Quantum chemical modeling of enzymatic reactions: the case of histone lysine methyltransferase.

PubMed

Georgieva, Polina; Himo, Fahmi

2010-06-01

Quantum chemical cluster models of enzyme active sites are today an important and powerful tool in the study of various aspects of enzymatic reactivity. This methodology has been applied to a wide spectrum of reactions and many important mechanistic problems have been solved. Herein, we report a systematic study of the reaction mechanism of the histone lysine methyltransferase (HKMT) SET7/9 enzyme, which catalyzes the methylation of the N-terminal histone tail of the chromatin structure. In this study, HKMT SET7/9 serves as a representative case to examine the modeling approach for the important class of methyl transfer enzymes. Active site models of different sizes are used to evaluate the methodology. In particular, the dependence of the calculated energies on the model size, the influence of the dielectric medium, and the particular choice of the dielectric constant are discussed. In addition, we examine the validity of some technical aspects, such as geometry optimization in solvent or with a large basis set, and the use of different density functional methods. Copyright 2010 Wiley Periodicals, Inc.

Hydration: certain basic aspects for developing technical and scientific parameters into the nutrition knowledge

PubMed

Perales-García, Aránzazu; Estévez-Martínez, Isabel; Urrialde, Rafael

2016-07-12

Introduction: Hydration is defined as the water intake coming from food and beverages. Its study has become an area by itself, within the nutrition field. Meaning that in 2010 the European Food Safety Authority (EFSA) approved the water intake recommendations, but the study of this topic implies a rigorous methodology, which represents several issues. Objective: Showing as a glance the main methodological issues in hydration studies. Material and methods: Bibliographic revision of scientific literature. Results: The main methodological issues presented are: sample selection (investigation field and sample design), selection of the method to evaluate hydration status (dilution techniques, bioelectrical impedance, plasmatic and urinary indicators, changes in body composition, water losses and clinic symptoms) selection of the method to evaluate water intake (biomarker, questionnaires, informatics programs, smartphone use, 24-h register, dietary history and food frequency questionnaire), and the main sources of hydration. Conclusions: Hydration status should be understood as a routine model, with daily frequency, according to gender, age, physical activity and environmental conditions. Furthermore, the correct design of the methodology has a special importance in order to take into account all the aspects

The Impact of Explicit Teaching of Methodological Aspects of Physics on Scientistic Beliefs and Interest

ERIC Educational Resources Information Center

Korte, Stefan; Berger, Roland; Hänze, Martin

2017-01-01

We assessed the impact of teaching methodological aspects of physics on students' scientistic beliefs and subject interest in physics in a repeated-measurement design with a total of 142 students of upper secondary physics classes. Students gained knowledge of methodological aspects from the pre-test to the post-test and reported reduced…

A review on non-linear aeroelasticity of high aspect-ratio wings

NASA Astrophysics Data System (ADS)

Afonso, Frederico; Vale, José; Oliveira, Éder; Lau, Fernando; Suleman, Afzal

2017-02-01

Current economic constraints and environmental regulations call for design of more efficient aircraft configurations. An observed trend in aircraft design to reduce the lift induced drag and improve fuel consumption and emissions is to increase the wing aspect-ratio. However, a slender wing is more flexible and subject to higher deflections under the same operating conditions. This effect may lead to changes in dynamic behaviour and in aeroelastic response, potentially resulting in instabilities. Therefore, it is important to take into account geometric non-linearities in the design of high aspect-ratio wings, as well as having accurate computational codes that couple the aerodynamic and structural models in the presence of non-linearities. Here, a review on the state-of-the-art on non-linear aeroelasticity of high aspect-ratio wings is presented. The methodologies employed to analyse high aspect-ratio wings are presented and their applications discussed. Important observations from the state-of-the-art studies are drawn and the current challenges in the field are identified.

Objectivity in psychosocial measurement: what, why, how.

PubMed

Fisher, W P

2000-01-01

This article raises and tries to answer questions concerning what objectivity in psychosocial measurement is, why it is important, and how it can be achieved. Following in the tradition of the Socratic art of maiuetics, objectivity is characterized by the separation of meaning from the geometric, metaphoric, or numeric figure carrying it, allowing an ideal and abstract entity to take on a life of its own. Examples of objective entities start from anything teachable and learnable, but for the purposes of measurement, the meter, gram, volt, and liter are paradigmatic because of their generalizability across observers, instruments, laboratories, samples, applications, etc. Objectivity is important because it is only through it that distinct conceptual entities are meaningfully distinguished. Seen from another angle, objectivity is important because it defines the conditions of the possibility of shared meaning and community. Full objectivity in psychosocial measurement can be achieved only by attending to both its methodological and its social aspects. The methodological aspect has recently achieved some notice in psychosocial measurement, especially in the form of Rasch's probabilistic conjoint models. Objectivity's social aspect has only recently been noticed by historians of science, and has not yet been systematically incorporated in any psychosocial science. An approach to achieving full objectivity in psychosocial measurement is adapted from the ASTM Standard Practice for Conducting an Interlaboratory Study to Determine the Precision of a Test Method (ASTM Committee E-11 on Statistical Methods, 1992).

Quality and Safety Aspects of Cereals (Wheat) and Their Products.

PubMed

Varzakas, Theo

2016-11-17

Cereals and, most specifically, wheat are described in this chapter highlighting on their safety and quality aspects. Moreover, wheat quality aspects are adequately addressed since they are used to characterize dough properties and baking quality. Determination of dough properties is also mentioned and pasta quality is also described in this chapter. Chemometrics-multivariate analysis is one of the analyses carried out. Regarding production weighing/mixing of flours, kneading, extruded wheat flours, and sodium chloride are important processing steps/raw materials used in the manufacturing of pastry products. Staling of cereal-based products is also taken into account. Finally, safety aspects of cereal-based products are well documented with special emphasis on mycotoxins, acrylamide, and near infrared methodology.

Distinctive characteristics of Madeira wine regarding its traditional winemaking and modern analytical methodologies.

PubMed

Perestrelo, Rosa; Albuquerque, Francisco; Rocha, Sílvia M; Câmara, José S

2011-01-01

Madeira wine, a fortified wine produced in Madeira Island, is a special wine among all types of wine due its specific winemaking process. The aim of this chapter is to describe important aspects of Madeira winemaking and some scientific research currently carried out in these particular kinds of wines. The first part of the chapter concerns the most important aspects of winemaking technology used in Madeira wine production. The second part, the more extensive, deals with the different groups of compounds and how these are modified during the various steps of the production process, namely the aging period. Copyright © 2011 Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoogmartens, Rob, E-mail: rob.hoogmartens@uhasselt.be; Van Passel, Steven, E-mail: steven.vanpassel@uhasselt.be; Van Acker, Karel, E-mail: karel.vanacker@lrd.kuleuven.be

Increasing interest in sustainability has led to the development of sustainability assessment tools such as Life Cycle Analysis (LCA), Life Cycle Costing (LCC) and Cost–Benefit Analysis (CBA). Due to methodological disparity of these three tools, conflicting assessment results generate confusion for many policy and business decisions. In order to interpret and integrate assessment results, the paper provides a framework that clarifies the connections and coherence between the included assessment methodologies. Building on this framework, the paper further focuses on key aspects to adapt any of the methodologies to full sustainability assessments. Aspects dealt with in the review are for examplemore » the reported metrics, the scope, data requirements, discounting, product- or project-related and approaches with respect to scarcity and labor requirements. In addition to these key aspects, the review shows that important connections exist: (i) the three tools can cope with social inequality, (ii) processes such as valuation techniques for LCC and CBA are common, (iii) Environmental Impact Assessment (EIA) is used as input in both LCA and CBA and (iv) LCA can be used in parallel with LCC. Furthermore, the most integrated sustainability approach combines elements of LCA and LCC to achieve the Life Cycle Sustainability Assessment (LCSA). The key aspects and the connections referred to in the review are illustrated with a case study on the treatment of end-of-life automotive glass. - Highlights: • Proliferation of assessment tools creates ambiguity and confusion. • The developed assessment framework clarifies connections between assessment tools. • Broadening LCA, key aspects are metric and data requirements. • Broadening LCC, key aspects are scope, time frame and discounting. • Broadening CBA, focus point, timespan, references, labor and scarcity are key.« less

Some methodological aspects of ethics committees' expertise: the Ukrainian example.

PubMed

Pustovit, Svitlana V

2006-01-01

Today local, national and international ethics committees have become an effective means of social regulation in many European countries. Science itself is an important precondition for the development of bioethical knowledge and ethics expertise. Cultural, social, historical and religious preconditions can facilitate different forms and methods of ethics expertise in each country. Ukrainian ethics expertise has some methodological problems connected with its socio-cultural, historical, science and philosophy development particularities. In this context, clarification of some common legitimacies or methodological approaches to ethics committee (EC) phenomena such as globalization, scientization and the prioritization of an ethics paradigm are very important. On the other hand, elaborate study and critical analysis of international experience by Ukraine and other Eastern European countries will provide the integration of their local and national ethics expertises into a world bioethics ethos.

Macroergonomic analysis and design for improved safety and quality performance.

PubMed

Kleiner, B M

1999-01-01

Macroergonomics, which emerged historically after sociotechnical systems theory, quality management, and ergonomics, is presented as the basis for a needed integrative methodology. A macroergonomics methodology was presented in some detail to demonstrate how aspects of microergonomics, total quality management (TQM), and sociotechnical systems (STS) can be triangulated in a common approach. In the context of this methodology, quality and safety were presented as 2 of several important performance criteria. To demonstrate aspects of the methodology, 2 case studies were summarized with safety and quality performance results where available. The first case manipulated both personnel and technical factors to achieve a "safety culture" at a nuclear site. The concept of safety culture is defined in INSAG-4 (International Atomic Energy Agency, 1991). as "that assembly of characteristics and attitudes in organizations and individuals which establishes that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance." The second case described a tire manufacturing intervention to improve quality (as defined by Sink and Tuttle, 1989) through joint consideration of technical and social factors. It was suggested that macroergonomics can yield greater performance than can be achieved through ergonomic intervention alone. Whereas case studies help to make the case, more rigorous formative and summative research is needed to refine and validate the proposed methodology respectively.

The Associations of Intergroup Interactions and School Racial Socialization with Academic Motivation

ERIC Educational Resources Information Center

Byrd, Christy M.

2015-01-01

School racial climate is an important aspect of the school environment that can have significant implications for youths' development. However, existing research is limited by conceptual and methodological concerns that restrict the ability of researchers and educators to identify "what" about and "how" the racial climate is…

Involving People in the Analysis: Listening, Reflecting, Discounting Nothing.

ERIC Educational Resources Information Center

Richardson, Malcolm

2002-01-01

This article explores methodological issues arising from a research project that involved six people with learning difficulties in researching aspects of their own lives. These included how participants were included in data analysis and the researcher's role. It stresses the importance of the researcher listening to participants, taking time to…

Genetic Strategies for Probing Conscientiousness and Its Relationship to Aging

ERIC Educational Resources Information Center

South, Susan C.; Krueger, Robert F.

2014-01-01

Conscientiousness is an important trait for understanding healthy aging. The present article addresses how behavioral and molecular genetics methodologies can aid in furthering explicating the link between conscientiousness and aspects of health and well-being in later life. We review the etiology of conscientiousness documented by both…

Shadow Education: Theory, Analysis and Future Directions--A Rejoinder

ERIC Educational Resources Information Center

Buchmann, Claudia; Condron, Dennis J.; Roscigno, Vincent J.

2010-01-01

The authors welcome and appreciate the comments of Eric Grodsky and Sigal Alon on their article "Shadow Education, American Style: Test Preparation, the SAT and College Enrollment." In their comments, Grodsky takes issue with several important theoretical and methodological aspects of their article and Alon highlights key processes…

Specification Theory, Patterns, and Models in Information Systems Domains: An Exploratory Investigation

ERIC Educational Resources Information Center

Woolridge, Richard William

2010-01-01

Application and project domain specifications are an important aspect of Information Systems (IS) development. Observations of over thirty IS projects suggest dimly perceived structural patterns in specifications that are unaccounted for in research and practice. This investigation utilizes a theory building with case studies methodology to…

Photovoice as Methodology, Pedagogy, and Partnership-Building Tool: A Graduate and Community College Student Collaboration

ERIC Educational Resources Information Center

Latz, Amanda O.; Phelps-Ward, Robin; Royer, Dan; Peters, Tiffany

2016-01-01

Participatory action research, photovoice, diversity, and immersive learning comprised the most important aspects of the Community Colleges and Diversity graduate course taught during the 2014 spring semester. This project involved eight graduate students, five community college students, three community college administrators, and one university…

Naturalistic observation of health-relevant social processes: the electronically activated recorder methodology in psychosomatics.

PubMed

Mehl, Matthias R; Robbins, Megan L; Deters, Fenne Große

2012-05-01

This article introduces a novel observational ambulatory monitoring method called the electronically activated recorder (EAR). The EAR is a digital audio recorder that runs on a handheld computer and periodically and unobtrusively records snippets of ambient sounds from participants' momentary environments. In tracking moment-to-moment ambient sounds, it yields acoustic logs of people's days as they naturally unfold. In sampling only a fraction of the time, it protects participants' privacy and makes large observational studies feasible. As a naturalistic observation method, it provides an observer's account of daily life and is optimized for the objective assessment of audible aspects of social environments, behaviors, and interactions (e.g., habitual preferences for social settings, idiosyncratic interaction styles, subtle emotional expressions). This article discusses the EAR method conceptually and methodologically, reviews prior research with it, and identifies three concrete ways in which it can enrich psychosomatic research. Specifically, it can (a) calibrate psychosocial effects on health against frequencies of real-world behavior; (b) provide ecological observational measures of health-related social processes that are independent of self-report; and (c) help with the assessment of subtle and habitual social behaviors that evade self-report but have important health implications. An important avenue for future research lies in merging traditional self-report-based ambulatory monitoring methods with observational approaches such as the EAR to allow for the simultaneous yet methodologically independent assessment of inner, experiential aspects (e.g., loneliness) and outer, observable aspects (e.g., social isolation) of real-world social processes to reveal their unique effects on health.

Combining users' activity survey and simulators to evaluate human activity recognition systems.

PubMed

Azkune, Gorka; Almeida, Aitor; López-de-Ipiña, Diego; Chen, Liming

2015-04-08

Evaluating human activity recognition systems usually implies following expensive and time-consuming methodologies, where experiments with humans are run with the consequent ethical and legal issues. We propose a novel evaluation methodology to overcome the enumerated problems, which is based on surveys for users and a synthetic dataset generator tool. Surveys allow capturing how different users perform activities of daily living, while the synthetic dataset generator is used to create properly labelled activity datasets modelled with the information extracted from surveys. Important aspects, such as sensor noise, varying time lapses and user erratic behaviour, can also be simulated using the tool. The proposed methodology is shown to have very important advantages that allow researchers to carry out their work more efficiently. To evaluate the approach, a synthetic dataset generated following the proposed methodology is compared to a real dataset computing the similarity between sensor occurrence frequencies. It is concluded that the similarity between both datasets is more than significant.

Auditory psychophysics and perception.

PubMed

Hirsh, I J; Watson, C S

1996-01-01

In this review of auditory psychophysics and perception, we cite some important books, research monographs, and research summaries from the past decade. Within auditory psychophysics, we have singled out some topics of current importance: Cross-Spectral Processing, Timbre and Pitch, and Methodological Developments. Complex sounds and complex listening tasks have been the subject of new studies in auditory perception. We review especially work that concerns auditory pattern perception, with emphasis on temporal aspects of the patterns and on patterns that do not depend on the cognitive structures often involved in the perception of speech and music. Finally, we comment on some aspects of individual difference that are sufficiently important to question the goal of characterizing auditory properties of the typical, average, adult listener. Among the important factors that give rise to these individual differences are those involved in selective processing and attention.

[Meta-analyses of quarks, baryons and mesons--a "Cochrane Collaboration" in particle physics].

