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  1. Laparoscopic versus open colectomy for TNM stage III colon cancer: results of a prospective multicenter study in Italy.

    PubMed

    Guerrieri, Mario; Campagnacci, Roberto; De Sanctis, Angelo; Lezoche, Giovanni; Massucco, Paolo; Summa, Massimo; Gesuita, Rosaria; Capussotti, Lorenzo; Spinoglio, Giuseppe; Lezoche, Emanuele

    2012-11-01

    There is still debate about the practicality of performing laparoscopic colectomy instead of open colectomy for patients with curable cancer, although laparoscopic surgery is now being performed even for patients with advanced colon cancer. We compared the long-term results of laparoscopic versus open colectomy for TNM stage III carcinoma of the colon in a large series of patients followed up for at least 3 years. The subjects of this prospective non-randomized multicentric study were 290 consecutive patients, who underwent open surgery (OS group; n = 164) or laparoscopic surgery (LS group; n = 126) between 1994 and 2005, at one of the four surgical centers. The same surgical techniques were used for the laparoscopic and open approaches to right and left colectomy. The distribution of TNM substages (III A, III B, IIIC) as well as the grading of carcinomas (G1, G2, G3) were similar in each arm of the study. The median follow-up periods were 76.9 and 58.0 months after OS and LS, respectively. There were 10 (6.1 %) versus 9 (7.1 %) deaths unrelated to cancer, 15 (9.1 %) versus 5 (4 %) cases of local recurrence, 7 (4.2 %) versus 5 (4 %) cases of peritoneal carcinosis, and 37 (22.5 %) versus 14 (11.1 %) cases of metastases in the OS and LS groups, respectively. There was also one case of port-site recurrence after LS (0.8 %). The OS group had a significantly higher probability of local recurrence and metastases (p < 0.001) with a significant higher probability of cancer-related death (p = 0.001) than the LS group. These findings support that LS is safe and effective for advanced carcinoma of the colon. Although the LS group in this study had a significantly better long-term outcome than the OS group, further investigations are needed to draw a definitive conclusion.

  2. Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study

    PubMed Central

    Xu, Yichen; Chen, Yanzhi

    2015-01-01

    Abstract Objectives: This open-label, prospective, phase I/II trial was performed to establish the safety and efficacy of Traditional Chinese Medicine (TCM) herbal products for treating non–anemia-related fatigue in patients with cancer. Although this practice is widespread in China, it has not been confirmed in a prospective clinical study. Design: Thirty-three patients who had completed cancer treatment, had stable disease and no anemia, and reported moderate to severe fatigue (rated ≥4 on a 0–10 scale) were enrolled in a TCM outpatient clinic. Patients took Ren Shen Yangrong Tang (RSYRT) decoction, a soup containing 12 TCM herbs, twice a day for 6 weeks. RSYRT aims to correct qi deficiency. Fatigue was assessed before and after RSYRT therapy, which all patients completed. Results: No discomfort or toxicity was observed. Before the study, all patients had had fatigue for at least 4 months. Fatigue severity decreased significantly from before therapy to 6 weeks after therapy: from 7.06 to 3.30 on a 0–10 scale (p<0.001). Fatigue category (mild, moderate, severe) shifted significantly (p=0.024): Of 22 patients with severe fatigue (rated ≥7) before therapy, 11 had mild fatigue and 11 had moderate fatigue after TCM treatment. The time-to-fatigue-alleviation was 2–3 weeks. Conclusion: RSYRT therapy was safe and was associated with fatigue improvement in nonanemic cancer survivors, consistent with historical TCM clinical practice experience. Because of a possible placebo effect in this open-label study, decoction RSYRT warrants further study in randomized clinical trials to confirm its effectiveness for managing moderate to severe fatigue. PMID:25918996

  3. A New Viscous Cysteamine Eye Drops Treatment for Ophthalmic Cystinosis: An Open-Label Randomized Comparative Phase III Pivotal Study.

    PubMed

    Liang, Hong; Labbé, Antoine; Le Mouhaër, Jeannie; Plisson, Céline; Baudouin, Christophe

    2017-04-01

    The purpose of this study was to evaluate the efficacy of new viscous cysteamine hydrochloride (CH) eye drops (vCH 0.55%) compared with standard CH 0.10% drops treatment. This was an open-label, phase III, randomized, two-arm multicenter trial conducted at two centers in France. Cystinosis patients ≥2 years old were randomized 1:1 to receive eye drops, four times per day for 90 days in both eyes. We compared the superiority in reducing corneal cystine crystal density as assessed by in vivo confocal microscopy (IVCM). We also evaluated photophobia, corneal cystine crystal scores (CCCSs), and cystine crystal depth measured by optical coherence tomography. Safety objectives were to assess adverse events (AEs), local adverse drug reactions, and ocular safety parameters. We included 15 patients with vCH 0.55% and 16 patients with CH 0.10% drops for 90 days. The mean absolute change in IVCM total score at day 90 in the vCH 0.55% drops group (-4.6 ± 3.1) was significantly greater than and superior to the mean absolute change in the CH 0.10% drops group (-0.46 ± 3.38; P < 0.0001). Photophobia, CCCS, and corneal cystine crystal depth were significantly more improved in the vCH 0.55% drops group than in the CH 0.10% group. The most frequent local adverse drug reactions in both groups were stinging, burning, redness, and blurred vision. vCH 0.55% was effective in reducing corneal cystine crystal density and superior to treatment with CH 0.10% drops, which offer advantages over hospital pharmacy formulations and is a more preferable and convenient treatment option.

  4. Open-label, randomized, comparative, phase III study on effects of reducing steroid use in combination with Palonosetron

    PubMed Central

    Komatsu, Yoshito; Okita, Kenji; Yuki, Satoshi; Furuhata, Tomohisa; Fukushima, Hiraku; Masuko, Hiroyuki; Kawamoto, Yasuyuki; Isobe, Hiroshi; Miyagishima, Takuto; Sasaki, Kazuaki; Nakamura, Michio; Ohsaki, Yoshinobu; Nakajima, Junta; Tateyama, Miki; Eto, Kazunori; Minami, Shinya; Yokoyama, Ryoji; Iwanaga, Ichiro; Shibuya, Hitoshi; Kudo, Mineo; Oba, Koji; Takahashi, Yasuo

    2015-01-01

    The purpose of this study is to compare the efficacy of a single administration of dexamethasone (DEX) on day 1 against DEX administration on days 1–3 in combination with palonosetron (PALO), a second-generation 5-HT3 receptor antagonist, for chemotherapy-induced nausea and vomiting (CINV) in non-anthracycline and cyclophosphamide (AC) moderately-emetogenic chemotherapy (MEC). This phase III trial was conducted with a multi-center, randomized, open-label, non-inferiority design. Patients who received non-AC MEC as an initial chemotherapy were randomly assigned to either a group administered PALO (0.75 mg, i.v.) and DEX (9.9 mg, i.v.) prior to chemotherapy (study treatment group), or a group administered additional DEX (8 mg, i.v. or p.o.) on days 2–3 (control group). The primary endpoint was complete response (CR) rate. The CR rate difference was estimated by logistic regression with allocation factors as covariates. The non-inferiority margin was set at −15% (study treatment group − control group). From April 2011 to March 2013, 305 patients who received non-AC MEC were randomly allocated to one of two study groups. Overall, the CR rate was 66.2% in the study treatment group (N = 151) and 63.6% in the control group (N = 154). PALO plus DEX day 1 was non-inferior to PALO plus DEX days 1–3 (difference, 2.5%; 95% confidence interval [CI]: −7.8%–12.8%; P-value for non-inferiority test = 0.0004). There were no differences between the two groups in terms of complete control rate (64.9 vs 61.7%) and total control rate (49.7% vs 47.4%). Anti-emetic DEX administration on days 2–3 may be eliminated when used in combination with PALO in patients receiving non-AC MEC. PMID:25872578

  5. A randomized Phase III trial of thoracoscopic versus open esophagectomy for thoracic esophageal cancer: Japan Clinical Oncology Group Study JCOG1409.

    PubMed

    Kataoka, Kozo; Takeuchi, Hiroya; Mizusawa, Junki; Ando, Masahiko; Tsubosa, Yasuhiro; Koyanagi, Kazuo; Daiko, Hiroyuki; Matsuda, Satoru; Nakamura, Kenichi; Kato, Ken; Kitagawa, Yuko

    2016-02-01

    A randomized Phase III study was commenced in May 2015 to confirm the non-inferiority of thoracoscopic esophagectomy to open esophagectomy in terms of overall survival for clinical Stage I-III esophageal cancer. A total of 300 patients will be accrued from Japanese institutions over 6 years. The primary endpoint is overall survival. The secondary endpoints are relapse-free survival, proportion of patients with R0 resection, proportion of patients who underwent re-operation, adverse events, postoperative respiratory function change, postoperative quality-of-life score (EORTC QLQ-C30), and proportion of patients who need conversion from thoracoscopic surgery to open surgery. This trial has been registered in the UMIN Clinical Trials Registry as UMIN000017628.

  6. Long-term oncologic outcomes of laparoscopic vs open surgery for stages II and III rectal cancer: A retrospective cohort study

    PubMed Central

    Zhou, Zhen-Xu; Zhao, Li-Ying; Lin, Tian; Liu, Hao; Deng, Hai-Jun; Zhu, Heng-Liang; Yan, Jun; Li, Guo-Xin

    2015-01-01

    AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages II and III rectal cancer. METHODS: This study enrolled 406 consecutive patients who underwent curative resection for stages II and III rectal cancer between January 2000 and December 2009 [laparoscopic rectal resection (LRR), n = 152; open rectal resection (ORR), n = 254]. Clinical characteristics, operative outcomes, pathological outcomes, postoperative recovery, and 5-year survival outcomes were compared between the two groups. RESULTS: Most of the clinical characteristics were similar except age (59 years vs 55 years, P = 0.033) between the LRR group and ORR group. The proportion of anterior resection was higher in the LRR group than that in the ORR group (81.6% vs 66.1%, P = 0.001). The LRR group had less estimated blood loss (50 mL vs 200 mL, P < 0.001) and a lower rate of blood transfusion (4.6% vs 11.8%, P = 0.019) compared to the ORR group. The pathological outcomes of the two groups were comparable. The LRR group was associated with faster recovery of bowel function (2.8 d vs 3.7 d, P < 0.001) and shorter postoperative hospital stay (11.7 d vs 13.7 d, P < 0.001). The median follow-up time was 63 mo in the LRR group and 65 mo in the ORR group. As for the survival outcomes, the 5-year local recurrence rate (16.0% vs 16.4%, P = 0.753), 5-year disease-free survival (DFS) rate (63.0% vs 63.1%, P = 0.589), and 5-year overall survival (OS) rate (68.1% vs 63.5%, P = 0.682) were comparable between the LRR group and the ORR group. Stage by stage, there were also no statistical differences between the LRR group and the ORR group in terms of the 5-year local recurrence rate (stage II: 6.3% vs 8.7%, P = 0.623; stage III: 26.4% vs 23.2%, P = 0.747), 5-year DFS rate (stage II: 77.5% vs 77.6%, P = 0.462; stage III: 46.5% vs 50.9%, P = 0.738), and 5-year OS rate (stage II: 81.4% vs 74.3%, P = 0.242; stage III: 53.9% vs 54.1%, P = 0.459). CONCLUSION: LRR for stages II and III rectal

  7. Funduscopic versus HRT III Confocal Scanner Vertical Cup-Disc Ratio Assessment in Normal Tension and Primary Open Angle Glaucoma (The Leuven Eye Study).

    PubMed

    Willekens, Koen; Bataillie, Sophie; Sarens, Inge; Odent, Sofie; Abegão Pinto, Luìs; Vandewalle, Evelien; Van Keer, Karel; Stalmans, Ingeborg

    2017-01-01

    To compare funduscopic and confocal scanning vertical cup-disc ratio (VCDR) assessments and their respective predictive value for estimating functional glaucomatous damage. Data from a single eye of open angle glaucoma patients from the Leuven Eye Study were included: age, gender, intra-ocular pressure, visual acuity, refractive error, visual field mean deviation and pattern standard deviation, funduscopic and HRT III VCDRs as well as mean retinal nerve fibre layer thickness. Non-parametric tests to compare differences within and between diagnostic groups were used, and receiver-operating characteristic curves as well as Bland-Altman plots constructed. Three hundred and one eyes of 301 subjects with primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) were included. The average VCDR assessed with HRT III was significantly smaller than the funduscopic measurement (0.69 ± 0.16 vs. 0.81 ± 0.14, respectively; p < 0.001). The predictive value of both measurement techniques did not differ in NTG patients, but the funduscopic estimate yielded a significantly larger predictive power in patients with severe POAG. Funduscopic and confocal scanner estimates of VCDR differ significantly and should not be used interchangeably. In POAG patients with severe glaucoma, a subjective VCDR predicts functional glaucomatous damage significantly better. © 2016 S. Karger AG, Basel.

  8. Low-dose SoluMatrix diclofenac in the treatment of osteoarthritis: A 1-year, open-label, Phase III safety study.

    PubMed

    Altman, Roy D; Strand, Vibeke; Hochberg, Marc C; Gibofsky, Allan; Markenson, Joseph A; Hopkins, William E; Cryer, Byron; Kivitz, Alan; Nezzer, Jennifer; Imasogie, Olaolu; Young, Clarence L

    2015-06-01

    Diclofenac is used for the treatment of osteoarthritis (OA); however, like other nonsteroidal anti-inflammatory drugs (NSAIDs) it can be associated with serious dose-related adverse events (AEs). Low-dose SoluMatrix® diclofenac has been developed to provide efficacy at lower diclofenac doses. A recently published Phase III study evaluated the efficacy and safety of SoluMatrix diclofenac 35 mg twice daily (b.i.d.) and thrice daily (t.i.d.) in patients with OA pain treated for 12 weeks. This Phase III multicenter, open-label study assessed the safety of SoluMatrix diclofenac in patients with OA dosed up to 52 weeks (ClinicalTrials.gov: NCT01510912). The study enrolled 602 chronic NSAID/acetaminophen users, aged ≥40 years with OA of the knee or hip. Patients received SoluMatrix diclofenac 35 mg b.i.d., which could be increased to t.i.d. and subsequently reduced to b.i.d. as needed. Safety assessments included AEs, vital signs, physical examination findings, 12-lead electrocardiogram, and clinical laboratory test results. Patient-reported outcomes were evaluated by the Short Form-36 (SF-36). A total of 601 patients received SoluMatrix diclofenac; 373 of 601 patients (62.1%) received treatment for ≥11 months. The most frequent AEs included upper respiratory tract infection, headache, urinary tract infection, diarrhea, nasopharyngitis, and nausea. Serious gastrointestinal, cardiovascular, renal, and hepatic AEs were uncommon. A small proportion (99 patients, 16.5%) of patients discontinued participation in the study due to AEs. Clinically meaningful improvements from baseline in Physical Component Summary Scores of the SF-36 were noted at week 12 and were sustained through week 52. Improvements in six of the eight individual physical and mental SF-36 domains were also noted. SoluMatrix diclofenac treatment for up to 1 year was generally well tolerated in patients with OA pain and associated with improvement in quality of life measures. www

  9. Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open-label multicenter Japanese study.

    PubMed

    Imafuku, Shinichi; Honma, Masaru; Okubo, Yukari; Komine, Mayumi; Ohtsuki, Mamitaro; Morita, Akimichi; Seko, Noriko; Kawashima, Naoko; Ito, Saori; Shima, Tomohiro; Nakagawa, Hidemi

    2016-09-01

    Generalized pustular psoriasis (GPP) is a severe inflammatory skin disease characterized by the presence of sterile pustules covering almost the entire body and systemic symptoms such as fever. Secukinumab, a fully human-recombinant anti-interleukin-17A monoclonal antibody was indicated for psoriasis vulgaris and psoriatic arthritis in Japan but is not yet investigated for GPP. In this phase III, open-label multicenter single arm study, the efficacy and safety of secukinumab as monotherapy or with co-medication was evaluated in 12 Japanese patients with GPP. All the patients received secukinumab 150 mg s.c. at baseline, week 1, 2, 3 and 4, and then every 4 weeks. Two non-responders were up-titrated to 300 mg. Change in GPP severity from baseline was evaluated by clinical global impression (CGI) categorized as "worsened", "no change", "minimally improved", "much improved" or "very much improved". Treatment success was achieved by 83.3% (n = 10) of patients at week 16 (primary end-point) with CGI evaluated as "very much improved" (n = 9) and "much improved" (n = 1). Moreover, the area of erythema with pustules improved as early as week 1 and resolved by week 16 in most of the patients. The improvements were sustained throughout 52 weeks. Over the 52-week treatment period, secukinumab was well tolerated with no unexpected safety signals. Nasopharyngitis, urticaria, diabetes mellitus and arthralgia were the frequent adverse events reported. The data from this study shows that secukinumab can become one of the potent treatment options for GPP. © 2016 Japanese Dermatological Association.

  10. Efficacy and safety of leuprorelin acetate 6-month depot in prostate cancer patients: a Phase III, randomized, open-label, parallel-group, comparative study in Japan.

    PubMed

    Suzuki, Kazuhiro; Namiki, Mikio; Fujimoto, Tsukasa; Takabayashi, Nobuyoshi; Kudou, Kentarou; Akaza, Hideyuki

    2015-12-01

    Leuprorelin acetate (TAP-144-SR) is commonly used worldwide in prostate cancer patients. This study was conducted to assess the non-inferiority of a 6-month depot formulation of TAP-144-SR (TAP-144-SR [6M]) 22.5 mg to a 3-month depot formulation of TAP-144-SR (TAP-144-SR [3M]) 11.25 mg in prostate cancer patients in Japan. This was a 48-week Phase III, open-label, parallel-group comparative study. TAP-144-SR (6M) 22.5 mg (6M group) and TAP-144-SR (3M) 11.25 mg (3M group) were administered to 81 and 79 subjects, respectively. The primary endpoint was the rate of serum testosterone suppression to the castrate level (≤100 ng/dl). Serum testosterone of all subjects excluding one subject in the 3M group was suppressed to the castrate level throughout 48 weeks. The estimated between-group difference (6M group - 3M group) in suppression rate was 1.3% (95% confidence interval: -3.4, 6.8), and its lower confidence interval was more than -10% of the pre-determined allowable limit value to judge the non-inferiority. The prostate-specific antigen concentrations were stable throughout the study in both groups. Progressive disease in the best overall response based on the Response Evaluation Criteria In Solid Tumors was 0.0% for the 6M group and 2.6% for the 3M group. Adverse events occurred in 92.6% in the 6M group and 89.9% in the 3M group. Adverse events leading to discontinuation were reported in 2.5% in the 6M group and 3.8% in the 3M group. TAP-144-SR (6M) was not inferior to TAP-144-SR (3M) for the suppressive effect on serum testosterone level. TAP-144-SR (6M) was also as well tolerated as TAP-144-SR (3M). © The Author 2015. Published by Oxford University Press.

  11. Efficacy and safety of leuprorelin acetate 6-month depot in prostate cancer patients: a Phase III, randomized, open-label, parallel-group, comparative study in Japan

    PubMed Central

    Suzuki, Kazuhiro; Namiki, Mikio; Fujimoto, Tsukasa; Takabayashi, Nobuyoshi; Kudou, Kentarou; Akaza, Hideyuki

    2015-01-01

    Objective Leuprorelin acetate (TAP-144-SR) is commonly used worldwide in prostate cancer patients. This study was conducted to assess the non-inferiority of a 6-month depot formulation of TAP-144-SR (TAP-144-SR [6M]) 22.5 mg to a 3-month depot formulation of TAP-144-SR (TAP-144-SR [3M]) 11.25 mg in prostate cancer patients in Japan. Methods This was a 48-week Phase III, open-label, parallel-group comparative study. TAP-144-SR (6M) 22.5 mg (6M group) and TAP-144-SR (3M) 11.25 mg (3M group) were administered to 81 and 79 subjects, respectively. The primary endpoint was the rate of serum testosterone suppression to the castrate level (≤100 ng/dl). Results Serum testosterone of all subjects excluding one subject in the 3M group was suppressed to the castrate level throughout 48 weeks. The estimated between-group difference (6M group − 3M group) in suppression rate was 1.3% (95% confidence interval: −3.4, 6.8), and its lower confidence interval was more than −10% of the pre-determined allowable limit value to judge the non-inferiority. The prostate-specific antigen concentrations were stable throughout the study in both groups. Progressive disease in the best overall response based on the Response Evaluation Criteria In Solid Tumors was 0.0% for the 6M group and 2.6% for the 3M group. Adverse events occurred in 92.6% in the 6M group and 89.9% in the 3M group. Adverse events leading to discontinuation were reported in 2.5% in the 6M group and 3.8% in the 3M group. Conclusions TAP-144-SR (6M) was not inferior to TAP-144-SR (3M) for the suppressive effect on serum testosterone level. TAP-144-SR (6M) was also as well tolerated as TAP-144-SR (3M). PMID:26486824

  12. Triptorelin 6-month formulation in the management of patients with locally advanced and metastatic prostate cancer: an open-label, non-comparative, multicentre, phase III study.

    PubMed

    Lundström, Eija A; Rencken, Rupert K; van Wyk, Johann H; Coetzee, Lance J E; Bahlmann, Johann C M; Reif, Simon; Strasheim, Erdam A; Bigalke, Martin C; Pontin, Alan R; Goedhals, Louis; Steyn, Douw G; Heyns, Chris F; Aldera, Luigi A; Mackenzie, Thomas M; Purcea, Daniela; Grosgurin, Pierre Y; Porchet, Hervé C

    2009-01-01

    Triptorelin 6-month formulation was developed to offer greater convenience to both patients and physicians by reducing the injection frequency. The efficacy, pharmacokinetics and safety of a new 6-month formulation of triptorelin were investigated over 12 months (48 weeks). The primary objective was to evaluate the formulation in achieving castrate serum testosterone levels (< or = 1.735 nmol/L or < or = 50 ng/dL) on day 29 and in maintaining castration at months 2-12. Absence of luteinizing hormone (LH) stimulation and change in prostate-specific antigen (PSA) level were also assessed. An open-label, non-comparative, phase III study in 120 patients with advanced prostate cancer was conducted from July 2006 to August 2007 in private and public institutions in South Africa. Each patient received two consecutive intramuscular injections of triptorelin embonate (pamoate) 22.5 mg at an interval of 24 weeks. In all patients, testosterone (primary outcome measurement) was measured at baseline and then every 4 weeks; LH was measured before and 2 hours after the two injections. PSA was measured on day 1 and at weeks 12, 24, 36 and 48. Adverse events were recorded at each visit. In the intent-to-treat population, 97.5% (95% CI 92.9, 99.5) of patients achieved castrate serum testosterone levels by day 29, and 93.0% (95% CI 86.8, 97.0) maintained castration at months 2-12. After the second injection, 98.3% of patients showed absence of LH stimulation. The most frequent drug-related adverse events were hot flushes (71.7% of patients). No patient withdrew from the study as a result of an adverse event. The triptorelin 6-month formulation was well tolerated and was able to achieve and maintain castration for the treatment of locally advanced and metastatic prostate cancer. By reducing the frequency of required injections, this new formulation offers a more convenient treatment regimen. (Clinical Trial Registration,NCT00751790 at www.clinicaltrials.gov).

  13. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

    PubMed Central

    Fenaux, Pierre; Mufti, Ghulam J; Hellstrom-Lindberg, Eva; Santini, Valeria; Finelli, Carlo; Giagounidis, Aristoteles; Schoch, Robert; Gattermann, Norbert; Sanz, Guillermo; List, Alan; Gore, Steven D; Seymour, John F; Bennett, John M; Byrd, John; Backstrom, Jay; Zimmerman, Linda; McKenzie, David; Beach, C L; Silverman, Lewis R

    2014-01-01

    Summary Background Drug treatments for patients with high-risk myelodysplastic syndromes provide no survival advantage. In this trial, we aimed to assess the effect of azacitidine on overall survival compared with the three commonest conventional care regimens. Methods In a phase III, international, multicentre, controlled, parallel-group, open-label trial, patients with higher-risk myelodysplastic syndromes were randomly assigned one-to-one to receive azacitidine (75 mg/m² per day for 7 days every 28 days) or conventional care (best supportive care, low-dose cytarabine, or intensive chemotherapy as selected by investigators before randomisation). Patients were stratified by French–American–British and international prognostic scoring system classifications; randomisation was done with a block size of four. The primary endpoint was overall survival. Efficacy analyses were by intention to treat for all patients assigned to receive treatment. This study is registered with ClinicalTrials.gov, number NCT00071799. Findings Between Feb 13, 2004, and Aug 7, 2006, 358 patients were randomly assigned to receive azacitidine (n=179) or conventional care regimens (n=179). Four patients in the azacitidine and 14 in the conventional care groups received no study drugs but were included in the intention-to-treat efficacy analysis. After a median follow-up of 21·1 months (IQR 15·1–26·9), median overall survival was 24·5 months (9·9–not reached) for the azacitidine group versus 15·0 months (5·6–24·1) for the conventional care group (hazard ratio 0·58; 95% CI 0·43–0·77; stratified log-rank p=0·0001). At last follow-up, 82 patients in the azacitidine group had died compared with 113 in the conventional care group. At 2 years, on the basis of Kaplan-Meier estimates, 50·8% (95% CI 42·1–58·8) of patients in the azacitidine group were alive compared with 26·2% (18·7–34·3) in the conventional care group (p<0·0001). Peripheral cytopenias were the most

  14. Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren's syndrome: an open-label phase I/II study

    PubMed Central

    Steinfeld, Serge D; Tant, Laure; Burmester, Gerd R; Teoh, Nick KW; Wegener, William A; Goldenberg, David M; Pradier, Olivier

    2006-01-01

    This open-label, phase I/II study investigated the safety and efficacy of epratuzumab, a humanised anti-CD22 monoclonal antibody, in the treatment of patients with active primary Sjögren's syndrome (pSS). Sixteen Caucasian patients (14 females/2 males, 33–72 years) were to receive 4 infusions of 360 mg/m2 epratuzumab once every 2 weeks, with 6 months of follow-up. A composite endpoint involving the Schirmer-I test, unstimulated whole salivary flow, fatigue, erythrocyte sedimentation rate (ESR), and immunoglobulin G (IgG) was devised to provide a clinically meaningful assessment of response, defined as a ≥20% improvement in at least two of the aforementioned parameters, with ≥20% reduction in ESR and/or IgG considered as a single combined criterion. Fourteen patients received all infusions without significant reactions, 1 patient received 3, and another was discontinued due to a mild acute reaction after receiving a partial infusion. Three patients showed moderately elevated levels of Human anti-human (epratuzumab) antibody not associated with clinical manifestations. B-cell levels had mean reductions of 54% and 39% at 6 and 18 weeks, respectively, but T-cell levels, immunoglobulins, and routine safety laboratory tests did not change significantly. Fifty-three percent achieved a clinical response (at ≥20% improvement level) at 6 weeks, with 53%, 47%, and 67% responding at 10, 18, and 32 weeks, respectively. Approximately 40%–50% responded at the ≥30% level, while 10%–45% responded at the ≥50% level for 10–32 weeks. Additionally, statistically significant improvements were observed in fatigue, and patient and physician global assessments. Further, we determined that pSS patients have a CD22 over-expression in their peripheral B cells, which was downregulated by epratuzumab for at least 12 weeks after the therapy. Thus, epratuzumab appears to be a promising therapy in active pSS, suggesting that further studies be conducted. PMID:16859536

  15. Immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine: a Phase III, open-label study of adults in Brazil.

    PubMed

    Zerbini, Cristiano A F; Ribeiro Dos Santos, Rodrigo; Jose Nunes, Maria; Soni, Jyoti; Li, Ping; Jain, Varsha K; Ofori-Anyinam, Opokua

    The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines. In this Phase III, open-label study, we assessed the immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine (Fluarix™ Tetra) in Brazilian adults (NCT02369341). The primary objective was to assess hemagglutination-inhibition antibody responses against each vaccine strain 21 days after vaccination in adults (aged ≥18-60 years) and older adults (aged >60 years). Solicited adverse events for four days post-vaccination, and unsolicited adverse events and serious adverse events for 21 days post-vaccination were also assessed. A total of 63 adults and 57 older adults received one dose of inactivated quadrivalent influenza vaccine at the beginning of the 2015 Southern Hemisphere influenza season. After vaccination, in adults and older adults, the hemagglutination-inhibition titers fulfilled the European licensure criteria for immunogenicity. In adults, the seroprotection rates with HI titer ≥1:40 were 100% (A/H1N1), 98.4% (A/H3N2), 100% (B/Yamagata), and 100% (B/Victoria); in older adults were 94.7% (A/H1N1), 96.5% (A/H3N2), 100% (B/Yamagata), and 100% (B/Victoria). Pain was the most common solicited local adverse events in adults (27/62) and in older adults (13/57), and the most common solicited general adverse events in adults was myalgia (9/62), and in older adults were myalgia and arthralgia (both 2/57). Unsolicited adverse events were reported by 11/63 adults and 10/57 older adults

  16. STRATEGIC-1: A multiple-lines, randomized, open-label GERCOR phase III study in patients with unresectable wild-type RAS metastatic colorectal cancer.

    PubMed

    Chibaudel, Benoist; Bonnetain, Franck; Tournigand, Christophe; de Larauze, Marine Hug; de Gramont, Armand; Laurent-Puig, Pierre; Paget, Jérôme; Hadengue, Alexandra; Notelet, Dominique; Benetkiewicz, Magdalena; André, Thierry; de Gramont, Aimery

    2015-07-04

    The management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan), molecular-targeted agents such as anti-angiogenic agents (bevacizumab, aflibercept, regorafenib) and anti-epidermal growth factor receptor agents (cetuximab, panitumumab) have become available. Ultimately, given the increasing cost of new active compounds, new strategy trials are needed to define the optimal use and the best sequencing of these agents. Such new clinical trials require alternative endpoints that can capture the effect of several treatment lines and be measured earlier than overall survival to help shorten the duration and reduce the size and cost of trials. STRATEGIC-1 is an international, open-label, randomized, multicenter phase III trial designed to determine an optimally personalized treatment sequence of the available treatment modalities in patients with unresectable RAS wild-type mCRC. Two standard treatment strategies are compared: first-line FOLFIRI-cetuximab, followed by oxaliplatin-based second-line chemotherapy with bevacizumab (Arm A) vs. first-line OPTIMOX-bevacizumab, followed by irinotecan-based second-line chemotherapy with bevacizumab, and by an anti-epidermal growth factor receptor monoclonal antibody with or without irinotecan as third-line treatment (Arm B). The primary endpoint is duration of disease control. A total of 500 patients will be randomized in a 1:1 ratio to one of the two treatment strategies. The STRATEGIC-1 trial is designed to give global information on the therapeutic sequences in patients with unresectable RAS wild-type mCRC that in turn is likely to have a significant impact on the management of this patient population. The trial is open for inclusion since August 2013. STRATEGIC-1 is registered at Clinicaltrials.gov: NCT01910610, 23 July, 2013

  17. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study

    PubMed Central

    Slovin, S. F.; Higano, C. S.; Hamid, O.; Tejwani, S.; Harzstark, A.; Alumkal, J. J.; Scher, H. I.; Chin, K.; Gagnier, P.; McHenry, M. B.; Beer, T. M.

    2013-01-01

    Background This phase I/II study in patients with metastatic castration-resistant prostate cancer (mCRPC) explored ipilimumab as monotherapy and in combination with radiotherapy, based on the preclinical evidence of synergistic antitumor activity between anti-CTLA-4 antibody and radiotherapy. Patients and methods In dose escalation, 33 patients (≥6/cohort) received ipilimumab every 3 weeks × 4 doses at 3, 5, or 10 mg/kg or at 3 or 10 mg/kg + radiotherapy (8 Gy/lesion). The 10-mg/kg cohorts were expanded to 50 patients (ipilimumab monotherapy, 16; ipilimumab + radiotherapy, 34). Evaluations included adverse events (AEs), prostate-specific antigen (PSA) decline, and tumor response. Results Common immune-related AEs (irAEs) among the 50 patients receiving 10 mg/kg ± radiotherapy were diarrhea (54%), colitis (22%), rash (32%), and pruritus (20%); grade 3/4 irAEs included colitis (16%) and hepatitis (10%). One treatment-related death (5 mg/kg group) occurred. Among patients receiving 10 mg/kg ± radiotherapy, eight had PSA declines of ≥50% (duration: 3–13+ months), one had complete response (duration: 11.3+ months), and six had stable disease (duration: 2.8–6.1 months). Conclusions In mCRPC patients, ipilimumab 10 mg/kg ± radiotherapy suggested clinical antitumor activity with disease control and manageable AEs. Two phase III trials in mCRPC patients evaluating ipilimumab 10 mg/kg ± radiotherapy are ongoing. ClinicalTrials.gov identifier: NCT00323882. PMID:23535954

  18. On the metallicity of open clusters. III. Homogenised sample

    NASA Astrophysics Data System (ADS)

    Netopil, M.; Paunzen, E.; Heiter, U.; Soubiran, C.

    2016-01-01

    Context. Open clusters are known as excellent tools for various topics in Galactic research. For example, they allow accurately tracing the chemical structure of the Galactic disc. However, the metallicity is known only for a rather low percentage of the open cluster population, and these values are based on a variety of methods and data. Therefore, a large and homogeneous sample is highly desirable. Aims: In the third part of our series we compile a large sample of homogenised open cluster metallicities using a wide variety of different sources. These data and a sample of Cepheids are used to investigate the radial metallicity gradient, age effects, and to test current models. Methods: We used photometric and spectroscopic data to derive cluster metallicities. The different sources were checked and tested for possible offsets and correlations. Results: In total, metallicities for 172 open cluster were derived. We used the spectroscopic data of 100 objects for a study of the radial metallicity distribution and the age-metallicity relation. We found a possible increase of metallicity with age, which, if confirmed, would provide observational evidence for radial migration. Although a statistical significance is given, more studies are certainly needed to exclude selection effects, for example. The comparison of open clusters and Cepheids with recent Galactic models agrees well in general. However, the models do not reproduce the flat gradient of the open clusters in the outer disc. Thus, the effect of radial migration is either underestimated in the models, or an additional mechanism is at work. Conclusions: Apart from the Cepheids, open clusters are the best tracers for metallicity over large Galactocentric distances in the Milky Way. For a sound statistical analysis, a sufficiently large and homogeneous sample of cluster metallicities is needed. Our compilation is currently by far the largest and provides the basis for several basic studies such as the statistical

  19. REORIENTATION--"THE OPEN BOAT." LITERATURE CURRICULUM III, STUDENT VERSION.

    ERIC Educational Resources Information Center

    CRANE, STEPHEN; KITZHABER, ALBERT R.

    A SHORT STORY, STEPHEN CRANE'S "THE OPEN BOAT," AND SUGGESTIONS FOR STUDY OF THE STORY WERE PRESENTED IN A STUDY GUIDE, ONE OF A SERIES OF CURRICULUM GUIDES PRODUCED FOR USE BY A NINTH-GRADE ENGLISH CLASS. ONE STUDY TECHNIQUE PRESENTED, CALLED "THE EXPLODED DIAGRAM," INVOLVED SEPARATING THE STORY'S CONTENT INTO SUCH SINGLE…

  20. Salter-Harris Type III and IV medial malleolar fractures: growth arrest: is it a fate? A retrospective study of 48 cases with open reduction.

    PubMed

    Cottalorda, Jérôme; Béranger, Vincent; Louahem, Djamel; Camilleri, Jean Philippe; Launay, Franck; Diméglio, Alain; Bourelle, Sophie; Jouve, Jean-Luc; Bollini, Gérard

    2008-09-01

    Salter-Harris type III and IV medial malleolar fractures (MacFarland fracture) is a joint fracture of the ankle in children. The fracture line passes through the medial part of the lower epiphyseal disk of the tibia. Prognosis is dominated by later risk of misalignment and osteoarthritis. The aim of this study was to evaluate the functional and radiological outcome of these fractures. We retrospectively analyzed the cases of 48 children with MacFarland fractures (31 boys and 17 girls), mean age at the time of trauma 11 years 6 months (range, 8-15 years). The fractures were classed into two groups according to the Salter and Harris classification for epiphyseal detachment: Salter III (30 cases) and Salter IV (18 cases). Surgical treatment was given in all cases (46 screw fixations, 2 pin fixations). Three outcome categories were used: good (no pain, no stiffness, no limp, no misalignment, no surgical complication, no healing problem), fair (pain and/or stiffness and/or limp and/or healing problem without misalignment, no surgical complication), and poor (misalignment or surgical complication). Mean follow-up was 3 years and 3 months (24-94 months). Twenty-eight children were skeletally mature at the longest follow-up. The three-month postoperative assessment showed 35 patients with good results and 13 children with fair results. Ankle stiffness was noted in 6 cases, ankle pain in 4 cases, wound healing complications in 4 cases, limp in 1 case, and snapping in 1 case. The long-term outcome was considered good for 45 patients, fair for 2 patients (1 wound adherence and 1 hypertrophic scar tissue), and poor for 1 patient (6-degree varus deformity). We did not note leg-length discrepancy or malunion at the longest follow-up. Our results show that growth arrest after MacFarland fracture is no fate. We used surgery more than is generally reported by other teams, opting for surgery as soon as the displacement was >or=1 mm. Surgical treatment was arthrotomy in all cases to

  1. Long-term treatment of Cushing's disease with pasireotide: 5-year results from an open-label extension study of a Phase III trial.

    PubMed

    Petersenn, S; Salgado, L R; Schopohl, J; Portocarrero-Ortiz, L; Arnaldi, G; Lacroix, A; Scaroni, C; Ravichandran, S; Kandra, A; Biller, B M K

    2017-07-01

    Treating hypercortisolism in patients with Cushing's disease after failed surgery often requires chronic medication, underlining the need for therapies with favourable long-term efficacy and safety profiles. In a randomised, double-blind study, 162 adult patients with persistent/recurrent or de novo Cushing's disease received pasireotide. Patients with mean urinary free cortisol at/below the upper limit of normal or clinical benefit at month 12 could continue receiving pasireotide during an open-ended, open-label phase, the outcomes of which are described herein. Sixteen patients received 5 years of pasireotide treatment. Among these, median (95% confidence interval) percentage change from baseline in mean urinary free cortisol was -82.6% (-89.0, -41.9) and -81.8% (-89.8, -67.4) at months 12 and 60. Eleven patients had mean urinary free cortisol ≤ upper limit of normal at month 60. Improvements in clinical signs were sustained during long-term treatment. The safety profile of pasireotide at 5 years was similar to that reported after 12 months. Fifteen of 16 patients experienced a hyperglycaemia-related adverse event; glycated haemoglobin levels were stable between months 6 and 60. Adverse events related to hyperglycaemia, bradycardia, gallbladder/biliary tract, and liver safety were most likely to first occur by month 6; adverse event severity did not tend to worsen over time. This represents the longest prospective trial of a medical therapy for Cushing's disease to date. A subset of patients treated with pasireotide maintained biochemical and clinical improvements for 5 years, with no new safety signals emerging. These data support the use of pasireotide as an effective long-term therapy for some patients with Cushing's disease.

  2. SDSS-III/APOGEE: Science and Survey Calibrations and using Open Clusters

    NASA Astrophysics Data System (ADS)

    Frinchaboy, Peter M.; O'Connell, J.; Meszaros, Sz.; Cunha, K. M.; Smith, V. V.; Garcia Perez, A.; Shetrone, M. D.; Allende Prieto, C.; Johnson, J.; Zasowski, G.; Majewski, S. R.; Schiavon, R. P.; Holtzman, J. A.; Nidever, D.; Bizyaev, D.; Hearty, F. R.; Jackson, K.; Thompson, B. A.; Wilson, J. C.; Beers, T. C.

    2013-01-01

    We present results from the first year of the SDSS-III/Apache Point Obseratory Galactic Evolution Experiment (APOGEE) survey of open cluster targets. APOGEE is studying several key open clusters for calibration and science (e.g., M67, NGC 6791), and here we present early science results and comparison to previous work on a number of clusters focusing on radial velocities, stellar parameters, and abundances. Funding for SDSS-III has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the National Science Foundation, and the U.S. Department of Energy Office of Science. The SDSS-III web site is http://www.sdss3.org/. SDSS-III is managed by the Astrophysical Research Consortium for the Participating Institutions of the SDSS-III Collaboration including the University of Arizona, the Brazilian Participation Group, Brookhaven National Laboratory, University of Cambridge, Carnegie Mellon University, University of Florida, the French Participation Group, the German Participation Group, Harvard University, the Instituto de Astrofisica de Canarias, the Michigan State/Notre Dame/JINA Participation Group, Johns Hopkins University, Lawrence Berkeley National Laboratory, Max Planck Institute for Astrophysics, Max Planck Institute for Extraterrestrial Physics, New Mexico State University, New York University, Ohio State University, Pennsylvania State University, University of Portsmouth, Princeton University, the Spanish Participation Group, University of Tokyo, University of Utah, Vanderbilt University, University of Virginia, University of Washington, and Yale University.

  3. LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study.

    PubMed

    Ueno, Tatsuya; Sasaki, Megumi; Nishijima, Haruo; Funamizu, Yukihisa; Kon, Tomoya; Haga, Rie; Arai, Akira; Suzuki, Chieko; Nunomura, Jin-Ichi; Baba, Masayuki; Tomiyama, Masahiko

    2017-01-01

    The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the "on" time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the "off" state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off.

  4. Medial Spike and Obesity Associate with Open Reduction in Type III Supracondylar Humeral Fracture.

    PubMed

    Çabuk, H; Dedeoğlu, S S; Adaş, M; Tekin, A Ç; Seyran, M; Ayanoğlu, S

    2016-01-01

    PURPOSE OF THE STUDY Although supracondylar humeral fractures represent a major part of the pediatric fractures, no classification system or radiological characteristics describes which supracondylar fractures require open reduction. We aim to evaluate the factors that lead us to perform open reduction during operation. MATERIAL AND METHODS We retrospectively evaluated 57 patients who underwent operation for type III supracondylar fracture, and divided them into two groups; those with open reduction and internal fixation, and those with closed reduction and percutaneous fixation. The two groups were compared based on age, gender, BMI by age, medial spike angle of the fracture, medial spike-skin distance and rotation angle between the fractured fragments. RESULTS Of all patients, 46 (81.71%) underwent closed reduction and percutaneous fixation (CRPF) and 11 (19.29%) were treated with open reduction and internal fixation (ORIF). BMI by age was remarkably higher in the ORIF group (p = 0.00). And medial spike angle was smaller in the ORIF group (p = 0.014). DISCUSSION Closed reduction and percutanous fixation is the main treatment of supracondylar humeral fractuers. Open reduction in supracondylar humeral fractures could be associate with complications and cosmetic lesions. Many studies indicates that obesity is high risk factor for complex fractures as well as preoperative and postoperative complications. A prominant medial spike could associate with muscle entrapment, and obliquity of the fracture line. It could be also an indirect finding of instablity of the fracture. CONCLUSION We suggest that a smaller medial spike angle and a higher BMI in children with Type III supracondylar humeral fractures may require open reduction, and it is unreasonable to avoid open reduction in cases where closed reduction is not achieved. supracondylar humerus, open reduction, obesity, medial spike angle.

  5. LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study

    PubMed Central

    Sasaki, Megumi; Nishijima, Haruo; Funamizu, Yukihisa; Kon, Tomoya; Haga, Rie; Arai, Akira; Suzuki, Chieko; Nunomura, Jin-ichi; Baba, Masayuki; Tomiyama, Masahiko

    2017-01-01

    The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the “on” time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the “off” state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off. PMID:28255499

  6. Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: Long-term efficacy and safety results from 2 randomized phase-III studies and 1 open-label long-term extension study.

    PubMed

    Papp, Kim A; Krueger, James G; Feldman, Steven R; Langley, Richard G; Thaci, Diamant; Torii, Hideshi; Tyring, Stephen; Wolk, Robert; Gardner, Annie; Mebus, Charles; Tan, Huaming; Luo, Yingchun; Gupta, Pankaj; Mallbris, Lotus; Tatulych, Svitlana

    2016-05-01

    Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. We sought to report longer-term tofacitinib efficacy and safety in patients with moderate to severe psoriasis. Data from 2 identical phase-III studies, Oral-treatment Psoriasis Trial Pivotal 1 and 2, were pooled with data from these patients in an ongoing open-label long-term extension study. Patients (n = 1861) were randomized 2:2:1 to tofacitinib 5 mg, 10 mg, or placebo twice daily (BID). At week 16, placebo patients were rerandomized to tofacitinib. Pivotal study participants could enroll into the long-term extension where they received tofacitinib at 10 mg BID for 3 months, after which dosing could be 5 or 10 mg BID. At week 28, the proportions of patients randomized to tofacitinib 5 and 10 mg BID achieving 75% or greater reduction in Psoriasis Area and Severity Index score from baseline were 55.6% and 68.8%, and achieving Physician Global Assessment of clear or almost clear were 54.7% and 65.9%. Efficacy was maintained in most patients through 24 months. Serious adverse events and discontinuations because of adverse events were reported in less than 11% of patients over 33 months of tofacitinib exposure. There was no dose comparison beyond week 52. Oral tofacitinib demonstrated sustained efficacy in patients with psoriasis through 2 years, with 10 mg BID providing greater efficacy than 5 mg BID. No unexpected safety findings were observed. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  7. Efficacy and safety of Privigen® in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study)

    PubMed Central

    Léger, Jean-Marc; De Bleecker, Jan L; Sommer, Claudia; Robberecht, Wim; Saarela, Mika; Kamienowski, Jerzy; Stelmasiak, Zbigniew; Mielke, Orell; Tackenberg, Björn; Shebl, Amgad; Bauhofer, Artur; Zenker, Othmar; Merkies, Ingemar S J

    2013-01-01

    This prospective, multicenter, single-arm, open-label Phase III study aimed to evaluate the efficacy and safety of Privigen® (10% liquid human intravenous immunoglobulin [IVIG], stabilized with l-proline) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Patients received one induction dose of Privigen (2 g/kg body weight [bw]) and up to seven maintenance doses (1 g/kg bw) at 3-week intervals. The primary efficacy endpoint was the responder rate at completion, defined as improvement of ≥1 point on the adjusted Inflammatory Neuropathy Cause and Treatment (INCAT) disability scale. The preset success criterion was the responder rate being ≥35%. Of the 31 screened patients, 28 patients were enrolled including 13 (46.4%) IVIG-pretreated patients. The overall responder rate at completion was 60.7% (95% confidence interval [CI]: 42.41%–76.43%). IVIG-pretreated patients demonstrated a higher responder rate than IVIG-naïve patients (76.9% vs. 46.7%). The median (25%–75% quantile) INCAT score improved from 3.5 (3.0–4.5) points at baseline to 2.5 (1.0–3.0) points at completion, as did the mean (standard deviation [SD]) maximum grip strength (66.7 [37.24] kPa vs. 80.9 [31.06] kPa) and the median Medical Research Council sum score (67.0 [61.5–72.0] points vs. 75.5 [71.5–79.5] points). Of 108 adverse events (AEs; 0.417 AEs per infusion), 95 AEs (88.0%) were mild or moderate in intensity and resolved by the end of study. Two serious AEs of hemolysis were reported that resolved after discontinuation of treatment. Thus, Privigen provided efficacious and well-tolerated induction and maintenance treatment in patients with CIDP. PMID:23781960

  8. Blue stragglers in open clusters. III. NGC 7789

    NASA Astrophysics Data System (ADS)

    Schönberner, D.; Andrievsky, S. M.; Drilling, J. S.

    2001-02-01

    We performed for the first time a detailed LTE spectroscopic study of a sample of blue straggler stars in the moderately old open cluster NGC 7789. For eight stars the parameters and abundances of several elements were determined. The cluster members show a remarkable surface magnesium deficiency which is quite unusual for late B - early A stars. Iron and titanium abundances are in agreement with other photometric and spectroscopic estimates of the NGC 7789 metallicity. All the confirmed blue stragglers have rather low projected rotational velocities (with one exception for K88, vsin i = 80 km s-1). Based on the spectra collected at Kitt Peak National Observatory, operated by the Association of Universities for Research in Astronomy, Inc., under contract with the National Science Foundation, and at the German-Spanish Astronomical Center, Calar Alto, operated by the Max-Plank Institute for Astronomy, Heidelberg, jointly with the Spanish National Commission for Astronomy.}

  9. Infectious Complications of Open Type III Tibial Fractures among Combat Casualties

    DTIC Science & Technology

    2007-08-15

    Infection of Combat-Related Fractures • CID 2007:45 (15 August) • 409 M A J O R A R T I C L E Infectious Complications of Open Type III Tibial...associated with high-energy explosive injuries, often resulting in open tibial fractures complicated by nonunion and infection . We characterize the... infections seen in conjunction with combat-associated type III tibial fractures. Methods. We performed a retrospective medical records review to identify US

  10. Efficacy and safety of Privigen(®) in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study).

    PubMed

    Léger, Jean-Marc; De Bleecker, Jan L; Sommer, Claudia; Robberecht, Wim; Saarela, Mika; Kamienowski, Jerzy; Stelmasiak, Zbigniew; Mielke, Orell; Tackenberg, Björn; Shebl, Amgad; Bauhofer, Artur; Zenker, Othmar; Merkies, Ingemar S J

    2013-06-01

    This prospective, multicenter, single-arm, open-label Phase III study aimed to evaluate the efficacy and safety of Privigen(®) (10% liquid human intravenous immunoglobulin [IVIG], stabilized with L-proline) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Patients received one induction dose of Privigen (2 g/kg body weight [bw]) and up to seven maintenance doses (1 g/kg bw) at 3-week intervals. The primary efficacy endpoint was the responder rate at completion, defined as improvement of ≥1 point on the adjusted Inflammatory Neuropathy Cause and Treatment (INCAT) disability scale. The preset success criterion was the responder rate being ≥35%. Of the 31 screened patients, 28 patients were enrolled including 13 (46.4%) IVIG-pretreated patients. The overall responder rate at completion was 60.7% (95% confidence interval [CI]: 42.41%-76.43%). IVIG-pretreated patients demonstrated a higher responder rate than IVIG-naïve patients (76.9% vs. 46.7%). The median (25%-75% quantile) INCAT score improved from 3.5 (3.0-4.5) points at baseline to 2.5 (1.0-3.0) points at completion, as did the mean (standard deviation [SD]) maximum grip strength (66.7 [37.24] kPa vs. 80.9 [31.06] kPa) and the median Medical Research Council sum score (67.0 [61.5-72.0] points vs. 75.5 [71.5-79.5] points). Of 108 adverse events (AEs; 0.417 AEs per infusion), 95 AEs (88.0%) were mild or moderate in intensity and resolved by the end of study. Two serious AEs of hemolysis were reported that resolved after discontinuation of treatment. Thus, Privigen provided efficacious and well-tolerated induction and maintenance treatment in patients with CIDP. © 2013 The Authors. Journal of the Peripheral Nervous System published by Wiley Periodicals, Inc. on behalf of Peripheral Nerve Society.

  11. Efficacy and safety of tolvaptan in heart failure patients with sustained volume overload despite the use of conventional diuretics: a phase III open-label study.

    PubMed

    Fukunami, Masatake; Matsuzaki, Masunori; Hori, Masatsugu; Izumi, Tohru

    2011-12-01

    Volume overload is a common complication associated with heart failure (HF) and is recommended to be treated with loop or thiazide diuretics. However, use of diuretics can cause serum electrolyte imbalances and diuretic resistance. Tolvaptan, a selective, oral, non-peptide vasopressin V2-receptor antagonist, offers a new option for treating volume overload in HF patients. The aim of this study was to investigate the efficacy and safety of tolvaptan in Japanese HF patients with volume overload. Fifty-one HF patients with volume overload, despite using conventional diuretics, were treated with 15 mg/day tolvaptan for 7 days. If the response was insufficient at Day 7, tolvaptan was continued for a further 7 days at either 15 mg/day or 30 mg/day. Outcomes included changes in body weight, symptoms and safety parameters. Thirty-six patients discontinued treatment within 7 days, therefore 15 patients entered the second phase of treatment. In two patients, tolvaptan was increased to 30 mg/day after 7 days. Body weight was reduced on Day 7 (-1.95 ± 1.98 kg; n = 41) and Day 14 (-2.35 ± 1.44 kg; n = 11, 15 mg/day). Symptoms of volume overload, including lower limb edema, pulmonary congestion, jugular venous distention and hepatomegaly, were improved by tolvaptan treatment for 7 or 14 days. Neither tolvaptan increased the incidence of severe or serious adverse events when administered for 7-14 days. This study confirms the efficacy and safety of 15 mg/day tolvaptan for 7-14 days in Japanese HF patients with volume overload despite conventional diuretics.

  12. REORIENTATION--"THE OPEN BOAT." LITERATURE CURRICULUM III, TEACHER VERSION.

    ERIC Educational Resources Information Center

    CRANE, STEPHEN; KITZHABER, ALBERT R.

    IN THIS TEACHER'S GUIDE FOR NINTH-GRADE ENGLISH CLASSES, AN APPROACH TO THE ANALYSIS OF STEPHEN CRANE'S "THE OPEN BOAT" WAS OUTLINED. THE APPROACH EMPHASIZED DEVELOPMENT OF STUDENT UNDERSTANDING OF THE STORY'S SUBJECT, FORM, AND POINT-OF-VIEW. THIS APPROACH INCORPORATED THE PRINCIPLES OF ANALYSIS OF LITERATURE THAT WERE INTRODUCED IN THE…

  13. [Meaning of living with external fixation for grade III open fracture of lower limbs: patient view].

    PubMed

    Lopez, Catia Cristina Gomes; Gamba, Mônica Antar; Matheus, Maria Clara Cassuli

    2013-06-01

    The present study is aimed to understand the meaning of living with an external fixation device for grade III open fractures of the lower limbs from the perspective of the patient. The data were collected with six young adults who were undergoing outpatient orthopedic treatment in a public hospital in the city of São Paulo, through semi-structured interviews with open questions, between June and August 2010. Seeking to understand the meaning of this experience, we have maintained a phenomenological attitude during the analysis, which made it possible to reveal the phenomenon "try to live in spite of feeling trapped in a cage." Patients said that their personal desire and support from others helped them reorganize their lives, despite the several challenges they had to overcome to adapt to the fastener attached to their body and the fear of the future and doubts about the success of treatment.

  14. [Effect of Negative Pressure Wound Therapy on Infectious Complications in Grade III Open Fractures].

    PubMed

    Krtička, M; Ira, D; Nekuda, V; Švancara, J; Mašek, M

    2016-01-01

    PURPOSE OF THE STUDY Grade III open fractures are associated with infectious complications in 25-66% of injuries. Negative pressure wound therapy (NPWT) applied to an injured soft tissue coverage provides an impermeable barrier between the injured structures and the external environment, in addition to early secretion draining and a positive effect on the site of application. All this also prevents secondary bacterial contamination. The objective of the study was to compare the results of treatment methods in view of infectious complications in patients with soft tissue injury in grade-III open fractures managed either by NPWT and primary closure or by covering with combined dressing fabric (COM) in combination with continual wound lavage. MATERIAL AND METHODS This retrospective study comprised 77 patients with 80 grade III open fractures treated in the years 2008-2012; of these, 39 patients with 41 fractures met the inclusion criteria and were finally evaluated. The patients were divided into two groups. The control group included 19 patients with 20 fractures treated by the standard surgical procedure using stabilisation with an external fixator or intramedullary nail, thorough soft tissue debridement, continual wound lavage and suture of skin lesions or using a primary coverage of the defect with COM. The trial group consisted of 20 patients with 21 fractures treated according to the same principle, but NPWT was applied to injured soft tissue coverage first and skin suture or any other type of skin defect coverage was carried out when the healing process was good and bacteriological findings were negative. The results of both methods were evaluated based on the following criteria: development of superficial or deep infection in the wound, interval to negative bacteriological findings and osteomyelitis rate. The results were analysed by Fisher's exact test and the Man Whitney U test. RESULTS Infectious complications were recorded in a total of 15 (37%) fractures

  15. Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013).

    PubMed

    Watanabe, Kazuhiro; Shimo, Arata; Tsugawa, Kouichiro; Tokuda, Yutaka; Yamauchi, Hideko; Miyai, Eriko; Takemura, Kimitoshi; Ikoma, Akihiko; Nakamura, Seigo

    2016-06-01

    Malignant fungating tumors are neoplastic tumors associated with skin ulcers, which are susceptible to microbial colonization. Bacterial infection and proliferation may lead to malodor causing distress to patients. Metronidazole-an effective agent against anaerobes-may contribute to deodorization and improvement in quality of life (QOL). This study investigated the efficacy and safety of topical metronidazole 0.75 % gel for alleviation of malodor in anaerobically infected fungating neoplastic tumors. This was a multicenter, open-label, non-controlled, phase III study including subjects aged 20 years or older with cutaneous fungating tumors releasing malodor (minimum score of 2 (mildly offensive smell) on a scale from 0 (no smell) to 4 (extremely offensive smell) based on investigator's assessment). Subjects applied metronidazole 0.75 % gel once or twice daily at the investigator's discretion for 14 days. Success was defined as an odor score of 0 or 1 at day 14, as assessed by the investigator. Patient satisfaction was assessed using a satisfaction questionnaire. Adverse events (AEs) that occurred after application of metronidazole 0.75 % gel were also reported. A total of 21 subjects at a median age of 65.0 years were enrolled. The success rate of deodorization at day 14 was 95.2 % (20/21 subjects). The patient satisfaction assessment showed that 71.4 % (15/21) of subjects were markedly or moderately improved. The treatment was well tolerated with only two AE cases of skin neoplasm bleeding (one mild and one moderate). Metronidazole 0.75 % gel is an effective and safe treatment for deodorization of malodorous fungating tumors.

  16. Deferiprone (GPO-L-ONE(®) ) monotherapy reduces iron overload in transfusion-dependent thalassemias: 1-year results from a multicenter prospective, single arm, open label, dose escalating phase III pediatric study (GPO-L-ONE; A001) from Thailand.

    PubMed

    Viprakasit, Vip; Nuchprayoon, Issarang; Chuansumrit, Ampaiwan; Torcharus, Kitti; Pongtanakul, Bunchoo; Laothamatas, Jiraporn; Srichairatanakool, Somdet; Pooliam, Julaporn; Supajitkasem, Siriwat; Suriyaphol, Prapat; Tanphaichitr, Voravarn S; Tuchinda, Soodsarkorn

    2013-04-01

    Accessibility to iron chelators including deferoxamine and deferasirox remains obscured in many developing countries. To provide an alternative, the government pharmaceutical organization of Thailand (GPO) manufactured deferiprone which has similar bioequivalent to the standard product. Seventy-three pediatric patients with severe β thalassemias, age range 3.2-19 years, were recruited to a 1-year multicenter prospective, single arm, open label, dose escalating Phase III study of deferiprone to determine its clinical efficacy and safety. Sixty-four patients (87.6%) completed the study with good compliance (>94%). Average deferiprone dose was 79.1±4.3 mg/kg/day. Overall, mean serum ferritin (SF) levels at 1 year were not significantly changed from baseline. However, 45% of patients (response group) had SF reduced >15% from baseline at 1 year with a median reduction of 1,065 ng ml(-1) . Baseline SF was the major factor that predicts clinical efficacy; patients with baseline SF>3,500 ng ml(-1) had the most significant fall of SF at 1 year. A subgroup analysis by MRI-T2* confirmed that the response group had higher baseline liver iron and deferiprone could significantly reduce liver iron overload and normalize levels of ALT at 1 year. Although, gastrointestinal irritation (20.5%) was the most common drug-related adverse events (AEs) followed by transaminitis (16.4%) and neutropenia (6.8%), all patients were well tolerated. There was no mortality and agranulocytosis found in this trial. Monotherapy of deferiprone with appropriate dose adjustment and monitoring for adverse events appeared to be an effective chelation therapy in some patients with good compliance and acceptable safety profiles. Copyright © 2013 Wiley Periodicals, Inc.

  17. Simeprevir in combination with sofosbuvir in treatment-naïve and -experienced patients with hepatitis C virus genotype 4 infection: a Phase III, open-label, single-arm study (PLUTO).

    PubMed

    Buti, M; Calleja, J L; Lens, S; Diago, M; Ortega, E; Crespo, J; Planas, R; Romero-Gómez, M; Rodríguez, F G; Pascasio, J M; Fevery, B; Kurland, D; Corbett, C; Kalmeijer, R; Jessner, W

    2017-02-01

    Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and subsequent hepatocellular carcinoma. HCV genotype 4 is found widely in the Middle East, Egypt and Africa, and has also spread into Europe. There are limited data available regarding the use of direct-acting antiviral agents in HCV genotype 4-infected patients with cirrhosis. To evaluate in the phase III, open-label, single-arm PLUTO study the efficacy and safety of 12 weeks of simeprevir (HCV NS3/4A protease inhibitor) plus sofosbuvir (HCV nucleotide-analogue NS5B polymerase inhibitor) in treatment-naïve and (peg)interferon ± ribavirin-experienced HCV genotype 4-infected patients, with or without compensated cirrhosis. Adult patients with chronic HCV genotype 4 infection received simeprevir 150 mg once-daily and sofosbuvir 400 mg once-daily for 12 weeks. The primary efficacy endpoint was sustained virologic response 12 weeks after the end of treatment (SVR12). Safety was also assessed. Forty patients received treatment; the majority were male (73%) and treatment-experienced (68%). Overall, 7/40 (18%) patients had compensated cirrhosis. All patients achieved SVR12 [100% (Clopper-Pearson 95% confidence interval: 91-100%)]. Adverse events, all Grade 1 or 2, were reported in 20/40 (50%) patients. No serious adverse events were reported and no patients discontinued study treatment. Grade 3 treatment-emergent laboratory abnormalities were noted in 2/40 (5%) patients. Treatment with simeprevir plus sofosbuvir for 12 weeks resulted in SVR12 rates of 100% in treatment-naïve and -experienced patients with HCV genotype 4 infection with or without compensated cirrhosis, and was well tolerated. [NCT02250807]. © 2016 John Wiley & Sons Ltd.

  18. Efficacy and safety of daclatasvir plus pegylated-interferon alfa 2a and ribavirin in previously untreated HCV subjects coinfected with HIV and HCV genotype-1: a Phase III, open-label study.

    PubMed

    Sulkowski, Mark S; Fessel, Walford J; Lazzarin, Adriano; Berenguer, Juan; Zakharova, Natalia; Cheinquer, Hugo; Côté, Pierre; Dieterich, Douglas; Gadano, Adrian; Matthews, Gail; Molina, Jean-Michel; Moreno, Christophe; Pineda, Juan Antonio; Pulido, Federico; Rivero, Antonio; Rockstroh, Jurgen; Hernandez, Dennis; McPhee, Fiona; Eley, Timothy; Liu, Zhaohui; Mendez, Patricia; Hughes, Eric; Noviello, Stephanie; Ackerman, Peter

    2017-03-01

    Daclatasvir (DCV) is a potent, pangenotypic, hepatitis C virus (HCV) non-structural protein 5A inhibitor with low potential for drug interactions with antiretroviral therapy (ART). We evaluated the safety and efficacy of DCV plus peginterferon alfa-2a/ribavirin (PegIFN/RBV) in HIV-1/HCV genotype-1-coinfected patients. AI444043 (NCT01471574), an open-label, Phase III, single-arm, response-guided treatment (RGT) study included 301 patients. They received DCV doses of 30, 60 or 90 mg once daily (depending on concomitant ART), plus weight-based RBV (<75 kg, 1000 mg/day; or ≥75 kg, 1200 mg/day), and once-weekly PegIFN 180 μg, for 24 weeks. If required by RGT, PegIFN/RBV without DCV was extended for an additional 24 weeks of therapy. The primary endpoint was the proportion of patients with sustained virologic response at post-treatment Week 12 (SVR12). Overall, 224 (74%) patients achieved SVR12 and the lower bound of the 95% confidence interval was higher than the historic SVR rate with PegIFN/RBV alone (70 vs. 29%). Most common adverse events (AEs) were fatigue, neutropenia, anemia, asthenia and headache. On-treatment serious AEs occurred in 24/301 (8%) patients; 18/301 (6%) discontinued treatment due to AE. DCV + PegIFN/RBV led to sustained HCV virologic response in the majority of HIV-1-HCV-coinfected patients, regardless of concomitant ART. HIV control was not compromised and no new safety signals were identified. This study supports DCV use in HIV-1-HCV-coinfected patients, while allowing the vast majority of patients to remain on their existing ART regimen.

  19. Open Entry/Open Exit Study. Final Report.

    ERIC Educational Resources Information Center

    Berg, Marvin

    Open entry/open exit refers to formats and procedures which allow learners to enter a program whenever they are ready and available, and allows them to leave or complete programs when competencies for job entry are attained. This study sought to provide base data on the concept of open entry/open exit by surveying involved individuals and to…

  20. Field studies courses open

    NASA Astrophysics Data System (ADS)

    Fourteen month-long courses combining applied academics with training in field research methodology are being offered this summer by the School for Field Studies. The courses, held in eight countries during May, June, July, and August, provide unique opportunities for participants to work as a team under primitive conditions.‘Our courses bind together the academic challenge of the research problem, the physical challenge of the site itself, and the interpersonal challenge of the expedition team in a dynamic way so that both cognitive and affective learning are accelerated,’ according to Jim Elder, the school's director.

  1. A Qualitative Study of Recovery from Type III-B and III-C Tibial Fractures

    PubMed Central

    Shauver, Melissa S.; Aravind, Maya S.; Chung, Kevin C.

    2011-01-01

    The literature has shown that long-term outcomes for both below-knee amputation and reconstruction following type III-B and III-C tibial fracture are poor. Yet, patients often report satisfaction with their treatment and/or outcomes. The aim of this study is to explore the relationship between patient outcomes and satisfaction after open tibial fractures via qualitative methodology. Twenty patients who were treated for open tibial fractures at one institution were selected using purposeful sampling and interviewed in-person in a semi-structured manner. Data were analyzed using grounded theory methodology. Despite reporting marked physical and psychosocial deficits, participants relayed high satisfaction. We hypothesize that the use adaptive coping techniques successfully reduces stress, which leads to an increase in coping self-efficacy that results in the further use of adaptive coping strategies, culminating in personal growth. This stress reduction and personal growth leads to satisfaction despite poor functional and emotional outcomes. PMID:20948418

  2. A Multicenter, Open Labeled, Randomized, Phase III Study Comparing Lopinavir/Ritonavir Plus Atazanavir to Lopinavir/Ritonavir Plus Zidovudine and Lamivudine in Naive HIV-1-Infected Patients: 48-Week Analysis of the LORAN Trial

    PubMed Central

    Ulbricht, K.U; Behrens, G.M; Stoll, M; Salzberger, B; Jessen, H; Jessen, A.B; Kuhlmann, B; Heiken, H; Trein, A; Schmidt, R.E

    2011-01-01

    Objective: The primary aim of the study was to compare the metabolic side effects of a nucleoside analogue-containing regimen with a nucleoside analogue-sparing double protease inhibitor regimen. A secondary goal was to test for efficacy of a double-PI regimen. Design: Multicenter, randomized, open-label, phase III clinical trial. Subjects: Adult HIV-1-infected individuals naïve to antiretroviral therapy with viral load above 400 HIV-RNA copies/ml were randomized (1:1) to either 400 mg lopinavir /100 mg ritonavir (LPV/r) BID plus 150 mg lamivudine/300 mg zidovudine (CBV) BID versus LPV/r BID plus 300 mg atazanavir (ATV) QD. Main outcome measure was the virologic failure in both groups, defined as viral load ≥50 copies/ml at week 48. Results: In the CBV/LPV/r-arm, 29 out of 35 patients [(83%; 95% confidence interval (CI) 66.9-92.2%] and 18 out of 40 patients (45%; 95% CI 29.7-61.5%) in the ATV/LPV/r-arm had a HIV-RNA level <50 copies/ml at week 48. The intent-to-treat analysis revealed inferior virologic response in the ATV/LPV/r arm (Chi-Q and Fisher´s Exact Test p<0.001) and resulted in premature termination of the trial. Eleven patients in the ATV/LPV/r-arm discontinued therapy because of virological failure. These failures mostly presented with low level replication (<1,000 copies/ml). Increases in CD4 cell counts was significantly more rapid in the ATV/LPV/r arm (p=0.02), but comparable at week 48. Conclusions: ATV/LPV/r had less virologic efficacy than the conventional RTI-based regimen and resulted in a high virological failure rate with low level replication. PMID:21643422

  3. Development of opioid-induced constipation: post hoc analysis of data from a 12-week prospective, open-label, blinded-endpoint streamlined study in low-back pain patients treated with prolonged-release WHO step III opioids

    PubMed Central

    Ueberall, Michael A; Mueller-Schwefe, Gerhard HH

    2015-01-01

    Background Opioid-induced constipation is the most prevalent patient complaint associated with longer-term opioid use and interferes with analgesic efficacy, functionality, quality of life, and patient compliance. Objectives We aimed to compare the effects of prolonged-release (PR) oxycodone plus PR naloxone (OXN) vs PR oxycodone (OXY) vs PR morphine (MOR) on bowel function under real-life conditions in chronic low-back pain patients refractory to World Health Organization (WHO) step I and/or II analgesics. Research design and methods This was a post hoc analysis of the complete data set from a prospective, randomized, open-label, blinded endpoint (PROBE) streamlined study (German pain study registry: 2012-0012-05; European Union Drug Regulating Authorities Clinical Trials [EudraCT]: 2012-001317-16), carried out in 88 centers in Germany, where a total of 901 patients requiring WHO step III opioids to treat low-back pain were enrolled and prospectively observed for 3 months. Opioid allocation was based on either optional randomization (n=453) or physician decision (n=448). In both groups, treatment doses could be adjusted as per the German prescribing information, and physicians were free to address all side effects and tolerability issues as usual. The primary endpoint was the proportion of patients maintaining normal bowel function throughout the complete treatment period, assessed with the Bowel Function Index (BFI). Secondary analyses addressed absolute and relative BFI changes, complete spontaneous bowel movements, use of laxatives, treatment emergent adverse events, analgesic effects, and differences between randomized vs nonrandomized patient groups. Results BFI changed significantly with all three WHO step III treatments, however significantly less with OXN vs OXY and MOR despite a significantly higher use of laxatives with the latter ones (P<0.001). The percentage of patients who maintained normal BFI scores despite opioid treatment was 54.5% (164/301) with

  4. Tolerability of Biphasic-Release Hydrocodone Bitartrate/Acetaminophen Tablets (MNK-155): A Phase III, Multicenter, Open-Label Study in Patients With Osteoarthritis or Chronic Low Back Pain.

    PubMed

    Zheng, Yanping; Kostenbader, Kenneth; Barrett, Thomas; Hisaw, Elizabeth; Giuliani, Michael J; Chen, Yin; Young, Jim L

    2015-06-01

    This study aimed to assess the tolerability of the extended use (≤35 days) of MNK-155, a biphasic (immediate-release/extended-release) hydrocodone bitartrate/N-acetyl-p-aminophenol (acetaminophen) (IR/ER HB/APAP) 7.5/325-mg fixed-dose combination analgesic agent, in patients with chronic noncancer pain (CNCP) caused by osteoarthritis or chronic low back pain. IR/ER HB/APAP tablets deliver 25% of the HB dose and 50% of the APAP dose by IR and the remainder by ER over a 12-hour dosing interval. Although IR/ER HB/APAP is being developed for the management of moderate to severe acute pain, this model of CNCP was used for assessing tolerability over a term longer than would be possible in a model of acute pain. This Phase III, multicenter, open-label study enrolled patients with moderate to severe OA (knee or hip) pain despite the use of nonopioid or opioid analgesic agents, or with moderate to severe CLBP present for several hours per day for ≥3 months. Patients received a 3-tablet initial dose of IR/ER HB/APAP (total dose, 22.5/975 mg) on day 1, followed by 2 tablets of IR/ER HB/APAP (total dose, 15/650 mg) q12h for up to 35 days. Tolerability, the primary end point, was assessed using time to treatment discontinuation, the prevalence of treatment-emergent adverse events (TEAEs), vital sign measurements, pulse oximetry, clinical laboratory tests, and compliance. Secondary outcomes included the modified Brief Pain Inventory-Short Form, the Western Ontario and McMaster Universities Arthritis Index, and The Roland-Morris Low Back Pain and Disability Questionnaire. Of the 153 patients enrolled (95 women [62.1%]; mean age, 53.9 [14.5] years; OA, n = 73; CLBP, n = 80), 37 (24.2%) discontinued the study early (mean time to discontinuation, 21.3 days). Thirteen patients (8.5%) discontinued because of TEAEs. A total of 88 patients (57.5%) reported ≥1 TEAE, 65 (42.5%) of whom experienced AEs considered by the investigator as treatment related. The most frequent TEAEs were

  5. Lateral open bite and crossbite correction in a Class III patient with missing maxillary first premolars.

    PubMed

    Park, Jae Hyun; Yu, Joseph; Chae, Jong-Moon

    2017-07-01

    Posterior and Class III elastics were used to correct lateral open bite and anterior crossbite in a 29-year-old man. His occlusion, smile esthetics, and soft tissue profile were significantly improved after 25 months of active orthodontic treatment combined with 4 anterior restorations. Copyright © 2017 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  6. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter the...

  7. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter the...

  8. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter the...

  9. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter the...

  10. 30 CFR 57.22103 - Open flames (I-A, II-A, III, and V-A mines).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Open flames (I-A, II-A, III, and V-A mines). 57... Open flames (I-A, II-A, III, and V-A mines). Open flames shall not be permitted underground except for... I-A mine. When using open flames in other than fresh air, or in places where methane may enter the...

  11. Targeted simplification versus antipseudomonal broad-spectrum beta-lactams in patients with bloodstream infections due to Enterobacteriaceae (SIMPLIFY): a study protocol for a multicentre, open-label, phase III randomised, controlled, non-inferiority clinical trial.

