selectivity for the ligand exchange of Ga(III)-PAR by calf thymus dsDNA over calf thymus ssDNA. This phenomenon offers a novel spectrophotometric sensing strategy for direct detection of dsDNA.

  19. Physicochemical study of floranol, its copper(II) and iron(III) complexes, and their inhibitory effect on LDL oxidation.

    PubMed

    Botelho, Françoise V; Alvarez-Leite, Jacqueline I; Lemos, Virginia S; Pimenta, Adriano M C; Calado, Hállen D R; Matencio, Tulio; Miranda, Cristiano T; Pereira-Maia, Elene C

    2007-06-01

    The antioxidant activity of floranol (3,5,7,2'-tetrahydroxy-6-methoxy-8-prenylflavanone), a new flavonoid isolated from the roots of Dioclea grandiflora, was evaluated by the inhibition of human low-density lipoprotein (LDL) oxidation. Floranol increased its oxidation lag-phase significantly in a dose-dependent manner. As the antioxidant mechanism may involve metal coordination, we have undertaken a detailed study of floranol interactions with Cu(II) and Fe(III) by combination of UV-visible (UV-Vis) and mass spectrometries and cyclic voltammetry. The acidity constants of the ligand as well as the stability constants of the metal complexes were calculated. The pKa values of 6.58, 11.97 and 13.87 were determined and the following acidity order is proposed 7-OH>5-OH>2'-OH. The best fit between experimental and calculated spectra was obtained assuming the formation of two Cu(II) complexes: [CuL] logbeta=19.34+/-0.05 and [CuL(2)](2-) logbeta=26.4+/-0.10 and three Fe(III) complexes: [FeL(3)](3-) logbeta=44.72+/-0.09, [FeL(2)](-) logbeta=35.32+/-0.08 and [FeL](+) logbeta=19.51+/-0.04. In addition, copper and iron reduction is less favorable in the presence of floranol. These results indicate that floranol can efficiently bind Cu(II) and Fe(III) ions thus preventing their effect on LDL oxidation. PMID:17462741

  20. A Phase I Study of Dasatinib with Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer

    PubMed Central

    Khurshid, Humera; Dipetrillo, Thomas; Ng, Thomas; Mantripragada, Kalyan; Birnbaum, Ariel; Berz, David; Radie-Keane, Kathy; Perez, Kimberly; Constantinou, Maria; Luppe, Denise; Schumacher, Andrew; Leonard, Kara; Safran, Howard

    2012-01-01

    Objectives: Src family kinases (SFKs) are expressed in non-small cell lung cancer (NSCLC) and may be involved in tumor growth and metastases. Inhibition of SFK may also enhance radiation. The purpose of this study was to evaluate if a maximum dose of 100 mg of dasatinib could be safely administered with concurrent chemoradiation and then continued as maintenance for patients with newly diagnosed stage III NSCLC. Methods: Patients with stage III locally advanced NSCLC received paclitaxel, 50 mg/m2/week, with carboplatin area under the curve (AUC) = 2, weekly for 7 weeks, and concurrent radiotherapy, 64.8 Gy. Three dose levels of dasatinib 50, 70, and 100 mg/day were planned. Results: 11 patients with locally advanced NSCLC were entered. At the 70 mg dose level 1 patient had grade 5 pneumonitis not responsive to therapy, and one patient had reversible grade 3 pneumonitis and grade 3 pericardial effusion. Due to these toxicities the Brown University Oncology Group Data Safety Monitoring Board terminated the study. Conclusion: Dasatinib could not be safely combined with concurrent chemoradiation for stage 3 lung cancer due to pneumonitis. PMID:22666662

  1. Once-daily USL255 as adjunctive treatment of partial-onset seizures: Randomized phase III study

    PubMed Central

    Chung, Steve S; Fakhoury, Toufic A; Hogan, R Edward; Nagaraddi, Venkatesh N; Blatt, Ilan; Lawson, Balduin; Arnold, Stephan; Anders, Bob; Clark, Annie M; Laine, Dawn; Meadows, R Shawn; Halvorsen, Mark B

    2014-01-01

    Objective To evaluate the efficacy and safety of USL255, Qudexy™ XR (topiramate) extended-release capsules, as an adjunctive treatment for refractory partial-onset seizures (POS) in adults taking one to three concomitant antiepileptic drugs. Methods In this global phase III study (PREVAIL; NCT01142193), 249 adults with POS were randomized 1:1 to once-daily USL255 (200 mg/day) or placebo. The primary and key secondary efficacy endpoints were median percent reduction in weekly POS frequency and responder rate (proportion of patients with ≥50% reduction in seizure frequency). Seizure freedom was also assessed. Safety (adverse events, clinical and laboratory findings), as well as treatment effects on quality of life (QOLIE-31-P) and clinical global impression of change (CGI-C), were evaluated. Results Across the entire 11-week treatment phase, USL255 significantly reduced the median percent seizure frequency and significantly improved responder rate compared with placebo. Efficacy over placebo was observed early in treatment, in patients with highly refractory POS, and in those with the most debilitating seizure types (i.e., complex partial, partial secondarily generalized). USL255 was safe and generally well tolerated with a low incidence of neurocognitive adverse events. USL255 was associated with significant clinical improvement without adversely affecting quality of life. Significance The PREVAIL phase III clinical study demonstrated that once-daily USL255 (200 mg/day) significantly improved seizure control and was safe and generally well tolerated with few neurocognitive side effects. PMID:24902983

  2. Microwave assisted synthesis, spectroscopic, electrochemical and DNA cleavage studies of lanthanide(III) complexes with coumarin based imines.

    PubMed

    Kapoor, Puja; Fahmi, Nighat; Singh, R V

    2011-12-01

    The present work stems from our interest in the synthesis, characterization and biological evaluation of lanthanide(III) complexes of a class of coumarin based imines which have been prepared by the interaction of hydrated lanthanide(III) chloride with the sodium salts of 3-acetylcoumarin thiosemicarbazone (ACTSZH) and 3-acetylcoumarin semicarbazone (ACSZH) in 1:3 molar ratio using thermal as well as microwave method. Characterization of the ligands as well as the metal complexes have been carried out by elemental analysis, melting point determinations, molecular weight determinations, magnetic moment, molar conductance, IR, (1)H NMR, (13)C NMR, electronic, EPR, X-ray powder diffraction and mass spectral studies. Spectral studies confirm ligands to be monofunctional bidentate and octahedral environment around metal ions. The redox behavior of one of the synthesized metal complex was investigated by cyclic voltammetry. Further, free ligands and their metal complexes have been screened for their antimicrobial as well as DNA cleavage activity. The results of these findings have been presented and discussed.

  3. Microwave assisted synthesis, spectroscopic, electrochemical and DNA cleavage studies of lanthanide(III) complexes with coumarin based imines

    NASA Astrophysics Data System (ADS)

    Kapoor, Puja; Fahmi, Nighat; Singh, R. V.

    2011-12-01

    The present work stems from our interest in the synthesis, characterization and biological evaluation of lanthanide(III) complexes of a class of coumarin based imines which have been prepared by the interaction of hydrated lanthanide(III) chloride with the sodium salts of 3-acetylcoumarin thiosemicarbazone (ACTSZH) and 3-acetylcoumarin semicarbazone (ACSZH) in 1:3 molar ratio using thermal as well as microwave method. Characterization of the ligands as well as the metal complexes have been carried out by elemental analysis, melting point determinations, molecular weight determinations, magnetic moment, molar conductance, IR, 1H NMR, 13C NMR, electronic, EPR, X-ray powder diffraction and mass spectral studies. Spectral studies confirm ligands to be monofunctional bidentate and octahedral environment around metal ions. The redox behavior of one of the synthesized metal complex was investigated by cyclic voltammetry. Further, free ligands and their metal complexes have been screened for their antimicrobial as well as DNA cleavage activity. The results of these findings have been presented and discussed.

  4. A comparative study of affibody, panitumumab, and EGF for near-infrared fluorescence imaging of EGFR- and EGFRvIII-expressing tumors.

    PubMed

    Gong, Haibiao; Kovar, Joy L; Cheung, Lael; Rosenthal, Eben L; Olive, D Michael

    2014-02-01

    Aberrant overexpression and/or activation of epidermal growth factor receptor (EGFR) is associated with many types of cancers. EGFR variant III (EGFRvIII) is a common in-frame deletion mutant, which lacks a large part of the extracellular portion (exons 2-7), including components of the ligand-binding domain. Although EGFR has been extensively studied as a molecular imaging target, information about EGFRvIII-targeted molecular imaging is lacking. In this study, the EGFR-specific affibody, therapeutic antibody panitumumab, and ligand EGF were labeled with IRDye 800CW (Ex/Em: 774/789 nm), yielding Aff800, Pan800, and EGF800, respectively. The binding affinities of the labeled agents were compared in cell-based assays using a rat glioma cell line F98 parental (F98-p) lacking EGFR expression, and 2 F98-derived transgenic cell lines expressing EGFR or EGFRvIII (designated as F98-EGFR and F98-vIII, respectively). Results showed that all agents could bind to F98-EGFR, with Pan800 having the highest binding affinity, followed by Aff800 and EGF800. Pan800 and Aff800, but not EGF800, also bound to F98-vIII. In vivo animal imaging demonstrated that compared with F98-p tumors, F98-EGFR tumors generated higher signals with all three agents. However, in the case of F98-vIII, only Pan800 and Aff800 signals were higher. Analysis of tissue lysates showed that a large portion of Pan800 was degraded into small fragments in F98-EGFR and F98-vIII tumors, possibly due to proteolytic digestion after its specific binding and internalization. In conclusion, Pan800 and Aff800 could be used as imaging agents for both wild-type EGFR and EGFRvIII, whereas EGF800 only targets wild-type EGFR. PMID:24100437

  5. Synthesis, DNA binding, and cleavage studies of Co(III) complexes with fused aromatic NO/NN-containing ligands.

    PubMed

    Sudhamani, Chittanahalli N; Bhojya Naik, Halehatty S; Girija, D

    2012-01-01

    Four new Co(III) complexes, namely [Co(cq)(3)](PF(6))(3), [Co(phen)(2)(cq)](PF(6))(3), [Co(bnp)(3)] (PF(6))(3), and [Co(phen)(2)(bnp)](PF(6))(3) (where cq = chromeno[2,3-b]quinoline, phen = 1,10-phenanthroline and bnp = dibenzo[b,g][1,8]naphthyridine), were synthesized and structurally characterized. Spectroscopic data suggested an octahedral geometry for all the complexes. Binding studies of these complexes with double-stranded (ds)DNA were analyzed by absorption spectra, viscosity, and thermal denaturation studies. The results revealed that the metal complex intercalates into the DNA base stack as intercalator. The oxidative cleavage activities of the complexes were studied with supercoiled pUC19 DNA using gel electrophoresis and the results show that the complexes have potent nuclease activity.

  6. Open Mind, Open Heart: An Anthropological Study of the Therapeutics of Meditation Practice in the US.

    PubMed

    Myers, Neely; Lewis, Sara; Dutton, Mary Ann

    2015-09-01

    Based on ethnographic fieldwork and interviews collected with meditation teachers and students in the United States, this article will argue that active training in meditation-based practices occasions the opportunity for people with traumatic stress to develop a stronger mind-body connection through heightened somatic awareness and a focus on the present moment that they find to be therapeutic. Three important themes related to healing through meditation for trauma emerged from the data and centered around the ways our interlocutors attempted to realign their sense of self, mind and body, after a traumatic experience. The themes helped explain why US women perceive meditation as therapeutic for trauma, namely that the practice of meditation enables one to focus on the lived present rather than traumatic memories, to accept pain and "open" one's heart, and to make use of silence instead of speech as a healing modality. As meditation practices increasingly enter global popular culture, promoted for postulated health benefits, the driving question of this research--how meditation may perpetuate human resilience for women who have experienced trauma based on their own perspectives of meditation practices--is a critical addition to the literature.

  7. ERA's Open Rotor Studies Including Shielding for Noise Reduction

    NASA Technical Reports Server (NTRS)

    Van Zante, Dale; Thomas, Russell

    2012-01-01

    The Open Rotor is a modern version of the UnDucted Fan (UDF) that was flight tested in the late 1980's through a partnership between NASA and General Electric (GE). Tests were conducted in the 9' x 15' Low Speed Wind Tunnel and the 8' x 6' Supersonic Wind Tunnel starting in late 2009 and completed in early 2012. Aerodynamic and acoustic data were obtained for takeoff, approach and cruise simulations. GE was the primary partner, but other organizations were involved such as Boeing and Airbus who provided additional hardware for fuselage simulations. This test campaign provided the acoustic and performance characteristics for modern open rotor blades designs." NASA and GE conducted joint systems analysis to evaluate how well new blade designs would perform on a B737 class aircraft, and compared the results to an advanced higher bypass ratio turbofan." Acoustic shielding experiments were performed at NASA GRC and Boeing LSAF facilities to provide data for noise estimates of unconventional aircraft configurations with Open Rotor propulsion systems." The work was sponsored by NASA's aeronautics programs, including the Subsonic Fixed Wing (SFW) and the Environmentally Responsible Aviation (ERA) projects."

  8. Reaction between Chromium(III) and EDTA Ions: an Overlooked Mechanism of Case Study Reaction of Chemical Kinetics.

    PubMed

    Cerar, Janez

    2015-01-01

    Widely cited and accepted explanation of reaction mechanism of the case study reaction of chemical kinetics between Cr(III) ions and ethylenediaminetetraacetic acid (EDTA) contradicts modern chromium(III) coordination chemistry data. Absorption UV and visible light spectra were recorded during the reaction between aqueous solution of Cr(NO(3))(3) and EDTA in order to obtain new information about this reaction. Analysis of the spectra showed that only very small fraction of intermediates may be present in solution during the course of the reaction. The reaction scheme was established and according to it calculations based on a simplified model were carried out. Literature data for constants were used if known, otherwise, adjusted values of their sound estimates were applied. Reasonable agreement of the model calculations with the experimental data was obtained for pH values 3.8 and 4.5 but the model failed to reproduce measured rate of reaction at pH 5.5, probably due to the use of the oversimplified model. PMID:26454587

  9. DFT modeling and spectroscopic study of metal ligand bonding in La(III) complex of coumarin-3-carboxylic acid

    NASA Astrophysics Data System (ADS)

    Mihaylov, Tz.; Trendafilova, N.; Kostova, I.; Georgieva, I.; Bauer, G.

    2006-09-01

    The binding mode of coumarin-3-carboxylic acid (HCCA) to La(III) is elucidated at experimental and theoretical level. The complexation ability of the deprotonated ligand (CCA -) to La(III) is studied using elemental analysis, DTA and TGA data as well as FTIR, 1H NMR and 13C NMR spectra. The experimental data suggest the complex formula La(CCA) 2(NO 3)(H 2O) 2. B3LYP, BHLYP, B3P86, B3PW91, PW91P86 and MPW1PW91 functionals are tested for geometry and frequency calculations of the neutral ligand and all of them show bond length deviations bellow 1%. B3LYP/6-31G(d) level combined with large quasi-relativistic effective core potential for lanthanum is selected to describe the molecular, electronic and vibrational structures as well as the conformational behavior of HCCA, CCA - and La-CCA complex. The metal-ligand binding mode is predicted through molecular modeling and energy estimation of different La-CCA structures. The calculated atomic charges and the bonding orbital polarizations point to strong ionic metal-ligand bonding in La-CCA complex and insignificant donor acceptor interaction. Detailed vibrational analysis of HCCA, CCA - and La(CCA) 2(NO 3)(H 2O) 2 systems based on both calculated and experimental frequencies confirms the suggested metal-ligand binding mode.

  10. Reaction between Chromium(III) and EDTA Ions: an Overlooked Mechanism of Case Study Reaction of Chemical Kinetics.

    PubMed

    Cerar, Janez

    2015-01-01

    Widely cited and accepted explanation of reaction mechanism of the case study reaction of chemical kinetics between Cr(III) ions and ethylenediaminetetraacetic acid (EDTA) contradicts modern chromium(III) coordination chemistry data. Absorption UV and visible light spectra were recorded during the reaction between aqueous solution of Cr(NO(3))(3) and EDTA in order to obtain new information about this reaction. Analysis of the spectra showed that only very small fraction of intermediates may be present in solution during the course of the reaction. The reaction scheme was established and according to it calculations based on a simplified model were carried out. Literature data for constants were used if known, otherwise, adjusted values of their sound estimates were applied. Reasonable agreement of the model calculations with the experimental data was obtained for pH values 3.8 and 4.5 but the model failed to reproduce measured rate of reaction at pH 5.5, probably due to the use of the oversimplified model.

  11. Enantiopure tetranuclear iron(III) complexes using chiral reduced Schiff base ligands: synthesis, structure, spectroscopy, magnetic properties, and DFT studies.

    PubMed

    Singh, Reena; Banerjee, Atanu; Colacio, Enrique; Rajak, Kajal Krishna

    2009-06-01

    Four new tetranuclear iron(III) complexes of formula [{Fe(L)(2)}(3)Fe], 1-4, have been prepared by reacting [Fe(ClO(4))(3)].6H(2)O with H(2)L in methanol. Here, L(2-) is the deprotonated form of N-(2-hyrdoxybenzyl)-l-valinol (H(2)L(1)), N-(2-hyrdoxybenzyl)-l-leucinol (H(2)L(2)), N-(5-chloro-2-hyrdoxybenzyl)-l-leucinol (H(2)L(3)), and N-(2-hyrdoxybenzyl)-l-phenylalaninol (H(2)L(4)). The complexes are prepared in an enantiomeric pure form. The complexes have been characterized with the help of IR, UV-vis, circular dichroism (CD), (1)H, and elemental analyses. The complex [{Fe(L(2))(2)}(3)Fe].CH(3)OH.2H(2)O, 2.CH(3)OH.2H(2)O, crystallizes in enantiomeric pure form containing a propeller-like Fe(4)O(6) core. (1)H and CD spectral studies of the four species are consistent with the structural similarities of the complexes in solution. Variable-temperature magnetic susceptibility of one case shows an intramolecular antiferromagnetic coupling between the Fe(III) ions. Magnetic measurements are in accord with the S = 5 ground state and suggest single molecular magnet behavior. The magnetic exchange coupling constant between the iron centers within the molecule is interpreted using broken-symmetry density functional theory calculation. PMID:19466801

  12. Electronic Band Structures of the Highly Desirable III-V Semiconductors: TB-mBJ DFT Studies

    NASA Astrophysics Data System (ADS)

    Rehman, Gul; Shafiq, M.; Saifullah; Ahmad, Rashid; Jalali-Asadabadi, S.; Maqbool, M.; Khan, Imad; Rahnamaye-Aliabad, H.; Ahmad, Iftikhar

    2016-07-01

    The correct band gaps of semiconductors are highly desirable for their effective use in optoelectronic and other photonic devices. However, the experimental and theoretical results of the exact band gaps are quite challenging and sometimes tricky. In this article, we explore the electronic band structures of the highly desirable optical materials, III-V semiconductors. The main reason of the ineffectiveness of the theoretical band gaps of these compounds is their mixed bonding character, where large proportions of electrons reside outside atomic spheres in the intestinal regions, which are challenging for proper theoretical treatment. In this article, the band gaps of the compounds are revisited and successfully reproduced by properly treating the density of electrons using the recently developed non-regular Tran and Blaha's modified Becke-Johnson (nTB-mBJ) approach. This study additionally suggests that this theoretical scheme could also be useful for the band gap engineering of the III-V semiconductors. Furthermore, the optical properties of these compounds are also calculated and compared with the experimental results.

