Pc-Based Floating Point Imaging Workstation

NASA Astrophysics Data System (ADS)

Guzak, Chris J.; Pier, Richard M.; Chinn, Patty; Kim, Yongmin

1989-07-01

The medical, military, scientific and industrial communities have come to rely on imaging and computer graphics for solutions to many types of problems. Systems based on imaging technology are used to acquire and process images, and analyze and extract data from images that would otherwise be of little use. Images can be transformed and enhanced to reveal detail and meaning that would go undetected without imaging techniques. The success of imaging has increased the demand for faster and less expensive imaging systems and as these systems become available, more and more applications are discovered and more demands are made. From the designer's perspective the challenge to meet these demands forces him to attack the problem of imaging from a different perspective. The computing demands of imaging algorithms must be balanced against the desire for affordability and flexibility. Systems must be flexible and easy to use, ready for current applications but at the same time anticipating new, unthought of uses. Here at the University of Washington Image Processing Systems Lab (IPSL) we are focusing our attention on imaging and graphics systems that implement imaging algorithms for use in an interactive environment. We have developed a PC-based imaging workstation with the goal to provide powerful and flexible, floating point processing capabilities, along with graphics functions in an affordable package suitable for diverse environments and many applications.

Intravital imaging of dendritic spine plasticity

PubMed Central

Sau Wan Lai, Cora

2014-01-01

Abstract Dendritic spines are the postsynaptic part of most excitatory synapses in the mammalian brain. Recent works have suggested that the structural and functional plasticity of dendritic spines have been associated with information coding and memories. Advances in imaging and labeling techniques enable the study of dendritic spine dynamics in vivo. This perspective focuses on intravital imaging studies of dendritic spine plasticity in the neocortex. I will introduce imaging tools for studying spine dynamics and will further review current findings on spine structure and function under various physiological and pathological conditions. PMID:28243511

CT myocardial perfusion imaging: current status and future perspectives.

PubMed

Yang, Dong Hyun; Kim, Young-Hak

2017-07-01

Computed tomography myocardial perfusion (CTP) combined with coronary computed tomography angiography (CCTA) may constitute a "1-stop shop" for the noninvasive diagnosis of hemodynamically significant coronary stenosis during a single CT examination. CTP shows high diagnostic performance and provides incremental value over CCTA for the detection of hemodynamically significant coronary stenosis in patients with a high Agatston calcium score or coronary artery stents. Future studies should determine the optimal protocol and clinical value of CTP for guiding revascularization strategy and prognostication. In this article, we review the current status and future perspectives of CTP, focusing on technical considerations, clinical applications, and future research topics.

Left ventricular fluid mechanics: the long way from theoretical models to clinical applications.

PubMed

Pedrizzetti, Gianni; Domenichini, Federico

2015-01-01

The flow inside the left ventricle is characterized by the formation of vortices that smoothly accompany blood from the mitral inlet to the aortic outlet. Computational fluid dynamics permitted to shed some light on the fundamental processes involved with vortex motion. More recently, patient-specific numerical simulations are becoming an increasingly feasible tool that can be integrated with the developing imaging technologies. The existing computational methods are reviewed in the perspective of their potential role as a novel aid for advanced clinical analysis. The current results obtained by simulation methods either alone or in combination with medical imaging are summarized. Open problems are highlighted and perspective clinical applications are discussed.

Computer-Assisted Orthopedic Surgery: Current State and Future Perspective

PubMed Central

Zheng, Guoyan; Nolte, Lutz P.

2015-01-01

Introduced about two decades ago, computer-assisted orthopedic surgery (CAOS) has emerged as a new and independent area, due to the importance of treatment of musculoskeletal diseases in orthopedics and traumatology, increasing availability of different imaging modalities, and advances in analytics and navigation tools. The aim of this paper is to present the basic elements of CAOS devices and to review state-of-the-art examples of different imaging modalities used to create the virtual representations, of different position tracking devices for navigation systems, of different surgical robots, of different methods for registration and referencing, and of CAOS modules that have been realized for different surgical procedures. Future perspectives will also be outlined. PMID:26779486

Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives

PubMed Central

Ngen, Ethel J.; Artemov, Dmitri

2017-01-01

Cell-based therapies are currently being developed for applications in both regenerative medicine and in oncology. Preclinical, translational, and clinical research on cell-based therapies will benefit tremendously from novel imaging approaches that enable the effective monitoring of the delivery, survival, migration, biodistribution, and integration of transplanted cells. Magnetic resonance imaging (MRI) offers several advantages over other imaging modalities for elucidating the fate of transplanted cells both preclinically and clinically. These advantages include the ability to image transplanted cells longitudinally at high spatial resolution without exposure to ionizing radiation, and the possibility to co-register anatomical structures with molecular processes and functional changes. However, since cellular MRI is still in its infancy, it currently faces a number of challenges, which provide avenues for future research and development. In this review, we describe the basic principle of cell-tracking with MRI; explain the different approaches currently used to monitor cell-based therapies; describe currently available MRI contrast generation mechanisms and strategies for monitoring transplanted cells; discuss some of the challenges in tracking transplanted cells; and suggest future research directions. PMID:28106829

Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play

PubMed Central

Savitz, J B; Rauch, S L; Drevets, W C

2013-01-01

In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide treatment selection, the American Psychiatric Association (APA) has recently written a position paper on the Clinical Application of Brain Imaging in Psychiatry. The following perspective piece is based on our contribution to this APA position paper, which specifically emphasized the application of neuroimaging in mood disorders. We present an introductory overview of the challenges faced by researchers in developing valid and reliable biomarkers for psychiatric disorders, followed by a synopsis of the extant neuroimaging findings in mood disorders, and an evidence-based review of the current research on brain imaging biomarkers in adult mood disorders. Although there are a number of promising results, by the standards proposed below, we argue that there are currently no brain imaging biomarkers that are clinically useful for establishing diagnosis or predicting treatment outcome in mood disorders. PMID:23546169

Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play.

PubMed

Savitz, J B; Rauch, S L; Drevets, W C

2013-05-01

In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide treatment selection, the American Psychiatric Association (APA) has recently written a position paper on the Clinical Application of Brain Imaging in Psychiatry. The following perspective piece is based on our contribution to this APA position paper, which specifically emphasized the application of neuroimaging in mood disorders. We present an introductory overview of the challenges faced by researchers in developing valid and reliable biomarkers for psychiatric disorders, followed by a synopsis of the extant neuroimaging findings in mood disorders, and an evidence-based review of the current research on brain imaging biomarkers in adult mood disorders. Although there are a number of promising results, by the standards proposed below, we argue that there are currently no brain imaging biomarkers that are clinically useful for establishing diagnosis or predicting treatment outcome in mood disorders.

"I bet they aren't that perfect in reality:" Appearance ideals viewed from the perspective of adolescents with a positive body image.

PubMed

Holmqvist, Kristina; Frisén, Ann

2012-06-01

In this qualitative study, we examined the topic of appearance ideals from the perspective of 14-year-old adolescents (N=29) with a positive body image. A thematic analysis revealed that the adolescents with a positive body image were very critical against current ideals, describing them as unnatural and unrealistic, and criticizing media for only showing those consistent with the ideals and having underlying intentions with doing so. Instead, the adolescents defined beauty widely and flexibly, stressed the importance of looking like 'oneself', and conveyed the idea of personality as outplaying looks. The perception of beauty as subjective was also prominent. These results may be helpful when forming preventions targeting those at risk for developing negative body image, adding support for preventions based on media literacy and feminist theories. Additionally, we stress the significance of providing adolescents with alternative ways of thinking about ideals, beauty, and attractiveness. Copyright © 2012 Elsevier Ltd. All rights reserved.

Twenty years of terahertz imaging [Invited].

PubMed

Mittleman, Daniel M

2018-04-16

The birth of terahertz imaging approximately coincides with the birth of the journal Optics Express. The 20 th anniversary of the journal is therefore an opportune moment to consider the state of progress in the field of terahertz imaging. This article discusses some of the compelling reasons that one may wish to form images in the THz range, in order to provide a perspective of how far the field has come since the early demonstrations of the mid-1990's. It then focuses on a few of the more prominent frontiers of current research, highlighting their impacts on both fundamental science and applications.

Contrast Media for X-ray and Magnetic Resonance Imaging: Development, Current Status and Future Perspectives.

PubMed

Frenzel, Thomas; Lawaczeck, Rüdiger; Taupitz, Matthias; Jost, Gregor; Lohrke, Jessica; Sieber, Martin A; Pietsch, Hubertus

2015-09-01

Over the last 120 years, the extensive advances in medical imaging allowed enhanced diagnosis and therapy of many diseases and thereby improved the quality of life of many patient generations. From the beginning, all technical solutions and imaging procedures were combined with dedicated pharmaceutical developments of contrast media, to further enhance the visualization of morphology and physiology. This symbiosis of imaging hardware and contrast media development was of high importance for the development of modern clinical radiology. Today, all available clinically approved contrast media fulfill the highest requirements for clinical safety and efficacy. All new concepts to increase the efficacy of contrast media have also to consider the high clinical safety standards and cost of goods of current marketed contrast media. Nevertheless, diagnostic imaging will contribute significantly to the progresses in medicine, and new contrast media developments are mandatory to address the medical needs of the future.

A Kalman Filtering Perspective for Multiatlas Segmentation*

PubMed Central

Gao, Yi; Zhu, Liangjia; Cates, Joshua; MacLeod, Rob S.; Bouix, Sylvain; Tannenbaum, Allen

2016-01-01

In multiatlas segmentation, one typically registers several atlases to the novel image, and their respective segmented label images are transformed and fused to form the final segmentation. In this work, we provide a new dynamical system perspective for multiatlas segmentation, inspired by the following fact: The transformation that aligns the current atlas to the novel image can be not only computed by direct registration but also inferred from the transformation that aligns the previous atlas to the image together with the transformation between the two atlases. This process is similar to the global positioning system on a vehicle, which gets position by inquiring from the satellite and by employing the previous location and velocity—neither answer in isolation being perfect. To solve this problem, a dynamical system scheme is crucial to combine the two pieces of information; for example, a Kalman filtering scheme is used. Accordingly, in this work, a Kalman multiatlas segmentation is proposed to stabilize the global/affine registration step. The contributions of this work are twofold. First, it provides a new dynamical systematic perspective for standard independent multiatlas registrations, and it is solved by Kalman filtering. Second, with very little extra computation, it can be combined with most existing multiatlas segmentation schemes for better registration/segmentation accuracy. PMID:26807162

Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions

PubMed Central

Carroll, Valerie; Demoin, Dustin W.; Hoffman, Timothy J; Jurisson, Silvia S

2013-01-01

Summary Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions. PMID:25382874

Transcranial Direct Current Stimulation of the Temporoparietal Junction and Inferior Frontal Cortex Improves Imitation-Inhibition and Perspective-Taking with no Effect on the Autism-Spectrum Quotient Score.

PubMed

Nobusako, Satoshi; Nishi, Yuki; Nishi, Yuki; Shuto, Takashi; Asano, Daiki; Osumi, Michihiro; Morioka, Shu

2017-01-01

Lesions to brain regions such as the temporoparietal junction (TPJ) and inferior frontal cortex (IFC) are thought to cause autism-spectrum disorder (ASD). Previous studies indicated that transcranial direct current stimulation (tDCS) of the right TPJ improves social cognitive functions such as imitation-inhibition and perspective-taking. Although previous work shows that tDCS of the right IFC improves imitation-inhibition, its effects on perspective-taking have yet to be determined. In addition, the role of the TPJ and IFC in determining the Autism-Spectrum Quotient (AQ), which is a measure of autism spectrum traits, is still unclear. Thus, the current study performed tDCS on the right TPJ and the right IFC of healthy adults, and examined its effects on imitation-inhibition, perspective-taking and AQ scores. Based on previous studies, we hypothesized that anodal tDCS of the right IFC and right TPJ would improve imitation-inhibition, perspective-taking and the AQ score. Anodal tDCS of the right TPJ or IFC significantly decreased the interference effect in an imitation-inhibition task and the cost of perspective-taking in a perspective-taking task, in comparison to the sham stimulation control. These findings indicated that both the TPJ and the IFC play a role in imitation-inhibition and perspective-taking, i.e., control of self and other representations. However, anodal stimulation of the right TPJ and the right IFC did not alter participants' AQ. This finding conflicts with results from previous brain imaging studies, which could be attributed to methodological differences such as variation in sex, age and ASD. Therefore, further research is necessary to determine the relationship between the TPJ and IFC, and the AQ.

Transcranial Direct Current Stimulation of the Temporoparietal Junction and Inferior Frontal Cortex Improves Imitation-Inhibition and Perspective-Taking with no Effect on the Autism-Spectrum Quotient Score

PubMed Central

Nobusako, Satoshi; Nishi, Yuki; Nishi, Yuki; Shuto, Takashi; Asano, Daiki; Osumi, Michihiro; Morioka, Shu

2017-01-01

Lesions to brain regions such as the temporoparietal junction (TPJ) and inferior frontal cortex (IFC) are thought to cause autism-spectrum disorder (ASD). Previous studies indicated that transcranial direct current stimulation (tDCS) of the right TPJ improves social cognitive functions such as imitation-inhibition and perspective-taking. Although previous work shows that tDCS of the right IFC improves imitation-inhibition, its effects on perspective-taking have yet to be determined. In addition, the role of the TPJ and IFC in determining the Autism-Spectrum Quotient (AQ), which is a measure of autism spectrum traits, is still unclear. Thus, the current study performed tDCS on the right TPJ and the right IFC of healthy adults, and examined its effects on imitation-inhibition, perspective-taking and AQ scores. Based on previous studies, we hypothesized that anodal tDCS of the right IFC and right TPJ would improve imitation-inhibition, perspective-taking and the AQ score. Anodal tDCS of the right TPJ or IFC significantly decreased the interference effect in an imitation-inhibition task and the cost of perspective-taking in a perspective-taking task, in comparison to the sham stimulation control. These findings indicated that both the TPJ and the IFC play a role in imitation-inhibition and perspective-taking, i.e., control of self and other representations. However, anodal stimulation of the right TPJ and the right IFC did not alter participants’ AQ. This finding conflicts with results from previous brain imaging studies, which could be attributed to methodological differences such as variation in sex, age and ASD. Therefore, further research is necessary to determine the relationship between the TPJ and IFC, and the AQ. PMID:28536512

Images of Schools: Structures and Roles in Organizational Behavior.

ERIC Educational Resources Information Center

Bacharach, Samuel B., Ed.; Mundell, Bryan, Ed.

This book brings together different analytical perspectives from organizational theory and applies them to examinations of schools. The editors maintain that the current debate over school restructuring is essentially a debate over which strategy of organizing will achieve the best results. Organizational theory suggests that there are two primary…

Through Family Eyes: Towards a More Adequate Perspective for Viewing Native American Religious Life.

ERIC Educational Resources Information Center

Swanson, Tod D.

1997-01-01

Examines strategies used by non-Native scholars who write or teach about American-Indian religious traditions. The current trend--an apologetic stance emphasizing contrasting "representative" Native and European voices--unwittingly reinforces stereotypes and appropriation of idealized Native images. In contrast, approaching the subject…

Clinical review: Lung imaging in acute respiratory distress syndrome patients - an update

PubMed Central

2013-01-01

Over the past 30 years lung imaging has greatly contributed to the current understanding of the pathophysiology and the management of acute respiratory distress syndrome (ARDS). In the past few years, in addition to chest X-ray and lung computed tomography, newer functional lung imaging techniques, such as lung ultrasound, positron emission tomography, electrical impedance tomography and magnetic resonance, have been gaining a role as diagnostic tools to optimize lung assessment and ventilator management in ARDS patients. Here we provide an updated clinical review of lung imaging in ARDS over the past few years to offer an overview of the literature on the available imaging techniques from a clinical perspective. PMID:24238477

Utilization management in radiology, part 2: perspectives and future directions.

PubMed

Duszak, Richard; Berlin, Jonathan W

2012-10-01

Increased utilization of medical imaging in the early part of the last decade has resulted in numerous efforts to reduce associated spending. Recent initiatives have focused on managing utilization with radiology benefits managers and real-time order entry decision support systems. Although these approaches might seem mutually exclusive and their application to radiology appears unique, the historical convergence and broad acceptance of both programs within the pharmacy sector may offer parallels for their potential future in medical imaging. In this second installment of a two-part series, anticipated trends in radiology utilization management are reviewed. Perspectives on current and future potential roles of radiologists in such initiatives are discussed, particularly in light of emerging physician payment models. Copyright © 2012 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Imaging techniques in the management of chronic kidney disease: current developments and future perspectives.

PubMed

Herget-Rosenthal, Stefan

2011-05-01

The measurement of both renal function and structure is critical in clinical nephrology to detect, stage, and monitor chronic kidney disease (CKD). Current imaging modalities especially ultrasound (US), computed tomography, and magnetic resonance imaging (MRI) provide adequate information on structural changes but little on functional impairment in CKD. Although not yet considered first-line procedures for evaluating patients with renal disease, new US and MR imaging techniques may permit the assessment of renal function in the near future. Combined with established imaging techniques, contrast-enhanced US, dynamic contrast-enhanced MRI, blood oxygen level dependency MRI, or diffusion-weighted imaging may provide rapid, accurate, simultaneous, and noninvasive imaging of the structure of kidneys, macrovascular and microvascular renal perfusion, oxygenation, and glomerular filtration rate. Recent developments in molecular imaging indicate that pathophysiological pathways of renal diseases such as apoptosis, coagulation, fibrosis, and ischemia will be visualized at the tissue level. These major advances in imaging and developments in hardware and software could enable comprehensive imaging of renal structure and function in four dimensions (three dimensions plus time), and imaging is expected to play an increasing role in the management of CKD. Copyright © 2011 Elsevier Inc. All rights reserved.

Concepts for a geostationary-like polar mission

NASA Astrophysics Data System (ADS)

Macdonald, Malcolm; Anderson, Pamela; Carrea, Laura; Dobke, Benjamin; Embury, Owen; Merchant, Chris; Bensi, Paolo

2014-10-01

An evidence-led scientific case for development of a space-based polar remote sensing platform at geostationary-like (GEO-like) altitudes is developed through methods including a data user survey. Whilst a GEO platform provides a nearstatic perspective, multiple platforms are required to provide circumferential coverage. Systems for achieving GEO-like polar observation likewise require multiple platforms however the perspective is non-stationery. A key choice is between designs that provide complete polar view from a single platform at any given instant, and designs where this is obtained by compositing partial views from multiple sensors. Users foresee an increased challenge in extracting geophysical information from composite images and consider the use of non-composited images advantageous. Users also find the placement of apogee over the pole to be preferable to the alternative scenarios. Thus, a clear majority of data users find the "Taranis" orbit concept to be better than a critical inclination orbit, due to the improved perspective offered. The geophysical products that would benefit from a GEO-like polar platform are mainly estimated from radiances in the visible/near infrared and thermal parts of the electromagnetic spectrum, which is consistent with currently proven technologies from GEO. Based on the survey results, needs analysis, and current technology proven from GEO, scientific and observation requirements are developed along with two instrument concepts with eight and four channels, based on Flexible Combined Imager heritage. It is found that an operational system could, mostly likely, be deployed from an Ariane 5 ES to a 16-hour orbit, while a proof-of-concept system could be deployed from a Soyuz launch to the same orbit.

Tomographic image reconstruction using the cell broadband engine (CBE) general purpose hardware

NASA Astrophysics Data System (ADS)

Knaup, Michael; Steckmann, Sven; Bockenbach, Olivier; Kachelrieß, Marc

2007-02-01

Tomographic image reconstruction, such as the reconstruction of CT projection values, of tomosynthesis data, PET or SPECT events, is computational very demanding. In filtered backprojection as well as in iterative reconstruction schemes, the most time-consuming steps are forward- and backprojection which are often limited by the memory bandwidth. Recently, a novel general purpose architecture optimized for distributed computing became available: the Cell Broadband Engine (CBE). Its eight synergistic processing elements (SPEs) currently allow for a theoretical performance of 192 GFlops (3 GHz, 8 units, 4 floats per vector, 2 instructions, multiply and add, per clock). To maximize image reconstruction speed we modified our parallel-beam and perspective backprojection algorithms which are highly optimized for standard PCs, and optimized the code for the CBE processor. 1-3 In addition, we implemented an optimized perspective forwardprojection on the CBE which allows us to perform statistical image reconstructions like the ordered subset convex (OSC) algorithm. 4 Performance was measured using simulated data with 512 projections per rotation and 5122 detector elements. The data were backprojected into an image of 512 3 voxels using our PC-based approaches and the new CBE- based algorithms. Both the PC and the CBE timings were scaled to a 3 GHz clock frequency. On the CBE, we obtain total reconstruction times of 4.04 s for the parallel backprojection, 13.6 s for the perspective backprojection and 192 s for a complete OSC reconstruction, consisting of one initial Feldkamp reconstruction, followed by 4 OSC iterations.

Toward microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective

NASA Astrophysics Data System (ADS)

Klimas, Aleksandra; Entcheva, Emilia

2014-08-01

The ability to perform precise, spatially localized actuation and measurements of electrical activity in the heart is crucial in understanding cardiac electrophysiology and devising new therapeutic solutions for control of cardiac arrhythmias. Current cardiac imaging techniques (i.e. optical mapping) employ voltage- or calcium-sensitive fluorescent dyes to visualize the electrical signal propagation through cardiac syncytium in vitro or in situ with very high-spatiotemporal resolution. The extension of optogenetics into the cardiac field, where cardiac tissue is genetically altered to express light-sensitive ion channels allowing electrical activity to be elicited or suppressed in a precise cell-specific way, has opened the possibility for all-optical interrogation of cardiac electrophysiology. In vivo application of cardiac optogenetics faces multiple challenges and necessitates suitable optical systems employing fiber optics to actuate and sense electrical signals. In this technical perspective, we present a compendium of clinically relevant access routes to different parts of the cardiac electrical conduction system based on currently employed catheter imaging systems and determine the quantitative size constraints for endoscopic cardiac optogenetics. We discuss the relevant technical advancements in microendoscopy, cardiac imaging, and optogenetics and outline the strategies for combining them to create a portable, miniaturized fiber-based system for all-optical interrogation of cardiac electrophysiology in vivo.

Urban Forests and Carbon Markets: Buyers’ Perspectives

Treesearch

Neelam C. Poudyal; Jacek Siry; J.M. Bowker

2011-01-01

Currently, carbon credit prices frequently do not reflect the type and location of offset projects. Because of the social image and ancillary benefits, buyers may place higher value on credits sourced from certain types of projects such as urban forestry. This study surveyed carbon credit buyers participating in the Chicago Climate Exchange to assess their preferences...

Tissue Doppler and strain imaging: anything left in the echo-lab?

PubMed Central

Citro, Rodolfo; Bossone, Eduardo; Kuersten, Bettina; Gregorio, Giovanni; Salustri, Alessandro

2008-01-01

Medline research indicates that an increasing number of manuscripts have been published in the last decade claiming, the feasibility and the potential clinical role of tissue Doppler and strain/strain rate imaging. However, despite this amount of scientific evidence, these technologies are still confined to dedicated, high-tech, research-oriented echocardiography laboratories. In this review we have critically evaluated these techniques, analysing their physical principles, the technical problems related to their current clinical application, and the future perspectives. Finally, this review explores the reasons why these technologies are still defined "new technologies" and the impact of their implementation on the current clinical activity of an echocardiography laboratory. PMID:18973677

Anterior Segment Imaging for Angle Closure.

PubMed

Chansangpetch, Sunee; Rojanapongpun, Prin; Lin, Shan C

2018-04-01

To summarize the role of anterior segment imaging (AS-imaging) in angle closure diagnosis and management, and the possible advantages over the current standard of gonioscopy. Literature review and perspective. Review of the pertinent publications with interpretation and perspective in relation to the use of AS-imaging in angle closure assessment focusing on anterior segment optical coherence tomography and ultrasound biomicroscopy. Several limitations have been encountered with the reference standard of gonioscopy for angle assessment. AS-imaging has been shown to have performance in angle closure detection compared to gonioscopy. Also, imaging has greater reproducibility and serves as better documentation for long-term follow-up than conventional gonioscopy. The qualitative and quantitative information obtained from AS-imaging enables better understanding of the underlying mechanisms of angle closure and provides useful parameters for risk assessment and possible prediction of the response to laser and surgical intervention. The latest technologies-including 3-dimensional imaging-have allowed for the assessment of the angle that simulates the gonioscopic view. These advantages suggest that AS-imaging has a potential to be a reference standard for the diagnosis and monitoring of angle closure disease in the future. Although gonioscopy remains the primary method of angle assessment, AS-imaging has an increasing role in angle closure screening and management. The test should be integrated into clinical practice as an adjunctive tool for angle assessment. It is arguable that AS-imaging should be considered first-line screening for patients at risk for angle closure. Copyright © 2018 Elsevier Inc. All rights reserved.

Three-dimensional head anthropometric analysis

NASA Astrophysics Data System (ADS)

Enciso, Reyes; Shaw, Alex M.; Neumann, Ulrich; Mah, James

2003-05-01

Currently, two-dimensional photographs are most commonly used to facilitate visualization, assessment and treatment of facial abnormalities in craniofacial care but are subject to errors because of perspective, projection, lack metric and 3-dimensional information. One can find in the literature a variety of methods to generate 3-dimensional facial images such as laser scans, stereo-photogrammetry, infrared imaging and even CT however each of these methods contain inherent limitations and as such no systems are in common clinical use. In this paper we will focus on development of indirect 3-dimensional landmark location and measurement of facial soft-tissue with light-based techniques. In this paper we will statistically evaluate and validate a current three-dimensional image-based face modeling technique using a plaster head model. We will also develop computer graphics tools for indirect anthropometric measurements in a three-dimensional head model (or polygonal mesh) including linear distances currently used in anthropometry. The measurements will be tested against a validated 3-dimensional digitizer (MicroScribe 3DX).

Looking back in time: self-concept change affects visual perspective in autobiographical memory.

PubMed

Libby, Lisa K; Eibach, Richard P

2002-02-01

People who change often report that their old selves seem like "different people." Correlational (Study 1) and experimental (Studies 2 and 3) studies showed that participants tended to use a 3rd-person observer perspective when visualizing memories of actions that conflicted with their current self-concept. A similar pattern emerged when participants imagined performing actions that varied in self-concept compatibility (Study 4). The authors conclude that on-line judgments of an action's self-concept compatibility affect the perspective used for image construction. Study 5 shows applied implications. Use of the 3rd-person perspective when recalling past episodes of overindulgent eating was related to optimism about behaving differently at an upcoming Thanksgiving dinner. The authors discuss the effect of self-concept compatibility on cognitive and emotional reactions to past actions and consider the role of causal attributions in defining the self across time.

Broad perspectives in radar for ocean measurements

NASA Technical Reports Server (NTRS)

Jain, A.

1978-01-01

The various active radar implementation options available for the measurement functions of interest for the SEASAT follow-on missions were evaluated. These functions include surface feature imaging, surface pressure and vertical profile, atmospheric sounding, surface backscatter and wind speed determination, surface current location, wavelength spectra, sea surface topography, and ice/snow thickness. Some concepts for the Synthetic Aperture Imaging Radar were examined that may be useful in the design and selection of the implementation options for these missions. The applicability of these instruments for the VOIR mission was also kept under consideration.

Ultrasonic image analysis and image-guided interventions.

PubMed

Noble, J Alison; Navab, Nassir; Becher, H

2011-08-06

The fields of medical image analysis and computer-aided interventions deal with reducing the large volume of digital images (X-ray, computed tomography, magnetic resonance imaging (MRI), positron emission tomography and ultrasound (US)) to more meaningful clinical information using software algorithms. US is a core imaging modality employed in these areas, both in its own right and used in conjunction with the other imaging modalities. It is receiving increased interest owing to the recent introduction of three-dimensional US, significant improvements in US image quality, and better understanding of how to design algorithms which exploit the unique strengths and properties of this real-time imaging modality. This article reviews the current state of art in US image analysis and its application in image-guided interventions. The article concludes by giving a perspective from clinical cardiology which is one of the most advanced areas of clinical application of US image analysis and describing some probable future trends in this important area of ultrasonic imaging research.

Harnessing the potential of noninvasive in vivo preclinical imaging of the immune system: challenges and prospects.

PubMed

Diken, Mustafa; Pektor, Stefanie; Miederer, Matthias

2016-10-01

Preclinical imaging has become a powerful method for investigation of in vivo processes such as pharmacokinetics of therapeutic substances and visualization of physiologic and pathophysiological mechanisms. These are important aspects to understand diseases and develop strategies to modify their progression with pharmacologic interventions. One promising intervention is the application of specifically tailored nanoscale particles that modulate the immune system to generate a tumor targeting immune response. In this complex interaction between immunomodulatory therapies, the immune system and malignant disease, imaging methods are expected to play a key role on the way to generate new therapeutic strategies. Here, we summarize examples which demonstrate the current potential of imaging methods and develop a perspective on the future value of preclinical imaging of the immune system.

SU-E-J-134: An Augmented-Reality Optical Imaging System for Accurate Breast Positioning During Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nazareth, D; Malhotra, H; French, S

Purpose: Breast radiotherapy, particularly electronic compensation, may involve large dose gradients and difficult patient positioning problems. We have developed a simple self-calibrating augmented-reality system, which assists in accurately and reproducibly positioning the patient, by displaying her live image from a single camera superimposed on the correct perspective projection of her 3D CT data. Our method requires only a standard digital camera capable of live-view mode, installed in the treatment suite at an approximately-known orientation and position (rotation R; translation T). Methods: A 10-sphere calibration jig was constructed and CT imaged to provide a 3D model. The (R,T) relating the cameramore » to the CT coordinate system were determined by acquiring a photograph of the jig and optimizing an objective function, which compares the true image points to points calculated with a given candidate R and T geometry. Using this geometric information, 3D CT patient data, viewed from the camera's perspective, is plotted using a Matlab routine. This image data is superimposed onto the real-time patient image, acquired by the camera, and displayed using standard live-view software. This enables the therapists to view both the patient's current and desired positions, and guide the patient into assuming the correct position. The method was evaluated using an in-house developed bolus-like breast phantom, mounted on a supporting platform, which could be tilted at various angles to simulate treatment-like geometries. Results: Our system allowed breast phantom alignment, with an accuracy of about 0.5 cm and 1 ± 0.5 degree. Better resolution could be possible using a camera with higher-zoom capabilities. Conclusion: We have developed an augmented-reality system, which combines a perspective projection of a CT image with a patient's real-time optical image. This system has the potential to improve patient setup accuracy during breast radiotherapy, and could possibly be used for other disease sites as well.« less

Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives.

PubMed

Backhaus, Philipp; Noto, Benjamin; Avramovic, Nemanja; Grubert, Lena Sophie; Huss, Sebastian; Bögemann, Martin; Stegger, Lars; Weckesser, Matthias; Schäfers, Michael; Rahbar, Kambiz

2018-05-01

Prostate-specific membrane antigen (PSMA) is the up-and-coming target for molecular imaging of prostate cancer. Despite its name, non-prostate-related PSMA expression in physiologic tissue as well as in benign and malignant disease has been reported in various publications. Unlike in prostate cancer, PSMA expression is only rarely observed in non-prostate tumor cells. Instead, expression occurs in endothelial cells of tumor-associated neovasculature, although no endothelial expression is observed under physiologic conditions. The resulting potential for tumor staging in non-prostate malignant tumors has been demonstrated in first patient studies. This review summarizes the first clinical studies and deduces future perspectives in staging, molecular characterization, and PSMA-targeted radionuclide therapy based on histopathologic examinations of PSMA expression. The non-exclusivity of PSMA in prostate cancer opens a window to utilize the spectrum of available radioactive PSMA ligands for imaging and molecular characterization and maybe even therapy of non-prostate disease.

Radioactive Nanomaterials for Multimodality Imaging

PubMed Central

Chen, Daiqin; Dougherty, Casey A.; Yang, Dongzhi; Wu, Hongwei; Hong, Hao

2016-01-01

Nuclear imaging techniques, including primarily positron emission tomography (PET) and single-photon emission computed tomography (SPECT), can provide quantitative information for a biological event in vivo with ultra-high sensitivity, however, the comparatively low spatial resolution is their major limitation in clinical application. By convergence of nuclear imaging with other imaging modalities like computed tomography (CT), magnetic resonance imaging (MRI) and optical imaging, the hybrid imaging platforms can overcome the limitations from each individual imaging technique. Possessing versatile chemical linking ability and good cargo-loading capacity, radioactive nanomaterials can serve as ideal imaging contrast agents. In this review, we provide a brief overview about current state-of-the-art applications of radioactive nanomaterials in the circumstances of multimodality imaging. We present strategies for incorporation of radioisotope(s) into nanomaterials along with applications of radioactive nanomaterials in multimodal imaging. Advantages and limitations of radioactive nanomaterials for multimodal imaging applications are discussed. Finally, a future perspective of possible radioactive nanomaterial utilization is presented for improving diagnosis and patient management in a variety of diseases. PMID:27227167

Role of PET/CT for precision medicine in lung cancer: perspective of the Society of Nuclear Medicine and Molecular Imaging.

PubMed

Greenspan, Bennett S

2017-12-01

This article discusses the role of PET/CT in contributing to precision medicine in lung cancer, and provides the perspective of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) on this process. The mission and vision of SNMMI are listed, along with the guidance provided by SNMMI to promote best practice in precision medicine. Basic principles of PET/CT are presented. An overview of the use of PET/CT imaging in lung cancer is discussed. In lung cancer patients, PET/CT is vitally important for optimal patient management. PET/CT is essential in determining staging and re-staging of disease, detecting recurrent or residual disease, evaluating response to therapy, and providing prognostic information. PET/CT is also critically important in radiation therapy planning by determining the extent of active disease, including an assessment of functional tumor volume. The current approach in tumor imaging is a significant advance over conventional imaging. However, recent advances suggest that therapeutic response criteria in the near future will be based on metabolic characteristics and will include the evaluation of biologic characteristics of tumors to further enhance the effectiveness of precision medicine in lung cancer, producing improved patient outcomes with less morbidity.

Conical Perspective Image of an Architectural Object Close to Human Perception

NASA Astrophysics Data System (ADS)

Dzwierzynska, Jolanta

2017-10-01

The aim of the study is to develop a method of computer aided constructing conical perspective of an architectural object, which is close to human perception. The conical perspective considered in the paper is a central projection onto a projection surface being a conical rotary surface or a fragment of it. Whereas, the centre of projection is a stationary point or a point moving on a circular path. The graphical mapping results of the perspective representation is realized directly on an unrolled flat projection surface. The projective relation between a range of points on a line and the perspective image of the same range of points received on a cylindrical projection surface permitted to derive formulas for drawing perspective. Next, the analytical algorithms for drawing perspective image of a straight line passing through any two points were formulated. It enabled drawing a perspective wireframe image of a given 3D object. The use of the moving view point as well as the application of the changeable base elements of perspective as the variables in the algorithms enable drawing conical perspective from different viewing positions. Due to this fact, the perspective drawing method is universal. The algorithms are formulated and tested in Mathcad Professional software, but can be implemented in AutoCAD and majority of computer graphical packages, which makes drawing a perspective image more efficient and easier. The presented conical perspective representation, and the convenient method of its mapping directly on the flat unrolled surface can find application for numerous advertisement and art presentations.

Surveillance imaging for lymphoma: pros and cons.

PubMed

Lynch, Ryan C; Zelenetz, Andrew D; Armitage, James O; Carson, Kenneth R

2014-01-01

There is no international consensus on the optimal frequency or duration of computed tomography or positron emission tomography scanning for surveillance in patients who achieve complete remission after initial therapy for lymphoma. Although some clinical practice guidelines suggest periodic imaging is reasonable, others suggest little or no benefit to this practice. From a theoretical perspective, the frequency and duration of surveillance imaging is largely dependent upon the lymphoma subtype. Aggressive lymphomas with a fast growth rate will require surveillance more frequently and for a shorter duration compared to the indolent lymphomas. Historically, relapse has been detected in a majority of patients based upon clinically evident signs and symptoms. Currently, no study has demonstrated an overall survival difference for patients with relapse detected by imaging as opposed to clinical evaluation, although one study did demonstrate a lower second-line International Prognostic Index in patients with relapse detected by surveillance imaging. Enthusiasm for this finding has been tempered by recent studies highlighting the potential long-term risk of secondary malignancies because of ionizing radiation exposure from diagnostic imaging. These factors along with the significant costs associated with diagnostic imaging have contributed to an ongoing debate regarding the relative costs, risks, and benefits of radiographic surveillance. Herein we present perspectives for and against routine surveillance imaging in an effort to facilitate a better understanding of the issues relevant to what is ultimately a clinical decision made by an oncologist and his or her patient.

A Multi-Dimensional Approach to Gradient Change in Phonological Acquisition: A Case Study of Disordered Speech Development

ERIC Educational Resources Information Center

Glaspey, Amy M.; MacLeod, Andrea A. N.

2010-01-01

The purpose of the current study is to document phonological change from a multidimensional perspective for a 3-year-old boy with phonological disorder by comparing three measures: (1) accuracy of consonant productions, (2) dynamic assessment, and (3) acoustic analysis. The methods included collecting a sample of the targets /s, [image omitted],…

A forensic science perspective on the role of images in crime investigation and reconstruction.

PubMed

Milliet, Quentin; Delémont, Olivier; Margot, Pierre

2014-12-01

This article presents a global vision of images in forensic science. The proliferation of perspectives on the use of images throughout criminal investigations and the increasing demand for research on this topic seem to demand a forensic science-based analysis. In this study, the definitions of and concepts related to material traces are revisited and applied to images, and a structured approach is used to persuade the scientific community to extend and improve the use of images as traces in criminal investigations. Current research efforts focus on technical issues and evidence assessment. This article provides a sound foundation for rationalising and explaining the processes involved in the production of clues from trace images. For example, the mechanisms through which these visual traces become clues of presence or action are described. An extensive literature review of forensic image analysis emphasises the existing guidelines and knowledge available for answering investigative questions (who, what, where, when and how). However, complementary developments are still necessary to demystify many aspects of image analysis in forensic science, including how to review and select images or use them to reconstruct an event or assist intelligence efforts. The hypothetico-deductive reasoning pathway used to discover unknown elements of an event or crime can also help scientists understand the underlying processes involved in their decision making. An analysis of a single image in an investigative or probative context is used to demonstrate the highly informative potential of images as traces and/or clues. Research efforts should be directed toward formalising the extraction and combination of clues from images. An appropriate methodology is key to expanding the use of images in forensic science. Copyright © 2014 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.

Magnetic resonance spectroscopic imaging at superresolution: Overview and perspectives

NASA Astrophysics Data System (ADS)

Kasten, Jeffrey; Klauser, Antoine; Lazeyras, François; Van De Ville, Dimitri

2016-02-01

The notion of non-invasive, high-resolution spatial mapping of metabolite concentrations has long enticed the medical community. While magnetic resonance spectroscopic imaging (MRSI) is capable of achieving the requisite spatio-spectral localization, it has traditionally been encumbered by significant resolution constraints that have thus far undermined its clinical utility. To surpass these obstacles, research efforts have primarily focused on hardware enhancements or the development of accelerated acquisition strategies to improve the experimental sensitivity per unit time. Concomitantly, a number of innovative reconstruction techniques have emerged as alternatives to the standard inverse discrete Fourier transform (DFT). While perhaps lesser known, these latter methods strive to effect commensurate resolution gains by exploiting known properties of the underlying MRSI signal in concert with advanced image and signal processing techniques. This review article aims to aggregate and provide an overview of the past few decades of so-called "superresolution" MRSI reconstruction methodologies, and to introduce readers to current state-of-the-art approaches. A number of perspectives are then offered as to the future of high-resolution MRSI, with a particular focus on translation into clinical settings.

Geometric, Kinematic and Radiometric Aspects of Image-Based Measurements

NASA Technical Reports Server (NTRS)

Liu, Tianshu

2002-01-01

This paper discusses theoretical foundations of quantitative image-based measurements for extracting and reconstructing geometric, kinematic and dynamic properties of observed objects. New results are obtained by using a combination of methods in perspective geometry, differential geometry. radiometry, kinematics and dynamics. Specific topics include perspective projection transformation. perspective developable conical surface, perspective projection under surface constraint, perspective invariants, the point correspondence problem. motion fields of curves and surfaces. and motion equations of image intensity. The methods given in this paper arc useful for determining morphology and motion fields of deformable bodies such as elastic bodies. viscoelastic mediums and fluids.

HOPIS: hybrid omnidirectional and perspective imaging system for mobile robots.

PubMed

Lin, Huei-Yung; Wang, Min-Liang

2014-09-04

In this paper, we present a framework for the hybrid omnidirectional and perspective robot vision system. Based on the hybrid imaging geometry, a generalized stereo approach is developed via the construction of virtual cameras. It is then used to rectify the hybrid image pair using the perspective projection model. The proposed method not only simplifies the computation of epipolar geometry for the hybrid imaging system, but also facilitates the stereo matching between the heterogeneous image formation. Experimental results for both the synthetic data and real scene images have demonstrated the feasibility of our approach.

HOPIS: Hybrid Omnidirectional and Perspective Imaging System for Mobile Robots

PubMed Central

Lin, Huei-Yung.; Wang, Min-Liang.

2014-01-01

In this paper, we present a framework for the hybrid omnidirectional and perspective robot vision system. Based on the hybrid imaging geometry, a generalized stereo approach is developed via the construction of virtual cameras. It is then used to rectify the hybrid image pair using the perspective projection model. The proposed method not only simplifies the computation of epipolar geometry for the hybrid imaging system, but also facilitates the stereo matching between the heterogeneous image formation. Experimental results for both the synthetic data and real scene images have demonstrated the feasibility of our approach. PMID:25192317

Terahertz endoscopic imaging for colorectal cancer detection: Current status and future perspectives

PubMed Central

Doradla, Pallavi; Joseph, Cecil; Giles, Robert H

2017-01-01

Terahertz (THz) imaging is progressing as a robust platform for myriad applications in the field of security, health, and material science. The THz regime, which comprises wavelengths spanning from microns to millimeters, is non-ionizing and has very low photon energy: Making it inherently safe for biological imaging. Colorectal cancer is one of the most common causes of death in the world, while the conventional screening and standard of care yet relies exclusively on the physician’s experience. Researchers have been working on the development of a flexible THz endoscope, as a potential tool to aid in colorectal cancer screening. This involves building a single-channel THz endoscope, and profiling the THz response from colorectal tissue, and demonstrating endogenous contrast levels between normal and diseased tissue when imaging in reflection modality. The current level of contrast provided by the prototype THz endoscopic system represents a significant step towards clinical endoscopic application of THz technology for in-vivo colorectal cancer screening. The aim of this paper is to provide a short review of the recent advances in THz endoscopic technology and cancer imaging. In particular, the potential of single-channel THz endoscopic imaging for colonic cancer screening will be highlighted. PMID:28874955

Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach

PubMed Central

Cho, In K; Wang, Silun; Mao, Hui; Chan, Anthony WS

2016-01-01

Recent advances in stem cell-based regenerative medicine, cell replacement therapy, and genome editing technologies (i.e. CRISPR-Cas 9) have sparked great interest in in vivo cell monitoring. Molecular imaging promises a unique approach to noninvasively monitor cellular and molecular phenomena, including cell survival, migration, proliferation, and even differentiation at the whole organismal level. Several imaging modalities and strategies have been explored for monitoring cell grafts in vivo. We begin this review with an introduction describing the progress in stem cell technology, with a perspective toward cell replacement therapy. The importance of molecular imaging in reporting and assessing the status of cell grafts and their relation to the local microenvironment is highlighted since the current knowledge gap is one of the major obstacles in clinical translation of stem cell therapy. Based on currently available imaging techniques, we provide a brief discussion on the pros and cons of each imaging modality used for monitoring cell grafts with particular emphasis on magnetic resonance imaging (MRI) and the reporter gene approach. Finally, we conclude with a comprehensive discussion of future directions of applying molecular imaging in regenerative medicine to emphasize further the importance of correlating cell graft conditions and clinical outcomes to advance regenerative medicine. PMID:27766183

Use of ultrasmall superparamagnetic iron oxide particles for imaging carotid atherosclerosis.

PubMed

Usman, Ammara; Sadat, Umar; Patterson, Andrew J; Tang, Tjun Y; Varty, Kevin; Boyle, Jonathan R; Armon, Mathew P; Hayes, Paul D; Graves, Martin J; Gillard, Jonathan H

2015-10-01

Based on the results of histopathological studies, inflammation within atherosclerotic tissue is now widely accepted as a key determinant of the disease process. Conventional imaging methods can highlight the location and degree of luminal stenosis but not the inflammatory activity of the plaque. Iron oxide-based MRI contrast media particularly ultrasmall supermagnetic particles of iron oxide have shown potential in assessing atheromatous plaque inflammation and in determining efficacy of antiatherosclerosis pharmacological treatments. In this paper, we review current data on the use of ultrasmall superparamagnetic iron oxides in atherosclerosis imaging with focus on ferumoxtran-10 and ferumoxytol. The basic chemistry, pharmacokinetics and dynamics, potential applications, limitations and future perspectives of these contrast media nanoparticles are discussed.

Nonmetastatic Castration-resistant Prostate Cancer: A Modern Perspective.

PubMed

Cancian, Madeline; Renzulli, Joseph F

2018-06-01

Nonmetastatic castration-resistant prostate cancer (nmCRPC) presents a challenge to urologists as currently there are no Food and Drug Administration-approved therapies. However, there are new imaging modalities, including fluciclovine positron emission tomography-computed tomography and Ga-PSMA (prostate specific membrane antigent) positron emission tomography-computed tomography, which are improving accuracy of diagnosis. With improved imaging, we are better able to target therapy. Today there are 3 ongoing clinical trials studying second-generation antiandrogens in nmCRPC, which hold the promise of a new treatment paradigm. In this article, we will review the new imaging techniques and the rationale behind novel treatment modalities in nmCRPC. Copyright © 2018 Elsevier Inc. All rights reserved.

Recreation of three-dimensional objects in a real-time simulated environment by means of a panoramic single lens stereoscopic image-capturing device

NASA Astrophysics Data System (ADS)

Wong, Erwin

2000-03-01

Traditional methods of linear based imaging limits the viewer to a single fixed-point perspective. By means of a single lens multiple perspective mirror system, a 360-degree representation of the area around the camera is reconstructed. This reconstruction is used overcome the limitations of a traditional camera by providing the viewer with many different perspectives. By constructing the mirror into a hemispherical surface with multiple focal lengths at various diameters on the mirror, and by placing a parabolic mirror overhead, a stereoscopic image can be extracted from the image captured by a high-resolution camera placed beneath the mirror. Image extraction and correction is made by computer processing of the image obtained by camera; the image present up to five distinguishable different viewpoints that a computer can extrapolate pseudo- perspective data from. Geometric and depth for field can be extrapolated via comparison and isolation of objects within a virtual scene post processed by the computer. Combining data with scene rendering software provides the viewer with the ability to choose a desired viewing position, multiple dynamic perspectives, and virtually constructed perspectives based on minimal existing data. An examination into the workings of the mirror relay system is provided, including possible image extrapolation and correctional methods. Generation of data and virtual interpolated and constructed data is also mentioned.

Geometric rectification of camera-captured document images.

PubMed

Liang, Jian; DeMenthon, Daniel; Doermann, David

2008-04-01

Compared to typical scanners, handheld cameras offer convenient, flexible, portable, and non-contact image capture, which enables many new applications and breathes new life into existing ones. However, camera-captured documents may suffer from distortions caused by non-planar document shape and perspective projection, which lead to failure of current OCR technologies. We present a geometric rectification framework for restoring the frontal-flat view of a document from a single camera-captured image. Our approach estimates 3D document shape from texture flow information obtained directly from the image without requiring additional 3D/metric data or prior camera calibration. Our framework provides a unified solution for both planar and curved documents and can be applied in many, especially mobile, camera-based document analysis applications. Experiments show that our method produces results that are significantly more OCR compatible than the original images.

Study on law of negative corona discharge in microparticle-air two-phase flow media

NASA Astrophysics Data System (ADS)

He, Bo; Li, Tianwei; Xiu, Yaping; Zhao, Heng; Peng, Zongren; Meng, Yongpeng

2016-03-01

To study the basic law of negative corona discharge in solid particle-air two-phase flow, corona discharge experiments in a needle-plate electrode system at different voltage levels and different wind speed were carried out in the wind tunnel. In this paper, the change law of average current and current waveform were analyzed, and the observed phenomena were systematically explained from the perspectives of airflow, particle charging, and particle motion with the help of PIV (particle image velocity) measurements and ultraviolet observations.

Image contrast enhancement with brightness preservation using an optimal gamma correction and weighted sum approach

NASA Astrophysics Data System (ADS)

Jiang, G.; Wong, C. Y.; Lin, S. C. F.; Rahman, M. A.; Ren, T. R.; Kwok, Ngaiming; Shi, Haiyan; Yu, Ying-Hao; Wu, Tonghai

2015-04-01

The enhancement of image contrast and preservation of image brightness are two important but conflicting objectives in image restoration. Previous attempts based on linear histogram equalization had achieved contrast enhancement, but exact preservation of brightness was not accomplished. A new perspective is taken here to provide balanced performance of contrast enhancement and brightness preservation simultaneously by casting the quest of such solution to an optimization problem. Specifically, the non-linear gamma correction method is adopted to enhance the contrast, while a weighted sum approach is employed for brightness preservation. In addition, the efficient golden search algorithm is exploited to determine the required optimal parameters to produce the enhanced images. Experiments are conducted on natural colour images captured under various indoor, outdoor and illumination conditions. Results have shown that the proposed method outperforms currently available methods in contrast to enhancement and brightness preservation.

The study of electrical conductivity of DNA molecules by scanning tunneling spectroscopy

NASA Astrophysics Data System (ADS)

Sharipov, T. I.; Bakhtizin, R. Z.

2017-10-01

An interest to the processes of charge transport in DNA molecules is very high, due to perspective of their using in nanoelectronics. The original sample preparation for studying electrical conductivity of DNA molecules by scanning tunneling spectroscopy has been proposed and tested. The DNA molecules immobilized on gold surface have been imaged clearly and their current-voltage curves have been measured.

Visual perspective and the characteristics of mind wandering

PubMed Central

Christian, Brittany M.; Miles, Lynden K.; Parkinson, Carolyn; Macrae, C. Neil

2013-01-01

When the mind wanders away from the here-and-now toward imaginary events, it typically does so from one of two visual vantage points—a first-person perspective (i.e., the world is seen as it is in everyday life) or a third-person perspective (i.e., the world is seen from the viewpoint of an outside observer). While extant evidence has detailed consequences that ensue from the utilization of these distinct points of view, less is known about their more basic properties. Here, we investigated the prevalence, demographics and qualities associated with the visual perspective that people spontaneously adopt when the mind wanders. The results from a cross-cultural survey (N = 400) revealed that almost half of the participants (46%) typically utilize a third-person perspective when mind wandering. Further, culture and gender were shown to impact the distribution of first- and third-person imagers. Specifically, a first-person perspective was more common among participants from Western nations and females, while participants from Eastern cultures resonated more strongly with a third-person perspective. Moreover, these factors were also shown to impact qualities (e.g., temporal locus, vividness) of mental imagery. Taken together, the current findings elucidate the prevalence of first- and third-person visual perspectives and detail individual differences that influence the qualia of mind wandering. PMID:24130538

PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives.

PubMed

Zschaeck, Sebastian; Lohaus, Fabian; Beck, Marcus; Habl, Gregor; Kroeze, Stephanie; Zamboglou, Constantinos; Koerber, Stefan Alexander; Debus, Jürgen; Hölscher, Tobias; Wust, Peter; Ganswindt, Ute; Baur, Alexander D J; Zöphel, Klaus; Cihoric, Nikola; Guckenberger, Matthias; Combs, Stephanie E; Grosu, Anca Ligia; Ghadjar, Pirus; Belka, Claus

2018-05-11

68 Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy.This review summarizes the evidence on PSMA-PET imaging from a radiation oncologist's point of view. Additionally a short survey containing twelve examples of patients and 6 additional questions was performed in seven mayor academic centers with experience in PSMA ligand imaging and the findings are reported here.

Targeted radiotherapy with gold nanoparticles: current status and future perspectives

PubMed Central

Ngwa, Wilfred; Kumar, Rajiv; Sridhar, Srinivas; Korideck, Houari; Zygmanski, Piotr; Cormack, Robert A; Berbeco, Ross; Makrigiorgos, G Mike

2014-01-01

Radiation therapy (RT) is the treatment of cancer and other diseases with ionizing radiation. The ultimate goal of RT is to destroy all the disease cells while sparing healthy tissue. Towards this goal, RT has advanced significantly over the past few decades in part due to new technologies including: multileaf collimator-assisted modulation of radiation beams, improved computer-assisted inverse treatment planning, image guidance, robotics with more precision, better motion management strategies, stereotactic treatments and hypofractionation. With recent advances in nanotechnology, targeted RT with gold nanoparticles (GNPs) is actively being investigated as a means to further increase the RT therapeutic ratio. In this review, we summarize the current status of research and development towards the use of GNPs to enhance RT. We highlight the promising emerging modalities for targeted RT with GNPs and the corresponding preclinical evidence supporting such promise towards potential clinical translation. Future prospects and perspectives are discussed. PMID:24978464

Optical character recognition: an illustrated guide to the frontier

NASA Astrophysics Data System (ADS)

Nagy, George; Nartker, Thomas A.; Rice, Stephen V.

1999-12-01

We offer a perspective on the performance of current OCR systems by illustrating and explaining actual OCR errors made by three commercial devices. After discussing briefly the character recognition abilities of humans and computers, we present illustrated examples of recognition errors. The top level of our taxonomy of the causes of errors consists of Imaging Defects, Similar Symbols, Punctuation, and Typography. The analysis of a series of 'snippets' from this perspective provides insight into the strengths and weaknesses of current systems, and perhaps a road map to future progress. The examples were drawn from the large-scale tests conducted by the authors at the Information Science Research Institute of the University of Nevada, Las Vegas. By way of conclusion, we point to possible approaches for improving the accuracy of today's systems. The talk is based on our eponymous monograph, recently published in The Kluwer International Series in Engineering and Computer Science, Kluwer Academic Publishers, 1999.

Article Screening System

NASA Technical Reports Server (NTRS)

Fernandez, Kenneth R. (Inventor)

2004-01-01

During the last ten years patents directed to luggage scanning apparatus began to appear in the patent art. Absent from the variety of approaches in the art is stereoscopic imaging that entails exposing two or more images of the same object, each taken from a slightly different perspective. If the perspectives are too different, that is. if there is too much separation of the X-ray exposures, the image will look flat. Yet with a slight separation, a stereo separation, interference occurs. Herein a system is provided for the production of stereo pairs. One perspective, a left or a right perspective angle, is first established. Next, the other perspective angle is computed. Using these left and right perspectives the X-ray sources can then be spaced away from each other.

Method for producing three-dimensional real image using radiographic perspective views of an object

DOEpatents

Ellingson, William A.; Read, Alvin A.

1976-02-24

A sequence of separate radiographs are made by indexing a radiation source along a known path relative to the object under study. Thus, each radiograph contains information from a different perspective. A holographically-recorded image is then made from each radiographic perspective by exact re-tracing of the rays through each radiographic perspective such that the re-tracing duplicates the geometry under which it was originally prepared. The holographically-stored images are simultaneously illuminated with the conjugate of the reference beam used in the original recordings. The result is the generation of a three-dimensional real image of the object such that a light-sensitive device can be moved to view the real image along any desired surface with the optical information in all other surfaces greatly suppressed.

Imaging and computational considerations for image computed permeability: Operating envelope of Digital Rock Physics

NASA Astrophysics Data System (ADS)

Saxena, Nishank; Hows, Amie; Hofmann, Ronny; Alpak, Faruk O.; Freeman, Justin; Hunter, Sander; Appel, Matthias

2018-06-01

This study defines the optimal operating envelope of the Digital Rock technology from the perspective of imaging and numerical simulations of transport properties. Imaging larger volumes of rocks for Digital Rock Physics (DRP) analysis improves the chances of achieving a Representative Elementary Volume (REV) at which flow-based simulations (1) do not vary with change in rock volume, and (2) is insensitive to the choice of boundary conditions. However, this often comes at the expense of image resolution. This trade-off exists due to the finiteness of current state-of-the-art imaging detectors. Imaging and analyzing digital rocks that sample the REV and still sufficiently resolve pore throats is critical to ensure simulation quality and robustness of rock property trends for further analysis. We find that at least 10 voxels are needed to sufficiently resolve pore throats for single phase fluid flow simulations. If this condition is not met, additional analyses and corrections may allow for meaningful comparisons between simulation results and laboratory measurements of permeability, but some cases may fall outside the current technical feasibility of DRP. On the other hand, we find that the ratio of field of view and effective grain size provides a reliable measure of the REV for siliciclastic rocks. If this ratio is greater than 5, the coefficient of variation for single-phase permeability simulations drops below 15%. These imaging considerations are crucial when comparing digitally computed rock flow properties with those measured in the laboratory. We find that the current imaging methods are sufficient to achieve both REV (with respect to numerical boundary conditions) and required image resolution to perform digital core analysis for coarse to fine-grained sandstones.

Stereo multiplexed holographic particle image velocimeter

DOEpatents

Adrian, Ronald J.; Barnhart, Donald H.; Papen, George A.

1996-01-01

A holographic particle image velocimeter employs stereoscopic recording of particle images, taken from two different perspectives and at two distinct points in time for each perspective, on a single holographic film plate. The different perspectives are provided by two optical assemblies, each including a collecting lens, a prism and a focusing lens. Collimated laser energy is pulsed through a fluid stream, with elements carried in the stream scattering light, some of which is collected by each collecting lens. The respective focusing lenses are configured to form images of the scattered light near the holographic plate. The particle images stored on the plate are reconstructed using the same optical assemblies employed in recording, by transferring the film plate and optical assemblies as a single integral unit to a reconstruction site. At the reconstruction site, reconstruction beams, phase conjugates of the reference beams used in recording the image, are directed to the plate, then selectively through either one of the optical assemblies, to form an image reflecting the chosen perspective at the two points in time.

Stereo multiplexed holographic particle image velocimeter

DOEpatents

Adrian, R.J.; Barnhart, D.H.; Papen, G.A.

1996-08-20

A holographic particle image velocimeter employs stereoscopic recording of particle images, taken from two different perspectives and at two distinct points in time for each perspective, on a single holographic film plate. The different perspectives are provided by two optical assemblies, each including a collecting lens, a prism and a focusing lens. Collimated laser energy is pulsed through a fluid stream, with elements carried in the stream scattering light, some of which is collected by each collecting lens. The respective focusing lenses are configured to form images of the scattered light near the holographic plate. The particle images stored on the plate are reconstructed using the same optical assemblies employed in recording, by transferring the film plate and optical assemblies as a single integral unit to a reconstruction site. At the reconstruction site, reconstruction beams, phase conjugates of the reference beams used in recording the image, are directed to the plate, then selectively through either one of the optical assemblies, to form an image reflecting the chosen perspective at the two points in time. 13 figs.

Brain systems for visual perspective taking and action perception.

PubMed

Mazzarella, Elisabetta; Ramsey, Richard; Conson, Massimiliano; Hamilton, Antonia

2013-01-01

Taking another person's viewpoint and making sense of their actions are key processes that guide social behavior. Previous neuroimaging investigations have largely studied these processes separately. The current study used functional magnetic resonance imaging to examine how the brain incorporates another person's viewpoint and actions into visual perspective judgments. Participants made a left-right judgment about the location of a target object from their own (egocentric) or an actor's visual perspective (altercentric). Actor location varied around a table and the actor was either reaching or not reaching for the target object. Analyses examined brain regions engaged in the egocentric and altercentric tasks, brain regions where response magnitude tracked the orientation of the actor in the scene and brain regions sensitive to the action performed by the actor. The blood oxygen level-dependent (BOLD) response in dorsomedial prefrontal cortex (dmPFC) was sensitive to actor orientation in the altercentric task, whereas the response in right inferior frontal gyrus (IFG) was sensitive to actor orientation in the egocentric task. Thus, dmPFC and right IFG may play distinct but complementary roles in visual perspective taking (VPT). Observation of a reaching actor compared to a non-reaching actor yielded activation in lateral occipitotemporal cortex, regardless of task, showing that these regions are sensitive to body posture independent of social context. By considering how an observed actor's location and action influence the neural bases of visual perspective judgments, the current study supports the view that multiple neurocognitive "routes" operate during VPT.