    PubMed

    López-Cortés, Luis Eduardo; Rosso-Fernández, Clara; Núñez-Núñez, María; Lavín-Alconero, Lucía; Bravo-Ferrer, José; Barriga, Ángel; Delgado, Mercedes; Lupión, Carmen; Retamar, Pilar; Rodríguez-Baño, Jesús

    2017-06-09

    Within the context of antimicrobial stewardship programmes, de-escalation of antimicrobial therapy is one of the proposed strategies for reducing the unnecessary use of broad-spectrum antibiotics (BSA). The empirical treatment of nosocomial and some healthcare-associated bloodstream infections (BSI) frequently includes a beta-lactam with antipseudomonal activity as monotherapy or in combination with other drugs, so there is a great opportunity to optimise the empirical therapy based on microbiological data. De-escalation is assumed as standard of care for experts in infectious diseases. However, it is less frequent than it would desirable. The SIMPLIFY trial is a multicentre, open-label, non-inferiority phase III randomised controlled clinical trial, designed as a pragmatic 'real-practice' trial. The aim of this trial is to demonstrate the non-inferiority of de-escalation from an empirical beta-lactam with antipseudomonal activity to a targeted narrow-spectrum antimicrobial in patients with BSI due to Enterobacteriaceae. The primary outcome is clinical cure, which will be assessed at the test of cure visit. It will be conducted at 19 Spanish public and university hospitals. Each participating centre has obtained the approval of the ethics review committee, the agreement of the directors of the institutions and authorisation from the Spanish Regulatory Agency (Agencia Española del Medicamento y Productos Sanitarios). Data will be presented at international conferences and published in peer-reviewed journals. Strategies to reduce the use of BSA should be a priority. Most of the studies that support de-escalation are observational, retrospective and heterogeneous. A recent Cochrane review stated that well-designed clinical trials should be conducted to assess the safety and efficacy of de-escalation. The European Union Clinical Trials Register: EudraCT number 2015-004219-19. Clinical trials.gov: NCT02795949. Protocol version: V.2.0, dated 16 May 2016. All items from

  12. First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study.

    PubMed

    Wu, Y-L; Zhou, C; Liam, C-K; Wu, G; Liu, X; Zhong, Z; Lu, S; Cheng, Y; Han, B; Chen, L; Huang, C; Qin, S; Zhu, Y; Pan, H; Liang, H; Li, E; Jiang, G; How, S H; Fernando, M C L; Zhang, Y; Xia, F; Zuo, Y

    2015-09-01

    The phase III, randomized, open-label ENSURE study (NCT01342965) evaluated first-line erlotinib versus gemcitabine/cisplatin (GP) in patients from China, Malaysia and the Philippines with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). Patients ≥18 years old with histologically/cytologically confirmed stage IIIB/IV EGFR mutation-positive NSCLC and Eastern Cooperative Oncology Group performance status 0-2 were randomized 1:1 to receive erlotinib (oral; 150 mg once daily until progression/unacceptable toxicity) or GP [G 1250 mg/m(2) i.v. days 1 and 8 (3-weekly cycle); P 75 mg/m(2) i.v. day 1, (3-weekly cycle) for up to four cycles]. Primary end point: investigator-assessed progression-free survival (PFS). Other end points include objective response rate (ORR), overall survival (OS), and safety. A total of 217 patients were randomized: 110 to erlotinib and 107 to GP. Investigator-assessed median PFS was 11.0 months versus 5.5 months, erlotinib versus GP, respectively [hazard ratio (HR), 0.34, 95% confidence interval (CI) 0.22-0.51; log-rank P < 0.0001]. Independent Review Committee-assessed median PFS was consistent (HR, 0.42). Median OS was 26.3 versus 25.5 months, erlotinib versus GP, respectively (HR, 0.91, 95% CI 0.63-1.31; log-rank P = .607). ORR was 62.7% for erlotinib and 33.6% for GP. Treatment-related serious adverse events (AEs) occurred in 2.7% versus 10.6% of erlotinib and GP patients, respectively. The most common grade ≥3 AEs were rash (6.4%) with erlotinib, and neutropenia (25.0%), leukopenia (14.4%), and anemia (12.5%) with GP. These analyses demonstrate that first-line erlotinib provides a statistically significant improvement in PFS versus GP in Asian patients with EGFR mutation-positive NSCLC (NCT01342965). © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex III.

    PubMed

    Korge, Paavo; Calmettes, Guillaume; John, Scott A; Weiss, James N

    2017-06-16

    Recent evidence has implicated succinate-driven reverse electron transport (RET) through complex I as a major source of damaging reactive oxygen species (ROS) underlying reperfusion injury after prolonged cardiac ischemia. However, this explanation may be incomplete, because RET on reperfusion is self-limiting and therefore transient. RET can only generate ROS when mitochondria are well polarized, and it ceases when permeability transition pores (PTP) open during reperfusion. Because prolonged ischemia/reperfusion also damages electron transport complexes, we investigated whether such damage could lead to ROS production after PTP opening has occurred. Using isolated cardiac mitochondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III generates significant amounts of ROS in the presence of Mg(2+) and NAD(+) and the absence of exogenous substrates upon inner membrane pore formation by alamethicin or Ca(2+)-induced PTP opening. We show that H2O2 production under these conditions is related to Mg(2+)-dependent NADH generation by malic enzyme. H2O2 production is blocked by stigmatellin, indicating its origin from complex III, and by piericidin, demonstrating the importance of NADH-related ubiquinone reduction for ROS production under these conditions. For maximal ROS production, the rate of NADH generation has to be equal or below that of NADH oxidation, as further increases in [NADH] elevate ubiquinol-related complex III reduction beyond the optimal range for ROS generation. These results suggest that if complex III is damaged during ischemia, PTP opening may result in succinate/malate-fueled ROS production from complex III due to activation of malic enzyme by increases in matrix [Mg(2+)], [NAD(+)], and [ADP]. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. Trapping Open and Closed Forms of FitE-A Group III Periplasmic Binding Protein

    SciTech Connect

    Shi, R.; Proteau, A; Wagner, J; Cui, Q; Purisima, E; Matte, A; Cygler, M

    2009-01-01

    Periplasmic binding proteins (PBPs) are essential components of bacterial transport systems, necessary for bacterial growth and survival. The two-domain structures of PBPs are topologically classified into three groups based on the number of crossovers or hinges between the globular domains: group I PBPs have three connections, group II have two, and group III have only one. Although a large number of structures for group I or II PBPs are known, fewer group III PBPs have been structurally characterized. Group I and II PBPs exhibit significant domain motions during transition from the unbound to ligand-bound form, however, no large conformational changes have been observed to date in group III PBPs. We have solved the crystal structure of a periplasmic binding protein FitE, part of an iron transport system, fit, recently identified in a clinical E. coli isolate. The structure, determined at 1.8 {angstrom} resolution, shows that FitE is a group III PBP containing a single {alpha}-helix bridging the two domains. Among the individual FitE molecules present in two crystal forms we observed three different conformations (open, closed, intermediate). Our crystallographic and molecular dynamics results strongly support the notion that group III PBPs also adopt the same Venus flytrap mechanism as do groups I and II PBPs. Unlike other group III PBPs, FitE forms dimers both in solution and in the crystals. The putative siderophore binding pocket is lined with arginine residues, suggesting an anionic nature of the iron-containing siderophore.

  15. Infection Reduces Return-to-duty Rates for Soldiers with Type III Open Tibia Fractures

    DTIC Science & Technology

    2014-09-01

    Type III open tibia fracture and tabulated the prevalence of infectious complications.We searched the Physical Evaluation Board database to determine...disability among combat casualties, with an average disability rating of 42% based on the Physical Evaluation Board.8 In addition, it has been...redness, warmth , swelling, or purulence that required operative inter- vention. Osteomyelitis was defined as deep infection with positive bone cultures

  16. Infection reduces return-to-duty rates for soldiers with Type III open tibia fractures.

    PubMed

    Napierala, Matthew A; Rivera, Jessica C; Burns, Travis C; Murray, Clinton K; Wenke, Joseph C; Hsu, Joseph R

    2014-09-01

    Infection is a potentially devastating complication following severe lower extremity trauma, but its impact on the outcomes of combat casualties remains unclear. We hypothesize that orthopedic infectious complications will have a negative impact on holistic patient outcome as measured by return-to-duty (RTD) and disability ratings among wounded soldiers. We reviewed the medical records for 115 wounded soldiers who sustained a Type III open tibia fracture and tabulated the prevalence of infectious complications. We searched the Physical Evaluation Board database to determine the disability ratings of soldiers with and without an infection and how many of each group was able to return to active duty service. The average percent disability rating and RTD rates between groups were compared using an unpaired t test and χ test, respectively. Overall, 40% of our cohort had an infectious complication of their fractured limb. Twenty-one soldiers were able to RTD, while 94 could not and were medically retired. Of those medically retired, 44% had an infection. The average percent disability among soldiers with infection was 55%, compared with 47% for those who were not infected (p = 0.1407). Soldiers who experienced any type of infectious complication (p = 0.0470) and having osteomyelitis (p = 0.0335) had a lower chance of RTD compared with those who had no infection. Having a deep soft tissue infection alone showed a strong trend toward decreased RTD rate (p = 0.0558). Infectious complications following severe lower extremity trauma significantly decrease the rate of RTD. In addition, the presence of infectious complications demonstrates a trend toward higher disability ratings in the combat wounded. Prognostic study, level III.

  17. NWCC Transmission Case Study III

    SciTech Connect

    Terry Allison, Steve Wiese

    2000-03-01

    OAK-B135 Transmission System Improvements for Wind Energy Development in the Upper Midwest and Great Plains: Opportunities and Obstacles. This case study set out to ascertain the validity of three assumptions from the perspectives of stakeholders involved in wind energy and transmission issues in the Upper Midwest and Great Plains. The assumptions, and the stakeholders' reactions to each, are summarized below: Assumption 1--Transmission system improvements would provide significant benefits to the electricity network and its customers. Respondents acknowledge the potential for overall system benefits in the form of reduced line losses, improved grid stability and reliability, and enhanced ability to conduct spot market transactions. They also agree that these benefits relate to specific regional needs. However, there is disagreement over the extent of other benefits such as efficiency gains and cost savings from reduced line losses. Further, environmental and community interest groups point out that none of these benefits are realized without significant financial, environmental and social costs. Assumption 2--The benefits of transmission improvements would be helpful, but not confined, to wind power. All respondents agree that wind energy could benefit from transmission system improvements. But they also acknowledge, reluctantly, in the case of environmental stakeholders, that the benefits of an improved transmission system cannot be limited to environmentally preferable forms of generation. Some environmental and community advocate respondents also feel that transmission system improvement projects can be avoided altogether through energy conservation and efficiency measures, and by substituting wind energy for fossil generation. Assumption 3--Transmission alliances among stakeholders within and external to the wind community can provide benefits in the public interest. The fractured, multi-jurisdictional governance of the regional transmission system, and the

  18. Alberta Grade III Achievement Study. Fall 1978.

    ERIC Educational Resources Information Center

    Clarke, S. C. T.; And Others

    As a companion project to the Edmonton Grade III Achievement: 1956-1977 Comparisons, this study had two purposes: to establish benchmarks of basic skills achievement and to compare the achievement of various subgroups. Third grade students in Alberta were administered the Gates MacGinitie Reading Tests--Vocabulary and Comprehension, and the…

  19. Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial)

    PubMed Central

    Aoyagi, Reiko; Hamada, Hiromichi; Sato, Yasunori; Suzuki, Hiroyuki; Onouchi, Yoshihiro; Ebata, Ryota; Terauchi, Moe; Terai, Masaru; Hanaoka, Hideki; Hata, Akira

    2015-01-01

    Introduction Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown aetiology that predominantly affects infants and young children. We hypothesise that cyclosporin A (CsA) may be effective in treating KD by regulating the Ca2+/NFAT signalling pathway. This trial compares the current standard therapy of intravenous immunoglobulin (IVIG) and the combined IVIG+CsA therapy in paediatric patients with severe KD. Methods and analysis This trial is a phase III, multicentre, randomised, open-label, blinded-end point trial that evaluates the efficacy and safety of IVIG+CsA therapy. Patients with severe KD who satisfy the eligibility criteria are randomised (1:1) to receive either CsA (5 mg/kg/day for 5 days; Neoral) plus high-dose IVIG (2 g/kg for 24 h and aspirin 30 mg/kg/day), or high-dose IVIG alone (2 g/kg for 24 h and aspirin 30 mg/kg/day). The primary end point is the frequency of occurrence of coronary artery abnormalities during the trial period. An independent end point review committee will be in charge of the trial assessment. Ethics and dissemination The protocol was approved by the Institutional Review Board of each institution. The trial was notified and registered at the Pharmaceutical and Medical Devices Agency, in Japan. The trial is currently on-going and is scheduled to finish in April 2017. The findings will be disseminated through peer-reviewed publications and conference presentations. Trial registration number JMA-IIA00174; Pre-results. PMID:26628527

  20. Management of an Adult with Spaced Dentition, Class III Malocclusion and Open-bite Tendency

    PubMed Central

    Kaya, Demet; Taner, Tulin Ugur

    2011-01-01

    The aim of this case report was to present the orthodontic treatment of an adult with spaced dentition, Class III malocclusion, and open-bite tendency. A 28.4-year-old adult woman was concerned about the unesthetic appearance of her spaced dentition localized at both upper and lower arches while smiling. She had a mild tongue thrust, hypertropic upper frenum, and mild speech difficulty while pronouncing “s”. Her profile was straight with prominent lips. Molar relationship was Class III on both sides. Anterior teeth were in an end-to-end relationship. Lower dental midline was deviated to the left side. Cephalometric analysis revealed a skeletal Class III relationship with hyperdivergent facial pattern. The treatment plan included myotherapeutic exercises for the tongue thrust habit and a diagnostic set-up for closure of diastemas. A strict retention protocol was followed combined with gingivoplasty, fiberotomy, and frenectomy procedures. All spaces were closed successfully, adequate overbite and overjet relationships were obtained, and tongue thrust habit and speech difficulty while pronouncing “s” were eliminated. Clinical and cephalometric results indicated the maintenance of the treatment outcome at 6-months post-retention period. PMID:21228963

  1. Application of Protocols Devised to Study Bi(III) Complex Formation by Voltammetry: The Bi(III)-Picolinic Acid System.

    PubMed

    Billing, Caren; Cukrowski, Ignacy

    2016-12-22

    Bi(III) coordination chemistry has been largely neglected due to the difficulties faced when studying these systems even though Bi(III) is used in various medicinal applications. This study of the Bi(III)-picolinic acid system by voltammetry applies the rigorous methodologies already developed to enable the study of Bi(III) systems starting in very acidic solutions to prevent precipitation. This includes calibrating the glass electrode accurately at these low pHs, compensating for the diffusion junction potential below pH 2 and determining the reduction potential of uncomplexed Bi(III) which cannot be directly measured. The importance of including nitrate from the background electrolyte as a competing species is highlighted, especially for data acquired below pH ∼ 2. From analysis of the voltammetric data, it was not clear whether a ML3OH species formed in solution or whether it was a combination of ML4 and ML4OH. Information from crystal structures and electrospray ionization-mass spectrometry measurements was thus used to propose the most probable species model. The log β values determined were 7.77 ± 0.07 for ML, 13.89 ± 0.07 for ML2, 18.61 ± 0.01 for ML3, 22.7 ± 0.2 for ML4, and 31.4 ± 0.2 for ML4OH. Application of these methodologies thus opens the door to broaden our understanding of Bi(III) complexation.

  2. Adjunctive intraocular and peri-ocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing vitreoretinal surgery for open globe trauma (ASCOT): study protocol for a phase III, multi-centre, double-masked randomised controlled trial.

    PubMed

    Banerjee, Philip J; Cornelius, Victoria R; Phillips, Rachel; Lo, Jessica W; Bunce, Catey; Kelly, Joanna; Murphy, Caroline; Edwards, Rhiannon Tudor; Robertson, Elizabeth L; Charteris, David G

    2016-07-22

    Eyes sustaining open globe trauma are at high risk of severe visual impairment. Ocular injuries which result in visual loss invariably affect the posterior segment of the eye, and prevention of visual loss involves posterior segment (vitreoretinal) surgery. Despite improvements in vitreoretinal surgical techniques, outcomes in these patients remain unsatisfactory, and development of the intraocular scarring response proliferative vitreoretinopathy is the leading cause. Proliferative vitreoretinopathy is the most common cause of recurrent retinal detachment in these eyes; it is reported to occur in up to 45 % of cases. The Adjunctive Steroid Combination in Ocular Trauma (ASCOT) trial is a multi-centre, double-masked, parallel-arm randomised controlled trial with an internal pilot designed to investigate the effectiveness and cost-effectiveness of using intravitreal and sub-Tenon's triamcinolone acetonide peri-operatively in patients undergoing vitrectomy following open globe trauma. In total, 300 eyes of 300 patients will be recruited and randomly allocated to one of two treatment groups. Both groups will receive standard surgical treatment and routine pre-operative and post-operative treatment and care. The treatment group will receive an adjunctive peri-operative steroid combination (triamcinolone acetonide) consisting of 4 mg/0.1 ml into the vitreous cavity and 40 mg/1 ml into the sub-Tenon's space. The trial incorporates a two-stage internal pilot to examine projected recruitment and retention rates. Progression criteria from the internal pilot study will enable us to determine whether to undertake the main trial. Patients and primary outcome assessors will be masked to treatment allocation. The primary outcome will be an improvement from baseline to 6 months of at least 10 on the corrected visual acuity as measured by ETDRS letter score. Secondary outcomes will be development of scarring, retinal detachment, intraocular pressure abnormalities, quality of

  3. A phase III single arm, multicenter, open-label study to assess the immunogenicity and tolerability of a pentavalent DTwP–HepB–Hib vaccine in indian infants

    PubMed Central

    Eregowda, Adarsh; Lalwani, Sanjay; Chatterjee, Sukanta; Vakil, Hoshang; Ahmed, Khaleel; Costantini, Marco; Lattanzi, Maria

    2013-01-01

    Compliance with recommended vaccinations for Indian infants is facilitated by using combination vaccines to minimize the number of required injections. The ready-to-use, preservative free, fully-liquid combination DTwP–HepB–Hib vaccine, Quinvaxem®, offers convenience of administering five important vaccine antigens to infants in a single injection. This phase III, single-arm, multicenter study was designed to assess immunogenicity and safety of three doses of Quinvaxem® to Indian infants administered at 6, 10, and 14 weeks of age. Blood samples were taken prior to the first dose and at one month post last vaccination. Infants were observed clinically for any reaction approximately 30 min following each vaccination, and parents completed subject diaries for solicited local, systemic and any adverse events (AEs) following over a 5 d period. DTwP–HepB–Hib vaccine elicited strong immune responses that exceeded seroprotection/seroconversion thresholds against all vaccine antigens. At one month after third vaccination, percentages of infants achieving predefined protective antibody levels were 99% diphtheria; 100% tetanus; 98% Hepatitis B; 100% Hib short-term (≥ 0.15 µg/mL); 95% Hib long-term (≥ 1.0 µg/mL) protection; and relevant immune response was 99% for pertussis. The vaccine was well tolerated, with no vaccine-related serious AEs. Only one case of high fever (≥ 40°C) was reported. The most frequently reported reactions were mild to moderate tenderness and erythema. Frequencies of all AEs declined with subsequent vaccinations. This study demonstrated that this convenient, fully-liquid DTwP–HepB–Hib vaccine is highly immunogenic and has a acceptable safety profile for use in Indian infants. ClinicalTrials.gov Identifier: NCT01470287. Clinical Trials Registry of India Number: CTRI/2011/11/002118 PMID:23783081

  4. Presurgical orthodontics versus no presurgical orthodontics: treatment outcome of surgical-orthodontic correction for skeletal class III open bite.

    PubMed

    Liao, Yu-Fang; Chiu, Yu-Ting; Huang, Chiung-Shing; Ko, Ellen Wen-Ching; Chen, Yu-Ray

    2010-12-01

    It has long been claimed that presurgical orthodontics is crucial to the outcome of surgical-orthodontic treatment for dentofacial deformity. However, in the literature, the effect of presurgical orthodontics on the treatment outcome remains controversial. The purpose of the study was therefore to investigate the effect of presurgical orthodontics on the treatment outcome in terms of facial aesthetics, occlusion, stability, and efficiency. Thirty-three adult patients with skeletal class III open bite corrected by Le Fort I posterior impaction and bilateral sagittal split osteotomy were included. The patients were divided into two groups: 13 received presurgical orthodontics, and 20 did not. Cephalometric radiographs and study models were used to evaluate the treatment outcome. There were no between-group differences in facial aesthetics, overbite, or Peer Assessment Rating score. Overjet was larger in the no-presurgical orthodontics group than in the presurgical orthodontics group, but both were within normal limits. Both groups had similar maxillary and horizontal mandibular stability. Although the vertical mandibular stability was worse in the no-presurgical orthodontics group than in the presurgical orthodontics group, the direction of instability was favorable for open bite correction. Finally, longer treatment time was required in the presurgical orthodontics group compared with the no-presurgical orthodontics group (512±103 days versus 342±127 days; p<0.001). The results suggest that in surgical-orthodontic correction of skeletal class III open bite, presurgical orthodontics has no clinically significant effects on facial aesthetics, occlusion, or stability. However, presurgical orthodontics has a significant adverse effect on efficiency. Patients receiving presurgical orthodontics undergo longer treatment time than those receiving no presurgical orthodontics.

  5. Open-label, randomized, multicenter, phase III study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: A secondary publication.

    PubMed

    Kawashima, Makoto; Nagare, Toshitaka; Katsuramaki, Tsuneo

    2017-02-02

    An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. In total, 458 subjects were included in the efficacy and safety analyses. The total lesion count, the efficacy end-point, was similarly changed both in the 2.5% and 5% BPO groups over the course of the study. The median rates of reduction from baseline to week 12 were approximately 65%. Thereafter, the counts were maintained at a reduced level without increasing until week 52. The median rates at week 52 were approximately 80%. Similar trends were observed for inflammatory and non-inflammatory lesion counts. Bacteriological evaluation indicated similar distribution of the minimum inhibitory concentration of each of the antibacterial drugs against Propionibacterium acnes between the values at baseline and at week 52, suggesting that long-term use did not result in changes in the drug sensitivity. The incidence of adverse events was 84.0% in the 2.5% BPO group and 87.2% in the 5% BPO group. Many of the adverse events occurred within the first month and were mild or moderate in severity and transient. The results suggest that both 2.5% and 5% BPO gels are effective and safe for long-term treatment of patients with acne vulgaris.

  6. The little-studied cluster Berkeley 90 - III. Cluster parameters

    NASA Astrophysics Data System (ADS)

    Marco, Amparo; Negueruela, Ignacio

    2017-02-01

    The open cluster Berkeley 90 is the home to one of the most massive binary systems in the Galaxy, LS III +46°11, formed by two identical, very massive stars (O3.5 If* + O3.5 If*), and a second early-O system (LS III +46°12 with an O4.5 IV((f)) component at least). Stars with spectral types earlier than O4 are very scarce in the Milky Way, with no more than 20 examples. The formation of such massive stars is still an open question today, and thus the study of the environments where the most massive stars are found can shed some light on this topic. To this aim, we determine the properties and characterize the population of Berkeley 90 using optical, near-infrared and WISE photometry and optical spectroscopy. This is the first determination of these parameters with accuracy. We find a distance of 3.5^{+0.5}_{-0.5} kpc and a maximum age of 3 Ma. The cluster mass is around 1000 M⊙ (perhaps reaching 1500 M⊙ if the surrounding population is added), and we do not detect candidate runaway stars in the area. There is a second population of young stars to the southeast of the cluster that may have formed at the same time or slightly later, with some evidence for low-activity ongoing star formation.

  7. Pre-operative variables affecting final vision outcome with a critical review of ocular trauma classification for posterior open globe (zone III) injury.

    PubMed

    Agrawal, Rupesh; Ho, Sue Wei; Teoh, Stephen

    2013-10-01

    To identify pre-operative variables affecting the outcome of posterior open globe (zone III) injuries. Secondary objective was to re-look at the definition or landmarks for zone III injury and its clinical significance for predicting visual prognosis following open globe injury. Retrospective review of medical records of all hospitalized patients with surgical repair of open globe injury over last 10 years at a tertiary referral eye care center in Singapore. Out of 172 eyes with open globe injury, 28 eyes (16.3%) with zone III injury was identified and reviewed further. Pre-operative visual acuity (VA) and other variables, extent of scleral wound in reference to rectus insertion, relative afferent pupillary defect (RAPD) and final vision outcome were recorded. Median age was 37 years with male predilection (92.9%). Mean follow-up was 12.9 months. Pre-operative VA was no light perception (NLP) in 16 (57.1%) eyes. Final VA remained NLP in 14 eyes (50.0%). The factors contributing to poor post-operative vision based on univariate regression analysis were the presence of RAPD, poor pre-operative VA, blunt trauma, extent of trauma, associated traumatic cataract, hyphema, vitreous loss and associated vitreo-retinal trauma. Further on, zone III injuries with scleral wound limited anterior to rectus insertion (6 eyes) had better vision outcome than those with injuries extending beyond rectus insertion (22 eyes). Initial VA, blunt ocular trauma, visual axis involvement, loss of light perception, presence of RAPD, traumatic cataract, hyphema, vitreous loss were the important determinants for final visual outcome in patients with zone III injury. Wound extending posterior to rectus insertion has poorer outcome as those limited anterior to rectus insertion. We suggest that there may be a need to relook at zone III injuries with reference to rectus insertion for prognostic significance, and further studies are warranted.

  8. Pre-operative variables affecting final vision outcome with a critical review of ocular trauma classification for posterior open globe (zone III) injury

    PubMed Central

    Agrawal, Rupesh; Ho, Sue Wei; Teoh, Stephen

    2013-01-01

    Purpose: To identify pre-operative variables affecting the outcome of posterior open globe (zone III) injuries. Secondary objective was to re-look at the definition or landmarks for zone III injury and its clinical significance for predicting visual prognosis following open globe injury. Materials and Methods: Retrospective review of medical records of all hospitalized patients with surgical repair of open globe injury over last 10 years at a tertiary referral eye care center in Singapore. Out of 172 eyes with open globe injury, 28 eyes (16.3%) with zone III injury was identified and reviewed further. Pre-operative visual acuity (VA) and other variables, extent of scleral wound in reference to rectus insertion, relative afferent pupillary defect (RAPD) and final vision outcome were recorded. Results: Median age was 37 years with male predilection (92.9%). Mean follow-up was 12.9 months. Pre-operative VA was no light perception (NLP) in 16 (57.1%) eyes. Final VA remained NLP in 14 eyes (50.0%). The factors contributing to poor post-operative vision based on univariate regression analysis were the presence of RAPD, poor pre-operative VA, blunt trauma, extent of trauma, associated traumatic cataract, hyphema, vitreous loss and associated vitreo-retinal trauma. Further on, zone III injuries with scleral wound limited anterior to rectus insertion (6 eyes) had better vision outcome than those with injuries extending beyond rectus insertion (22 eyes). Conclusion: Initial VA, blunt ocular trauma, visual axis involvement, loss of light perception, presence of RAPD, traumatic cataract, hyphema, vitreous loss were the important determinants for final visual outcome in patients with zone III injury. Wound extending posterior to rectus insertion has poorer outcome as those limited anterior to rectus insertion. We suggest that there may be a need to relook at zone III injuries with reference to rectus insertion for prognostic significance, and further studies are warranted. PMID

  9. Formylated chloro-bridged iridium(III) dimers as OLED materials: opening up new possibilities.

    PubMed

    Wong, Michael Y; Xie, Guohua; Tourbillon, Clarisse; Sandroni, Martina; Cordes, David B; Slawin, Alexandra M Z; Samuel, Ifor D W; Zysman-Colman, Eli

    2015-05-14

    In this study, a series of four formyl-substituted chloro-bridged iridium(iii) dimers were prepared. Their absorption, photophysical and electrochemical properties were studied in dichloromethane solution. It was found that as the formyl content increased on the cyclometalating ligands, emission unexpectedly became brighter. Organic light-emitting diodes (OLEDs) were fabricated using each of these iridium dimers as the emitter. The OLED fabricated using the brightest of the series, 2b, as the dopant afforded a decent external quantum efficiency (EQE) of 2.6%. This suggests that chloro-bridged iridium dimers are potential candidates as solid-state emitters.

  10. Experimental and Theoretical Studies on Biologically Active Lanthanide (III) Complexes

    NASA Astrophysics Data System (ADS)

    Kostova, I.; Trendafilova, N.; Georgieva, I.; Rastogi, V. K.; Kiefer, W.

    2008-11-01

    The complexation ability and the binding mode of the ligand coumarin-3-carboxylic acid (HCCA) to La(III), Ce(III), Nd(III), Sm(III), Gd(III) and Dy(III) lanthanide ions (Ln(III)) are elucidated at experimental and theoretical level. The complexes were characterized using elemental analysis, DTA and TGA data as well as 1H NMR and 13C NMR spectra. FTIR and Raman spectroscopic techniques as well as DFT quantum chemical calculations were used for characterization of the binding mode and the structures of lanthanide(III) complexes of HCCA. The metal—ligand binding mode is predicted through molecular modeling and energy estimation of different Ln—CCA structures using B3LYP/6-31G(d) method combined with a large quasi-relativistic effective core potential for lanthanide ion. The energies obtained predict bidentate coordination of CCA- to Ln(III) ions through the carbonylic oxygen and the carboxylic oxygen. Detailed vibrational analysis of HCCA, CCA- and Ln(III) complexes based on both calculated and experimental frequencies confirms the suggested metal—ligand binding mode. The natural bonding analysis predicts strongly ionic character of the Ln(III)-CCA bonding in the- complexes studied. With the relatively resistant tumor cell line K-562 we obtained very interesting in-vitro results which are in accordance with our previously published data concerning the activity of lanthanide(III) complexes with other coumarin derivatives.

  11. Inside Open Learning. Studies in Further Education.

    ERIC Educational Resources Information Center

    Bagley, Bill; Challis, Bob

    A study examined the experience of teachers, students, and college administrators in the following three open learning schemes for adult students in Great Britain: Flexistudy at Abraham Moss Open College, the mathematics and communications workshops at Bradford College, and the Technical Education Council programs at Moston College of Further…

  12. Nonsurgical and nonextraction treatment of skeletal Class III open bite: its long-term stability.

    PubMed

    Kondo, E; Aoba, T J

    2000-03-01

    Two female patients, aged 14 years 5 months and 17 years 3 months with skeletal Class III open bite and temporomandibular dysfunction are presented. They had previously been classified as orthognathic surgical cases, involving first premolar removal. The primary treatment objective was to eliminate those skeletal and neuromuscular factors that were dominant in establishing their malocclusions. These included abnormal behavior of the tongue with short labial and lingual frenula, bilateral imbalance of chewing muscles, a partially blocked nasopharyngeal airway causing extrusion of the molars, with rotation of the mandible and narrowing of the maxillary arch. Resultant occlusal interference caused the mandible to shift to one side, which in turn produced the abnormal occlusal plane and curve of Spee. As a result, the form and function of the joints were adversely affected by the structural and functional asymmetry. These cases were treated by expanding the maxillary arch, which brought the maxilla downward and forward. The mandible moved downward and backward, with a slight increase in anterior facial height. Intruding and uprighting the posterior teeth, combined with a maxillary protraction, reconstructed the occlusal plane. A favorable perioral environment was created with widened tongue space in order to produce an adequate airway. Myofunctional therapy after lingual and labial frenectomy was assisted by vigorous gum chewing during and after treatment, together with a tooth positioner. Normal nasal breathing was achieved.

  13. Observing Protein & Energy Nutrition (OPEN) Study

    Cancer.gov

    The Observing Protein and Energy Nutrition (OPEN) Study was designed to assess dietary measurement error by comparing results from self-reported dietary intake data with four dietary biomarkers: doubly labeled water and urinary nitrogen, sodium, and potassium.

  14. [Principle and practice of clinical phase III studies].

    PubMed

    Morant, Rudolf

    2008-01-01

    Randomized phase III studies compare new treatments with standard therapy according to defined guidelines and legal rules. Large international randomized phase III studies are some of the most complex and expensive medical experiments. The results of such trials will decide about the future of new drugs and are the basis of evidence-based medicine and the development of clinical guidelines. This contribution discusses randomization, endpoints, inclusion and exclusion criteria of phase III trials as well as further challenges when developing and conducting phase III studies in oncology. Copyright 2008 S. Karger AG, Basel.

  15. Catalytic consequences of open and closed grafted Al(III)-calix[4]arene complexes for hydride and oxo transfer reactions

    PubMed Central

    Nandi, Partha; Tang, Wenjie; Okrut, Alexander; Kong, Xueqian; Hwang, Son-Jong; Neurock, Matthew; Katz, Alexander

    2013-01-01

    An approach for the control and understanding of supported molecular catalysts is demonstrated with the design and synthesis of open and closed variants of a grafted Lewis acid active site, consisting of Al(III)-calix[4]arene complexes on the surface of silica. The calixarene acts as a molecular template that enforces open and closed resting-state coordination geometries surrounding the metal active sites, due to its lower-rim substituents as well as site isolation by virtue of its steric bulk. These sites are characterized and used to elucidate mechanistic details and connectivity requirements for reactions involving hydride and oxo transfer. The consequence of controlling open versus closed configurations of the grafted Lewis acid site is demonstrated by the complete lack of observed activity of the closed site for Meerwein-Ponndorf-Verley (MPV) reduction; whereas, the open variant of this catalyst has an MPV reduction activity that is virtually identical to previously reported soluble molecular Al(III)-calix[4]arene catalysts. In contrast, for olefin epoxidation using tert-butyl-hydroperoxide as oxidant, the open and closed catalysts exhibit similar activity. This observation suggests that for olefin epoxidation catalysis using Lewis acids as catalyst and organic hydroperoxide as oxidant, covalent binding of the hydroperoxide is not required, and instead dative coordination to the Lewis acid center is sufficient for catalytic oxo transfer. This latter result is supported by density functional theory calculations of the transition state for olefin epoxidation catalysis, using molecular analogs of the open and closed catalysts. PMID:23359705

  16. Amine templated open-framework vanadium(III) phosphites with catalytic properties.

    PubMed

    Orive, Joseba; Larrea, Edurne S; Fernández de Luis, Roberto; Iglesias, Marta; Mesa, José L; Rojo, Teófilo; Arriortua, María I

    2013-04-07

    Four novel amine templated open-framework vanadium(III) phosphites with the formula (C(5)N(2)H(14))(0.5)[V(H(2)O)(HPO(3))(2)], 1 (C(5)N(2)H(14) = 2-methylpiperazinium), and (L)(4-x)(H(3)O)(x)[V(9)(H(2)O)(6)(HPO(3))(14-y)(HPO(4))(y)(H(2)PO(3))(3-z)(H(2)PO(4))z]·nH(2)O (2, L = cyclopentylammonium, x = 0, y = 3.5, z = 3, n = 0; , L = cyclohexylammonium, x = 1, y = 0, z = 0.6, n = 2.33; , L = cycloheptylammonium, x = 1, y = 0, z = 0, n = 2.33) were synthesized employing solvothermal reactions and characterized by single-crystal X-ray diffraction, ICP-AES and elemental analyses, thermogravimetric and thermodiffractometric analyses, and IR and UV/vis spectroscopy. Single-crystal data indicate that 1 crystallizes in the triclinic system, space group P1, whereas 2, 3 and 4 crystallize in the hexagonal space group P6(3)/m. Compound 1 has a two-dimensional motif with anionic sheets of [V(H(2)O)(HPO(3))(2)](-) formula, whose charge is compensated by the 2-methylpiperazinium cations embedded between the layers. In contrast, 2, 3 and 4 present a pillar-layer network giving rise to a three-dimensional framework containing intersecting 16-ring channels with the primary amine templates and the crystallization water molecules enclosed in them. 1, 2, 3 and 4 behave as heterogeneous catalysts for the selective oxidation of alkyl aryl sulfides, with tert-butylhydroperoxide (TBHP) as the oxidizing agent, being active, selective and recyclable for several successive cycles of reaction.

  17. Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation.

    PubMed

    Liu, Bin; Zhu, Xuehai; Chen, Chwen-Lih; Hu, Keli; Swartz, Harold M; Chen, Yeong-Renn; He, Guanglong

    2010-04-01

    Diazoxide, a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel opener, protects the heart from ischemia-reperfusion injury. Diazoxide also inhibits mitochondrial complex II-dependent respiration in addition to its preconditioning effect. However, there are no prior studies of the role of diazoxide on post-ischemic myocardial oxygenation. In the current study, we determined the effect of diazoxide on the suppression of post-ischemic myocardial tissue hyperoxygenation in vivo, superoxide (O(2)(-*)) generation in isolated mitochondria, and impairment of the interaction between complex II and complex III in purified mitochondrial proteins. It was observed that diazoxide totally suppressed the post-ischemic myocardial hyperoxygenation. With succinate but not glutamate/malate as the substrate, diazoxide significantly increased ubisemiquinone-dependent O(2)(-*) generation, which was not blocked by 5-HD and glibenclamide. Using a model system, the super complex of succinate-cytochrome c reductase (SCR) hosting complex II and complex III, we also observed that diazoxide impaired complex II and its interaction with complex III with no effect on complex III. UV-visible spectral analysis revealed that diazoxide decreased succinate-mediated ferricytochrome b reduction in SCR. In conclusion, our results demonstrated that diazoxide suppressed the in vivo post-ischemic myocardial hyperoxygenation through opening the mitoK(ATP) channel and ubisemiquinone-dependent O(2)(-*) generation via inhibiting mitochondrial complex II-dependent respiration.

  18. Opening the Ralstonia solanacearum type III effector tool box: insights into host cell subversion mechanisms.

    PubMed

    Deslandes, Laurent; Genin, Stephane

    2014-08-01

    Effectors delivered to host cells by the Type III secretion system are essential to Ralstonia solanacearum pathogenicity, as in several other plant pathogenic bacteria. The establishment of exhaustive effector repertoires in multiple R. solanacearum strains drew a first picture of the evolutionary dynamics of the pathogen effector suites. Effector repertoires are diversified, with a core of 20-30 effectors present in most of the strains and the obtention of mutants lacking one or more effector genes revealed the functional overlap among this effector network. Recent functional studies have provided insights into the ability of single effectors to manipulate the host proteasome, elicit cell death, trigger the expression of plant genes, and/or display biochemical activities on plant protein targets. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Safety and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTPa-IPV/Hib) vaccine in healthy Vietnamese toddlers: An open-label, phase III study

    PubMed Central

    Anh, Dang Duc; Van Der Meeren, Olivier; Karkada, Naveen; Assudani, Deepak; Yu, Ta-Wen; Han, Htay Htay

    2016-01-01

    abstract The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated polio (DTPa-IPV)/Hib vaccine when administered as a booster dose in 300 healthy Vietnamese children <2 years of age (mean age: 15.8 months). During the 4-day follow-up period, pain (31.7%) and redness (27.3%) were the most frequent solicited local symptoms. Pain (2%) was also the most frequent grade 3 local symptom. One subject reported 2 serious adverse events that were not causally related to the study vaccine. DTPa-IPV/Hib conjugate vaccine was well tolerated as a booster dose in healthy Vietnamese children aged <2 years. PMID:26337197

  20. Safety and reactogenicity of the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTPa-IPV/Hib) vaccine in healthy Vietnamese toddlers: An open-label, phase III study.

    PubMed

    Anh, Dang Duc; Van Der Meeren, Olivier; Karkada, Naveen; Assudani, Deepak; Yu, Ta-Wen; Han, Htay Htay

    2016-03-03

    The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated polio (DTPa-IPV)/Hib vaccine when administered as a booster dose in 300 healthy Vietnamese children <2 years of age (mean age: 15.8 months). During the 4-day follow-up period, pain (31.7%) and redness (27.3%) were the most frequent solicited local symptoms. Pain (2%) was also the most frequent grade 3 local symptom. One subject reported 2 serious adverse events that were not causally related to the study vaccine. DTPa-IPV/Hib conjugate vaccine was well tolerated as a booster dose in healthy Vietnamese children aged <2 years.

  1. A multicentre, open-label, randomised phase III study comparing a new levonorgestrel intrauterine contraceptive system (LNG-IUS 8) with combined oral contraception in young women of reproductive age.

    PubMed

    Borgatta, Lynn; Buhling, Kai J; Rybowski, Sarah; Roth, Katrin; Rosen, Kimberly

    2016-10-01

    To compare user satisfaction and adverse events (AEs) with a levonorgestrel intrauterine system (LNG-IUS 8; average levonorgestrel release rate approximately 8 μg/24 h over the first year [total content 13.5 mg]) and a 30 μg ethinyl estradiol/3 mg drospirenone (EE/DRSP) combined oral contraceptive (COC) in a population of young women. Nulliparous and parous women (aged 18-29 years) with regular menstrual cycles (21-35 days) were randomised to LNG-IUS 8 or EE/DRSP for 18 months. The primary endpoint was the overall user satisfaction rate at month 18/end of study visit. Overall, 279 women were randomised to LNG-IUS 8 with attempted placement and 281 women were randomised to EE/DRSP and took ≥1 pill; the mean age was 23.7 and 23.9 years, and 77.4% and 73.3% were nulliparous, respectively. At month 18/end of study, 82.1% and 81.9% of women, respectively, reported being 'very satisfied' or 'satisfied' with their treatment; however, significantly more LNG-IUS 8 users reported a preference to continue their treatment post-study (66.2% vs 48.8%; p = 0.0001). There were two pregnancies (one ectopic pregnancy, one spontaneous abortion) reported in the LNG-IUS 8 group and six (three live births, two spontaneous abortions, one induced abortion) in the EE/DRSP group. LNG-IUS 8 and EE/DRSP were associated with similarly high user satisfaction rates. However, LNG-IUS 8 users were significantly more likely to prefer to continue their contraceptive method post-study, indicating that a levonorgestrel intrauterine system is an appealing contraceptive option for young women.

  2. Interdisciplinary treatment of a patient with amelogenesis imperfecta, a skeletal Class III relationship, and an anterior open bite.

    PubMed

    Marşan, Gülnaz; Aksu, Irem Sakarya; Kurt, Hanefi; Kuvat, Samet Vasfi; Cura, Nil

    2010-01-01

    An adult woman with amelogenesis imperfecta, a skeletal Class III relationship, long face syndrome, and a severe anterior open bite received interdisciplinary treatment (orthodontics, orthognathic surgery, and prosthodontics). Presurgical orthodontic treatment was followed by a maxillary posterior impaction with anterior advancement and a mandibular setback. After surgery, the patient received ceramic crowns. Function and esthetics were successfully re-established. © 2010 BY QUINTESSENCE PUBLISHING CO, INC.

  3. Efficacy and safety profile of combination of tramadol-diclofenac versus tramadol-paracetamol in patients with acute musculoskeletal conditions, postoperative pain, and acute flare of osteoarthritis and rheumatoid arthritis: a Phase III, 5-day open-label study

    PubMed Central

    Chandanwale, Ajay S; Sundar, Subramanian; Latchoumibady, Kaliaperumal; Biswas, Swati; Gabhane, Mukesh; Naik, Manoj; Patel, Kamlesh

    2014-01-01

    Objective We aimed to evaluate the safety and efficacy of a fixed-dose combination (FDC) of tramadol and diclofenac versus a standard approved FDC of tramadol and paracetamol, in patients with acute moderate to severe pain. Methods A total of 204 patients with moderate to severe pain due to acute musculoskeletal conditions (n=52), acute flare of osteoarthritis (n=52), acute flare of rheumatoid arthritis (n=50), or postoperative pain (n=50) were enrolled in the study at baseline. Each disease category was then randomized to receive either of two treatments for 5 days: group A received an FDC of immediate-release tramadol hydrochloride (50 mg) and sustained-release diclofenac sodium (75 mg) (one tablet, twice daily), and group B received an FDC of tramadol hydrochloride (37.5 mg) and paracetamol (325 mg) (two tablets every 4–6 hours, up to a maximum of eight tablets daily). The primary efficacy end points were reductions in pain intensity from baseline at day 3 and day 5 as assessed by a Visual Analog Scale (VAS) score. Results Group A showed a significant reduction in the VAS score for overall pain from baseline on day 3 (P=0.001) and day 5 (P<0.0001) as compared with group B. The combination of tramadol-diclofenac resulted in few mild to moderate adverse events (nausea, vomiting, epigastric pain, and gastritis), which required minimal management, without any treatment discontinuation. The number of adverse events in group A was nine (8.82%) compared with 22 (21.78%) in group B, after 5 days of treatment. Conclusion An FDC of tramadol-diclofenac showed a significantly greater reduction in pain intensity and was well tolerated compared with tramadol-paracetamol, resulting in better analgesia in patients suffering from moderate to severe pain due to acute musculoskeletal conditions, postoperative pain following orthopedic surgery, or acute flare of osteoarthritis and rheumatoid arthritis. PMID:25152629

  4. CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

    PubMed

    Pivot, Xavier; Manikhas, Alexey; Żurawski, Bogdan; Chmielowska, Ewa; Karaszewska, Boguslawa; Allerton, Rozenn; Chan, Stephen; Fabi, Alessandra; Bidoli, Paolo; Gori, Stefania; Ciruelos, Eva; Dank, Magdolna; Hornyak, Lajos; Margolin, Sara; Nusch, Arnd; Parikh, Roma; Nagi, Fareha; DeSilvio, Michelle; Santillana, Sergio; Swaby, Ramona F; Semiglazov, Vladimir

    2015-05-10

    CEREBEL compared the incidence of CNS metastases as first site of relapse in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer receiving lapatinib-capecitabine or trastuzumab-capecitabine. Patients without baseline CNS metastases were randomly assigned (1:1) to receive lapatinib-capecitabine (lapatinib 1,250 mg per day; capecitabine 2,000 mg/m(2) per day on days 1 to 14 every 21 days) or trastuzumab-capecitabine (trastuzumab loading dose of 8 mg/kg followed by an infusion of 6 mg/kg every 3 weeks; capecitabine 2,500 mg/m(2) per day on days 1 to 14 every 21 days). The primary end point was incidence of CNS metastases as first site of relapse. Secondary end points included progression-free survival (PFS) and overall survival (OS). The study was terminated early with 540 enrolled patients (271 received lapatinib-capecitabine, and 269 received trastuzumab-capecitabine). Incidence of CNS metastases as first site of relapse was 3% (eight of 251 patients) for lapatinib-capecitabine and 5% (12 of 250 patients) for trastuzumab-capecitabine (treatment differences, -1.6%; 95% CI, -2% to 5%; P = .360). PFS and OS were longer with trastuzumab-capecitabine versus lapatinib-capecitabine (hazard ratio [HR] for PFS, 1.30; 95% CI, 1.04 to 1.64; HR for OS, 1.34; 95% CI, 0.95 to 1.64). Serious adverse events were reported in 13% (34 of 269 patients) and 17% (45 of 267 patients) of patients in the lapatinib-capecitabine and trastuzumab-capecitabine arms, respectively. CEREBEL is inconclusive for the primary end point, and no difference was detected between lapatinb-capecitabine and trastuzumab-capecitabine for the incidence of CNS metastases. A better outcome was observed with trastuzumab-capecitabine in the overall population. However, lapatinib-capecitabine efficacy may have been affected by previous exposure to a trastuzumab regimen and/or when treatment was given as first- or second-line therapy in the metastatic setting. © 2015 by American

  5. VizieR Online Data Catalog: On the metallicity of open clusters. III. (Netopil+, 2016)

    NASA Astrophysics Data System (ADS)

    Netopil, M.; Paunzen, E.; Heiter, U.; Soubiran, C.

    2016-03-01

    In Paper II (Heiter et al., Paper II 2014A&A...561A..93H) we have evaluated available spectroscopic iron abundance determinations of open cluster stars and presented mean values for 78 open clusters. The results are based on high-resolution data (R>=25000) with high signal-to-noise ratios (S/N>=50). Furthermore, quality criteria were introduced by adopting only [Fe/H] measurements of stars with Teff=4400-6500K and logg>=2.0dex. We have to note that the mean iron abundance for Berkeley 29, listed in Paper II, also incorporates some measurements based upon lower S/N data. In the present paper we therefore list the correct values for the higher and lower quality data. Since publication of Paper II, some new studies were made (Boesgaard et al., 2013ApJ...775...58B; Bocek Topcu et al., 2015, Cat. J/MNRAS/446/3562; Carraro et al., 2014A&A...568A..86C; Donati et al., 2015, Cat. J/MNRAS/446/1411; Magrini et al.. 2014A&A...563A..44M, 2015A&A...580A..85M; Molenda-Zakowicz et al., 2014MNRAS.445.2446M; Monaco et al., 2014A&A...564L...6M; Reddy et al., 2015MNRAS.450.4301R), which we examined the same way as described in Paper II. This adds ten open clusters to our list (Berkeley 81, NGC 1342, NGC 1662, NGC 1912, NGC 2354, NGC 4337, NGC 4815, NGC 6811, Trumpler 5, and Trumpler 20) and supplementary data for NGC 752, NGC 2447, NGC 2632, and NGC 6705. (1 data file).

  6. The VPS-20 subunit of the endosomal sorting complex ESCRT-III exhibits an open conformation in the absence of upstream activation.

    PubMed

    Schuh, Amber L; Hanna, Michael; Quinney, Kyle; Wang, Lei; Sarkeshik, Ali; Yates, John R; Audhya, Anjon

    2015-03-15

    Members of the endosomal sorting complex required for transport (ESCRT) machinery function in membrane remodelling processes during multivesicular endosome (MVE) biogenesis, cytokinesis, retroviral budding and plasma membrane repair. During luminal vesicle formation at endosomes, the ESCRT-II complex and the ESCRT-III subunit vacuolar protein sorting (VPS)-20 play a specific role in regulating assembly of ESCRT-III filaments, which promote vesicle scission. Previous work suggests that Vps20 isoforms, like other ESCRT-III subunits, exhibits an auto-inhibited closed conformation in solution and its activation depends on an association with ESCRT-II specifically at membranes [1]. However, we show in the present study that Caenorhabditis elegans ESCRT-II and VPS-20 interact directly in solution, both in cytosolic cell extracts and in using recombinant proteins in vitro. Moreover, we demonstrate that purified VPS-20 exhibits an open extended conformation, irrespective of ESCRT-II binding, in contrast with the closed auto-inhibited architecture of another ESCRT-III subunit, VPS-24. Our data argue that individual ESCRT-III subunits adopt distinct conformations, which are tailored for their specific functions during ESCRT-mediated membrane reorganization events.

  7. 77 FR 62518 - Proposed Collection; Comment Request: Recipient Epidemiology and Donor Evaluation Study-III (REDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... Epidemiology and Donor Evaluation Study-III (REDS-III) Request for Generic Clearance SUMMARY: In compliance...: Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Type of Information Collection Request... Evaluation ] Study-III (REDS-III) program is to ensure safe and effective blood banking and transfusion...

  8. A comparison of pure mode I and mixed mode I-III cracking of an adhesive containing an open knit cloth carrier

    NASA Technical Reports Server (NTRS)

    Ripling, E. J.; Crosley, P. B.; Johnson, W. S.

    1988-01-01

    Static and fatigue tests were carried out on two commercial modified epoxy film adhesives with a wide open knit polyester carrier in order to compare crack resistance in mode I and mixed mode I-III loading. The carrier cloth is found to have a significant influence on the cracking behavior of the adhesives. The open air net carrier used in this study separates from the adhesive in mode I cracking but shreds during mixed-mode crack extension. This decreases the opening mode toughness but increases the mixed-mode toughness as compared with results obtained earlier using a heavier knit carrier. The results suggest that the type of carrier may have a far larger influence on crack resistance than is generally recognized.

  9. Search for giant planets in M67. III. Excess of hot Jupiters in dense open clusters

    NASA Astrophysics Data System (ADS)

    Brucalassi, A.; Pasquini, L.; Saglia, R.; Ruiz, M. T.; Bonifacio, P.; Leão, I.; Canto Martins, B. L.; de Medeiros, J. R.; Bedin, L. R.; Biazzo, K.; Melo, C.; Lovis, C.; Randich, S.

    2016-07-01

    Since 2008 we used high-precision radial velocity (RV) measurements obtained with different telescopes to detect signatures of massive planets around main-sequence and evolved stars of the open cluster (OC) M67. We aimed to perform a long-term study on giant planet formation in open clusters and determine how this formation depends on stellar mass and chemical composition. A new hot Jupiter (HJ) around the main-sequence star YBP401 is reported in this work. An update of the RV measurements for the two HJ host-stars YBP1194 and YBP1514 is also discussed. Our sample of 66 main-sequence and turnoff stars includes 3 HJs, which indicates a high rate of HJs in this cluster (5.6% for single stars and 4.5%% for the full sample). This rate is much higher than what has been discovered in the field, either with RV surveys or by transits. High metallicity is not a cause for the excess of HJs in M67, nor can the excess be attributed to high stellar masses. When combining this rate with the non-zero eccentricity of the orbits, our results are qualitatively consistent with a HJ formation scenario dominated by strong encounters with other stars or binary companions and subsequent planet-planet scattering, as predicted by N-body simulations. Based on observations collected at the ESO 3.6 m telescope (La Silla), at the 1.93 m telescope of the Observatoire de Haute-Provence (OHP), at the Hobby Eberly Telescope (HET), at the Telescopio Nazionale Galileo (TNG, La Palma) and at the Euler Swiss Telescope.

  10. Reform Week III. Open Systems Concepts & Application to DoD Weapon Systems

    DTIC Science & Technology

    2007-11-02

    exercise reinforces material in Open Systems Approach. It emphasizes the importance of selecting appropriate interface standards and illustrates risk ...Control - Lack of Techn ical Data - Ongoing Stan dards Managem ent - Replacement Spares Risk & Strategic Suppl ier Relationship s - Trading Requ...which our weapon systems operate may make it difficult to use commercial components. The open systems approach is neither a panacea nor risk free. The

  11. PLCO Ovarian Phase III Validation Study — EDRN Public Portal

    Cancer.gov

    Our preliminary data indicate that the performance of CA 125 as a screening test for ovarian cancer can be improved upon by additional biomarkers. With completion of one additional validation step, we will be ready to test the performance of a consensus marker panel in a phase III validation study. Given the original aims of the PLCO trial, we believe that the PLCO represents an ideal longitudinal cohort offering specimens for phase III validation of ovarian cancer biomarkers.

  12. Correction of dental Class III with posterior open bite by simple biomechanics using an anterior C-tube miniplate

    PubMed Central

    Ahn, Hyo-Won; Chung, Kyu-Rhim; Kang, Suk-Man; Lin, Lu; Nelson, Gerald

    2012-01-01

    In the correction of dental Class III molar relationship in skeletal Class II patients, uprighting of the mandibular posterior segments without opening the mandible is an important treatment objective. In the case reported herein, a C-tube miniplate fixed to the lower labial symphysis and connected with a nickel-titanium reverse-curved archwire provided effective uprighting of the lower molars, without the need of orthodontic appliances on the mandibular anteriors. Using this approach, an appropriate magnitude of force is exerted on the molars while avoiding any negative effect on the mandibular anteriors. PMID:23173121

  13. I-COMBINE study: assessment of efficacy and safety profile of irbesartan/amlodipine fixed-dose combination therapy compared with amlodipine monotherapy in hypertensive patients uncontrolled with amlodipine 5 mg monotherapy: a multicenter, phase III, prospective, randomized, open-label with blinded-end point evaluation study.

    PubMed

    Bobrie, Guillaume

    2012-08-01

    Hypertension guidelines recommend the use of 2 agents with synergistic action when >1 agent is needed to achieve blood pressure goals. Newer antihypertensive treatment combinations include fixed-dose combinations of an angiotensin receptor blocker and a calcium channel blocker. The I-COMBINE study aimed to determine whether the antihypertensive efficacy of the fixed-dose combination irbesartan 150 mg/amlodipine 5 mg (I150/A5) was superior to that of amlodipine 5 mg (A5) monotherapy in lowering home systolic blood pressure (HSBP) after 5 weeks' treatment. The I-COMBINE study was a 10-week, multicenter, Phase III, prospective, randomized, parallel-group, open-label with blinded-endpoint study. The main inclusion criterion was essential uncontrolled hypertension (SBP ≥145 mm Hg at office, after at least 4 weeks of A5 monotherapy administered once daily). Patients continued to receive A5 for 7 to 10 days and were randomized to either monotherapy with A5 for 5 weeks then amlodipine 10 mg (A10) for the next 5 weeks or to a fixed-dose combination therapy (I150/A5 then I150/A10). Safety profile was assessed by recording adverse events reported by patients or observed by the investigator. Following enrollment, 290 patients were randomized to treatment, and 287 (mean [SD] age, 57.3 [11.2] years; 48% male) were included in the intention-to-treat analysis: 144 patients treated with I150/A5 then I150/A10, and 143 patients treated with A5 then A10. At randomization, mean HSBP was similar in both groups: 148.5 (10.3) mm Hg in the I150/A5 group and 149.2 (9.7) mm Hg in the A5 group. At week 5, the adjusted mean difference in HSBP between groups was -6.2 (1.0) mm Hg (P < 0.001). The proportion of controlled patients (mean home blood pressure <135 and 85 mm Hg) was significantly higher in the I150/A5 group than in the A5 group (P < 0.001). Treatment-emergent adverse events were experienced by 13.8% of I150/A5-treated patients and 11.9% of A5-treated patients during the first 5

  14. Efficacy and safety of leuprorelin acetate 6-month depot, TAP-144-SR (6M), in combination with tamoxifen in postoperative, premenopausal patients with hormone receptor-positive breast cancer: a phase III, randomized, open-label, parallel-group comparative study.

    PubMed

    Kurebayashi, Junichi; Toyama, Tatsuya; Sumino, Shuuji; Miyajima, Eri; Fujimoto, Tsukasa

    2017-01-01

    Leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, is used worldwide in premenopausal women with hormone receptor-positive breast cancer. This study was conducted to assess the non-inferiority of the 6-month depot formulation, TAP-144-SR (6M) 22.5 mg to the 3-month depot formulation, TAP-144-SR (3M) 11.25 mg in postoperative, premenopausal patients with hormone receptor-positive breast cancer. This was a 96-week phase III, randomized, open-label, parallel-group comparative study. All patients concomitantly received oral tamoxifen (20 mg daily). The primary endpoint was the suppression rate of serum estradiol (E2) to the menopausal level (≤30 pg/mL) from Week 4 through Week 48. In total, 167 patients were randomized to receive TAP-144-SR (6M) (n = 83) or TAP-144-SR (3M) (n = 84) and the E2 suppression rate was 97.6 and 96.4 %, respectively. The estimated between-group difference was 1.2 % (95 % confidence interval -5.2 to 7.8). The non-inferiority of TAP-144-SR (6M) to TAP-144-SR (3M) for E2 suppression was confirmed. As for safety, common adverse events were hot flush and injection site reactions including induration, pain, and erythema in both treatment groups, which were of ≤Grade 2 in severity and not serious. No significant between-group differences in safety profiles and tolerability were observed. TAP-144-SR (6M) was not inferior to TAP-144-SR (3M) for its suppressive effect on serum E2. TAP-144-SR (6M) was also as well tolerated as TAP-144-SR (3M).

  15. Linkage studies in primary open angle glaucoma

    SciTech Connect

    Avramopoulos, D.; Grigoriadu, M.; Kitsos, G.

    1994-09-01

    Glaucoma is a leading cause of blindness worldwide. The majority of glaucoma is associated with an open, normal appearing anterior chamber angle and is termed primary open angle glaucoma (POAG, MIM 137760). It is characterized by elevated intraocular pressure and onset in middle age or later. A subset of POAG with juvenile onset has recently been linked to chromosome 1q in two families with autosomal dominant inheritance. Eleven pedigrees with autosomal dominant POG (non-juvenile-onset) have been identified in Epirus, Greece. In the present study DNA samples have been collected from 50 individuals from one large pedigree, including 12 affected individuals. Preliminary results of linkage analysis with chromosome 1 microsatellites using the computer program package LINKAGE Version 5.1 showed no linkage with the markers previously linked to juvenile-onset POAG. Further linkage analysis is being pursued, and the results will be presented.

  16. Noninvasive diagnosis of hypolactasia with 4-Galactosylxylose (Gaxilose): a multicentre, open-label, phase IIB-III nonrandomized trial.

    PubMed

    Aragón, Juan J; Hermida, Carmen; Martínez-Costa, Oscar H; Sánchez, Valentina; Martín, Igor; Sánchez, José J; Codoceo, Rosa; Cano, José M; Cano, Ana; Crespo, Laura; Torres, Yolanda; García, Francisco J; Fernández-Mayoralas, Alfonso; Solera, Jesús; Martínez, Pilar

    2014-01-01

    Hypolactasia affects over half of the world population. Diagnosis remains problematic as currently available tests, such as the hydrogen breath test, have low reliability and lactose intolerance symptoms are unspecific. We evaluated the diagnostic performance and safety of a new noninvasive diagnostic test based on urine or serum measurement of D-xylose after lactase cleavage of orally administered 4-galactosylxylose (gaxilose). In a multicentre, open-label, nonrandomized, phase IIb-III study, consecutive patients with symptoms suggestive of lactose intolerance sequentially underwent intestinal biopsy for direct measurement of lactase activity (reference standard), hydrogen breath test, and blood glucose test after lactose challenge, 4- and 5-hour urine-based gaxilose test, and blood-based gaxilose test. For the gaxilose tests, 0 to 4 and 4 to 5 hours urine samples were taken after a 0.45 g gaxilose dose, whereas serum samples were taken 90 minutes after a 2.7 g dose for D-xylose determination. Genetic testing of hypolactasia was also assessed. Of the 222 patients enrolled, 203 completed all diagnostic tests; 108 were hypolactasic according to biopsy. The sensitivities and specificities and positive and negative predictive values of the gaxilose tests were all >90% versus 69% to 85% for the hydrogen breath test and the blood glucose test. The area under the ROC curve was significantly higher for the gaxilose tests (>0.9, P≤0.007). These tests also had higher sensitivity than genetic testing for hypolactasia and were well tolerated. The diagnostic performance of the gaxilose tests is excellent and can substantially improve the diagnosis of hypolactasia.

  17. Modified maxillary protraction headgear for the correction of class III skeletal malocclusion with anterior open bite.

    PubMed

    Qazi, Haroon Shahid; Amjad, Al-Taki

    2005-12-01

    This is a case report of a 10-year-old girl with a hyper divergent class III skeletal malocclusion caused primarily due to maxillary retrognathism. Treatment involved the use of a modified maxillary protraction face mask that carries the point of force application extra orally to pass through the centre of resistance of the maxillary dentoalveolar complex. After 8 months, the maxilla was displaced anteriorly without rotation. Maxillary occlusal plane showed a clockwise rotation. Maxillary incisors were extruded and retroclined. Mandible was displaced downward and backward. Another 18 months were required for fixed orthodontic treatment to achieve perfect interdigitation.

  18. [The research protocol III. Study population].

    PubMed

    Arias-Gómez, Jesús; Villasís-Keever, Miguel Ángel; Miranda-Novales, María Guadalupe

    2016-01-01

    The study population is defined as a set of cases, determined, limited, and accessible, that will constitute the subjects for the selection of the sample, and must fulfill several characteristics and distinct criteria. The objectives of this manuscript are focused on specifying each one of the elements required to make the selection of the participants of a research project, during the elaboration of the protocol, including the concepts of study population, sample, selection criteria and sampling methods. After delineating the study population, the researcher must specify the criteria that each participant has to comply. The criteria that include the specific characteristics are denominated selection or eligibility criteria. These criteria are inclusion, exclusion and elimination, and will delineate the eligible population. The sampling methods are divided in two large groups: 1) probabilistic or random sampling and 2) non-probabilistic sampling. The difference lies in the employment of statistical methods to select the subjects. In every research, it is necessary to establish at the beginning the specific number of participants to be included to achieve the objectives of the study. This number is the sample size, and can be calculated or estimated with mathematical formulas and statistic software.

  19. Interdisciplinary Studies Program. Teacher's Guide: Part III.

    ERIC Educational Resources Information Center

    Valencia Community Coll., Orlando, FL.

    This teacher's guide was developed for the third of four courses in Valencia Community College's Interdisciplinary Studies program, a 2-year core general education curriculum which chronologically examines the major developments in the evolution of human knowledge. The guide provides an introductory overview of the course's topic (i.e., Western…

  20. Histidinaemia. Part III: Impact; a prospective study.

    PubMed

    Coulombe, J T; Kammerer, B L; Levy, H L; Hirsch, B Z; Scriver, C R

    1983-01-01

    We describe a prospective study of histidinaemia. Probands and siblings (n = 21) with typical histidinaemia in 16 families were ascertained by newborn screening; diagnosis was confirmed by appropriate investigations in each subject; none had been treated by low histidine diet. The median age of subjects with histidinaemia was 9.5 y (mean 10.0, SD 3.5, range 6-18). Age-matched sib-pairs and their mothers were studied. IQ scores (Full Scale, Verbal and Performance Scores), Visual-Motor Integration Performance (Bender Gestalt and Koppitz scores), Wide Range Achievement Test (Reading and Mathematics), school performance, and psychological history were evaluated, as well as the medical history (pregnancy, delivery, neonatal, post-natal development). Findings were correlated with biochemical phenotype. CNS development in histidinaemic subjects (mean and distribution of scores) was normal; outlier values did not correlate with degree of histidinaemia. We can conclude that histidinaemia detected by newborn screening is a non-disadaptive phenotype.

  1. [Clinical research III. The causality studies].

    PubMed

    Talavera, Juan O; Wacher-Rodarte, Niels H; Rivas-Ruiz, Rodolfo

    2011-01-01

    The need to solve a clinical problem leads us to establish a starting point to address (risk, prognosis or treatment studies), all these cases seek to attribute causality. Clinical reasoning described in the book Clinical Epidemiology. The architecture of clinical research, offers a simple guide to understanding this phenomenon. And proposes three basic components: baseline, maneuver and outcome. In this model, different systematic errors (bias) are described, which may be favored by omitting characteristics of the three basic components. Thus, omissions in the baseline characteristics cause an improper assembly of the population and susceptibility bias, omissions in the application or evaluation of the maneuver provoke performance bias, and omissions in the assessment of out-come cause detection bias and transfer bias. Importantly, if this way of thinking facilitates understanding of the causal phenomenon, the appropriateness of the variables to be selected in the studies to which attribute or not causality, require additional arguments for evaluate clinical relevance.

  2. Studies on the corona of open clusters

    NASA Astrophysics Data System (ADS)

    Balaguer-Núñez, L.; Jordi, C.; Muiños, J. L.; Galadí-Enríquez, D.; Masana, E.

    2013-05-01

    High quality proper motions on an extended area of a selection of Open Clusters (OCs) will let us study their coronas with unprecedented accuracy. We are in the process of obtaining astrometry with the Meridian Circles of San Fernando CMASF at El Leoncito (Argentina) and the CTA at La Palma of an area few times the known radius (from Webda) of a selection of OCs. We will make use of Strömgren wide-field photometry to complement their characterization. We have already analysed the old open cluster M67, deriving properties for 2738 stars fainter and, in a wider area, than any previous precise survey in the cluster region. With new data from the CMASF we have covered an area of about 2°×1.4° and down to 17 magnitude in r^'. Proper motions are then used to determine the membership probabilities of stars in the region, applying parametric and non-parametric approaches to cluster/field segregation. Adding photometric criteria, we obtained a preliminary list of 665 probable member stars, up to a distance 0.96° from the cluster centre. These are preliminary results on our work that will lead us to the most complete study of its structure, dynamics and mass segregation up to date. We have already obtained proper motions for NGC 1817, NGC 2264 and NGC 2509 that are now being processed.

  3. Management of Gustilo Anderson III B open tibial fractures by primary fascio-septo-cutaneous local flap and primary fixation: The ‘fix and shift’ technique

    PubMed Central

    Ramasamy, P R

    2017-01-01

    Background: Open fractures of tibia have posed great difficulty in managing both the soft tissue and the skeletal components of the injured limb. Gustilo Anderson III B open tibial fractures are more difficult to manage than I, II, and III A fractures. Stable skeletal fixation with immediate soft tissue cover has been the key to the successful outcome in treating open tibial fractures, in particular, Gustilo Anderson III B types. If the length of the open wound is larger and if the exposed surface of tibial fracture and tibial shaft is greater, then the management becomes still more difficult. Materials and Methods: Thirty six Gustilo Anderson III B open tibial fractures managed between June 2002 and December 2013 with “fix and shift” technique were retrospectively reviewed. All the 36 patients managed by this technique had open wounds measuring >5 cm (post debridement). Under fix and shift technique, stable fixation involved primary external fixator application or primary intramedullary nailing of the tibial fracture and immediate soft tissue cover involved septocutaneous shift, i.e., shifting of fasciocutaneous segments based on septocutaneous perforators. Results: Primary fracture union rate was 50% and reoperation rate (bone stimulating procedures) was 50%. Overall fracture union rate was 100%. The rate of malunion was 14% and deep infection was 16%. Failure of septocutaneous shift was 2.7%. There was no incidence of amputation. Conclusion: Management of Gustilo Anderson III B open tibial fractures with “fix and shift” technique has resulted in better outcome in terms of skeletal factors (primary fracture union, overall union, and time for union and malunion) and soft tissue factors (wound healing, flap failure, access to secondary procedures, and esthetic appearance) when compared to standard methods adopted earlier. Hence, “fix and shift” could be recommended as one of the treatment modalities for open III B tibial fractures. PMID:28216752

  4. Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial.

    PubMed

    Ellis, Paul; Barrett-Lee, Peter; Johnson, Lindsay; Cameron, David; Wardley, Andrew; O'Reilly, Susan; Verrill, Mark; Smith, Ian; Yarnold, John; Coleman, Robert; Earl, Helena; Canney, Peter; Twelves, Chris; Poole, Christopher; Bloomfield, David; Hopwood, Penelope; Johnston, Stephen; Dowsett, Mitchell; Bartlett, John M S; Ellis, Ian; Peckitt, Clare; Hall, Emma; Bliss, Judith M

    2009-05-16

    Incorporation of a taxane as adjuvant treatment for early breast cancer offers potential for further improvement of anthracycline-based treatment. The UK TACT study (CRUK01/001) investigated whether sequential docetaxel after anthracycline chemotherapy would improve patient outcome compared with standard chemotherapy of similar duration. In this multicentre, open-label, phase III, randomised controlled trial, 4162 women (aged >18 years) with node-positive or high-risk node-negative operable early breast cancer were randomly assigned by computer-generated permuted block randomisation to receive FEC (fluorouracil 600 mg/m(2), epirubicin 60 mg/m(2), cyclophosphamide 600 mg/m(2) at 3-weekly intervals) for four cycles followed by docetaxel (100 mg/m(2) at 3-weekly intervals) for four cycles (n=2073) or control (n=2089). For the control regimen, centres chose either FEC for eight cycles (n=1265) or epirubicin (100 mg/m(2) at 3-weekly intervals) for four cycles followed by CMF (cyclophosphamide 600 mg/m(2), methotrexate 40 mg/m(2), and fluorouracil 600 mg/m(2) at 4-weekly intervals) for four cycles (n=824). The primary endpoint was disease-free survival. Analysis was by intention to treat (ITT). This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN79718493. All randomised patients were included in the ITT population. With a median follow-up of 62 months, disease-free survival events were seen in 517 of 2073 patients in the experimental group compared with 539 of 2089 controls (hazard ratio [HR] 0.95, 95% CI 0.85-1.08; p=0.44). 75.6% (95% CI 73.7-77.5) of patients in the experimental group and 74.3% (72.3-76.2) of controls were alive and disease-free at 5 years. The proportion of patients who reported any acute grade 3 or 4 adverse event was significantly greater in the experimental group than in the control group (p<0.0001); the most frequent events were neutropenia (937 events vs 797 events), leucopenia (507 vs 362), and

  5. Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial

    PubMed Central

    Ellis, Paul; Barrett-Lee, Peter; Johnson, Lindsay; Cameron, David; Wardley, Andrew; O'Reilly, Susan; Verrill, Mark; Smith, Ian; Yarnold, John; Coleman, Robert; Earl, Helena; Canney, Peter; Twelves, Chris; Poole, Christopher; Bloomfield, David; Hopwood, Penelope; Johnston, Stephen; Dowsett, Mitchell; Bartlett, John MS; Ellis, Ian; Peckitt, Clare; Hall, Emma; Bliss, Judith M

    2009-01-01

    Summary Background Incorporation of a taxane as adjuvant treatment for early breast cancer offers potential for further improvement of anthracycline-based treatment. The UK TACT study (CRUK01/001) investigated whether sequential docetaxel after anthracycline chemotherapy would improve patient outcome compared with standard chemotherapy of similar duration. Methods In this multicentre, open-label, phase III, randomised controlled trial, 4162 women (aged >18 years) with node-positive or high-risk node-negative operable early breast cancer were randomly assigned by computer-generated permuted block randomisation to receive FEC (fluorouracil 600 mg/m2, epirubicin 60 mg/m2, cyclophosphamide 600 mg/m2 at 3-weekly intervals) for four cycles followed by docetaxel (100 mg/m2 at 3-weekly intervals) for four cycles (n=2073) or control (n=2089). For the control regimen, centres chose either FEC for eight cycles (n=1265) or epirubicin (100 mg/m2 at 3-weekly intervals) for four cycles followed by CMF (cyclophosphamide 600 mg/m2, methotrexate 40 mg/m2, and fluorouracil 600 mg/m2 at 4-weekly intervals) for four cycles (n=824). The primary endpoint was disease-free survival. Analysis was by intention to treat (ITT). This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN79718493. Findings All randomised patients were included in the ITT population. With a median follow-up of 62 months, disease-free survival events were seen in 517 of 2073 patients in the experimental group compared with 539 of 2089 controls (hazard ratio [HR] 0·95, 95% CI 0·85–1·08; p=0·44). 75·6% (95% CI 73·7–77·5) of patients in the experimental group and 74·3% (72·3–76·2) of controls were alive and disease-free at 5 years. The proportion of patients who reported any acute grade 3 or 4 adverse event was significantly greater in the experimental group than in the control group (p<0·0001); the most frequent events were neutropenia (937 events vs 797 events

  6. Separation studies of As(III), Sb(III) and Bi(III) by reversed-phase paper chromatographic technique

    SciTech Connect

    Raman, B.; Shinde, V.M.

    1987-07-01

    Reversed-phase paper chromatographic separations of As(III), Sb(III) and Bi(III) have been carried out on Whatman No 1 filter paper impregnated with triphenylphosphine oxide as stationary phase and using organic complexing agents such as sodium acetate, sodium succinate and sodium malonate solutions as active mobile phases. Results for the separation of binary and ternary mixtures are reported and the method has been successfully applied to the separation and detection of these elements present in real samples and at ppm level concentration.