PubMed

Sauerland, Stefan; Sauerland, Thankmar; Antes, Gerd; Barnett, R Michael

2002-02-01

Within the last 20 years meta-analysis has become an important research technique in medicine for integrating the results of independent studies. Meta-analytical techniques, however, are much older. In particle physics for 50 years now the properties of huge numbers of particles have been assessed in meta-analyses. The Cochrane Collaboration's counterpart in physics is the Particle Data Group. This article compares methodological and organisational aspects of meta-analyses in medicine and physics. Several interesting parallels exist, especially with regard to methodology.

A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA.

PubMed

Nandi, Anirban; Pan, Sharadwata; Potumarthi, Ravichandra; Danquah, Michael K; Sarethy, Indira P

2014-01-01

Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.

A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA

PubMed Central

Nandi, Anirban; Danquah, Michael K.

2014-01-01

Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA. PMID:25057428

Review of LCA studies of solid waste management systems – Part II: Methodological guidance for a better practice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laurent, Alexis, E-mail: alau@dtu.dk; Clavreul, Julie; Bernstad, Anna

Highlights: • We perform a critical review of 222 LCA studies of solid waste management systems. • We analyse the past LCA practice against the ISO standard and ILCD Handbook guidance. • Malpractices exist in many methodological aspects with large variations among studies. • Many of these aspects are important for the reliability of the results. • We provide detailed recommendations to practitioners of waste management LCAs. - Abstract: Life cycle assessment (LCA) is increasingly used in waste management to identify strategies that prevent or minimise negative impacts on ecosystems, human health or natural resources. However, the quality of themore » provided support to decision- and policy-makers is strongly dependent on a proper conduct of the LCA. How has LCA been applied until now? Are there any inconsistencies in the past practice? To answer these questions, we draw on a critical review of 222 published LCA studies of solid waste management systems. We analyse the past practice against the ISO standard requirements and the ILCD Handbook guidelines for each major step within the goal definition, scope definition, inventory analysis, impact assessment, and interpretation phases of the methodology. Results show that malpractices exist in several aspects of the LCA with large differences across studies. Examples are a frequent neglect of the goal definition, a frequent lack of transparency and precision in the definition of the scope of the study, e.g. an unclear delimitation of the system boundaries, a truncated impact coverage, difficulties in capturing influential local specificities such as representative waste compositions into the inventory, and a frequent lack of essential sensitivity and uncertainty analyses. Many of these aspects are important for the reliability of the results. For each of them, we therefore provide detailed recommendations to practitioners of waste management LCAs.« less

What Is Conscientiousness and How Can It Be Assessed?

ERIC Educational Resources Information Center

Roberts, Brent W.; Lejuez, Carl; Krueger, Robert F.; Richards, Jessica M.; Hill, Patrick L.

2014-01-01

Conscientiousness is a personality construct that is a core determinant of health, positive aging, and human capital. A large body of work has contributed to our understanding of this important aspect of personality, but there are multiple conceptual and methodological issues that complicate our understanding of conscientiousness. Toward this end,…

Assessing the Nature of Science Views of Singaporean Pre-Service Teachers

ERIC Educational Resources Information Center

Thye, Tan Lip; Kwen, Boo Hong

2004-01-01

Despite the many developments in the teaching of science, an aspect that continues to be neglected appears to be the character and nature of science (NOS). This is becoming especially important in the light of recent developments in pedagogy, as, for example, more teachers adopt constructivist methodologies and computing technology enables…

Towards a Methodology to Identify a Talent by Using Psychological Cognitive Prototyping

ERIC Educational Resources Information Center

Hammer, Matthijs H. M.

2015-01-01

Since education became an important aspect of society, teachers have a prelove for highly talented students. Especially young talented people relish profound attention of universities, firms, music ensembles, sports societies and artist groups. In higher education, students are encouraged to develop their unique strong point, named as talents.…

Design and construction principles in nature and architecture.

PubMed

Knippers, Jan; Speck, Thomas

2012-03-01

This paper will focus on how the emerging scientific discipline of biomimetics can bring new insights into the field of architecture. An analysis of both architectural and biological methodologies will show important aspects connecting these two. The foundation of this paper is a case study of convertible structures based on elastic plant movements.

Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects

PubMed Central

Bilo, Grzegorz; Grillo, Andrea; Guida, Valentina; Parati, Gianfranco

2018-01-01

Morning hours are the period of the day characterized by the highest incidence of major cardiovascular events including myocardial infarction, sudden death or stroke. They are also characterized by important neurohormonal changes, in particular, the activation of sympathetic nervous system which usually leads to a rapid increase in blood pressure (BP), known as morning blood pressure surge (MBPS). It was hypothesized that excessive MBPS may be causally involved in the pathogenesis of cardiovascular events occurring in the morning by inducing hemodynamic stress. A number of studies support an independent relationship of MBPS with organ damage, cerebrovascular complications and mortality, although some heterogeneity exists in the available evidence. This may be due to ethnic differences, methodological issues and the confounding relationship of MBPS with other features of 24-hour BP profile, such as nocturnal dipping or BP variability. Several studies are also available dealing with treatment effects on MBPS and indicating the importance of long-acting antihypertensive drugs in this regard. This paper provides an overview of pathophysiologic, methodological, prognostic and therapeutic aspects related to MBPS. PMID:29872338

Psychosomatic aspects of end-stage renal failure.

PubMed

Sensky, T

1993-01-01

End-stage renal failure (ESRD) is more than a typical chronic disease. Its treatment includes features which arguably make this condition unique. Selected psychosomatic aspects of ESRD are reviewed, including psychiatric morbidity, patients' adherence to their treatments, quality of life and the emotional impact on staff involved in treating patients with ESRD. Rather than presenting a comprehensive review of the results of published research, particular emphasis is laid on the critical appraisal of the methodology of published studies, to examine the extent to which these have provided answers to clinically important questions.

[Discovering pathways for health research in dealing with the social movement].

PubMed

Smeke, E L

1993-01-01

This article is about methodology for scientific research in health, where the researcher is an important part of the object of investigation. The implementation of a broad-based Health Reform in Brazil depends on the involvement of users. It is important to guarantee these social rights. Many experiences sharing this concern are going on in this country. Still, research on the relationship between institutional work in health and the Social Movement lacks a predefined methodology. Therefore, the main objectives of this study are the following: to contribute to the discussion of possible ways of approaching the mechanisms of relationships between health and users of health services, and to collaborate with the development of the citizenship process. This work was done through theoretical research on participatory methodology and "action-based research". The following aspects are particularly important: definition of the object of study, self-positioning by the researcher, subjective explanations, documentary surveys and interviews for case studies, and feedback to theory. Finally, the author concludes that this methodology allows for an understanding of some mechanisms that explain the relationship between macro- and micro-structural analyses. In addition, one also observes a maturation process in the research protagonists.

Cation-exchange high-performance liquid chromatography for variant hemoglobins and HbF/A2: What must hematopathologists know about methodology?

PubMed

Sharma, Prashant; Das, Reena

2016-03-26

Cation-exchange high-performance liquid chromatography (CE-HPLC) is a widely used laboratory test to detect variant hemoglobins as well as quantify hemoglobins F and A2 for the diagnosis of thalassemia syndromes. It's versatility, speed, reproducibility and convenience have made CE-HPLC the method of choice to initially screen for hemoglobin disorders. Despite its popularity, several methodological aspects of the technology remain obscure to pathologists and this may have consequences in specific situations. This paper discusses the basic principles of the technique, the initial quality control steps and the interpretation of various controls and variables that are available on the instrument output. Subsequent sections are devoted to methodological considerations that arise during reporting of cases. For instance, common problems of misidentified peaks, totals crossing 100%, causes of total area being above or below acceptable limits and the importance of pre-integration region peaks are dealt with. Ultimately, CE-HPLC remains an investigation, the reporting of which combines in-depth knowledge of the biological basics with more than a working knowledge of the technological aspects of the technique.

Taking a Distributed Perspective: Epistemological and Methodological Tradeoffs in Operationalizing the Leader-Plus Aspect

ERIC Educational Resources Information Center

Spillane, James P.; Camburn, Eric M.; Pustejovsky, James; Pareja, Amber Stitziel; Lewis, Geoff

2008-01-01

Purpose: This paper is concerned with the epistemological and methodological challenges involved in studying the distribution of leadership across people within the school--the leader-plus aspect of a distributed perspective, which it aims to investigate. Design/methodology/approach: The paper examines the entailments of the distributed…

Determination of the Territorial Sea Baseline - Measurement Aspect

NASA Astrophysics Data System (ADS)

Specht, Cezary; Weintrit, Adam; Specht, Mariusz; Dabrowski, Pawel

2017-12-01

Determining the course of the territorial sea baseline (TSB) of the coastal state is the basis for establishing its maritime boundaries, thus becoming indirect part of maritime policy of the state. Besides the following aspects: legal and methodological as described in the conventions, acts, standards and regulations, equally important is the issue of measurement methodology with respect to the boundaries of the territorial sea. The publication discussed accuracy requirements of the TSB measurement implementation, the relationship of sea level with a choice of the method of its determination, and discussed the implementation of such a measurement on a selected example. As the test reservoir was used the 400-meter stretch of the public beach in Gdynia. During the measurements they used the GNSS geodetic receiver operating in real time based on the geodetic network - VRSnet.pl. Additionally, a comparison was made of the applied method with analogous measurements of the TSB performed in 1999.

Practical aspects of protein co-evolution.

PubMed

Ochoa, David; Pazos, Florencio

2014-01-01

Co-evolution is a fundamental aspect of Evolutionary Theory. At the molecular level, co-evolutionary linkages between protein families have been used as indicators of protein interactions and functional relationships from long ago. Due to the complexity of the problem and the amount of genomic data required for these approaches to achieve good performances, it took a relatively long time from the appearance of the first ideas and concepts to the quotidian application of these approaches and their incorporation to the standard toolboxes of bioinformaticians and molecular biologists. Today, these methodologies are mature (both in terms of performance and usability/implementation), and the genomic information that feeds them large enough to allow their general application. This review tries to summarize the current landscape of co-evolution-based methodologies, with a strong emphasis on describing interesting cases where their application to important biological systems, alone or in combination with other computational and experimental approaches, allowed getting new insight into these.

Practical aspects of protein co-evolution

PubMed Central

Ochoa, David; Pazos, Florencio

2014-01-01

Co-evolution is a fundamental aspect of Evolutionary Theory. At the molecular level, co-evolutionary linkages between protein families have been used as indicators of protein interactions and functional relationships from long ago. Due to the complexity of the problem and the amount of genomic data required for these approaches to achieve good performances, it took a relatively long time from the appearance of the first ideas and concepts to the quotidian application of these approaches and their incorporation to the standard toolboxes of bioinformaticians and molecular biologists. Today, these methodologies are mature (both in terms of performance and usability/implementation), and the genomic information that feeds them large enough to allow their general application. This review tries to summarize the current landscape of co-evolution-based methodologies, with a strong emphasis on describing interesting cases where their application to important biological systems, alone or in combination with other computational and experimental approaches, allowed getting new insight into these. PMID:25364721

Foucault, the subject and the research interview: a critique of methods.

PubMed

Fadyl, Joanna K; Nicholls, David A

2013-03-01

Research interviews are a widely used method in qualitative health research and have been adapted to suit a range of methodologies. Just as it is valuable that new approaches are explored, it is also important to continue to examine their appropriate use. In this article, we question the suitability of research interviews for 'history of the present' studies informed by the work of Michel Foucault - a form of qualitative research that is being increasingly employed in the analysis of healthcare systems and processes. We argue that several aspects of research interviewing produce philosophical and methodological complications that can interfere with achieving the aims of the analysis in this type of study. The article comprises an introduction to these tensions and examination of them in relation to key aspects of a Foucauldian philosophical position, and discussion of where this might position researchers when it comes to designing a study. © 2012 Blackwell Publishing Ltd.

Methodological and ethical aspects of randomized controlled clinical trials in minors with malignant diseases.

PubMed

Rothenberger, Lillian G; Henschel, Andreas Dirk; Schrey, Dominik; Becker, Andreas; Boos, Joachim

2011-10-01

Due to the new European regulations for pediatric medications, future clinical trials will include an increasing number of minors. It is therefore important to reconsider and evaluate recent methodological and ethical aspects of clinical trials in minors. The following questions were investigated: How are randomized controlled clinical trials (RCTs) performed in practice? Do investigators take into consideration biomedical ethical principles, explicated for example by Beauchamp and Childress, when planning and conducting a trial? The study was conducted in a descriptive manner. A systematic, algorithm-guided search focusing on RCTs in minors with malignant diseases was carried out in PubMed. One-thousand-nine-hundred-sixty-two publications from 2001 to 2005 were randomized in sequence. The first 1,000 publications were screened according to a priori defined inclusion criteria. One hundred seventy-five publications met the criteria and were reviewed using the SIGN methodological checklist (2004), the CONSORT Statement (2001, section Methods, items 3-12) and indicators for ethical aspects. Seventeen publications were checked by two raters. Information on randomization and blinding was often equivocal. The publications were mainly rated positive for the criteria of the SIGN checklist, and mostly rated negative for the additional items of the CONSORT Statement. Regarding the ethical principles, only few contributions were found in the publications. Inter-rater reliability was good. In the publications analyzed, we found only limited information concerning methods and reflections on ethical principles of the trials. Improvements are thus necessary and possible. We suggest how such trials and their respective publications can be optimized for these aspects. Copyright © 2011 Wiley-Liss, Inc.

Systematic review of guidelines for management of intermediate hepatocellular carcinoma using the Appraisal of Guidelines Research and Evaluation II instrument.

PubMed

Holvoet, Tom; Raevens, Sarah; Vandewynckel, Yves-Paul; Van Biesen, Wim; Geboes, Karen; Van Vlierberghe, Hans

2015-10-01

Hepatocellular carcinoma is the second leading cause of cancer-related mortality worldwide. Multiple guidelines have been developed to assist clinicians in its management. We aimed to explore methodological quality of these guidelines focusing on treatment of intermediate hepatocellular carcinoma by transarterial chemoembolization. A systematic search was performed for Clinical Practice Guidelines and Consensus statements for hepatocellular carcinoma management. Guideline quality was appraised using the Appraisal of Guidelines Research and Evaluation II instrument, which rates guideline development processes across 6 domains: 'Scope and purpose', 'Stakeholder involvement', 'Rigour of development', 'Clarity of presentation', 'Applicability' and 'Editorial independence'. Thematic analysis of guidelines was performed to map differences in recommendations. Quality of 21 included guidelines varied widely, but was overall poor with only one guideline passing the 50% mark on all domains. Key recommendations as (contra)indications and technical aspects were inconsistent between guidelines. Aspects on side effects and health economics were mainly neglected. Methodological quality of guidelines on transarterial chemoembolization in hepatocellular carcinoma management is poor. This results in important discrepancies between guideline recommendations, creating confusion in clinical practice. Incorporation of the Appraisal of Guidelines Research and Evaluation II instrument in guideline development may improve quality of future guidelines by increasing focus on methodological aspects. Copyright © 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Teaching Cardiac Autonomic Function Dynamics Employing the Valsalva (Valsalva-Weber) Maneuver

ERIC Educational Resources Information Center

Junqueira, Luiz Fernando, Jr.

2008-01-01

In this report, a brief history of the Valsalva (Valsalva-Weber) maneuver is outlined, followed by an explanation on the use of this approach for the evaluation of cardiac autonomic function based on underlying heart rate changes. The most important methodological and interpretative aspects of the Valsalva-Weber maneuver are critically updated,…

Training and Action for Patient Safety: Embedding Interprofessional Education for Patient Safety within an Improvement Methodology

ERIC Educational Resources Information Center

Slater, Beverley L.; Lawton, Rebecca; Armitage, Gerry; Bibby, John; Wright, John

2012-01-01

Introduction: Despite an explosion of interest in improving safety and reducing error in health care, one important aspect of patient safety that has received little attention is a systematic approach to education and training for the whole health care workforce. This article describes an evaluation of an innovative multiprofessional, team-based…

Visual Communication in Web Design - Analyzing Visual Communication in Web Design

NASA Astrophysics Data System (ADS)

Thorlacius, Lisbeth

Web sites are rapidly becoming the preferred media choice for information search, company presentation, shopping, entertainment, education, and social contacts. And along with the various forms of communication that the Web offers the aesthetic aspects have begun to play an increasingly important role. However, studies in the design and the relevance of focusing on the aesthetic aspects in planning and using Web sites have only to a smaller degree been subject of theoretical reflection. For example, Miller (2000), Thorlacius (2001, 2002, 2005), Engholm (2002, 2003), and Beaird (2007) have been contributing to set a beginning agenda that address the aesthetic aspects. On the other hand, there is a considerable amount of literature addressing the theoretical and methodological aspects focusing on the technical and functional aspects. In this context it is the aim of this article to introduce a model for analysis of visual communication on websites.