Practice patterns of image guided particle therapy in Europe: A 2016 survey of the European Particle Therapy Network (EPTN).

PubMed

Bolsi, Alessandra; Peroni, Marta; Amelio, Dante; Dasu, Alexandru; Stock, Markus; Toma-Dasu, Iuliana; Nyström, Petra Witt; Hoffmann, Aswin

2018-03-28

Image guidance is critical in achieving accurate and precise radiation delivery in particle therapy, even more than in photon therapy. However, equipment, quality assurance procedures and clinical workflows for image-guided particle therapy (IGPT) may vary substantially between centres due to a lack of standardization. A survey was conducted to evaluate the current practice of IGPT in European particle therapy centres. In 2016, a questionnaire was distributed among 19 particle therapy centres in 12 European countries. The questionnaire consisted of 30 open and 37 closed questions related to image guidance in the general clinical workflow, for moving targets, current research activities and future perspectives of IGPT. All centres completed the questionnaire. The IGPT methods used by the 10 treating centres varied substantially. The 9 non-treating centres were in the process to introduce IGPT. Most centres have developed their own IGPT strategies, being tightly connected to their specific technical implementation and dose delivery methods. Insight into the current clinical practice of IGPT in European particle therapy centres was obtained. A variety in IGPT practices and procedures was confirmed, which underlines the need for harmonisation of practice parameters and consensus guidelines. Copyright © 2018 Elsevier B.V. All rights reserved.

Real-time fMRI neurofeedback: Progress and challenges

PubMed Central

Sulzer, J.; Haller, S.; Scharnowski, F.; Weiskopf, N.; Birbaumer, N.; Blefari, M.L.; Bruehl, A.B.; Cohen, L.G.; deCharms, R.C.; Gassert, R.; Goebel, R.; Herwig, U.; LaConte, S.; Linden, D.; Luft, A.; Seifritz, E.; Sitaram, R.

2016-01-01

In February of 2012, the first international conference on real time functional magnetic resonance imaging (rtfMRI) neurofeedback was held at the Swiss Federal Institute of Technology Zurich (ETHZ), Switzerland. This review summarizes progress in the field, introduces current debates, elucidates open questions, and offers viewpoints derived from the conference. The review offers perspectives on study design, scientific and clinical applications, rtfMRI learning mechanisms and future outlook. PMID:23541800

A review of GPU-based medical image reconstruction.

PubMed

Després, Philippe; Jia, Xun

2017-10-01

Tomographic image reconstruction is a computationally demanding task, even more so when advanced models are used to describe a more complete and accurate picture of the image formation process. Such advanced modeling and reconstruction algorithms can lead to better images, often with less dose, but at the price of long calculation times that are hardly compatible with clinical workflows. Fortunately, reconstruction tasks can often be executed advantageously on Graphics Processing Units (GPUs), which are exploited as massively parallel computational engines. This review paper focuses on recent developments made in GPU-based medical image reconstruction, from a CT, PET, SPECT, MRI and US perspective. Strategies and approaches to get the most out of GPUs in image reconstruction are presented as well as innovative applications arising from an increased computing capacity. The future of GPU-based image reconstruction is also envisioned, based on current trends in high-performance computing. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Multifunctional Inorganic Nanoparticles: Recent Progress in Thermal Therapy and Imaging

PubMed Central

Cherukula, Kondareddy; Manickavasagam Lekshmi, Kamali; Uthaman, Saji; Cho, Kihyun; Cho, Chong-Su; Park, In-Kyu

2016-01-01

Nanotechnology has enabled the development of many alternative anti-cancer approaches, such as thermal therapies, which cause minimal damage to healthy cells. Current challenges in cancer treatment are the identification of the diseased area and its efficient treatment without generating many side effects. Image-guided therapies can be a useful tool to diagnose and treat the diseased tissue and they offer therapy and imaging using a single nanostructure. The present review mainly focuses on recent advances in the field of thermal therapy and imaging integrated with multifunctional inorganic nanoparticles. The main heating sources for heat-induced therapies are the surface plasmon resonance (SPR) in the near infrared region and alternating magnetic fields (AMFs). The different families of inorganic nanoparticles employed for SPR- and AMF-based thermal therapies and imaging are described. Furthermore, inorganic nanomaterials developed for multimodal therapies with different and multi-imaging modalities are presented in detail. Finally, relevant clinical perspectives and the future scope of inorganic nanoparticles in image-guided therapies are discussed. PMID:28335204

Radionuclide Imaging of Neurohormonal System of the Heart

PubMed Central

Chen, Xinyu; Werner, Rudolf A.; Javadi, Mehrbod S.; Maya, Yoshifumi; Decker, Michael; Lapa, Constantin; Herrmann, Ken; Higuchi, Takahiro

2015-01-01

Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included. PMID:25825596

Positron emission tomography/magnetic resonance imaging (PET/MRI): An update and initial experience at HC-FMUSP.

PubMed

Queiroz, Marcelo A; Barbosa, Felipe de Galiza; Buchpiguel, Carlos Alberto; Cerri, Giovanni Guido

2018-01-01

The new technology of PET/MRI is a prototype of hybrid imaging, allowing for the combination of molecular data from PET scanning and morphofunctional information derived from MRI scanning. Recent advances regarding the technical aspects of this device, especially after the development of MRI-compatible silicon photomultipliers of PET, permitted an increase in the diagnostic performance of PET/MRI translated into dose reduction and higher imaging quality. Among several clinical applications, PET/MRI gains ground initially in oncology, where MRI per se plays an essential role in the assessment of primary tumors (which is limited in the case of PET/CT), including prostate, rectal and gynecological tumors. On the other hand, the evaluation of the lungs remains an enigma although new MRI sequences are being designed to overcome this. More clinical indications of PET/MRI are seen in the fields of neurology, cardiology and inflammatory processes, and the use of PET/MRI also opens perspectives for pediatric populations as it involves very low radiation exposure. Our review aimed to highlight the current indications of PET/MRI and discuss the challenges and perspectives of PET/MRI at HC-FMUSP.

Magnetic resonance spectroscopic imaging at superresolution: Overview and perspectives.

PubMed

Kasten, Jeffrey; Klauser, Antoine; Lazeyras, François; Van De Ville, Dimitri

2016-02-01

The notion of non-invasive, high-resolution spatial mapping of metabolite concentrations has long enticed the medical community. While magnetic resonance spectroscopic imaging (MRSI) is capable of achieving the requisite spatio-spectral localization, it has traditionally been encumbered by significant resolution constraints that have thus far undermined its clinical utility. To surpass these obstacles, research efforts have primarily focused on hardware enhancements or the development of accelerated acquisition strategies to improve the experimental sensitivity per unit time. Concomitantly, a number of innovative reconstruction techniques have emerged as alternatives to the standard inverse discrete Fourier transform (DFT). While perhaps lesser known, these latter methods strive to effect commensurate resolution gains by exploiting known properties of the underlying MRSI signal in concert with advanced image and signal processing techniques. This review article aims to aggregate and provide an overview of the past few decades of so-called "superresolution" MRSI reconstruction methodologies, and to introduce readers to current state-of-the-art approaches. A number of perspectives are then offered as to the future of high-resolution MRSI, with a particular focus on translation into clinical settings. Copyright © 2015 Elsevier Inc. All rights reserved.

Modeling of electron-specimen interaction in scanning electron microscope for e-beam metrology and inspection: challenges and perspectives

NASA Astrophysics Data System (ADS)

Suzuki, Makoto; Kameda, Toshimasa; Doi, Ayumi; Borisov, Sergey; Babin, Sergey

2018-03-01

The interpretation of scanning electron microscopy (SEM) images of the latest semiconductor devices is not intuitive and requires comparison with computed images based on theoretical modeling and simulations. For quantitative image prediction and geometrical reconstruction of the specimen structure, the accuracy of the physical model is essential. In this paper, we review the current models of electron-solid interaction and discuss their accuracy. We perform the comparison of the simulated results with our experiments of SEM overlay of under-layer, grain imaging of copper interconnect, and hole bottom visualization by angular selective detectors, and show that our model well reproduces the experimental results. Remaining issues for quantitative simulation are also discussed, including the accuracy of the charge dynamics, treatment of beam skirt, and explosive increase in computing time.

On the Development of a Computing Infrastructure that Facilitates IPPD from a Decision-Based Design Perspective

NASA Technical Reports Server (NTRS)

Hale, Mark A.; Craig, James I.; Mistree, Farrokh; Schrage, Daniel P.

1995-01-01

Integrated Product and Process Development (IPPD) embodies the simultaneous application of both system and quality engineering methods throughout an iterative design process. The use of IPPD results in the time-conscious, cost-saving development of engineering systems. Georgia Tech has proposed the development of an Integrated Design Engineering Simulator that will merge Integrated Product and Process Development with interdisciplinary analysis techniques and state-of-the-art computational technologies. To implement IPPD, a Decision-Based Design perspective is encapsulated in an approach that focuses on the role of the human designer in product development. The approach has two parts and is outlined in this paper. First, an architecture, called DREAMS, is being developed that facilitates design from a decision-based perspective. Second, a supporting computing infrastructure, called IMAGE, is being designed. The current status of development is given and future directions are outlined.

Advances in Clinical and Biomedical Applications of Photoacoustic Imaging

PubMed Central

Su, Jimmy L.; Wang, Bo; Wilson, Katheryne E.; Bayer, Carolyn L.; Chen, Yun-Sheng; Kim, Seungsoo; Homan, Kimberly A.; Emelianov, Stanislav Y.

2010-01-01

Importance of the field Photoacoustic imaging is an imaging modality that derives image contrast from the optical absorption coefficient of the tissue being imaged. The imaging technique is able to differentiate between healthy and diseased tissue with either deeper penetration or higher resolution than other functional imaging modalities currently available. From a clinical standpoint, photoacoustic imaging has demonstrated safety and effectiveness in diagnosing diseased tissue regions using either endogenous tissue contrast or exogenous contrast agents. Furthermore, the potential of photoacoustic imaging has been demonstrated in various therapeutic interventions ranging from drug delivery and release to image-guided therapy and monitoring. Areas covered in this review This article reviews the current state of photoacoustic imaging in biomedicine from a technological perspective, highlights various biomedical and clinical applications of photoacoustic imaging, and gives insights on future directions. What the reader will gain Readers will learn about the various applications of photoacoustic imaging, as well as the various contrast agents that can be used to assist photoacoustic imaging. This review will highlight both pre-clinical and clinical uses for photoacoustic imaging, as well as discuss some of the challenges that must be addressed to move photoacoustic imaging into the clinical realm. Take home message Photoacoustic imaging offers unique advantages over existing imaging modalities. The imaging field is broad with many exciting applications for detecting and diagnosing diseased tissue or processes. Photoacoustics is also used in therapeutic applications to identify and characterize the pathology and then to monitor the treatment. Although the technology is still in its infancy, much work has been done in the pre-clinical arena, and photoacoustic imaging is fast approaching the clinical setting. PMID:21344060

Remembering from any angle: The flexibility of visual perspective during retrieval

PubMed Central

Rice, Heather J.; Rubin, David C.

2010-01-01

When recalling autobiographical memories, individuals often experience visual images associated with the event. These images can be constructed from two different perspectives: first person, in which the event is visualized from the viewpoint experienced at encoding, or third person, in which the event is visualized from an external vantage point. Using a novel technique to measure visual perspective, we examined where the external vantage point is situated in third-person images. Individuals in two studies were asked to recall either 10 or 15 events from their lives and describe the perspectives they experienced. Wide variation in spatial locations was observed within third-person perspectives, with the location of these perspectives depending on the event being recalled. Results suggest remembering from an external viewpoint may be more common than previous studies have demonstrated. PMID:21109466

Spheres of Earth: An Introduction to Making Observations of Earth Using an Earth System's Science Approach. Student Guide

NASA Technical Reports Server (NTRS)

Graff, Paige Valderrama; Baker, Marshalyn (Editor); Graff, Trevor (Editor); Lindgren, Charlie (Editor); Mailhot, Michele (Editor); McCollum, Tim (Editor); Runco, Susan (Editor); Stefanov, William (Editor); Willis, Kim (Editor)

2010-01-01

Scientists from the Image Science and Analysis Laboratory (ISAL) at NASA's Johnson Space Center (JSC) work with astronauts onboard the International Space Station (ISS) who take images of Earth. Astronaut photographs, sometimes referred to as Crew Earth Observations, are taken using hand-held digital cameras onboard the ISS. These digital images allow scientists to study our Earth from the unique perspective of space. Astronauts have taken images of Earth since the 1960s. There is a database of over 900,000 astronaut photographs available at http://eol.jsc.nasa.gov . Images are requested by ISAL scientists at JSC and astronauts in space personally frame and acquire them from the Destiny Laboratory or other windows in the ISS. By having astronauts take images, they can specifically frame them according to a given request and need. For example, they can choose to use different lenses to vary the amount of area (field of view) an image will cover. Images can be taken at different times of the day which allows different lighting conditions to bring out or highlight certain features. The viewing angle at which an image is acquired can also be varied to show the same area from different perspectives. Pointing the camera straight down gives you a nadir shot. Pointing the camera at an angle to get a view across an area would be considered an oblique shot. Being able to change these variables makes astronaut photographs a unique and useful data set. Astronaut photographs are taken from the ISS from altitudes of 300 - 400 km (185 to 250 miles). One of the current cameras being used, the Nikon D3X digital camera, can take images using a 50, 100, 250, 400 or 800mm lens. These different lenses allow for a wider or narrower field of view. The higher the focal length (800mm for example) the narrower the field of view (less area will be covered). Higher focal lengths also show greater detail of the area on the surface being imaged. Scientists from the Image Science and Analysis Laboratory (ISAL) at NASA s Johnson Space Center (JSC) work with astronauts onboard the International Space Station (ISS) who take images of Earth. Astronaut photographs, sometimes referred to as Crew Earth Observations, are taken using hand-held digital cameras onboard the ISS. These digital images allow scientists to study our Earth from the unique perspective of space. Astronauts have taken images of Earth since the 1960s. There is a database of over 900,000 astronaut photographs available at http://eol.jsc.nasa.gov . Images are requested by ISAL scientists at JSC and astronauts in space personally frame and acquire them from the Destiny Laboratory or other windows in the ISS. By having astronauts take images, they can specifically frame them according to a given request and need. For example, they can choose to use different lenses to vary the amount of area (field of view) an image will cover. Images can be taken at different times of the day which allows different lighting conditions to bring out or highlight certain features. The viewing angle at which an image is acquired can also be varied to show the same area from different perspectives. Pointing the camera straight down gives you a nadir shot. Pointing the camera at an angle to get a view across an area would be considered an oblique shot. Being able to change these variables makes astronaut photographs a unique and useful data set. Astronaut photographs are taken from the ISS from altitudes of 300 - 400 km (approx.185 to 250 miles). One of the current cameras being used, the Nikon D3X digital camera, can take images using a 50, 100, 250, 400 or 800mm lens. These different lenses allow for a wider or narrower field of view. The higher the focal length (800mm for example) the narrower the field of view (less area will be covered). Higher focal lengths also show greater detail of the area on the surface being imaged. There are four major systems or spheres of Earth. They are: Atmosphere, Biosphere, Hydrosphe, and Litho/Geosphere.

Endoscopic ultrasound: Elastographic lymph node evaluation.

PubMed

Dietrich, Christoph F; Jenssen, Christian; Arcidiacono, Paolo G; Cui, Xin-Wu; Giovannini, Marc; Hocke, Michael; Iglesias-Garcia, Julio; Saftoiu, Adrian; Sun, Siyu; Chiorean, Liliana

2015-01-01

Different imaging techniques can bring different information which will contribute to the final diagnosis and further management of the patients. Even from the time of Hippocrates, palpation has been used in order to detect and characterize a body mass. The so-called virtual palpation has now become a reality due to elastography, which is a recently developed technique. Elastography has already been proving its added value as a complementary imaging method, helpful to better characterize and differentiate between benign and malignant masses. The current applications of elastography in lymph nodes (LNs) assessment by endoscopic ultrasonography will be further discussed in this paper, with a review of the literature and future perspectives.

Steganalysis feature improvement using expectation maximization

NASA Astrophysics Data System (ADS)

Rodriguez, Benjamin M.; Peterson, Gilbert L.; Agaian, Sos S.

2007-04-01

Images and data files provide an excellent opportunity for concealing illegal or clandestine material. Currently, there are over 250 different tools which embed data into an image without causing noticeable changes to the image. From a forensics perspective, when a system is confiscated or an image of a system is generated the investigator needs a tool that can scan and accurately identify files suspected of containing malicious information. The identification process is termed the steganalysis problem which focuses on both blind identification, in which only normal images are available for training, and multi-class identification, in which both the clean and stego images at several embedding rates are available for training. In this paper an investigation of a clustering and classification technique (Expectation Maximization with mixture models) is used to determine if a digital image contains hidden information. The steganalysis problem is for both anomaly detection and multi-class detection. The various clusters represent clean images and stego images with between 1% and 10% embedding percentage. Based on the results it is concluded that the EM classification technique is highly suitable for both blind detection and the multi-class problem.

Image guidance in orthopaedics and traumatology: A historical perspective.

PubMed

Székely, Gabor; Nolte, Lutz-P

2016-10-01

In this note we summarize the history of computer aided surgery in orthopaedics and traumatology from the end of the nineteenth century to currently observable future trends. We concentrate on the two major components of such systems, pre-operative planning and intra-operative execution. The evolution of the necessary technological components, the numerous platforms and components offered commercially as well as their clinical use are surveyed. Copyright © 2016. Published by Elsevier B.V.

Contrast-enhanced magnetic resonance angiography for preoperative imaging of deep inferior epigastric artery perforator flaps: advantages and disadvantages compared with computed tomography angiography: a United Kingdom perspective.

PubMed

Schaverien, Mark V; Ludman, Catherine N; Neil-Dwyer, Jason; McCulley, Stephen J

2011-12-01

The anatomy of the anterior abdominal wall is highly variable and leads to uncertainty when harvesting a deep inferior epigastric artery perforator flap. Presurgical imaging has been shown to reduce the operating time, as well as reduce the rates of flap and donor site complications. The importance of imaging of the venous system has also been recognized for reducing the risk of venous congestion. The modalities currently available for presurgical imaging include handheld Doppler ultrasound, duplex ultrasound, computed tomographic angiography (CTA), and contrast-enhanced magnetic resonance angiography (CE-MRA). Of these, the most promising are CTA and CE-MRA, and advantages and disadvantages exist for both modalities. In this article, we review the use of CE-MRA for preoperative flap imaging and report our experience with its use in deep inferior epigastric artery perforator flap harvest, as well as compare it with CTA. We also explore the future directions for presurgical flap imaging.

Descriptive and Computer Aided Drawing Perspective on an Unfolded Polyhedral Projection Surface

NASA Astrophysics Data System (ADS)

Dzwierzynska, Jolanta

2017-10-01

The aim of the herby study is to develop a method of direct and practical mapping of perspective on an unfolded prism polyhedral projection surface. The considered perspective representation is a rectilinear central projection onto a surface composed of several flat elements. In the paper two descriptive methods of drawing perspective are presented: direct and indirect. The graphical mapping of the effects of the representation is realized directly on the unfolded flat projection surface. That is due to the projective and graphical connection between points displayed on the polyhedral background and their counterparts received on the unfolded flat surface. For a significant improvement of the construction of line, analytical algorithms are formulated. They draw a perspective image of a segment of line passing through two different points determined by their coordinates in a spatial coordinate system of axis x, y, z. Compared to other perspective construction methods that use information about points, for computer vision and the computer aided design, our algorithms utilize data about lines, which are applied very often in architectural forms. Possibility of drawing lines in the considered perspective enables drawing an edge perspective image of an architectural object. The application of the changeable base elements of perspective as a horizon height and a station point location enable drawing perspective image from different viewing positions. The analytical algorithms for drawing perspective images are formulated in Mathcad software, however, they can be implemented in the majority of computer graphical packages, which can make drawing perspective more efficient and easier. The representation presented in the paper and the way of its direct mapping on the flat unfolded projection surface can find application in presentation of architectural space in advertisement and art.

Establishing Base Elements of Perspective in Order to Reconstruct Architectural Buildings from Photographs

NASA Astrophysics Data System (ADS)

Dzwierzynska, Jolanta

2017-12-01

The use of perspective images, especially historical photographs for retrieving information about presented architectural environment is a fast developing field recently. The photography image is a perspective image with secure geometrical connection with reality, therefore it is possible to reverse this process. The aim of the herby study is establishing requirements which a photographic perspective representation should meet for a reconstruction purpose, as well as determination of base elements of perspective such as a horizon line and a circle of depth, which is a key issue in any reconstruction. The starting point in the reconstruction process is geometrical analysis of the photograph, especially determination of the kind of perspective projection applied, which is defined by the building location towards a projection plane. Next, proper constructions can be used. The paper addresses the problem of establishing base elements of perspective on the basis of the photograph image in the case when camera calibration is impossible to establish. It presents different geometric construction methods selected dependently on the starting assumptions. Therefore, the methods described in the paper seem to be universal. Moreover, they can be used even in the case of poor quality photographs with poor perspective geometry. Such constructions can be realized with computer aid when the photographs are in digital form as it is presented in the paper. The accuracy of the applied methods depends on the photography image accuracy, as well as drawing accuracy, however, it is sufficient for further reconstruction. Establishing base elements of perspective presented in the paper is especially useful in difficult cases of reconstruction, when one lacks information about reconstructed architectural form and it is necessary to lean on solid geometry.

Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

PubMed Central

Ontaneda, Daniel; Fox, Robert J.; Chataway, Jeremy

2015-01-01

Progressive multiple sclerosis is characterized by the gradual accrual of disability independent of relapses and can occur with disease onset (primary progressive) or preceded by a relapsing disease course (secondary progressive). An effective disease modifying treatment for progressive multiple sclerosis has not been identified, and the results of clinical trials to date have been generally disappointing. Ongoing advances in our understanding of pathogenesis, identification of novel targets for neuro-protection, and improved outcome measures have the potential to lead to effective treatments for progressive multiple sclerosis. In this review lessons learned from previous clinical trials and perspectives from current trials in progressive multiple sclerosis are summarized. Promising clinical, imaging, and biological markers will also be reviewed, along with novel clinical trial designs. PMID:25772899

Current Status and Future Perspectives of Mass Spectrometry Imaging

PubMed Central

Nimesh, Surendra; Mohottalage, Susantha; Vincent, Renaud; Kumarathasan, Prem

2013-01-01

Mass spectrometry imaging is employed for mapping proteins, lipids and metabolites in biological tissues in a morphological context. Although initially developed as a tool for biomarker discovery by imaging the distribution of protein/peptide in tissue sections, the high sensitivity and molecular specificity of this technique have enabled its application to biomolecules, other than proteins, even in cells, latent finger prints and whole organisms. Relatively simple, with no requirement for labelling, homogenization, extraction or reconstitution, the technique has found a variety of applications in molecular biology, pathology, pharmacology and toxicology. By discriminating the spatial distribution of biomolecules in serial sections of tissues, biomarkers of lesions and the biological responses to stressors or diseases can be better understood in the context of structure and function. In this review, we have discussed the advances in the different aspects of mass spectrometry imaging processes, application towards different disciplines and relevance to the field of toxicology. PMID:23759983

Calcium neuroimaging in behaving zebrafish larvae using a turn-key light field camera

NASA Astrophysics Data System (ADS)

Cruz Perez, Carlos; Lauri, Antonella; Symvoulidis, Panagiotis; Cappetta, Michele; Erdmann, Arne; Westmeyer, Gil Gregor

2015-09-01

Reconstructing a three-dimensional scene from multiple simultaneously acquired perspectives (the light field) is an elegant scanless imaging concept that can exceed the temporal resolution of currently available scanning-based imaging methods for capturing fast cellular processes. We tested the performance of commercially available light field cameras on a fluorescent microscopy setup for monitoring calcium activity in the brain of awake and behaving reporter zebrafish larvae. The plenoptic imaging system could volumetrically resolve diverse neuronal response profiles throughout the zebrafish brain upon stimulation with an aversive odorant. Behavioral responses of the reporter fish could be captured simultaneously together with depth-resolved neuronal activity. Overall, our assessment showed that with some optimizations for fluorescence microscopy applications, commercial light field cameras have the potential of becoming an attractive alternative to custom-built systems to accelerate molecular imaging research on cellular dynamics.

Calcium neuroimaging in behaving zebrafish larvae using a turn-key light field camera.

PubMed

Perez, Carlos Cruz; Lauri, Antonella; Symvoulidis, Panagiotis; Cappetta, Michele; Erdmann, Arne; Westmeyer, Gil Gregor

2015-09-01

Reconstructing a three-dimensional scene from multiple simultaneously acquired perspectives (the light field) is an elegant scanless imaging concept that can exceed the temporal resolution of currently available scanning-based imaging methods for capturing fast cellular processes. We tested the performance of commercially available light field cameras on a fluorescent microscopy setup for monitoring calcium activity in the brain of awake and behaving reporter zebrafish larvae. The plenoptic imaging system could volumetrically resolve diverse neuronal response profiles throughout the zebrafish brain upon stimulation with an aversive odorant. Behavioral responses of the reporter fish could be captured simultaneously together with depth-resolved neuronal activity. Overall, our assessment showed that with some optimizations for fluorescence microscopy applications, commercial light field cameras have the potential of becoming an attractive alternative to custom-built systems to accelerate molecular imaging research on cellular dynamics.

Vision 20/20: perspectives on automated image segmentation for radiotherapy.

PubMed

Sharp, Gregory; Fritscher, Karl D; Pekar, Vladimir; Peroni, Marta; Shusharina, Nadya; Veeraraghavan, Harini; Yang, Jinzhong

2014-05-01

Due to rapid advances in radiation therapy (RT), especially image guidance and treatment adaptation, a fast and accurate segmentation of medical images is a very important part of the treatment. Manual delineation of target volumes and organs at risk is still the standard routine for most clinics, even though it is time consuming and prone to intra- and interobserver variations. Automated segmentation methods seek to reduce delineation workload and unify the organ boundary definition. In this paper, the authors review the current autosegmentation methods particularly relevant for applications in RT. The authors outline the methods' strengths and limitations and propose strategies that could lead to wider acceptance of autosegmentation in routine clinical practice. The authors conclude that currently, autosegmentation technology in RT planning is an efficient tool for the clinicians to provide them with a good starting point for review and adjustment. Modern hardware platforms including GPUs allow most of the autosegmentation tasks to be done in a range of a few minutes. In the nearest future, improvements in CT-based autosegmentation tools will be achieved through standardization of imaging and contouring protocols. In the longer term, the authors expect a wider use of multimodality approaches and better understanding of correlation of imaging with biology and pathology.

Vision 20/20: Perspectives on automated image segmentation for radiotherapy

PubMed Central

Sharp, Gregory; Fritscher, Karl D.; Pekar, Vladimir; Peroni, Marta; Shusharina, Nadya; Veeraraghavan, Harini; Yang, Jinzhong

2014-01-01

Due to rapid advances in radiation therapy (RT), especially image guidance and treatment adaptation, a fast and accurate segmentation of medical images is a very important part of the treatment. Manual delineation of target volumes and organs at risk is still the standard routine for most clinics, even though it is time consuming and prone to intra- and interobserver variations. Automated segmentation methods seek to reduce delineation workload and unify the organ boundary definition. In this paper, the authors review the current autosegmentation methods particularly relevant for applications in RT. The authors outline the methods’ strengths and limitations and propose strategies that could lead to wider acceptance of autosegmentation in routine clinical practice. The authors conclude that currently, autosegmentation technology in RT planning is an efficient tool for the clinicians to provide them with a good starting point for review and adjustment. Modern hardware platforms including GPUs allow most of the autosegmentation tasks to be done in a range of a few minutes. In the nearest future, improvements in CT-based autosegmentation tools will be achieved through standardization of imaging and contouring protocols. In the longer term, the authors expect a wider use of multimodality approaches and better understanding of correlation of imaging with biology and pathology. PMID:24784366

Synchronous brain activity across individuals underlies shared psychological perspectives

PubMed Central

Lahnakoski, Juha M.; Glerean, Enrico; Jääskeläinen, Iiro P.; Hyönä, Jukka; Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri

2014-01-01

For successful communication, we need to understand the external world consistently with others. This task requires sufficiently similar cognitive schemas or psychological perspectives that act as filters to guide the selection, interpretation and storage of sensory information, perceptual objects and events. Here we show that when individuals adopt a similar psychological perspective during natural viewing, their brain activity becomes synchronized in specific brain regions. We measured brain activity with functional magnetic resonance imaging (fMRI) from 33 healthy participants who viewed a 10-min movie twice, assuming once a ‘social’ (detective) and once a ‘non-social’ (interior decorator) perspective to the movie events. Pearson's correlation coefficient was used to derive multisubject voxelwise similarity measures (inter-subject correlations; ISCs) of functional MRI data. We used k-nearest-neighbor and support vector machine classifiers as well as a Mantel test on the ISC matrices to reveal brain areas wherein ISC predicted the participants' current perspective. ISC was stronger in several brain regions—most robustly in the parahippocampal gyrus, posterior parietal cortex and lateral occipital cortex—when the participants viewed the movie with similar rather than different perspectives. Synchronization was not explained by differences in visual sampling of the movies, as estimated by eye gaze. We propose that synchronous brain activity across individuals adopting similar psychological perspectives could be an important neural mechanism supporting shared understanding of the environment. PMID:24936687

Challenges to Global Implementation of Infrared Thermography Technology: Current Perspective

PubMed Central

Shterenshis, Michael

2017-01-01

Medical infrared thermography (IT) produces an image of the infrared waves emitted by the human body as part of the thermoregulation process that can vary in intensity based on the health of the person. This review analyzes recent developments in the use of infrared thermography as a screening and diagnostic tool in clinical and nonclinical settings, and identifies possible future routes for improvement of the method. Currently, infrared thermography is not considered to be a fully reliable diagnostic method. If standard infrared protocol is established and a normative database is available, infrared thermography may become a reliable method for detecting inflammatory processes. PMID:29138741

Challenges to Global Implementation of Infrared Thermography Technology: Current Perspective.

PubMed

Shterenshis, Michael

2017-01-01

Medical infrared thermography (IT) produces an image of the infrared waves emitted by the human body as part of the thermoregulation process that can vary in intensity based on the health of the person. This review analyzes recent developments in the use of infrared thermography as a screening and diagnostic tool in clinical and nonclinical settings, and identifies possible future routes for improvement of the method. Currently, infrared thermography is not considered to be a fully reliable diagnostic method. If standard infrared protocol is established and a normative database is available, infrared thermography may become a reliable method for detecting inflammatory processes.

Observer perspective imagery with stuttering.

PubMed

Lowe, Robyn; Menzies, Ross; Packman, Ann; O'Brian, Sue; Onslow, Mark

2015-01-01

Adults who stutter are at risk of developing a range of psychological conditions. Social anxiety disorder is the most common anxiety disorder associated with stuttering. Observer perspective imagery is one cognitive process involved in the maintenance of some anxiety disorders. This involves viewing images as if looking at the self from the perspective of another. In contrast, the field perspective involves looking out from the self at the surrounding environment. The purpose of this study was to assess the presence of observer perspective imagery with stuttering. The authors administered the Hackmann, Surawy and Clark (1998) semi-structured interview to 30 adults who stutter and 30 controls. Group images and impressions were compared for frequency, perspective recalled and emotional valence. The stuttering group was significantly more likely than controls to recall images and impressions from an observer rather than a field perspective for anxious situations. It is possible the present results could reflect the same attentional processing bias that occurs with anxiety disorders in the non-stuttering population. These preliminary results provide an explanation for the persistence of conditions such as social anxiety disorder with stuttering. Clinical implications are discussed.

Status and Perspectives of Neutron Imaging Facilities

NASA Astrophysics Data System (ADS)

Lehmann, E.; Trtik, P.; Ridikas, D.

The methodology and the application range of neutron imaging techniques have been significantly improved at numerous facilities worldwide in the last decades. This progress has been achieved by new detector systems, the setup of dedicated, optimized and flexible beam lines and the much better understanding of the complete imaging process thanks to complementary simulations. Furthermore, new applications and research topics were found and implemented. However, since the quality and the number of neutron imaging facilities depend much on the access to suitable beam ports, there is still an enormous potential to implement state-of-the-art neutron imaging techniques at many more facilities. On the one hand, there are prominent and powerful sources which do not intend/accept the implementation of neutron imaging techniques due to the priorities set for neutron scattering and irradiation techniques exclusively. On the other hand, there are modern and useful devices which remain under-utilized and have either not the capacity or not the know-how to develop attractive user programs and/or industrial partnerships. In this overview of the international status of neutron imaging facilities, we will specify details about the current situation.

A perspective on high-frequency ultrasound for medical applications

NASA Astrophysics Data System (ADS)

Mamou, Jonathan; Aristizába, Orlando; Silverman, Ronald H.; Ketterling, Jeffrey A.

2010-01-01

High-frequency ultrasound (HFU, >15 MHz) is a rapidly developing field. HFU is currently used and investigated for ophthalmologic, dermatologic, intravascular, and small-animal imaging. HFU offers a non-invasive means to investigate tissue at the microscopic level with resolutions often better than 100 μm. However, fine resolution is only obtained over the limited depth-of-field (˜1 mm) of single-element spherically-focused transducers typically used for HFU applications. Another limitation is penetration depth because most biological tissues have large attenuation at high frequencies. In this study, two 5-element annular arrays with center frequencies of 17 and 34 MHz were fabricated and methods were developed to obtain images with increased penetration depth and depth-of-field. These methods were used in ophthalmologic and small-animal imaging studies. Improved blood sensitivity was obtained when a phantom mimicking a vitreous hemorrhage was imaged. Central-nervous systems of 12.5-day-old mouse embryos were imaged in utero and in three dimensions for the first time.

Dynamic x-ray imaging of laser-driven nanoplasmas

NASA Astrophysics Data System (ADS)

Fennel, Thomas

2016-05-01

A major promise of current x-ray science at free electron lasers is the realization of unprecedented imaging capabilities for resolving the structure and ultrafast dynamics of matter with nanometer spatial and femtosecond temporal resolution or even below via single-shot x-ray diffraction. Laser-driven atomic clusters and nanoparticles provide an ideal platform for developing and demonstrating the required technology to extract the ultrafast transient spatiotemporal dynamics from the diffraction images. In this talk, the perspectives and challenges of dynamic x-ray imaging will be discussed using complete self-consistent microscopic electromagnetic simulations of IR pump x-ray probe imaging for the example of clusters. The results of the microscopic particle-in-cell simulations (MicPIC) enable the simulation-assisted reconstruction of corresponding experimental data. This capability is demonstrated by converting recently measured LCLS data into a ultrahigh resolution movie of laser-induced plasma expansion. Finally, routes towards reaching attosecond time resolution in the visualization of complex dynamical processes in matter by x-ray diffraction will be discussed.

Recent Advances in Techniques for Hyperspectral Image Processing

NASA Technical Reports Server (NTRS)

Plaza, Antonio; Benediktsson, Jon Atli; Boardman, Joseph W.; Brazile, Jason; Bruzzone, Lorenzo; Camps-Valls, Gustavo; Chanussot, Jocelyn; Fauvel, Mathieu; Gamba, Paolo; Gualtieri, Anthony;

The contribution of physics to Nuclear Medicine: physicians' perspective on future directions.

PubMed

Mankoff, David A; Pryma, Daniel A

2014-12-01

Advances in Nuclear Medicine physics enabled the specialty of Nuclear Medicine and directed research in other aspects of radiotracer imaging, ultimately leading to Nuclear Medicine's emergence as an important component of current medical practice. Nuclear Medicine's unique ability to characterize in vivo biology without perturbing it will assure its ongoing role in a practice of medicine increasingly driven by molecular biology. However, in the future, it is likely that advances in molecular biology and radiopharmaceutical chemistry will increasingly direct future developments in Nuclear Medicine physics, rather than relying on physics as the primary driver of advances in Nuclear Medicine. Working hand-in-hand with clinicians, chemists, and biologists, Nuclear Medicine physicists can greatly enhance the specialty by creating more sensitive and robust imaging devices, by enabling more facile and sophisticated image analysis to yield quantitative measures of regional in vivo biology, and by combining the strengths of radiotracer imaging with other imaging modalities in hybrid devices, with the overall goal to enhance Nuclear Medicine's ability to characterize regional in vivo biology.

Towards practical implementation of biophotonics-based solutions for cost-effective monitoring of food quality control (Conference Presentation)

NASA Astrophysics Data System (ADS)

Meglinski, Igor; Popov, Alexey; Bykov, Alexander

2017-03-01

Biophotonics-based diagnostic and imaging modalities have been widely used in various applications associated with the non-invasive imaging of the internal structure of a range biological media from a range of cells cultures to biological tissues. With the fast growing interest in food securities there remains strong demand to apply reliable and cost effective biophotonics-based technologies for rapid screening of freshness, internal defects and quality of major agricultural products. In current presentation the results of application of optical coherence tomography (OCT) and encapsulated optical bio-sensors for quantitative assessment of freshness of agricultural products, such as meat and sea foods, are presented, and their further perspectives are discussed.

OCT in the field of laryngology: further perspectives

NASA Astrophysics Data System (ADS)

Just, T.; Pau, H. W.; Lankenau, E.; Hüttmann, G.

2011-03-01

Early detection of cancerous lesions of the larynx may be the best method of improving patient quality of life and survival rates. New in-vivo technologies may be of great clinical relevance in improving the accuracy of sampling during microlaryngeal surgery. Optical coherence tomography (OCT) is an optical imaging technique that clearly identifies basement membrane violation caused by laryngeal cancer. With a microscope-based spectral domain OCT (SD-OCT) we reached in vivo a fairly accurate assessment of benign and dysplastic laryngeal lesions. Recent improvements in OCT technology have led to the development of high-speed OCT systems displaying millions of pixels per second. These systems allow non-contact real-time imaging of large sections of laryngeal tissue. Polarization contrast OCT (PS-OCT) may provide additional information about the lamina propria of the true vocal cord because of the birefringence of connective tissue. We present microscope-based high-speed SD-OCT images with and without polarization contrast and 3D volumes of selected laryngeal pathologies in order to demonstrate our current concepts for the intended intraoperative application. High-speed SD-OCT and polarization contrast can also be complemented by our recently developed rigid confocal endoscopic system to obtain cellular and sub-cellular information about the tissue. Further perspectives will be presented.

PET/MR in oncology: an introduction with focus on MR and future perspectives for hybrid imaging

PubMed Central

Balyasnikova, Svetlana; Löfgren, Johan; de Nijs, Robin; Zamogilnaya, Yanna; Højgaard, Liselotte; Fischer, Barbara M

2012-01-01

After more than 20 years of research, a fully integrated PET/MR scanner was launched in 2010 enabling simultaneous acquisition of PET and MR imaging. Currently, no clinical indication for combined PET/MR has been established, however the expectations are high. In this paper we will discuss some of the challenges inherent in this new technology, but focus on potential applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to most readers of this journal; thus this paper aims to provide a short and basic introduction to a number of different MRI techniques, such as DWI-MR (diffusion weighted imaging MR), DCE-MR (dynamic contrast enhanced MR), MRS (MR spectroscopy) and MR for attenuation correction of PET. All MR techniques presented in this paper have shown promising results in the treatment of patients with solid tumors and could be applied together with PET increasing the amount of information about the tissues of interest. The potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the research perspectives for the use of PET/MR in the development of new tracers and drugs will be discussed. PMID:23145362

The need for supplemental breast cancer screening modalities: a perspective of population-based breast cancer screening programs in Japan.

PubMed

Uematsu, Takayoshi

2017-01-01

This article discusses possible supplemental breast cancer screening modalities for younger women with dense breasts from a perspective of population-based breast cancer screening program in Japan. Supplemental breast cancer screening modalities have been proposed to increase the sensitivity and detection rates of early stage breast cancer in women with dense breasts; however, there are no global guidelines that recommend the use of supplemental breast cancer screening modalities in such women. Also, no criterion standard exists for breast density assessment. Based on the current situation of breast imaging in Japan, the possible supplemental breast cancer screening modalities are ultrasonography, digital breast tomosynthesis, and breast magnetic resonance imaging. An appropriate population-based breast cancer screening program based on the balance between cost and benefit should be a high priority. Further research based on evidence-based medicine is encouraged. It is very important that the ethnicity, workforce, workflow, and resources for breast cancer screening in each country should be considered when considering supplemental breast cancer screening modalities for women with dense breasts.

Medical image computing for computer-supported diagnostics and therapy. Advances and perspectives.

PubMed

Handels, H; Ehrhardt, J

2009-01-01

Medical image computing has become one of the most challenging fields in medical informatics. In image-based diagnostics of the future software assistance will become more and more important, and image analysis systems integrating advanced image computing methods are needed to extract quantitative image parameters to characterize the state and changes of image structures of interest (e.g. tumors, organs, vessels, bones etc.) in a reproducible and objective way. Furthermore, in the field of software-assisted and navigated surgery medical image computing methods play a key role and have opened up new perspectives for patient treatment. However, further developments are needed to increase the grade of automation, accuracy, reproducibility and robustness. Moreover, the systems developed have to be integrated into the clinical workflow. For the development of advanced image computing systems methods of different scientific fields have to be adapted and used in combination. The principal methodologies in medical image computing are the following: image segmentation, image registration, image analysis for quantification and computer assisted image interpretation, modeling and simulation as well as visualization and virtual reality. Especially, model-based image computing techniques open up new perspectives for prediction of organ changes and risk analysis of patients and will gain importance in diagnostic and therapy of the future. From a methodical point of view the authors identify the following future trends and perspectives in medical image computing: development of optimized application-specific systems and integration into the clinical workflow, enhanced computational models for image analysis and virtual reality training systems, integration of different image computing methods, further integration of multimodal image data and biosignals and advanced methods for 4D medical image computing. The development of image analysis systems for diagnostic support or operation planning is a complex interdisciplinary process. Image computing methods enable new insights into the patient's image data and have the future potential to improve medical diagnostics and patient treatment.

Not all memories are the same: Situational context influences spatial recall within one's city of residency.

PubMed

Meilinger, Tobias; Frankenstein, Julia; Simon, Nadine; Bülthoff, Heinrich H; Bresciani, Jean-Pierre

2016-02-01

Reference frames in spatial memory encoding have been examined intensively in recent years. However, their importance for recall has received considerably less attention. In the present study, passersby used tags to arrange a configuration map of prominent city center landmarks. It has been shown that such configurational knowledge is memorized within a north-up reference frame. However, participants adjusted their maps according to their body orientations. For example, when participants faced south, the maps were likely to face south-up. Participants also constructed maps along their location perspective-that is, the self-target direction. If, for instance, they were east of the represented area, their maps were oriented west-up. If the location perspective and body orientation were in opposite directions (i.e., if participants faced away from the city center), participants relied on location perspective. The results indicate that reference frames in spatial recall depend on the current situation rather than on the organization in long-term memory. These results cannot be explained by activation spread within a view graph, which had been used to explain similar results in the recall of city plazas. However, the results are consistent with forming and transforming a spatial image of nonvisible city locations from the current location. Furthermore, prior research has almost exclusively focused on body- and environment-based reference frames. The strong influence of location perspective in an everyday navigational context indicates that such a reference frame should be considered more often when examining human spatial cognition.

ARC-1994-AC94-0353-2

NASA Image and Video Library

1994-07-01

Photo Artwork composite by JPL This depiction of comet Shoemaker-Levy 9 impacting Jupiter is shown from several perspectives. IMAGE A is shown from the perspective of Earth based observers. IMAGE B shows the perspective from Galileo spacecraft which can observe the impact point directly. IMAGE C is shown from the Voyager 2 spacecraft, which may observe the event from its unique position at the outer reaches of the solar system. IMAGE D depicts a generic view from Jupiter's south pole. For visual appeal, most of the large cometary fragments are shown close to one another in this image. At the time of Jupiter impact, the fragments will be separated from one another by serveral times the distances shown. This image was created by D.A. Seal of JPL's Mission Design Section using orbital computations provIded by P.W. Chodas and D.K. Yeomans of JPL's Navigation Section.

Optimization of exposure index values for the antero-posterior pelvis and antero-posterior knee examination

NASA Astrophysics Data System (ADS)

Butler, M. L.; Rainford, L.; Last, J.; Brennan, P. C.

2009-02-01

Introduction The American Association of Medical Physicists is currently standardizing the exposure index (EI) value. Recent studies have questioned whether the EI value offered by manufacturers is optimal. This current work establishes optimum EIs for the antero-posterior (AP) projections of a pelvis and knee on a Carestream Health (Kodak) CR system and compares these with manufacturers recommended EI values from a patient dose and image quality perspective. Methodology Human cadavers were used to produce images of clinically relevant standards. Several exposures were taken to achieve various EI values and corresponding entrance surface doses (ESD) were measured using thermoluminescent dosimeters. Image quality was assessed by 5 experienced clinicians using anatomical criteria judged against a reference image. Visualization of image specific common abnormalities was also analyzed to establish diagnostic efficacy. Results A rise in ESD for both examinations, consistent with increasing EI was shown. Anatomic image quality was deemed to be acceptable at an EI of 1560 for the AP pelvis and 1590 for the AP knee. From manufacturers recommended values, a significant reduction in ESD (p=0.02) of 38% and 33% for the pelvis and knee respectively was noted. Initial pathological analysis suggests that diagnostic efficacy at lower EI values may be projection-specific. Conclusion The data in this study emphasize the need for clinical centres to consider establishing their own EI guidelines, and not necessarily relying on manufacturers recommendations. Normal and abnormal images must be used in this process.

Mobile-based text recognition from water quality devices

NASA Astrophysics Data System (ADS)

Dhakal, Shanti; Rahnemoonfar, Maryam

2015-03-01

Measuring water quality of bays, estuaries, and gulfs is a complicated and time-consuming process. YSI Sonde is an instrument used to measure water quality parameters such as pH, temperature, salinity, and dissolved oxygen. This instrument is taken to water bodies in a boat trip and researchers note down different parameters displayed by the instrument's display monitor. In this project, a mobile application is developed for Android platform that allows a user to take a picture of the YSI Sonde monitor, extract text from the image and store it in a file on the phone. The image captured by the application is first processed to remove perspective distortion. Probabilistic Hough line transform is used to identify lines in the image and the corner of the image is then obtained by determining the intersection of the detected horizontal and vertical lines. The image is warped using the perspective transformation matrix, obtained from the corner points of the source image and the destination image, hence, removing the perspective distortion. Mathematical morphology operation, black-hat is used to correct the shading of the image. The image is binarized using Otsu's binarization technique and is then passed to the Optical Character Recognition (OCR) software for character recognition. The extracted information is stored in a file on the phone and can be retrieved later for analysis. The algorithm was tested on 60 different images of YSI Sonde with different perspective features and shading. Experimental results, in comparison to ground-truth results, demonstrate the effectiveness of the proposed method.

The Holistic Processing Account of Visual Expertise in Medical Image Perception: A Review

PubMed Central

Sheridan, Heather; Reingold, Eyal M.

2017-01-01

In the field of medical image perception, the holistic processing perspective contends that experts can rapidly extract global information about the image, which can be used to guide their subsequent search of the image (Swensson, 1980; Nodine and Kundel, 1987; Kundel et al., 2007). In this review, we discuss the empirical evidence supporting three different predictions that can be derived from the holistic processing perspective: Expertise in medical image perception is domain-specific, experts use parafoveal and/or peripheral vision to process large regions of the image in parallel, and experts benefit from a rapid initial glimpse of an image. In addition, we discuss a pivotal recent study (Litchfield and Donovan, 2016) that seems to contradict the assumption that experts benefit from a rapid initial glimpse of the image. To reconcile this finding with the existing literature, we suggest that global processing may serve multiple functions that extend beyond the initial glimpse of the image. Finally, we discuss future research directions, and we highlight the connections between the holistic processing account and similar theoretical perspectives and findings from other domains of visual expertise. PMID:29033865

The Holistic Processing Account of Visual Expertise in Medical Image Perception: A Review.

PubMed

Sheridan, Heather; Reingold, Eyal M

2017-01-01

In the field of medical image perception, the holistic processing perspective contends that experts can rapidly extract global information about the image, which can be used to guide their subsequent search of the image (Swensson, 1980; Nodine and Kundel, 1987; Kundel et al., 2007). In this review, we discuss the empirical evidence supporting three different predictions that can be derived from the holistic processing perspective: Expertise in medical image perception is domain-specific, experts use parafoveal and/or peripheral vision to process large regions of the image in parallel, and experts benefit from a rapid initial glimpse of an image. In addition, we discuss a pivotal recent study (Litchfield and Donovan, 2016) that seems to contradict the assumption that experts benefit from a rapid initial glimpse of the image. To reconcile this finding with the existing literature, we suggest that global processing may serve multiple functions that extend beyond the initial glimpse of the image. Finally, we discuss future research directions, and we highlight the connections between the holistic processing account and similar theoretical perspectives and findings from other domains of visual expertise.

The role of ultrasound elastographic techniques in chronic liver disease: current status and future perspectives.

PubMed

Piscaglia, Fabio; Marinelli, Sara; Bota, Simona; Serra, Carla; Venerandi, Laura; Leoni, Simona; Salvatore, Veronica

2014-03-01

This review illustrates the state of the art clinical applications and the future perspectives of ultrasound elastographic methods for the evaluation of chronic liver diseases, including the most widely used and validated technique, transient elastography, followed by shear wave elastography and strain imaging elastography. Liver ultrasound elastography allows the non-invasive evaluation of liver stiffness, providing information regarding the stage of fibrosis, comparable to liver biopsy which is still considered the gold standard; in this way, it can help physicians in managing patients, including the decision as to when to start antiviral treatment. The characterization of focal liver lesions and the prognostic role of the elastographic technique in the prediction of complications of cirrhosis are still under investigation. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

The Response of the Ionospheric Cusp to the Solar Wind Through Two Perspectives: Low Energy Charged Particle In-Situ Measurements and Low-Energy Neutral Atom Imaging

NASA Technical Reports Server (NTRS)

Coffey, V. N.; Moore, T. E.; Chandler, M. O.; Giles, B. L.; Craven, P. D.; Rose, M. Franklin (Technical Monitor)

2000-01-01

The Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) mission provides a new perspective on the study of the response of the magnetosphere/ionosphere system to changing solar wind conditions, particularly the variability of ion outflow. Learning to interpret this new type of data becomes an essential step in the process of melding these results with the wealth of in-situ charged particle observations obtained over the past 25 years. In order to understand how the in-situ data correspond to and contrast with IMAGE results we will perform a conjunctive study of event data from two instruments to shed light on the coupling of the solar wind and ionosphere from these different perspectives. We will use the Low Energy Neutral Atom instrument (LENA) which images energetic neutral atom emissions from upward flowing ionospheric ions and the Thermal Ion Dynamics Instrument (TIDE) on the Polar satellite which measures in-situ ion outflow from 0.3-300 eV. Our primary goal will be to understand how comparing the imaging and in-situ perspectives can aid in the analysis of both data sets.

Rhinoceros Feet Step Out of a Rule-of-Thumb: A Wildlife Imaging Pioneering Approach of Synchronized Computed Tomography-Digital Radiography

PubMed Central

Saragusty, Joseph; Göritz, Frank; Potier, Romain; Mulot, Baptiste; Maillot, Alexis; Etienne, Pascal; Bernardino, Rui; Fernandes, Teresa; Mews, Jurgen; Hildebrandt, Thomas Bernd

2014-01-01

Currently, radiography is the only imaging technique used to diagnose bone pathology in wild animals situated under “field conditions”. Nevertheless, while chronic foot disease in captive mega-herbivores is widely reported, foot radiographic imaging is confronted with scarcity of studies. Numerous hindrances lead to such limited numbers and it became very clear that the traditional perspective on bone imaging in domestic animals based on extensive studies and elaborated statistical evaluations cannot be extrapolated to their non-domestic relatives. For these reasons, the authors initiated a multi-modality imaging study and established a pioneering approach of synchronized computed tomography (CT) and digital radiography (DR), based on X-ray projections derived from three-dimensional CT reconstructed images. Whereas this approach can be applied in any clinical field, as a case of outstanding importance and great concern for zoological institutions, we selected foot bone pathologies in captive rhinoceroses to demonstrate the manifold applications of the method. Several advances were achieved, endowing the wildlife clinician with all-important tools: prototype DR exposure protocols and a modus operandi for foot positioning, advancing both traditional projections and, for the first-time, species-related radiographic views; assessment of radiographic diagnostic value for the whole foot and, in premiere, for each autopodial bone; together with additional insights into radiographic appearance of bone anatomy and pathology with a unique, simultaneous CT-DR correlation. Based on its main advantages in availing a wide range of keystone data in wildlife imaging from a limited number of examined subjects and combining advantages of CT as the golden standard method for bone diseases' diagnostic with DR's clinical feasibility under field conditions, synchronized CT-DR presents a new perspective on wildlife's health management. With this we hope to provide veterinary clinicians with concrete imaging techniques and substantial diagnostic tools, which facilitate straightforward attainment and interpretation of field radiography images taken worldwide. PMID:24963807

Rhinoceros feet step out of a rule-of-thumb: a wildlife imaging pioneering approach of synchronized computed tomography-digital radiography.

PubMed

Galateanu, Gabriela; Hermes, Robert; Saragusty, Joseph; Göritz, Frank; Potier, Romain; Mulot, Baptiste; Maillot, Alexis; Etienne, Pascal; Bernardino, Rui; Fernandes, Teresa; Mews, Jurgen; Hildebrandt, Thomas Bernd

2014-01-01

Currently, radiography is the only imaging technique used to diagnose bone pathology in wild animals situated under "field conditions". Nevertheless, while chronic foot disease in captive mega-herbivores is widely reported, foot radiographic imaging is confronted with scarcity of studies. Numerous hindrances lead to such limited numbers and it became very clear that the traditional perspective on bone imaging in domestic animals based on extensive studies and elaborated statistical evaluations cannot be extrapolated to their non-domestic relatives. For these reasons, the authors initiated a multi-modality imaging study and established a pioneering approach of synchronized computed tomography (CT) and digital radiography (DR), based on X-ray projections derived from three-dimensional CT reconstructed images. Whereas this approach can be applied in any clinical field, as a case of outstanding importance and great concern for zoological institutions, we selected foot bone pathologies in captive rhinoceroses to demonstrate the manifold applications of the method. Several advances were achieved, endowing the wildlife clinician with all-important tools: prototype DR exposure protocols and a modus operandi for foot positioning, advancing both traditional projections and, for the first-time, species-related radiographic views; assessment of radiographic diagnostic value for the whole foot and, in premiere, for each autopodial bone; together with additional insights into radiographic appearance of bone anatomy and pathology with a unique, simultaneous CT-DR correlation. Based on its main advantages in availing a wide range of keystone data in wildlife imaging from a limited number of examined subjects and combining advantages of CT as the golden standard method for bone diseases' diagnostic with DR's clinical feasibility under field conditions, synchronized CT-DR presents a new perspective on wildlife's health management. With this we hope to provide veterinary clinicians with concrete imaging techniques and substantial diagnostic tools, which facilitate straightforward attainment and interpretation of field radiography images taken worldwide.

TU-C-201-01: Clinical Implementation of HDR: A New User’s Perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Hallaq, H.

2015-06-15

Recent use of HDR has increased while planning has become more complex often necessitating 3D image-based planning. While many guidelines for the use of HDR exist, they have not kept pace with the increased complexity of 3D image-based planning. Furthermore, no comprehensive document exists to describe the wide variety of current HDR clinical indications. This educational session aims to summarize existing national and international guidelines for the safe implementation of an HDR program. A summary of HDR afterloaders available on the market and their existing applicators will be provided, with guidance on how to select the best fit for eachmore » institution’s needs. Finally, the use of checklists will be discussed as a means to implement a safe and efficient HDR program and as a method by which to verify the quality of an existing HDR program. This session will provide the perspective of expert HDR physicists as well as the perspective of a new HDR user. Learning Objectives: Summarize national and international safety and staffing guidelines for HDR implementation Discuss the process of afterloader and applicator selection for gynecologic, prostate, breast, interstitial, surface treatments Learn about the use of an audit checklist tool to measure of quality control of a new or existing HDR program Describe the evolving use of checklists within an HDR program.« less

Meteorological data fields 'in perspective'

NASA Technical Reports Server (NTRS)

Hasler, A. F.; Pierce, H.; Morris, K. R.; Dodge, J.

1985-01-01

Perspective display techniques can be applied to meteorological data sets to aid in their interpretation. Examples of a perspective display procedure applied to satellite and aircraft visible and infrared image pairs and to stereo cloud-top height analyses are presented. The procedure uses a sophisticated shading algorithm that produces perspective images with greatly improved comprehensibility when compared with the wire-frame perspective displays that have been used in the past. By changing the 'eye-point' and 'view-point' inputs to the program in a systematic way, movie loops that give the impression of flying over or through the data field have been made. This paper gives examples that show how several kinds of meteorological data fields are more effectively illustrated using the perspective technique.

Analyzing prospective teachers' images of scientists using positive, negative and stereotypical images of scientists

NASA Astrophysics Data System (ADS)

Subramaniam, Karthigeyan; Esprívalo Harrell, Pamela; Wojnowski, David

2013-04-01

Background and purpose : This study details the use of a conceptual framework to analyze prospective teachers' images of scientists to reveal their context-specific conceptions of scientists. The conceptual framework consists of context-specific conceptions related to positive, stereotypical and negative images of scientists as detailed in the literature on the images, role and work of scientists. Sample, design and method : One hundred and ninety-six drawings of scientists, generated by prospective teachers, were analyzed using the Draw-A-Scientist-Test Checklist (DAST-C), a binary linear regression and the conceptual framework. Results : The results of the binary linear regression analysis revealed a statistically significant difference for two DAST-C elements: ethnicity differences with regard to drawing a scientist who was Caucasian and gender differences for indications of danger. Analysis using the conceptual framework helped to categorize the same drawings into positive, stereotypical, negative and composite images of a scientist. Conclusions : The conceptual framework revealed that drawings were focused on the physical appearance of the scientist, and to a lesser extent on the equipment, location and science-related practices that provided the context of a scientist's role and work. Implications for teacher educators include the need to understand that there is a need to provide tools, like the conceptual framework used in this study, to help prospective teachers to confront and engage with their multidimensional perspectives of scientists in light of the current trends on perceiving and valuing scientists. In addition, teacher educators need to use the conceptual framework, which yields qualitative perspectives about drawings, together with the DAST-C, which yields quantitative measure for drawings, to help prospective teachers to gain a holistic outlook on their drawings of scientists.

Utilizing virtual and augmented reality for educational and clinical enhancements in neurosurgery.

PubMed

Pelargos, Panayiotis E; Nagasawa, Daniel T; Lagman, Carlito; Tenn, Stephen; Demos, Joanna V; Lee, Seung J; Bui, Timothy T; Barnette, Natalie E; Bhatt, Nikhilesh S; Ung, Nolan; Bari, Ausaf; Martin, Neil A; Yang, Isaac

2017-01-01

Neurosurgery has undergone a technological revolution over the past several decades, from trephination to image-guided navigation. Advancements in virtual reality (VR) and augmented reality (AR) represent some of the newest modalities being integrated into neurosurgical practice and resident education. In this review, we present a historical perspective of the development of VR and AR technologies, analyze its current uses, and discuss its emerging applications in the field of neurosurgery. Copyright © 2016 Elsevier Ltd. All rights reserved.

150 years of Sigmund Freud: What would Freud have said about the obesity epidemic?