  7. Clinical efficacy and prognosis factors of open calcaneal fracture: a retrospective study

    PubMed Central

    Zhang, Xuebin; Liu, Yueju; Peng, Aqin; Wang, Haili; Zhang, Yingze

    2015-01-01

    Background: Treatment of open calcaneal fractures remains to be a challenge for orthopaedic surgeons. The aim of this study is to assess factors affecting the treatment results of open calcaneal fractures. Methods: A total of 98 patients who have 101 open calcaneal fractures were recruited in our hospital, they were all treated with a standard protocol based on the appearance of the traumatic wound. Data on mechanism of injury, location and size of wound, classification, fixation methods and subsequent soft-tissue complications were collected and evaluated. AOFAS Ankle-Hindfoot Survey and physical examinations were performed to access outcomes. Results: No statistical difference was found in complication and AOFAS score in open calcaneal fractures treated with different fixation, and no statistical difference was found in AOFAS between gustilo I and II type open calcaneal fractures (P > 0.05). There was significant difference between gustilo I and III type or gustilo II and III type fractures (P < 0.05). The more serious soft tissue injury of open calcaneal fracture lead to the worse outcome and higher incidence of complications obtained. Conclusion: Open calcaneal fractures have a high propensity for soft-tissue complications no matter which fixation method was chose. There was no significant difference between patients who had been treated with different fixations in complication rates. Soft-tissue injury played an important role in outcomes of open calcaneal fractures. Deep infections and osteomyelitis were rare by means of emergency debridement and following repeated debridement. PMID:26064282

  8. Effect of Laparoscopic-Assisted Resection vs Open Resection of Stage II or III Rectal Cancer on Pathologic Outcomes

    PubMed Central

    Fleshman, James; Branda, Megan; Sargent, Daniel J.; Boller, Anne Marie; George, Virgilio; Abbas, Maher; Peters, Walter R.; Maun, Dipen; Chang, George; Herline, Alan; Fichera, Alessandro; Mutch, Matthew; Wexner, Steven; Whiteford, Mark; Marks, John; Birnbaum, Elisa; Margolin, David; Larson, David; Marcello, Peter; Posner, Mitchell; Read, Thomas; Monson, John; Wren, Sherry M.; Pisters, Peter W. T.; Nelson, Heidi

    2016-01-01

    IMPORTANCE Evidence about the efficacy of laparoscopic resection of rectal cancer is incomplete, particularly for patients with more advanced-stage disease. OBJECTIVE To determine whether laparoscopic resection is noninferior to open resection, as determined by gross pathologic and histologic evaluation of the resected proctectomy specimen. DESIGN, SETTING, AND PARTICIPANTS A multicenter, balanced, noninferiority, randomized trial enrolled patients between October 2008 and September 2013. The trial was conducted by credentialed surgeons from 35 institutions in the United States and Canada. A total of 486 patients with clinical stage II or III rectal cancer within 12 cm of the anal verge were randomized after completion of neoadjuvant therapy to laparoscopic or open resection. INTERVENTIONS Standard laparoscopic and open approaches were performed by the credentialed surgeons. MAIN OUTCOMES AND MEASURES The primary outcome assessing efficacy was a composite of circumferential radial margin greater than 1 mm, distal margin without tumor, and completeness of total mesorectal excision. A 6%noninferiority margin was chosen according to clinical relevance estimation. RESULTS Two hundred forty patients with laparoscopic resection and 222 with open resection were evaluable for analysis of the 486 enrolled. Successful resection occurred in 81.7%of laparoscopic resection cases (95%CI, 76.8%–86.6%) and 86.9%of open resection cases (95%CI, 82.5%–91.4%) and did not support noninferiority (difference, −5.3%; 1-sided 95%CI, −10.8%to ∞; P for noninferiority = .41). Patients underwent low anterior resection (76.7%) or abdominoperineal resection (23.3%). Conversion to open resection occurred in 11.3%of patients. Operative time was significantly longer for laparoscopic resection (mean, 266.2 vs 220.6 minutes; mean difference, 45.5 minutes; 95%CI, 27.7–63.4; P < .001). Length of stay (7.3 vs 7.0 days; mean difference, 0.3 days; 95%CI, −0.6 to 1.1), readmission within 30

  9. Nursing III. A Course of Study. Health Occupations Education.

    ERIC Educational Resources Information Center

    Rogers, Helen V.

    This curriculum guide for instructors provides a course of study (Nursing III) requisite for the third and concluding portion of a 1-year practical nursing curriculum designed to continue opportunities for career mobility in the health occupations. Content is in three sections: (1) Medical Surgical Nursing II, (2) Mental Health Nursing, and (3)…

  10. Nursing III. A Course of Study. Health Occupations Education.

    ERIC Educational Resources Information Center

    Rogers, Helen V.

    This curriculum guide for instructors provides a course of study (Nursing III) requisite for the third and concluding portion of a 1-year practical nursing curriculum designed to continue opportunities for career mobility in the health occupations. Content is in three sections: (1) Medical Surgical Nursing II, (2) Mental Health Nursing, and (3)…

  11. Three-dimensional open-frameworks based on Ln(III) ions and open-/closed-shell PTM ligands: synthesis, structure, luminescence, and magnetic properties.

    PubMed

    Datcu, Angela; Roques, Nans; Jubera, Véronique; Imaz, Inhar; Maspoch, Daniel; Sutter, Jean-Pascal; Rovira, Concepció; Veciana, Jaume

    2011-03-21

    A series of isostructural open-framework coordination polymers formulated as [Ln(dmf)(3)(ptmtc)] (Ln = Sm (1), Eu (2), Gd (3), Tb (4), Dy (5); PTMTC = polychlorotriphenylmethyl tricarboxylate) and [Ln(dmf)(2)H(2)O(αH-ptmtc)] (Ln = Sm (1'), Eu (2'), Gd (3'), Tb (4'), Dy (5')) have been obtained by treating Ln(III) ions with PTMTC ligands with a radical (PTMTC(3-)) or a closed-shell character (αH-PTMTC(3-)). X-ray diffraction analyses reveal that these coordination polymers possess 3D architectures that combine large channels and fairly rare lattice complex T connectivity. In addition, these compounds show selective framework dynamic sorption properties. For both classes of ligands, the ability to act as an antenna in Ln sensitization processes has been investigated. No luminescence was observed for compounds 1-5, and 3' because of the PTMTC(3-) ligand and/or Gd(III) ion characteristics. Conversely, photoluminescence measurements show that 1', 2', 4', and 5' emit dark orange, red, green, and dark cyan metal-centered luminescence. The magnetic properties of all of these compounds have been investigated. The nature of the {Ln-radical} exchange interaction in these compounds has been assessed by comparing the behavior of the radical-based coordination polymers 1-5 with those of the compounds with the diamagnetic ligand set. While antiferromagnetic {Sm-radical} interactions are found in 1, ferromagnetic {Ln-radical} interactions propagate in the 3D architectures of 3, 4, and 5 (Ln = Gd, Tb, and Dy, respectively). This procedure also provided access to information on the {Ln-Ln} exchange existing in these magnetic systems.

  12. 1,2,4-Diazaphospholide complexes of lanthanum(iii), cerium(iii), neodymium(iii), praseodymium(iii), and samarium(iii): synthesis, X-ray structural characterization, and magnetic susceptibility studies.

    PubMed

    Zhao, Minggang; Wang, Lixia; Li, Pangpang; Ma, Jianping; Zheng, Wenjun

    2016-07-05

    A few heteroleptic, charge-separated heterobimetallic, and polymeric alkali metalate complexes of 1,2,4-diazaphospholide lanthanum(iii), cerium(iii), neodymium(iii), praseodymium(iii), and samarium(iii) were simply prepared via the metathesis reaction of MCl3 (THF)m (m = 1-2) and K[3,5-R2dp] ([3,5-R2dp](-) = 3,5-di-substituent-1,2,4-diazaphospholide; R = tBu, Ph) in a varied ratio (1 : 3, 1 : 4, and 1 : 5, respectively) at room temperature in tetrahydrofuran. All the complexes were fully characterized by (1)H, (13)C{(1)H}, (31)P{(1)H}, IR, and X-ray single crystal diffraction analysis despite their paramagnetism (excluding La(iii) complexes). The structures of the complexes were found to feature varied coordination modes. The magnetic properties of several compounds were studied by magnetic susceptibility, and the complexes presented the magnetic moments close to or lower than the theoretical values for the free ions in the trivalent oxidation states (Pr(3+), Nd(3+)).

  13. The Xanthomonas campestris Type III Effector XopJ Proteolytically Degrades Proteasome Subunit RPT61[OPEN

    PubMed Central

    2015-01-01

    Many animal and plant pathogenic bacteria inject type III effector (T3E) proteins into their eukaryotic host cells to suppress immunity. The Yersinia outer protein J (YopJ) family of T3Es is a widely distributed family of effector proteins found in both animal and plant pathogens, and its members are highly diversified in virulence functions. Some members have been shown to possess acetyltransferase activity; however, whether this is a general feature of YopJ family T3Es is currently unknown. The T3E Xanthomonas outer protein J (XopJ), a YopJ family effector from the plant pathogen Xanthomonas campestris pv vesicatoria, interacts with the proteasomal subunit Regulatory Particle AAA-ATPase6 (RPT6) in planta to suppress proteasome activity, resulting in the inhibition of salicylic acid-related immune responses. Here, we show that XopJ has protease activity to specifically degrade RPT6, leading to reduced proteasome activity in the cytoplasm as well as in the nucleus. Proteolytic degradation of RPT6 was dependent on the localization of XopJ to the plasma membrane as well as on its catalytic triad. Mutation of the Walker B motif of RPT6 prevented XopJ-mediated degradation of the protein but not XopJ interaction. This indicates that the interaction of RPT6 with XopJ is dependent on the ATP-binding activity of RPT6, but proteolytic cleavage additionally requires its ATPase activity. Inhibition of the proteasome impairs the proteasomal turnover of Nonexpressor of Pathogenesis-Related1 (NPR1), the master regulator of salicylic acid responses, leading to the accumulation of ubiquitinated NPR1, which likely interferes with the full induction of NPR1 target genes. Our results show that YopJ family T3Es are not only highly diversified in virulence function but also appear to possess different biochemical activities. PMID:25739698

  14. OpenARC: Extensible OpenACC Compiler Framework for Directive-Based Accelerator Programming Study

    SciTech Connect

    Lee, Seyong; Vetter, Jeffrey S

    2014-01-01

    Directive-based, accelerator programming models such as OpenACC have arisen as an alternative solution to program emerging Scalable Heterogeneous Computing (SHC) platforms. However, the increased complexity in the SHC systems incurs several challenges in terms of portability and productivity. This paper presents an open-sourced OpenACC compiler, called OpenARC, which serves as an extensible research framework to address those issues in the directive-based accelerator programming. This paper explains important design strategies and key compiler transformation techniques needed to implement the reference OpenACC compiler. Moreover, this paper demonstrates the efficacy of OpenARC as a research framework for directive-based programming study, by proposing and implementing OpenACC extensions in the OpenARC framework to 1) support hybrid programming of the unified memory and separate memory and 2) exploit architecture-specific features in an abstract manner. Porting thirteen standard OpenACC programs and three extended OpenACC programs to CUDA GPUs shows that OpenARC performs similarly to a commercial OpenACC compiler, while it serves as a high-level research framework.

  15. Synthesis of Imine-Naphthol Tripodal Ligand and Study of Its Coordination Behaviour towards Fe(III), Al(III), and Cr(III) Metal Ions

    PubMed Central

    Kaur, Kirandeep

    2014-01-01

    A hexadentate Schiff base tripodal ligand is synthesized by the condensation of tris (2-aminoethyl) amine with 2-hydroxy-1-naphthaldehyde and characterized by various spectroscopic techniques like UV-VIS, IR, NMR, MASS, and elemental analysis. The solution studies by potentiometric and spectrophotometric methods are done at 25 ± 1°C, µ = 0.1 M KCl, to calculate the protonation constants of the ligand and formation constants of metal complexes formed by the ligand with Fe(III), Al(III), and Cr(III) metal ions. The affinity of the ligand towards Fe(III) is compared with deferiprone (a drug applied for iron intoxication) and transferrin (the main Fe(III) binding protein in plasma). Structural analysis of the ligand and the metal complexes was done using semiempirical PM6 method. Electronic and IR spectra are calculated by semiempirical methods and compared with experimental one. PMID:25294978

  16. Does the zone of injury in combat-related Type III open tibia fractures preclude the use of local soft tissue coverage?

    PubMed

    Burns, Travis C; Stinner, Daniel J; Possley, Daniel R; Mack, Andrew W; Eckel, Tobin T; Potter, Benjamin K; Wenke, Joseph C; Hsu, Joseph R

    2010-11-01

    Does the large zone of injury in high-energy, combat-related open tibia fractures limit the effectiveness of rotational flap coverage? Retrospective consecutive series. This study was conducted at Brooke Army Medical Center, Walter Reed Army Medical Center, and National Naval Medical Center between March 2003 and September 2007. We identified 67 extremities requiring a coverage procedure out of 213 consecutive combat-related Type III open diaphyseal tibia fractures. The 67 Type III B tibia fractures were treated with rotational or free flap coverage. Flap failure, reoperation, infection, amputation, time to union, and visual pain scale. There were no differences between the free and rotational flap cohorts with respect to demographic information, injury characteristics, or treatment before coverage. The reoperation and amputation rates were significantly lower for the rotational coverage group (30% and 9%) compared with the free flap group (64% and 36%; P = 0.05 and P = 0.03, respectively). The coverage failure rate was also lower for the rotational flap cohort (7% versus 27%, P = 0.08). The average time to fracture union for the free flap group was 9.5 months (range, 5-15.8 months) and 10.5 months (range, 3-41 months) for the rotational flap group (P = 0.99). There was a significantly lower amputation and reoperation rate for patients treated with rotational coverage. Contrary to our hypothesis and previous reports, the zone of injury in combat-related open tibia fractures does not preclude the use of local rotational coverage when practicable.

  17. Novel approaches to incorporating pharmacoeconomic studies into phase III clinical trials for Alzheimer's disease.

    PubMed

    Fillit, H; Cummings, J; Neumann, P; McLaughlin, T; Salavtore, P; Leibman, C

    2010-10-01

    The societal and individual costs of Alzheimer's disease are significant, worldwide. As the world ages, these costs are increasing rapidly, while health systems face finite budgets. As a result, many regulators and payers will require or at least consider phase III cost-effectiveness data (in addition to safety and efficacy data) for drug approval and reimbursement, increasing the risks and costs of drug development. Incorporating pharmacoeconomic studies in phase III clinical trials for Alzheimer's disease presents a number of challenges. We propose several specific suggestions to improve the design of pharmacoeconomic studies in phase III clinical trials. We propose that acute episodes of care are key outcome measures for pharmacoeconomic studies. To improve the possibility of detecting a pharmacoeconomic impact in phase III, we suggest several strategies including; study designs for enrichment of pharmacoeconomic outcomes that include co-morbidity of patients; reducing variability of care that can affect pharmacoeconomic outcomes through standardized care management; employing administrative claims data to better capture meaningful pharmacoeconomic data; and extending clinical trials in open label follow-up periods in which pharmacoeconomic data are captured electronically by administrative claims. Specific aspects of power analysis for pharmacoeconomic studies are presented. The particular pharmacoeconomic challenges caused by the use of biomarkers in clinical trials, the increasing use of multinational studies, and the pharmacoeconomic challenges presented by biologicals in development for Alzheimer's disease are discussed. In summary, since we are entering an era in which pharmacoeconomic studies will be essential in drug development for supporting regulatory approval, payor reimbursement and integration of new therapies into clinical care, we must consider the design and incorporation of pharmacoeconomic studies in phase III clinical trials more seriously

  18. Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates.

    PubMed

    Refat, Moamen S; Al-Azab, Fathi M; Al-Maydama, Hussein M A; Amin, Ragab R; Jamil, Yasmin M S; Kobeasy, Mohamed I

    2015-05-05

    Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E(∗), ΔH(∗), ΔS(∗) and ΔG(∗) were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Al-Azab, Fathi M.; Al-Maydama, Hussein M. A.; Amin, Ragab R.; Jamil, Yasmin M. S.; Kobeasy, Mohamed I.

    2015-05-01

    Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E∗, ΔH∗, ΔS∗ and ΔG∗ were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi.

  20. Hexaammine Complexes of Cr(III) and Co(III): A Spectral Study.

    ERIC Educational Resources Information Center

    Brown, D. R.; Pavlis, R. R.

    1985-01-01

    Procedures are provided for experiments containing complex ions with octahedral symmetry, hexaamminecobalt(III) chloride and hexaamminechromium(III) nitrate, so students can interpret fully the ultra violet/visible spectra of the complex cations in terms of the ligand field parameters, 10 "Dq," the Racah interelectron repulsion parameters, "B,"…

  1. Hexaammine Complexes of Cr(III) and Co(III): A Spectral Study.

    ERIC Educational Resources Information Center

    Brown, D. R.; Pavlis, R. R.

    1985-01-01

    Procedures are provided for experiments containing complex ions with octahedral symmetry, hexaamminecobalt(III) chloride and hexaamminechromium(III) nitrate, so students can interpret fully the ultra violet/visible spectra of the complex cations in terms of the ligand field parameters, 10 "Dq," the Racah interelectron repulsion parameters, "B,"…

  2. A Study of Clinically Related Open Source Software Projects

    PubMed Central

    Hogarth, Michael A.; Turner, Stuart

    2005-01-01

    Open source software development has recently gained significant interest due to several successful mainstream open source projects. This methodology has been proposed as being similarly viable and beneficial in the clinical application domain as well. However, the clinical software development venue differs significantly from the mainstream software venue. Existing clinical open source projects have not been well characterized nor formally studied so the ‘fit’ of open source in this domain is largely unknown. In order to better understand the open source movement in the clinical application domain, we undertook a study of existing open source clinical projects. In this study we sought to characterize and classify existing clinical open source projects and to determine metrics for their viability. This study revealed several findings which we believe could guide the healthcare community in its quest for successful open source clinical software projects. PMID:16779056

  3. Protection of open-metal V(III) sites and their associated CO₂/CH₄/N₂/O₂/H₂O adsorption properties in mesoporous V-MOFs.

    PubMed

    Yang, Jiangfeng; Wang, Yong; Li, Libo; Zhang, Zhuoming; Li, Jinping

    2015-10-15

    Metal-organic frameworks with open metal site are potential sorbents for the separation of gas mixtures; however, low valence metal will bind to oxygen in the open air causing a decrease in adsorption ability. We now report open-metal sites V(III) on both MIL-100V(III/IV) and MIL-101V(III/IV) that can be protected with water molecules, and which associated CO2/CH4/N2/O2 adsorption properties on these two mesoporous V-MOFs were investigated. The protective properties of water were investigated and evaluated using density functional theory simulations. The binding energy of single O2 on open-metal V(III) site was 93.278 kJ/mol, which decreased to 26.5 kJ/mol when H2O occupies the site. When the water coating is removed, the X-ray photoelectron spectroscopy pattern of V2p showed that the V-MOF changes to MIL-100V(IV) and MIL-101V(IV) at 298 K because of the action of O2. Under these conditions, O2 binds strongly on the open V site significantly reducing the BET (Brunauer-Emmett-Teller) surface and CH4 adsorption volume of the V-MOFs. From the ideal adsorbed solution theory calculated, the adsorption selectivity of CH4/N2 is higher before than after binding of O2 (with V(III) site). In contrast, the adsorption selectivity of CO2/CH4 is higher after than before O2 binding (with no more V(III) sites). Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Ionization processes in collisions of open-shell atoms. III - The autoionizing states of nitrogen

    NASA Technical Reports Server (NTRS)

    Boumsellek, S.; Esaulov, V. A.

    1990-01-01

    Results of a study of the energy spectra of electrons produced in collisions of N atoms with inert gases at low keV energies are reported. Ionization here is partly due to production of the (1Dnl) autoionizing states of nitrogen and partly due to another mechanism, which is presumably quasi molecular Auger ionization. A discussion of the assignments of the autoionizing states is presented.

  5. Spectroscopic STM studies of single gold(III) porphyrin molecules.

    PubMed

    Müllegger, Stefan; Schöfberger, Wolfgang; Rashidi, Mohammad; Reith, Lorenz M; Koch, Reinhold

    2009-12-16

    Low-temperature scanning tunneling microscopy, a well-established technique for single-molecule investigations in an ultrahigh vacuum environment, has been used to study the electronic properties of Au(III) 5,10,15,20-tetraphenylporphyrin (AuTPP) molecules on Au(111) at the submolecular scale. AuTPP serves as a model system for chemotherapeutically relevant Au(III) porphyrins. For the first time, real-space images and local scanning tunneling spectroscopy data of the frontier molecular orbitals of AuTPP are presented. A comparison with results from density functional theory reveals significant deviations from gas-phase behavior due to a non-negligible molecule/substrate interaction. We identify the oxidation state of the central metal ion in the adsorbed AuTPP as Au(3+).

  6. Mark III Space Suit Mobility: A Reach Evaluation Case Study

    NASA Technical Reports Server (NTRS)

    Thaxton, Sherry S.; Abercromby, Andrew F. J.; Onady, Elizabeth A.; Rajulu, Sudhakar L.

    2007-01-01

    A preliminary assessment of the reach envelope and field of vision (FOV) for a subject wearing a Mark III space suit was requested for use in human-machine interface design of the Science Crew Operations and Utility Testbed (SCOUT) vehicle. The reach and view of two suited and unsuited subjects were evaluated while seated in the vehicle using 3-dimensional position data collected during a series of reaching motions. Data was interpolated and displayed in orthogonal views and cross-sections. Compared with unsuited conditions, medio-lateral reach was not strongly affected by the Mark III suit, whereas vertical and antero-posterior reach were inhibited by the suit. Lateral FOV was reduced by approximately 40 deg. in the suit. The techniques used in this case study may prove useful in human-machine interface design by providing a new means of developing and displaying reach envelopes.

  7. Alternative treatment for open bite Class III malocclusion in a child with Williams-Beuren syndrome.

    PubMed

    Vieira, Giovanni Modesto; Franco, Eduardo Jacomino; da Rocha, Denise Falcão Pinheiro; de Oliveira, Laudimar Alves; Amorim, Rivadávio Fernandes Batista

    2015-01-01

    Williams-Beuren syndrome (WBS) is a rare genetic condition that affects approximately 1 in every 20,000 - 50,000 live births. WBS children have specific skeletal deformities, dental malformations and rare lingual muscle dysfunction. The need for orthodontic and orthognathic therapy has arisen and has been considered a real clinical challenge even for experienced professionals, once it requires a complex and individualized treatment plan. This study reports a case of orthopedic expansion of the maxilla, in which a modified facial mask was used for protraction of the maxillary complex associated with clockwise rotation of the maxilla. In addition, special considerations about treatment time and orthopedic outcomes are discussed.

  8. Alternative treatment for open bite Class III malocclusion in a child with Williams-Beuren syndrome

    PubMed Central

    Vieira, Giovanni Modesto; Franco, Eduardo Jacomino; da Rocha, Denise Falcão Pinheiro; de Oliveira, Laudimar Alves; Amorim, Rivadávio Fernandes Batista

    2015-01-01

    Williams-Beuren syndrome (WBS) is a rare genetic condition that affects approximately 1 in every 20,000 - 50,000 live births. WBS children have specific skeletal deformities, dental malformations and rare lingual muscle dysfunction. The need for orthodontic and orthognathic therapy has arisen and has been considered a real clinical challenge even for experienced professionals, once it requires a complex and individualized treatment plan. This study reports a case of orthopedic expansion of the maxilla, in which a modified facial mask was used for protraction of the maxillary complex associated with clockwise rotation of the maxilla. In addition, special considerations about treatment time and orthopedic outcomes are discussed. PMID:25741831

  9. "Open" Software Design: A Case Study.

    ERIC Educational Resources Information Center

    McMahon, Harry; And Others

    1992-01-01

    Discusses the use of open software, i.e., software which is essentially empty of content and can be customized by users to fit their own context, and describes the development and evaluation of one such program--Bubble Dialog--by the Language Development and Hypermedia Research Group at the University of Ulster. Various applications of the…

  10. Results of the safety run-in part of the METAL (METformin in Advanced Lung cancer) study: a multicentre, open-label phase I-II study of metformin with erlotinib in second-line therapy of patients with stage IV non-small-cell lung cancer.

    PubMed

    Morgillo, Floriana; Fasano, Morena; Della Corte, Carminia Maria; Sasso, Ferdinando Carlo; Papaccio, Federica; Viscardi, Giuseppe; Esposito, Giovanna; Di Liello, Raimondo; Normanno, Nicola; Capuano, Annalisa; Berrino, Liberato; Vicidomini, Giovanni; Fiorelli, Alfonso; Santini, Mario; Ciardiello, Fortunato

    2017-01-01

    Our previous works demonstrated the ability of metformin to revert resistance to gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in non-small-cell lung cancer (NSCLC) EGFR/LKB1 wild-type (WT) cell lines. However, the optimal dose of metformin to be used in non-diabetic patients still remains to be defined. The phase I-II trial METformin in Advanced Lung cancer (METAL) was designed to identify the maximum tolerated dose and to evaluate safety and activity of metformin combined with erlotinib in second-line treatment of patients with stage IV NSCLC, whose tumours harbour the WT EGFR gene. We report results from the safety run-in part designed to detect acute toxicities, to study pharmacokinetics and to identify the recommended phase II dose (RPD) to be used for the following phase of the study. In the run-in phase, metformin treatment was administered according to a dose escalation scheme and, subsequently, combined with erlotinib. Twelve patients were enrolled. Common adverse events were diarrhoea, decreased appetite, abdominal pain, vomiting and skin toxicity, mostly reversible with symptomatic medical treatment. Dose-limiting toxicities were vomiting and diarrhoea registered in the initial cohort receiving metformin 2000 mg plus erlotinib at 150 mg die, which was declared the maximum administered dose. Only one of nine patients treated at the next lower dose of 1500 mg of metformin plus erlotinib at 150 mg experienced G3 gastrointestinal toxicity. Metformin plasma-concentration profile confirmed the trend already observed in non-diabetic population. Glycemic profiles showed stability of the blood glucose level within the physiological range for non-diabetic subjects. At a follow-up of 30 weeks, six (50%) patients experienced a disease control (5 SD and 1 partial response). The RP2D of metformin dose was defined at 1500 mg/day to be combined with erlotinib 150 mg. EudraCT number: 2014-000349-59.

  11. Study of the Electronic Surface State of III - V Compounds

    DTIC Science & Technology

    1976-03-15

    Critical Reviews in Solid State Sciences 5. 7:31 (1975), "Surface and interface electronic structure of GaAs and other III-V compounds ." (Invited...STUDY OF THE ELECTRONIC SURFACE STATE OF TIT - V COMPOUNDS . CO o EMI-ANNUAL TECHNICAL PROGRESS REPlll»; YpTceFI Principal Investigator Telephone...Chapter 2 «^Synchrotron Radiation Studies of Electronic Structure and Surface Chemistry of GaAs, GaSb, and InP-.j^ .... 4 I. Introduction 4 II. Core

  12. Openings

    PubMed Central

    Selwyn, Peter A.

    2015-01-01

    Reviewing his clinic patient schedule for the day, a physician reflects on the history of a young woman he has been caring for over the past 9 years. What starts out as a routine visit then turns into a unique opening for communication and connection. A chance glimpse out the window of the exam room leads to a deeper meditation on parenthood, survival, and healing, not only for the patient but also for the physician. How many missed opportunities have we all had, without even realizing it, to allow this kind of fleeting but profound opening? PMID:26195687

  13. Open Access on a Zero Budget: A Case Study of "Postcolonial Text": Case Studies in Open Access Publishing. Number Three

    ERIC Educational Resources Information Center

    Willinsky, John; Mendis, Ranjini

    2007-01-01

    Introduction: The founding of a new open access journal is described in terms of its use of the open source software Open Journal Systems, its contribution to a new field of inquiry and its ability to operate on a zero budget in terms of regular expenses. Method: A case study method is deployed describing the circumstances of the journal's…

  14. Comparative Studies on Periodatocuprate(II, III) and Telluratocuprate(II, III)

    NASA Astrophysics Data System (ADS)

    Mingmei, Wu; Qiang, Su; Gang, Hu; Yufang, Ren

    1995-02-01

    The crystal structures, electronic spectra, and Cu2 p XPS of Cu(III) complexes Na 4H[Cu(H 2TeO 6) 2] · 17H 2O and Na 4K[Cu (HIO 6) 2] · 12H2O have been described. The characterizations of a Cu(III) atom in a complex are as follows: (i) In a square-planar coordination, the average bond length of Cu-O is 0.183 nm, shorter than the 0.190-0.200 nm found for a Cu(II) complex. (2) The "blue shift" occurs for d-d transitions in the electronic spectrum of the Cu(III) complex compared to those of its related Cu(II) complex, resulting from the higher valence state. (3) Cu(III) compounds with CuO 4 square-planar coordination are expected to be diamagnetic whereas Cu(II) compounds to be paramagnetic. (4) Comprehensive investigations on Cu2 p XPS show that the binding energy of Cu2 p3/2 of a pure Cu(III) compound is about 2.0 eV higher than that of its corresponding Cu(II) compound: the shakeup satellites do not appear in the Cu2 p XPS for a pure diamagnetic Cu(III) compound, the same as found for a diamagnetic Ni(II) compound: the FWHM of the signal of Cu2 p XPS may become broader for Cu(III) compound because its core hole's lifetime shortens due to the higher valence state of copper.

  15. Guidance/Navigation Requirements Study Final Report. Volume III. Appendices

    DTIC Science & Technology

    1978-04-30

    AUTHORITY USAF notice, 17 Oct 1978 THIS PAGE IS UNCLASSIFIED THIS REPORT HAS BEEN DELIMITED AMD CLEARED FOR PUBLIC RELEASE UNDER DOD DIRECTIVE 5200.20 AND NO...BEST AVAILABLE COPY SAt4SO-TR-78-92 fai GuiDANcE/NAvioATIoN flEQUIVIEMIENTS STUDY FINAL REPORT , ’VOLUME III: APPIWI’UOOE, Prepve~d by: 1~6MCO#4 INC...255 West fifth Street San Pedro, California 90731 April 1978 IFinal Report Under Contract F047-1-5-C-0112 Period of Performance: May 1975 to April 1978

  16. A Study of Title III Impact on Historically Black Institutions.

    ERIC Educational Resources Information Center

    Fincher, Cameron

    The intent of this report is to examine the status and functions of the nation's historically black institutions as they have been affected by the assistance provided under Title III of the Higher Education Act of 1965. First, background to the development of Title III legislation is reviewed. Second, evaluations of Title III programs that have…

  17. Ion implantation and annealing studies in III-V nitrides

    SciTech Connect

    Zolper, J.C.; Pearton, S.J.; Williams, J.S.; Tan, H.H.; Karlicek, R.J. Jr.; Stall, R.A.

    1996-12-31

    Ion implantation doping and isolation is expected to play an enabling role for the realization of advanced III-Nitride based devices. In fact, implantation has already been used to demonstrate n- and p-type doping of GaN with Si and Mg or Ca, respectively, as well as to fabricate the first GaN junction field effect transistor. Although these initial implantation studies demonstrated the feasibility of this technique for the III-Nitride materials, further work is needed to realize its full potential. After reviewing some of the initial studies in this field, the authors present new results for improved annealing sequences and defect studies in GaN. First, sputtered AlN is shown by electrical characterization of Schottky and Ohmic contacts to be an effect encapsulant of GaN during the 1,100 C implant activation anneal. The AlN suppresses N-loss from the GaN surface and the formation of a degenerate n{sup +}-surface region that would prohibit Schottky barrier formation after the implant activation anneal. Second, they examine the nature of the defect generation and annealing sequence following implantation using both Rutherford Backscattering (RBS) and Hall characterization. They show that for a Si-dose of 1 x 10{sup 16} cm{sup {minus}2} 50% electrical donor activation is achieved despite a significant amount of residual implantation-induced damage in the material.

  18. Synthesis and spectroscopic studies of biologically active compounds derived from oxalyldihydrazide and benzil, and their Cr(III), Fe(III) and Mn(III) complexes.

    PubMed

    Singh, D P; Kumar, Ramesh; Singh, Jitender

    2009-04-01

    A new series of complexes have been synthesized by template condensation of oxalyldihydrazide and benzil in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type [M(C(32)H(24)N(8)O(4))X]X(2) where M = Cr(III), Mn(III), Fe(III) and X = Cl(-1), NO(3)(-1), CH(3)COO(-1). The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, NMR, infrared and far infrared spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry has been proposed for all these complexes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Some of these complexes have been found to exhibit remarkable antibacterial activities.

  19. A Protocol for Percutaneous Transarticular Fixation of Sanders Type II and III Calcaneal Fractures With or Without an Added Mini-Open Approach.

    PubMed

    Gamal, Osama; Shams, Ahmed; El-Sayed Semaya, Ahmad

    Intra-articular fracture of the calcaneus is one of the most displeasing fractures if not properly managed. Open reduction and internal fixation have been associated with a high incidence of postoperative soft tissue complications. Closed reduction and percutaneous fixation have resulted in a greater incidence of postoperative subtalar osteoarthritis with improper reduction of the articular surface. In the present study, a mini-open approach was used in cases of failure of articular surface restoration with closed reduction. A total of 64 feet in 57 consecutive patients with an intra-articular calcaneal fracture underwent the proposed minimally invasive surgical protocol. Of the 57 patients, 7 (12.3%) had bilateral fractures. According to Sanders classification, 33 (51.6%) fractures were type II and 31 (48.4%) were type III. Seven (12.3%) patients had wedge fractures of the dorsolumbar spine without neurologic manifestations. The postoperative evaluation included radiographs and completion of the Maryland Foot Score and visual analog scale for pain. The mean follow-up period was 16 (range 12 to 36) months. The mean operative time was 42 (range 35 to 60) minutes. The mean period until union of the fracture was 12 (range 10 to 16) weeks. The clinical results according to the Maryland Foot Score revealed 52 (81%) with satisfactory (27 excellent and 25 good) and 12 (19%) with unsatisfactory (10 fair and 2 poor) results. The mean visual analog scale score was 1.5 ± 0.3 when radiographic fracture healing was observed. Six patients (9.4%) developed superficial pin tract infections that responded to local care and parenteral antibiotic therapy and resolved completely after removal of the Kirschner wires. In conclusion, the presented surgical protocol combining closed reduction with or without an added mini-open approach and percutaneous fixation improves the functional outcome and minimizes the incidence of complications.

  20. 77 FR 40936 - 60-Day Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ...: Passport Demand Forecasting Study Phase III. OMB Control Number: None. Type of Request: Reinstatement of a... Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III ACTION: Notice of.... The data gathered from the Passport Demand Forecasting Study Phase III will be used to monitor, assess...

  1. NGC 7789: An open cluster case study

    SciTech Connect

    Overbeek, Jamie C.; Friel, Eileen D.; Pilachowski, Catherine A.; Mészáros, Szabolcs; Jacobson, Heather R.; Johnson, Christian I.

    2015-01-01

    We have obtained high-resolution spectra of 32 giants in the open cluster NGC 7789 using the Wisconsin–Indiana–Yale–NOAO Hydra spectrograph. We explore differences in atmospheric parameters and elemental abundances caused by the use of the linelist developed for the Gaia-ESO Survey (GES) compared to one based on Arcturus used in our previous work. [Fe/H] values decrease when using the GES linelist instead of the Arcturus-based linelist; these differences are probably driven by systematically lower (∼−0.1 dex) GES surface gravities. Using the GES linelist we determine abundances for 10 elements—Fe, Mg, Si, Ca, Ti, Na, Ni, Zr, Ba, and La. We find the cluster's average metallicity [Fe/H] = 0.03 ± 0.07 dex, in good agreement with literature values, and a lower [Mg/Fe] abundance than has been reported before for this cluster (0.11 ± 0.05 dex). We also find the neutron-capture element barium to be highly enhanced—[Ba/Fe] = +0.48 ± 0.08—and disparate from cluster measurements of neutron-capture elements La and Zr (−0.08 ± 0.05 and 0.08 ± 0.08, respectively). This is in accordance with recent discoveries of supersolar Ba enhancement in young clusters along with more modest enhancement of other neutron-capture elements formed in similar environments.

  2. NGC 7789: an Open Cluster Case Study

    NASA Astrophysics Data System (ADS)

    Overbeek, Jamie C.; Friel, Eileen D.; Jacobson, Heather R.; Johnson, Christian I.; Pilachowski, Catherine A.; Mészáros, Szabolcs

    2015-01-01

    We have obtained high-resolution spectra of 32 giants in the open cluster NGC 7789 using the Wisconsin-Indiana-Yale-NOAO Hydra spectrograph. We explore differences in atmospheric parameters and elemental abundances caused by the use of the linelist developed for the Gaia-ESO Survey (GES) compared to one based on Arcturus used in our previous work. [Fe/H] values decrease when using the GES linelist instead of the Arcturus-based linelist; these differences are probably driven by systematically lower (˜-0.1 dex) GES surface gravities. Using the GES linelist we determine abundances for 10 elements—Fe, Mg, Si, Ca, Ti, Na, Ni, Zr, Ba, and La. We find the cluster's average metallicity [Fe/H] = 0.03 ± 0.07 dex, in good agreement with literature values, and a lower [Mg/Fe] abundance than has been reported before for this cluster (0.11 ± 0.05 dex). We also find the neutron-capture element barium to be highly enhanced—[Ba/Fe] = +0.48 ± 0.08—and disparate from cluster measurements of neutron-capture elements La and Zr (-0.08 ± 0.05 and 0.08 ± 0.08, respectively). This is in accordance with recent discoveries of supersolar Ba enhancement in young clusters along with more modest enhancement of other neutron-capture elements formed in similar environments.

  3. Class III malocclusion with complex problems of lateral open bite and severe crowding successfully treated with miniscrew anchorage and lingual orthodontic brackets.

    PubMed

    Yanagita, Takeshi; Kuroda, Shingo; Takano-Yamamoto, Teruko; Yamashiro, Takashi

    2011-05-01

    In this article, we report the successful use of miniscrews in a patient with an Angle Class III malocclusion, lateral open bite, midline deviation, and severe crowding. Simultaneously resolving such problems with conventional Class III treatment is difficult. In this case, the treatment procedure was even more challenging because the patient preferred to have lingual brackets on the maxillary teeth. As a result, miniscrews were used to facilitate significant asymmetric tooth movement in the posterior and downward directions; this contributed to the camouflage of the skeletal mandibular protrusion together with complete resolution of the severe crowding and lateral open bite. Analysis of the jaw motion showed that irregularities in chewing movement were also resolved, and a stable occlusion was achieved. Improvements in the facial profile and dental arches remained stable at the 18-month follow-up.

  4. Angular Study of the III Type Solar Bursts by Ukrainian Decameter Heliograph of UTR-2

    NASA Astrophysics Data System (ADS)

    Koval, Artem; Stanislavsky, Aleksander; Konovalenko, Aleksander

    2014-05-01

    corona at decameter wavelengths during low solar activity. We present new results of decameter measurements of type III bursts obtained by the radio heliograph in the frequency range 16.5-33 MHz. The series of such observations were carried out in the summer of 2013 accompanied by numerous type III solar bursts. We report about the angular structure evolution of type III burst sources in frequency and time, i.e. UV-plane viz. heights of corona in dependence of time. The heliograms clearly show directions of the source motion for type III bursts. The results open new perspectives to establish the position and the motion of radio sources of any type in solar corona. This is especially important, for example, for the study of coronal mass ejections to determine immediately directions of their motion in upper corona. New improvements and recent development of this instrument are discussed.

  5. A new chiral Fe(III)-salen grafted mesoporous catalyst for enantioselective asymmetric ring opening of racemic epoxides at room temperature under solvent-free conditions.

    PubMed

    Roy, Susmita; Bhanja, Piyali; Safikul Islam, Sk; Bhaumik, Asim; Islam, Sk Manirul

    2016-01-31

    We have designed a new mesoporous SBA-15 supported chiral Fe(III)-salen material (Fe@SBSAL) having high BET surface area and porosity. The material showed excellent catalytic efficiency in regio- and enantioselective (ee > 99%) asymmetric ring opening (ARO) of racemic meso- and terminal-epoxides with various anilines at room temperature under solvent-free conditions within 1-3 h reaction time.

  6. Different Interaction Mechanisms of Eu(III) and (243)Am(III) with Carbon Nanotubes Studied by Batch, Spectroscopy Technique and Theoretical Calculation.

    PubMed

    Wang, Xiangxue; Yang, Shubin; Shi, Weiqun; Li, Jiaxing; Hayat, Tasawar; Wang, Xiangke

    2015-10-06

    Herein the sorption of Eu(III) and (243)Am(III) on multiwalled carbon nanotubes (CNTs) are studied, and the results show that Eu(III) and (243)Am(III) could form strong inner-sphere surface complexes on CNT surfaces. However, the sorption of Eu(III) on CNTs is stronger than that of (243)Am(III) on CNTs, suggesting the difference in the interaction mechanisms or properties of Eu(III) and (243)Am(III) with CNTs, which is quite different from the results of Eu(III) and (243)Am(III) interaction on natural clay minerals and oxides. On the basis of the results of density functional theory calculations, the binding energies of Eu(III) on CNTs are much higher than those of (243)Am(III) on CNTs, indicating that Eu(III) could form stronger complexes with the oxygen-containing functional groups of CNTs than (243)Am(III), which is in good agreement with the experimental results of higher sorption capacity of CNTs for Eu(III). The oxygen-containing functional groups contribute significantly to the uptake of Eu(III) and (243)Am(III), and the binding affinity increases in the order of ≡S-OH < ≡S-COOH < ≡S-COO(-). This paper highlights the interaction mechanism of Eu(III) and (243)Am(III) with different oxygen-containing functional groups of CNTs, which plays an important role for the potential application of CNTs in the preconcentration, removal, and separation of trivalent lanthanides and actinides in environmental pollution cleanup.

  7. A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France.

    PubMed

    Alt, Volker; Donell, Simon T; Chhabra, Amit; Bentley, Anthony; Eicher, Alexander; Schnettler, Reinhard

    2009-12-01

    The purpose of this study was to determine the cost savings from a societal perspective for recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in grade III A and B open tibial fractures treated with a locked intramedullary nail and soft-tissue management in the UK, Germany, and France. Health care system costs (direct health care costs) and costs for productivity losses (indirect health care costs) were calculated using the raw data from the Bone Morphogenetic Protein Evaluation Group in Surgery for Tibial Trauma "BESTT study". Return-to-work time for estimation of productivity losses was assumed to correspond with the time of fracture healing. For calculation of secondary interventions costs and productivity losses the respective 2007/2008 national tariffs for surgical procedures and average national wages for the UK, Germany, and France were used. For a 1 year perspective, overall treatment costs per patient after the initial surgery of the control vs. the rhBMP-2 group were 44,757 euros vs. 36,847 euros for the UK, 50,197 euros vs. 40,927 euros for Germany and 48,766 euros vs. 39,474 euros for France in favour of rhBMP-2 with overall savings overall savings per case of rhBMP-2 treatment of 7911 euros for the UK, 9270 euros for Germany, and 9291 euros for France which was mainly due to reduced productivity losses by significant faster fracture healing in the rhBMP-2 group (p=0.01). These savings largely offset the upfront price of rhBMP-2 of 2266 euros (1790 pounds) in the UK, euros 2970 in Germany, and 2950 euros in France. Total net savings can be estimated to be 9.6 million euros for the UK, 14.5 million euros for Germany, and 11.4 million euros for France. The results depend on the methodology used particularly for calculation of productivity losses and return-to-work time which was assumed to correspond with fracture healing time. In summary, despite the apparent high direct cost of rhBMP-2 in grade III A and B open tibial fractures, at a national

  8. Open and Distance Learning: Case Studies from Industry and Education. Open and Distance Learning Series.

    ERIC Educational Resources Information Center

    Brown, Stephen C., Ed.

    This book contains 14 case studies, written by those involved in the teaching and training initiatives, that illustrate the use of open and distance learning strategies. The case studies, drawn from many parts of the world (but mostly British based), feature efforts in large and small companies in a variety of industries. The first part of the…

  9. Open and Distance Learning: Case Studies from Industry and Education. Open and Distance Learning Series.

    ERIC Educational Resources Information Center

    Brown, Stephen C., Ed.

    This book contains 14 case studies, written by those involved in the teaching and training initiatives, that illustrate the use of open and distance learning strategies. The case studies, drawn from many parts of the world (but mostly British based), feature efforts in large and small companies in a variety of industries. The first part of the…

  10. Opening a New Catholic School: A Series of Case Studies.

    ERIC Educational Resources Information Center

    Kealey, Robert J., Ed.

    During the last 10 years, almost 200 new Catholic schools have opened across the United States. This booklet presents nine case studies that provide ideas about how to open new Catholic schools. The schools include: (1) Diocese of Arlington, Virginia; (2) St. John Neuman Regional Catholic School, Archdiocese of Atlanta, Georgia; (3) Charlotte…

  11. A Case Study of a New Scottish Open Plan School.

    ERIC Educational Resources Information Center

    Hamilton, David

    This report, representing a 12-month case study of a new Scottish primary school, draws together educational issues concerning problems and possibilities of open-plan schooling by locating them in the day-to-day work of a particular open-plan school. During 70 days of field work, the researcher spent time observing classes, interviewing parents,…

  12. Open-Source Data and the Study of Homicide.

    PubMed

    Parkin, William S; Gruenewald, Jeff

    2015-07-20

    To date, no discussion has taken place in the social sciences as to the appropriateness of using open-source data to augment, or replace, official data sources in homicide research. The purpose of this article is to examine whether open-source data have the potential to be used as a valid and reliable data source in testing theory and studying homicide. Official and open-source homicide data were collected as a case study in a single jurisdiction over a 1-year period. The data sets were compared to determine whether open-sources could recreate the population of homicides and variable responses collected in official data. Open-source data were able to replicate the population of homicides identified in the official data. Also, for every variable measured, the open-sources captured as much, or more, of the information presented in the official data. Also, variables not available in official data, but potentially useful for testing theory, were identified in open-sources. The results of the case study show that open-source data are potentially as effective as official data in identifying individual- and situational-level characteristics, provide access to variables not found in official homicide data, and offer geographic data that can be used to link macro-level characteristics to homicide events. © The Author(s) 2015.

  13. External Fixation combined with Limited Internal Fixation versus Open Reduction Internal Fixation for Treating Ruedi-Allgower Type III Pilon Fractures

    PubMed Central

    Guo, Yongzhi; Tong, Liangyong; Li, Shaoguang; Liu, Zhi

    2015-01-01

    Background The optimal treatment of type III pilon fractures remains controversial. Hence, we performed this study to investigate whether open reduction and internal fixation (ORIF) is superior to external fixations combined with limited internal fixations (EFLIF). Material/Methods From January 2012 to October 2013, a total of 78 patients were included. Twenty-six patients underwent EFLIF and 52 patients underwent ORIF. All subjects were followed up at 1, 3, 6, and 12 months postoperatively. All outcomes and complications were recorded. Results No statistical differences were observed in Mazur score or ROM between the 2 groups. There were significant differences between the 2 groups in hospital stay (P<0.001), reduction results (P=0.019), screw loosening (P=0.025), and traumatic arthritis (P=0.037). Conclusions Similar functional outcomes were achieved in EFLIF and ORIF groups. Due to several limitations of this study, a well-designed randomized controlled trial involving more patients and long-term follow-up is needed to find an optimal treatment protocol. PMID:26050786

  14. Selectivity enhancement of Arsenazo(III) reagent towards heavier lanthanides using polyaminocarboxylic acids: A spectrophotometric study

    NASA Astrophysics Data System (ADS)

    Matharu, Komal; Mittal, Susheel K.; Ashok Kumar, S. K.; Sahoo, Suban K.

    2015-06-01

    A new study has been conducted to quantify lanthanide(III) ions using Arsenazo III-polyaminocarboxylic acid (PACA) system. The study disclosed two different analytically important information: (i) λmax of lanthanide-Arsenazo III complexes for lighter lanthanides like Ce(III) and Nd(III) did not shift from its original position on addition of PACA and (ii) for heavier lanthanides like Dy(III), Tm(III) and Lu(III) a new λmax at 538 nm was observed, while wavelengths at 610 nm and 654 nm were disappeared in presence of ethylenediaminetertracetic acid (EDTA) and trans-1,2-Diaminocyclohexane-N,N,N‧,N‧-tetraacetic acid (DCTA), further the intensity of peak decreased with increase in lanthanide(III) ion concentration. Effect of ethylene glycol-bis(2-aminoethylether)-N,N,N‧,N‧-tetraacetic acid (EGTA) and N-(2-hydroxyethyl) ethylenediamine-N,N‧,N‧-triacetic acid (EDTA-OH) on Arsenzo(III)-Ln(III) complex is very weak and there is no analytically importance of such interaction. Moreover, this work confirms that Nd(III) and heavy lanthanides can be successfully determined with high accuracy in the working range of concentration of these metal ions.

  15. Gas-filled hohlraum study on Shenguang-III prototype

    NASA Astrophysics Data System (ADS)

    Yang, Dong; Li, Sanwei; Li, Zhichao; Yi, Rongqing; Guo, Liang; Jiang, Xiaohua; Liu, Shenye; Yang, Jiamin; Jiang, Shaoen; Ding, Yongkun; Hao, Liang; Zhang, Huasen; Zhao, Yiqing; Zou, Shiyang; Huo, Wenyi; Li, Xin

    2015-11-01

    Experimental studies on gas-filled hohlraum were performed extensively in recent years on Shenguang-III prototype laser facility. These experiments employed Au hohlraums within C5H12 gas fill heated by smoothing beams. In the first round of experiments, although the low-Z gas fill impeded the blow-off plasma ablated from hohlraum wall, the x-ray flux from the LEH decreased dramatically compared with the vacuum hohlraum. Further analysis of several ways of energy deposition including heating the gas-fill, extra scattered light and ablating the LEH membrane, revealed that too much laser energy were wasted in exploding the LEH membrane if we use a 1 ns square pulse. After we introduced a low power prepulse to intentionally exploding the membrane, the behavior of the x-ray flux from the gas-filled hohlraum is identical with the vacuum hohlraum. In subsequent studies, the motion of x-ray spot and corona plasma has also been studied using the gas-filled hohlraum. We obtained high quality data of the gas/wall interface and the boundary of the ablated wall near the LEH. The result agrees with that in simulation. However, there is a discrepancy between the experiment and the simulation in the spatial feature of the ablated wall near the LEH extracted from M-band x-ray image.

  16. Guidance for Identifying, Selecting and Evaluating Open Literature Studies

    EPA Pesticide Factsheets

    This guidance for Office of Pesticide Program staff will assist in their evaluation of open literature studies of pesticides. It also describes how we identify, select, and ensure that data we use in risk assessments is of sufficient scientific quality.

  17. Four open mammillary and catenary compartment models for pharmacokinetics studies.

    PubMed

    de Biasi, J

    1989-11-01

    A mathematical method is proposed to solve a fourth degree equation which gives the eigenvalues of the matrix connected with a four open compartment model used in pharmacokinetic studies. As examples, the method is applied to mammillary and catenary models.

  18. Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial.

    PubMed

    Taieb, Julien; Tabernero, Josep; Mini, Enrico; Subtil, Fabien; Folprecht, Gunnar; Van Laethem, Jean-Luc; Thaler, Josef; Bridgewater, John; Petersen, Lone Nørgård; Blons, Hélène; Collette, Laurence; Van Cutsem, Eric; Rougier, Philippe; Salazar, Ramon; Bedenne, Laurent; Emile, Jean-François; Laurent-Puig, Pierre; Lepage, Come

    2014-07-01

    Since the 1990s, fluorouracil-based adjuvant chemotherapy has significantly reduced the risk of tumour recurrence in patients with stage III colon cancer. We aimed to assess whether the addition of cetuximab to standard adjuvant oxaliplatin, fluorouracil, and leucovorin chemotherapy (FOLFOX4) in patients with stage III colon cancer improved disease-free survival (DFS). For this open-label, randomised phase 3 study done in nine European countries, we enrolled patients through an interactive voice response system to the central randomisation centre, with a central stratified permuted block randomisation procedure. We randomly assigned patients with resected (R0) stage III disease (1:1) to receive 12 cycles of FOLFOX4 twice a week with or without cetuximab. Patients were stratified by N-status (N1 vs N2), T-status (T1-3 vs T4), and obstruction or perforation status (no obstruction and no perforation vs obstruction or perforation or both). A protocol amendment (applied in June, 2008, after 2096 patients had been randomly assigned to treatment-restricted enrolment to patients with tumours wild-type at codons 12 and 13 in exon 2 of the KRAS gene (KRAS exon 2 wild-type). The primary endpoint was DFS. Analysis was intention to treat in all patients with KRAS exon 2 wild-type tumours. The study is registered at EudraCT, number 2005-003463-23. Between Dec 22, 2005, and Nov 5, 2009, 2559 patients from 340 sites in Europe were randomly assigned. Of these patients, 1602 had KRAS exon 2 wild-type tumours (intention-to-treat population), 791 in the FOLFOX4 plus cetuximab group and 811 in the FOLFOX4 group. Median follow-up was 3·3 years (IQR 3·2-3·4). In the experimental and control groups, DFS was similar in the intention-to-treat population (hazard ratio [HR] 1·05; 95% CI 0·85-1·29; p=0·66), and in patients with KRAS exon 2/BRAF wild-type (n=984, HR 0·99; 95% CI 0·76-1·28) or KRAS exon 2-mutated tumours (n=742, HR 1·06; 95% CI 0·82-1·37). We noted heterogeneous

  19. Lubrication studies of some type III deep eutectic solvents (DESs)

    NASA Astrophysics Data System (ADS)

    Ahmed, Essa. I.; Abbott, Andrew. P.; Ryder, Karl S.

    2017-09-01

    It has previously been shown that eutectic mixtures of quaternary ammonium salts and hydrogen bond donors form liquids with properties similar to ionic liquids [1; 2]. These so-called deep eutectic solvents (DESs) have been shown to have physical properties which would make them useful as base lubricants. The base lubricant needs to show specific properties, including high viscosity index (VI), low friction coefficient (μ), low pour point and corrosivity. To determine the applicability of DESs as base lubricants, physical properties, corrosion and lubrication properties for four type III DESs have been studied and the results have been compared with mineral base oil. The data show that the lubrication properties of DESs are superior to mineral base oil for short distances. All DESs assessed here have higher VI (191, 147, 121 for Ethaline, Glyceline and Reline respectively compared with 100 for mineral base oil), lower pour points than mineral base oil and most of the liquids studied have shown very low corrosion rates (< 3 µm year-1 for mild steel).

  20. Aqueous speciation studies of europium(III) phosphotungstate.

    PubMed

    Zhang, Cheng; Howell, Robertha C; Scotland, Kymora B; Perez, Frances G; Todaro, Louis; Francesconi, Lynn C

    2004-11-29

    The incorporation of lanthanide ions into polyoxometalates may be a unique approach to generate new luminescent, magnetic, and catalytic functional materials. To realize these new applications of lanthanide polyoxometalates, it is imperative to understand the solution speciation chemistry and its impact on solid-state materials. In this study we find that the aqueous speciation of europium(III) and the trivacant polyoxometalate, PW9O34 9-, is a function of pH, countercation, and stoichiometry. For example, at low pH, the lacunary (PW11O39)7- predominates and the 1:1 Eu(PW11O39)4-, 2, forms. As the pH is increased, the 1:2 complex, Eu(PW11O39)2 11- species, 3, and (NH4)22[(Eu2PW10O38)4(W3O8(H2O)2(OH)4].44H2O, a Eu8 hydroxo/oxo cluster, 1, form. Countercations modulate this effect; large countercations, such as K+ and Cs+, promote the formation of species 3 and 1. Addition of Al(III) as a counterion results in low pH and formation of [Eu(H2O)3(alpha-2-P2W17O61)]2, 4, with Al(III) counterions bound to terminal W-O bonds. The four species observed in these speciation studies have been isolated, crystallized, and characterized by X-ray crystallography, solution multinuclear NMR spectroscopy, and other appropriate tech-niques. These species are 1, (NH4)22[(Eu2PW10O38)4(W3O8(H2O)2(OH)4].44H2O (P; a=20.2000(0), b=22.6951(6), c=25.3200(7) A; alpha=65.6760(10), beta=88.5240(10), gamma=86.0369(10) degrees; V=10550.0(5) A3; Z=2), 2, Al(H3O)[Eu(H2O)2PW11O34].20H2O (P, a=11.4280(23), b=11.5930(23), c=19.754(4) A; alpha=103.66(3), beta=95.29(3), gamma=102.31(3) degrees; V =2456.4(9) A3; Z=2), 3, Cs11Eu(PW11O34)2.28H2O (P; a=12.8663(14), b=19.8235(22), c=21.7060(23) A; alpha=114.57(0), beta=91.86(0), gamma=102.91(0) degrees ; V=4858.3(9) A3; Z=2), 4, Al2(H3O)8[Eu(H2O)3(alpha-2-P2W17O61)]2.29H2O (P; a=12.649(6), b=16.230(8), c=21.518(9) A; alpha=111.223(16), beta=94.182(18), gamma=107.581(17) degrees ; V=3842(3) A3; Z=1).

  1. Photoluminescence studies on the complexation of Eu(III) and Tb(III) with acetohydroxamic acid (AHA) in nitrate medium

    NASA Astrophysics Data System (ADS)

    Pathak, P. N.; Mohapatra, M.; Godbole, S. V.

    2013-11-01

    UREX process has been proposed for selective extraction of U(VI) and Tc(VII) from nitric acid medium (∼1 M HNO3) using tri-n-butyl phosphate (TBP) as extractant and retaining Pu, Np and fission products in the aqueous phase. The feasibility of the use of luminescence spectroscopy as a technique to understand the complexation of trivalent f-elements cations viz. Eu(III) and Tb(III) with acetohydroxamic acid (AHA) in nitric acid medium has been examined. The luminescence lifetimes for the 1 × 10-3 M Eu(III) and AHA complex system decreased with increased AHA concentration from 116 ± 0.2 μs (no AHA) to 1.6 ± 0.1 μs (0.1 M AHA) which was attributed to dynamic quenching. The corrected fluorescence intensities were used to calculate the stability constant (log K) for the formation of 1:1 Eu3+-AHA complex as 1.42 ± 0.64 under the conditions of this study. By contrast, the Tb(III)-AHA system at pH 3 (HNO3) did not show any significant variation in the life times of the excited state (364 ± 9 μs) suggesting the absence of dynamic quenching. The spectral changes in Tb(III)-AHA system showed the formation of 1:1 complex (log K: 1.72 ± 0.21). These studies suggest that the extent of AHA complexation with the rare earth elements will be insignificant as compared to tetravalent metal ions Pu(IV) and Np(IV) under UREX process conditions.

  2. Studies on the sorption of praseodymium (III), holmium (III) and cobalt (II) from nitrate medium using TVEX-PHOR resin.

    PubMed

    El-Dessouky, S I; El-Sofany, E A; Daoud, J A

    2007-05-08

    The use of TVEX-PHOR resin for the sorption of praseodymium (III), holmium (III) and cobalt (II) from nitrate medium was carried out using batch and column techniques. Various parameters affecting the uptake of these metal ions such as v/m ratio, pH and the metal ion concentration were separately studied. Effect of temperature on the equilibrium distribution values has been studied to evaluate the changes in standard thermodynamic quantities. Experimental results of the investigated metal ions were found to fit to Freundlich isotherm model over the entire studied concentration range. Selectivity sequence of the resin for these metals is Ho>Pr>Co. The recovery of the investigated metals from the loaded resin is preformed with 0.1M sulphuric acid.

  3. Hydrologic studies in wells open through large intervals

    SciTech Connect

    Not Available

    1992-01-01

    This report describes and summarizes activities, data, and preliminary data interpretation from the INEL Oversight Program R D-1 project titled Hydrologic Studies In Wells Open Through Large Intervals.'' The project is designed to use a straddle-packer system to isolate, hydraulically test, and sample specific intervals of monitoring wells that are open (uncased, unscreened) over large intervals of the Snake River Plain aquifer. The objectives of the project are to determine and compare vertical variations in water quality and aquifer properties that have previously only been determined in an integrated fashion over the entire thickness of the open interval of the observation wells.

  4. Biology of biomechanics: Finite element analysis of a statically determinate system to rotate the occlusal plane for correction of a skeletal Class III open-bite malocclusion.

    PubMed

    Roberts, W Eugene; Viecilli, Rodrigo F; Chang, Chris; Katona, Thomas R; Paydar, Nasser H

    2015-12-01

    In the absence of adequate animal or in-vitro models, the biomechanics of human malocclusion must be studied indirectly. Finite element analysis (FEA) is emerging as a clinical technology to assist in diagnosis, treatment planning, and retrospective analysis. The hypothesis tested is that instantaneous FEA can retrospectively simulate long-term mandibular arch retraction and occlusal plane rotation for the correction of a skeletal Class III malocclusion. Seventeen published case reports were selected of patients treated with statically determinate mechanics using posterior mandible or infrazygomatic crest bone screw anchorage to retract the mandibular arch. Two-dimensional measurements were made for incisor and molar movements, mandibular arch rotation, and retraction relative to the maxillary arch. A patient with cone-beam computed tomography imaging was selected for a retrospective FEA. The mean age for the sample was 23.3 ± 3.3 years; there were 7 men and 10 women. Mean incisor movements were 3.35 ± 1.55 mm of retraction and 2.18 ± 2.51 mm of extrusion. Corresponding molar movements were retractions of 4.85 ± 1.78 mm and intrusions of 0.85 ± 2.22 mm. Retraction of the mandibular arch relative to the maxillary arch was 4.88 ± 1.41 mm. Mean posterior rotation of the mandibular arch was -5.76° ± 4.77° (counterclockwise). The mean treatment time (n = 16) was 36.2 ± 15.3 months. Bone screws in the posterior mandibular region were more efficient for intruding molars and decreasing the vertical dimension of the occlusion to close an open bite. The full-cusp, skeletal Class III patient selected for FEA was treated to an American Board of Orthodontics Cast-Radiograph Evaluation score of 24 points in about 36 months by en-masse retraction and posterior rotation of the mandibular arch: the bilateral load on the mandibular segment was about 200 cN. The mandibular arch was retracted by about 5 mm, posterior rotation was about 16.5°, and molar intrusion was about 3

  5. Reactor physics studies in the GCFR Phase III critical assembly

    SciTech Connect

    Morman, J A

    1980-03-01

    The third phase of the gas cooled fast reactor (GCFR) program, ZPR-9 Assembly 30, is based on a multi-zoned core of PuO/sub 2/-UO/sub 2/ with radial and axial blankets of UO/sub 2/. Studies performed in this assembly will be compared to the previous phases of the GCFR program and will help to define parameters in this power-flattened demonstration plant-type core. Measurements in the Phase III program included small sample reactivity worths of various materials, central reaction rates and reaction rate distributions, absorption-to-fission ratios and the central point conversion ratio and the worth of steam entry into a small central zone. The reactivity change associated with the construction of a central pin zone in the core and axial blanket was measured. Reaction rate and steam entry measurements were repeated in the pin environment. Standard analysis methods using ENDF/B-IV data are described and the results are compared to measurements performed during the program.

  6. A computational study of open-chain epothilone analogue

    NASA Astrophysics Data System (ADS)

    Kamel, Karol; Rusinska-Roszak, Danuta

    Molecular mechanics (MM/Ambers) calculations were applied to probe the conformational profile of open-chain epothilone analogue [Org Lett 2006, 8, 685], cytotoxic against some cell lines. Geometries of the most stable conformers were optimized at DFT level using the B3LYP functional and then compared to known both experimental and virtual conformers of epothilone. One of the most stable structures is III (1.47 kcal/mol above global minimum) which represents high similarity to the appropriate fragment of the Taylor's model of epothilone A, but two other conformers: XIV and XX, although they have almost the same conformation as the mother structure, are very unstable (6.7 and 12.4 kcal/mol above the global minimum).0

  7. Perturbation of Maize Phenylpropanoid Metabolism by an AvrE Family Type III Effector from Pantoea stewartii1[OPEN

    PubMed Central

    Asselin, Jo Ann E.; Lin, Jinshan; Perez-Quintero, Alvaro L.; Gentzel, Irene; Majerczak, Doris; Opiyo, Stephen O.; Zhao, Wanying; Paek, Seung-Mann; Kim, Min Gab; Coplin, David L.; Blakeslee, Joshua J.; Mackey, David

    2015-01-01

    AvrE family type III effector proteins share the ability to suppress host defenses, induce disease-associated cell death, and promote bacterial growth. However, despite widespread contributions to numerous bacterial diseases in agriculturally important plants, the mode of action of these effectors remains largely unknown. WtsE is an AvrE family member required for the ability of Pantoea stewartii ssp. stewartii (Pnss) to proliferate efficiently and cause wilt and leaf blight symptoms in maize (Zea mays) plants. Notably, when WtsE is delivered by a heterologous system into the leaf cells of susceptible maize seedlings, it alone produces water-soaked disease symptoms reminiscent of those produced by Pnss. Thus, WtsE is a pathogenicity and virulence factor in maize, and an Escherichia coli heterologous delivery system can be used to study the activity of WtsE in isolation from other factors produced by Pnss. Transcriptional profiling of maize revealed the effects of WtsE, including induction of genes involved in secondary metabolism and suppression of genes involved in photosynthesis. Targeted metabolite quantification revealed that WtsE perturbs maize metabolism, including the induction of coumaroyl tyramine. The ability of mutant WtsE derivatives to elicit transcriptional and metabolic changes in susceptible maize seedlings correlated with their ability to promote disease. Furthermore, chemical inhibitors that block metabolic flux into the phenylpropanoid pathways targeted by WtsE also disrupted the pathogenicity and virulence activity of WtsE. While numerous metabolites produced downstream of the shikimate pathway are known to promote plant defense, our results indicate that misregulated induction of phenylpropanoid metabolism also can be used to promote pathogen virulence. PMID:25635112

  8. OpenSimulator Interoperability with DRDC Simulation Tools: Compatibility Study

    DTIC Science & Technology

    2014-09-01

    OpenSimulator has been designed to operate and interface with users, how it incorporates terrain models, and what its capabilities are with regard to...ship design , and SmartPlant 3D for plant design , are two CAD programs used or intended to be used by DND. The 3D CAD models created by these programs...OpenSimulator Interoperability with DRDC Simulation Tools Compatibility Study Mark Swartz Evan Harris CAE Inc. - Integrated

  9. Plasma opening switch studies of an applied Bz ion diode

    NASA Astrophysics Data System (ADS)

    Struckman, C. K.; Kusse, B. R.; Meyerhofer, D. D.; Rondeau, G.

    1989-05-01

    The light ion accelerator (1.5 MV, 4 ohms) at Cornell University is being used to study the characteristics of an applied Bz, or 'barrel', diode. The results of a series of experiments utilizing a plasma opening switch are reported. With a magnetically insulated ion diode load, the peak diode voltage increase from 1.5 to 1.8 MV and the ion power increased from 50 to 80 GW when a plasma opening switch was used.

  10. Evaluation of the MOZAIC Capacitive Hygrometer during the airborne field study CIRRUS-III

    NASA Astrophysics Data System (ADS)

    Neis, P.; Smit, H. G. J.; Krämer, M.; Spelten, N.; Petzold, A.

    2015-03-01

    The MOZAIC Capacitive Hygrometer (MCH) is usually operated aboard passenger aircraft in the framework of MOZAIC (Measurement of Ozone by Airbus In-Service Aircraft) for measuring atmospheric relative humidity (RH). In order to evaluate the performance of the MCH, the instrument was operated aboard a Learjet 35A research aircraft as part of the CIRRUS-III field study together with a closed-cell Lyman-α fluorescence hygrometer (Fast in situ Stratospheric Hygrometer, or FISH) and an open-path tunable diode laser system (Open-path Jülich Stratospheric TDL ExpeRiment, or OJSTER) for water vapour measurement. After reducing the CIRRUS-III data set to data corresponding to MOZAIC aircraft operation conditions, the 1 Hz RH data cross correlation between the MCH and reference instruments FISH (clear sky) and OJSTER (in-cirrus) yielded a remarkably good agreement of R2 = 0.92 and slope m = 1.02 and provided a MCH uncertainty of 5% RH. Probability distribution functions of RH deduced from the MCH and reference instruments agreed well between 10 and 70% RH with respect to liquid water in the ambient temperature range of ca. -70 to -40 °C. The use of MCH data is limited to sensor temperatures above the calibration limit of Tsensor = -40 °C (corresponds to ambient temperature of Tambient = -70 °C at typical cruising speed of long-haul passenger aircraft). Good performance of the MCH for clear sky as well as for in-cirrus conditions demonstrated the sensor robustness also for operation inside ice clouds.

  11. A Descriptive Study of Open Fractures Contaminated by Seawater: Infection, Pathogens, and Antibiotic Resistance.

    PubMed

    Zhu, Hongyi; Li, Xingwei; Zheng, Xianyou

    2017-01-01

    Aims. In this work, the main objectives were to investigate the clinical characteristics and bacterial spectrum present in open fractures contaminated by seawater. Methods. We conducted a retrospective cohort study and included all patients with open fractures from 1st January, 2012, to 31st December, 2015, in our hospital. Patients were grouped based on the presence of seawater contamination in wounds. We compared the infection rate, bacterial spectrum, and antibiotic resistance between the two groups. Results. We totally included 1337 cases of open fracture. Wounds from 107 cases (8.0%) were contaminated by seawater. The wound infection rate of seawater-contaminated group was significantly higher in patients with Gustilo-Anderson Type II and Type III open fractures. The bacterial spectrum from seawater-contaminated wounds was remarkably different from that of the remaining. Antibiotic sensitivity tests revealed that more than 90% of infecting pathogens in seawater-contaminated wounds were sensitive to levofloxacin and ciprofloxacin. Conclusion. Cephalosporin in combination with quinolone was recommended in the early-stage management of open fractures contaminated by seawater.

  12. A Descriptive Study of Open Fractures Contaminated by Seawater: Infection, Pathogens, and Antibiotic Resistance

    PubMed Central

    Zhu, Hongyi

    2017-01-01

    Aims. In this work, the main objectives were to investigate the clinical characteristics and bacterial spectrum present in open fractures contaminated by seawater. Methods. We conducted a retrospective cohort study and included all patients with open fractures from 1st January, 2012, to 31st December, 2015, in our hospital. Patients were grouped based on the presence of seawater contamination in wounds. We compared the infection rate, bacterial spectrum, and antibiotic resistance between the two groups. Results. We totally included 1337 cases of open fracture. Wounds from 107 cases (8.0%) were contaminated by seawater. The wound infection rate of seawater-contaminated group was significantly higher in patients with Gustilo-Anderson Type II and Type III open fractures. The bacterial spectrum from seawater-contaminated wounds was remarkably different from that of the remaining. Antibiotic sensitivity tests revealed that more than 90% of infecting pathogens in seawater-contaminated wounds were sensitive to levofloxacin and ciprofloxacin. Conclusion. Cephalosporin in combination with quinolone was recommended in the early-stage management of open fractures contaminated by seawater. PMID:28303249

  13. A swirl generator case study for OpenFOAM

    NASA Astrophysics Data System (ADS)

    Petit, O.; Bosioc, A. I.; Nilsson, H.; Muntean, S.; Susan-Resiga, R. F.

    2010-08-01

    This work presents numerical results, using OpenFOAM, of the flow in the swirl flow generator test rig developed at Politehnica University of Timisoara, Romania. The work shows results computed by solving the unsteady Reynolds Averaged Navier Stokes equations. The unsteady method couples the rotating and stationary parts using a sliding grid interface based on a GGI formulation. Turbulence is modeled using the standard k-epsilon model, and block structured wall function ICEM-Hexa meshes are used. The numerical results are validated against experimental LDV results, and against designed velocity profiles. The investigation shows that OpenFOAM gives results that are comparable to the experimental and designed profiles. This case study was presented at the 5th OpenFOAM Workshop, held in Gothenburg, Sweden, as a tutorial on how to treat turbomachinery applications in OpenFOAM.

  14. Laparoscopic Appendectomy Versus Open Appendectomy: A Single Institution Study

    PubMed Central

    Anderson, David G.

    1997-01-01

    Purpose: The purpose of this study was to compare the safety and efficacy of laparoscopic appendectomy versus open appendectomy at Baptist Hospital in Miami, Florida. Methods: A retrospective review was performed on all appendectomies performed at Baptist Hospital from October 1, 1994 to September 30, 1995. There were a total of 244 cases; 137 open appendectomies and 107 laparoscopic appendectomies. The cases were reviewed with regard to pathology, operating time, length of hospital stay and complications. Results: The pathologic findings at surgery were similar for the two groups. Concomitant pathology was more likely to be found laparoscopically than in open surgery. There was a greater percentage of ruptured appendices in surgery done via the open method. Operative time was slightly longer, but complications were less in the laparoscopic group. Length of stay was lower in the laparoscopic appendectomy group. Conclusions: Although very similar, our method of appendectomy favors the laparoscopic technique. PMID:9876696

  15. Does the Zone of Injury in Combat-Related Type III Open Tibia Fractures Preclude the Use of Local Soft Tissue Coverage?

    DTIC Science & Technology

    2010-11-01

    procedure. J Bone Joint Surg Am. 2001;83:239 246. 6. Burgess AR, Poka A, Brumback RJ , et al. Management of open grade III tibial fractures. Orthop Clin...extremities with failed free flaps: a single institution’s experience over 25 years. Ann Plast Surg. 2007;59:18 21. 19. Fix RJ , Vasconez LO...of lower extremity defects: anatomic considerations. Surg Clin North Am. 1974;54:1337 1354. 22. Shepherd LE, Costigan WM, Gardocki RJ , et al. Local or

  16. STUDIES ON NATURAL IMMUNITY TO PNEUMOCOCCUS TYPE III

    PubMed Central

    Shaffer, Morris F.; Enders, John F.; Wu, Chao-Jen

    1936-01-01

    The results which have been presented show that under the conditions of artificial cultivation at 37°C. definite differences exist between two smooth strains of Pneumococcus Type III both of which are highly virulent for mice by the intraperitoneal route, but which may be sharply distinguished in their virulence for rabbits. These differences consist in the size of the fully developed intact capsule and the interval of time required for its loss. The somewhat smaller capsule of the avirulent strain, well formed and easily demonstrable during the early period of growth, diminishes quickly, while the large capsule of the strain virulent for rabbits is retained for a considerably longer period. Closely correlated with the time at which this reduction of capsule occurs is the appearance of changes in the surface properties of the bacteria which are revealed by a shifting of the range of acid agglutination, susceptibility to clumping in anti-R serum and ingestion by normal adult human polymorphonuclear leucocytes and serum. Since it has been shown that these alterations as growth continues, result in a loss of characteristics which distinguish the strictly type specific, fully capsulated pneumococcus and ultimately lead to a state temporarily approximating that of the completely avirulent R form, and since under the experimental conditions they are inaugurated sooner, advance more rapidly and are more complete in the rabbit avirulent organism, we believe that they may partly account for difference in rabbit virulence of the two strains. In the following paper an attempt has therefore been made to correlate this behavior in vitro with the events attendant upon inoculation into the animal body. The studies of Clark and Ruehl (16), Henrici (17), Bayne-Jones and Adolph (18) and others have demonstrated a marked increase in the size of the bacterial cell associated with the early phases of growth. These authors have dealt chiefly with noncapsulated rod forms and even Clark

  17. Studies in Natural Illumination in Schoolrooms. Part III

    DTIC Science & Technology

    1929-11-01

    PI"C HEALTH BULLIN No. 188 STUDIESJIN ATURA ILUMINATION IN SCHOOLROOMSA f1-~7~PART III 20 U. 0 49990809 433 UngimED STATES ý-REASURY DE~PART1WENT... ilumination ratio of desk No. 14 for each month and hour of observation ---------------------------------------------- 55 29. Mean illumination ratio of desk

  18. High Voltage, Low Inductance Hydrogen Thyratron Study Program, Phase III.

    DTIC Science & Technology

    1981-12-01

    results and supporting information that bear on the progress of the Program as a whole. The Government’s Contract Monitor for Phase III was Mr. William ...ST ATTN: DRDEL-LL; -SB; -AP (IN TURN) I DRSEL-MA-MP 2800 Powder Mill Road 2 DRSEL-PA Adelphi, MD 20783 001 CINDAS 001 Cdr, ERADCOM Purdue Industrial

  19. EXPERIMENTAL RESULTS OF THE NEPHELINE PHASE III STUDY

    SciTech Connect

    Fox, K.; Edwards, T.