  13. Forty-five years of open plan office experience: An unusual case study

    NASA Astrophysics Data System (ADS)

    Paoletti, Dennis A.

    2005-09-01

    The open plan office design concept has been around for at least 45 years. Through research, design, and practical experience, the basic concepts and parameters that impact acoustics and speech privacy have been fairly well developed and documented. The psychological aspects of human response and expectation to open plan environments, and the conceptual designs that emerge from the architect and interior designers are frontiers that still allow for ongoing study. A large open plan project completed during the dot-com bubble allowed an opportunity to design and experience an unusual open plan environment that utilized exposed sound masking system loudspeakers and minimal sound absorption.

  14. Surface X-Ray Diffraction Results on the III-V Droplet Heteroepitaxy Growth Process for Quantum Dots: Recent Understanding and Open Questions

    SciTech Connect

    Cohen, Eyal; Elfassy, Naomi; Koplovitz, Guy; Yochelis, Shira; Shusterman, Sergey; Kumah, Divine P.; Yacoby, Yizhak; Clarke, Roy; Paltiel, Yossi

    2011-11-08

    In recent years, epitaxial growth of self-assembled quantum dots has offered a way to incorporate new properties into existing solid state devices. Although the droplet heteroepitaxy method is relatively complex, it is quite relaxed with respect to the material combinations that can be used. This offers great flexibility in the systems that can be achieved. In this paper we review the structure and composition of a number of quantum dot systems grown by the droplet heteroepitaxy method, emphasizing the insights that these experiments provide with respect to the growth process. Detailed structural and composition information has been obtained using surface X-ray diffraction analyzed by the COBRA phase retrieval method. A number of interesting phenomena have been observed: penetration of the dots into the substrate (“nano-drilling”) is often encountered; interdiffusion and intermixing already start when the group III droplets are deposited, and structure and composition may be very different from the one initially intended.

  15. Pepper Heat Shock Protein 70a Interacts with the Type III Effector AvrBsT and Triggers Plant Cell Death and Immunity1[OPEN

    PubMed Central

    Kim, Nak Hyun; Hwang, Byung Kook

    2015-01-01

    Heat shock proteins (HSPs) function as molecular chaperones and are essential for the maintenance and/or restoration of protein homeostasis. The genus Xanthomonas type III effector protein AvrBsT induces hypersensitive cell death in pepper (Capsicum annuum). Here, we report the identification of the pepper CaHSP70a as an AvrBsT-interacting protein. Bimolecular fluorescence complementation and coimmunoprecipitation assays confirm the specific interaction between CaHSP70a and AvrBsT in planta. The CaHSP70a peptide-binding domain is essential for its interaction with AvrBsT. Heat stress (37°C) and Xanthomonas campestris pv vesicatoria (Xcv) infection distinctly induce CaHSP70a in pepper leaves. Cytoplasmic CaHSP70a proteins significantly accumulate in pepper leaves to induce the hypersensitive cell death response by Xcv (avrBsT) infection. Transient CaHSP70a overexpression induces hypersensitive cell death under heat stress, which is accompanied by strong induction of defense- and cell death-related genes. The CaHSP70a peptide-binding domain and ATPase-binding domain are required to trigger cell death under heat stress. Transient coexpression of CaHSP70a and avrBsT leads to cytoplasmic localization of the CaHSP70a-AvrBsT complex and significantly enhances avrBsT-triggered cell death in Nicotiana benthamiana. CaHSP70a silencing in pepper enhances Xcv growth but disrupts the reactive oxygen species burst and cell death response during Xcv infection. Expression of some defense marker genes is significantly reduced in CaHSP70a-silenced leaves, with lower levels of the defense hormones salicylic acid and jasmonic acid. Together, these results suggest that CaHSP70a interacts with the type III effector AvrBsT and is required for cell death and immunity in plants. PMID:25491184

  16. Chemical, radiochemical and biological studies of new gallium(III) complexes with hexadentate chelators.

    PubMed

    Silva, Francisco; Campello, Maria Paula C; Gano, Lurdes; Fernandes, Célia; Santos, Isabel C; Santos, Isabel; Ascenso, José R; João Ferreira, M; Paulo, António

    2015-02-21

    New N4O2-donor acyclic chelators 2-[[2-[2-(3,5-dimethylpyrazol-1-yl)ethyl-[2-[(2-hydroxyphenyl)methylamino]ethyl]amino]ethylamino]methyl]phenol (H2L(pz*,NH)) and 2-[[2-[2-[(2-hydroxyphenyl)methylamino]ethyl-(2-pyridylmethyl)amino]ethylamino]methyl]phenol (H2L(py,NH)) were obtained upon introduction of pyridyl or pyrazolyl coordinating units at the central nitrogen atom of diethylenetriamine (dien) and by functionalization of its terminal amines with phenol groups. The coordination behavior of H2L(pz*,NH) and H2L(py,NH) was evaluated towards (nat)Ga/(67)Ga, aiming to assess their suitability to obtain Ga(iii) chelates relevant for biomedical applications. Single crystal X-ray diffraction analysis of the complexes [GaL(pz*,NH)](ClO4) and [GaL(py,NH)](ClO4) confirmed the presence of N4O2-hexadentate chelators with the phenoxide groups coordinated cis relatively to the pyridyl/pyrazolyl arms. Unlike [GaL(pz*,NH)](ClO4), [GaL(py,NH)](ClO4) exists in solution as a mixture of isomers, as confirmed by several NMR techniques. The corresponding radiocomplex [(67)GaL(py,NH)](+) was obtained smoothly in almost quantitative radiochemical yield, contrary to [(67)GaL(pz*,NH)](+) that seems to be (hemi)labile under the same conditions. [(67)GaL(py,NH)](+) presents a high in vivo stability and a favourable biodistribution profile in mice. The imine congeners 2-[(E)-2-[2-(3,5-dimethylpyrazol-1-yl)ethyl-[2-[(E)-(2-hydroxyphenyl)methyleneamino]ethyl]amino]ethyliminomethyl]phenol (H2L(pz*,C[double bond, length as m-dash]N)) and 2-[(E)-2-[2-[(E)-(2-hydroxyphenyl)methyleneamino]ethyl-(2-pyridylmethyl)amino]ethyliminomethyl]phenol (H2L(py,C[double bond, length as m-dash]N)) were also evaluated but they did not form complexes compatible for biomedical applications owing to their high reactivity. PMID:25601139

  17. Chemical, radiochemical and biological studies of new gallium(III) complexes with hexadentate chelators.

    PubMed

    Silva, Francisco; Campello, Maria Paula C; Gano, Lurdes; Fernandes, Célia; Santos, Isabel C; Santos, Isabel; Ascenso, José R; João Ferreira, M; Paulo, António

    2015-02-21

    New N4O2-donor acyclic chelators 2-[[2-[2-(3,5-dimethylpyrazol-1-yl)ethyl-[2-[(2-hydroxyphenyl)methylamino]ethyl]amino]ethylamino]methyl]phenol (H2L(pz*,NH)) and 2-[[2-[2-[(2-hydroxyphenyl)methylamino]ethyl-(2-pyridylmethyl)amino]ethylamino]methyl]phenol (H2L(py,NH)) were obtained upon introduction of pyridyl or pyrazolyl coordinating units at the central nitrogen atom of diethylenetriamine (dien) and by functionalization of its terminal amines with phenol groups. The coordination behavior of H2L(pz*,NH) and H2L(py,NH) was evaluated towards (nat)Ga/(67)Ga, aiming to assess their suitability to obtain Ga(iii) chelates relevant for biomedical applications. Single crystal X-ray diffraction analysis of the complexes [GaL(pz*,NH)](ClO4) and [GaL(py,NH)](ClO4) confirmed the presence of N4O2-hexadentate chelators with the phenoxide groups coordinated cis relatively to the pyridyl/pyrazolyl arms. Unlike [GaL(pz*,NH)](ClO4), [GaL(py,NH)](ClO4) exists in solution as a mixture of isomers, as confirmed by several NMR techniques. The corresponding radiocomplex [(67)GaL(py,NH)](+) was obtained smoothly in almost quantitative radiochemical yield, contrary to [(67)GaL(pz*,NH)](+) that seems to be (hemi)labile under the same conditions. [(67)GaL(py,NH)](+) presents a high in vivo stability and a favourable biodistribution profile in mice. The imine congeners 2-[(E)-2-[2-(3,5-dimethylpyrazol-1-yl)ethyl-[2-[(E)-(2-hydroxyphenyl)methyleneamino]ethyl]amino]ethyliminomethyl]phenol (H2L(pz*,C[double bond, length as m-dash]N)) and 2-[(E)-2-[2-[(E)-(2-hydroxyphenyl)methyleneamino]ethyl-(2-pyridylmethyl)amino]ethyliminomethyl]phenol (H2L(py,C[double bond, length as m-dash]N)) were also evaluated but they did not form complexes compatible for biomedical applications owing to their high reactivity.

  18. Spectroscopic studies on two mono nuclear iron (III) complexes derived from a schiff base and an azodye

    SciTech Connect

    Mini, S. Sadasivan, V.; Meena, S. S. Bhatt, Pramod

    2014-10-15

    Two new mono nuclear Fe(III) complexes of an azodye (ANSN) and a Schiff base (FAHP) are reported. The azodye is prepared by coupling diazotized 1-amino-2-naphthol-4-sulphonicacid with 2-naphthol and the Schiff base is prepared by condensing 2-amino-3-hydroxy pyridine with furfural. The complexes were synthesized by the reaction of FeCl{sub 3}Ðœ‡2H{sub 2}O with respective ligands. They were characterized on the basis of elemental analysis and spectral studies like IR, NMR, Electronic and M.ssbauer. Magnetic susceptibility and Molar conductance of complexes at room temperature were studied. Based on the spectroscopic evidences and other analytical data the complexes are formulated as[Fe(ANSN)Cl(H{sub 2}O){sub 2}] and [Fe(FAHP)Cl{sub 2}(H{sub 2}O){sub 2}].

  19. Spectroscopic studies on two mono nuclear iron (III) complexes derived from a schiff base and an azodye

    NASA Astrophysics Data System (ADS)

    Mini, S.; Sadasivan, V.; Meena, S. S.; Bhatt, Pramod

    2014-10-01

    Two new mono nuclear Fe(III) complexes of an azodye (ANSN) and a Schiff base (FAHP) are reported. The azodye is prepared by coupling diazotized 1-amino-2-naphthol-4-sulphonicacid with 2-naphthol and the Schiff base is prepared by condensing 2-amino-3-hydroxy pyridine with furfural. The complexes were synthesized by the reaction of FeCl3˙2H2O with respective ligands. They were characterized on the basis of elemental analysis and spectral studies like IR, NMR, Electronic and M.ssbauer. Magnetic susceptibility and Molar conductance of complexes at room temperature were studied. Based on the spectroscopic evidences and other analytical data the complexes are formulated as[Fe(ANSN)Cl(H2O)2] and [Fe(FAHP)Cl2(H2O)2].

  20. Looking toward the Future: A Case Study of Open Source Software in the Humanities

    ERIC Educational Resources Information Center

    Quamen, Harvey

    2006-01-01

    In this article Harvey Quamen examines how the philosophy of open source software might be of particular benefit to humanities scholars in the near future--particularly for academic journals with limited financial resources. To this end he provides a case study in which he describes his use of open source technology (MySQL database software and…

  1. Exploring Open Distance Learning at a Jordanian University: A Case Study

    ERIC Educational Resources Information Center

    Dirani, Khalil M.; Yoon, Seung Won

    2009-01-01

    This case study explores an open distance learning program offered by the Information Technology and Computing (ITC) department at AOUJ, a major university in Jordan. It provides an overview of e-learning in the Arab region and explores factors that affect ODL quality in the Arab Open University in Jordan (AOUJ). The research utilized a…

  2. Extra-Curricular Social Studies in an Open Air History Museum

    ERIC Educational Resources Information Center

    Morris, Ronald Vaughan

    2008-01-01

    This article discusses extra-curricular social studies in an Open Air History Museum. Open Air History Museum, Conner Prairie Interpretive Park in Fishers, Indiana, is a cultural institution that encourages and supports talented students as they participate in an extra-curricular program. Ten-to sixteen-year-old youths "apply for jobs" as youth…

  3. NMR, DFT and luminescence studies of the complexation of Al(III) with 8-hydroxyquinoline-5-sulfonate.

    PubMed

    Ramos, M Luísa; Justino, Licínia L G; Salvador, Andreia I N; de Sousa, Andreia R E; Abreu, Paulo E; Fonseca, Sofia M; Burrows, Hugh D

    2012-10-28

    Multinuclear ((1)H, (13)C and (27)Al) magnetic resonance spectroscopy (1D and 2D), DFT calculations and fluorescence have been used to study the complexation of 8-hydroxyquinoline-5-sulfonate (8-HQS) with Al(III). The study combines the high sensitivity of luminescence techniques, the selectivity of multinuclear NMR spectroscopy with the structural details accessible through DFT calculations, and aims to provide a detailed understanding of the complexation between the Al(3+) ion and 8-HQS. A full speciation study has been performed and over the concentration region studied, the Al(3+) ion forms complexes with 8-HQS in an aqueous solution in the pH range 2-6. At higher pH, the extensive hydrolysis of the metal limits complexation. Using Job's method, three complexes were detected, with 1 : 1, 1 : 2 and 1 : 3 (metal : ligand) stoichiometries. These results are in agreement with those previously reported using potentiometric and electrochemical techniques. The geometries of the complexes are proposed based on the combination of NMR results with optimized DFT calculations. All the complexes in aqueous solutions at 25 °C are mononuclear species, and have an approximately octahedral geometry with the metal coordinated to one molecule of 8-HQS and four molecules of water (1 : 1 complex), two molecules of 8-HQS and two molecules of water mutually cis (1 : 2 complex), and to three molecules of 8-HQS in non-symmetrical arrangement (mer-isomer), for the 1 : 3 (metal : ligand) complex. On binding to Al(III), 8-HQS shows a more marked fluorescence than the weakly fluorescent free ligand. In addition, as previously noted, there are marked changes in the absorption spectra, which support the use of 8-HQS as a sensitive optical sensor to detect Al(3+) metal ions in surface waters and biological fluids. These complexes also show potential for applications in organic light emitting diodes (OLEDs).

  4. An immunohistochemical and serum ELISA study of type I and III procollagen aminopropeptides in primary biliary cirrhosis.

    PubMed Central

    Davis, B. H.; Madri, J. A.

    1987-01-01

    By means of ELISA methodology, the aminopropeptides of Type I and Type III procollagen were measured in the serum of a group of patients with primary biliary cirrhosis. The corresponding liver biopsies were graded blindly for degrees of fibrosis and inflammation. When available, paraffin-embedded liver specimens underwent immunoperoxidase staining for mature Type I and III collagen as well as the aminopropeptides of Type I and III procollagen. Regardless of the degree of fibrosis or inflammation, serum levels of the aminopropeptide of Type I remained within normal limits. In contrast, serum levels of the aminopropeptide of Type III procollagen were elevated uniformly. Immunohistochemistry demonstrated that the aminopropeptide of Type III procollagen persists extracellularly. This finding may explain the previously reported relationship between levels of inflammation and serum levels of the Type III aminopropeptide. Images Figure 7 Figure 8 PMID:3303951

  5. Zn-exchange and Mössbauer studies on the [Fe-Fe] derivatives of the purple acid Fe(III)-Zn(II)-phosphatase from kidney beans.

    PubMed

    Suerbaum, H; Körner, M; Witzel, H; Althaus, E; Mosel, B D; Müller-Warmuth, W

    1993-05-15

    In order to perform Mössbauer studies, Zn(II) in the Fe(III)-Zn(II) purple acid phosphatase of the red kidney bean has been exchanged by incubating the semiapoenzyme with 57Fe(II). The resulting Fe(III)-57Fe(II) enzyme has 125% activity, compared with that of the Zn(II) enzyme. It can be oxidized by H2O2 or peroxydisulfate to the Fe(III)-57Fe(III) species with a 30-times lower activity. Incubation of the metal-free apoenzyme with 57Fe(II) in the presence of O2 leads to the 57Fe(III)-57Fe(II) species which is stable in dilute solutions, but partially oxidized during the concentration procedure to the 57Fe(III)-57Fe(III) enzyme. Limited reduction of the oxidized enzyme with ascorbate delivers a mixture of the Fe(II)-Fe(II)/Fe(III)-Fe(III) species, but not the mixed valent Fe(III)-Fe(II) species, indicating that after the transfer of the first electron the second electron of the ascorbate radical is immediately transferred to the second Fe(III). The Mössbauer spectra of the oxidized species show at 4.2 K two quadrupole doublets with delta of 0.51 mm/s and 0.53 mm/s and delta E of 1.46 and 0.96 mm/s indicating high spin Fe(III) in two different binding sites, obviously with a higher asymmetry in the chromophoric Fe(III) site. The values are too low for a mu-oxo bridge. The mixed-valent Fe(III)-Fe(II) species shows two quadrupole doublets with delta values of 0.55 mm/s and 1.14 mm/s and delta E values of 1.43 mm/s and 3.01 mm/s at 70 K for high spin Fe(II) and Fe(III), but the signal of the Fe(II) component shows magnetic patterns at 4.2 K indicating a half-integer spin system with antiferromagnetic coupling. The Fe(II)-Fe(II) system exhibits two quadrupole doublets with delta values of 1.18 mm/s and 1.22 mm/s and with delta E values of 3.69 mm/s and 2.68 mm/s again indicating a higher asymmetry in the originally chromophoric Fe(III)-binding site. Addition of phosphate shows only minor differences in the oxidized enzyme and in the mixed valent Fe(III)-Fe(II) system

  6. Zn-exchange and Mössbauer studies on the [Fe-Fe] derivatives of the purple acid Fe(III)-Zn(II)-phosphatase from kidney beans.

    PubMed

    Suerbaum, H; Körner, M; Witzel, H; Althaus, E; Mosel, B D; Müller-Warmuth, W

    1993-05-15

    In order to perform Mössbauer studies, Zn(II) in the Fe(III)-Zn(II) purple acid phosphatase of the red kidney bean has been exchanged by incubating the semiapoenzyme with 57Fe(II). The resulting Fe(III)-57Fe(II) enzyme has 125% activity, compared with that of the Zn(II) enzyme. It can be oxidized by H2O2 or peroxydisulfate to the Fe(III)-57Fe(III) species with a 30-times lower activity. Incubation of the metal-free apoenzyme with 57Fe(II) in the presence of O2 leads to the 57Fe(III)-57Fe(II) species which is stable in dilute solutions, but partially oxidized during the concentration procedure to the 57Fe(III)-57Fe(III) enzyme. Limited reduction of the oxidized enzyme with ascorbate delivers a mixture of the Fe(II)-Fe(II)/Fe(III)-Fe(III) species, but not the mixed valent Fe(III)-Fe(II) species, indicating that after the transfer of the first electron the second electron of the ascorbate radical is immediately transferred to the second Fe(III). The Mössbauer spectra of the oxidized species show at 4.2 K two quadrupole doublets with delta of 0.51 mm/s and 0.53 mm/s and delta E of 1.46 and 0.96 mm/s indicating high spin Fe(III) in two different binding sites, obviously with a higher asymmetry in the chromophoric Fe(III) site. The values are too low for a mu-oxo bridge. The mixed-valent Fe(III)-Fe(II) species shows two quadrupole doublets with delta values of 0.55 mm/s and 1.14 mm/s and delta E values of 1.43 mm/s and 3.01 mm/s at 70 K for high spin Fe(II) and Fe(III), but the signal of the Fe(II) component shows magnetic patterns at 4.2 K indicating a half-integer spin system with antiferromagnetic coupling. The Fe(II)-Fe(II) system exhibits two quadrupole doublets with delta values of 1.18 mm/s and 1.22 mm/s and with delta E values of 3.69 mm/s and 2.68 mm/s again indicating a higher asymmetry in the originally chromophoric Fe(III)-binding site. Addition of phosphate shows only minor differences in the oxidized enzyme and in the mixed valent Fe(III)-Fe(II) system

  7. Study on the impact of device parameter variations on performance of III-V homojunction and heterojunction tunnel FETs

    NASA Astrophysics Data System (ADS)

    Hemmat, Maedeh; Kamal, Mehdi; Afzali-Kusha, Ali; Pedram, Massoud

    2016-10-01

    In this paper, the impact of physical parameter variations on the electrical characteristics of III-V TFETs is investigated. The study is performed on the operations of two optimized ultra-thin 20 nm double-gate transistors. The two device structures are InAs homojunction TFET and InAs-GaAs0.1Sb0.9 heterojunction TFET. The operation parameters are the ON-current, OFF-current, and threshold voltage. The investigation is performed at the device level, using a device simulator and the Monte-Carlo simulation approach is exploited to extract the distribution of electrical parameters in the presence of the process variation. The results reveal that the operation of the transistor is more sensitive to the doping of the source and gate work function compared to other physical parameters. Furthermore, the heterojunction TFETs show less sensitivity to physical parameter variations compared to the homojunction ones.