Landslide hazard analysis for pipelines: The case of the Simonette river crossing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grivas, D.A.; Schultz, B.C.; O`Neil, G.

1995-12-31

The overall objective of this study is to develop a probabilistic methodology to analyze landslide hazards and their effects on the safety of buried pipelines. The methodology incorporates a range of models that can accommodate differences in the ground movement modes and the amount and type of information available at various site locations. Two movement modes are considered, namely (a) instantaneous (catastrophic) slides, and (b) gradual ground movement which may result in cumulative displacements over the pipeline design life (30--40 years) that are in excess of allowable values. Probabilistic analysis is applied in each case to address the uncertainties associatedmore » with important factors that control slope stability. Availability of information ranges from relatively well studied, instrumented installations to cases where data is limited to what can be derived from topographic and geologic maps. The methodology distinguishes between procedures applied where there is little information and those that can be used when relatively extensive data is available. important aspects of the methodology are illustrated in a case study involving a pipeline located in Northern Alberta, Canada, in the Simonette river valley.« less

[Methodology of psychiatric case histories].

PubMed

Scherbaum, N; Mirzaian, E

1999-05-01

This paper deals with the methodology of psychiatric case histories. Three types of case histories are differentiated. The didactic case history teaches about the typical aspects of a psychiatric disorder or treatment by using an individual patient as an example. In the heuristic case history the individual case gives rise to challenging established concepts or to generate new hypotheses. Such hypotheses drawn from inductive reasoning have then to be tested using representative samples. The focus of hermeneutic case histories is the significance of pathological behaviour and experience in the context of the biography of an individual patient. So-called psychopathographies of important historical figures can also be differentiated according to these types. Based on these methodological considerations, quality standards for the named types of case histories are stated.

Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology.

PubMed

Brunoni, André R; Tadini, Laura; Fregni, Felipe

2010-03-03

There have been many changes in clinical trials methodology since the introduction of lithium and the beginning of the modern era of psychopharmacology in 1949. The nature and importance of these changes have not been fully addressed to date. As methodological flaws in trials can lead to false-negative or false-positive results, the objective of our study was to evaluate the impact of methodological changes in psychopharmacology clinical research over the past 60 years. We performed a systematic review from 1949 to 2009 on MEDLINE and Web of Science electronic databases, and a hand search of high impact journals on studies of seven major drugs (chlorpromazine, clozapine, risperidone, lithium, fluoxetine and lamotrigine). All controlled studies published 100 months after the first trial were included. Ninety-one studies met our inclusion criteria. We analyzed the major changes in abstract reporting, study design, participants' assessment and enrollment, methodology and statistical analysis. Our results showed that the methodology of psychiatric clinical trials changed substantially, with quality gains in abstract reporting, results reporting, and statistical methodology. Recent trials use more informed consent, periods of washout, intention-to-treat approach and parametric tests. Placebo use remains high and unchanged over time. Clinical trial quality of psychopharmacological studies has changed significantly in most of the aspects we analyzed. There was significant improvement in quality reporting and internal validity. These changes have increased study efficiency; however, there is room for improvement in some aspects such as rating scales, diagnostic criteria and better trial reporting. Therefore, despite the advancements observed, there are still several areas that can be improved in psychopharmacology clinical trials.

Motivation for orthodontic treatment investigated with Q-methodology: patients' and parents' perspectives.

PubMed

Prabakaran, Rema; Seymour, Shiri; Moles, David R; Cunningham, Susan J

2012-08-01

Motivation and cooperation are vital components of orthodontic treatment if a good outcome is to be achieved. In this study, we used Q-methodology to investigate motivating factors among adolescents seeking orthodontic treatment and parents wanting their children to undergo orthodontic treatment. This technique asks participants to rank a series of statements, and the analysis of this ranking then provides insight into the participants' opinions. Each of these complementary studies was divided into 2 phases: interviews to generate a list of reasons for seeking orthodontic treatment and the use of Q-methodology to assess and categorize the relative importance of these reasons for the groups of participants. In the patient study, 32 items were generated from the interviews and placed in order of importance on a Q-methodology grid by 60 patients who were about to commence orthodontic treatment. The rankings were subjected to factor analysis, which categorized the patients' views into groups of shared opinions. The same methodology was used with the parent group, and a Q-methodology grid was designed to accommodate 35 items that were then ranked by the 60 parents. The rankings were subjected to factor analysis as for the patient group. For the patients, factor analysis identified 3 factors, all of which included esthetics, as important. The remaining respondents had more individual viewpoints and did not map to any of the 3 factors. For the parents, factor analysis identified 4 factors, all of which included treatment in adolescence to prevent future problems, as important. This study showed that Q-methodology is a novel and efficient tool that can be used in dental research with few difficulties. It might prove useful for the aspects of care for which subjective views or opinions play an important role. Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

The evaluation of reflective learning from the nursing student's point of view: A mixed method approach.

PubMed

Fernández-Peña, Rosario; Fuentes-Pumarola, Concepció; Malagón-Aguilera, M Carme; Bonmatí-Tomàs, Anna; Bosch-Farré, Cristina; Ballester-Ferrando, David

2016-09-01

Adapting university programmes to European Higher Education Area criteria has required substantial changes in curricula and teaching methodologies. Reflective learning (RL) has attracted growing interest and occupies an important place in the scientific literature on theoretical and methodological aspects of university instruction. However, fewer studies have focused on evaluating the RL methodology from the point of view of nursing students. To assess nursing students' perceptions of the usefulness and challenges of RL methodology. Mixed method design, using a cross-sectional questionnaire and focus group discussion. The research was conducted via self-reported reflective learning questionnaire complemented by focus group discussion. Students provided a positive overall evaluation of RL, highlighting the method's capacity to help them better understand themselves, engage in self-reflection about the learning process, optimize their strengths and discover additional training needs, along with searching for continuous improvement. Nonetheless, RL does not help them as much to plan their learning or identify areas of weakness or needed improvement in knowledge, skills and attitudes. Among the difficulties or challenges, students reported low motivation and lack of familiarity with this type of learning, along with concerns about the privacy of their reflective journals and about the grading criteria. In general, students evaluated RL positively. The results suggest areas of needed improvement related to unfamiliarity with the methodology, ethical aspects of developing a reflective journal and the need for clear evaluation criteria. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Critical Examination of the Teaching Methodologies Pertaining to Distance Learning in Geographic Education: Andragogy in an Adult Online Certificate Program

ERIC Educational Resources Information Center

Schultz, Richard B.

2012-01-01

Differences between student audiences are an important aspect not only of traditional learning in higher education, but also in the distance learning environment. Facilitators of distance learning coursework must be cognizant of the differences which adult students bring to the classroom and their varying expectations and reasons for learning.…

Investigating the application of AOP methodology in development of Financial Accounting Software using Eclipse-AJDT Environment

NASA Astrophysics Data System (ADS)

Sharma, Amita; Sarangdevot, S. S.

2010-11-01

Aspect-Oriented Programming (AOP) methodology has been investigated in development of real world business application software—Financial Accounting Software. Eclipse-AJDT environment has been used as open source enhanced IDE support for programming in AOP language—Aspect J. Crosscutting concerns have been identified and modularized as aspects. This reduces the complexity of the design considerably due to elimination of code scattering and tangling. Improvement in modularity, quality and performance is achieved. The study concludes that AOP methodology in Eclipse-AJDT environment offers powerful support for modular design and implementation of real world quality business software.

Evidence-based development and evaluation of mobile cognitive support apps for people on the autism spectrum: methodological conclusions from two R+D projects.

PubMed

Gyori, Miklos; Stefanik, Krisztina; Kanizsai-Nagy, Ildikó

2015-01-01

A growing body of evidence confirms that mobile digital devices have key potentials as assistive/educational tools for people with autism spectrum disorders. The aim of this paper is to outline key aspects of development and evaluation methodologies that build on, and provide systematic evidence on effects of using such apps. We rely on the results of two R+D projects, both using quantitative and qualitative methods to support development and to evaluate developed apps (n=54 and n=22). Analyzing methodological conclusions from these studies we outline some guidelines for an 'ideal' R+D methodology but we also point to important trade-offs between the need for best systematic evidence and the limitations on development time and costs. We see these trade-offs as a key issue to be resolved in this field.

Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations.

PubMed

Dworkin, Robert H; Turk, Dennis C; Peirce-Sandner, Sarah; Baron, Ralf; Bellamy, Nicholas; Burke, Laurie B; Chappell, Amy; Chartier, Kevin; Cleeland, Charles S; Costello, Ann; Cowan, Penney; Dimitrova, Rozalina; Ellenberg, Susan; Farrar, John T; French, Jacqueline A; Gilron, Ian; Hertz, Sharon; Jadad, Alejandro R; Jay, Gary W; Kalliomäki, Jarkko; Katz, Nathaniel P; Kerns, Robert D; Manning, Donald C; McDermott, Michael P; McGrath, Patrick J; Narayana, Arvind; Porter, Linda; Quessy, Steve; Rappaport, Bob A; Rauschkolb, Christine; Reeve, Bryce B; Rhodes, Thomas; Sampaio, Cristina; Simpson, David M; Stauffer, Joseph W; Stucki, Gerold; Tobias, Jeffrey; White, Richard E; Witter, James

2010-05-01

There has been an increase in the number of chronic pain clinical trials in which the treatments being evaluated did not differ significantly from placebo in the primary efficacy analyses despite previous research suggesting that efficacy could be expected. These findings could reflect a true lack of efficacy or methodological and other aspects of these trials that compromise the demonstration of efficacy. There is substantial variability among chronic pain clinical trials with respect to important research design considerations, and identifying and addressing any methodological weaknesses would enhance the likelihood of demonstrating the analgesic effects of new interventions. An IMMPACT consensus meeting was therefore convened to identify the critical research design considerations for confirmatory chronic pain trials and to make recommendations for their conduct. We present recommendations for the major components of confirmatory chronic pain clinical trials, including participant selection, trial phases and duration, treatment groups and dosing regimens, and types of trials. Increased attention to and research on the methodological aspects of confirmatory chronic pain clinical trials has the potential to enhance their assay sensitivity and ultimately provide more meaningful evaluations of treatments for chronic pain. Copyright 2010 International Association for the Study of Pain. All rights reserved.

User Evaluation of Neonatology Ward Design.

PubMed

Trujillo, Juan Luis Higuera; Aviñó, Antoni Montañana I; Millán, Carmen Llinares

2017-01-01

The object of this article is to identify the set of affective and emotional factors behind users' assessments of a space in a neonatology unit and to propose design guidelines based on these. The importance of the neonatology service and the variety of users place great demands on the space at all levels. Despite the repercussions, the emotional aspects of the environment have received less attention. To avoid incurring limitations in the user mental scheme, this study uses two complementary methodologies: focus group and semantic differential. The (qualitative) focus group methodology provides exploratory information and concepts. The (quantitative) semantic differential methodology then uses these concepts to extract the conceptual structures that users employ in their assessment of the space. Of the total 175 subjects, 31 took part in focus groups and 144 in semantic differential. Five independent concepts were identified: privacy, functionality and professional nature, spaciousness, lighting, and cleanliness. In relation to the importance of the overall positive assessment of the space, the perception of privacy and sensations of dominance and pleasure are fundamental. Six relevant design aspects were also identified: provide spacious surroundings, facilitate sufficient separation between the different posts or cots, use different colors from those usually found in health-care centers, as some aversion was found to white and especially green, design areas with childhood themes, use warm artificial light, and choose user-friendly equipment. Results provide design recommendations of interest and show the possibilities offered by combining both systems to analyze user response.

Connectivity Measures in EEG Microstructural Sleep Elements.

PubMed

Sakellariou, Dimitris; Koupparis, Andreas M; Kokkinos, Vasileios; Koutroumanidis, Michalis; Kostopoulos, George K

2016-01-01

During Non-Rapid Eye Movement sleep (NREM) the brain is relatively disconnected from the environment, while connectedness between brain areas is also decreased. Evidence indicates, that these dynamic connectivity changes are delivered by microstructural elements of sleep: short periods of environmental stimuli evaluation followed by sleep promoting procedures. The connectivity patterns of the latter, among other aspects of sleep microstructure, are still to be fully elucidated. We suggest here a methodology for the assessment and investigation of the connectivity patterns of EEG microstructural elements, such as sleep spindles. The methodology combines techniques in the preprocessing, estimation, error assessing and visualization of results levels in order to allow the detailed examination of the connectivity aspects (levels and directionality of information flow) over frequency and time with notable resolution, while dealing with the volume conduction and EEG reference assessment. The high temporal and frequency resolution of the methodology will allow the association between the microelements and the dynamically forming networks that characterize them, and consequently possibly reveal aspects of the EEG microstructure. The proposed methodology is initially tested on artificially generated signals for proof of concept and subsequently applied to real EEG recordings via a custom built MATLAB-based tool developed for such studies. Preliminary results from 843 fast sleep spindles recorded in whole night sleep of 5 healthy volunteers indicate a prevailing pattern of interactions between centroparietal and frontal regions. We demonstrate hereby, an opening to our knowledge attempt to estimate the scalp EEG connectivity that characterizes fast sleep spindles via an "EEG-element connectivity" methodology we propose. The application of the latter, via a computational tool we developed suggests it is able to investigate the connectivity patterns related to the occurrence of EEG microstructural elements. Network characterization of specified physiological or pathological EEG microstructural elements can potentially be of great importance in the understanding, identification, and prediction of health and disease.

Connectivity Measures in EEG Microstructural Sleep Elements

PubMed Central

Sakellariou, Dimitris; Koupparis, Andreas M.; Kokkinos, Vasileios; Koutroumanidis, Michalis; Kostopoulos, George K.

2016-01-01

During Non-Rapid Eye Movement sleep (NREM) the brain is relatively disconnected from the environment, while connectedness between brain areas is also decreased. Evidence indicates, that these dynamic connectivity changes are delivered by microstructural elements of sleep: short periods of environmental stimuli evaluation followed by sleep promoting procedures. The connectivity patterns of the latter, among other aspects of sleep microstructure, are still to be fully elucidated. We suggest here a methodology for the assessment and investigation of the connectivity patterns of EEG microstructural elements, such as sleep spindles. The methodology combines techniques in the preprocessing, estimation, error assessing and visualization of results levels in order to allow the detailed examination of the connectivity aspects (levels and directionality of information flow) over frequency and time with notable resolution, while dealing with the volume conduction and EEG reference assessment. The high temporal and frequency resolution of the methodology will allow the association between the microelements and the dynamically forming networks that characterize them, and consequently possibly reveal aspects of the EEG microstructure. The proposed methodology is initially tested on artificially generated signals for proof of concept and subsequently applied to real EEG recordings via a custom built MATLAB-based tool developed for such studies. Preliminary results from 843 fast sleep spindles recorded in whole night sleep of 5 healthy volunteers indicate a prevailing pattern of interactions between centroparietal and frontal regions. We demonstrate hereby, an opening to our knowledge attempt to estimate the scalp EEG connectivity that characterizes fast sleep spindles via an “EEG-element connectivity” methodology we propose. The application of the latter, via a computational tool we developed suggests it is able to investigate the connectivity patterns related to the occurrence of EEG microstructural elements. Network characterization of specified physiological or pathological EEG microstructural elements can potentially be of great importance in the understanding, identification, and prediction of health and disease. PMID:26924980

Structural methodologies for auditing SNOMED.