PubMed

Bornstein, S R; Wong, M-L; Licinio, J

2006-12-01

The 150th birthday of Sigmund Freud has triggered widespread interest and media coverage on his unique contribution and impact on society. Recent evidence from neuroscience and advanced imaging technology has provided support for some of his major concepts including the unconscious and the key role of early life events. In this perspective, we attempt to write on his behalf an updated version of a Freudian way of thinking focused on the current high rates of obesity and depression.

The Focusing Optics X-ray Solar Imager Small Explorer Concept Mission

NASA Astrophysics Data System (ADS)

Christe, Steven; Shih, Albert Y.; Dennis, Brian R.; Glesener, Lindsay; Krucker, Sam; Saint-Hilaire, Pascal; Gubarev, Mikhail; Ramsey, Brian

2016-05-01

We present the FOXSI (Focusing Optics X-ray Solar Imager) small explorer (SMEX) concept, a mission dedicated to studying particle acceleration and energy release on the Sun. FOXSI is designed as a 3-axis stabilized spacecraft in low-Earth orbit making use of state-of-the-art grazing incidence focusing optics combined withpixelated solid-state detectors, allowing for direct imaging of solar X-rays. The current design being studied features multiple telescopes with a 14 meter focal length enabled by a deployable boom.FOXSI will observe the Sun in the 3-100 keV energy range. The FOXSI imaging concept has already been tested on two sounding rocket flights, in 2012 and 2014 and on the HEROES balloon payload flight in 2013. FOXSI will image the Sun with an angular resolution of 5'', a spectral resolution of 0.5 keV, and sub-second temporal resolution. FOXSI is a direct imaging spectrometer with high dynamic range and sensitivity and will provide a brand-new perspective on energy release on the Sun. We describe the mission and its science objectives.

Indocyanine green fluorescence imaging in the surgical management of liver cancers: current facts and future implications.

PubMed

Lim, C; Vibert, E; Azoulay, D; Salloum, C; Ishizawa, T; Yoshioka, R; Mise, Y; Sakamoto, Y; Aoki, T; Sugawara, Y; Hasegawa, K; Kokudo, N

2014-04-01

Imaging detection of liver cancers and identification of the bile ducts during surgery, based on the fluorescence properties of indocyanine green, has recently been developed in liver surgery. The principle of this imaging technique relies on the intravenous administration of indocyanine green before surgery and the illumination of the surface of the liver by an infrared camera that simultaneously induces and collects the fluorescence. Detection by fluorescence is based on the contrast between the (fluorescent) tumoral or peri-tumoral tissues and the healthy (non-fluorescent) liver. Results suggest that indocyanine green fluorescence imaging is capable of identification of new liver cancers and enables the characterization of known hepatic lesions in real time during liver resection. The purpose of this paper is to present the fundamental principles of fluorescence imaging detection, to describe successively the practical and technical aspects of its use and the appearance of hepatic lesions in fluorescence, and to expose the diagnostic and therapeutic perspectives of this innovative imaging technique in liver surgery. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Goal-oriented rectification of camera-based document images.

PubMed

Stamatopoulos, Nikolaos; Gatos, Basilis; Pratikakis, Ioannis; Perantonis, Stavros J

2011-04-01

Document digitization with either flatbed scanners or camera-based systems results in document images which often suffer from warping and perspective distortions that deteriorate the performance of current OCR approaches. In this paper, we present a goal-oriented rectification methodology to compensate for undesirable document image distortions aiming to improve the OCR result. Our approach relies upon a coarse-to-fine strategy. First, a coarse rectification is accomplished with the aid of a computationally low cost transformation which addresses the projection of a curved surface to a 2-D rectangular area. The projection of the curved surface on the plane is guided only by the textual content's appearance in the document image while incorporating a transformation which does not depend on specific model primitives or camera setup parameters. Second, pose normalization is applied on the word level aiming to restore all the local distortions of the document image. Experimental results on various document images with a variety of distortions demonstrate the robustness and effectiveness of the proposed rectification methodology using a consistent evaluation methodology that encounters OCR accuracy and a newly introduced measure using a semi-automatic procedure.

Landslides in a Charon Chasm

NASA Image and Video Library

2016-10-18

perspective view of Charon's informally named "Serenity Chasm" consists of topography generated from stereo reconstruction of images taken by New Horizons' Long Range Reconnaissance Imager (LORRI) and Multispectral Visible Imaging Camera (MVIC), supplemented by a "shape-from-shading" algorithm. The topography is then overlain with the PIA21128 image mosaic and the perspective view is rendered. The MVIC image was taken from a distance of 45,458 miles (73,159 kilometers) while the LORRI picture was taken from 19,511 miles (31,401 kilometers) away, both on July 14, 2015. http://photojournal.jpl.nasa.gov/catalog/PIA21129

Time perspective and positivity effects in Alzheimer's disease.

PubMed

Bohn, Linzy; Kwong See, Sheree T; Fung, Helene H

2016-09-01

This study tested whether time perspective, a central tenant of socioemotional selectivity theory (Carstensen, 2006), moderates positivity effects in emotional memory. To provide measures of time perspective, young (YA; M = 22.48 years), young-old (YO; M = 67.56 years), old-old adults (OO; M = 80.24 years), and participants with moderate severity Alzheimer's disease (PAD; M = 84.28 years) completed a line task and reported subjective age. As expected, YA, YO, and OO reported successively more constrained future time perspectives. PAD showed distortion in time perspective, envisioning a future comparable with the YO, although closer matched in chronological age to OO adults. To evince positivity effects, participants were oriented to pairs of emotional images and were then tested for memory (recall and recognition) of the images. Recall and recognition memory for the images indicated an age-related advantage for positive over negative material (positivity effects). Time perspective, however, did not moderate these age effects. In memory performance, PAD were more comparable with OO adults with whom they shared a similar chronological age, rather than YO adults, who had a corresponding time perspective. These results suggest that age correlates that are shared by PAD and OO, such as reduced processing resources, rather than time perspective, may drive the age associated positivity effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Weight status and body image perceptions in adolescents: current perspectives.

PubMed

Voelker, Dana K; Reel, Justine J; Greenleaf, Christy

2015-01-01

Adolescence represents a pivotal stage in the development of positive or negative body image. Many influences exist during the teen years including transitions (eg, puberty) that affect one's body shape, weight status, and appearance. Weight status exists along a spectrum between being obese (ie, where one's body weight is in the 95th percentile for age and gender) to being underweight. Salient influences on body image include the media, which can target adolescents, and peers who help shape beliefs about the perceived body ideal. Internalization of and pressures to conform to these socially prescribed body ideals help to explain associations between weight status and body image. The concepts of fat talk and weight-related bullying during adolescence greatly contribute to an overemphasis on body weight and appearance as well as the development of negative body perceptions and dissatisfaction surrounding specific body parts. This article provides an overview of the significance of adolescent development in shaping body image, the relationship between body image and adolescent weight status, and the consequences of having a negative body image during adolescence (ie, disordered eating, eating disorders, and dysfunctional exercise). Practical implications for promoting a healthy weight status and positive body image among adolescents will be discussed.

Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective.

PubMed

Lee, Anne W M; Ma, Brigette B Y; Ng, Wai Tong; Chan, Anthony T C

2015-10-10

Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. Advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngeal carcinoma as well as its etiologic association with the Epstein-Barr virus. This in turn has led to the discovery of novel biomarkers and drug targets, rendering this cancer site a current focus for new drug development. This article reviews and appraises the key literature on the current management of nasopharyngeal carcinoma and future directions in clinical research. © 2015 by American Society of Clinical Oncology.

Capabilities of a FOXSI Small Explorer

NASA Astrophysics Data System (ADS)

Inglis, A. R.; Christe, S.; Glesener, L.; Krucker, S.; Dennis, B. R.; Shih, A.; Wilson-Hodge, C.; Gubarev, M.; Hudson, H. S.; Kontar, E.; Buitrago Casas, J. C.; Drake, J. F.; Caspi, A.; Holman, G.; Allred, J. C.; Ryan, D.; Alaoui, M.; White, S. M.; Saint-Hilaire, P.; Klimchuk, J. A.; Hannah, I. G.; Antiochos, S. K.; Grefenstette, B.; Ramsey, B.; Jeffrey, N. L. S.; Reep, J. W.; Schwartz, R. A.; Ireland, J.

2015-12-01

We present the FOXSI (Focusing Optics X-ray Solar Imager) small explorer (SMEX) concept, a mission dedicated to studying particle acceleration and energy release on the Sun. FOXSI is designed as a 3-axis stabilized spacecraft in low-Earth orbit making use of state-of-the-art grazing incidence focusing optics, allowing for direct imaging of solar X-rays. The current design being studied features three telescope modules deployed in a low-inclination low-earth orbit (LEO). With a 15 meter focal length enabled by a deployable boom, FOXSI will observe the Sun in the 3-50 keV energe range. The FOXSI imaging concept has already been tested on two sounding rocket flights, in 2012 and 2014 and on the HEROES balloon payload flight in 2013. FOXSI will image the Sun with an angular resolution of 5'', a spectral resolution of 0.5 keV, and sub-second temporal resolution using CdTe detectors. In this presentation we investigate the science objectives and targets which can be accessed from this mission. Because of the defining characteristic of FOXSI is true imaging spectroscopy with high dynamic range and sensitivity, a brand-new perspective on energy release on the Sun is possible. Some of the science targets discussed here include; flare particle acceleration processes, electron beams, return currents, sources of solar energetic particles (SEPs), as well as understanding X-ray emission from active region structures and the quiescent corona.

Parallel image reconstruction for 3D positron emission tomography from incomplete 2D projection data

NASA Astrophysics Data System (ADS)

Guerrero, Thomas M.; Ricci, Anthony R.; Dahlbom, Magnus; Cherry, Simon R.; Hoffman, Edward T.

1993-07-01

The problem of excessive computational time in 3D Positron Emission Tomography (3D PET) reconstruction is defined, and we present an approach for solving this problem through the construction of an inexpensive parallel processing system and the adoption of the FAVOR algorithm. Currently, the 3D reconstruction of the 610 images of a total body procedure would require 80 hours and the 3D reconstruction of the 620 images of a dynamic study would require 110 hours. An inexpensive parallel processing system for 3D PET reconstruction is constructed from the integration of board level products from multiple vendors. The system achieves its computational performance through the use of 6U VME four i860 processor boards, the processor boards from five manufacturers are discussed from our perspective. The new 3D PET reconstruction algorithm FAVOR, FAst VOlume Reconstructor, that promises a substantial speed improvement is adopted. Preliminary results from parallelizing FAVOR are utilized in formulating architectural improvements for this problem. In summary, we are addressing the problem of excessive computational time in 3D PET image reconstruction, through the construction of an inexpensive parallel processing system and the parallelization of a 3D reconstruction algorithm that uses the incomplete data set that is produced by current PET systems.

New perspective of undeployed rover

NASA Technical Reports Server (NTRS)

1997-01-01

This image features a different perspective of one of the first pictures taken by the Imager for Mars Pathfinder (IMP) lander shortly after its touchdown at 10:07 AM Pacific Daylight Time on July 4. The image has been transformed to a perspective that would match that of an observer standing at the point the image was taken. Sojourner is seen in the foreground in its stowed position on a solar panel of the lander. Both ramps, the rear of which Sojourner would use on July 5 to safely descend to the Martian surface, were still undeployed when this image was taken. The double hills called 'Twin Peaks' are clearly visible in the background.

The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

Table-driven image transformation engine algorithm

NASA Astrophysics Data System (ADS)

Shichman, Marc

1993-04-01

A high speed image transformation engine (ITE) was designed and a prototype built for use in a generic electronic light table and image perspective transformation application code. The ITE takes any linear transformation, breaks the transformation into two passes and resamples the image appropriately for each pass. The system performance is achieved by driving the engine with a set of look up tables computed at start up time for the calculation of pixel output contributions. Anti-aliasing is done automatically in the image resampling process. Operations such as multiplications and trigonometric functions are minimized. This algorithm can be used for texture mapping, image perspective transformation, electronic light table, and virtual reality.

Tumor Immunotargeting Using Innovative Radionuclides

PubMed Central

Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

2015-01-01

This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

Deep Learning in Medical Imaging: General Overview

PubMed Central

Lee, June-Goo; Jun, Sanghoon; Cho, Young-Won; Lee, Hyunna; Kim, Guk Bae

2017-01-01

The artificial neural network (ANN)–a machine learning technique inspired by the human neuronal synapse system–was introduced in the 1950s. However, the ANN was previously limited in its ability to solve actual problems, due to the vanishing gradient and overfitting problems with training of deep architecture, lack of computing power, and primarily the absence of sufficient data to train the computer system. Interest in this concept has lately resurfaced, due to the availability of big data, enhanced computing power with the current graphics processing units, and novel algorithms to train the deep neural network. Recent studies on this technology suggest its potentially to perform better than humans in some visual and auditory recognition tasks, which may portend its applications in medicine and healthcare, especially in medical imaging, in the foreseeable future. This review article offers perspectives on the history, development, and applications of deep learning technology, particularly regarding its applications in medical imaging. PMID:28670152

Deep Learning in Medical Imaging: General Overview.

PubMed

Lee, June-Goo; Jun, Sanghoon; Cho, Young-Won; Lee, Hyunna; Kim, Guk Bae; Seo, Joon Beom; Kim, Namkug

2017-01-01

The artificial neural network (ANN)-a machine learning technique inspired by the human neuronal synapse system-was introduced in the 1950s. However, the ANN was previously limited in its ability to solve actual problems, due to the vanishing gradient and overfitting problems with training of deep architecture, lack of computing power, and primarily the absence of sufficient data to train the computer system. Interest in this concept has lately resurfaced, due to the availability of big data, enhanced computing power with the current graphics processing units, and novel algorithms to train the deep neural network. Recent studies on this technology suggest its potentially to perform better than humans in some visual and auditory recognition tasks, which may portend its applications in medicine and healthcare, especially in medical imaging, in the foreseeable future. This review article offers perspectives on the history, development, and applications of deep learning technology, particularly regarding its applications in medical imaging.

NanoSIMS for biological applications: Current practices and analyses

DOE PAGES

Nunez, Jamie R.; Renslow, Ryan S.; Cliff, III, John B.; ...

2017-09-27

Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in biologically-relevant studies. Of these, high lateral resolution methodologies using the NanoSIMS 50/50L have been especially powerful within many biological fields over the past decade. Here, we provide a review of this technology, sample preparation and analysis considerations, examples of recent biological studies, data analysis, and current outlooks. Specifically, we offer an overview of SIMS and development of the NanoSIMS. We describe the major experimental factors that should be considered prior to NanoSIMS analysis and then provide information on best practices for data analysis and image generation, which includesmore » an in-depth discussion of appropriate colormaps. Additionally, we provide an open-source method for data representation that allows simultaneous visualization of secondary electron and ion information within a single image. Lastly, we present a perspective on the future of this technology and where we think it will have the greatest impact in near future.« less

NanoSIMS for biological applications: Current practices and analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nunez, Jamie R.; Renslow, Ryan S.; Cliff, III, John B.

Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in biologically-relevant studies. Of these, high lateral resolution methodologies using the NanoSIMS 50/50L have been especially powerful within many biological fields over the past decade. Here, we provide a review of this technology, sample preparation and analysis considerations, examples of recent biological studies, data analysis, and current outlooks. Specifically, we offer an overview of SIMS and development of the NanoSIMS. We describe the major experimental factors that should be considered prior to NanoSIMS analysis and then provide information on best practices for data analysis and image generation, which includesmore » an in-depth discussion of appropriate colormaps. Additionally, we provide an open-source method for data representation that allows simultaneous visualization of secondary electron and ion information within a single image. Lastly, we present a perspective on the future of this technology and where we think it will have the greatest impact in near future.« less

Healthcare provider and patient perspectives on diagnostic imaging investigations.

PubMed

Makanjee, Chandra R; Bergh, Anne-Marie; Hoffmann, Willem A

2015-05-20

Much has been written about the patient-centred approach in doctor-patient consultations. Little is known about interactions and communication processes regarding healthcare providers' and patients' perspectives on expectations and experiences of diagnostic imaging investigations within the medical encounter. Patients journey through the health system from the point of referral to the imaging investigation itself and then to the post-imaging consultation. AIM AND SETTING: To explore healthcare provider and patient perspectives on interaction and communication processes during diagnostic imaging investigations as part of their clinical journey through a healthcare complex. A qualitative study was conducted, with two phases of data collection. Twenty-four patients were conveniently selected at a public district hospital complex and were followed throughout their journey in the hospital system, from admission to discharge. The second phase entailed focus group interviews conducted with providers in the district hospital and adjacent academic hospital (medical officers and family physicians, nurses, radiographers, radiology consultants and registrars). Two main themes guided our analysis: (1) provider perspectives; and (2) patient dispositions and reactions. Golden threads that cut across these themes are interactions and communication processes in the context of expectations, experiences of the imaging investigations and the outcomes thereof. Insights from this study provide a better understanding of the complexity of the processes and interactions between providers and patients during the imaging investigations conducted as part of their clinical pathway. The interactions and communication processes are provider-patient centred when a referral for a diagnostic imaging investigation is included.

Healthcare reform for imagers: finding a way forward now.

PubMed

Douglas, Pamela S; Picard, Michael H

2013-03-01

The changing healthcare environment presents many challenges to cardiovascular imagers. This perspective paper uses current trends to propose strategies that cardiovascular imagers can follow to lead in managing change and developing the imaging laboratory of the future. In the area of quality, imagers are encouraged to follow guidelines and standards, implement structured reporting and laboratory databases, adopt ongoing quality improvement programs, and use benchmarks to confirm imaging quality. In the area of access, imagers are encouraged to enhance availability of testing, focus on patient and referring physician value and satisfaction, collaboratively implement new technologies and uses of imaging, integrate health information technology in the laboratory, and work toward the appropriate inclusion of imaging in new healthcare delivery models. In the area of cost, imagers are encouraged to minimize laboratory operating expenses without compromising quality, and to take an active role in care redesign initiatives to ensure that imaging is utilized appropriately and at proper time intervals. Imagers are also encouraged to learn leadership and management skills, undertake strategic planning exercises, and build strong, collaborative teams. Although it is difficult to predict the future of cardiovascular imaging delivery, a reasonable sense of the likely direction of many changes and careful attention to the fundamentals of good health care (quality, access, and cost) can help imagers to thrive now and in the future. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

The Response of the Ionospheric Cusp to the Solar Through Two Perspectives: Low Energy Changed Particle In-Situ Measurements and Low- Energy Neutral Atom Imaging

NASA Technical Reports Server (NTRS)

Coffey, V. N.; Moore, T. E.; Chandler, M. O.; Craven, P. D.

2000-01-01

The IMAGE mission provides a new perspective on the study of the response of the magnetosphere/ionosphere system to changing solar wind conditions, particularly the variability of ion outflow. Learning to interpret this new type of data becomes an essential step in the process of melding these results with the wealth of in-situ charged particle observations obtained over the past 25 years. In order to understand how the in-situ data correspond to and contrast with IMAGE results we will perform a conjunctive study of event data from two instruments to shed light on the coupling of the solar wind and ionosphere from these different perspectives. We will use the Low Energy Neutral Atom instrument (LENA) which images energetic neutral atom emissions from upward flowing ionospheric ions and the Thermal Ion Dynamics Instrument (TIDE) on the Polar satellite which measures in-situ ion outflow from 0.3-300 eV. Our primary goal will be to understand how comparing the imaging and in-situ perspectives can aid in the analysis of both data sets.

[Perspectives on body: embodiment and body image].

PubMed

Chang, Shiow-Ru; Chao, Yu-Mei Yu

2007-06-01

"Body" is a basic concept of both the natural and human sciences. This extensive review of the literature explores the various philosophical approaches to the body, including empiricism, idealism, existentialism and phenomenology, as well as the relationship between body and mind. Embodiment and body image are the two main concepts of body addressed in this article. Merleau-Ponty's perspective on embodiment, an important new area of theory development, emphasizes that embodiment research must focus on life experiences, such as the study of body image. Using Schilder's framework of psychosocialology, this article provides a comprehensive understanding of the concept of body image and women's perspectives on the "body" in both Western culture and Eastern cultures. Body size and shape significantly influence the self-image of women. Body image is something that develops and changes throughout one's life span and is continually being constructed, destructed, and reconstructed. Personal body image has important psychological effects on the individual, especially women. This integrative review can make a significant contribution to knowledge in this area and, consequently, to related practice and research.

Plasmaspheric Plumes Observed by the CLUSTER and IMAGE Spacecraft

NASA Technical Reports Server (NTRS)

Fung, S. F.; Benson, R. F.; Garcia, L. N.; Adrian, M. L.; Sandel, B.; Goldstein, M. L.

2008-01-01

Global IMAGE/EUV observations have revealed complex changes in plasmaspheric structures as the plasmasphere responds to geomagnetic activity while remaining under varying degrees of influence by co-rotation, depending on the radial distance. The complex plasmaspheric dynamics, with different scales of variability, is clearly far from being well understood. There is now renewed interest in the plasmasphere due to its apparent connections with the development of the ring current and radiation belt, and loss of ionospheric plasmas. Early in the mission, the Cluster spacecraft only crossed the plasmapause (L - 4) occasionally and made measurements of the outer plasmasphere and plasmaspheric drainage plumes. The study by Darrouzet et al. [2006] provided detailed analyses of in situ Cluster observations and IMAGE EUV observations of three plasmaspheric plumes detected in April-June, 2002. Within the next couple of years, Cluster orbit will change, causing perigee to migrate to lower altitudes, and thus providing excellent opportunities to obtain more detailed measurements of the plasmasphere. In this paper, we report our analyses of the earlier Cluster-IMAGE events by incorporating the different perspectives provided by the IMAGE Radio Plasma Imager (RPI) observations. We will discuss our new understanding of the structure and dynamics of the Cluster-IMAGE events.

Neuromuscular imaging in inherited muscle diseases

PubMed Central

Kley, Rudolf A.; Fischer, Dirk

2010-01-01

Driven by increasing numbers of newly identified genetic defects and new insights into the field of inherited muscle diseases, neuromuscular imaging in general and magnetic resonance imaging (MRI) in particular are increasingly being used to characterise the severity and pattern of muscle involvement. Although muscle biopsy is still the gold standard for the establishment of the definitive diagnosis, muscular imaging is an important diagnostic tool for the detection and quantification of dystrophic changes during the clinical workup of patients with hereditary muscle diseases. MRI is frequently used to describe muscle involvement patterns, which aids in narrowing of the differential diagnosis and distinguishing between dystrophic and non-dystrophic diseases. Recent work has demonstrated the usefulness of muscle imaging for the detection of specific congenital myopathies, mainly for the identification of the underlying genetic defect in core and centronuclear myopathies. Muscle imaging demonstrates characteristic patterns, which can be helpful for the differentiation of individual limb girdle muscular dystrophies. The aim of this review is to give a comprehensive overview of current methods and applications as well as future perspectives in the field of neuromuscular imaging in inherited muscle diseases. We also provide diagnostic algorithms that might guide us through the differential diagnosis in hereditary myopathies. PMID:20422195

Resting-state functional magnetic resonance imaging in hepatic encephalopathy: current status and perspectives.

PubMed

Zhang, Long Jiang; Wu, Shengyong; Ren, Jiaqian; Lu, Guang Ming

2014-09-01

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as attention, working memory, and so on. Blood oxygen level dependent (BOLD) functional MRI (fMRI), especially resting-state fMRI has been used to explore the brain functional changes of HE, yielding important insights for understanding pathophysiological mechanisms and functional reorganization of HE. This paper briefly reviews the principles of BOLD fMRI, potential applications of resting-state fMRI with advanced post-processing algorithms such as regional homogeneity, amplitude of low frequency fluctuation, functional connectivity and future research perspective in this field.

Survey of contemporary trends in color image segmentation

NASA Astrophysics Data System (ADS)

Vantaram, Sreenath Rao; Saber, Eli

2012-10-01

In recent years, the acquisition of image and video information for processing, analysis, understanding, and exploitation of the underlying content in various applications, ranging from remote sensing to biomedical imaging, has grown at an unprecedented rate. Analysis by human observers is quite laborious, tiresome, and time consuming, if not infeasible, given the large and continuously rising volume of data. Hence the need for systems capable of automatically and effectively analyzing the aforementioned imagery for a variety of uses that span the spectrum from homeland security to elderly care. In order to achieve the above, tools such as image segmentation provide the appropriate foundation for expediting and improving the effectiveness of subsequent high-level tasks by providing a condensed and pertinent representation of image information. We provide a comprehensive survey of color image segmentation strategies adopted over the last decade, though notable contributions in the gray scale domain will also be discussed. Our taxonomy of segmentation techniques is sampled from a wide spectrum of spatially blind (or feature-based) approaches such as clustering and histogram thresholding as well as spatially guided (or spatial domain-based) methods such as region growing/splitting/merging, energy-driven parametric/geometric active contours, supervised/unsupervised graph cuts, and watersheds, to name a few. In addition, qualitative and quantitative results of prominent algorithms on several images from the Berkeley segmentation dataset are shown in order to furnish a fair indication of the current quality of the state of the art. Finally, we provide a brief discussion on our current perspective of the field as well as its associated future trends.

Biodegradable nanoparticles as theranostics of ovarian cancer: an overview.

PubMed

Chaurasiya, Swati; Mishra, Vijay

2018-04-01

Above 10 million people are suffering from cancers every year. As per American Cancer Society, more than 22 440 new cases and 14 080 deaths were reported from ovarian cancer yearly worldwide. This review explores the current status, challenges and future perspectives of tumour-targeted theranostic nanoparticles (NPs). Most of the ovarian malignancy cases are uncovered after the disease is in a difficult state due to poor screening techniques and non-specific symptoms. In this manner, forceful and fruitful treatment is required that will indicate insignificant lethal impacts to solid tissue. In the current research, stealth biodegradable NPs are produced as vehicles for imaging and treatment of ovarian cancer as the controlled and targeted delivery of chemotherapeutic as well as imaging agents. To enhance the dependability of the colloidal suspension as well as to increase their circulation lifetime, NPs are introduced by incorporating the functional poly(ethylene glycol) on their surface, which also provides a site to conjugation of focusing on agents to ovarian tissue. Biodegradable theranostic NPs can be fabricated and surface engineered without any alteration in drug-loading capacity, safety and efficacy. These NPs have shown promising results in imaging as well as treatment of ovarian cancer. © 2018 Royal Pharmaceutical Society.

A transformation-aware perceptual image metric

NASA Astrophysics Data System (ADS)

Kellnhofer, Petr; Ritschel, Tobias; Myszkowski, Karol; Seidel, Hans-Peter

2015-03-01

Predicting human visual perception has several applications such as compression, rendering, editing and retargeting. Current approaches however, ignore the fact that the human visual system compensates for geometric transformations, e. g., we see that an image and a rotated copy are identical. Instead, they will report a large, false-positive difference. At the same time, if the transformations become too strong or too spatially incoherent, comparing two images indeed gets increasingly difficult. Between these two extrema, we propose a system to quantify the effect of transformations, not only on the perception of image differences, but also on saliency. To this end, we first fit local homographies to a given optical flow field and then convert this field into a field of elementary transformations such as translation, rotation, scaling, and perspective. We conduct a perceptual experiment quantifying the increase of difficulty when compensating for elementary transformations. Transformation entropy is proposed as a novel measure of complexity in a flow field. This representation is then used for applications, such as comparison of non-aligned images, where transformations cause threshold elevation, and detection of salient transformations.

Comparing orbiter and rover image-based mapping of an ancient sedimentary environment, Aeolis Palus, Gale crater, Mars

NASA Astrophysics Data System (ADS)

Stack, K. M.; Edwards, C. S.; Grotzinger, J. P.; Gupta, S.; Sumner, D. Y.; Calef, F. J.; Edgar, L. A.; Edgett, K. S.; Fraeman, A. A.; Jacob, S. R.; Le Deit, L.; Lewis, K. W.; Rice, M. S.; Rubin, D.; Williams, R. M. E.; Williford, K. H.

2016-12-01

This study provides the first systematic comparison of orbital facies maps with detailed ground-based geology observations from the Mars Science Laboratory (MSL) Curiosity rover to examine the validity of geologic interpretations derived from orbital image data. Orbital facies maps were constructed for the Darwin, Cooperstown, and Kimberley waypoints visited by the Curiosity rover using High Resolution Imaging Science Experiment (HiRISE) images. These maps, which represent the most detailed orbital analysis of these areas to date, were compared with rover image-based geologic maps and stratigraphic columns derived from Curiosity's Mast Camera (Mastcam) and Mars Hand Lens Imager (MAHLI). Results show that bedrock outcrops can generally be distinguished from unconsolidated surficial deposits in high-resolution orbital images and that orbital facies mapping can be used to recognize geologic contacts between well-exposed bedrock units. However, process-based interpretations derived from orbital image mapping are difficult to infer without known regional context or observable paleogeomorphic indicators, and layer-cake models of stratigraphy derived from orbital maps oversimplify depositional relationships as revealed from a rover perspective. This study also shows that fine-scale orbital image-based mapping of current and future Mars landing sites is essential for optimizing the efficiency and science return of rover surface operations.

Comparing orbiter and rover image-based mapping of an ancient sedimentary environment, Aeolis Palus, Gale crater, Mars

USGS Publications Warehouse

Stack, Kathryn M.; Edwards, Christopher; Grotzinger, J. P.; Gupta, S.; Sumner, D.; Edgar, Lauren; Fraeman, A.; Jacob, S.; LeDeit, L.; Lewis, K.W.; Rice, M.S.; Rubin, D.; Calef, F.; Edgett, K.; Williams, R.M.E.; Williford, K.H.

2016-01-01

This study provides the first systematic comparison of orbital facies maps with detailed ground-based geology observations from the Mars Science Laboratory (MSL) Curiosity rover to examine the validity of geologic interpretations derived from orbital image data. Orbital facies maps were constructed for the Darwin, Cooperstown, and Kimberley waypoints visited by the Curiosity rover using High Resolution Imaging Science Experiment (HiRISE) images. These maps, which represent the most detailed orbital analysis of these areas to date, were compared with rover image-based geologic maps and stratigraphic columns derived from Curiosity’s Mast Camera (Mastcam) and Mars Hand Lens Imager (MAHLI). Results show that bedrock outcrops can generally be distinguished from unconsolidated surficial deposits in high-resolution orbital images and that orbital facies mapping can be used to recognize geologic contacts between well-exposed bedrock units. However, process-based interpretations derived from orbital image mapping are difficult to infer without known regional context or observable paleogeomorphic indicators, and layer-cake models of stratigraphy derived from orbital maps oversimplify depositional relationships as revealed from a rover perspective. This study also shows that fine-scale orbital image-based mapping of current and future Mars landing sites is essential for optimizing the efficiency and science return of rover surface operations.

77 FR 10756 - Proposed Collection; Comment Request; Opinions and Perspectives About the Current Blood Donation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... Request; Opinions and Perspectives About the Current Blood Donation Policy for Men Who Have Sex With Men... Collection: Title: Opinions and Perspectives about the Current Blood Donation Policy for Men Who Have Sex... current policy for blood donation in the U.S. with respect to men who have sex with men (MSM) is that any...

Looking Homeward Toward Earth: The Power of Perspective

NASA Astrophysics Data System (ADS)

Abdalati, W.

2012-08-01

With the 1968 "Earthrise" image of planet Earth emerging from beyond the lunar horizon, society's view of our celestial home was changed forever. Beautiful and vulnerable, and suspended in dark stillness, this image inspired an appreciation that we are one human race, whose fate hinges delicately on our collective actions. Since that time, space-based observations of the Earth have continued to provide essential insights and information across the full spectrum of human activities and natural processes, and have even become a mainstream part of our daily lives. From documenting disappearing Arctic ice cover, to providing key insights to hurricane evolution, to tracking the amount of movement and cycles of Earth's biomass, these observations allow us to understand how and why our world is changing, and what these changes mean for life on Earth. But beyond their tremendous scientific value, they can be a powerful and inspiring tool for generating a true appreciation of the complexities and beauty of the world in which we live. From that iconic Earthrise photograph to the viral popularity of event-based satellite imagery, the power of the space-based perspective satisfies our need for constant and current information, and fuels our emotional connection to the planet we call home.

In vivo miniature robots for natural orifice surgery: State of the art and future perspectives.

PubMed

Tiwari, Manish M; Reynoso, Jason F; Lehman, Amy C; Tsang, Albert W; Farritor, Shane M; Oleynikov, Dmitry

2010-06-27

Natural orifice translumenal endoscopic surgery (NOTES) is the integration of laparoscopic minimally invasive surgery techniques with endoscopic technology. Despite the advances in NOTES technology, the approach presents several unique instrumentation and technique-specific challenges. Current flexible endoscopy platforms for NOTES have several drawbacks including limited stability, triangulation and dexterity, and lack of adequate visualization, suggesting the need for new and improved instrumentation for this approach. Much of the current focus is on the development of flexible endoscopy platforms that incorporate robotic technology. An alternative approach to access the abdominal viscera for either a laparoscopic or NOTES procedure is the use of small robotic devices that can be implanted in an intracorporeal manner. Multiple, independent, miniature robots can be simultaneously inserted into the abdominal cavity to provide a robotic platform for NOTES surgery. The capabilities of the robots include imaging, retraction, tissue and organ manipulation, and precise maneuverability in the abdominal cavity. Such a platform affords several advantages including enhanced visualization, better surgical dexterity and improved triangulation for NOTES. This review discusses the current status and future perspectives of this novel miniature robotics platform for the NOTES approach. Although these technologies are still in pre-clinical development, a miniature robotics platform provides a unique method for addressing the limitations of minimally invasive surgery, and NOTES in particular.

Ultrafast nanoscale imaging using high order harmonic generation (Conference Presentation)

NASA Astrophysics Data System (ADS)

Merdji, Hamed

2017-05-01

Ultrafast coherent diffraction using soft and hard X-rays is actually revolutionizing imaging science thanks to new sources recently available. This powerful technique extends standard X-ray diffraction towards imaging of non-crystalline objects and leads actually to a strong impact in physics, chemistry and biology. New ultrashort pulses recently available hold the promise of watching matter evolving with unprecedented space and time resolution. Femtosecond coherent and intense radiation in the soft X-ray (λ = 10-40 nm) is currently produced in our laboratory, from highly non linear frequency conversion (high harmonic generation). A high intensity UV-X coherent beam is obtained using a loose focusing geometry, which allows coupling a very high amount of Ti:Sapphire laser system energy in the HHG process. Using a long gas cell and a long focal length lens, the emitting volume can be increased by orders of magnitude compared to standard HHG set-ups. This approach, allows reaching up to 1x1011 photons per shot for the 25th harmonic (λ=32nm). We have already demonstrated nanoscale imaging in a single shot mode reaching 70 nm spatial resolution and 20 femtoseconds snapshot [1]. We then implemented a recently proposed holographic technique using extended references. This technique, easy to implement, allows a direct non iterative image reconstruction. In the single shot regime, we demonstrated a spatial resolution of 110nm [2].This opens fascinating perspectives in imaging dynamical phenomena to be spread over a large scientific community. I will present recent results in the investigation of femtosecond phase spin-reversals of magnetic nano-domains [3]. Finally, I will report on recent development on noise sensitivity of the technique and perspectives in attosecond coherent imaging [4]. [1] A. Ravasio et al., Physical Review Letters 103, 028104 (2009). [2] D. Gauthier et al., Physical Review Letters 105, 093901 (2010). [3] Vodungbo et al., Nature Communications 3, 999 (2012) [4] Williams et al., Optics Letters 40 (13), 3205 (2015)

The Aesthetic Production and Distribution of Image/Subjects among Online Youth

ERIC Educational Resources Information Center

Leander, Kevin; Frank, Amy

2006-01-01

In this article the authors consider how youth engage in social practices of identity through their online practices with images. Although they build on social practice perspectives, informed by the new literacy studies, they question the extent to which such perspectives have created new autonomies and separations, including the separation of…

Mobile Neel skyrmions at room temperature: Status and future

DOE PAGES

Jiang, Wanjun; Zhang, Wei; Yu, Guoqiang; ...

2016-03-07

Magnetic skyrmions are topologically protected spin textures that exhibit many fascinating features. As compared to the well-studied cryogenic Bloch skyrmions in bulk materials, we focus on the room- temperature Néel skyrmions in thin-film systems with an interfacial broken inversion symmetry in this article. Specifically, we show the stabilization, the creation, and the implementation of Néel skyrmions that are enabled by the electrical current-induced spin-orbit torques. As a result, towards the nanoscale Néel skyrmions, we further discuss the challenges from both material optimization and imaging characterization perspectives.

LANDSAT-4 TM image data quality analysis for energy-related applications

NASA Technical Reports Server (NTRS)

Wukelic, G. E.; Foote, H. P.

1983-01-01

LANDSAT-4 Thematic Mapper (TM) data performance and utility characteristics from an energy research and technology perspective is evaluated. The program focuses on evaluating applicational implications of using such data, in combination with other digital data, for current and future energy research and technology activities. Prime interest is in using TM data for siting, developing and operating federal energy facilities. Secondary interests involve the use of such data for resource exploration, environmental monitoring and basic scientific initiatives such as in support of the Continental Scientific Drilling Program.

Recent advances in photoluminescence detection of fingerprints.

PubMed

Menzel, E R

2001-10-02

Photoluminescence detection of latent fingerprints has over the last quarter century brought about a new level of fingerprint detection sensitivity. The current state of the art is briefly reviewed to set the stage for upcoming new fingerprint processing strategies. These are designed for suppression of background fluorescence from articles holding latent prints, an often serious problem. The suppression of the background involves time-resolved imaging, which is dealt with from the perspective of instrumentation as well as the design of fingerprint treatment strategies. These focus on lanthanide chelates, nanocrystals, and nanocomposites functionalized to label fingerprints.

Osteosarcoma Overview.

PubMed

Lindsey, Brock A; Markel, Justin E; Kleinerman, Eugenie S

2017-06-01

Osteosarcoma (OS) is the most common primary malignancy of bone and patients with metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little prognostic improvement has been generated from the last 20 years of research and a new perspective is warranted. OS is extremely heterogeneous in both its origins and manifestations. Although multiple associations have been made between the development of osteosarcoma and race, gender, age, various genomic alterations, and exposure situations among others, the etiology remains unclear and controversial. Noninvasive diagnostic methods include serum markers like alkaline phosphatase and a growing variety of imaging techniques including X-ray, computed tomography, magnetic resonance imaging, and positron emission as well as combinations thereof. Still, biopsy and microscopic examination are required to confirm the diagnosis and carry additional prognostic implications such as subtype classification and histological response to neoadjuvant chemotherapy. The current standard of care combines surgical and chemotherapeutic techniques, with a multitude of experimental biologics and small molecules currently in development and some in clinical trial phases. In this review, in addition to summarizing the current understanding of OS etiology, diagnostic methods, and the current standard of care, our group describes various experimental therapeutics and provides evidence to encourage a potential paradigm shift toward the introduction of immunomodulation, which may offer a more comprehensive approach to battling cancer pleomorphism.

Emerging applications of conjugated polymers in molecular imaging.

PubMed

Li, Junwei; Liu, Jie; Wei, Chen-Wei; Liu, Bin; O'Donnell, Matthew; Gao, Xiaohu

2013-10-28

In recent years, conjugated polymers have attracted considerable attention from the imaging community as a new class of contrast agent due to their intriguing structural, chemical, and optical properties. Their size and emission wavelength tunability, brightness, photostability, and low toxicity have been demonstrated in a wide range of in vitro sensing and cellular imaging applications, and have just begun to show impact in in vivo settings. In this Perspective, we summarize recent advances in engineering conjugated polymers as imaging contrast agents, their emerging applications in molecular imaging (referred to as in vivo uses in this paper), as well as our perspectives on future research.

"In the storminess": multi-disciplinary approaches to scriptural images representing ethical challenges in the pastor-congregant relationship.

PubMed

O'Connor, Thomas St James; Walsh-Bowers, Richard; Psychology, Community; Ross, Christopher; Sawchuk, Dana; Hatzipantelis, Maria

2006-01-01

In this qualitative study the authors examine the Scriptural images that 10 Lutheran pastors employed in describing the ethical challenges in the pastor-congregant relationship. The analysis of Scriptural images is part of a larger study on pastors' experiences of a mandatory workshop, "Crossing the Boundaries (CTB),"which is required of Evangelical Lutheran Church in Canada (ELCIC) seminarians. The pastors' images were analyzed from the four perspectives of depth psychology, theology, social ethics, and sociology. In commenting on tensions in the pastors' Scriptural images the authors note commonalities among the four theoretical perspectives and discuss implications for practice and future research.

The impact of shifting vantage perspective when recalling and imagining positive events.

PubMed

Vella, Nicholas C; Moulds, Michelle L

2014-01-01

The vantage perspective from which memories are recalled influences their emotional impact. To date, however, the impact of vantage perspective on the emotions elicited by positive memories and images of positive future events has been minimally explored. We experimentally manipulated the vantage perspective from which a sample of undergraduate students (n =80) recalled positive memories and imagined positive future events. Participants who naturally recalled their positive memories from a field perspective reported decreased vividness and positive affect (i.e., happiness, optimism, hopefulness) when they were instructed to shift to an observer perspective. The same pattern of emotionality ratings was observed when participants' vantage perspective of imagined future events was manipulated. In contrast, shifting participants from observer to field perspective recall of positive memories did not result in changes in ratings of memory-related emotion, although we found an unexpected trend towards reduced vividness. For positive future events, shifting from an observer to a field perspective resulted in decreased vividness but did not lead to any changes in positive emotion. Our findings confirm that vantage perspective plays a key role in determining the emotional impact of positive memories, and demonstrate that this relationship is also evident for images of future positive events.

On Detailed Contrast of Biomedical Object in X-ray Dark-Field Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shimao, Daisuke; Mori, Koichi; Sugiyama, Hiroshi

2007-01-19

Over the past 10 years, refraction-based X-ray imaging has been studied together with a perspective view to clinical application. X-ray Dark-Field Imaging that utilizes a Laue geometry analyzer has recently been proposed and has the proven ability to depict articular cartilage in an intact human finger. In the current study, we researched detailed image contrast using X-ray Dark-Field Imaging by observing the edge contrast of an acrylic rod as a simple case, and found differences in image contrast between the right and left edges of the rod. This effect could cause undesirable contrast in the thin articular cartilage on themore » head of the phalanx. To avoid overlapping with this contrast at the articular cartilage, which would lead to a wrong diagnosis, we suggest that a joint surface on which articular cartilage is located should be aligned in the same sense as the scattering vector of the Laue case analyzer crystal. Defects of articular cartilage were successfully detected under this condition. When utilized under appropriate imaging conditions, X-ray Dark-Field Imaging will be a powerful tool for the diagnosis of arthropathy, as minute changes in articular cartilage may be early-stage features of this disease.« less

Weight status and body image perceptions in adolescents: current perspectives

PubMed Central

Voelker, Dana K; Reel, Justine J; Greenleaf, Christy

2015-01-01

Adolescence represents a pivotal stage in the development of positive or negative body image. Many influences exist during the teen years including transitions (eg, puberty) that affect one’s body shape, weight status, and appearance. Weight status exists along a spectrum between being obese (ie, where one’s body weight is in the 95th percentile for age and gender) to being underweight. Salient influences on body image include the media, which can target adolescents, and peers who help shape beliefs about the perceived body ideal. Internalization of and pressures to conform to these socially prescribed body ideals help to explain associations between weight status and body image. The concepts of fat talk and weight-related bullying during adolescence greatly contribute to an overemphasis on body weight and appearance as well as the development of negative body perceptions and dissatisfaction surrounding specific body parts. This article provides an overview of the significance of adolescent development in shaping body image, the relationship between body image and adolescent weight status, and the consequences of having a negative body image during adolescence (ie, disordered eating, eating disorders, and dysfunctional exercise). Practical implications for promoting a healthy weight status and positive body image among adolescents will be discussed. PMID:26347007

Principles and management of adrenal cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Javadpour, N.

1987-01-01

This book provides information on adrenal diseases of latest developments and guides the clinicians in the care of their patients. The book is divided into two parts. The first section gives an overview of the embryology, anatomy, physiology, markers, pathology, imaging and the current progress in the field. The second edition covers specific diseases of the adrenal cortex and medulla. The increasingly significant roles played by steroids, catecholamines, blockers, computed tomography and magnetic resonance are elucidated and discussed. The contents include: Overview of progress; current problems, and perspectives - embryology anatomy, physiology, and biologic markers; pathology; advances in diagnosis; imagingmore » techniques; adrenal disorders in childhood; primary aldosteronism; Cushing's syndrome; carcinoma; pheochromocytoma; neuroblastoma; metastatic disease; surgical management; and subject index.« less

Design and assessment of a novel SPECT system for desktop open-gantry imaging of small animals: A simulation study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeraatkar, Navid; Farahani, Mohammad Hossein; Rahmim, Arman

Purpose: Given increasing efforts in biomedical research utilizing molecular imaging methods, development of dedicated high-performance small-animal SPECT systems has been growing rapidly in the last decade. In the present work, we propose and assess an alternative concept for SPECT imaging enabling desktop open-gantry imaging of small animals. Methods: The system, PERSPECT, consists of an imaging desk, with a set of tilted detector and pinhole collimator placed beneath it. The object to be imaged is simply placed on the desk. Monte Carlo (MC) and analytical simulations were utilized to accurately model and evaluate the proposed concept and design. Furthermore, a dedicatedmore » image reconstruction algorithm, finite-aperture-based circular projections (FABCP), was developed and validated for the system, enabling more accurate modeling of the system and higher quality reconstructed images. Image quality was quantified as a function of different tilt angles in the acquisition and number of iterations in the reconstruction algorithm. Furthermore, more complex phantoms including Derenzo, Defrise, and mouse whole body were simulated and studied. Results: The sensitivity of the PERSPECT was 207 cps/MBq. It was quantitatively demonstrated that for a tilt angle of 30°, comparable image qualities were obtained in terms of normalized squared error, contrast, uniformity, noise, and spatial resolution measurements, the latter at ∼0.6 mm. Furthermore, quantitative analyses demonstrated that 3 iterations of FABCP image reconstruction (16 subsets/iteration) led to optimally reconstructed images. Conclusions: The PERSPECT, using a novel imaging protocol, can achieve comparable image quality performance in comparison with a conventional pinhole SPECT with the same configuration. The dedicated FABCP algorithm, which was developed for reconstruction of data from the PERSPECT system, can produce high quality images for small-animal imaging via accurate modeling of the system as incorporated in the forward- and back-projection steps. Meanwhile, the developed MC model and the analytical simulator of the system can be applied for further studies on development and evaluation of the system.« less

A Perspective of Our Planet's Atmosphere, Land, and Oceans: A View from Space

NASA Technical Reports Server (NTRS)

King, Michael D.; Tucker, Compton

2002-01-01

A birds eye view of the Earth from afar and up close reveals the power and magnificence of the Earth and juxtaposes the simultaneous impacts and powerlessness of humankind. The NASA Electronic Theater presents Earth science observations and visualizations in an historical perspective. Fly in from outer space to South America with its Andes Mountains and the glaciers of Patagonia, ending up close and personal in Buenos Aires. See the latest spectacular images from NASA & NOAA remote sensing missions like GOES, TRMM, Landsat 7, QuikScat, and Terra, which will be visualized and explained in the context of global change. See visualizations of global data sets currently available from Earth orbiting satellites, including the Earth at night with its city lights, aerosols from biomass burning in South America and Africa, and global cloud properties. See the dynamics of vegetation growth and decay over South America over 17 years, and its contrast to the North American and Africa continents. New visualization tools allow us to roam & zoom through massive global mosaic images from the Himalayas to the dynamics of the Pacific Ocean that affect the climate of South and North America. New visualization tools allow us to roam & zoom through massive global mosaic images including Landsat and Terra tours of South America and Africa showing land use and land cover change from Patagonia to the Amazon Basin, including the Andes Mountains, the Pantanal, and the Bolivian highlands. Landsat flyins to Rio Di Janeiro and Buenos Aires will be shows to emphasize the capabilities of new satellite technology to visualize our natural environment. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa and across the Atlantic to the Caribbean and Amazon basin. See ocean vortexes and currents that bring up the nutrients to feed tiny phytoplankton and draw the fish, giant whales and fisherman. See how the ocean blooms in response to these currents and El Nino/La Nina climate changes. We will illustrate these and other topics with a dynamic theater-style presentation, along with animations of satellite launch deployments and orbital mapping to highlight aspects of Earth observations from space.

Is pictorial perception robust? The effect of the observer vantage point on the perceived depth structure of linear-perspective images.

PubMed

Todorović, Dejan

2008-01-01

Every image of a scene produced in accord with the rules of linear perspective has an associated projection centre. Only if observed from that position does the image provide the stimulus which is equivalent to the one provided by the original scene. According to the perspective-transformation hypothesis, observing the image from other vantage points should result in specific transformations of the structure of the conveyed scene, whereas according to the vantage-point compensation hypothesis it should have little effect. Geometrical analyses illustrating the transformation theory are presented. An experiment is reported to confront the two theories. The results provide little support for the compensation theory and are generally in accord with the transformation theory, but also show systematic deviations from it, possibly due to cue conflict and asymmetry of visual angles.

The Sociology of Childhood as Scientific Communication: Observations from a Social Systems Perspective

ERIC Educational Resources Information Center

King, Michael

2007-01-01

This article begins by identifying a close relationship between the image of children generated by several sociologists working within the new sociology of childhood perspective and the claims and ambitions of the proponents of children's autonomy rights. The image of the child as a competent, self-controlled human agent are then subjected to…

Recent Updates in the Endoscopic Diagnosis of Barrett's Oesophagus.

PubMed

Sharma, Neel; Ho, Khek Yu

2016-10-01

Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. The mainstay diagnosis of BO is endoscopy and biopsy sampling. However, limitations with white light endoscopy (WLE) and undertaking biopsies have shifted the current focus towards real-time image analysis. Utilization of additional tools such as chromoendoscopy, narrow-band imaging (NBI), confocal laser endomicroscopy (CLE), and optical coherence tomography (OCT) are proving beneficial. Furthermore, it is also becoming more apparent that often these tools are utilized by experts in the field. Therefore, for the non-expert, training in these systems is key. Currently as yet, the methodologies used for training optimization require further inquiry. (1) Real-time imaging can serve to minimize excess biopsies. (2) Tools such as chromoendoscopy, NBI, CLE, and OCT can help to compliment WLE. WLE is associated with limited sensitivity. Biopsy sampling is cost-ineffective and associated with sampling error. Hence, from a practical perspective, endoscopists should aim to utilize additional tools to help in real-time image interpretation and minimize an overreliance on histology.

Recent Updates in the Endoscopic Diagnosis of Barrett's Oesophagus

PubMed Central

Sharma, Neel; Ho, Khek Yu

2016-01-01

Background Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. Summary The mainstay diagnosis of BO is endoscopy and biopsy sampling. However, limitations with white light endoscopy (WLE) and undertaking biopsies have shifted the current focus towards real-time image analysis. Utilization of additional tools such as chromoendoscopy, narrow-band imaging (NBI), confocal laser endomicroscopy (CLE), and optical coherence tomography (OCT) are proving beneficial. Furthermore, it is also becoming more apparent that often these tools are utilized by experts in the field. Therefore, for the non-expert, training in these systems is key. Currently as yet, the methodologies used for training optimization require further inquiry. Key Message (1) Real-time imaging can serve to minimize excess biopsies. (2) Tools such as chromoendoscopy, NBI, CLE, and OCT can help to compliment WLE. Practical Implications WLE is associated with limited sensitivity. Biopsy sampling is cost-ineffective and associated with sampling error. Hence, from a practical perspective, endoscopists should aim to utilize additional tools to help in real-time image interpretation and minimize an overreliance on histology. PMID:27904863

Digital image transformation and rectification of spacecraft and radar images

USGS Publications Warehouse

Wu, S.S.C.

1985-01-01

Digital image transformation and rectification can be described in three categories: (1) digital rectification of spacecraft pictures on workable stereoplotters; (2) digital correction of radar image geometry; and (3) digital reconstruction of shaded relief maps and perspective views including stereograms. Digital rectification can make high-oblique pictures workable on stereoplotters that would otherwise not accommodate such extreme tilt angles. It also enables panoramic line-scan geometry to be used to compile contour maps with photogrammetric plotters. Rectifications were digitally processed on both Viking Orbiter and Lander pictures of Mars as well as radar images taken by various radar systems. By merging digital terrain data with image data, perspective and three-dimensional views of Olympus Mons and Tithonium Chasma, also of Mars, are reconstructed through digital image processing. ?? 1985.

The Visual Journal as an Image Sphere: Interpreting Artworks with an Anamorphic Perspective

ERIC Educational Resources Information Center

Sinner, Anita

2011-01-01

During a 1-year study, the visual journal of a preservice teacher was explored as an image sphere, or "bildraum", in relation to teacher culture. Artworks created in the visual journal offered an anamorphic perspective on the materiality of teacher culture, tracing the lived experiences of a student of art in the process of becoming an art teacher…

American Immigrant Girls' Understanding of Female Body Image in Disney: A Critical Analysis of Young Korean Girls' Perspectives

ERIC Educational Resources Information Center

Lee, Lena

2009-01-01

This paper discusses young Korean immigrant girls' understanding of American popular culture in a small-scale qualitative study in order to disclose young American immigrant girls' perspectives on such culture. In particular, this paper explores how these Korean girls (age five to eight) perceive female body images in American popular culture -…

Automatic Cone Photoreceptor Localisation in Healthy and Stargardt Afflicted Retinas Using Deep Learning.

PubMed

Davidson, Benjamin; Kalitzeos, Angelos; Carroll, Joseph; Dubra, Alfredo; Ourselin, Sebastien; Michaelides, Michel; Bergeles, Christos

2018-05-21

We present a robust deep learning framework for the automatic localisation of cone photoreceptor cells in Adaptive Optics Scanning Light Ophthalmoscope (AOSLO) split-detection images. Monitoring cone photoreceptors with AOSLO imaging grants an excellent view into retinal structure and health, provides new perspectives into well known pathologies, and allows clinicians to monitor the effectiveness of experimental treatments. The MultiDimensional Recurrent Neural Network (MDRNN) approach developed in this paper is the first method capable of reliably and automatically identifying cones in both healthy retinas and retinas afflicted with Stargardt disease. Therefore, it represents a leap forward in the computational image processing of AOSLO images, and can provide clinical support in on-going longitudinal studies of disease progression and therapy. We validate our method using images from healthy subjects and subjects with the inherited retinal pathology Stargardt disease, which significantly alters image quality and cone density. We conduct a thorough comparison of our method with current state-of-the-art methods, and demonstrate that the proposed approach is both more accurate and appreciably faster in localizing cones. As further validation to the method's robustness, we demonstrate it can be successfully applied to images of retinas with pathologies not present in the training data: achromatopsia, and retinitis pigmentosa.

An Assessment of Imaging Informatics for Precision Medicine in Cancer.

PubMed

Chennubhotla, C; Clarke, L P; Fedorov, A; Foran, D; Harris, G; Helton, E; Nordstrom, R; Prior, F; Rubin, D; Saltz, J H; Shalley, E; Sharma, A

2017-08-01

Objectives: Precision medicine requires the measurement, quantification, and cataloging of medical characteristics to identify the most effective medical intervention. However, the amount of available data exceeds our current capacity to extract meaningful information. We examine the informatics needs to achieve precision medicine from the perspective of quantitative imaging and oncology. Methods: The National Cancer Institute (NCI) organized several workshops on the topic of medical imaging and precision medicine. The observations and recommendations are summarized herein. Results: Recommendations include: use of standards in data collection and clinical correlates to promote interoperability; data sharing and validation of imaging tools; clinician's feedback in all phases of research and development; use of open-source architecture to encourage reproducibility and reusability; use of challenges which simulate real-world situations to incentivize innovation; partnership with industry to facilitate commercialization; and education in academic communities regarding the challenges involved with translation of technology from the research domain to clinical utility and the benefits of doing so. Conclusions: This article provides a survey of the role and priorities for imaging informatics to help advance quantitative imaging in the era of precision medicine. While these recommendations were drawn from oncology, they are relevant and applicable to other clinical domains where imaging aids precision medicine. Georg Thieme Verlag KG Stuttgart.

Relative performance analysis of IR FPA technologies from the perspective of system level performance

NASA Astrophysics Data System (ADS)

Haran, Terence L.; James, J. Christopher; Cincotta, Tomas E.

2017-08-01

The majority of high performance infrared systems today utilize FPAs composed of intrinsic direct bandgap semiconductor photon detectors such as MCT or InSb. Quantum well detector technologies such as QWIPs, QDIPs, and SLS photodetectors are potentially lower cost alternatives to MCT and InSb, but the relative performance of these technologies has not been sufficiently high to allow widespread adoption outside of a handful of applications. While detectors are often evaluated using figures of merit such as NETD or D∗, these metrics, which include many underlying aspects such as spectral quantum efficiency, dark current, well size, MTF, and array response uniformity, may be far removed from the performance metrics used to judge performance of a system in an operationally relevant scenario. True comparisons of performance for various detector technologies from the perspective of end-to-end system performance have rarely been conducted, especially considering the rapid progress of the newer quantum well technologies. System level models such as the US Army's Night Vision Integrated Performance Model (NV-IPM) can calculate image contrast and spatial frequency content using data from the target/background, intervening atmosphere, and system components. This paper includes results from a performance parameter sensitivity analysis using NV-IPM to determine the relative importance of various FPA performance parameters to the overall performance of a long range imaging system. Parameters included are: QE, dark current density, quantum well capacity, downstream readout noise, well fill, image frame rate, frame averaging, and residual fixed pattern noise. The state-of-the art for XBn, QWIP, and SLS detector technologies operating in the MWIR and LWIR bands will be surveyed to assess performance of quantum structures compared to MCT and InSb. The intent is to provide a comprehensive assessment of quantum detector performance and to identify areas where increased research could provide the most benefit to overall system level performance.

Anatomical and functional brain imaging in adult attention-deficit/hyperactivity disorder (ADHD)--a neurological view.

PubMed

Schneider, Marc; Retz, Wolfgang; Coogan, Andrew; Thome, Johannes; Rösler, Michael

2006-09-01

In this review, we discuss current structural and functional imaging data on ADHD in a neurological and neuroanatomical framework. At present, the literature on adult ADHD is somewhat sparse, and so results from imaging have to therefore be considered mainly from the childhood or adolescence perspective. Most work has considered the impairment of executive functions (motor execution, inhibition, working memory), and as such a number of attention networks and their anatomical correlates are discussed in this review (e.g. the cerebello-(thalamo-)-striato-cortical network seems to play a pivotal role in ADHD pathology from childhood to adulthood). The core findings in ADHD imaging are alterations in the architecture and function of prefrontal cortex and cerebellum. The dorsal part of anterior cingulated cortex (dACC) is an important region for decision making, and executive control is impaired in adult ADHD. Finally, dysfunction of basal ganglia is a consistent finding in childhood and adulthood ADHD, reflecting dysregulation of fronto-striatal circuitry. The cerebellum, and its role in affect and cognition, is also persistently implicated in the pathology of ADHD.

Cancer imaging with CEA antibodies: historical and current perspectives.

PubMed

Goldenberg, D M

1992-01-01

This article reviews the history and status of cancer imaging with radiolabeled antibodies against carcinoembryonic antigen (CEA). Although CEA and many other cancer-associated antigens are not distinct for neoplasia, the quantitative increase of these markers in malignant tissues provides a sufficient differential for selective antibody targeting. Animal studies with xenografted human tumors provided the first evidence of the prospects of this technology, followed by initial clinical success with purified goat whole IgG antibodies to CEA, labeled with 131I and with the use of dual-isotope subtraction methods. Subsequently, improved and earlier imaging could be accomplished with monoclonal antibody fragments, which then would permit the use of shorter-lived radionuclides, such as 111In, 123I, and 99mTc. The preferred use of a monoclonal anti-CEA IgG Fab' fragment, labeled with 99mTc by a recently developed, simple and rapid kit, has enabled the detection of small lesions, including those in the liver, within 4 h of injection. By means of SPECT imaging, a high sensitivity and specificity for RAID could be achieved.