    2009-11-09

    This study is the third phase in a series of experiments designed to reduce conservatism in the model that predicts the formation of nepheline, a crystalline phase that can reduce the durability of high level waste glass. A Phase I study developed a series of glass compositions that were very durable while their nepheline discriminator values were well below the current nepheline discriminator limit of 0.62, where nepheline is predicted to crystallize upon slow cooling. A Phase II study selected glass compositions to identify any linear effects of composition on nepheline crystallization and that were restricted to regions that fell within the validation ranges of the Defense Waste Processing Facility (DWPF) Product Composition Control System (PCCS) models. However, it was not possible to identify any linear effects of composition on chemical durability performance for this set of study glasses. The results of the Phase II study alone were not sufficient to recommend modification of the current nepheline discriminator. It was recommended that the next series of experiments continue to focus not only on compositional regions where the PCCS models are considered applicable (i.e., the model validation ranges), but also be restricted to compositional regions where the only constraint limiting processing is the current nepheline discriminator. Two methods were used in selecting glasses for this Phase III nepheline study. The first was based on the relationship of the current nepheline discriminator model to the other DWPF PCCS models, and the second was based on theory of crystallization in mineral and glass melts. A series of 29 test glass compositions was selected for this study using a combination of the two approaches. The glasses were fabricated and characterized in the laboratory. After reviewing the data, the study glasses generally met the target compositions with little issue. Product Consistency Test results correlated well with the crystallization analyses in

  20. Open-label extension studies: do they provide meaningful information on the safety of new drugs?

    PubMed

    Day, Richard O; Williams, Kenneth M

    2007-01-01

    The number of open-label extension studies being performed has increased enormously in recent years. Often it is difficult to differentiate between these extension studies and the double-blind, controlled studies that preceded them. If undertaken primarily to gather more patient-years of exposure to the new drug in order to understand and gain confidence in its safety profile, open-label extension studies can play a useful and legitimate role in drug development and therapeutics. However, this can only occur if the open-label extension study is designed, executed, analysed and reported competently. Most of the value accrued in open-label extension studies is gained from a refinement in the perception of the expected incidence of adverse effects that have most likely already been identified as part of the preclinical and clinical trial programme. We still have to rely heavily on post-marketing safety surveillance systems to alert us to type B (unpredictable) adverse reactions because open-label extension studies are unlikely to provide useful information about these types of often serious and relatively rare adverse reactions. Random allocation into test and control groups is needed to produce precise incidence data on pharmacologically expected, or type A, adverse effects. Some increased confidence about incidence rates might result from the open-label extension study; however, as these studies are essentially uncontrolled and biased, the data are not of great value. Other benefits have been proposed to be gained from open-label extension studies. These include ongoing access to an effective but otherwise unobtainable medicine by the volunteers who participated in the phase III pivotal trials. However, there are unappreciated ethical issues about the appropriateness of enrolling patients whose response to previous treatment is uncertain, largely because treatment allocation in the preceding randomised, double-blind, controlled trial has not been revealed at the

  1. Study on diesel-DME spray using open-source CFD (OpenFoam)

    NASA Astrophysics Data System (ADS)

    Fajar, Rizqon; Sugiarto, Bambang; Darsono, Dody

    2012-06-01

    In this work, a numerical study has been performed to evaluate the fuel spray of diesel, dimethyl ether (DME) and its mixture using CFD code OpenFoam. This study uses a general method, based on simulating fuel sprays injected into a constant volume vessel. Calculations results are presented as profiles of diameter (MD) and temperature of fuel droplets as function of fuel type. The results have shown that the diameter of fuel droplet decreased as the fraction of DME in the mixture is higher. Fuel properties affected the atomization and evaporation process. The SMD increased with viscosity and the evaporation rate of fuel spray increased with fuel volatility.

  2. [Laparoscopic versus open surgery for colorectal cancer. A comparative study].

    PubMed

    Arribas-Martin, Antonio; Díaz-Pizarro-Graf, José Ignacio; Muñoz-Hinojosa, Jorge Demetrio; Valdés-Castañeda, Alberto; Cruz-Ramírez, Omar; Bertrand, Martin Marie

    2014-01-01

    Laparoscopic surgery for colorectal cancer is currently accepted and widespread worldwide. However, according tol the surgical experience on this approach, surgical and short-term oncologic results may vary. Studies comparing laparoscopic vs. open surgery in our population are scarce. To determine the superiority of the laparoscopic vs. open technique for colorectal cancer surgery. This retrospective and comparative study collected data from patients operated on for colorectal cancer between 1999 and 2011 at the Angeles Lomas Hospital, Mexico. A total of 82 patients were included in this study; 47 were operated through an open approach and 35 laparoscopically. Mean operative time was significantly lower in the open approach group (p= 0.008). There were no significant difference between both techniques for intraoperative bleeding (p= 0.3980), number of lymph nodes (p= 0.27), time to initiate oral feeding (p= 0.31), hospital stay (p= 0.12), and postoperative pain (p= 0.19). Procedure-related complications rate and type were not significantly different in both groups (p= 0.44). Patients operated laparoscopically required significantly less analgesic drugs (p= 0.04) and less need for epidural postoperative analgesia (p= 0.01). Laparoscopic approach is as safe as the traditional open approach for colorectal cancer. Early oncological and surgical results confirm its suitability according to this indication.

  3. 76 FR 33398 - 60-Day Notice of Proposed Information Collection; Passport Demand Forecasting Study Phase III...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Collection: Passport Demand Forecasting Study Phase III. OMB Control Number: OMB No. 1405-0177. Type of... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 60-Day Notice of Proposed Information Collection; Passport Demand Forecasting Study Phase III, 1405-0177 ACTION...

  4. 76 FR 53704 - 30-Day Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... Notice of Proposed Information Collection: Passport Demand Forecasting Study Phase III, OMB Number 1405... of 1995. Title of Information Collection: Passport Demand Forecasting Study Phase III. OMB Control Number: OMB Number 1405-0177. Type of Request: Revision of a Currently Approved Collection. Originating...

  5. Intravenous immunoglobulin for maintenance treatment of chronic inflammatory demyelinating polyneuropathy: a multicentre, open-label, 52-week phase III trial.

    PubMed

    Kuwabara, Satoshi; Mori, Masahiro; Misawa, Sonoko; Suzuki, Miki; Nishiyama, Kazutoshi; Mutoh, Tatsuro; Doi, Shizuki; Kokubun, Norito; Kamijo, Mikiko; Yoshikawa, Hiroo; Abe, Koji; Nishida, Yoshihiko; Okada, Kazumasa; Sekiguchi, Kenji; Sakamoto, Ko; Kusunoki, Susumu; Sobue, Gen; Kaji, Ryuji

    2017-10-01

    Short-term efficacy of induction therapy with intravenous immunoglobulin (Ig) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) is well established. However, data of previous studies on maintenance therapy were limited up to 24-week treatment period. We aimed to investigate the efficacy and safety of longer-term intravenous Ig therapy for 52 weeks. This study was an open-label phase 3 clinical trial conducted in 49 Japanese tertiary centres. 49 patients with CIDP who fulfilled diagnostic criteria were included. After an induction intravenous Ig therapy (0.4 g/kg/day for five consecutive days), maintenance dose intravenous Ig (1.0 g/kg) was given every 3 weeks for up to 52 weeks. The primary outcome measures were the responder rate at week 28 and relapse rate at week 52. The response and relapse were defined with the adjusted Inflammatory Neuropathy Cause and Treatment scale. At week 28, the responder rate was 77.6% (38/49 patients; 95% CI 63% to 88%), and the 38 responders continued the maintenance therapy. At week 52, 4 of the 38 (10.5%) had a relapse (95% CI 3% to 25%). During 52 weeks, 34 (69.4%) of the 49 enrolled patients had a maintained improvement. Adverse events were reported in 94% of the patients; two patients (66-year-old and 76-year-old men with hypertension or diabetes) developed cerebral infarction (lacunar infarct with good recovery), and the other adverse effects were mild and resolved by the end of the study period. Maintenance treatment with 1.0 g/kg intravenous Ig every 3 weeks is an efficacious therapy for patients with CIDP, and approximately 70% of them had a sustained remission for 52 weeks. Thrombotic complications should be carefully monitored, particularly in elderly patients with vascular risk factors. ClinicalTrials.gov (NCT01824251). © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise

  6. Illinois Natural Heritage Conservation/Education Kit III. Special Theme: Prairie and Open Habitats Ecology and Management.

    ERIC Educational Resources Information Center

    Stone, Sally F.

    This instructional guide contains 15 activities and exercises designed to help teachers familiarize their students with prairie and open habitat resources of Illinois. Each activity or exercise is ready to be copied and given to students. Activities include: (1) making a marsh hawk model; (2) building a prairie ecosystem; (3) investigating food…

  7. Bismuth(III) trifluoromethanesulfonate catalyzed ring opening reaction of mono epoxy oleochemicals to form keto and diketo derivatives

    USDA-ARS?s Scientific Manuscript database

    Using a catalytic system, methyl oleate is transformed into long chain keto and diketo derivatives via an epoxide route. Methyl 9(10)-oxooctadecanoate and methyl 9,10-dioxooctadecanoate were made by a ring opening reaction of epoxidized methyl oleate using bismuth triflate catalyst. Lower reaction t...

  8. Resonant Raman Scattering Studies of Iii-V Semiconductor Microstructures

    NASA Astrophysics Data System (ADS)

    Delaney, Malcolm Emil

    1991-02-01

    Raman spectroscopy, an inelastic light scattering technique, explores III-V semiconductors by conveying crystal lattice structural information and by probing carrier dynamics both directly and via the electron-phonon interaction. We have examined three physical systems accentuating three aspects of Raman utility. Al_{rm x}Ga_{rm 1-x} As alloy work emphasizes electronic behavior, migration enhanced epitaxy (MEE) studies highlight structural results, and a phonon-assisted lasing project underscores electron -phonon interaction. The disorder-induced frequency difference between the dipole-forbidden and dipole-allowed longitudinal optic (LO) modes in Al_{rm x} Ga_{rm 1-x}As alloys has been investigated as a function of laser photon energy, aluminum mole fraction x, and the indirect versus direct nature of the electronic band gap. For the indirect gap alloy, the intermediate resonant state is an X-valley electron effectively localized because of its short inelastic lifetime. Raman scattering via this state is described by a calculation of the Raman susceptibility that considers the random alloy potential generated by local concentration fluctuations. MEE is a new growth technology that can order these materials in two spatial directions. In a GaSb/AlSb system we show Raman evidence of this ordering via observation of zone folded acoustic modes and compare to AlAs/GaAs results. In other work resonant Raman documents the effects on the dipole-forbidden interface mode of a periodic corrugation introduced in AlAs barrier GaAs single quantum wells. Finally, we investigate "phonon-assisted" lasing in photopumped quantum well heterostructure lasers. Resonant Raman is the natural choice to probe this system purported to have an enhanced electron-phonon interaction. For both the AlGaAs/GaAs and AlGaAs/GaAs/InGaAs structures examined, we provide evidence that indicates first order "phonon -assisted" lasing is actually renormalized band gap luminescence filtered by absorption from

  9. Open source drug discovery in practice: a case study.

    PubMed

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality research at low cost. The critical success factors appear to be clearly

  10. Open Source Drug Discovery in Practice: A Case Study

    PubMed Central

    Årdal, Christine; Røttingen, John-Arne

    2012-01-01

    Background Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. Methodology/Principal Findings A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. Conclusions/Significance Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality

  11. Los Angeles International Airport Runway Incursion Studies: Phase III--Center-Taxiway Simulation

    NASA Technical Reports Server (NTRS)

    Madson, Michael D.

    2004-01-01

    Phase III of the Los Angeles International Airport Runway Incursion Studies was conducted, under an agreement with HNTB Corporation, at the NASA Ames FutureFlight Central (FFC) facility in June 2003. The objective of the study was the evaluation of a new center-taxiway concept at LAX. This study is an extension of the Phase I and Phase II studies previously conducted at FFC. This report presents results from Phase III of the study, in which a center-taxiway concept between runways 25L and 25R was simulated and evaluated. Phase III data were compared objectively against the Baseline data. Subjective evaluations by participating LAX controllers were obtained with regard to workload, efficiency, and safety criteria. To facilitate a valid comparison between Baseline and Phase III data, the same scenarios were used for Phase III that were tested during Phases I and II. This required briefing participating controllers on differences in airport and airline operations between 2001 and today.

  12. Surgery for Type III-IV hiatal hernia: anatomical recurrence and global results after elective treatment of short oesophagus with open and minimally invasive surgery.

    PubMed

    Lugaresi, Marialuisa; Mattioli, Benedetta; Daddi, Niccolò; Di Simone, Massimo Pierluigi; Perrone, Ottorino; Mattioli, Sandro

    2016-04-01

    Type III-IV hiatal hernia (HH) is associated with a true short oesophagus in more than 50% of cases; dedicated treatment of this condition might be appropriate to reduce the recurrence rate after surgery. A case series of patients receiving surgery for Type III-IV hernia was examined for short oesophagus, and the results were analysed. From 1980 to 1994, 60 patients underwent an open surgical approach, and the position of the oesophago-gastric junction was visually localized; from 1995 to 2013, 48 patients underwent a minimally invasive approach, and the oesophago-gastric junction was objectively localized using a laparoscopic-endoscopic method. The patients underwent a timed clinical-instrumental follow-up that included symptoms assessment, barium swallow and endoscopy. The results were considered to be excellent in the absence of symptoms and oesophagitis; good, if symptoms occurred two to four times a month in the absence of oesophagitis; fair, if symptoms occurred two to four times a week in the presence of hyperaemia, oedema and/or microscopic oesophagitis; and poor, if symptoms occurred on a daily basis in the presence of any grade of endoscopic oesophagitis, HH of any size or type, or the need for antireflux medical therapy. The follow-up time was calculated from the time of surgery to the last complete follow-up. Among the open surgery patients, 78% underwent abdominal fundoplication, 10% the Belsey Mark IV procedure, 8% laparotomic Collis-Nissen fundoplication and 3% the Pearson operation. Among the minimally invasive surgery patients, 44% underwent a laparoscopic floppy Nissen procedure and 56% a left thoracoscopic Collis-laparoscopic Nissen procedure. The postoperative mortality and complication rates were 1.6% (1/60) and 15% for open surgery and 4.1% (2/48) and 12.5% for minimally invasive surgery. A total of 105 patients were followed up for a median period of 96 months. Five relapses occurred after open surgery (5/59, 8%) and two after minimally

  13. A comparative study between shielded and open coplanar waveguide discontinuities

    NASA Technical Reports Server (NTRS)

    Dib, Nihad I.; Harokopus, W. P., Jr.; Ponchak, G. E.; Katehi, L. P. B.

    1993-01-01

    A comparative study between open and shielded coplanar waveguide (CPW) discontinuities is presented. The space domain integral equation method is used to characterize several discontinuities such as the open-end CPW and CPW series stubs. Two different geometries of CPW series stubs (straight and bent stubs) are compared with respect to resonant frequency and radiation loss. In addition, the encountered radiation loss due to different CPW shunt stubs is evaluated experimentally. The notion of forced radiation simulation is presented, and the results of such a simulation are compared to the actual radiation loss obtained rigorously. It is shown that such a simulation cannot give reliable results concerning radiation loss from printed circuits.

  14. Environmental Technology Verification (ETV) Program Case Studies: Demonstrating Program Outcomes, Volume III

    EPA Science Inventory

    This booklet, ETV Program Case Studies: Demonstrating Program Outcomes, Volume III contains two case studies, addressing verified environmental technologies for decentalized wastewater treatment and converting animal waste to energy. Each case study contains a brief description ...

  15. Environmental Technology Verification (ETV) Program Case Studies: Demonstrating Program Outcomes, Volume III

    EPA Science Inventory

    This booklet, ETV Program Case Studies: Demonstrating Program Outcomes, Volume III contains two case studies, addressing verified environmental technologies for decentalized wastewater treatment and converting animal waste to energy. Each case study contains a brief description ...

  16. A Collection of Studies. Research on Syntactic Typology Volume III of III Volumes. Final Substantive Report.

    ERIC Educational Resources Information Center

    Berman, Arlene; And Others

    This final volume of a three-part report on various language research projects contains ten studies on a wide variety of language issues. The topics include "Some Aspects of Language Interference,""Contrastive Analysis of Case Marking in Polynesian Languages,""Notes on the Formation of Complex Sentences in Tunisian Arabic with Emphasis on the…

  17. Open Educational Resources: A Delphi Study of Instructional Design Quality

    ERIC Educational Resources Information Center

    Emerson, Marnice K.

    2013-01-01

    The purpose of this modified Delphi research study was to investigate instructional designers' beliefs about the instructional strategies and activities to be included in a universal framework for designing quality, self-directed, multimedia, open educational resources (OERs). With the rapid growth of availability and use of OERs by a widely…

  18. Spin-adapted open-shell time-dependent density functional theory. III. An even better and simpler formulation.

    PubMed

    Li, Zhendong; Liu, Wenjian

    2011-11-21

    The recently proposed spin-adapted time-dependent density functional theory (S-TD-DFT) [Z. Li and W. Liu, J. Chem. Phys. 133, 064106 (2010)] resolves the spin-contamination problem in describing singly excited states of high spin open-shell systems. It is an extension of the standard restricted open-shell Kohn-Sham-based TD-DFT which can only access those excited states due to singlet-coupled single excitations. It is also far superior over the unrestricted Kohn-Sham-based TD-DFT (U-TD-DFT) which suffers from severe spin contamination for those excited states due to triplet-coupled single excitations. Nonetheless, the accuracy of S-TD-DFT for high spin open-shell systems is still inferior to TD-DFT for well-behaved closed-shell systems. The reason can be traced back to the violation of the spin degeneracy conditions (SDC) by approximate exchange-correlation (XC) functionals. Noticing that spin-adapted random phase approximation (S-RPA) can indeed maintain the SDC by virtue of the Wigner-Eckart theorem, a hybrid ansatz combining the good of S-TD-DFT and S-RPA can immediately be envisaged. The resulting formalism, dubbed as X-TD-DFT, is free of spin contamination and can also be viewed as a S-RPA correction to the XC kernel of U-TD-DFT. Compared with S-TD-DFT, X-TD-DFT leads to much improved results for the low-lying excited states of, e.g., N(2)(+), yet with much reduced computational cost. Therefore, X-TD-DFT can be recommended for routine calculations of excited states of high spin open-shell systems.

  19. A spectrophotometric study of Nd(III), Sm(III) and Er(III) complexation in sulfate-bearing solutions at elevated temperatures

    NASA Astrophysics Data System (ADS)

    Migdisov, Art. A.; Williams-Jones, A. E.

    2008-11-01

    The speciation of Nd(III), Sm(III), and Er(III) in sulfate-bearing solutions has been determined spectrophotometrically at temperatures from 25 to 250 °C and a pressure of 100 bars. The data obtained earlier on the speciation of Nd in sulfate-bearing solutions ( Migdisov et al., 2006) have been re-evaluated and corrected using a more appropriate activity model and are compared with the corresponding data for Sm(III) and Er(III) and new data for Nd(III). Based on this comparison, the dominant species in the solution are interpreted to be REESO4+ and REE(SO)2-, with the latter complex increasing in importance at higher temperature. Equilibrium constants were calculated for the following reactions:

  20. The WISC-III and Raven Coloured Progressive Matrices Test: A Pilot Study of Relationships.

    ERIC Educational Resources Information Center

    Kluever, Raymond C.; And Others

    The relationship between scores on Raven's Coloured Progressive Matrices (CPM) scores and subtest scores and IQs from the Wechsler Intelligence Scale for Children-III (WISC-III) was studied for 28 children aged 6 to 11 years. Subjects had been referred to a university assessment center because they were believed to have exceptional learning…

  1. Clinical evaluation of the centrifugal pump in open heart surgery: a comparative study of different pumps.

    PubMed

    Takarabe, K; Yoshikai, M; Murayama, J; Hamada, M; Ito, T

    1997-07-01

    The centrifugal pump is now widely used in open heart surgery for its clinical benefits related to the blood elements and the coagulation system. The purpose of this study was to compare the clinical performances of and the outcomes offered by 4 types of centrifugal pumps. For each pump, we investigated the effects on the blood elements, coagulation system, complements, and immunoglobulins during open heart surgery. Four types of centrifugal pumps were used: the HPM-15 (Nikkiso Co.), the Capiox (Terumo Co.), the Lifestream (St. Jude Medical Co.), and the BP-80 (Medtronic, BioMedicus Co.). The platelet count, lactate dehydrogenase (LDH), antithrombin III (AT III), thrombin-antithrombin complex (TAT), complements (C3, C4, and CH50), and immunoglobulins (IgG, IgA, and IgM) were measured before and after cardiopulmonary bypass (CPB). The platelet count was decreased more significantly by the HPM-15 than by any of the other pumps. The other parameters showed no difference among the 4 pumps. In clinical use, each of the 4 types of centrifugal pumps was safe.

  2. Spectrophotometric studies of holmium(III) chloride-aluminum(III) chloride vapor complexes

    SciTech Connect

    Williams, C.W.; Hessler, J.P.; Peterson, E.J.

    1980-01-01

    The gas complexation reactions between LnCl/sub 3/ and Al/sub 2/Cl/sub 6/ to yield molecular species of the form LnCl/sub 3/ (Al/sub 2/Cl/sub 6/)/sub x/ have been studied for a number of years. The spectrophotometric technique has been used to deduce the thermodynamic properties of the molecular species. We have studied the HoCl/sub 3/ (Al/sub 2/Cl/sub 6/)/sub x/ system from 600 to 900/sup 0/K and at Al/sub 2/Cl/sub 6/ pressures between 1 and 7 atm. The Ho/sup 3 +/ hypersensitive transition between /sup 5/I/sub 8/ and /sup 5/G/sub 6/ at 456 nm has been used to measure the complex vapor densities as a function of pressure and temperature. A temperature-dependence of the optical absorption spectrum was observed in samples with a constant Ho/sup 3 +/ ion density. These data cannot be understood in terms of the generally used treatment of molar absorptivity, but requires the introduction of an effective oscillator strength. A temperature-dependent oscillator effect is also observed and this is interpeted as evidence for the presence of multiple species with differing oscillator strengths. The consequence of these observations for the determination of equilibrium constants for the different species will be discussed.

  3. Open apex type III dens invaginatus: a rare case report of an endodontic retreatment with an anatomical redesign.

    PubMed

    Silva, Emmanuel Joao Nogueira Leal Da; Zaia, Alexandre Augusto

    2012-01-01

    Dens invaginatus is a critical condition for endodontic treatment. It frequently presents a complex internal anatomy and might be associated with incomplete root and apical development. This article presents one of the few reported cases of endodontic retreatment of Type III dens invaginatus. First, the internal anatomy was modified using burs under an operating microscope. Next, conventional chemical and mechanical preparation with hand files and 2.5% sodium hypochlorite was performed. Finally, an intracanal dressing with calcium hydroxide was used for nine months, at which point the anatomical features in the root canal system could be accessed. Adequate periradicular healing was observed and regression of the lesion was noted at the two-year follow-up. This case reinforces the idea that knowledge about the biologic aspects of endodontics, combined with adherence to technical standards, is helpful in resolving complex cases.

  4. Eslicarbazepine acetate: its effectiveness as adjunctive therapy in clinical trials and open studies.

    PubMed

    Shorvon, S D; Trinka, E; Steinhoff, B J; Holtkamp, M; Villanueva, V; Peltola, J; Ben-Menachem, E

    2017-03-01

    Eslicarbazepine acetate (ESL) is a once-daily antiepileptic drug that is approved as adjunctive therapy in adults with focal-onset seizures. Following oral administration, ESL is rapidly metabolized to its active metabolite, eslicarbazepine, which acts primarily by enhancing slow inactivation of voltage-gated sodium channels. The efficacy and safety/tolerability of ESL in the adjunctive setting were established in a comprehensive Phase III program (n = 1702 randomized patients) and this evidence has been supported by several open studies (n = 864). ESL treatment has demonstrated improvements in health-related quality of life, in both randomized clinical trials and open studies. ESL has also been shown to be usually well tolerated and efficacious when used in the adjunctive setting in elderly patients. The effectiveness of ESL as the only add-on to antiepileptic drug monotherapy has been demonstrated in a multinational study (n = 219), subgroup analyses of which have also shown it to be efficacious and generally well tolerated in patients who had previously not responded to carbamazepine therapy. Open studies have also demonstrated improvements in tolerability in patients switched overnight from oxcarbazepine to ESL. Due to differences in pharmacokinetics, pharmacodynamics, and metabolism, there may be clinical situations in which it is appropriate to consider switching patients from oxcarbazepine or carbamazepine to ESL.

  5. The Proteasome Acts as a Hub for Plant Immunity and Is Targeted by Pseudomonas Type III Effectors1[OPEN

    PubMed Central

    Sheikh, Arsheed; Gimenez-Ibanez, Selena

    2016-01-01

    Recent evidence suggests that the ubiquitin-proteasome system is involved in several aspects of plant immunity and that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their virulence. Here, we show that proteasome activity is strongly induced during basal defense in Arabidopsis (Arabidopsis thaliana). Mutant lines of the proteasome subunits RPT2a and RPN12a support increased bacterial growth of virulent Pseudomonas syringae pv tomato DC3000 (Pst) and Pseudomonas syringae pv maculicola ES4326. Both proteasome subunits are required for pathogen-associated molecular pattern-triggered immunity responses. Analysis of bacterial growth after a secondary infection of systemic leaves revealed that the establishment of systemic acquired resistance (SAR) is impaired in proteasome mutants, suggesting that the proteasome also plays an important role in defense priming and SAR. In addition, we show that Pst inhibits proteasome activity in a type III secretion-dependent manner. A screen for type III effector proteins from Pst for their ability to interfere with proteasome activity revealed HopM1, HopAO1, HopA1, and HopG1 as putative proteasome inhibitors. Biochemical characterization of HopM1 by mass spectrometry indicates that HopM1 interacts with several E3 ubiquitin ligases and proteasome subunits. This supports the hypothesis that HopM1 associates with the proteasome, leading to its inhibition. Thus, the proteasome is an essential component of pathogen-associated molecular pattern-triggered immunity and SAR, which is targeted by multiple bacterial effectors. PMID:27613851

  6. S-1 as adjuvant chemotherapy for stage III colon cancer: a randomized phase III study (ACTS-CC trial)

    PubMed Central

    Yoshida, M.; Ishiguro, M.; Ikejiri, K.; Mochizuki, I.; Nakamoto, Y.; Kinugasa, Y.; Takagane, A.; Endo, T.; Shinozaki, H.; Takii, Y.; Mochizuki, H.; Kotake, K.; Kameoka, S.; Takahashi, K.; Watanabe, T.; Watanabe, M.; Boku, N.; Tomita, N.; Nakatani, E.; Sugihara, K.

    2014-01-01

    Background S-1 is an oral fluoropyrimidine whose antitumor effects have been demonstrated in treating various gastrointestinal cancers, including metastatic colon cancer, when administered as monotherapy or in combination chemotherapy. We conducted a randomized phase III study investigating the efficacy of S-1 as adjuvant chemotherapy for colon cancer by evaluating its noninferiority to tegafur–uracil plus leucovorin (UFT/LV). Patients and methods Patients aged 20–80 years with curatively resected stage III colon cancer were randomly assigned to receive S-1 (80–120 mg/day on days 1–28 every 42 days; four courses) or UFT/LV (UFT: 300–600 mg/day and LV: 75 mg/day on days 1–28 every 35 days; five courses). The primary end point was disease-free survival (DFS) at 3 years. Results A total of 1518 patients (758 and 760 in the S-1 and UFT/LV group, respectively) were included in the full analysis set. The 3-year DFS rate was 75.5% and 72.5% in the S-1 and UFT/LV group, respectively. The stratified hazard ratio for DFS in the S-1 group compared with the UFT/LV group was 0.85 (95% confidence interval: 0.70–1.03), demonstrating the noninferiority of S-1 (noninferiority stratified log-rank test, P < 0.001). In the subgroup analysis, no significant interactions were identified between the major baseline characteristics and the treatment groups. Conclusion Adjuvant chemotherapy using S-1 for stage III colon cancer was confirmed to be noninferior in DFS compared with UFT/LV. S-1 could be a new treatment option as adjuvant chemotherapy for colon cancer. ClinicalTrials.gov NCT00660894. PMID:24942277

  7. Relaxation Models of the (110) Zinc-Blende III-V Semiconductor Surfaces: Density Functional Study

    SciTech Connect

    Ye, H.; Chen, G.; Wu, Y.; Zhu, Y.; Wei, S. H.

    2008-11-01

    Clean III-V zinc-blende (110) surfaces are the most extensively studied semiconductor surface. For conventional III-V compounds such as GaAs and InP, the surface relaxation follows a bond rotation relaxation model. However, for III-nitrides recent study indicates that they follow a bond-constricting relaxation model. First-principles atom relaxation calculations are performed to explore the origin of the difference between the two groups of materials. By analyzing the individual shift trends and ionic properties of the top layer anions and cations, we attribute the difference between the conventional and nitride III-V compounds to the strong electronegativity of N, which leads to the s{sup 2}p{sup 3} pyramid bond angle to be larger than the ideal one in bulk (109.5{sup o}). The general trends of the atomic relaxation at the III-nitrides (110) surfaces are explained.

  8. The nature of the intermediates in the reactions of Fe(III)- and Mn(III)-microperoxidase-8 with H(2)O(2): a rapid kinetics study.

    PubMed

    Primus, Jean-Louis; Grunenwald, Sylvie; Hagedoorn, Peter-Leon; Albrecht-Gary, Anne-Marie; Mandon, Dominique; Veeger, Cees

    2002-02-20

    Kinetic studies were performed with microperoxidase-8 (Fe(III)MP-8), the proteolytic breakdown product of horse heart cytochrome c containing an octapeptide linked to an iron protoporphyrin IX. Mn(III) was substituted for Fe(III) in Mn(III)MP-8. The mechanism of formation of the reactive metal-oxo and metal-hydroperoxo intermediates of M(III)MP-8 upon reaction of H(2)O(2) with Fe(III)MP-8 and Mn(III)MP-8 was investigated by rapid-scan stopped-flow spectroscopy and transient EPR. Two steps (k(obs1) and k(obs2)) were observed and analyzed for the reaction of hydrogen peroxide with both catalysts. The plots of k(obs1) as function of [H(2)O(2)] at pH 8.0 and pH 9.1 for Fe(III)MP-8, and at pH 10.2 and pH 10.9 for Mn(III)MP-8, exhibit saturation kinetics, which reveal the accumulation of an intermediate. Double reciprocal plots of 1/k(obs1) as function of 1/[H(2)O(2)] at different pH values reveal a competitive effect of protons in the oxidation of M(III)MP-8. This effect of protons is confirmed by the linear dependence of 1/k(obs1) on [H(+)] showing that k(obs1) increases with the pH. The UV-visible spectra of the intermediates formed at the end of the first step (k(obs1)) exhibit a spectrum characteristic of a high-valent metal-oxo intermediate for both catalysts. Transient EPR of Mn(III)MP-8 incubated with an excess of H(2)O(2), at pH 11.5, shows the detection of a free radical signal at g approximately equal to 2 and of a resonance at g approximately equal to 4 characteristic of a Mn(IV) (S = 3/2) species. On the basis of these results, the following mechanism is proposed: (i) M(III)MP-8-OH(2) is deprotonated to M(III)MP-8-OH in a rapid preequilibrium step, with a pK(a) = 9.2 +/- 0.9 for Fe(III)MP-8 and a pK(a) = 11.2 +/- 0.3 for Mn(III)MP-8; (ii) M(III)MP-8-OH reacts with H(2)O(2) to form Compound 0, M(III)MP8-OOH, with a second-order rate constant k(1) = (1.3 +/- 0.6) x 10(6) M(-1) x s(-1) for Fe(III)MP-8 and k(1) = (1.6 +/- 0.9) x 10(5) M(-1) x s(-1) for Mn(III

  9. Using phase II data for the analysis of phase III studies: An application in rare diseases.

    PubMed

    Wandel, Simon; Neuenschwander, Beat; Röver, Christian; Friede, Tim

    2017-06-01

    Clinical research and drug development in orphan diseases are challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug-approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. A Bayesian meta-analytic approach is used to inform the phase III study with phase II data. It is particularly attractive, since uncertainty of between-trial heterogeneity can be dealt with probabilistically, which is critical if the number of studies is small. Furthermore, it allows quantifying and discounting the phase II data through the predictive distribution relevant for phase III. A phase III design is proposed which uses the phase II data and considers approval based on a phase III interim analysis. The design is illustrated with a non-inferiority case study from a Food and Drug Administration approval in herpetic keratitis (an orphan disease). Design operating characteristics are compared to those of a traditional design, which ignores the phase II data. An analysis of the phase II data reveals good but insufficient evidence for non-inferiority, highlighting the need for a phase III study. For the phase III study supported by phase II data, the interim analysis is based on half of the patients. For this design, the meta-analytic interim results are conclusive and would justify approval. In contrast, based on the phase III data only, interim results are inconclusive and require further evidence. To accelerate drug development for orphan diseases, innovative study designs and appropriate methodology are needed. Taking advantage of randomized phase II data when analyzing phase III studies looks promising because the evidence from phase II supports informed decision-making. The implementation of the Bayesian design is straightforward with public software such as R.

  10. Sunitinib Plus Paclitaxel Versus Bevacizumab Plus Paclitaxel for First-Line Treatment of Patients With Advanced Breast Cancer: A Phase III, Randomized, Open-Label Trial

    PubMed Central

    Robert, Nicholas J.; Saleh, Mansoor N.; Paul, Devchand; Generali, Daniele; Gressot, Laurent; Copur, Mehmet S.; Brufsky, Adam M.; Minton, Susan E.; Giguere, Jeffrey K.; Smith, John W.; Richards, Paul D.; Gernhardt, Diana; Huang, Xin; Liau, Katherine F.; Kern, Kenneth A.; Davis, John

    2015-01-01

    Introduction A multicenter, open-label phase III study was conducted to test whether sunitinib plus paclitaxel prolongs progression-free survival (PFS) compared with bevacizumab plus paclitaxel as first-line treatment for patients with HER2− advanced breast cancer. Patients and Methods Patients with HER2− advanced breast cancer who were disease free for ≥ 12 months after adjuvant taxane treatment were randomized (1:1; planned enrollment 740 patients) to receive intravenous (I.V.) paclitaxel 90 mg/m2 every week for 3 weeks in 4-week cycles plus either sunitinib 25 to 37.5 mg every day or bevacizumab 10 mg/kg I.V. every 2 weeks. Results The trial was terminated early because of futility in reaching the primary endpoint as determined by the independent data monitoring committee during an interim futility analysis. At data cutoff, 242 patients had been randomized to sunitinib-paclitaxel and 243 patients to bevacizumab-paclitaxel. Median PFS was shorter with sunitinib-paclitaxel (7.4 vs. 9.2 months; hazard ratio [HR] 1.63 [95% confidence interval (CI), 1.18–2.25]; 1-sided P = .999). At a median follow-up of 8.1 months, with 79% of sunitinib-paclitaxel and 87% of bevacizumab-paclitaxel patients alive, overall survival analysis favored bevacizumab-paclitaxel (HR 1.82 [95% CI, 1.16–2.86]; 1-sided P = .996). The objective response rate was 32% in both arms, but median duration of response was shorter with sunitinib-paclitaxel (6.3 vs. 14.8 months). Bevacizumab-paclitaxel was better tolerated than sunitinib-paclitaxel. This was primarily due to a high frequency of grade 3/4, treatment-related neutropenia with sunitinib-paclitaxel (52%) precluding delivery of the prescribed doses of both drugs. Conclusion The sunitinib-paclitaxel regimen evaluated in this study was clinically inferior to the bevacizumab-paclitaxel regimen and is not a recommended treatment option for patients with advanced breast cancer. PMID:21569994

  11. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial.

    PubMed

    Robert, Nicholas J; Saleh, Mansoor N; Paul, Devchand; Generali, Daniele; Gressot, Laurent; Copur, Mehmet S; Brufsky, Adam M; Minton, Susan E; Giguere, Jeffrey K; Smith, John W; Richards, Paul D; Gernhardt, Diana; Huang, Xin; Liau, Katherine F; Kern, Kenneth A; Davis, John

    2011-04-01

    A multicenter, open-label phase III study was conducted to test whether sunitinib plus paclitaxel prolongs progression-free survival (PFS) compared with bevacizumab plus paclitaxel as first-line treatment for patients with HER2(-) advanced breast cancer. Patients with HER2(-) advanced breast cancer who were disease free for ≥ 12 months after adjuvant taxane treatment were randomized (1:1; planned enrollment 740 patients) to receive intravenous (I.V.) paclitaxel 90 mg/m(2) every week for 3 weeks in 4-week cycles plus either sunitinib 25 to 37.5 mg every day or bevacizumab 10 mg/kg I.V. every 2 weeks. [corrected] The trial was terminated early because of futility in reaching the primary endpoint as determined by the independent data monitoring committee during an interim futility analysis. At data cutoff, 242 patients had been randomized to sunitinib-paclitaxel and 243 patients to bevacizumab-paclitaxel. Median PFS was shorter with sunitinib-paclitaxel (7.4 vs. 9.2 months; hazard ratio [HR] 1.63 [95% confidence interval (CI), 1.18-2.25]; 1-sided P = .999). At a median follow-up of 8.1 months, with 79% of sunitinib-paclitaxel and 87% of bevacizumab-paclitaxel patients alive, overall survival analysis favored bevacizumab-paclitaxel (HR 1.82 [95% CI, 1.16-2.86]; 1-sided P = .996). The objective response rate was 32% in both arms, but median duration of response was shorter with sunitinib-paclitaxel (6.3 vs. 14.8 months). Bevacizumab-paclitaxel was better tolerated than sunitinib-paclitaxel. This was primarily due to a high frequency of grade 3/4, treatment-related neutropenia with sunitinib-paclitaxel (52%) precluding delivery of the prescribed doses of both drugs. The sunitinib-paclitaxel regimen evaluated in this study was clinically inferior to the bevacizumab-paclitaxel regimen and is not a recommended treatment option for patients with advanced breast cancer. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. Phase III integrated water recovery testing at MSFC - Partially closed hygiene loop and open potable loop results and lessons learned

    NASA Technical Reports Server (NTRS)

    Bagdigian, R. M.; Traweek, M. S.; Griffith, G. K.; Griffin, M. R.

    1991-01-01

    A series of tests has been conducted at the NASA Marshall Space Flight Center (MSFC) to evaluate the performance of a predevelopment water recovery system. Potable, hygiene, and urine reclamation subsystems were integrated with end-use equipment items and successfully operated in open and partially closed-loop modes, with man-in-the-loop, for a total of 28 days. Several significant subsystem physical anomalies were encountered during testing. Reclaimed potable and hygiene water generally met the current Space Station Freedom (SSF) water quality specifications for inorganic and microbiological constituents, but exceeded the maximum allowable concentrations for Total Organic Carbon (TOC). This paper summarizes the test objectives, system design, test activities/protocols, significant results/anomalies, and major lessons learned.

  13. Study of the Open Loop and Closed Loop Oscillator Techniques

    SciTech Connect

    Imel, George R.; Baker, Benjamin; Riley, Tony; Langbehn, Adam; Aryal, Harishchandra; Benzerga, M. Lamine

    2015-04-11

    This report presents the progress and completion of a five-year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques.The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this report we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems.

  14. Study of the open loop and closed loop oscillator techniques

    SciTech Connect

    Baker, Benjamin; Riley, Tony; Langbehn, Adam; Imel, George R.; Benzerga, M. Lamine; Aryal, Harishchandra

    2015-07-01

    This paper presents some aspects of a five year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques. The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this paper we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems. (authors)

  15. The High Risk of Infection With Delayed Treatment of Open Seymour Fractures: Salter-Harris I/II or Juxta-epiphyseal Fractures of the Distal Phalanx With Associated Nailbed Laceration.

    PubMed

    Reyes, Bryan A; Ho, Christine A

    2017-06-01

    To describe treatment methods and complication rates of all open Seymour fractures (Salter-Harris I/II or juxta-epiphyseal fractures of the distal phalanx of the hand with associated nailbed laceration) treated at or referred to a pediatric level 1 trauma center over a 10-year time period. We hypothesized that delayed treatment of Seymour fractures results in higher infectious complication rates. We identified all patients treated for open Seymour fractures at the orthopaedic hand clinic at our level 1 pediatric trauma center between August 2002 and December 2012. All charts were reviewed retrospectively. Patients were divided into groups based on timing and completeness of treatment. "Appropriate" treatment was defined as irrigation and debridement, fracture reduction, and antibiotic administration. "Partial" treatment was defined as any type of incomplete treatment; "Acute" treatment was defined as management within 24 hours of the injury; and "Delayed" as having received treatment after 24 hours from the time of injury. Statistical comparisons were performed using the Fisher exact test. A total of 34 patients treated for 35 Seymour fractures met the inclusion criteria. In total, 31% (11/35) received acute, appropriate treatment, 37% (13/35) received acute, partial treatment, and 31% (11/35) received delayed treatment. There were 7 infectious complications: 2 superficial and 5 osteomyelitis. No infections occurred in the acutely, appropriately treated group (infection rate 0%, 0/11), 2 occurred in the acutely, partially treated group (15%, 2/13), and 5 occurred in the delayed treatment group (45%, 5/11). The timing and quality of treatment of open Seymour fractures significantly influences infection rates. This study highlights the importance of timely and appropriate treatment of this seemingly innocuous fracture. Level III-retrospective study, therapeutic.

  16. A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma.

    PubMed

    Westphal, Manfred; Heese, Oliver; Steinbach, Joachim P; Schnell, Oliver; Schackert, Gabriele; Mehdorn, Maximilian; Schulz, Dirk; Simon, Matthias; Schlegel, Uwe; Senft, Christian; Geletneky, Karsten; Braun, Christian; Hartung, Joachim G; Reuter, Dirk; Metz, Monika Warmuth; Bach, Ferdinand; Pietsch, Torsten

    2015-03-01

    A randomised, open label phase III trial was conducted to evaluate efficacy of nimotuzumab, a monoclonal antibody against epidermal growth factor receptor (EGF-R) added to standard therapy for newly diagnosed glioblastoma. 149 glioblastoma patients stratified as with or without residual tumour were randomly assigned to receive either intravenous nimotuzumab 400mg weekly added to standard radiochemotherapy followed by 400mg biweekly after twelve weeks or standard radiochemotherapy. Progression status after 52 weeks (12moPFS) and progression-free survival (PFS) based on Macdonald criteria were co-primary and overall survival (OS), toxicity and quality of life secondary end-points. 142 patients were evaluated for efficacy (per protocol cohort). 12 moPFS was 25.6% in the experimental arm and 20.3% in the control group. In residual tumour patients (n=81) median PFS was 5.6 versus 4.0 months, (hazard ratio (HR), 0.87; 95% confidence interval (CI), 0.55-1.37), for patients without residual tumour (n=61) it was 10.6 versus 9.9 months, (HR, 1.01; 95% CI, 0.57-1.77). Median OS in patients with residual tumour was 19.5 versus 16.7 months, (HR, 0.90; 95% CI, 0.52-1.57; P=0.7061), for patients without 23.3 versus 21.0 months (HR, 0.77; 95% CI, 0.41-1.44; P=0.4068). A small cohort of MGMT non-methylated patients with residual tumour showed PFS of 6.2 versus 4.0 months (HR, 0.77; 95% CI, 0.35-1.67; P=0.4997) and OS of 19.0 versus 13.8 months (HR, 0.66; 95% CI, 0.27-1.64; P=0.3648). EGF-R amplification did not correlate with clinical efficacy of nimotuzumab. Nimotuzumab was well tolerated. This study, albeit negative, contains hypothesis generating signals supporting evaluation of correlative, efficacy-predicting tumour parameters for nimotuzumab in the treatment of glioblastoma. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial.

    PubMed

    Pujade-Lauraine, Eric; Hilpert, Felix; Weber, Béatrice; Reuss, Alexander; Poveda, Andres; Kristensen, Gunnar; Sorio, Roberto; Vergote, Ignace; Witteveen, Petronella; Bamias, Aristotelis; Pereira, Deolinda; Wimberger, Pauline; Oaknin, Ana; Mirza, Mansoor Raza; Follana, Philippe; Bollag, David; Ray-Coquard, Isabelle

    2014-05-01

    In platinum-resistant ovarian cancer (OC), single-agent chemotherapy is standard. Bevacizumab is active alone and in combination. AURELIA is the first randomized phase III trial to our knowledge combining bevacizumab with chemotherapy in platinum-resistant OC. Eligible patients had measurable/assessable OC that had progressed < 6 months after completing platinum-based therapy. Patients with refractory disease, history of bowel obstruction, or > two prior anticancer regimens were ineligible. After investigators selected chemotherapy (pegylated liposomal doxorubicin, weekly paclitaxel, or topotecan), patients were randomly assigned to single-agent chemotherapy alone or with bevacizumab (10 mg/kg every 2 weeks or 15 mg/kg every 3 weeks) until progression, unacceptable toxicity, or consent withdrawal. Crossover to single-agent bevacizumab was permitted after progression with chemotherapy alone. The primary end point was progression-free survival (PFS) by RECIST. Secondary end points included objective response rate (ORR), overall survival (OS), safety, and patient-reported outcomes. The PFS hazard ratio (HR) after PFS events in 301 of 361 patients was 0.48 (95% CI, 0.38 to 0.60; unstratified log-rank P < .001). Median PFS was 3.4 months with chemotherapy alone versus 6.7 months with bevacizumab-containing therapy. RECIST ORR was 11.8% versus 27.3%, respectively (P = .001). The OS HR was 0.85 (95% CI, 0.66 to 1.08; P < .174; median OS, 13.3 v 16.6 months, respectively). Grade ≥ 2 hypertension and proteinuria were more common with bevacizumab. GI perforation occurred in 2.2% of bevacizumab-treated patients. Adding bevacizumab to chemotherapy statistically significantly improved PFS and ORR; the OS trend was not significant. No new safety signals were observed.

  18. Postoperative pain after arthroscopic versus open rotator cuff repair. A prospective study.

    PubMed

    Pham, T T; Bayle Iniguez, X; Mansat, P; Maubisson, L; Bonnevialle, N

    2016-02-01

    Although the arthroscopic technique is becoming the gold standard for rotator cuff tendon repair, there is no proof that this technique results in less postoperative pain compared to open repair. The aim of this study was to prospectively compare the postoperative pain level after arthroscopic or open rotator cuff repair and to define factors that could influence its course. Between January 2012 and January 2013, 95 patients were operated for a rotator cuff tear: 45 using an arthroscopic technique and 50 an open technique. Daily analgesic use and self-evaluation of pain level using a visual analogic scale were recorded preoperatively and twice a day postoperatively during the first 6 weeks. These data were compared between the two groups and analyzed according to patients' demographic data and preoperative evaluation of the tear. The preoperative pain level was equivalent in the two groups (P=0.22). Postoperatively, level-2 analgesic medication use was greater in the arthroscopic group after the 4th week (P=0.01). A pain-free shoulder was obtained before the 6th week in 75% and 66% of the patients after arthroscopic or open repair, respectively (P=0.34). There was a positive correlation between the preoperative and postoperative pain level (r=0.25; P=0.02). Work compensation patients experienced more pain postoperatively (P=0.08). Level-III analgesic medication use was greater for patients with massive rotator cuff tear (P=0.001). No evidence was found on the superiority of arthroscopy versus open repair of rotator cuff tear concerning the postoperative pain level. The choice of the surgical technique should not be based on this argument. II. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  19. Course Evaluation in Open and Distance Learning: A Case Study from Indira Gandhi National Open University

    ERIC Educational Resources Information Center

    Gaba, Ashok K.; Dash, Nirod K.

    2004-01-01

    The success of any open and distance learning course depends on how well it is designed, executed, and evaluated. Evaluation of a course not only demonstrates its strengths, but also points out any inherent shortcomings in the course. This is why course evaluation constitutes an important function in an open and distance learning system. The…

  20. Opening Education: Policies and Practices from Open and Distance Education. Routledge Studies in Distance Education Series.

    ERIC Educational Resources Information Center

    Evans, Terry, Ed.; Nation, Daryl, Ed.

    The overall theme of this book is the relationships between government and organizational policies and the work of practitioners in open and distance learning. The book explores a selection of international examples, many of which concern the use of new technologies for opening education. The contributors, many of whom are recognized experts,…

  1. Course Evaluation in Open and Distance Learning: A Case Study from Indira Gandhi National Open University

    ERIC Educational Resources Information Center

    Gaba, Ashok K.; Dash, Nirod K.

    2004-01-01

    The success of any open and distance learning course depends on how well it is designed, executed, and evaluated. Evaluation of a course not only demonstrates its strengths, but also points out any inherent shortcomings in the course. This is why course evaluation constitutes an important function in an open and distance learning system. The…

  2. Opening Education: Policies and Practices from Open and Distance Education. Routledge Studies in Distance Education Series.

    ERIC Educational Resources Information Center

    Evans, Terry, Ed.; Nation, Daryl, Ed.

    The overall theme of this book is the relationships between government and organizational policies and the work of practitioners in open and distance learning. The book explores a selection of international examples, many of which concern the use of new technologies for opening education. The contributors, many of whom are recognized experts,…

  3. STUDIES ON NATURAL IMMUNITY TO PNEUMOCOCCUS TYPE III

    PubMed Central

    Enders, John F.; Shaffer, Morris F.; Wu, Chao-Jen

    1936-01-01

    Among the experimental findings reported in this paper to which we wish to give particular emphasis are the following: 1. The results which follow the intravenous injection into rabbits of two strains of Pneumococcus Type III of different degrees of virulence vary with the state of the capsule. Thus when this structure is completely developed both remain in the blood. A culture of either strain begins to become susceptible to the blood-clearing mechanism contemporaneously with the onset of capsular degeneration and the initiation of other concomitant changes at the surface of the organism (cf Paper II), which occur much earlier with the less virulent strain. 2. When, in either case, removal from the blood stream occurs, this is effected by the phagocytic cells of the body. There is no suggestion that a new or unknown mechanism is involved. The greatest share of the burden is borne by the fixed phagocytic cells of the liver and spleen, and to a less extent by those of the lung and bone marrow. Nevertheless, it has been demonstrated that the polymorphonuclear leucocytes may also participate. 3. Phagocytosis by the leucocytes of the normal animal either in intro or in vivo has been observed only at such a time as the capsule has become impaired. Ingestion of the organisms by the fixed tissue cells appears also to be effective only under the same condition and is accordingly observed with much younger cultures of the less virulent strain. 4. Following their removal from the blood and their accumulation within the fixed phagocytes of the organs, destruction of most of the cocci proceeds within 2 to 4 hours. Both strains are destroyed provided they are in the state favorable to phagocytic attack. 5. Evidence has been presented which indicates that just as in vitro, so in a local area of inflammation within the body, aging with attendant capsular loss and increasing susceptibility to phagocytosis may take place. 6. With organisms from either strain a variable period of

  4. Photometric and spectroscopic study of the ultra-faint Milky Way satellite Pegasus III

    NASA Astrophysics Data System (ADS)

    Kim, Dongwon; Jerjen, Helmut; Geha, Marla C.; Chiti, Anirudh; Milone, Antonino; Da Costa, Gary S.; Mackey, Dougal; Frebel, Anna; Conn, Blair

    2017-01-01

    Pegasus III (Peg III) is one of the few known ultra-faint dwarf (UFD) satellite galaxies in the outer halo (R >150 kpc) of the Milky Way (MW). We present results from a recent study of Peg III using Magellan/IMACS and Keck/DEIMOS. Our newly-measured structural parameters confirm that Peg III is large (rh = 53±14pc), elongated (∈ = 0.38+0.22-0.38 ), and faint (MV=-3.4±0.4 mag) — indicative of its nature as a dwarf rather than a globular cluster. In the color-magnitude diagram, Peg III is well described by an old (>12Gyr) and metal-poor ([Fe/H]<-2.0 dex) stellar population at a heliocentric distance of 215±12 kpc. Using spectroscopic measurements of individual stars, we identify seven kinematic members of Peg III. The Ca II triplet lines of the brightest members verify that Peg III indeed contains stars with metallicity as low as [Fe/H]=-2.55±0.15 dex. The systemic velocity and velocity dispersion of Peg III are -222.9±2.6 km/s and 5.4+3.0-2.5 km/s, respectively. The inferred dynamical mass within the half-light radius of 1.4+3.0-1.1×106M⊙, and the mass-to-light ratio of M/LV = 1470+5660-1240M⊙/L⊙ provide further evidence that Peg III is a bona fide UFD. Peg III and another distant UFD Pisces II lie relatively close to each other (△dspatial=43±19 kpc) and share similar systemic radial velocities (△vGSR=12.3±3.7 km/s), which suggests that they may share a common origin.

  5. Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy.

    PubMed

    Felip, Enriqueta; Hirsh, Vera; Popat, Sanjay; Cobo, Manuel; Fülöp, Andrea; Dayen, Charles; Trigo, José M; Gregg, Richard; Waller, Cornelius F; Soria, Jean-Charles; Goss, Glenwood D; Gordon, James; Wang, Bushi; Palmer, Michael; Ehrnrooth, Eva; Gadgeel, Shirish M

    2017-06-23

    In the phase III LUX-Lung 8 trial, afatinib significantly improved progression-free survival (PFS) and overall survival (OS) versus erlotinib in patients with squamous cell carcinoma (SCC) of the lung progressing during or after platinum-based chemotherapy. Patient-reported outcomes (PROs) and health-related quality of life (QoL) in these patients are presented. Patients (n = 795) were randomized 1:1 to oral afatinib (40 mg/d) or erlotinib (150 mg/d). PROs were collected (baseline, every 28 days until progression, 28 days after discontinuation) using the European Organization for Research and Treatment of Cancer QoL questionnaire and lung cancer-specific module. The percentage of patients improved during therapy, time to deterioration (TTD), and changes over time were analyzed for prespecified lung cancer-related symptoms and global health status (GHS)/QoL. Questionnaire compliance was 77.3% to 99.0% and 68.7% to 99.0% with afatinib and erlotinib, respectively. Significantly more patients who received afatinib versus erlotinib experienced improved scores for GHS/QoL (36% vs. 28%; P = .041) and cough (43% vs. 35%; P = .029). Afatinib significantly delayed TTD in dyspnea (P = .008) versus erlotinib, but not cough (P = .256) or pain (P = .869). Changes in mean scores favored afatinib for cough (P = .0022), dyspnea (P = .0007), pain (P = .0224), GHS/QoL (P = .0320), and all functional scales. Differences in adverse events between afatinib and erlotinib, specifically diarrhea, did not affect GHS/QoL. In patients with SCC of the lung, second-line afatinib was associated with improved prespecified disease-related symptoms and GHS/QoL versus erlotinib, complementing PFS and OS benefits with afatinib. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  6. Study of the radon released from open drill holes

    SciTech Connect

    Pacer, J C

    1981-06-01

    The radon emanating from three open drill holes was measured at a site of known uranium mineralization in the Red Desert of south central Wyoming. The radon flux from the soil and drill holes was measured by the accumulator method with activated charcoal cartridges. The surface soil was found to release radon at an average rate of 0.41 atoms/cm/sup 2//sec; the radon emanating from the holes was more variable than that from the soil. The three holes studied released an average of 47 atoms/cm/sup 2//sec of radon. This average is equivalent to the radon released to the atmosphere by 14.5 ft/sup 2/ of soil. The data indicate that the radon emanated from an open drill hole is not as significant as other possible activities at a drill site (i.e. digging a trench or drilling a hole) or from household activities involving the usage of water.

  7. Anthem simulational studies of the plasma opening switch

    SciTech Connect

    Mason, R.J.

    1992-01-01

    For a deeper understanding of the physical processes governing the Plasma Opening Switch (POS) we use the ANTHEM 2D implicit simulation code to study: (1) ion dynamical effects on electrohydrodynamic (EHD) waves propagating along steep density interfaces in the switch plasmas. At radial interfaces where the density jumps toward the anode, these waves can drive a finger of magnetic field into the plasma toward the load. Ion dynamics can open the rear of such fingers into a wedge-like density gap. Then: (2) we examine ion effects in uniform switch plasmas. These first develop potential hill structures at the drive edge of the cathode from the competition between electron velocity advection and EHD magnetic exclusion waves. Magnetic pressure gradients at the hill periphery and EHD effects then establish a density gap propagating along the cathode with radial electron emission from its tip. Similar results are obtained under both multi-fluid and PIC modeling of the plasma components.

  8. Anthem simulational studies of the plasma opening switch

    SciTech Connect

    Mason, R.J.

    1992-07-01

    For a deeper understanding of the physical processes governing the Plasma Opening Switch (POS) we use the ANTHEM 2D implicit simulation code to study: (1) ion dynamical effects on electrohydrodynamic (EHD) waves propagating along steep density interfaces in the switch plasmas. At radial interfaces where the density jumps toward the anode, these waves can drive a finger of magnetic field into the plasma toward the load. Ion dynamics can open the rear of such fingers into a wedge-like density gap. Then: (2) we examine ion effects in uniform switch plasmas. These first develop potential hill structures at the drive edge of the cathode from the competition between electron velocity advection and EHD magnetic exclusion waves. Magnetic pressure gradients at the hill periphery and EHD effects then establish a density gap propagating along the cathode with radial electron emission from its tip. Similar results are obtained under both multi-fluid and PIC modeling of the plasma components.

  9. Study of Intermediate Age (~10-30 Myr) Open Clusters

    NASA Astrophysics Data System (ADS)

    Olguin, Lorenzo; Michel, Raul; Contreras, Maria; Hernandez, Jesus; Schuster, William; Chavarria-Kleinhenn, Carlos

    2013-07-01

    We present the study of a sample of intermediate age open clusters (age ~ 10-30 Myr) using optical (UBVRI) and infrared photometric data. Optical photometry was obtained as part of the San Pedro Martir Open Clusters Project (SPM-OCP, Schuster et al. 2007; Michel et al. 2013). Infrared photometry was retrieved from 2MASS public data archive and WISE database. Open clusters included in the SPM-OCP were selected from catalogues presented by Dias et al. (2002) and Froebrich, Scholz & Raftery (2007). One of the main goals of the SPM-OCP is to compile a self-consistent and homogeneous set of cluster fundamental parameters such as reddening, distance, age, and metallicity whenever possible. In this work, we have analyzed a set of 25 clusters from the SPM-OCP with estimated ages between 10 and 30 Myr. Derived fundamental parameters for each cluster in the sample as well as an example of typical color-color and color-magnitude diagrams are presented. Kinematic membership was established by using proper motion data taken from the literature. Based on infrared photometry, we have searched for candidate stars to posses a circumstellar disk within each clusters. For those selected candidates a follow-up spectroscpic study is being carried out. This work was partially supported by UNAM-PAPIIT grant IN-109311.

  10. Evaluation of the MOZAIC Capacitive Hygrometer during the airborne field study CIRRUS-III

    NASA Astrophysics Data System (ADS)

    Neis, P.; Smit, H. G. J.; Krämer, M.; Spelten, N.; Petzold, A.

    2014-09-01

    The MOZAIC Capacitive Hygrometer (MCH) is usually operated onboard of passenger aircraft in the framework of MOZAIC (Measurement of Ozone by AIRBUS In-Service Aircraft). In order to evaluate the performance of the MCH, it was operated aboard a Learjet 35A aircraft as part of the CIRRUS-III field study together with a closed-cell Lyman-α fluorescence hygrometer (FISH) and an open path tunable diode laser system (OJSTER) for water vapour measurement. After reducing the data set to MOZAIC-relevant conditions, the 1Hz relative humidity (RH) cross correlation between MCH and reference instruments FISH (clear sky) and OJSTER (in-cirrus) yielded a remarkably good agreement of R2 = 0.97 and slope m = 0.96 and provided the MCH uncertainty of 5% RH. Probability distribution functions of RH deduced from MCH and reference instruments agreed well over the entire range of observations. The main limitation for the use of MCH data is related to sensor temperatures below the calibration limit of Tsensor = -40 °C (corresponds to ambient temperature of Tambient = -70 °C at typical cruising speed of long-haul passenger aircraft), which causes a delay in the sensor's time response. Good performance of MCH for clear sky as well as for in-cirrus conditions demonstrated the sensor robustness also for operation inside ice clouds.

  11. Oil geochemistry study; Blocks III and IV Bachaquedro Field, Lake Maracaibo, Venezuela

    SciTech Connect

    Patterson, B.A.; Villarroel, H.G. de; Rondon, L.

    1996-08-01

    Blocks III and IV Bachaquero, Field, located on the east side of Lake Maracaibo, comprise an area of 40 square kilometers. In 1956 the discovery well penetrated oil saturated sands in a south dipping homoclinal structure. In 1958 production reached a maximum of 245,000 barrels per day of moderate gravity oil from three Miocene age Lagunillas Formation sands, designated as L, M, and N. The Bachaquero Field has experienced production problems including high gas-oil ratios from M and N sands to the north, high water cuts in all three sands to the south, and low production rates in the southeast. In addition, the vertical and lateral continuity of the oil pools are unknown. High resolution gas chromatography and analysis of biological markers was employed in order to resolve the continuity of the oil pools, determine genetic origin of the oils, and shed light on erratic production. Oil in the L sands are vertically discontinuous from oil in the M+N sands. The two oil pools appear laterally continuous within the study area, indicating absence of fault barriers. Well VLD 311, open to both L and M sands, produces a mix of oils, but with a strong contribution from the M sand. Bachaquero Field reservoirs were charged with oil from two different facies of the Upper Cretaceous La Luna or perhaps from La Luna and Colon source rocks as the stratigraphically younger L sands contain less mature oil with a stronger terrigenous imprint than oil the M and N sands.

  12. Inbreeding and true seed in tetrasomic potato. III. Early selection for seedling vigor in open-pollinated populations.

    PubMed

    Golmirzaie, A; Ortiz, R

    2002-01-01

    Tuber yield in open-pollinated (OP) offspring of potato cultivars appears to be correlated with the proportion of hybrids within each population. OP true potato seed (TPS) from ten selected clones was tested in an experiment at two Peruvian locations, San Ramón (mid-altitude warm tropics) and Huancayo (highland cool tropics), to investigate the early selection effect on OP populations. Another experiment in La Molina (dry coast) was included to confirm the results from these other two locations. The results clearly showed that plant survival, tuber yield and berry number can be increased by a strong early selection. Likewise, the results suggested that the most-promising OP offspring for TPS production could be derived from tetraploid clones with a high rate of outcrossing. This experiment demonstrates that high tuber yield may be obtained in OP TPS cultivars with little effort, using early selection for seedling vigor in the nursery. Genetic interpretation of this response to early selection indicates that both the intensity of selection and non-additive genetic variation for tuber yield account for these observed gains.

  13. [Synthesis of hydroxamic acids and study of their complexes with iron (II) and (III) ions].

    PubMed

    Nenortiene, Palma; Sapragoniene, Marija; Stankevicius, Antanas

    2002-01-01

    Hydroxamic acids are widespread in the tissues of plants, in metabolites of bacteria and fungi, including complex compounds with metal ions. These acids have wide spectrum of biological activity and therefore are perspective reagents for analysis of chemical elements. Fourteen aliphatic and aromatic derivatives of hydroxamic acids have been synthesized from esters of carboxylic acids. Photometric reactions of hydroxamic acids with iron (II) and (III) were investigated. Complex formation of iron (II) and (III) depending on pH was studied with series of synthesized hydroxamic acids: octanohydroxamic, maleic hydroxamic, 2-hydroxybenzoxydroxamic, benzoxydroxamic, phthalmonoxydroxamic and 3-metoxybenzohydroxamic acids. Composition of iron (III) complexes with 2-hydroxybenzohydroxamic, octanoxydroxamic, 3-metoxybenzohydroxamic acids and iron (II) with 2-hydroxybenzohydroxamic acid was studied by methods of mole ratio and isomolar solutions. Sensitivity of reagents was evaluated by values of absorption coefficients (epsilon). Stability of complexes in water and organic solvents was investigated. Interaction between iron (III) and hydroxamic acids (octanoxydroxamic, 2-hydroxybenzohydroxamic, 3-metoxybenzohydroxamic) have been applied for quantitative photometric analysis of iron (III) salts. Color reaction of iron (II) with 2-hydroxybenzohydroxamic acid was applied for quantitative photometric determination of iron (II) salts. 3-Metoxybenzohydroxamic acid was proposed as a new indicator for complexonometric analysis of iron (III). Chelatometric titration of iron (III) using this indicator is not influenced by copper, cobalt, zinc, manganese, so this methods is recommended for iron quantity detection in antianemic drugs, which are composed of latter microelements. Synthesis procedure of 2-benzoylamino-3-arylacrylhydroxamic acids from saturated azlactones was created. Color and precipitate reactions of iron (II) and (III), copper (II), nickel (II) and cobalt (II) ions with

  14. Open source projects in software engineering education: a mapping study

    NASA Astrophysics Data System (ADS)

    Nascimento, Debora M. C.; Almeida Bittencourt, Roberto; Chavez, Christina

    2015-01-01

    Context: It is common practice in academia to have students work with "toy" projects in software engineering (SE) courses. One way to make such courses more realistic and reduce the gap between academic courses and industry needs is getting students involved in open source projects (OSP) with faculty supervision. Objective: This study aims to summarize the literature on how OSP have been used to facilitate students' learning of SE. Method: A systematic mapping study was undertaken by identifying, filtering and classifying primary studies using a predefined strategy. Results: 72 papers were selected and classified. The main results were: (a) most studies focused on comprehensive SE courses, although some dealt with specific areas; (b) the most prevalent approach was the traditional project method; (c) studies' general goals were: learning SE concepts and principles by using OSP, learning open source software or both; (d) most studies tried out ideas in regular courses within the curriculum; (e) in general, students had to work with predefined projects; (f) there was a balance between approaches where instructors had either inside control or no control on the activities performed by students; (g) when learning was assessed, software artefacts, reports and presentations were the main instruments used by teachers, while surveys were widely used for students' self-assessment; (h) most studies were published in the last seven years. Conclusions: The resulting map gives an overview of the existing initiatives in this context and shows gaps where further research can be pursued.

  15. Synthesis, spectroscopic characterization and antibacterial studies of lanthanide(III) Schiff base complexes containing N, O donor atoms

    NASA Astrophysics Data System (ADS)

    Lekha, L.; Raja, K. Kanmani; Rajagopal, G.; Easwaramoorthy, D.

    2014-01-01

    A series of six Ln(III) Schiff base complexes, Pr(III), Sm(III), Gd(III), Tb(III), Er(III) and Yb(III), were synthesized using sodium salt of Schiff base, 2-[(5-bromo-2-hydroxy-benzylidene)-amino]-3-hydroxy-propionic acid, derived from L-serine and 5-bromosalicylaldehyde. These complexes having general formula [Ln(L)(NO3)2(H2O)]·NO3 were characterized by elemental analysis, conductivity measurements, UV-Vis, FT-IR, mass spectrometry and fluorescence studies. Elemental analysis and conductivity measurements suggest the complexes have a 1:1 stoichiometry. From the spectral studies it has been concluded that Ln(III) complexes display eight coordination. The Schiff base and its Ln(III) metal complexes have also been screened for their antibacterial activities by Agar diffusion method.

  16. Prognostic indicators for no light perception after open-globe injury: eye injury vitrectomy study.

    PubMed

    Feng, Kang; Hu, Yun Tao; Ma, Zhizhong

    2011-10-01

    To describe ocular characteristics, surgical interventions, and anatomic and visual outcomes of traumatized eyes with no light perception (NLP) following open-globe injury and to investigate prognostic predictors for NLP cases after open-globe injury. Interventional case series study. Thirty-three traumatized eyes with NLP were selected from the Eye Injury Vitrectomy Study database, a hospital-based multicenter prospective cohort study. Inclusion criteria were NLP cases following open-globe injury with outcomes of anatomic restoration, phthisis bulbi, or enucleation. Exclusion criteria were cases with missing records, undergoing vitrectomy after injury at nonparticipating hospitals, direct optic head injury, endophthalmitis, and hypotonous or silicone oil-sustained eyes. All cases underwent vitreoretinal surgery or enucleation after exploratory surgery and were followed up for at least 6 months. Two outcomes were assessed: favorable outcome (anatomically restored eye globes with light perception [LP] or better vision) and unfavorable outcome (NLP, phthisis bulbi, or enucleation). The following 7 risk factors were significant between the 2 groups: rupture (P = .021); open globe III (P = .046); scleral wound ≥10 mm (P = .001); ciliary body damage (P < .001); severe intraocular hemorrhage (P = .005); closed funnel retinal detachment or retinal prolapse (P = .005); and choroidal damage (P = .001). These 7 risk factors are possible predictors of poor prognosis. Traumatized eyes with NLP can be anatomically restored with LP or better vision if vitreoretinal surgery is attempted, and a favorable anatomic and visual outcome is increased by having a decreased number of these risk factors. Copyright © 2011 Elsevier Inc. All rights reserved.

  17. An XMM-Newton view of the young open cluster NGC 6231 - III. Optically faint X-ray sources

    NASA Astrophysics Data System (ADS)

    Sana, H.; Rauw, G.; Sung, H.; Gosset, E.; Vreux, J.-M.

    2007-05-01

    We discuss the properties of the X-ray sources with faint optical counterparts in the very young open cluster NGC 6231. From their positions in the Hertzsprung-Russell diagram, we find that the bulk of these objects probably consists of low-mass pre-main-sequence (PMS) stars with masses in the range 0.3-3.0 Msolar. The age distribution of these objects indicates that low-mass star formation in NGC 6231 started more than 10Myr ago and culminated in a starburst-like event about 1-4Myr ago when the bulk of the low-mass PMS stars as well as the massive cluster members formed. We find no evidence for a spatial age gradient that could point towards a sequential star formation process. Only a few X-ray sources have counterparts with a reddening exceeding the average value of the cluster or with infrared colours indicating the presence of a moderate near-IR excess. The X-ray spectra of the brightest PMS sources are best fitted by rather hard thermal plasma models and a significant fraction of these sources display flares in their light curve. The X-ray brightest flaring sources have decay times between 2 and 16ks. The X-ray selected PMS stars in NGC 6231 have logLX/Lbol values that increase strongly with decreasing bolometric luminosity and can reach a saturation level (logLX/Lbol ~ -2.4) for non-flaring sources and even more extreme values during flares. Based on observations with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA member states and the USA (NASA). E-mail: hsana@eso.org ‡ FNRS Research Associate (Belgium).

  18. Preservation of condyle and disc in the surgical treatment of type III temporomandibular joint ankylosis: a long-term follow-up clinical study of 111 joints.

    PubMed

    Jakhar, S K; Agarwal, M; Gupta, D K; Tiwari, A D

    2013-06-01

    The purpose of this study was to establish the role of retaining the condyle and disc in the treatment of type III ankylosis, by clinical and computed tomography (CT) evaluation. A total of 90 patients with type III ankylosis met the inclusion criteria; 42 patients had left temporomandibular joint (TMJ) ankylosis, 27 patients had right TMJ ankylosis, and 21 had bilateral TMJ ankylosis, thus a total 111 joints were treated. Considerable improvements in mandibular movement and maximum mouth opening were noted in all patients. At the end of a minimum follow-up of 2 years, the mean inter-incisal mouth opening was 30.7 mm. Postoperative occlusion was normal in all patients, and open bite did not occur in any case because the ramus height was maintained through preservation of the pseudo-joint. Only three patients had recurrence of ankylosis, which was due to a lack of postoperative physiotherapy. The advantages of condyle and disc preservation in type III ankylosis are: (1) surgery is relatively safe; (2) the disc helps to prevent recurrence of ankylosis; (3) the existing ramus height is maintained; (4) the growth site is preserved; and (5) there is no need to reconstruct the joint with autogenous or alloplastic material. It is recommended that the disc and condyle are preserved in type III TMJ ankylosis.

  19. A Study of Innovative Features in Scholarly Open Access Journals

    PubMed Central

    2011-01-01

    Background The emergence of the Internet has triggered tremendous changes in the publication of scientific peer-reviewed journals. Today, journals are usually available in parallel electronic versions, but the way the peer-review process works, the look of articles and journals, and the rigid and slow publication schedules have remained largely unchanged, at least for the vast majority of subscription-based journals. Those publishing firms and scholarly publishers who have chosen the more radical option of open access (OA), in which the content of journals is freely accessible to anybody with Internet connectivity, have had a much bigger degree of freedom to experiment with innovations. Objective The objective was to study how open access journals have experimented with innovations concerning ways of organizing the peer review, the format of journals and articles, new interactive and media formats, and novel publishing revenue models. Methods The features of 24 open access journals were studied. The journals were chosen in a nonrandom manner from the approximately 7000 existing OA journals based on available information about interesting journals and include both representative cases and highly innovative outlier cases. Results Most early OA journals in the 1990s were founded by individual scholars and used a business model based on voluntary work close in spirit to open-source development of software. In the next wave, many long-established journals, in particular society journals and journals from regions such as Latin America, made their articles OA when they started publishing parallel electronic versions. From about 2002 on, newly founded professional OA publishing firms using article-processing charges to fund their operations have emerged. Over the years, there have been several experiments with new forms of peer review, media enhancements, and the inclusion of structured data sets with articles. In recent years, the growth of OA publishing has also been

  20. Mechanistic studies of uncatalyzed and ruthenium(III)-catalyzed oxidation of the antibiotic drug chloramphenicol by hexacyanoferrate(III) in aqueous alkaline medium: a comparative kinetic study.

    PubMed

    Meti, M D; Byadagi, K S; Nandibewoor, S T; Chimatadar, S A

    The kinetics of oxidation of the antibiotic drug chloramphenicol (CHP) by hexacyanoferrate(III) (HCF) has been investigated spectrophotometrically both in the absence and presence of ruthenium(III) catalyst in aqueous alkaline medium at 25 °C and at constant ionic strength of 1.10 mol dm(-3). The stoichiometry is identical in both cases, i.e. [CHP]/[HCF] = 1:2. The oxidation products were identified by TLC and spectral studies such as GC-MS, IR, and (1)H NMR. In both catalyzed and uncatalyzed reactions, the order with respect to the concentration of HCF is unity, whereas the order with respect to the concentration of CHP and the concentration of OH(-) is less than unity over the concentration range studied. The order with respect to the concentration of Ru(III) is unity. The reaction in the presence of Ru(III) is approximately tenfold faster than the uncatalyzed reaction. The active species of oxidant and catalyst are [Fe(CN)6](3-) and [Ru(H2O)5(OH)](2+), respectively. On the basis of experimental results suitable mechanisms are proposed. The reaction constants involved in the different steps of the reaction mechanisms were calculated for both cases. The catalytic constant was also calculated for the catalyzed reaction at different temperatures. The activation parameters with respect to the slow step of the mechanism and thermodynamic quantities are also determined.