PubMed

Wang, Yue; Halper, Michael; Min, Hua; Perl, Yehoshua; Chen, Yan; Spackman, Kent A

2007-10-01

SNOMED is one of the leading health care terminologies being used worldwide. As such, quality assurance is an important part of its maintenance cycle. Methodologies for auditing SNOMED based on structural aspects of its organization are presented. In particular, automated techniques for partitioning SNOMED into smaller groups of concepts based primarily on relationships patterns are defined. Two abstraction networks, the area taxonomy and p-area taxonomy, are derived from the partitions. The high-level views afforded by these abstraction networks form the basis for systematic auditing. The networks tend to highlight errors that manifest themselves as irregularities at the abstract level. They also support group-based auditing, where sets of purportedly similar concepts are focused on for review. The auditing methodologies are demonstrated on one of SNOMED's top-level hierarchies. Errors discovered during the auditing process are reported.

Interchannel Coupling in the Photoionization of Atoms and Ions in the X-Ray Range

NASA Technical Reports Server (NTRS)

Manson, Steven T.; Chakraborty, Himadri S.; Deshmukh, Pranawa C.

2002-01-01

To understand how this interchannel coupling, so important in neutral atoms, applies to positive ions, a research program has been initiated to deal with this question, i.e., a program to quantify the effects of interchannel coupling in ionic photoionization, thereby assessing existing photoionization data bases in the x-ray region. To accomplish this task, we have employed the Relativistic Random-Phase-Approximation (RRPA) methodology which includes significant aspects of electron-electron correlation, including interchannel coupling. The RRPA methodology has been found to produce excellent agreement with experiment for neutral Ne at photon energies in the 1 keV range.

Bearing design - Historical aspects, present technology and future problems; Proceedings of the International Conference, San Francisco, CA, August 18-21, 1980

NASA Technical Reports Server (NTRS)

Anderson, W. J.

1980-01-01

The considered investigations deal with some of the more important present day and future bearing requirements, and design methodologies available for coping with them. Solutions to many forthcoming bearing problems lie in the utilization of the most advanced materials, design methods, and lubrication techniques. Attention is given to materials for rolling element bearings, numerical analysis techniques and design methodology for rolling element bearing load support systems, lubrication of rolling element bearings, journal bearing design for high speed turbomachinery, design and energy losses in the case of turbulent flow bearings, and fluid film bearing response to dynamic loading.

How Can Curriculum History Benefit from Sociolinguistics? The Importance of Language Controversy in the Making of Citizens in Nineteenth- and Twentieth-Century Europe

ERIC Educational Resources Information Center

Gardin, Matias; Gritter, Kris

2016-01-01

Based on small case-study illustrations from a variety of European countries, this study aims to explore methodological aspects of the study of curriculum history by expanding its traditional research scope. In so doing, it is argued that sociolinguistic issues are essential to this discussion. The main argument is that sociolinguistics and…

The Art and Science of Climate Model Tuning

DOE PAGES

Hourdin, Frederic; Mauritsen, Thorsten; Gettelman, Andrew; ...

2017-03-31

The process of parameter estimation targeting a chosen set of observations is an essential aspect of numerical modeling. This process is usually named tuning in the climate modeling community. In climate models, the variety and complexity of physical processes involved, and their interplay through a wide range of spatial and temporal scales, must be summarized in a series of approximate submodels. Most submodels depend on uncertain parameters. Tuning consists of adjusting the values of these parameters to bring the solution as a whole into line with aspects of the observed climate. Tuning is an essential aspect of climate modeling withmore » its own scientific issues, which is probably not advertised enough outside the community of model developers. Optimization of climate models raises important questions about whether tuning methods a priori constrain the model results in unintended ways that would affect our confidence in climate projections. Here, we present the definition and rationale behind model tuning, review specific methodological aspects, and survey the diversity of tuning approaches used in current climate models. We also discuss the challenges and opportunities in applying so-called objective methods in climate model tuning. Here, we discuss how tuning methodologies may affect fundamental results of climate models, such as climate sensitivity. The article concludes with a series of recommendations to make the process of climate model tuning more transparent.« less

The Art and Science of Climate Model Tuning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hourdin, Frederic; Mauritsen, Thorsten; Gettelman, Andrew

The process of parameter estimation targeting a chosen set of observations is an essential aspect of numerical modeling. This process is usually named tuning in the climate modeling community. In climate models, the variety and complexity of physical processes involved, and their interplay through a wide range of spatial and temporal scales, must be summarized in a series of approximate submodels. Most submodels depend on uncertain parameters. Tuning consists of adjusting the values of these parameters to bring the solution as a whole into line with aspects of the observed climate. Tuning is an essential aspect of climate modeling withmore » its own scientific issues, which is probably not advertised enough outside the community of model developers. Optimization of climate models raises important questions about whether tuning methods a priori constrain the model results in unintended ways that would affect our confidence in climate projections. Here, we present the definition and rationale behind model tuning, review specific methodological aspects, and survey the diversity of tuning approaches used in current climate models. We also discuss the challenges and opportunities in applying so-called objective methods in climate model tuning. Here, we discuss how tuning methodologies may affect fundamental results of climate models, such as climate sensitivity. The article concludes with a series of recommendations to make the process of climate model tuning more transparent.« less

Overview of Seismic Hazard and Vulnerability of Ordinary Buildings in Belgium: Methodological Aspects and Study Cases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barszez, Anne-Marie; Camelbeeck, Thierry; Plumier, Andre

Northwest Europe is a region in which damaging earthquakes exist. Assessing the risks of damages is useful, but this is not an easy work based on exact science.In this paper, we propose a general tool for a first level assessment of seismic risks (rapid diagnosis). General methodological aspects are presented. For a given building, the risk is represented by a volume in a multi-dimensional space. This space is defined by axes representing the main parameters that have an influence on the risk. We notably express the importance of including a parameter to consider the specific value of cultural heritage.Then wemore » apply the proposed tool to analyze and compare methods of seismic risk assessment used in Belgium. They differ by the spatial scale of the studied area. Study cases for the whole Belgian Territory and for part of cities in Liege and Mons (Be) aim also to give some sense of the overall risk in Belgium.« less

Four aspects to make science open "by design" and not as an after-thought.

PubMed

Halchenko, Yaroslav O; Hanke, Michael

2015-01-01

Unrestricted dissemination of methodological developments in neuroimaging became the propelling force in advancing our understanding of brain function. However, despite such a rich legacy, it remains not uncommon to encounter software and datasets that are distributed under unnecessarily restricted terms, or that violate terms of third-party products (software or data). With this brief correspondence we would like to recapitulate four important aspects of scientific research practice, which should be taken into consideration as early as possible in the course of any project. Keeping these in check will help neuroimaging to stay at the forefront of the open science movement.

Millennial Expectations and Constructivist Methodologies: Their Corresponding Characteristics and Alignment

ERIC Educational Resources Information Center

Carter, Timothy L.

2008-01-01

In recent years, much emphasis has been placed on constructivist methodologies and their potential benefit for learners of various ages (Brandt & Perkins, 2000; Brooks, 1990). Although certain aspects of the constructivist paradigm have replaced several aspects of the behaviorist paradigm for a large contingency of stakeholders (particularly,…

The Development of the Foundations of Modern Pedagogy: Paradigmal and Methodological Aspects of Research

ERIC Educational Resources Information Center

Dmitrenko, ?amara ?.; Lavryk, Tatjana V.; Yaresko, Ekaterina V.

2015-01-01

Changes in the various fields of knowledge influenced the pedagogical science. The article explains the structure of the foundations of modern pedagogy through paradigmal and methodological aspects. Bases of modern pedagogy include complex of paradigms, object and subject of science, general and specific principles, methods and technologies.…

Discrete choice experiments in pharmacy: a review of the literature.

PubMed

Naik-Panvelkar, Pradnya; Armour, Carol; Saini, Bandana

2013-02-01

Discrete choice experiments (DCEs) have been widely used to elicit patient preferences for various healthcare services and interventions. The aim of our study was to conduct an in-depth scoping review of the literature and provide a current overview of the progressive application of DCEs within the field of pharmacy. Electronic databases (MEDLINE, EMBASE, SCOPUS, ECONLIT) were searched (January 1990-August 2011) to identify published English language studies using DCEs within the pharmacy context. Data were abstracted with respect to DCE methodology and application to pharmacy. Our search identified 12 studies. The DCE methodology was utilised to elicit preferences for different aspects of pharmacy products, therapy or services. Preferences were elicited from either patients or pharmacists, with just two studies incorporating the views of both. Most reviewed studies examined preferences for process-related or provider-related aspects with a lesser focus on health outcomes. Monetary attributes were considered to be important by most patients and pharmacists in the studies reviewed. Logit, probit or multinomial logit models were most commonly employed for estimation. Our study showed that the pharmacy profession has adopted the DCE methodology consistent with the general health DCEs although the number of studies is quite limited. Future studies need to examine preferences of both patients and providers for particular products or disease-state management services. Incorporation of health outcome attributes in the design, testing for external validity and the incorporation of DCE results in economic evaluation framework to inform pharmacy policy remain important areas for future research. © 2012 The Authors. IJPP © 2012 Royal Pharmaceutical Society.

Naturalistic Observation of Health-Relevant Social Processes: The Electronically Activated Recorder (EAR) Methodology in Psychosomatics

PubMed Central

Mehl, Matthias R.; Robbins, Megan L.; Deters, Fenne große

2012-01-01

This article introduces a novel, observational ambulatory monitoring method called the Electronically Activated Recorder or EAR. The EAR is a digital audio recorder that runs on a handheld computer and periodically and unobtrusively records snippets of ambient sounds from participants’ momentary environments. In tracking moment-to-moment ambient sounds, it yields acoustic logs of people’s days as they naturally unfold. In sampling only a fraction of the time, it protects participants’ privacy and makes large observational studies feasible. As a naturalistic observation method, it provides an observer’s account of daily life and is optimized for the objective assessment of audible aspects of social environments, behaviors, and interactions (e.g., habitual preferences for social settings, idiosyncratic interaction styles, and subtle emotional expressions). The article discusses the EAR method conceptually and methodologically, reviews prior research with it, and identifies three concrete ways in which it can enrich psychosomatic research. Specifically, it can (a) calibrate psychosocial effects on health against frequencies of real-world behavior, (b) provide ecological, observational measures of health-related social processes that are independent of self-report, and (c) help with the assessment of subtle and habitual social behaviors that evade self-report but have important health implications. An important avenue for future research lies in merging traditional, self-report based ambulatory monitoring methods with observational approaches such as the EAR to allow for the simultaneous yet methodologically independent assessment of inner, experiential (e.g., loneliness) and outer, observable aspects (e.g., social isolation) of real-world social processes to reveal their unique effects on health. PMID:22582338

Addressing social aspects associated with wastewater treatment facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Padilla-Rivera, Alejandro; Morgan-Sagastume, Juan Manuel; Noyola, Adalberto

In wastewater treatment facilities (WWTF), technical and financial aspects have been considered a priority, while other issues, such as social aspects, have not been evaluated seriously and there is not an accepted methodology for assessing it. In this work, a methodology focused on social concerns related to WWTF is presented. The methodology proposes the use of 25 indicators as a framework for measuring social performance to evaluate the progress in moving towards sustainability. The methodology was applied to test its applicability and effectiveness in two WWTF in Mexico (urban and rural). This evaluation helped define the key elements, stakeholders andmore » barriers in the facilities. In this context, the urban facility showed a better overall performance, a result that may be explained mainly by the better socioeconomic context of the urban municipality. Finally, the evaluation of social aspects using the semi-qualitative approach proposed in this work allows for a comparison between different facilities and for the identification of strengths and weakness, and it provides an alternative tool for achieving and improving wastewater management. - Highlights: • The methodology proposes 25 indicators as a framework for measuring social performance in wastewater treatment facilities. • The evaluation helped to define the key elements, stakeholders and barriers in the wastewater treatment facilities. • The evaluation of social aspects allows the identification of strengths and weakness for improving wastewater management. • It provides a social profile of the facility that highlights the best and worst performances.« less

Comparison of power curve monitoring methods

NASA Astrophysics Data System (ADS)

Cambron, Philippe; Masson, Christian; Tahan, Antoine; Torres, David; Pelletier, Francis

2017-11-01

Performance monitoring is an important aspect of operating wind farms. This can be done through the power curve monitoring (PCM) of wind turbines (WT). In the past years, important work has been conducted on PCM. Various methodologies have been proposed, each one with interesting results. However, it is difficult to compare these methods because they have been developed using their respective data sets. The objective of this actual work is to compare some of the proposed PCM methods using common data sets. The metric used to compare the PCM methods is the time needed to detect a change in the power curve. Two power curve models will be covered to establish the effect the model type has on the monitoring outcomes. Each model was tested with two control charts. Other methodologies and metrics proposed in the literature for power curve monitoring such as areas under the power curve and the use of statistical copulas have also been covered. Results demonstrate that model-based PCM methods are more reliable at the detecting a performance change than other methodologies and that the effectiveness of the control chart depends on the types of shift observed.

Major challenges for correlational ecological niche model projections to future climate conditions.

PubMed

Peterson, A Townsend; Cobos, Marlon E; Jiménez-García, Daniel

2018-06-20

Species-level forecasts of distributional potential and likely distributional shifts, in the face of changing climates, have become popular in the literature in the past 20 years. Many refinements have been made to the methodology over the years, and the result has been an approach that considers multiple sources of variation in geographic predictions, and how that variation translates into both specific predictions and uncertainty in those predictions. Although numerous previous reviews and overviews of this field have pointed out a series of assumptions and caveats associated with the methodology, three aspects of the methodology have important impacts but have not been treated previously in detail. Here, we assess those three aspects: (1) effects of niche truncation on model transfers to future climate conditions, (2) effects of model selection procedures on future-climate transfers of ecological niche models, and (3) relative contributions of several factors (replicate samples of point data, general circulation models, representative concentration pathways, and alternative model parameterizations) to overall variance in model outcomes. Overall, the view is one of caution: although resulting predictions are fascinating and attractive, this paradigm has pitfalls that may bias and limit confidence in niche model outputs as regards the implications of climate change for species' geographic distributions. © 2018 New York Academy of Sciences.

Methodological aspects of shift-work research.

PubMed

Knutsson, Anders

2004-01-01

A major issue in shift-work research is to understand the possible ways in which shift work can impact performance and health. Nearly all body functions, from those of the cellular level to those of the entire body, are circadian rhythmic. Disturbances of these rhythms as well as the social consequences of odd work hours are of importance for the health and well-being of shift workers. This article reviews a number of common methodological issues which are of relevance to epidemiological studies in this area of research. It discusses conceptual problems regarding the use of the term "shift work," and it underscores the need to develop models that explain the mechanisms of disease in shift workers.

[Oppositional defiant disorder: aspects related to sex differences and informant].

PubMed

Cardo, E; Meisel, V; García-Banda, G; Palmer, C; Riutort, L; Bernad, M; Servera, M

2009-02-27

Oppositional defiant disorder (ODD) is one of the most common externalizing disorders in childhood. ODD prevalence global rates vary from 2% to 16%. Along with conduct disorder and attention deficit disorder, ODD is one of the leading reasons for referral to neuropediatric and psychiatric services. Even though ODD has recognized clinical importance, key aspects of its conceptualization and prevalence in childhood and adolescence remain uncertain. We examine previous research findings of ODD prevalence and analyze sex differences and differences according to informants. ODD prevalence rates present high variability. A number of studies suggest that ODD is more common in boys than in girls. Nevertheless, some authors point that this sex differences may be due to methodological bias. We recommend the validation of an ODD scale that has into consideration the following aspects: level of the subject's development (age), gender and environment.