Interactive 2D to 3D stereoscopic image synthesis

NASA Astrophysics Data System (ADS)

Feldman, Mark H.; Lipton, Lenny

2005-03-01

Advances in stereoscopic display technologies, graphic card devices, and digital imaging algorithms have opened up new possibilities in synthesizing stereoscopic images. The power of today"s DirectX/OpenGL optimized graphics cards together with adapting new and creative imaging tools found in software products such as Adobe Photoshop, provide a powerful environment for converting planar drawings and photographs into stereoscopic images. The basis for such a creative process is the focus of this paper. This article presents a novel technique, which uses advanced imaging features and custom Windows-based software that utilizes the Direct X 9 API to provide the user with an interactive stereo image synthesizer. By creating an accurate and interactive world scene with moveable and flexible depth map altered textured surfaces, perspective stereoscopic cameras with both visible frustums and zero parallax planes, a user can precisely model a virtual three-dimensional representation of a real-world scene. Current versions of Adobe Photoshop provide a creative user with a rich assortment of tools needed to highlight elements of a 2D image, simulate hidden areas, and creatively shape them for a 3D scene representation. The technique described has been implemented as a Photoshop plug-in and thus allows for a seamless transition of these 2D image elements into 3D surfaces, which are subsequently rendered to create stereoscopic views.

Enhancements for digital imaging of gusset plate connections : fisheye and image stitching.

DOT National Transportation Integrated Search

2011-09-01

This report describes techniques to convert fisheye digital images of gusset plates to perspective images (defish). It also describes methods to stitch together partial images of a gusset plate into a composite of the complete gusset plate. The conve...

An application of the MPP to the interactive manipulation of stereo images of digital terrain models

NASA Technical Reports Server (NTRS)

Pol, Sanjay; Mcallister, David; Davis, Edward

1987-01-01

Massively Parallel Processor algorithms were developed for the interactive manipulation of flat shaded digital terrain models defined over grids. The emphasis is on real time manipulation of stereo images. Standard graphics transformations are applied to a 128 x 128 grid of elevations followed by shading and a perspective projection to produce the right eye image. The surface is then rendered using a simple painter's algorithm for hidden surface removal. The left eye image is produced by rotating the surface 6 degs about the viewer's y axis followed by a perspective projection and rendering of the image as described above. The left and right eye images are then presented on a graphics device using standard stereo technology. Performance evaluations and comparisons are presented.

MOLECULAR DESIGNER: an interactive program for the display of protein structure on the IBM-PC.

PubMed

Hannon, G J; Jentoft, J E

1985-09-01

A BASIC interactive graphics program has been developed for the IBM-PC which utilizes the graphics capabilities of that computer to display and manipulate protein structure from coordinates. Structures may be generated from typed files, or from Brookhaven National Laboratories' Protein Data Bank data tapes. Once displayed, images may be rotated, translated and expanded to any desired size. Figures may be viewed as ball-and-stick or space-filling models. Calculated multiple-point perspective may also be added to the display. Docking manipulations are possible since more than a single figure may be displayed and manipulated simultaneously. Further, stereo images and red/blue three-dimensional images may be generated using the accompanying DESIPLOT program and an HP-7475A plotter. A version of the program is also currently available for the Apple Macintosh. Full implementation on the Macintosh requires 512 K and at least one disk drive. Otherwise this version is essentially identical to the IBM-PC version described herein.

Hyperspectral imaging solutions for brain tissue metabolic and hemodynamic monitoring: past, current and future developments

NASA Astrophysics Data System (ADS)

Giannoni, Luca; Lange, Frédéric; Tachtsidis, Ilias

2018-04-01

Hyperspectral imaging (HSI) technologies have been used extensively in medical research, targeting various biological phenomena and multiple tissue types. Their high spectral resolution over a wide range of wavelengths enables acquisition of spatial information corresponding to different light-interacting biological compounds. This review focuses on the application of HSI to monitor brain tissue metabolism and hemodynamics in life sciences. Different approaches involving HSI have been investigated to assess and quantify cerebral activity, mainly focusing on: (1) mapping tissue oxygen delivery through measurement of changes in oxygenated (HbO2) and deoxygenated (HHb) hemoglobin; and (2) the assessment of the cerebral metabolic rate of oxygen (CMRO2) to estimate oxygen consumption by brain tissue. Finally, we introduce future perspectives of HSI of brain metabolism, including its potential use for imaging optical signals from molecules directly involved in cellular energy production. HSI solutions can provide remarkable insight in understanding cerebral tissue metabolism and oxygenation, aiding investigation on brain tissue physiological processes.

A 10-Fr ultrasound catheter with integrated micromotor for 4-D intracardiac echocardiography.

PubMed

Lee, Warren; Griffin, Weston; Wildes, Douglas; Buckley, Donald; Topka, Terry; Chodakauskas, Thaddeus; Langer, Mark; Calisti, Serge; Bergstøl, Svein; Malacrida, Jean-Pierre; Lanteri, Frédéric; Maffre, Jennifer; McDaniel, Ben; Shivkumar, Kalyanam; Cummings, Jennifer; Callans, David; Silvestry, Frank; Packer, Douglas

2011-07-01

We developed prototype real-time 3-D intracardiac echocardiography catheters with integrated micromotors, allowing internal oscillation of a low-profile 64-element, 6.2-MHz phased-array transducer in the elevation direction. Components were designed to facilitate rotation of the array, including a low-torque flexible transducer interconnect and miniature fixtures for the transducer and micromotor. The catheter tip prototypes were integrated with two-way deflectable 10-Fr catheters and used in in vivo animal testing at multiple facilities. The 4-D ICE catheters were capable of imaging a 90° azimuth by up to 180° elevation field of view. Volume rates ranged from 1 vol/sec (180° elevation) to approximately 10 vol/sec (60° elevation). We successfully imaged electrophysiology catheters, atrial septal puncture procedures, and detailed cardiac anatomy. The elevation oscillation enabled 3-D visualization of devices and anatomy, providing new clinical information and perspective not possible with current 2-D imaging catheters.

Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations

NASA Astrophysics Data System (ADS)

Ewing, Andrew V.; Kazarian, Sergei G.

2018-05-01

Vibrational spectroscopic imaging and mapping approaches have continued in their development and applications for the analysis of pharmaceutical formulations. Obtaining spatially resolved chemical information about the distribution of different components within pharmaceutical formulations is integral for improving the understanding and quality of final drug products. This review aims to summarise some key advances of these technologies over recent years, primarily since 2010. An overview of FTIR, NIR, terahertz spectroscopic imaging and Raman mapping will be presented to give a perspective of the current state-of-the-art of these techniques for studying pharmaceutical samples. This will include their application to reveal spatial information of components that reveals molecular insight of polymorphic or structural changes, behaviour of formulations during dissolution experiments, uniformity of materials and detection of counterfeit products. Furthermore, new advancements will be presented that demonstrate the continuing novel applications of spectroscopic imaging and mapping, namely in FTIR spectroscopy, for studies of microfluidic devices. Whilst much of the recently developed work has been reported by academic groups, examples of the potential impacts of utilising these imaging and mapping technologies to support industrial applications have also been reviewed.

The contribution of Medical Physics to Nuclear Medicine: looking back - a physicist's perspective.

PubMed

Hutton, Brian F

2014-12-01

This paper is the first in a series of invited perspectives by four pioneers of Nuclear Medicine imaging and physics. A medical physicist and a Nuclear Medicine clinical specialist each take a backward look and a forward look at the contributions of Medical Physics to Nuclear Medicine. Contributions of Medical Physics are presented from the early discovery of radioactivity, development of first imaging devices, computers and emission tomography to recent development of hybrid imaging. There is evidence of significant contribution of Medical Physics throughout the development of Nuclear Medicine.

The extent of visual space inferred from perspective angles

PubMed Central

Erkelens, Casper J.

2015-01-01

Retinal images are perspective projections of the visual environment. Perspective projections do not explain why we perceive perspective in 3-D space. Analysis of underlying spatial transformations shows that visual space is a perspective transformation of physical space if parallel lines in physical space vanish at finite distance in visual space. Perspective angles, i.e., the angle perceived between parallel lines in physical space, were estimated for rails of a straight railway track. Perspective angles were also estimated from pictures taken from the same point of view. Perspective angles between rails ranged from 27% to 83% of their angular size in the retinal image. Perspective angles prescribe the distance of vanishing points of visual space. All computed distances were shorter than 6 m. The shallow depth of a hypothetical space inferred from perspective angles does not match the depth of visual space, as it is perceived. Incongruity between the perceived shape of a railway line on the one hand and the experienced ratio between width and length of the line on the other hand is huge, but apparently so unobtrusive that it has remained unnoticed. The incompatibility between perspective angles and perceived distances casts doubt on evidence for a curved visual space that has been presented in the literature and was obtained from combining judgments of distances and angles with physical positions. PMID:26034567

Latest advances in confocal microscopy of skin cancers toward guiding patient care: a Mohs surgeon's review and perspective (Conference Presentation)

NASA Astrophysics Data System (ADS)

Nehal, Kishwer S.; Rajadhyaksha, Milind

2016-02-01

Latest advances in confocal microscopy of skin cancers toward guiding patient care: a Mohs surgeon's review and perspective About 350 publications worldwide have reported the ability of reflectance confocal microscopy (RCM) imaging to detect melanocytic skin lesions in vivo with specificity of 84-88% and sensitivity of 71-92%, and non-melanocytic skin lesions with specificity of 85-97% and sensitivity 100-92%. Lentigo maligna melanoma can be detected with sensitivity of 93% and specificity 82%. While the sensitivity is comparable to that of dermoscopy, the specificity is 2X superior, especially for lightly- and non-pigmented lesions. Dermoscopy combined with RCM imaging is proving to be both highly sensitive and highly specific. Recent studies have reported that the ratio of equivocal (i.e., would have been biopsied) lesions to detected melanomas dropped by ~2X when guided by dermoscopy and RCM imaging, compared to that with dermoscopy alone. Dermoscopy combined with RCM imaging is now being implemented to guide noninvasive diagnosis (to rule out malignancy and biopsy) and to also guide treatment, with promising initial impact: thus far, about 3,000 patients have been saved from biopsies of benign lesions. These are currently under follow-up monitoring. With fluorescence confocal microscopy (FCM) mosaicing, residual basal cell carcinomas can be detected in Mohs surgically excised fresh tissue ex vivo, with sensitivity of 94-97% and specificity 89-94%. FCM mosaicing is now being implemented for guiding Mohs surgery. To date, about 600 Mohs procedures have been performed, guided with mosaicing, and with pathology being performed in parallel to confirm the final outcome. These latest advances demonstrate the promising ability of RCM and FCM to guide patient care.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Is Non-invasive Image-Guided Breast Brachytherapy Good? – Jess Hiatt, MS Non-invasive Image-Guided Breast Brachytherapy (NIBB) is an emerging therapy for breast boost treatments as well as Accelerated Partial Breast Irradiation (APBI) using HDR surface breast brachytherapy. NIBB allows for smaller treatment volumes while maintaining optimal target coverage. Considering the real-time image-guidance and immobilization provided by the NIBB modality, minimal margins around the target tissue are necessary. Accelerated Partial Breast Irradiation in brachytherapy: is shorter better? - Dorin Todor, PhD VCU A review of balloon and strut devices will be provided together with the origins of APBI: the interstitial multi-catheter implant.more » A dosimetric and radiobiological perspective will help point out the evolution in breast brachytherapy, both in terms of devices and the protocols/clinical trials under which these devices are used. Improvements in imaging, delivery modalities and convenience are among the factors driving the ultrashort fractionation schedules but our understanding of both local control and toxicities associated with various treatments is lagging. A comparison between various schedules, from a radiobiological perspective, will be given together with a critical analysis of the issues. to review and understand the evolution and development of APBI using brachytherapy methods to understand the basis and limitations of radio-biological ‘equivalence’ between fractionation schedules to review commonly used and proposed fractionation schedules Intra-operative breast brachytherapy: Is one stop shopping best?- Bruce Libby, PhD. University of Virginia A review of intraoperative breast brachytherapy will be presented, including the Targit-A and other trials that have used electronic brachytherapy. More modern approaches, in which the lumpectomy procedure is integrated into an APBI workflow, will also be discussed. Learning Objectives: To review past and current clinical trials for IORT To discuss lumpectomy-scan-plan-treat workflow for IORT.« less

Simultaneous AFM topography and recognition imaging at the plasma membrane of mammalian cells.

PubMed

Chtcheglova, Lilia A; Hinterdorfer, Peter

2018-01-01

Elucidation the nano-organization of membrane proteins at/within the plasma membrane is probably the most demanding and still challenging task in cell biology since requires experimental approaches with nanoscale resolution. During last decade, atomic force microscopy (AFM)-based simultaneous topography and recognition imaging (TREC) has become a powerful tool to quickly obtain local receptor nano-maps on complex heterogeneous biosurfaces such as cells and membranes. Here we emphasize the TREC technique and explain how to unravel the nano-landscape of mammalian cells. We describe the procedures for all steps of the experiment including tip functionalization with ligand molecules, sample preparation, and localization of key molecules on the cell surface. We also discuss the current limitations and future perspectives of this technique. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Format and basic geometry of a perspective display of air traffic for the cockpit

DOT National Transportation Integrated Search

1991-06-01

The design and implementation of a perspective display of air traffic for the cockpit is discussed. Parameters of the perspective are variable and interactive so that the appearance of the projected image can be widely varied. This approach makes all...

Multiparametric prostate MRI: technical conduct, standardized report and clinical use.

PubMed

Manfredi, Matteo; Mele, Fabrizio; Garrou, Diletta; Walz, Jochen; Fütterer, Jurgen J; Russo, Filippo; Vassallo, Lorenzo; Villers, Arnauld; Emberton, Mark; Valerio, Massimo

2018-02-01

Multiparametric prostate MRI (mp-MRI) is an emerging imaging modality for diagnosis, characterization, staging, and treatment planning of prostate cancer (PCa). The technique, results reporting, and its role in clinical practice have been the subject of significant development over the last decade. Although mp-MRI is not yet routinely used in the diagnostic pathway, almost all urological guidelines have emphasized the potential role of mp-MRI in several aspects of PCa management. Moreover, new MRI sequences and scanning techniques are currently under evaluation to improve the diagnostic accuracy of mp-MRI. This review presents an overview of mp-MRI, summarizing the technical applications, the standardized reporting systems used, and their current roles in various stages of PCa management. Finally, this critical review also reports the main limitations and future perspectives of the technique.

Flight of the dragonflies and damselflies.

PubMed

Bomphrey, Richard J; Nakata, Toshiyuki; Henningsson, Per; Lin, Huai-Ti

2016-09-26

This work is a synthesis of our current understanding of the mechanics, aerodynamics and visually mediated control of dragonfly and damselfly flight, with the addition of new experimental and computational data in several key areas. These are: the diversity of dragonfly wing morphologies, the aerodynamics of gliding flight, force generation in flapping flight, aerodynamic efficiency, comparative flight performance and pursuit strategies during predatory and territorial flights. New data are set in context by brief reviews covering anatomy at several scales, insect aerodynamics, neuromechanics and behaviour. We achieve a new perspective by means of a diverse range of techniques, including laser-line mapping of wing topographies, computational fluid dynamics simulations of finely detailed wing geometries, quantitative imaging using particle image velocimetry of on-wing and wake flow patterns, classical aerodynamic theory, photography in the field, infrared motion capture and multi-camera optical tracking of free flight trajectories in laboratory environments. Our comprehensive approach enables a novel synthesis of datasets and subfields that integrates many aspects of flight from the neurobiology of the compound eye, through the aeromechanical interface with the surrounding fluid, to flight performance under cruising and higher-energy behavioural modes.This article is part of the themed issue 'Moving in a moving medium: new perspectives on flight'. © 2016 The Authors.

Flight of the dragonflies and damselflies

PubMed Central

Nakata, Toshiyuki; Henningsson, Per; Lin, Huai-Ti

2016-01-01

This work is a synthesis of our current understanding of the mechanics, aerodynamics and visually mediated control of dragonfly and damselfly flight, with the addition of new experimental and computational data in several key areas. These are: the diversity of dragonfly wing morphologies, the aerodynamics of gliding flight, force generation in flapping flight, aerodynamic efficiency, comparative flight performance and pursuit strategies during predatory and territorial flights. New data are set in context by brief reviews covering anatomy at several scales, insect aerodynamics, neuromechanics and behaviour. We achieve a new perspective by means of a diverse range of techniques, including laser-line mapping of wing topographies, computational fluid dynamics simulations of finely detailed wing geometries, quantitative imaging using particle image velocimetry of on-wing and wake flow patterns, classical aerodynamic theory, photography in the field, infrared motion capture and multi-camera optical tracking of free flight trajectories in laboratory environments. Our comprehensive approach enables a novel synthesis of datasets and subfields that integrates many aspects of flight from the neurobiology of the compound eye, through the aeromechanical interface with the surrounding fluid, to flight performance under cruising and higher-energy behavioural modes. This article is part of the themed issue ‘Moving in a moving medium: new perspectives on flight’. PMID:27528779

SPECT and PET radiopharmaceuticals for molecular imaging of apoptosis: from bench to clinic

PubMed Central

Wang, Xiaobo; Feng, Han; Zhao, Shichao; Xu, Junling; Wu, Xinyu; Cui, Jing; Zhang, Ying; Qin, Yuhua; Liu, Zhiguo; Gao, Tang; Gao, Yongju; Zeng, Wenbin

2017-01-01

Owing to the central role of apoptosis in many human diseases and the wide-spread application of apoptosis-based therapeutics, molecular imaging of apoptosis in clinical practice is of great interest for clinicians, and holds great promises. Based on the well-defined biochemical changes for apoptosis, a rich assortment of probes and approaches have been developed for molecular imaging of apoptosis with various imaging modalities. Among these imaging techniques, nuclear imaging (including single photon emission computed tomography and positron emission tomography) remains the premier clinical method owing to their high specificity and sensitivity. Therefore, the corresponding radiopharmaceuticals have been a major focus, and some of them like 99mTc-Annexin V, 18F-ML-10, 18F-CP18, and 18F-ICMT-11 are currently under clinical investigations in Phase I/II or Phase II/III clinical trials on a wide scope of diseases. In this review, we summarize these radiopharmaceuticals that have been widely used in clinical trials and elaborate them in terms of radiosynthesis, pharmacokinetics and dosimetry, and their applications in different clinical stages. We also explore the unique features required to qualify a desirable radiopharmaceutical for imaging apoptosis in clinical practice. Particularly, a perspective of the impact of these clinical efforts, namely, apoptosis imaging as predictive and prognostic markers, early-response indicators and surrogate endpoints, is also the highlight of this review. PMID:28108738

Real-time 3-D X-ray and gamma-ray viewer

NASA Technical Reports Server (NTRS)

Yin, L. I. (Inventor)

1983-01-01

A multi-pinhole aperture lead screen forms an equal plurality of invisible mini-images having dissimilar perspectives of an X-ray and gamma-ray emitting object (ABC) onto a near-earth phosphor layer. This layer provides visible light mini-images directly into a visible light image intensifier. A viewing screen having an equal number of dissimilar perspective apertures distributed across its face in a geometric pattern identical to the lead screen, provides a viewer with a real, pseudoscopic image (A'B'C') of the object with full horizontal and vertical parallax. Alternatively, a third screen identical to viewing screen and spaced apart from a second visible light image intensifier, may be positioned between the first image intensifier and the viewing screen, thereby providing the viewer with a virtual, orthoscopic image (A"B"C") of the object (ABC) with full horizontal and vertical parallax.

Borderline resectable pancreatic cancer: conceptual evolution and current approach to image-based classification.

PubMed

Gilbert, J W; Wolpin, B; Clancy, T; Wang, J; Mamon, H; Shinagare, A B; Jagannathan, J; Rosenthal, M

2017-09-01

Diagnostic imaging plays a critical role in the initial diagnosis and therapeutic monitoring of pancreatic adenocarcinoma. Over the past decade, the concept of 'borderline resectable' pancreatic cancer has emerged to describe a distinct subset of patients existing along the spectrum from resectable to locally advanced disease for whom a microscopically margin-positive (R1) resection is considered relatively more likely, primarily due to the relationship of the primary tumor with surrounding vasculature. This review traces the conceptual evolution of borderline resectability from a radiological perspective, including the debates over the key imaging criteria that define the thresholds between resectable, borderline resectable, and locally advanced or metastatic disease. This review also addresses the data supporting neoadjuvant therapy in this population and discusses current imaging practices before and during treatment. A growing body of evidence suggests that the borderline resectable group of patients may particularly benefit from neoadjuvant therapy to increase the likelihood of an ultimately margin-negative (R0) resection. Unfortunately, anatomic and imaging criteria to define borderline resectability are not yet universally agreed upon, with several classification systems proposed in the literature and considerable variance in institution-by-institution practice. As a result of this lack of consensus, as well as overall small patient numbers and lack of established clinical trials dedicated to borderline resectable patients, accurate evidence-based diagnostic categorization and treatment selection for this subset of patients remains a significant challenge. Clinicians and radiologists alike should be cognizant of evolving imaging criteria for borderline resectability given their profound implications for treatment strategy, follow-up recommendations, and prognosis. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Positron Emission Tomography Image-Guided Drug Delivery: Current Status and Future Perspectives

PubMed Central

2015-01-01

Positron emission tomography (PET) is an important modality in the field of molecular imaging, which is gradually impacting patient care by providing safe, fast, and reliable techniques that help to alter the course of patient care by revealing invasive, de facto procedures to be unnecessary or rendering them obsolete. Also, PET provides a key connection between the molecular mechanisms involved in the pathophysiology of disease and the according targeted therapies. Recently, PET imaging is also gaining ground in the field of drug delivery. Current drug delivery research is focused on developing novel drug delivery systems with emphasis on precise targeting, accurate dose delivery, and minimal toxicity in order to achieve maximum therapeutic efficacy. At the intersection between PET imaging and controlled drug delivery, interest has grown in combining both these paradigms into clinically effective formulations. PET image-guided drug delivery has great potential to revolutionize patient care by in vivo assessment of drug biodistribution and accumulation at the target site and real-time monitoring of the therapeutic outcome. The expected end point of this approach is to provide fundamental support for the optimization of innovative diagnostic and therapeutic strategies that could contribute to emerging concepts in the field of “personalized medicine”. This review focuses on the recent developments in PET image-guided drug delivery and discusses intriguing opportunities for future development. The preclinical data reported to date are quite promising, and it is evident that such strategies in cancer management hold promise for clinically translatable advances that can positively impact the overall diagnostic and therapeutic processes and result in enhanced quality of life for cancer patients. PMID:24865108

Atypical Cities

ERIC Educational Resources Information Center

DiJulio, Betsy

2011-01-01

In this creative challenge, Surrealism and one-point perspective combine to produce images that not only go "beyond the real" but also beyond the ubiquitous "imaginary city" assignment often used to teach one-point perspective. Perhaps the difference is that in the "atypical cities challenge," an understanding of one-point perspective is a means…

[Digital breast tomosynthesis : technical principles, current clinical relevance and future perspectives].

PubMed

Hellerhoff, K

2010-11-01

In recent years digital full field mammography has increasingly replaced conventional film mammography. High quality imaging is guaranteed by high quantum efficiency and very good contrast resolution with optimized dosing even for women with dense glandular tissue. However, digital mammography remains a projection procedure by which overlapping tissue limits the detectability of subtle alterations. Tomosynthesis is a procedure developed from digital mammography for slice examination of breasts which eliminates the effects of overlapping tissue and allows 3D imaging of breasts. A curved movement of the X-ray tube during scanning allows the acquisition of many 2D images from different angles. Subseqently, reconstruction algorithms employing a shift and add method improve the recognition of details at a defined level and at the same time eliminate smear artefacts due to overlapping structures. The total dose corresponds to that of conventional mammography imaging. The technical procedure, including the number of levels, suitable anodes/filter combinations, angle regions of images and selection of reconstruction algorithms, is presently undergoing optimization. Previous studies on the clinical value of tomosynthesis have examined screening parameters, such as recall rate and detection rate as well as information on tumor extent for histologically proven breast tumors. More advanced techniques, such as contrast medium-enhanced tomosynthesis, are presently under development and dual-energy imaging is of particular importance.

Comprehensive Modeling and Visualization of Cardiac Anatomy and Physiology from CT Imaging and Computer Simulations

PubMed Central

Sun, Peng; Zhou, Haoyin; Ha, Seongmin; Hartaigh, Bríain ó; Truong, Quynh A.; Min, James K.

2016-01-01

In clinical cardiology, both anatomy and physiology are needed to diagnose cardiac pathologies. CT imaging and computer simulations provide valuable and complementary data for this purpose. However, it remains challenging to gain useful information from the large amount of high-dimensional diverse data. The current tools are not adequately integrated to visualize anatomic and physiologic data from a complete yet focused perspective. We introduce a new computer-aided diagnosis framework, which allows for comprehensive modeling and visualization of cardiac anatomy and physiology from CT imaging data and computer simulations, with a primary focus on ischemic heart disease. The following visual information is presented: (1) Anatomy from CT imaging: geometric modeling and visualization of cardiac anatomy, including four heart chambers, left and right ventricular outflow tracts, and coronary arteries; (2) Function from CT imaging: motion modeling, strain calculation, and visualization of four heart chambers; (3) Physiology from CT imaging: quantification and visualization of myocardial perfusion and contextual integration with coronary artery anatomy; (4) Physiology from computer simulation: computation and visualization of hemodynamics (e.g., coronary blood velocity, pressure, shear stress, and fluid forces on the vessel wall). Substantially, feedback from cardiologists have confirmed the practical utility of integrating these features for the purpose of computer-aided diagnosis of ischemic heart disease. PMID:26863663

Pediatric Epilepsy: Neurology, Functional Imaging, and Neurosurgery.

PubMed

Mountz, James M; Patterson, Christina M; Tamber, Mandeep S

2017-03-01

In this chapter we provide a comprehensive review of the current role that functional imaging can have in the care of the pediatric epilepsy patient from the perspective of the epilepsy neurologist and the epilepsy neurosurgeon. In the neurology section, the diagnosis and classification of epilepsy adapted by the International League Against Epilepsy as well as the etiology and incidence of the disease is presented. The neuroimaging section describes how advanced nuclear medicine imaging methods can be synergized to provide a maximum opportunity to localize an epileptogenic focus. This section described the value of FDG-PET and regional cerebral blood flow SPECT in the identification of an epileptogenic focus. The imaging section also emphasizes the importance on developing a dedicated epilepsy management team, comprised of an epilepsy imaging specialist, epilepsy neurologist and epilepsy neurosurgeon, to provide the maximum benefit to each child with epilepsy. An emphasis is placed on preparation for ictal SPECT injection procedures, including the critical role of an automated injector well as the use of state-of-the-art dedicated nuclear medicine imaging and analysis protocols to correctly localize the epileptogenic focus location. In the final section, surgical options, approaches and expected outcomes for the different classes of epilepsy is presented. Copyright © 2017 Elsevier Inc. All rights reserved.

Emerging roles for integrated imaging modalities in cardiovascular cell-based therapeutics: a clinical perspective

PubMed Central

Psaltis, Peter J.; Simari, Robert D.

2012-01-01

Despite preclinical promise, the progress of cell-based therapy to clinical cardiovascular practice has been slowed by several challenges and uncertainties that have been highlighted by the conflicting results of human trials. Most telling has been the revelation that current strategies fall short of achieving sufficient retention and engraftment of cells to meet the ambitious objective of myocardial regeneration. This has sparked novel research into the refinement of cell biology and delivery to overcome these shortcomings. Within this context, molecular imaging has emerged as a valuable tool for providing noninvasive surveillance of cell fate in vivo. Direct and indirect labelling of cells can be coupled with clinically relevant imaging modalities, such as radionuclide single photon emission computed tomography and positron emission tomography, and magnetic resonance imaging, to assess their short- and long-term distributions, along with their viability, proliferation and functional interaction with the host myocardium. This review details the strengths and limitations of the different cell labelling and imaging techniques and their potential application to the clinical realm. We also consider the broader, multifaceted utility of imaging throughout the cell therapy process, providing a discussion of its considerable value during cell delivery and its importance during the evaluation of cardiac outcomes in clinical studies. PMID:21901381

Image Representation and Interactivity: An Exploration of Utility Values, Information-Needs and Image Interactivity

ERIC Educational Resources Information Center

Lewis, Elise C.

2011-01-01

This study was designed to explore the relationships between users and interactive images. Three factors were identified and provided different perspectives on how users interact with images: image utility, information-need, and images with varying levels of interactivity. The study used a mixed methodology to gain a more comprehensive…

Ethical Perspectives on the Current Controversy Regarding Openness in Adoption.

ERIC Educational Resources Information Center

Tavis, Timothy M.

This paper outlines current changes in American adoption practice and the controversies surrounding these changes. It includes a discussion of the role that neo-Kantian and utilitarian perspectives have played in American adoption policy and practice, and offers an alternative, the communitarian perspective, described by Sandel (1984). Adoption…

Venus - 3D Perspective View of Maat Mons

NASA Technical Reports Server (NTRS)

1991-01-01

Maat Mons is displayed in this three-dimensional perspective view of the surface of Venus. The viewpoint is located 560 kilometers (347 miles) north of Maat Mons at an elevation of 1.7 kilometers (1 mile) above the terrain. Lava flows extend for hundreds of kilometers across the fractured plains shown in the foreground, to the base of Maat Mons. The view is to the south with Maat Mons appearing at the center of the image on the horizon. Maat Mons, an 8-kilometer (5 mile) high volcano, is located at approximately 0.9 degrees north latitude, 194.5 degrees east longitude. Maat Mons is named for an Egyptian goddess of truth and justice. Magellan synthetic aperture radar data is combined with radar altimetry to develop a three-dimensional map of the surface. The vertical scale in this perspective has been exaggerated 22.5 times. Rays cast in a computer intersect the surface to create a three-dimensional perspective view. Simulated color and a digital elevation map developed by the U.S. Geological Survey, are used to enhance small-scale structure. The simulated hues are based on color images recorded by the Soviet Venera 13 and 14 spacecraft. The image was produced at the JPL Multimission Image Processing Laboratory.

Perspectives on Machine Learning for Classification of Schizotypy Using fMRI Data.

PubMed

Madsen, Kristoffer H; Krohne, Laerke G; Cai, Xin-Lu; Wang, Yi; Chan, Raymond C K

2018-03-15

Functional magnetic resonance imaging is capable of estimating functional activation and connectivity in the human brain, and lately there has been increased interest in the use of these functional modalities combined with machine learning for identification of psychiatric traits. While these methods bear great potential for early diagnosis and better understanding of disease processes, there are wide ranges of processing choices and pitfalls that may severely hamper interpretation and generalization performance unless carefully considered. In this perspective article, we aim to motivate the use of machine learning schizotypy research. To this end, we describe common data processing steps while commenting on best practices and procedures. First, we introduce the important role of schizotypy to motivate the importance of reliable classification, and summarize existing machine learning literature on schizotypy. Then, we describe procedures for extraction of features based on fMRI data, including statistical parametric mapping, parcellation, complex network analysis, and decomposition methods, as well as classification with a special focus on support vector classification and deep learning. We provide more detailed descriptions and software as supplementary material. Finally, we present current challenges in machine learning for classification of schizotypy and comment on future trends and perspectives.

Comparison and evaluation on image fusion methods for GaoFen-1 imagery

NASA Astrophysics Data System (ADS)

Zhang, Ningyu; Zhao, Junqing; Zhang, Ling

2016-10-01

Currently, there are many research works focusing on the best fusion method suitable for satellite images of SPOT, QuickBird, Landsat and so on, but only a few of them discuss the application of GaoFen-1 satellite images. This paper proposes a novel idea by using four fusion methods, such as principal component analysis transform, Brovey transform, hue-saturation-value transform, and Gram-Schmidt transform, from the perspective of keeping the original image spectral information. The experimental results showed that the transformed images by the four fusion methods not only retain high spatial resolution on panchromatic band but also have the abundant spectral information. Through comparison and evaluation, the integration of Brovey transform is better, but the color fidelity is not the premium. The brightness and color distortion in hue saturation-value transformed image is the largest. Principal component analysis transform did a good job in color fidelity, but its clarity still need improvement. Gram-Schmidt transform works best in color fidelity, and the edge of the vegetation is the most obvious, the fused image sharpness is higher than that of principal component analysis. Brovey transform, is suitable for distinguishing the Gram-Schmidt transform, and the most appropriate for GaoFen-1 satellite image in vegetation and non-vegetation area. In brief, different fusion methods have different advantages in image quality and class extraction, and should be used according to the actual application information and image fusion algorithm.

Image databases: Problems and perspectives

NASA Technical Reports Server (NTRS)

Gudivada, V. Naidu

1989-01-01

With the increasing number of computer graphics, image processing, and pattern recognition applications, economical storage, efficient representation and manipulation, and powerful and flexible query languages for retrieval of image data are of paramount importance. These and related issues pertinent to image data bases are examined.

Geometric and perceptual effects of the location of the observer vantage point for linear-perspective images.

PubMed

Todorović, Dejan

2005-01-01

New geometric analyses are presented of three impressive examples of the effects of location of the vantage point on virtual 3-D spaces conveyed by linear-perspective images. In the 'egocentric-road' effect, the perceived direction of the depicted road is always pointed towards the observer, for any position of the vantage point. It is shown that perspective images of real-observer-aimed roads are characterised by a specific, simple pattern of projected side lines. Given that pattern, the position of the observer, and certain assumptions and perspective arguments, the perceived direction of the virtual road towards the observer can be predicted. In the 'skewed balcony' and the 'collapsing ceiling' effects, the position of the vantage point affects the impression of alignment of the virtual architecture conveyed by large-scale illusionistic paintings and the real architecture surrounding them. It is shown that the dislocation of the vantage point away from the viewing position prescribed by the perspective construction induces a mismatch between the painted vanishing point of elements in the picture and the real vanishing point of corresponding elements of the actual architecture. This mismatch of vanishing points provides visual information that the elements of the two architectures are not mutually parallel.

ARC-1994-AC94-0353-2B

NASA Image and Video Library

1994-07-01

Photo Artwork composite by JPL This depiction of comet Shoemaker-Levy 9 impacting Jupiter is shown from several perspectives. IMAGE B shows the perspective from Galileo spacecraft which can observe the impact point directly. For visual appeal, most of the large cometary fragments are shown close to one another in this image. At the time of Jupiter impact, the fragments will be separated from one another by serveral times the distances shown. This image was created by D.A. Seal of JPL's Mission Design Section using orbital computations provIded by P.W. Chodas and D.K. Yeomans of JPL's Navigation Section.

ARC-1994-AC94-0353-2A

NASA Image and Video Library

1994-07-01

Photo Artwork composite by JPL This depiction of comet Shoemaker-Levy 9 impacting Jupiter is shown from several perspectives. IMAGE A is shown from the perspective of Earth based observers. For visual appeal, most of the large cometary fragments are shown close to one another in this image. At the time of Jupiter impact, the fragments will be separated from one another by serveral times the distances shown. This image was created by D.A. Seal of JPL's Mission Design Section using orbital computations provIded by P.W. Chodas and D.K. Yeomans of JPL's Navigation Section.

MO-E-BRD-01: Is Non-Invasive Image-Guided Breast Brachytherapy Good?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hiatt, J.

2015-06-15

Is Non-invasive Image-Guided Breast Brachytherapy Good? – Jess Hiatt, MS Non-invasive Image-Guided Breast Brachytherapy (NIBB) is an emerging therapy for breast boost treatments as well as Accelerated Partial Breast Irradiation (APBI) using HDR surface breast brachytherapy. NIBB allows for smaller treatment volumes while maintaining optimal target coverage. Considering the real-time image-guidance and immobilization provided by the NIBB modality, minimal margins around the target tissue are necessary. Accelerated Partial Breast Irradiation in brachytherapy: is shorter better? - Dorin Todor, PhD VCU A review of balloon and strut devices will be provided together with the origins of APBI: the interstitial multi-catheter implant.more » A dosimetric and radiobiological perspective will help point out the evolution in breast brachytherapy, both in terms of devices and the protocols/clinical trials under which these devices are used. Improvements in imaging, delivery modalities and convenience are among the factors driving the ultrashort fractionation schedules but our understanding of both local control and toxicities associated with various treatments is lagging. A comparison between various schedules, from a radiobiological perspective, will be given together with a critical analysis of the issues. to review and understand the evolution and development of APBI using brachytherapy methods to understand the basis and limitations of radio-biological ‘equivalence’ between fractionation schedules to review commonly used and proposed fractionation schedules Intra-operative breast brachytherapy: Is one stop shopping best?- Bruce Libby, PhD. University of Virginia A review of intraoperative breast brachytherapy will be presented, including the Targit-A and other trials that have used electronic brachytherapy. More modern approaches, in which the lumpectomy procedure is integrated into an APBI workflow, will also be discussed. Learning Objectives: To review past and current clinical trials for IORT To discuss lumpectomy-scan-plan-treat workflow for IORT.« less

MO-E-BRD-03: Intra-Operative Breast Brachytherapy: Is One Stop Shopping Best? [Non-invasive Image-Guided Breast Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Libby, B.

2015-06-15

Is Non-invasive Image-Guided Breast Brachytherapy Good? – Jess Hiatt, MS Non-invasive Image-Guided Breast Brachytherapy (NIBB) is an emerging therapy for breast boost treatments as well as Accelerated Partial Breast Irradiation (APBI) using HDR surface breast brachytherapy. NIBB allows for smaller treatment volumes while maintaining optimal target coverage. Considering the real-time image-guidance and immobilization provided by the NIBB modality, minimal margins around the target tissue are necessary. Accelerated Partial Breast Irradiation in brachytherapy: is shorter better? - Dorin Todor, PhD VCU A review of balloon and strut devices will be provided together with the origins of APBI: the interstitial multi-catheter implant.more » A dosimetric and radiobiological perspective will help point out the evolution in breast brachytherapy, both in terms of devices and the protocols/clinical trials under which these devices are used. Improvements in imaging, delivery modalities and convenience are among the factors driving the ultrashort fractionation schedules but our understanding of both local control and toxicities associated with various treatments is lagging. A comparison between various schedules, from a radiobiological perspective, will be given together with a critical analysis of the issues. to review and understand the evolution and development of APBI using brachytherapy methods to understand the basis and limitations of radio-biological ‘equivalence’ between fractionation schedules to review commonly used and proposed fractionation schedules Intra-operative breast brachytherapy: Is one stop shopping best?- Bruce Libby, PhD. University of Virginia A review of intraoperative breast brachytherapy will be presented, including the Targit-A and other trials that have used electronic brachytherapy. More modern approaches, in which the lumpectomy procedure is integrated into an APBI workflow, will also be discussed. Learning Objectives: To review past and current clinical trials for IORT To discuss lumpectomy-scan-plan-treat workflow for IORT.« less

The Art of Multi-Image.

ERIC Educational Resources Information Center

Gordon, Roger L., Ed.

This guide to multi-image program production for practitioners describes the process from the beginning stages through final presentation, examines historical perspectives, theory, and research in multi-image, and provides examples of successful utilization. Ten chapters focus on the following topics: (1) definition of multi-image field and…

3-D Perspective View, Kamchatka Peninsula, Russia

NASA Image and Video Library

2000-03-23

This perspective view shows the western side of the volcanically active Kamchatka Peninsula in eastern Russia. The image was generated using the first data collected during NASA Shuttle Radar Topography Mission SRTM.

A Warping Framework for Wide-Angle Imaging and Perspective Manipulation

ERIC Educational Resources Information Center

Carroll, Robert E.

2013-01-01

Nearly all photographs are created with lenses that approximate an ideal pinhole camera--that is, a perspective projection. This projection has proven useful not only for creating realistic depictions, but also for its expressive flexibility. Beginning in the Renaissance, the notion of perspective gave artists a systematic way to represent…

Space Radar Image of Mammoth, California in 3-D

NASA Image and Video Library

1999-01-27

This is a three-dimensional perspective of Mammoth Mountain, California. This view was constructed by overlaying a NASA Spaceborne Imaging Radar-C SIR-C radar image on a U.S. Geological Survey digital elevation map.

Training Schrödinger's cat: quantum optimal control. Strategic report on current status, visions and goals for research in Europe

NASA Astrophysics Data System (ADS)

Glaser, Steffen J.; Boscain, Ugo; Calarco, Tommaso; Koch, Christiane P.; Köckenberger, Walter; Kosloff, Ronnie; Kuprov, Ilya; Luy, Burkhard; Schirmer, Sophie; Schulte-Herbrüggen, Thomas; Sugny, Dominique; Wilhelm, Frank K.

2015-12-01

It is control that turns scientific knowledge into useful technology: in physics and engineering it provides a systematic way for driving a dynamical system from a given initial state into a desired target state with minimized expenditure of energy and resources. As one of the cornerstones for enabling quantum technologies, optimal quantum control keeps evolving and expanding into areas as diverse as quantum-enhanced sensing, manipulation of single spins, photons, or atoms, optical spectroscopy, photochemistry, magnetic resonance (spectroscopy as well as medical imaging), quantum information processing and quantum simulation. In this communication, state-of-the-art quantum control techniques are reviewed and put into perspective by a consortium of experts in optimal control theory and applications to spectroscopy, imaging, as well as quantum dynamics of closed and open systems. We address key challenges and sketch a roadmap for future developments.

Spatial judgments in the horizontal and vertical planes from different vantage points.

PubMed

Prytz, Erik; Scerbo, Mark W

2012-01-01

Todorović (2008 Perception 37 106-125) reported that there are systematic errors in the perception of 3-D space when viewing 2-D linear perspective drawings depending on the observer's vantage point. Because these findings were restricted to the horizontal plane, the current study was designed to determine the nature of these errors in the vertical plane. Participants viewed an image containing multiple colonnades aligned on parallel converging lines receding to a vanishing point. They were asked to judge where, in the physical room, the next column should be placed. The results support Todorović in that systematic deviations in the spatial judgments depended on vantage point for both the horizontal and vertical planes. However, there are also marked differences between the two planes. While judgments in both planes failed to compensate adequately for the vantage-point shift, the vertical plane induced greater distortions of the stimulus image itself within each vantage point.

Meteorological Instruction Software

NASA Technical Reports Server (NTRS)

1990-01-01

At Florida State University and the Naval Postgraduate School, meteorology students have the opportunity to apply theoretical studies to current weather phenomena, even prepare forecasts and see how their predictions stand up utilizing GEMPAK. GEMPAK can display data quickly in both conventional and non-traditional ways, allowing students to view multiple perspectives of the complex three-dimensional atmospheric structure. With GEMPAK, mathematical equations come alive as students do homework and laboratory assignments on the weather events happening around them. Since GEMPAK provides data on a 'today' basis, each homework assignment is new. At the Naval Postgraduate School, students are now using electronically-managed environmental data in the classroom. The School's Departments of Meteorology and Oceanography have developed the Interactive Digital Environment Analysis (IDEA) Laboratory. GEMPAK is the IDEA Lab's general purpose display package; the IDEA image processing package is a modified version of NASA's Device Management System. Bringing the graphic and image processing packages together is NASA's product, the Transportable Application Executive (TAE).

Medical photography: current technology, evolving issues and legal perspectives.

PubMed

Harting, M T; DeWees, J M; Vela, K M; Khirallah, R T

2015-04-01

Medical photographic image capture and data management has undergone a rapid and compelling change in complexity over the last 20 years. This is because of multiple factors, including significant advances in ease of photograph capture, alongside an evolution of mechanisms of data portability/dissemination, combined with governmental focus on health information privacy. Literature to guide medical, legal, governmental and business professionals when dealing with issues related to medical photography is virtually nonexistent. Herein, we will address the breadth of uses of medical photography, device properties/specific devices utilised for image capture, methods of data transfer and dissemination and patient perceptions and attitudes regarding photography in a medical setting. In addition, we will address the legal implications, including legal precedent, copyright and privacy law, informed consent, protected health information and the Health Insurance Portability and Accountability Act (HIPAA), as they pertain to medical photography. © 2015 John Wiley & Sons Ltd.

Spirit's Travels During its First 238 Martian Days

NASA Technical Reports Server (NTRS)

2004-01-01

This map shows the complete traverse of NASA's Mars Exploration Rover Spirit through the rover's 238th martian day, or sol (Sept. 3, 2004). This was shortly before the rover stopped driving for about two weeks while Mars was nearly behind the Sun from Earth's perspective. The background image consists of frames from the Mars Orbiter Camera on NASA's Mars Global Surveyor orbiter. Inset images along the route are from Spirit's navigation camera. From its landing site, Spirit drove up to the rim of 'Bonneville' crater on the far left and to the north rim of 'Missoula' crater. Then it commenced a long drive across the plains, deviating to avoid large hollows. Upon arrival at the base of the 'Columbia Hills,' Spirit drove north for a short distance before beginning its ascent onto the 'West Spur,' where it is currently located. The scale bar at lower left is 500 meters (1,640 feet). North is up.

Perspectives for the Use of Social Media in e-Pharmamarketing

PubMed Central

Syrkiewicz-Świtała, Magdalena; Romaniuk, Piotr; Ptak, Ewa

2016-01-01

The Internet has become a common and global medium. It contains vast information resources and a wide range of communication instruments. One of the communication channels are social media, which increasingly are also used in the business field. Social media combined with mobile technology introduced new challenges to marketing activity. This trend is also observed on specific and highly regulated drug market. The aim of this article is to describe the perspectives for the use of social media in e-pharmamarketing. We find that this require personalized communication, the use of online promotion tools, in order to perform advertising in contact with a demanding client. Currently pharmaceutical companies use social media to communicate basic information on their life, but they still do not appreciate it sufficiently as a tool to build the image of company or products. It is therefore considered that these companies should attach greater importance to the presence in this type of media, especially in the light of dynamic changes in the way people communicate. PMID:27917126

Perspectives for the Use of Social Media in e-Pharmamarketing.

PubMed

Syrkiewicz-Świtała, Magdalena; Romaniuk, Piotr; Ptak, Ewa

2016-01-01

The Internet has become a common and global medium. It contains vast information resources and a wide range of communication instruments. One of the communication channels are social media, which increasingly are also used in the business field. Social media combined with mobile technology introduced new challenges to marketing activity. This trend is also observed on specific and highly regulated drug market. The aim of this article is to describe the perspectives for the use of social media in e-pharmamarketing. We find that this require personalized communication, the use of online promotion tools, in order to perform advertising in contact with a demanding client. Currently pharmaceutical companies use social media to communicate basic information on their life, but they still do not appreciate it sufficiently as a tool to build the image of company or products. It is therefore considered that these companies should attach greater importance to the presence in this type of media, especially in the light of dynamic changes in the way people communicate.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hale, M.A.; Craig, J.I.

Integrated Product and Process Development (IPPD) embodies the simultaneous application to both system and quality engineering methods throughout an iterative design process. The use of IPPD results in the time-conscious, cost-saving development of engineering systems. To implement IPPD, a Decision-Based Design perspective is encapsulated in an approach that focuses on the role of the human designer in product development. The approach has two parts and is outlined in this paper. First, an architecture, called DREAMS, is being developed that facilitates design from a decision-based perspective. Second, a supporting computing infrastructure, called IMAGE, is being designed. Agents are used to implementmore » the overall infrastructure on the computer. Successful agent utilization requires that they be made of three components: the resource, the model, and the wrap. Current work is focused on the development of generalized agent schemes and associated demonstration projects. When in place, the technology independent computing infrastructure will aid the designer in systematically generating knowledge used to facilitate decision-making.« less

Use of agents to implement an integrated computing environment

NASA Technical Reports Server (NTRS)

Hale, Mark A.; Craig, James I.

1995-01-01

Integrated Product and Process Development (IPPD) embodies the simultaneous application to both system and quality engineering methods throughout an iterative design process. The use of IPPD results in the time-conscious, cost-saving development of engineering systems. To implement IPPD, a Decision-Based Design perspective is encapsulated in an approach that focuses on the role of the human designer in product development. The approach has two parts and is outlined in this paper. First, an architecture, called DREAMS, is being developed that facilitates design from a decision-based perspective. Second, a supporting computing infrastructure, called IMAGE, is being designed. Agents are used to implement the overall infrastructure on the computer. Successful agent utilization requires that they be made of three components: the resource, the model, and the wrap. Current work is focused on the development of generalized agent schemes and associated demonstration projects. When in place, the technology independent computing infrastructure will aid the designer in systematically generating knowledge used to facilitate decision-making.

State of the Art for Deep Brain Stimulation Therapy in Movement Disorders: A Clinical and Technological Perspective.

PubMed

Wagle Shukla, Aparna; Okun, Michael S

2016-01-01

Deep brain stimulation (DBS) therapy is a widely used brain surgery that can be applied for many neurological and psychiatric disorders. DBS is American Food and Drug Administration approved for medication refractory Parkinson's disease, essential tremor and dystonia. Although DBS has shown consistent success in many clinical trials, the therapy has limitations and there are well-recognized complications. Thus, only carefully selected patients are ideal candidates for this surgery. Over the last two decades, there have been significant advances in clinical knowledge on DBS. In addition, the surgical techniques and technology related to DBS has been rapidly evolving. The goal of this review is to describe the current status of DBS in the context of movement disorders, outline the mechanisms of action for DBS in brief, discuss the standard surgical and imaging techniques, discuss the patient selection and clinical outcomes in each of the movement disorders, and finally, introduce the recent advancements from a clinical and technological perspective.

A Hydrological Perspective to Advance Understanding of the Water Cycle

NASA Astrophysics Data System (ADS)

Berghuijs, W.

2014-12-01

In principle hydrologists are scientists that study relationships within the water cycle. Yet, current technology makes it tempting for hydrology students to lose their "hydrological perspective" and become instead full-time computer programmers or statisticians. I assert that students should ensure their hydrological perspective thrives, notwithstanding the importance and possibilities of current technology. This perspective is necessary to advance the science of hydrology. As other hydrologists have pondered similar views before, I make no claims of originality here. I just hope that in presenting my perspective on this issue I may spark the interest of other early career hydrologists.

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications.

PubMed

Han, Ya-Hui; Kankala, Ranjith Kumar; Wang, Shi-Bin; Chen, Ai-Zheng

2018-05-24

In recent times, photo-induced therapeutics have attracted enormous interest from researchers due to such attractive properties as preferential localization, excellent tissue penetration, high therapeutic efficacy, and minimal invasiveness, among others. Numerous photosensitizers have been considered in combination with light to realize significant progress in therapeutics. Along this line, indocyanine green (ICG), a Food and Drug Administration (FDA)-approved near-infrared (NIR, >750 nm) fluorescent dye, has been utilized in various biomedical applications such as drug delivery, imaging, and diagnosis, due to its attractive physicochemical properties, high sensitivity, and better imaging view field. However, ICG still suffers from certain limitations for its utilization as a molecular imaging probe in vivo, such as concentration-dependent aggregation, poor in vitro aqueous stability and photodegradation due to various physicochemical attributes. To overcome these limitations, much research has been dedicated to engineering numerous multifunctional polymeric composites for potential biomedical applications. In this review, we aim to discuss ICG-encapsulated polymeric nanoconstructs, which are of particular interest in various biomedical applications. First, we emphasize some attractive properties of ICG (including physicochemical characteristics, optical properties, metabolic features, and other aspects) and some of its current limitations. Next, we aim to provide a comprehensive overview highlighting recent reports on various polymeric nanoparticles that carry ICG for light-induced therapeutics with a set of examples. Finally, we summarize with perspectives highlighting the significant outcome, and current challenges of these nanocomposites.

Vertical viewing angle enhancement for the 360  degree integral-floating display using an anamorphic optic system.

PubMed

Erdenebat, Munkh-Uchral; Kwon, Ki-Chul; Yoo, Kwan-Hee; Baasantseren, Ganbat; Park, Jae-Hyeung; Kim, Eun-Soo; Kim, Nam

2014-04-15

We propose a 360 degree integral-floating display with an enhanced vertical viewing angle. The system projects two-dimensional elemental image arrays via a high-speed digital micromirror device projector and reconstructs them into 3D perspectives with a lens array. Double floating lenses relate initial 3D perspectives to the center of a vertically curved convex mirror. The anamorphic optic system tailors the initial 3D perspectives horizontally and vertically disperse light rays more widely. By the proposed method, the entire 3D image provides both monocular and binocular depth cues, a full-parallax demonstration with high-angular ray density and an enhanced vertical viewing angle.

The use of preferred social stimuli as rewards for rhesus macaques in behavioural neuroscience

PubMed Central

Pearce, Bradley; Thiele, Alexander; Rowe, Candy

2017-01-01

Macaques are often motivated to perform in neuroscientific experiments by implementing fluid restriction protocols. Daily access to water is controlled and the monkeys are rewarded with droplets of fluid for performing correct trials in the laboratory. Although these protocols are widely used and highly effective, it is important from a 3Rs perspective to investigate refinements that may help to lessen the severity of the fluid restriction applied. We assessed the use of social stimuli (images of conspecifics) as rewards for four rhesus macaques performing simple cognitive tasks. We found that individual preferences for images of male faces, female perinea and control stimuli could be identified in each monkey. However, using preferred images did not translate into effective motivators on a trial-by-trial basis: animals preferred fluid rewards, even when fluid restriction was relaxed. There was no difference in the monkeys’ performance of a task when using greyscale versus colour images. Based on our findings, we cannot recommend the use of social stimuli, in this form, as a refinement to current fluid restriction protocols. We discuss the potential alternatives and possibilities for future research. PMID:28542356

Image processing and 3D visualization in the interpretation of patterned injury of the skin

NASA Astrophysics Data System (ADS)

Oliver, William R.; Altschuler, Bruce R.

1995-09-01

The use of image processing is becoming increasingly important in the evaluation of violent crime. While much work has been done in the use of these techniques for forensic purposes outside of forensic pathology, its use in the pathologic examination of wounding has been limited. We are investigating the use of image processing in the analysis of patterned injuries and tissue damage. Our interests are currently concentrated on 1) the use of image processing techniques to aid the investigator in observing and evaluating patterned injuries in photographs, 2) measurement of the 3D shape characteristics of surface lesions, and 3) correlation of patterned injuries with deep tissue injury as a problem in 3D visualization. We are beginning investigations in data-acquisition problems for performing 3D scene reconstructions from the pathology perspective of correlating tissue injury to scene features and trace evidence localization. Our primary tool for correlation of surface injuries with deep tissue injuries has been the comparison of processed surface injury photographs with 3D reconstructions from antemortem CT and MRI data. We have developed a prototype robot for the acquisition of 3D wound and scene data.

Three dimensional perspective view of false-color image of eastern Hawaii

NASA Technical Reports Server (NTRS)

1994-01-01

This is a three dimensional perspective view of false-color image of the eastern part of the Big Island of Hawaii. It was produced using all three radar frequencies C-Band and L-Band. This view was constructed by overlaying a SIR-C radar image on a U.S. Geological Survey digital elevation map. The image was acquired on April 12, 1994 during the 52nd orbit of the Shuttle Endeavour by the Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR). The area shown is approximately 34 by 57 kilomters with the top of the image pointing toward north-west. The image is centered at about 155.25 degrees west longitude and 19.5 degrees north latitude. Visible in the center of the image in blue are the summit crater (Kilauea Caidera) which contains the smaller Halemaumau Crater, and the line of collapsed craters below them that form the Chain of Craters Road. The rain forest appears bright in the image while green areas correspond to lower vegetation. The lava flows have differen

A global perspective on mechanical prosthetic heart valve thrombosis: Diagnostic and therapeutic challenges

PubMed Central

Gürsoy, Mustafa Ozan; Kalçık, Macit; Yesin, Mahmut; Karakoyun, Süleyman; Bayam, Emrah; Gündüz, Sabahattin; Özkan, Mehmet

2016-01-01

Prosthetic valve thrombosis is one of the major causes of primary valve failure, which can be life-threatening. Multimodality imaging is necessary for determination of leaflet immobilization, cause of underlying pathology (thrombus versus pannus or both), and whether thrombolytic therapy attempt in the patient would be successful or surgery is needed. Current guidelines for the management of prosthetic valve thrombosis lack definitive class I recommendations due to lack of randomized controlled trials, and usually leave the choice of treatment to the clinician’s experience. In this review, we aimed to summarize the pathogenesis, diagnosis, and management of mechanical prosthetic valve thrombosis. PMID:28005024

Transformation-aware perceptual image metric

NASA Astrophysics Data System (ADS)

Kellnhofer, Petr; Ritschel, Tobias; Myszkowski, Karol; Seidel, Hans-Peter

2016-09-01

Predicting human visual perception has several applications such as compression, rendering, editing, and retargeting. Current approaches, however, ignore the fact that the human visual system compensates for geometric transformations, e.g., we see that an image and a rotated copy are identical. Instead, they will report a large, false-positive difference. At the same time, if the transformations become too strong or too spatially incoherent, comparing two images gets increasingly difficult. Between these two extrema, we propose a system to quantify the effect of transformations, not only on the perception of image differences but also on saliency and motion parallax. To this end, we first fit local homographies to a given optical flow field, and then convert this field into a field of elementary transformations, such as translation, rotation, scaling, and perspective. We conduct a perceptual experiment quantifying the increase of difficulty when compensating for elementary transformations. Transformation entropy is proposed as a measure of complexity in a flow field. This representation is then used for applications, such as comparison of nonaligned images, where transformations cause threshold elevation, detection of salient transformations, and a model of perceived motion parallax. Applications of our approach are a perceptual level-of-detail for real-time rendering and viewpoint selection based on perceived motion parallax.

Hybrid imaging worldwide-challenges and opportunities for the developing world: a report of a Technical Meeting organized by IAEA.

PubMed

Kashyap, Ravi; Dondi, Maurizio; Paez, Diana; Mariani, Guliano

2013-05-01

The growth in nuclear medicine, in the past decade, is largely due to hybrid imaging, specifically single-photon emission tomography-computed tomography (SPECT-CT) and positron emission tomography-computed tomography (PET-CT). Introduction and use of hybrid imaging has been growing at a fast pace. This has led to many challenges and opportunities to the personnel dealing with it. The International Atomic Energy Agency (IAEA) keeps a close watch on the trends in applications of nuclear techniques in health by many ways, including obtaining inputs from member states and professional societies. In 2012, a Technical Meeting on trends in hybrid imaging was organized by IAEA to understand the current status and trends of hybrid imaging using nuclear techniques, its role in clinical practice, and associated educational needs and challenges. Perspective of scientific societies and professionals from all the regions of the world was obtained. Heterogeneity in value, educational needs, and access was noted and the drivers of this heterogeneity were discussed. This article presents the key points shared during the technical meeting, focusing primarily on SPECT-CT and PET-CT, and shares the action plan for IAEA to deal with heterogeneity as suggested by the participants. Copyright © 2013 Elsevier Inc. All rights reserved.

Positive body image: inter-ethnic and rural-urban differences among an indigenous sample from Malaysian Borneo.

PubMed

Swami, Viren; Kannan, Kumaraswami; Furnham, Adrian

2012-11-01

Previous studies examining body image from a cross-cultural perspective have tended to neglect samples from different ethnic groups or along a rural-urban continuum. To overcome this limitation, the present study examined positive body image among rural and urban women from three major indigenous ethnic groups in Sabah, Malaysia. A total of 202 women completed the Body Appreciation Scale, as well as measures of media exposure and financial security, and provided their demographic details. s showed that there were significant rural-urban differences in body appreciation, with rural participants having significantly higher body appreciation than urban participants. A comparison with a previous data set of West Malaysian women (Swami & Chamorro-Premuzic, 2008) showed that the current urban sample had significantly lower body appreciation and that the rural group had significantly higher body appreciation. Further results showed that research site (urban vs rural) explained 11.0% of the variance in body appreciation. Participant body mass index and exposure to western forms of media explained an additional 2.0% of the variance. These results suggest that there are differences in body image between rural and urban women. Results are discussed in relation to the promotion of positive body image, particularly in developing societies where health care resources may be limited.