  1. Immunochemical studies of Lolium perenne (rye grass) pollen allergens, Lol p I, II, and III.

    PubMed

    Ansari, A A; Kihara, T K; Marsh, D G

    1987-12-15

    It was reported earlier that human immune responses to three perennial rye grass (Lolium perenne) pollen allergens, Lol p I, II, and III, are associated with histocompatibility leukocyte antigen (HLA)-DR3. Rye-allergic people are often concordantly sensitive to all three of these allergens. Since earlier studies suggested that these antigens are non-cross-reactive, their immunologic relatedness by double antibody radioimmunoassay (DARIA) was studied in order to understand further the immunochemical basis for the concordant recognition of the three allergens. Direct binding DARIA studies were performed with human sera from 189 allergic subjects. Inhibition DARIA studies were carried out with 17 human sera from grass-allergic patients who were on grass immunotherapy, one goat anti-serum, and six rabbit antisera. None of the sera detected any significant degree of two-way cross-reactivity between Lol p I and II, or between Lol p I and III. However, the degree of two-way cross-reactivity between Lol p II and III exhibited by individual human and animal antisera varied between undetectable and 100%. In general, the degree of cross-reactivity between Lol p II and III was higher among human sera than among animal sera. Taken together with earlier findings that antibody responses to Lol p I, II and III are associated with HLA-HDR3, and that most Lol p II and III responders are also Lol p I responders, but not vice versa, our present results suggest the following: the HLA-DR3-encoded Ia molecule recognizes a similar immunodominant Ia recognition site (agretope) shared between Lol p I and Lol p II and/or III; in addition, Lol p I appears to contain unique Ia recognition site(s) not present in Lol p II and III. However, further epitope analyses are required to investigate these possibilities.

  2. Comparative Analysis Study of Open Source GIS in Malaysia

    NASA Astrophysics Data System (ADS)

    Rasid, Muhammad Zamir Abdul; Kamis, Naddia; Khuizham Abd Halim, Mohd

    2014-06-01

    Open source origin might appear like a major prospective change which is qualified to deliver in various industries and also competing means in developing countries. The leading purpose of this research study is to basically discover the degree of adopting Open Source Software (OSS) that is connected with Geographic Information System (GIS) application within Malaysia. It was derived based on inadequate awareness with regards to the origin ideas or even on account of techie deficiencies in the open origin instruments. This particular research has been carried out based on two significant stages; the first stage involved a survey questionnaire: to evaluate the awareness and acceptance level based on the comparison feedback regarding OSS and commercial GIS. This particular survey was conducted among three groups of candidates: government servant, university students and lecturers, as well as individual. The approaches of measuring awareness in this research were based on a comprehending signal plus a notion signal for each survey questions. These kinds of signs had been designed throughout the analysis in order to supply a measurable and also a descriptive signal to produce the final result. The second stage involved an interview session with a major organization that carries out available origin internet GIS; the Federal Department of Town and Country Planning Peninsular Malaysia (JPBD). The impact of this preliminary study was to understand the particular viewpoint of different groups of people on the available origin, and also their insufficient awareness with regards to origin ideas as well as likelihood may be significant root of adopting level connected with available origin options.

  3. An Experimental and Numerical Study of Hybrid III Dummy Response to Simulated Underbody Blast Impacts.

    PubMed

    Somasundaram, Karthik; Kalra, Anil; Sherman, Don; Begeman, Paul; Yang, King H; Cavanaugh, John M

    2017-08-16

    Anthropometric test devices (ATDs) such as Hybrid III dummy have been widely used in automotive crash tests to evaluate the risks of injury at different body regions. In recent years, researchers have started using automotive ATDs to study the high-speed vertical loading response caused by underbelly blast (UBB) impacts. This study analyzed the Hybrid III dummy responses to short-duration large magnitude vertical acceleration in a laboratory setup. Two unique test conditions were investigated using a horizontal sled system to simulate the UBB loading conditions. The biomechanical response in terms of the pelvis acceleration, chest acceleration, lumbar spine force, head accelerations and neck forces were measured. Subsequently, a series of finite element analyses (FEA) were performed to simulate the physical tests. The correlation between the Hybrid III test and numerical model was evaluated using the CORA version 3.6.1. The score for WSU FE model was 0.878 and 0.790 for loading condition 1 and 2, respectively in which 1.0 indicated a perfect correlation between the experiment and simulation response. With repetitive vertical impacts, the Hybrid III dummy pelvis showed a significant increase in the peak acceleration accompanied by rupture of the pelvis foam and flesh. The revised WSU Hybrid III model indicated high stress concentrations at the same location, providing a possible explanation for the material failure in actual Hybrid III tests.

  4. Biofilms of As(III)-oxidising bacteria: formation and activity studies for bioremediation process development.

    PubMed

    Michel, C; Jean, M; Coulon, S; Dictor, M-C; Delorme, F; Morin, D; Garrido, F

    2007-11-01

    The formation and activity of an As(III)-oxidising biofilm in a bioreactor, using pozzolana as bacterial growth support, was studied for the purpose of optimising fixed-bed bioreactors for bioremediation. After 60 days of continuous functioning with an As(III)-contaminated effluent, the active biofilm was found to be located mainly near the inflow rather than homogeneously distributed. Biofilm development by the CAsO1 bacterial consortium and by Thiomonas arsenivorans was then studied both on polystyrene microplates and on pozzolana. Extra-cellular polymeric substances (EPS) and yeast extract were found to enhance bacteria attachment, and yeast extract also appears to increase the kinetics of biofilm formation. Analysis of proteins, sugars, lipids and uronic acids indicate that sugars were the main EPS components. The specific As(III)-oxidase activity of T. arsenivorans was higher (by ninefold) for planktonic cells than for sessile ones and was induced by As(III). All the results suggest that the biofilm structure is a physical barrier decreasing As(III) access to sessile cells and thus to As(III)-oxidase activity induction. The efficiency of fixed-bed reactors for the bioremediation of arsenic-contaminated waters can be thus optimised by controlling different factors such as temperature and EPS addition and/or synthesis to increase biofilm density and activity.

  5. A Case Study of Scholars' Open and Sharing Practices

    ERIC Educational Resources Information Center

    Veletsianos, George

    2015-01-01

    Although the open scholarship movement has successfully captured the attention and interest of higher education stakeholders, researchers currently lack an understanding of the degree to which open scholarship is enacted in institutions that lack institutional support for openness. I help fill this gap in the literature by presenting a descriptive…

  6. Astrometric and Photometric Study of the Open Cluster NGC 2323

    NASA Astrophysics Data System (ADS)

    Amin, M. Y.; Elsanhoury, W. H.

    2017-06-01

    We present a study of the open cluster NGC 2323 using astrometric and photometric data. In our study we used two methods that are able to separate open cluster's stars from those that belong to the stellar background. Our results of calculations by these two methods indicate that: 1) according to the membership probability, NGC 2323 should contain 497 stars, 2) the cluster center should be at 07h 02m 48.02s and -08° 20' 17" 74, 3) the limiting radius of NGC 2323 is 2.31 ± 0.04 pc, the surface number density at this radius is 98.16 stars pc^{-2}, 4) the magnitude function has a maximum at about m_{v} = 14 mag, 5) the total mass of NGC 2323 is estimated dynamically by using astrometric data to be 890 M_{⊙}, and statistically by using photometric data to be 900 M_{⊙}, and 6) the distance and age of the cluster are found to be equal to 900 ± 100 pc, and 140 ± 20 Myr, respectively. Finally the dynamical evolution parameter τ of the cluster is about 436.2.

  7. A comparative study of internal fixation and prosthesis replacement for radial head fractures of Mason type III

    PubMed Central

    Ruan, Hong-Jiang; Liu, Jun-Jian; Zeng, Bing-fang

    2007-01-01

    Although several treatment options for radial head fractures are available, no clear solutions exist. In this study we therefore compare open reduction and internal fixation (ORIF) with bipolar radial head prosthesis replacement in treatment of radial head fractures of Mason type III. Cement stem and bipolar radial prosthesis were used to treat 12 fresh cases and two old cases of Mason type III radial head fracture. As a control group, another eight cases of radial head type III fracture were treated with ORIF with cannulated screws and Kirschner (K) wires. The 14 patients who received radial head prosthesis replacement were followed-up for 15.9 months (range 10–27 months). According to elbow functional evaluation criteria by Broberg and Morrey, we found excellent results in nine cases, good in four, and fair in one. Mean follow-up of the eight cases in the ORIF group was 14 months (range 10–21 months), with good results in one case, fair in four, and poor in three. The result was good or excellent in 92.9% of prosthesis replacement patients and in 12.5% of ORIF patients. This difference is statistically significant (P = 0.0004; Fisher’s exact test). We concluded that bipolar radial head prosthesis replacement is better than ORIF in treatment of Mason type III radial head fracture. Electronic Supplementary Material The online version of this article (doi:10.1007/s00264-007-0453-3) contains supplementary material, which is available to authorized users. PMID:17938924

  8. X-RAY AND CRYSTALLOGRAPHIC STUDIES OF PLANT VIRUS PREPARATIONS. III

    PubMed Central

    Bernal, J. D.; Fankuchen, I.

    1941-01-01

    These papers give an account of an optical and x-ray examination of preparations of plant virus substances isolated by Bawden and Pirie, in particular of those of tobacco mosaic disease. They open with a historical survey of the work, indicating the order in which new phenomena were discovered. The subsequent treatment is divided into three parts: I. Introduction and preparation of specimens. II. Modes of aggregation of virus particles. III. (1) The structure of the particles. (2) Biological implications. Part I, after an historical introduction, describes the method of preparation, from solutions of the virus, of optically oriented specimens of different concentrations. For their examination special x-ray apparatus was developed, in particular cameras working with very low angles and capable of indicating spacings up to 1000 Å. In Part III, Section 1 deals with the x-ray evidence on the internal structure of the particles. Even in solution, they have an inner regularity like that of a crystal. Virus preparations are thus in a sense doubly crystalline. Closer analysis reveals that the x-ray patterns are not directly comparable to those of a crystal as many of the reflections do not obey Bragg's law, but can be understood on the theory of gratings of limited size. The structure seems to consist of sub-units of the dimensions of approximately 11 Å cube, fitted together in a hexagonal or pseudohexagonal lattice of dimensions—a = 87 Å, c = 68 Å. Contrary to what earlier observations seemed to indicate, the particle seems to be virtually unchanged by drying and must therefore contain little water. There are marked resemblances with the structure of both crystalline and fibrous protein, but the virus structure does not belong to any of the classes hitherto studied. There are indications that the inner structure is of a simpler character than that of the molecules of crystalline proteins. Part III, Section 2 contains a comparative study of the optical and x

  9. Geothermal Exploration Case Studies on OpenEI (Presentation)

    SciTech Connect

    Young, K.; Bennett, M.; Atkins, D.

    2014-03-01

    The U.S. Geological Survey (USGS) resource assessment (Williams et al., 2008) outlined a mean 30 GWe of undiscovered hydrothermal resource in the western United States. One goal of the U.S. Department of Energy's (DOE) Geothermal Technology Office (GTO) is to accelerate the development of this undiscovered resource. DOE has focused efforts on helping industry identify hidden geothermal resources to increase geothermal capacity in the near term. Increased exploration activity will produce more prospects, more discoveries, and more readily developable resources. Detailed exploration case studies akin to those found in oil and gas (e.g. Beaumont and Foster, 1990-1992) will give developers central location for information gives models for identifying new geothermal areas, and guide efficient exploration and development of these areas. To support this effort, the National Renewable Energy Laboratory (NREL) has been working with GTO to develop a template for geothermal case studies on the Geothermal Gateway on OpenEI. In 2012, the template was developed and tested with two case studies: Raft River Geothermal Area (http://en.openei.org/wiki/Raft_River_Geothermal_Area) and Coso Geothermal Area (http://en.openei.org/wiki/Coso_Geothermal_Area). In 2013, ten additional case studies were completed, and Semantic MediaWiki features were developed to allow for more data and the direct citations of these data. These case studies are now in the process of external peer review. In 2014, NREL is working with universities and industry partners to populate additional case studies on OpenEI. The goal is to provide a large enough data set to start conducting analyses of exploration programs to identify correlations between successful exploration plans for areas with similar geologic occurrence models.

  10. Studies in Environment--Volume III: Pollution and the Municipality.

    ERIC Educational Resources Information Center

    Cooper, Pamela C.; And Others

    Recent studies have focused attention on the fact that residents of inner-city neighborhoods are subject to greater amounts of pollutants than are other neighborhoods of large cities. In this study, the premise is set forth and investigated at the metropolitan scale, seeking to discover differences of impact between the center city and its…

  11. Youth Advocacy Training Resource. Volume III. Case Studies.

    ERIC Educational Resources Information Center

    Evaluation Technologies, Inc., Arlington, VA.

    This volume presents three case studies of Teacher Corps Youth Advocacy Projects. The three projects selected represent the diversity inherent in Teacher Corps in setting, population, local education agency sites, and theoretical approach to the education of troubled youth. The focus of the study of the Arizona State University Project, which is…

  12. Doctoral Study in Rehabilitation: III. Status and Trends.

    ERIC Educational Resources Information Center

    Maki, Dennis R.; Berven, Norman L.; Peterson, David B.

    2003-01-01

    The third in a series of studies was conducted to describe doctoral programs in rehabilitation over three successive time periods. Characteristics of programs were summarized for the 1999-2000 academic year, including degrees and majors offered, admissions, curriculum, students, and faculty. As with the previous studies, considerable variability…

  13. Effects of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in grade III open tibia fractures treated with unreamed nails-A clinical and health-economic analysis.

    PubMed

    Alt, Volker; Borgman, Benny; Eicher, Alexander; Heiss, Christian; Kanakaris, Nikolaos K; Giannoudis, Peter V; Song, Fujian

    2015-11-01

    Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) is licensed in Europe for open tibia fractures treated with unreamed nails. However, there is limited data available on the specific use of rhBMP-2 in combination with unreamed nails for open tibia fractures. The intention of the current study was to evaluate the medical and health-economic effects of rhBMP-2 in Gustilo-Anderson grade III open tibia fractures treated with unreamed nails based on individual patient data from two previously published studies. Linear regression analysis was performed on raw data of 90 patients that were either treated by standard of care with soft tissue management and unreamed nailing (SOC group) (n=50) or with rhBMP-2 in addition to soft tissue management and unreamed nailing (rhBMP-2 group) (n=40). For all types of revision, a significant lower percentage of patients (27.5%) of the rhBMP-2 group had to be revised compared to 48% of the patients of the SOC group (p=0.04). When only invasive secondary interventions such as bone grafting and nail exchange were considered, there was also a statistically significant reduction in the rhBMP-2 group with a revision rate of 10.0% (4 of 40 patients) compared to the SOC group with a revision rate of 28.0% (14 of 50 patients) (p=0.01). Mean fracture healing time of 228 days in the rhBMP-2 compared to 266 days in the SOC group was not statistically significant (p=0.24). Health-economic analysis based on a societal perspective with calculation of overall treatment costs after initial surgery and including productivity losses revealed savings of €6,239 per patient for Germany and €4,752 for the UK in favour of rhBMP-2 which was mainly driven by reduction of productivity losses. In conclusion, rhBMP-2 reduces secondary interventions in patients with grade III open tibia fractures treated with an unreamed nail and its use leads to financial savings for Germany and the UK from a societal perspective. Copyright © 2015 Elsevier Ltd. All

  14. A study of skin diseases in dogs and cats. III. III. Microflora of the skin of dogs with chronic eczema.

    PubMed

    Kristensen, S; Krogh, H V

    1978-01-01

    The microflora of the skin was studied in 10 dogs with chronic eczema without clinical signs of secondary infection (Table I). The skin surface was swabbed at 7 different sites, making a total of 70 swabs, 25 of which were taken from visibly inflamed areas and 45 from apparently unaffected skin (Table II). Staph. aureus, Staph. epidermidis, micrococci, alpha-hemolytic streptococci, and Acinetobacter spp. were found consistently. Ten different Gram-negative bacteria, 3 different Gram-positive bacteria, and 2 yeasts were found to occur sporadically (Table III). Compared to a group of 10 healthy dogs a more prolific growth of aerobic microorganisms, a greater number of sites carrying Staph. aureus, and a higher recovery of Gram-negative transients were found in dogs with eczema (Table IV--VII). Within the group of dogs with eczema the growth of Staph. aureus was significantly heavier from eczematous skin areas than from clinically normal skin (Table VIII). In dogs with non-infective dermatitides the colonization of the skin by potentially pathogenic microorganisms may have to be considered in the clinical handling of these diseases.

  15. La(III)-hydrogen peroxide cooperativity in phosphate diester cleavage. A mechanistic study

    SciTech Connect

    Takasaki, B.K.; Chin, J.

    1995-08-23

    La(III), Pr(III), Nd(III), and Eu(III) (2 mM) can each combine with hydrogen peroxide to provide close to 9 orders of magnitude rate acceleration for hydrolyzing BNPP (bis(p-nitrophenyl) phosphate) at pH 7 and 25{degree}C. The rate of the reaction is second order each in [(III)] and [H{sub 2}O{sub 2}], indicating that the active core 4 of the catalyst consists of two La(III) with two peroxides. The equilibrium constant for binding of BNPP to 4 (K{sub 1} = (1.3 {+-} 0.1) x 10{sup +3} M{sup -1}) and the rate constant for hydrolysis of the bound phosphate (k{sub 2} = (1.8 {+-} 0.1) x 10{sup -7} 5{sup -1}) have been determined. {sup 18}O labeling studies reveal that the peroxide is a nucleophilic catalyst in cleaving the diester. 17 refs., 5 figs., 1 tab.

  16. Open access and openly accessible: a study of scientific publications shared via the internet

    PubMed Central

    Wren, Jonathan D

    2005-01-01

    Objectives To determine how often reprints of scientific publications are shared online, whether journal readership level is a predictor, how the amount of file sharing changes with the age of the article, and to what degree open access publications are shared on non-journal websites. Design The internet was searched using an application programming interface to Google, a popular and freely available search engine. Main outcome measures The proportion of reprints of journal articles published between 1994 and 2004 from within 13 subscription based and four open access journals that could be located online at non-journal websites. Results The probability that an article could be found online at a non-journal website correlated with the journal impact factor and the time since initial publication. Papers from higher impact journals and more recent articles were more likely to be located. On average, for the high impact journal articles published in 2003, over a third could be located at non-journal websites. Similar trends were observed for the delayed or full open access publications. Conclusions Decentralised sharing of scientific reprints through the internet creates a degree of de facto open access that, though highly incomplete in its coverage, is none the less biased towards publications of higher popular demand. PMID:15827063

  17. Open access and openly accessible: a study of scientific publications shared via the internet.

    PubMed

    Wren, Jonathan D

    2005-05-14

    To determine how often reprints of scientific publications are shared online, whether journal readership level is a predictor, how the amount of file sharing changes with the age of the article, and to what degree open access publications are shared on non-journal websites. The internet was searched using an application programming interface to Google, a popular and freely available search engine. The proportion of reprints of journal articles published between 1994 and 2004 from within 13 subscription based and four open access journals that could be located online at non-journal websites. The probability that an article could be found online at a non-journal website correlated with the journal impact factor and the time since initial publication. Papers from higher impact journals and more recent articles were more likely to be located. On average, for the high impact journal articles published in 2003, over a third could be located at non-journal websites. Similar trends were observed for the delayed or full open access publications. Decentralised sharing of scientific reprints through the internet creates a degree of de facto open access that, though highly incomplete in its coverage, is none the less biased towards publications of higher popular demand.

  18. Open-Source Software in Computational Research: A Case Study

    DOE PAGES

    Syamlal, Madhava; O'Brien, Thomas J.; Benyahia, Sofiane; ...

    2008-01-01

    A case study of open-source (OS) development of the computational research software MFIX, used for multiphase computational fluid dynamics simulations, is presented here. The verification and validation steps required for constructing modern computational software and the advantages of OS development in those steps are discussed. The infrastructure used for enabling the OS development of MFIX is described. The impact of OS development on computational research and education in gas-solids flow, as well as the dissemination of information to other areas such as geophysical and volcanology research, is demonstrated. This study shows that the advantages of OS development were realized inmore » the case of MFIX: verification by many users, which enhances software quality; the use of software as a means for accumulating and exchanging information; the facilitation of peer review of the results of computational research.« less

  19. Open-Source Software in Computational Research: A Case Study

    SciTech Connect

    Syamlal, Madhava; O'Brien, Thomas J.; Benyahia, Sofiane; Gel, Aytekin; Pannala, Sreekanth

    2008-01-01

    A case study of open-source (OS) development of the computational research software MFIX, used for multiphase computational fluid dynamics simulations, is presented here. The verification and validation steps required for constructing modern computational software and the advantages of OS development in those steps are discussed. The infrastructure used for enabling the OS development of MFIX is described. The impact of OS development on computational research and education in gas-solids flow, as well as the dissemination of information to other areas such as geophysical and volcanology research, is demonstrated. This study shows that the advantages of OS development were realized in the case of MFIX: verification by many users, which enhances software quality; the use of software as a means for accumulating and exchanging information; the facilitation of peer review of the results of computational research.

  20. Open -source software in computational research: A case study

    SciTech Connect

    Syamlal, M.; O'Brien, T.; Benyahia, S.; Gel, A.; Pannala, S.

    2008-01-01

    A case study of open-source (OS) development of the computational research software MFIX, used for multiphase computational fluid dynamics simulations, is presented here. The verification and validation steps required for constructing modern computational software and the advantages of OS development in those steps are discussed. The infrastructure used for enabling the OS development of MFIX is described. The impact of OS development on computational research and education in gas-solids flow, as well as the dissemination of information to other areas such as geophysical and volcanology research, is demonstrated. This study shows that the advantages of OS development were realized in the case of MFIX: verification by many users, which enhances software quality; the use of software as a means for accumulating and exchanging information; the facilitation of peer review of the results of computational research.

  1. Theoretical study of metal-ligand interaction in Sm(III), Eu(III), and Tb(III) complexes of coumarin-3-carboxylic acid in the gas phase and solution.

    PubMed

    Georgieva, Ivelina; Trendafilova, Natasha; Aquino, Adélia J A; Lischka, Hans

    2007-12-10

    The interaction of lanthanide(III) cations (Ln(III) = Sm(III), Eu(III), and Tb(III)) with the deprotonated form of the coumarin-3-carboxylic acid (cca-) has been investigated by density functional theory (DFT/B3LYP) and confirmed by reference MP2 and CCSD(T) computations. Solvent effects on the geometries and stabilities of the Ln(III) complexes were computed using a combination of water clusters and a continuum solvation model. The following two series of systems were considered: (i) Ln(cca)2+, Ln(cca)2+, Ln(cca)3 and (ii) Ln(cca)(H2O)2Cl2, Ln(cca)2(H2O)2Cl, Ln(cca)3. The strength and character of the Ln(III)-cca- bidentate bonding were characterized by calculated Ln-O bond lengths, binding energies, ligand deformation energies, energy partitioning analysis, sigma-donation contributions, and natural population analyses. The energy decomposition calculations predicted predominant electrostatic interaction terms to the Ln-cca bonding (ionic character) and showed variations of the orbital interaction term (covalent contributions) for the Ln-cca complexes studied. Electron distribution analysis suggested that the covalent contribution comes mainly from the interaction with the carboxylate moiety of cca-.

  2. Integrated spectral study of small angular diameter galactic open clusters

    NASA Astrophysics Data System (ADS)

    Clariá, J. J.; Ahumada, A. V.; Bica, E.; Pavani, D. B.; Parisi, M. C.

    2017-10-01

    This paper presents flux-calibrated integrated spectra obtained at Complejo Astronómico El Leoncito (CASLEO, Argentina) for a sample of 9 Galactic open clusters of small angular diameter. The spectra cover the optical range (3800-6800 Å), with a resolution of ∼14 Å. With one exception (Ruprecht 158), the selected clusters are projected into the fourth Galactic quadrant (282o < l < 345o) near the Galactic plane (∣b∣ ≤ 9o). We performed simultaneous estimates of foreground interstellar reddening and age by comparing the continuum distribution and line strenghts of the cluster spectra with those of template cluster spectra with known parameters. We thus provide spectroscopic information independent from that derived through color-magnitude diagram studies. We found three clusters (Collinder 249, NGC 4463 and Ruprecht 122) younger than ∼40 Myr, four moderately young ones (BH 92, Harvard 5, Hogg 14 and Pismis 23) with ages within 200-400 Myr, and two intermediate-age ones (Ruprecht 158 and ESO 065-SC07) with ages within 1.0-2.2 Gyr. The derived foreground E(B - V) color excesses vary from around 0.0 in Ruprecht 158 to ∼1.1 in Pismis 23. In general terms, the results obtained show good agreement with previous photometric results. In Ruprecht 158 and BH 92, however, some differences are found between the parameters here obtained and previous values in the literature. Individual spectra of some comparatively bright stars located in the fields of 5 out of the 9 clusters here studied, allowed us to evaluate their membership status. The current cluster sample complements that of 46 open clusters previously studied by our group in an effort to gather a spectral library with several clusters per age bin. The cluster spectral library that we have been building is an important tool to tie studies of resolved and unresolved stellar content.

  3. (Defect studies in III-V thin film semiconductors)

    SciTech Connect

    Not Available

    1991-01-01

    Our primary research objective in 90/91 has been to continue studying misfit dislocation confinement by patterning substrates into mesas before the epitaxial growth of strained layers. This report presents progress for many of the areas of our research. (JL)

  4. Does a laparoscopic approach attenuate the body weight loss and lean body mass loss observed in open distal gastrectomy for gastric cancer? a single-institution exploratory analysis of the JCOG 0912 phase III trial.

    PubMed

    Aoyama, Toru; Sato, Tsutomu; Hayashi, Tsutomu; Yamada, Takanobu; Cho, Haruhiko; Ogata, Takashi; Oba, Koji; Yoshikawa, Takaki

    2017-06-16

    Laparoscopy-assisted distal gastrectomy (LADG) for gastric cancer may prevent the loss of body weight and lean body mass resulting from reduced surgical stress in comparison to open distal gastrectomy (ODG). A multicenter phase III trial conducted by the Japan Clinical Oncology Group (JCOG0912 trial) was performed to confirm the non-inferiority of LADG to ODG for stage I gastric cancer in terms of relapse-free survival. This study was performed as a single-institution exploratory analysis using the data of the patients from our hospital who were enrolled in the JCOG0912 phase III trial. Body weight and lean body mass were evaluated using a bioelectrical impedance analyzer within 1 week before and at 1 week, 1 month, and 3 months after surgery. One-hundred six patients were randomized to undergo ODG (54 patients) or LADG (51 patients). Body weight loss at 1 week, 1 month, and 3 months was -3.0%, -4.9%, and -5.4%, respectively, in the ODG group and -2.7%, -4.3%, and -5.7%, respectively, in the LADG group; the differences were not statistically significant (p = 0.330, 0.166, and 0.656, respectively). Lean body mass loss at 1 week, 1 month, and 3 months was -2.8%, -4.1%, and -2.3%, respectively, in the ODG group and -2.7%, -2.9%, and -3.0%, respectively, in the LADG group; the differences were not statistically significant (p = 0.610, 0.413, and 0.925, respectively). The laparoscopic approach did not attenuate the loss of body weight and lean body mass in comparison to patients who underwent open distal gastrectomy for gastric cancer.

  5. Alcohol consumption and mortality. III. Studies of female populations.

    PubMed

    Fillmore, K M; Golding, J M; Graves, K L; Kniep, S; Leino, E V; Romelsjö, A; Shoemaker, C; Ager, C R; Allebeck, P; Ferrer, H P

    1998-02-01

    This is the third of a set of three papers evaluating drinking status and mortality risk. Analysis of three general population surveys of women evaluated all-cause mortality rates by drinking pattern. Raw data from three studies of adult women were evaluated. Logistic regression models controlled for confounding characteristics. Meta-analysis combined study results. Drinking pattern was alternatively defined by quantity, frequency and volume of drinking. Final models included drinking pattern (including long-term abstainers and former drinkers) as well as age and other confounding variables. Models also evaluated interactions of age and, respectively, long-term abstinence and former drinking. In models in which age was controlled, odds of death for long-term abstainers and former drinkers (defined by volume or quantity) were greater than those for light drinkers; odds of death for moderate and heavy drinkers (defined by quantity) were greater than those for light drinkers. When other psychosocial attributes were controlled, odds of death were similar for abstainers and light drinkers. When other psychosocial attributes were controlled, odds of death for heavy drinkers (defined by volume and quantity) were greater than those for light drinkers. When interactions of age and the two forms of abstinence were introduced, one study showed a significant effect of age and former drinking. Results were consistent with the hypothesis that characteristics of abstainers other than their non-use of alcohol may account for their higher mortality risk. With the exception of former drinkers compared to light drinkers, when interactions were introduced into models (for measures of quantity and frequency) findings were homogeneous across studies, lending generalizability to results.

  6. Novel optical study and application on iii-nitrides

    NASA Astrophysics Data System (ADS)

    Sun, Guan

    GaN and its heterostuctures have been intensively studied for wide applications. For example, InGaN/GaN quantum wells (QWs) have been used as active materials for light emitting diodes (LEDs) and laser diodes (LDs) from blue to green region while GaN/AlGaN QWs have been used for ultraviolet region. Meanwhile, nitrides are also very important materials for power electronic devices since such materials hold various advantage over competing semiconductor materials such as Si, GaAs, etc. Due to the above reasons, we believe GaN and its heterostructures will play crucial role for optics and electronics devices as silicon does for electronics. Thus, it is worthwhile to explore possibility of achieving different kinds of newapplications on GaN. This dissertation is focused on optical study on GaN based materials, including GaN thin film, InGaN/GaN QWs, InGaN dot-in-a-wire nanostructures, GaN/AlN QWs, etc. More specifically, in Chapter 2, we report efficient broadband terahertz (THz) generated in InGaN/GaN heterostructures due to spontaneous dipole radiation utilizing the strong internal field. Considering the normalized power, InGaN/GaN heterostructure is one of the most efficient materials for broadband THz generation. The correlated behavior between THz and photoluminescence (PL) has also been discussed. In Chapter 3, we present the study of PL upconversion from a free standing GaN and the mechanism has been attributed to phonon-assisted anti-Stokes photoluminescence (ASPL) if photon energy of pump laser is in the tail of absorption edge. The potential of laser cooling based on such phenomena has been explored. In Chapter 4, we have present detailed PL studies on different kind of nitrides materials including InGaN/GaN QWs, GaN/AlN QWs, GaN thin film and BN powders. In Chapter 5, we explore the possibility of nonlinear generation on GaN. A GaN/AlGaN multilayer waveguide has been designed to achieve transverse parametric conversion. The objective of this dissertation is

  7. Value of routine staging imaging studies for patients with stage III breast cancer.

    PubMed

    Piatek, Caroline I; Ji, Lingyun; Kaur, Chandan; Russell, Christy A; Tripathy, Debu; Church, Terry; Sposto, Richard; Sener, Stephen F; Garcia, Agustin A

    2016-12-01

    Routine staging imaging studies (RSIS) are optional in stage III breast cancer (BC). The impact of RSIS on treatment decisions and patient outcomes has not been extensively studied. The goal of this study was to determine whether RSIS in stage III BC affected treatment or patient outcomes. Stage III BC patients from 2000 to 2010 were retrospectively identified. RSIS results and treatment plan in response to RSIS results were recorded. Univariate and multivariate Cox proportional hazards regression models with time-dependent covariates were used to assess associations between RSIS use and recurrence-free survival (RFS). Of 420 patients, 362 (86.2%) received RSIS. RSIS were negative in 264 (72.9%), indeterminate in 77 (18.3%), and positive in 21 patients (5.0%) for metastatic disease. Treatment was altered in 21 (5.8%) patients based on RSIS results (20 with metastatic disease, 1 with indeterminate disease). There was no difference in RFS with RSIS use on multivariate analysis (hazard ratio 1.3; 95% confidence interval 0.73-2.5, P = 0.32). Most stage III BC patients underwent RSIS, but RSIS results infrequently affected treatment decisions. There was no significant difference in RFS with RSIS use. RSIS to identify metastatic disease for stage III BC has limited value. J. Surg. Oncol. 2016;114:917-921. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  8. III. Electrophysiological studies of face processing in Williams syndrome.

    PubMed

    Mills, D L; Alvarez, T D; St George, M; Appelbaum, L G; Bellugi, U; Neville, H

    2000-01-01

    Williams Syndrome (WMS) is a genetically based disorder characterized by pronounced variability in performance across different domains of cognitive functioning. This study examined brain activity linked to face-processing abilities, which are typically spared in individuals with WMS. Subjects watched photographic pairs of upright or inverted faces and indicated if the second face matched or did not match the first face. Results from a previous study with normal adults showed dramatic differences in the timing and distribution of ERP effects linked to recognition of upright and inverted faces. In normal adults, upright faces elicited ERP differences to matched vs. mismatched faces at approximately 320 msec (N320) after the onset of the second stimulus. This "N320" effect was largest over anterior regions of the right hemisphere. In contrast, the mismatch/match effect for inverted faces consisted of a large positive component between 400 and 1000 msec (P500) that was largest over parietal regions and was symmetrical. In contrast to normal adults, WMS subjects showed an N320-mismatch effect for both upright and inverted faces. Additionally, the WMS subjects did not display the N320 right-hemisphere asymmetry observed in the normal adults. WMS subjects also displayed an abnormally small negativity at 100 msec (N100) and an abnormally large negativity at 200 msec (N200) to both upright and inverted faces. This ERP pattern was observed in all subjects with WMS but was not observed in the normal controls. These results may be linked to increased attention to faces in subjects with WMS and might be specific to the disorder. These results were consistent with our ERP studies of language processing in WMS, which suggested abnormal cerebral specialization for spared cognitive functions in individuals with WMS.

  9. Experimental study of thermomagnetic energy conversion by dysprosium: III

    SciTech Connect

    Petrenko, I.S.; Finkel', V.A.

    1983-06-01

    The influence of the structural state of dysprosium (the working medium in a thermomagnetic generator) on its magnetic properties is studied in a neighborhood of a ferromagnetic arrow-right-left antiferromagnetic phase transition of the first kind. It is shown that a single crystal oriented with its easy magnetization axis parallel to the magnetic field gives the most efficient energy conversion. Isothermal magnetization at 90.2 K is irreversible regardless of the structure of the dysprosium because of the temperature hyteresis of the phase transition. The boundaries are determined for the regions in which the ferro- and antiferromagnetic states are stable during temperature cycling.

  10. Lanthanide(III) complexes of some natural siderophores: a thermodynamic, kinetic and relaxometric study.

    PubMed

    Tircsó, Gyula; Garda, Zoltán; Kálmán, Ferenc K; Baranyai, Zsolt; Pócsi, István; Balla, György; Tóth, Imre

    2013-10-01

    Stability constants of the complexes formed between the natural trihydroxamic acids desferrioxamine B (DFB) and desferricoprogen (DFC) with Nd(III), Gd(III) and Yb(III) ions were determined using pH-potentiometry. The equilibrium in these systems can be described by models containing mononuclear protonated (Ln(HL), Ln(H2L) and Ln(H3L)), deprotonated (LnL) and ternary hydroxo Ln(H-1L) complexes, but for both ligands dinuclear complexes of low stability were also detected. The stability constants for the Ln(HDFB)(+) complexes are 11.95 (Nd(III)), 13.16 (Gd(III)) and 14.67 (Yb(III)), while these values of the Ln(DFC) complexes are considerably higher (14.42 (Nd(III)), 15.14 (Gd(III)) and 16.49 (Yb(III))). The stability constants of the complexes of DFB and DFC are much lower than those of the Ln(L)3 complexes formed with some aromatic hydroxamic acids indicating that the relatively long spacer between the hydroxamic acid moieties in DFB and DFC is unfavorable for Ln(III) complexation. The relaxometric study conducted for the Gd(HDFB)(+) species revealed an interesting pH dependence of the relaxivity associated with a large hydration number (bishydrated complex) and fast water exchange (kex=(29.9±0.4)×10(6)s(-1)), which would be favorable for CA use. However the dissociation of Gd(HDFB)(+) is fairly fast (<2ms) under all conditions employed in the present work thus the kinetically labile Gd(HDFB)(+) is not suitable for in vivo CA applications. Some low stability ternary complexes were also detected with K(Gd(HDFB)(HCO3))=17.5±1.9 and K(Gd(HDFB)(Lactate))=8.4±3.2 but in the presence of citrate and phosphate ions the Gd(HDFB)(+) complex was found to dissociate.

  11. Density functional theory studies of actinide(III) motexafins (An-Motex2+, An = Ac, Cm, Lr). Structure, stability, and comparison with lanthanide(III) motexafins.

    PubMed

    Cao, Xiaoyan; Li, Quansong; Moritz, Anna; Xie, Zhizhong; Dolg, Michael; Chen, Xuebo; Fang, Weihai

    2006-04-17

    Newly developed relativistic energy-consistent 5f-in-core actinide pseudopotentials and corresponding (7s6p5d1f)/[5s4p3d1f] basis sets in the segmented contraction scheme, combined with density functional theory methods, have been used to study the molecular structure and chemical properties of selected actinide(III) motexafins (An-Motex2+, An = Ac, Cm, Lr). Structure and stability are discussed, and a comparison to the lanthanide(III) motexafins (Ln-Motex2+, Ln = La, Gd, Lu) is made. The actinide element is found to reside above the mean N5 motexafin plane, and the larger the cation, the greater the observed out-of-plane displacement. It is concluded that the actinium(III), curium(III), and lawrencium(III) cations are tightly bound to the macrocyclic skeleton, yielding stable structures. However, the calculated metal-ligand gas-phase binding energy for An-Motex2+ is about 1-2 eV lower than that of Ln-Motex2+, implying a lower stability of An-Motex2+ compared to Ln-Motex2+. Results including solvent effects imply that Ac-Motex2+ is the most stable complex in aqueous solution and should be the best candidate for experimentalists to get stable actinide(III) motexafin complexes.

  12. Sorption Studies and Characterization of As (III) Adsorption over Developed Iron-Biochar Composites from Water.

    NASA Astrophysics Data System (ADS)

    Singh, P.; Mohan, D.

    2016-12-01

    Problem related to arsenic occurrence in groundwater has caused severe threat to human health in worldwide. Thus there is an increasing demand to find the chemistry and plausible mechanism of arsenic adsorption while remediating it from water. In present study iron-biochar composites are synthesised using agricultural waste materials. The rice husk iron-biochar composite (RIBC) and wheat husk iron-biochar composite (WIBC) were characterised and utilised for As (III) remediation from aqueous solution. The rice husk (RIBC) and wheat husk (WIBC) iron biochar composites were characterised. XPS, FT-IR, and XRD, were studied to analyse their elemental composition and functional group identification. While SEM, TEM, SEM-EDX were conducted to study their surface chemistry, mineralogy, porosity and crystallinity etc. Batch sorption studies were conducted for both rice husk (RIBC) and wheat husk (WIBC) iron-biochar composites to find sorption efficiency. Maximum As (III) adsorption was achieved in pH range 6-8 for both iron-biochar composites. Kinetic studies were conducted to establish the mechanism of As (III) adsorption at different dose and time. Optimum dose of 2g/L and 1g/L were reported for rice husk (RIBC) and wheat husk (WIBC) iron-biochar composites respectively. Electrostatic forces developed between arsenites and iron hydroxyl surface developed over the surface may have caused the removal of As (III). Significant amount of oxygen containing groups have been revealed through studies. Higher As (III) adsorption capacities were obtained for both iron-biochar composites to measure the amount of surface sites. Furthermore, various adsorption models are used to find the monolayer adsorption capacity. These findings suggest that developed iron-biochar composites may be used to remediate As (III) from contaminated water.

  13. National police suicide estimates: web surveillance study III.

    PubMed

    O'Hara, Andrew F; Violanti, John M; Levenson, Richard L; Clark, Ronald G

    2013-01-01

    The present study is the third in a series of web surveillance of police suicides (prior analyses conducted in 2008 and 2009). In this age of world web communications, a police suicide in even the smallest and most remote community is generally transmitted nationally and through police websites, forums, and blogs. 55,000 police suicide specific web articles were reviewed over the entire year 2012 data was then compared with 2008 and 2009 police suicide data. There were 141 police suicides in 2008. Suicides declined from 143 in 2009 to 126 in 2012 (an 11.9% decrease). Across the three time periods, male and female suicides appeared to occur at a similar rate, averaging 92% and 6% respectively. In 2012, (1) suicides appeared to cluster more in the 40-44 year age group more than in previous years among officers of lower rank; (2) an increase in suicide was seen among officers with 15-19 years of service; (3) gunshots remained the most prevalent means of suicide across all three years (91.5%), and (4) personal problems appeared to be prevalent (83%) with work associated legal problems ranking second (13%). Approximately 11% of suicides were military veterans. California (n = 10) and New York (n = 12) had the highest police suicide rates. Four murder-suicides were noted over the entire year. Suggestions for suicide preventive policies, improving police mental health, and future research are discussed.

  14. Revisiting the harem conspiracy and death of Ramesses III: anthropological, forensic, radiological, and genetic study.

    PubMed

    Hawass, Zahi; Ismail, Somaia; Selim, Ashraf; Saleem, Sahar N; Fathalla, Dina; Wasef, Sally; Gad, Ahmed Z; Saad, Rama; Fares, Suzan; Amer, Hany; Gostner, Paul; Gad, Yehia Z; Pusch, Carsten M; Zink, Albert R

    2012-12-14

    To investigate the true character of the harem conspiracy described in the Judicial Papyrus of Turin and determine whether Ramesses III was indeed killed. Anthropological, forensic, radiological, and genetic study of the mummies of Ramesses III and unknown man E, found together and taken from the 20th dynasty of ancient Egypt (circa 1190-1070 BC). Computed tomography scans revealed a deep cut in Ramesses III's throat, probably made by a sharp knife. During the mummification process, a Horus eye amulet was inserted in the wound for healing purposes, and the neck was covered by a collar of thick linen layers. Forensic examination of unknown man E showed compressed skin folds around his neck and a thoracic inflation. Unknown man E also had an unusual mummification procedure. According to genetic analyses, both mummies had identical haplotypes of the Y chromosome and a common male lineage. This study suggests that Ramesses III was murdered during the harem conspiracy by the cutting of his throat. Unknown man E is a possible candidate as Ramesses III's son Pentawere.

  15. Synthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl Ligand

    PubMed Central

    Debnath, Anamika; Hussain, Firasat; Masram, Dhanraj T.

    2014-01-01

    A novel slightly distorted octahedral complex of Cr(III) of norfloxacin (Nor) with the formula [CrIII(Nor)(Bipy)Cl2]Cl·2CH3OH has been synthesized hydrothermally in the presence of a N-containing heterocyclic compound 2,2′-bipyridyl (Bipy). The complex was characterized with FT-IR, elemental analysis, UV-visible spectroscopy, and X-ray crystallography. Spectral studies suggest that the Nor acts as a deprotonated bidentate ligand. Thermal studies were also carried out. The synthesised complex was screened against four fungi Pythium aphanidermatum (PA), Sclerotinia rolfsii (SR), Rhizoctonia solani (RS), and Rhizoctonia bataticola (RB). PMID:25276111

  16. STUDIES OF THE DIFFUSE INTERSTELLAR BANDS. III. HD 183143

    SciTech Connect

    Hobbs, L. M.; Thorburn, J. A.; York, D. G.; Bishof, M.; Oka, T.; Snow, T. P.; Friedman, S. D.; McCall, B. J.; Rachford, B.; Sonnentrucker, P.; Welty, D. E.

    2009-11-01

    Echelle spectra of HD 183143 [B7Iae, E(B - V) = 1.27] were obtained on three nights, at a resolving power R = 38,000 and with a signal-to-noise ratio approx 1000 at 6400 A in the final, combined spectrum. A catalog is presented of 414 diffuse interstellar bands (DIBs) measured between 3900 and 8100 A in this spectrum. The central wavelengths, the widths (FWHM), and the equivalent widths of nearly all of the bands are tabulated, along with the minimum uncertainties in the latter. Among the 414 bands, 135 (or 33%) were not reported in four previous, modern surveys of the DIBs in the spectra of various stars, including HD 183143. The principal result of this study is that the great majority of the bands in the catalog are very weak and fairly narrow. Typical equivalent widths amount to a few mA, and the bandwidths (FWHM) are most often near 0.7 A. No preferred wavenumber spacings among the 414 bands are identified which could provide clues to the identities of the large molecules thought to cause the DIBs. At generally comparable detection limits in both spectra, the population of DIBs observed toward HD 183143 is systematically redder, broader, and stronger than that seen toward HD 204827 (Paper II). In addition, interstellar lines of C{sub 2} molecules have not been detected toward HD 183143, while a very high value of N(C{sub 2})/E(B - V) is observed toward HD 204827. Therefore, either the abundances of the large molecules presumed to give rise to the DIBs, or the physical conditions in the absorbing clouds, or both, must differ significantly between the two cases.

  17. Solvent extraction studies of lanthanum(III) and neodymium(III) with ionizable macrocyclic ligands and thenoyltrifluoroacetone

    SciTech Connect

    Manchanda, V.K.; Chang, C.A.

    1986-09-01

    Extraction behavior of La(III) and Nd(III) has been investigated by using thenoyltrifluoroacetone (TTA) as extractant in the presence of 1,7-diaza-4,10,13-trioxacyclopentadecane-N,N'-diacetic acid (DAPDA) and 1,10-diaza-4,7,13,16-tetraoxacyclooctadecane-N,N'-diacetic acid (DACDA) as macrocyclic ionophores. DAPDA and DACDA were chosen in this work in view of their unique complexation toward lanthanides. Ultraviolet spectra were adduced for the formation of ternary complex La(DAPDA)TTA in the aqueous phase. It was observed that Ln(TTA)/sub 3/ is the dominating species extracted at pH less than or equal to 5.0 and Ln(DAPDA/DACDA)TTA is the dominating species at pH approx. 7.5. Extraction of ternary complex of La(III) was found to be greater in the case of DAPDA and smaller in the case of DACDA as compared to the extraction of the corresponding ternary complex of Nd(III). By use of the stoichiometric concentration of DAPDA/DACDA and following distribution as a function of pH, lanthanide extraction maxima were observed at pH 7.5-8.0. Finally, the analytical significance of the work is discussed.

  18. Probing the Natural World, Level III, Teacher's Edition: Winds and Weather. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on weather, its measurement and prediction. Optional excursions are given for students who wish to study a topic in greater depth on an individualized basis. An introduction describes the…

  19. Selected Findings from Phase III-B. BTES. Beginning Teacher Evaluation Study. Supplement. Preliminary Version.

    ERIC Educational Resources Information Center

    Fisher, Charles W.; And Others

    This series of six papers concerning the Beginning Teacher Evaluation Study (BTES) starts with Teaching Behaviors, Academic Learning Time and Student Achievement: An Overview of Phase III-B of the Beginning Teacher Evaluation Study by the project director, Charles Fisher. As an introduction, it describes a model of classroom instruction based on…

  20. Probing the Natural World, Level III, Teacher's Edition: Well-Being. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on hazards to the body from drug use. Activities are given that relate to the topic. Optional excursions are suggested for students who wish to study an area in greater depth. An…

  1. Probing the Natural World, Level III, Teacher's Edition: Environmental Science. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit and its activities focuses on environmental pollution and hazards. Optional excursions are suggested for students who wish to study an area in greater depth. An introduction describes the problem…

  2. Probing the Natural World, Level III, Teacher's Edition: Crusty Problems. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on processes that shape the earth. Optional excursions, in addition to the activities, are suggested for students who wish to study an area in greater depth on an individualized basis. An…

  3. Experimental and numerical study of open-air active cooling

    NASA Astrophysics Data System (ADS)

    Al-Fifi, Salman Amsari

    The topic of my thesis is Experimental and Numerical Study of Open Air Active Cooling. The present research is intended to investigate experimentally and Numerically the effectiveness of cooling large open areas like stadiums, shopping malls, national gardens, amusement parks, zoos, transportation facilities and government facilities or even in buildings outdoor gardens and patios. Our cooling systems are simple cooling fans with different diameters and a mist system. This type of cooling systems has been chosen among the others to guarantee less energy consumption, which will make it the most favorable and applicable for cooling such places mentioned above. In the experiments, the main focus is to study the temperature domain as a function of different fan diameters aerodynamically similar in different heights till we come up with an empirical relationship that can determine the temperature domain for different fan diameters and for different heights of these fans. The experimental part has two stages. The first stage is devoted to investigate the maximum range of airspeed and profile for three different fan diameters and for different heights without mist, while the second stage is devoted to investigate the maximum range of temperature and profile for the three different diameter fans and for different heights with mist. The computational study is devoted to built an experimentally verified mathematical model to be used in the design and optimization of water mist cooling systems, and to compare the mathematical results to the experimental results and to get an insight of how to apply such evaporative mist cooling for different places for different conditions. In this study, numerical solution is presented based on experimental conditions, such dry bulb temperature, wet bulb temperature, relative humidity, operating pressure and fan airspeed. In the computational study, all experimental conditions are kept the same for the three fans except the fan airspeed

  4. The structure of the hydrated gallium(III), indium(III), and chromium(III) ions in aqueous solution. A large angle X-ray scattering and EXAFS study

    SciTech Connect

    Lindqvist-Reis, P.; Pattanaik, S.; Sandstroem, M.; Munoz-Paez, A.; Diaz-Moreno, S.; Persson, I.

    1998-12-28

    The structure of the hydrated gallium(III), indium(III), and chromium(III) ions has been determined in aqueous perchlorate and nitrate solutions by means of the large-angle X-ray scattering (LAXS) and extended X-ray absorption fine structure (EXAFS) techniques. The EXAFS studies have been performed over a wide concentration range, 0.005--1.0 mol/dm{sup 3} (2.6 mol/dm{sup 3} for chromium(III)), while the LAXS studies are restricted to concentrated solutions, ca. 1.5 mol/dm{sup 3}. All three metal ions were found to coordinate six water molecules, each of which are hydrogen bonded to two water molecules in a second hydration sphere. Analyses of the Ga, In, and Cr K-edge EXAFS data of the aqueous perchlorate and nitrate solutions showed no influence on the first shell M{single_bond}O distance by a change of concentration or anion. The minor contribution from the second sphere M{hor_ellipsis}O distance is obscured by multiple scattering within the tightly bonded first shell. EXAFS data for the alum salts CsM(SO{sub 4}){sub 2}{center_dot}12H{sub 2}O, M = Ga or In, showed the M-O bond length of the hexahydrated gallium(III) and indium(III) ions to be 1.957(2) and 2.122(2) {angstrom}, respectively.

  5. Open Source Course Management Systems: A Case Study

    ERIC Educational Resources Information Center

    Remy, Eric

    2005-01-01

    In Fall 2003, Randolph-Macon Woman's College rolled out Claroline, an Open Source course management system for all the classes on campus. This document will cover some background on both Open Source in general and course management systems in specific, discuss technical challenges in the introduction and integration of the system and give some…

  6. Synthesis, spectral and electrochemical studies of binuclear Ru(III) complexes containing dithiosemicarbazone ligand.

    PubMed

    Kanchana Devi, A; Ramesh, R

    2014-01-03

    Synthesis of several new octahedral binuclear ruthenium(III) complexes of the general composition [(EPh3)2(X)Ru-L-Ru(X)(EPh3)2] containing benzene dithiosemicarbazone ligands (where E=P or As; X=Cl or Br; L=binucleating ligands) is presented. All the complexes have been fully characterized by elemental analysis, FT-IR, UV-vis and EPR spectroscopy together with magnetic susceptibility measurements. IR study shows that the dithiosemicarbazone ligands behave as dianionic tridentate ligands coordinating through the oxygen atom of the deprotonated phenolic group, nitrogen atom of the azomethine group and thiolate sulphur. In DMF solution, all the complexes exhibit intense d-d transition and ligand-to-metal charge transfer (LMCT) transition in the visible region. The magnetic moment values of the complexes are in the range 1.78-1.82 BM, which reveals the presence of one unpaired electron on each metal ion. The EPR spectra of the liquid samples at LNT show the presence of three different 'g' values (gx≠gy≠gz) indicate a rhombic distortion around the ruthenium ion. All the complexes exhibit two quasi-reversible one electron oxidation responses (Ru(III)-Ru(III)/Ru(III)-Ru(IV); Ru(III)-Ru(IV)/Ru(IV)-Ru(IV)) within the E1/2 range of 0.61-0.74 V and 0.93-0.98 V respectively, versus Ag/AgCl.

  7. Rock Fracture Toughness Study Under Mixed Mode I/III Loading

    NASA Astrophysics Data System (ADS)

    Aliha, M. R. M.; Bahmani, A.

    2017-07-01

    Fracture growth in underground rock structures occurs under complex stress states, which typically include the in- and out-of-plane sliding deformation of jointed rock masses before catastrophic failure. However, the lack of a comprehensive theoretical and experimental fracture toughness study for rocks under contributions of out-of plane deformations (i.e. mode III) is one of the shortcomings of this field. Therefore, in this research the mixed mode I/III fracture toughness of a typical rock material is investigated experimentally by means of a novel cracked disc specimen subjected to bend loading. It was shown that the specimen can provide full combinations of modes I and III and consequently a complete set of mixed mode I/III fracture toughness data were determined for the tested marble rock. By moving from pure mode I towards pure mode III, fracture load was increased; however, the corresponding fracture toughness value became smaller. The obtained experimental fracture toughness results were finally predicted using theoretical and empirical fracture models.

  8. Complexation and molecular modeling studies of europium(III)-gallic acid-amino acid complexes.

    PubMed

    Taha, Mohamed; Khan, Imran; Coutinho, João A P

    2016-04-01

    With many metal-based drugs extensively used today in the treatment of cancer, attention has focused on the development of new coordination compounds with antitumor activity with europium(III) complexes recently introduced as novel anticancer drugs. The aim of this work is to design new Eu(III) complexes with gallic acid, an antioxida'nt phenolic compound. Gallic acid was chosen because it shows anticancer activity without harming health cells. As antioxidant, it helps to protect human cells against oxidative damage that implicated in DNA damage, cancer, and accelerated cell aging. In this work, the formation of binary and ternary complexes of Eu(III) with gallic acid, primary ligand, and amino acids alanine, leucine, isoleucine, and tryptophan was studied by glass electrode potentiometry in aqueous solution containing 0.1M NaNO3 at (298.2 ± 0.1) K. Their overall stability constants were evaluated and the concentration distributions of the complex species in solution were calculated. The protonation constants of gallic acid and amino acids were also determined at our experimental conditions and compared with those predicted by using conductor-like screening model for realistic solvation (COSMO-RS) model. The geometries of Eu(III)-gallic acid complexes were characterized by the density functional theory (DFT). The spectroscopic UV-visible and photoluminescence measurements are carried out to confirm the formation of Eu(III)-gallic acid complexes in aqueous solutions.

  9. Synthesis, spectral and electrochemical studies of binuclear Ru(III) complexes containing dithiosemicarbazone ligand

    NASA Astrophysics Data System (ADS)

    Kanchana Devi, A.; Ramesh, R.

    2014-01-01

    Synthesis of several new octahedral binuclear ruthenium(III) complexes of the general composition [(EPh3)2(X)Ru-L-Ru(X)(EPh3)2] containing benzene dithiosemicarbazone ligands (where E = P or As; X = Cl or Br; L = binucleating ligands) is presented. All the complexes have been fully characterized by elemental analysis, FT-IR, UV-vis and EPR spectroscopy together with magnetic susceptibility measurements. IR study shows that the dithiosemicarbazone ligands behave as dianionic tridentate ligands coordinating through the oxygen atom of the deprotonated phenolic group, nitrogen atom of the azomethine group and thiolate sulphur. In DMF solution, all the complexes exhibit intense d-d transition and ligand-to-metal charge transfer (LMCT) transition in the visible region. The magnetic moment values of the complexes are in the range 1.78-1.82 BM, which reveals the presence of one unpaired electron on each metal ion. The EPR spectra of the liquid samples at LNT show the presence of three different 'g' values (gx ≠ gy ≠ gz) indicate a rhombic distortion around the ruthenium ion. All the complexes exhibit two quasi-reversible one electron oxidation responses (RuIII-RuIII/RuIII-RuIV; RuIII-RuIV/RuIV-RuIV) within the E1/2 range of 0.61-0.74 V and 0.93-0.98 V respectively, versus Ag/AgCl.

  10. An EXAFS spectroscopic study of Am(III) complexation with lactate.

    PubMed

    Fröhlich, Daniel R; Skerencak-Frech, Andrej; Kaplan, Ugras; Koke, Carsten; Rossberg, André; Panak, Petra J

    2015-11-01

    The pH dependence (1-7) of Am(III) complexation with lactate in aqueous solution is studied using extended X-ray absorption fine-structure (EXAFS) spectroscopy. Structural data (coordination numbers, Am--O and Am--C distances) of the formed Am(III)-lactate species are determined from the raw k(3)-weighted Am LIII-edge EXAFS spectra. Between pH 1 and pH 6, Am(III) speciation shifts continuously towards complexed species with increasing pH. At higher pH, the amount of complexed species decreases due to formation of hydroxo species. The coordination numbers and distances (3.41-3.43 Å) of the coordinating carbon atoms clearly point out that lactate is bound `side-on' to Am(III) through both the carboxylic and the α-hydroxy function of lactate. The experimentally determined coordination numbers are compared with speciation calculations on the basis of tabulated thermodynamic stability constants. Both EXAFS data and thermodynamic modelling are in very good agreement. The EXAFS spectra are also analyzed by iterative transformation factor analysis to further verify the determined Am(III) speciation and the used structural model.

  11. [Study on the spectroscopy and electrochemistry of the combination between samarium (III) ion probe and bovine serum albumin].

    PubMed

    Li, Lei; Li, Xun; Qi, Xun; Luo, Guo-tian

    2004-01-01

    The synthesis of solid compound of bovine serum albumin (BSA) with samarium (III) ion was studied. The FTIR spectrum shows that samarium (III) ion forms high sensitivity compound with BSA's oxygen in hydroxyl and nitrogen in amidocyanogen or amide groups. The ultraviolet spectrum shows that samarium (III) ion binds directly with residue of tyrosine. The character of the combination between samarium (III) ion and BSA was studied under simulated physiology conditions. The fluorescence spectrum shows that the molar ratio of samarium (III) ion to BSA is 2.5:1, with apparent complex constant lgK = 11.00. By cyclic voltammetry, the paper reports the stability of compound of BSA with samarium (III) ion and the effect pH on the of combination between samarium (III) ion and BSA.

  12. On the representativeness of coastal aerosol studies to open ocean studies: Mace Head - a case study

    NASA Astrophysics Data System (ADS)

    Rinaldi, M.; Facchini, M. C.; Decesari, S.; Carbone, C.; Finessi, E.; Mircea, M.; Fuzzi, S.; Ceburnis, D.; Ehn, M.; Kulmala, M.; de Leeuw, G.; O'Dowd, C. D.

    2009-12-01

    A unique opportunity arose during the MAP project to compare open ocean aerosol measurements with those undertaken at the Mace Head Global Atmosphere Watch Station, a station used for decades for aerosol process research and long-term monitoring. The objective of the present study is to demonstrate that the key aerosol features and processes observed at Mace Head are characteristic of the open ocean, while acknowledging and allowing for spatial and temporal gradients. Measurements were conducted for a 5-week period at Mace Head and offshore, on the Research Vessel Celtic Explorer, in generally similar marine air masses, albeit not in connected-flow scenarios. The results of the study indicate, in terms of aerosol number size distribution, higher nucleation mode particle concentrations at Mace Head than offshore, pointing to a strong coastal source of new particles that is not representative of the open ocean. The Aitken mode exhibited a large degree of similarity, with no systematic differences between Mace Head and the open ocean, while the accumulation mode showed averagely 35% higher concentrations at Mace Head. The higher accumulation mode concentration can be attributed equally to cloud processing and to a coastal enhancement in concentration. Chemical analysis showed similar or even higher offshore concentrations for dominant species, such as nss-SO4-2, WSOC, WIOC and MSA. Sea salt concentration differences determined a 40% higher supermicron mass at Mace Head, although this difference can be attributed to a higher wind speed at Mace Head during the comparison period. Moreover, the relative chemical composition as a function of size illustrated remarkable similarity. While differences to varying degrees were observed between offshore and coastal measurements, no convincing evidence was found of local coastal effects, apart from nucleation mode aerosol, thus confirming the integrity of previously reported marine aerosol characterisation studies at Mace Head.

  13. Istradefylline improves daytime sleepiness in patients with Parkinson's disease: An open-label, 3-month study.

    PubMed

    Suzuki, Keisuke; Miyamoto, Masayuki; Miyamoto, Tomoyuki; Uchiyama, Tomoyuki; Watanabe, Yuka; Suzuki, Shiho; Kadowaki, Taro; Fujita, Hiroaki; Matsubara, Takeo; Sakuramoto, Hirotaka; Hirata, Koichi

    2017-09-15

    Istradefylline, a selective adenosine A2A receptor antagonist, has been reported to improve daily "off time" and motor symptoms in patients with Parkinson's disease (PD). However, the effect of istradefylline on sleep problems has not been thoroughly investigated. We evaluated the effect of istradefylline on daytime sleepiness, sleep disturbances, and motor symptoms in 22 PD patients who were affected by the wearing off phenomenon in an open-label, 3-month study. Participants received 20-40mg/day istradefylline once daily (morning) over a 3-month period. The Epworth Sleepiness Scale (ESS), PD sleep scale (PDSS)-2 and PD Questionnaire (PDQ-8) were administered at baseline, 2weeks, 1month, 2months and 3months. At baseline and 3months, patients were evaluated on the Movement Disorder Society Revision of the Unified PD Rating Scale (MDS-UPDRS) parts III and IV. Twenty-one patients (95.5%) completed the study. At 3months, MDS-UPDRS part III (-5.3, p=0.0002) and part IV (-2.5, p=0.001) scores improved and off time decreased significantly (-50.1min, p=0.0004). PDQ-8 scores were unchanged at 3months. ESS scores decreased significantly at 2months and 3months (-2.4 and -3.3, respectively, p<0.0001), but the total PDSS-2 scores did not change. Istradefylline improved daytime sleepiness in PD patients, possibly through its effect on enhancing alertness. In addition, the lack of significant changes in the total PDSS-2 scores over the study period suggests istradefylline had no negative impact on sleep. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Luminescence study of Eu(III) analogues of esterase-activated magnetic resonance contrast agents.

    PubMed

    Giardiello, Marco; Lowe, Mark P

    2009-09-07

    A model for an accumulation and enzyme-activation strategy of a magnetic resonance contrast agent was investigated via the luminescence of Eu(III) analogues. Neutral q = 2 Eu(III) ethyl and acetoxymethyl ester LnaDO3A-based complexes showed increased emission intensity in the presence of serum concentrations of carbonate because of inner-sphere water molecule displacement by the anion. The affinity for carbonate is suppressed by the introduction of negative charge to the complex following enzymatic hydrolysis of the ester groups, resulting in quenching of Eu(III) luminescence and changes in spectral form. The conversion of neutral, carboxylic ester-containing complexes into free acid forms by enzymatic hydrolysis using pig liver esterase was demonstrated by luminescence (Eu) and (1)H NMR spectroscopic investigations (Y). These studies demonstrated that the concept of inhibition of anion binding as a result of enzyme activation is feasible.

  15. [Advances in studies of the type III secretion system in Ralstonia solanacearum--A review].

    PubMed

    Zhang, Yong; Li, Muyuan; Luo, Feng

    2015-06-04

    Bacterial wilt caused by Ralstonia solanacearum is one of the most devastating plant diseases worldwide. The syringe-like type III secretion system (T3SS) plays a crucial role in its pathogenicity. R. solanacearum uses the T3SS to inject effector proteins (Type III effectors) into the cytoplasm of host cells, causing diseases in susceptible plants or triggering the hypersensitive response in resistant plants. In this article we review recent advances in studies of R. solanacearum T3SS and highlight their unique features.

  16. An open multicenter comparative randomized clinical study on chitosan.

    PubMed

    Mo, Xiaohui; Cen, John; Gibson, Elaine; Wang, Robin; Percival, Steven L

    2015-01-01

    Chitosan, a natural polysaccharide derivate from chitin, offers a promising alternative biomaterial for use in wound dressings. In this work, the safety and efficacy of a next-generation KA01 chitosan wound dressing in facilitating the healing of nonhealing chronic wounds was studied. This open multicenter comparative prospective randomized clinical study was conducted at three medical centers in China. A total of 90 patients (45 in test group and 45 in control group) with unhealed chronic wounds including pressure ulcers, vascular ulcers, diabetic foot ulcers, and wounds with minor infections, or at risk of infection, were treated with the next generation chitosan wound dressing as the test article or traditional vaseline gauze as a control. Baseline assessments were undertaken with the primary end point being wound area reduction. The secondary end points included pain reduction (using the NRS11 pain scale) at dressing change, wound exudate levels, wound depth and duration of the treatment. After 4 weeks treatment, the wound area reduction was significantly greater in the test group (65.97 ± 4.48%) than the control group (39.95 ± 4.48%). The average pain level in the test group was 1.12 ± 0.23 and 2.30 ± 0.23 in the control group. The wound depth was also lower in the test group 0.30 ± 0.48 cm than the control group 0.54 ± 0.86 cm. The level of exudate fell and the dressing could be removed integrally in both the test and control groups. The mean duration of the test group was 27.31 ± 5.37 days and control group 27.09 ± 6.44 days. No adverse events were reported in either group. In conclusion this open multicenter comparative prospective randomized clinical study has provided compelling evidence that the next generation chitosan wound dressing can enhance wound progression towards healing by facilitating wound reepithelialization and reducing the patients pain level. Furthermore the dressing was shown to be clinically safe and effective in the management

  17. Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed.

    PubMed

    Wilcox, C Mel

    2015-05-21

    Sphincter of Oddi dysfunction (SOD) has been classified into three types based upon the presence or absence of objective findings including liver test abnormalities and bile duct dilatation. Type III is the most controversial and is classified as biliary type pain in the absence of any these objective findings. Many prior studies have shown that the clinical response to endoscopic therapy is higher based upon the presence of these objective criteria. However, there has been variable correlation of the manometry findings to outcome after endoscopic therapy. Nevertheless, manometry and sphincterotomy has been recommended for Type III patients given the overall response rate of 33%, although the reported response rates are highly variable. However, all of the prior data was non-blinded and non-randomized with variable follow-up. The evaluating predictors in SOD study - a prospective randomized blinded sham controlled one year outcome study showed no correlation between manometric findings and outcome after sphincterotomy. Furthermore, patients receiving sham therapy had a statistically significantly better outcome than those undergoing biliary or dual sphincterotomy. This study calls into question the whole concept of SOD Type III and, based upon prior physiologic studies, one can suggest that SOD Type III likely represents a right upper quadrant functional abdominal pain syndrome and should be treated as such.

  18. Open market customer: Volume 2 -- Case study assessments. Final report

    SciTech Connect

    Kotowski, J.; Wikler, G.; Milward, R.; Gudger, K.

    1998-06-01

    This second volume of the Open Market Customer (OMC) contains the case study assessments that illustrate the discussions in Volume 1 and the supporting framework. There are two types of assessments in this volume: actual case studies and prototype case studies. The first, the actual case studies are full OMC assessments of four different types of existing large commercial/industrial facilities. They are, in order of their appearance in this volume: Logan International Airport, Boston, MA--Airport; Washington University, St. Louis, MO--Four-Year University; Cook County Hospital, Chicago, IL--Hospital; and Sierra Pine Ltd., Rocklin, CA--Wood Products Manufacturing. The second type of assessments are the prototype case studies. They were performed on four different types of facilities falling under two market segments. These facilities` models were developed using assumed characteristics, such as floor areas and energy sources. They are, in order of appearance in this volume: Retail Building--small commercial; Sit-Down Restaurant--small commercial; Primary School--small commercial; and Planned Residential Community--residential. For each facility, the characteristics or assumptions are described in detail. Using these characteristics or assumptions a framework for each energy type used on-site was developed. Each framework describes the annual consumption of that energy type as well as the infrastructure supporting it. For example, a facility`s electricity framework shows the estimated annual electricity consumption and expenditures within each of the nine functional areas at that facility. Further, the framework shows the estimated capital associated with each functional area, such as substations, electric distribution lines, and motors. Appendices at the end of this volume contain the frameworks for each case study.

  19. Open-Shell Lanthanide(II+) or -(III+) Complexes Bearing σ-Silyl and Silylene Ligands: Synthesis, Structure, and Bonding Analysis

    PubMed Central

    2015-01-01

    Complexes featuring lanthanide (Ln)–Si bonds represent a highly neglected research area. Herein, we report a series of open-shell LnII+ and LnIII+ complexes bearing σ-bonded silyl and base-stabilized N-heterocyclic silylene (NHSi) ligands. The reactions of the LnIII+ complexes Cp3Ln (Ln = Tm, Ho, Tb, Gd; Cp = cyclopentadienide) with the 18-crown-6 (18-cr-6)-stabilized 1,4-oligosilanyl dianion [(18-cr-6)KSi(SiMe3)2SiMe2SiMe2Si(SiMe3)2K(18-cr-6)] (1) selectively afford the corresponding metallacyclopentasilane salts [Cp2Ln({Si(SiMe3)2SiMe2}2)]−[K2(18-cr-6)2Cp]+ [Ln = Tm (2a), Ho (2b), Tb (2c), Gd (2d)]. Complexes 2a–2d represent the first examples of structurally characterized Tm, Ho, Tb, and Gd complexes featuring Ln–Si bonds. Strikingly, the analogous reaction of 1 with the lighter element analogue Cp3Ce affords the acyclic product [Cp3CeSi(SiMe3)2SiMe2SiMe2Si(SiMe3)2-Cp3Ce]2–2[K(18-cr-6)]+ (3) as the first example of a complex featuring a Ce–Si bond. In an alternative synthetic approach, the aryloxy-functionalized benzamidinato NHSi ligand Si(OC6H4-2-tBu){(NtBu)2CPh} (4a) and the alkoxy analogue Si(OtBu){(NtBu)2CPh} (4b) were reacted with Cp*2Sm(OEt2), affording, by OEt2 elimination, the corresponding silylene complexes, both featuring SmII+ centers: Cp*2Sm ← :Si(O–C6H4-2-tBu){(NtBu)2CPh} (6) and Cp*2Sm ← :Si(OtBu){(NtBu)2CPh} (5). Complexes 5 and 6 are the first four-coordinate silylene complexes of any f-block element to date. All complexes were fully characterized by spectroscopic means and by single-crystal X-ray diffraction analysis. In the series 2a–2d, a linear correlation was observed between the Ln–Si bond lengths and the covalent radii of the corresponding Ln metals. Moreover, in complexes 5 and 6, notably long Sm–Si bonds are observed, in accordance with a donor–acceptor interaction between Si and Sm [5, 3.4396(15) Å; 6, 3.3142(18) Å]. Density functional theory calculations were carried out for complexes 2a–2d, 5, and 6 to

  20. Study of the Need for Educational Manpower for Handicapped Children and Youth: Part D - Volume III, Phase III. State Analysis Reports.

    ERIC Educational Resources Information Center

    Mintz, Raymond D.; And Others

    The document is the third of three volumes (see also EC 032 850 and EC 032 851) OF State Analysis Reports resulting from Phase III of the Study of the Need for Educational Manpower for Handicapped Children and Youth, which involved a validation study and state surveys related to the Manpower Requirements Projection Model (MRPM). Included in the…

  1. 2MASS analytical study of four open cluster candidates

    NASA Astrophysics Data System (ADS)

    Bisht, D.; Yadav, R. K. S.; Durgapal, A. K.

    2017-04-01

    The astrophysical parameters of four poorly studied open star clusters namely Teutsch 126, Teutsch 54, Teutsch 61 and Czernik 3, have been estimated using the Two Micron All Sky Survey (2MASS) database. The stellar density distributions and color-magnitude diagrams are used to determine their structural parameters (cluster center, cluster radius, core radius, tidal radius, Galactocenteric coordinates and the distance from the Galactic plane). We have also derived age, color excesses, total mass, relaxation time, luminosity and mass function for each clusters. The mass function slopes for these clusters are derived as 1.59 ± 0.62, 1.31 ± 0.60, 1.22 ± 0.75 and 1.62 ± 0.56 for Teutsch 126, Teutsch 54, Teutsch 61 and Czernik 3 respectively. These values are very close with the Salpeter value (x = 1.35) within the errors. The effect of mass-segregation are observed in the clusters Teutsch 126 and Teutsch 61. Estimated values of dynamical relaxation time are less than age of the clusters under study. This concludes that these objects are dynamically relaxed. The possible reason for relaxation may be due to the dynamical evolution or imprint of star formation or both.

  2. Numerical study of compressible magnetoconvection with an open transitional boundary

    SciTech Connect

    Hanami, H.; Tajima, T.

    1990-08-01

    We study by computer simulation nonlinear evolution of magnetoconvection in a system with a dynamical open boundary between the convection region and corona of the sun. We study a model in which the fluid is subject to the vertical gravitation, magnetohydrodynamics (MHD), and high stratification, through an MHD code with the MacCormack-Donner cell hybrid scheme in order to well represent convective phenomena. Initially the vertical fluid flux penetrates from the convectively unstable zone at the bottom into the upper diffuse atmosphere. As the instability develops, the magnetic fields are twisted by the convection motion and the folding magnetic fields is observed. When the magnetic pressure is comparable to the thermal pressure in the upper layer of convective zone, strong flux expulsion from the convective cell interior toward the cell boundary appears. Under appropriate conditions our simulation exhibits no shock formation incurred by the fluid convected to the photosphere, in contrast to earlier works with box boundaries. The magnetic field patterns observed are those of concentrated magnetic flux tubes, accumulation of dynamo flux near the bottom boundary, pinched flux near the downdraft region, and the surface movement of magnetic flux toward the downdraft region. Many of these computationally observed features are reminiscent of solar observations of the fluid and magnetic structures of their motions.