  8. Thermal decomposition of crystalline Ni(II)-Cr(III) layered double hydroxide: a structural study of the segregation process.

    PubMed

    Sileo, Elsa E; Jobbagy, Matías; Paiva-Santos, Carlos O; Regazzoni, Alberto E

    2005-05-26

    A structural study of the thermal evolution of Ni(0.69)Cr(0.31)(OH)(2)(CO(3))(0.155) x nH(2)O into NiO and tetragonal NiCr(2)O(4) is reported. The characteristic structural parameters of the two coexisting crystalline phases, as well as their relative abundance, were determined by Rietveld refinement of powder x-ray diffraction (PXRD) patterns. The results of the simulations allowed us to elucidate the mechanism of the demixing process of the oxides. It is demonstrated that nucleation of a metastable nickel chromite within the common oxygen framework of the parent Cr(III)-doped bunsenite is the initial step of the cationic redistribution. The role that trivalent cations play in the segregation of crystalline spinels is also discussed. PMID:16852228

  9. Ligational behavior of clioquinol antifungal drug towards Ag(I), Hg(II), Cr(III) and Fe(III) metal ions: Synthesis, spectroscopic, thermal, morphological and antimicrobial studies

    NASA Astrophysics Data System (ADS)

    El-Megharbel, Samy M.; Refat, Moamen S.

    2015-04-01

    This article presents a synthesis, characterization, theoretical and biological (anti-bacterial, and anti-fugal) evaluation studies of Ag(I), Hg(II), Cr(III) and Fe(III) complexes of clioquinol (CQ) drug ligand. Structures of the titled complexes cited herein were discussed using elemental analyses and spectral measurements e.g., IR, 1H NMR, and electronic studies. The results confirmed the formation of the clioquinol complexes by three molar ratios (1:1) for Ag(I), (1:2) for Hg(II) and (1:3) for both Cr(III) and Fe(III) metal ions. The clioquinol reacts as a bidentate chelate bound to all respected metal ions through the oxygen and nitrogen of quinoline-8-ol. The metal(II) ions coordinated to clioquinol ligand through deprotonation of sbnd OH terminal group. Infrared and 1H NMR spectral data confirm that coordination is via the oxygen of phenolic group and nitrogen atom of quinoline moiety. The molar conductance measurements of the CQ complexes in DMSO correspond to be non-electrolyte nature. Thus, these complexes may be formulated as [Ag(CQ)(H2O)2] H2O, [Hg(CQ)2]ṡ2H2O, [Cr(CQ)3] and [Fe(CQ)3]H2O. The Coats-Redfern method, the kinetic thermodynamic parameters like activation energies (E∗), entropies (ΔS∗), enthalpies (ΔH∗), and Gibbs free energies (ΔG∗) of the thermal decomposition reactions have been deduced from thermogravimetric curves (TG) with helpful of differential thermo gravimetric (DTG) curves. The narrow size distribution in nano-scale range for the clioquinol complexes have been discussed using X-ray powder diffraction (XRD), scanning electron microscope (SEM), and X-ray energy dispersive spectrometer (EDX) analyzer.

  10. The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection1[OPEN

    PubMed Central

    Shimono, Masaki; Porter, Katie; Kvitko, Brian H.; Henty-Ridilla, Jessica; Creason, Allison; Chang, Jeff H.; Staiger, Christopher J.

    2016-01-01

    The plant cytoskeleton underpins the function of a multitude of cellular mechanisms, including those associated with developmental- and stress-associated signaling processes. In recent years, the actin cytoskeleton has been demonstrated to play a key role in plant immune signaling, including a recent demonstration that pathogens target actin filaments to block plant defense and immunity. Herein, we quantified spatial changes in host actin filament organization after infection with Pseudomonas syringae pv. tomato DC3000 (Pst DC3000), demonstrating that the type-III effector HopG1 is required for pathogen-induced changes to actin filament architecture and host disease symptom development during infection. Using a suite of pathogen effector deletion constructs, coupled with high-resolution microscopy, we found that deletion of hopG1 from Pst DC3000 resulted in a reduction in actin bundling and a concomitant increase in the density of filament arrays in Arabidopsis, both of which correlate with host disease symptom development. As a mechanism underpinning this activity, we further show that the HopG1 effector interacts with an Arabidopsis mitochondrial-localized kinesin motor protein. Kinesin mutant plants show reduced disease symptoms after pathogen infection, which can be complemented by actin-modifying agents. In total, our results support a model in which HopG1 induces changes in the organization of the actin cytoskeleton as part of its virulence function in promoting disease symptom development. PMID:27217495

  11. Further studies of the turnover of dog antithrombin III. Study of /sup 131/I-labelled antithrombin protease complexes

    SciTech Connect

    Leonard, B.; Bies, R.; Carlson, T.; Reeve, E.B.

    1983-04-15

    Fresh plasma containing /sup 131/I-antithrombin III (*I-AT) was coagulated and incubated at 37 degrees C for 2 hr. A ''complex peak,'' separated on heparin-agarose contained AT and *I-AT antigen but no heparin cofactor activity. Crossed immunoelectrophoresis showed only AT complexes. SDS PAGE showed 80% of the *I-AT in a major band (approximately 80,000 daltons), 15% in a minor band (approximately 100,000 daltons) and the rest in trace bands (approximately 60,000 and/or 115,000 daltons). Ammonia treatment of the complex peak released alpha-thrombin. After i.v. injection 80% of the complexed *I-AT, chiefly as the major band, left the plasma with t 1/2 approximately 15 min and was almost immediately catabolized to low molecular weight breakdown products. A major catabolic site was the liver. A simple kinetic model describes the findings approximately.

  12. GTR treatment of degree III furcation defects with 2 different resorbable barriers. An experimental study in dogs.

    PubMed

    Araújo, M G; Berglundh, T; Lindhe, J

    1998-03-01

    The aim of the present study was to describe the periodontal tissue that formed after GTR when different resorbable barriers were applied to degree III furcation defects. The study was performed in 5 foxhound dogs. The 2nd and 4th premolars in both sides of the mandible were extracted. Degree III furcation defects were produced in the 3rd mandibular premolars. 5 weeks later, GTR therapy using a barrier composed by a polylactide-glycolide copolymer was performed on one quadrant (group A). In the contralateral quadrant, a barrier made of polylactide and citric acid ester (group B) was used. The dogs were sacrificed 6 months after reconstructive therapy. Tissue blocks containing the experimental teeth were excised, demineralised in EDTA and embedded in paraffin. Serial sections were cut in the mesio-distal plane and parallel with the long axis of the roots. The microtome was set at 7 microm. The sections were stained in hematoxyline and eosin. From each biopsy, 3 sections representing the central part of the furcation were selected for light microscopic examination. In the healed furcation sites, descriptive histological analysis and histomorphometric measurements of the newly formed tissues were performed. In both groups the root surface of the healed furcation defects was covered by a cellular, extrinsic-intrinsic fibers type cementum. The composition of the newly formed periodontal ligament was similar in both groups. The proportions of bone, bone marrow and periodontal ligament, however, were substantially larger in group A than in group B. In Group B, an area in the previous furcation defect was consistently occupied by a granuloma. It is suggested that the presence of the granuloma in the healed furcation defect prevented bone regrowth.

  13. A DEEP CHANDRA ACIS STUDY OF NGC 4151. III. THE LINE EMISSION AND SPECTRAL ANALYSIS OF THE IONIZATION CONE

    SciTech Connect

    Wang, Junfeng; Fabbiano, Giuseppina; Elvis, Martin; Risaliti, Guido; Karovska, Margarita; Zezas, Andreas; Mundell, Carole G.; Dumas, Gaelle; Schinnerer, Eva

    2011-11-20

    This paper is the third in a series in which we present deep Chandra ACIS-S imaging spectroscopy of the Seyfert 1 galaxy NGC 4151, devoted to study its complex circumnuclear X-ray emission. Emission features in the soft X-ray spectrum of the bright extended emission (L{sub 0.3-2{sub keV}} {approx} 10{sup 40} erg s{sup -1}) at r > 130 pc (2'') are consistent with blended brighter O VII, O VIII, and Ne IX lines seen in the Chandra HETGS and XMM-Newton RGS spectra below 2 keV. We construct emission line images of these features and find good morphological correlations with the narrow-line region clouds mapped in [O III] {lambda}5007. Self-consistent photoionization models provide good descriptions of the spectra of the large-scale emission, as well as resolved structures, supporting the dominant role of nuclear photoionization, although displacement of optical and X-ray features implies a more complex medium. Collisionally ionized emission is estimated to be {approx}<12% of the extended emission. Presence of both low- and high-ionization spectral components and extended emission in the X-ray image perpendicular to the bicone indicates leakage of nuclear ionization, likely filtered through warm absorbers, instead of being blocked by a continuous obscuring torus. The ratios of [O III]/soft X-ray flux are approximately constant ({approx}15) for the 1.5 kpc radius spanned by these measurements, indicating similar relative contributions from the low- and high-ionization gas phases at different radial distances from the nucleus. If the [O III] and X-ray emission arise from a single photoionized medium, this further implies an outflow with a wind-like density profile. Using spatially resolved X-ray features, we estimate that the mass outflow rate in NGC 4151 is {approx}2 M{sub Sun} yr{sup -1} at 130 pc and the kinematic power of the ionized outflow is 1.7 Multiplication-Sign 10{sup 41} erg s{sup -1}, approximately 0.3% of the bolometric luminosity of the active nucleus in

  14. Intravenous C.E.R.A. maintains stable haemoglobin levels in patients on dialysis previously treated with darbepoetin alfa: results from STRIATA, a randomized phase III study

    PubMed Central

    Canaud, Bernard; Mingardi, Giulio; Braun, Johann; Aljama, Pedro; Kerr, Peter G.; Locatelli, Francesco; Villa, Giuseppe; Van Vlem, Bruno; McMahon, Alan W.; Kerloëguen, Cécile; Beyer, Ulrich

    2008-01-01

    Background. Extending the administration interval of erythropoiesis-stimulating agents (ESAs) represents an opportunity to improve the efficiency of anaemia management in patients with chronic kidney disease (CKD). However, effective haemoglobin (Hb) maintenance can be challenging with epoetin alfa and epoetin beta administered at extended intervals. C.E.R.A., a continuous erythropoietin receptor activator, has a unique pharmacologic profile and long half-life (∼130 h), allowing administration at extended intervals. Phase III results have demonstrated that C.E.R.A. administered once every 4 weeks effectively maintains stable Hb levels in patients with CKD on dialysis. Methods. STRIATA (Stabilizing haemoglobin TaRgets in dialysis following IV C.E.R.A. Treatment for Anaemia) was a multicentre, open-label randomized phase III study to evaluate the efficacy and safety of intravenous C.E.R.A. administered once every 2 weeks (Q2W) for Hb maintenance following direct conversion from darbepoetin alfa (DA). Adult patients on dialysis receiving stable intravenous DA once weekly (QW) or Q2W were randomized (1:1) to continue their current DA regimen (n = 156) or receive intravenous C.E.R.A. Q2W (n = 157) for 52 weeks. Doses were adjusted to maintain Hb levels within ± 1.0 g/dl of baseline and between 10.0 and 13.5 g/dl. The primary endpoint was the mean Hb change between baseline and the evaluation period (weeks 29–36). Results. Most patients (>80%) received DA QW before randomization. The mean (95% CI) difference between C.E.R.A. and DA in the primary endpoint was 0.18 g/dl (−0.05, 0.41), within a pre-defined non-inferiority limit. C.E.R.A. was clinically non-inferior to DA (P < 0.0001) in maintaining Hb levels. Both treatments were well tolerated. Conclusions. Stable Hb levels were successfully maintained in patients on haemodialysis directly converted to Q2W intravenous C.E.R.A. from DA. PMID:18586762

  15. On Qualitative Differences in Learning: III--Study Skill and Learning

    ERIC Educational Resources Information Center

    Svensson, L.

    1977-01-01

    The intention in this research was to collect instances of study skill in different situations, and to relate study activity to levels of understanding and academic performance. Also reanalyzes data described by Marton and Saljo (1976a) which led to the concepts of deep-level processing and surface processing as explanations of qualitative…

  16. NEW EDUCATIONAL MEDIA IN ACTION--CASE STUDIES FOR PLANNERS--III.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    THIS IS A COLLECTION OF CASE STUDIES ON THE USE OF TELEVISION, RADIO, FILMSTRIPS, AND CORRESPONDENCE STUDY--ALONE, OR IN COMBINATION--FOR INSTRUCTION, EDUCATIONAL EXTENSION, AND ADULT EDUCATION IN SIX COUNTRIES--ITALY (ETV), NIGER (RADIO AND RADIO PLUS FILMSTRIPS), NEW ZEALAND (RADIO PLUS CORRESPONDENCE), HONDURAS (RADIO), NIGERIA (ETV), AND USA…

  17. An Exploratory Study of Women in the Health Professions Schools. Volume III: Women in Osteopathic Medicine.

    ERIC Educational Resources Information Center

    Urban and Rural Systems Associates, San Francisco, CA.

    As part of a larger study of the success and problems of women as applicants to and students in the schools of eight health professions, the study of osteopathic medicine involved interviews with administrators, faculty, and medical students. Its central purpose was to identify any characteristics of the profession--in its history, organization,…

  18. A Study of the WISC-III, CELF-R, Achievement, and Aptitude among Public School Students in Arkansas.

    ERIC Educational Resources Information Center

    Tannehill, Rhonda L.; Evans, Larry D.

    The relationship between the Wechsler Intelligence Scale for Children-III (WISC-III) and the Clinical Evaluation of Language Fundamentals-Revised (CELF-R) was investigated in 53 third graders from students in the 15 educational cooperatives across Arkansas. Additional information regarding race, academic achievement, and aptitude was gathered for…

  19. A Phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma

    PubMed Central

    Larkin, J M G; Hughes, S A; Beirne, D A; Patel, P M; Gibbens, I M; Bate, S C; Thomas, K; Eisen, T G; Gore, M E

    2006-01-01

    Temozolomide is an alkylating agent with activity in the treatment of melanoma metastatic to the brain. Lomustine is a nitrosurea that crosses the blood brain barrier and there is evidence to suggest that temozolomide may reverse resistance to lomustine. A multicentre phase I/II study was conducted to assess the maximum-tolerated dose (MTD), safety and efficacy of the combination of temozolomide and lomustine in melanoma metastatic to the brain. Increasing doses of temozolomide and lomustine were administered in phase I of the study to determine the MTD. Patients were treated at the MTD in phase II of the study to six cycles, disease progression or unacceptable toxicity. Twenty-six patients were enrolled in the study. In phase I of the study, the MTD was defined as temozolomide 150 mg m−2 days 1–5 every 28 days and lomustine 60 mg m–2 on day 5 every 56 days. Dose-limiting neutropaenia and thrombocytopaenia were observed at higher doses. Twenty patients were treated at this dose in phase II of the study. No responses to therapy were observed. Median survival from starting chemotherapy was 2 months. The combination of temozolomide and lomustine in patients with brain metastases from melanoma does not demonstrate activity. The further evaluation of this combination therefore is not warranted. PMID:17146474

  20. A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma.

    PubMed

    Larkin, J M G; Hughes, S A; Beirne, D A; Patel, P M; Gibbens, I M; Bate, S C; Thomas, K; Eisen, T G; Gore, M E

    2007-01-15

    Temozolomide is an alkylating agent with activity in the treatment of melanoma metastatic to the brain. Lomustine is a nitrosurea that crosses the blood brain barrier and there is evidence to suggest that temozolomide may reverse resistance to lomustine. A multicentre phase I/II study was conducted to assess the maximum-tolerated dose (MTD), safety and efficacy of the combination of temozolomide and lomustine in melanoma metastatic to the brain. Increasing doses of temozolomide and lomustine were administered in phase I of the study to determine the MTD. Patients were treated at the MTD in phase II of the study to six cycles, disease progression or unacceptable toxicity. Twenty-six patients were enrolled in the study. In phase I of the study, the MTD was defined as temozolomide 150 mg m(-2) days 1-5 every 28 days and lomustine 60 mg m(-2) on day 5 every 56 days. Dose-limiting neutropaenia and thrombocytopaenia were observed at higher doses. Twenty patients were treated at this dose in phase II of the study. No responses to therapy were observed. Median survival from starting chemotherapy was 2 months. The combination of temozolomide and lomustine in patients with brain metastases from melanoma does not demonstrate activity. The further evaluation of this combination therefore is not warranted. PMID:17146474

  1. A PSF-based approach to Kepler/K2 data - III. Search for exoplanets and variable stars within the open cluster M 67 (NGC 2682)

    NASA Astrophysics Data System (ADS)

    Nardiello, D.; Libralato, M.; Bedin, L. R.; Piotto, G.; Borsato, L.; Granata, V.; Malavolta, L.; Nascimbeni, V.

    2016-08-01

    In the third paper of this series we continue the exploitation of Kepler/K2 data in dense stellar fields using our PSF-based method. This work is focused on a ˜720-arcmin2 region centred on the Solar-metallicity and Solar-age open cluster M 67. We extracted light curves for all detectable sources in the Kepler channels 13 and 14, adopting our technique based on the usage of a high-angular-resolution input catalogue and target-neighbour subtraction. We detrended light curves for systematic errors, and searched for variables and exoplanets using several tools. We found 451 variables, of which 299 are new detection. Three planetary candidates were detected by our pipeline in this field. Raw and detrended light curves, catalogues, and K2 stacked images used in this work will be released to the community.