Vision 20/20: Simultaneous CT-MRI — Next chapter of multimodality imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Ge, E-mail: wangg6@rpi.edu; Xi, Yan; Gjesteby, Lars

Multimodality imaging systems such as positron emission tomography-computed tomography (PET-CT) and MRI-PET are widely available, but a simultaneous CT-MRI instrument has not been developed. Synergies between independent modalities, e.g., CT, MRI, and PET/SPECT can be realized with image registration, but such postprocessing suffers from registration errors that can be avoided with synchronized data acquisition. The clinical potential of simultaneous CT-MRI is significant, especially in cardiovascular and oncologic applications where studies of the vulnerable plaque, response to cancer therapy, and kinetic and dynamic mechanisms of targeted agents are limited by current imaging technologies. The rationale, feasibility, and realization of simultaneous CT-MRImore » are described in this perspective paper. The enabling technologies include interior tomography, unique gantry designs, open magnet and RF sequences, and source and detector adaptation. Based on the experience with PET-CT, PET-MRI, and MRI-LINAC instrumentation where hardware innovation and performance optimization were instrumental to construct commercial systems, the authors provide top-level concepts for simultaneous CT-MRI to meet clinical requirements and new challenges. Simultaneous CT-MRI fills a major gap of modality coupling and represents a key step toward the so-called “omnitomography” defined as the integration of all relevant imaging modalities for systems biology and precision medicine.« less

Outstanding Issues and Future Directions of Inner Magnetospheric Research (Invited)

NASA Astrophysics Data System (ADS)

Brandt, P. C.

2009-12-01

Several research areas of the inner magnetosphere and ionosphere (MI) system have reached a state, where the coupling mechanisms can no longer be treated as boundary conditions or ad-hoc assumptions in our physical models. It is nothing new that our community has become increasingly aware of the necessity to use global measurements from multiple observation platforms and missions, in order to understand both the system as a whole as well as its individual subsystems. In this presentation we briefly review the current status and outstanding issues of inner MI research. We attempt to establish a working definition of the term "Systems Approach", then present observational tools and techniques that enable such an approach. Physical modeling plays a central role not only in understanding the mechanisms at work, but also in determining the key quantities to be measured. We conclude by discussing questions relevant to future directions. Are there new techniques that need more attention? Should multi-platform observations be included as a default component already at the mission-level in the future? Is solar minimum uninteresting from an MI perspective? Should we actively compare to magnetospheres of other planets? Examples of outstanding issues in inner MI research include the circulation of ionospheric plasma from low to high latitudes and its escape to the magnetosphere, where it is energized by magnetospheric processes and becomes a part of the plasma pressure that in turn affects the ionospheric and magnetospheric electric field. The electric field, in turn, plays a controlling role in the transport of both magnetospheric and ionospheric plasma, which is intimately linked with ionospheric conductance. The conductance, in turn, is controlled by thermospheric chemistry coupled with plasma flow and heating and magnetospheric precipitation and Joule heating. Several techniques have emerged as important tools: auroral imaging, inversions of ENA images to retrieve the plasma pressure distribution and the associated currents (example: IMAGE and stereo imaging from TWINS), EUV imaging to retrieve the global plasmaspheric dynamics (example: IMAGE), magnetospheric magnetic field measurements to reconstruct the global dynamics of the magnetic field and current systems (example: TS07d), global networks of radar measurements of ionospheric flows (example: superDarn), tomographic inversion of GPS signal measurements to reconstruct 3D electron density profiles (example: COSMIC), low-altitude magnetic field measurements to derive maps of field-aligned currents (example: Iridium and AMPERE).

A feminist perspective on sexuality and body image in females with colorectal cancer: an integrative review.

PubMed

Li, Chia-Chun; Rew, Lynn

2010-01-01

Women often experience sexual dysfunction following colorectal cancer surgery. The purpose of this integrative review is to explore changes in body image and sexuality associated with colorectal cancer and its treatment in women. We used a feminist perspective to explore differences in gender role, in body image, and sexuality in the context of women who are treated for colorectal cancer. Results of our review suggest that additional studies and interventions are needed to better understand and assist women with sexual dysfunction associated with colorectal cancer. Research should focus on how age, physical, psychosocial factors influence sexual function in particular.

Advantages and Disadvantages in Image Processing with Free Software in Radiology.

PubMed

Mujika, Katrin Muradas; Méndez, Juan Antonio Juanes; de Miguel, Andrés Framiñan

2018-01-15

Currently, there are sophisticated applications that make it possible to visualize medical images and even to manipulate them. These software applications are of great interest, both from a teaching and a radiological perspective. In addition, some of these applications are known as Free Open Source Software because they are free and the source code is freely available, and therefore it can be easily obtained even on personal computers. Two examples of free open source software are Osirix Lite® and 3D Slicer®. However, this last group of free applications have limitations in its use. For the radiological field, manipulating and post-processing images is increasingly important. Consequently, sophisticated computing tools that combine software and hardware to process medical images are needed. In radiology, graphic workstations allow their users to process, review, analyse, communicate and exchange multidimensional digital images acquired with different image-capturing radiological devices. These radiological devices are basically CT (Computerised Tomography), MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography), etc. Nevertheless, the programs included in these workstations have a high cost which always depends on the software provider and is always subject to its norms and requirements. With this study, we aim to present the advantages and disadvantages of these radiological image visualization systems in the advanced management of radiological studies. We will compare the features of the VITREA2® and AW VolumeShare 5® radiology workstation with free open source software applications like OsiriX® and 3D Slicer®, with examples from specific studies.

NASA Spacecraft Captures Image of Brazil Flooding

NASA Image and Video Library

2011-01-19

On Jan. 18, 2011, NASA Terra spacecraft captured this 3-D perspective image of the city of Nova Friburgo, Brazil. A week of torrential rains triggered a series of deadly mudslides and floods. More details about this image at the Photojournal.

Targeted Nanoparticles for Image-guided Treatment of Triple Negative Breast Cancer: Clinical Significance and Technological Advances

PubMed Central

Miller-Kleinhenz, Jasmine M.; Bozeman, Erica N.

2015-01-01

Effective treatment of triple negative breast cancer (TNBC) with its aggressive tumor biology, highly heterogeneous tumor cells, and poor prognosis requires an integrated therapeutic approach that addresses critical issues in cancer therapy. Multifunctional nanoparticles with the abilities of targeted drug delivery and non-invasive imaging for monitoring drug delivery and responses to therapy, such as theranostic nanoparticles, hold great promise towards the development of novel therapeutic approaches for the treatment of TNBC using a single therapeutic platform. The biological and pathological characteristics of TNBC provide insight into several potential molecular targets for current and future nanoparticle based therapeutics. Extensive tumor stroma, highly proliferative cells, and a high rate of drug-resistance are all barriers that must be appropriately addressed in order for these nanotherapeutic platforms to be effective. Utilization of the enhanced permeability and retention (EPR) effect coupled with active targeting of cell surface receptors expressed by TNBC cells, and tumor associated endothelial cells, stromal fibroblasts and macrophages is likely to overcome such barriers to facilitate more effective drug delivery. An in depth summary of current studies investigating targeted nanoparticles in preclinical TNBC mouse and human xenograft models is presented. This review aims to outline the current status of nanotherapeutic options for TNBC patients, identification of promising molecular targets, challenges associated with the development of targeted nanotherapeutics, the research done by our group as well as others and future perspectives on the nanomedicine field and ways to translate current preclinical studies into the clinic. PMID:25966677

Perspective View of Umnak Island, Aleutian Islands, Alaska #2

NASA Image and Video Library

2001-11-04

This image is a perspective view acquired by NASA Airborne Synthetic Aperture Radar AIRSAR in 2001, is of Umnak Island, one of Alaska Aleutian Islands. The active Okmok volcano appears in the center of the island.

Perspective View of Umnak Island, Aleutian Islands, Alaska #1

NASA Image and Video Library

2001-11-04

This image is a perspective view acquired by NASA Airborne Synthetic Aperture Radar AIRSAR in 2001, is of Umnak Island, one of Alaska Aleutian Islands. The active Okmok volcano appears in the center of the island.

SRTM Perspective View with Landsat Overlay: Santa Paula, and Santa Clara River Valley, California

NASA Image and Video Library

2000-12-14

Rectangular fields of the agriculturally rich Santa Clara River Valley are visible in this perspective view generated by using data from the Shuttle Radar Topography Mission and an enhanced Landsat image.

We get the algorithms of our ground truths: Designing referential databases in digital image processing

PubMed Central

Jaton, Florian

2017-01-01

This article documents the practical efforts of a group of scientists designing an image-processing algorithm for saliency detection. By following the actors of this computer science project, the article shows that the problems often considered to be the starting points of computational models are in fact provisional results of time-consuming, collective and highly material processes that engage habits, desires, skills and values. In the project being studied, problematization processes lead to the constitution of referential databases called ‘ground truths’ that enable both the effective shaping of algorithms and the evaluation of their performances. Working as important common touchstones for research communities in image processing, the ground truths are inherited from prior problematization processes and may be imparted to subsequent ones. The ethnographic results of this study suggest two complementary analytical perspectives on algorithms: (1) an ‘axiomatic’ perspective that understands algorithms as sets of instructions designed to solve given problems computationally in the best possible way, and (2) a ‘problem-oriented’ perspective that understands algorithms as sets of instructions designed to computationally retrieve outputs designed and designated during specific problematization processes. If the axiomatic perspective on algorithms puts the emphasis on the numerical transformations of inputs into outputs, the problem-oriented perspective puts the emphasis on the definition of both inputs and outputs. PMID:28950802

Perspective View with Landsat Overlay, Sacramento, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

California's state capitol, Sacramento, can be seen clustered along the American and Sacramento Rivers in this computer-generated perspective viewed from the west. Folsom Lake is in the center and the Sierra Nevada is above, with the edge of Lake Tahoe just visible at top center.

This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced color Landsat 5satellite image. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR)that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

Size: scale varies in this perspective image Location: 38.6 deg. North lat., 121.3 deg. West lon. Orientation: looking east Image Data: Landsat Bands 3, 2, 1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet), Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Perspective View with Landsat Overlay, Mount Shasta, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

At more than 4,300 meters (14,000 feet ), Mount Shasta is California's tallest volcano and part of the Cascade chain of volcanoes extending south from Washington. This computer-generated perspective viewed from the west also includes Shastina, a slightly smaller volcanic cone left of Shasta's summit and Black Butte, another volcano in the right foreground.

This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced color Landsat 5satellite image. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR)that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise,Washington, D.C.

Size: scale varies in this perspective image Location: 41.4 deg. North lat., 122.3 deg. West lon. Orientation: looking east Image Data: Landsat Bands 3,2,1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet), Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Kinder, gentler stereo

NASA Astrophysics Data System (ADS)

Siegel, Mel; Tobinaga, Yoshikazu; Akiya, Takeo

1999-05-01

Not only binocular perspective disparity, but also many secondary binocular and monocular sensory phenomena, contribute to the human sensation of depth. Binocular perspective disparity is notable as the strongest depth perception factor. However means for creating if artificially from flat image pairs are notorious for inducing physical and mental stresses, e.g., 'virtual reality sickness'. Aiming to deliver a less stressful 'kinder gentler stereo (KGS)', we systematically examine the secondary phenomena and their synergistic combination with each other and with binocular perspective disparity. By KGS we mean a stereo capture, rendering, and display paradigm without cue conflicts, without eyewear, without viewing zones, with negligible 'lock-in' time to perceive the image in depth, and with a normal appearance for stereo-deficient viewers. To achieve KGS we employ optical and digital image processing steps that introduce distortions contrary to strict 'geometrical correctness' of binocular perspective but which nevertheless result in increased stereoscopic viewing comfort. We particularly exploit the lower limits of interoccular separation, showing that unexpectedly small disparities stimulate accurate and pleasant depth sensations. Under these circumstances crosstalk is perceived as depth-of-focus rather than as ghosting. This suggests the possibility of radically new approaches to stereoview multiplexing that enable zoneless autostereoscopic display.

Progress in 3D imaging and display by integral imaging

NASA Astrophysics Data System (ADS)

Martinez-Cuenca, R.; Saavedra, G.; Martinez-Corral, M.; Pons, A.; Javidi, B.

2009-05-01

Three-dimensionality is currently considered an important added value in imaging devices, and therefore the search for an optimum 3D imaging and display technique is a hot topic that is attracting important research efforts. As main value, 3D monitors should provide the observers with different perspectives of a 3D scene by simply varying the head position. Three-dimensional imaging techniques have the potential to establish a future mass-market in the fields of entertainment and communications. Integral imaging (InI), which can capture true 3D color images, has been seen as the right technology to 3D viewing to audiences of more than one person. Due to the advanced degree of development, InI technology could be ready for commercialization in the coming years. This development is the result of a strong research effort performed along the past few years by many groups. Since Integral Imaging is still an emerging technology, the first aim of the "3D Imaging and Display Laboratory" at the University of Valencia, has been the realization of a thorough study of the principles that govern its operation. Is remarkable that some of these principles have been recognized and characterized by our group. Other contributions of our research have been addressed to overcome some of the classical limitations of InI systems, like the limited depth of field (in pickup and in display), the poor axial and lateral resolution, the pseudoscopic-to-orthoscopic conversion, the production of 3D images with continuous relief, or the limited range of viewing angles of InI monitors.

TU-C-201-02: Clinical Implementation of HDR: Afterloader and Applicator Selection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esthappan, J.

2015-06-15

Recent use of HDR has increased while planning has become more complex often necessitating 3D image-based planning. While many guidelines for the use of HDR exist, they have not kept pace with the increased complexity of 3D image-based planning. Furthermore, no comprehensive document exists to describe the wide variety of current HDR clinical indications. This educational session aims to summarize existing national and international guidelines for the safe implementation of an HDR program. A summary of HDR afterloaders available on the market and their existing applicators will be provided, with guidance on how to select the best fit for eachmore » institution’s needs. Finally, the use of checklists will be discussed as a means to implement a safe and efficient HDR program and as a method by which to verify the quality of an existing HDR program. This session will provide the perspective of expert HDR physicists as well as the perspective of a new HDR user. Learning Objectives: Summarize national and international safety and staffing guidelines for HDR implementation Discuss the process of afterloader and applicator selection for gynecologic, prostate, breast, interstitial, surface treatments Learn about the use of an audit checklist tool to measure of quality control of a new or existing HDR program Describe the evolving use of checklists within an HDR program.« less

TU-C-201-00: Clinical Implementation of HDR Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2015-06-15

Recent use of HDR has increased while planning has become more complex often necessitating 3D image-based planning. While many guidelines for the use of HDR exist, they have not kept pace with the increased complexity of 3D image-based planning. Furthermore, no comprehensive document exists to describe the wide variety of current HDR clinical indications. This educational session aims to summarize existing national and international guidelines for the safe implementation of an HDR program. A summary of HDR afterloaders available on the market and their existing applicators will be provided, with guidance on how to select the best fit for eachmore » institution’s needs. Finally, the use of checklists will be discussed as a means to implement a safe and efficient HDR program and as a method by which to verify the quality of an existing HDR program. This session will provide the perspective of expert HDR physicists as well as the perspective of a new HDR user. Learning Objectives: Summarize national and international safety and staffing guidelines for HDR implementation Discuss the process of afterloader and applicator selection for gynecologic, prostate, breast, interstitial, surface treatments Learn about the use of an audit checklist tool to measure of quality control of a new or existing HDR program Describe the evolving use of checklists within an HDR program.« less

TU-C-201-03: The Use of Checklists and Audit Tools for Safety and QA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prisciandaro, J.

Recent use of HDR has increased while planning has become more complex often necessitating 3D image-based planning. While many guidelines for the use of HDR exist, they have not kept pace with the increased complexity of 3D image-based planning. Furthermore, no comprehensive document exists to describe the wide variety of current HDR clinical indications. This educational session aims to summarize existing national and international guidelines for the safe implementation of an HDR program. A summary of HDR afterloaders available on the market and their existing applicators will be provided, with guidance on how to select the best fit for eachmore » institution’s needs. Finally, the use of checklists will be discussed as a means to implement a safe and efficient HDR program and as a method by which to verify the quality of an existing HDR program. This session will provide the perspective of expert HDR physicists as well as the perspective of a new HDR user. Learning Objectives: Summarize national and international safety and staffing guidelines for HDR implementation Discuss the process of afterloader and applicator selection for gynecologic, prostate, breast, interstitial, surface treatments Learn about the use of an audit checklist tool to measure of quality control of a new or existing HDR program Describe the evolving use of checklists within an HDR program.« less

Current perspectives in the use of molecular imaging to target surgical treatments for genitourinary cancers.

PubMed

Greco, Francesco; Cadeddu, Jeffrey A; Gill, Inderbir S; Kaouk, Jihad H; Remzi, Mesut; Thompson, R Houston; van Leeuwen, Fijs W B; van der Poel, Henk G; Fornara, Paolo; Rassweiler, Jens

2014-05-01

Molecular imaging (MI) entails the visualisation, characterisation, and measurement of biologic processes at the molecular and cellular levels in humans and other living systems. Translating this technology to interventions in real-time enables interventional MI/image-guided surgery, for example, by providing better detection of tumours and their dimensions. To summarise and critically analyse the available evidence on image-guided surgery for genitourinary (GU) oncologic diseases. A comprehensive literature review was performed using PubMed and the Thomson Reuters Web of Science. In the free-text protocol, the following terms were applied: molecular imaging, genitourinary oncologic surgery, surgical navigation, image-guided surgery, and augmented reality. Review articles, editorials, commentaries, and letters to the editor were included if deemed to contain relevant information. We selected 79 articles according to the search strategy based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis criteria and the IDEAL method. MI techniques included optical imaging and fluorescent techniques, the augmented reality (AR) navigation system, magnetic resonance imaging spectroscopy, positron emission tomography, and single-photon emission computed tomography. Experimental studies on the AR navigation system were restricted to the detection and therapy of adrenal and renal malignancies and in the relatively infrequent cases of prostate cancer, whereas fluorescence techniques and optical imaging presented a wide application of intraoperative GU oncologic surgery. In most cases, image-guided surgery was shown to improve the surgical resectability of tumours. Based on the evidence to date, image-guided surgery has promise in the near future for multiple GU malignancies. Further optimisation of targeted imaging agents, along with the integration of imaging modalities, is necessary to further enhance intraoperative GU oncologic surgery. Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.

MO-A-BRD-02: Physics Perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kappadath, S.

2015-06-15

Yttrium-90 (Y90) microsphere therapy, a form of radiation therapy, is an increasingly popular option for care of patients with liver metastases or unresectable hepatocellular carcinoma. The therapy directly delivers Y90 microspheres via the hepatic artery to disease sites. Following delivery, a vast majority of microspheres preferentially lodge in the capillary vessels due to their embolic size and targeted trans-arterial delivery – depositing up to 90% of its energy in the first 5 mm of tissue. There have been a number of advances in tomographic imaging within both interventional radiology and nuclear medicine that has advanced therapy planning techniques. Quantitative imagingmore » of Y90 microsphere distribution post-therapy has also seen innovations that have led to improvements in tumor dosimetry and characterization of tumor response. A review of current trends and recent innovation in Y90 microsphere therapies will be presented. Learning Objectives: To present the imaging requirements for Y90 microsphere therapy planning To explain the standard dosimetry models used in Y90 microsphere therapy planning To report on advances in imaging for therapy planning and posttherapy assessment of tumor dosimetry and response.« less

MO-A-BRD-01: Clinical Perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahvash, A.

2015-06-15

Yttrium-90 (Y90) microsphere therapy, a form of radiation therapy, is an increasingly popular option for care of patients with liver metastases or unresectable hepatocellular carcinoma. The therapy directly delivers Y90 microspheres via the hepatic artery to disease sites. Following delivery, a vast majority of microspheres preferentially lodge in the capillary vessels due to their embolic size and targeted trans-arterial delivery – depositing up to 90% of its energy in the first 5 mm of tissue. There have been a number of advances in tomographic imaging within both interventional radiology and nuclear medicine that has advanced therapy planning techniques. Quantitative imagingmore » of Y90 microsphere distribution post-therapy has also seen innovations that have led to improvements in tumor dosimetry and characterization of tumor response. A review of current trends and recent innovation in Y90 microsphere therapies will be presented. Learning Objectives: To present the imaging requirements for Y90 microsphere therapy planning To explain the standard dosimetry models used in Y90 microsphere therapy planning To report on advances in imaging for therapy planning and posttherapy assessment of tumor dosimetry and response.« less

Quantitative Aspects of Single Molecule Microscopy

PubMed Central

Ober, Raimund J.; Tahmasbi, Amir; Ram, Sripad; Lin, Zhiping; Ward, E. Sally

2015-01-01

Single molecule microscopy is a relatively new optical microscopy technique that allows the detection of individual molecules such as proteins in a cellular context. This technique has generated significant interest among biologists, biophysicists and biochemists, as it holds the promise to provide novel insights into subcellular processes and structures that otherwise cannot be gained through traditional experimental approaches. Single molecule experiments place stringent demands on experimental and algorithmic tools due to the low signal levels and the presence of significant extraneous noise sources. Consequently, this has necessitated the use of advanced statistical signal and image processing techniques for the design and analysis of single molecule experiments. In this tutorial paper, we provide an overview of single molecule microscopy from early works to current applications and challenges. Specific emphasis will be on the quantitative aspects of this imaging modality, in particular single molecule localization and resolvability, which will be discussed from an information theoretic perspective. We review the stochastic framework for image formation, different types of estimation techniques and expressions for the Fisher information matrix. We also discuss several open problems in the field that demand highly non-trivial signal processing algorithms. PMID:26167102

Three Dimensional Optical Coherence Tomography Imaging: Advantages and Advances

PubMed Central

Gabriele, Michelle L; Wollstein, Gadi; Ishikawa, Hiroshi; Xu, Juan; Kim, Jongsick; Kagemann, Larry; Folio, Lindsey S; Schuman, Joel S.

2010-01-01

Three dimensional (3D) ophthalmic imaging using optical coherence tomography (OCT) has revolutionized assessment of the eye, the retina in particular. Recent technological improvements have made the acquisition of 3D-OCT datasets feasible. However, while volumetric data can improve disease diagnosis and follow-up, novel image analysis techniques are now necessary in order to process the dense 3D-OCT dataset. Fundamental software improvements include methods for correcting subject eye motion, segmenting structures or volumes of interest, extracting relevant data post hoc and signal averaging to improve delineation of retinal layers. In addition, innovative methods for image display, such as C-mode sectioning, provide a unique viewing perspective and may improve interpretation of OCT images of pathologic structures. While all of these methods are being developed, most remain in an immature state. This review describes the current status of 3D-OCT scanning and interpretation, and discusses the need for standardization of clinical protocols as well as the potential benefits of 3D-OCT scanning that could come when software methods for fully exploiting these rich data sets are available clinically. The implications of new image analysis approaches include improved reproducibility of measurements garnered from 3D-OCT, which may then help improve disease discrimination and progression detection. In addition, 3D-OCT offers the potential for preoperative surgical planning and intraoperative surgical guidance. PMID:20542136

Image analysis tools and emerging algorithms for expression proteomics

PubMed Central

English, Jane A.; Lisacek, Frederique; Morris, Jeffrey S.; Yang, Guang-Zhong; Dunn, Michael J.

2012-01-01

Since their origins in academic endeavours in the 1970s, computational analysis tools have matured into a number of established commercial packages that underpin research in expression proteomics. In this paper we describe the image analysis pipeline for the established 2-D Gel Electrophoresis (2-DE) technique of protein separation, and by first covering signal analysis for Mass Spectrometry (MS), we also explain the current image analysis workflow for the emerging high-throughput ‘shotgun’ proteomics platform of Liquid Chromatography coupled to MS (LC/MS). The bioinformatics challenges for both methods are illustrated and compared, whilst existing commercial and academic packages and their workflows are described from both a user’s and a technical perspective. Attention is given to the importance of sound statistical treatment of the resultant quantifications in the search for differential expression. Despite wide availability of proteomics software, a number of challenges have yet to be overcome regarding algorithm accuracy, objectivity and automation, generally due to deterministic spot-centric approaches that discard information early in the pipeline, propagating errors. We review recent advances in signal and image analysis algorithms in 2-DE, MS, LC/MS and Imaging MS. Particular attention is given to wavelet techniques, automated image-based alignment and differential analysis in 2-DE, Bayesian peak mixture models and functional mixed modelling in MS, and group-wise consensus alignment methods for LC/MS. PMID:21046614

Time perspective and exercise, obesity, and smoking: moderation of associations by age.

PubMed

Guthrie, Lori C; Butler, Stephen C; Lessl, Kristen; Ochi, Onyinyechukwu; Ward, Michael M

2014-01-01

Time perspective, a psychological construct denoting subjective orientation to either present or future concerns, has been inconsistently associated with healthy behaviors in adults. We hypothesized that associations would be stronger in young adults, who are first developing independent attitudes, than in older adults. Cross-sectional survey. The study was conducted in three cities in the Mid-Atlantic region. Subjects were 790 patrons of barber and beauty shops. Measures used were the Zimbardo Time Perspective Inventory future, present-fatalistic, and present-hedonistic subscales and current smoking, days per week of recreational exercise, and height and weight, by self-report. We tested if associations between time perspective and exercise, obesity, and current smoking differed by age group (18-24 years, 25-34 years, and 35 years and older) using analysis of variance and logistic regression. Higher future time perspective scores, indicating greater focus on future events, was associated with more frequent exercise, whereas higher present-fatalistic time perspective scores, indicating more hopelessness, was associated with less frequent exercise in 18- to 24-year-olds, but not in older individuals. Lower future time perspective scores, and higher present-hedonistic time perspective scores, indicating interest in pleasure-seeking, were also associated with obesity only in 18- to 24-year-olds. Current smoking was not related to time perspective in any age group. Time perspective has age-specific associations with exercise and obesity, suggesting stages when time perspective may influence health behavior decision making.

TIME PERSPECTIVE AND EXERCISE, OBESITY AND SMOKING: MODERATION OF ASSOCIATIONS BY AGE

PubMed Central

Guthrie, LC; Butler, SC; Lessl, K; Ochi, O; Ward, MM

2014-01-01

Purpose Time perspective, a psychological construct denoting subjective orientation to either present or future concerns, has been inconsistently associated with healthy behaviors in adults. We hypothesized that associations would be stronger in young adults, who are first developing independent attitudes, than in older adults. Design Cross-sectional survey. Setting Three cities in the Mid-Atlantic region. Subjects 790 patrons of barber and beauty shops. Measures Zimbardo Time Perspective Inventory future, present-fatalistic, and present-hedonistic subscales, current smoking, days per week of recreational exercise, and height and weight, by self-report. Analysis We tested if associations between time perspective and exercise, obesity, and current smoking differed by age group (18–24 years, 25–34 years, and 35 and older) using analysis of variance and logistic regression. Results Higher future time perspective scores, indicating greater focus on future events, was associated with more frequent exercise, while higher present-fatalistic time perspective scores, indicating more hopelessness, was associated with less frequent exercise in 18 – 24 year olds, but not in older individuals. Lower future time perspective scores, and higher present-hedonistic time perspective scores, indicating interest in pleasure-seeking, were also associated with obesity only in 18 – 24 year olds. Current smoking was not related to time perspective in any age group. Conclusion Time perspective has age-specific associations with exercise and obesity, suggesting stages when time perspective may influence health behavior decision-making. PMID:24200252

The contribution of medical physics to nuclear medicine: a physician's perspective.

PubMed

Ell, Peter J

2014-12-01

This paper is the second in a series of invited perspectives by four pioneers of nuclear medicine imaging and physics. A medical physicist and a nuclear medicine clinical specialist each take a backward look and a forward look at the contributions of physics to nuclear medicine. Here is a backward look from a nuclear medicine physician's perspective.

Development of Multi-perspective Diagnostics and Analysis Algorithms with Applications to Subsonic and Supersonic Combustors

NASA Astrophysics Data System (ADS)

Wickersham, Andrew Joseph

There are two critical research needs for the study of hydrocarbon combustion in high speed flows: 1) combustion diagnostics with adequate temporal and spatial resolution, and 2) mathematical techniques that can extract key information from large datasets. The goal of this work is to address these needs, respectively, by the use of high speed and multi-perspective chemiluminescence and advanced mathematical algorithms. To obtain the measurements, this work explored the application of high speed chemiluminescence diagnostics and the use of fiber-based endoscopes (FBEs) for non-intrusive and multi-perspective chemiluminescence imaging up to 20 kHz. Non-intrusive and full-field imaging measurements provide a wealth of information for model validation and design optimization of propulsion systems. However, it is challenging to obtain such measurements due to various implementation difficulties such as optical access, thermal management, and equipment cost. This work therefore explores the application of FBEs for non-intrusive imaging to supersonic propulsion systems. The FBEs used in this work are demonstrated to overcome many of the aforementioned difficulties and provided datasets from multiple angular positions up to 20 kHz in a supersonic combustor. The combustor operated on ethylene fuel at Mach 2 with an inlet stagnation temperature and pressure of approximately 640 degrees Fahrenheit and 70 psia, respectively. The imaging measurements were obtained from eight perspectives simultaneously, providing full-field datasets under such flow conditions for the first time, allowing the possibility of inferring multi-dimensional measurements. Due to the high speed and multi-perspective nature, such new diagnostic capability generates a large volume of data and calls for analysis algorithms that can process the data and extract key physics effectively. To extract the key combustion dynamics from the measurements, three mathematical methods were investigated in this work: Fourier analysis, proper orthogonal decomposition (POD), and wavelet analysis (WA). These algorithms were first demonstrated and tested on imaging measurements obtained from one perspective in a sub-sonic combustor (up to Mach 0.2). The results show that these algorithms are effective in extracting the key physics from large datasets, including the characteristic frequencies of flow-flame interactions especially during transient processes such as lean blow off and ignition. After these relatively simple tests and demonstrations, these algorithms were applied to process the measurements obtained from multi-perspective in the supersonic combustor. compared to past analyses (which have been limited to data obtained from one perspective only), the availability of data at multiple perspective provide further insights into the flame and flow structures in high speed flows. In summary, this work shows that high speed chemiluminescence is a simple yet powerful combustion diagnostic. Especially when combined with FBEs and the analyses algorithms described in this work, such diagnostics provide full-field imaging at high repetition rate in challenging flows. Based on such measurements, a wealth of information can be obtained from proper analysis algorithms, including characteristic frequency, dominating flame modes, and even multi-dimensional flame and flow structures.

Factors Contributing to University Image: The Postgraduate Students' Points of View

ERIC Educational Resources Information Center

Aghaz, Asal; Hashemi, Amin; Atashgah, Maryam S. Sharifi

2015-01-01

Despite several studies having been conducted to examine organizational image from a business perspective, there has not been adequate research in the area of perceived image in nonprofit organizations such as universities. Thus, the purpose of this study was to examine the factors contributing to university image, from the postgraduate students'…

Generation of oculomotor images during tasks requiring visual recognition of polygons.

PubMed

Olivier, G; de Mendoza, J L

2001-06-01

This paper concerns the contribution of mentally simulated ocular exploration to generation of a visual mental image. In Exp. 1, repeated exploration of the outlines of an irregular decagon allowed an incidental learning of the shape. Analyses showed subjects memorized their ocular movements rather than the polygon. In Exp. 2, exploration of a reversible figure such as a Necker cube varied in opposite directions. Then, both perspective possibilities are presented. The perspective the subjects recognized depended on the way they explored the ambiguous figure. In both experiments, during recognition the subjects recalled a visual mental image of the polygon they compared with the different polygons proposed for recognition. To interpret the data, hypotheses concerning common processes underlying both motor intention of ocular movements and generation of a visual image are suggested.

Three dimensional perspective view of portion of western Galapagos Islands

NASA Technical Reports Server (NTRS)

1994-01-01

This is a three dimensional perspective view of Isla Isabela in the western Galapagos Islands. It was taken by the L-band radar in HH polarization from the Spaceborne Imaging Radar-C/X-Band Synthetic Aperature Radar on the 40th orbit of the Shuttle Endeavour. This view was constructed by overlaying a SIR-C radar image on a U.S. Geological Survey digital elevation map. The image is centered at about .5 degrees south latitude and 91 degrees West longitude and covers an area of 75 km by 60 km. This SIR-C/X-SAR image of Alcedo and Sierra Negra volcanoes shows the rougher lava flows as bright features, while ash deposits and smooth Pahoehoe lava flows dark. The Jet Propulsion Laboratory alternative photo number is P-43938.

The effect of the observer vantage point on perceived distortions in linear perspective images.

PubMed

Todorović, Dejan

2009-01-01

Some features of linear perspective images may look distorted. Such distortions appear in two drawings by Jan Vredeman de Vries involving perceived elliptical, instead of circular, pillars and tilted, instead of upright, columns. Distortions may be due to factors intrinsic to the images, such as violations of the so-called Perkins's laws, or factors extrinsic to them, such as observing the images from positions different from their center of projection. When the correct projection centers for the two drawings were reconstructed, it was found that they were very close to the images and, therefore, practically unattainable in normal observation. In two experiments, enlarged versions of images were used as stimuli, making the positions of the projection centers attainable for observers. When observed from the correct positions, the perceived distortions disappeared or were greatly diminished. Distortions perceived from other positions were smaller than would be predicted by geometrical analyses, possibly due to flatness cues in the images. The results are relevant for the practical purposes of creating faithful impressions of 3-D spaces using 2-D images.

Crop Row Detection in Maize Fields Inspired on the Human Visual Perception

PubMed Central

Romeo, J.; Pajares, G.; Montalvo, M.; Guerrero, J. M.; Guijarro, M.; Ribeiro, A.

2012-01-01

This paper proposes a new method, oriented to image real-time processing, for identifying crop rows in maize fields in the images. The vision system is designed to be installed onboard a mobile agricultural vehicle, that is, submitted to gyros, vibrations, and undesired movements. The images are captured under image perspective, being affected by the above undesired effects. The image processing consists of two main processes: image segmentation and crop row detection. The first one applies a threshold to separate green plants or pixels (crops and weeds) from the rest (soil, stones, and others). It is based on a fuzzy clustering process, which allows obtaining the threshold to be applied during the normal operation process. The crop row detection applies a method based on image perspective projection that searches for maximum accumulation of segmented green pixels along straight alignments. They determine the expected crop lines in the images. The method is robust enough to work under the above-mentioned undesired effects. It is favorably compared against the well-tested Hough transformation for line detection. PMID:22623899

Fast laboratory-based micro-computed tomography for pore-scale research: Illustrative experiments and perspectives on the future

NASA Astrophysics Data System (ADS)

Bultreys, Tom; Boone, Marijn A.; Boone, Matthieu N.; De Schryver, Thomas; Masschaele, Bert; Van Hoorebeke, Luc; Cnudde, Veerle

2016-09-01

Over the past decade, the wide-spread implementation of laboratory-based X-ray micro-computed tomography (micro-CT) scanners has revolutionized both the experimental and numerical research on pore-scale transport in geological materials. The availability of these scanners has opened up the possibility to image a rock's pore space in 3D almost routinely to many researchers. While challenges do persist in this field, we treat the next frontier in laboratory-based micro-CT scanning: in-situ, time-resolved imaging of dynamic processes. Extremely fast (even sub-second) micro-CT imaging has become possible at synchrotron facilities over the last few years, however, the restricted accessibility of synchrotrons limits the amount of experiments which can be performed. The much smaller X-ray flux in laboratory-based systems bounds the time resolution which can be attained at these facilities. Nevertheless, progress is being made to improve the quality of measurements performed on the sub-minute time scale. We illustrate this by presenting cutting-edge pore scale experiments visualizing two-phase flow and solute transport in real-time with a lab-based environmental micro-CT set-up. To outline the current state of this young field and its relevance to pore-scale transport research, we critically examine its current bottlenecks and their possible solutions, both on the hardware and the software level. Further developments in laboratory-based, time-resolved imaging could prove greatly beneficial to our understanding of transport behavior in geological materials and to the improvement of pore-scale modeling by providing valuable validation.

Visions of Our Planet's Atmosphere, Land & Oceans - ETheater Presentation

NASA Technical Reports Server (NTRS)

Hasler, F.

2000-01-01

The NASA/NOAA/AMS Earth Science Electronic Theater presents Earth science observations and visualizations in a historical perspective. Fly in from outer space to Florida and the KSC Visitor's Center. Go back to the early weather satellite images from the 1960s see them contrasted with the latest International global satellite weather movies including killer hurricanes & tornadic thunderstorms. See the latest spectacular images from NASA and NOAA remote sensing missions like GOES, NOAA, TRMM, SeaWiFS, Landsat7, & new Terra which will be visualized with state-of-the art tools. Shown in High Definition TV resolution (2048 x 768 pixels) are visualizations of hurricanes Lenny, Floyd, Georges, Mitch, Fran and Linda. See visualizations featured on covers of ma'gazines like Newsweek, TIME, National Geographic, Popular Science and on National & International Network TV. New Digital Earth visualization tools allow us to roam & zoom through massive global images including a Landsat tour of the US, with drill-downs into major cities using 1 m resolution spy-satellite technology from the Space Imaging IKONOS satellite. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa. See ocean vortexes and currents that bring up the nutrients to feed tiny plankton and draw the fish, giant whales and fisherman. See the how the ocean blooms in response to these currents and El Nino/La Nina climate changes. The demonstration is interactively driven by a SGI Octane Graphics Supercomputer with dual CPUS, 5 Gigabytes of RAM and Terabyte disk using two projectors across the super sized Universe Theater panoramic screen.

A Presentation of Spectracular Visualizations

NASA Technical Reports Server (NTRS)

Hasler, Fritz; Pierce, Hal; Einaudi, Franco (Technical Monitor)

2000-01-01

The NASA/NOAA/AMS Earth Science Electronic Theater presents Earth science observations and visualizations in a historical perspective. Fly in from outer space to Florida and the KSC Visitor's Center. Go back to the early weather satellite images from the 1960s see them contrasted with the latest International global satellite weather movies including killer hurricanes & tornadic thunderstorms. See the latest spectacular images from NASA and NOAA remote sensing missions like GOES, NOAA, TRMM, SeaWiFS, Landsat7, & new Terra which will be visualized with state-of-the art tools. Shown in High Definition TV resolution (2048 x 768 pixels) are visualizations of hurricanes Lenny, Floyd, Georges, Mitch, Fran and Linda. See visualizations featured on covers of magazines like Newsweek, TIME, National Geographic, Popular Science and on National & International Network TV. New Digital Earth visualization tools allow us to roam & zoom through massive global images including a Landsat tour of the US, with drill-downs into major cities using I m resolution spy-satellite technology from the Space Imaging IKONOS satellite. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa. See ocean vortexes and currents that bring up the nutrients to feed tiny plankton and draw the fish, giant whales and fisherman. See the how the ocean blooms in response to these currents and El Nino/La Nina climate changes. The demonstration is interactively driven by a SGI Octane Graphics Supercomputer with dual CPUs, 5 Gigabytes of RAM and Terabyte disk using two projectors across the super sized Universe Theater panoramic screen.

Visions of Our Planet's Atmosphere, Land and Oceans: Electronic-Theater 2000

NASA Technical Reports Server (NTRS)

Hasler, A. F.

2000-01-01

The NASA/NOAA/AMS Earth Science Electronic Theater presents Earth science observations and visualizations in a historical perspective. Fly in from outer space to the Delaware Bay and Philadelphia area. Go back to the early weather satellite images from the 1960s see them contrasted with the latest International global satellite weather movies including killer tropical cyclones & tornadic thunderstorms. See the latest spectacular images from NASA, NOAA & UMETSAT remote sensing missions like GOES, Meteosat, NOAA, TRMM, SeaWiFS, Landsat7, & new Terra which will be visualized with state-of-the art tools. Shown in High Definition TV resolution (2048 x 768 pixels) are visualizations of hurricanes Lenny, Floyd, Georges, Mitch, Fran and Linda. see visualizations featured on covers of magazines like Newsweek, TIME, National Geographic, Popular Science and on National & International Network TV. New Digital Earth visualization tools allow us to roam & zoom through massive global images including Landsat tours of the US, and Africa with drill downs of major global cities using 1 m resolution commercialized spy-satellite technology from the Space Imaging IKONOS satellite. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa. see ocean vortexes and currents that bring up the nutrients to feed tiny plankton and draw the fish, giant whales and fisherman. See the how the ocean blooms in response to these currents and El Nino/La Nina climate changes. The demonstration is interactively driven by a SGI Octane Graphics Supercomputer with dual CPUs, 5 Gigabytes of RAM and Terabyte disk using two projectors across a super sized panoramic screen.

NASA/NOAA/AMS Earth Science Electronic Theatre

NASA Technical Reports Server (NTRS)

Hasler, Fritz; Pierce, Hal; Einaudi, Franco (Technical Monitor)

2001-01-01

The NASA/NOAA/AMS Earth Science Electronic Theater presents Earth science observations and visualizations in a historical perspective. Fly in from outer space to Florida and the KSC Visitor's Center. Go back to the early weather satellite images from the 1960s see them contrasted with the latest International global satellite weather movies including killer hurricanes & tornadic thunderstorms. See the latest spectacular images from NASA and NOAA remote sensing missions like GOES, NOAA, TRMM, SeaWiFS, Landsat 7, & new Terra which will be visualized with state-of-the art tools. Shown in High Definition TV resolution (2048 x 768 pixels) are visualizations of hurricanes Lenny, Floyd, Georges, Mitch, Fran and Linda. See visualizations featured on covers of magazines like Newsweek, TIME, National Geographic, Popular Science and on National & International Network TV. New Digital Earth visualization tools allow us to roam & zoom through massive global images including a Landsat tour of the US, with drill-downs into major cities using 1 m resolution spy-satellite technology from the Space Imaging IKONOS satellite, Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa. See ocean vortexes and currents that bring up the nutrients to feed tiny plankton and draw the fish, giant whales and fisherman. See the how the ocean blooms in response to these currents and El Nino/La Nina climate changes. The demonstration is interactively driven by a SGI Octane Graphics Supercomputer with dual CPUs, 5 Gigabytes of RAM and Terabyte disk using two projectors across the super sized Universe Theater panoramic screen.

A Presentation of Spectacular Visualizations. Visions of Our Planet's Atmosphere, Land and Oceans: ETheater Presentation

NASA Technical Reports Server (NTRS)

Hasler, Fritz; Pierce, Hal; Einaudi, Franco (Technical Monitor)

2000-01-01

The NASA/NOAA/AMS Earth Science Electronic Theater presents Earth science observations and visualizations in a historical perspective. Fly in from outer space to Florida and the KSC Visitor's Center. Go back to the early weather satellite images from the 1960s see them contrasted with the latest International global satellite weather movies including killer hurricanes & tornadic thunderstorms. See the latest spectacular images from NASA and NOAA remote sensing missions like GOES, NOAA, TRMM, SeaWiFS, Landsat7, & new Terra which will be visualized with state-of-the art tools. Shown in High Definition TV resolution (2048 x 768 pixels) are visualizations of hurricanes Lenny, Floyd, Georges, Mitch, Fran and Linda. See visualizations featured on covers of magazines like Newsweek, TIME, National Geographic, Popular Science and on National & International Network TV. New Digital Earth visualization tools allow us to roam & zoom through massive global images including a Landsat tour of the US, with drill-downs into major cities using 1 m resolution spy-satellite technology from the Space Imaging IKONOS satellite. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa. See ocean vortices and currents that bring up the nutrients to feed tiny plankton and draw the fish, giant whales and fisherman. See how the ocean blooms in response to these currents and El Nino/La Nina climate changes. The demonstration is interactively driven by a SGI Octane Graphics Supercomputer with dual CPUs, 5 Gigabytes of RAM and Terabyte disk using two projectors across the super sized Universe Theater panoramic screen.

In Pursuit of Image: How We Think about Photographs We Seek

ERIC Educational Resources Information Center

Oyarce, Sara

2012-01-01

The user perspective of image search remains poorly understood. The purpose of this study is to identify and investigate the key issues relevant to a user's interaction with images and the user's approach to image search. A deeper understanding of these issues will serve to inform the design of image retrieval systems and in turn better…

Interior Design Trends in Libraries.

ERIC Educational Resources Information Center

Sager, Don, Ed.

2000-01-01

Four contributing authors discuss perspectives on current trends in library interior design. Articles include: "Trends in Library Furnishings: A Manufacturer's Perspective" (Andrea Johnson); "Libraries, Architecture, and Light: The Architect's Perspective" (Rick McCarthy); "The Library Administrator's Perspective" (Chadwick Raymond); and "The…

Cancer Imaging at the Crossroads of Precision Medicine: Perspective From an Academic Imaging Department in a Comprehensive Cancer Center.

PubMed

Van den Abbeele, Annick D; Krajewski, Katherine M; Tirumani, Sree Harsha; Fennessy, Fiona M; DiPiro, Pamela J; Nguyen, Quang-Dé; Harris, Gordon J; Jacene, Heather A; Lefever, Greg; Ramaiya, Nikhil H

2016-04-01

The authors propose one possible vision for the transformative role that cancer imaging in an academic setting can play in the current era of personalized and precision medicine by sharing a conceptual model that is based on experience and lessons learned designing a multidisciplinary, integrated clinical and research practice at their institution. The authors' practice and focus are disease-centric rather than imaging-centric. A "wall-less" infrastructure has been developed, with bidirectional integration of preclinical and clinical cancer imaging research platforms, enabling rapid translation of novel cancer drugs from discovery to clinical trial evaluation. The talents and expertise of medical professionals, scientists, and staff members have been coordinated in a horizontal and vertical fashion through the creation of Cancer Imaging Consultation Services and the "Adopt-a-Radiologist" campaign. Subspecialized imaging consultation services at the hub of an outpatient cancer center facilitate patient decision support and management at the point of care. The Adopt-a-Radiologist campaign has led to the creation of a novel generation of imaging clinician-scientists, fostered new collaborations, increased clinical and academic productivity, and improved employee satisfaction. Translational cancer research is supported, with a focus on early in vivo testing of novel cancer drugs, co-clinical trials, and longitudinal tumor imaging metrics through the imaging research core laboratory. Finally, a dedicated cancer imaging fellowship has been developed, promoting the future generation of cancer imaging specialists as multidisciplinary, multitalented professionals who are trained to effectively communicate with clinical colleagues and positively influence patient care. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Nuclear Magnetic Resonance Technology for Medical Studies.

ERIC Educational Resources Information Center

Budinger, Thomas F.; Lauterbur, Paul C.

1984-01-01

Reports on the status of nuclear magnetic resonance (NMR) from theoretical and clinical perspectives, reviewing NMR theory and relaxation parameters relevant to NMR imaging. Also reviews literature related to modern imaging strategies, signal-to-noise ratio, contrast agents, in vivo spectroscopy, spectroscopic imaging, clinical applications, and…

A Striking Perspective

NASA Image and Video Library

2015-04-16

This image from NASA MESSENGER spacecraft provides a perspective view of the center portion of Carnegie Rupes, a large tectonic landform, which cuts through Duccio crater. The image shows the terrain (variations in topography) as measured by the MLA instrument and surface mapped by the MDIS instrument. The image was color-coded to highlight the variations in topography (red = high standing terrain, blue = low lying terrain). Tectonic landforms such as Carnegie Rupes form on Mercury as a response to interior planetary cooling, resulting in the overall shrinking of the planet. To make this graphic, 48 individual MDIS images were used as part of the mosaic. Instruments: Mercury Dual Imaging System (MDIS) and Mercury Laser Altimeter (MLA) Latitude: 57.1° Longitude: 304.0° E Scale: Duccio crater has a diameter of roughly 105 kilometers (65 miles) Height: Portions of Carnegie Rupes are nearly 2 kilometers (1.2 miles) in height Orientation: North is roughly to the left of the image http://photojournal.jpl.nasa.gov/catalog/PIA19422

NASA UAVSAR Images Colorado Slumgullion Landslide

NASA Image and Video Library

2012-08-15

This false-color, oblique perspective image of the Slumgullion landslide in southwestern Colorado depicting its surface motion was created by data acquired by NASA UAVSAR between two airplane flights in August 2011.

Perspective View with Landsat Overlay, Palm Springs, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

The city of Palm Springs nestles at the base of Mount San Jacinto in this computer-generated perspective viewed from the east. The many golf courses in the area show up as irregular green areas while the two prominent lines passing through the middle of the image are Interstate 10 and the adjacent railroad tracks. The San Andreas Fault passes through the middle of the sandy Indio Hills in the foreground.

This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced color Landsat 5satellite image. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR)that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise,Washington, D.C.

Size: scale varies in this perspective image Location: 33.8 deg. North lat., 116.3 deg. West lon. Orientation: looking west Image Data: Landsat Bands 3, 2, 1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet), Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Full resolution hologram-like autostereoscopic display

NASA Technical Reports Server (NTRS)

Eichenlaub, Jesse B.; Hutchins, Jamie

1995-01-01

Under this program, Dimension Technologies Inc. (DTI) developed a prototype display that uses a proprietary illumination technique to create autostereoscopic hologram-like full resolution images on an LCD operating at 180 fps. The resulting 3D image possesses a resolution equal to that of the LCD along with properties normally associated with holograms, including change of perspective with observer position and lack of viewing position restrictions. Furthermore, this autostereoscopic technique eliminates the need to wear special glasses to achieve the parallax effect. Under the program a prototype display was developed which demonstrates the hologram-like full resolution concept. To implement such a system, DTI explored various concept designs and enabling technologies required to support those designs. Specifically required were: a parallax illumination system with sufficient brightness and control; an LCD with rapid address and pixel response; and an interface to an image generation system for creation of computer graphics. Of the possible parallax illumination system designs, we chose a design which utilizes an array of fluorescent lamps. This system creates six sets of illumination areas to be imaged behind an LCD. This controlled illumination array is interfaced to a lenticular lens assembly which images the light segments into thin vertical light lines to achieve the parallax effect. This light line formation is the foundation of DTI's autostereoscopic technique. The David Sarnoff Research Center (Sarnoff) was subcontracted to develop an LCD that would operate with a fast scan rate and pixel response. Sarnoff chose a surface mode cell technique and produced the world's first large area pi-cell active matrix TFT LCD. The device provided adequate performance to evaluate five different perspective stereo viewing zones. A Silicon Graphics' Iris Indigo system was used for image generation which allowed for static and dynamic multiple perspective image rendering. During the development of the prototype display, we identified many critical issues associated with implementing such a technology. Testing and evaluation enabled us to prove that this illumination technique provides autostereoscopic 3D multi perspective images with a wide range of view, smooth transition, and flickerless operation given suitable enabling technologies.

SRTM Perspective View with Landsat Overlay: Bhuj, India

NASA Image and Video Library

2001-04-05

This perspective view shows the city of Bhuj, India, in the foreground gray area after an earthquake in western India on January 26, 2001. This image was generated from NASA Landsat satellite and data from Shuttle Radar Topography Mission SRTM.

Perspective View, Landsat Overlay Pasadena, California

NASA Image and Video Library

2000-02-21

This image shows a perspective view of the area around Pasadena, California, just north of Los Angeles. The cluster of hills surrounded by freeways on the left is the Verdugo Hills, which lie between the San Gabriel Valley and the San Fernando Valley.

Ultrasound guided fluorescence molecular tomography with improved quantification by an attenuation compensated born-normalization and in vivo preclinical study of cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Baoqiang; Berti, Romain; Abran, Maxime

2014-05-15

Ultrasound imaging, having the advantages of low-cost and non-invasiveness over MRI and X-ray CT, was reported by several studies as an adequate complement to fluorescence molecular tomography with the perspective of improving localization and quantification of fluorescent molecular targets in vivo. Based on the previous work, an improved dual-modality Fluorescence-Ultrasound imaging system was developed and then validated in imaging study with preclinical tumor model. Ultrasound imaging and a profilometer were used to obtain the anatomical prior information and 3D surface, separately, to precisely extract the tissue boundary on both sides of sample in order to achieve improved fluorescence reconstruction. Furthermore,more » a pattern-based fluorescence reconstruction on the detection side was incorporated to enable dimensional reduction of the dataset while keeping the useful information for reconstruction. Due to its putative role in the current imaging geometry and the chosen reconstruction technique, we developed an attenuation compensated Born-normalization method to reduce the attenuation effects and cancel off experimental factors when collecting quantitative fluorescence datasets over large area. Results of both simulation and phantom study demonstrated that fluorescent targets could be recovered accurately and quantitatively using this reconstruction mechanism. Finally, in vivo experiment confirms that the imaging system associated with the proposed image reconstruction approach was able to extract both functional and anatomical information, thereby improving quantification and localization of molecular targets.« less

Nasal juvenile angiofibroma: Current perspectives with emphasis on management.

PubMed

López, Fernando; Triantafyllou, Asterios; Snyderman, Carl H; Hunt, Jennifer L; Suárez, Carlos; Lund, Valerie J; Strojan, Primož; Saba, Nabil F; Nixon, Iain J; Devaney, Kenneth O; Alobid, Isam; Bernal-Sprekelsen, Manuel; Hanna, Ehab Y; Rinaldo, Alessandra; Ferlito, Alfio

2017-05-01

Juvenile angiofibroma is an uncommon, benign, locally aggressive vascular tumor. It is found almost exclusively in young men. Common presenting symptoms include nasal obstruction and epistaxis. More advanced tumors may present with facial swelling and visual or neurological disturbances. The evaluation of patients with juvenile angiofibroma relies on diagnostic imaging. Preoperative biopsy is not recommended. The mainstay of treatment is resection combined with preoperative embolization. Endoscopic surgery is the approach of choice in early stages, whereas, in advanced stages, open or endoscopic approaches are feasible in expert hands. Postoperative radiotherapy (RT) or stereotactic radiosurgery seem valuable in long-term control of juvenile angiofibroma, particularly those that extend to anatomically critical areas unsuitable for complete resection. Chemotherapy and hormone therapy are ineffective. The purpose of the present review was to update current aspects of knowledge related to this rare and challenging disease. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1033-1045, 2017. © 2017 Wiley Periodicals, Inc.

Current Perspectives in Distributive Education.

ERIC Educational Resources Information Center

Klaurens, Mary K., Ed.; Trapnell, Gail, Ed.

The volume on current perspectives in distributive education contains 29 individually authored articles organized into three sections. The first section on program conceptualization deals with the following subjects: the evolution of distributive education, program planning, advisory committees, placement services, postsecondary distributive…

Imaging and imagining chronic obstructive pulmonary disease (COPD): Uruguayans draw their lungs.

PubMed

Wainwright, Megan

2017-09-11

This anthropological study investigated what people imagined chronic obstructive pulmonary disease to look like in their lungs, what may be influencing these images and how this imagery shapes embodiment. Employing graphic elicitation, in one of multiple ethnographic interviews, participants were asked to draw their lungs: "If we could look inside your chest now, what would we see?" Lung drawings and accompanying narratives and fieldnotes from 14 participants were analyzed for themes and patterns. The theme of "imaging/imagining" emerged and three distinct patterns within this theme were identified: the microscope perspective, the X-ray perspective and the reduced pulmonary capacity perspective. These patterns demonstrate how embodiment can be shaped by an integration and reinterpretation of the medical images that form part of everyday clinic visits and pulmonary rehabilitation. Medical technology and images impact patients' embodiment. Understanding this is important for rehabilitation practitioners who work in a challenging space created by potentially conflicting medical narratives: on the one hand, chronic obstructive pulmonary disease is incurable permanent damage, and on the other, improvement is possible through rehabilitation. Drawing could be integrated into pulmonary rehabilitation and may help identify perceptions of the body that could hinder the rehabilitation process. Implications for rehabilitation Drawings, when combined with interviews, can lead to a deeper and more complex understanding of patients' perspectives and embodiment. Rehabilitation practitioners should be concerned with how patients embody the medical technology and imagery they are exposed to as part of the educational component of pulmonary rehabilitation and healthcare generally. Asking patients to visualize their illness through drawing may help pulmonary rehabilitation practitioners identify perceptions of the body which could hinder the patient's ability to reap the full benefit of their treatment.

Perspective distortion in craniofacial superimposition: Logarithmic decay curves mapped mathematically and by practical experiment.

PubMed

Stephan, Carl N

2015-12-01

The superimposition of a face photograph with that of a skull for identification purposes necessitates the use of comparable photographic parameters between the two image acquisition sessions, so that differences in optics and consequent recording of images does not thwart the morphological analysis. Widely divergent, but published, speculations about the thresholds at which perspective distortion becomes negligible (0.5 to >13.5 m) must be resolved and perspective distortion (PD) relationships quantified across their full range to judge tolerance levels, and the suitability of commonly employed contemporary equipment (e.g., 1 m photographic copy-stands). Herein, basic trigonometry is employed to map PD for two same sized 179 mm linear lengths - separated anteroposteriorly by 127 mm - as a function of subject-to-camera distance (SCD; 0.2-20 m). These lengths approximate basic craniofacial heights (e.g., tr-n) and widths (e.g., zy-zy), while the latter approximates facial depth (e.g., n-t). As anticipated, PD decayed in logarithmic and continuous manner with increasing SCD. At SCD of 12 m, the within-image PD was negligible (<1%). At <2.5 m SCD, it exceeded 5% and increased sharply as SCD decreased. Since life size images of skulls and faces are commonly employed for superimposition, a relative 1% perspective distortion difference is recommended as the ceiling standard for craniofacial comparison (translates into a ≤2 mm difference in physiognomical face height). Since superimposition depends on relative comparisons of a photographic pair (not one photograph), there is practically no scenario in superimposition casework where SCDs should be ignored and no single distance at which PD should be considered negligible (even if one image holds >12 m SCD). Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy.

PubMed

Wolters, Martijn; Mohades, Seyede G; Hackeng, Tilman M; Post, Mark J; Kooi, Marianne E; Backes, Walter H

2013-05-01

The number of applications of fluorine 19 (19F) magnetic resonance (MR) imaging and spectroscopy in biomedical and clinical research is steadily growing. The 100% natural abundance of fluorine and its relatively high sensitivity for MR (83% to that of protons) make it an interesting nucleus for a wide range of MR applications. Fluorinated contrast media have a number of advantages over the conventionally used gadolinium-based or iron-based contrast agents. The absence of an endogenous fluorine background intensity in the human body facilitates reliable quantification of fluorinated contrast medium or drugs. Anatomy can be visualized separately with proton MR imaging, creating the application of hybrid hydrogen 1 (1H)/19F MR imaging. The availability of 2 channels (ie, the 1H and 19F channels) enables dual-targeted molecular imaging. Recently, novel developments have emerged on fluorine-based contrast media in preclinical studies and imaging techniques. The developments in fluorine MR seem promising for clinical applications, with contributions in therapy monitoring, assessment of lung function, angiography, and molecular imaging. This review outlines the translation from recent advances in preclinical MR imaging and spectroscopy to future perspectives of clinical hybrid 1H/19/F MR imaging applications.

EFL Oral Communication Teaching Practices: A Close Look at University Teachers and A2 Students' Perspectives in Thailand and a Critical Eye from Serbia

ERIC Educational Resources Information Center

Bruner, David Allen; Sinwongsuwat, Kemtong; Radic-Bojanic, Biljana

2015-01-01

This paper aimed to reexamine current EFL oral communication teaching practices from the perspectives of teachers and A2 students at two universities, namely Prince of Songkla University (PSU), Thailand and University of Novi Sad (UNS), Serbia. The main objectives were: (1) to analyze current practices from the perspectives of teachers and…

Commercial perspective in THz spectroscopy, sensing and imaging (Conference Presentation)

NASA Astrophysics Data System (ADS)

Bouyé, Clémentine; Taoudi, Sarah; Cochard, Jacques; d'Humières, Benoît

2017-02-01

For their ability to be transmitted by materials opaque in the visible and IR ranges (clothes, plastic, …), for being non-ionizing, for providing sub-mm resolution imaging, for the specific signatures of numerous materials, Terahertz waves - ranging from 200 GHz to 10 THz - have been raising the interest of industrials for about fifteen years. This study focuses on the penetration of THz technologies into the industrial applications driving the THz market growth at short and long term: Non Destructive testing (NDT), Defense and Security, Biomedical. For 15 years, Terahertz technologies have been continuously tested on a wide variety of applications. Thanks to these ongoing feasibility studies, manufacturers and end-users gained a deeper knowledge about the abilities and the limitations of the different Terahertz systems (Time-Domain spectroscopy, Frequency-Domain spectroscopy, Time-Domain reflectometry, etc). The demand from end-users is more qualified and is segmented as follows: 1. Detection of objects and defects on large areas 2. Thickness measurement on large areas 3. Chemical and Structural characterization of small objects and defects on small areas (2D) or volumes (3D) Each of these 3 functions leads to a specific family of THz systems with distinct requirements in terms of performance and cost: 1. Detection: cheap and compact imaging systems. 2. Thickness measurement: cost-effective and high speed systems. 3. Characterization: high resolution, high reliability and real-time sensing systems. This article will present the existing and incoming THz systems and components addressing each function. Terahertz technologies are currently finding their place on the market, outside research and scientific applications. The objective of this article is to identify the industrial applications where THz techniques will be adopted and to provide market growth perspectives.