Utilization of wheel dop based on ergonomic aspects

NASA Astrophysics Data System (ADS)

Widiasih, Wiwin; Murnawan, Hery; Setiawan, Danny

2017-06-01

Time is an important thing in life. People need a tool or equipment to measure time which is divided into two types, namely clock and watch. Everyone needs those kinds of tool. It becomes an opportunity for manufacturer to build a business. However, establishing a business by depending on the demand is not enough, it is necessary to take a consideration of making innovation. Innovation is a difficult thing to find out, but it is not impossible to do it. By creating an innovative product, it can be a strategy to win the competitive market. This study aimed to create an innovative product based on the ergonomic aspects, which was by utilizing wheel dop. This methodology consisted of pre-study, planning and product development, and product analysis. This product utilized wheel dop and was made based on the ergonomic aspects.

Translating between social worlds of policy and everyday life: The development of a group-based method to support policymaking by exploring behavioural aspects of sustainable consumption.

PubMed

Horlick-Jones, Tom; Prades, Ana

2015-10-01

A large international literature on how lay citizens make sense of various aspects of science and technology has been generated by investigations which utilise small group methods. Within that literature, focus group and other group-based methods have come to co-exist, and to some extent, hybridise, with the use of small groups in citizen engagement initiatives. In this article, we report on how we drew upon these methodological developments in the design and operationalisation of a policymaking support tool (STAVE). This tool has been developed to gain insight, in a relatively speedy and cost-effective way, into practical details of the everyday lived experience of people's lives, as relating to the sustainability of corresponding practices. An important challenge we faced was how, in Kuhn's terms, to 'translate' between the forms of life corresponding to the world of policymaking and the world of everyday domestic life. We examine conceptual and methodological aspects of how the tool was designed and assembled, and then trialled in the context of active real-world collaborations with policymaking organisations. These trials were implemented in six European countries, where they were used to support work on live policy issues concerned with sustainable consumption. © The Author(s) 2014.

Quantifying biopsychosocial aspects in everyday contexts: an integrative methodological approach from the behavioral sciences

PubMed Central

Portell, Mariona; Anguera, M Teresa; Hernández-Mendo, Antonio; Jonsson, Gudberg K

2015-01-01

Contextual factors are crucial for evaluative research in psychology, as they provide insights into what works, for whom, in what circumstances, in what respects, and why. Studying behavior in context, however, poses numerous methodological challenges. Although a comprehensive framework for classifying methods seeking to quantify biopsychosocial aspects in everyday contexts was recently proposed, this framework does not contemplate contributions from observational methodology. The aim of this paper is to justify and propose a more general framework that includes observational methodology approaches. Our analysis is rooted in two general concepts: ecological validity and methodological complementarity. We performed a narrative review of the literature on research methods and techniques for studying daily life and describe their shared properties and requirements (collection of data in real time, on repeated occasions, and in natural settings) and classification criteria (eg, variables of interest and level of participant involvement in the data collection process). We provide several examples that illustrate why, despite their higher costs, studies of behavior and experience in everyday contexts offer insights that complement findings provided by other methodological approaches. We urge that observational methodology be included in classifications of research methods and techniques for studying everyday behavior and advocate a renewed commitment to prioritizing ecological validity in behavioral research seeking to quantify biopsychosocial aspects. PMID:26089708

Methodological Aspects of Documenting Civics Lessons in Israel

ERIC Educational Resources Information Center

Cohen, Aviv

2014-01-01

In this paper the author wishes to shed light on some methodological aspects of documenting civics classes as part of educational research. Rooted in the research traditions of grounded theory and the use of ideal types, this study concentrates on one case of a civics course taught in an Israel high school. Touching on the empirical and…

The Impact of Climate Change on the United States Economy

NASA Astrophysics Data System (ADS)

Mendelsohn, Robert; Neumann, James E.

2004-08-01

Understanding the impacts of climate change on economic behaviour is an important aspect of deciding when to take policy actions to prevent or mitigate its consequences. This book applies advanced new economics methodologies to assess impacts on potentially vulnerable aspects of the US economy: agriculture, timber, coastal resources, energy expenditure, fishing, outdoor recreation. It is intended to provide improved understanding of key issues raised in the recent Intergovernmental Panel on Climate Change (IPCC) reports. It concludes that some climate change may produce economic gains in the agriculture and forestry sectors, whereas energy, coastal structures, and water sectors may be harmed. The book will serve as an important reference for the scientific, economic, and policy community, and will also be of interest to natural resource/environmental economists as an example of economic valuation techniques. The volume will clearly be of main importance to researchers and policymakers in the US, but will also be influential as a model for assessment of impacts on economies worldwide.

Adding value to the learning process by online peer review activities: towards the elaboration of a methodology to promote critical thinking in future engineers

NASA Astrophysics Data System (ADS)

Dominguez, Caroline; Nascimento, Maria M.; Payan-Carreira, Rita; Cruz, Gonçalo; Silva, Helena; Lopes, José; Morais, Maria da Felicidade A.; Morais, Eva

2015-09-01

Considering the results of research on the benefits and difficulties of peer review, this paper describes how teaching faculty, interested in endorsing the acquisition of communication and critical thinking (CT) skills among engineering students, has been implementing a learning methodology throughout online peer review activities. While introducing a new methodology, it is important to weight the advantages found and the conditions that might have restrained the activity outcomes, thereby modulating its overall efficiency. Our results show that several factors are decisive for the success of the methodology: the use of specific and detailed orientation guidelines for CT skills, the students' training on how to deliver a meaningful feedback, the opportunity to counter-argument, the selection of good assignments' examples, and the constant teacher's monitoring of the activity. Results also tackle other aspects of the methodology such as the thinking skills evaluation tools (grades and tests) that most suit our reality. An improved methodology is proposed taking in account the encountered limitations, thus offering the possibility to other interested institutions to use/test and/or improve it.

Postcolonial nursing scholarship: from epistemology to method.

PubMed

Kirkham, Sheryl Reiner; Anderson, Joan M

2002-09-01

Postcolonial theory, with its interpretations of race, racialization, and culture, offers nursing scholarship a set of powerful analytic tools unlike those offered by other nursing and social theories. Building on the foundation established by those who first pointed to the importance of incorporating cultural aspects into nursing care, nursing scholarship is in a position to move forward. Critical perspectives such as postcolonialism equip us to meet the epistemological imperative of giving voice to subjugated knowledges and the social mandates of uncovering existing inequities and addressing the social aspects of health and illness. This article makes a case for the integration of postcolonial perspectives into theorizing and sketches out a research methodology based on the postcolonial tradition.

Philosophical Aspects of Space Science

NASA Astrophysics Data System (ADS)

Poghosyan, Gevorg

2015-07-01

The modern astronomy and physics are closely related to the philosophy. If in the past philosophy was largely confined to interpretations of the results obtained by the natural sciences, in the present times it becomes a full member of the scientific research process. Philosophy is currently involved not only in the methodological problems of the natural sciences and formulation process of the general conclusions. In most cases, the philosophical considerations are allowed to make a choice between the different physical hypotheses and assumptions. A unified approach to solving the problems of philosophy and natural sciences becomes more important as the physical and philosophical aspects are often intertwined, forming a mold that defines our knowledge of today's leading edge.

Methodology for research I.

PubMed

Garg, Rakesh

2016-09-01

The conduct of research requires a systematic approach involving diligent planning and its execution as planned. It comprises various essential predefined components such as aims, population, conduct/technique, outcome and statistical considerations. These need to be objective, reliable and in a repeatable format. Hence, the understanding of the basic aspects of methodology is essential for any researcher. This is a narrative review and focuses on various aspects of the methodology for conduct of a clinical research. The relevant keywords were used for literature search from various databases and from bibliographies of the articles.

Qualitative case study methodology in nursing research: an integrative review.

PubMed

Anthony, Susan; Jack, Susan

2009-06-01

This paper is a report of an integrative review conducted to critically analyse the contemporary use of qualitative case study methodology in nursing research. Increasing complexity in health care and increasing use of case study in nursing research support the need for current examination of this methodology. In 2007, a search for case study research (published 2005-2007) indexed in the CINAHL, MEDLINE, EMBASE, PsychINFO, Sociological Abstracts and SCOPUS databases was conducted. A sample of 42 case study research papers met the inclusion criteria. Whittemore and Knafl's integrative review method guided the analysis. Confusion exists about the name, nature and use of case study. This methodology, including terminology and concepts, is often invisible in qualitative study titles and abstracts. Case study is an exclusive methodology and an adjunct to exploring particular aspects of phenomena under investigation in larger or mixed-methods studies. A high quality of case study exists in nursing research. Judicious selection and diligent application of literature review methods promote the development of nursing science. Case study is becoming entrenched in the nursing research lexicon as a well-accepted methodology for studying phenomena in health and social care, and its growing use warrants continued appraisal to promote nursing knowledge development. Attention to all case study elements, process and publication is important in promoting authenticity, methodological quality and visibility.

Future perspectives on space psychology: Recommendations on psychosocial and neurobehavioural aspects of human spaceflight

NASA Astrophysics Data System (ADS)

De La Torre, Gabriel G.; van Baarsen, Berna; Ferlazzo, Fabio; Kanas, Nick; Weiss, Karine; Schneider, Stefan; Whiteley, Iya

2012-12-01

Recently the psychological effects of space flight have gained in attention. In uncovering the psychological challenges that individuals and teams can face, we need research options that integrate psychosocial aspects with behavioral, performance, technical and environmental issues. Future perspectives in Space Psychology and Human Spaceflight are reviewed in this paper. The topics covered include psychosocial and neurobehavioural aspects, neurocognitive testing tools, decision making, autonomy and delayed communications, well being, mental health, situational awareness, and methodology. Authors were members of a European Space Agency (ESA) Research Topical Team on Psychosocial and Behavioral Aspects of Human Spaceflight. They discuss the different topics under a common perspective of a theoretical and practical framework, showing interactions, relationships and possible solutions for the different aspects and variables in play. Recommendations for every topic are offered and summarized for future research in the field. The different proposed research ideas can be accomplished using analogs and simulation experiments, short- and long-duration bed rest, and in-flight microgravity studies. These topics are especially important for future Moon and Mars mission design and training.

Molecular modeling: An open invitation for applied mathematics

NASA Astrophysics Data System (ADS)

Mezey, Paul G.

2013-10-01

Molecular modeling methods provide a very wide range of challenges for innovative mathematical and computational techniques, where often high dimensionality, large sets of data, and complicated interrelations imply a multitude of iterative approximations. The physical and chemical basis of these methodologies involves quantum mechanics with several non-intuitive aspects, where classical interpretation and classical analogies are often misleading or outright wrong. Hence, instead of the everyday, common sense approaches which work so well in engineering, in molecular modeling one often needs to rely on rather abstract mathematical constraints and conditions, again emphasizing the high level of reliance on applied mathematics. Yet, the interdisciplinary aspects of the field of molecular modeling also generates some inertia and perhaps too conservative reliance on tried and tested methodologies, that is at least partially caused by the less than up-to-date involvement in the newest developments in applied mathematics. It is expected that as more applied mathematicians take up the challenge of employing the latest advances of their field in molecular modeling, important breakthroughs may follow. In this presentation some of the current challenges of molecular modeling are discussed.

Business Performance Measurements in Asset Management with the Support of Big Data Technologies

NASA Astrophysics Data System (ADS)

Campos, Jaime; Sharma, Pankaj; Jantunen, Erkki; Baglee, David; Fumagalli, Luca

2017-09-01

The paper reviews the performance measurement in the domain of interest. Important data in asset management are further, discussed. The importance and the characteristics of today's ICTs capabilities are also mentioned in the paper. The role of new concepts such as big data and data mining analytical technologies in managing the performance measurements in asset management are discussed in detail. The authors consequently suggest the use of the modified Balanced Scorecard methodology highlighting both quantitative and qualitative aspects, which is crucial for optimal use of the big data approach and technologies.

Towards improved NDE and SHM methodologies incorporating nonlinear structural features

NASA Astrophysics Data System (ADS)

Chillara, Vamshi Krishna

Ultrasound is widely employed in Nondestructive Evaluation (NDE) and Structural Health Monitoring (SHM) applications to detect and characterize damage/defects in materials. In particular, ultrasonic guided waves are considered a foremost candidate for in-situ monitoring applications. Conventional ultrasonic techniques rely on changes/discontinuities in linear elastic material properties, namely the Young's modulus and shear modulus to detect damage. On the other hand, nonlinear ultrasonic techniques that rely on micro-scale nonlinear material/structural behavior are proven to be sensitive to damage induced microstructural changes that precede macro-scale damage and are hence capable of early damage detection. The goal of this thesis is to investigate the capabilities of nonlinear guided waves --- a fusion of nonlinear ultrasonic techniques with the guided wave methodologies for early damage detection. To that end, the thesis focuses on two important aspects of the problem: 1. Wavemechanics - deals with ultrasonic guided wave propagation in nonlinear waveguides; 2. Micromechanics - deals with correlating ultrasonic response with micro-scale nonlinear material behavior. For the development of efficient NDE and SHM methodologies that incorporate nonlinear structural features, a detailed understanding of the above aspects is indispensable. In this thesis, the wavemechanics aspect of the problem is dealt with from both theoretical and numerical standpoints. A generalized theoretical framework is developed to study higher harmonic guided waves in plates. This was employed to study second harmonic guided waves in pipes using a large-radius asymptotic approximation. Second harmonic guided waves in plates are studied from a numerical standpoint. Theoretical predictions are validated and some key aspects of higher harmonic generation in waveguides are outlined. Finally, second harmonic guided waves in plates with inhomogeneous and localized nonlinearities are studied and some important aspects of guided wave mode selection are addressed. The other part of the work focused on developing a micromechanics based understanding of ultrasonic higher harmonic generation. Three important aspects of micro-scale material behavior, namely tension-compression asymmetry, shearnormal coupling and deformation induced asymmetry are identified and their role in ultrasonic higher harmonic generation is discussed. Tension-compression asymmetry is identified to cause second (even) harmonic generation in materials. Then, shearnormal coupling is identified to cause generation of secondary waves of different polarity than the primary waves. In addition, deformation induced anisotropy due to the presence of residual stress/strain and its contribution to ultrasonic higher harmonic generation is qualitatively discussed. Also, the tension-compression asymmetry in the material is quantified using an energy based measure. The above measure is employed to develop a homogenization based approach amenable to multi-scale analysis to correlate microstructure with ultrasonic higher harmonic generation. Finally, experimental investigations concerning third harmonic SH wave generation in plates are carried out and the effect of load and temperature changes on nonlinear ultrasonic measurements are discussed in the context of SHM. It was found that while nonlinear ultrasound is sensitive to micro-scale damage, the relative nonlinearity parameter may not always be the best measure to quantify the nonlinearity as it is subject to spurious effects from changes in environmental factors such as loads and temperature.

Methodological Aspects of Strategic Development of Regional Socio-Economic System (Following the Example of Radio-Electronic Industry Enterprises in the Republic of Tatarstan)

ERIC Educational Resources Information Center

Uraev, Nikolay N.; Mingaleev, Gaziz F.; Kushimov, Aleksandr T.; Kolesov, Nikolay A.

2016-01-01

This paper considers the methodological aspects of forming a development strategy for the regional socioeconomic system (by the example of radio-electronic enterprises in the Republic of Tatarstan). The paper suggests a conceptual scheme of the macro- and micro-factors' influence on the regional socioeconomic system. This scheme is based on the…

Hypnosis, Ericksonian hypnotherapy, and Aikido.

PubMed

Windle, R; Samko, M

1992-04-01

Several key Ericksonian concepts find cross-cultural validation and practical application in the Japanese martial art of Aikido. The Aikido psychophysiological state of centering shares several important attributes with the trance state, particularly in the relational aspects of shared trance. In Aikido methodology for dealing with others, blending is an almost exact parallel to Ericksonian utilization. The Aikido view of resistance offers an increased understanding of strategic/Ericksonian approaches. Therapist training may be enhanced by combining Aikido principles with traditional methods.