  2. Dolutegravir in Antiretroviral-Experienced Patients With Raltegravir- and/or Elvitegravir-Resistant HIV-1: 24-Week Results of the Phase III VIKING-3 Study

    PubMed Central

    Castagna, Antonella; Maggiolo, Franco; Penco, Giovanni; Wright, David; Mills, Anthony; Grossberg, Robert; Molina, Jean-Michel; Chas, Julie; Durant, Jacques; Moreno, Santiago; Doroana, Manuela; Ait-Khaled, Mounir; Huang, Jenny; Min, Sherene; Song, Ivy; Vavro, Cindy; Nichols, Garrett; Yeo, Jane M.; Aberg, J.; Akil, B.; Arribas, J. R.; Baril, J.-G.; Blanco Arévalo, J. L.; Blanco Quintana, F.; Blick, G.; Boix Martínez, V.; Bouchaud, O.; Branco, T.; Bredeek, U. F.; Castro Iglesias, M.; Clumeck, N.; Conway, B.; DeJesus, E.; Delassus, J.-L.; De Truchis, P.; Di Perri, G.; Di Pietro, M.; Duggan, J.; Duvivier, C.; Elion, R.; Eron, J.; Fish, D.; Gathe, J.; Haubrich, R.; Henderson, H.; Hicks, C.; Hocqueloux, L.; Hodder, S.; Hsiao, C.-B.; Katlama, C.; Kozal, M.; Kumar, P.; Lalla-Reddy, S.; Lazzarin, A.; Leoncini, F.; Llibre, J. M.; Mansinho, K.; Morlat, P.; Mounzer, K.; Murphy, M.; Newman, C.; Nguyen, T.; Nseir, B.; Philibert, P.; Pialoux, G.; Poizot-Martin, I.; Ramgopal, M.; Richmond, G.; Salmon Ceron, D.; Sax, P.; Scarsella, A.; Sension, M.; Shalit, P.; Sighinolfi, L.; Sloan, L.; Small, C.; Stein, D.; Tashima, K.; Tebas, P.; Torti, C.; Tribble, M.; Troisvallets, D.; Tsoukas, C.; Viciana Fernández, P.; Ward, D.; Wheeler, D.; Wilkin, T.; Yeni, G.-P.; Louise Martin-Carpenter, J.; Uhlenbrauck, Gina

    2014-01-01

    Background. The pilot phase IIb VIKING study suggested that dolutegravir (DTG), a human immunodeficiency virus (HIV) integrase inhibitor (INI), would be efficacious in INI-resistant patients at the 50 mg twice daily (BID) dose. Methods. VIKING-3 is a single-arm, open-label phase III study in which therapy-experienced adults with INI-resistant virus received DTG 50 mg BID while continuing their failing regimen (without raltegravir or elvitegravir) through day 7, after which the regimen was optimized with ≥1 fully active drug and DTG continued. The primary efficacy endpoints were the mean change from baseline in plasma HIV-1 RNA at day 8 and the proportion of subjects with HIV-1 RNA <50 c/mL at week 24. Results. Mean change in HIV-1 RNA at day 8 was −1.43 log10 c/mL, and 69% of subjects achieved <50 c/mL at week 24. Multivariate analyses demonstrated a strong association between baseline DTG susceptibility and response. Response was most reduced in subjects with Q148 + ≥2 resistance-associated mutations. DTG 50 mg BID had a low (3%) discontinuation rate due to adverse events, similar to INI-naive subjects receiving DTG 50 mg once daily. Conclusions. DTG 50 mg BID–based therapy was effective in this highly treatment-experienced population with INI-resistant virus. Clinical Trials Registration. www.clinicaltrials.gov (NCT01328041) and http://www.gsk-clinicalstudywww.gsk-clinicalstudyregister.com (112574). PMID:24446523

  3. Recent regulatory experience of low-Btu coal gasification. Volume III. Supporting case studies

    SciTech Connect

    Ackerman, E.; Hart, D.; Lethi, M.; Park, W.; Rifkin, S.

    1980-02-01

    The MITRE Corporation conducted a five-month study for the Office of Resource Applications in the Department of Energy on the regulatory requirements of low-Btu coal gasification. During this study, MITRE interviewed representatives of five current low-Btu coal gasification projects and regulatory agencies in five states. From these interviews, MITRE has sought the experience of current low-Btu coal gasification users in order to recommend actions to improve the regulatory process. This report is the third of three volumes. It contains the results of interviews conducted for each of the case studies. Volume 1 of the report contains the analysis of the case studies and recommendations to potential industrial users of low-Btu coal gasification. Volume 2 contains recommendations to regulatory agencies.

  4. Novel [99mTcIII(PS)2(Ln)] mixed-ligand compounds (PS = phosphino-thiolate; L = dithiocarbamate) useful in design and development of TcIII-based agents: synthesis, in vitro, and ex vivo biodistribution studies.

    PubMed

    Salvarese, Nicola; Morellato, Nicolò; Rosato, Antonio; Meléndez-Alafort, Laura; Refosco, Fiorenzo; Bolzati, Cristina

    2014-11-13

    A general procedure for the preparation of a new class of neutral six-coordinated mixed ligand [(99m)Tc(III)(PS)2(Ln)] compounds (PS = trisalkyl-phosphino-thiolate; Ln = dithiocarbamate) is reported as well as their in vitro stability and the ex vivo tissue distribution studies. [(99m)Tc(PS)2(Ln)] complexes were prepared in high yield in nearly physiologic conditions following a one-pot procedure. For instance, the chemical identity of [(99m)Tc(PSiso)2(L1)] (PSiso = 2-(diisopropylphosphino)ethanethiol; L1 = pyrrolidine dithiocarbamate) was determined by HPLC comparison with the corresponding (99g)Tc-complex. All complexes comprise the stable [(99m)Tc(III)(PS)2](+) moiety, where the remaining two coordination positions are saturated by a dithiocarbamate chelate, also carrying bioactive molecules (e.g., 2-methoxyphenylpiperazine). [(99m)Tc(PS)2(Ln)] complexes were inert toward ligand exchange reactions. No significant in vitro and in vivo biotransformation were observed, underlining their remarkable thermodynamic stability and kinetic inertness. These results could be conveniently utilized to devise a novel class of (99m)Tc(III)-based compounds useful in radiopharmaceutical applications. PMID:25333249

  5. The specific sorption of Np(V) on the corundum (α-Al2O3) surface in the presence of trivalent lanthanides Eu(III) and Gd(III): A batch sorption and XAS study.

    PubMed

    Virtanen, S; Bok, F; Ikeda-Ohno, A; Rossberg, A; Lützenkirchen, J; Rabung, T; Lehto, J; Huittinen, N

    2016-12-01

    The sorption of pentavalent neptunium, Np(V), on corundum (α-Al2O3) was investigated in the absence and presence of trivalent europium or gadolinium as a competing element under CO2-free conditions. The objective of this study was to investigate how a trivalent metal ion with a higher charge than that of the neptunyl(V) ion would affect the sorption of Np(V) when allowed to adsorb on the mineral surface before the addition of Np(V). Batch sorption experiments conducted as a function of pH (pH-edges) and as a function of Np(V) concentration (isotherms) in the absence and presence of 1×10(-5)M Eu(III) showed no sign of Eu being able to block Np sorption sites. Surface complexation modelling using the diffuse double layer model was applied to the batch data to obtain surface complexation constants for the formed Np(V) complexes on corundum. To account for potential changes occurring in the coordination environment of the neptunium ion in the presence of a trivalent lanthanide, X-ray absorption spectroscopy (XAS) measurements were carried out on the samples containing only Np(V) and Np(V)+Gd(III). The results reveal the presence of a bidentate Np(V) edge-sharing complex on the corundum surface in the absence of Gd(III), while the coordination environment of Np(V) on the corundum surface could be changed when Gd(III) is added to the sample before the sorption of Np(V).

  6. The specific sorption of Np(V) on the corundum (α-Al2O3) surface in the presence of trivalent lanthanides Eu(III) and Gd(III): A batch sorption and XAS study.

    PubMed

    Virtanen, S; Bok, F; Ikeda-Ohno, A; Rossberg, A; Lützenkirchen, J; Rabung, T; Lehto, J; Huittinen, N

    2016-12-01

    The sorption of pentavalent neptunium, Np(V), on corundum (α-Al2O3) was investigated in the absence and presence of trivalent europium or gadolinium as a competing element under CO2-free conditions. The objective of this study was to investigate how a trivalent metal ion with a higher charge than that of the neptunyl(V) ion would affect the sorption of Np(V) when allowed to adsorb on the mineral surface before the addition of Np(V). Batch sorption experiments conducted as a function of pH (pH-edges) and as a function of Np(V) concentration (isotherms) in the absence and presence of 1×10(-5)M Eu(III) showed no sign of Eu being able to block Np sorption sites. Surface complexation modelling using the diffuse double layer model was applied to the batch data to obtain surface complexation constants for the formed Np(V) complexes on corundum. To account for potential changes occurring in the coordination environment of the neptunium ion in the presence of a trivalent lanthanide, X-ray absorption spectroscopy (XAS) measurements were carried out on the samples containing only Np(V) and Np(V)+Gd(III). The results reveal the presence of a bidentate Np(V) edge-sharing complex on the corundum surface in the absence of Gd(III), while the coordination environment of Np(V) on the corundum surface could be changed when Gd(III) is added to the sample before the sorption of Np(V). PMID:27569516

  7. The Arabidopsis Class III Peroxidase AtPRX71 Negatively Regulates Growth under Physiological Conditions and in Response to Cell Wall Damage1[OPEN

    PubMed Central

    Raggi, Sara; Ranocha, Philippe

    2015-01-01

    The structure of the cell wall has a major impact on plant growth and development, and alteration of cell wall structural components is often detrimental to biomass production. However, the molecular mechanisms responsible for these negative effects are largely unknown. Arabidopsis (Arabidopsis thaliana) plants with altered pectin composition because of either the expression of the Aspergillus niger polygalacturonase II (AnPGII; 35S:AnPGII plants) or a mutation in the QUASIMODO2 (QUA2) gene that encodes a putative pectin methyltransferase (qua2-1 plants), display severe growth defects. Here, we show that expression of Arabidopsis PEROXIDASE71 (AtPRX71), encoding a class III peroxidase, strongly increases in 35S:AnPGII and qua2-1 plants as well as in response to treatments with the cellulose synthase inhibitor isoxaben, which also impairs cell wall integrity. Analysis of atprx71 loss-of-function mutants and plants overexpressing AtPRX71 indicates that this gene negatively influences Arabidopsis growth at different stages of development, likely limiting cell expansion. The atprx71-1 mutation partially suppresses the dwarf phenotype of qua2-1, suggesting that AtPRX71 contributes to the growth defects observed in plants undergoing cell wall damage. Furthermore, AtPRX71 seems to promote the production of reactive oxygen species in qua2-1 plants as well as plants treated with isoxaben. We propose that AtPRX71 contributes to strengthen cell walls, therefore restricting cell expansion, during normal growth and in response to cell wall damage. PMID:26468518

  8. Molecular structure of tetraaqua adenosine 5'-triphosphate aluminium(III) complex: a study involving Raman spectroscopy, theoretical DFT and potentiometry.

    PubMed

    Tenório, Thaís; Silva, Andréa M; Ramos, Joanna Maria; Buarque, Camilla D; Felcman, Judith

    2013-03-15

    The Alzheimer's disease is one of the most common neurodegenerative diseases that affect elderly population, due to the formation of β-amyloid protein aggregate and several symptoms, especially progressive cognitive decline. The result is a decrease in capture of glucose by cells leading to obliteration, meddling in the Krebs cycle, the principal biochemical route to the energy production leading to a decline in the levels of adenosine 5'-triphosphate. Aluminium(III) is connected to Alzheimer's and its ion provides raise fluidity of the plasma membrane, decrease cell viability and aggregation of amyloid plaques. Studies reveal that AlATP complex promotes the formation of reactive fibrils of β-amyloid protein and independent amyloidogenic peptides, suggesting the action of the complex as a chaperone in the role pathogenic process. In this research, one of complexes formed by Al(III) and adenosine 5'-triphosphate in aqueous solution is analyzed by potentiometry, Raman spectroscopy and ab initio calculations. The value of the logK(AlATP) found was 9.21±0.01 and adenosine 5'-triphosphate should act as a bidentate ligand in the complex. Raman spectroscopy and potentiometry indicate that donor atoms are the oxygen of the phosphate β and the oxygen of the phosphate γ, the terminal phosphates. Computational calculations using Density Functional Theory, with hybrid functions B3LYP and 6-311++G(d,p) basis set regarding water solvent effects, have confirmed the results. Frontier molecular orbitals, electrostatic potential contour surface, electrostatic potential mapped and Mulliken charges of the title molecule were also investigated.

  9. Molecular structure of tetraaqua adenosine 5'-triphosphate aluminium(III) complex: A study involving Raman spectroscopy, theoretical DFT and potentiometry

    NASA Astrophysics Data System (ADS)

    Tenório, Thaís; Silva, Andréa M.; Ramos, Joanna Maria; Buarque, Camilla D.; Felcman, Judith

    2013-03-01

    The Alzheimer's disease is one of the most common neurodegenerative diseases that affect elderly population, due to the formation of β-amyloid protein aggregate and several symptoms, especially progressive cognitive decline. The result is a decrease in capture of glucose by cells leading to obliteration, meddling in the Krebs cycle, the principal biochemical route to the energy production leading to a decline in the levels of adenosine 5'-triphosphate. Aluminium(III) is connected to Alzheimer's and its ion provides raise fluidity of the plasma membrane, decrease cell viability and aggregation of amyloid plaques. Studies reveal that AlATP complex promotes the formation of reactive fibrils of β-amyloid protein and independent amyloidogenic peptides, suggesting the action of the complex as a chaperone in the role pathogenic process. In this research, one of complexes formed by Al(III) and adenosine 5'-triphosphate in aqueous solution is analyzed by potentiometry, Raman spectroscopy and ab initio calculations. The value of the log KAlATP found was 9.21 ± 0.01 and adenosine 5'-triphosphate should act as a bidentate ligand in the complex. Raman spectroscopy and potentiometry indicate that donor atoms are the oxygen of the phosphate β and the oxygen of the phosphate γ, the terminal phosphates. Computational calculations using Density Functional Theory, with hybrid functions B3LYP and 6-311++G(d,p) basis set regarding water solvent effects, have confirmed the results. Frontier molecular orbitals, electrostatic potential contour surface, electrostatic potential mapped and Mulliken charges of the title molecule were also investigated.

  10. Epoetin alfa improves survival after chemoradiation for Stage III esophageal cancer: Final results of a prospective observational study

    SciTech Connect

    Rades, Dirk . E-mail: Rades.Dirk@gmx.net; Tribius, Silke; Yekebas, Emre F.; Bahrehmand, Roia; Wildfang, Ingeborg; Kilic, Ergin; Muellerleile, Ulrich; Gross, Eberhard; Schild, Steven E.; Alberti, Winfried

    2006-06-01

    Purpose: This prospective, nonrandomized study evaluates the effectiveness of epoetin alfa to maintain the hemoglobin levels at 12 to14 g/dL (optimal range for tumor oxygenation) during chemoradiation for Stage III esophageal cancer and its impact on overall survival (OS), metastatic-free survival (MFS), and locoregional control (LC). Methods and Materials: Ninety-six patients were included. Forty-two patients received epoetin alfa (150 IU/kg, 3 times a week) during radiotherapy, which was started at hemoglobin less than 13 g/dL and stopped at 14 g/dL or higher. Hemoglobin levels were measured weekly during RT. Results: Both groups were balanced for age, sex, performance status, tumor length/location, histology, grading, T-stage/N-stage, chemotherapy, treatment schedule, and hemoglobin before RT. Median change of hemoglobin was +0.3 g/dL/wk with epoetin alfa and -0.5 g/dL/wk without epoetin alfa. At least 60% of hemoglobin levels were 12 to 14 g/dL in 64% and 17% of the patients, respectively (p < 0.001). Patients who received epoetin alfa had better OS (32% vs. 8% at 2 years, p = 0.009) and LC (67% vs. 15% at 2 years, p = 0.001). MFS was not significantly different (42% vs. 18% at 2 years, p = 0.09). Conclusions: The findings suggest that epoetin alfa when used to maintain the hemoglobin levels at 12 to 14 g/dL can improve OS and LC of Stage III esophageal cancer patients.

  11. H I Studies of the Sculptor Group Galaxies. III - NGC 55

    NASA Astrophysics Data System (ADS)

    Puche, Daniel; Carignan, Claude; Wainscoat, Richard J.

    1995-07-01

    A VLA HI map was made of NGC 55. In this study, there is a continuum map (ngc0055.con), an HI data cube (ngc0055.cub), and moment maps (ngc0055.m0 = total HI, ngc0055.m1 = velocity field, and ngc0055.m2 = second moment). These maps have been used in an extensive dynamical and kinematical study of the Sculptor Group galaxies. The images and related TeX file come from the NRAO CDROM "Images From the Radio Universe" (c. 1992 National Radio Astronomy Observatory, used with permission).

  12. Environmental Education in Action - III: Case Studies of Public Involvement in Environmental Policy.

    ERIC Educational Resources Information Center

    Schoenfeld, Clay, Comp.; Desinger, John F., Comp.

    Presented here are 27 case studies of public involvement in environmental policy. These are examples of environmental education or communications programs developed by local, state, regional or national environmental action groups. The reports tell how the groups have successfully, or unsuccessfully, mobilized public opinion in favor of beneficent…

  13. Descriptive Study of Aircraft Hijacking. Criminal Justice Monograph, Volume III, No. 5.

    ERIC Educational Resources Information Center

    Turi, Robert R.; And Others

    The purpose of this study was to comprehensively describe all aspects of the phenomenon known as "skyjacking." The latest statistics on airline hijacking are included, which were obtained through written correspondence and personal interviews with Federal Aviation Authority officials in Washington, D. C. and Houston, Texas. Legal and technical…

  14. XAS studies of Ni(I), Ni(II), and Ni(III) complexes

    SciTech Connect

    Furenlid, L.R.; Renner, M.W.; Fujita, E.

    1995-01-01

    XAS techniques for studying structural and electronic changes taking place during oxidation and reduction reactions of nickel complexes are described and applied to selected models for Factor 430, a nickel containing cofactor catalyzing an important step in the conversion of carbon dioxide to methane by methanogenic bacteria.

  15. A comparative study of sorption of chromium (III) onto chitin and chitosan

    NASA Astrophysics Data System (ADS)

    Singh, Pooja; Nagendran, R.

    2016-06-01

    Heavy metals have always been the most hazardous components in the wastewater of industries like electroplating, automobiles, mining facilities and fertilizer manufacturers. Treatment of heavy metal laden wastewater requires expensive operational and maintenance systems. Food processing industries create a huge amount of shell waste which is sold to poultry farms in powdered form but the quantity thus used is still not comparable to the left over waste. The shell contains chitin which acts as an adsorbent for the heavy metals and can be used to treat heavy metal wastewater. The paper presents a study on the use of chitin and its processed product, chitosan, to remove chromium. Shake flask experiment was conducted to compare the adsorptive capacity of chitin and chitosan for chromium removal from simulated solution and isotherm studies were carried out. The studies showed that the chitosan was a better adsorbent than chitin. Both chitin and chitosan gave best adsorption results at pH 3. Chitin exhibited maximum chromium removal of 49.98 % in 20 min, whereas chitosan showed 50 % removal efficiency at a contact time of 20 min showing higher adsorptive capacity for chromium than chitin. The Langmiur and Freundlich isotherm studies showed very good adsorption capacity and monolayer interaction according to the regression coefficient 0.973 for chitosan and 0.915 for chitin. The regression coefficient for Freundlich isotherm was 0.894 and 0.831 for chitosan and chitin, respectively.

  16. Operation of Wastewater Treatment Plants: A Field Study Training Program. Volume III. Second Edition.

    ERIC Educational Resources Information Center

    California State Univ., Sacramento. Dept. of Civil Engineering.