Earth Observations taken by the Expedition 22 Crew

NASA Image and Video Library

2010-01-13

ISS022-E-024940 (13 Jan. 2010) --- Man-made archipelagos near Dubai, United Arab Emirates are featured in this image photographed by an Expedition 22 crew member on the International Space Station. The municipality of Dubai is the largest city of the Persian Gulf emirate of the same name, and has built a global reputation for large-scale developments and architectural works. Among the most visible of these developments ? particularly from the perspective of astronauts onboard the ISS ? are three man-made archipelagos. The two Palm Islands (Palm Jumeirah and Palm Jebel Ali) appear as stylized palm trees when viewed from above. The World Islands evoke a rough map of the world from an air- or space-borne perspective. Palm Jumeirah and the World Islands are highlighted in this view. Palm Jumeirah (lower left) was begun in 2001 and required more than 50 million cubic meters of dredged sand to raise the islands above the Persian Gulf sea level. Construction of the Palm Jumeirah islands was completed in 2006; they are now being developed for residential and commercial housing and infrastructure. Creation of the 300 World Islands (upper right) was begun in 2003 and completed in 2008, using 320 million cubic meters of sand and 37 million tons of rock for the surrounding 27 kilometer-long protective breakwater. Also visible at the lower edge of the image is another notable built structure ? the Burj Tower (white rectangle at lower right and inset image). The Burj Tower ? or Burj Khalifa ? stands 800 meters high, and is currently the world?s tallest structure. The photograph captures enough detail to make out the tapering outline of the building as well as its dark needle-like shadow pointing towards the northeast.

Virtual Images: Going through the Looking Glass

ERIC Educational Resources Information Center

Mota, Ana Rita; Lopes dos Santos, João

2017-01-01

Virtual images are often introduced through a "geometric" perspective, with little conceptual or qualitative illustrations, hindering a deeper understanding of this physical concept. In this paper, we present two rather simple observations that force a critical reflection on the optical nature of a virtual image. This approach is…

The Life Cycle of Images: Revisiting the Ethical Treatment of the Art Therapy Image

ERIC Educational Resources Information Center

Hinz, Lisa D.

2013-01-01

Using the metaphor of the human life cycle, the author of this viewpoint suggests that consideration of the birth, life, and death of images made in art therapy may promote a new perspective on their ethical treatment. A developmental view of images encourages art therapists to see art images as living entities that undergo a natural life cycle.…

The Current Ecosystem of Learning Management Systems in Higher Education: Student, Faculty, and IT Perspectives

ERIC Educational Resources Information Center

Dahlstrom, Eden; Brooks, D. Christopher; Bichsel, Jacqueline

2014-01-01

This study explores faculty and student perspectives on learning management systems (LMSs) in the context of current institutional investments. In 2013, nearly 800 institutions participated in the EDUCAUSE Core Data Service (CDS) survey, sharing their current information technology practices and metrics across all IT service domains. In 2014, more…

MO-E-BRD-02: Accelerated Partial Breast Irradiation in Brachytherapy: Is Shorter Better?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Todor, D.

2015-06-15

Is Non-invasive Image-Guided Breast Brachytherapy Good? – Jess Hiatt, MS Non-invasive Image-Guided Breast Brachytherapy (NIBB) is an emerging therapy for breast boost treatments as well as Accelerated Partial Breast Irradiation (APBI) using HDR surface breast brachytherapy. NIBB allows for smaller treatment volumes while maintaining optimal target coverage. Considering the real-time image-guidance and immobilization provided by the NIBB modality, minimal margins around the target tissue are necessary. Accelerated Partial Breast Irradiation in brachytherapy: is shorter better? - Dorin Todor, PhD VCU A review of balloon and strut devices will be provided together with the origins of APBI: the interstitial multi-catheter implant.more » A dosimetric and radiobiological perspective will help point out the evolution in breast brachytherapy, both in terms of devices and the protocols/clinical trials under which these devices are used. Improvements in imaging, delivery modalities and convenience are among the factors driving the ultrashort fractionation schedules but our understanding of both local control and toxicities associated with various treatments is lagging. A comparison between various schedules, from a radiobiological perspective, will be given together with a critical analysis of the issues. to review and understand the evolution and development of APBI using brachytherapy methods to understand the basis and limitations of radio-biological ‘equivalence’ between fractionation schedules to review commonly used and proposed fractionation schedules Intra-operative breast brachytherapy: Is one stop shopping best?- Bruce Libby, PhD. University of Virginia A review of intraoperative breast brachytherapy will be presented, including the Targit-A and other trials that have used electronic brachytherapy. More modern approaches, in which the lumpectomy procedure is integrated into an APBI workflow, will also be discussed. Learning Objectives: To review past and current clinical trials for IORT To discuss lumpectomy-scan-plan-treat workflow for IORT.« less

Post-operative imaging in liver transplantation: State-of-the-art and future perspectives

PubMed Central

Girometti, Rossano; Como, Giuseppe; Bazzocchi, Massimo; Zuiani, Chiara

2014-01-01

Orthotopic liver transplantation (OLT) represents a major treatment for end-stage chronic liver disease, as well as selected cases of hepatocellular carcinoma and acute liver failure. The ever-increasing development of imaging modalities significantly contributed, over the last decades, to the management of recipients both in the pre-operative and post-operative period, thus impacting on graft and patients survival. When properly used, imaging modalities such as ultrasound, multidetector computed tomography, magnetic resonance imaging (MRI) and procedures of direct cholangiography are capable to provide rapid and reliable recognition and treatment of vascular and biliary complications occurring after OLT. Less defined is the role for imaging in assessing primary graft dysfunction (including rejection) or chronic allograft disease after OLT, e.g., hepatitis C virus (HCV) recurrence. This paper: (1) describes specific characteristic of the above imaging modalities and the rationale for their use in clinical practice; (2) illustrates main imaging findings related to post-OLT complications in adult patients; and (3) reviews future perspectives emerging in the surveillance of recipients with HCV recurrence, with special emphasis on MRI. PMID:24876739

Hard and soft nanoparticles for image-guided surgery in nanomedicine

NASA Astrophysics Data System (ADS)

Locatelli, Erica; Monaco, Ilaria; Comes Franchini, Mauro

2015-08-01

The use of hard and/or soft nanoparticles for therapy, collectively called nanomedicine, has great potential in the battle against cancer. Major research efforts are underway in this area leading to development of new drug delivery approaches and imaging techniques. Despite this progress, the vast majority of patients who are affected by cancer today sadly still need surgical intervention, especially in the case of solid tumors. An important perspective for researchers is therefore to provide even more powerful tools to the surgeon for pre- and post-operative approaches. In this context, image-guided surgery, in combination with nanotechnology, opens a new strategy to win this battle. In this perspective, we will analyze and discuss the recent progress with nanoparticles of both metallic and biomaterial composition, and their use to develop powerful systems to be applied in image-guided surgery.

PERSPECTIVE VIEW OF THE C. 1930 GREYHOUND BUS GARAGE (CURRENT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PERSPECTIVE VIEW OF THE C. 1930 GREYHOUND BUS GARAGE (CURRENT USE: RESTAURANT), LOCATED AT 100 NW JACKSON AVENUE, VIEW LOOKING NORTHWEST. - Corvallis Downtown Historic District, Bounded by First & Sixth Streets, Van Buren & Western Avenues, Corvallis, Benton County, OR

Liver CT image processing: a short introduction of the technical elements.

PubMed

Masutani, Y; Uozumi, K; Akahane, Masaaki; Ohtomo, Kuni

2006-05-01

In this paper, we describe the technical aspects of image analysis for liver diagnosis and treatment, including the state-of-the-art of liver image analysis and its applications. After discussion on modalities for liver image analysis, various technical elements for liver image analysis such as registration, segmentation, modeling, and computer-assisted detection are covered with examples performed with clinical data sets. Perspective in the imaging technologies is also reviewed and discussed.

Light-Field Imaging Toolkit

NASA Astrophysics Data System (ADS)

Bolan, Jeffrey; Hall, Elise; Clifford, Chris; Thurow, Brian

The Light-Field Imaging Toolkit (LFIT) is a collection of MATLAB functions designed to facilitate the rapid processing of raw light field images captured by a plenoptic camera. An included graphical user interface streamlines the necessary post-processing steps associated with plenoptic images. The generation of perspective shifted views and computationally refocused images is supported, in both single image and animated formats. LFIT performs necessary calibration, interpolation, and structuring steps to enable future applications of this technology.

To appreciate variation between scientists: A perspective for seeing science's vitality

NASA Astrophysics Data System (ADS)

Wong, E. David

2002-05-01

At the heart of theoretical and practical ideas about science education is an image of scientific work. This image draws attention to particular features of scientific work, which then guides scholarship and pedagogy in science education. In the field of science education, much discussion in this vein focuses on the question, What is the nature of science? Most images of science found in education, psychology, and philosophy emerge from conceptual and methodological perspectives that emphasize norms, conventions, and broad trends. Some groups are motivated to distinguish science from other activities while some groups work in the opposite direction and blur the lines between science and others ways of knowing. Underlying both perspectives is an implicit focus on general qualities common to groups or subgroups (e.g. believing that ideas are subject to change, explanations demand evidence, science is a complex social activities, etc.). I propose that the vital qualities of science are best illuminated by just the opposite process: by appreciating the uncommon, rather than common, features. By attending to individual variation, we are more likely to understand what makes science a creative, motivating, and deeply personal enterprise. In addition, appreciating these variations reveals judgment, creativity, adaptation - the hallmark of scientific work. Implications of this perspective for science education are discussed.

Seeing Is Believing: Using Imagery to Enhance Your Coaching

ERIC Educational Resources Information Center

Finch, Laura M.

2011-01-01

Imagery is a powerful sport psychology tool easily accessible to coaches. These reminders can help coaches improve their athletes' images and performance: (1) Create vivid and controllable images; (2) Use polysensory images and instructional cues, delivered, ideally, in real time; (3) Use internal and external perspectives; (4) Use imagery during…

Images, Anxieties, and Attitudes toward Mathematics

ERIC Educational Resources Information Center

Belbase, Shashidhar

2013-01-01

The purpose of this paper is to discuss and analyze images, anxieties, and attitudes towards mathematics in order to foster meaningful teaching and learning of mathematics. Images of mathematics seem to be profoundly shaped by epistemological, philosophical, and pedagogical perspectives of one who views mathematics either as priori or a…

Format and basic geometry of a perspective display of air traffic for the cockpit

NASA Technical Reports Server (NTRS)

Mcgreevy, Michael Wallace; Ellis, Stephen R.

1991-01-01

The design and implementation of a perspective display of air traffic for the cockpit is discussed. Parameters of the perspective are variable and interactive so that the appearance of the projected image can be widely varied. This approach makes allowances for exploration of perspective parameters and their interactions. The display was initially used to study the cases of horizontal maneuver biases found in experiments involving a plan view air traffic display format. Experiments to determine the effect of perspective geometry on spatial judgements have evolved from the display program. Several scaling techniques and other adjustments to the perspective are used to tailor the geometry for effective presentation of 3-D traffic situations.

Current Perspectives in Imaging Modalities for the Assessment of Unruptured Intracranial Aneurysms: A Comparative Analysis and Review.

PubMed

Turan, Nefize; Heider, Robert A; Roy, Anil K; Miller, Brandon A; Mullins, Mark E; Barrow, Daniel L; Grossberg, Jonathan; Pradilla, Gustavo

2018-05-01

Intracranial aneurysms (IAs) are pathologic dilatations of cerebral arteries. This systematic review summarizes and compares imaging techniques for assessing unruptured IAs (UIAs). This review also addresses their uses in different scopes of practice. Pathophysiologic mechanisms are reviewed to better understand the clinical usefulness of each imaging modality. A literature review was performed using PubMed with these search terms: "intracranial aneurysm," "cerebral aneurysm," "magnetic resonance angiography (MRA)," computed tomography angiography (CTA)," "catheter angiography," "digital subtraction angiography," "molecular imaging," "ferumoxytol," and "myeloperoxidase". Only studies in English were cited. Since the development and improvement of noninvasive diagnostic imaging (computed tomography angiography and magnetic resonance angiography), many prospective studies and meta-analyses have compared these tests with gold standard digital subtraction angiography (DSA). Although computed tomography angiography and magnetic resonance angiography have lower detection rates for UIAs, they are vital in the treatment and follow-up of UIAs. The reduction in ionizing radiation and lack of endovascular instrumentation with these modalities provide benefits compared with DSA. Novel molecular imaging techniques to detect inflammation within the aneurysmal wall with the goal of stratifying risk based on level of inflammation are under investigation. DSA remains the gold standard for preoperative planning and follow-up for patients with IA. Newer imaging modalities such as ferumoxytol-enhanced magnetic resonance imaging are emerging techniques that provide critical in vivo information about the inflammatory milieu within aneurysm walls. With further study, these techniques may provide aneurysm rupture risk and prediction models for individualized patient care. Copyright © 2018 Elsevier Inc. All rights reserved.

Go With the Flow, on Jupiter and Snow. Coherence from Model-Free Video Data Without Trajectories

NASA Astrophysics Data System (ADS)

AlMomani, Abd AlRahman R.; Bollt, Erik

2018-06-01

Viewing a data set such as the clouds of Jupiter, coherence is readily apparent to human observers, especially the Great Red Spot, but also other great storms and persistent structures. There are now many different definitions and perspectives mathematically describing coherent structures, but we will take an image processing perspective here. We describe an image processing perspective inference of coherent sets from a fluidic system directly from image data, without attempting to first model underlying flow fields, related to a concept in image processing called motion tracking. In contrast to standard spectral methods for image processing which are generally related to a symmetric affinity matrix, leading to standard spectral graph theory, we need a not symmetric affinity which arises naturally from the underlying arrow of time. We develop an anisotropic, directed diffusion operator corresponding to flow on a directed graph, from a directed affinity matrix developed with coherence in mind, and corresponding spectral graph theory from the graph Laplacian. Our methodology is not offered as more accurate than other traditional methods of finding coherent sets, but rather our approach works with alternative kinds of data sets, in the absence of vector field. Our examples will include partitioning the weather and cloud structures of Jupiter, and a local to Potsdam, NY, lake effect snow event on Earth, as well as the benchmark test double-gyre system.

The Great Red Spot Plunge (animation)

NASA Image and Video Library

2017-12-11

This frame from an animation takes the viewer on a simulated flight into, and then out of, Jupiter's upper atmosphere at the location of the Great Red Spot. The perspective begins about 2,000 miles (3,000 kilometers) above the cloud tops of the planet's southern hemisphere. The bar at far left indicates altitude during the quick descent; a second gauge next to that depicts the dramatic increase in temperature that occurs as the perspective dives deeper down. The clouds turn crimson as the perspective passes through the Great Red Spot. Finally, the view ascends out of the spot. This video was created by combining an image from the JunoCam imager on NASA's Juno spacecraft with a computer-generated animation. The animation is available at https://photojournal.jpl.nasa.gov/catalog/PIA22176

Substance Abuse and Counseling: An Epilogue.

ERIC Educational Resources Information Center

Sales, Amos

This chapter discusses current issues and future perspectives in relation to substance abuse counseling. Current issues include: abstinence versus controlled use; coercive versus voluntary treatment; and career development and counseling with clients with substance abuse problems. Future perspectives include: the impact of managed care; the…

Seeing meaning in action: a bidirectional link between visual perspective and action identification level.

PubMed

Libby, Lisa K; Shaeffer, Eric M; Eibach, Richard P

2009-11-01

Actions do not have inherent meaning but rather can be interpreted in many ways. The interpretation a person adopts has important effects on a range of higher order cognitive processes. One dimension on which interpretations can vary is the extent to which actions are identified abstractly--in relation to broader goals, personal characteristics, or consequences--versus concretely, in terms of component processes. The present research investigated how visual perspective (own 1st-person vs. observer's 3rd-person) in action imagery is related to action identification level. A series of experiments measured and manipulated visual perspective in mental and photographic images to test the connection with action identification level. Results revealed a bidirectional causal relationship linking 3rd-person images and abstract action identifications. These findings highlight the functional role of visual imagery and have implications for understanding how perspective is involved in action perception at the social, cognitive, and neural levels. Copyright 2009 APA

Helicopter Rotor Noise Prediction: Background, Current Status, and Future Direction

NASA Technical Reports Server (NTRS)

Brentner, Kenneth S.

1997-01-01

Helicopter noise prediction is increasingly important. The purpose of this viewgraph presentation is to: 1) Put into perspective the recent progress; 2) Outline current prediction capabilities; 3) Forecast direction of future prediction research; 4) Identify rotorcraft noise prediction needs. The presentation includes an historical perspective, a description of governing equations, and the current status of source noise prediction.

Perspectives on the Current Status of and Emerging Policy Issues for Private, Historically Black Colleges. AGB White Paper No. 1.

ERIC Educational Resources Information Center

Kirschner, Alan H.

1991-01-01

This paper puts in historical perspective and reviews current policy issues unique to private, historically black college. Their historical traditions and mission of service, the paper notes black private colleges currently enroll about 17 percent of blacks in higher education and award more than one-third of baccalaureate degrees earned by…

A Fourier dimensionality reduction model for big data interferometric imaging

NASA Astrophysics Data System (ADS)

Vijay Kartik, S.; Carrillo, Rafael E.; Thiran, Jean-Philippe; Wiaux, Yves

2017-06-01

Data dimensionality reduction in radio interferometry can provide savings of computational resources for image reconstruction through reduced memory footprints and lighter computations per iteration, which is important for the scalability of imaging methods to the big data setting of the next-generation telescopes. This article sheds new light on dimensionality reduction from the perspective of the compressed sensing theory and studies its interplay with imaging algorithms designed in the context of convex optimization. We propose a post-gridding linear data embedding to the space spanned by the left singular vectors of the measurement operator, providing a dimensionality reduction below image size. This embedding preserves the null space of the measurement operator and hence its sampling properties are also preserved in light of the compressed sensing theory. We show that this can be approximated by first computing the dirty image and then applying a weighted subsampled discrete Fourier transform to obtain the final reduced data vector. This Fourier dimensionality reduction model ensures a fast implementation of the full measurement operator, essential for any iterative image reconstruction method. The proposed reduction also preserves the independent and identically distributed Gaussian properties of the original measurement noise. For convex optimization-based imaging algorithms, this is key to justify the use of the standard ℓ2-norm as the data fidelity term. Our simulations confirm that this dimensionality reduction approach can be leveraged by convex optimization algorithms with no loss in imaging quality relative to reconstructing the image from the complete visibility data set. Reconstruction results in simulation settings with no direction dependent effects or calibration errors show promising performance of the proposed dimensionality reduction. Further tests on real data are planned as an extension of the current work. matlab code implementing the proposed reduction method is available on GitHub.

Space Radar Image of Saline Valley, California

NASA Image and Video Library

1999-04-15

This is a three-dimensional perspective view of Saline Valley, about 30 km 19 miles east of the town of Independence, California created by combining two spaceborne radar images using a technique known as interferometry.

Perspective View with Landsat Overlay, Costa Rica

NASA Technical Reports Server (NTRS)

2002-01-01

This perspective view shows the Caribbean coastal plain of Costa Rica, with the Cordillera Central rising in the background and the Pacific Ocean in the distance. The prominent river in the center of the image is the Rio Sucio, which merges with the Rio Sarapiqui at the bottom of the image and eventually joins with Rio San Juan on the Nicaragua border.

Like much of Central America, Costa Rica is generally cloud covered so very little satellite imagery is available. The ability of the Shuttle Radar Topography Mission (SRTM) instrument to penetrate clouds and make three-dimensional measurements will allow generation of the first complete high-resolution topographic map of the entire region. These data were used to generate the image.

This three-dimensional perspective view was generated using elevation data from SRTM and an enhanced false-color Landsat 7 satellite image. Colors are from Landsat bands 5, 4, and 2 as red, green and blue, respectively. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter resolution of most Landsat images and will substantially help in analyses of the large and growing Landsat image archive. The Landsat 7 Thematic Mapper image used here was provided to the SRTM by the United States Geological Survey, Earth Resources Observation Systems (EROS) Data Center, Sioux Falls, S.D.

Elevation data used in this image was acquired by the SRTM aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

Size: scale varies in this perspective image Location: 10.4 degrees North latitude, 84.0 degrees West longitude Orientation: looking Southwest Image Data: Landsat Bands 5, 4, 3 as red, green, blue respectively Original Data Resolution: SRTM 30 meters (99 feet) Date Acquired: February 2000 (SRTM)

See Your State From Space!

USGS Publications Warehouse

,

2008-01-01

Each of the 50 States in the United States is beautiful in its own way. That beauty can be seen from a unique perspective using satellite images taken from high above the Earth. These State images were created from multiple satellite images stitched together into one seamless image for each State. Names of major cities, administrative boundaries, and State flags have been added.

Three dimensional perspective view of false-color image of eastern Hawaii

NASA Image and Video Library

1994-04-18

This is a three dimensional perspective view of false-color image of the eastern part of the Big Island of Hawaii. It was produced using all three radar frequencies C-Band and L-Band. This view was constructed by overlaying a SIR-C radar image on a U.S. Geological Survey digital elevation map. The image was acquired on April 12, 1994 during the 52nd orbit of the Shuttle Endeavour by the Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR). The area shown is approximately 34 by 57 kilomters with the top of the image pointing toward north-west. The image is centered at about 155.25 degrees west longitude and 19.5 degrees north latitude. Visible in the center of the image in blue are the summit crater (Kilauea Caidera) which contains the smaller Halemaumau Crater, and the line of collapsed craters below them that form the Chain of Craters Road. The rain forest appears bright in the image while green areas correspond to lower vegetation. The lava flows have different colors depending on their types and are easily recognizable due to their shapes. The flows at the top of the image originated from the Muana Loa volcano. The Jet Propulsion Laboratory alternative photo number is P-43932.

The Impact of Mindfulness and Perspective-Taking on Implicit Associations Toward the Elderly: a Relational Frame Theory Account

PubMed Central

McEnteggart, Ciara; Barnes-Holmes, Yvonne; Lowe, Rob; Evans, Nicky; Vilardaga, Roger

2017-01-01

Perspective-taking interventions have been shown to improve attitudes toward social outgroups. In contrast, similar interventions have produced opposite effects (i.e., enhanced negativity) in the context of attitudes toward elderly groups. The current study investigated whether a brief perspective-taking intervention enhanced with mindfulness would be associated with less negativity than perspective-taking alone. One hundred five participants were randomly assigned to 1 of 4 conditions which comprised of an active or control perspective-taking component and an active or control mindfulness component. Participants were then administered an Implicit Associated Test to assess implicit biases toward the elderly. Results supported previous findings in that the condition in which perspective-taking was active but mindfulness was inactive was associated with greater negative implicit bias toward the elderly; however, some of this negativity decreased in the active perspective-taking and active mindfulness condition. The current findings and other mixed effects that have emerged from perspective-taking interventions are discussed from a Relational Frame Theory perspective. PMID:29399210

Semi-supervised classification tool for DubaiSat-2 multispectral imagery

NASA Astrophysics Data System (ADS)

Al-Mansoori, Saeed

2015-10-01

This paper addresses a semi-supervised classification tool based on a pixel-based approach of the multi-spectral satellite imagery. There are not many studies demonstrating such algorithm for the multispectral images, especially when the image consists of 4 bands (Red, Green, Blue and Near Infrared) as in DubaiSat-2 satellite images. The proposed approach utilizes both unsupervised and supervised classification schemes sequentially to identify four classes in the image, namely, water bodies, vegetation, land (developed and undeveloped areas) and paved areas (i.e. roads). The unsupervised classification concept is applied to identify two classes; water bodies and vegetation, based on a well-known index that uses the distinct wavelengths of visible and near-infrared sunlight that is absorbed and reflected by the plants to identify the classes; this index parameter is called "Normalized Difference Vegetation Index (NDVI)". Afterward, the supervised classification is performed by selecting training homogenous samples for roads and land areas. Here, a precise selection of training samples plays a vital role in the classification accuracy. Post classification is finally performed to enhance the classification accuracy, where the classified image is sieved, clumped and filtered before producing final output. Overall, the supervised classification approach produced higher accuracy than the unsupervised method. This paper shows some current preliminary research results which point out the effectiveness of the proposed technique in a virtual perspective.

Optimization of illumination schemes in a head-mounted display integrated with eye tracking capabilities

NASA Astrophysics Data System (ADS)

Pansing, Craig W.; Hua, Hong; Rolland, Jannick P.

2005-08-01

Head-mounted display (HMD) technologies find a variety of applications in the field of 3D virtual and augmented environments, 3D scientific visualization, as well as wearable displays. While most of the current HMDs use head pose to approximate line of sight, we propose to investigate approaches and designs for integrating eye tracking capability into HMDs from a low-level system design perspective and to explore schemes for optimizing system performance. In this paper, we particularly propose to optimize the illumination scheme, which is a critical component in designing an eye tracking-HMD (ET-HMD) integrated system. An optimal design can improve not only eye tracking accuracy, but also robustness. Using LightTools, we present the simulation of a complete eye illumination and imaging system using an eye model along with multiple near infrared LED (IRLED) illuminators and imaging optics, showing the irradiance variation of the different eye structures. The simulation of dark pupil effects along with multiple 1st-order Purkinje images will be presented. A parametric analysis is performed to investigate the relationships between the IRLED configurations and the irradiance distribution at the eye, and a set of optimal configuration parameters is recommended. The analysis will be further refined by actual eye image acquisition and processing.

Identification, recognition and misidentification syndromes: a psychoanalytical perspective

PubMed Central

Thibierge, Stéphane; Morin, Catherine

2013-01-01

Misidentification syndromes are currently often understood as cognitive disorders of either the “sense of uniqueness” (Margariti and Kontaxakis, 2006) or the recognition of people (Ellis and Lewis, 2001). It is however, necessary to consider how a normal “sense of uniqueness” or normal person recognition are acquired by normal or neurotic subjects. It will be shown here that the normal conditions of cognition can be considered as one of the possible forms of a complex structure and not as just a setting for our sense and perception data. The consistency and the permanency of the body image in neurosis is what permits the recognition of other people and ourselves as unique beings. This consistency and permanency are related to object repression, as shown by neurological disorders of body image (somatoparaphrenia), which cause the object to come to the foreground in the patient’s words (Thibierge and Morin, 2010). In misidentification syndromes, as in other psychotic syndromes, one can also observe damage to the specular image as well as an absence of object repression. This leads us to question whether, in the psychiatric disorders related to a damaged specular image, disorders of cognition can be studied and managed using the same methods as for neurotic patients. PMID:24298262

Targeted nanoparticles for image-guided treatment of triple-negative breast cancer: clinical significance and technological advances.

PubMed

Miller-Kleinhenz, Jasmine M; Bozeman, Erica N; Yang, Lily

2015-01-01

Effective treatment of triple-negative breast cancer (TNBC) with its aggressive tumor biology, highly heterogeneous tumor cells, and poor prognosis requires an integrated therapeutic approach that addresses critical issues in cancer therapy. Multifunctional nanoparticles with the abilities of targeted drug delivery and noninvasive imaging for monitoring drug delivery and responses to therapy, such as theranostic nanoparticles, hold great promise toward the development of novel therapeutic approaches for the treatment of TNBC using a single therapeutic platform. The biological and pathological characteristics of TNBC provide insight into several potential molecular targets for current and future nanoparticle-based therapeutics. Extensive tumor stroma, highly proliferative cells, and a high rate of drug resistance are all barriers that must be appropriately addressed in order for these nanotherapeutic platforms to be effective. Utilization of the enhanced permeability and retention effect coupled with active targeting of cell surface receptors expressed by TNBC cells, and tumor-associated endothelial cells, stromal fibroblasts, and macrophages is likely to overcome such barriers to facilitate more effective drug delivery. An in-depth summary of current studies investigating targeted nanoparticles in preclinical TNBC mouse and human xenograft models is presented. This review aims to outline the current status of nanotherapeutic options for TNBC patients, identification of promising molecular targets, challenges associated with the development of targeted nanotherapeutics, the research done by our group as well as by others, and future perspectives on the nanomedicine field and ways to translate current preclinical studies into the clinic. © 2015 Wiley Periodicals, Inc.

Gravitational Lensing from a Spacetime Perspective.

PubMed

Perlick, Volker

2004-01-01

The theory of gravitational lensing is reviewed from a spacetime perspective, without quasi-Newtonian approximations. More precisely, the review covers all aspects of gravitational lensing where light propagation is described in terms of lightlike geodesics of a metric of Lorentzian signature. It includes the basic equations and the relevant techniques for calculating the position, the shape, and the brightness of images in an arbitrary general-relativistic spacetime. It also includes general theorems on the classification of caustics, on criteria for multiple imaging, and on the possible number of images. The general results are illustrated with examples of spacetimes where the lensing features can be explicitly calculated, including the Schwarzschild spacetime, the Kerr spacetime, the spacetime of a straight string, plane gravitational waves, and others.

Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials.

PubMed

van la Parra, Raquel F D; Kuerer, Henry M

2016-03-08

With improvements in chemotherapy regimens, targeted therapies, and our fundamental understanding of the relationship of tumor subtype and pathologic complete response (pCR), there has been dramatic improvement in pCR rates in the past decade, especially among triple-negative and human epidermal growth factor receptor 2-positive breast cancers. Rates of pCR in these groups of patients can be in the 60 % range and thus question the paradigm for the necessity of breast and nodal surgery in all cases, particularly when the patient will be receiving adjuvant local therapy with radiotherapy. Current practice for patients who respond well to neoadjuvant chemotherapy (NCT) is often to proceed with the same breast and axillary procedures as would have been offered women who had not received NCT, regardless of the apparent clinical response. Given these high response rates in defined subgroups among exceptional responders it is appropriate to question whether surgery is now a redundant procedure in their overall management. Further, definitive radiation without surgical resection with or without systemic therapy has been proven effective for several other malignant disease sites including some stages of esophageal, anal, laryngeal, prostate, cervical, and lung carcinoma. The main impediments for potential elimination of surgery have been the fact that prior and current standard and functional breast imaging methods are incapable of accurate prediction of residual disease and that integrating percutaneous biopsy of the breast primary and nodes following NCT may circumvent this issue. This article highlights historical attempts at omission of surgery following NCT in an earlier era, the current status of breast and nodal imaging to predict residual carcinoma, and ongoing and planned trials designed to identify appropriate patients who might be selected for clinical trials designed to test the safety of selected elimination of breast cancer surgery in percutaneous image-guided biopsy-proven exceptional responders to NCT.

Perspective View with Landsat Overlay, San Diego, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

The influence of topography on the growth of the city of San Diego is seen clearly in this computer-generated perspective viewed from the south. The Peninsular Ranges to the east of the city have channeled development of the cities of La Mesa and El Cajon, above the center. San Diego itself clusters around the bay enclosed by Point Loma and Coronado Island. In the mountains to the right, Lower Otay Lake and Sweetwater Reservoir are the dark patches.

This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced color Landsat 5satellite image. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR)that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

Size: scale varies in this perspective image Location: 32.6 deg. North lat., 117.1 deg. West lon. Orientation: looking north Image Data: Landsat Bands 3, 2, 1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet), Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Administrator Perspectives of Post-Secondary Educational Opportunities for Michigan High School Students

ERIC Educational Resources Information Center

Wozniak, Carl

2010-01-01

Administrator perspectives regarding current and potential increased participation in post-secondary educational opportunities by Michigan high school students were explored in this descriptive quantitative study. Targeted concerns included current institutional levels of involvement, personal knowledge concerning program rules and regulations,…

A Perspective on Effective Schools.

ERIC Educational Resources Information Center

Shulman, Lee S.

This address provides a historical perspective on the concept of school effectivenss and argues for an enlightened synthesis of normative and empirical values. The first part, "Early Images of Effective Schooling," reviews the evolution of discourse on school effectiveness since the turn of the century. Although the early discussions…

Recent Advances in Tumor Ablation for Hepatocellular Carcinoma

PubMed Central

Kang, Tae Wook; Rhim, Hyunchul

2015-01-01

Image-guided tumor ablation for early stage hepatocellular carcinoma (HCC) is an accepted non-surgical treatment that provides excellent local tumor control and favorable survival benefit. This review summarizes the recent advances in tumor ablation for HCC. Diagnostic imaging and molecular biology of HCC has recently undergone marked improvements. Second-generation ultrasonography (US) contrast agents, new computed tomography (CT) techniques, and liver-specific contrast agents for magnetic resonance imaging (MRI) have enabled the early detection of smaller and inconspicuous HCC lesions. Various imaging-guidance tools that incorporate imaging-fusion between real-time US and CT/MRI, that are now common for percutaneous tumor ablation, have increased operator confidence in the accurate targeting of technically difficult tumors. In addition to radiofrequency ablation (RFA), various therapeutic modalities including microwave ablation, irreversible electroporation, and high-intensity focused ultrasound ablation have attracted attention as alternative energy sources for effective locoregional treatment of HCC. In addition, combined treatment with RFA and chemoembolization or molecular agents may be able to overcome the limitation of advanced or large tumors. Finally, understanding of the biological mechanisms and advances in therapy associated with tumor ablation will be important for successful tumor control. All these advances in tumor ablation for HCC will result in significant improvement in the prognosis of HCC patients. In this review, we primarily focus on recent advances in molecular tumor biology, diagnosis, imaging-guidance tools, and therapeutic modalities, and refer to the current status and future perspectives for tumor ablation for HCC. PMID:26674766

Noninvasive Techniques for Intracranial Pressure Assessment: A Review from Aerospace Medicine Perspective

NASA Technical Reports Server (NTRS)

Hamilton, Douglas R.; Sargsyan, Ashot E.; Fogarty, Jennifer; Ebert, Douglas J. W.; Polk, J. D.

2010-01-01

Microgravity-induced changes in fluid distribution and other physiological factors due to space flight have been implicated as the cause of increased intracranial pressure (ICP) in a number of space crewmembers. The modest levels of ICP elevation and absence of severe symptoms in this group do not warrant invasive diagnostic interventions. However, the long-term trends and residual or consequential changes secondary to the observed ICP elevation in this group are not yet known. Therefore, close attention is needed to evaluate the potential techniques of noninvasively assessing ICP, including those feasible for in-flight use. Of particular interest is continuity between ground and in-flight testing, whereby data from the same or different techniques allow reasonably dependable estimation of ICP trends and responses. Methods: A thorough review of current literature, analysis of NASA data, and interviews with subject matter experts were conducted to construct a presentation that reflects the state of the art for noninvasive ICP measurement and monitoring. Results: Multiple imaging and non-imaging modalities are available to assess ICP in terrestrial clinical and experimental environments. Imaging alternatives include magnetic resonance imaging (MRI) and high-resolution sonography. Non-imaging techniques include transcranial Doppler, certain audiological methods, and venous ophthalmodynamometry, among others. Special functional techniques have been proposed recently that allow the use of advanced MRI methods to calculate ICP in addition to the acquisition of high-resolution images. Our data include many of these applications, with several cases of correlation with lumbar puncture, the invasive "gold standard" measurement of ICP.

Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives

PubMed Central

Ausoni, Simonetta; Boscolo-Rizzo, Paolo; Singh, Bhuvanesh; da Mosto, Maria Cristina; Spinato, Giacomo; Tirelli, Giancarlo; Spinato, Roberto; Azzarello, Giuseppe

2017-01-01

Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in head and neck squamous cell carcinoma (HNSCC) patients has improved only marginally during the last couple of decades, and optimal therapy has yet to be devised. Genomic complexity and intratumoral genetic heterogeneity may contribute to treatment resistance and the propensity for locoregional recurrence. Countering this, demands a significant effort from both basic and clinical scientists in the search for more-effective targeted therapies. Recent genomewide studies have provided valuable insights into the genetic basis of HNSCC, uncovering potential new therapeutic opportunities. In addition, several studies have elucidated how inflammatory, immune, and stromal cells contribute to the particular properties of these neoplasms. In the present review, we introduce recent findings on genomic aberrations resulting from whole-genome sequencing of HNSCC, we discuss how the particular microenvironment affects the pathogenesis of this disease, and we describe clinical trials exploring new perspectives on the use of combined genetic and cellular targeted therapies. PMID:27194534

Venus - 3D Perspective View of Maat Mons

NASA Technical Reports Server (NTRS)

1992-01-01

Maat Mons is displayed in this computer generated three-dimensional perspective of the surface of Venus. The viewpoint is located 634 kilometers (393 miles) north of Maat Mons at an elevation of 3 kilometers (2 miles) above the terrain. Lava flows extend for hundreds of kilometers across the fractured plains shown in the foreground, to the base of Maat Mons. The view is to the south with the volcano Maat Mons appearing at the center of the image on the horizon and rising to almost 5 kilometers (3 miles) above the surrounding terrain. Maat Mons is located at approximately 0.9 degrees north latitude, 194.5 degrees east longitude with a peak that ascends to 8 kilometers (5 miles) above the mean surface. Maat Mons is named for an Egyptian Goddess of truth and justice. Magellan synthetic aperture radar data is combined with radar altimetry to develop a three-dimensional map of the surface. The vertical scale in this perspective has been exaggerated 10 times. Rays cast in a computer intersect the surface to crate a three-dimensional perspective view. Simulated color and a digital elevation map developed by the U.S. Geological Survey are used to enhance small-scale structure. The simulated hues are based on color images recorded by the Soviet Venera 13 and 14 spacecraft. The image was produced by the Solar System Visualization project and the Magellan Science team at the JPL Multimission Image Processing Laboratory and is a single frame from a video released at the April 22, 1992 news conference.

A Presentation of Spectacular Visualizations

NASA Technical Reports Server (NTRS)

Hasler, Fritz; Einaudi, Franco (Technical Monitor)

2000-01-01

The NASA/NOAA/AMS Earth Science Electronic Theater presents Earth science observations and visualizations in a historical perspective. Fly in from outer space to Florida and the KSC Visitor's Center. Go back to the early weather satellite images from the 1960s see them contrasted with the latest International global satellite weather movies including killer hurricanes and tornadic thunderstorms. See the latest spectacular images from NASA and the National Oceanic and Atmospheric Administration (NOAA) remote sensing missions like the Geostationary Operational Environmental Satellites (GOES), NOAA, Tropical Rainfall Measuring Mission (TRMM), SeaWiFS, Landsat7, and new Terra which will be visualized with state-of-the art tools. Shown in High Definition TV resolution (2048 x 768 pixels) are visualizations of hurricanes Lenny, Floyd, Georges, Mitch, Fran, and Linda. See visualizations featured on covers of magazines like Newsweek, TIME, National Geographic, Popular Science, and on National and International Network TV. New Digital Earth visualization tools allow us to roam and zoom through massive global images including a Landsat tour of the US, with drill-downs into major cities using one meter resolution spy-satellite technology from the Space Imaging IKONOS satellite. Spectacular new visualizations of the global atmosphere and oceans are shown. See massive dust storms sweeping across Africa. See ocean vortexes and currents that bring up the nutrients to feed tiny plankton and draw the fish, giant whales and fisherman. See the how the ocean blooms in response to these currents and El Nino/La Nina climate changes. The demonstration is interactively driven by a SGI Octane Graphics Supercomputer with dual CPUs, 5 Gigabytes of RAM and Terabyte disk using two projectors across the super sized Universe Theater panoramic screen.

Nonlinear excitation fluorescence microscopy: source considerations for biological applications

NASA Astrophysics Data System (ADS)

Wokosin, David L.

2008-02-01

Ultra-short-pulse solid-state laser sources have improved contrast within fluorescence imaging and also opened new windows of investigation in biological imaging applications. Additionally, the pulsed illumination enables harmonic scattering microscopy which yields intrinsic structure, symmetry and contrast from viable embryos, cells and tissues. Numerous human diseases are being investigated by the combination of (more) intact dynamic tissue imaging of cellular function with gene-targeted specificity and electrophysiology context. The major limitation to more widespread use of multi-photon microscopy has been the complete system cost and added complexity above and beyond commercial camera and confocal systems. The current status of all-solid-state ultrafast lasers as excitation sources will be reviewed since these lasers offer tremendous potential for affordable, reliable, "turnkey" multiphoton imaging systems. This effort highlights the single box laser systems currently commercially available, with defined suggestions for the ranges for individual laser parameters as derived from a biological and fluorophore limited perspective. The standard two-photon dose is defined by 800nm, 10mW, 200fs, and 80Mhz - at the sample plane for tissue culture cells, i.e. after the full scanning microscope system. Selected application-derived excitation wavelengths are well represented by 700nm, 780nm, ~830nm, ~960nm, 1050nm, and 1250nm. Many of the one-box lasers have fixed or very limited excitation wavelengths available, so the lasers will be lumped near 780nm, 800nm, 900nm, 1050nm, and 1250nm. The following laser parameter ranges are discussed: average power from 200mW to 2W, pulse duration from 70fs to 700fs, pulse repetition rate from 20MHz to 200MHz, with the laser output linearly polarized with an extinction ratio at least 100:1.

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

PubMed Central

dos Santos, Valentin Aranha; Schmetterer, Leopold; Triggs, Graham J.; Leitgeb, Rainer A.; Gröschl, Martin; Messner, Alina; Schmidl, Doreen; Garhofer, Gerhard; Aschinger, Gerold; Werkmeister, René M.

2016-01-01

In optical coherence tomography (OCT), the axial resolution is directly linked to the coherence length of the employed light source. It is currently unclear if OCT allows measuring thicknesses below its axial resolution value. To investigate spectral-domain OCT imaging in the super-resolution regime, we derived a signal model and compared it with the experiment. Several island thin film samples of known refractive indices and thicknesses in the range 46 – 163 nm were fabricated and imaged. Reference thickness measurements were performed using a commercial atomic force microscope. In vivo measurements of the tear film were performed in 4 healthy subjects. Our results show that quantitative super-resolved thickness measurement can be performed using OCT. In addition, we report repeatable tear film lipid layer visualization. Our results provide a novel interpretation of the OCT axial resolution limit and open a perspective to deeper extraction of the information hidden in the coherence volume. PMID:27446696

Real-world visual statistics and infants' first-learned object names

PubMed Central

Clerkin, Elizabeth M.; Hart, Elizabeth; Rehg, James M.; Yu, Chen

2017-01-01

We offer a new solution to the unsolved problem of how infants break into word learning based on the visual statistics of everyday infant-perspective scenes. Images from head camera video captured by 8 1/2 to 10 1/2 month-old infants at 147 at-home mealtime events were analysed for the objects in view. The images were found to be highly cluttered with many different objects in view. However, the frequency distribution of object categories was extremely right skewed such that a very small set of objects was pervasively present—a fact that may substantially reduce the problem of referential ambiguity. The statistical structure of objects in these infant egocentric scenes differs markedly from that in the training sets used in computational models and in experiments on statistical word-referent learning. Therefore, the results also indicate a need to re-examine current explanations of how infants break into word learning. This article is part of the themed issue ‘New frontiers for statistical learning in the cognitive sciences’. PMID:27872373

Trapped children: popular images of children with autism in the 1960s and 2000s.

PubMed

Sarrett, Jennifer C

2011-06-01

The lay public inherits much of its information about disability and mental illness through the media, which often relies on information from popular scientific works. Autism, as it was defined during the dominance of psychogenic paradigms of mental illness, generated certain tropes surrounding it, many of which have been popularized through media representations. Often inaccurate, these tropes have persisted into contemporary times despite a paradigmatic shift from psychogenic to biological explanations and treatments for mental illness. The current article examines images and articles of children with autism from the 1960s and the early 2000s in major news media and scientific literature to highlight the persistence of themes of fragmentation and the imprisonment of children with autism. While these themes have persisted in psychological and media literature, narratives of people with autism and their families often present a different perspective. This results in two divergent 'realities' of autism being disseminated into the general public.

Our unacknowledged ancestors: dream theorists of antiquity, the middle ages, and the renaissance.

PubMed

Rupprecht, C S

1990-06-01

Exploring the dream world from a modern, or post-modern, perspective, especially through the lens of contemporary technologies, often leads us as researchers to see ourselves as engaged in a new and revolutionary discourse. In fact, this self-image is a profoundly ahistorical one, because it ignores the contributions of ancient, medieval and Renaissance oneirologists who wrote extensively, albeit in different terms and images of lucidity, prerecognition, day residue, wish fulfillment, incubation, problem solving, REM, obe, and the collective unconscious. There are also analogues in these early accounts to anxiety, recurrent, mirror, telepathic, shared, flying, and death dreams. Dream interpretation through music, analysis of dream as narrative, sophisticated theories about memory and language and symbolization are all part of the tradition. Further, early texts pose many issues in sleep and dream research which are not currently being pursued. We dream workers of the late twentieth century should therefore fortify ourselves with knowledge of the oneiric past as one important way to enhance our dream work in the twenty-first century.

Applications of Remote Sensing to Alien Invasive Plant Studies

PubMed Central

Huang, Cho-ying; Asner, Gregory P.

2009-01-01

Biological invasions can affect ecosystems across a wide spectrum of bioclimatic conditions. Therefore, it is often important to systematically monitor the spread of species over a broad region. Remote sensing has been an important tool for large-scale ecological studies in the past three decades, but it was not commonly used to study alien invasive plants until the mid 1990s. We synthesize previous research efforts on remote sensing of invasive plants from spatial, temporal and spectral perspectives. We also highlight a recently developed state-of-the-art image fusion technique that integrates passive and active energies concurrently collected by an imaging spectrometer and a scanning-waveform light detection and ranging (LiDAR) system, respectively. This approach provides a means to detect the structure and functional properties of invasive plants of different canopy levels. Finally, we summarize regional studies of biological invasions using remote sensing, discuss the limitations of remote sensing approaches, and highlight current research needs and future directions. PMID:22408558

[Diversity and meaning of masculine phallic palaeolithic images in Western Europe].

PubMed

Angulo Cuesta, J; García Diez, M

2006-03-01

The archaeological record necessary to understand the sexual behaviour of our ancestors from Upper Palaeolithic (38.000-8.500 B.C.) is limited. Traditionally the ethnographic information about sexuality and the relations between sexes derived from comparitions with current primitive human groups have been considered very important, although they have been evaluated more from a social and anthropological rather than biological perspective. Ice age art art, both rock and portable, is a reflection of the behaviour of palaeolithic human groups. The purpose of this text focuses on understanding the types of representations and sexual attitudes during the Upper Palaeolithic, as reflected from masculine images of phallic character. Practices of foreskin retraction, some phalli possibly circumcised, copulative acts, expressions of masturbation, instruments that have been likely been used for masturbation and other sexual scenes, some of which are difficult to interpretate, show that the sexual behaviour of the human groups of the Upper Palaeolithic were similar to ours, both from a biological and physiological viewpoint.

Developing a Fluorescent Toolbox To Shed Light on the Mysteries of RNA.

PubMed

Alexander, Seth C; Devaraj, Neal K

2017-10-03

Technologies that detect and image RNA have illuminated the complex roles played by RNA, redefining the traditional and superficial role first outlined by the central dogma of biology. Because there is such a wide diversity of RNA structure arising from an assortment of functions within biology, a toolbox of approaches have emerged for investigation of this important class of biomolecules. These methods are necessary to detect and elucidate the localization and dynamics of specific RNAs and in doing so unlock our understanding of how RNA dysregulation leads to disease. Current methods for detecting and imaging RNA include in situ hybridization techniques, fluorescent aptamers, RNA binding proteins fused to fluorescent reporters, and covalent labeling strategies. Because of the inherent diversity of these methods, each approach comes with a set of strengths and limitations that leave room for future improvement. This perspective seeks to highlight the most recent advances and remaining challenges for the wide-ranging toolbox of technologies that illuminate RNA's contribution to cellular complexity.

Capabilities and prospects of the East Asia Very Long Baseline Interferometry Network

NASA Astrophysics Data System (ADS)

An, T.; Sohn, B. W.; Imai, H.

2018-02-01

The very long baseline interferometry (VLBI) technique offers angular resolutions superior to any other instruments at other wavelengths, enabling unique science applications of high-resolution imaging of radio sources and high-precision astrometry. The East Asia VLBI Network (EAVN) is a collaborative effort in the East Asian region. The EAVN currently consists of 21 telescopes with diverse equipment configurations and frequency setups, allowing flexible subarrays for specific science projects. The EAVN provides the highest resolution of 0.5 mas at 22 GHz, allowing the fine imaging of jets in active galactic nuclei, high-accuracy astrometry of masers and pulsars, and precise spacecraft positioning. The soon-to-be-operational Five-hundred-meter Aperture Spherical radio Telescope (FAST) will open a new era for the EAVN. This state-of-the-art VLBI array also provides easy access to and crucial training for the burgeoning Asian astronomical community. This Perspective summarizes the status, capabilities and prospects of the EAVN.

International Symposium on Remote Sensing of Environment, 17th, University of Michigan, Ann Arbor, MI, May 9-13, 1983, Proceedings. Volumes 1, 2 & 3

NASA Technical Reports Server (NTRS)

1984-01-01

The collection, processing, and analysis of remote-sensing data from ground-based, airborne, and spaceborne instruments for application to the monitoring and management of the earth and environment and resources are examined in reviews and reports, some in summary form. Subject areas covered include US policy and directions on remote sensing (RS); the future of terrestrial RS from space; RS of land, oceans, and atmosphere from a global perspective; RS in hydrological modeling; microprocessing technology; array processors; geobased information systems; artificial intelligence; the Shuttle imaging radar; and current results from Landsat-4. Among the specific topics discussed are RS application to hydrocarbon exploration, airborne gamma-radiation assessment of snow water equivalent, surface-vegetation-biomass modeling from AVHRR and Landsat data, Landsat imagery of Mediterranean pollution, fast two-dimensional filtering of thermal-scanner data, RS of severe convective storms, registration of rotated images by invariant moments, and the geometric accuracy of Landsat-4 Thematic-Mapper P-tapes.

Student Perspectives of Imaging Anatomy in Undergraduate Medical Education

ERIC Educational Resources Information Center

Machado, Jorge Americo Dinis; Barbosa, Joselina Maria Pinto; Ferreira, Maria Amelia Duarte

2013-01-01

Radiological imaging is gaining relevance in the acquisition of competencies in clinical anatomy. The aim of this study was to evaluate the perceptions of medical students on teaching/learning of imaging anatomy as an integrated part of anatomical education. A questionnaire was designed to evaluate the perceptions of second-year students…

Enhancing Image Findability through a Dual-Perspective Navigation Framework

ERIC Educational Resources Information Center

Lin, Yi-Ling

2013-01-01

This dissertation focuses on investigating whether users will locate desired images more efficiently and effectively when they are provided with information descriptors from both experts and the general public. This study develops a way to support image finding through a human-computer interface by providing subject headings and social tags about…

Location of Spirit's Home

NASA Technical Reports Server (NTRS)

2004-01-01

This image shows where Earth would set on the martian horizon from the perspective of the Mars Exploration Rover Spirit if it were facing northwest atop its lander at Gusev Crater. Earth cannot be seen in this image, but engineers have mapped its location. This image mosaic was taken by the hazard-identification camera onboard Spirit.

Advising on Career Image: Perspectives, Practice and Politics

ERIC Educational Resources Information Center

Yates, Julia; Hooley, Tristram

2018-01-01

This article analyses qualitative data gathered from a survey of career practitioners on the issue of career image (n = 355, 75% female, 89% white and 78% from the UK). Findings reveal three key themes which represent how career image relates to practitioners' values and beliefs, how practitioners make decisions about whether to address the topic…

Factors Affecting Corporate Image from the Perspective of Distance Learning Students in Public Higher Education Institutions

ERIC Educational Resources Information Center

da Costa, Fábio Reis; Pelissari, Anderson Soncini

2016-01-01

New information technologies enable different interactions in the educational environment, affecting how the image of educational institutions adopting distance-learning programmes is perceived. This article identifies factors affecting the perception of corporate image from the viewpoint of distance-learning students at public higher education…

Textbook Images: How Do They Invite Students into Physics?

ERIC Educational Resources Information Center

Bungum, Berit

2013-01-01

This paper presents a study of images in Norwegian physics textbooks for upper secondary school, and how they invite students into physics by means of visual communication. The concept of "framing" is used to investigate how the perspective in the image provides a sense of participation. It is found that older textbooks, where objects…

Historical Perspectives on the Current Education Reforms.

ERIC Educational Resources Information Center

Ravitch, Diane, Ed.; Vinovskis, Maris, Ed.

This document contains 14 individual papers by prominent scholars who provide a historical perspective on current educational reforms. The three essays in part 1 examine some of the major changes in educational development and reform. These include: (1) "Antiquarianism and American Education: Assimilation, Adjustment, Access" (Patricia Graham);…

Volumetric visualization algorithm development for an FPGA-based custom computing machine

NASA Astrophysics Data System (ADS)

Sallinen, Sami J.; Alakuijala, Jyrki; Helminen, Hannu; Laitinen, Joakim

1998-05-01

Rendering volumetric medical images is a burdensome computational task for contemporary computers due to the large size of the data sets. Custom designed reconfigurable hardware could considerably speed up volume visualization if an algorithm suitable for the platform is used. We present an algorithm and speedup techniques for visualizing volumetric medical CT and MR images with a custom-computing machine based on a Field Programmable Gate Array (FPGA). We also present simulated performance results of the proposed algorithm calculated with a software implementation running on a desktop PC. Our algorithm is capable of generating perspective projection renderings of single and multiple isosurfaces with transparency, simulated X-ray images, and Maximum Intensity Projections (MIP). Although more speedup techniques exist for parallel projection than for perspective projection, we have constrained ourselves to perspective viewing, because of its importance in the field of radiotherapy. The algorithm we have developed is based on ray casting, and the rendering is sped up by three different methods: shading speedup by gradient precalculation, a new generalized version of Ray-Acceleration by Distance Coding (RADC), and background ray elimination by speculative ray selection.

Applications of 3D printing in cardiovascular diseases.

PubMed

Giannopoulos, Andreas A; Mitsouras, Dimitris; Yoo, Shi-Joon; Liu, Peter P; Chatzizisis, Yiannis S; Rybicki, Frank J

2016-12-01

3D-printed models fabricated from CT, MRI, or echocardiography data provide the advantage of haptic feedback, direct manipulation, and enhanced understanding of cardiovascular anatomy and underlying pathologies. Reported applications of cardiovascular 3D printing span from diagnostic assistance and optimization of management algorithms in complex cardiovascular diseases, to planning and simulating surgical and interventional procedures. The technology has been used in practically the entire range of structural, valvular, and congenital heart diseases, and the added-value of 3D printing is established. Patient-specific implants and custom-made devices can be designed, produced, and tested, thus opening new horizons in personalized patient care and cardiovascular research. Physicians and trainees can better elucidate anatomical abnormalities with the use of 3D-printed models, and communication with patients is markedly improved. Cardiovascular 3D bioprinting and molecular 3D printing, although currently not translated into clinical practice, hold revolutionary potential. 3D printing is expected to have a broad influence in cardiovascular care, and will prove pivotal for the future generation of cardiovascular imagers and care providers. In this Review, we summarize the cardiovascular 3D printing workflow, from image acquisition to the generation of a hand-held model, and discuss the cardiovascular applications and the current status and future perspectives of cardiovascular 3D printing.

High-throughput electrical characterization for robust overlay lithography control

NASA Astrophysics Data System (ADS)

Devender, Devender; Shen, Xumin; Duggan, Mark; Singh, Sunil; Rullan, Jonathan; Choo, Jae; Mehta, Sohan; Tang, Teck Jung; Reidy, Sean; Holt, Jonathan; Kim, Hyung Woo; Fox, Robert; Sohn, D. K.

2017-03-01

Realizing sensitive, high throughput and robust overlay measurement is a challenge in current 14nm and advanced upcoming nodes with transition to 300mm and upcoming 450mm semiconductor manufacturing, where slight deviation in overlay has significant impact on reliability and yield1). Exponentially increasing number of critical masks in multi-patterning lithoetch, litho-etch (LELE) and subsequent LELELE semiconductor processes require even tighter overlay specification2). Here, we discuss limitations of current image- and diffraction- based overlay measurement techniques to meet these stringent processing requirements due to sensitivity, throughput and low contrast3). We demonstrate a new electrical measurement based technique where resistance is measured for a macro with intentional misalignment between two layers. Overlay is quantified by a parabolic fitting model to resistance where minima and inflection points are extracted to characterize overlay control and process window, respectively. Analyses using transmission electron microscopy show good correlation between actual overlay performance and overlay obtained from fitting. Additionally, excellent correlation of overlay from electrical measurements to existing image- and diffraction- based techniques is found. We also discuss challenges of integrating electrical measurement based approach in semiconductor manufacturing from Back End of Line (BEOL) perspective. Our findings open up a new pathway for accessing simultaneous overlay as well as process window and margins from a robust, high throughput and electrical measurement approach.

Venus - 3D Perspective View of Eistla Regio

NASA Technical Reports Server (NTRS)

1991-01-01

A portion of western Eistla Regio is displayed in this three-dimensional perspective view of the surface of Venus. The viewpoint is located 1,310 kilometers (812 miles) southwest of Gula Mons at an elevation of 0.78 kilometer (0.48 mile). The view is to the northeast with Gula Mons appearing on the horizon. Gula Mons, a 3 kilometer (1.86 mile) high volcano, is located at approximately 22 degrees north latitude, 359 degrees east longitude. The impact crater Cunitz, named for the astronomer and mathematician Maria Cunitz, is visible in the center of the image. The crater is 48.5 kilometers (30 miles) in diameter and is 215 kilometers (133 miles) from the viewer's position. Magellan synthetic aperture radar data is combined with radar altimetry to develop a three-dimensional map of the surface. Rays cast in a computer intersect the surface to create a three-dimensional perspective view. Simulated color and a digital elevation map developed by the U.S. Geological Survey, are used to enhance small-scale structure. The simulated hues are based on color images recorded by the Soviet Venera 13 and 14 spacecraft. The image was produced at the JPL Multimission Image Processing Laboratory and is a single frame from a video released at the March 5, 1991, JPL news conference.

Altered Perspectives: Immersive Environments

NASA Astrophysics Data System (ADS)

Shipman, J. S.; Webley, P. W.

2016-12-01

Immersive environments provide an exciting experiential technology to visualize the natural world. Given the increasing accessibility of 360o cameras and virtual reality headsets we are now able to visualize artistic principles and scientific concepts in a fully immersive environment. The technology has become popular for photographers as well as designers, industry, educational groups, and museums. Here we show a sci-art perspective on the use of optics and light in the capture and manipulation of 360o images and video of geologic phenomena and cultural heritage sites in Alaska, England, and France. Additionally, we will generate intentionally altered perspectives to lend a surrealistic quality to the landscapes. Locations include the Catacombs of Paris, the Palace of Versailles, and the Northern Lights over Fairbanks, Alaska. Some 360o view cameras now use small portable dual lens technology extending beyond the 180o fish eye lens previously used, providing better coverage and image quality. Virtual reality headsets range in level of sophistication and cost, with the most affordable versions using smart phones and Google Cardboard viewers. The equipment used in this presentation includes a Ricoh Theta S spherical imaging camera. Here we will demonstrate the use of 360o imaging with attendees being able to be part of the immersive environment and experience our locations as if they were visiting themselves.