Decade of Venezuela’s President Hugo Chavez, Por Ahora

DTIC Science & Technology

2009-04-01

minor production source of opium and cocoa , Venezuela is important in the transit of narcotics between Columbia and the US. 60 61 Mindful of this, a...took over.91 To highlight the significance of oil to Venezuela , in 2006, oil represented 91% of its exports compared to 80% five years earlier.92...methodology to examine the last ten years of Venezuelas Hugo Chavez presidency and the significant aspects in terms of US security. The paper contents

Non-adiabatic dynamics close to conical intersections and the surface hopping perspective

PubMed Central

Malhado, João Pedro; Bearpark, Michael J.; Hynes, James T.

2014-01-01

Conical intersections play a major role in the current understanding of electronic de-excitation in polyatomic molecules, and thus in the description of photochemistry and photophysics of molecular systems. This article reviews aspects of the basic theory underlying the description of non-adiabatic transitions at conical intersections, with particular emphasis on the important case when the dynamics of the nuclei are treated classically. Within this classical nuclear motion framework, the main aspects of the surface hopping methodology in the conical intersection context are presented. The emerging picture from this treatment is that of electronic transitions around conical intersections dominated by the interplay of the nuclear velocity and the derivative non-adiabatic coupling vector field. PMID:25485263

The "group" in obstetric psychoprophylaxis.

PubMed

Volpe, B; Tenaglia, F; Fede, T; Cerutti, R

1983-01-01

In the practice of obstetric psychoprophylaxis every method employed considered always the group both from a psychological and a pedagogic point of view. Today the group of pregnant women (or couples) is considered under various aspects: - psychological: the group as a support for members with regard to maternal and parental emotional feelings; - anthropological: the group fills up an empty vital space and becomes a "rite de passage" from a state of social identity to another one; - social: the group is a significative cultural intermediary between health services and the women-patient. The knowledge of these aspects becomes an important methodological support for group conductors. We present an analysis of our experience with groups and how this has affected the Psychoprophylaxis in the last years.

Mind-Wandering as a Natural Kind: A Family-Resemblances View.

PubMed

Seli, Paul; Kane, Michael J; Smallwood, Jonathan; Schacter, Daniel L; Maillet, David; Schooler, Jonathan W; Smilek, Daniel

2018-06-01

As empirical research on mind-wandering accelerates, we draw attention to an emerging trend in how mind-wandering is conceptualized. Previously articulated definitions of mind-wandering differ from each other in important ways, yet they also maintain overlapping characteristics. This conceptual structure suggests that mind-wandering is best considered from a family-resemblances perspective, which entails treating it as a graded, heterogeneous construct and clearly measuring and describing the specific aspect(s) of mind-wandering that researchers are investigating. We believe that adopting this family-resemblances approach will increase conceptual and methodological connections among related phenomena in the mind-wandering family and encourage a more nuanced and precise understanding of the many varieties of mind-wandering. Copyright © 2018 Elsevier Ltd. All rights reserved.

Significant events in psychotherapy: An update of research findings.

PubMed

Timulak, Ladislav

2010-11-01

Significant events research represents a specific approach to studying client-identified important moments in the therapy process. The current study provides an overview of the significant events research conducted, the methodology used together with findings and implications. PsychInfo database was searched with keywords such as significant events, important events, significant moments, important moments, and counselling or psychotherapy. The references of the selected studies were also searched. This process led to the identification of 41 primary studies that used client-identified significant event(s) as a main or secondary focus of the study. These were consequently reviewed with regard to their methodology and findings. The findings are presented according to type of study conducted. The impacts of helpful events reported by clients are focused on contributions to therapeutic relationship and to in-session outcomes. Hindering events focus on some client disappointment with the therapist or therapy. The group therapy modality highlighted additional helpful impacts (like learning from others). Perspectives on what is significant in therapy differ between clients and therapists. The intensive qualitative studies reviewed confirm that the processes involved in significant events are complex and ambiguous. Studies show that the helpful events may also contain many hindering elements and that specific events are deeply contextually embedded in the preceding events of therapy. Some studies suggest that helpful significant events are therapeutically productive although this may need to be established further. Specific intensive studies show that the clients' perceptions in therapy may differ dramatically from that of the therapist. Furthermore, the relational and emotional aspects of significant moments may be more important for the clients than the cognitive aspects of therapy which are frequently stressed by therapists. 2010 The British Psychological Society.

A risk assessment methodology to evaluate the risk failure of managed aquifer recharge in the Mediterranean Basin

NASA Astrophysics Data System (ADS)

Rodríguez-Escales, Paula; Canelles, Arnau; Sanchez-Vila, Xavier; Folch, Albert; Kurtzman, Daniel; Rossetto, Rudy; Fernández-Escalante, Enrique; Lobo-Ferreira, João-Paulo; Sapiano, Manuel; San-Sebastián, Jon; Schüth, Christoph

2018-06-01

Managed aquifer recharge (MAR) can be affected by many risks. Those risks are related to different technical and non-technical aspects of recharge, like water availability, water quality, legislation, social issues, etc. Many other works have acknowledged risks of this nature theoretically; however, their quantification and definition has not been developed. In this study, the risk definition and quantification has been performed by means of fault trees and probabilistic risk assessment (PRA). We defined a fault tree with 65 basic events applicable to the operation phase. After that, we have applied this methodology to six different managed aquifer recharge sites located in the Mediterranean Basin (Portugal, Spain, Italy, Malta, and Israel). The probabilities of the basic events were defined by expert criteria, based on the knowledge of the different managers of the facilities. From that, we conclude that in all sites, the perception of the expert criteria of the non-technical aspects were as much or even more important than the technical aspects. Regarding the risk results, we observe that the total risk in three of the six sites was equal to or above 0.90. That would mean that the MAR facilities have a risk of failure equal to or higher than 90 % in the period of 2-6 years. The other three sites presented lower risks (75, 29, and 18 % for Malta, Menashe, and Serchio, respectively).

Examining emotional expressions in discourse: methodological considerations

NASA Astrophysics Data System (ADS)

Hufnagel, Elizabeth; Kelly, Gregory J.

2017-10-01

This methodological paper presents an approach for examining emotional expressions through discourse analysis and ethnographic methods. Drawing on trends in the current literature in science education, we briefly explain the importance of emotions in science education and examine the current research methodologies used in interactional emotion studies. We put forth and substantiate a methodological approach that attends to the interactional, contextual, intertextual, and consequential aspects of emotional expressions. By examining emotional expressions in the discourse in which they are constructed, emotional expressions are identified through semantics, contextualization, and linguistic features. These features make salient four dimensions of emotional expressions: aboutness, frequency, type, and ownership. Drawing on data from a large empirical study of pre-service elementary teachers' emotional expressions about climate change in a science course, we provide illustrative examples to describe what counts as emotional expressions in situ. In doing so we explain how our approach makes salient the nuanced nature of such expressions as well as the broader discourse in which they are constructed and the implications for researching emotional expressions in science education discourse. We suggest reasons why this discourse orientated research methodology can contribute to the interactional study of emotions in science education contexts.

A strategy for developing a launch vehicle system for orbit insertion: Methodological aspects

NASA Astrophysics Data System (ADS)

Klyushnikov, V. Yu.; Kuznetsov, I. I.; Osadchenko, A. S.

2014-12-01

The article addresses methodological aspects of a development strategy to design a launch vehicle system for orbit insertion. The development and implementation of the strategy are broadly outlined. An analysis is provided of the criterial base and input data needed to define the main requirements for the launch vehicle system. Approaches are suggested for solving individual problems in working out the launch vehicle system development strategy.

Human Factors Research in Aircrew Performance and Training: 1990 Annual Summary Report

DTIC Science & Technology

1991-06-01

TRS) . . . . . . . . . 97 DEVELOPMENT OF A METHODOLOGY FOR MEASURING BOTH CONSCIOUS AND SUBCONSCIOUS ASPECTS OF AIRCREW COORDINATION IN ARMY HELICOPTER...Perkin-Elmer mini- computer and FORTRAN programming language. The model was later reprogrammed using the TOSS software and an IBM personal computer. The...will be conducted by the UAFDL. 101 44 DEVELOPMENT OF A METHODOLOGY FOR MEASURING BOTH CONSCIOUS .AND SUBCONSCIOUS ASPECTS OF AIRCREW COORDINATION IN

mRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach

PubMed Central

2014-01-01

Background mRNA translation involves simultaneous movement of multiple ribosomes on the mRNA and is also subject to regulatory mechanisms at different stages. Translation can be described by various codon-based models, including ODE, TASEP, and Petri net models. Although such models have been extensively used, the overlap and differences between these models and the implications of the assumptions of each model has not been systematically elucidated. The selection of the most appropriate modelling framework, and the most appropriate way to develop coarse-grained/fine-grained models in different contexts is not clear. Results We systematically analyze and compare how different modelling methodologies can be used to describe translation. We define various statistically equivalent codon-based simulation algorithms and analyze the importance of the update rule in determining the steady state, an aspect often neglected. Then a novel probabilistic Boolean network (PBN) model is proposed for modelling translation, which enjoys an exact numerical solution. This solution matches those of numerical simulation from other methods and acts as a complementary tool to analytical approximations and simulations. The advantages and limitations of various codon-based models are compared, and illustrated by examples with real biological complexities such as slow codons, premature termination and feedback regulation. Our studies reveal that while different models gives broadly similiar trends in many cases, important differences also arise and can be clearly seen, in the dependence of the translation rate on different parameters. Furthermore, the update rule affects the steady state solution. Conclusions The codon-based models are based on different levels of abstraction. Our analysis suggests that a multiple model approach to understanding translation allows one to ascertain which aspects of the conclusions are robust with respect to the choice of modelling methodology, and when (and why) important differences may arise. This approach also allows for an optimal use of analysis tools, which is especially important when additional complexities or regulatory mechanisms are included. This approach can provide a robust platform for dissecting translation, and results in an improved predictive framework for applications in systems and synthetic biology. PMID:24576337

Advanced piloted aircraft flight control system design methodology. Volume 1: Knowledge base

NASA Technical Reports Server (NTRS)

Mcruer, Duane T.; Myers, Thomas T.

1988-01-01

The development of a comprehensive and electric methodology for conceptual and preliminary design of flight control systems is presented and illustrated. The methodology is focused on the design stages starting with the layout of system requirements and ending when some viable competing system architectures (feedback control structures) are defined. The approach is centered on the human pilot and the aircraft as both the sources of, and the keys to the solution of, many flight control problems. The methodology relies heavily on computational procedures which are highly interactive with the design engineer. To maximize effectiveness, these techniques, as selected and modified to be used together in the methodology, form a cadre of computational tools specifically tailored for integrated flight control system preliminary design purposes. While theory and associated computational means are an important aspect of the design methodology, the lore, knowledge and experience elements, which guide and govern applications are critical features. This material is presented as summary tables, outlines, recipes, empirical data, lists, etc., which encapsulate a great deal of expert knowledge. Much of this is presented in topical knowledge summaries which are attached as Supplements. The composite of the supplements and the main body elements constitutes a first cut at a a Mark 1 Knowledge Base for manned-aircraft flight control.

Extending the Instructional Systems Development Methodology.

ERIC Educational Resources Information Center

O'Neill, Colin E.

1993-01-01

Describes ways that components of Information Engineering (IE) methodology can be used by training system developers to extend Instructional Systems Development (ISD) methodology. Aspects of IE that are useful in ISD are described, including requirements determination, group facilitation, integrated automated tool support, and prototyping.…

Combined UMC- DFT prediction of electron-hole coupling in unit cells of pentacene crystals.

PubMed

Leal, Luciano Almeida; de Souza Júnior, Rafael Timóteo; de Almeida Fonseca, Antonio Luciano; Ribeiro Junior, Luiz Antonio; Blawid, Stefan; da Silva Filho, Demetrio Antonio; da Cunha, Wiliam Ferreira

2017-05-01

Pentacene is an organic semiconductor that draws special attention from the scientific community due to the high mobility of its charge carriers. As electron-hole interactions are important aspects in the regard of such property, a computationally inexpensive method to predict the coupling between these quasi-particles is highly desired. In this work, we propose a hybrid methodology of combining Uncoupled Monte Carlo Simulations (UMC) and Density functional Theory (DFT) methodologies to obtain a good compromise between computational feasibility and accuracy. As a first step in considering a Pentacene crystal, we describe its unit cell: the Pentacene Dimer. Because many conformations can be encountered for the dimer and considering the complexity of the system, we make use of UMC in order to find the most probable structures and relative orientations for the Pentacene-Pentacene complex. Following, we carry out electronic structure calculations in the scope of DFT with the goal of describing the electron-hole coupling on the most probable configurations obtained by UMC. The comparison of our results with previously reported data on the literature suggests that the methodology is well suited for describing transfer integrals of organic semiconductors. The observed accuracy together with the smaller computational cost required by our approach allows us to conclude that such methodology might be an important tool towards the description of systems with higher complexity.

Methodologies of Research into Gender and Other Social Differences within a Multi-Faceted Conception of Social Justice

ERIC Educational Resources Information Center

Evans, Jeff; Tsatsaroni, Anna

2008-01-01

Our discussion of social justice begins by embracing both "distribution" and "recognition" aspects of social relations (Vincent, 2003). The first aspect considers the way that goods, knowledge, skills, rights, etc. are distributed among social groups; the second aspect focuses on aspects of society structuring social encounters…

The Role of Measuring in the Learning of Environmental Occupations and Some Aspects of Environmental Methodology

ERIC Educational Resources Information Center

István, Lüko

2016-01-01

The methodology neglected area of pedagogy, within the environmental specialist teaching methodology cultivating the best part is incomplete. In this article I shall attempt to environmental methodology presented in one part of the University of West Environmental Education workshop, based on the measurement of experiential learning as an…

Algebra for Enterprise Ontology: towards analysis and synthesis of enterprise models

NASA Astrophysics Data System (ADS)

Suga, Tetsuya; Iijima, Junichi

2018-03-01

Enterprise modeling methodologies have made enterprises more likely to be the object of systems engineering rather than craftsmanship. However, the current state of research in enterprise modeling methodologies lacks investigations of the mathematical background embedded in these methodologies. Abstract algebra, a broad subfield of mathematics, and the study of algebraic structures may provide interesting implications in both theory and practice. Therefore, this research gives an empirical challenge to establish an algebraic structure for one aspect model proposed in Design & Engineering Methodology for Organizations (DEMO), which is a major enterprise modeling methodology in the spotlight as a modeling principle to capture the skeleton of enterprises for developing enterprise information systems. The results show that the aspect model behaves well in the sense of algebraic operations and indeed constructs a Boolean algebra. This article also discusses comparisons with other modeling languages and suggests future work.

An overview of systematic review.

PubMed

Baker, Kathy A; Weeks, Susan Mace

2014-12-01

Systematic review is an invaluable tool for the practicing clinician. A well-designed systematic review represents the latest and most complete information available on a particular topic or intervention. This article highlights the key elements of systematic review, what it is and is not, and provides an overview of several reputable organizations supporting the methodological development and conduct of systematic review. Important aspects for evaluating the quality of a systematic review are also included. Copyright © 2014 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.

PubMed

Asan, Esther; Drenckhahn, Detlev

2008-12-01

Investigations of cell and tissue structure and function using innovative methods and approaches have again yielded numerous exciting findings in recent months and have added important data to current knowledge, inspiring new ideas and hypotheses in various fields of modern life sciences. Topics and contents of comprehensive expert reviews covering different aspects in methodological advances, cell biology, tissue function and morphology, and novel findings reported in original papers are summarized in the present review.