  3. Nuclear Magnetic Resonance Studies of II-Vi and Iii-V Semiconductor Alloys

    NASA Astrophysics Data System (ADS)

    Shi, Jian-Hui

    In this thesis, I show how the basic solid-state NMR techniques can be used to study the local electronic structures of II-VI and III-V semiconductor alloys on an atomic scale. We have focused our studies on a few high quality samples, mainly Hg_{rm 1-x}Cd_{rm x} Te in the II-VI group, In-based binary III-V bulk semiconductors InP, InAs and InSb, and the III-V alloys Ga_{rm 1-x}In _{rm x}As. For solid-state-recrystallized device-quality bulk Hg_{rm 1-x}Cd _{rm x}Te samples, with x equal to 0.2, 0.22 and 0.28, corresponding to the narrow-gap semiconducting side of the band-inversion configurations, we have obtained detailed band-edge symmetry information, and site-selective quantitative charge carrier orbital characteristics on an atomic scale. Our study also indicated that a random cation distribution model well described the materials. We have investigated ^{115 }In magnetic resonance frequency shifts and the temperature dependence of these shifts in In-based III-V binary semiconductors. We have extracted the chemical shifts from the total shifts for these III-V semiconductors at 303K and 77K. Our NMR study of these binary semiconductors not only enhanced the understanding of electronic properties of these compounds, but also served as a reference for our NMR studies of III-V alloys. We performed ^{115}In NMR studies for dilute III-V semiconductor alloy Ga _{rm 1-x}In_ {rm x}As with x equal to 0.72%. Spectra clearly indicating the local electronic configurations were obtained. We carried out a series of field orientation studies, and determined the field gradient which is due to In-In pairs. This study provided evidence of local clustering of In atoms.

  4. BVI Photometric Study of the Old Open Cluster Ruprecht 6

    NASA Astrophysics Data System (ADS)

    Kim, Sang Chul; Kyeong, Jaemann; Park, Hong Soo; Han, Ilseung; Lee, Joon Hyeop; Moon, Dae-Sik; Lee, Youngdae; Kim, Seongjae

    2017-06-01

    We present a BVI optical photometric study of the old open cluster Ruprecht 6 using the data obtained with the SMARTS 1.0 m telescope at the CTIO, Chile. Its color-magnitude diagrams show the clear existence of the main-sequence stars, whose turn-off point is located around V ≈ 18.45 mag and B-V ≈ 0.85 mag. Three red clump (RC) stars are identified at V = 16.00 mag, I = 14.41 mag and B-V = 1.35 mag. From the mean K_s-band magnitude of RC stars (K_s=12.39 ± 0.21 mag) in Ruprecht 6 from 2MASS photometry and the known absolute magnitudes of the RC stars (M_{K_S} = -1.595 ± 0.025 mag), we obtain the distance modulus to Ruprecht 6 of (m-M)_0 = 13.84 ± 0.21 mag (d=5.86 ± 0.60 kpc). From the (J-K_s) and (B-V) colors of the RC stars, comparison of the (B-V) and (V-I) colors of the bright stars in Ruprecht 6 with those of the intrinsic colors of dwarf and giant stars, and the PARSEC isochrone fittings, we derive the reddening values of E(B-V) = 0.42 mag and E(V-I) = 0.60 mag. Using the PARSEC isochrone fittings onto the color-magnitude diagrams, we estimate the age and metallicity to be: log(t)=9.50 ± 0.10 (t=3.16 ± 0.82 Gyr) and [Fe/H] = -0.42 ± 0.04 dex. We present the Galactocentric radial metallicity gradient analysis for old (age > 1 Gyr) open clusters of the Dias et al. catalog, which likely follow a single relation of [Fe/H] =(-0.034±0.007) R_{GC} + (0.190±0.080) (rms = 0.201) for the whole radial range or a dual relation of [Fe/H] =(-0.077±0.017) R_{GC} + (0.609±0.161) (rms = 0.152) and constant ([Fe/H] ˜ -0.3 dex) value, inside and outside of R_{GC} ˜ 12 kpc, respectively. The metallicity and Galactocentric radius (13.28± 0.54 kpc) of Ruprecht 6 obtained in this study seem to be consistent with both of the relations.

  5. Probing the Natural World, Level III, Student Guide: Winds and Weather. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's text of one of the units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). The chapters contain basic information about weather, its measurement and predictions, activities related to the subject, and optional excursions. A section of introductory notes to the student discusses how to use…

  6. Social Studies Course III. India: A Cultural Area. Teacher's Manual and Readings.

    ERIC Educational Resources Information Center

    Leppert, Ella C.

    This secondary level instructional unit on India is the second of three cultural areas comprising Course III, "Cultural Areas of Today's World," and follows the first sequential social studies unit on Africa described in SO 003 516. A major objective is for the student to comprehend the characteristics and value structure of India and,…

  7. National Day Care Study First Annual Report. Volume III: Information Management and Data Collection Systems.

    ERIC Educational Resources Information Center

    Goodrich, Nancy; And Others

    Volume III of the National Day Care Study First Annual Report funded by the Office of Child Development describes the information management system which was developed and tested during Phase I. In addition, the volume includes overviews of the sample instruments from the three major data collection systems developed during the year: the Research…

  8. Probing the Natural World, Level III, Teacher's Edition: In Orbit. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of one of the eight units of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on the properties of sunlight, the use of spectrums and spectroscopes, the heat and energy of the sun, the measurement of astronomical distances, and the size of the sun. Optimal…

  9. Probing the Natural World, Level III, Student Guide: In Orbit. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's text of one unit of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). This unit focuses on the properties of sunlight, the use of spectrums and spectroscopes, the heat and energy of the sun, the measurement of astronomical distances, and the size of the sun. Activities are student-centered and…

  10. Probing the Natural World, Level III, Record Book, Teacher's Edition: In Orbit. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the teacher's edition of the Record Book for the unit "In Orbit" of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). The correct answers to the questions from the text are recorded. An introductory note to the student explains how to use the book and is followed by the notes to the teacher.…

  11. LABORATORY STUDY ON THE OXIDATION OF ARSENIC III TO ARSENIC V

    EPA Science Inventory

    A one-year laboratory study was performed to determine the ability of seven oxidants to oxidize As(III) to As(V). These included chlorine, permanganate, ozone, chlorine dioxide, monochloramine, a solid-phase oxidizing media, and 254 nm ultraviolet light. Chlorine and permanganate...

  12. LABORATORY STUDY ON THE OXIDATION OF ARSENIC III TO ARSENIC V

    EPA Science Inventory

    A one-year laboratory study was performed to determine the ability of seven oxidants to oxidize As(III) to As(V). These included chlorine, permanganate, ozone, chlorine dioxide, monochloramine, a solid-phase oxidizing media, and 254 nm ultraviolet light. Chlorine and permanganate...

  13. Probing the Natural World, Level III, Student Guide: Environmental Science. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's edition of one of the Intermediate Science Curriculum Study (ISCS) units for level III students (grade 9). The chapters contain basic information about environmental pollution and hazards, activities related to the subject, and optional excursions. A section on introductory notes to the student discusses how to use the book…

  14. Probing the Natural World, Level III, Student Guide: What's Up? Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's text of one unit of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). The chapters contain basic information about rockets, space, and principles of physics, as well as activities related to the subject and optional excursions. A section of introductory notes to the student discusses how the…

  15. Probing the Natural World, Level III, Record Book, Student Guide: In Orbit. Intermediate Science Curriculum Study.

    ERIC Educational Resources Information Center

    Bonar, John R., Ed.; Hathway, James A., Ed.

    This is the student's edition of the Record Book which accompanies the unit "In Orbit" of the Intermediate Science Curriculum Study (ISCS) for level III students (grade 9). Space is provided for answers to the questions from the student text as well as for the optional excursions and the self evaluation. An introductory note to the…

  16. Civilization III and Whole-Class Play in High School Social Studies

    ERIC Educational Resources Information Center

    Lee, John K.; Probert, Jeffrey

    2010-01-01

    This study examined an 11th grade high school class as they played the game Civilization III. Over nine class sessions students played the game in support of other activities related to several predetermined and emergent topics in U. S. history. Gameplay was whole-class oriented and involved students taking turns at the computer controlling…

  17. Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms' tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial.

    PubMed

    Pritchard-Jones, Kathy; Bergeron, Christophe; de Camargo, Beatriz; van den Heuvel-Eibrink, Marry M; Acha, Tomas; Godzinski, Jan; Oldenburger, Foppe; Boccon-Gibod, Liliane; Leuschner, Ivo; Vujanic, Gordan; Sandstedt, Bengt; de Kraker, Jan; van Tinteren, Harm; Graf, Norbert

    2015-09-19

    Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely from chemotherapy for stage II-III, histological intermediate-risk Wilms' tumour when a newly defined high-risk blastemal subtype was excluded from randomisation. For this international, multicentre, open-label, non-inferiority, phase 3, randomised SIOP WT 2001 trial, we recruited children aged 6 months to 18 years at the time of diagnosis of a primary renal tumour from 251 hospitals in 26 countries who had received 4 weeks of preoperative chemotherapy with vincristine and actinomycin D. Children with stage II-III intermediate-risk Wilms' tumours assessed after delayed nephrectomy were randomly assigned (1:1) by a minimisation technique to receive vincristine 1·5 mg/m(2) at weeks 1-8, 11, 12, 14, 15, 17, 18, 20, 21, 23, 24, 26, and 27, plus actinomycin D 45 μg/kg every 3 weeks from week 2, either with five doses of doxorubicin 50 mg/m(2) given every 6 weeks from week 2 (standard treatment) or without doxorubicin (experimental treatment). The primary endpoint was non-inferiority of event-free survival at 2 years, analysed by intention to treat and a margin of 10%. Assessment of safety and adverse events included systematic monitoring of hepatic toxicity and cardiotoxicity. This trial is registered with EudraCT, number 2007-004591-39, and is closed to new participants. Between Nov 1, 2001, and Dec 16, 2009, we recruited 583 patients, 341 with stage II and 242 with stage III tumours, and randomly assigned 291 children to treatment including doxorubicin, and 292 children to treatment excluding doxorubicin. Median follow-up was 60·8 months (IQR 40·8-79·8). 2 year event-free survival was

  18. Type III frontal sinusotomy: surgical technique, indications, outcomes, a multi-university retrospective study of 120 cases.

    PubMed

    Eloy, P; Vlaminck, S; Jorissen, M; Hellings, P; Timmermans, M; Daele, J; Ransky, P; Hassid, S; Van Zele, T; Bachert, C; Poirrier, A L; Bertrand, B

    2011-01-01

    Draf in 1991. The procedure--which is also known as the modified endoscopic Lothrop procedure--aims to create the largest possible anteroposterior and lateral to lateral opening between both frontal sinuses and the nasal cavities. This requires the resection of the medial floor of both frontal sinuses, the intersinus septum and the superior nasal septum. The authors present a retrospective study including a cohort of 120 patients who underwent surgery in six Belgian university ENT departments. Mean follow-up was 24.6 months (range: 5-36 months). This paper describes the surgical procedure and reviews the indications, comorbidities, outcomes and complications of the type III frontal sinusotomy. Some correlations are also established with the data published in the worldwide literature. The authors conclude that the Draf III is a demanding procedure requiring considerable expertise in endoscopic sinus surgery. The procedure is effective with a success rate of 87.5%. Indeed, 12.5% of patients only experienced closure of the neoostium while 20% of all the patients had unchanged or worse symptomatology. The percentage of post-operative complications is 7.5%. All complications were managed successfully.

  19. WIYN Open Cluster Study: UBVRI Photometry of NGC 2158

    NASA Astrophysics Data System (ADS)

    Taverne, Luke T.; Steinhauer, Aaron J.; Deliyannis, Constantine P.

    2015-01-01

    We present WIYN 0.9m HDI UBVRI photometry of NGC 2158, a very rich, intermediate-aged, open cluster located near the galactic anti-center. We report derived values for the cluster age, distance, reddening.

  20. Posterior tibial slope changes after opening- and closing-wedge high tibial osteotomy: a comparative prospective multicenter study.

    PubMed

    Ducat, A; Sariali, E; Lebel, B; Mertl, P; Hernigou, P; Flecher, X; Zayni, R; Bonnin, M; Jalil, R; Amzallag, J; Rosset, P; Servien, E; Gaudot, F; Judet, T; Catonné, Y

    2012-02-01

    since the open-wedge technique was preferred in cases with substantial varus deformity. We emphasize the importance of surgical technique to avoid alteration of the tibial slope, particularly in opening-wedge high tibial osteotomy for which we recommend a release of posterior soft tissue and a complete osteotomy of the posterior cortex of the tibia. III. Prospective consecutive nonrandomized multicenter study. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  1. Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on plasma apolipoprotein C-III levels in patients from the MARINE and ANCHOR studies.

    PubMed

    Ballantyne, Christie M; Bays, Harold E; Braeckman, Rene A; Philip, Sephy; Stirtan, William G; Doyle, Ralph T; Soni, Paresh N; Juliano, Rebecca A

    2016-01-01

    Apolipoprotein C-III (ApoC-III) regulates lipoprotein and triglyceride (TG) metabolism and may have a causal role in cardiovascular disease. In the Multi-Center, Placebo-Controlled, Randomized, Double-Blind, 12-Week Study With an Open-Label Extension (MARINE) and ANCHOR studies, icosapent ethyl, a high-purity prescription eicosapentaenoic acid ethyl ester, reduced TG, and other atherogenic lipid parameters without increasing low-density lipoprotein cholesterol (LDL-C) compared with placebo. To evaluate the effects of icosapent ethyl on plasma ApoC-III levels in patients from 2 phase 3 studies. MARINE and ANCHOR were 12-week double-blind studies of icosapent ethyl in adult patients. Patients in MARINE had very high TG levels (≥500 and ≤2000 mg/dL) and patients in ANCHOR had high TG levels (≥200 and <500 mg/dL) despite statin control of LDL-C. This post hoc analysis of MARINE and ANCHOR assessed the median percent change from baseline in plasma ApoC-III levels vs placebo and includes subgroup analyses by statin use/efficacy and median ApoC-III levels. We assessed ApoC-III levels in 148 and 612 patients in the MARINE and ANCHOR studies, respectively. In MARINE, the approved prescription dose of icosapent ethyl (4 g/day) significantly reduced ApoC-III levels by 25.1% (P < .0001) vs placebo. In ANCHOR, icosapent ethyl 4 g/day significantly reduced ApoC-III levels by 19.2% (P < .0001) vs placebo; subanalysis by statin efficacy revealed significant reductions vs placebo in the higher-efficacy and medium-efficacy groups (24.6% and 17.2%, respectively; both P < .0001). Icosapent ethyl 4 g/day significantly reduced plasma ApoC-III levels in patients with elevated TGs from the MARINE and ANCHOR studies. Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  2. Star formation in Chamaeleon I and III: a molecular line study of the starless core population

    NASA Astrophysics Data System (ADS)

    Tsitali, A. E.; Belloche, A.; Garrod, R. T.; Parise, B.; Menten, K. M.

    2015-03-01

    Context. The Chamaeleon dark molecular clouds are excellent nearby targets for low-mass star formation studies. Even though they belong to the same cloud complex, Cha I and II are actively forming stars while Cha III shows no sign of ongoing star formation. Aims: We aim to determine the driving factors that have led to the very different levels of star formation activity in Cha I and III and examine the dynamical state and possible evolution of the starless cores within them. Methods: Observations were performed in various molecular transitions with the APEX and Mopra telescopes. We examine the kinematics of the starless cores in the clouds through a virial analysis, a search for contraction motions, and velocity gradients. The chemical differences in the two clouds are explored through their fractional molecular abundances, derived from a non-LTE analysis, and comparison to predictions of chemical models. Results: Five cores are gravitationally bound in Cha I and one in Cha III. The so-called infall signature indicating contraction motions is seen toward 8-17 cores in Cha I and 2-5 cores in Cha III, which leads to a range of 13-28% of the cores in Cha I and 10-25% of the cores in Cha III that are contracting and may become prestellar. There is no significant difference in the turbulence level in the two clouds. Future dynamical interactions between the cores will not be dynamically significant in either Cha I or III, but the subregion Cha I North may experience collisions between cores within ~0.7 Myr. Turbulence dissipation in the cores of both clouds is seen in the high-density tracers N2H+ 1-0 and HC3N 10-9 which have lower non-thermal velocity dispersions compared to C17O 2-1, C18O 2-1, and C34S 2-1. Evidence of depletion in the Cha I core interiors is seen in the abundance distributions of the latter three molecules. The median fractional abundance of C18O is lower in Cha III than Cha I by a factor of ~2. The median abundances of most molecules (except

  3. A spectroscopic study of the open cluster NGC 6250

    NASA Astrophysics Data System (ADS)

    Martin, A. J.; Stift, M. J.; Fossati, L.; Bagnulo, S.; Scalia, C.; Leone, F.; Smalley, B.

    2017-04-01

    We present the chemical abundance analysis of 19 upper main-sequence stars of the young open cluster NGC 6250 (log t ∼ 7.42 yr). This work is part of a project aimed at setting observational constraints on the theory of atomic diffusion in stellar photospheres, by means of a systematic study of the abundances of the chemical elements of early F-, A- and late B-type stars of well-determined age. Our data set consists of low-, medium- and high-resolution spectra obtained with the Fibre Large Array Multi Element Spectrograph (FLAMES) instrument of the ESO Very Large Telescope (VLT). To perform our analysis, we have developed a new suite of software tools for the chemical abundance analysis of stellar photospheres in local thermodynamical equilibrium. Together with the chemical composition of the stellar photospheres, we have provided new estimates of the cluster mean radial velocity, proper motion, refined the cluster membership, and we have given the stellar parameters including masses and fractional age. We find no evidence of statistically significant correlation between any of the parameters, including abundance and cluster age, except perhaps for an increase in Ba abundance with cluster age. We have proven that our new software tool may be successfully used for the chemical abundance analysis of large data sets of stellar spectra.

  4. Metabolome-Wide Association Study of Primary Open Angle Glaucoma

    PubMed Central

    Burgess, L. Goodwin; Uppal, Karan; Walker, Douglas I.; Roberson, Rachel M.; Tran, ViLinh; Parks, Megan B.; Wade, Emily A.; May, Alexandra T.; Umfress, Allison C.; Jarrell, Kelli L.; Stanley, Brooklyn O. C.; Kuchtey, John; Kuchtey, Rachel W.; Jones, Dean P.; Brantley, Milam A.

    2015-01-01

    Purpose To determine if primary open-angle glaucoma (POAG) patients can be differentiated from controls based on metabolic characteristics. Methods We used ultra-high resolution mass spectrometry with C18 liquid chromatography for metabolomic analysis on frozen plasma samples from 72 POAG patients and 72 controls. Metabolome-wide Spearman correlation was performed to select differentially expressed metabolites (DEM) correlated with POAG. We corrected P values for multiple testing using Benjamini and Hochberg false discovery rate (FDR). Hierarchical cluster analysis (HCA) was used to depict the relationship between participants and DEM. Differentially expressed metabolites were matched to the METLIN metabolomics database; both DEM and metabolites significantly correlating with DEM were analyzed using MetaboAnalyst to identify metabolic pathways altered in POAG. Results Of the 2440 m/z (mass/charge) features recovered after filtering, 41 differed between POAG cases and controls at FDR = 0.05. Hierarchical cluster analysis revealed these DEM to associate into eight clusters; three of these clusters contained the majority of the DEM and included palmitoylcarnitine, hydroxyergocalciferol, and high-resolution METLIN matches to sphingolipids, other vitamin D-related metabolites, and terpenes. MetaboAnalyst also indicated likely alteration in steroid biosynthesis pathways. Conclusions Global ultrahigh resolution metabolomics emphasized the importance of altered lipid metabolism in POAG. The results suggest specific metabolic processes, such as those involving palmitoylcarnitine, sphingolipids, vitamin D-related compounds, and steroid precursors, may contribute to POAG status and merit more detailed study with targeted methods. PMID:26230767

  5. A Photometric Study of Five Open Clusters in the SDSS

    NASA Astrophysics Data System (ADS)

    Ryu, Jinhyuk; Lee, Myung Gyoon

    2011-10-01

    We present a photometric study of five open clusters (Czernik 5, Alessi 53, Berkeley 49, Berkeley 84, and Pfleiderer 3) in the Sloan Digital Sky Survey. The position and size of these clusters are determined using the radial number density profiles of the stars, and the member stars of the clusters are selected using the proper motion data in the literature. We estimate the reddening, distance and age of the clusters based on the isochrone fitting in the color-magnitude diagram. The foreground reddenings for these clusters are estimated to be E(B-V)=0.71-1.55 mag. The distances to these clusters are derived to be 2.0-4.4 kpc, and their distances from the Galactic center range from 7.57 kpc to 12.35 kpc. Their ages are in the range from 250 Myr to 1 Gyr. Berkeley 49 and Berkeley 84 are located in the Orion spur, Czernik 5 is in the Perseus arm, and Pfleiderer 3 and Alessi 53 are located beyond the Perseus arm.

  6. The simple script wrapper for OpenMI:Enabling interdisciplinary modeling studies

    USDA-ARS?s Scientific Manuscript database

    Integrated environmental modeling enables the development of comprehensive simulations by compositing individual models within and across disciplines. The Simple Script Wrapper (SSW), developed here, provides a foundation for model linkages and integrated studies. The Open Modeling Interface (OpenMI...

  7. Oxidative study of gabapentin by alkaline hexacyanoferrate(III) in room temperature in presence of catalytic amount of Ru(III) a mechanistic approach

    NASA Astrophysics Data System (ADS)

    Jose, Timy P.; Angadi, Mahantesh A.; Salunke, Manjalee S.; Tuwar, Suresh M.

    2008-12-01

    The kinetics of oxidation of gabapentin by hexacyanoferrate(III) in aqueous alkaline medium at a constant ionic strength of 0.5 mol dm -3 was studied spectrophotometrically. The reaction is of first order in [HCF(III)] and of less than unit order in [alkali]. The reaction rate is independent upon [gabapentin]. Effects of added products, ionic strength and dielectric constant of the reaction medium have been investigated. Oxidative product of gabapentin was identified. A suitable mechanism has been proposed. The reaction constants involved in the different steps of mechanism are calculated. The activation parameters of the mechanism are computed and discussed .

  8. Structure of type I and type III heterotypic collagen fibrils: an X-ray diffraction study.

    PubMed

    Cameron, G J; Alberts, I L; Laing, J H; Wess, T J

    2002-01-01

    The molecular packing arrangement within collagen fibrils has a significant effect on the tensile properties of tissues. To date, most studies have focused on homotypic fibrils composed of type I collagen. This study investigates the packing of type I/III collagen molecules in heterotypic fibrils of colonic submucosa using a combination of X-ray diffraction data, molecular model building, and simulated X-ray diffraction fibre diagrams. A model comprising a 70-nm-diameter D- (approximately 65 nm) axial periodic structure containing type I and type III collagen chains was constructed from amino acid scattering factors organised in a liquid-like lateral packing arrangement simulated using a classical Lennard-Jones potential. The models that gave the most accurate correspondence with diffraction data revealed that the structure of the fibril involves liquid-like lateral packing combined with a constant helical inclination angle for molecules throughout the fibril. Combinations of type I:type III scattering factors in a ratio of 4:1 gave a reasonable correspondence with the meridional diffraction series. The attenuation of the meridional intensities may be explained by a blurring of the electron density profile of the D period caused by nonspecific or random interactions between collagen types I and III in the heterotypic fibril. (c) 2002 Elsevier Science (USA).

  9. Open Mind, Open Heart: An Anthropological Study of the Therapeutics of Meditation Practice in the US.

    PubMed

    Myers, Neely; Lewis, Sara; Dutton, Mary Ann

    2015-09-01

    Based on ethnographic fieldwork and interviews collected with meditation teachers and students in the United States, this article will argue that active training in meditation-based practices occasions the opportunity for people with traumatic stress to develop a stronger mind-body connection through heightened somatic awareness and a focus on the present moment that they find to be therapeutic. Three important themes related to healing through meditation for trauma emerged from the data and centered around the ways our interlocutors attempted to realign their sense of self, mind and body, after a traumatic experience. The themes helped explain why US women perceive meditation as therapeutic for trauma, namely that the practice of meditation enables one to focus on the lived present rather than traumatic memories, to accept pain and "open" one's heart, and to make use of silence instead of speech as a healing modality. As meditation practices increasingly enter global popular culture, promoted for postulated health benefits, the driving question of this research--how meditation may perpetuate human resilience for women who have experienced trauma based on their own perspectives of meditation practices--is a critical addition to the literature.

  10. Spa therapy for generalized osteoarthritis: an open, observational, preliminary study.

    PubMed

    Erol, Fatma Begüm; Forestier, Romain J; Güneri, Fulya Demircioğlu; Karagülle, M Zeki; Erdoğan, Nergis

    2015-01-01

    Open, prospective study to evaluate the effect of spa therapy on generalized osteoarthritis (GOA). Patients diagnosed as GOA were recruited from a private outpatient clinic. The treatment protocol was designed with 6 different spa modalities, 3 for each consecutive day, during 18 days. Interventions were Berthollet's technique (local mineral water cloud application), peloidotherapy, hydrotherapy, under water /standard (dry) massage, supervised water exercise, bath in hydro-massage pool, bath in tub with hydro-jets, free immersion in mineral water pool. The primary outcome was a clinically relevant improvement in 50% of patients at the end of the treatment. Statistical analyses were based on intention-to-treat method. Health care providers were blinded to the study. Ninety nine patients were included between March 7th-April 29th 2011 and all were analyzed for the primary outcome. Clinically relevant improvement was observed in 61% of the patients at the end of the treatment, and 68% at the 8th month. Patient acceptable symptom state was achieved in 33% of the patients at the 3rd week and 75% at the 8th month and Outcome Measures in Rheumatology-Osteoarthritis Research Society International Criteria (OMERACT-OARSI criteria) response in 41% of the patients at the 3rd week and 19% at the 8th month. Improvement was also observed in other judgment criteria evaluating pain, function and quality of life and continued until the 8th month for some of the parameters. No serious adverse effect was observed. Spa treatment may improve the clinical status of patients with GOA and seems to be well tolerated. © 2014 Société Française de Pharmacologie et de Thérapeutique.

  11. Studies on chemistry, spectroscopy and antioxidant activities of chromium(III)-hydrazide complexes.

    PubMed

    Shamshad, Bushra; Jamal, Rifat A; Ashiq, Uzma; Mahrooof-Tahir, Mohammad; Shaikh, Zara; Sultan, Sadaf; Khan, Khalid M

    2015-01-01

    Acid hydrazides are vital chemical entities due to their biological activities. Upon complexation with certain metal ions, their biological activities are known to be positively enhanced. The present work describes the synthesis of Cr(III)-hydrazide complexes, and their structural, spectroscopic and antioxidant properties to reveal their chemistry and biochemistry. Physical (magnetic moment, conductivity measurements), analytical (C, H, N and Cr analysis) and spectral (EI-Mass, FTIR) techniques are used for the characterization of synthesized compounds. All Cr(III)-hydrazide complexes exhibit octahedral geometry with general formula [Cr(L)2(H2O)2]Cl3. In these complexes, the hydrazide ligands are coordinated via carbonyl oxygen and terminal amino nitrogen in a bidentate fashion. All Cr(III)-hydrazide complexes were screened for in vitro diphenyldipicryl hydrazine (DPPH), superoxide dismutase and nitric oxide radical scavenging activities. Majority of the Cr(III)-hydrazide complexes were found to be more potent scavengers than their uncoordinated hydrazide ligands. This study demonstrates an interesting structure-activity relationship (SAR) which is presented here.

  12. Synthesis of Cr(III)-Morin Complex: Characterization and Antioxidant Study

    PubMed Central

    Panhwar, Qadeer K.; Memon, Shahabuddin

    2014-01-01

    The complex formation between Cr(III) and morin was carried out in methanol and confirmed by analytical characterization using UV-Vis, IR, 1H NMR, and TG-DTA. UV-Vis shows significant bathochromic shift in benzoyl upon coordination as well as IR well illustrates the peak shift of C=O group and formation of a O–Cr(III) bond. Likewise, 1H NMR studies clarify that Cr(III) metal ion replaces the 5OH proton hence; 5-hydroxy-4-keto site is employed by morin in chelation to form six-membered stable ring system out of three available chelating sites. In addition, TG-DTA denotes the presence of coordinated and crystalline water molecules. The melting point of the complex was found to be 389°C by DSC. In addition, Cr(III)-morin complex was found to be a more potent antioxidant than morin as evaluated by DPPH• and FRAP methods. PMID:24688439

  13. Biological and protein-binding studies of newly synthesized polymer-cobalt(III) complexes.

    PubMed

    Vignesh, G; Pradeep, I; Arunachalam, S; Vignesh, S; Arthur James, R; Arun, R; Premkumar, K

    2016-03-01

    The polymer-cobalt(III) complexes, [Co(bpy)(dien)BPEI]Cl3 · 4H2O (bpy = 2,2'-bipyridine, dien = diethylentriamine, BPEI = branched polyethyleneimine) were synthesized and characterized. The interaction of these complexes with human serum albumin (HSA) and bovine serum albumin (BSA) was investigated under physiological conditions using various physico-chemical techniques. The results reveal that the fluorescence quenching of serum albumins by polymer-cobalt(III) complexes took place through static quenching. The binding of these complexes changed the molecular conformation of the protein considerably. The polymer-cobalt(III) complex with x = 0.365 shows antimicrobial activity against several human pathogens. This complex also induces cytotoxicity against MCF-7 through apoptotic induction. However, further studies are needed to decipher the molecular mode of action of polymer-cobalt(III) complex and for its possible utilization in anticancer therapy. Copyright © 2015 John Wiley & Sons, Ltd.

  14. Tocotrienol Treatment in Familial Dysautonomia: Open-Label Pilot Study.

    PubMed

    Cheishvili, David; Maayan, Channa; Holzer, Naama; Tsenter, Jeanna; Lax, Elad; Petropoulos, Sophie; Razin, Aharon

    2016-07-01

    Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy, primarily presented in Ashkenazi Jews. The most common mutation in FD patients results from a single base pair substitution of an intronic splice site in the IKBKAP gene which disrupts normal mRNA splicing and leads to tissue-specific reduction of IKBKAP protein (IKAP). To date, treatment of FD patients remains preventative, symptomatic and supportive. Based on previous in vitro evidence that tocotrienols, members of the vitamin E family, upregulate transcription of the IKBKAP gene, we aimed to investigate whether a similar effects was observed in vivo. In the current study, we assessed the effects of tocotrienol treatment on FD patients' symptoms and IKBKAP expression in white blood cells. The initial daily doses of 50 or 100 mg tocotrienol, doubled after 3 months, was administered to 32 FD patients. Twenty-eight FD patients completed the 6-month study. The first 3 months of tocotrienol treatment was associated with a significant increase in IKBKAP expression level in FD patients' blood. Despite doubling the dose after the initial 3 months of treatment, IKBKAP expression level returned to baseline by the end of the 6-month treatment. Clinical improvement was noted in the reported clinical questionnaire (with regard to dizziness, bloching, sweating, number of pneumonia, cough episodes, and walking stability), however, no significant effect was observed in any clinical measurements (weight, height, oxygen saturation, blood pressure, tear production, histamine test, vibration threshold test, nerve conduction, and heart rate variability) following Tocotrienol treatment. In conclusion, tocotrienol treatment appears significantly beneficial by clinical evaluation for some FD patients in a few clinical parameters; however it was not significant by clinical measurements. This open-label study shows the complexity of effect of tocotrienol treatment on FD patients' clinical outcomes and on

  15. Phase I-II study of isotopic immunoglobulin therapy for primary liver cancer

    SciTech Connect

    Ettinger, D.S.; Order, S.E.; Wharam, M.D.; Parker, M.K.; Klein, J.L.; Leichner, P.K.

    1982-02-01

    A phase I-II study of isotopic immunoglobulin therapy was performed in 18 patients with primary liver cancer; 14 were evaluable for toxicity. The patients received a dose of 37-157 millicuries of 131I-labeled antibody. The dose-limiting factor appears to be hematologic toxicity, especially thrombocytopenia. An objective antitumor effect was seen in six of nine patients who were evaluable for response. Present results suggest that further clinical studies with isotopic immunoglobulin are indicated.

  16. Caffeine in Parkinson's disease: a pilot open-label, dose-escalation study.

    PubMed

    Altman, Robert D; Lang, Anthony E; Postuma, Ronald B

    2011-11-01

    Epidemiologic studies consistently find an inverse association between caffeine use and PD. Numerous explanations exist, but are difficult to evaluate as caffeine's symptomatic effect and tolerability in PD are unknown. We designed an open-label, 6-week dose-escalation study of caffeine to establish dose tolerability and evaluate potential motor/nonmotor benefits. Caffeine was started at 200 mg daily and was increased to a maximum of 1,000 mg. Of 25 subjects, 20 tolerated 200 mg, 17 tolerated 400 mg, 7 tolerated 800 mg, and 3 tolerated 1,000 mg. The most common adverse events were gastrointestinal discomfort, anxiety, and worsening/emerging tremor. At 400 mg daily, we found potential improvements in motor manifestations and somnolence (UPDRS III: -4.5 ± 4.6, P = 0.003; Epworth: -2.0 ± 3.0, P = 0.015). Maximum dose tolerability for caffeine in PD appears to be 100 to 200 mg BID. We found pilot preliminary evidence that caffeine may improve some motor and nonmotor aspects of PD, which must be confirmed in longer term, placebo-controlled, clinical trials. Copyright © 2011 Movement Disorder Society.

  17. Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study.

    PubMed

    Sharma, Alok; Gokulchandran, Nandini; Sane, Hemangi; Nagrajan, Anjana; Paranjape, Amruta; Kulkarni, Pooja; Shetty, Akshata; Mishra, Priti; Kali, Mrudula; Biju, Hema; Badhe, Prerna

    2013-01-01

    Cellular therapy is an emerging therapeutic modality with a great potential for the treatment of autism. Recent findings show that the major underlying pathogenetic mechanisms of autism are hypoperfusion and immune alterations in the brain. So conceptually, cellular therapy which facilitates counteractive processes of improving perfusion by angiogenesis and balancing inflammation by immune regulation would exhibit beneficial clinical effects in patients with autism. This is an open label proof of concept study of autologous bone marrow mononuclear cells (BMMNCs) intrathecal transplantation in 32 patients with autism followed by multidisciplinary therapies. All patients were followed up for 26 months (mean 12.7). Outcome measures used were ISAA, CGI, and FIM/Wee-FIM scales. Positron Emission Tomography-Computed Tomography (PET-CT) scan recorded objective changes. Out of 32 patients, a total of 29 (91%) patients improved on total ISAA scores and 20 patients (62%) showed decreased severity on CGI-I. The difference between pre- and postscores was statistically significant (P < 0.001) on Wilcoxon matched-pairs signed rank test. On CGI-II 96% of patients showed global improvement. The efficacy was measured on CGI-III efficacy index. Few adverse events including seizures in three patients were controlled with medications. The encouraging results of this leading clinical study provide future directions for application of cellular therapy in autism.

  18. Phase III study of combined chemohormonal therapy in metastatic prostate cancer (ECOG 3882): an Eastern Cooperative Oncology Group study.

    PubMed

    Leaf, Andrea N; Propert, Kathleen; Corcoran, Chris; Catalano, Paul J; Trump, Donald L; Harris, Jules E; Davis, Thomas E

    2003-01-01

    This study, a phase III multicenter randomized trial opened by ECOG in April 1983 and closed in June 1986 was designed to evaluate whether a combination of doxorubicin and an intravenous formulation of diethylstilbestrol diphosphate (DES) was superior to doxorubicin alone in men with hormone refractory prostate cancer. All patients received doxorubicin at a dose of 50 mg/m2 iv every 3 wk either alone or with 1 g DES iv daily for 5 d followed by 1 g iv twice weekly for four cycles (12 wk). The 51 evaluable patients with visceral metastases displayed a significantly increased response rate (27% vs 63%) on the combined therapy arm (p = 0.04). However, the 111 evaluable patients with osseous disease exhibited no difference in response rate between either arm with a p-value of >0.99. Similarly, clinical response rates revealed no difference between the two arms. Cases of cardiac toxicity graded as severe, life threatening, or lethal in the combined therapy arm were 10 times more frequent in the combined-therapy arm than in the doxorubicin-alone group (6.75% compared to 0.7%). This difference was statistically significant (p = 0.0041). All of the cases of superficial and deep venous thrombosis occurred on the combined-therapy arm. There were no other significant differences in the numbers of grade 3 or 4 toxic events. The most common toxicity was hematologic. Failure-free survival duration did reach statistical significance in the combined-therapy group (p = 0.012), although the actual durations were short (2.6-3.2 mo). There was no difference in overall survival between the two groups.

  19. Pasireotide treatment significantly improves clinical signs and symptoms in patients with Cushing's disease: results from a Phase III study.

    PubMed

    Pivonello, Rosario; Petersenn, Stephan; Newell-Price, John; Findling, James W; Gu, Feng; Maldonado, Mario; Trovato, Andrew; Hughes, Gareth; Salgado, Luiz R; Lacroix, André; Schopohl, Jochen; Biller, Beverly M K

    2014-09-01

    Signs and symptoms of Cushing's disease are associated with high burden of illness. In this analysis, we evaluated the effect of pasireotide treatment on signs and symptoms in patients with Cushing's disease. Phase III study with double-blind randomization of two pasireotide doses. Patients (n = 162) with persistent/recurrent or de novo Cushing's disease and urinary free cortisol (UFC) levels ≥1·5× upper limit of normal (ULN) were randomized to receive subcutaneous pasireotide (600/900 μg bid). At month 3, patients with UFC ≤2 × ULN and not exceeding the baseline value continued their randomized dose; all others received 300 μg bid uptitration. At month 6, patients could enter an open-label phase until month 12 with a maximal dose of 1200 μg bid. Changes in signs and symptoms of hypercortisolism over 12 months' treatment in patients still enroled in the study and with evaluable measurements were assessed in relation to degree of UFC control. Reductions in blood pressure were observed even without full UFC control and were greatest in patients who did not receive antihypertensive medications during the study. Significant reductions in total cholesterol and low-density lipoprotein (LDL)-cholesterol were observed in patients who achieved UFC control. Reductions in BMI, weight and waist circumference occurred during the study even without full UFC control. Adverse effects were typical of somatostatin analogues except for hyperglycaemia-related events, which were experienced by 72·8% of patients. In the largest Phase III study of medical therapy in Cushing's disease, significant improvements in signs and symptoms were seen during 12 months of pasireotide treatment, as UFC levels decreased. © 2014 John Wiley & Sons Ltd.

  20. NMR and molecular dynamics studies of the conformational epitope of the type III group B Streptococcus capsular polysaccharide and derivatives.

    PubMed

    Brisson, J R; Uhrinova, S; Woods, R J; van der Zwan, M; Jarrell, H C; Paoletti, L C; Kasper, D L; Jennings, H J

    1997-03-18

    The conformational epitope of the type III group B Streptococcus capsular polysaccharide (GBSP III) exhibits unique properties which can be ascribed to the presence of sialic acid in its structure and the requirement for an extended binding site. By means of NMR and molecular dynamics studies on GBSP III and its fragments, the extended epitope of GBSP III was further defined. The influence of sialic acid on the conformational properties of GBSP III was examined by performing conformational analysis on desialylated GBSP III, which is identical to the polysaccharide of Streptococcus pneumoniae type 14, and also on oxidized and reduced GBSP III. Conformational changes were gauged by 1H and 13C chemical shift analysis, NOE, 1D selective TOCSY-NOESY experiments, J(HH) and J(CH) variations, and NOE of OH resonances. Changes in mobility were examined by 13C T1 and T2 measurements. Unrestrained molecular dynamics simulations with explicit water using the AMBER force field and the GLYCAM parameter set were used to assess static and dynamic conformational models, simulate the observable NMR parameters and calculate helical parameters. GBSP III was found to be capable of forming extended helices. Hence, the length dependence of the conformational epitope could be explained by its location on extended helices within the random coil structure of GBSP III. The interaction of sialic acid with the backbone of the PS was also found to be important in defining the conformational epitope of GBSP III.

  1. Studying at the Open University of the Netherlands, Developments 1984-1987.

    ERIC Educational Resources Information Center

    Boon, J.; van Enckevort, G.

    A study examined the success of the first three years of the Dutch Open University's operation by analyzing data pertaining to students' backgrounds and academic progress while enrolled in the open university. The fact that registered inquiries about the Dutch Open University rose from 120,000 during the summer and autumn of 1984 to more than…

  2. A Bibliometric Study of Scholarly Articles Published by Library and Information Science Authors about Open Access

    ERIC Educational Resources Information Center

    Grandbois, Jennifer; Beheshti, Jamshid

    2014-01-01

    Introduction: This study aims to gain a greater understanding of the development of open access practices amongst library and information science authors, since their role is integral to the success of the broader open access movement. Method: Data were collected from scholarly articles about open access by library and information science authors…

  3. Lesbian, Gay, and Heterosexual Couples in Open Adoption Arrangements: A Qualitative Study

    ERIC Educational Resources Information Center

    Goldberg, Abbie E.; Kinkler, Lori A.; Richardson, Hannah B.; Downing, Jordan B.

    2011-01-01

    Little research has attended to the role of gender and sexual orientation in shaping open adoption dynamics. This qualitative, longitudinal study of 45 adoptive couples (15 lesbian, 15 gay, and 15 heterosexual couples) examined adopters' motivations for open adoption, changes in attitudes about openness, and early relationship dynamics. Key…

  4. Studying at the Open University of the Netherlands, Developments 1984-1987.

    ERIC Educational Resources Information Center

    Boon, J.; van Enckevort, G.

    A study examined the success of the first three years of the Dutch Open University's operation by analyzing data pertaining to students' backgrounds and academic progress while enrolled in the open university. The fact that registered inquiries about the Dutch Open University rose from 120,000 during the summer and autumn of 1984 to more than…

  5. Lesbian, Gay, and Heterosexual Couples in Open Adoption Arrangements: A Qualitative Study

    ERIC Educational Resources Information Center

    Goldberg, Abbie E.; Kinkler, Lori A.; Richardson, Hannah B.; Downing, Jordan B.

    2011-01-01

    Little research has attended to the role of gender and sexual orientation in shaping open adoption dynamics. This qualitative, longitudinal study of 45 adoptive couples (15 lesbian, 15 gay, and 15 heterosexual couples) examined adopters' motivations for open adoption, changes in attitudes about openness, and early relationship dynamics. Key…

  6. Open Source Projects in Software Engineering Education: A Mapping Study

    ERIC Educational Resources Information Center

    Nascimento, Debora M. C.; Almeida Bittencourt, Roberto; Chavez, Christina

    2015-01-01

    Context: It is common practice in academia to have students work with "toy" projects in software engineering (SE) courses. One way to make such courses more realistic and reduce the gap between academic courses and industry needs is getting students involved in open source projects (OSP) with faculty supervision. Objective: This study…

  7. Communicating the Open Access Message: A Case Study from Ireland

    ERIC Educational Resources Information Center

    Lawton, Aoife

    2016-01-01

    Since 2009, Open Access (OA) Week has been celebrated worldwide in October each year. It is an opportunity for librarians to engage with the research community and demonstrate the value that they bring to their organisations in the area of disseminating scholarly output. Although thousands of events have been held since the inception of OA Week, a…

  8. OpenCourseWare Resources for Advanced High School Study

    ERIC Educational Resources Information Center

    Carson, Steve

    2008-01-01

    In 2000, the Massachusetts Institute of Technology (MIT) faculty first proposed putting the course materials from all 1,800 MIT classes online, free of charge. The idea behind MIT OpenCourseWare (OCW) was to use the Internet for more than just distance learning. When MIT began placing the course materials online in 2002 and 2003, the audience…

  9. Open Source Projects in Software Engineering Education: A Mapping Study

    ERIC Educational Resources Information Center

    Nascimento, Debora M. C.; Almeida Bittencourt, Roberto; Chavez, Christina

    2015-01-01

    Context: It is common practice in academia to have students work with "toy" projects in software engineering (SE) courses. One way to make such courses more realistic and reduce the gap between academic courses and industry needs is getting students involved in open source projects (OSP) with faculty supervision. Objective: This study…

  10. Communicating the Open Access Message: A Case Study from Ireland

    ERIC Educational Resources Information Center

    Lawton, Aoife

    2016-01-01

    Since 2009, Open Access (OA) Week has been celebrated worldwide in October each year. It is an opportunity for librarians to engage with the research community and demonstrate the value that they bring to their organisations in the area of disseminating scholarly output. Although thousands of events have been held since the inception of OA Week, a…

  11. OpenCourseWare Resources for Advanced High School Study

    ERIC Educational Resources Information Center

    Carson, Steve

    2008-01-01

    In 2000, the Massachusetts Institute of Technology (MIT) faculty first proposed putting the course materials from all 1,800 MIT classes online, free of charge. The idea behind MIT OpenCourseWare (OCW) was to use the Internet for more than just distance learning. When MIT began placing the course materials online in 2002 and 2003, the audience…

  12. Colloidal α-Al2O3 Europium(III) and humic substances interactions: a macroscopic and spectroscopic study.

    PubMed

    Janot, Noémie; Benedetti, Marc F; Reiller, Pascal E

    2011-04-15

    Eu(III) sorption onto α-Al(2)O(3) in the presence of purified Aldrich humic acid (PAHA) is studied by batch experiments and time-resolved laser-induced luminescence spectroscopy of Eu(III). Experiments are conducted at varying pH, at 0.1 mol/L NaClO(4), 10(-6) mol/L Eu(III), 1 g/L α-Al(2)O(3) and 28 mg/L PAHA, which assured a complete Eu(III)-PAHA complexation. Adsorption of Eu(III) presents the expected pH-edge at 7, which is modified by addition of PAHA. Presence of Eu(III) slightly increases PAHA sorption throughout the pH range. The evolutions of luminescence spectra and decay times of the binary systems, that is, Eu(III)/α-Al(2)O(3) and Eu(III)/PAHA, indicate a progressive surface- and humic-complexation with increasing pH. The typical biexponential luminescence decay in Eu(III)/PAHA system is also recorded; the fastest deactivation depending barely on pH. In ternary Eu(III)/PAHA/α-Al(2)O(3) system, the existence of a luminescence biexponential decay for all pH means that Eu(III) is always in the direct neighborhood of the humic substance. Below pH 7, the spectra of the ternary system (Eu(III)/PAHA/α-Al(2)O(3)) are not different from the ones of Eu(III)/PAHA system, implying the same complex symmetry. Nevertheless, the increase of luminescence decay time points to a change in PAHA conformation onto the surface.

  13. Thermodynamic and Spectroscopic Studies of Lanthanides(III) Complexation with Polyamines in Dimethyl Sulfoxide

    SciTech Connect

    Di Bernardo, Plinio; Zanonato, Pier Luigi; Melchior, Andrea; Portanova, Roberto; Tolazzi, Marilena; Choppin, Gregory R.; Wang, Zheming

    2008-01-01

    The thermodynamic parameters of complexation of Ln(III) cations with tris(2-aminoethyl)amine (tren) and tetraethylenepentamine (tetren) were determined in dimethyl sulfoxide (DMSO) by potentiometry and calorimetry. The excitation and emission spectra and luminescence decay constants of Eu3+ and Tb3+ complexed by tren and tetren, as well as those of the same lanthanides(III) complexed with diethylenetriamine (dien) and triethylenetetramine (trien), were also obtained in the same solvent. The combination of thermodynamic and spectroscopic data showed that, in the 1:1 complexes, all nitrogens of the ligands bound to the lanthanides except in the case of tren, in which only pendant N bound. For the larger ligands (trien, tren, tetren) in the higher complexes (ML2), there was less complete binding by available donors, presumably due to steric crowding. FT-IR studies were carried out in an acetonitrile/DMSO mixture, suitably chosen in order to follow the changes in the primary solvation sphere of lanthanide(III) due to complexation of amine ligands. Results show that the mean number of molecules of DMSO removed from the inner coordination sphere of lanthanides(III) is lower than ligand denticity and that the coordination number of the metal ions increases with amine complexation from ~8 to ~10. Independently of the number and structure of the amines, linear trends, similar for all lanthanides, were obtained by plotting the values of ΔGj°, ΔHj° and TΔSj° for the complexation of ethylenediamine (en), dien, trien, tren and tetren as a function of the number of amine metal-coordinated nitrogen atoms. The main factors on which the thermodynamic functions of lanthanide(III) complexation reactions in DMSO depend are discussed.

  14. Solvation of Co(III)-cysteinato complexes in water: a DFT-based molecular dynamics study.

    PubMed

    Spezia, Riccardo; Bresson, Carole; Den Auwer, Christophe; Gaigeot, Marie-Pierre

    2008-05-22

    Structural, dynamical, and vibrational properties of complexes made of metal cobalt(III) coordinated to different amounts of cysteine molecules were investigated with DFT-based Car-Parrinello molecular dynamics (CPMD) simulations in liquid water solution. The systems are composed of Co(III):3Cys and Co(III):2Cys immersed in liquid water which are modeled by about 110 explicit water molecules, thus one of the biggest molecular systems studied with ab initio molecular simulations so far. In such a way, we were able to investigate structural and dynamical properties of a model of a typical metal binding site used by several proteins. Cobalt, mainly a toxicological agent, can replace the natural binding metal and thus modify the biochemical activity. The structure of the surrounding solvent around the metal-ligands complexes is reported in detail, as well as the metal-ligands coordination bonds, using radial distribution functions and electronic analyses with Mayer bond orders. Structures of the Cocysteine complexes are found in very good agreement with EXAFS experimental data, stressing the importance of considering the surrounding solvent in the modeling. A vibrational analysis is also conducted and compared to experiment, which strengthens the reliability of the solvent interactions with the Cocysteine complexes from our molecular dynamics simulations, as well as the dynamics of the systems. From this preliminary analysis, we could suggest a vibrational fingerprint able to distinguish Co(III):2Cys from Co(III):3Cys. Our simulations also show the importance of considering a quantum explicit solvent, as solute-to-solvent proton transfer events have been observed.

  15. Classroom Interaction in Effective and Ineffective Schools: Preliminary Results from Phase III of the Louisiana School Effectiveness Study

    ERIC Educational Resources Information Center

    Stringfield, Samuel; Teddlie, Charles; Suarez, Sandra

    2017-01-01

    A major focus in Phase III of the Louisiana School Effectiveness Study is on the relationship between classroom interaction patterns and school effectiveness. This paper presents observations on similarities and differences between prior teacher and school effectiveness studies, the LSES-III methodology, and preliminary results from one of the…

  16. Positron annihilation studies of defects in molecular beam epitaxy grown III-V layers

    SciTech Connect

    Umlor, M.T.; Keeble, D.J.; Asoka-Kumar, P.; Lynn, K.G.; Cooke, P.W.

    1994-08-01

    A summary of recent positron annihilation experiments on molecular beam epitaxy (MBE) grown III-V layers is Presented. Variable energy positron beam measurements on Al{sub 0.32}Ga{sub 0.68}As undoped and Si doped have been completed. Positron trapping at a open volume defect in Al{sub 0.32}Ga{sub 0.68}:Si for temperatures from 300 to 25 K in the dark was observed. The positron trap was lost after 1.3 eV illumination at 25K. These results indicate an open volume defect is associated with the local structure of the deep donor state of the DX center. Stability of MBE GaAs to thermal annealing war, investigated over the temperature range of 230 to 700{degrees}C, Proximity wafer furnace anneals in flowing argon were used, Samples grown above 450{degrees}C were shown to be stable but for sample below this temperature an anneal induced vacancy related defect was produced for anneals between 400 and 500{degrees}C. The nature of the defect was shown to be different for material grown at 350 and 230{degrees}C. Activation energies of 2.5 eV to 2.3 eV were obtained from isochronal anneal experiments for samples grown at 350 and 230{degrees}C, respectively.

  17. The death of a mind: a study of Shakespeare's Richard III.

    PubMed

    Anderson, Maxine K

    2006-11-01

    Some of the most difficult aspects of our work involve our encounters with states of mind which are steeped in and spread violence. In these circumstances, we experience our best efforts to offer empathic presence and thought to avoid being assaulted and obliterated. In these instances, a figure from literature depicting the details in question may come to our aid. In the play popularly known as Richard III,William Shakespeare depicts how the state of mind which is etched by grievance and committed to revenge may impose the 'winter of (its) discontent' upon the sunny dispositions of others' healthy, integrated functioning. Shakespeare masterfully depicts Richard's cunning and malice, but he also illustrates how this vengeful state uses guile and 'changes of shape' to seduce its way past protective boundaries, utilizing the human qualities of trust, open-heartedness and longing as pathways for invasion, betrayal and emotional devastation. This paper will view excerpts of the play's text from a psychoanalytic perspective which suggests that several clear lessons about this obliterative state of mind may be gleaned: that grievance can only operate to spread grievance and destruction; that our open-hearted and trusting qualities do make us vulnerable to such invasion and betrayal, but that our humanity is also the only avenue for rescue from this plight. In addition a clear lesson is offered about the value of protected 'sanctuary', that is, mental space where our most potent tool in these circumstances, our discerning minds, might find residence.

  18. Complexation Studies of Bidentate Heterocyclic N-Donor Ligands with Nd(III) and Am(III)

    SciTech Connect

    Ogden, Mark; Hoch, Courtney L.; Sinkov, Sergey I.; Meier, Patrick; Lumetta, Gregg J.; Nash, Kenneth L.

    2011-11-28

    A new bidentate nitrogen donor complexing agent that combines pyridine and triazole functional groups, 2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)pyridine (PTMP), has been synthesized. The strength of its complexes with trivalent americium (Am3+) and neodymium (Nd3+) in anhydrous methanol has been evaluated using spectrophotometric techniques. The purpose of this investigation is to assess this ligand (as representative of a class of similarly structured species) as a possible model compound for the challenging separation of trivalent actinides from lanthanides. This separation, important in the development of advanced nuclear fuel cycles, is best achieved through the agency of multidentate chelating agents containing some number of nitrogen or sulfur donor groups. To evaluate the relative strength of the bidentate complexes, the derived constants are compared to those of the same metal ions with 2,2*-bipyridyl (bipy), 1,10-phenanthroline (phen), and 2-pyridin-2-yl-1H-benzimidazole (PBIm). At issue is the relative affinity of the triazole moiety for trivalent f element ions. For all ligands, the derived stability constants are higher for Am3+ than Nd3+. In the case of Am3+ complexes with phen and PBIm, the presence of 1:2 (AmL2) species is indicated. Possible separations are suggested based on the relative stability and stoichiometry of the Am3+ and Nd3+ complexes. It can be noted that the 1,2,3-triazolyl group imparts a potentially useful selectivity for trivalent actinides (An(III)) over trivalent lanthanides (Ln(III)), though the attainment of higher complex stoichiometries in actinide compared with lanthanide complexes may be an important driver for developing successful separations.

  19. Growth of cerium(III)-doped ADP crystals and characterization studies

    NASA Astrophysics Data System (ADS)

    Vanchinathan, K.; Muthu, K.; Bhagavannarayana, G.; Meenakshisundaram, SP.

    2012-09-01

    Single crystals of Ce(III)-doped ammonium dihydrogen phosphate (ADP) are grown by conventional slow evaporation of aqueous solution and Sankaranarayanan-Ramasamy (SR) technique. High-resolution X-ray diffraction (HRXRD) studies reveal that the crystalline perfection is substantially better in the case of SR-grown crystal. Morphological changes are observed in the doped specimen. Doping has some influence on the DRS spectra and the band gap energy is estimated by Kubelka-Munk algorithm. Lattice parameters are determined by single crystal XRD analysis. The powder X-ray diffraction and FT-IR analyses indicate that the crystal undergoes considerable stress as a result of doping. The incorporation of Ce(III) into the crystalline matrix of ADP is confirmed by energy dispersive X-ray spectroscopy (EDS). Thermal studies reveal no decomposition up to the melting point and no significant changes are observed as a result of foreign ion incorporation in ADP crystalline matrix.

  20. Comparison of pure laparoscopic versus open left hemihepatectomy by multivariate analysis: a retrospective cohort study.

    PubMed

    Cho, Hwui-Dong; Kim, Ki-Hun; Hwang, Shin; Ahn, Chul-Soo; Moon, Deok-Bog; Ha, Tae-Yong; Song, Gi-Won; Jung, Dong-Hwan; Park, Gil-Chun; Lee, Sung-Gyu

    2017-07-21

    To compare the outcomes of pure laparoscopic left hemihepatectomy (LLH) versus open left hemihepatectomy (OLH) for benign and malignant conditions using multivariate analysis. All consecutive cases of LLH and OLH between October 2007 and December 2013 in a tertiary referral hospital were enrolled in this retrospective cohort study. All surgical procedures were performed by one surgeon. The LLH and OLH groups were compared in terms of patient demographics, preoperative data, clinical perioperative outcomes, and tumor characteristics in patients with malignancy. Multivariate analysis of the prognostic factors associated with severe complications was then performed. The LLH group (n = 62) had a significantly shorter postoperative hospital stay than the OLH group (n = 118) (9.53 ± 3.30 vs 14.88 ± 11.36 days, p < 0.001). Multivariate analysis revealed that the OLH group had >4 times the risk of the LLH group in terms of developing severe complications (Clavien-Dindo grade ≥III) (odds ratio 4.294, 95% confidence intervals 1.165-15.832, p = 0.029). LLH was a safe and feasible procedure for selected patients. LLH required shorter hospital stay and resulted in less operative blood loss. Multivariate analysis revealed that LLH was associated with a lower risk of severe complications compared to OLH. The authors suggest that LLH could be a reasonable treatment option for selected patients.

  1. Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes.

    PubMed

    Obasi, Lawrence Nnamdi; Oruma, Uchechukwu Susan; Al-Swaidan, Ibrahim Abdulrazak; Ramasami, Ponnadurai; Ezeorah, Chigozie Julius; Ochonogor, Alfred Ezinna

    2017-02-22

    N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, ¹H- and (13)C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III) complex displays a coordination number of eight while thallium(III) complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities against Escherichia coli strains (E. coli 6 and E. coli 13), Proteus species, Staphylococcus aureus and Pseudomonas aeruginosa using the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole.

  2. Efficacy and safety of oral iron(III) polymaltose complex versus ferrous sulfate in pregnant women with iron-deficiency anemia: a multicenter, randomized, controlled study.

    PubMed

    Ortiz, Ricardo; Toblli, Jorge Eduardo; Romero, Juan Diego; Monterrosa, Beatriz; Frer, Cristina; Macagno, Eugenia; Breymann, Christian

    2011-11-01

    To evaluate the efficacy and safety of iron(III) polymaltose complex (Maltofer(®)) versus ferrous sulfate in iron-deficient pregnant women using recommended doses. An exploratory, open-label, randomized, controlled, multicenter study was undertaken in 80 pregnant women with iron-deficiency anemia (hemoglobin ≤ 10.5 g/dL, serum ferritin ≤ 15 ng/mL and mean corpuscular volume < 80 fL). Patients were randomized 1:1 to oral iron(III) polymaltose complex or ferrous sulfate (each 100 mg iron twice daily) for 90 days. The primary endpoint, change in hemoglobin from baseline to days 60 and 90, did not differ significantly between treatment groups. The mean (SD) change to day 90 was 2.16 (0.67) g/dL in the iron(III) polymaltose complex group and 1.93 (0.97) g/dL in the ferrous sulfate group (n.s). Mean serum ferritin at day 90 was 179 (38) ng/mL and 157 (34) ng/mL with iron(III) polymaltose complex and ferrous sulfate, respectively (p = 0.014). Adverse events were significantly less frequent in the iron(III) polymaltose group, occurring in 12/41 (29.3%) patients, than in the ferrous sulfate group (22/39 [56.4%]) (p = 0.015). Oral iron(III) polymaltose complex offers at least equivalent efficacy and a superior safety profile compared to ferrous sulfate for the treatment of iron-deficiency anemia during pregnancy.

  3. [Study of chemical constituents in active parts of Mentha spicata III].

    PubMed

    Chen, Guang-Tong; Gao, Hui-Yuan; Zheng, Jian; Wu, Bin; Yang, Xiao-Ke; Wu, Li-Jun

    2006-04-01

    To study the chemical constituents of Mentha spicata. The chemical constituents were isolated by silica gel column chromatography, and identified by physical and chemical characters and spectroscopic analysis. Compounds I - V were obtained and their structures were elucidated as protocatechuic aldehyde (I), protocatechuic acid (II), chrysoeriol (III), 5, 6-dihydroxy-7, 8, 3', 4'-tetramethoxyflavone (IV), nodifloretin (V). Compound I and II were first isolated from the genus Mentha. Compound Ill, IV and V were isolated from M. spicata for the first time.

  4. Structural studies of lanthanide(III) 1,2-ethylene-diphosphonic acid complexes

    SciTech Connect

    McIlwraith, H.; Zhang, J.; Rogers, R.D.

    1995-12-31

    1,2-Ethylenediphosphonic acid can be classified in a class of extractants known as thermally unstable complexants (TUCS). Extraction accomplished using TUCS ligands can be followed by thermal degradation of the extractant. Despite their proposed utility in separation, few structures of lanthanide(III)/TUCS complexes are known. Structural studies can help us to understand the extraction mechanism and the interaction between metal ions and the ligand.

  5. Numerical study of natural convection in fully open tilted cavities

    SciTech Connect

    Elsayed, M.M.; Al-Najem, N.M.; El-Refaee, M.M.; Noor, A.A.

    1999-09-01

    A numerical simulation of two-dimensional laminar natural convection in a fully open tilted square cavity with an isothermally heated back wall is conducted. The remaining two walls of the cavity are adiabatic. Steady-state solutions are presented for Grashof numbers between 10{sup 2} and 10{sup 5} and for tilt angles ranging from {minus}60{degree} to 90{degree} (where 90{degree} represents a cavity with the opening facing down). The fluid properties are assumed to be constant except for the density variation with temperature that gives rise to the buoyancy forces, which is treated by the Boussinesq approximation. The fluid concerned is air with Prandtl number fixed at 0.71. The governing equations are expressed in a normalized primitive variables formulation. Numerical predictions of the velocity and temperature fields are obtained using the finite-volume-based power law (SIMPLER: Semi-Implicit Method for Pressure-Linked Equations Revised) algorithm. For a vertical open cavity ({alpha} = 0{degree}), the algorithm generated results that were in good agreement with those previously published. Flow patterns and isotherms are shown in order to give a better understanding of the heat transfer and flow mechanisms inside the cavity. Effects of the controlling parameters-Grashof number and tilt angle-on the heat transfer (average Nusselt number) are presented and analyzed. The results also revealed that the open-cavity Nusselt number approaches the flat-plate solution when either Grashof number or tilt angle increases. In addition, a correlation of the Nusselt number in terms of the Grashof number and tilt angle is developed and presented; a comparison is made with available data from other literature.

  6. Stereotactic radiosurgery for Spetzler-Martin Grade III arteriovenous malformations: an international multicenter study.

    PubMed

    Ding, Dale; Starke, Robert M; Kano, Hideyuki; Lee, John Y K; Mathieu, David; Pierce, John; Huang, Paul P; Feliciano, Caleb; Rodriguez-Mercado, Rafael; Almodovar, Luis; Grills, Inga S; Silva, Danilo; Abbassy, Mahmoud; Missios, Symeon; Kondziolka, Douglas; Barnett, Gene H; Lunsford, L Dade; Sheehan, Jason P

    2017-03-01

    OBJECTIVE Because of the angioarchitectural diversity of Spetzler-Martin (SM) Grade III arteriovenous malformations (AVMs), the management of these lesions is incompletely defined. The aims of this multicenter, retrospective cohort study were to evaluate the outcomes after stereotactic radiosurgery (SRS) for SM Grade III AVMs and to determine the factors predicting these outcomes. METHODS The authors analyzed and pooled data from patients with SM Grade III AVMs treated with SRS at 8 institutions participating in the International Gamma Knife Research Foundation. Patients with these AVMs and a minimum follow-up length of 12 months were included in the study cohort. An optimal outcome was defined as AVM obliteration, no post-SRS hemorrhage, and no permanently symptomatic radiation-induced changes (RICs). Data were analyzed by univariate and multivariate regression analyses. RESULTS The SM Grade III AVM cohort comprised 891 patients with a mean age of 34 years at the time of SRS. The mean nidus volume, radiosurgical margin dose, and follow-up length were 4.5 cm(3), 20 Gy, and 89 months, respectively. The actuarial obliteration rates at 5 and 10 years were 63% and 78%, respectively. The annual postradiosurgery hemorrhage rate was 1.2%. Symptomatic and permanent RICs were observed in 11% and 4% of the patients, respectively. Optimal outcome was achieved in 56% of the patients and was significantly more frequent in cases of unruptured AVMs (OR 2.3, p < 0.001). The lack of a previous hemorrhage (p = 0.037), absence of previous AVM embolization (p = 0.002), smaller nidus volume (p = 0.014), absence of AVM-associated arterial aneurysms (p = 0.023), and higher margin dose (p < 0.001) were statistically significant independent predictors of optimal outcome in a multivariate analysis. CONCLUSIONS Stereotactic radiosurgery provided better outcomes for patients with small, unruptured SM Grade III AVMs than for large or ruptured SM Grade III nidi. A prospective trial or registry

  7. ERA's Open Rotor Studies Including Shielding for Noise Reduction

    NASA Technical Reports Server (NTRS)

    Van Zante, Dale; Thomas, Russell

    2012-01-01

    The Open Rotor is a modern version of the UnDucted Fan (UDF) that was flight tested in the late 1980's through a partnership between NASA and General Electric (GE). Tests were conducted in the 9' x 15' Low Speed Wind Tunnel and the 8' x 6' Supersonic Wind Tunnel starting in late 2009 and completed in early 2012. Aerodynamic and acoustic data were obtained for takeoff, approach and cruise simulations. GE was the primary partner, but other organizations were involved such as Boeing and Airbus who provided additional hardware for fuselage simulations. This test campaign provided the acoustic and performance characteristics for modern open rotor blades designs." NASA and GE conducted joint systems analysis to evaluate how well new blade designs would perform on a B737 class aircraft, and compared the results to an advanced higher bypass ratio turbofan." Acoustic shielding experiments were performed at NASA GRC and Boeing LSAF facilities to provide data for noise estimates of unconventional aircraft configurations with Open Rotor propulsion systems." The work was sponsored by NASA's aeronautics programs, including the Subsonic Fixed Wing (SFW) and the Environmentally Responsible Aviation (ERA) projects."

  8. Subcellular Relocalization and Positive Selection Play Key Roles in the Retention of Duplicate Genes of Populus Class III Peroxidase Family[W][OPEN

    PubMed Central

    Ren, Lin-Ling; Liu, Yan-Jing; Liu, Hai-Jing; Qian, Ting-Ting; Qi, Li-Wang; Wang, Xiao-Ru; Zeng, Qing-Yin

    2014-01-01

    Gene duplication is the primary source of new genes and novel functions. Over the course of evolution, many duplicate genes lose their function and are eventually removed by deletion. However, some duplicates have persisted and evolved diverse functions. A particular challenge is to understand how this diversity arises and whether positive selection plays a role. In this study, we reconstructed the evolutionary history of the class III peroxidase (PRX) genes from the Populus trichocarpa genome. PRXs are plant-specific enzymes that play important roles in cell wall metabolism and in response to biotic and abiotic stresses. We found that two large tandem-arrayed clusters of PRXs evolved from an ancestral cell wall type PRX to vacuole type, followed by tandem duplications and subsequent functional specification. Substitution models identified seven positively selected sites in the vacuole PRXs. These positively selected sites showed significant effects on the biochemical functions of the enzymes. We also found that positive selection acts more frequently on residues adjacent to, rather than directly at, a critical active site of the enzyme, and on flexible regions rather than on rigid structural elements of the protein. Our study provides new insights into the adaptive molecular evolution of plant enzyme families. PMID:24934172

  9. X-ray diffraction, FTIR, UV-VIS and SEM studies on chromium (III) complexes

    SciTech Connect

    Mishra, Ashutosh; Dwivedi, Jagrati Shukla, Kritika

    2015-06-24

    Five Chromium (III) complexes have been prepared using Schiff base ligands which derived from benzoin and five different amino acids (H{sub 2}N-R). Samples were characterized by XRD, FTIR, UV-VIS and SEM method. X-Ray diffraction pattern analyzed that all chromium (III) complexes have hexagonal structure and crystalline, in nature, using Bruker D8 Advance instrument. Using VERTAX 70, FTIR spectroscopy reveals that Samples have (C=N), (C-O), (M-N) and (M-O) bonds in the range of 4000-400cm{sup −1}. UV-VIS spectroscopy give information that samples absorb the visible light which is in the range of 380-780nm. For this, Lambda 960 spectrometer used. SEM is designed for studying of the solid objects, using JEOL JSM 5600 instrument.

  10. Synthesis, characterization and antibacterial study of cyclometalated rhodium(III) complex containing dithiocarbamate

    NASA Astrophysics Data System (ADS)

    Mansouri, Ghobad; Heidarizadi, Fateme; Naghipour, Ali; Notash, Behrouz

    2016-10-01

    The novel cyclometalated Rh(III) complex, [Rh(phpy)2(SˆS)], Where phpy is 2-phenylpyridine and (SˆS) is diethyldithiocarbamate, has been prepared and characterized by elemental analysis, IR, 13C and 1H NMR, electronic absorption and Fluorescence spectroscopies, cyclic voltammetry, and X-ray crystallography. The crystal structure of [Rh(phpy)2(SˆS)] shows that the coordination geometry around the Rh(III) is a distorted octahedron, with bite angles of 71.19-81.04° for all three bidentate ligands. Electrochemical analysis by cyclic voltammetry reveals irreversible redox behavior of the rhodium centre. Antibacterial activity of the complex has also been studied by agar disc diffusion method against three Gram-negative bacteria (Pseudomonas aeroginosa, Salmonella typhi and Escherichia coli) and two Gram-positive bacteria (Staphylococcus aureus and Corynebacterium renale).

  11. Study of the thermodynamics of chromium(III) and chromium(VI) binding to iron(II/III)oxide or magnetite or ferrite and magnanese(II) iron (III) oxide or jacobsite or manganese ferrite nanoparticles.

    PubMed

    Luther, Steven; Brogfeld, Nathan; Kim, Jisoo; Parsons, J G

    2013-06-15

    Removal of chromium(III) or (VI) from aqueous solution was achieved using Fe3O4, and MnFe2O4 nanomaterials. The nanomaterials were synthesized using a precipitation method and characterized using XRD. The size of the nanomaterials was determined to be 22.4±0.9 nm (Fe3O4) and 15.5±0.5 nm (MnFe2O4). The optimal binding pH for chromium(III) and chromium(VI) were pH 6 and pH 3. Isotherm studies were performed, under light and dark conditions, to determine the capacity of the nanomaterials. The capacities for the light studies with MnFe2O4 and Fe3O4 were determined to be 7.189 and 10.63 mg/g, respectively, for chromium(III). The capacities for the light studies with MnFe2O4 and Fe3O4 were 3.21 and 3.46 mg/g, respectively, for chromium(VI). Under dark reaction conditions the binding of chromium(III) to the MnFe2O4 and Fe3O4 nanomaterials were 5.74 and 15.9 mg/g, respectively. The binding capacity for the binding of chromium(VI) to MnFe2O4 and Fe3O4 under dark reaction conditions were 3.87 and 8.54 mg/g, respectively. The thermodynamics for the reactions showed negative ΔG values, and positive ΔH values. The ΔS values were positive for the binding of chromium(III) and for chromium(VI) binding under dark reaction conditions. The ΔS values for chromium(VI) binding under the light reaction conditions were determined to be negative.

  12. Theoretical and spectroscopic studies of pyridyl substituted bis-coumarins and their new neodymium (III) complexes

    NASA Astrophysics Data System (ADS)

    Kostova, Irena; Trendafilova, Natasha; Mihaylov, Tzvetan

    2005-07-01

    Ab initio, DFT and spectroscopic studies of 3,3'-( o-pyridinomethylene)di-[4-hydroxycoumarin], 3,3'-( m-pyridinomethylene)di-[4-hydroxycoumarin] and 3,3'-( p-pyridinomethylene)di-[4-hydroxycoumarin] were performed. The molecular and electronic structures of the compounds were investigated using accurate HF and B3LYP/6-31G(d) calculations. Molecular quantities as vertical ionization potential, electron affinity, electronegativity, hardness and electrophilicity indices of the neutral species were calculated and discussed. Molecular electrostatic potential was considered as an additional molecular characteristic for predicting the most probable sites for electrophilic attack. The molecular structure and quantities of the dianionic species, which are active in solution, were calculated and discussed. The theoretical results suggested that both carbonyl and both hydroxyl oxygen atoms are preferred binding sites for electrophilic attack, in particular for a metal coordination. Further, the coordination abilities of the compounds were studied in complexation reactions with Nd(III). Complexes of Nd(III) with o-, m- and p-3,3'-(pyridinomethylene)di-[4-hydroxycoumarin] were synthesized and characterized by different physicochemical methods: elemental analysis, IR, 1H NMR spectroscopies and mass spectral data. The experimental data confirmed the theoretical predictions that the ligands in Nd(III) complexes are tetradentate and bound the metal ion through both carbonyl and both deprotonated hydroxyl oxygen atoms.

  13. Mononuclear Ru(III) Schiff base complexes: Synthesis, spectral, redox, catalytic and biological activity studies

    NASA Astrophysics Data System (ADS)

    Priya, N. Padma; Arunachalam, S.; Manimaran, A.; Muthupriya, D.; Jayabalakrishnan, C.

    2009-04-01

    An octahedral ruthenium(III) Schiff base complexes of the type [RuX(EPh 3)(L)] (where, X = Cl/Br; E = As/P; L = dianion of the Schiff bases derived from acetoacetanilide with o-phenylenediamine and salicylaldehyde/ o-hydroxyacetophenone/ o-vanillin/2-hydroxy-1-naphthaldehyde) have been synthesized from the reactions of equimolar reactions of [RuX 3(EPh 3) 3] and Schiff bases in benzene. The new Ru(III) Schiff base complexes have been characterized by elemental analyses, FT-IR, electronic, 1H NMR and 13C NMR spectra, EPR spectral studies, powder X-ray diffraction (XRD) and electrochemical studies. The new complexes were found to be effective catalysts for aryl-aryl coupling and the oxidation of alcohols into their corresponding carbonyl compounds, respectively, using molecular oxygen atmosphere at ambient temperature. Further, the new Ru(III) Schiff base complexes were screened for their antibacterial activity against Pseudomonas aeruginosa, Vibrio cholera, Salomonella typhi and Staphylococcus aureaus.

  14. 17O NMR study of diamagnetic and paramagnetic lanthanide(III)-DOTA complexes in aqueous solution.

    PubMed

    Fusaro, Luca; Luhmer, Michel

    2014-08-18

    The complexes between the polyaminocarboxylate DOTA ligand and the whole series of stable lanthanide(III) metal ions, except Gd(3+), were studied in aqueous solution by (17)O NMR. For all of the paramagnetic systems, the (17)O NMR signals of both the nonchelating (O1) and chelating (O2) oxygen atoms could be detected, and for some of them, the signals of both the SAP and TSAP (TSAP') conformational isomers were also observed. Line width data analysis reveals that signal broadening is not dominated by paramagnetic relaxation enhancement, as it was believed to be. The data indicate that quadrupole relaxation and, for some complexes, chemical exchange between the SAP and TSAP isomers are the major contributions to the (17)O NMR line width at 25 °C. Besides, the Fermi contact and pseudocontact contributions to the observed lanthanide-induced shifts could be extracted. The (17)O hyperfine coupling constants determined for O2 in the SAP and TSAP isomers are similar to each other and to the values reported for several Gd(III) complexes comprising fast-exchanging ligands. Interestingly, the results suggest that (17)O NMR should prove to be useful for the study of highly paramagnetic Gd(III) complexes of nonlabile ligands.