    This manual was prepared by experienced wastewater collection system workers to provide a home study course to develop new qualified workers and expand the abilities of existing workers. This volume contains information on operational strategies for the activated sludge process and the use of pure oxygen, the handling and disposal of solids,…

  17. Report of "C" Testing. Beginning Teacher Evaluation Study. Technical Note Series. Technical Note III-4.

    ERIC Educational Resources Information Center

    Cahen, Leonard S.

    The "C" testing program, which followed the "A" and "B" tests of the Beginning Teacher Evaluation Study, is summarized. A sample of 139 second grade and 123 fifth grade students completed the reading and mathematics achievement battery, as well as affective scales regarding reading, mathematics, and school. The administration procedures, test…

  18. 76 FR 53704 - 30-Day Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... conduct monthly Passport Demand Forecasting Studies using multiple methodologies. Methodologies can.... The survey data will cover an estimated 48,000 respondents annually and will include variables covering passport, travel, and socio-demographic variables of interest to the Office of Passport...

  19. A Case Study of Technical Assistance to Demonstration Programs for Young Handicapped Children. Part III.

    ERIC Educational Resources Information Center

    Behr, Shirley K.; And Others

    The report describes the third and final year of a 3-year case study of the technical assistance process as implemented by the Technical Assistance Development System (TADS) for the staffs of two demonstration programs for preschool handicapped children and their families. Following a review of TADS and the two demonstration programs, the…

  20. III Annual Dade County Social Studies Fair. Profiles of Promise 3.

    ERIC Educational Resources Information Center

    Kleiman, Stanley; Haley, Frances

    In the one-day annual Fair, students from junior and senior high schools in Dade County participate in a variety of activities including displays, slide shows, plays, films, debates, and a college bowl competition. The events provide opportunities for students to demonstrate their knowledge and skills in the social studies and exchange ideas with…

  1. Phase III Program Study Report. Evaluation of the Child and Family Resource Program (CFRP).

    ERIC Educational Resources Information Center

    Johnson, Lynell; and Others

    Fourth in a series of Child and Family Resource Program (CFRP) evaluation reports, this document is devoted to the program study component, designed to illustrate CFRP operations across the country and to establish a descriptive context for statistical and analytic findings. Chapter 1 describes the process of building a network of linkages with…

  2. Reading Error Protocol Study: A Data Base. Volume III. Grades Three and Four.

    ERIC Educational Resources Information Center

    Simons, Herbert D.; Chambers, Richard

    This is the third of six volumes providing information drawn from a project designed to compile a substantial data base on reading errors for use by researchers and teachers. This volume contains transcriptions of oral reading error studies conducted with third and fourth grade students. The transcriptions are organized according to grade and…

  3. Seroprevalence and Risk Factors of Varicella Zoster Infection in Iranian Adolescents: A Multilevel Analysis; The CASPIAN-III Study.

    PubMed

    Hoseini, Shervin Ghaffari; Kelishadi, Roya; Kasaeian, Amir; Ataei, Behrooz; Yaran, Majid; Motlagh, Mohammad Esmaeil; Heshmat, Ramin; Ardalan, Gelayol; Safari, Omid; Qorbani, Mostafa; Mostafavi, Seyed Naseredin

    2016-01-01

    The objective of this study was to evaluate the varicella zoster virus (VZV) immunity in Iranian adolescents. It was conducted as a primary study for vaccine implementation, and to investigate the association of climatic and socioeconomic factors with the epidemiology of this infection. In this cross- sectional study, anti VZV antibodies were measured in serum samples obtained in a national school-based health survey (CASPIAN- III). Association of demographic, socio-economic, and climate of the living region with the frequency of VZV was investigated by multivariate multilevel analysis. Overall, sera of 2753 individuals aged 10-18 were tested for VZV antibodies, from those 87.4% were positive. The prevalence was statistically different in four socio-geographic regions (P<0.001), varying between 85.24% in West region (mostly mountainous areas with cold climate) to 94.59% in Southeast region (subtropical climate). Among variables studied, only age and mean daily temperature of the living area were positively associated with the VZV seroprevalence. Our findings show that most Iranians develop immunity to VZV before the age of 10, but a substantial proportion of them are yet susceptible to the infection. Therefore, it seems that the best strategy to reduce the burden of the disease is to vaccinate high- risk adults, i.e. those without a history of varicella infection. The regional temperature might be the only determinant of VZV epidemiology in Iran. PMID:27355931

  4. Seroprevalence and Risk Factors of Varicella Zoster Infection in Iranian Adolescents: A Multilevel Analysis; The CASPIAN-III Study

    PubMed Central

    Hoseini, Shervin Ghaffari; Kelishadi, Roya; Kasaeian, Amir; Ataei, Behrooz; Yaran, Majid; Motlagh, Mohammad Esmaeil; Heshmat, Ramin; Ardalan, Gelayol; Safari, Omid

    2016-01-01

    The objective of this study was to evaluate the varicella zoster virus (VZV) immunity in Iranian adolescents. It was conducted as a primary study for vaccine implementation, and to investigate the association of climatic and socioeconomic factors with the epidemiology of this infection. In this cross- sectional study, anti VZV antibodies were measured in serum samples obtained in a national school-based health survey (CASPIAN- III). Association of demographic, socio-economic, and climate of the living region with the frequency of VZV was investigated by multivariate multilevel analysis. Overall, sera of 2753 individuals aged 10–18 were tested for VZV antibodies, from those 87.4% were positive. The prevalence was statistically different in four socio-geographic regions (P<0.001), varying between 85.24% in West region (mostly mountainous areas with cold climate) to 94.59% in Southeast region (subtropical climate). Among variables studied, only age and mean daily temperature of the living area were positively associated with the VZV seroprevalence. Our findings show that most Iranians develop immunity to VZV before the age of 10, but a substantial proportion of them are yet susceptible to the infection. Therefore, it seems that the best strategy to reduce the burden of the disease is to vaccinate high- risk adults, i.e. those without a history of varicella infection. The regional temperature might be the only determinant of VZV epidemiology in Iran. PMID:27355931

  5. Mechanistic Studies of Reactions of Peroxodiiron(III) Intermediates in T201 Variants of Toluene/o-Xylene Monooxygenase Hydroxylase†

    PubMed Central

    Song, Woon Ju; Lippard, Stephen J.

    2011-01-01

    Site-directed mutagenesis studies of a strictly conserved T201 residue in the active site of toluene/o-xylene monooxygenase hydroxylase (ToMOH) revealed that a single mutation can facilitate kinetic isolation of two distinctive peroxodiiron(III) species, designated T201peroxo and ToMOHperoxo, during dioxygen activation. Previously we characterized both oxygenated intermediates by UV-vis and Mössbauer spectroscopy, proposed structures from DFT and QM/MM computational studies, and elucidated chemical steps involved in dioxygen activation through the kinetic studies of T201peroxo formation. In the current study, we investigated the kinetics of T201peroxo decay to explore the reaction mechanism of the oxygenated intermediates following O2 activation. The decay rates of T201peroxo were monitored in the absence and presence of external (phenol) or internal (tryptophan residue in an I100W variant) substrates under pre-steady-state conditions. Three possible reaction pathways were evaluated and the results demonstrate that T201peroxo is on the pathway of arene oxidation and appears to be in equilibrium with ToMOHperoxo. PMID:21595439

  6. Open-configuration MRI study of femoro-acetabular impingement.

    PubMed

    Yamamura, Mitsuyoshi; Miki, Hidenobu; Nakamura, Nobuo; Murai, Masakazu; Yoshikawa, Hideki; Sugano, Nobuhiko

    2007-12-01

    Femoro-acetabular impingement has been proposed as a causative factor of primary hip osteoarthritis. However, primary osteoarthritis of the hip is infrequent in Japan and other Asian countries, even though the hips of Asians frequently sustain impingement, since the Asian lifestyle commonly requires a larger range of hip motion than the Western lifestyle. Therefore, using open-configuration MRI, we investigated whether impingement actually occurs during some traditional Japanese hip positions. The hips of 5 healthy Japanese females were examined in 5 sitting postures: 1) sitting straight; 2) bowing while sitting straight; 3) sitting cross-legged; 4) W-sitting; and 5) squatting. The impingement point was detected by multiple plane reconstructed (MPR) views along with the acetabular rim depicted circumferentially. Impingement was considered to have occurred when, on MRI, the anterior femoral head-neck junction approached the acetabular rim and the femoral head was seen to float from the bottom of the acetabulum with the acetabular rim acting as a fulcrum. Impingement was observed in all volunteers in the W-sitting position, and in 2 of 5 volunteers during squatting. These findings show that impingement occurs frequently during daily Japanese activities. Thus, depending on race, femoro-acetabular impingement might not always cause primary osteoarthritis of the hip. (c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1582-1588, 2007. PMID:17600811

  7. A comprehensive study of the open cluster NGC 6866

    NASA Astrophysics Data System (ADS)

    Bostancı, Z. F.; Ak, T.; Yontan, T.; Bilir, S.; Güver, T.; Ak, S.; Çakırlı, Ö.; Özdarcan, O.; Paunzen, E.; De Cat, P.; Fu, J. N.; Zhang, Y.; Hou, Y.; Li, G.; Wang, Y.; Zhang, W.; Shi, J.; Wu, Y.

    2015-10-01

    We present CCD UBVRI photometry of the field of the open cluster NGC 6866. Structural parameters of the cluster are determined utilizing the stellar density profile of the stars in the field. We calculate the probabilities of the stars being physical members of the cluster, using their astrometric data, and perform further analyses using only the most probable members. The reddening and metallicity of the cluster were determined by independent methods. The LAMOST spectra and the ultraviolet excess of the F- and G-type main-sequence stars in the cluster indicate that the metallicity of the cluster is about the solar value. We estimated the reddening E(B - V) = 0.074 ± 0.050 mag using the U - B versus B - V two-colour diagram. The distance modula, the distance and the age of NGC 6866 were derived as μ = 10.60 ± 0.10 mag, d = 1189 ± 75 pc and t = 813 ± 50 Myr, respectively, by fitting colour-magnitude diagrams of the cluster with the PARSEC isochrones. The Galactic orbit of NGC 6866 indicates that the cluster is orbiting in a slightly eccentric orbit with e = 0.12. The mass function slope x = 1.35 ± 0.08 was derived by using the most probable members of the cluster.

  8. A study of explosively formed fuse (EFF) opening switch resistance

    SciTech Connect

    Oona, Henn; Goforth, James H; Herrera, Dennis H; Tasker, Douglas G; Torres, D. T.

    2010-12-21

    Many pulsed power experiments need pulse shaping to optimize the power flow from a flux compression generator (FCG) to an experimental load. In a laboratory environment this can be a simple task where the switches are not destroyed. However, in experiments with high explosives, where a large amount of damage occurs, a single use EFF opening switch may be a good choice. In an EFF, explosives are used to thin a current carrying sheet of aluminum as it is forced into a grooved dye. The current is modified by the time dependent changes in resistance as the aluminum is stretched. We will correlate the hydrodynamic effects with resistance. The hydrodynamic profile is determined by Mesa-2D, a well proven hydrodynamics computer code, and MA THEMA TICA is used convert material contours into total resistance using the resistivity as a function of time from various sources. Experimentally, we will determine the actual resistance and compare it with the calculated values. We have used these switches for decades but still do not understand the details of the physics. The resistance change may be due to several processes but in this paper we will concentrate on stretching as the most important contribution. Also, in this paper we will compare the details of the hydrodynamics with the details of experimental and calculated resistance and hopefully generate a predictive model for future designs with other geometries and materials.

  9. Accelerated sample processing, 1988-89, Phase III: Northeast cooperative woodstove study: Final report

    SciTech Connect

    Not Available

    1989-01-01

    The northeast cooperative woodstove study, conducted during the winter of 1988-89, measured particulate stack emissions using the AWES sampling system from 25 new-technology stoves installed in homes in the Glens Falls, N.Y. area. Five stove brands, 3 catalytic and 2 non-catalytic, were selected for the study based on their performance in a laboratory durability test. Each stove brand was represented by 5 stoves. The catalytic stoves were represented by the Blaze King Royal Heir, Country Flame BBF and the Oregon Woodstove. The non-catalytic stoves were the Country Comfort CC150 and the mid-size Regency. Each stove was sampled for 5 weekly periods spanning early January to late March. This type of sampling schedule provided an opportunity to document trends in stove emissions over the heating season as well as average performance.

  10. Comparative Studies on Plastoquinones. III. Distribution of Plastoquinones in Higher Plants 1

    PubMed Central

    Barr, Rita; Crane, F. L.

    1967-01-01

    The distribution of plastoquinones A 45, B and C was studied in representatives from 34 different plant families beginning with liverworts and mosses to higher plants. All of these species, including many monocots and dicots, contained significant amounts of the 3 quinones. Two species of Aesculus contained plastoquinone A 20 in addition to plastoquinone A 45, B, and C. Many dicots, such as Aesculus, watermelon, tobacco and tomato accumulated increasing quantities of plastoquinones A and C1-C4 during the growing season. The concentrations of plastoquinones B and C5-C6 tended to remain at a constant low level during the season (<0.01 μmole per mg chlorophyll). Preliminary studies with bean plants (Vicia faba and Phaseolus sp.) indicate that the levels of quinones varied little under different growth conditions (day length and temp.) although Vicia faba tended to have higher PQ A values with increased temperature. PMID:16656647

  11. Integrating epidemiology and epizootiology information in ecotoxicology studies. III. Ecosystem health

    SciTech Connect

    Schaeffer, D.J.; Novak, E.W.

    1988-12-01

    Epidemiology is the study of disease incidence rates in humans and epizootiology is the nonhuman animal equivalent. There have been few attempts to integrate epidemiological and epizootiological data from human and nonhuman animal populations coexisting in the same environment. The authors propose that epizootiology research be conducted on chemical pollutants using the framework of the natural environment as a laboratory. These kinds of studies are termed epizootiologic ecotoxicology. It is suggested that guilds, defined as a group of human individuals or a group of nonhuman species that use their environment in a similar way, be used as experimental probes to assess the effects of chemicals on ecosystems and humans. Improved data would increase the likelihood that effects in exposed populations will attain statistical significance so that high-risk populations can be detected while the number of affected individuals is low. Epizootiologic ecotoxicology information, the product of this research, must be treated as an important component of a unified health evaluation system.

  12. Overall efficacy and safety results of sofosbuvir-based therapies in phase II and III studies.

    PubMed

    Mangia, Alessandra; Piazzolla, Valeria

    2014-12-15

    The uridine nucleotide analogue sofosbuvir is a selective hepatitis C virus NS5B polymerase inhibitor, active regardless of genotype. We analyzed data on efficacy and safety of sofosbuvir, either in combination with pegylated interferon alfa-2a and ribavirin, or in combination with ribavirin alone as part of an interferon free regimen in more than 1300 patients. Treatment with sofosbuvir for 12 weeks in combination with P/R, in naïve genotype 1 patients was mainly studied in Neutrino. The efficacy of sofosbuvir as part of an all-oral combination including ribavirin alone, was explored in 555 naïve, ineligible and previous treatment failure genotype 2/3 patients. Rates of Sustained Viral Response in genotype 1 and 2 were higher than 85%. For genotype 3 and 4, a European study, Valence, and a US study on patients of Egyptian origin showed that naïve patients are cured at high rates by the all-oral combination given for 24 weeks. The efficacy of sofosbuvir plus P/R for 12 weeks in previous treatment failure genotype 3 has also been demonstrated. Sofosbuvir-based combinations are safe and well tolerated without side effects directly related to the drug. A large body of evidence suggests that sofosbuvir marks a revolution in HCV treatment.

  13. Theoretical study of time-resolved luminescence in semiconductors. III. Trap states in the band gap

    SciTech Connect

    Maiberg, Matthias Hölscher, Torsten; Zahedi-Azad, Setareh; Scheer, Roland

    2015-09-14

    In the third part of this series, we study the influence of trap states in the band gap of semiconductors on the time-resolved luminescence decay (TRL) after a pulsed excitation. The results based on simulations with Synopsys TCAD{sup ®} and analytical approximations are given for p-doped Cu(In,Ga)Se{sub 2} as a working example. We show that a single trap can be mostly described by two parameters which are assigned to minority carrier capture and emission. We analyze their influence on the luminescence decay and study the difference between a single trap and an energetic Gaussian trap distribution. It is found that trap states artificially increase the TRL decay and obscure the recombination dynamics. Thus, there is a demand for experimental methods which can reveal the recombination of minority carriers in a TRL experiment without trapping effect. In this regard, a variation of the device temperature, the excitation frequency, the injection level, as well as a bias illumination may be promising approaches. We study these methods, discuss advantages and disadvantages, and show experimental TRL for prove of concept. At the end, we validate our approach of simulating only band-to-band radiative recombination although photoluminescence spectra often exhibit free-to-bound radiative recombination of charge carriers.

  14. Armigeres subalbatus (Diptera: Culicidae) prophenoloxidase III is required for mosquito cuticle formation: ultrastructural study on dsRNA-knockdown mosquitoes.

    PubMed

    Tsao, I Y; Christensen, B M; Chen, C C

    2010-07-01

    We previously suggested that Armigeres subalbatus (Coquillett) prophenoloxidase III (As-pro-PO III) might be associated with morphogenesis of larvae and pupae. Because PO and its activation system are present in the insect cuticle, and cuticle formation is a major event during pupal morphogenesis, we used ultrastructural analysis to examine the effects of As-pro-PO III knockdown on the formation of pupal and adult cuticle. Inoculation of As-pro-PO III dsRNA resulted in the incomplete formation of nascent pupal endocuticle and pharate adult cuticle, i.e., significantly fewer cuticular lamellae were deposited, the helicoidal pattern of chitin microfibrils was disorganized, and numerous electron-lucent spaces were present in the cuticular protein matrix. Similar disruptions were observed in the cuticle of adults derived from As-pro-PO III dsRNA-inoculated pupae. It has long been suggested that the quinines, generated by PO-catalyzed oxidation reactions, function as cross-linking agents; therefore, it seems reasonable to suggest that the loss of As-pro-PO III-mediated protein-protein linkages causes morphological abnormalities in the protein matrix. Our findings suggest that As-pro-PO III plays a role in cuticle formation in mosquitoes, a novel function for phenol-oxidizing enzymes.

  15. Reduction in toxicity of arsenic(III) to Halobacillus sp. Y35 by kaolin and their related adsorption studies.

    PubMed

    Zhou, Yong; Yao, Jun; He, Minyan; Choi, Martin M F; Feng, Liang; Chen, Huilun; Wang, Fei; Chen, Ke; Zhuang, Rensheng; Maskow, Thomas; Wang, Gejiao; Zaray, Gyula

    2010-04-15

    The growth of Halobacillus sp. Y35 has been investigated in HGM hypersaline medium with different doses of As(III) and kaolin. The metabolic heat flux decreases with the increase in As(III) concentration, indicating that strain Y35 lowers their metabolic activity in order to resist the As(III) toxicity. Carbon dioxide flux, cell growth and protein synthesis rates, and total thermal effect have been, for the first time, successfully employed simultaneously to assess the effect of As(III) on strain Y35 in the absence and presence of kaolin. The relative adsorption capacity and adsorption intensity of kaolin for As(III) are higher with strain Y35 than that without strain Y35, demonstrating that it is possible to reduce the toxicity of As(III) to our environment by both using mineral adsorption and biosorption technology. Our work shows the potential application of kaolin and strain Y35 for the removal of As(III) from contaminated groundwater.