Actionable Cultural Understanding for Support to Tactical Operations (ACUSTO): Toward a New Methodological Template for Spatial Decision Support System

DTIC Science & Technology

2009-05-01

gangs. Important aspects of these are the concept of micro locations, or “set space” where gangs tend to locate ( Tita et al. 2005) and patterns of...spatial diffusion of gang activity (Cohen and Tita 1999, Tita and Cohen 2004). A particularly promising approach is the combination of concepts from...matches their social interaction ( Tita 2007, Tita and Ridgeway 2007). An illustration of the incorporation of insights from a spatial analysis into

The Impact of Explicit Teaching of Methodological Aspects of Physics on Scientistic Beliefs and Interest

NASA Astrophysics Data System (ADS)

Korte, Stefan; Berger, Roland; Hänze, Martin

2017-05-01

We assessed the impact of teaching methodological aspects of physics on students' scientistic beliefs and subject interest in physics in a repeated-measurement design with a total of 142 students of upper secondary physics classes. Students gained knowledge of methodological aspects from the pre-test to the post-test and reported reduced scientistic beliefs, both from their own views and from their presumed prototypical physicists' views. We found no direct impact of teaching on students' subject interest in physics. As path analysis indicates, this result can be traced back to opposing paths: Lower scientistic beliefs of students attenuate subject interest while lower presumed scientistic beliefs that they hold of physicists foster subject interest. This finding is in accordance with the self-to-prototype matching theory that predicts an impact of the overlap between students' self-image and their prototypical image on subject interest in physics.

Characteristics and Methodological Quality of Meta-Analyses on Hypertension Treatments-A Cross-Sectional Study.

PubMed

Wu, Xin Yin; Du, Xin Jian; Ho, Robin S T; Lee, Clarence C Y; Yip, Benjamin H K; Wong, Martin C S; Wong, Samuel Y S; Chung, Vincent C H

2017-02-01

Methodological quality of meta-analyses on hypertension treatments can affect treatment decision-making. The authors conducted a cross-sectional study to investigate the methodological quality of meta-analyses on hypertension treatments. One hundred and fifty-eight meta-analyses were identified. Overall, methodological quality was unsatisfactory in the following aspects: comprehensive reporting of financial support (1.9%), provision of included and excluded lists of studies (22.8%), inclusion of grey literature (27.2%), and inclusion of protocols (32.9%). The 126 non-Cochrane meta-analyses had poor performance on almost all the methodological items. Non-Cochrane meta-analyses focused on nonpharmacologic treatments were more likely to consider scientific quality of included studies when making conclusions. The 32 Cochrane meta-analyses generally had good methodological quality except for comprehensive reporting of the sources of support. These results highlight the need for cautious interpretation of these meta-analyses, especially among physicians and policy makers when guidelines are formulated. Future meta-analyses should pay attention to improving these methodological aspects. ©2016 Wiley Periodicals, Inc.

NextGen Future Safety Assessment Game

NASA Technical Reports Server (NTRS)

Ancel, Ersin; Gheorghe, Adian; Jones, Sharon Monica

2010-01-01

The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

NextGen Future Safety Assessment Game

NASA Technical Reports Server (NTRS)

Ancel, Ersin; Gheorghe, Adrian; Jones, Sharon Monica

2011-01-01

The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

Genome and proteome annotation: organization, interpretation and integration

PubMed Central

Reeves, Gabrielle A.; Talavera, David; Thornton, Janet M.

2008-01-01

Recent years have seen a huge increase in the generation of genomic and proteomic data. This has been due to improvements in current biological methodologies, the development of new experimental techniques and the use of computers as support tools. All these raw data are useless if they cannot be properly analysed, annotated, stored and displayed. Consequently, a vast number of resources have been created to present the data to the wider community. Annotation tools and databases provide the means to disseminate these data and to comprehend their biological importance. This review examines the various aspects of annotation: type, methodology and availability. Moreover, it puts a special interest on novel annotation fields, such as that of phenotypes, and highlights the recent efforts focused on the integrating annotations. PMID:19019817

Development of methodologies for the estimation of thermal properties associated with aerospace vehicles

NASA Technical Reports Server (NTRS)

Scott, Elaine P.

1993-01-01

Thermal stress analyses are an important aspect in the development of aerospace vehicles such as the National Aero-Space Plane (NASP) and the High-Speed Civil Transport (HSCT) at NASA-LaRC. These analyses require knowledge of the temperature within the structures which consequently necessitates the need for thermal property data. The initial goal of this research effort was to develop a methodology for the estimation of thermal properties of aerospace structural materials at room temperature and to develop a procedure to optimize the estimation process. The estimation procedure was implemented utilizing a general purpose finite element code. In addition, an optimization procedure was developed and implemented to determine critical experimental parameters to optimize the estimation procedure. Finally, preliminary experiments were conducted at the Aircraft Structures Branch (ASB) laboratory.

Development of methodologies for the estimation of thermal properties associated with aerospace vehicles

NASA Astrophysics Data System (ADS)

Scott, Elaine P.

1993-12-01

Thermal stress analyses are an important aspect in the development of aerospace vehicles such as the National Aero-Space Plane (NASP) and the High-Speed Civil Transport (HSCT) at NASA-LaRC. These analyses require knowledge of the temperature within the structures which consequently necessitates the need for thermal property data. The initial goal of this research effort was to develop a methodology for the estimation of thermal properties of aerospace structural materials at room temperature and to develop a procedure to optimize the estimation process. The estimation procedure was implemented utilizing a general purpose finite element code. In addition, an optimization procedure was developed and implemented to determine critical experimental parameters to optimize the estimation procedure. Finally, preliminary experiments were conducted at the Aircraft Structures Branch (ASB) laboratory.

The temporal structure of pollution levels in developed cities.

PubMed

Barrigón Morillas, Juan Miguel; Ortiz-Caraballo, Carmen; Prieto Gajardo, Carlos

2015-06-01

Currently, the need for mobility can cause significant pollution levels in cities, with important effects on health and quality of life. Any approach to the study of urban pollution and its effects requires an analysis of spatial distribution and temporal variability. It is a crucial dilemma to obtain proven methodologies that allow an increase in the quality of the prediction and the saving of resources in the spatial and temporal sampling. This work proposes a new analytical methodology in the study of temporal structure. As a result, a model for estimating annual levels of urban traffic noise was proposed. The average errors are less than one decibel in all acoustics indicators. A new working methodology of urban noise has begun. Additionally, a general application can be found for the study of the impacts of pollution associated with traffic, with implications for urban design and possibly in economic and sociological aspects. Copyright © 2015 Elsevier B.V. All rights reserved.

Treatment resistance and psychodynamic psychiatry: concepts psychiatry needs from psychoanalysis.

PubMed

Plakun, Eric

2012-06-01

Over the last 30 years psychiatry and psychoanalysis have moved in substantially divergent directions. Psychiatry has become rich in methodology but conceptually limited, with a drift toward biological reductionism. Psychoanalysis has remained relatively limited in methodology, but conceptually rich. The rich methodology of psychiatry has led to major contributions in discovering gene by environment interactions, the importance of early adversity, and to recognition of the serious problem posed by treatment resistance. However, psychiatry's biologically reductionistic conceptual focus interferes with the development of a nuanced clinical perspective based on emerging knowledge that might help more treatment resistant patients become treatment responders. This article argues that recognition of the problem of treatment resistance in psychiatry creates a need for it to reconnect with the conceptual richness of psychoanalysis in order to improve patient care. Psychodynamic psychiatry is defined as the relevant intersection of psychiatry and psychoanalysis where this reconnection can occur. I will suggest selected aspects of psychoanalysis that are especially relevant to psychiatry in improving outcomes in work with treatment resistant patients.

Associated with aerospace vehicles development of methodologies for the estimation of thermal properties

NASA Technical Reports Server (NTRS)

Scott, Elaine P.

1994-01-01

Thermal stress analyses are an important aspect in the development of aerospace vehicles at NASA-LaRC. These analyses require knowledge of the temperature distributions within the vehicle structures which consequently necessitates the need for accurate thermal property data. The overall goal of this ongoing research effort is to develop methodologies for the estimation of the thermal property data needed to describe the temperature responses of these complex structures. The research strategy undertaken utilizes a building block approach. The idea here is to first focus on the development of property estimation methodologies for relatively simple conditions, such as isotropic materials at constant temperatures, and then systematically modify the technique for the analysis of more and more complex systems, such as anisotropic multi-component systems. The estimation methodology utilized is a statistically based method which incorporates experimental data and a mathematical model of the system. Several aspects of this overall research effort were investigated during the time of the ASEE summer program. One important aspect involved the calibration of the estimation procedure for the estimation of the thermal properties through the thickness of a standard material. Transient experiments were conducted using a Pyrex standard at various temperatures, and then the thermal properties (thermal conductivity and volumetric heat capacity) were estimated at each temperature. Confidence regions for the estimated values were also determined. These results were then compared to documented values. Another set of experimental tests were conducted on carbon composite samples at different temperatures. Again, the thermal properties were estimated for each temperature, and the results were compared with values obtained using another technique. In both sets of experiments, a 10-15 percent off-set between the estimated values and the previously determined values was found. Another effort was related to the development of the experimental techniques. Initial experiments required a resistance heater placed between two samples. The design was modified such that the heater was placed on the surface of only one sample, as would be necessary in the analysis of built up structures. Experiments using the modified technique were conducted on the composite sample used previously at different temperatures. The results were within 5 percent of those found using two samples. Finally, an initial heat transfer analysis, including conduction, convection and radiation components, was completed on a titanium sandwich structural sample. Experiments utilizing this sample are currently being designed and will be used to first estimate the material's effective thermal conductivity and later to determine the properties associated with each individual heat transfer component.

Threads that guide or ties that bind: William Kirby and the essentialism story.

PubMed

Varma, Charissa S

2009-01-01

Nineteenth-century British entomologist William Kirby is best known for his generic division of bees based on tongues and his vigorous defence of natural theology. Focusing on these aspects of Kirby's work has lead many current scholars to characterise Kirby as an "essentialist." As a result of this characterisation, many important aspects of his work, Monographia Apum Angliae (1802) have been over-looked or misunderstood. Kirby's religious devotion, for example, have lead some scholars to assume Kirby used the term "type" for connecting an ontological assumption about essences with a creationist assumption about species fixity, which I argue conceals a variety of ways Kirby employed the term. Also, Kirby frequently cautioned against organising a classification system exclusively by what he called "analytic reasoning," a style of reasoning 20th century scholars often associate with Aristotelian logic of division. I argue that Kirby's critique of analytic reasoning brought the virtues of his own methodological agenda into sharp relief. Kirby used familiar metaphors in the natural history literature--Ariadne's thread, the Eleusinian mysteries, and Bacon's bee and spider metaphors--to emphasise the virtues of building tradition and cooperation in the goals and methodological practices of 19th century British naturalists.

The Role of DNA Methylation in Cardiovascular Risk and Disease: Methodological Aspects, Study Design, and Data Analysis for Epidemiological Studies.

PubMed

Zhong, Jia; Agha, Golareh; Baccarelli, Andrea A

2016-01-08

Epidemiological studies have demonstrated that genetic, environmental, behavioral, and clinical factors contribute to cardiovascular disease development. How these risk factors interact at the cellular level to cause cardiovascular disease is not well known. Epigenetic epidemiology enables researchers to explore critical links between genomic coding, modifiable exposures, and manifestation of disease phenotype. One epigenetic link, DNA methylation, is potentially an important mechanism underlying these associations. In the past decade, there has been a significant increase in the number of epidemiological studies investigating cardiovascular risk factors and outcomes in relation to DNA methylation, but many gaps remain in our understanding of the underlying cause and biological implications. In this review, we provide a brief overview of the biology and mechanisms of DNA methylation and its role in cardiovascular disease. In addition, we summarize the current evidence base in epigenetic epidemiology studies relevant to cardiovascular health and disease and discuss the limitations, challenges, and future directions of the field. Finally, we provide guidelines for well-designed epigenetic epidemiology studies, with particular focus on methodological aspects, study design, and analytical challenges. © 2016 American Heart Association, Inc.

Posthumanism as Research Methodology: Inquiry in the Anthropocene

ERIC Educational Resources Information Center

Ulmer, Jasmine B.

2017-01-01

The posthuman turn has radically--and rapidly--shifted what is possible in research methodology. In response, my aim in this conceptual paper is to suggest entry points into posthuman educational research methodology. I outline aspects of posthumanism while recognizing its multiplicity: there are many posthumanisms and each offers different…

[Methodological aspects of a study of medical service satisfaction in patients with borderline mental disorders].

PubMed

Malygin, Ya V; Tsygankov, B D

The authors discussed a methodology of the study of medical service satisfaction and it's factors: moment of assessment, methodology of data collection, format of data, bench-marking, principles of inclusion of questions into a questionnaire, organizing and frequency of conducting studies.

ECSIN's methodological approach for hazard evaluation of engineered nanomaterials

NASA Astrophysics Data System (ADS)

Bregoli, Lisa; Benetti, Federico; Venturini, Marco; Sabbioni, Enrico

2013-04-01

The increasing production volumes and commercialization of engineered nanomaterials (ENM), together with data on their higher biological reactivity when compared to bulk counterpart and ability to cross biological barriers, have caused concerns about their potential impacts on the health and safety of both humans and the environment. A multidisciplinary component of the scientific community has been called to evaluate the real risks associated with the use of products containing ENM, and is today in the process of developing specific definitions and testing strategies for nanomaterials. At ECSIN we are developing an integrated multidisciplinary methodological approach for the evaluation of the biological effects of ENM on the environment and human health. While our testing strategy agrees with the most widely advanced line of work at the European level, the choice of methods and optimization of protocols is made with an extended treatment of details. Our attention to the methodological and technical details is based on the acknowledgment that the innovative characteristics of matter at the nano-size range may influence the existing testing methods in a partially unpredictable manner, an aspect which is frequently recognized at the discussion level but oftentimes disregarded at the laboratory bench level. This work outlines the most important steps of our testing approach. In particular, each step will be briefly discussed in terms of potential technical and methodological pitfalls that we have encountered, and which are often ignored in nanotoxicology research. The final aim is to draw attention to the need of preliminary studies in developing reliable tests, a crucial aspect to confirm the suitability of the chosen analytical and toxicological methods to be used for the specific tested nanoparticle, and to express the idea that in nanotoxicology,"devil is in the detail".

Dealing with Time in Health Economic Evaluation: Methodological Issues and Recommendations for Practice.

PubMed

O'Mahony, James F; Newall, Anthony T; van Rosmalen, Joost

2015-12-01

Time is an important aspect of health economic evaluation, as the timing and duration of clinical events, healthcare interventions and their consequences all affect estimated costs and effects. These issues should be reflected in the design of health economic models. This article considers three important aspects of time in modelling: (1) which cohorts to simulate and how far into the future to extend the analysis; (2) the simulation of time, including the difference between discrete-time and continuous-time models, cycle lengths, and converting rates and probabilities; and (3) discounting future costs and effects to their present values. We provide a methodological overview of these issues and make recommendations to help inform both the conduct of cost-effectiveness analyses and the interpretation of their results. For choosing which cohorts to simulate and how many, we suggest analysts carefully assess potential reasons for variation in cost effectiveness between cohorts and the feasibility of subgroup-specific recommendations. For the simulation of time, we recommend using short cycles or continuous-time models to avoid biases and the need for half-cycle corrections, and provide advice on the correct conversion of transition probabilities in state transition models. Finally, for discounting, analysts should not only follow current guidance and report how discounting was conducted, especially in the case of differential discounting, but also seek to develop an understanding of its rationale. Our overall recommendations are that analysts explicitly state and justify their modelling choices regarding time and consider how alternative choices may impact on results.

Client experiences of motivational interviewing: An interpersonal process recall study.

PubMed

Jones, Sarah A; Latchford, Gary; Tober, Gillian

2016-03-01

To explore clients' experience of the therapy process in motivational interviewing (MI) for alcohol abuse. A qualitative study using grounded theory. Interviews with nine clients were conducted using interpersonal process recall (IPR), a methodology which utilizes a video recording as a cue to aid memory recall. Clients watched a videotape of their MI session and were asked to identify and describe the important moments in the therapy session. The transcribed interviews were then analysed using grounded theory. A single session of MI is seen by the clients in this study as a complex interpersonal interaction between client and therapist, which impacts on the client's cognitive and affective intrapersonal processes. The themes which emerged partly confirm processes of MI previously hypothesized to be important, but also highlight the importance of factors common to all therapeutic approaches. The aspects of therapy which clients in this study felt were important are similar to those hypothesized to underlie the effectiveness of MI, including a non-confrontational approach, affirmation, and developing discrepancies between beliefs and behaviour. These were embedded in aspects common to all therapies, including the qualities of the therapist and the therapeutic relationship. Client's perspectives on therapeutic processes are an important area of research, and IPR is a particularly suitable method. © 2015 The British Psychological Society.