  15. Characterization of microbially Fe(III)-reduced nontronite: Environmental cell-transmission electron microscopy study

    USGS Publications Warehouse

    Kim, J.-W.; Furukawa, Y.; Daulton, T.L.; Lavoie, D.; Newell, S.W.

    2003-01-01

    Microstructural changes induced by the microbial reduction of Fe(III) in nontronite by Shewanella oneidensis were studied using environmental cell (EC)-transmission electron microscopy (TEM), conventional TEM, and X-ray powder diffraction (XRD). Direct observations of clays by EC-TEM in their hydrated state allowed for the first time an accurate and unambiguous TEM measurement of basal layer spacings and the contraction of layer spacing caused by microbial effects, most likely those of Fe(III) reduction. Non-reduced and Fe(III)-reduced nontronite, observed by EC-TEM, exhibited fringes with mean d001 spacings of 1.50 nm (standard deviation, ?? = 0.08 nm) and 1.26 nm (?? = 0.10 nm), respectively. In comparison, the same samples embedded with Nanoplast resin, sectioned by microtome, and observed using conventional TEM, displayed layer spacings of 1.0-1.1 nm (non-reduced) and 1.0 nm (reduced). The results from Nanoplast-embedded samples are typical of conventional TEM studies, which have measured nearly identical layer spacings regardless of Fe oxidation state. Following Fe(III) reduction, both EC- and conventional TEM showed an increase in the order of nontronite selected area electron diffraction patterns while the images exhibited fewer wavy fringes and fewer layer terminations. An increase in stacking order in reduced nontronite was also suggested by XRD measurements. In particular, the ratio of the valley to peak intensity (v/p) of the 1.7 nm basal 001 peak of ethylene glycolated nontronite was measured at 0.65 (non-reduced) and 0.85 (microbially reduced).

  16. Clobetasol propionate emulsion formulation foam 0.05%: review of phase II open-label and phase III randomized controlled trials in steroid-responsive dermatoses in adults and adolescents.

    PubMed

    Kimball, Alexa Boer; Gold, Michael H; Zib, Beth; Davis, Mark W

    2008-09-01

    Clobetasol propionate 0.05% emulsion foam was recently developed for use on multiple body sites. We sought to evaluate safety and efficacy of clobetasol emulsion foam 0.05% to treat steroid-responsive dermatoses in multiple age groups. A phase II open-label study evaluated the effect of clobetasol foam on the hypothalamic-pituitary-adrenal axis in 52 participants aged 6 years or older with mild-to-severe atopic dermatitis (AD). Cosyntropin stimulation test was used to determine the effect of clobetasol foam on hypothalamic-pituitary-adrenal axis, with a normal response considered to be a postinjection serum cortisol level greater than 18 mug/dL. Another phase II open-label pharmacokinetic safety study was conducted in 32 participants aged 12 years or older with mild-to-moderate plaque-type psoriasis. Pharmacokinetic parameters evaluated included maximal plasma concentration of clobetasol propionate, time to achieve maximum concentration, and area under the curve. Two phase III, randomized controlled studies assessed treatment success in participants aged 12 years or older with moderate-to-severe AD (N = 377) or mild-to-moderate plaque-type psoriasis (N = 497). In all studies, participants received study drug for 2 weeks. In the AD study, treatment success was determined using a composite end point requiring an Investigator's Static Global Assessment (ISGA) score of 0 or 1, erythema score of 0 or 1, induration/papulation score of 0 or 1, and improvement in the ISGA score of at least two grades from baseline. Likewise, the study in plaque-type psoriasis used a composite end point requiring an ISGA score of 0 or 1, erythema score of 0 or 1, scaling score of 0 or 1, plaque thickness score of 0, and improvement in the ISGA score of at least two grades from baseline. Significantly more participants achieved treatment success on clobetasol foam than vehicle foam (P < .0001 and P = .0005 for each study). Reversible hypothalamic-pituitary-adrenal axis suppression was

  17. Resonance widths in open microwave cavities studied by harmonic inversion.

    PubMed

    Kuhl, U; Höhmann, R; Main, J; Stöckmann, H-J

    2008-06-27

    From the measurement of a reflection spectrum of an open microwave cavity, the poles of the scattering matrix in the complex plane have been determined. The resonances have been extracted by means of the harmonic inversion method. By this, it became possible to resolve the resonances in a regime where the linewidths exceed the mean level spacing up to a factor of 10, a value inaccessible in experiments up to now. The obtained experimental distributions of linewidths were found to be in perfect agreement with predictions from random matrix theory when wall absorption and fluctuations caused by couplings to additional channels are considered.

  18. Relationship between Class III malocclusion and hyoid bone displacement during swallowing: a cine-magnetic resonance imaging study

    PubMed Central

    Gokce, Hasan Suat; Gorgulu, Serkan; Karacay, Seniz; Akca, Eralp; Olmez, Huseyin

    2012-01-01

    Objective The displacement of the hyoid bone (HB) is a critical biomechanical component of the swallowing function. The aim of this study was to evaluate the swallowing-induced vertical and horizontal displacements of the HB in subjects with 2 different magnitudes of skeletal Class III malocclusion, by means of real-time, balanced turbo-field-echo (B-TFE) cine-magnetic resonance imaging. Methods The study population comprised 19 patients with mild skeletal Class III malocclusion, 16 with severe skeletal Class III malocclusion, and 20 with a skeletal Class I relationship. Before the commencement of the study, all subjects underwent cephalometric analysis to identify the nature of skeletal malformations. B-TFE images were obtained for the 4 consecutive stages of deglutition as each patient swallowed 10 mL of water, and the vertical and horizontal displacements of the HB were measured at each stage. Results At all stages of swallowing, the vertical position of the HB in the severe Class III malocclusion group was significantly lower than those in the mild Class III and Class I malocclusion groups. Similarly, the horizontal displacement of the HB was found to be significantly associated with the severity of malocclusion, i.e., the degree of Class III malocclusion, while the amount of anterior displacement of the HB decreased with an increase in the severity of the Class III deformity. Conclusions Our findings indicate the existence of a relationship between the magnitude of Class III malocclusion and HB displacement during swallowing. PMID:23112950

  19. The interaction of phenolic acids with Fe(III) in the presence of citrate as studied by isothermal titration calorimetry.

    PubMed

    Yang, Senpei; Bai, Guangling; Chen, Lingli; Shen, Qun; Diao, Xianmin; Zhao, Guanghua

    2014-08-15

    Under physiological conditions, exogenous chelators such as polyphenols might interact with non-protein bound ferric complexes, such as Fe(III)-citrate. Additionally, Fe(III) and citrate are widely distributed in various fruits and vegetables which are also rich in phenolic acids. In this study, we focus on the interaction between phenolic acids (gallic acid, methyl gallate and protocatechuic acid) and Fe(III) in the presence of excessive citrate by isothermal titration calorimetry (ITC) for thermodynamic studies, and stopped-flow absorption spectrometry for fast kinetic studies. Results reveal that all of these three phenolic acids can bind to the Fe(III) with the same stoichiometry (3:1). Moreover, the binding constants of these three compounds with Fe(III) are greatly dependent on ligand structure, and are much higher than that of Fe(III)-citrate. Based on their stoichiometry and superhigh binding constants, it is most likely that these three phenolic acids can displace the citrate to bind with one iron(III) ion to form a stable octahedral geometric structure, albeit at different rates. These findings shed light on the interaction between phenolic acids and Fe(III) in the presence of citrate under either physiological conditions or in a food system.

  20. Long-term open-label study of pramipexole in patients with primary restless legs syndrome.

    PubMed

    Inoue, Yuichi; Kuroda, Kenji; Hirata, Koichi; Uchimura, Naohisa; Kagimura, Tatsuo; Shimizu, Tetsuo

    2010-07-15

    A phase III, open-label, long-term clinical study was performed to evaluate the safety and efficacy of pramipexole in a cohort of 141 Japanese patients with primary restless legs syndrome (RLS). The patients were started on pramipexole 0.25 mg/day and were subsequently maintained on that dose or switched to 0.125, 0.5, or 0.75 mg/day to achieve optimal efficacy and tolerability. The International Restless Legs Syndrome Study Group Rating Scale for restless legs syndrome (IRLS) score improved from 22.3+/-4.7 at baseline to 11.1+/-7.7 at week 8 and 4.9+/-5.9 at week 52. IRLS responders, defined as patients whose IRLS total score decreased by > or =50% from baseline, accounted for 67.4% at week 12 and 86.6% at week 52. Over 90% of patients were Clinical Global Impression-global improvement (CGI-I) and Patient Global Impression (PGI) responders. The Pittsburgh Sleep Quality Index (PSQI) score decreased from 7.9+/-3.1 at baseline to 4.6+/-2.9 at week 52. Similarly, the Japanese version of the Epworth Sleepiness Scale score decreased from 9.3+/-5.2 to 4.9+/-3.8. Baseline IRLS score < or =20 was significantly associated with a complete IRLS response in this long-term study. Adverse events were typical of nonergot dopamine agonists, mild in intensity, and decreased in frequency as the study progressed. RLS augmentation was not observed. Pramipexole 0.25-0.75 mg/day is efficacious, safe, and well tolerated in patients with RLS. Pramipexole showed good efficacy, particularly in patients with an IRLS total score <20.

  1. Study on the kinetics and mechanism of Am(III) with TODGA

    SciTech Connect

    Zhu, Wen-bin; Ye, Guo-an; Li, Feng-feng; Li, Hui-rong

    2013-07-01

    The removal of minor actinides (mainly Am, Cm and Np) from the high-level waste would remarkably reduce the necessary storage time. Recently developed, a tridentate ligand, N,N,N',N'-tetraoctyl diglycolamide (TODGA), has been identified as one of the most powerful extractants being considered for the partitioning of trivalent actinides and lanthanides. In the present paper, the extraction kinetics behavior of Am(III) in TODGA/n-dodecane-HNO{sub 3} system has been studied, dependent on various parameters such as the stirring speed, the interfacial area, the extractant concentration in n-dodecane, the extracted ions concentration, the acidity of aqueous phase and the temperature. The results show that: the extraction process is controlled by diffusion mode under 130 rpm of stirring speed and by chemical reaction mode above 150 rpm. The extraction rate equation is given in the paper and the apparent extraction rate constant of Am(III) by TODGA/n-dodecane in 170 rpm and at 25 Celsius degrees is k=(24.2±3.4)*10{sup -3} mol{sup -2.18}*L{sup 2.18}*min{sup -1}*cm. The initial extraction rate of Am(III) by TODGA/n-dodecane at 170 r/min and 25 Celsius degrees increases with increasing temperature, and the apparent active energy is calculated to be E{sub a}=(25.94±0.98) kJ/mol.

  2. Kinetic studies of nitrate removal from aqueous solution using granular chitosan-Fe(III) complex.

    PubMed

    Hu, Qili; Chen, Nan; Feng, Chuanping; Zhang, Jing; Hu, Weiwu; Lv, Long

    2016-01-01

    In the present study, a granular chitosan-Fe(III) complex was prepared as a feasible adsorbent for the removal of nitrate from an aqueous solution. There was no significant change in terms of nitrate removal efficiency over a wide pH range of 3-11. Nitrate adsorption on the chitosan-Fe(III) complex followed the Langmuir-Freundlich isotherm model. In order to more accurately reflect adsorption and desorption behaviors at the solid/solution interface, kinetic model I and kinetic model II were proposed to simulate the interfacial process in a batch system. Nitrate adsorption on the chitosan-Fe(III) complex followed the pseudo-first-order kinetic model and kinetic model I. The proposed half-time could provide useful information for optimizing process design. Adsorption and desorption rate constants obtained from kinetic model I and kinetic model II were beneficial to understanding the interfacial process and the extent of adsorption reaction. Kinetic model I and kinetic model II implied that nitrate uptake exponentially approaches a limiting value.

  3. Microwave-optical study of an As(III) derivative of Eco RI methylase

    NASA Astrophysics Data System (ADS)

    Maki, August H.; Tsao, Desiree H. H.

    1991-06-01

    The authors report on the formation of an unusually stable As(III)-thiolate with a single 'high- affinity' cysteine (Cys) of E. coli RI methylase, monitored via its influence on a neighboring tryptophan (Trp) residue in the enzyme structure. The binding was studied by Trp fluorescence quenching, low temperature phosphorescence and triplet state optically detected magnetic resonance (ODMR) of the intrinsic Trp residue(s). The affected Trp is subject to an external heavy atom effect (HAE) from arsenic, quenching its fluorescence and reducing its phosphorescence lifetime from 6 sec to ca. 70 msec. The enzyme high affinity binding site has at least 27 times the affinity for As(III) as does a typical sulfhydryl reagent, HSCH2CONH2. The accessibility of the arsenical to this Cys site was reduced upon formation of the ternary complex methylase-DNA-sinefungin, suggesting a local conformational change in the enzyme when DNA is bound. The enzymatic activity assay of methylase is not affected by the addition of a 1:1 molar ratio of the arsenical to the methylase, but incubation with an excess of As(III) causes complete loss of enzymatic activity. This suggests that the high- affinity Cys residue is not a part of the active site of the enzyme, but the addition of a molar excess of arsenical to the enzyme derivatizes the Cys residue known to be located in the active site.

  4. Effects of Caramel Colour III on the number of blood lymphocytes: a human study on Caramel Colour III immunotoxicity and a comparison of the results with data from rat studies.

    PubMed

    Houben, G F; van Dokkum, W; van Loveren, H; Penninks, A H; Seinen, W; Spanhaak, S; Ockhuizen, T

    1992-05-01

    Administration of the colour additive Ammonia Caramel Colour (Caramel Colour III) to rats has been associated with decreased lymphocyte counts, specifically in rats fed a diet low in vitamin B6. This effect is rapidly reversible and is caused by an imidazole derivative (THI) in Caramel Colour III. In the present paper, the conduct of a human study with Caramel Colour III is outlined and the results of blood lymphocyte counts are presented. No decrease in the number of blood lymphocytes occurred in marginally vitamin B6-deficient humans who consumed Caramel Colour III at the acceptable daily intake level (200 mg/kg body weight/day) for 7 days. These data are discussed in relation to the effects of Caramel Colour III and THI on blood lymphocyte numbers in rats.

  5. Studying Student Motivations in an Astronomy Massive Open Online Class

    NASA Astrophysics Data System (ADS)

    Wenger, Matthew; Impey, Chris David; Buxner, Sanlyn; Formanek, Martin

    2017-01-01

    Massive Open Online Courses (MOOCs) are large-scale, free classes open to anyone around the world and are are part of an educational industry that includes a growing number of universities. Although they resemble formal classes, MOOCs are of interest to instructors and educational researchers because they are unique learning environments where various people--particularly adult learners--learn science. This research project examined learners in an astronomy MOOC in order to better understand the motivations of MOOC learners. Using a well-tested instrument that examines student motivations for learning, we wanted to compare the motivations of MOOC learners to previous results in undergraduate classrooms. Our results show that our MOOC learners scored high in intrinsic motivation, self-efficacy, and self-determination. They differed from learners in traditional formal educational environments by having lower grade and career-related motivations. These results suggest that MOOC learners have characteristics of learners in so called “free-choice” learning environments, similar to other life-long learners.

  6. Mouth opening in patients irradiated for head and neck cancer: a prospective repeated measures study.

    PubMed

    Kamstra, J I; Dijkstra, P U; van Leeuwen, M; Roodenburg, J L N; Langendijk, J A

    2015-05-01

    Aims of this prospective cohort study were (1) to analyze the course of mouth opening up to 48months post-radiotherapy (RT), (2) to assess risk factors predicting decrease in mouth opening, and (3) to develop a multivariable prediction model for change in mouth opening in a large sample of patients irradiated for head and neck cancer. Mouth opening was measured prior to RT (baseline) and at 6, 12, 18, 24, 36, and 48months post-RT. The primary outcome variable was mouth opening. Potential risk factors were entered into a linear mixed model analysis (manual backward-stepwise elimination) to create a multivariable prediction model. The interaction terms between time and risk factors that were significantly related to mouth opening were explored. The study population consisted of 641 patients: 70.4% male, mean age at baseline 62.3years (sd 12.5). Primary tumors were predominantly located in the oro- and nasopharynx (25.3%) and oral cavity (20.6%). Mean mouth opening at baseline was 38.7mm (sd 10.8). Six months post-RT, mean mouth opening was smallest, 36.7mm (sd 10.0). In the linear mixed model analysis, mouth opening was statistically predicted by the location of the tumor, natural logarithm of time post-RT in months (Ln (months)), gender, baseline mouth opening, and baseline age. All main effects interacted with Ln (months). The mean mouth opening decreased slightly over time. Mouth opening was predicted by tumor location, time, gender, baseline mouth opening, and age. The model can be used to predict mouth opening. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. From OCW to MOOC: Deployment of OERs in a Massive Open Online Course. The Experience of Universidad Carlos III de Madrid (UC3M)

    ERIC Educational Resources Information Center

    Fernández, José Vida; Webster, Susan

    2014-01-01

    The emergence of Massive Open Online Courses (MOOCs) is focusing all its attention on open education. There is growing interest in creating MOOCs, which can be done by transferring OCW courses to MOOC format. However, a series of doubts arise regarding the pros and cons implied in this transformation. In this paper we discuss the conclusions…

  8. Complexation of Lactate with Nd(III) and Eu(III) at Variable Temperatures: Studies by Potentiometry, Microcalorimetry, Optical Absorption and Luminescence Spectroscopy

    SciTech Connect

    Tian, Guoxin; Martin, Leigh R.; Rao, Linfeng

    2010-10-01

    Complexation of neodymium(III) and europium(III) with lactate was studied at variable temperatures by potentiometry, absorption spectrophotometry, luminescence spectroscopy and microcalorimetry. Stability constants of three successive lactate complexes (ML{sup 2+}, ML{sup 2+} and ML{sub 3}(aq), where M stands for Nd and Eu, and L stands for lactate) at 10, 25, 40, 55 and 70 C were determined. The enthalpies of complexation at 25 C were determined by microcalorimetry. Thermodynamic data show that the complexation of trivalent lanthanides (Nd{sup 3+} and Eu{sup 3+}) with lactate is exothermic, and the complexation becomes weaker at higher temperatures. Results from optical absorption and luminescence spectroscopy suggest that the complexes are inner-sphere chelate complexes in which the protonated {alpha}-hydroxyl group of lactate participates in the complexation.

  9. Synthesis and physico-chemical studies of cyclometalated heteroleptic iridium(III) complexes.

    PubMed

    Jayabharathi, Jayaraman; Thanikachalam, Venugopal; Srinivasan, Natesan; Jayamoorthy, Karunamoorthy

    2012-07-01

    Phosphorescent studies of 2-arylimidazole heteroleptic cyclometalated iridium(III) complexes with picolinic acid as the ancillary ligand were made. The observed experimental data reveals that these complexes possess dominantly (3)MLCT and (3)π-π* excited states and the solvent shift of these complexes are interpreted by Reichardt-Dimroth and Marcus solvent functions. The results are consistent with prior assignments on the absorption band to a metal-to-ligand charge transfer excited state associated with chelating ligand. Emission kinetic studies exploited that the radiative transition (k(r)), increases with increasing λ(emi). Copyright © 2012 Elsevier B.V. All rights reserved.

  10. Iridium(III) Mediated Reductive Transformation of Closed-Shell Azo-Oxime to Open-Shell Azo-Imine Radical Anion: Molecular and Electronic Structure, Electron Transfer, and Optoelectronic Properties.

    PubMed

    Pramanik, Shuvam; Roy, Sima; Ghorui, Tapas; Ganguly, Sanjib; Pramanik, Kausikisankar

    2016-02-15

    The hydrogen bonded bis azo-oximato [IrCl2(L(NOH))(L(NO))] 2 and its deprotonated form (Et3NH)[IrCl2(L(NO))2] (Et3NH)(+)3(-) have been isolated in the crystalline state by a facile synthetic method. The azo-oxime frameworks in 3(-) have been conveniently transformed to the azo-imine by reduction with NaBH4 or ascorbic acid. Notably, the coordinated azo-imines accept an extra electron thereby furnishing the azo-imine radical anion complex 4. The underlying reductive transformation can be best described by proton-coupled electron transfer (PCET) process. Both the coordinated ligands (azo-oxime) in 3(-) are typically closed-shell monoanion (L(NO-)), but their reduced form (azo-imine) can behave as open-shell monoanion (L(NH•-)) owing to the presence of highly stabilized virtual orbitals. Remarkable enhancement of the π-acidity in azo-imine relative to the precursor azo-oxime has also been reflected from the electrochemical study. The irido complexes display rich optoelectronic properties, and the origin of the transitions has been scrutinized by the TD-DFT method. The molecular geometries of the complexes 2 and 3(-) reveal that the syn orientation of the azo-oximes frameworks is favored because of strong noncovalent H-bonding and π-π stacking interactions. In the course of the reduction of 3(-), the sterically encumbered disposition of the azo-oximes is converted to the relaxed anti form in the transformed azo-imines. Diffraction study reveals the electronic structure of 4 as [Ir(III)Cl2{(L(NH))2(•-)}]. The superior stabilization of the unpaired spin on the ligand array rather than metal has also been substantiated from EPR and DFT studies. Theoretical analysis reveals that the odd electron delocalizes primarily over both the azo-imine moieties ([IrCl2(L(NH•-))(L(NH))] ↔ ([IrCl2(L(NH))(L(NH•-))]) with no apparent contribution from metal, and this type of ligand-centered mixed valency (LCMV) can be best expressed as Robin-Day class III (fully delocalized

  11. A Phase I-II Study of Postoperative Capecitabine-Based Chemoradiotherapy in Gastric Cancer

    SciTech Connect

    Jansen, Edwin; Crosby, Tom D.L.; Dubbelman, Ria; Bartelink, Harry; Verheij, Marcel

    2007-12-01

    Background: The Intergroup 0116 randomized study showed that postoperative 5-fluorouracil-based chemoradiotherapy improved locoregional control and overall survival in patients with gastric cancer. We hypothesized that these results could be improved further by using a more effective, intensified, and convenient chemotherapy schedule. Therefore, this Phase I-II dose-escalation study was performed to determine the maximal tolerated dose and toxicity profile of postoperative radiotherapy combined with concurrent capecitabine. Patients and Methods: After recovery from surgery for adenocarcinoma of the gastroesophageal junction or stomach, all patients were treated with capecitabine monotherapy, 1,000 mg/m{sup 2} twice daily for 2 weeks. After a 1-week treatment-free interval, patients received capecitabine (650-1,000 mg/m{sup 2} orally twice daily 5 days/week) in a dose-escalation schedule combined with radiotherapy on weekdays for 5 weeks. Radiotherapy was delivered to a total dose of 45 Gy in 25 fractions to the gastric bed, anastomoses, and regional lymph nodes. Results: Sixty-six patients were treated accordingly. Two patients went off study before or shortly after the start of chemoradiotherapy because of progressive disease. Therefore, 64 patients completed treatment as planned. During the chemoradiotherapy phase, 4 patients developed four items of Grade III dose-limiting toxicity (3 patients in Dose Level II and 1 patient in Dose Level IV). The predefined highest dose of capecitabine, 1,000 mg/m{sup 2} twice daily orally, was tolerated well and, therefore, considered safe for further clinical evaluation. Conclusions: This Phase I-II study shows that intensified chemoradiotherapy with daily capecitabine is feasible in postoperative patients with gastroesophageal junction and gastric cancer.

  12. Synthesis, spectroscopic, thermal and antimicrobial studies of neodymium(III) and samarium(III) complexes derived from tetradentate ligands containing N and S donor atoms

    NASA Astrophysics Data System (ADS)

    Ain, Qurratul; Pandey, S. K.; Pandey, O. P.; Sengupta, S. K.

    2015-04-01

    Trivalent lanthanide complexes of the type [Ln(L)Cl(H2O)2] (where Ln = Nd(III) or Sm(III) and LH2 = Schiff bases derived by the condensation of 3-(phenyl/substitutedphenyl)-4-amino-5-mercapto-1,2,4-triazole with diacetyl/benzil) have been synthesized by the reactions of anhydrous lanthanide(III) chloride with Schiff bases in methanol. The structures of the complexes have been proposed on the basis of elemental analysis, electrical conductance, magnetic moment, spectroscopic measurements (IR, 1H, 13C NMR and UV-vis spectra) and X-ray diffraction studies. The spectral data reveal that the Schiff base ligands behave as dibasic tetradentate chelating agents having coordination sites at two thiol sulfur atoms and two azomethine nitrogen atoms. The presence of coordinated water in metal complexes was confirmed by thermal and IR data of the complexes. All the Schiff bases and their metal complexes have also been screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus and antifungal activities against Aspergillus niger, Curvularia pallescens and Colletotrichum capsici.

  13. Synthesis, spectroscopic, thermal and antimicrobial studies of neodymium(III) and samarium(III) complexes derived from tetradentate ligands containing N and S donor atoms.

    PubMed

    Ain, Qurratul; Pandey, S K; Pandey, O P; Sengupta, S K

    2015-04-05

    Trivalent lanthanide complexes of the type [Ln(L)Cl(H2O)2] (where Ln=Nd(III) or Sm(III) and LH2=Schiff bases derived by the condensation of 3-(phenyl/substitutedphenyl)-4-amino-5-mercapto-1,2,4-triazole with diacetyl/benzil) have been synthesized by the reactions of anhydrous lanthanide(III) chloride with Schiff bases in methanol. The structures of the complexes have been proposed on the basis of elemental analysis, electrical conductance, magnetic moment, spectroscopic measurements (IR, 1H, 13C NMR and UV-vis spectra) and X-ray diffraction studies. The spectral data reveal that the Schiff base ligands behave as dibasic tetradentate chelating agents having coordination sites at two thiol sulfur atoms and two azomethine nitrogen atoms. The presence of coordinated water in metal complexes was confirmed by thermal and IR data of the complexes. All the Schiff bases and their metal complexes have also been screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus and antifungal activities against Aspergillus niger, Curvularia pallescens and Colletotrichum capsici.

  14. Measurements and Modeling To Determine the Reduction Potential of Uncomplexed Bi(III) in Nitrate Solutions for Application in Bi(III)-Ligand Equilibria Studies by Voltammetry.

    PubMed

    Billing, Caren; Cukrowski, Ignacy

    2016-05-12

    The free metal ion potential, E(M), is a critical parameter in the calculation of formation constants when using voltammetry. When studying complex formation of Bi(III), however, E(Bi) cannot be directly measured. In this work a nitrate background electrolyte was employed to obtain reversible reduction waves. To determine E(Bi), measurements have to be made below pH ∼ 2 before the bismuth-oxy-nitrate species precipitates and thus corrections for the diffusion junction potential (monitored using Tl(I) as an internal reference ion) must be made. Additionally shifts in potential due to both Bi(III) hydrolysis and Bi(III) nitrate formation must also be compensated for before E(Bi) can be evaluated. The value of E(Bi) was determined relative to E(Tl) so that in an experiments where ligand is added to determine formation constants, E(Bi) can be determined as accurately as possible (since E(Tl) can generally still be measured). The value of E(Bi) - E(Tl) was found to be 495.6 ± 1.4 mV for the conditions employed.

  15. Study Behavior in the Closed-Book and the Open-Book Examination: A Comparative Analysis.

    ERIC Educational Resources Information Center

    Theophilides, Christos; Koutselini, Mary

    2000-01-01

    Investigated the study behavior used by students facing an open-book or closed-book examination. Results for 201 college students in Cyprus indicate that students preparing for a closed-book examination tended to postpone study at the end of the semester, focus on assigned texts, and memorize information. Students preparing for open-book tests…

  16. Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study

    PubMed Central

    Heshmat, Ramin; Shafiee, Gita; Qorbani, Mostafa; Azizi-Soleiman, Fatemeh; Djalalinia, Shirin; Esmaeil Motlagh, Mohammad; Ardalan, Gelayol; Ahadi, Zeinab; Safari, Omid; Safiri, Saeid; Kelishadi, Roya

    2016-01-01

    Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria modified for children and adolescents. Anthropometric measures (including body mass index [BMI], waist circumference [WC] and waist to height ratio [WHtR]), blood pressure (BP) and biochemical data (including fasting blood sugar [FBS], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC] and gerlin) were measured. Results: Total ghrelin level was significantly higher in students without MetS compared to those with MetS (748.89 ± 85.04 vs. 728.72 ± 90.36 [pg/mL]; P < 0.001). Significant negative correlations were seen between ghrelin levels and BMI, WC, WHtR, TG, and TC. Ghrelin had also relatively strong inverse correlations with FBS (r = −0.59, P< 0.001), LDL-C (r = −0.56, P < 0.001), and positive correlation with HDL-C (r = 0.60, P < 0.001). Compared with the children with MetS, in those without MetS, ghrelin was significantly associated with HDL-C and LDL-C. A decreasing trend was observed in the mean ghrelin level across increasing number of MetS components (P for trend <0.001). Conclusion: We observed a relationship between ghrelin concentration and MetS components in adolescents. PMID:27777695

  17. Biochemical and genetic studies in cystinuria: observations on double heterozygotes of genotype I/II

    PubMed Central

    Morin, Claude L.; Thompson, Margaret W.; Jackson, Sanford H.; Sass-Kortsak, Andrew

    1971-01-01

    10 families with cystinuria were investigated by measuring: (a) quantitative 24 hr urinary excretion of amino acids by column chromatography; (b) endogenous renal clearances of amino acids and creatinine; (c) intestinal uptake of 34C-labeled L-cystine, L-lysine, and L-arginine using jejunal mucosal biopsies; (d) oral cystine loading tests. All four of these were studied in the probands and the first two in a large number of the family members. 49 members of 8 families were found to have a regular genetic pattern as described previously by Harris, Rosenberg, and their coworkers. Clinical or biochemical differences between the homozygotes type I (recessive cystinuria) and homozygotes type II (incompletely recessive cystinuria) have not been found. Both types excreted similarly excessive amounts of cystine, lysine, arginine, and ornithine, and had high endogenous renal clearances for these four amino acids. Some homozygotes of both types had a cystine clearance higher than the glomerular filtration rate. Jejunal mucosa from both types of homozygotes exhibited near complete inability to concentrate cystine and lysine in vitro. This was also documented in vivo with oral cystine loads. The heterozygotes type I were phenotypically normal with respect to the above four measurements. The heterozygotes type II showed moderate but definite abnormalities in their urinary excretion and their renal clearances of dibasic amino acids. Of the four amino acids concerned, cystine was the most reliable marker to differentiate between the heterozygotes type II and the homozygous normals. In this study, type III cystinuria, as described by Rosenberg, was not encountered. In two additional families, double heterozygotes of genotype I/II were found. The disease affecting these is clinically and biochemically less severe than that affecting homozygotes of either type I or type II. With respect to the four parameters used in this study, the double heterozygotes type I/II have results which

  18. Photometric study of the young open cluster NGC 3293

    NASA Astrophysics Data System (ADS)

    Baume, G.; Vázquez, R. A.; Carraro, G.; Feinstein, A.

    2003-05-01

    Deep and extensive CCD photometric observations at UBV(RI)_CHalpha were carried out in the area of the open cluster NGC 3293. The new data set allows to see the entire cluster sequence down to MV ~ +4.5, revealing that stars with MV < -2 are evolving off the main sequence; stars with -2 < MV < +2 are located on the main sequence and stars with MV > +2 are placed above it. According to our analysis, the cluster distance is d = 2750 +/- 250 pc (V0-MV = 12.2 +/- 0.2) and its nuclear age is 8 +/- 1 Myr. NGC 3293 contains an important fraction of pre-main sequence (PMS) stars distributed along a parallel band to the ZAMS with masses from 1 to 2.5 cal Msun and a mean contraction age of 10 Myr. This last value does not differ too much from the nuclear age estimate. If we take into account the many factors that may affect the PMS star positions on the colour-magnitude diagram, both ages can be perfectly reconciled. The star formation rate, on the other hand, suggests that NGC 3293 stars formed surely in one single event, therefore favouring a coeval process of star formation. Using the Halpha data, we detected nineteen stars with signs of Halpha emission in the region of NGC 3293, another indication that the star formation process is still active in the region. The computed initial mass function for the cluster has a slope of x = 1.2 +/- 0.2, a bit flatter than the typical slope for field stars and similar to the values found for other young open clusters. Based on observations collected at UTSO, ESO (Dutch 0.9 m telescope) and CASLEO. The CCD and data acquisition system at CASLEO has been partly financed by R.M. Rich through U.S. NSF Grant AST-90-15827. Full Table 1 is only available in electronic form at the CDS via an anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/402/549

  19. Theoretical studies on the photophysical properties of some Iridium (III) complexes used for OLED

    NASA Astrophysics Data System (ADS)

    Urinda, Sharmistha; Das, Goutam; Pramanik, Anup; Sarkar, Pranab

    2016-09-01

    The structural and photophysical properties of four heteroleptic Iridium (III) complexes, based on 1-phenylpyrazole ligand, have been investigated theoretically. The effect of chemical substitution on the absorption and the emission spectra of the complexes has been studied and compared with the experimental data. We observe a significant structural change in the lowest triplet excited state as compared to the ground singlet state. We compute the emission wavelength of the complexes by considering the spin-orbit coupling. Using these understandings, we predict two new complexes having deeper blue emission which are supposed to be better efficient OLED materials.

  20. NMR study on iridium(III) complexes for identifying disulfonate substituted bathophenanthroline regio-isomers.

    PubMed

    Liu, Chenchen; Yu, Linpo; Liu, Yang; Li, Fang; Zhou, Ming

    2011-12-01

    A series of novel biscyclometalated iridium (III) complexes with an ancillary disulfonated bathophenanthroline (DSBP(2-)) ligand, Ir(L)(2)DSBPNa, L = 2-phenylpyridine (ppy), 2,4-difluorophenylpyridine (fppy), and 1-phenylisoquinoline (piq) were found to have two isomeric forms. The chemical structures of the isomers were determined by the one- and two-dimensional (1)H and (13)C NMR studies. The isomeric state was proved to have originated from the disulfonate-related regio-isomer of the DSBP(2-) ligand.

  1. Vibrational properties of III-V semiconductor in wurtzite phase: A comparative density functional theory study

    NASA Astrophysics Data System (ADS)

    Gajaria, Trupti K.; Dabhi, Shweta D.; Baraiya, Bhumi A.; Mankad, Venu; Jha, Prafulla K.

    2017-05-01

    A First principles study of structural, vibrational and thermal properties of III-V semiconductor compounds viz. Indium Arsenide (InAs) and Gallium Arsenide (GaAs) are investigated in their wurtzite phase which is normally observed in the case of nanosystems. Phonon dispersion curve, Debye temperature and specific heat behavior for both the compounds are compared and discussed. The present work will have its implication for making devices with tunable properties using InAs and GaAs based heterojuction solar cells.

  2. Studies of temperature balance after open-heart surgery.

    PubMed

    Wedley, J R; Lunn, H F; Vale, R J

    1975-01-01

    An analysis of postoperative records over a two-year period has shown that a mean rise in central body temperature greater than 2 degrees occurs in patients within 12 hours of return from the operating room following open-heart surgery. In some patients the central body temperature may rise to greater than 41 degrees C. despite an adequately warm peripheral temperature, and this is associated with a high mortality rate. An apparatus has been developed which enables the immediate enviroment of the patient to be controlled. A comparison of two groups of patients, in one of which the apparatus was used, demonstrated that it was possible to attenuate significantly the usual postoperative temperature rise seen in the control group. In a third group further cooling was employed: these patients were successfully held at subnormal temperatures. Using multiple temperature probes and heat balance formulas, it was shown that the rise in central body heat was due mainly to elevation of total body heat rather than the result of redistribution of heat from the surface.

  3. A study of explosively formed fuse (EFF) opening switch resistance

    SciTech Connect

    Oona, Henn; Goforth, James H; Herrera, Dennis H; Tasker, Douglas G; Torres, D. T.

    2010-12-21

    Many pulsed power experiments need pulse shaping to optimize the power flow from a flux compression generator (FCG) to an experimental load. In a laboratory environment this can be a simple task where the switches are not destroyed. However, in experiments with high explosives, where a large amount of damage occurs, a single use EFF opening switch may be a good choice. In an EFF, explosives are used to thin a current carrying sheet of aluminum as it is forced into a grooved dye. The current is modified by the time dependent changes in resistance as the aluminum is stretched. We will correlate the hydrodynamic effects with resistance. The hydrodynamic profile is determined by Mesa-2D, a well proven hydrodynamics computer code, and MA THEMA TICA is used convert material contours into total resistance using the resistivity as a function of time from various sources. Experimentally, we will determine the actual resistance and compare it with the calculated values. We have used these switches for decades but still do not understand the details of the physics. The resistance change may be due to several processes but in this paper we will concentrate on stretching as the most important contribution. Also, in this paper we will compare the details of the hydrodynamics with the details of experimental and calculated resistance and hopefully generate a predictive model for future designs with other geometries and materials.

  4. A Dynamical Evolution Study of 40 2MASS Open Clusters

    NASA Astrophysics Data System (ADS)

    Güneş, Orhan; Karataş, Yüksel; Bonatto, Charles

    2017-05-01

    We investigate the dynamical evolution of 40 open clusters (OCs) by means of their astrophysical parameters derived from field-decontaminated 2MASS photometry. We find a bifurcation in the planes core radius vs. age and cluster radius vs. age, in which part of the clusters appear to expand with time probably due to the presence of stellar black holes while others seem to shrink due to dynamical relaxation. Mass functions (MFs) are built for 3/4 of the sample (31 OCs), which are used to search for indications of mass segregation and external dynamical processes by means of relations among astrophysical, structural and evolutionary parameters. We detect a flattening of MF slopes ocurring at the evolutionary parameters τ_{core}≤ 32 and τ_{overall}≤ 30, respectively. Within the uncertainties involved, the overall MF slopes of 14 out of 31 OCs with m_{overall} > 500 M_{⊙} are consistent with Kroupa's initial mass function, implying little or no dynamical evolution for these clusters. The remaining 17 OCs with MF slopes departing from that of Kroupa show mild/large scale mass segregation due to dynamical evolution.

  5. Meshless treatment of open inguinal hernia repair: a prospective study

    PubMed Central

    Kassab, Paulo; Franciulli, Ettore Ferrari; Wroclawski, Carolina Kassab; Ilias, Elias Jirjoss; Castro, Osvaldo Antônio Prado; Malheiros, Carlos Alberto

    2013-01-01

    ABSTRACT Objective: To evaluate two types of meshless open inguinal repair and to evaluate the recurrence rate. Methods: We operated on sequentially 98 men and 15 women with 144 unilateral or bilateral inguinal hernias between December 1988 and April 2007. The surgeries were performed by two experienced surgeons and divided into two groups: Bassini or McVay reconstructive surgery techniques. Bassini type reinforcements were employed for Nyhus II and IIIB with minor destruction of the posterior wall. Patients with Nyhus type IIIA, type IIIB with major destruction of the fascia transversalis, and type IIIC were subjected to the McVay technique. Results: Seventy-five hernias were corrected using the McVay technique. Only two recurrences (2.67%) were observed in this group. For group Bassini, two recurrences for 69 hernias (2.89%) were observed (p=0.658). Mean age for the recurrent group was 56 years. No differences were observed between the ages of males and females (52 years). Conclusions: Non-mesh repair in inguinal hernia can be safely used if performed by experienced surgeons. PMID:23843059

  6. Accurate density-functional calculation of core-electron binding energies with a scaled polarized triple-zeta basis set. (III). Extension to open-shell molecules

    NASA Astrophysics Data System (ADS)

    Hu, Ching-Han; Chong, Delano P.

    1997-03-01

    Density functional theory and the unrestricted generalized transition state (uGTS) model were applied to study the core-electron binding energies (CEBEs) of open-shell molecules. Basis set scaling based on Clementi and Raimondi's rules for atomic screening was used along with the cc-pVTZ basis set. The scaled pVTZ basis set is almost as good as the cc-pV5Z and complete basis set limit in predicting CEBEs. For small molecules (O 2, NO, NF 2 and NO 2) the average absolute deviation (aad) of our prediction (scaled pVTZ) is only 0.29 eV. For the larger molecule (CF 3) 2NO the aad is 0.56 eV, compared with experimental uncertainty of 0.5 eV. Theoretical predicted multiplet splittings for the small molecules agree quite well with experiment: the average deviation is -0.33 eV. For (CF 3) 2NO the calculated multiplet splittings are much smaller than the experimental ones. We also predict the CEBEs of PO, SN and SO, which have not been observed experimentally.

  7. Annealing properties of open volumes in strained SiN films studied by monoenergetic positron beams

    SciTech Connect

    Uedono, A.; Ito, K.; Narumi, T.; Sometani, M.; Yamabe, K.; Miyagawa, Y.; Murata, T.; Honda, K.; Hattori, N.; Matsuura, M.; Asai, K.; Ohdaira, T.; Suzuki, R.

    2007-09-15

    The effect of annealing on open volumes in strained SiN films deposited on Si by plasma enhanced chemical vapor deposition was studied using monoenergetic positron beams. For compressive SiN, the stress was reduced by postdeposition annealing; this effect was attributed to the relaxation of matrix structures accompanied by an expansion of small open spaces intrinsically existing in the matrix and the introduction of large open volumes. For tensile SiN, although annealing tends to decrease the concentration of large open volumes, the size of the small open spaces and the film stress were almost constant up to 1000 deg. C annealing. This was attributed to the network structure related to the open spaces remaining stable even at 1000 deg. C annealing, and this mainly determines the stress in the tensile film.

  8. A novel near monochromatic red emissive europium(III) metal-organic framework based on 1,2,4,5-benzenetetracarboxylate: From synthesis to photoluminescence studies

    NASA Astrophysics Data System (ADS)

    Lahoud, Marcelo G.; Frem, Regina C. G.; Marques, Lippy F.; Arroyos, Guilherme; Brandão, Paula; Ferreira, Rute A. S.; Carlos, Luís D.

    2017-09-01

    This work presents the synthesis, solid state characterization (infrared spectroscopy, thermal analysis (TGA/DTA), powder and single crystal X-ray diffraction) and photoluminescence studies of a new europium metal-organic framework (MOF), [Eu2(Btec)1,5(H2O)]n (Btec4-=1,2,4,5-benzenetetracarboxylate anion). Single crystal X-ray diffraction analysis reveals that the material has a three-dimensional network, with two crystallographically independent Eu(III) ions adopting different coordination geometries. This structure presents one of the Btec4- anions acting as a μ8-bridging linker, with the carboxylate groups in distinct connection to Eu(III) ions, culminating into an unknown coordination mode for the linker. The results of thermogravimetric analyses indicate that the MOF has high thermal stability, with this characteristic being of great interest for the application of these compounds in several fields such as catalysis and photonics. The luminescent properties showed that the Eu(III) ions are a local-spectroscopic probe, with the compound presenting a red emission when excited in the UV spectral region with absolute emission quantum yield values of 0.48 ± 0.05. The thermal dependence on the intensity of the transitions originating from the 7F1 level, especially the 7F1 → 5D1 transition, was studied. These results opens the possibility to test this MOF [Eu2(Btec)1.5(H2O)]n in the field of molecular thermometry.

  9. Forty-five years of open plan office experience: An unusual case study

    NASA Astrophysics Data System (ADS)

    Paoletti, Dennis A.

    2005-09-01

    The open plan office design concept has been around for at least 45 years. Through research, design, and practical experience, the basic concepts and parameters that impact acoustics and speech privacy have been fairly well developed and documented. The psychological aspects of human response and expectation to open plan environments, and the conceptual designs that emerge from the architect and interior designers are frontiers that still allow for ongoing study. A large open plan project completed during the dot-com bubble allowed an opportunity to design and experience an unusual open plan environment that utilized exposed sound masking system loudspeakers and minimal sound absorption.

  10. Open-label 24-week extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis.

    PubMed

    2017-10-01

    We aimed to explore the longer-term efficacy and safety of edaravone in an active-treatment extension period following the double-blind period of the second phase III study. Patients who met all the following criteria (scores ≥2 points on all 12 items of the revised amyotrophic lateral sclerosis functional rating scale [ALSFRS-R], forced vital capacity ≥80%, definite or probable ALS, and disease duration ≤2 years) were randomised to 60 mg intravenous edaravone or placebo for six cycles in the double-blind period, and then offered the opportunity to proceed to this 24-week open-label extension period. One hundred and twenty-three of 137 patients continued to the extension period: 65 edaravone-edaravone (E-E group) and 58 placebo-edaravone (P-E group). Change (mean ± standard deviation; SD) in the ALSFRS-R score from baseline in the double-blind period was -4.1 ± 3.4 and -6.9 ± 5.1 in the E-E group and P-E group, respectively, while it was -8.0 ± 5.6 in the E-E group and -10.9 ± 6.9 in the P-E group over the whole 48-week period. The ALSFRS-R score changed almost linearly throughout Cycles 1-12 in the E-E group. The most commonly reported adverse events were constipation, dysphagia, and contusion. There was no sudden deterioration in the ALSFRS-R score of the E-E group. No safety concerns related to edaravone were detected.

  11. Spectroscopic and Photometric Study of Open Cluster Trumpler 27

    NASA Astrophysics Data System (ADS)

    Obonyo, W. O.; Baki, P.

    2016-12-01

    Open clusters are essential laboratories for understanding stellar evolution, as they allow constraints to be placed on stellar ages and luminosities. As distance indicators, they are important tracers of star formation in the Milky Way. One such cluster is Trumpler 27. Spectroscopic and photometric data of Trumpler 27 was used to estimate its distance, radial velocity, age, membership and reddening. The Spectroscopic data collected from SAAO's 1.9m telescope and photometric ones from catalogues were used to estimate reddening, identify cluster stars and approximate cluster distance. Classification of spectra was done by comparing them to spectral templates. The result from this work suggests that Trumpler 27 is made up of ∼55 stars which are at different stages of evolution. The stars include main sequence stars, blue supergiants, two cool supergiants and maybe the two WR stars. The cluster's age and distance were found to be 10Myrs old and 2.6 ± 0.2 kpc away from the Sun respectively suggesting that it is located on the outer part of Scutum Centaurus arm of the Galaxy. Its reddening, E(B - V) varies substantially across the field with the average value being 1.3±0.2. It has a radial velocity of -15.3±3km/s, as approximated from some of its cool supergiants. There is a likelihood of a younger population of OB stars located at 3.5 kpc away from the sun, that is right behind Trumpler 27 interpreted as either a cluster or background stars that mimic a cluster.

  12. New Round of Studies Begin in Phase 0/I/II Cancer Prevention Clinical Trials Program | Division of Cancer Prevention

    Cancer.gov

    The NCI Division of Cancer Prevention’s Phase 0/I/II Cancer Prevention Clinical Trials Program, also known as the Consortia for Early Phase Prevention Trials, is beginning a new round of studies in the effort toward systematic early clinical development of promising preventive agents for people at increased risk of developing cancer. Infographic Highlight New Round of Studies Begin in Phase 0/I/II Cancer Prevention Clinical Trials Program |

  13. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.

    PubMed

    van Capelleveen, Julian C; Bernelot Moens, Sophie J; Yang, Xiaohong; Kastelein, John J P; Wareham, Nicholas J; Zwinderman, Aeilko H; Stroes, Erik S G; Witztum, Joseph L; Hovingh, G Kees; Khaw, Kay-Tee; Boekholdt, S Matthijs; Tsimikas, Sotirios

    2017-06-01

    Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride metabolism. Elevated triglyceride-rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The mechanism(s) through which apoC-III increases CAD risk remains largely unknown. The aim was to confirm the association between apoC-III plasma levels and CAD risk and to explore which lipoprotein subfractions contribute to this relationship between apoC-III and CAD risk. Plasma apoC-III levels were measured in baseline samples from a nested case-control study in the European Prospective Investigation of Cancer (EPIC)-Norfolk study. The study comprised 2711 apparently healthy study participants, of whom 832 subsequently developed CAD. We studied the association of baseline apoC-III levels with incident CAD risk, lipoprotein subfractions measured by nuclear magnetic resonance spectroscopy and inflammatory biomarkers. ApoC-III levels were significantly associated with CAD risk (odds ratio, 1.91; 95% confidence interval, 1.48-2.48 for highest compared with lowest quintile), retaining significance after adjustment for traditional CAD risk factors (odds ratio, 1.47; 95% confidence interval, 1.11-1.94). ApoC-III levels were positively correlated with triglyceride levels, (r=0.39), particle numbers of very-low-density lipoprotein (r=0.25), intermediate-density lipoprotein (r=0.23), small dense low-density lipoprotein (r=0.26), and high-sensitivity C-reactive protein (r=0.15), whereas an inverse correlation was observed with large low-density lipoprotein particle number (r=-0.11), P<0.001 for each. Mediation analysis indicated that the association between apoC-III and CAD risk could be explained by triglyceride elevation (triglyceride, very-low-density lipoprotein, and intermediate-density lipoprotein particles), small low-density lipoprotein particle size, and high-sensitivity C-reactive protein. ApoC-III levels are significantly associated with incident CAD risk. Elevated

  14. Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes.

    PubMed

    Dömötör, Orsolya; de Almeida, Rodrigo F M; Côrte-Real, Leonor; Matos, Cristina P; Marques, Fernanda; Matos, António; Real, Carla; Kiss, Tamás; Enyedy, Éva Anna; Helena Garcia, M; Tomaz, Ana Isabel

    2017-03-01

    Two recently published Ru(III) complexes bearing (N2O2) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh3)Cl] (salan is the tetradentate ligand 6,6'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(3-methoxyphenol) in complex 1, or 2,2'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(4-methoxyphenol) in complex 2; PPh3 is triphenylphosphane) and found very active against ovarian and breast adenocarcinoma human cells were studied to outline their antitumor mode of action. The human cisplatin-sensitive ovarian adenocarcinoma line A2780 was used herein as the cell model. At a 24h challenge (similarly as found before for 72h) both complexes are active, their cytotoxicity being comparable to that of cisplatin in the same conditions. As a possible target in the cell for their action, the interaction of 1 and 2 with DNA was assessed through displacement of well-established DNA fluorescent probes (ethidium bromide, EB, and 4',6-diamidino-2-phenylindole, DAPI) through steady-state and time-resolved fluorescence spectroscopy. The whole emission spectra were analyzed globally for the binary DNA-probe and ternary DNA-probe-Ru(III) complex systems. Both Ru(III) complexes can displace EB and bind to DNA with similar and moderate strong affinity with conditional stability constants of logK'=(5.05±0.01) for 1 and logK'=(4.79±0.01) for 2. The analysis of time-domain fluorescence intensity decays confirmed both qualitatively and quantitatively the model used to describe the binding and competition processes. Cell studies indicated that apoptosis is the major mechanism of cell death for both complexes, with 2 (the more active complex) promoting that process more efficiently than 1. Transmission electron micrographs revealed clear alterations on intracellular organization consistent with the induction of programmed cell death processes.

  15. High-spin chloro mononuclear MnIII complexes: a multifrequency high-field EPR study.

    PubMed

    Mantel, Claire; Chen, Hongyu; Crabtree, Robert H; Brudvig, Gary W; Pécaut, Jacques; Collomb, Marie-Noëlle; Duboc, Carole

    2005-03-01

    The isolation, structural characterization, and electronic properties of two six-coordinated chloromanganese (III) complexes, [Mn(terpy)(Cl)3] (1) and [Mn(Phterpy)(Cl)3] (2), are reported (terpy = 2,2':6'2"-terpyridine, Phterpy = 4'-phenyl-2,2':6',2"-terpyridine). These complexes complement a series of mononuclear azide and fluoride Mn(lll) complexes synthesized with neutral N-tridentate ligands, [Mn(L)(X)3] (X = F- or N3 and L = terpy or bpea [N,N-bis(2-pyridylmethyl)-ethylamine)], previously described. Similar to these previous complexes, 1 and 2 exhibit a Jahn-Teller distortion of the octahedron, characteristic of a high-spin Mn(III) complex (S = 2). The analysis of the crystallographic data shows that, in both cases, the manganese ion lies in the center of a distorted octahedron characterized by an elongation along the tetragonal axis. Their electronic properties were investigated by multifrequency EPR (190-475 GHz) performed in the solid state at different temperatures (5-15 K). This study confirms our previous results and further shows that: i) the sign of D is correlated with the nature of the tetragonal distortion; ii) the magnitude of D is not sensitive to the nature of the anions in our series of rhombic complexes, contrary to the porphyrinic systems; iii) the [E/D] values (0.124 for 1 and 0.085 for 2) are smaller compared to those found for the [Mn(L)(X)3] complexes (in the range of 0.146 to 0.234); and iv) the E term increases when the ligand-field strength of the equatorial ligands decreases.

  16. Performance of Dutch children on the Bayley III: a comparison study of US and Dutch norms.

    PubMed

    Steenis, Leonie J P; Verhoeven, Marjolein; Hessen, Dave J; van Baar, Anneloes L

    2015-01-01

    The Bayley Scales of Infant and Toddler Development-third edition (Bayley-III) are frequently used to assess early child development worldwide. However, the original standardization only included US children, and it is still unclear whether or not these norms are adequate for use in other populations. Recently, norms for the Dutch version of the Bayley-III (The Bayley-III-NL) were made. Scores based on Dutch and US norms were compared to study the need for population-specific norms. Scaled scores based on Dutch and US norms were compared for 1912 children between 14 days and 42 months 14 days. Next, the proportions of children scoring < 1-SD and < -2 SD based on the two norms were compared, to identify over- or under-referral for developmental delay resulting from non-population-based norms. Scaled scores based on Dutch norms fluctuated around values based on US norms on all subtests. The extent of the deviations differed across ages and subtests. Differences in means were significant across all five subtests (p < .01) with small to large effect sizes (ηp2) ranging from .03 to .26). Using the US instead of Dutch norms resulted in over-referral regarding gross motor skills, and under-referral regarding cognitive, receptive communication, expressive communication, and fine motor skills. The Dutch norms differ from the US norms for all subtests and these differences are clinically relevant. Population specific norms are needed to identify children with low scores for referral and intervention, and to facilitate international comparisons of population data.

  17. The construction of open Gd(III) metal-organic frameworks based on methanetriacetic acid: new objects with an old ligand.

    PubMed

    Cañadillas-Delgado, Laura; Martín, Tomás; Fabelo, Oscar; Pasán, Jorge; Delgado, Fernando S; Lloret, Francesc; Julve, Miguel; Ruiz-Pérez, Catalina

    2010-04-06

    The preparation, X-ray crystallography and magnetic investigation of the first examples of methanetriacetate (mta)-containing lanthanide(III) complexes of formulae [Gd(mta)(H(2)O)(3)](n)4 n H(2)O (1) [Gd(mta)(H(2)O)(3)](n)2 n H(2)O (2) and [Gd(2)(mta)(2)(H(2)O)(2)](n)2 n H(2)O (3) are described herein. This tripodal ligand promotes the formation of 6(3) networks; thus 1 consists of a honeycomb structure, whereas in 2 two of these layers are condensed to form a rare five-connected two-dimensional (4(8)6(2)) network. Compound 3 can be seen as an aggregation of 6(3) layers leading to a three-dimensional (6,6)-connected binodal (4(12)6(3))(4(9)6(6))-nia net, in which the gadolinium(III) ions and the mta ligands act as octahedral and as trigonal prismatic nodes, respectively. The magnetic properties of 1-3 were investigated in the temperature range 1.9-300 K. A close fit to the Curie law (1) and weak either antiferro- [J=-0.0063(1) cm(-1) (2)] or ferromagnetic [J=+0.0264(6) cm(-1) (3)] interactions between the Gd(III) ions are observed; the different exchange pathways involved [extended tris-bidentate mta (1) and mu-O(1);kappa(2)O(1),O(2) (2 and 3) plus single syn-syn carboxylate-mta (3)] accounting for these magnetic features. The nature and magnitude of the magnetic interactions, between the Gd(III) ions in 1-3, agree with the small amount of data existing in the literature for these kind of bridges.

  18. Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes.

    PubMed

    Basha, Maram T; Bordini, Jeane; Richardson, Des R; Martinez, Manuel; Bernhardt, Paul V

    2016-09-01

    The oxidation of human oxyhemoglobin (HbO2) to methemoglobin (metHb) is an undesirable side effect identified in some promising thiosemicarbazone anti-cancer drugs. This is attributable to oxidation reactions driven by Fe(III) complexes of these drugs formed in vivo. In this work the Fe(III) complexes of selected 2-benzoylpyridine thiosemicarbazones (HBpT), 2-acetylpyridine thiosemicarbazones (HApT), and the clinically trialled thiosemicarbazone, Triapine® (3-amino-2-pyridinecarboxaldehyde thiosemicarbazone, H3-AP), have been studied. This was achieved by time-resolved UV-Visible absorption spectroscopy and the sequential oxidation of the α- and β-chains of HbO2 at distinctly different rates has been identified. A key structural element, namely a terminal -NH2 group on the thiosemicarbazone moiety, was found to be an important common feature of the most active HbO2 oxidising complexes that were investigated. Therefore, these studies indicate that an unsubstituted -NH2 moiety at the terminus of the thiosemicarbazone group should be avoided in the design of future compounds from this class. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Virtual Tutorials in Adult ODL: A WizIQ Case Study of Wawasan Open University

    ERIC Educational Resources Information Center

    Bhandigadi, Phalachandra; Abeywardena, Ishan Sudeera

    2014-01-01

    Wawasan Open University (WOU) was established in 2007 with the sole aim of providing affordable and accessible higher education opportunities to working adults in the fields of business, technology, education and liberal studies. As part of its Open Distance Learning (ODL) delivery, WOU provides tutorial support for students every semester through…

  20. Differential Use of the Open Classroom: A Study of Exploratory and Cautious Children. Final Report.

    ERIC Educational Resources Information Center

    Minuchin, Patricia

    The purpose of this study was to investigate the differences between exploratory children and cautious children as they functioned in open classrooms over a period of time and to document some general aspects of child behavior in open educational settings. Sixty children were observed through the course of the school year in their first grade open…

  1. Differential Use of the Open Classroom: A Study of More and Less Exploratory Children.

    ERIC Educational Resources Information Center

    Minuchin, Patricia P.

    This grant application describes the theoretical background and research design of a project intended to study the interaction between children's styles of functioning and the opportunities and requirements of an open classroom environment. A major assumption to be tested is that exploratory children function more effectively in open classrooms.…

  2. Interactive Radio Counseling in Indira Gandhi National Open University: A Study.

    ERIC Educational Resources Information Center

    Chaudhary, Sohanvir S.; Bansal, Kiron

    2000-01-01

    Explains interactive radio as an effective tool for open and distance learning provided it is planned, designed, implemented, and monitored systematically. Describes the interactive radio counseling at Indira Gandhi National Open University (IGNOU) that provides support to students who study print material and may attend weekend…

  3. Looking toward the Future: A Case Study of Open Source Software in the Humanities

    ERIC Educational Resources Information Center

    Quamen, Harvey

    2006-01-01

    In this article Harvey Quamen examines how the philosophy of open source software might be of particular benefit to humanities scholars in the near future--particularly for academic journals with limited financial resources. To this end he provides a case study in which he describes his use of open source technology (MySQL database software and…

  4. Planning and Developing Open and Distance Learning : A Quality Assurance Approach. Radiological Studies in Distance Education.

    ERIC Educational Resources Information Center

    Melton, Reginald F.

    This book presents a blueprint for using a quality assurance-based approach to planning and developing open and distance learning (ODL) courses in the United Kingdom. The following are among the specific topics discussed: (1) typical aims of ODL (opening access to education; responding to student needs; designing self-study materials; student…

  5. Interactive Radio Counseling in Indira Gandhi National Open University: A Study.

    ERIC Educational Resources Information Center

    Chaudhary, Sohanvir S.; Bansal, Kiron

    2000-01-01

    Explains interactive radio as an effective tool for open and distance learning provided it is planned, designed, implemented, and monitored systematically. Describes the interactive radio counseling at Indira Gandhi National Open University (IGNOU) that provides support to students who study print material and may attend weekend…

  6. Planning and Developing Open and Distance Learning : A Quality Assurance Approach. Radiological Studies in Distance Education.

    ERIC Educational Resources Information Center

    Melton, Reginald F.

    This book presents a blueprint for using a quality assurance-based approach to planning and developing open and distance learning (ODL) courses in the United Kingdom. The following are among the specific topics discussed: (1) typical aims of ODL (opening access to education; responding to student needs; designing self-study materials; student…

  7. Exploring Open Distance Learning at a Jordanian University: A Case Study

    ERIC Educational Resources Information Center

    Dirani, Khalil M.; Yoon, Seung Won

    2009-01-01

    This case study explores an open distance learning program offered by the Information Technology and Computing (ITC) department at AOUJ, a major university in Jordan. It provides an overview of e-learning in the Arab region and explores factors that affect ODL quality in the Arab Open University in Jordan (AOUJ). The research utilized a…

  8. Looking toward the Future: A Case Study of Open Source Software in the Humanities

    ERIC Educational Resources Information Center

    Quamen, Harvey

    2006-01-01

    In this article Harvey Quamen examines how the philosophy of open source software might be of particular benefit to humanities scholars in the near future--particularly for academic journals with limited financial resources. To this end he provides a case study in which he describes his use of open source technology (MySQL database software and…

  9. A fluorescence spectroscopic study on the speciation of Cm(III) and Eu(III) in the presence of organic chelates in highly basic solutions

    SciTech Connect

    Wang, Zheming; Felmy, Andrew R.; Xia, Yuanxian; Mason, Marvin J.

    2003-07-15

    The speciation of Eu(III) and Cm(III) was investigated by time resolved laser fluorescence spectroscopy (TRLFS) over a range of base concentrations ranging from 0.01m NaOH to 7.5M NaOH and in the presence of several organic chelates including EDTA, HEDTA, NTA, and oxalate. The results of this work suggest that both Eu(III) and Cm(III) form strong mixed ligand complexes with organic chelates and the hydroxyl groups(s) in dilute NaOH solutions. However, in concentrated NaOH solutions, Eu(III)-/Cm(III)-containing colloidal nanoparticles are the primary cause for the measured Eu(III)/Cm(III) in the aqueous solutions. Therefore, the interpretation of these data solely in terms of the formation of amphoteric hydroxyl species (e.g. Eu(OH)4-) would appear to be inappropriate. The organic chelating ligands form strong complexes with surface Cm(III)/Eu(III) sites of the colloidal nanoparticles. For Cm(III), such surface complexes show largely red-shifted fluorescence spectra as compared with the aqueous complexes and unusually short fluorescence lifetimes. The decreased fluorescence lifetimes are likely due to the presence of transition metal ions, such as Fe3+, in the nanoparticle as well as reduced inter-nuclear distance between neighboring Cm(III) centers.

  10. Highly efficient detoxification of Cr(VI) by chitosan-Fe(III) complex: process and mechanism studies.

    PubMed

    Shen, Chensi; Chen, Hui; Wu, Shaoshuai; Wen, Yuezhong; Li, Lina; Jiang, Zheng; Li, Meichao; Liu, Weiping

    2013-01-15

    Metal-biopolymer complexes has recently gained significant attention as an effective adsorbent used for the removal of Cr(VI) from water. Unfortunately, despite increasing research efforts in the field of removal efficiency, whether this kind of complex can reduce Cr(VI) to less-toxic Cr(III) and what are the mechanisms of detoxification processes are still unknown. In this study, despite the highly adsorption efficiency (maximum adsorption capacity of 173.1 mg/g in 10 min), the significant improvement of Cr(VI) reduction by chitosan-Fe(III) complex compared with normal crosslinked chitoan has been demonstrated. In addition, the structure of chitosan-Fe(III) complex and its functional groups concerned with Cr(VI) detoxification have been characterized by the powerful spectroscopic techniques X-ray absorption fine structure (XAFS) and X-ray photoelectron spectroscopy (XPS). The XPS spectra indicated that the primary alcoholic function on C-6 served as an electron donor during Cr(VI) reduction and was oxidized to a carbonyl group. The X-ray adsorption near edge spectra (XANES) of the Cr(VI)-treated chitosan-Fe(III) complex revealed the similar geometrical arrangement of Cr species as that in Cr(III)-bound chitosan-Fe(III). Overall, a possible process and mechanism for highly efficient detoxification of Cr(VI) by chitosan-Fe(III) complex has been elucidate. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. XAS study of iron and arsenic speciation during Fe(II) oxidation in the presence of As(III).

    PubMed

    Thoral, S; Rose, J; Garnier, J M; Van Geen, A; Refait, M P; Traverse, A; Fonda, E; Nahon, D; Bottero, J Y

    2005-12-15

    The speciation of As and Fe was studied during the oxidation of Fe(II)-As(III) solutions by combining XAS analysis at both the Fe and As K-edges. Fe(II) and As(III) were first hydrolyzed to pH 7 under anoxic conditions; the precipitate was then allowed to oxidize in ambient air for 33 h under vigorous stirring. EXAFS analysis at the As K-edge shows clear evidence of formation of inner-sphere complexes between As(III) and Fe(II), i.e., before any oxidation. Inner-sphere complexes were also observed when Fe became sufficiently oxidized, in the form of edge-sharing and double-corner linkages between AsIIIO3 pyramids and FeIIIO6 octahedra. XAS analyses at the Fe K-edge reveal that the presence of As(III) in the solution limits the polymerization of Fe(II) and the formation of green rust and inhibits the formation of goethite and lepidocrocite. Indeed, As(III) accelerates the Fe(II) oxidation kinetics and leads to the formation of nanosized Fe-As subunits of amorphous aggregates. These observations, rather than a presumed weaker affinity of As(III) for iron oxyhydroxides, might explain why As(III) is more difficult to remove than As(V) by aerating reducing groundwater.

  12. Complexation of lanthanides(III), americium(III), and uranium(VI) with bitopic N,O ligands: an experimental and theoretical study.

    PubMed

    Marie, Cécile; Miguirditchian, Manuel; Guillaumont, Dominique; Tosseng, Arnaud; Berthon, Claude; Guilbaud, Philippe; Duvail, Magali; Bisson, Julia; Guillaneux, Denis; Pipelier, Muriel; Dubreuil, Didier

    2011-07-18

    New functionalized terpyridine-diamide ligands were recently developed for the group actinide separation by solvent extraction. In order to acquire a better understanding of their coordination mode in solution, protonation and complexation of lanthanides(III), americium(III), and uranium(VI) with these bitopic N,O-bearing ligands were studied in homogeneous methanol/water conditions by experimental and theoretical approaches. UV-visible spectrophotometry was used to determine the protonation and stability constants of te-tpyda and dedp-tpyda. The conformations of free and protonated forms of te-tpyda were investigated using NMR and theoretical calculations. The introduction of amide functional groups on the terpyridine moiety improved the extracting properties of these new ligands by lowering their basicity and enhancing the stability of the corresponding 1:1 complexes with lanthanides(III). Coordination of these ligands was studied by density functional theory and molecular dynamics calculations, especially to evaluate potential participation of hard oxygen and soft nitrogen atoms in actinide coordination and to correlate with their affinity and selectivity. Two predominant inner-sphere coordination modes were found from the calculations: one mode where the cation is coordinated by the nitrogen atoms of the cavity and by the amide oxygen atoms and the other mode where the cation is only coordinated by the two amide oxygen atoms and by solvent molecules. Further simulations and analysis of UV-visible spectra using both coordination modes indicate that inner-sphere coordination with direct complexation of the three nitrogen and two oxygen atoms to the cation leads to the most likely species in a methanol/water solution.

  13. Enhancing the luminescence properties and stability of cationic iridium(III) complexes based on phenylbenzoimidazole ligand: a combined experimental and theoretical study.

    PubMed

    Shan, Guo-Gang; Li, Hai-Bin; Sun, Hai-Zhu; Cao, Hong-Tao; Zhu, Dong-Xia; Su, Zhong-Min

    2013-08-21

    Herein we designed and synthesized a series of cationic iridium(III) complexes with a phenylbenzoimidazole-based cyclometalated ligand, containing different numbers of carbazole moieties from zero to three (complexes 1-4). The photophysical and electrochemical properties of this series have been systematically investigated. The complexes exhibit strong luminescence in both solution and in neat films, as well as excellent redox reversibility. Introducing carbazole groups into the complexes is found to lead to substantially enhanced photoluminescence quantum efficiency in the neat film, but has little effect on the emitting color and excited-state characteristics as supported by density functional theory (DFT) results. DFT calculations also suggest that functionalized complexes 2-4 reveal better hole-transporting properties than 1. More importantly, all complexes effectively reduce the degradation reaction to some extent in metal-centered (³MC) excited-states, demonstrating their stability. Further studies indicate that restriction of opening of the structures in the ³MC state is caused by the unique molecular conformation of the phenylbenzoimidazole ligand, which is first demonstrated here in cationic iridium(III) complexes without intramolecular π-π stacking. These results presented here would provide valuable information for designing and synthesizing highly efficient and stable cationic iridium(III) complexes suitable for the optical devices.

  14. Rotigotine transdermal system for long-term treatment of patients with advanced Parkinson's disease: results of two open-label extension studies, CLEOPATRA-PD and PREFER.

    PubMed

    LeWitt, Peter A; Boroojerdi, Babak; Surmann, Erwin; Poewe, Werner

    2013-07-01

    Open-label extensions [studies SP516 (NCT00501969) and SP715 (NCT00594386)] of the CLEOPATRA-PD and PREFER studies were conducted to evaluate the safety, tolerability and efficacy of the dopaminergic agonist, rotigotine, over several years of follow-up in patients with advanced Parkinson's disease (PD). Eligible subjects completing the double-blind trials received open-label adjunctive rotigotine (≤16 mg/24 h) for up to 4 and 6 years in Studies SP516 and SP715, respectively. Safety and tolerability were assessed using adverse events, vital signs and laboratory parameters, and efficacy assessed using the unified Parkinson's disease rating scale (UPDRS). Of the 395 and 258 patients enrolled in the SP516 and SP715 studies, 48 and 45 % completed, respectively. Adverse events were typically dopaminergic effects [e.g., somnolence (18-25 %/patient-year), insomnia (5-7 %/patient-year), dyskinesias (4-8 %/patient-year) and hallucinations (4-8 %/patient-year)], or related to the transdermal application of a patch (application site reactions: 14-15 %/patient-year). There were no clinically relevant changes in vital signs or laboratory parameters in either study. Mean UPDRS part II (activities of daily living) and part III (motor function) total scores improved from double-blind baseline during dose titration, then gradually declined over the maintenance period. In study SP516, mean UPDRS part II and III total scores were 0.8 points above and 2.8 points below double-blind baseline, respectively, at end of treatment. In study SP715, mean UPDRS part II and III total scores were 4.1 points above and 0.2 points below baseline, respectively, at end of treatment. In these open-label studies, adjunctive rotigotine was efficacious with an acceptable safety and tolerability profile in patients with advanced PD for up to 6 years.

  15. A Phase III, randomized, open-label trial of ferumoxytol compared with iron sucrose for the treatment of iron deficiency anemia in patients with a history of unsatisfactory oral iron therapy.

    PubMed

    Hetzel, David; Strauss, William; Bernard, Kristine; Li, Zhu; Urboniene, Audrone; Allen, Lee F

    2014-06-01

    Iron deficiency anemia (IDA) is the most common form of anemia worldwide. Although oral iron is used as first-line treatment, many patients are unresponsive to or cannot take oral iron. This Phase III, open-label, non-inferiority study compared the efficacy and safety of ferumoxytol, a rapid, injectable intravenous (IV) iron product with low immunological reactivity and minimal detectable free iron, with IV iron sucrose in adults with IDA of any cause. Patients (N = 605) were randomized 2:1 to receive ferumoxytol (n = 406, two doses of 510 mg 5 ± 3 days apart) or iron sucrose (n = 199, five doses of 200 mg on five nonconsecutive days over 14 days) and followed for 5 weeks. Ferumoxytol demonstrated noninferiority to iron sucrose at the primary endpoint, the proportion of patients achieving a hemoglobin increase of ≥2 g dL(-1) at any time from Baseline to Week 5 (ferumoxytol, 84.0% [n = 406] vs. iron sucrose, 81.4% [n = 199]), with a noninferiority margin of 15%. Ferumoxytol was superior to iron sucrose (2.7 g dL(-1) vs. 2.4 g dL(-1) ) in the mean change in hemoglobin from Baseline to Week 5 (the alternative preplanned primary endpoint) with P = 0.0124. Transferrin saturation, quality-of-life measures, and safety outcomes were similar between the two treatment groups. Overall, ferumoxytol demonstrated comparable safety and efficacy to iron sucrose, suggesting that ferumoxytol may be a useful treatment option for patients with IDA in whom oral iron was unsatisfactory or could not be used.

  16. Synthesis, characterization and antibacterial studies of ruthenium(III) complexes derived from chitosan schiff base.

    PubMed

    Vadivel, T; Dhamodaran, M

    2016-09-01

    Chitosan can be modified chemically by condensation reaction of deacetylated chitosan with aldehyde in homogeneous phase. This condensation is carried by primary amine (NH2) with aldehyde (CHO) to form corresponding schiff base. The chitosan biopolymer schiff base derivatives are synthesized with substituted aldehydes namely 4-hydroxy-3-methoxy benzaldehyde, 2-hydroxy benzaldehyde, and 2-hydroxy-3-methoxy benzaldehyde, becomes a complexing agent or ligand. The Ruthenium(III) complexes were obtained by complexation of Ruthenium with schiff base ligands and this product exhibits as an excellent solubility and more biocompatibility. The novel series of schiff base Ruthenium(III) complexes are characterized by Elemental analysis, FT-IR spectroscopy, and Thermo-gravimetric analysis (TGA). The synthesized complexes have been subjected to antibacterial study. The antibacterial results indicated that the antibacterial activity of the complexes were more effective against Gram positive and Gram negative pathogenic bacteria. These findings are giving suitable support for developing new antibacterial agent and expand our scope for applications. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Study of Flare Energy Release Using Events with Numerous Type III-like Bursts in Microwaves

    NASA Astrophysics Data System (ADS)

    Meshalkina, N. S.; Altyntsev, A. T.; Zhdanov, D. A.; Lesovoi, S. V.; Kochanov, A. A.; Yan, Y. H.; Tan, C. M.

    2012-10-01

    The analysis of narrowband drifting of type III-like structures in radio bursts dynamic spectra allows one to obtain unique information about the primary energy release mechanisms in solar flares. The SSRT (Siberian Solar Radio Telescope) spatially resolved images and its high spectral and temporal resolution allow for direct determination not only of the source positions but also of the exciter velocities along the flare loop. Practically, such measurements are possible during some special time intervals when SSRT is observing the flare region in two high-order fringes near 5.7 GHz; thus, two 1D brightness distributions are recorded simultaneously at two frequency bands. The analysis of type III-like bursts recorded during the flare 14 April 2002 is presented. Using multiwavelength radio observations recorded by the SSRT, the Huairou Solar Broadband Radio Spectrometer (SBRS), the Nobeyama Radio Polarimeters (NoRP), and the Radio Solar Telescope Network (RSTN), we study an event with series of several tens of drifting microwave pulses with drift rates in the range from -7 to 13 GHz s-1. The sources of the fast-drifting bursts were located near the top of a flare loop in a volume of a few Mm in size. The slow drift of the exciters along the flare loop suggests a high pitch anisotropy of the emitting electrons.