  16. A Study of Future Communications Concepts and Technologies for the National Airspace System-Part III

    NASA Technical Reports Server (NTRS)

    Ponchak, Denise S.; Apaza, Rafael D.; Wichgersm Joel M.; Haynes, Brian; Roy, Aloke

    2014-01-01

    The National Aeronautics and Space Administration (NASA) Glenn Research Center (GRC) is investigating current and anticipated wireless communications concepts and technologies that the National Airspace System (NAS) may need in the next 50 years. NASA has awarded three NASA Research Announcements (NAR) studies with the objective to determine the most promising candidate technologies for air-to-air and air-to-ground data exchange and analyze their suitability in a post-NextGen NAS environment. This paper will present progress made in the studies and describe the communications challenges and opportunities that have been identified as part of the study. NASA's NextGen Concepts and Technology Development (CTD) Project integrates solutions for a safe, efficient and high-capacity airspace system through joint research efforts and partnerships with other government agencies. The CTD Project is one of two within NASA's Airspace Systems Program and is managed by the NASA Ames Research Center. Research within the CTD Project is in support the 2011 NASA Strategic Plan Sub-Goal 4.1: Develop innovative solutions and advanced technologies, through a balanced research portfolio, to improve current and future air transportation. The focus of CTD is on developing capabilities in traffic flow management, dynamic airspace configuration, separation assurance, super density operations and airport surface operations. Important to its research is the development of human/automation information requirements and decisionmaking guidelines for human-human and human-machine airportal decision-making. Airborne separation, oceanic intrail climb/descent and interval management applications depend on location and intent information of surrounding aircraft. ADS-B has been proposed to provide the information exchange, but other candidates such as satellite-based receivers, broadband or airborne internet, and cellular communications are possible candidate's.

  17. Time Resolved Studies of Carrier Dynamics in III -v Heterojunction Semiconductors.

    NASA Astrophysics Data System (ADS)

    Westland, Duncan James

    Available from UMI in association with The British Library. Requires signed TDF. Picosecond time-resolution photoluminescence spectroscopy has been used to study transient processes in Ga _{.47}In_{.53 }As/InP multiple quantum wells (MQWs), and in bulk Ga_{.47}In _{.53}As and GaSb. To facilitate the experimental studies, apparatus was constructed to allow the detection of transient luminescence with 3ps time resolution. A frequency upconversion technique was employed. Relaxation of energetic carriers in bulk Ga _{.47}In_{.53 }As by optic phonons has been investigated, and, at carrier densities ~3 times 10^{18}cm ^{-3} is found to be a considerably slower process than simple theory predicts. The discrepancy is resolved by the inclusion of a non-equilibrium population of longitudinal optic phonons in the theoretical description. Slow energy loss is also observed in a 154A MQW under similar conditions, but carriers are found to relax more quickly in a 14A MQW with a comparable repeat period. The theory of non-equilibrium mode occupation is modified to describe the case of a MQW and is found to agree with experiment. Carrier relaxation in GaSb is studied and the importance of occupation of the L _6 conduction band valley in this material is demonstrated. The ambipolar diffusion of a photoexcited carrier plasma through an InP capping layer was investigated using an optical time-of-flight technique. This experiment also enables the efficiency of carrier capture by a Ga _{.47}In_{.53 }As quantum well to be determined. A capture time of 4ps was found.

  18. Electron diffraction studies of hot molecules. III. Stretching and bending anharmonicity in CF3Cl

    NASA Astrophysics Data System (ADS)

    Bartell, Lawrence S.; Vance, William; Goates, Steven R.

    1984-05-01

    Bond lengths, amplitudes of vibration, and asymmetries in distribution of nonbonded atom pairs were determined for CF3Cl at temperatures ranging from 300 to 1220 K. The CF but not the CCl bond length followed the commonly invoked approximation Δr=(3a/2)Δl2+ΔK+Δδr. The coefficients of skewness of nonbonded radial distribution peaks revealed substantial bending anharmonicity comparable to that detected in a previous study of binary fluorides and accounted for by the valence-shell-electron-pair repulsion force field in its points-on-a-sphere representation.

  19. Ellipsometric study of metal-organic chemically vapor deposited III-V semiconductor structures

    NASA Technical Reports Server (NTRS)

    Alterovitz, Samuel A.; Sekula-Moise, Patricia A.; Sieg, Robert M.; Drotos, Mark N.; Bogner, Nancy A.

    1992-01-01

    An ellipsometric study of MOCVD-grown layers of AlGaAs and InGaAs in thick films and strained layer complex structures is presented. It is concluded that the ternary composition of thick nonstrained layers can be accurately determined to within experimental errors using numerical algorithms. In the case of complex structures, thickness of all layers and the alloy composition of nonstrained layers can be determined simultaneously, provided that the correlations between parameters is no higher than 0.9.

  20. Post-mortem study of the hip joint. III. Correlations between observations.

    PubMed Central

    Byers, P D; Contepomi, C A; Farkas, T A

    1976-01-01

    Correlations between alterations in hip joints, described in a post-mortem study, have established the independence of limited and progressive alterations, and in addition have shown that there is a weak association between limited alterations and osteophytes and a strong one between progressive alterations and osteophytes. Nevertheless limited alterations may rarely undergo progressive damage. Cysts relate strongly to osteophytes but only moderately with progressive alterations. Limited alterations of both head and acetabulum can be subdivided. Some implications of these findings are discussed. PMID:942267

  1. Mössbauer effect study of iron(III) inidazolidine nitroxyl-free radical ligand complex

    NASA Astrophysics Data System (ADS)

    Mulaba, A.; Kiremire, E.; Pollak, H.; Boeyens, J.

    1999-09-01

    A new complex, [Fe(acac)L2], bearing inidazolidine nitroxyl-free radical ligand (L-) was recently synthesised for biological studies. It proved to be biologically active against African sleeping sickness, plasmodium falciparum (malaria), leishmaniasis and chaga disease causative agents. Three ESR well resolved peaks indicated the presence of a free (unpaired) and chemically active electron in the complex. The structural complex ferric iron was found at the centre of two electric gradient whose the biggest is suggested to be initiated by the unpaired charge. No distinction between different cis isomers could be made.

  2. A National Study of Internal Medicine--Phase III. Analysis of 1976-1977 Resident Cohort Currently in Practice. Final Report.

    ERIC Educational Resources Information Center

    Schleiter, Mary Kay; Tarlov, Alvin R.

    The different practice styles of young internists and the relationship between training and practice were studied as part of the National Study of Internal Medicine Manpower, Phase III. The practices of four groups of physicians were compared: general internists with traditional residencies, general internists who received their residency training…

  3. III-V tri-gate quantum well MOSFET: Quantum ballistic simulation study for 10 nm technology and beyond

    NASA Astrophysics Data System (ADS)

    Datta, Kanak; Khosru, Quazi D. M.

    2016-04-01

    In this work, quantum ballistic simulation study of a III-V tri-gate MOSFET has been presented. At the same time, effects of device parameter variation on ballistic, subthreshold and short channel performance is observed and presented. The ballistic simulation result has also been used to observe the electrostatic performance and Capacitance-Voltage characteristics of the device. With constant urge to keep in pace with Moore's law as well as aggressive scaling and device operation reaching near ballistic limit, a full quantum transport study at 10 nm gate length is necessary. Our simulation reveals an increase in device drain current with increasing channel cross-section. However short channel performance and subthreshold performance get degraded with channel cross-section increment. Increasing device cross-section lowers threshold voltage of the device. The effect of gate oxide thickness on ballistic device performance is also observed. Increase in top gate oxide thickness affects device performance only upto a certain value. The thickness of the top gate oxide however shows no apparent effect on device threshold voltage. The ballistic simulation study has been further used to extract ballistic injection velocity of the carrier and ballistic carrier mobility in the channel. The effect of device dimension and gate oxide thickness on ballistic velocity and effective carrier mobility is also presented.

  4. Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: A randomized placebo-controlled phase III study

    SciTech Connect

    Buentzel, Jens . E-mail: jens.buentzel@shk-ndh.de; Micke, Oliver; Adamietz, Irenaus A.; Monnier, Alain; Glatzel, Michael; Vries, Alexander de

    2006-03-01

    Purpose: Clinical trials demonstrated the efficacy and safety of intravenous (i.v.) or subcutaneous (s.c.) amifostine for reducing xerostomia and mucositis after radiotherapy or radiochemotherapy for head-and-neck cancer. This randomized, double-blinded, placebo-controlled, phase III study evaluated the efficacy and safety of i.v. amifostine during radiochemotherapy for head-and-neck cancer. Methods and Materials: Patients from European and American study centers received i.v. amifostine 300 mg/m{sup 2} (n = 67) or placebo (n = 65) before carboplatin 70 mg/m{sup 2} and radiotherapy on Days 1 to 5 and 21 to 25, and i.v. amifostine 200 mg/m{sup 2} or placebo before radiotherapy on other days. Results: Toxicity incidences were (amifostine, placebo, p value): Grade 2 or higher acute xerostomia (39%, 34%, 0.715), Grade 3 or higher acute mucositis (39%, 22%, 0.055), Grade 2 or higher late xerostomia (37%, 24%, 0.235), and Grade 3 or higher treatment-related adverse events (42%, 20%, 0.008). One-year rates of locoregional failure, progression-free survival, and overall survival were not significantly different between treatments. Conclusions: The used amifostine doses were not able to reduce the toxicity of simultaneous radiochemotherapy for head-and-neck cancer. The safety of amifostine and the lack of tumor protection were consistent with previous studies.

  5. Studies of interaction between terbium(III)-deferasirox and double helix DNA by spectral and electrochemical methods.

    PubMed

    Shaghaghi, Masoomeh; Dehghan, Gholamreza; Jouyban, Abolghasem; Sistani, Parisa; Arvin, Mitra

    2014-01-01

    DNA binding studies of terbium(III)-deferasirox (Tb3+-DFX) complex were monitored to understand the reaction mechanism and introduce a new probe for the assay of DNA. In the present work, UV absorption spectrophotometry, fluorescence spectroscopy, circular dichroism (CD), cyclic voltammetry (CV) and viscosity measurement were employed to study the interactions of Tb3+-DFX with calf thymus DNA (ctDNA). The binding of Tb3+-DFX complex to ctDNA showed a hyperchromic effect in the absorption spectra and the increase in fluorescence quenching effect (amount) of Tb3+-DFX complex in the presence of ctDNA. The binding constants (Kb) for the complex with ctDNA were estimated to be 1.8×10(4) M(-1) through UV absorption spectrophotometry and fluorescence spectroscopy. Upon addition of the complex, clear decreases were observed in the viscosity of ctDNA. The CD spectra indicated that there are certain detectable conformational changes in the DNA double helix when the complex was added. The CV method showed that both anodic and cathodic peak potentials of Tb3+-DFX complex showed negative shifts on the addition of the ctDNA. Further, competitive methylene blue binding studies with fluorescence spectroscopy have shown that the complex can bind to ctDNA through nonintercalative mode. The experimental results suggest that Tb3+-DFX complex binds to DNA via groove binding and/or electrostatic binding mode.

  6. Phase I/II study of trastuzumab, paclitaxel, cisplatin and radiation for locally advanced, HER2 overexpressing, esophageal adenocarcinoma

    SciTech Connect

    Safran, Howard . E-mail: hsafran@lifespan.org; Di Petrillo, Thomas; Akerman, Paul; Ng, Thomas; Evans, Devon; Steinhoff, Margaret; Benton, David; Purviance, John; Goldstein, Lisa; Tantravahi, Umadevi; Kennedy, Teresa R.N.

    2007-02-01

    Purpose: To determine the overall survival for patients with locally advanced, HER2 overexpressing, esophageal adenocarcinoma receiving trastuzumab, paclitaxel, cisplatin, and radiation on a Phase I-II study. Methods and Materials: Patients with adenocarcinoma of the esophagus without distant organ metastases and 2+/3+ HER2 overexpression by immunohistochemistry (IHC) were eligible. All patients received cisplatin 25 mg/m{sup 2} and paclitaxel 50 mg/m{sup 2} weekly for 6 weeks with radiation therapy (RT) 50.4 Gy. Patients received trastuzumab at dose levels of 1, 1.5, or 2 mg/kg weekly for 5 weeks after an initial bolus of 2, 3, or 4 mg/kg. Results: Nineteen patients were entered: 7 (37%) had celiac adenopathy, and 7 (37%) had retroperitoneal, portal adenopathy, or scalene adenopathy. Fourteen of 19 patients (74%) had either 3+ HER2 expression by immunohistochemistry, or an increase in HER2 gene copy number by HER2 gene amplification or high polysomy by fluorescence in situ hybridization. The median survival of all patients was 24 months and the 2-year survival was 50%. Conclusions: Assessment of the effect of trastuzumab in the treatment of patients with esophageal adenocarcinoma overexpressing HER2 is limited by the small number of patients in this study. Overall survival, however, was similar to prior studies without an increase in toxicity. Evaluation of HER2 status should be performed in future trials for patients with adenocarcinoma of the esophagus that investigate therapies targeting the HER family.

  7. NMR analyses of the cold cataract. III. /sup 13/C acrylamide studies

    SciTech Connect

    Lerman, S.; Megaw, J.M.; Moran, M.N.

    1985-10-01

    /sup 13/C-enriched acrylamide was employed to further delineate the action of this compound in preventing the cold cataract phenomenon when it is incorporated (in vitro) into young human and rabbit lenses. The extent of acrylamide incorporation, in the dark and with concurrent UV exposure, was monitored by /sup 13/C NMR spectroscopy. These studies provide further evidence that UV exposure causes permanent acrylamide photobinding within the lens. In such lenses, the gamma crystallin fraction of the soluble lens proteins is affected to the greatest extent. It appears to become aggregated and/or combined with the alpha and beta fractions resulting in an apparent loss of most of the gamma monomers. There is also an age-related effect with respect to the amount of acrylamide that can be incorporated into the lens. The decrease in acrylamide incorporation with age directly parallels the age-related decline in gamma crystallin levels.

  8. Agent neutralization studies III. Detoxification of VX in aqueous persulfate. Final report, May-August 1993

    SciTech Connect

    Hovanec, J.W.; Albizo, J.M.; Henderson, V.D.; Szafraniec, L.L.; Beaudry, W.T.

    1994-06-01

    Aqueous solutions of persulfate salts are frequently used to mineralize organic substrates in the course of total organic carbon analyses. A study has been conducted at the U.S. Army Edgewood Research, Development and Engineering Center to determine whether this approach may be useful to neutralize the nerve agent VX. VX was reacted with aqueous ammonium persulfate at 90 deg C and 70 deg C. The concentration of agent and the acidity of the mixture were varied. 31P-NMR was used to monitor the destruction of VX as well as the formation and degradation of the phosphorus-containing products. A titration procedure using ferrous sulfate and ceric ammonium nitrate was used to monitor the consumption of persulfate. The products formed and their stabilities were found to vary significantly with the acidity of the solution. Nuclear magnetic resonance, Oxidation, VX, Ammonium persulfate, Mineralization, Temperature effects, Chemical agent disposal.

  9. Computational Study of Formic Acid Dehydrogenation Catalyzed by Al(III)-Bis(imino)pyridine.

    PubMed

    Lu, Qian-Qian; Yu, Hai-Zhu; Fu, Yao

    2016-03-18

    The mechanism of formic acid dehydrogenation catalyzed by the bis(imino)pyridine-ligated aluminum hydride complex (PDI(2-))Al(THF)H (PDI=bis(imino)pyridine) was studied by density functional theory calculations. The overall transformation is composed of two stages: catalyst activation and the catalytic cycle. The catalyst activation begins with O-H bond cleavage of HCOOH promoted by aluminum-ligand cooperation, followed by HCOOH-assisted Al-H bond cleavage, and protonation of the imine carbon atom of the bis(imino)pyridine ligand. The resultant doubly protonated complex ((H,H) PDI)Al(OOCH)3 is the active catalyst for formic acid dehydrogenation. Given this, the catalytic cycle includes β-hydride elimination of ((H,H) PDI)Al(OOCH)3 to produce CO2, and the formed ((H,H) PDI)Al(OOCH)2 H mediates HCOOH to release H2. PMID:26879469

  10. MITR-III: Upgrade and relicensing studies for the MIT Research Reactor. Second annual report

    SciTech Connect

    Trosman, H.G.; Lanning, D.D.; Harling, O.K.

    1994-08-01

    The current operating license of the MIT research reactor will expire on May 7, 1996 or possibly a few years later if the US Nuclear Regulatory Commission agrees that the license period can start with the date of initial reactor operation. Driven by the imminent expiration of the operating license, a team of nuclear engineering staff and students have begun a study of the future options for the MIT Research Reactor. These options have included the range from a major rebuilding of the reactor to its decommissioning. This document reports the results of a two year intensive activity which has been supported by a $148,000 grant from the USDOE contract Number DEFG0293ER75859, approximately $100,000 of internal MIT funds and Nuclear Engineering Department graduate student fellowships as well as assistance from international visiting scientists and engineers.

  11. Phase I-II Study of Intraoperative Radiation Therapy (IORT) After Radical Prostatectomy for Prostate Cancer

    SciTech Connect

    Saracino, Biancamaria Gallucci, Michele; De Carli, Piero; Soriani, Antonella; Papalia, Rocco; Marzi, Simona; Landoni, Valeria; Petrongari, Maria Grazia; Arcangeli, Stefano; Forastiere, Ester; Sentinelli, Steno; Arcangeli, Giorgio

    2008-07-15

    Purpose: Recent studies have suggested an {alpha}/{beta} ratio in prostate cancer of 1.5-3 Gy, which is lower than that assumed for late-responsive normal tissues. Therefore the administration of a single, intraoperative dose of irradiation should represent a convenient irradiation modality in prostate cancer. Materials and Methods: Between February 2002 and June 2004, 34 patients with localized prostate cancer with only one risk factor (Gleason score {>=}7, Clinical Stage [cT] {>=}2c, or prostate-specific antigen [PSA] of 11-20 ng/mL) and without clinical evidence of lymph node metastases were treated with radical prostatectomy (RP) and intraoperative radiotherapy on the tumor bed. A dose-finding procedure based on the Fibonacci method was employed. Dose levels of 16, 18, and 20 Gy were selected, which are biologically equivalent to total doses of about 60-80 Gy administered with conventional fractionation, using an {alpha}/{beta} ratio value of 3. Results: At a median follow-up of 41 months, 24 (71%) patients were alive with an undetectable PSA value. No patients died from disease, whereas 2 patients died from other malignancies. Locoregional failures were detected in 3 (9%) patients, 2 in the prostate bed and 1 in the common iliac node chain outside the radiation field. A PSA rise without local or distant disease was observed in 7 (21%) cases. The overall 3-year biochemical progression-free survival rate was 77.3%. Conclusions: Our dose-finding study demonstrated the feasibility of intraoperative radiotherapy in prostate cancer also at the highest administered dose.