En-face Flying Spot OCT/Ophthalmoscope

NASA Astrophysics Data System (ADS)

Rosen, Richard B.; Garcia, Patricia; Podoleanu, Adrian Gh.; Cucu, Radu; Dobre, George; Trifanov, Irina; van Velthoven, Mirjam E. J.; de Smet, Marc D.; Rogers, John A.; Hathaway, Mark; Pedro, Justin; Weitz, Rishard

This is a review of a technique for high-resolution imaging of the eye that allows multiple sample sectioning perspectives with different axial resolutions. The technique involves the flying spot approach employed in confocal scanning laser ophthalmoscopy which is extended to OCT imaging via time domain en face fast lateral scanning. The ability of imaging with multiple axial resolutions stimulated the development of the dual en face OCT-confocal imaging technology. Dual imaging also allows various other imaging combinations, such as OCT with confocal microscopy for imaging the eye anterior segment and OCT with fluorescence angiography imaging.

Retrieval and classification of food images.

PubMed

Farinella, Giovanni Maria; Allegra, Dario; Moltisanti, Marco; Stanco, Filippo; Battiato, Sebastiano

2016-10-01

Automatic food understanding from images is an interesting challenge with applications in different domains. In particular, food intake monitoring is becoming more and more important because of the key role that it plays in health and market economies. In this paper, we address the study of food image processing from the perspective of Computer Vision. As first contribution we present a survey of the studies in the context of food image processing from the early attempts to the current state-of-the-art methods. Since retrieval and classification engines able to work on food images are required to build automatic systems for diet monitoring (e.g., to be embedded in wearable cameras), we focus our attention on the aspect of the representation of the food images because it plays a fundamental role in the understanding engines. The food retrieval and classification is a challenging task since the food presents high variableness and an intrinsic deformability. To properly study the peculiarities of different image representations we propose the UNICT-FD1200 dataset. It was composed of 4754 food images of 1200 distinct dishes acquired during real meals. Each food plate is acquired multiple times and the overall dataset presents both geometric and photometric variabilities. The images of the dataset have been manually labeled considering 8 categories: Appetizer, Main Course, Second Course, Single Course, Side Dish, Dessert, Breakfast, Fruit. We have performed tests employing different representations of the state-of-the-art to assess the related performances on the UNICT-FD1200 dataset. Finally, we propose a new representation based on the perceptual concept of Anti-Textons which is able to encode spatial information between Textons outperforming other representations in the context of food retrieval and Classification. Copyright © 2016 Elsevier Ltd. All rights reserved.

Perspective View with Landsat Overlay, San Jose, Costa Rica

NASA Technical Reports Server (NTRS)

2002-01-01

This perspective view shows the capital city of San Jose, Costa Rica, the gray area in the center of the image. The view is toward the northwest with the Pacific Ocean in the distance and shows a portion of the Meseta Central (Central Valley), home to about a third of Costa Rica's population.

Like much of Central America, Costa Rica is generally cloud covered, so very little satellite imagery is available. The ability of the Shuttle Radar Topography Mission (SRTM) instrument to penetrate clouds and make three-dimensional measurements will allow generation of the first complete high-resolution topographic map of the entire region. These data were used to generate the image.

This three-dimensional perspective view was generated using elevation data from SRTM and an enhanced false-color Landsat 7 satellite image. Colors are from Landsat bands 5, 4, and 2 as red, green and blue, respectively. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter resolution of most Landsat images and will substantially help in analyses of the large and growing Landsat image archive. The Landsat 7 Thematic Mapper image used here was provided to the SRTM by the United States Geological Survey, Earth Resources Observation Systems (EROS) Data Center, Sioux Falls, S.D.

Elevation data used in this image was acquired by the SRTM aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

Size: scale varies in this perspective image Location: 10.0 degrees North latitude, 83.8 degrees West longitude Orientation: looking Northwest Image Data: Landsat Bands 5, 4, 3 as red, green, blue respectively Original Data Resolution: SRTM 30 meters (99 feet) Date Acquired: February 2000 (SRTM)

Flute Physics from a Flutist's Perspective

ERIC Educational Resources Information Center

Boysen, Erika; Ruiz, Michael J.

2017-01-01

The basic physics of the flute is presented from the perspective of a professional flutist. The flutist can control loudness, pitch and to some extent timbre. Oscilloscope images are provided to compare changes in these three fundamental sound characteristics. Readers can view a video (Ruiz 2017 "Video: The Flute"…

Visions to Guide Performance: A Typology of Multiple Future Organizational Images

ERIC Educational Resources Information Center

Margolis, Sheila L.; Hansen, Carol D.

2003-01-01

Organizational performance is highly influenced by how employees envision the future. To date, many scholars have emphasized the importance of an overarching future vision that unites all stakeholders, while acknowledging the presence of divergent perspectives among members. This variety in perspectives may be further complicated in organizations…

Manipulating recall vantage perspective of intrusive memories in dysphoria.

PubMed

Williams, Alishia D; Moulds, Michelle L

2008-10-01

The current study attempted to experimentally manipulate mode of recall (field, observer perspective) in a sample of mildly dysphoric participants (N=134) who reported a distressing intrusive memory of negative autobiographical event. Specifically, the current study sought to ascertain whether shifting participants into a converse perspective would have differential effects on the reported experience of their memory. Results indicated that shifting participants from a field to an observer perspective resulted in decreased experiential ratings: specifically, reduced distress and vividness. Also, as anticipated, the converse shift in perspective (from observer to field) did not lead to a corresponding increase in experiential ratings, but did result in reduced ratings of observation and a trend was observed for decreased levels of detachment. The findings support the notion that recall perspective has a functional role in the regulation of intrusion-related distress and represents a cognitive avoidance mechanism.

When Perspective Taking Creates a Motivational Threat: The Case of Conservatism, Same-Sex Sexual Behavior, and Anti-Gay Attitudes.

PubMed

Mooijman, Marlon; Stern, Chadly

2016-06-01

Taking another person's perspective has generally been found to foster positive attitudes. We propose that perspective taking can lead to more negative attitudes when people imagine an experience that threatens their current motivations and goals. We test this idea by examining how taking the perspective of a male same-sex couple influences political conservatives' attitudes. Across four studies, we demonstrate that (a) the extent to which conservatives (but not liberals) imagine same-sex sexual behavior predicts more anti-gay attitudes, (b) this effect is in part attributable to conservatives experiencing greater disgust, and (c) having conservatives reappraise disgust as not necessarily signaling the threat of disease eliminates this effect. These findings indicate that perspective taking can foster negative attitudes when the content of perspective taking threatens current motivations. The proposed ideas provide unique insights toward developing a more comprehensive framework of how perspective taking shapes attitudes. © 2016 by the Society for Personality and Social Psychology, Inc.

Diagnostic imaging to detect and evaluate response to therapy in bone metastases from prostate cancer: current modalities and new horizons.

PubMed

Evangelista, Laura; Bertoldo, Francesco; Boccardo, Francesco; Conti, Giario; Menchi, Ilario; Mungai, Francesco; Ricardi, Umberto; Bombardieri, Emilio

2016-07-01

Different therapeutic options for the management of prostate cancer (PC) have been developed, and some are successful in providing crucial improvement in both survival and quality of life, especially in patients with metastatic castration-resistant PC. In this scenario, diverse combinations of radiopharmaceuticals (for targeting bone, cancer cells and receptors) and nuclear medicine modalities (e.g. bone scan, SPECT, SPECT/CT, PET and PET/CT) are now available for imaging bone metastases. Some radiopharmaceuticals are approved, currently available and used in the routine clinical setting, while others are not registered and are still under evaluation, and should therefore be considered experimental. On the other hand, radiologists have other tools, in addition to CT, that can better visualize bone localization and medullary involvement, such as multimodal MRI. In this review, the authors provide an overview of current management of advanced PC and discuss the choice of diagnostic modality for the detection of metastatic skeletal lesions in different phases of the disease. In addition to detection of bone metastases, the evaluation of response to therapy is another critical issue, since it remains one of the most important open questions that a multidisciplinary team faces when optimizing the management of PC. The authors emphasize the role of nuclear modalities that can presently be used in clinical practice, and also look at future perspectives based on relevant clinical data with novel radiopharmaceuticals.

[EU law on marketing authorization of medicines. History, current state of development and perspectives].

PubMed

Nettesheim, Martin

2008-07-01

The article describes the development of EU policies and regulations on the marketing authorization of medicines. First, it describes the changing perspective of the EU towards the regulation of such authorizations. While its original focus was on the liberalization of national markets, it has today assumed overarching political responsibility for the development and marketing of medicines. Second, the article describes the current, rather fragmented regulatory system. Finally, political perspectives on the integration of markets for medicines are developed.

3-D Perspective View, Miquelon and Saint Pierre Islands

NASA Image and Video Library

2000-03-16

This image shows Miquelon and Saint Pierre Islands, located south of Newfoundland, Canada. These islands, along with five smaller islands, are a self-governing territory of France. North is in the top right corner of the image.

Ghost microscope imaging system from the perspective of coherent-mode representation

NASA Astrophysics Data System (ADS)

Shen, Qian; Bai, Yanfeng; Shi, Xiaohui; Nan, Suqin; Qu, Lijie; Li, Hengxing; Fu, Xiquan

2018-03-01

The coherent-mode representation theory of partially coherent fields is firstly used to analyze a two-arm ghost microscope imaging system. It is shown that imaging quality of the generated images depend crucially on the distribution of the decomposition coefficients of the object imaged when the light source is fixed. This theory is also suitable for demonstrating the effects from the distance the object is moved away from the original plane on imaging quality. Our results are verified theoretically and experimentally.

Drawing asthma: An exploration of patients' perceptions and experiences.

PubMed

Cheung, Melissa Mei Yin; Saini, Bandana; Smith, Lorraine

2018-03-01

As an art form, drawings can facilitate the tangible expression of patients' inner images and feelings in a range of health conditions. However, there are currently no published studies investigating adults' perspectives of asthma using drawings. This study aimed to explore how adults' drawings illustrate their perceptions and experiences of asthma. Adults with asthma participated in a one-on-one drawing activity. Analysis was grounded in the participants' accounts of their drawing, which were examined alongside the relevant image. A coding approach was used to cluster thematic material and map the data according to the Common-Sense Model of Self-Regulation (CSM). Eighteen participants took part. Three themes emerged: (1) asthma is constrictive and restrictive, (2) feeling alone, feeling different, and (3) the life journey of asthma. The drawings aligned with several domains of the CSM, in particular consequences. The images drawn by the participants and their subsequent discussions highlighted the prominence of the emotional burden of asthma. The drawings provided powerful and evocative communication of the experience of asthma. Future research using drawings can further both healthcare professionals' and patients' understanding of the physical, social and emotional demands of living with asthma, and support the development of asthma self-management practices.

Healthcare Policy Statement on the Utility of Coronary Computed Tomography for Evaluation of Cardiovascular Conditions and Preventive Healthcare: From the Health Policy Working Group of the Society of Cardiovascular Computed Tomography.

PubMed

Slim, Ahmad M; Jerome, Scott; Blankstein, Ron; Weigold, Wm Guy; Patel, Amit R; Kalra, Dinesh K; Miller, Ryan; Branch, Kelley; Rabbat, Mark G; Hecht, Harvey; Nicol, Edward D; Villines, Todd C; Shaw, Leslee J

The rising cost of healthcare is prompting numerous policy and advocacy discussions regarding strategies for constraining growth and creating a more efficient and effective healthcare system. Cardiovascular imaging is central to the care of patients at risk of, and living with, heart disease. Estimates are that utilization of cardiovascular imaging exceeds 20 million studies per year. The Society of Cardiovascular CT (SCCT), alongside Rush University Medical Center, and in collaboration with government agencies, regional payers, and industry healthcare experts met in November 2016 in Chicago, IL to evaluate obstacles and hurdles facing the cardiovascular imaging community and how they can contribute to efficacy while maintaining or even improving outcomes and quality. The summit incorporated inputs from payers, providers, and patients' perspectives, providing a platform for all voices to be heard, allowing for a constructive dialogue with potential solutions moving forward. This article outlines the proceedings from the summit, with a detailed review of past hurdles, current status, and potential solutions as we move forward in an ever-changing healthcare landscape. Copyright © 2017 Society of Cardiovascular Computed Tomography. All rights reserved.

Bioluminescence imaging: a shining future for cardiac regeneration

PubMed Central

Roura, Santiago; Gálvez-Montón, Carolina; Bayes-Genis, Antoni

2013-01-01

Advances in bioanalytical techniques have become crucial for both basic research and medical practice. One example, bioluminescence imaging (BLI), is based on the application of natural reactants with light-emitting capabilities (photoproteins and luciferases) isolated from a widespread group of organisms. The main challenges in cardiac regeneration remain unresolved, but a vast number of studies have harnessed BLI with the discovery of aequorin and green fluorescent proteins. First described in the luminous hydromedusan Aequorea victoria in the early 1960s, bioluminescent proteins have greatly contributed to the design and initiation of ongoing cell-based clinical trials on cardiovascular diseases. In conjunction with advances in reporter gene technology, BLI provides valuable information about the location and functional status of regenerative cells implanted into numerous animal models of disease. The purpose of this review was to present the great potential of BLI, among other existing imaging modalities, to refine effectiveness and underlying mechanisms of cardiac cell therapy. We recount the first discovery of natural primary compounds with light-emitting capabilities, and follow their applications to bioanalysis. We also illustrate insights and perspectives on BLI to illuminate current efforts in cardiac regeneration, where the future is bright. PMID:23402217

An evaluation of websites to help neurosurgical trainees learn histopathology.

PubMed

Jeffree, R L

2013-10-01

Knowledge of histopathology is essential for good neurosurgical practice but current pressures on neurosurgical trainees' time restrict opportunities to learn histopathology by traditional methods. The internet offers a possible alternative resource. The aim of this project was to assess the existing, free, internet-based resources for learning histology and histopathology, from the perspective of a neurosurgical trainee. English language websites were evaluated by an expert, and by neurosurgical trainees, for the range of content, academic credibility, quality of the histopathological images, quality of supporting content, educational features and the usability. Thirty-nine websites were examined in detail by the author. Although many websites were useful, no individual website met all the requirements. Five neuropathology websites were clearly superior to the others. These were then assessed by neurosurgical trainees. The results of the assessment, a brief resume of each website, and the characteristics of a good website for the surgical trainees to learn pathology are discussed. The best websites featured a large number of high-quality images, accurate, detailed clinical and pathophysiological information, labelling or description of individual images, and organisation by organ system. Free internet sites can offer a valuable learning resource to supplement textbooks and clinical pathology sessions.

Advances in functional brain imaging technology and developmental neuro-psychology: their applications in the Jungian analytic domain.

PubMed

Petchkovsky, Leon

2017-06-01

Analytical psychology shares with many other psychotherapies the important task of repairing the consequences of developmental trauma. The majority of analytic patients come from compromised early developmental backgrounds: they may have experienced neglect, abuse, or failures of empathic resonance from their carers. Functional brain imagery techniques including Quantitative Electroencephalogram (QEEG), and functional Magnetic Resonance Imagery (fMRI), allow us to track mental processes in ways beyond verbal reportage and introspection. This independent perspective is useful for developing new psychodynamic hypotheses, testing current ones, providing diagnostic markers, and monitoring treatment progress. Jung, with the Word Association Test, grasped these principles 100 years ago. Brain imaging techniques have contributed to powerful recent advances in our understanding of neurodevelopmental processes in the first three years of life. If adequate nurturance is compromised, a range of difficulties may emerge. This has important implications for how we understand and treat our psychotherapy clients. The paper provides an overview of functional brain imaging and advances in developmental neuropsychology, and looks at applications of some of these findings (including neurofeedback) in the Jungian psychotherapy domain. © 2017, The Society of Analytical Psychology.

3D shape recovery of smooth surfaces: dropping the fixed-viewpoint assumption.

PubMed

Moses, Yael; Shimshoni, Ilan

2009-07-01

We present a new method for recovering the 3D shape of a featureless smooth surface from three or more calibrated images illuminated by different light sources (three of them are independent). This method is unique in its ability to handle images taken from unconstrained perspective viewpoints and unconstrained illumination directions. The correspondence between such images is hard to compute and no other known method can handle this problem locally from a small number of images. Our method combines geometric and photometric information in order to recover dense correspondence between the images and accurately computes the 3D shape. Only a single pass starting at one point and local computation are used. This is in contrast to methods that use the occluding contours recovered from many images to initialize and constrain an optimization process. The output of our method can be used to initialize such processes. In the special case of fixed viewpoint, the proposed method becomes a new perspective photometric stereo algorithm. Nevertheless, the introduction of the multiview setup, self-occlusions, and regions close to the occluding boundaries are better handled, and the method is more robust to noise than photometric stereo. Experimental results are presented for simulated and real images.

PERSPECTIVE VIEW OF THE C. 1930 WAREHOUSE (CURRENT USE: RESTAURANT/OFFICES) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PERSPECTIVE VIEW OF THE C. 1930 WAREHOUSE (CURRENT USE: RESTAURANT/OFFICES) LOCATED AT 114 MADISON AVENUE, VIEW LOOKING SOUTHWEST FROM THE CORNER OF FIRST STREET AND MADISON AVENUE. - Corvallis Downtown Historic District, Bounded by First & Sixth Streets, Van Buren & Western Avenues, Corvallis, Benton County, OR

Current Issues and Perspectives in Group Work. A Counseling Monograph.

ERIC Educational Resources Information Center

Roland, Catherine B., Ed.; Conneely, Rebecca J., Ed.

Group counseling presents counselors with an increasing complexity of issues. This collection of papers addresses a range of current issues and perspectives for group counselors. The first article examines self disclosure, particularly the effects of counselor self-disclosure on the therapeutic relationship in group counseling. Clinical…

Alumni Perspectives Survey. 2014 Survey Report

ERIC Educational Resources Information Center

Schoenfeld, Gregg

2014-01-01

Alumni are a powerful force in building a business school's brand. They recommend programs to prospective students, they connect current students to job opportunities, and they contribute significantly to building a school's legacy. The findings in the 2014 Alumni Perspectives Survey Report provide a current snapshot of nearly 21,000 business…

The future orientation of constructive memory: an evolutionary perspective on therapeutic hypnosis and brief psychotherapy.

PubMed

Rossi, Ernest; Erickson-Klein, Roxanna; Rossi, Kathryn

2008-04-01

We explore a new distinction between the future, prospective memory system being investigated in current neuroscience and the past, retrospective memory system, which was the original theoretical foundation of therapeutic hypnosis, classical psychoanalysis, and psychotherapy. We then generalize a current evolutionary theory of sleep and dreaming, which focuses on the future, prospective memory system, to conceptualize a new evolutionary perspective on therapeutic hypnosis and brief psychotherapy. The implication of current neuroscience research is that activity-dependent gene expression and brain plasticity are the psychobiological basis of adaptive behavior, consciousness, and creativity in everyday life as well as psychotherapy. We summarize a case illustrating how this evolutionary perspective can be used to quickly resolve problems with past obstructive procrastination in school to facilitate current and future academic success.

Graphic Somatography: Life Writing, Comics, and the Ethics of Care.

PubMed

DeFalco, Amelia

2016-09-01

This essay considers the ways in which graphic caregiving memoirs complicate the idealizing tendencies of ethics of care philosophy. The medium's "capacious" layering of words, images, temporalities, and perspectives produces "productive tensions. . . The words and images entwine, but never synthesize" (Chute 2010, 5). In graphic memoirs about care, this "capaciousness" allows for quick oscillation between the rewards and struggles of care work, representing ambiguous, even ambivalent attitudes toward care. Graphic memoirs effectively represent multiple perspectives without synthesis, part of a structural and thematic ambivalence that provides a provocative counterpart to the abstract idealism of ethics of care philosophy.

Historical aspects of Pott's disease (spinal tuberculosis) management.

PubMed

Tuli, Surendar M

2013-06-01

Spinal tuberculosis has existed in human beings since the ascent of man on earth. Historically, the management has progressed from regional orthodox therapies to the current, more effective, drugs. Historical perspectives regarding the management have been collated by going through the important publications during the past 6 decades. For convenience, the manuscript has been organized as "orthodox traditional" treatment, early "chemotherapy period", "post chemotherapy treatment", "middle-path" philosophy, and the current treatment with availability of modern imaging facilities. Broad conclusions based upon the published data and personal observations (1959-2011) are summarized as follows: If diagnosis is made at predestructive stage and the patient is treated by standard drugs, the infection would heal in about 95 % patients without significant deformities and complications. Neural complications are still encountered in general hospital outpatients. Diagnosis and treatment at early stages would resolve the neurology without operation in about 40 % of cases. Nearly 60 % of patients would require to be operatively decompressed without jeopardizing mechanical stability. However, despite current treatment approximately 8 % of tuberculous paraplegics do not recover functionally. Immunocompromised state and multidrug resistance to standard drugs (8 to 10 %) are the current (and future) challenges to the doctors and the society.

Evaluation of experimental UAV video change detection

NASA Astrophysics Data System (ADS)

Bartelsen, J.; Saur, G.; Teutsch, C.

2016-10-01

During the last ten years, the availability of images acquired from unmanned aerial vehicles (UAVs) has been continuously increasing due to the improvements and economic success of flight and sensor systems. From our point of view, reliable and automatic image-based change detection may contribute to overcoming several challenging problems in military reconnaissance, civil security, and disaster management. Changes within a scene can be caused by functional activities, i.e., footprints or skid marks, excavations, or humidity penetration; these might be recognizable in aerial images, but are almost overlooked when change detection is executed manually. With respect to the circumstances, these kinds of changes may be an indication of sabotage, terroristic activity, or threatening natural disasters. Although image-based change detection is possible from both ground and aerial perspectives, in this paper we primarily address the latter. We have applied an extended approach to change detection as described by Saur and Kruger,1 and Saur et al.2 and have built upon the ideas of Saur and Bartelsen.3 The commercial simulation environment Virtual Battle Space 3 (VBS3) is used to simulate aerial "before" and "after" image acquisition concerning flight path, weather conditions and objects within the scene and to obtain synthetic videos. Video frames, which depict the same part of the scene, including "before" and "after" changes and not necessarily from the same perspective, are registered pixel-wise against each other by a photogrammetric concept, which is based on a homography. The pixel-wise registration is used to apply an automatic difference analysis, which, to a limited extent, is able to suppress typical errors caused by imprecise frame registration, sensor noise, vegetation and especially parallax effects. The primary concern of this paper is to seriously evaluate the possibilities and limitations of our current approach for image-based change detection with respect to the flight path, viewpoint change and parametrization. Hence, based on synthetic "before" and "after" videos of a simulated scene, we estimated the precision and recall of automatically detected changes. In addition and based on our approach, we illustrate the results showing the change detection in short, but real video sequences. Future work will improve the photogrammetric approach for frame registration, and extensive real video material, capable of change detection, will be acquired.

EMFs: cutting through the controversy.

PubMed Central

Wartenberg, D

1996-01-01

SOME SCIENTISTS ALLEGE that exposure to electric and magnetic fields generated by electric power delivery systems is responsible for certain cancers (particularly among children), reproductive dysfunction, birth defects, neurological disorders, and Alzheimer's disease. Some activist groups believe the hazard to be so great that they are calling for closure of schools and other public facilities near power lines and restructuring of the entire electric power delivery system. Some utilities, with equally strong beliefs, claim that there is no proof of risk. They argue that the science is sufficient to confirm the alleged associations and that no action is warranted. This article provides a broad overview of the current scientific data on the association between magnetic fields and disease, providing summary risk estimates and highlighting the uncertainties in the data. Building on this information, three complementary policy perspectives are presented. From a fiscally conservative perspective, the cost of mitigation already instituted far exceeds the health protection offered and mitigation of other environmental risks is more important. From a cost-benefit view, only limited, low-cost mitigation should be considered. These measures, however, would substantially reduce many exposures. From an aggressive exposure reduction perspective, much can be done to reduce exposure by personal and societal actions. If the suggested association is validated, substantially reducing magnetic field exposure could lower health risks. Images p205-a p207-a PMID:8643811

Digital image transformation and rectification of spacecraft and radar images

NASA Technical Reports Server (NTRS)

Wu, S. S. C.

1985-01-01

The application of digital processing techniques to spacecraft television pictures and radar images is discussed. The use of digital rectification to produce contour maps from spacecraft pictures is described; images with azimuth and elevation angles are converted into point-perspective frame pictures. The digital correction of the slant angle of radar images to ground scale is examined. The development of orthophoto and stereoscopic shaded relief maps from digital terrain and digital image data is analyzed. Digital image transformations and rectifications are utilized on Viking Orbiter and Lander pictures of Mars.

Social Cognitive Perspectives on the Development of Body Image in Adult Women

ERIC Educational Resources Information Center

Petersen, Kristin Lee

2017-01-01

The purpose of this study was to explore women's perceptions of the sources of information that led to the development of their body image. The problem this study addressed was women receive messages that contribute to negative body image throughout their lifetimes. When these messages are processed passively, especially when cultivated over time,…

Remote Sensing: Analyzing Satellite Images to Create Higher Order Thinking Skills.

ERIC Educational Resources Information Center

Marks, Steven K.; And Others

1996-01-01

Presents a unit that uses remote-sensing images from satellites and other spacecraft to provide new perspectives of the earth and generate greater global awareness. Relates the levels of Bloom's hierarchy to different aspects of the remote sensing unit to confirm that the concepts and principles of remote sensing and related images belong in…

IJ-OpenCV: Combining ImageJ and OpenCV for processing images in biomedicine.

PubMed

Domínguez, César; Heras, Jónathan; Pascual, Vico

2017-05-01

The effective processing of biomedical images usually requires the interoperability of diverse software tools that have different aims but are complementary. The goal of this work is to develop a bridge to connect two of those tools: ImageJ, a program for image analysis in life sciences, and OpenCV, a computer vision and machine learning library. Based on a thorough analysis of ImageJ and OpenCV, we detected the features of these systems that could be enhanced, and developed a library to combine both tools, taking advantage of the strengths of each system. The library was implemented on top of the SciJava converter framework. We also provide a methodology to use this library. We have developed the publicly available library IJ-OpenCV that can be employed to create applications combining features from both ImageJ and OpenCV. From the perspective of ImageJ developers, they can use IJ-OpenCV to easily create plugins that use any functionality provided by the OpenCV library and explore different alternatives. From the perspective of OpenCV developers, this library provides a link to the ImageJ graphical user interface and all its features to handle regions of interest. The IJ-OpenCV library bridges the gap between ImageJ and OpenCV, allowing the connection and the cooperation of these two systems. Copyright © 2017 Elsevier Ltd. All rights reserved.

Software Toolbox for Low-Frequency Conductivity and Current Density Imaging Using MRI.

PubMed

Sajib, Saurav Z K; Katoch, Nitish; Kim, Hyung Joong; Kwon, Oh In; Woo, Eung Je

2017-11-01

Low-frequency conductivity and current density imaging using MRI includes magnetic resonance electrical impedance tomography (MREIT), diffusion tensor MREIT (DT-MREIT), conductivity tensor imaging (CTI), and magnetic resonance current density imaging (MRCDI). MRCDI and MREIT provide current density and isotropic conductivity images, respectively, using current-injection phase MRI techniques. DT-MREIT produces anisotropic conductivity tensor images by incorporating diffusion weighted MRI into MREIT. These current-injection techniques are finding clinical applications in diagnostic imaging and also in transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and electroporation where treatment currents can function as imaging currents. To avoid adverse effects of nerve and muscle stimulations due to injected currents, conductivity tensor imaging (CTI) utilizes B1 mapping and multi-b diffusion weighted MRI to produce low-frequency anisotropic conductivity tensor images without injecting current. This paper describes numerical implementations of several key mathematical functions for conductivity and current density image reconstructions in MRCDI, MREIT, DT-MREIT, and CTI. To facilitate experimental studies of clinical applications, we developed a software toolbox for these low-frequency conductivity and current density imaging methods. This MR-based conductivity imaging (MRCI) toolbox includes 11 toolbox functions which can be used in the MATLAB environment. The MRCI toolbox is available at http://iirc.khu.ac.kr/software.html . Its functions were tested by using several experimental datasets, which are provided together with the toolbox. Users of the toolbox can focus on experimental designs and interpretations of reconstructed images instead of developing their own image reconstruction softwares. We expect more toolbox functions to be added from future research outcomes. Low-frequency conductivity and current density imaging using MRI includes magnetic resonance electrical impedance tomography (MREIT), diffusion tensor MREIT (DT-MREIT), conductivity tensor imaging (CTI), and magnetic resonance current density imaging (MRCDI). MRCDI and MREIT provide current density and isotropic conductivity images, respectively, using current-injection phase MRI techniques. DT-MREIT produces anisotropic conductivity tensor images by incorporating diffusion weighted MRI into MREIT. These current-injection techniques are finding clinical applications in diagnostic imaging and also in transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and electroporation where treatment currents can function as imaging currents. To avoid adverse effects of nerve and muscle stimulations due to injected currents, conductivity tensor imaging (CTI) utilizes B1 mapping and multi-b diffusion weighted MRI to produce low-frequency anisotropic conductivity tensor images without injecting current. This paper describes numerical implementations of several key mathematical functions for conductivity and current density image reconstructions in MRCDI, MREIT, DT-MREIT, and CTI. To facilitate experimental studies of clinical applications, we developed a software toolbox for these low-frequency conductivity and current density imaging methods. This MR-based conductivity imaging (MRCI) toolbox includes 11 toolbox functions which can be used in the MATLAB environment. The MRCI toolbox is available at http://iirc.khu.ac.kr/software.html . Its functions were tested by using several experimental datasets, which are provided together with the toolbox. Users of the toolbox can focus on experimental designs and interpretations of reconstructed images instead of developing their own image reconstruction softwares. We expect more toolbox functions to be added from future research outcomes.

Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity

EPA Science Inventory

Safety-related problems continue to be one of the major reasons of attrition in drug development. Non-testing approaches to predict toxicity could form part of the solution. This review provides a perspective of current status of non-testing approaches available for the predictio...

A Holistic Theoretical Approach to Intellectual Disability: Going beyond the Four Current Perspectives

ERIC Educational Resources Information Center

Schalock, Robert L.; Luckasson, Ruth; Tassé, Marc J.; Verdugo, Miguel Angel

2018-01-01

This article describes a holistic theoretical framework that can be used to explain intellectual disability (ID) and organize relevant information into a usable roadmap to guide understanding and application. Developing the framework involved analyzing the four current perspectives on ID and synthesizing this information into a holistic…

Debunking the Pocahontas Paradox: The Need for a Humanistic Perspective.

ERIC Educational Resources Information Center

Portman, Tarrell Awe Agahe; Herring, Roger D.

2001-01-01

Historical and contemporary stereotypes of Native American Indian women have resulted in inaccurate and insensitive images. Mass media, movies, and printed materials continue to portray Native American Indian women as either princesses or savages. The purpose of this article is to provide a more humanistic perspective of this population. (Contains…

Stereograms

ERIC Educational Resources Information Center

Kuchemann, Dietmar

2007-01-01

Perspective is a rich area for mathematical work, and one that should be accessible to many students, since it is based on the everyday experience of viewing the 3D world directly and through familiar 2D representations (drawings, photographs, images on a television or cinema screen, etc). A nice feature of perspective tasks is that they can be…

Revisiting Metaphors for Education: A Student's Perspective

ERIC Educational Resources Information Center

Nikitina, Larisa; Furuoka, Fumitaka

2011-01-01

This study examines metaphors about learning produced by a group of eighteen students at a big public university in Malaysia. The learner perspective is placed within a wider discourse on education in order to explore whether the images employed by the learners to describe their learning reflect the dominant conception of education as…

A Multimodal Perspective on Textuality and Contexts

ERIC Educational Resources Information Center

Jewitt, Carey

2007-01-01

Textuality is often thought of in linguistic terms; for instance, the talk and writing that circulate in the classroom. In this paper I take a multimodal perspective on textuality and context. I draw on illustrative examples from school Science and English to examine how image, colour, gesture, gaze, posture and movement--as well as writing and…

Mirror, Mirror on the Wall: Reflections on Speech-Language Pathologists' Image as Advocates, Activists, and Aides

ERIC Educational Resources Information Center

Donaldson, Amy L.; Chabon, Shelly; Lee-Wilkerson, Dorian; Kapantzoglou, Maria

2017-01-01

Traditionally speech-language pathology, along with other educational and rehabilitation-based professions, has approached disability from a deficits-based or medical-model perspective with an aim toward normalizing or ameliorating a child's atypical behaviors or performance. However, an alternative perspective rooted in a social model of…

Workshop for Open Source Universal Picture Archiving and Communication Systems (PACS)

DTIC Science & Technology

2006-12-01

Gap! Michael J. Ackerman, PhD NLM/NIH 2:00pm Triple Helix Model Conrad Clyburn TATRC 2:30pm Perspectives from FDA Alford Taylor CDRH ...Medical Robotics, BRSS, STAT- Care and Retinal Imaging) 57 An FDA Perspective Alford Taylor, Jr., CDRH /FDA Issues • CDRH mission is to protect

Histomorphometric, fractal and lacunarity comparative analysis of sheep (Ovis aries), goat (Capra hircus) and roe deer (Capreolus capreolus) compact bone samples.

PubMed

Gudea, A I; Stefan, A C

2013-08-01

Quantitative and qualitative studies dealing with histomorphometry of the bone tissue play a new role in modern legal medicine/forensic medicine and archaeozoology nowadays. This study deals with the differences found in case of humerus and metapodial bones of recent sheep (Ovis aries), goat (Capra hircus) and roedeer (Capreolus capreolus) specimens, both from a qualitative point of view, but mainly from a quantitative perspective. A novel perspective given by the fractal analysis performed on the digital histological images is approached. This study shows that the qualitative assessment may not be a reliable one due to the close resemblance of the structures. From the quantitative perspective (several measurements performed on osteonal units and statistical processing of data),some of the elements measured show significant differences among 3 species(the primary osteonal diameter, etc.). The fractal analysis and the lacunarity of the images show a great deal of potential, proving that this type of analysis can be of great help in the separation of the material from this perspective.

Perspective View with Landsat Overlay, Mount Shasta, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

The volcanic nature of Mount Shasta is clearly evident in this computer-generated perspective viewed from the northwest. At over 4,300 meters (14,000 feet), Mount Shasta is California's tallest volcano and part of the Cascade chain of volcanoes extending south from Washington. The twin summits of Shasta and Shastina tower over a lava flow on the flank of the volcano. Cutting across the lava flow is the bright line of a railroad. The bright area at the right edge is the town of Weed.

This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced false-color Landsat 5 satellite image. Colors are from Landsat bands 3, 2, and 1 as red, green and blue, respectively. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

The Landsat Thematic Mapper image used here came from an online mosaic of Landsat images for the continental United States (http://mapus.jpl.nasa.gov), a part of NASA's Digital Earth effort.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

Size: scale varies in this perspective image Location: 41.4 degrees North latitude, 122.3 degrees West longitude Orientation: looking southeast Image Data: Landsat Bands 3, 2, 1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet) Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Titanic exploration with GIS

USGS Publications Warehouse

Kerski, J.J.

2004-01-01

To help teachers and students investigate one of the world's most famous historical events using the geographic perspective and GIS tools and methods, the U.S. Geological Survey (USGS) created a set of educational lessons based on the RMS Titanic's April 1912 sailing. With these lessons, student researchers can learn about latitude and longitude, map projections, ocean currents, databases, maps, and images through the analysis of the route, warnings, sinking, rescue, and eventual discovery of the submerged ocean liner in 1985. They can also consider the human and physical aspects of the maiden voyage in the North Atlantic Ocean at a variety of scales, from global to regional to local. Likewise, their investigations can reveal how the sinking of the Titanic affected future shipping routes.

Beauty and the brain: culture, history and individual differences in aesthetic appreciation.

PubMed

Jacobsen, Thomas

2010-02-01

Human aesthetic processing entails the sensation-based evaluation of an entity with respect to concepts like beauty, harmony or well-formedness. Aesthetic appreciation has many determinants ranging from evolutionary, anatomical or physiological constraints to influences of culture, history and individual differences. There are a vast number of dynamically configured neural networks underlying these multifaceted processes of aesthetic appreciation. In the current challenge of successfully bridging art and science, aesthetics and neuroanatomy, the neuro-cognitive psychology of aesthetics can approach this complex topic using a framework that postulates several perspectives, which are not mutually exclusive. In this empirical approach, objective physiological data from event-related brain potentials and functional magnetic resonance imaging are combined with subjective, individual self-reports.

Beauty and the brain: culture, history and individual differences in aesthetic appreciation

PubMed Central

Jacobsen, Thomas

2010-01-01

Human aesthetic processing entails the sensation-based evaluation of an entity with respect to concepts like beauty, harmony or well-formedness. Aesthetic appreciation has many determinants ranging from evolutionary, anatomical or physiological constraints to influences of culture, history and individual differences. There are a vast number of dynamically configured neural networks underlying these multifaceted processes of aesthetic appreciation. In the current challenge of successfully bridging art and science, aesthetics and neuroanatomy, the neuro-cognitive psychology of aesthetics can approach this complex topic using a framework that postulates several perspectives, which are not mutually exclusive. In this empirical approach, objective physiological data from event-related brain potentials and functional magnetic resonance imaging are combined with subjective, individual self-reports. PMID:19929909

Inspection of aging aircraft: A manufacturer's perspective

NASA Technical Reports Server (NTRS)

Hagemaier, Donald J.

1992-01-01

Douglas, in conjunction with operators and regulators, has established interrelated programs to identify and address issues regarding inspection of aging aircraft. These inspection programs consist of the following: Supplemental Inspection Documents; Corrosion Prevention and Control Documents; Repair Assessment Documents; and Service Bulletin Compliance Documents. In addition, airframe manufacturers perform extended airframe fatigue tests to deal with potential problems before they can develop in the fleet. Lastly, nondestructive inspection (NDI) plays a role in all these programs through the detection of cracks, corrosion, and disbonds. However, improved and more cost effective NDI methods are needed. Some methods such as magneto-optic imaging, electronic shearography, Diffractor-Sight, and multi-parameter eddy current testing appear viable for near-term improvements in NDI of aging aircraft.

Retinal image registration for eye movement estimation.

PubMed

Kolar, Radim; Tornow, Ralf P; Odstrcilik, Jan

2015-01-01

This paper describes a novel methodology for eye fixation measurement using a unique videoophthalmoscope setup and advanced image registration approach. The representation of the eye movements via Poincare plot is also introduced. The properties, limitations and perspective of this methodology are finally discussed.

Gradient Space under Orthography and Perspective

DTIC Science & Technology

1982-05-24

surfaceorientation to image geometry [8, 9, 10, 13, 15]. The descriptions of important gradient space properties, however, have been scattered throughout...Kanade, T. A Theory of Origami World. Artificial Intelligence 13:279-311, 1980. *[8] Kanade, T. and Kender, J. Mapping Image Properies into Shape

A novel role for visual perspective cues in the neural computation of depth.

PubMed

Kim, HyungGoo R; Angelaki, Dora E; DeAngelis, Gregory C

2015-01-01

As we explore a scene, our eye movements add global patterns of motion to the retinal image, complicating visual motion produced by self-motion or moving objects. Conventionally, it has been assumed that extraretinal signals, such as efference copy of smooth pursuit commands, are required to compensate for the visual consequences of eye rotations. We consider an alternative possibility: namely, that the visual system can infer eye rotations from global patterns of image motion. We visually simulated combinations of eye translation and rotation, including perspective distortions that change dynamically over time. We found that incorporating these 'dynamic perspective' cues allowed the visual system to generate selectivity for depth sign from motion parallax in macaque cortical area MT, a computation that was previously thought to require extraretinal signals regarding eye velocity. Our findings suggest neural mechanisms that analyze global patterns of visual motion to perform computations that require knowledge of eye rotations.

Advanced Interactive Display Formats for Terminal Area Traffic Control

NASA Technical Reports Server (NTRS)

Grunwald, Arthur J.; Shaviv, G. E.

1999-01-01

This research project deals with an on-line dynamic method for automated viewing parameter management in perspective displays. Perspective images are optimized such that a human observer will perceive relevant spatial geometrical features with minimal errors. In order to compute the errors at which observers reconstruct spatial features from perspective images, a visual spatial-perception model was formulated. The model was employed as the basis of an optimization scheme aimed at seeking the optimal projection parameter setting. These ideas are implemented in the context of an air traffic control (ATC) application. A concept, referred to as an active display system, was developed. This system uses heuristic rules to identify relevant geometrical features of the three-dimensional air traffic situation. Agile, on-line optimization was achieved by a specially developed and custom-tailored genetic algorithm (GA), which was to deal with the multi-modal characteristics of the objective function and exploit its time-evolving nature.

Perspective: The Alzheimer's Disease Neuroimaging Initiative and the role and contributions of the Private Partner Scientific Board (PPSB).

PubMed

Liu, Enchi; Luthman, Johan; Cedarbaum, Jesse M; Schmidt, Mark E; Cole, Patricia E; Hendrix, James; Carrillo, Maria C; Jones-Davis, Dorothy; Tarver, Erika; Novak, Gerald; De Santi, Susan; Soares, Holly D; Potter, William Z; Siemers, Eric; Schwarz, Adam J

2015-07-01

The Alzheimer's Disease Neuroimaging Initiative (ADNI) Private Partner Scientific Board (PPSB) is comprised of representatives of private, for-profit entities (including pharmaceutical, biotechnology, diagnostics, imaging companies, and imaging contract research organizations), and nonprofit organizations that provide financial and scientific support to ADNI through the Foundation for the National Institutes of Health. The PPSB serves as an independent, open, and precompetitive forum in which all private sector and not-for-profit partners in ADNI can collaborate, share information, and offer scientific and private-sector perspectives and expertise on issues relating to the ADNI project. In this article, we review and highlight the role, activities, and contributions of the PPSB within the ADNI project, and provide a perspective on remaining unmet needs and future directions. Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Robust vehicle detection in different weather conditions: Using MIPM

PubMed Central

Menéndez, José Manuel; Jiménez, David

2018-01-01

Intelligent Transportation Systems (ITS) allow us to have high quality traffic information to reduce the risk of potentially critical situations. Conventional image-based traffic detection methods have difficulties acquiring good images due to perspective and background noise, poor lighting and weather conditions. In this paper, we propose a new method to accurately segment and track vehicles. After removing perspective using Modified Inverse Perspective Mapping (MIPM), Hough transform is applied to extract road lines and lanes. Then, Gaussian Mixture Models (GMM) are used to segment moving objects and to tackle car shadow effects, we apply a chromacity-based strategy. Finally, performance is evaluated through three different video benchmarks: own recorded videos in Madrid and Tehran (with different weather conditions at urban and interurban areas); and two well-known public datasets (KITTI and DETRAC). Our results indicate that the proposed algorithms are robust, and more accurate compared to others, especially when facing occlusions, lighting variations and weather conditions. PMID:29513664

Toward translational incremental similarity-based reasoning in breast cancer grading

NASA Astrophysics Data System (ADS)

Tutac, Adina E.; Racoceanu, Daniel; Leow, Wee-Keng; Müller, Henning; Putti, Thomas; Cretu, Vladimir

2009-02-01

One of the fundamental issues in bridging the gap between the proliferation of Content-Based Image Retrieval (CBIR) systems in the scientific literature and the deficiency of their usage in medical community is based on the characteristic of CBIR to access information by images or/and text only. Yet, the way physicians are reasoning about patients leads intuitively to a case representation. Hence, a proper solution to overcome this gap is to consider a CBIR approach inspired by Case-Based Reasoning (CBR), which naturally introduces medical knowledge structured by cases. Moreover, in a CBR system, the knowledge is incrementally added and learned. The purpose of this study is to initiate a translational solution from CBIR algorithms to clinical practice, using a CBIR/CBR hybrid approach. Therefore, we advance the idea of a translational incremental similarity-based reasoning (TISBR), using combined CBIR and CBR characteristics: incremental learning of medical knowledge, medical case-based structure of the knowledge (CBR), image usage to retrieve similar cases (CBIR), similarity concept (central for both paradigms). For this purpose, three major axes are explored: the indexing, the cases retrieval and the search refinement, applied to Breast Cancer Grading (BCG), a powerful breast cancer prognosis exam. The effectiveness of this strategy is currently evaluated over cases provided by the Pathology Department of Singapore National University Hospital, for the indexing. With its current accuracy, TISBR launches interesting perspectives for complex reasoning in future medical research, opening the way to a better knowledge traceability and a better acceptance rate of computer-aided diagnosis assistance among practitioners.

Mercury-Cadmium-Telluride Focal Plane Array Performance Under Non-Standard Operating Conditions

NASA Technical Reports Server (NTRS)

Richardson, Brandon S.; Eastwood, Michael L.; Bruce, Carl F.; Green, Robert O.; Coles, J. B.

2011-01-01

This paper highlights a new technique that allows the Teledyne Scientific & Imaging LLC TCM6604A Mercury-Cadmium-Telluride (MCT) Focal Plane Array (FPA) to operate at room temperature. The Teledyne MCT FPA has been a standard in Imaging Spectroscopy since its creation in the 1980's. This FPA has been used in applications ranging from space instruments such as CRISM, M3 and ARTEMIS to airborne instruments such as MaRS and the Next Generation AVIRIS Instruments1. Precise focal plane alignment is always a challenge for such instruments. The current FPA alignment process results in multiple cold cycles requiring week-long durations, thereby increasing the risk and cost of a project. These alignment cycles are necessary because optimal alignment is approached incrementally and can only be measured with the FPA and Optics at standard operating conditions, requiring a cold instrument. Instruments using this FPA are normally cooled to temperatures below 150K for the MCT FPA to properly function. When the FPA is run at higher temperatures the dark current increases saturating the output. This paper covers the prospect of warm MCT FPA operation from a theoretical and experimental perspective. We discuss the empirical models and physical laws that govern MCT material properties and predict the optimal settings that will result in the best MCT PA performance at 300K. Theoretical results are then calculated for the proposed settings. We finally present the images and data obtained using the actual system with the warm MCT FPA settings. The paper concludes by emphasizing the strong positive correlation between the measured values and the theoretical results.

The Focusing Optics X-ray Solar Imager (FOXSI) SMEX Mission

NASA Astrophysics Data System (ADS)

Christe, S.; Shih, A. Y.; Krucker, S.; Glesener, L.; Saint-Hilaire, P.; Caspi, A.; Allred, J. C.; Battaglia, M.; Chen, B.; Drake, J. F.; Gary, D. E.; Goetz, K.; Gburek, S.; Grefenstette, B.; Hannah, I. G.; Holman, G.; Hudson, H. S.; Inglis, A. R.; Ireland, J.; Ishikawa, S. N.; Klimchuk, J. A.; Kontar, E.; Kowalski, A. F.; Massone, A. M.; Piana, M.; Ramsey, B.; Schwartz, R.; Steslicki, M.; Turin, P.; Ryan, D.; Warmuth, A.; Veronig, A.; Vilmer, N.; White, S. M.; Woods, T. N.

2017-12-01

We present FOXSI (Focusing Optics X-ray Solar Imager), a Small Explorer (SMEX) Heliophysics mission that is currently undergoing a Phase A concept study. FOXSI will provide a revolutionary new perspective on energy release and particle acceleration on the Sun. FOXSI is a direct imaging X-ray spectrometer with higher dynamic range and better than 10x the sensitivity of previous instruments. Flown on a 3-axis-stabilized spacecraft in low-Earth orbit, FOXSI uses high-angular-resolution grazing-incidence focusing optics combined with state-of-the-art pixelated solid-state detectors to provide direct imaging of solar hard X-rays for the first time. FOXSI is composed of a pair of x-ray telescopes with a 14-meter focal length enabled by a deployable boom. Making use of a filter-wheel and high-rate-capable solid-state detectors, FOXSI will be able to observe the largest flares without saturation while still maintaining the sensitivity to detect x-ray emission from weak flares, escaping electrons, and hot active regions. This mission concept is made possible by past experience with similar instruments on two FOXSI sounding rocket flights, in 2012 and 2014, and on the HEROES balloon flight in 2013. FOXSI's hard X-ray imager has a field of view of 9 arcminutes and an angular resolution of better than 8 arcsec; it will cover the energy range from 3 up to 50-70 keV with a spectral resolution of better than 1 keV; and it will have sub-second temporal resolution.

Crowdsourcing Precision Cerebrovascular Health: Imaging and Cloud Seeding A Million Brains Initiative™.

PubMed

Liebeskind, David S

2016-01-01

Crowdsourcing, an unorthodox approach in medicine, creates an unusual paradigm to study precision cerebrovascular health, eliminating the relative isolation and non-standardized nature of current imaging data infrastructure, while shifting emphasis to the astounding capacity of big data in the cloud. This perspective envisions the use of imaging data of the brain and vessels to orient and seed A Million Brains Initiative™ that may leapfrog incremental advances in stroke and rapidly provide useful data to the sizable population around the globe prone to the devastating effects of stroke and vascular substrates of dementia. Despite such variability in the type of data available and other limitations, the data hierarchy logically starts with imaging and can be enriched with almost endless types and amounts of other clinical and biological data. Crowdsourcing allows an individual to contribute to aggregated data on a population, while preserving their right to specific information about their own brain health. The cloud now offers endless storage, computing prowess, and neuroimaging applications for postprocessing that is searchable and scalable. Collective expertise is a windfall of the crowd in the cloud and particularly valuable in an area such as cerebrovascular health. The rise of precision medicine, rapidly evolving technological capabilities of cloud computing and the global imperative to limit the public health impact of cerebrovascular disease converge in the imaging of A Million Brains Initiative™. Crowdsourcing secure data on brain health may provide ultimate generalizability, enable focused analyses, facilitate clinical practice, and accelerate research efforts.

Atomically Thin Graphene Windows That Enable High Contrast Electron Microscopy without a Specimen Vacuum Chamber.

PubMed

Han, Yimo; Nguyen, Kayla X; Ogawa, Yui; Park, Jiwoong; Muller, David A

2016-12-14

Scanning electron microscopes (SEMs) require a high vacuum environment to generate and shape an electron beam for imaging; however, the vacuum conditions greatly limit the nature of specimens that can be examined. From a purely scattering physics perspective, it is not necessary to place the specimen inside the vacuum chamber-the mean free paths (MFPs) for electron scattering in air at typical SEM beam voltages are 50-100 μm. This is the idea behind the airSEM, which removes the specimen vacuum chamber from the SEM and places the sample in air. The thickness of the gas layer is less than a MFP from an electron-transparent window to preserve the shape and resolution of the incident beam, resulting in comparable imaging quality to an all-vacuum SEM. Present silicon nitride windows scatter far more strongly than the air gap and are currently the contrast and resolution limiting factor in the airSEM. Graphene windows have been used previously to wrap or seal samples in vacuum for imaging. Here we demonstrate the use of a robust bilayer graphene window for sealing the electron optics from the room environment, providing an electron transparent window with only a 2% drop in contrast. There is a 5-fold-increase in signal/noise ratio for imaging compared to multi-MFP-thick silicon nitride windows, enabling high contrast in backscattered, transmission, and surface imaging modes for the new airSEM geometry.

DNA nanomaterials for preclinical imaging and drug delivery.

PubMed

Jiang, Dawei; England, Christopher G; Cai, Weibo

2016-10-10

Besides being the carrier of genetic information, DNA is also an excellent biological organizer to establish well-designed nanostructures in the fields of material engineering, nanotechnology, and biomedicine. DNA-based materials represent a diverse nanoscale system primarily due to their predictable base pairing and highly regulated conformations, which greatly facilitate the construction of DNA nanostructures with distinct shapes and sizes. Integrating the emerging advancements in bioconjugation techniques, DNA nanostructures can be readily functionalized with high precision for many purposes ranging from biosensors to imaging to drug delivery. Recent progress in the field of DNA nanotechnology has exhibited collective efforts to employ DNA nanostructures as smart imaging agents or delivery platforms within living organisms. Despite significant improvements in the development of DNA nanostructures, there is limited knowledge regarding the in vivo biological fate of these intriguing nanomaterials. In this review, we summarize the current strategies for designing and purifying highly-versatile DNA nanostructures for biological applications, including molecular imaging and drug delivery. Since DNA nanostructures may elicit an immune response in vivo, we also present a short discussion of their potential toxicities in biomedical applications. Lastly, we discuss future perspectives and potential challenges that may limit the effective preclinical and clinical employment of DNA nanostructures. Due to their unique properties, we predict that DNA nanomaterials will make excellent agents for effective diagnostic imaging and drug delivery, improving patient outcome in cancer and other related diseases in the near future. Copyright © 2016 Elsevier B.V. All rights reserved.

Jupiter: A New Perspective

NASA Image and Video Library

2018-05-16

This extraordinary view of Jupiter was captured by NASA's Juno spacecraft on the outbound leg of its 12th close flyby of the gas giant planet. This new perspective of Jupiter from the south makes the Great Red Spot appear as though it is in northern territory. This view is unique to Juno and demonstrates how different our view is when we step off the Earth and experience the true nature of our three-dimensional universe. Juno took the images used to produce this color-enhanced image on April 1 between 3:04 a.m. PDT (6:04 a.m. EDT) and 3:36 a.m. PDT (6:36 a.m. EDT). At the time the images were taken, the spacecraft was between 10,768 miles (17,329 kilometers) to 42,849 miles (68,959 kilometers) from the tops of the clouds of the planet at a southern latitude spanning 34.01 to 71.43 degrees. Citizen scientists Gerald Eichstädt and Seán Doran created this image using data from the spacecraft's JunoCam imager. The view is a composite of several separate JunoCam images that were re-projected, blended, and healed. https://photojournal.jpl.nasa.gov/catalog/PIA22421

NOTE: Wobbled splatting—a fast perspective volume rendering method for simulation of x-ray images from CT

NASA Astrophysics Data System (ADS)

Birkfellner, Wolfgang; Seemann, Rudolf; Figl, Michael; Hummel, Johann; Ede, Christopher; Homolka, Peter; Yang, Xinhui; Niederer, Peter; Bergmann, Helmar

2005-05-01

3D/2D registration, the automatic assignment of a global rigid-body transformation matching the coordinate systems of patient and preoperative volume scan using projection images, is an important topic in image-guided therapy and radiation oncology. A crucial part of most 3D/2D registration algorithms is the fast computation of digitally rendered radiographs (DRRs) to be compared iteratively to radiographs or portal images. Since registration is an iterative process, fast generation of DRRs—which are perspective summed voxel renderings—is desired. In this note, we present a simple and rapid method for generation of DRRs based on splat rendering. As opposed to conventional splatting, antialiasing of the resulting images is not achieved by means of computing a discrete point spread function (a so-called footprint), but by stochastic distortion of either the voxel positions in the volume scan or by the simulation of a focal spot of the x-ray tube with non-zero diameter. Our method generates slightly blurred DRRs suitable for registration purposes at framerates of approximately 10 Hz when rendering volume images with a size of 30 MB.

Perspective View with Landsat Overlay, San Francisco Bay Area, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

The defining landmarks of San Francisco, its bay and the San Andreas Fault are clearly seen in this computer-generated perspective viewed from the south. Running from the bottom of the scene diagonally up to the left, the trough of the San Andreas Fault is occupied by Crystal Springs Reservoir and San Andreas Lake. Interstate 280 winds along the side of the fault. San Francisco International Airport is the angular feature projecting into the bay just below San Bruno Mountain, the elongated ridge cutting across the peninsula. The hills of San Francisco can be seen beyond San Bruno Mountain and beyond the city, the Golden Gate.

This 3-D perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced color Landsat 5satellite image. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11,2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

Size: scale varies in this perspective image Location: 37.5 deg. North lat., 122.3 deg. West lon. Orientation: looking north Image Data: Landsat Bands 3,2,1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet), Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Hysteroscopic simulator for training and educational purposes.

PubMed

Lim, Fabian; Brown, Ian; McColl, Ryan; Seligman, Cory; Alsaraira, Amer

2006-01-01

Hysteroscopy is an extensively popular option in evaluating and treating women with infertility. The procedure utilizes an endoscope, inserted through the vagina and cervix to examine the intra-uterine cavity via a monitor. The difficulty of hysteroscopy from the surgeon's perspective is the visual spatial perception of interpreting 3D images on a 2D monitor, and the associated psychomotor skills in overcoming the fulcrum-effect. Despite the widespread use of this procedure, current qualified hysteroscopy surgeons have not been trained the fundamentals through an organized curriculum. The emergence of virtual reality as an educational tool for this procedure, and for other endoscopic procedures, has undoubtedly raised interests. The ultimate objective is for the inclusion of virtual reality training as a mandatory component for gynecological endoscopic training. Part of this process involves the design of a simulator, encompassing the technical difficulties and complications associated with the procedure. The proposed research examines fundamental hysteroscopic factors as well as current training and accreditation norms, and proposes a hysteroscopic simulator design that is suitable for educating and training.

Fetal well-being assessment in bovine near-term gestations: Current knowledge and future perspectives arising from comparative medicine

PubMed Central

Buczinski, Sébastien M.C.; Fecteau, Gilles; Lefebvre, Réjean C.; Smith, Lawrence C.

2007-01-01

Cloning technology is associated with multiple losses throughout pregnancy and in the neonatal period. Any maternal or fetal disease can compromise pregnancy. A paucity of data are available on bovine fetal well-being in late pregnancy; development of well-being assessment methods might augment early diagnosis of abnormal pregnancy or fetal distress, allowing early intervention. This review presents the current knowledge on fetal well-being based on bovine, ovine, equine, and human studies, as well as interesting research parameters that have been studied in other species and not yet investigated in cattle. Transabdominal ultrasonography allows for diagnosis of large placentomes and hydrallantois that frequently accompany clone pregnancies. Fetal inactivity or large hyperechoic particles imaged within the fetal annexes are associated with fetal distress or death, and should be reassessed to confirm compromised pregnancy. Measurements of different fetal parameters (thoracic aorta, metacarpal or metatarsal thickness) could be reliable tools for early detection of the large offspring syndrome commonly found in cloned calves. PMID:17334032

New Advances in Nanotechnology-Based Diagnosis and Therapeutics for Breast Cancer: An Assessment of Active-Targeting Inorganic Nanoplatforms.

PubMed

Falagan-Lotsch, Priscila; Grzincic, Elissa M; Murphy, Catherine J

2017-01-18

Breast cancer is a major cause of suffering and mortality among women. Limitations in the current diagnostic methods and treatment approaches have led to new strategies to positively impact the survival rates and quality of life of breast cancer patients. Nanotechnology offers a real possibility of mitigating breast cancer mortality by early-stage cancer detection and more precise diagnosis as well as more effective treatments with minimal side effects. The current nanoplatforms approved for breast cancer therapeutics are based on passive tumor targeting using organic nanoparticles and have not provided the expected significant improvements in the clinic. In this review, we present the emerging approaches in breast cancer nanomedicine based on active targeting using versatile inorganic nanoplatforms with biomedical relevance, such as gold, silica, and iron oxide nanoparticles, as well as their efficacy in breast cancer imaging, drug and gene delivery, thermal therapy, combinational therapy, and theranostics in preclinical studies. The main challenges for clinical translation and perspectives are discussed.

A visual graphic/haptic rendering model for hysteroscopic procedures.

PubMed

Lim, Fabian; Brown, Ian; McColl, Ryan; Seligman, Cory; Alsaraira, Amer

2006-03-01

Hysteroscopy is an extensively popular option in evaluating and treating women with infertility. The procedure utilises an endoscope, inserted through the vagina and cervix to examine the intra-uterine cavity via a monitor. The difficulty of hysteroscopy from the surgeon's perspective is the visual spatial perception of interpreting 3D images on a 2D monitor, and the associated psychomotor skills in overcoming the fulcrum-effect. Despite the widespread use of this procedure, current qualified hysteroscopy surgeons have not been trained the fundamentals through an organised curriculum. The emergence of virtual reality as an educational tool for this procedure, and for other endoscopic procedures, has undoubtedly raised interests. The ultimate objective is for the inclusion of virtual reality training as a mandatory component for gynaecologic endoscopy training. Part of this process involves the design of a simulator, encompassing the technical difficulties and complications associated with the procedure. The proposed research examines fundamental hysteroscopy factors, current training and accreditation, and proposes a hysteroscopic simulator design that is suitable for educating and training.

Infrared Imaging of Boundary Layer Transition Flight Experiments

NASA Technical Reports Server (NTRS)

Berry, Scott A.; Horvath, Thomas J., Jr.; Schwartz, Richard; Ross, Martin; Anderson, Brian; Campbell, Charles H.