  18. A study of capping layers for sulfur monolayer doping on III-V junctions

    NASA Astrophysics Data System (ADS)

    Yum, J. H.; Shin, H. S.; Hill, R.; Oh, J.; Lee, H. D.; Mushinski, Ryan M.; Hudnall, Todd W.; Bielawski, C. W.; Banerjee, S. K.; Loh, W. Y.; Wang, Wei-E.; Kirsch, Paul

    2012-12-01

    Recently, high dosage doping on Si multi-gate field effect transistors and III-V planar structures using a self-limiting monolayer doping technique was reported to overcome challenges in scaling nano-sized transistors. The stoichiometry or composition of the capping layer was found to affect the diffusion efficiency of this process. In this work, we study the effect of a capping layer in sulfur monolayer doping on III-V junctions. Various capping temperatures and growth methods were compared. Based on the theoretical and experimental results, we suggest an optimized scheme consisting of a bi-layer capping structure. From Hall measurements and secondary ion mass spectrometry, a SiNx/BeO bi-layer capping, compared to single layer cap, exhibited the best results with a surface sheet resistance of 232 Ω/sq, junction depth of 11 nm, dopant profile abruptness of 3.5 nm/dec, electrically active S concentration of 4.9 × 1019/cm3 (=1.34 × 1013/cm2), and 3 times higher activation efficiency without significant transient-enhanced dopant diffusion.

  19. Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials

    PubMed Central

    Stein, Donald G.

    2015-01-01

    Abstract Background: Despite positive preclinical studies and two positive Phase II clinical trials, two large Phase III clinical trials of progesterone treatment of acute traumatic brain injury (TBI) recently ended with negative results, so a 100% failure rate continues to plague the field of TBI trials. Methods: This paper reviews and analyses the trial structures and outcomes and discusses the implications of these failures for future drug and clinical trial development. Persistently negative trial outcomes have led to disinvestment in new drug research by companies and policy-makers and disappointment for patients and their families, failures which represent a major public health concern. The problem is not limited to TBI. Failure rates are high for trials in stroke, sepsis, cardiology, cancer and orthopaedics, among others. Results: This paper discusses some of the reasons why the Phase III trials have failed. These reasons may include faulty extrapolation from pre-clinical data in designing clinical trials and the use of subjective outcome measures that accurately reflect neither the nature of the deficits nor long-term quantitative recovery. Conclusions: Better definitions of injury and healing and better outcome measures are essential to change the embrace of failure that has dominated the field for over 30 years. This review offers suggestions to improve the situation. PMID:26274493

  20. A Statistical Study of Brown Dwarf Companions from the SDSS-III MARVELS Survey

    NASA Astrophysics Data System (ADS)

    Grieves, Nolan; Ge, Jian; Thomas, Neil; Ma, Bo; De Lee, Nathan M.; Lee, Brian L.; Fleming, Scott W.; Sithajan, Sirinrat; Varosi, Frank; Liu, Jian; Zhao, Bo; Li, Rui; Agol, Eric; MARVELS Team

    2016-01-01

    We present 23 new Brown Dwarf (BD) candidates from the Multi-object APO Radial-Velocity Exoplanet Large-Area Survey (MARVELS) of the Sloan Digital Sky Survey III (SDSS-III). The BD candidates were selected from the processed MARVELS data using the latest University of Florida 2D pipeline, which shows significant improvement and reduction of systematic errors over the 1D pipeline results included in the SDSS Data Release 12. This sample is the largest BD yield from a single radial velocity survey. Of the 23 candidates, 18 are around main sequence stars and 5 are around giant stars. Given a giant contamination rate of ~24% for the MARVELS survey, we find a BD occurrence rate around main sequence stars of ~0.7%, which agrees with previous studies and confirms the BD desert, while the BD occurrence rate around the MARVELS giant stars is ~0.6%. Preliminary results show that our new candidates around solar type stars support a two population hypothesis, where BDs are divided at a mass of ~42.5 MJup. BDs less massive than 42.5 MJup have eccentricity distributions consistent with planet-planet scattering models, where BDs more massive than 42.5 MJup have both period and eccentricity distributions similar to that of stellar binaries. Special Brown Dwarf systems such as multiple BD systems and highly eccentric BDs will also be presented.

  1. WIYN open cluster study. LIX. Radial velocity membership of the evolved population of the old open cluster NGC 6791

    SciTech Connect

    Tofflemire, Benjamin M.; Gosnell, Natalie M.; Mathieu, Robert D.; Platais, Imants E-mail: imants@pha.jhu.edu

    2014-10-01

    The open cluster NGC 6791 has been the focus of much recent study due to its intriguing combination of old age and high metallicity (∼8 Gyr, [Fe/H] = +0.30), as well as its location within the Kepler field. As part of the WIYN Open Cluster Study, we present precise (σ = 0.38 km s{sup –1}) radial velocities for proper motion candidate members of NGC 6791 from Platais et al. Our survey, extending down to g' ∼ 16.8, is comprised of the evolved cluster population, including blue stragglers, giants, and horizontal branch stars. Of the 280 proper-motion-selected stars above our magnitude limit, 93% have at least one radial velocity measurement and 79% have three measurements over the course of at least 200 days, sufficient for secure radial-velocity-determined membership of non-velocity-variable stars. The Platais et al. proper motion catalog includes 12 anomalous horizontal branch candidates blueward of the red clump, of which we find only 4 to be cluster members. Three fall slightly blueward of the red clump and the fourth is consistent with being a blue straggler. The cleaned color-magnitude diagram shows a richly populated red giant branch and a blue straggler population. Half of the blue stragglers are in binaries. From our radial velocity measurement distribution, we find the cluster's radial velocity dispersion to be σ {sub c} = 0.62 ± 0.10 km s{sup –1}. This corresponds to a dynamical mass of ∼4600 M {sub ☉}.

  2. Acetabuloplasties at Open Reduction Prevent Acetabular Dysplasia in Intentionally Delayed Developmental Dysplasia of the Hip: A Case-control Study.

    PubMed

    Carsi, M Belen; Clarke, Nicholas M P

    2016-05-01

    of patients who developed AVN (11 of 27 [41%] both groups; OR, 1; 95% CI, 1-2; p = 1). The addition of an incomplete periacetabular acetabuloplasty to all hips undergoing open reduction eliminated residual acetabular dysplasia, whereas it did not appear to have deleterious effects as evidenced by the similar AVN proportion. Level III, therapeutic study.

  3. Lanthanum(III) and Lutetium(III) in Nitrate-Based Ionic Liquids: A Theoretical Study of Their Coordination Shell.

    PubMed

    Bodo, Enrico

    2015-09-03

    By using ab initio molecular dynamics, we investigate the solvent shell structure of La(3+) and Lu(3+) ions immersed in two ionic liquids, ethylammonium nitrate (EAN) and its hydroxy derivative (2-ethanolammonium nitrate, HOEAN). We provide the first study of the coordination properties of these heavy metal ions in such a highly charged nonacqueous environment. We find, as expected, that the coordination in the liquid is mainly due to nitrate anions and that, due to the bidentate nature of the ligand, the complexation shell of the central ion has a nontrivial geometry and a coordination number in terms of nitrate molecules that apparently violates the decrease of ionic radii along the lanthanides series, since the smaller Lu(3+) ion seems to coordinate six nitrate molecules and the La(3+) ion only five. A closer inspection of the structural features obtained from our calculations shows, instead, that the first shell of oxygen atoms is more compact for Lu(3+) than for La(3+) and that the former coordinates 8 oxygen atoms while the latter 10 in accord with the typical lanthanide's trend along the series and that their first solvation shells have a slight irregular and complex geometrical pattern. When moving to the HOEAN solutions, we have found that the solvation of the central ion is possibly also due to the cation itself through the oxygen atom on the side chain. Also, in this liquid, the coordination numbers in terms of oxygen atoms in both solvents is 10 for La(3+) and 8 for Lu(3+).

  4. Synthesis, Spectroscopic, ac Conductivity and Thermal Studies on Co(III) Acetylacetonate-Iodine Complex

    NASA Astrophysics Data System (ADS)

    Hashem, H. A.; Refat, M. S.

    A spectrophotometric study of 1:1 donor-acceptor complex, cobalt (III) acetylacetonate (donor) and iodine (σ-acceptor) has been preformed. The equilibrium constants, (K) and the absorpitivity (ɛ) for the formation of the iodine complex have been calculated. The predicted structure of the solid triiodide charge-transfer complex reported in this study is further supported by thermal, far and mid infrared spectroscopic measurements. Electron transfer from Co (acac = 2, 4-pentanedionate)3 to iodine leads to the formation of an organic semiconductor with the formula of [Co(acac)3]_2 I+. I3-. The kinetic parameters (nonisothermal method) for their decomposition have been evaluated by graphical methods using the equations of Freeman-Carroll (FC), Horowitz-Metzger (HM) and Coats-Redfern (CR). The ac conductivity and dielectric properties of [Co(acac)3]_2 I+. I3- have been measured over the frequency 50-106 Hz at temperature 298 K.

  5. Bacterial flagella and Type III secretion: case studies in the evolution of complexity.

    PubMed

    Pallen, M J; Gophna, U

    2007-01-01

    Bacterial flagella at first sight appear uniquely sophisticated in structure, so much so that they have even been considered 'irreducibly complex' by the intelligent design movement. However, a more detailed analysis reveals that these remarkable pieces of molecular machinery are the product of processes that are fully compatible with Darwinian evolution. In this chapter we present evidence for such processes, based on a review of experimental studies, molecular phylogeny and microbial genomics. Several processes have played important roles in flagellar evolution: self-assembly of simple repeating subunits, gene duplication with subsequent divergence, recruitment of elements from other systems ('molecular bricolage'), and recombination. We also discuss additional tentative new assignments of homology (FliG with MgtE, FliO with YscJ). In conclusion, rather than providing evidence of intelligent design, flagellar and non-flagellar Type III secretion systems instead provide excellent case studies in the evolution of complex systems from simpler components.

  6. Dysprosium(III)-Catalyzed Ring-Opening of meso-Epoxides: Desymmetrization by Remote Stereocontrol in a Thiolysis/Elimination Sequence.

    PubMed

    Yao, Lu; Zhu, Qiao; Wei, Liang; Wang, Zuo-Fei; Wang, Chun-Jiang

    2016-05-04

    An unprecedented asymmetric desymmetrization of meso-epoxides, derived from cyclopentene-1,3-diones, with 2-mercaptobenzothiazoles has been realized. It was efficiently catalyzed by a chiral Dy(III) /N,N'-dioxide complex through a thiolysis/elimination sequence. This remote stereocontrol strategy provides facile access to synthetically versatile cyclopentene derivatives bearing an all-carbon quaternary stereogenic center in high yield and excellent enantioselectivity. Intriguingly, optically active thiophene could be readily generated from the obtained product through an efficient one-pot protocol.

  7. III-antimonide/nitride based semiconductors for optoelectronic materials and device studies : LDRD 26518 final report.

    SciTech Connect

    Kurtz, Steven Ross; Hargett, Terry W.; Serkland, Darwin Keith; Waldrip, Karen Elizabeth; Modine, Normand Arthur; Klem, John Frederick; Jones, Eric Daniel; Cich, Michael Joseph; Allerman, Andrew Alan; Peake, Gregory Merwin

    2003-12-01

    The goal of this LDRD was to investigate III-antimonide/nitride based materials for unique semiconductor properties and applications. Previous to this study, lack of basic information concerning these alloys restricted their use in semiconductor devices. Long wavelength emission on GaAs substrates is of critical importance to telecommunication applications for cost reduction and integration into microsystems. Currently InGaAsN, on a GaAs substrate, is being commercially pursued for the important 1.3 micrometer dispersion minima of silica-glass optical fiber; due, in large part, to previous research at Sandia National Laboratories. However, InGaAsN has not shown great promise for 1.55 micrometer emission which is the low-loss window of single mode optical fiber used in transatlantic fiber. Other important applications for the antimonide/nitride based materials include the base junction of an HBT to reduce the operating voltage which is important for wireless communication links, and for improving the efficiency of a multijunction solar cell. We have undertaken the first comprehensive theoretical, experimental and device study of this material with promising results. Theoretical modeling has identified GaAsSbN to be a similar or potentially superior candidate to InGaAsN for long wavelength emission on GaAs. We have confirmed these predictions by producing emission out to 1.66 micrometers and have achieved edge emitting and VCSEL electroluminescence at 1.3 micrometers. We have also done the first study of the transport properties of this material including mobility, electron/hole mass, and exciton reduced mass. This study has increased the understanding of the III-antimonide/nitride materials enough to warrant consideration for all of the target device applications.

  8. [Alemtuzumab for relapsing-remitting multiple sclerosis. Results of two randomized controlled phase III studies].

    PubMed

    Klotz, L; Meuth, S G; Kieseier, B; Wiendl, H

    2013-08-01

    In November 2012 the results of 2 clinical phase III trials were published which addressed the effects of alemtuzumab in patients with relapsing-remitting multiple sclerosis (MS). In the CARE-MS-I study patients with early untreated MS (EDSS ≤ 3.0, disease duration < 5 years) were included, whereas CARE-MS-II investigated the effects of alemtuzumab in patients with persisting disease activity under standard disease-modifying treatment (EDSS ≤ 5.0, disease duration < 10 years). These groups were compared to patients under treatment with frequently applied interferon β 1a (3 times  44 µg subcutaneous). Both studies clearly demonstrated a superiority of alemtuzumab compared to interferon in terms of reduction of relapse rate as well as the number of new or enlarging T2 lesions and gadolinium-enhancing lesions. Moreover, the CARE-MS-II study showed a significant delay in disease progression by alemtuzumab. The portfolio and the frequency of relevant side effects, such as infusion-related reactions, development of secondary autoimmunity or infections were within the expected range. Taken together these studies confirm the high anti-inflammatory efficacy of alemtuzumab and hence provide the first evidence of superiority of a monotherapy in direct comparison to standard disease-modifying treatment in two phase III trials in relapsing-remitting MS. These data in the context of the mode of action of alemtuzumab provide evidence for the relevance of immune cells, especially T cells, in the pathophysiology of MS. Experience with long-term effects of alemtuzumab, e.g. from the phase II extension trial as well as the side effect profile argue in favor of a sustained reprogramming of the immune system as a consequence of immune cell depletion by alemtuzumab.

  9. [Efficacy of zuclopenthixol acetate on psychotic anxiety evaluated in an open study].

    PubMed

    Romain, J L; Dermain, P; Greslé, P; Grignon, S; Moisan, P; Nore, D; Pech, G; Benyaya, J; Perret, I

    1996-01-01

    The first scale evaluating psychotic anxiety specifically is the "Psychotic Anxiety Scale": PAS was proposed and validated by O. Blin et al. in 1988. Zuclopenthixol acetate formulation is a both rapid and middle prolonged (2-3 days) acting neuroleptic used to start the treatment in an acute episode of the psychotic illness. It has been established as an effective drug for a broad spectrum of symptoms in schizophrenia and other psychosis, but its "angolytic" effect had never been quantified. It was interesting to study the efficacy of zuclopenthixol acetate on psychotic anxiety with PAS during the first 9 days of hospitalisation of psychotic patients. During the study, the clinical evaluation was made with the Psychotic Anxiety Scale (PAS) for the main criteria; Clinical Global Impression (CGI) and the Nordic side effect scale (UKU) for the secondary criteria. Assessments were performed at days, 0, 1, 3, 4, 6, 7 and 9. Zuclopenthixol acetate was administered at Day 0, Day 3, and Day 6. Protocol allowed an additional injection at D1 in case of insufficient efficacy. Forty six patients were included into this open non comparative multicenter study: 23 patients were male and 23 female. Their mean age (X +/- S) was 32 +/- 10 years, and according to DSM III-R, 28 of them got schizophrenia diagnosis, 13 suffered from brief psychotic disorder and 3 from schizophreniform disorder (diagnosis was missing for two subjects). The mean dosage of zuclopenthixol acetate by injection, foreseen in the protocol, was between 126 to 138 mg. Four patients were treated with high dose: more than 800 mg during the 9 days of the study and 6 patients had 5 injections or more. Between D0 and D9, the total PAS score decreased from 63 (from moderated to severe anxiety) to 25 (absence of anxiety) and the reduction of score was statistically significant from 24 hours after the first injection (p < 0.01). Various items analysis of PAS has showed a statistically significant reduction from 24 hours

  10. A Comparative Study of Student Support Services of Allama Iqbal Open University and the Open University of Sri Lanka

    ERIC Educational Resources Information Center

    Gujjar, Aijaz Ahmed; Chaudhry, Bushra Naoreen; Chaudhry, Amtul Hafeez

    2009-01-01

    This paper attempts to compare the availability, quality, similarities and differences in student support services offered by the Allama Iqbal Open University (AIOU) Pakistan and The Open University of Sri Lanka (OUSL). It also aims to identify and report the deficiencies that students of both the institutions face in the student support services.…

  11. A Comparative Study of Student Support Services of Allama Iqbal Open University and the Open University of Sri Lanka

    ERIC Educational Resources Information Center

    Gujjar, Aijaz Ahmed; Chaudhry, Bushra Naoreen; Chaudhry, Amtul Hafeez

    2009-01-01

    This paper attempts to compare the availability, quality, similarities and differences in student support services offered by the Allama Iqbal Open University (AIOU) Pakistan and The Open University of Sri Lanka (OUSL). It also aims to identify and report the deficiencies that students of both the institutions face in the student support services.…

  12. Who Are the Open Learners? A Comparative Study Profiling Non-Formal Users of Open Educational Resources

    ERIC Educational Resources Information Center

    Farrow, Robert; de los Arcos, Beatriz; Pitt, Rebecca; Weller, Martin

    2015-01-01

    Open educational resources (OER) have been identified as having the potential to extend opportunities for learning to non-formal learners. However, little research has been conducted into the impact of OER on non-formal learners. This paper presents the results of a systematic survey of more than 3,000 users of open educational resources (OER).…

  13. Role of the Open Universities in the Developing World. al-Quds Open University. A Case Study.

    ERIC Educational Resources Information Center

    Salah, Munther

    This paper describes the role of open universities in the developing world, particularly al-Quds Open University (QOU) in Jordan which serves Palestinians. An introduction notes the rapid expansion in higher education enrollment in the developing world and the demand for education due to changing labor conditions. The paper goes on to compare…

  14. Adsorption of N/S heterocycles in the flexible metal-organic framework MIL-53(Fe(III)) studied by in situ energy dispersive X-ray diffraction.

    PubMed

    Van de Voorde, Ben; Munn, Alexis S; Guillou, Nathalie; Millange, Franck; De Vos, Dirk E; Walton, Richard I

    2013-06-14

    The adsorption of N/S-containing heterocyclic organic molecules in the flexible iron(III) terephthalate MIL-53, Fe(III)(OH)(0.6)F(0.4)(O2C-C6H4-CO2)·(H2O), from the liquid phase was studied with in situ energy dispersive X-ray diffraction (EDXRD), in order to follow the adsorption-induced expansion of the structure. For comparison with the diffraction data, liquid phase adsorption isotherms were recorded for uptake of benzothiophene, benzothiazole and indole in isopropanol and in heptane. The solvent not only influences pore opening but is also a competing guest. The in situ EDXRD experiments allow the kinetics of guest uptake and the competition with solvent to be monitored directly. Indole uptake is limited; this adsorbate is barely capable of opening the closed, either hydrated or dehydrated, MIL-53(Fe) structure, or of penetrating the isopropanol-containing material in the concentration range under study. When isopropanol is used as a solvent, the guest molecules benzothiophene and benzothiazole must be present at a certain threshold concentration before substantial adsorption into the metal-organic framework takes place, eventually resulting in full opening of the structure. The fully expanded structures of benzothiophene or benzothiazole loaded MIL-53(Fe) materials have Imcm symmetry and a unit cell volume of ca. 1600 Å(3), and upon uptake of the guest molecules by the closed form (unit cell volume ~1000 Å(3)) no intermediate crystalline phases are seen. Successful uptake by MIL-53(Fe) requires that the adsorbate is primarily a good hydrogen bond acceptor; additionally, based on UV-visible spectroscopy, a charge-transfer interaction between the S atoms of benzothiophene and the aromatic rings in the MOF pore wall is proposed.

  15. Molecular interactions between Geobacter sulfurreducens triheme cytochromes and the electron acceptor Fe(iii) citrate studied by NMR.

    PubMed

    Ferreira, Marisa R; Dantas, Joana M; Salgueiro, Carlos A

    2017-02-14

    Proteomic and genetic studies have identified a family of five triheme cytochromes (PpcA-E) that are essential in the iron respiratory pathways of Geobacter sulfurreducens. These include the reduction of Fe(iii) soluble chelated forms or Fe(iii) oxides, which can be used as terminal acceptors by G. sulfurreducens. The relevance of these cytochromes in the respiratory pathways of soluble or insoluble forms of iron is quite distinct. In fact, while PpcD had a higher abundance in the Fe(iii) oxides supplanted G. sulfurreducens cultures, PpcA, PpcB and PpcE were important in Fe(iii) citrate supplanted cultures. Based on these observations we probed the molecular interactions between these cytochromes and Fe(iii) citrate by NMR spectroscopy. NMR spectra were recorded for natural abundance and (15)N-enriched PpcA, PpcB or PpcE samples at increasing amounts of Fe(iii) citrate. The addition of this molecule caused pronounced perturbations on the line width of the protein's NMR signals, which were used to map the interaction region between each cytochrome and the Fe(iii) citrate molecule. The perturbations on the NMR signals corresponding to the backbone NH and heme methyl substituents showed that complex interfaces consist of a well-defined patch, which surrounds the more solvent-exposed heme IV methyl groups in each cytochrome. Overall, this study provides for the first time a clear illustration of the formation of an electron transfer complex between Fe(iii) citrate and G. sulfurreducens triheme cytochromes, shown to be crucial in this respiratory pathway.

  16. Crystal structure of K0.75[Fe(II) 3.75Fe(III) 1.25(HPO3)6]·0.5H2O, an open-framework iron phosphite with mixed-valent Fe(II)/Fe(III) ions.

    PubMed

    Larrea, Edurne S; Mesa, José Luis; Legarra, Estibaliz; Aguayo, Andrés Tomás; Arriortua, Maria Isabel

    2016-01-01

    Single crystals of the title compound, potassium hexa-phosphito-penta-ferrate(II,III) hemihydrate, K0.75[Fe(II) 3.75Fe(III) 1.25(HPO3)6]·0.5H2O, were grown under mild hydro-thermal conditions. The crystal structure is isotypic with Li1.43[Fe(II) 4.43Fe(III) 0.57(HPO3)6]·1.5H2O and (NH4)2[Fe(II) 5(HPO3)6] and exhibits a [Fe(II) 3.75Fe(III) 1.25(HPO3)6](0.75-) open framework with disordered K(+) (occupancy 3/4) as counter-cations. The anionic framework is based on (001) sheets of two [FeO6] octa-hedra (one with point group symmetry 3.. and one with point group symmetry .2.) linked along [001] through [HPO3](2-) oxoanions. Each sheet is constructed from 12-membered rings of edge-sharing [FeO6] octa-hedra, giving rise to channels with a radius of ca 3.1 Å where the K(+) cations and likewise disordered water mol-ecules (occupancy 1/4) are located. O⋯O contacts between the water mol-ecule and framework O atoms of 2.864 (5) Å indicate hydrogen-bonding inter-actions of medium strength. The infrared spectrum of the compound shows vibrational bands typical for phosphite and water groups. The Mössbauer spectrum is in accordance with the presence of Fe(II) and Fe(III) ions.

  17. Crystal structure of K0.75[FeII 3.75FeIII 1.25(HPO3)6]·0.5H2O, an open-framework iron phosphite with mixed-valent FeII/FeIII ions

    PubMed Central

    Larrea, Edurne S.; Mesa, José Luis; Legarra, Estibaliz; Aguayo, Andrés Tomás; Arriortua, Maria Isabel

    2016-01-01

    Single crystals of the title compound, potassium hexa­phosphito­penta­ferrate(II,III) hemihydrate, K0.75[FeII 3.75FeIII 1.25(HPO3)6]·0.5H2O, were grown under mild hydro­thermal conditions. The crystal structure is isotypic with Li1.43[FeII 4.43FeIII 0.57(HPO3)6]·1.5H2O and (NH4)2[FeII 5(HPO3)6] and exhibits a [FeII 3.75FeIII 1.25(HPO3)6]0.75− open framework with disordered K+ (occupancy 3/4) as counter-cations. The anionic framework is based on (001) sheets of two [FeO6] octa­hedra (one with point group symmetry 3.. and one with point group symmetry .2.) linked along [001] through [HPO3]2− oxoanions. Each sheet is constructed from 12-membered rings of edge-sharing [FeO6] octa­hedra, giving rise to channels with a radius of ca 3.1 Å where the K+ cations and likewise disordered water mol­ecules (occupancy 1/4) are located. O⋯O contacts between the water mol­ecule and framework O atoms of 2.864 (5) Å indicate hydrogen-bonding inter­actions of medium strength. The infrared spectrum of the compound shows vibrational bands typical for phosphite and water groups. The Mössbauer spectrum is in accordance with the presence of FeII and FeIII ions. PMID:26870587

  18. Postoperative prophylactic hepatic arterial infusion chemotherapy for stage III colorectal cancer: a retrospective study

    PubMed Central

    Wang, Yao; Sun, Xin Rong; Feng, Wen Ming; Bao, Ying; Zheng, Yin Yuan

    2016-01-01

    Background Radical resection is the main treatment for colorectal cancer (CRC), but metastasis or recurrence is common in which liver metastasis accounted for 83% of the cases. Therefore, the prognosis of patients with advanced CRC may be improved if liver metastasis is prevented. This study aims to investigate the efficacy of hepatic arterial infusion chemotherapy (HAIC) on liver metastases of stage III CRC patients after curative resection. Methods Between 2002 and 2008, 287 stage III CRC patients who had undergone radical resection were included in this study. According to postoperative adjuvant chemotherapy modality, these patients were divided into two groups. Patients in the combined therapy group received two cycles of HAIC plus four cycles of systemic chemotherapy, while patients in the monotherapy group received six cycles of systemic chemotherapy alone. The HAIC regimen consisted of hepatic arterial infusion of oxaliplatin (OXA, 85 mg/m2) on day 1 and 5-fluorouracil (5-FU, 2,400 mg/m2) on days 2 and 3 followed by a vein infusion of folinic acid (FA, 200 mg/m2) as a 2-hour infusion on days 2 and 3. The systemic chemotherapy regimen consisted of a 2-hour infusion of OXA (85 mg/m2) on day 1 followed by FA (200 mg/m2) as a 2-hour infusion on days 2 and 3, and by 5-FU (2,400 mg/m2) as a 48-hour infusion. This was repeated every 4 weeks. All cases were followed up for 5 years or until death. The 5-year overall survival, disease-free survival, liver metastases-free survival, and the overall liver metastases rates were retrospectively compared. Results Significant differences were found in the 5-year overall survival (combined therapy, 70.71%; monotherapy, 57.14%; P=0.014), disease-free survival (combined therapy, 69.29%; monotherapy, 55.78%; P=0.021), and liver metastases-free survival rates (combined therapy, 70%; monotherapy, 56.46%; P=0.019). Conclusion Prophylactic adjuvant HAIC can prevent metachronous liver metastases and improve the prognosis of patients

  19. Synthesis, structural characterization, luminescent properties and theoretical study of three novel lanthanide metal-organic frameworks of Ho(III), Gd(III) and Eu(III) with 2,5-thiophenedicarboxylate anion

    SciTech Connect

    Marques, Lippy F.; Correa, Charlane C.; Ribeiro, Sidney J.L.; Santos, Molíria V. dos; Dutra, José Diogo L.; Freire, Ricardo O.; Machado, Flávia C.

    2015-07-15

    In this paper, the synthesis of three new metal-organic frameworks of lanthanides (LnMOFs) ([Ln{sub 2}(2,5-tdc){sub 3}(dmso){sub 2}]·H{sub 2}O){sub n} (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. Crystal structure of (1) reveals that each lanthanide ion is seven-coordinated by oxygen atoms in an overall distorted capped trigonal – prismatic geometry. The 2,5-tdc{sup 2−} ligands connect four Ln(III) centers, adopting (κ{sup 1}–κ{sup 1})–(κ{sup 1}–κ{sup 1})–μ{sub 4} coordination mode, generating an 8-connected uninodal 3D network. In addition, theoretical studies for Eu(III) complex were performed using the Sparkle model for lanthanide complexes. - Graphical abstract: Three new metal-organic frameworks of lanthanides (LnMOFs) ([Ln{sub 2}(2,5-tdc){sub 3}(dmso){sub 2}]·H{sub 2}O){sub n} (Ln=Ho (1); Gd (2); Eu (3); 2,5-tdc=2,5-thiophenedicarboxylate anion; dmso=dimethylsulfoxide), were synthesized and their complete characterization, including single crystal X-ray diffraction, FTIR spectroscopy and thermogravimetric analysis are reported. In especial, photophysical properties of Eu(III) complex have been studied in detail via both theoretical and experimental approaches. - Highlights: • Three new LnMOFs were synthesized and fully characterized. • Ho{sup 3+}, Gd{sup 3+} and Eu{sup 3+} complexes photoluminescence properties were investigated. • Theoretical approaches for Eu{sup 3+} complex luminescence has been performed. • An energy level diagram is used to establish the ligand-to-metal energy transfer. • These metal−organic frameworks can act as light conversion molecular devices.

  20. Phase II open label study of valproic acid in spinal muscular atrophy.

    PubMed

    Swoboda, Kathryn J; Scott, Charles B; Reyna, Sandra P; Prior, Thomas W; LaSalle, Bernard; Sorenson, Susan L; Wood, Janine; Acsadi, Gyula; Crawford, Thomas O; Kissel, John T; Krosschell, Kristin J; D'Anjou, Guy; Bromberg, Mark B; Schroth, Mary K; Chan, Gary M; Elsheikh, Bakri; Simard, Louise R

    2009-01-01

    Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in 42 subjects with SMA to assess safety and explore potential outcome measures to help guide design of future controlled clinical trials. Subjects included 2 SMA type I ages 2-3 years, 29 SMA type II ages 2-14 years and 11 type III ages 2-31 years, recruited from a natural history study. VPA was well-tolerated and without evident hepatotoxicity. Carnitine depletion was frequent and temporally associated with increased weakness in two subjects. Exploratory outcome measures included assessment of gross motor function via the modified Hammersmith Functional Motor Scale (MHFMS), electrophysiologic measures of innervation including maximum ulnar compound muscle action potential (CMAP) amplitudes and motor unit number estimation (MUNE), body composition and bone density via dual-energy X-ray absorptiometry (DEXA), and quantitative blood SMN mRNA levels. Clear decline in motor function occurred in several subjects in association with weight gain; mean fat mass increased without a corresponding increase in lean mass. We observed an increased mean score on the MHFMS scale in 27 subjects with SMA type II (pstudy highlights potential strengths and limitations of various candidate

  1. Phase II Open Label Study of Valproic Acid in Spinal Muscular Atrophy

    PubMed Central

    Swoboda, Kathryn J.; Scott, Charles B.; Reyna, Sandra P.; Prior, Thomas W.; LaSalle, Bernard; Sorenson, Susan L.; Wood, Janine; Acsadi, Gyula; Crawford, Thomas O.; Kissel, John T.; Krosschell, Kristin J.; D'Anjou, Guy; Bromberg, Mark B.; Schroth, Mary K.; Chan, Gary M.; Elsheikh, Bakri; Simard, Louise R.

    2009-01-01

    Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in 42 subjects with SMA to assess safety and explore potential outcome measures to help guide design of future controlled clinical trials. Subjects included 2 SMA type I ages 2–3 years, 29 SMA type II ages 2–14 years and 11 type III ages 2–31 years, recruited from a natural history study. VPA was well-tolerated and without evident hepatotoxicity. Carnitine depletion was frequent and temporally associated with increased weakness in two subjects. Exploratory outcome measures included assessment of gross motor function via the modified Hammersmith Functional Motor Scale (MHFMS), electrophysiologic measures of innervation including maximum ulnar compound muscle action potential (CMAP) amplitudes and motor unit number estimation (MUNE), body composition and bone density via dual-energy X-ray absorptiometry (DEXA), and quantitative blood SMN mRNA levels. Clear decline in motor function occurred in several subjects in association with weight gain; mean fat mass increased without a corresponding increase in lean mass. We observed an increased mean score on the MHFMS scale in 27 subjects with SMA type II (p≤0.001); however, significant improvement was almost entirely restricted to participants <5 years of age. Full length SMN levels were unchanged and Δ7SMN levels were significantly reduced for 2 of 3 treatment visits. In contrast, bone mineral density (p≤0.0036) and maximum ulnar CMAP scores (p≤0.0001) increased significantly. Conclusions While VPA appears safe and well-tolerated in this initial pilot trial, these data suggest that weight gain and carnitine depletion are likely to be significant confounding factors in clinical trials. This study highlights potential strengths and limitations of various

  2. Sutureless open vascular anastomosis connector: An experimental study.

    PubMed

    Kapischke, Matthias; Gerhard, Dietmar; Pries, Alexandra

    2017-02-01

    The objective of this study was to assess the safety of a new developed sutureless vascular adapter system in a porcine model. In five pigs, 4-cm-long polyester prosthesis (6 mm diameter) were implanted and anastomosed with the newly developed adapter proximally and suture anastomosis distally. The integration of the adapter was investigated in comparison to the suture anastomosis. These investigations were performed by light microscopy and scanning electron microscopy. Median operative time for performing the adapter anastomosis was significantly shorter compared to suture anastomosis (66 s vs. 246 s, p < 0.05). Median estimated blood loss during adapter anastomosis implementation was 22.5 mL (range 19.0-25.0 mL) compared to 48.2 mL (range 45.4-63.5 mL, p < 0.05). In five hand-sewn anastomoses, overall eight additional stitches were necessary whereas all adapter anastomoses showed primary leak tightness. This in vivo study shows the technical feasibility of the newly developed adapter.

  3. Antimony(III) and bismuth(III) amides containing pendant N-donor groups--a combined experimental and theoretical study.

    PubMed

    Vránová, Iva; Jambor, Roman; Růžička, Aleš; Hoffmann, Alexander; Herres-Pawlis, Sonja; Dostál, Libor

    2015-01-07

    N,N- and N,N,N-chelated antimony(III) and bismuth(III) chlorides L(1-3)MCl2 1-4 [for L(1): M = Sb (1), for L(2): M = Sb (2) and for L(3): M = Sb (3) and Bi (4)], containing ligands L(1-3) derived from the pyrrole ring (where L(1) = C4H3N-2-(CH[double bond, length as m-dash]N-2',6'-iPr2C6H3), L(2) = C4H2N-2,5-(CH2NMe2)2, L(3) = C4H2N-2,5-(CH2NC4H8)2), were prepared by the treatment of lithium precursors with SbCl3 or BiCl3. Molecular structures 1-4 of were described both in solution (NMR spectroscopy) and in the solid state (single-crystal X-ray diffraction analysis). Structures of 1-4 were also subjected to a density functional theory study.

  4. Structure and conformation of (dibenzyldiaza-18-crown-6)-Nd(III) and Eu(III) thiocyanates: infrared spectroscopic and X-ray crystallographic studies

    NASA Astrophysics Data System (ADS)

    Saleh, Muhammad Idiris; Salhin, Abdussalam; Saad, Bahruddin; Fun, Hoong-Kun

    1999-01-01

    Dibenzyldiaza-18-crown-6 was utilised as a host to accommodate Nd(III) and Eu(III) metal ions together with thiocyanate as counter ion. The crystalline complexes formed were studied for their absorption in the infrared region and their crystalline structure by X-ray diffraction. The coordination of the metal ions to the counter ion and also to the donor atoms of the crown ether was clearly seen from the shift of the absorption band of the pure compound by up to nearly 15 cm -1. From these absorption it was found that each lanthanide ion was coordinated to six donor atoms (2 N and 4 O) from crown ether and three donor atoms, N from NCS -. This nine coordination number complex was found to have the stoichiometry of 1:1:3 (crown ether:lanthanide; NCS -). This ratio was further confirmed by X-ray crystallographic method. The lanthanide thiocyanate salts existed as an isolated (separate) entity in the center of the macrocyclic cavity. The three N atoms surrounded the Ln cation in a nearly planar trigonal arrangement with Ln ion being slightly out of plane. The trigonal plane was perpendicular to and bisects the plane of the macrocycle.

  5. Energy Optimization Modeling of Geothermal Power Plant (Case Study: Darajat Geothermal Field Unit III)

    NASA Astrophysics Data System (ADS)

    Sinaga, R. H. M.; Darmanto, P. S.

    2016-09-01

    Darajat unit III geothermal power plant is developed by PT. Chevron Geothermal Indonesia (CGI). The plant capacity is 121 MW and load 110%. The greatest utilization power is consumed by Hot Well Pump (HWP) and Cooling Tower Fan (CTF). Reducing the utility power can be attempted by utilizing the wet bulb temperature fluctuation. In this study, a modelling process is developed by using Engineering Equation Solver (EES) software version 9.430.The possibility of energy saving is indicated by Specific Steam Consumption (SSC) net in relation to wet bulb temperature fluctuation from 9°C up to 20.5°C. Result shows that the existing daily operation reaches its optimum condition. The installation of Variable Frequency Drive (VFD) could be applied to optimize both utility power of HWP and CTF. The highest gain is obtained by VFD HWP installation as much as 0.80% when wet bulb temperature 18.5 °C.

  6. Synthesis, Physicochemical Properties, and Antimicrobial Studies of Iron (III) Complexes of Ciprofloxacin, Cloxacillin, and Amoxicillin

    PubMed Central

    Ajali, Uzoechi; Ukoha, Pius O.

    2014-01-01

    Iron (III) complexes of ciprofloxacin, amoxicillin, and cloxacillin were synthesized and their aqueous solubility profiles, relative stabilities, and antimicrobial properties were evaluated. The complexes showed improved aqueous solubility when compared to the corresponding ligands. Relative thermal and acid stabilities were determined spectrophotometrically and the results showed that the complexes have enhanced thermal and acid stabilities when compared to the pure ligands. Antimicrobial studies showed that the complexes have decreased activities against most of the tested microorganisms. Ciprofloxacin complex, however, showed almost the same activity as the corresponding ligand. Job's method of continuous variation suggested 1 : 2 metals to ligand stoichiometry for ciprofloxacin complex but 1 : 1 for cloxacillin complex. PMID:25505991

  7. Fluorescence study of lipid bilayer interactions of Eu(III) coordination complexes.

    PubMed

    Kutsenko, Olga K; Trusova, Valeriya M; Gorbenko, Galyna P; Deligeorgiev, Todor; Vasilev, Aleksey; Kaloianova, Stefka; Lesev, Nedyalko

    2011-07-01

    The interaction between Eu(III) tris-β-diketonato coordination complexes (EC), displaying antitumor activity, and lipid vesicles composed of zwitterionic lipid phosphatidylcholine has been studied using fluorescence spectroscopy techniques. To characterize EC-membrane binding, several fluorescent probes, including pyrene, Prodan and 1,6-diphenyl-1,3,5-hexatriene, have been employed. It has been found that EC display effective partitioning into lipid phase, giving rise to structural modifications of both polar and nonpolar lipid bilayer regions, viz. enhancement of membrane hydration and increase in tightness of lipid chain packing. The fact that EC accumulating in lipid bilayer are incapable of inducing significant disruption of membrane structural integrity creates strong prerequisites for development of liposomal nanocarriers of these potential antitumor drugs. Such a possibility is also corroborated by the observation that EC membrane incorporation does not prevent lipid bilayer partitioning of long-wavelength squaraine dyes which represent promising candidates for visualization of liposome biodistribution.

  8. AFB/open cycle gas turbine conceptual design study

    NASA Technical Reports Server (NTRS)

    Dickinson, T. W.; Tashjian, R.

    1983-01-01

    Applications of coal fired atmospheric fluidized bed gas turbine systems in industrial cogeneration are identified. Based on site-specific conceptual designs, the potential benefits of the AFB/gas turbine system were compared with an atmospheric fluidized design steam boiler/steam turbine system. The application of these cogeneration systems at four industrial plant sites is reviewed. A performance and benefit analysis was made along with a study of the representativeness of the sites both in regard to their own industry and compared to industry as a whole. A site was selected for the conceptual design, which included detailed site definition, AFB/gas turbine and AFB/steam turbine cogeneration system designs, detailed cost estimates, and comparative performance and benefit analysis. Market and benefit analyses identified the potential market penetration for the cogeneration technologies and quantified the potential benefits.

  9. Topical nicotinamide for seborrheic dermatitis: an open randomized study.

    PubMed

    Fabbrocini, Gabriella; Cantelli, Mariateresa; Monfrecola, Giuseppe

    2014-06-01

    Treatment of seborrheic dermatitis (SD) includes various options with different success and safety limitations. To evaluate the efficacy of topical nicotinamide (NCT) in the treatment of SD. A total of 48 patients with mild to moderate SD of the face were enrolled in the study (36 males and 12 females; age 20-50 years). Patients were randomized into two groups A and B, who were treated once a day with topical administration of NCT 4% cream and with the vehicle without NCT (placebo), respectively. Clinical measures were assessed by erythema, scaling, and infiltration, which were evaluated using a four-point scale 0-3 before starting treatment and after 2, 6, and 12 weeks' therapy. In comparison with baseline, a reduction of 75% of the total score was observed in patients treated with NCT, whereas for placebo-treated patients the reduction was of 35% (p < 0.05). Topical NCT 4% can have a potential for the treatment of SD.

  10. Multiquark study of exotic open bottom baryonic states

    NASA Astrophysics Data System (ADS)

    Caramés, T. F.; Valcarce, A.

    2017-05-01

    We present a simultaneous study of baryon-meson systems containing a bottom degree of freedom, either as a quark or as an antiquark. This produces two different types of structures: the N B system, subject to quark antisymmetry effects and whose existence would generate explicit exotic states; and the N B ¯ system, subject to the coupling to heavy baryon-light meson systems and whose existence would represent a higher Fock space component of the bottom baryon spectrum. Both systems have been studied within the framework of a full-fledged chiral constituent quark model tuned in the description of the baryon and meson spectra and the N N interaction. Although the masses of the constituents are larger than its partners in the charm sector, we do not observe a proliferation of bound states. This is due to the coupled-channel mechanism that governs the dynamics for most spin-isospin channels, and requires, in order to have a bound state, several conditions that are difficult to be met at the same time. Our results point to the existence of a deep N B bound state in the (T )JP=(2 )3 /2- channel, as a consequence of the reduction of the mass difference between pseudoscalar and vector mesons when the mass of the heavy quark increases. The same effect gives rise to a resonance at threshold in the (T )JP=(0 )1 /2- channel, the best candidate for an exotic state among the channels that do not contain a Δ isobar. In the N B ¯ system, a few channels may lodge molecular or compact hadrons with a five-quark structure, being specially suited the (T )JP=(0 )1 /2- and (T )JP=(1 )5 /2- channels.

  11. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

    PubMed Central

    Ejidike, Ikechukwu P.

    2016-01-01

    Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)]. PMID:27597814

  12. Real-world cost-effectiveness of laparoscopy versus open colectomy for colon cancer: a nationwide population-based study.

    PubMed

    Liao, Chih-Hsien; Tan, Elise Chia-Hui; Chen, Chien-Chih; Yang, Ming-Chin

    2017-04-01

    Laparoscopic colectomy is increasingly being adopted for the treatment of colon cancer; however, the long-term effectiveness of this approach in a real-world clinical setting has yet to be verified. This study aims to compare the effectiveness and costs associated with laparoscopic and open colectomy from the perspective of the National Health Insurance (NHI) system in Taiwan. A nationwide population-based colon cancer cohort was observed by linking the Taiwan Cancer Registry, claims data from NHI system, and the National Death Registry. Adult patients with Stage I to Stage III colon cancer who underwent primary cancer resection using either laparoscopy or open colectomy between 2009 and 2011 were included. A propensity score-matched cohort (1745 pairs) was applied to examine three clinical endpoints: overall survival, recurrence-free survival, and disease-free survival within 2 years after the operation. To comply with the perspective as well as the analytic horizon of the study, we limited the research to NHI claims from the study population for the corresponding time period. The health outcomes and net monetary benefits were verified by multivariate mixed-effect models. This analysis revealed that laparoscopy resulted in longer overall survival (adjusted difference 16.8 days, 95 % CI 7.3-26.2), recurrence-free survival (16.8 days, 5.0-28.6) and disease-free survival (26.4 days, 7.4-45.4), compared to open colectomy at 2 years post-op. Laparoscopy also led to a significantly shorter length of stay (3.2 days, 2.4-3.9) and lower index hospitalization costs (US$ 455, 181-729) than open colectomy; however, no differences in costs were observed over the long term. Overall, laparoscopy was more cost-effective than open colectomy under various willingness-to-pay thresholds in the setting of the Taiwan NHI. The continued adoption of laparoscopy in primary curable colon cancer resection is expected to reduce health care costs over the short term while providing

  13. Photoisomerization among ring-open merocyanines. II. A computational study

    NASA Astrophysics Data System (ADS)

    Walter, Christof; Ruetzel, Stefan; Diekmann, Meike; Nuernberger, Patrick; Brixner, Tobias; Engels, Bernd

    2014-06-01

    The photochemical isomerization of the trans-trans-cis to the trans-trans-trans isomer of the merocyanine form of 6-nitro BIPS, which has been studied with femtosecond transient absorption spectroscopy [S. Ruetzel, M. Diekmann, P. Nuernberger, C. Walter, B. Engels, and T. Brixner, J. Chem. Phys. 140, 224310 (2014)], is investigated using time-dependent density functional theory in conjunction with polarizable continuum models. Benchmark calculations against SCS-ADC(2) evaluate the applicability of the CAM-B3LYP functional. Apart from a relaxed scan in the ground state with additional computation of the corresponding excitation energies, which produces the excited-state surface vertical to the ground-state isomerization coordinate, a relaxed scan in the S1 gives insight into the geometric changes orthogonal to the reaction coordinate and the fluorescence conditions. The shape of the potential energy surface (PES) along the reaction coordinate is found to be highly sensitive to solvation effects, with the method of solvation (linear response vs. state-specific) being critical. The shape of the PES as well as the computed harmonic frequencies in the S1 minima are in line with the experimental results and offer a straightforward interpretation.

  14. Photoisomerization among ring-open merocyanines. II. A computational study.

    PubMed

    Walter, Christof; Ruetzel, Stefan; Diekmann, Meike; Nuernberger, Patrick; Brixner, Tobias; Engels, Bernd

    2014-06-14

    The photochemical isomerization of the trans-trans-cis to the trans-trans-trans isomer of the merocyanine form of 6-nitro BIPS, which has been studied with femtosecond transient absorption spectroscopy [S. Ruetzel, M. Diekmann, P. Nuernberger, C. Walter, B. Engels, and T. Brixner, J. Chem. Phys. 140, 224310 (2014)], is investigated using time-dependent density functional theory in conjunction with polarizable continuum models. Benchmark calculations against SCS-ADC(2) evaluate the applicability of the CAM-B3LYP functional. Apart from a relaxed scan in the ground state with additional computation of the corresponding excitation energies, which produces the excited-state surface vertical to the ground-state isomerization coordinate, a relaxed scan in the S1 gives insight into the geometric changes orthogonal to the reaction coordinate and the fluorescence conditions. The shape of the potential energy surface (PES) along the reaction coordinate is found to be highly sensitive to solvation effects, with the method of solvation (linear response vs. state-specific) being critical. The shape of the PES as well as the computed harmonic frequencies in the S1 minima are in line with the experimental results and offer a straightforward interpretation.

  15. Glycerol fermentation by (open) mixed cultures: a chemostat study.

    PubMed

    Temudo, Margarida F; Poldermans, Rolf; Kleerebezem, Robbert; van Loosdrecht, Mark C M

    2008-08-15

    Glycerol is an important byproduct of bioethanol and biodiesel production processes. This study aims to evaluate its potential application in mixed culture fermentation processes to produce bulk chemicals. Two chemostat reactors were operated in parallel, one fed with glycerol and the other with glucose. Both reactors operated at a pH of 8 and a dilution rate of 0.1 h(-1). Glycerol was mainly converted into ethanol and formate. When operated under substrate limiting conditions, 60% of the substrate carbon was converted into ethanol and formate in a 1:1 ratio. This product spectrum showed sensitivity to the substrate concentration, which partly shifted towards 1,3-propanediol and acetate in a 2:1 ratio at increasing substrate concentrations. Glucose fermentation mainly generated acetate, ethanol and butyrate. At higher substrate concentrations, acetate and ethanol were the dominant products. Co-fermentations of glucose-glycerol were performed with both mixed cultures, previously cultivated on glucose and on glycerol. The product spectrum of the two experiments was very similar: the main products were ethanol and butyrate (38% and 34% of the COD converted, respectively). The product spectrum obtained for glucose and glycerol fermentation could be explained based on the general metabolic pathways found for fermentative microorganisms and on the metabolic constraints: maximization of the ATP production rate and balancing the reducing equivalents involved.

  16. TD-DFT study of the light-induced spin crossover of Fe(III) complexes.

    PubMed

    Saureu, Sergi; de Graaf, Coen

    2016-01-14

    Two light-induced spin-crossover Fe(III) compounds have been studied with time-dependent density functional theory (TD-DFT) to investigate the deactivation mechanism and the role of the ligand-field states as intermediates in this process. The B3LYP* functional has previously shown its ability to accurately describe (light-induced) spin-crossover in Fe(II) complexes. Here, we establish its performance for Fe(III) systems using [Fe(qsal)2](+) (Hqsal = 2-[(8-quinolinylimino)methyl]phenol) and [Fe(pap)2](+) (Hpap = 2-(2-pyridylmethyleneamino)phenol) as test cases comparing the B3LYP* results to experimental information and to multiconfigurational wave function results. In addition to rather accurate high spin (HS) and low spin (LS) state geometries, B3LYP* also predicts ligand-to-metal charge transfer (LMCT) states with large oscillator strength in the energy range where the UV-VIS spectrum shows an intense absorption band, whereas optically allowed π-π* excitations on the ligands were calculated at higher energy. Subsequently, we have generated a two-dimensional potential energy surface of the HS and LS states varying the Fe-N and Fe-O distances. LMCT and metal centered (MC) excited states were followed along the approximate minimal energy path that connects the minima of the HS and LS on this surface. The (2)LMCT state has a minimum in the same region as the initial LS state, where we also observe a crossing with the intermediate spin (IS) state. Upon the expansion of the coordination sphere of the Fe(III) ion, the IS state crosses with the HS state and further expansion of the coordination sphere leads to the excited spin state trapping as observed in experiment. The calculation of the intersystem crossing rates reveals that the deactivation from (2)LMCT → IS → HS competes with the (2)LMCT → IS → LS pathway, in line with the low efficiency encountered in experiments.

  17. A comparative study of the biosorption of iron(III)-cyanide complex anions to Rhizopus arrhizus and Chlorella vulgaris

    SciTech Connect

    Aksu, Z.; Calik, A.

    1999-03-01

    In this study a comparative biosorption of iron(III)-cyanide complex anions from aqueous solutions to Rhizopus arrhizus and Chlorella vulgaris was investigated. The iron(III)-cyanide complex ion-binding capacities of the biosorbents were shown as a function of initial pH, initial iron(III)-cyanide complex ion, and biosorbent concentrations. The results indicated that a significant reduction of iron(III)-cyanide complex ions was achieved at pH 13, a highly alkaline condition for both the biosorbents. The maximum loading capacities of the biosorbents were found to be 612.2 mg/g for R.arrhizus at 1,996.2 mg/L initial iron(III)-cyanide complex ion concentration and 387.0 mg/g for C. vulgaris at 845.4 mg/L initial iron(III)-cyanide complex ion concentration at this pH. The Freundlich, Langmuir, and Redlich-Peterson adsorption models were fitted to the equilibrium data at pH 3, 7, and 13. The equilibrium data of the biosorbents could be best fitted by all the adsorption models over the entire concentration range at pH 13.

  18. Study of Adsorption Property of Ga(III) onto Strongly Basic Resin for Ga Extraction from Bayer Liquor

    NASA Astrophysics Data System (ADS)

    Zhao, Zhuo; Yang, Yongxiang; Lu, Hao; Hua, Zhongsheng; Ma, Xiaoling

    Ion-exchange is the main technology used in industry for gallium recovery from Bayer liquor, the largest gallium production resource. However, the co-extraction of vanadium and the degradation of resins are the major issues. Further investigations related to fundamental theory are needed. This paper reports the study of the adsorption properties of a strongly basic resin having a combination of one =NOH group and another active group -NH2 for Ga(III) extraction. The influence of operational conditions such as contact time, initial Ga(III) concentration and temperature on Ga(III) adsorption were extensively investigated. The results revealed that the resin has high adsorption capacity and Ga(III) selectivity. The optimal adsorption condition was obtained at temperatures of 40-50°C and contact time of 40-60 min. The Ga(III) adsorption data on the resin fit well with the pseudo second-order kinetics. Langmuir and Freundlich models were used to describe Ga(III) adsorption isotherms on the resin.

  19. Eu(III) sorption to TiO2 (anatase and rutile): batch, XPS, and EXAFS studies.

    PubMed

    Tan, Xiaoli; Fan, Qiaohui; Wang, Xiangke; Grambow, Bernd

    2009-05-01

    The sorption of Eu(III) on anatase and rutile was studied as a function of ionic strength, humic acid (HA, 7.5 mg/L), and electrolyte anions over a large range of pH (2-12). The presence of HA significantly affected Eu(III) sorption to anatase and rutile. The sorption of Eu(III) on anatase and rutile was independent of ionic strength. Results of an X-ray photoelectron spectroscopy (XPS) analysis showed that Eu(III) was chemically present within the near-surface of TiO2 due to the formation of triple bond SOEu and triple bond SOHAEu complexes. An extended X-ray absorption fine structure (EXAFS) technique was applied to characterize the local structural environment of the adsorbed Eu(III), and the results indicated that Eu(III) was bound to about seven or eight O atoms at a distance of about 2.40 A. The functional groups of surface-bound HA were expected to be involved in the sorption process. The measured Eu-Ti distance confirmed the formation of inner-sphere sorption complexes on a TiO2 surface.

  20. Experimental Studies on the Mechanical Behaviour of Rock Joints with Various Openings

    NASA Astrophysics Data System (ADS)

    Li, Y.; Oh, J.; Mitra, R.; Hebblewhite, B.

    2016-03-01

    The mechanical behaviour of rough joints is markedly affected by the degree of joint opening. A systematic experimental study was conducted to investigate the effect of the initial opening on both normal and shear deformations of rock joints. Two types of joints with triangular asperities were produced in the laboratory and subjected to compression tests and direct shear tests with different initial opening values. The results showed that opened rock joints allow much greater normal closure and result in much lower normal stiffness. A semi-logarithmic law incorporating the degree of interlocking is proposed to describe the normal deformation of opened rock joints. The proposed equation agrees well with the experimental results. Additionally, the results of direct shear tests demonstrated that shear strength and dilation are reduced because of reduced involvement of and increased damage to asperities in the process of shearing. The results indicate that constitutive models of rock joints that consider the true asperity contact area can be used to predict shear resistance along opened rock joints. Because rock masses are loosened and rock joints become open after excavation, the model suggested in this study can be incorporated into numerical procedures such as finite-element or discrete-element methods. Use of the model could then increase the accuracy and reliability of stability predictions for rock masses under excavation.

  1. Surface X-Ray Diffraction Results on the III-V Droplet Heteroepitaxy Growth Process for Quantum Dots: Recent Understanding and Open Questions

    SciTech Connect

    Cohen, Eyal; Elfassy, Naomi; Koplovitz, Guy; Yochelis, Shira; Shusterman, Sergey; Kumah, Divine P.; Yacoby, Yizhak; Clarke, Roy; Paltiel, Yossi

    2011-11-08

    In recent years, epitaxial growth of self-assembled quantum dots has offered a way to incorporate new properties into existing solid state devices. Although the droplet heteroepitaxy method is relatively complex, it is quite relaxed with respect to the material combinations that can be used. This offers great flexibility in the systems that can be achieved. In this paper we review the structure and composition of a number of quantum dot systems grown by the droplet heteroepitaxy method, emphasizing the insights that these experiments provide with respect to the growth process. Detailed structural and composition information has been obtained using surface X-ray diffraction analyzed by the COBRA phase retrieval method. A number of interesting phenomena have been observed: penetration of the dots into the substrate (“nano-drilling”) is often encountered; interdiffusion and intermixing already start when the group III droplets are deposited, and structure and composition may be very different from the one initially intended.

  2. Surface X-Ray Diffraction Results on the III-V Droplet Heteroepitaxy Growth Process for Quantum Dots: Recent Understanding and Open Questions

    SciTech Connect

    Cohen, Eyal; Elfassy, Naomi; Koplovitz, Guy; Yochelis, Shira; Shusterman, Sergey; Kumah, Divine P.; Yacoby, Yizhak; Clarke, Roy; Paltiel, Yossi

    2012-04-24

    In recent years, epitaxial growth of self-assembled quantum dots has offered a way to incorporate new properties into existing solid state devices. Although the droplet heteroepitaxy method is relatively complex, it is quite relaxed with respect to the material combinations that can be used. This offers great flexibility in the systems that can be achieved. In this paper we review the structure and composition of a number of quantum dot systems grown by the droplet heteroepitaxy method, emphasizing the insights that these experiments provide with respect to the growth process. Detailed structural and composition information has been obtained using surface X-ray diffraction analyzed by the COBRA phase retrieval method. A number of interesting phenomena have been observed: penetration of the dots into the substrate ('nano-drilling') is often encountered; interdiffusion and intermixing already start when the group III droplets are deposited, and structure and composition may be very different from the one initially intended.

  3. Spectroscopic studies on the interaction of quercetin-terbium(III) complex with calf thymus DNA.

    PubMed

    Dehghan, Gholamreza; Dolatabadi, Jafar Ezzati Nazhad; Jouyban, Abolghasem; Zeynali, Karim Asadpour; Ahmadi, Seyed Mojtaba; Kashanian, Soheila

    2011-03-01

    The interaction of native calf thymus DNA (CT-DNA) with quercetin-terbium(III) [Q-Tb(III)] complex at physiological pH was monitored by UV absorption spectrophotometry, circular dichroism, fluorescence spectroscopy, and viscosimetric techniques. The complex displays binding properties to the CT-DNA and was found to interact with CT-DNA through outside binding, demonstrated by a hypochromic effect of Q-Tb(III) on the UV spectra of CT-DNA and the calculated association constants (K). Also, decrease in the specific viscosity of CT-DNA, decrease in the fluorescence intensity of Q-Tb(III) solutions in the presence of increasing amounts of CT-DNA, and detectable changes in the circular dichroism spectrum of CT-DNA are other evidences to indicate that Q-Tb(III) complex interact with CT-DNA through outside binding.

  4. Pepper Heat Shock Protein 70a Interacts with the Type III Effector AvrBsT and Triggers Plant Cell Death and Immunity1[OPEN

    PubMed Central

    Kim, Nak Hyun; Hwang, Byung Kook

    2015-01-01

    Heat shock proteins (HSPs) function as molecular chaperones and are essential for the maintenance and/or restoration of protein homeostasis. The genus Xanthomonas type III effector protein AvrBsT induces hypersensitive cell death in pepper (Capsicum annuum). Here, we report the identification of the pepper CaHSP70a as an AvrBsT-interacting protein. Bimolecular fluorescence complementation and coimmunoprecipitation assays confirm the specific interaction between CaHSP70a and AvrBsT in planta. The CaHSP70a peptide-binding domain is essential for its interaction with AvrBsT. Heat stress (37°C) and Xanthomonas campestris pv vesicatoria (Xcv) infection distinctly induce CaHSP70a in pepper leaves. Cytoplasmic CaHSP70a proteins significantly accumulate in pepper leaves to induce the hypersensitive cell death response by Xcv (avrBsT) infection. Transient CaHSP70a overexpression induces hypersensitive cell death under heat stress, which is accompanied by strong induction of defense- and cell death-related genes. The CaHSP70a peptide-binding domain and ATPase-binding domain are required to trigger cell death under heat stress. Transient coexpression of CaHSP70a and avrBsT leads to cytoplasmic localization of the CaHSP70a-AvrBsT complex and significantly enhances avrBsT-triggered cell death in Nicotiana benthamiana. CaHSP70a silencing in pepper enhances Xcv growth but disrupts the reactive oxygen species burst and cell death response during Xcv infection. Expression of some defense marker genes is significantly reduced in CaHSP70a-silenced leaves, with lower levels of the defense hormones salicylic acid and jasmonic acid. Together, these results suggest that CaHSP70a interacts with the type III effector AvrBsT and is required for cell death and immunity in plants. PMID:25491184

  5. Cellular uptake of PLA nanoparticles studied by light and electron microscopy: synthesis, characterization and biocompatibility studies using an iridium(III) complex as correlative label.

    PubMed

    Reifarth, Martin; Pretzel, David; Schubert, Stephanie; Weber, Christine; Heintzmann, Rainer; Hoeppener, Stephanie; Schubert, Ulrich S

    2016-03-21

    We present the synthesis of polylactide by ring-opening polymerization using a luminescent iridium(III) complex acting as initiator. The polymer was formulated into nanoparticles, which were taken up by HEK-293 cells. We could show that the particles provided an appropriate contrast in both superresolution fluorescence and electron microscopy, and, moreover, are non-toxic, in contrast to the free iridium complex.

  6. Sorption of Eu(III) on granite: EPMA, LA-ICP-MS, batch and modeling studies.

    PubMed

    Fukushi, Keisuke; Hasegawa, Yusuke; Maeda, Koushi; Aoi, Yusuke; Tamura, Akihiro; Arai, Shoji; Yamamoto, Yuhei; Aosai, Daisuke; Mizuno, Takashi

    2013-11-19

    Eu(III) sorption on granite was assessed using combined microscopic and macroscopic approaches in neutral to acidic conditions where the mobility of Eu(III) is generally considered to be high. Polished thin sections of the granite were reacted with solutions containing 10 μM of Eu(III) and were analyzed using EPMA and LA-ICP-MS. On most of the biotite grains, Eu enrichment up to 6 wt % was observed. The Eu-enriched parts of biotite commonly lose K, which is the interlayer cation of biotite, indicating that the sorption mode of Eu(III) by the biotite is cation exchange in the interlayer. The distributions of Eu appeared along the original cracks of the biotite. Those occurrences indicate that the prior water-rock interaction along the cracks engendered modification of biotite to possess affinity to the Eu(III). Batch Eu(III) sorption experiments on granite and biotite powders were conducted as functions of pH, Eu(III) loading, and ionic strength. The macroscopic sorption behavior of biotite was consistent with that of granite. At pH > 4, there was little pH dependence but strong ionic strength dependence of Eu(III) sorption. At pH < 4, the sorption of Eu(III) abruptly decreased with decreased pH. The sorption behavior at pH > 4 was reproducible reasonably by the modeling considering single-site cation exchange reactions. The decrease of Eu(III) sorption at pH < 4 was explained by the occupation of exchangeable sites by dissolved cationic species such as Al and Fe from granite and biotite in low-pH conditions. Granites are complex mineral assemblages. However, the combined microscopic and macroscopic approaches revealed that elementary reactions by a single mineral phase can be representative of the bulk sorption reaction in complex mineral assemblages.

  7. Spectroscopic studies on the interaction of morin-Eu(III) complex with calf thymus DNA

    NASA Astrophysics Data System (ADS)

    Zhang, Guowen; Guo, Jinbao; Pan, Junhui; Chen, Xiuxia; Wang, Junjie

    2009-04-01

    The interaction between morin-Eu(III) complex and calf thymus DNA in physiological buffer (pH 7.4) was investigated using UV-vis spectrophotometry, fluorescence spectroscopy, viscosity measurements and DNA melting techniques. Hypochromicity and red shift of the absorption spectra of morin-Eu(III) complex were observed in the presence of DNA, and the fluorescence intensity of morin-Eu(III) complex was greatly enhanced with the addition of DNA. Moreover, fluorescence quenching and blue shift of the emission peak were seen in the DNA-ethidium bromide (EB) system when morin-Eu(III) complex was added. The relative viscosity of DNA increased with the addition of morin-Eu(III) complex, whereas the value of melting temperature of DNA-EB system decreased in the presence of morin-Eu(III) complex. All these results indicated that morin-Eu(III) complex can bind to DNA and the major binding mode is intercalative binding. The 3:1 morin:Eu(III) complex (estimated binding constant = 2.36 × 10 6 L mol -1) is stabilized by intercalation into the DNA. The calculated binding constants of morin-Eu(III) complex with DNA at 292, 301 and 310 K were 7.47 × 10 4, 8.89 × 10 4 and 1.13 × 10 5 L mol -1, respectively. The thermodynamic parameters were also obtained: Δ H θ was 20.14 kJ mol -1 > 0 and Δ S θ was 161.70 J mol -1 K -1 > 0, suggesting that hydrophobic force plays a major role in the binding of morin-Eu(III) complex to DNA.

  8. Hydrologic studies in wells open through large intervals. Annual report, 1992

    SciTech Connect

    Not Available

    1992-12-31

    This report describes and summarizes activities, data, and preliminary data interpretation from the INEL Oversight Program R&D-1 project titled ``Hydrologic Studies In Wells Open Through Large Intervals.`` The project is designed to use a straddle-packer system to isolate, hydraulically test, and sample specific intervals of monitoring wells that are open (uncased, unscreened) over large intervals of the Snake River Plain aquifer. The objectives of the project are to determine and compare vertical variations in water quality and aquifer properties that have previously only been determined in an integrated fashion over the entire thickness of the open interval of the observation wells.

  9. Vibration transmission through rolling element bearings. Part III: Geared rotor system studies

    NASA Astrophysics Data System (ADS)

    Lim, T. C.; Singh, R.

    1991-11-01

    This paper extends the proposed bearing matrix formulation of Parts I and II to analyze the overall dynamics of a geared rotor system which includes a spur gear pair, shafts, rolling element bearing, a prime mover and a load (attached to the geared rotor system through flexible torsional couplings), a rigid or flexible casing, and compliant or massive mounts. Linear time-invariant, discrete dynamic models of a generic geared rotor system with proportional viscous damping are developed, by using lumped parameter and dynamic finite element techniques, which are then used to predict the vibration transmissibility through bearings and mounts, casing vibration motion, and dynamic response of the internal rotating system. Each rotating shaft is modeled as an Euler beam in the lumped parameter model and as a Timoshenko beam in the dynamic finite element model, but the gyroscopic moment is not included. Eigensolution and forced harmonic response studies due to rotating mass unbalance or kinematic transmission error excitation for the following example cases are obtained by using the formulation, and the results are compared with those of simple models currently available in the literature and/or experiment: case I, a single-stage rotor system with flexibly mounted rigid casing consisting of two bearings as a special case of the geared rotor system; case II, a spur gear pair drive supported by four bearings installed in a flexibly mounted rigid casing; and case III, an experimental set-up consisting of a high-precision gear and pinion, and four identical rolling element bearings contained in a flexible casing mounted rigidly on a massive foundation. Analytical predictions show that the theory is indeed capable of predicting bearing and mount moment transmissibilities in addition to the force transmissibilities. Also, flexural vibrations of the casing plate are predicted well as the theory is in good agreement with measurements made on case III; such predictions are not

  10. Comparative studies of praseodymium(III) selective sensors based on newly synthesized Schiff's bases.

    PubMed

    Gupta, Vinod K; Goyal, Rajendra N; Pal, Manoj K; Sharma, Ram A

    2009-10-27

    Praseodymium ion selective polyvinyl chloride (PVC) membrane sensors, based on two new Schiff's bases 1,3-diphenylpropane-1,3-diylidenebis(azan-1-ylidene)diphenol (M(1)) and N,N'-bis(pyridoxylideneiminato) ethylene (M(2)) have been developed and studied. The sensor having membrane composition of PVC: o-NPOE: ionophore (M(1)): NaTPB (w/w; mg) of 150: 300: 8: 5 showed best performances in comparison to M(2) based membranes. The sensor based on (M(1)) exhibits the working concentration range 1.0x10(-8) to 1.0x10(-2) M with a detection limit of 5.0x10(-9) M and a Nernstian slope 20.0+/-0.3 mV decade(-1) of activity. It exhibited a quick response time as <8 s and its potential responses were pH independent across the range of 3.5-8.5. The influence of the membrane composition and possible interfering ions have also been investigated on the response properties of the electrode. The sensor has been found to work satisfactorily in partially non-aqueous media up to 15% (v/v) content of methanol, ethanol or acetonitrile and could be used for a period of 3 months. The selectivity coefficients determined by using fixed interference method (FIM) indicate high selectivity for praseodymium(III) ions over wide variety of other cations. To asses its analytical applicability the prepared sensor was successfully applied for determination of praseodymium(III) in spiked water samples.

  11. A study of LNCFS III coal burners on boiler waterwall tube wastage

    SciTech Connect

    Abbott, R.C.; Gordon, C.M.; Saunders, M.M.; Bray, A.J.

    1996-07-01

    Ultrasonic Testing (UT) of waterwall tubing of a tangentially-fired, sub-critical boiler at Milliken Station of New York State Electric and Gas (NYSEG) was undertaken to determine the effects of the newly installed low NO{sub x} firing system on waterwall tube wastage. During a 1993 outage, the pulverized coal-fired boiler was equipped with an ABB CE Low NO, Concentric Firing System (LNCFS) of the third generation (III) including Staged Overfire Air (SOFA) and a coal pulverizing system capable of improving mill fineness by approximately 30 percent. The study was in conjunction with a Department of Energy Clean Coal Demonstration Project. Three separate thickness, surveys were compared using the Electric Power Research Institute`s (EPRI) Boiler Maintenance Workstation (BMW). The Tube Condition Module of BMW compared a total of 20,556 test locations of the three surveys. The evaluations of the surveys indicate that the short-term effect of low NO{sub x} firing with LNCFS III and increased fineness has moderately reduced the remaining life of the carbon steel boiler tubing in selected locations of the waterfall. Approximately 5 percent of the test locations are experiencing an annual tube wastage of 0.008 inches or greater. Additional testing and analyses are recommended to better understand the longer term effects of the low NO{sub x} firing system and the wastage of selected tubing The influence of boiler operating parameters, such as cyclic duty, proportioning of secondary air, or fuel changes, on waterwall tube wastage should also be evaluated over a longer operating period.

  12. Redox-dependent open and closed forms of the active site of the bacterial respiratory nitric-oxide reductase revealed by cyanide binding studies.

    PubMed

    Grönberg, Karin L C; Watmough, Nicholas J; Thomson, Andrew J; Richardson, David J; Field, Sarah J

    2004-04-23

    The bacterial respiratory nitric-oxide reductase (NOR) catalyzes the respiratory detoxification of nitric oxide in bacteria and Archaea. It is a member of the well known super-family of heme-copper oxidases but has a [heme Fe-non-heme Fe] active site rather than the [heme Fe-Cu(B)] active site normally associated with oxygen reduction. Paracoccus denitrificans NOR is spectrally characterized by a ligand-to-metal charge transfer absorption band at 595 nm, which arises from the high spin ferric heme iron of a micro-oxo-bridged [heme Fe(III)-O-Fe(III)] active site. On reduction of the nonheme iron, the micro-oxo bridge is broken, and the ferric heme iron is hydroxylated or hydrated, depending on the pH. At present, the catalytic cycle of NOR is a matter of much debate, and it is not known to which redox state(s) of the enzyme nitric oxide can bind. This study has used cyanide to probe the nature of the active site in a number of different redox states. Our observations suggest that the micro-oxo-bridged [heme Fe(III)-O-Fe(III)] active site represents a closed or resting state of NOR that can be opened by reduction of the non-heme iron.

  13. Quality Assessment of a Blended Studies Course in the Context of Open Learning Ideas: A Case Study

    ERIC Educational Resources Information Center

    Allan, Audrone; Lukoseviciute-Noreikiene, Ilona

    2008-01-01

    This paper analyses problems of course evaluation in the frame work of open learning. It introduces the process of quality assessment of one specific blended learning course. The centre of research is an individual student. From his perspective, an attempt is being made to look at the course as an opening to new study possibilities. In addition,…

  14. Cyanido-Bridged {Ln(III)W(V)} Heterobinuclear Complexes: Synthesis and Magneto-Structural Study.

    PubMed

    Alexandru, Maria-Gabriela; Visinescu, Diana; Shova, Sergiu; Lloret, Francesc; Julve, Miguel

    2017-09-27

    A new series of cyanido-bridged {Ln(III)W(V)} heterobinuclear complexes of formula [Ln(III)(pyim)2(i-PrOH)(H2O)2(μ-CN)W(V)(CN)7]·2H2O [Ln = Gd (1), Tb (2), Dy (3), Ho (4), and Er (5); pyim = 2-(1H-imidazol-2-yl)-pyridine) and i-PrOH = isopropyl alcohol] were synthesized by one-pot reaction between (NH3Bu)3[W(CN)8] and [Ln(pyim)2](2+) complexes (generated in situ by mixing the corresponding Ln(III) ions and the pyim ligand). Compounds 1-5 are isomorphous and crystallize in the monoclinic system P21/n space group. Their crystal structure consists of binuclear units in which the octacyanotungstate(V) anion coordinates to the corresponding Ln(III) ion through a single cyanide ligand. The tungsten(V) and lanthanide(III) ions are eight-coordinated, in distorted square antiprism (W(V)) and distorted trigonal dodecahedron (Ln(III)) geometries, respectively. The direct-current (dc) magnetic properties for 1-5 reveal the occurrence of weak antiferromagnetic interactions between W(V) and Ln(III) cation, with (8)S7/2, (7)F6, (6)H15/2, (5)I8, and (4)I15/2 as ground terms for Gd(III), Tb(III), Dy(III) Ho(III), and Er(III), respectively [JWLn = -1.19(1) (1), -1.02(2) (2), -1.10(2) (3), -1.30(2) (4), and -1.50(3) cm(-1) (5), the spin Hamiltonian being defined as H = -JWLn SW·SLn]. The fit of the χMT data of 2-4 points out a positive value for the energy gap between the ML components (Δ). This feature is corroborated by their Q-band electron paramagnetic resonance spectra at low temperature, which clearly show MJ = 0 (2 and 4) and ±1/2 (3 and 5). Incipient frequency-dependent alternating-current magnetic susceptibility signals are observed for 3 and 5 under applied dc fields supporting the presence of slow magneti