  12. HERschel Observations of Edge-on Spirals (HEROES). III. Dust energy balance study of IC 2531

    NASA Astrophysics Data System (ADS)

    Mosenkov, Aleksandr V.; Allaert, Flor; Baes, Maarten; Bianchi, Simone; Camps, Peter; De Geyter, Gert; De Looze, Ilse; Fritz, Jacopo; Gentile, Gianfranco; Hughes, Thomas M.; Lewis, Fraser; Verstappen, Joris; Verstocken, Sam; Viaene, Sébastien

    2016-07-01

    We investigate the dust energy balance for the edge-on galaxy IC 2531, one of the seven galaxies in the HEROES sample. We perform a state-of-the-art radiative transfer modelling based, for the first time, on a set of optical and near-infrared galaxy images. We show that by taking into account near-infrared imaging in the modelling significantly improves the constraints on the retrieved parameters of the dust content. We confirm the result from previous studies that including a young stellar population in the modelling is important to explain the observed stellar energy distribution. However, the discrepancy between the observed and modelled thermal emission at far-infrared wavelengths, the so-called dust energy balance problem, is still present: the model underestimates the observed fluxes by a factor of about two. We compare two different dust models, and find that dust parameters, and thus the spectral energy distribution in the infrared domain, are sensitive to the adopted dust model. In general, the THEMIS model reproduces the observed emission in the infrared wavelength domain better than the popular BARE-GR-S model. Our study of IC 2531 is a pilot case for detailed and uniform radiative transfer modelling of the entire HEROES sample, which will shed more light on the strength and origins of the dust energy balance problem. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.The reduced images (as FITS files) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A71

  13. Regional Disparities in Sedentary Behaviors and Meal Frequency in Iranian Adolescents: The CASPIAN-III Study

    PubMed Central

    Baygi, Fereshteh; Heshmat, Ramin; Kelishadi, Roya; Mohammadi, Fatemeh; Motlagh, Mohammad Esmail; Ardalan, Gelayol; Asayesh, Hamid; Larijani, Bagher; Qorbani, Mostafa

    2015-01-01

    Background: The prevalence of obesity is increasing among Iranian youngsters like other developing countries. Objectives: This study was conducted to assess regional disparities in sedentary behaviors and meal frequency in Iranian adolescents. Patients and Methods: In this national survey, 5682 students aged 10 - 18 years from urban and rural districts of 27 provinces of Iran were selected via stratified multi-stage sampling method. The country was classified into four sub-national regions, based on criteria of the combination of geography and socioeconomic status (SES). Mean of meal frequency and physical activity levels as well as prevalence of omitting meals and sedentary behavior were compared across regions with different SES after stratifying with sex and age group. Results: Meal frequency in lower socio-economic regions was significantly higher than two other regions in 10 - 13 and 10 - 18 years old groups (P trend < 0.001). However, the mean of working hours with computer was linearly increased with increasing the SES in studied regions (P trend < 0.001), whereas the corresponding figure was not significant for the mean of watching TV (P trend > 0.05). Frequency of adolescents omitting their meals was higher in higher SES regions especially in West Iran (P < 0.001) in 10 - 13 years old age group. Having personal computer and working with it more than two hours per day mainly was observed in central Iran which ranked as the highest SES group. Conclusions: Efforts to ensure Iranian youth meet healthy food habits and screen time guidelines include limiting access to screen technologies and encouraging parents to monitor their own screen time is required. PMID:26195993

  14. A new negroid-specific HindIII polymorphism in the serum amyloid A1 (SAA1) gene increases the usefulness of the SAA locus in linkage studies

    SciTech Connect

    Stevens, G.; Ramsay, M.; Jenkins, T. ); Kluve-Beckerman, B. )

    1993-01-01

    The cDNA probe pSAA82 detects three serum amyloid A (SAA) loci on chromosome 11p. SAA1 and SAA2 have 90% nucleotide identity in exon and intron sequences (1), whereas SAA3 has an average of 70% identity with SAA1 and SAA2 (3). The chromosomal organization of the loci is not yet known. A two-allele polymorphic HindIII site was found within intron 2 of the SAA2 locus (1) with fragments of 3.0 (a2) and 5.0 kb (a1) (previously sized as 2.8 and 4.6 kb, respectively) which occur in Caucasoids, Negroids, and San (formerly [open quote]Bushmen[close quotes]) (2). The discovery of a further, Negroid-specific, polymorphic HindIII restriction site, detected with the same probe, increases its usefulness. This RFLP is associated with the SAA1 locus (6) and is characterized by the presence of two allelic fragments of 3.6 (b1) and 1.4 kb (b2). This HindIII site is also thought to occur within intron 2 because of the strong evolutionary conservation between the SAA1 and SAA2 genes. The polymorphism may therefore either predate the gene duplication event or be present as a result of gene conversion. 6 refs., 1 fig.

  15. Hydrologic studies in wells open through large intervals. Annual report, 1992

    SciTech Connect

    Not Available

    1992-12-31

    This report describes and summarizes activities, data, and preliminary data interpretation from the INEL Oversight Program R&D-1 project titled ``Hydrologic Studies In Wells Open Through Large Intervals.`` The project is designed to use a straddle-packer system to isolate, hydraulically test, and sample specific intervals of monitoring wells that are open (uncased, unscreened) over large intervals of the Snake River Plain aquifer. The objectives of the project are to determine and compare vertical variations in water quality and aquifer properties that have previously only been determined in an integrated fashion over the entire thickness of the open interval of the observation wells.

  16. Electroanalytical and isothermal calorimetric study of As(III) complexation by the metal poisoning remediators, 2,3-dimercapto-1-propanesulfonate and meso-2,3-dimercaptosuccinic acid.

    PubMed

    Cavanillas, Santiago; Chekmeneva, Elena; Ariño, Cristina; Díaz-Cruz, José Manuel; Esteban, Miquel

    2012-10-01

    A recently developed methodology, which combines voltammetry, ITC, ESI-MS and several chemometric tools, has been applied for the first time to the study of As(III) complexes. The ligands considered, DMSA and DMPS, are commonly used to treat heavy metal poisoning. The study yields a reliable and consistent picture of the binding of As(III) by the chelating therapy agents DMSA and DMPS providing an unambiguous description of the stoichiometries of the complexes (ML(2), with the occasional appearance of ML in the case of DMSA), both ligands have stability constants of the same order, with a logβ(2) of 9.2 and 9.8, respectively. These values confirm the potential efficiency of both ligands in the treatment of As(III) poisoning.

  17. Physiological Studies of Glutamine Synthetases I and III from Synechococcus sp. WH7803 Reveal Differential Regulation.

    PubMed

    Domínguez-Martín, María Agustina; Díez, Jesús; García-Fernández, José M

    2016-01-01

    The marine picocyanobacterium Synechococcus sp. WH7803 possesses two glutamine synthetases (GSs; EC 6.3.1.2), GSI encoded by glnA and GSIII encoded by glnN. This is the first work addressing the physiological regulation of both enzymes in a marine cyanobacterial strain. The increase of GS activity upon nitrogen starvation was similar to that found in other model cyanobacteria. However, an unusual response was found when cells were grown under darkness: the GS activity was unaffected, reflecting adaptation to the environment where they thrive. On the other hand, we found that GSIII did not respond to nitrogen availability, in sharp contrast with the results observed for this enzyme in other cyanobacteria thus far studied. These features suggest that GS activities in Synechococcus sp. WH7803 represent an intermediate step in the evolution of cyanobacteria, in a process of regulatory streamlining where GSI lost the regulation by light, while GSIII lost its responsiveness to nitrogen. This is in good agreement with the phylogeny of Synechococcus sp. WH7803 in the context of the marine cyanobacterial radiation. PMID:27446010

  18. Comparative study of two layered lanthanide dicarboxylates based on europium(III) dimers

    NASA Astrophysics Data System (ADS)

    Surblé, Suzy; Serre, Christian; Millange, Franck; Pellé, Fabienne; Férey, Gérard

    2007-02-01

    The new rare-earth dicarboxylate solid Eu 2(H 2O) 4{C 6H 10-(CO 2) 2} 3·2H 2O or MIL-94 has been isolated under hydrothermal conditions. Its layered structure, which was solved using X-ray powder diffraction data, is built up from dimers of nine-coordinated edge-sharing polyhedra linked through 1,3-cyclohexane dicarboxylate (1,3-CHC) moieties. A comparative study of MIL-94 and the layered lanthanide dicarboxylate EuBDC or Eu 2(H 2O) 2{C 6H 4-(CO 2) 2} 3, which is built up from dimers of corner-sharing polyhedra and 1,3-benzenedicarboxylate (1,3-BDC) linkers, is also reported. Crystal data for MIL-94: orthorhombic space group Pnma (no. 62) with a = 8.8470(1) Å, b = 25.0148(1) Å, c = 14.3716(4) Å and Z = 4. MIL stands for Material Institut Lavoisier.

  19. Equine laryngeal hemiplegia. Part III. A teased fibre study of peripheral nerves.

    PubMed

    Cahill, J I; Goulden, B E

    1986-11-01

    Individual nerve fibres were isolated from the recurrent laryngeal and some distal hindlimb nerves, in an investigation of equine laryngeal hemiplegia. One hundred teased fibres were obtained from each of three sampling sites on both left and right recurrent laryngeal nerves, from 15 Thoroughbred horses. These fibres were graded descriptively and internode lengths measured. A distal distribution of pathology was demonstrated in all groups studied, but was most severe in the clinical group of horses. The predominant change was one of short thinly myelinated internodes interspersed amongst normally myelinated internodes, indicating remyelination of previously demyelinated areas of nerve fibre. Such pathological change was also reflected by the decreased mean internode length, and its increased variability associated with disease. However, it was determined statistically that these abnormal internodes were grouped along particular nerve fibres, rather than being randomly distributed between all nerve fibres. This is thought to indicate myelin sheath changes secondary to underlying axonal pathology. Thus it was concluded that the primary pathology was likely to be axonal in nature, while the high incidence of demyelination changes was a reflection of the chronic nature of the disease process. Thus, the distal distribution of pathology, the primary axonal involvement, the presence of changes in left and right recurrent laryngeal and distal limb nerves, all support the classification of equine laryngeal hemiplegia as a distal axonopathy.

  20. Studies on the livestock of southern Darfur, Sudan. III. Production traits in sheep.

    PubMed

    Wilson, R T

    1976-05-01

    The results of an intensive 15 months' study of 10 flocks of indigenous sheep are recorded. Lambing rates approach 1.5 lambs per ewe per year, but a death rate of 23 per cent and an offtake of 27 per cent, means that flock numbers are probably slightly declining. Twins account for 14 per cent of all births but the death rate of twin lambs is almost twice that of single lambs up to 6 months of age. Increased productivity is therefore more likely to be achieved by improving the survival and growth rates of single lambs than by selection for twinning. The weighted average rate of lightweight gain for all surviving lambs is 82 g per day up to 1 year of age, and is better than that recorded for any other indigenous African sheep. Meat production per kg of breeding female, at 0.253 kg up to 6 months of age of the young, is almost six times the production of cattle under the same management and environmental conditions, but is inferior to that of goats.

  1. Spectroscopic studies of Wolf-Rayet stars. III - The WC subclass

    NASA Technical Reports Server (NTRS)

    Torres, A. V.; Conti, P. S.; Massey, P.

    1986-01-01

    Wolf-Rayet (W-R) stars, which are the descendants of massive O-type stars, can be subdivided into three groups depending on their spectral appearance. These groups include the nitrogen class (WN), the carbon class (WC), and the oxygen class (WO). The present paper is concerned with the WC stars. The assignment of WC subtypes has been based on visual inspections of photographic plates. One of the aims of this study is related to the quantification of the visual estimates. The measured ratios of equivalent widths and the FWHM of the 4650 A line for Galactic and LMC stars are presented, and the reclassification of some stars is proposed on this basis. In particular, it is shown that the majority of the LMC WC stars should logically be classified WC4 instead of WC5. Comments on individual stars are provided, and terminal velocities are discussed. It is attempted to give a complete overview of the most important spectroscopic features of the WC stars in the optical region.

  2. Physiological Studies of Glutamine Synthetases I and III from Synechococcus sp. WH7803 Reveal Differential Regulation

    PubMed Central

    Domínguez-Martín, María Agustina; Díez, Jesús; García-Fernández, José M.

    2016-01-01

    The marine picocyanobacterium Synechococcus sp. WH7803 possesses two glutamine synthetases (GSs; EC 6.3.1.2), GSI encoded by glnA and GSIII encoded by glnN. This is the first work addressing the physiological regulation of both enzymes in a marine cyanobacterial strain. The increase of GS activity upon nitrogen starvation was similar to that found in other model cyanobacteria. However, an unusual response was found when cells were grown under darkness: the GS activity was unaffected, reflecting adaptation to the environment where they thrive. On the other hand, we found that GSIII did not respond to nitrogen availability, in sharp contrast with the results observed for this enzyme in other cyanobacteria thus far studied. These features suggest that GS activities in Synechococcus sp. WH7803 represent an intermediate step in the evolution of cyanobacteria, in a process of regulatory streamlining where GSI lost the regulation by light, while GSIII lost its responsiveness to nitrogen. This is in good agreement with the phylogeny of Synechococcus sp. WH7803 in the context of the marine cyanobacterial radiation. PMID:27446010

  3. Confirmation of model-based dose selection for a Japanese phase III study of rivaroxaban in non-valvular atrial fibrillation patients.

    PubMed

    Kaneko, Masato; Tanigawa, Takahiko; Hashizume, Kensei; Kajikawa, Mariko; Tajiri, Masahiro; Mueck, Wolfgang

    2013-01-01

    This study was designed to confirm the appropriateness of the dose setting for a Japanese phase III study of rivaroxaban in patients with non-valvular atrial fibrillation (NVAF), which had been based on model simulation employing phase II study data. The previously developed mixed-effects pharmacokinetic/pharmacodynamic (PK-PD) model, which consisted of an oral one-compartment model parameterized in terms of clearance, volume and a first-order absorption rate, was rebuilt and optimized using the data for 597 subjects from the Japanese phase III study, J-ROCKET AF. A mixed-effects modeling technique in NONMEM was used to quantify both unexplained inter-individual variability and inter-occasion variability, which are random effect parameters. The final PK and PK-PD models were evaluated to identify influential covariates. The empirical Bayes estimates of AUC and C(max) from the final PK model were consistent with the simulated results from the Japanese phase II study. There was no clear relationship between individual estimated exposures and safety-related events, and the estimated exposure levels were consistent with the global phase III data. Therefore, it was concluded that the dose selected for the phase III study with Japanese NVAF patients by means of model simulation employing phase II study data had been appropriate from the PK-PD perspective. PMID:23337693

  4. Photochemistry of iron(III)-carboxylato complexes in aqueous atmospheric particles - Laboratory experiments and modeling studies

    NASA Astrophysics Data System (ADS)

    Weller, C.; Tilgner, A.; Herrmann, H.

    2010-12-01

    , glutarate and gluconate complexes lie in the range of 0.02 < Φ < 0.10, whereas succinate, tartronate, pyruvate and glyoxalate systems have values between 0.16 < Φ < 1.26. All quantum yields include contributions from secondary thermal reactions. Furthermore, an attempt was made to differentiate between contributions of individual iron-oxalato complexes to the overall measured quantum yield. The formation and photolysis of the iron-carboxylate complexes and the subsequent reactions of the resulting compounds have been implemented in CAPRAM 3.0 (Chemical Aqueous Phase Radical Mechanism). Modeling studies were performed to investigate the effects of the expanded iron photochemistry on oxidant budgets, the iron redox-cycling and the processing of secondary organic acids in cloud droplets and deliquescent particles under different environmental conditions. The model studies have shown that, i.e. for pyruvic acid under urban conditions, the photolysis of the iron-pyruvate complex can contribute with about 40 % significantly to the overall degradation flux and represents thus an important loss pathway beside the radical oxidation pathways.

  5. Ceramicrete{trademark} Stabilization of CST Resin: ITP Alternative Phase III Feasibility Study

    SciTech Connect

    Langton, C A

    1998-12-07

    The Ceramicrete{trademark} waste form is a magnesium phosphate hydrate, which sets as the result of an acid-base reaction between KH{sub 2}PO{sub 4} and MgO in the presence of water. Based on the results of this feasibility study, this low temperature ceramic waste form is acceptable for stabilization of cesium loaded crystalline silicotitanate (CST) resin. The performance objective of CST stabilization is to convert a friable powdered resin into a monolithic form to improve handling and storage and to reduce the waste mobility. Advantages of this type of the CST-Ceramicrete{trademark} waste form include: room temperature processing of a fluid slurry, limited off gas, flexible mix designs, rapid setting, no free liquids, temperature tolerant and durable up to at least 90 degrees C. The Ceramicrete/220 waste form can be processed by in-container mixing or by batch mixing. Since a trace amount of free water will be associated with the wet resin in the CST-Ceramicrete{trademark} waste form, radiolysis of the free water may cause pressurization of the containers. Leaching tests were conducted to evaluate the CST-Ceramicrete{trademark} waste form performance relative to high-level waste glass. Results were very encouraging given that only one waste loading (50 wt. percent resin) was tested and that the leaching procedures were not fully optimized for a non-glass waste form. In general, the cesium leachability per the PCT test of the CST-Ceramicrete{trademark} waste was about 2X more than that of the ARM glass and about 200X more than the EA glass. For monolithic samples (MCC-1 test), the CST-Ceramicrete{trademark} waste form leached 4X to7X more cesium than the ARM glass. (The EA glass is not suited to monolithic leaching.) The CST-Ceramicrete{trademark} leaching results appear to be independent of curing temperature over the range 24 to 90 degrees C.

  6. Studies of Accreting Neutron Stars with RXTE Cycle 4 Observations: III: TOO Observations of Atoll Sources

    NASA Technical Reports Server (NTRS)

    Paciesas, William S.

    2002-01-01

    NASA Grant NAG 5-9244 provided funds for the research projects 'ASM-Triggered TOO Observations of Kilohertz Oscillations in Five Atoll Sources' and 'Further Measurements of the Kilohertz Oscillations in 4U 1705-44' approved under the Rossi X-ray Timing Explorer (RXTE) Guest Observer Program Cycle 4 and funded under the 1999 NASA Astrophysics Data Program. The principal investigator of the observing time proposals was Dr. E. C. Ford (U. of Amsterdam). The grant was funded for one year beginning 3/15/2000. The original ADP proposal was submitted by Prof. Jan van Paradijs, who passed away in 1999 before the funds were distributed. Prof. Wilham S. Padesas administered the grant during the period of performance. In spite of a wealth of observational data on the kHz QPO in low-mass X-ray binaries (LMXBs), the interpretation of this phenomenon is currently uncertain because the pairs of kHz QPO peaks and the oscillations seen in some Type I X-ray bursts are almost, but not quite, connected by a simple beat frequency relation. Further systematic studies of systems with known QPOs are required in order to better understand the phenomenon. The proposals were intended to contribute to a solution to this confusion by observing the sources as they vary over a wide range of X-ray flux. RXTE target-of-opportunity observations of six transient atoll sources, 4U 0614+09, KS 1732-260, Ser X-1, 4U 1702-42, 4U 1820-30 and 4U 1705-44 were to be performed at various flux levels based on ASM measurements.

  7. Electronic Structure and Energy Transfer in Europium(III)-Ciprofloxacin Complexes: A Theoretical Study.

    PubMed

    Emelina, Tatiana B; Freidzon, Alexandra Ya; Bagaturyants, Alexander A; Karasev, Vladimir E

    2016-09-29

    The structure and ligand-localized excited states of [Eu(cfqH) (cfq)(H2O)4]Cl2 (cfqH is ciprofloxacin) are studied by XMCQDPT2/CASSCF with full geometry optimization. The complex includes one anionic and one zwitterionic ligand. Two low-lying triplet states, both localized on the anionic ligand, are found. One of them has sufficient energy to transfer to the (5)D1 sublevel of Eu(3+), because its T-S0 vertical transition energy is equal (or very close) to the (7)F0-(5)D1 Eu(3+) excitation energy. The other triplet state has a very small S0-T1 gap, which favors fast nonradiative relaxation. Two other triplet states are localized on the zwitterionic ligand. One low-lying excited singlet state (S1) is localized on the anionic ligand; the other excited singlet is localized on the zwitterionic one. Spin-orbit coupling constants were calculated for the relaxed geometry of each state (ground state, two low-lying triplets, and one low-lying excited singlet) by spin-orbit configuration interaction (CI) with Pauli-Breit Hamiltonian. Large spin-orbit coupling constants between S1 and both triplets together with small energy gaps are indicative of fast intersystem crossing (ISC) from the excited singlet state to the triplet manifold. This ISC process is followed by energy transfer from the ligand-localized triplet states to the (5)D1 sublevel of Eu(3+). However, relatively large spin-orbit coupling constants between S0 and one of the triplet states together with the small T-S0 energy gap shows that this state can decay without transferring its energy to Eu(3+). This mechanism is expected to be common for other Ln(3+)-fluoroquinolone complexes.