2008-01-01

The Hypersonic Thermodynamic Infrared Measurement (HYTHIRM) project is presently focused on near term support to the Shuttle program through the development of an infrared imaging capability of sufficient spatial and temporal resolution to augment existing on-board Orbiter instrumentation. Significant progress has been made with the identification and inventory of relevant existing optical imaging assets and the development, maturation, and validation of simulation and modeling tools for assessment and mission planning purposes, which were intended to lead to the best strategies and assets for successful acquisition of quantitative global surface temperature data on the Shuttle during entry. However, there are longer-term goals of providing global infrared imaging support to other flight projects as well. A status of HYTHIRM from the perspective of how two NASA-sponsored boundary layer transition flight experiments could benefit by infrared measurements is provided. Those two flight projects are the Hypersonic Boundary layer Transition (HyBoLT) flight experiment and the Shuttle Boundary Layer Transition Flight Experiment (BLT FE), which are both intended for reducing uncertainties associated with the extrapolation of wind tunnel derived transition correlations for flight application. Thus, the criticality of obtaining high quality flight data along with the impact it would provide to the Shuttle program damage assessment process are discussed. Two recent wind tunnel efforts that were intended as risk mitigation in terms of quantifying the transition process and resulting turbulent wedge locations are briefly reviewed. Progress is being made towards finalizing an imaging strategy in support of the Shuttle BLT FE, however there are no plans currently to image HyBoLT.

Imaging genetics of schizophrenia in the post-GWAS era.

PubMed

Arslan, Ayla

2018-01-03

Imaging genetics is a research methodology studying the effect of genetic variation on brain structure, function, behavior, and risk for psychopathology. Since the early 2000s, imaging genetics has been increasingly used in the research of schizophrenia (SZ). SZ is a severe mental disorder with no precise knowledge of its underlying neurobiology, however, new genetic and neurobiological data generate a climate for new avenues. The accumulating data of genome wide association studies (GWAS) continuously decode SZ risk genes. Global neuroimaging consortia produce collections of brain phenotypes from tens of thousands of people. In this context, imaging genetics will be strategically important both for the validation and discovery of SZ related findings. Thus, the study of GWAS supported risk variants as candidate genes to validate by neuroimaging is one trend. The study of epigenetic differences in relation to variations of brain phenotypes and the study of large scale multivariate analysis of genome wide and brain wide associations are other trends. While these studies hold a big potential for understanding the neurobiology of SZ, the problem of reproducibility appears as a major challenge, which requires standardizations in study designs and compensations of methodological limitations such as sensitivity and specificity. On the other hand, advancements of neuroimaging, optical and electron microscopy along with the use of genetically encoded fluorescent probes and robust statistical approaches will not only catalyze integrative methodologies but also will help better design the imaging genetics studies. In this invited paper, I will discuss the current perspective of imaging genetics and emerging opportunities of SZ research. Copyright © 2017 Elsevier Inc. All rights reserved.

Facets of radio-loud AGN evolution : a LOFAR surveys perspective

NASA Astrophysics Data System (ADS)

Williams, W. L.

2015-12-01

Radio observations provide a unique view of black holes in the Universe. This thesis presents low frequency radio images and uses the radio sources in those images to study the evolution of black holes and galaxies through the age of the Universe.

An Improved Text Localization Method for Natural Scene Images

NASA Astrophysics Data System (ADS)

Jiang, Mengdi; Cheng, Jianghua; Chen, Minghui; Ku, Xishu

2018-01-01

In order to extract text information effectively from natural scene image with complex background, multi-orientation perspective and multilingual languages, we present a new method based on the improved Stroke Feature Transform (SWT). Firstly, The Maximally Stable Extremal Region (MSER) method is used to detect text candidate regions. Secondly, the SWT algorithm is used in the candidate regions, which can improve the edge detection compared with tradition SWT method. Finally, the Frequency-tuned (FT) visual saliency is introduced to remove non-text candidate regions. The experiment results show that, the method can achieve good robustness for complex background with multi-orientation perspective, various characters and font sizes.

Construction of a Conceptualization of Personal Knowledge within a Knowledge Management Perspective Using Grounded Theory Methodology

ERIC Educational Resources Information Center

Straw, Eric M.

2013-01-01

The current research used grounded theory methodology (GTM) to construct a conceptualization of personal knowledge within a knowledge management (KM) perspective. The need for the current research was based on the use of just two categories of knowledge, explicit and tacit, within KM literature to explain diverse characteristics of personal…

Kinematic Measurement of Knee Prosthesis from Single-Plane Projection Images

NASA Astrophysics Data System (ADS)

Hirokawa, Shunji; Ariyoshi, Shogo; Takahashi, Kenji; Maruyama, Koichi

In this paper, the measurement of 3D motion from 2D perspective projections of knee prosthesis is described. The technique reported by Banks and Hodge was further developed in this study. The estimation was performed in two steps. The first-step estimation was performed on the assumption of orthogonal projection. Then, the second-step estimation was subsequently carried out based upon the perspective projection to accomplish more accurate estimation. The simulation results have demonstrated that the technique archived sufficient accuracies of position/orientation estimation for prosthetic kinematics. Then we applied our algorithm to the CCD images, thereby examining the influences of various artifacts, possibly incorporated through an imaging process, on the estimation accuracies. We found that accuracies in the experiment were influenced mainly by the geometric discrepancies between the prosthesis component and computer generated model and by the spacial inconsistencies between the coordinate axes of the positioner and that of the computer model. However, we verified that our algorithm could achieve proper and consistent estimation even for the CCD images.

Three dimensional perspective view of Mammoth Mountain, California

NASA Technical Reports Server (NTRS)

1994-01-01

This is a three-dimensional perspective of Mammoth Mountain, California. This image was acquired by the Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the Shuttle Endeavour on its 67th orbit, April 13, 1994. This view was constructed by overlaying a SIR-C radar iamage on a U.S. Geological Survey digital elevation Map. Vertical exaggeration is 2X. The image is centered at 37.6 degrees north, 119.0 degrees west. In this color representation, red is C-band HV-polarization, green is C-Band VV-polarization and blue is the ratio of C-Band VV to C-Band HV. Blue areas are smooth and yellow areas are rock outcrops with varying amounts of snow and vegetation. Crowley Lake is in the foreground and Highway 395 crosses in the middle of the image. Mammoth Mountain is shown in the upper right. The Jet Propulsion Laboratory alternative photo number is P-43933.

A physiotherapy perspective of musculoskeletal imaging in sport.

PubMed

Callaghan, M J

2012-08-01

This paper presents a physiotherapy perspective on the role that imaging is now playing in the diagnosis and management of musculoskeletal and sporting injuries. Although the Royal College of Radiologists and the UK Chartered Society of Physiotherapy were founded in the latter part of the nineteenth century, it is 100 years later that developments in the UK NHS have led to increased roles for non-medical healthcare professionals and allied health professionals, such as physiotherapists, in an extended clinical role. Physiotherapists, perhaps because of their knowledge of clinical and applied anatomy, have keenly taken up the opportunities offered to request and interpret imaging in its various forms; the most commonly available are plain radiography, musculoskeletal ultrasound and MRI. This has meant taking formal courses under the auspices of universities with mentorship and tutoring within the clinical setting, which are part of a continuing professional development. The ability to request several forms of imaging has enhanced physiotherapy practice and has increased the appreciation of the responsibilities which accompany this new role.

Time perspective and socioeconomic status: a link to socioeconomic disparities in health?

PubMed

Guthrie, Lori C; Butler, Stephen C; Ward, Michael M

2009-06-01

Time perspective is a measure of the degree to which one's thinking is motivated by considerations of the future, present, or past. Time perspective has been proposed as a potential mediator of socioeconomic disparities in health because it has been associated with health behaviors and is presumed to vary with socioeconomic status. In this cross-sectional community-based survey of respondents recruited from hair salons and barber shops in a suburb of Washington DC, we examined the association between time perspective and both education level and occupation. We asked participants (N=525) to complete a questionnaire that included three subscales (future, present-fatalistic, and present-hedonistic) of the Zimbardo Time Perspective Inventory. Participants with more formal education and those with professional occupations had higher scores on the future time perspective subscale, and lower scores on the present-fatalistic subscale, than participants with less formal education or a non-professional occupation. Present-fatalistic scores were also higher among participants whose parents had less formal education. Present-hedonistic scores were not associated with either education level or professional occupation. Time perspective scores were not independently associated with the likelihood of obesity, smoking, or exercise. In this community sample, future time perspective was associated with current socioeconomic status, and past-fatalistic time perspective was associated with both current and childhood socioeconomic status.

Monocular depth perception using image processing and machine learning

NASA Astrophysics Data System (ADS)

Hombali, Apoorv; Gorde, Vaibhav; Deshpande, Abhishek

2011-10-01

This paper primarily exploits some of the more obscure, but inherent properties of camera and image to propose a simpler and more efficient way of perceiving depth. The proposed method involves the use of a single stationary camera at an unknown perspective and an unknown height to determine depth of an object on unknown terrain. In achieving so a direct correlation between a pixel in an image and the corresponding location in real space has to be formulated. First, a calibration step is undertaken whereby the equation of the plane visible in the field of view is calculated along with the relative distance between camera and plane by using a set of derived spatial geometrical relations coupled with a few intrinsic properties of the system. The depth of an unknown object is then perceived by first extracting the object under observation using a series of image processing steps followed by exploiting the aforementioned mapping of pixel and real space coordinate. The performance of the algorithm is greatly enhanced by the introduction of reinforced learning making the system independent of hardware and environment. Furthermore the depth calculation function is modified with a supervised learning algorithm giving consistent improvement in results. Thus, the system uses the experience in past and optimizes the current run successively. Using the above procedure a series of experiments and trials are carried out to prove the concept and its efficacy.

Imaging utilization commentary: a radiology perspective.

PubMed

Reed, Martin H

2008-11-01

To adhere to the ALARA concept, imaging should be limited to studies that actually contribute to the management of the patient. For example, by applying the Ottawa Ankle Rule and the Ottawa Knee Rule, fewer radiographs are required to evaluate ankle and knee trauma in children. Chest radiographs usually do not contribute to the management of children presenting with typical acute bronchiolitis or asthma, and they can be detrimental because consolidation resulting from retained secretions is interpreted as pneumonia and the child is started on antibiotics unnecessarily. Moreover, a radiograph of the abdomen has poor validity and reproducibility for the diagnosis of constipation. The Pediatric Emergency Care Applied Research Network (PECARN) and the Pediatric Emergency Research in Canada (PERC) are currently developing decision rules for the use of CT in the assessment of minor head injuries in children, which should reduce its utilization in this condition. PECARN is also developing a decision rule for the use of CT in the assessment of abdominal trauma in children. CT is frequently used for the diagnosis of appendicitis in children, but appendicitis can be diagnosed clinically. If imaging is required, appendicitis can often be diagnosed with US, and CT need only be used in the minority of cases where the diagnosis is still in doubt. Utilization guidelines for pediatric imaging studies obtained in children in the emergency setting can improve yield and help in the more efficient management of often scarce health care resources.

Exogenous near-infrared fluorophores and their applications in cancer diagnosis: biological and clinical perspectives.

PubMed

Zhang, Hua; Uselman, Ryan R; Yee, Douglas

2011-05-01

Near-infrared fluorescent (NIRF) imaging is a rapidly growing research field which has the potential to be an important imaging modality in cancer diagnosis. Various exogenous NIR fluorophores have been developed for the technique, including small molecule fluorophores and nanoparticles. NIRF imaging has been used in animal models for the detection of cancer overthe last twenty years and has in recent years been used in human clinical trials. This article describes the types and characteristics of exogenous fluorophores available for in vivo fluorescent cancer imaging. The article also discusses the progression of NIRF cancer imaging over recent years and its future challenges, from both a biological and clinical perspective. in The review also looks at its application for lymph node mapping, tumor targeting and characterization, and tumor margin definition for surgical guidance. NIRF imaging is not in routine clinical cancer practice; yet, the authors predict that techniques using NIR fluorophores for tumor margin definition and lymph node mapping will enter clinical practice in the near future. The authors also anticipate that NIRF imaging research will lead to the development of flurophores with 'high brightness' that will overcome the limited penetration of this modality and be better suited for non invasive tumor targeting.

Put a Brain in Your Camera: Nonstandard Perspectives and Computer Images in the Arts

ERIC Educational Resources Information Center

Reggini, Horacio C.

2011-01-01

Ever since the geometry of central perspective (conical projection) was developed in the XV century, it has been observed that mechanical application of the procedure leads to effects of distortion and exaggeration of shapes and sizes, which often make the result look unnatural. Similar observations are made with the optical projections obtained…

Promoting Issues-Based STSE Perspectives in Science Teacher Education: Problems of Identity and Ideology

ERIC Educational Resources Information Center

Pedretti, Erminia G.; Bencze, Larry; Hewitt, Jim; Romkey, Lisa; Jivraj, Ashifa

2008-01-01

Although science, technology, society and environment (STSE) education has gained considerable force in the past few years, it has made fewer strides in practice. We suggest that "science" teacher identity plays a role in the adoption of STSE perspectives. Simply put, issues-based STSE education challenges traditional images of a science…

Ultrathin endoscopes based on multicore fibers and adaptive optics: a status review and perspectives.

PubMed

Andresen, Esben Ravn; Sivankutty, Siddharth; Tsvirkun, Viktor; Bouwmans, Géraud; Rigneault, Hervé

2016-12-01

We take stock of the progress that has been made into developing ultrathin endoscopes assisted by wave front shaping. We focus our review on multicore fiber-based lensless endoscopes intended for multiphoton imaging applications. We put the work into perspective by comparing with alternative approaches and by outlining the challenges that lie ahead.

Trainee perspectives on postdoctoral recruitment in clinical neuropsychology: reflections on commentaries by Bodin and Grote (2016) and Nelson et al. (2016).

PubMed

Towns, S J; Hahn-Ketter, A E; Halpern, J; Block, C K

2018-01-01

The aim of the current invited paper is to provide the trainees' perspective on recent commentaries on recruitment for postdoctoral fellowship in clinical neuropsychology. The current system of recruitment includes both a match and non-match process and has been problematic for trainees and training programs alike. The author team completed a non-systematic review of previously published commentaries on the current state of postdoctoral fellowship recruitment, which are briefly summarized in the current paper. The trainee perspective is addressed using both survey data and anecdotal experiences of the authors. Trainees report high levels of dissatisfaction with the current dual recruitment system; however, there is no clear preference from trainees for either a match or non-match system. Trainees from both recruitment systems report high levels of satisfaction with their training experience. It seems that either a match or non-match approach, if it led to a unified system, would improve trainee satisfaction.

Image analysis and modeling in medical image computing. Recent developments and advances.

PubMed

Handels, H; Deserno, T M; Meinzer, H-P; Tolxdorff, T

2012-01-01

Medical image computing is of growing importance in medical diagnostics and image-guided therapy. Nowadays, image analysis systems integrating advanced image computing methods are used in practice e.g. to extract quantitative image parameters or to support the surgeon during a navigated intervention. However, the grade of automation, accuracy, reproducibility and robustness of medical image computing methods has to be increased to meet the requirements in clinical routine. In the focus theme, recent developments and advances in the field of modeling and model-based image analysis are described. The introduction of models in the image analysis process enables improvements of image analysis algorithms in terms of automation, accuracy, reproducibility and robustness. Furthermore, model-based image computing techniques open up new perspectives for prediction of organ changes and risk analysis of patients. Selected contributions are assembled to present latest advances in the field. The authors were invited to present their recent work and results based on their outstanding contributions to the Conference on Medical Image Computing BVM 2011 held at the University of Lübeck, Germany. All manuscripts had to pass a comprehensive peer review. Modeling approaches and model-based image analysis methods showing new trends and perspectives in model-based medical image computing are described. Complex models are used in different medical applications and medical images like radiographic images, dual-energy CT images, MR images, diffusion tensor images as well as microscopic images are analyzed. The applications emphasize the high potential and the wide application range of these methods. The use of model-based image analysis methods can improve segmentation quality as well as the accuracy and reproducibility of quantitative image analysis. Furthermore, image-based models enable new insights and can lead to a deeper understanding of complex dynamic mechanisms in the human body. Hence, model-based image computing methods are important tools to improve medical diagnostics and patient treatment in future.

Venus - 3D Perspective View of Sapas Mons

NASA Technical Reports Server (NTRS)

1992-01-01

Sapas Mons is displayed in the center of this computer-generated three-dimensional perspective view of the surface of Venus. The viewpoint is located 527 kilometers (327 miles) northwest of Sapas Mons at an elevation of 4 kilometers (2.5 miles) above the terrain. Lava flows extend for hundreds of kilometers across the fractured plains shown in the foreground to the base of Sapas Mons. The view is to the southeast with Sapas Mons appearing at the center with Maat Mons located in the background on the horizon. Sapas Mons, a volcano 400 kilometers (248 miles) across and 1.5 kilometers (0.9 mile) high is located at approximately 8 degrees north latitude, 188 degrees east longitude, on the western edge of Atla Regio. Its peak sits at an elevation of 4.5 kilometers (2.8 miles) above the planet's mean elevation. Sapas Mons is named for a Phoenician goddess. The vertical scale in this perspective has been exaggerated 10 times. Rays cast in a computer intersect the surface to create a three-dimensional perspective view. Simulated color and a digital elevation map developed by the U.S. Geological Survey are used to enhance small-scale structure. The simulated hues are based on color images recorded by the Soviet Venera 13 and 14 spacecraft. The image was produced by the Solar System Visualization project and the Magellan Science team at the JPL Multimission Image Processing Laboratory and is a single frame from a video released at the April 22, 1992 news conference.

Solar Polar Imager: Observing Coronal Transients from a New Perspective (Invited)

NASA Astrophysics Data System (ADS)

Liewer, P. C.

2013-12-01

The heliophysics community has long recognized the need for a mission to observe the Sun and corona from a polar perspective. One mission concept, the Solar Polar Imager (SPI), has been studied extensively (Liewer et al in NASA Space Science Vision Missions, 2008). In this concept, a solar sail is used to place a spacecraft in a circular 0.48-AU heliocentric orbit with an inclination of ~75 degrees. This orbit enables crucial observations not possible from lower latitude perspectives. Magnetograph and Doppler observations from a polar vantage point would revolutionize our understanding of the mechanism of solar activity cycles, polar magnetic field reversals, the internal structure and dynamics of the Sun and its atmosphere. The rapid 4-month polar orbit combined with both in situ and remote sensing instrumentation further enables unprecedented studies of the physical connection between the Sun, the solar wind, and solar energetic particles. From the polar perspective, white light imagers could be used to track CMEs and predict their arrival at Earth (as demonstrated by STEREO). SPI is also well suited to study the relative roles of CME-driven shock versus flare-associated processes in solar energetic particle acceleration. With the circular 0.48 AU orbit, solar energetic particles could be more easily traced to their sources and their variation with latitude can be studied at a constant radius. This talk will discuss the science objectives, instrumentation and mission design for the SPI mission.

Changing Set: Teaching Family Therapy from a Feminist Perspective.

ERIC Educational Resources Information Center

Leslie, Leigh A.; Clossick, Michelle L.

1992-01-01

Notes that feminist writings in family therapy have critiqued models and offered alternative methods for family interventions. Attempts to expand current application of feminist perspective to family therapy by examining implications for training. Three areas are considered: implications of a feminist perspective for training, strategies for…

Museum spaces as psychological affordances: representations of immigration history and national identity

PubMed Central

Mukherjee, Sahana; Salter, Phia S.; Molina, Ludwin E.

2015-01-01

The present research draws upon a cultural psychological perspective to consider how psychological phenomena are grounded in socio-cultural contexts. Specifically, we examine the association between representations of history at Ellis Island Immigration Museum and identity-relevant concerns. Pilot study participants (N = 13) took a total of 114 photographs of exhibits that they considered as most important in the museum. Results indicate that a majority of the photographs reflected neutral themes (n = 81), followed by nation-glorifying images (n = 24), and then critical themes that highlight injustices and barriers faced by immigrants (n = 9). Study 1 examines whether there is a preference for glorifying images, and if that preference is related to cultural-assimilationist conceptions of national identity (i.e., defining American identity in dominant group standards). We exposed a new sample of participants (N = 119) to photographs reflecting all three themes. Results indicate that participants expressed greater liking for glorifying images, followed by neutral images, and critical images. National identity moderated within-subject variation in liking scores. Study 2 included 35 visitors who completed a survey before engaging with the museum or after their visit. Results indicate that participants who had completed their visit, compared to participants who had not entered the museum, reported (i) higher endorsement of cultural-assimilationist identity, and (ii) increased support for exclusive immigration policies. Study 3 exposed participants (N = 257) to glorifying, critical, or neutral images. Results indicate that participants who were exposed to glorifying images, especially those endorsing cultural-assimilationist identity, demonstrate decreased perception of current-day racial injustice, and increased ethnocentric enforcement bias. We discuss how engagement with privileged narratives may serve dominant group ends and reproduce systems of privilege. PMID:26074846

Quantifying navigational information: The catchment volumes of panoramic snapshots in outdoor scenes.

PubMed

Murray, Trevor; Zeil, Jochen

2017-01-01

Panoramic views of natural environments provide visually navigating animals with two kinds of information: they define locations because image differences increase smoothly with distance from a reference location and they provide compass information, because image differences increase smoothly with rotation away from a reference orientation. The range over which a given reference image can provide navigational guidance (its 'catchment area') has to date been quantified from the perspective of walking animals by determining how image differences develop across the ground plane of natural habitats. However, to understand the information available to flying animals there is a need to characterize the 'catchment volumes' within which panoramic snapshots can provide navigational guidance. We used recently developed camera-based methods for constructing 3D models of natural environments and rendered panoramic views at defined locations within these models with the aim of mapping navigational information in three dimensions. We find that in relatively open woodland habitats, catchment volumes are surprisingly large extending for metres depending on the sensitivity of the viewer to image differences. The size and the shape of catchment volumes depend on the distance of visual features in the environment. Catchment volumes are smaller for reference images close to the ground and become larger for reference images at some distance from the ground and in more open environments. Interestingly, catchment volumes become smaller when only above horizon views are used and also when views include a 1 km distant panorama. We discuss the current limitations of mapping navigational information in natural environments and the relevance of our findings for our understanding of visual navigation in animals and autonomous robots.

Quantifying navigational information: The catchment volumes of panoramic snapshots in outdoor scenes

PubMed Central

Zeil, Jochen

2017-01-01

Panoramic views of natural environments provide visually navigating animals with two kinds of information: they define locations because image differences increase smoothly with distance from a reference location and they provide compass information, because image differences increase smoothly with rotation away from a reference orientation. The range over which a given reference image can provide navigational guidance (its ‘catchment area’) has to date been quantified from the perspective of walking animals by determining how image differences develop across the ground plane of natural habitats. However, to understand the information available to flying animals there is a need to characterize the ‘catchment volumes’ within which panoramic snapshots can provide navigational guidance. We used recently developed camera-based methods for constructing 3D models of natural environments and rendered panoramic views at defined locations within these models with the aim of mapping navigational information in three dimensions. We find that in relatively open woodland habitats, catchment volumes are surprisingly large extending for metres depending on the sensitivity of the viewer to image differences. The size and the shape of catchment volumes depend on the distance of visual features in the environment. Catchment volumes are smaller for reference images close to the ground and become larger for reference images at some distance from the ground and in more open environments. Interestingly, catchment volumes become smaller when only above horizon views are used and also when views include a 1 km distant panorama. We discuss the current limitations of mapping navigational information in natural environments and the relevance of our findings for our understanding of visual navigation in animals and autonomous robots. PMID:29088300

Perspectives on Imaging: Advanced Applications. Introduction and Overview.

ERIC Educational Resources Information Center

Lynch, Clifford A.; Lunin, Lois F.

1991-01-01

Provides an overview of six articles that address relationships between electronic imaging technology and information science. Articles discuss the areas of technology; applications in the fields of visual arts, medicine, and textile history; conceptual foundations; and future visions, including work in virtual reality and cyberspace. (LRW)

ADHD Perspectives: Medicalization and ADHD Connectivity

ERIC Educational Resources Information Center

Wright, Gloria Sunnie

2012-01-01

Today's "ADHDscape" is no longer confined to images of fidgety children falling off classroom chairs. Trans-generational images flood popular culture, from "ADHD creator" with entrepreneurial style, to "ADHD troublemaker". Indeed, ADHD's enigmatic characteristics seem to apply as much to crying babies as to forgetful grannies. With the recent…

Translations of Scientific Practice to "Students' Images of Science"

ERIC Educational Resources Information Center

van Eijck, Michiel; Hsu, Pei-Ling; Roth, Wolff-Michael

2009-01-01

In the science education research literature, it often appears to be assumed that students "possess" more or less stable "images of science" that directly correspond to their experiences with scientific practice in science curricula. From cultural-historical and sociocultural perspectives, this assumption is problematic because scientific…

Virtual Images: Going Through the Looking Glass

NASA Astrophysics Data System (ADS)

Mota, Ana Rita; dos Santos, João Lopes

2017-01-01

Virtual images are often introduced through a "geometric" perspective, with little conceptual or qualitative illustrations, hindering a deeper understanding of this physical concept. In this paper, we present two rather simple observations that force a critical reflection on the optical nature of a virtual image. This approach is supported by the reflect-view, a useful device in geometrical optics classes because it allows a visual confrontation between virtual images and real objects that seemingly occupy the same region of space.

Spectrum Management From A Training Range Perspective

DTIC Science & Technology

2012-01-01

right up to the part where you got killed. • Goose: The defense department regrets to inform you that your sons are dead because they were stupid ...cost (time and lives) 4 Images source: Google images Training Basics • The “prime directives” of training: “Train As You’ll Fight – Fight As...Recording ground truth (movement, C2, actions) – Timely feedback and lessons learned 5 Image source: Google images The Realities of Live Training

Full-wave Characterization of Rough Terrain Surface Effects for Forward-looking Radar Applications: A Scattering and Imaging Study from the Electromagnetic Perspective

DTIC Science & Technology

2011-09-01

and Imaging Framework First, the parallelized 3-D FDTD algorithm is applied to simulate composite scattering from targets in a rough ground...solver as pertinent to forward-looking radar sensing , the effects of surface clutter on multistatic target imaging are illustrated with large-scale...Full-wave Characterization of Rough Terrain Surface Effects for Forward-looking Radar Applications: A Scattering and Imaging Study from the

[Frontiers in Live Bone Imaging Researches. Novel drug discovery by means of intravital bone imaging technology].

PubMed

Ishii, Masaru

2015-06-01

Recent advances in intravital bone imaging technology has enabled us to grasp the real cellular behaviors and functions in vivo , revolutionizing the field of drug discovery for novel therapeutics against intractable bone diseases. In this chapter, I introduce various updated information on pharmacological actions of several antibone resorptive agents, which could only be derived from advanced imaging techniques, and also discuss the future perspectives of this new trend in drug discovery.

Adaptive optics for in-vivo exploration of human retinal structures

NASA Astrophysics Data System (ADS)

Paques, Michel; Meimon, Serge; Grieve, Kate; Rossant, Florence

2017-06-01

Adaptive optics (AO)-enhanced imaging of the retina is now reaching a level of technical maturity which fosters its expanding use in research and clinical centers in the world. By achieving wavelength-limited resolution it did not only allow a better observation of retinal substructures already visible by other means, it also broke anatomical frontiers such as individual photoreceptors or vessel walls. The clinical applications of AO-enhanced imaging has been slower than that of optical coherence tomography because of the combination of technical complexity, costs and the paucity of interpretative scheme of complex data. In several diseases, AO-enhanced imaging has already proven to provide added clinical value and quantitative biomarkers. Here, we will review some of the clinical applications of AO-enhanced en face imaging, and trace perspectives to improve its clinical pertinence in these applications. An interesting perspective is to document cell motion through time-lapse imaging such as during agerelated macular degeneration. In arterial hypertension, the possibility to measure parietal thickness and perform fine morphometric analysis is of interest for monitoring patients. In the near future, implementation of novel approaches and multimodal imaging, including in particular optical coherence tomography, will undoubtedly expand our imaging capabilities. Tackling the technical, scientific and medical challenges offered by high resolution imaging are likely to contribute to our rethinking of many retinal diseases, and, most importantly, may find applications in other areas of medicine.

Turkish Primary Students' Perceptions about Scientist and What Factors Affecting the Image of the Scientists

ERIC Educational Resources Information Center

Turkmen, Hakan

2008-01-01

Students' views of science and scientists have been widely studied. The purpose of this study is to analyze image of scientist from drawn picture of scientists using The Draw-a-Scientist Test (DAST) by 5th grade students and to analyze where this image comes from students minds in changing Turkish educational perspective. Two hundred eighty seven…

Digital Image Manipulation: A Compelling Means to Engage Students in Discussion of Point of View and Perspective

ERIC Educational Resources Information Center

Hofer, Mark; Swan, Kathleen Owings

2005-01-01

With the importance of imagery in our culture and the increasing access to both digital images and the tools used to manipulate them, it is important that social studies teacher educators prepare preservice teachers to provide their students with opportunities to develop a critical lens through which to view images. As we strive to encourage the…

Learning through Work: Emerging Perspectives and New Challenges

ERIC Educational Resources Information Center

Billett, Stephen; Choy, Sarojni

2013-01-01

Purpose: This paper aims to consider and appraise current developments and emerging perspectives on learning in the circumstances of work, to propose how some of the challenges for securing effective workplace learning may be redressed. Design/methodology/approach: First, new challenges and perspectives on learning in the circumstances of work are…

A Discussion of Future Time Perspective

ERIC Educational Resources Information Center

McInerney, Dennis M.

2004-01-01

A growing area of research in educational psychology is future time perspective and its relationship to desired educational outcomes. This article discusses and critiques five reviews of current research on future time perspective. Key questions addressed are when do individuals begin to articulate a future, how far into the future does this…

Research Perspectives and Best Practices in Educational Technology Integration

ERIC Educational Resources Information Center

Keengwe, Jared

2013-01-01

With advancements in technology continuing to influence all areas of society, students in current classrooms have a different understanding and perspective of learning than the educational system has been designed to teach. Research Perspectives and Best Practices in Educational Technology Integration highlights the emerging digital age, its…

Autonomous Learning from a Social Cognitive Perspective

ERIC Educational Resources Information Center

Ponton, Michael K.; Rhea, Nancy E.

2006-01-01

The current perspective of autonomous learning defines it as the agentive exhibition of resourcefulness, initiative, and persistence in self-directed learning. As a form of human agency, it has been argued in the literature that this perspective should be consistent with Bandura's (1986) Social Cognitive Theory (SCT). The purpose of this article…

A Social Theory Perspective on e-Learning

ERIC Educational Resources Information Center

Remtulla, Karim A.

2008-01-01

Current research on e-learning that focuses predominantly on instructional programming, and on various hardware and software, essentially neglects the more socio-cultural perspectives on e-learning. With this in mind, this article proceeds from a social theory perspective with a more socio-culturally engaged look at e-learning for workplace…

NASA's Earth Observations of the Global Environment

NASA Technical Reports Server (NTRS)

King, Michael D.

2005-01-01

A birds eye view of the Earth from afar and up close reveals the power and magnificence of the Earth and juxtaposes the simultaneous impacts and powerlessness of humankind. The NASA Electronic Theater presents Earth science observations and visualizations in an historical perspective. Fly in from outer space to Africa and Cape Town. See the latest spectacular images from NASA & NOAA remote sensing missions like Meteosat, TRMM, Landsat 7, and Terra, which will be visualized and explained in the context of global change. See visualizations of global data sets currently available from Earth orbiting satellites, including the Earth at night with its city lights, aerosols from biomass burning in the Middle East and Africa, and retreat of the glaciers on Mt. Kilimanjaro. See the dynamics of vegetation growth and decay over Africa over 17 years. New visualization tools allow us to roam & zoom through massive global mosaic images including Landsat and Terra tours of Africa and South America, showing land use and land cover change from Bolivian highlands. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa and across the Atlantic to the Caribbean and Amazon basin. See ocean vortexes and currents that bring up the nutrients to feed tiny phytoplankton and draw the fish, pant whales and fisher- man. See how the ocean blooms in response to these currents and El Nino/La Nifia. We will illustrate these and other topics with a dynamic theater-style presentation, along with animations of satellite launch deployments and orbital mapping to highlight aspects of Earth observations from space.

LORENZ: a system for planning long-bone fracture reduction

NASA Astrophysics Data System (ADS)

Birkfellner, Wolfgang; Burgstaller, Wolfgang; Wirth, Joachim; Baumann, Bernard; Jacob, Augustinus L.; Bieri, Kurt; Traud, Stefan; Strub, Michael; Regazzoni, Pietro; Messmer, Peter

2003-05-01

Long bone fractures belong to the most common injuries encountered in clinical routine trauma surgery. Preoperative assessment and decision making is usually based on standard 2D radiographs of the injured limb. Taking into account that a 3D - imaging modality such as computed tomography (CT) is not used for diagnosis in clinical routine, we have designed LORENZ, a fracture reduction planning tool based on such standard radiographs. Taking into account the considerable success of so-called image free navigation systems for total knee replacement in orthopaedic surgery, we assume that a similar tool for long bone fracture reposition should have considerable impact on computer-aided trauma surgery in a standard clinical routine setup. The case for long bone fracture reduction is, however, somewhat more complicated since not only scale independent angles indicating biomechanical measures such as varus and valgus are involved. Reduction path planning requires that the individual anatomy and the classification of the fracture is taken into account. In this paper, we present the basic ideas of this planning tool, it's current state, and the methodology chosen. LORENZ takes one or more conventional radiographs of the broken limb as input data. In addition, one or more x-rays of the opposite healthy bone are taken and mirrored if necessary. A most adequate CT model is being selected from a database; currently, this is achieved by using a scale space approach on the digitized x-ray images and comparing standard perspective renderings to these x-rays. After finding a CT-volume with a similar bone, a triangulated surface model is generated, and the surgeon can break the bone and arrange the fragments in 3D according to the x-ray images of the broken bone. Common osteosynthesis plates and implants can be loaded from CAD-datasets and are visualized as well. In addition, LORENZ renders virtual x-ray views of the fracture reduction process. The hybrid surface/voxel rendering engine of LORENZ also features full collision detection of fragments and implants by using the RAPID collision detection library. The reduction path is saved, and a TCP/IP interface to a robot for executing the reduction was added. LORENZ is platform independent and was programmed using Qt, AVW and OpenGL. We present a prototype for computer-aided fracture reduction planning based on standard radiographs. First test on clinical CT-Xray image pairs showed good performance; a current effort focuses on improving the speed of model retrieval by using orthonormal image moment decomposition, and on clinical evaluation for both training and surgical planning purposes. Furthermore, user-interface aspects are currently under evaluation and will be discussed.

Europa: Perspectives Halfway through the GEM Mission

NASA Astrophysics Data System (ADS)

Chapman, C. R.; Galileo Imaging Team

1998-09-01

We are now nearly a year past the end of the prime Galileo mission (orbital tour) and are approaching the halfway point of the Galileo Europa Mission (GEM). Plans are being formulated for follow-on missions. I will review Galileo results concerning Europa, emphasizing evidence from imaging concerning the near-surface interior of Europa (i.e. the putative sub-ice ocean). It is the photogeologist's difficult task to infer the nature of the subsurface third dimension from two-dimensional images of a planet's surface. The remarkably intricate patterns of ridges, cracks, pits, domes, and chaotic zones on Europa strongly constrain surface processes but are less diagnostic of the subsurface. The issue of time (ages and rates) is always a conundrum in geology and it is especially significant for Europa. Does Europa present us with a frozen tableau of the ancient past or a snapshot of a currently active world with surface units only hundreds of thousands to millions of years old? Is its geological style cyclical or even episodic? Does the evidence for "liquidity" below Europa's brittle crust imply actual water or only low-viscosity ice? If water, how close to the surface is it (a) on average and (b) at the shallowest locations? Galileo's evidence suggests, but has not yet proved, that Europa is the most likely currently habitable place in the solar system beyond the Earth.

Earth Observation taken by the Expedition 25 crew

NASA Image and Video Library

2010-11-19

ISS025-E-017440 (19 Nov. 2010) --- Kamchatka volcanoes are featured in this image photographed by an Expedition 25 crew member on the International Space Station. This striking photograph features several snow-covered volcanoes located on the Kamchatka Peninsula of the Russian Federation, as seen from the orbital perspective of the International Space Station (ISS). This image also illustrates one of the unique attributes provided by the ISS – the ability to view Earth landscapes at an angle, rather than the “straight down” view typical of many orbital satellite-based sensors. This oblique view, together with shadows cast by the volcanoes and other mountains provides perspective about the setting and a sense of topography of the region, especially highlighting the symmetrical cones of Kronotsky (center) and Kizimen (top right) stratovolcanoes. Kizimen Volcano last erupted in 1928, while Kronotsky Volcano—one of the largest on the peninsula—last erupted in 1923. Schmidt Volcano, located to the north of Kronotsky, has the morphology of a shield volcano and is not known to have erupted during the period of historical record. To the south of Kronotsky is Krasheninnikov Volcano, comprised of two overlapping stratovolcanoes that formed within an earlier caldera. Scientists believe Krasheninnikov may have last erupted in 1550. The two summit craters of the stratovolcanoes are clearly visible in this image (lower left). Lake Kronotsky (left) is Kamchatka’s largest lake; it was formed when lava flows from Kronotsky Volcano dammed the Listvenichnaya River. The Kamchatka Peninsula lies along the so-called “Ring of Fire” in the Pacific Ocean. The Ring of Fire is characterized by the presence of active volcanoes and frequent earthquakes; these are associated with the many active subduction and transform boundary zones that ring the Pacific tectonic plate. According to scientists, there are currently 114 volcanoes identified on the Kamchatka Peninsula that have erupted during the Holocene Epoch (approximately 12,000 years ago to the present).

When the Reading Room Meets the Team Room: Resident Perspectives From Radiology and Internal Medicine on the Effect of Personal Communication After Implementing a Resident-Led Radiology Rounds.

PubMed

Klobuka, Andrew J; Lee, John; Buranosky, Raquel; Heller, Matthew

2018-02-13

Current radiology and internal medicine (IM) residents have trained to varying degrees depending on program in the post picture archiving and communication systems implementation era and thus have largely missed out on the benefits of in-person, 2-way communication between radiologists and consulting clinicians. The purpose of this study is to broadly explore resident perspectives from these groups on the desire for personal contact between radiologists and referring physicians and the effect of improved contact on clinical practice. A radiology rounds was implemented in which radiology residents travel to the IM teaching service teams to discuss their inpatients and review ordered imaging biweekly. Surveys were given to both cohorts following 9 months of implementation. A total of 23/49 diagnostic radiology (DR) and 72/197 IM residents responded. In all, 83% of DR and 96% of IM residents desired more personal contact between radiologists and clinicians. Of all, 92% of DR residents agree that contact with referring clinicians changes their approach to a study, 96% of IM residents agree that personal contact with a radiologist has changed patient management in a way that they otherwise would not have done having simply read a report, 85% of DR residents report that more clinician contact will improve resource use, and 96% report that it will improve care quality. Furthermore, 99% of IM residents report that increased access to a radiologist would make selecting the most appropriate imaging study easier in various clinical scenarios. A majority of IM residents prefer radiology reports that provide specific next-step recommendations and that include arrows/key-image series. We conclude that the newest generation of physicians is already attuned to the value of a radiologist who plays an active, in-person role in the clinical decision-making process. Copyright © 2018 Elsevier Inc. All rights reserved.

Wind Patterns in Jupiter's Equatorial Region (Time set 1)

NASA Technical Reports Server (NTRS)

1997-01-01

Wind patterns of Jupiter's equatorial region. This mosaic covers an area of 34,000 kilometers by 22,000 kilometers and was taken using the 756 nanometer (nm) near-infrared continuum filter. The dark region near the center of the mosaic is an equatorial 'hotspot' similar to the Galileo Probe entry site. The near-infrared continuum filter shows the features of Jupiter's main visible cloud deck.

Jupiter's atmospheric circulation is dominated by alternating jets of east/west (zonal) winds. The bands have different widths and wind speeds but have remained constant as long as telescopes and spacecraft have measured them. The top half of these mosaics lies within Jupiter's North Equatorial Belt, a westward (left) current. The bottom half shows part of the Equatorial Zone, a fast moving eastward current. The clouds near the hotspot are the fastest moving features in these mosaics, moving at about 100 meters per second, or 224 miles per hour.

Superimposed on the zonal wind currents is the Jovian 'weather'. The arrows show the winds measured by an observer moving eastward (right) at the speed of the hotspot. (The observer's perspective is that the hotspot is 'still' while the rest of the planet moves around it.) Clouds south of the hotspot appear to be moving towards it, as seen in the flow aligned with cloud streaks to the southwest and in the clockwise flow to the southeast. Interestingly, there is little cloud motion away from the hotspot in any direction. This is consistent with the idea that dry air is converging over this region and sinking, maintaining the cloud-free nature of the hotspot.

North is at the top. The mosaic covers latitudes 1 to 19 degrees and is centered at longitude 336 degrees West. The smallest resolved features are tens of kilometers in size. These images were taken on December 17, 1996, at a range of 1.5 million kilometers by the Solid State Imaging system aboard NASA's Galileo spacecraft.

The Jet Propulsion Laboratory, Pasadena, CA manages the mission for NASA's Office of Space Science, Washington, DC.

This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at URL http://www.jpl.nasa.gov/galileo/sepo

Future of clip-on weapon sights: pros and cons from an applications perspective

NASA Astrophysics Data System (ADS)

Knight, C. Reed; Greenslade, Ken; Francisco, Glen

2015-05-01

US Domestic, International, allied Foreign National Warfighters and Para-Military First Responders (Police, SWAT, Special Operations, Law Enforcement, Government, Security and more) are put in harm's way all the time. To successfully complete their missions and return home safely are the primary goals of these professionals. Tactical product improvements that affect mission effectiveness and solider survivability are pivotal to understanding the past, present and future of Clip-On in-line weapon sights. Clip-On Weapon Sight (WS) technology was deemed an interim solution by the US Government for use until integrated and fused (day/night multi-sensor) Weapon Sights (WSs) were developed/fielded. Clip-On has now become the solution of choice by Users, Warriors, Soldiers and the US Government. SWaP-C (size, weight and power -cost) has been improved through progressive advances in Clip-On Image Intensified (I2), passive thermal, LL-CMOS and fused technology. Clip-On Weapon Sights are now no longer mounting position sensitive. Now they maintain aim point boresight, so they can be used for longer ranges with increased capabilities while utilizing the existing zeroed weapon and daysight optic. Active illuminated low-light level (both analog I2 and digital LL-CMOS) imaging is rightfully a real-world technology, proven to deliver daytime and low-light level identification confidence. Passive thermal imaging is also a real-world technology, proven to deliver daytime, nighttime and all-weather (including dirty battlefield) target detection confidence. Image processing detection algorithms with intelligent analytics provide documented promise to improve confidence by reducing Users, Warriors and Soldiers' work-loads and improving overall system engagement solution outcomes. In order to understand the future of Clip-On in-line weapon sights, addressing pros and cons, this paper starts with an overview of historical weapon sight applications, technologies and stakeholder decisions driving milestone events that helped shape the Clip-On weapon sight industry. Then, this paper systematically reviews current attributes of integrated multispectral wavelength electro-optical imaging systems that successfully (and sometimes unsuccessfully) shape today's Warrior, Soldier and User's net-capabilities. Finally, this paper explores the evolution, pros and cons, of future Clip-On weapon sights, from a manufacturing and real world applications perspective for tomorrow's military soldier and paramilitary first responder.

Multimodal Discourse Analysis of the Movie "Argo"

ERIC Educational Resources Information Center

Bo, Xu

2018-01-01

Based on multimodal discourse theory, this paper makes a multimodal discourse analysis of some shots in the movie "Argo" from the perspective of context of culture, context of situation and meaning of image. Results show that this movie constructs multimodal discourse through particular context, language and image, and successfully…

Smart molecules for imaging, sensing and health (SMITH).

PubMed

Smith, Bradley D

2015-01-01

This autobiographical review provides a personal account of the author's academic journey in supramolecular chemistry, including brief summaries of research efforts in membrane transport, molecular imaging, ion-pair receptors, rotaxane synthesis, squaraine rotaxanes, and synthtavidin technology. The article concludes with a short perspective of likely future directions in biomedical supramolecular chemistry.

Illinois Occupational Skill Standards: Imaging/Pre-Press Cluster.

ERIC Educational Resources Information Center

Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

This document, which is intended as a guide for work force preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the imaging/pre-press cluster. The document begins with a brief overview of the Illinois perspective on occupational skill standards and…

Middle Grade Students' Concept Images of Algebraic Concepts

ERIC Educational Resources Information Center

Tekin-Sitrava, Reyhan

2017-01-01

This study investigates middle school students' concept images of algebraic concepts which are term, constant term, variable, and coefficient. Also, the study aimed to explore their performances in defining these concepts correctly. A phenomenological method was used to support methodological perspective and to reveal the findings of the study.…

Cross-Cultural Perspectives on Assertiveness and Self-Image.

ERIC Educational Resources Information Center

Lau, Estelle Pau-on

In an examination of some relationships between culture, assertiveness, decisionmaking, and self image among Chinese Americans, this paper focuses on themes such as: (1) how cultural factors impinge on individual capability to be assertive; (2) specific ways in which cultural conditioning affects decisionmaking skills and other behavior patterns;…

Image processing methods in two and three dimensions used to animate remotely sensed data. [cloud cover

NASA Technical Reports Server (NTRS)

Hussey, K. J.; Hall, J. R.; Mortensen, R. A.

1986-01-01

Image processing methods and software used to animate nonimaging remotely sensed data on cloud cover are described. Three FORTRAN programs were written in the VICAR2/TAE image processing domain to perform 3D perspective rendering, to interactively select parameters controlling the projection, and to interpolate parameter sets for animation images between key frames. Operation of the 3D programs and transferring the images to film is automated using executive control language and custom hardware to link the computer and camera.

Wave-Optics Analysis of Pupil Imaging

NASA Technical Reports Server (NTRS)

Dean, Bruce H.; Bos, Brent J.

2006-01-01

Pupil imaging performance is analyzed from the perspective of physical optics. A multi-plane diffraction model is constructed by propagating the scalar electromagnetic field, surface by surface, along the optical path comprising the pupil imaging optical system. Modeling results are compared with pupil images collected in the laboratory. The experimental setup, although generic for pupil imaging systems in general, has application to the James Webb Space Telescope (JWST) optical system characterization where the pupil images are used as a constraint to the wavefront sensing and control process. Practical design considerations follow from the diffraction modeling which are discussed in the context of the JWST Observatory.

Spaces of Inclusion: Investigating Place, Positioning and Perspective in Educational Settings through Photo-Elicitation

ERIC Educational Resources Information Center

Dunne, Linda; Hallett, Fiona; Kay, Virginia; Woolhouse, Clare

2018-01-01

This paper presents findings from a collaborative research study which sought to explore perspectives and understandings of the concept of inclusion, as played out in schools and colleges in northwest England, via the use of images. The research had two parts: in the first part, children and young people took photographs in their school setting…

Executive Function Is Necessary for Perspective Selection, Not Level-1 Visual Perspective Calculation: Evidence from a Dual-Task Study of Adults

ERIC Educational Resources Information Center

Qureshi, Adam W.; Apperly, Ian A.; Samson, Dana

2010-01-01

Previous research suggests that perspective-taking and other "theory of mind" processes may be cognitively demanding for adult participants, and may be disrupted by concurrent performance of a secondary task. In the current study, a Level-1 visual perspective task was administered to 32 adults using a dual-task paradigm in which the secondary task…

Body Talk: Body Image Commentary on Queerty.com.

PubMed

Schwartz, Joseph; Grimm, Josh

2016-08-01

In this study, we conducted a content analysis of 243 photographic images of men published on the gay male-oriented blog Queerty.com. We also analyzed 435 user-generated comments from a randomly selected 1-year sample. Focusing on images' body types, we found that the range of body types featured on the blog was quite narrow-the vast majority of images had very low levels of body fat and very high levels of muscularity. Users' body image-related comments typically endorsed and celebrated images; critiques of images were comparatively rare. Perspectives from objectification theory and social comparison theory suggest that the images and commentary found on the blog likely reinforce unhealthy body image in gay male communities.

Real-world visual statistics and infants' first-learned object names.

PubMed

Clerkin, Elizabeth M; Hart, Elizabeth; Rehg, James M; Yu, Chen; Smith, Linda B

2017-01-05

We offer a new solution to the unsolved problem of how infants break into word learning based on the visual statistics of everyday infant-perspective scenes. Images from head camera video captured by 8 1/2 to 10 1/2 month-old infants at 147 at-home mealtime events were analysed for the objects in view. The images were found to be highly cluttered with many different objects in view. However, the frequency distribution of object categories was extremely right skewed such that a very small set of objects was pervasively present-a fact that may substantially reduce the problem of referential ambiguity. The statistical structure of objects in these infant egocentric scenes differs markedly from that in the training sets used in computational models and in experiments on statistical word-referent learning. Therefore, the results also indicate a need to re-examine current explanations of how infants break into word learning.This article is part of the themed issue 'New frontiers for statistical learning in the cognitive sciences'. © 2016 The Author(s).

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

Successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy relatedmore » problems at the molecular level. In this perspective, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.« less

Neuroscience, neurohistory, and the history of science: a tale of two brain images.

PubMed

Fuller, Steve

2014-03-01

This essay introduces a Focus section on "Neurohistory and History of Science" by distinguishing images of the brain as governor and as transducer: the former treat the brain as the executive control center of the body, the latter as an interface between the organism and reality at large. Most of the consternation expressed in the symposium about the advent of neurohistory derives from the brain-as-governor conception, which is rooted in a "biologistic" understanding of humanity that in recent years has become bound up in various nefarious "neoliberal" political and economic agendas. However, given the sophisticated attitude that neurohistory's leading champion, Daniel Smail, displays toward evolutionary theory's potential impact on historical practice, he is perhaps better understood as part of the brain-as-transducer tradition. This tradition, largely suppressed in current representations of neuroscience, has a strong theological provenance, ultimately concerned with our becoming attuned to the divine frequency, not least by extending the powers of the human nervous system through technology. This essay sympathetically explores the implications of this perspective for historical practice.

Gold nanorods based diffusion reflection measurements: current status and perspectives for clinical applications

NASA Astrophysics Data System (ADS)

Ankri, Rinat; Fixler, Dror

2017-07-01

Optical imaging is a powerful tool for investigating the structure and function of tissues. Tissue optical imaging technologies are generally discussed under two broad regimes: microscopic and macroscopic, while the latter is widely investigated in the field of light-tissue interaction. Among the developed optical technologies for tissue investigation, the diffusion reflectance (DR) method is a simple and safe technology. However, this method suffers from low specificity and low signal-to-noise ratio, so the extraction of the tissue properties is not an easy task. In this review, we describe the use of gold nanorods (GNRs) in DR spectroscopy. The GNRs present unique optical properties which enhance the scattering and absorption properties of a tissue. The GNRs can be easily targeted toward abnormal sites in order to improve the DR signal and to distinguish between the healthy and the abnormal sites in the tissue, with high specificity. This article describes the use of the DR-GNRs method for the detection of cancer and atherosclerosis, from light transfer theory, through the extraction of the tissue properties using the diffusion theory and up to DR in vivo measurements.

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging.

PubMed

Burnum-Johnson, Kristin E; Baker, Erin S; Metz, Thomas O

2017-12-01

Successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. In this perspective, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes. Copyright © 2017 IFPA, Elsevier Ltd. Published by Elsevier Ltd.. All rights reserved.

Dynamics Explorer measurements of particles, fields, and plasma drifts over a horse-collar auroral pattern

NASA Technical Reports Server (NTRS)

Sharber, J. R.; Hones, E. W., Jr.; Heelis, R. A.; Craven, J. D.; Frank, L. A.; Maynard, N. C.; Slavin, J. A.; Birn, J.

1992-01-01

As shown from ground-based measurements and satellite-borne imagers, one type of global auroral pattern characteristic of quiet (usually northward IMF) intervals is that of a contracted but thickened emission region of a pattern referred to as 'horse-collar' aurora (Hones et al., 1989). In this report we use the Dynamics Explorer data set to examine a case in which this horse-collar pattern was observed by the DE-1 auroral imager, while at the same time DE-2, at lower altitude, measured precipitating particles, electric and magnetic fields, and plasma drifts. Our analysis shows that, in general, there is close agreement between the optical signatures and the particle precipitation patterns. In many instances, over scales ranging from tens to a few hundred kilometers, electron precipitation features and upward field-aligned currents are observed at locations where the plasma flow gradients indicate negative V-average x E. The particle, plasma, and field measurements made along the satellite track and the 2D perspective of the imager provide a means of determining the configuration of convective flows in the high-latitude ionosphere during this interval of northward IMF. Recent mapping studies are used to relate the low-altitude observations to possible magnetospheric source regions.

Non-Intrusive Laser-Induced Imaging for Speciation and Patternation in High Pressure Gas Turbine Combustors

NASA Technical Reports Server (NTRS)

Locke, Randy J.; Zaller, Michelle M.; Hicks, Yolanda R.; Anderson, Robert C.

1999-01-01

The next generation of was turbine combustors for aerospace applications will be required to meet increasingly stringent constraints on fuel efficiency, noise abatement, and emissions. The power plants being designed to meet these constraints will operate at extreme conditions of temperature and pressure, thereby generating unique challenges to the previously employed diagnostic methodologies. Current efforts at NASA Glenn Research Center (GRC) utilize optically accessible, high pressure flametubes and sector combustor rigs to probe, via advanced nonintrusive laser techniques, the complex flowfields encountered in advanced combustor designs. The fuel-air mixing process is of particular concern for lowering NO(x) emissions generated in lean, premixed engine concepts. Using planar laser-induced fluorescence (PLIF) we have obtained real-time, detailed imaging of the fuel spray distribution for a number of fuel injector over a wide range of operational conditions that closely match those expected in the proposed propulsion systems. Using a novel combination of planar imaging, of fuel fluorescence and computational analysis that allows an examination of the flowfield from any perspective, we have produced spatially and temporally resolved fuel-air distribution maps. These maps provide detailed insight into the fuel injection at actual conditions never before possible, thereby greatly enhancing the evaluation of fuel injector performance and combustion phenomena.

Nonintrusive laser-induced imaging for speciation and patternation in high-pressure gas turbine combustors

NASA Astrophysics Data System (ADS)

Locke, Randy J.; Zaller, Michelle M.; Hicks, Yolanda R.; Anderson, Robert C.

1999-10-01

The next generation of ga turbine combustors for aerospace applications will be required to meet increasingly stringent constraints on fuel efficiency, noise abatement, and emissions. The power plants being designed to meet these constraints will operate at extreme conditions of temperature and pressure, thereby generating unique challenges to the previously employed diagnostic methodologies. Current efforts at NASA Glenn Research Center GRC utilize optically accessible, high-pressure flametubes and sector combustor rigs to probe, via advanced nonintrusive laser techniques, the complex flowfields encountered in advanced combustor designs. The fuel-air mixing process is of particular concern for lowering NOx emissions generated in lean, premixed engine concepts. Using planar laser-induced fluorescence we have obtained real- time, detailed imaging of the fuel spray distribution for a number of fuel injectors over a wide range of operational conditions that closely match those expected in the proposed propulsion systems. Using a novel combination of planar imaging of fuel fluorescence and computational analysis that allows an examination of the flowfield from any perspective, we have produced spatially and temporally resolved fuel-air distribution maps. These maps provide detailed insight into the fuel injection process at actual conditions never before possible, thereby greatly enhancing the evaluation of fuel injector performance and combustion phenomena.

"Please Don't Just Hang a Feather on a Program or Put a Medicine Wheel on Your Logo and Think 'Oh Well, This Will Work'": Theoretical Perspectives of American Indian and Alaska Native Substance Abuse Prevention Programs.

PubMed

Walsh-Buhi, Margaret L

Many current theories guiding substance abuse prevention (SAP) programs stem from Western ideologies, leading to a scarcity of research on theories from, and a disconnect with, Indigenous perspectives. This qualitative research study explored perceptions of theory by SAP researchers (N = 22) working with American Indian and Alaska Native communities. In-depth interviews identified components of Indigenous theoretical perspectives, including cultural elements such as balance, social cohesion, and belonging as being particularly significant and currently absent from many SAP programs. Recommendations for conducting metatheory studies and operationalization of Indigenous perspectives into guiding theoretical underpinnings for future SAP programming are provided.

Perspective View with Landsat Overlay, San Francisco Bay Area, Calif.

NASA Technical Reports Server (NTRS)

2002-01-01

The cities of San Francisco and the East Bay are highlighted in this computer-generated perspective viewed from west of the Golden Gate. San Francisco occupies the peninsula jutting into the picture from the right. Golden Gate Park is the long rectangle near its left end and the Presidiois the green area at its tip, from which Golden Gate Bridge crosses to Marin. Treasure Island is the bright spot above San Francisco and Alcatraz Island is the small smudge below and to the left. Across the bay from San Francisco lie Berkeley (left) and Oakland (right). Mount Diablo, a landmark visible for many miles, rises in the distance at the upper right.

This three-dimensional perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM) and an enhanced false-color Landsat 5 satellite image. Colors are from Landsat bands 3, 2, and 1 as red, green and blue, respectively. Topographic expression is exaggerated two times.

Landsat has been providing visible and infrared views of the Earth since 1972. SRTM elevation data matches the 30-meter (98-foot) resolution of most Landsat images and will substantially help in analyzing the large and growing Landsat image archive.

The Landsat Thematic Mapper image used here came from an on-line mosaic of Landsat images for the continental United States (http://mapus.jpl.nasa.gov), a part of NASA's Digital Earth effort.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) of the U.S. Department of Defense and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, DC.

Size: scale varies in this perspective image Location: 37.5 deg. North lat., 122.3 deg. West lon. Orientation: looking west Image Data: Landsat Bands 3, 2, 1 as red, green, blue, respectively Original Data Resolution: SRTM 1 arcsecond (30 meters or 98 feet), Thematic Mapper 1 arcsecond (30 meters or 98 feet) Date Acquired: February 2000 (SRTM)

Anaglyph of Perspective View with Aerial Photo Overlay Pasadena, California

NASA Technical Reports Server (NTRS)

2000-01-01

This anaglyph is a perspective view that shows the western part of the city of Pasadena, California, looking north toward the San Gabriel Mountains. Red-blue glasses are required to see the 3-D effect. Portions of the cities of Altadena and La Canada-Flintridge are also shown. The image was created from two datasets: the Shuttle Radar Topography Mission (SRTM) supplied the elevation data and U. S. Geological Survey digital aerial photography provided the image detail. The Jet Propulsion Laboratory is the cluster of large buildings left of center, at the base of the mountains. This image shows the power of combining data from different sources to create planning tools to study problems that affect large urban areas. In addition to the well-known earthquake hazards, Southern California is affected by a natural cycle of fire and mudflows. Wildfires can strip the mountains of vegetation, increasing the hazards from flooding and mudflows. Data shown in this image can be used to predict both how wildfires spread over the terrain and how mudflows are channeled down the canyons.

This anaglyph was generated using topographic data from the Shuttle Radar Topography Mission to create two differing perspectives of a single image, one perspective for each eye. Each point in the image is shifted slightly, depending on its elevation. When viewed through special glasses, the result is a view of the Earth's surface in its full three dimensions. Anaglyph glasses cover the left eye with a red filter and cover the right eye with a blue filter.

The Shuttle Radar Topography Mission (SRTM), launched on February 11, 2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, an additional C-band imaging antenna and improved tracking and navigation devices. The mission is a cooperative project between the National Aeronautics and Space Administration (NASA), the National Imagery and Mapping Agency (NIMA) and the German (DLR) and Italian (ASI) space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Earth Science Enterprise, Washington, DC.

Size: 5.8 km (3.6 miles) x 10 km (6.2 miles) Location: 34.16 deg. North lat., 118.16 deg. West lon. Orientation: Looking North Original Data Resolution: SRTM, 30 m; aerial photo, 3 m; no vertical exaggeration Date Acquired: February 16, 2000 Image: NASA/JPL/NIMA