  8. Idaho Water Rental Pilot Project Probability/Coordination Study Resident Fish and Wildlife Impacts Phase III, 1997 Annual Report.

    SciTech Connect

    Leitzinger, Eric J.

    1998-10-01

    Phase III began in 1995 with the overall goal of quantifying changes in resident fish habitat in the Snake River Basin upstream of Brownlee Reservoir resulting from the release of salmon flow augmentation water.

  9. III-V compound semiconductors for mass-produced nano-electronics: theoretical studies on mobility degradation by dislocation

    NASA Astrophysics Data System (ADS)

    Hur, Ji-Hyun; Jeon, Sanghun

    2016-02-01

    As silicon-based electronics approach the limit of scaling for increasing the performance and chip density, III-V compound semiconductors have started to attract significant attention owing to their high carrier mobility. However, the mobility benefits of III-V compounds are too easily accepted, ignoring a harmful effect of unavoidable threading dislocations that could fundamentally limit the applicability of these materials in nanometer-scale electronics. In this paper, we present a theoretical model that describes the degradation of carrier mobility by charged dislocations in quantum-confined III-V semiconductor metal oxide field effect transistors (MOSFETs). Based on the results, we conclude that in order for III-V compound MOSFETs to outperform silicon MOSFETs, Fermi level pinning in the channel should be eliminated for yielding carriers with high injection velocity.

  10. Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study

    PubMed Central

    Lauria, Giuseppe; Dalla Bella, Eleonora; Antonini, Giovanni; Borghero, Giuseppe; Capasso, Margherita; Caponnetto, Claudia; Chiò, Adriano; Corbo, Massimo; Eleopra, Roberto; Fazio, Raffaella; Filosto, Massimiliano; Giannini, Fabio; Granieri, Enrico; La Bella, Vincenzo; Logroscino, Giancarlo; Mandrioli, Jessica; Mazzini, Letizia; Monsurrò, Maria Rosaria; Mora, Gabriele; Pietrini, Vladimiro; Quatrale, Rocco; Rizzi, Romana; Salvi, Fabrizio; Siciliano, Gabriele; Sorarù, Gianni; Volanti, Paolo; Tramacere, Irene; Filippini, Graziella

    2015-01-01

    Objective To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS). Methods Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40 000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV). Secondary outcomes were ALSFRS-R, slow vital capacity (sVC) and quality of life (ALSAQ-40) decline. Tolerability was evaluated analysing adverse events (AEs) causing withdrawal. The randomisation sequence was computer-generated by blocks, stratified by centre, disease severity (ALSFRS-R cut-off score of 33) and onset (spinal or bulbar). The main outcome analysis was performed in all randomised patients and by intention-to-treat for the entire population and patients stratified by severity and onset. The study is registered, EudraCT 2009-016066-91. Results We randomly assigned 208 patients, of whom 5 (1 rhEPO and 4 placebo) withdrew consent and 3 (placebo) became ineligible (retinal thrombosis, respiratory insufficiency, SOD1 mutation) before receiving treatment; 103 receiving rhEPO and 97 placebo were eligible for analysis. At 12 months, the annualised rate of death (rhEPO 0.11, 95% CI 0.06 to 0.20; placebo: 0.08, CI 0.04 to 0.17), tracheotomy or >23 h NIV (rhEPO 0.16, CI 0.10 to 0.27; placebo 0.18, CI 0.11 to 0.30) did not differ between groups, also after stratification by onset and ALSFRS-R at baseline. Withdrawal due to AE was 16.5% in rhEPO and 8.3% in placebo. No differences were found for secondary outcomes. Conclusions RhEPO 40 000 IU fortnightly did not change the course of ALS. PMID:25595151

  11. Direct Grout Stabilization of High Cesium Salt Waste: Salt Alternative Phase III Feasibility Study

    SciTech Connect

    Langton, C.A.

    1998-12-07

    The direct grout alternative is a viable option for treatment/stabilization and disposal of salt waste containing Cs-137 concentrations of 1-3 Ci/gal. The composition of the direct grout salt solution is higher in sodium salts and contains up to a few hundred ppm Cs-137 more than the current reference salt solution. However it is still similar to the composition of the current reference salt solution. Consequently, the processing, setting, and leaching properties (including TCLP for Cr and Hg) of the direct grout and current saltstone waste forms are very similar. The significant difference between these waste solutions is that the high cesium salt solution will contain between 1 and 3 Curies of Cs-137 per gallon compared to a negligible amount in the current salt solution. This difference will require special engineering and shielding for a direct grout processing facility and disposal units to achieve acceptable radiation exposure conditions. The Cs-137 concentration in the direct grout salt solution will also affect the long-term curing temperature of the waste form since 4.84 Watts of energy are generated per 1000 Ci of Cs-137. The temperature rise of the direct grout during long-term curing has been calculated by A. Shaddy, SRTC.1 The effect of curing temperature on the strength, leaching and physical durability of the direct grout saltstone is described in this report. At the present time, long term curing at 90 degrees C appears to be unacceptable because of cracking which will affect the structural integrity as evaluated in the immersion test. (The experiments conducted in this feasibility study do not address the effect of cracking on leaching of contaminants other than Cr, Hg, and Cs.) No cracking of the direct grout or reference saltstone waste forms was observed for samples cured at 70 degrees C. At the present time the implications of waste form cracking at elevated curing temperatures has not been fully addressed. The direct grout falls within the

  12. Phase I/II study of 131I-MIBG with vincristine and 5 days of irinotecan for advanced neuroblastoma

    PubMed Central

    DuBois, S G; Allen, S; Bent, M; Hilton, J F; Hollinger, F; Hawkins, R; Courtier, J; Mosse, Y P; Matthay, K K

    2015-01-01

    Background: 131I-metaiodobenzylguanidine (MIBG) is an active radiopharmaceutical in neuroblastoma. A previous study demonstrated that MIBG could be combined with vincristine and prolonged irinotecan, although 25% of first courses had grade 3 diarrhoea. The current phase I/II study evaluated MIBG with vincristine and 5 days of higher-dose irinotecan. Methods: Patients 1–30 years old with advanced neuroblastoma were eligible. Patients received cefixime on days −1 to +6, irinotecan (50 mg m−2 per dose IV) on days 0–4, vincristine (2 mg m−2) on day 0, MIBG (555 or 666 MBq kg−1) on day 1, and peripheral blood stem cells on day 13. UGT1A1 genotyping was performed in consenting patients. Results: Thirty-two patients (12 phase I ; 20 phase II) received 42 courses. No dose-limiting toxicities were seen during dose escalation and the recommended administered activity was 666 MBq kg−1. Myelosuppression and diarrhoea were the most common toxicities, with grade 3 diarrhoea in 6% of first courses. Patients homozygous for UGT1A1*28 had more grade 4 thrombocytopenia (80% vs 37% P=0.14). Responses (five complete and four partial) occurred in 9 out of 32 (28%) patients. Conclusions: MIBG (666 MBq kg−1) with vincristine and this irinotecan schedule is tolerable and active, with less severe diarrhoea compared with a regimen using more protracted irinotecan. PMID:25602966

  13. RF thermal and new cold part design studies on TTF-III input coupler for Project-X

    SciTech Connect

    Pei, Shilun; Adolphsen, Chris E.; Li, Zenghai; Solyak, Nikolay A.; Gonin, Ivan V.

    2015-05-15

    An RF power coupler is one of the key components in a superconducting (SC) linac. It provides RF power to the SC cavity and interconnects different temperature layers (1.8 K, 4.2 K, 70 K and 300 K). The TTF-III coupler is one of the most promising candidates for the High Energy (HE) linac of Project X, but it cannot meet the average power requirements because of the relatively high temperature rise on the warm inner conductor, so some design modifications will be required. In this paper, we describe our simulation studies on the copper coating thickness on the warm inner conductor with RRR values of 10 and 100. Our purpose is to rebalance the dynamic and static loads, and finally lower the temperature rise along the warm inner conductor. Additionally, to get stronger coupling, better power handling and less multipacting probability, one new cold part design was proposed using a 60 mm coaxial line; the corresponding multipacting simulation studies have also been investigated.

  14. High level of depressive symptoms as a barrier to reach an ideal cardiovascular health. The Paris Prospective Study III

    PubMed Central

    Gaye, B.; Prugger, C.; Perier, M. C.; Thomas, F.; Plichart, M.; Guibout, C.; Lemogne, C.; Pannier, B.; Boutouyrie, P.; Jouven, X.; Empana, J. P.

    2016-01-01

    We hypothesized that depression might represent a barrier to reach an ideal cardiovascular health (CVH) as estimated by the 7-item tool proposed by the American Heart Association. Between 2008 and 2012, 9,417 subjects 50–75 years of age were examined in a large health center and enrolled in the Paris Prospective Study III (PPS3). Participants with 0–2, 3–4 and 5–7 health metrics at the ideal level were categorized as having poor, intermediate and ideal CVH, respectively. Participants with a score ≥7 on the 13-item Questionnaire of Depression 2nd version, Abridged or who were on antidepressants were referred as having high level of depressive symptoms (HLDS). The mean age of the 9417 study participants was 59.57 (SD 6.28) years and 61.16% were males. A total of 9.55% had HLDS. Poor, intermediate and ideal CVH was present in 40.38%, 49.52% and 10.10% of the participants. In multivariate polytomous logistic regression analysis, HLDS was inversely associated with ideal CVH (odds ratio = 0.70; 95% CI: 0.55;0.90). This was driven by an association with the behavioural component of the CVH. Participants with HLDS had a substantial reduced chance of reaching an ideal CVH. PMID:26743318

  15. LEAD STUDIES : III. THE EFFECTS OF LEAD ON RED BLOOD CELLS. PART 1. CHANGES IN HEMOLYSIS.

    PubMed

    Aub, J C; Reznikoff, P; Smith, D E

    1924-07-31

    It appears, from the investigations in other laboratories, that the anemia observed in cases of lead poisoning is due to destruction of blood rather than to diminished production of blood. The method of poisoning cells in vitro with lead was adopted in order to study this phenomenon, and distinct effects were thereby obtained, even when only 0.001 mg. of lead is added to approximately 5 billion washed red corpuscles. In order to obtain optimum results the usual dosage employed was ten times this or 0.01 mg. per 5 billion cells. The following changes were observed in cells so treated. 1. Such a marked increase in the resistance to hypotonic salt solution develops that complete hemolysis does not occur until the cells are exposed to a saline solution of 0.05 per cent. Untreated cells are completely hemolyzed in 0.25 or 0.225 per cent saline. 2. This reaction is quantitative and varies with the concentration of lead used. Under the conditions of our experiments this phenomenon seems to be unique. The effects of arsenic are very slight in comparison. 3. While from this reaction it may be concluded that lead increases cellular resistance, it also appears that it shortens the life of blood cells. This may be demonstrated by the much more rapid appearance of hemolysis than normal when the cells are merely allowed to stand in Ringer solution of any dilution. 4. In rabbits with acute lead poisoning these same phenomena may be noted in vivo. 5. Both phenomena may be changed in vitro by varying the time and temperature of the reaction and the concentration of lead, as Fici has already pointed out. 6. If normal cells stand in Ringer solution for 6 hours something diffuses into the solution which largely reduces the action of lead. After repeated washing these cells react with lead in the usual manner. 7. Small amounts of serum react with lead and eliminate its effects. Red blood cells, treated with a mixture of lead and blood serum, show normal hemolysis in hypotonic salt

  16. Analytical Study for Stress Wave Interaction with Rock Joints Having Unequally Close-Open Behavior

    NASA Astrophysics Data System (ADS)

    Li, J. C.; Zhao, X. B.; Li, H. B.; Chai, S. B.; Zhao, Q. H.

    2016-08-01

    Stress wave interaction with rock joints during wave propagation is usually dependent on the dynamic response of the joints. During wave propagation, joints may be closed and open under the effects of the stress wave and the in situ stress. A joint in nature can only resist load during close process. In this paper, the close and open behaviors of rock joints are considered to be different. The joints are assumed to be linearly elastic in close status but turn into free surfaces in open status. Wave propagation equation across joints with unequally close-open behavior is first derived and expressed as a time-differential form based on the displacement discontinuity method. SHPB test recording is then adopted to verify the present approach, which is also compared with the results from existing methods for joints with equally close-open behavior. Next, analysis is conduced for wave propagation across a single joint and a set of parallel joints with unequally close-open behavior, respectively. From the analysis, effects of unequally close-open behavior of a joint on wave propagation and the dynamic response of the joint are studied finally.

  17. A Phase I/II Radiation Dose Escalation Study With Concurrent Chemotherapy for Patients With Inoperable Stages I to III Non-Small-Cell Lung Cancer: Phase I Results of RTOG 0117

    SciTech Connect

    Bradley, Jeffrey D.; Moughan, Jennifer; Graham, Mary V.; Byhardt, Roger; Govindan, Ramaswamy; Fowler, Jack; Purdy, James A.; Michalski, Jeff M.; Gore, Elizabeth; Choy, Hak

    2010-06-01

    Purpose: In preparation for a Phase III comparison of high-dose versus standard-dose radiation therapy, this Phase I/II study was initiated to establish the maximum tolerated dose of radiation therapy in the setting of concurrent chemotherapy, using three-dimensional conformal radiation therapy for non-small-cell lung cancer. Methods and Materials: Eligibility included patients with histologically proven, unresectable Stages I to III non-small-cell lung cancer. Concurrent chemotherapy consisted of paclitaxel, 50 mg/m{sup 2}, and carboplatin, AUC of 2, given weekly. The radiation dose was to be sequentially intensified by increasing the daily fraction size, starting from 75.25 Gy/35 fractions. Results: The Phase I portion of this study accrued 17 patients from 10 institutions and was closed in January 2004. After the initial 8 patients were accrued to cohort 1, the trial closed temporarily on September 26, 2002, due to reported toxicity. Two acute treatment-related dose-limiting toxicities (DLTs) were reported at the time: a case of grade 5 and grade 3 radiation pneumonitis. The protocol, therefore, was revised to de-escalate the radiation therapy dose (74 Gy/37 fractions). Patients in cohort 1 continued to develop toxicity, with 6/8 (75%) patients eventually developing grade >=3 events. Cohort 2 accrued 9 patients. There was one DLT, a grade 3 esophagitis, in cohort 2 in the first 5 patients (1/5 patients) and no DLTs for the next 2 patients (0/2 patients). Conclusions: The maximum tolerated dose was determined to be 74 Gy/37 fractions (2.0 Gy per fraction) using three-dimensional conformal radiation therapy with concurrent paclitaxel and carboplatin therapy. This dose level in the Phase II portion has been well tolerated, with low rates of acute and late lung toxicities.

  18. A feasibility study on porting the community land model onto accelerators using OpenACC

    DOE PAGES

    Wang, Dali; Wu, Wei; Winkler, Frank; Ding, Wei; Hernandez, Oscar R.

    2014-01-01

    As environmental models (such as Accelerated Climate Model for Energy (ACME), Parallel Reactive Flow and Transport Model (PFLOTRAN), Arctic Terrestrial Simulator (ATS), etc.) became more and more complicated, we are facing enormous challenges regarding to porting those applications onto hybrid computing architecture. OpenACC appears as a very promising technology, therefore, we have conducted a feasibility analysis on porting the Community Land Model (CLM), a terrestrial ecosystem model within the Community Earth System Models (CESM)). Specifically, we used automatic function testing platform to extract a small computing kernel out of CLM, then we apply this kernel into the actually CLM dataflowmore » procedure, and investigate the strategy of data parallelization and the benefit of data movement provided by current implementation of OpenACC. Even it is a non-intensive kernel, on a single 16-core computing node, the performance (based on the actual computation time using one GPU) of OpenACC implementation is 2.3 time faster than that of OpenMP implementation using single OpenMP thread, but it is 2.8 times slower than the performance of OpenMP implementation using 16 threads. On multiple nodes, MPI_OpenACC implementation demonstrated very good scalability on up to 128 GPUs on 128 computing nodes. This study also provides useful information for us to look into the potential benefits of “deep copy” capability and “routine” feature of OpenACC standards. In conclusion, we believe that our experience on the environmental model, CLM, can be beneficial to many other scientific research programs who are interested to porting their large scale scientific code using OpenACC onto high-end computers, empowered by hybrid computing architecture.« less

  19. A feasibility study on porting the community land model onto accelerators using OpenACC

    SciTech Connect

    Wang, Dali; Wu, Wei; Winkler, Frank; Ding, Wei; Hernandez, Oscar R.

    2014-01-01

    As environmental models (such as Accelerated Climate Model for Energy (ACME), Parallel Reactive Flow and Transport Model (PFLOTRAN), Arctic Terrestrial Simulator (ATS), etc.) became more and more complicated, we are facing enormous challenges regarding to porting those applications onto hybrid computing architecture. OpenACC appears as a very promising technology, therefore, we have conducted a feasibility analysis on porting the Community Land Model (CLM), a terrestrial ecosystem model within the Community Earth System Models (CESM)). Specifically, we used automatic function testing platform to extract a small computing kernel out of CLM, then we apply this kernel into the actually CLM dataflow procedure, and investigate the strategy of data parallelization and the benefit of data movement provided by current implementation of OpenACC. Even it is a non-intensive kernel, on a single 16-core computing node, the performance (based on the actual computation time using one GPU) of OpenACC implementation is 2.3 time faster than that of OpenMP implementation using single OpenMP thread, but it is 2.8 times slower than the performance of OpenMP implementation using 16 threads. On multiple nodes, MPI_OpenACC implementation demonstrated very good scalability on up to 128 GPUs on 128 computing nodes. This study also provides useful information for us to look into the potential benefits of “deep copy” capability and “routine” feature of OpenACC standards. In conclusion, we believe that our experience on the environmental model, CLM, can be beneficial to many other scientific research programs who are interested to porting their large scale scientific code using OpenACC onto high-end computers, empowered by hybrid computing architecture.

  20. Column study on the adsorption of Cr(III) and Cr(VI) using Pumice, Yarikkaya brown coal, Chelex-100 and Lewatit MP 62.

    PubMed

    Gode, Fethiye; Moral, Emel

    2008-04-01

    In the present study, adsorption of Cr(III) and Cr(VI) on Pumice (Pmc), Yarikkaya (YK) brown coal, Chelex-100, and Lewatit MP 62 is examined at room temperature and at initial chromium concentration of 1.0 x 10(-3) mol/L. Column method was carried out as a function of pH, concentration of Cr(III) and Cr(VI) ions, volume of samples and flow rate. The experimental data were evaluated by Freundlich and Langmuir isotherm models. The dynamic breakthrough capacities of the adsorbents for Cr(III) and Cr(VI) were calculated. The maximum chromium sorption occurred at 5 mL/min flow rate and 25 mL volume for all adsorbents. The results showed that the two readily available adsorbents namely Pmc and YK, were suitable for removing chromium from aqueous solution.