Probiotics production and alternative encapsulation methodologies to improve their viabilities under adverse environmental conditions.

PubMed

Coghetto, Chaline Caren; Brinques, Graziela Brusch; Ayub, Marco Antônio Záchia

2016-12-01

Probiotic products are dietary supplements containing live microorganisms producing beneficial health effects on the host by improving intestinal balance and nutrient absorption. Among probiotic microorganisms, those classified as lactic acid bacteria are of major importance to the food and feed industries. Probiotic cells can be produced using alternative carbon and nitrogen sources, such as agroindustrial residues, at the same time contributing to reduce process costs. On the other hand, the survival of probiotic cells in formulated food products, as well as in the host gut, is an essential nutritional aspect concerning health benefits. Therefore, several cell microencapsulation techniques have been investigated as a way to improve cell viability and survival under adverse environmental conditions, such as the gastrointestinal milieu of hosts. In this review, different aspects of probiotic cells and technologies of their related products are discussed, including formulation of culture media, and aspects of cell microencapsulation techniques required to improve their survival in the host.

Metal ions in neurology and psychiatry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gabay, S.; Harris, J.; Ho, B.T.

1985-01-01

This book consists of five sections, each containing several papers. The section titles are: CNS Development and Aging, Clinically Related Aspects of Trace Elements, Neurochemical Aspects, Neurotoxicity and Neuropathology, and Methodology and Application.

Shoulder-to-Shoulder Research "with" Children: Methodological and Ethical Considerations

ERIC Educational Resources Information Center

Griffin, Krista M.; Lahman, Maria K. E.; Opitz, Michael F.

2016-01-01

This paper presents a methodological study with children where two different interview methods were utilized: the "walk-around" (a form of mobile interview) and the "shoulder-to-shoulder." The paper reviews the methodological aspects of the study then provides a brief review of the history of methods employed in research with…

Diffraction or Reflection? Sketching the Contours of Two Methodologies in Educational Research

ERIC Educational Resources Information Center

Bozalek, Vivienne; Zembylas, Michalinos

2017-01-01

Internationally, an interest is emerging in a growing body of work on what has become known as "diffractive methodologies" drawing attention to ontological aspects of research. Diffractive methodologies have largely been developed in response to a dissatisfaction with practices of "reflexivity", which are seen to be grounded in…

INHALATION EXPOSURE-RESPONSE METHODOLOGY

EPA Science Inventory

The Inhalation Exposure-Response Analysis Methodology Document is expected to provide guidance on the development of the basic toxicological foundations for deriving reference values for human health effects, focusing on the hazard identification and dose-response aspects of the ...

Critical appraisal of published economic evaluations of home care for the elderly.

PubMed

Ramos, Maria Lucia Teixeira; Ferraz, Marcos Bosi; Sesso, Ricardo

2004-01-01

The goal of the study was to appraise the economic evaluations published between 1980 and 2004 of "home care" for the elderly, focusing on the methodological aspects. MEDLINE was searched to identify and assess economic evaluations (defined as an analysis comparing two or more strategies, involving the assessment of both costs and consequences) related to "home care" exclusively for the elderly (65 years or more) and to critically appraise the methodology using five accepted principles used worldwide for conducting economic evaluations. Twenty-four economic evaluations of "home care" for the elderly were identified and the articles were assessed. All five principles were satisfactorily addressed in two studies (8.3%), four principles in four studies (16.7%), three principles in five studies (20.8%), two principles in eight studies (33.3%) and only one principle in five studies (20.8%). A disparity in the methodology of writing economic evaluations compromises the comparisons among outcomes and lately jeopardizes decisions on the choice of the most appropriate healthcare interventions. The methodological principles represent important guidelines but the discussion of the context of the economic evaluation and the special characteristics of some services and populations should be considered for the appropriate use of economic evaluations.

The Methodology for Developing Mobile Agent Application for Ubiquitous Environment

NASA Astrophysics Data System (ADS)

Matsuzaki, Kazutaka; Yoshioka, Nobukazu; Honiden, Shinichi

A methodology which enables a flexible and reusable development of mobile agent application to a mobility aware indoor environment is provided in this study. The methodology is named Workflow-awareness model based on a concept of a pair of mobile agents cooperating to perform a given task. A monolithic mobile agent application with numerous concerns in a mobility aware setting is divided into a master agent (MA) and a shadow agent (SA) according to a type of tasks. The MA executes a main application logic which includes monitoring a user's physical movement and coordinating various services. The SA performs additional tasks depending on environments to aid the MA in achieving efficient execution without losing application logic. "Workflow-awareness (WFA)" means that the SA knows the MA's execution state transition so that the SA can provide a proper task at a proper timing. A prototype implementation of the methodology is done with a practical use of AspectJ. AspectJ is used to automate WFA by weaving communication modules to both MA and SA. Usefulness of this methodology concerning its efficiency and software engineering aspects are analyzed. As for the effectiveness, the overhead of WFA is relatively small to the whole expenditure time. And from the view of the software engineering, WFA is possible to provide a mechanism to deploy one application in various situations.

Are consumer surveys valuable as a service improvement tool in health services? A critical appraisal.

PubMed

Patwardhan, Anjali; Patwardhan, Prakash

2009-01-01

In the recent climate of consumerism and consumer focused care, health and social care needs to be more responsive than ever before. Consumer needs and preferences can be elicited with accepted validity and reliability only by strict methodological control, customerisation of the questionnaire and skilled interpretation. To construct, conduct, interpret and implement improved service provision, requires a trained work force and infrastructure. This article aims to appraise various aspects of consumer surveys and to assess their value as effective service improvement tools. The customer is the sole reason organisations exist. Consumer surveys are used worldwide as service and quality of care improvement tools by all types of service providers including health service providers. The article critically appraises the value of consumer surveys as service improvement tools in health services tool and its future applications. No one type of survey is the best or ideal. The key is the selection of the correct survey methodology, unique and customised for the particular type/aspect of care being evaluated. The method used should reflect the importance of the information required. Methodological rigor is essential for the effectiveness of consumer surveys as service improvement tools. Unfortunately so far there is no universal consensus on superiority of one particular methodology over another or any benefit of one specific methodology in a given situation. More training and some dedicated resource allocation is required to develop consumer surveys. More research is needed to develop specific survey methodology and evaluation techniques for improved validity and reliability of the surveys as service improvement tools. Measurement of consumer preferences/priorities, evaluation of services and key performance scores, is not easy. Consumer surveys seem impressive tools as they provide the customer a voice for change or modification. However, from a scientific point-of-view their credibility in service improvement in terms of reproducibility, reliability and validity, has remained debatable. This artcile is a critical appraisal of the value of consumer surveys as a service improvement tool in health services--a lesson which needs to be learnt.

Engineering and programming manual: Two-dimensional kinetic reference computer program (TDK)

NASA Technical Reports Server (NTRS)

Nickerson, G. R.; Dang, L. D.; Coats, D. E.

1985-01-01

The Two Dimensional Kinetics (TDK) computer program is a primary tool in applying the JANNAF liquid rocket thrust chamber performance prediction methodology. The development of a methodology that includes all aspects of rocket engine performance from analytical calculation to test measurements, that is physically accurate and consistent, and that serves as an industry and government reference is presented. Recent interest in rocket engines that operate at high expansion ratio, such as most Orbit Transfer Vehicle (OTV) engine designs, has required an extension of the analytical methods used by the TDK computer program. Thus, the version of TDK that is described in this manual is in many respects different from the 1973 version of the program. This new material reflects the new capabilities of the TDK computer program, the most important of which are described.

A method to perform a fast fourier transform with primitive image transformations.

PubMed

Sheridan, Phil

2007-05-01

The Fourier transform is one of the most important transformations in image processing. A major component of this influence comes from the ability to implement it efficiently on a digital computer. This paper describes a new methodology to perform a fast Fourier transform (FFT). This methodology emerges from considerations of the natural physical constraints imposed by image capture devices (camera/eye). The novel aspects of the specific FFT method described include: 1) a bit-wise reversal re-grouping operation of the conventional FFT is replaced by the use of lossless image rotation and scaling and 2) the usual arithmetic operations of complex multiplication are replaced with integer addition. The significance of the FFT presented in this paper is introduced by extending a discrete and finite image algebra, named Spiral Honeycomb Image Algebra (SHIA), to a continuous version, named SHIAC.

Integrating ecosystem studies: A Bayesian comparison of hypotheses

USGS Publications Warehouse

Adkison, Milo D.; Ballachey, Brenda E.; Bodkin, James L.; Holland-Bartels, Leslie E.; Funk, F.; Quinn, T.J.; Heifetz, J.; Ianelli, J.N.; Powers, J.E.; Schweigert, J.F.; Sullivan, P.J.; Zhang, C.-I.

1998-01-01

Ecosystem studies are difficult to interpret because of the complexity and number of pathways that may affect a phenomenon of interest. It is not possible to study all aspects of a problem; thus subjective judgment is required to weigh what has been observed in the context of components that were not studied but may have been important. This subjective judgment is usually a poorly documented and ad hoc addendum to a statistical analysis of the data. We present a Bayesian methodology for documenting, quantifying, and incorporating these necessary subjective elements into an ecosystem study. The end product of this methodology is the probability of each of the competing hypotheses. As an example, this method is applied to an ecosystem study designed to discriminate among competing hypotheses for a low abundance of sea otters at a previously oiled site in Prince William Sound, Alaska.

A survey of computational aerodynamics in the United States

NASA Technical Reports Server (NTRS)

Gessow, A.; Morris, D. J.

1977-01-01

Programs in theoretical and computational aerodynamics in the United States are described. Those aspects of programs that relate to aeronautics are detailed. The role of analysis at various levels of sophistication is discussed as well as the inverse solution techniques that are of primary importance in design methodology. The research is divided into the broad categories of application for boundary layer flow, Navier-Stokes turbulence modeling, internal flows, two-dimensional configurations, subsonic and supersonic aircraft, transonic aircraft, and the space shuttle. A survey of representative work in each area is presented.

An alternative to the neoliberal model in health: the case of Venezuela.

PubMed

Feo, Oscar; Siqueira, Carlos Eduardo

2004-01-01

The authors present a synthesis of the proposals put forth by the health sector of Venezuela during the framing of the new Venezuelan Constitution. They summarize the background to the National Constituent Assembly and the legal framework typical of the health sector at that time, identify the methodological aspects that substantiated the health topics included in the new Constitution, and analyze the articles that shape the current constitutional health framework in Venezuela, summarizing their most important features and comparing them with neoliberal health proposals.

Economic evaluation of health promotion interventions for older people: do applied economic studies meet the methodological challenges?

PubMed

Huter, Kai; Dubas-Jakóbczyk, Katarzyna; Kocot, Ewa; Kissimova-Skarbek, Katarzyna; Rothgang, Heinz

2018-01-01

In the light of demographic developments health promotion interventions for older people are gaining importance. In addition to methodological challenges arising from the economic evaluation of health promotion interventions in general, there are specific methodological problems for the particular target group of older people. There are especially four main methodological challenges that are discussed in the literature. They concern measurement and valuation of informal caregiving, accounting for productivity costs, effects of unrelated cost in added life years and the inclusion of 'beyond-health' benefits. This paper focuses on the question whether and to what extent specific methodological requirements are actually met in applied health economic evaluations. Following a systematic review of pertinent health economic evaluations, the included studies are analysed on the basis of four assessment criteria that are derived from methodological debates on the economic evaluation of health promotion interventions in general and economic evaluations targeting older people in particular. Of the 37 studies included in the systematic review, only very few include cost and outcome categories discussed as being of specific relevance to the assessment of health promotion interventions for older people. The few studies that consider these aspects use very heterogeneous methods, thus there is no common methodological standard. There is a strong need for the development of guidelines to achieve better comparability and to include cost categories and outcomes that are relevant for older people. Disregarding these methodological obstacles could implicitly lead to discrimination against the elderly in terms of health promotion and disease prevention and, hence, an age-based rationing of public health care.

Anthropology, Participation, and the Democratization of Knowledge: Participatory Research Using Video with Youth Living in Extreme Poverty

ERIC Educational Resources Information Center

Batallan, Graciela; Dente, Liliana; Ritta, Loreley

2017-01-01

This article aims to open up a debate on methodological aspects of ethnographic research, arguing for the legitimacy of the information produced in a research "taller" or workshop using a participatory methodology and video production as a methodological tool. Based on the theoretical foundations and analysis of a "taller"…

A theoretical and experimental investigation of propeller performance methodologies

NASA Technical Reports Server (NTRS)

Korkan, K. D.; Gregorek, G. M.; Mikkelson, D. C.

1980-01-01

This paper briefly covers aspects related to propeller performance by means of a review of propeller methodologies; presentation of wind tunnel propeller performance data taken in the NASA Lewis Research Center 10 x 10 wind tunnel; discussion of the predominent limitations of existing propeller performance methodologies; and a brief review of airfoil developments appropriate for propeller applications.

Protein-Protein Interface and Disease: Perspective from Biomolecular Networks.

PubMed

Hu, Guang; Xiao, Fei; Li, Yuqian; Li, Yuan; Vongsangnak, Wanwipa

Protein-protein interactions are involved in many important biological processes and molecular mechanisms of disease association. Structural studies of interfacial residues in protein complexes provide information on protein-protein interactions. Characterizing protein-protein interfaces, including binding sites and allosteric changes, thus pose an imminent challenge. With special focus on protein complexes, approaches based on network theory are proposed to meet this challenge. In this review we pay attention to protein-protein interfaces from the perspective of biomolecular networks and their roles in disease. We first describe the different roles of protein complexes in disease through several structural aspects of interfaces. We then discuss some recent advances in predicting hot spots and communication pathway analysis in terms of amino acid networks. Finally, we highlight possible future aspects of this area with respect to both methodology development and applications for disease treatment.

Review of ship slamming loads and responses

NASA Astrophysics Data System (ADS)

Wang, Shan; Guedes Soares, C.

2017-12-01

The paper presents an overview of studies of slamming on ship structures. This work focuses on the hull slamming, which is one of the most important types of slamming problems to be considered in the ship design process and the assessment of the ship safety. There are three main research aspects related to the hull slamming phenomenon, a) where and how often a slamming event occurs, b) slamming load prediction and c) structural response due to slamming loads. The approaches used in each aspect are reviewed and commented, together with the presentation of some typical results. The methodology, which combines the seakeeping analysis and slamming load prediction, is discussed for the global analysis of the hull slamming of a ship in waves. Some physical phenomena during the slamming event are discussed also. Recommendations for the future research and developments are made.

Uncertainty, the Overbearing Lived Experience of the Elderly People Undergoing Hemodialysis: A Qualitative Study.

PubMed

Sahaf, Robab; Sadat Ilali, Ehteram; Peyrovi, Hamid; Akbari Kamrani, Ahmad Ali; Spahbodi, Fatemeh

2017-01-01

The chronic kidney disease is a major health concern. The number of the elderly people with chronic renal failure has increased across the world. Dialysis is an appropriate therapy for the elderly, but it involves certain challenges. The present paper reports uncertainty as part of the elderly experiences of living with hemodialysis. This qualitative study applied Max van Manen interpretative phenomenological analysis to explain and explore experiences of the elderly with hemodialysis. Given the study inclusion criteria, data were collected using in-depth unstructured interviews with nine elderly undergoing hemodialysis, and then analyzed according to Van Manen 6-stage methodological approach. One of the most important findings emerging in the main study was "uncertainty", which can be important and noteworthy, given other aspects of the elderly life (loneliness, despair, comorbidity of diseases, disability, and mental and psychosocial problems). Uncertainty about the future is the most psychological concerns of people undergoing hemodialysis. The results obtained are indicative of the importance of paying attention to a major aspect in the life of the elderly undergoing hemodialysis, uncertainty. A positive outlook can be created in the elderly through education and increased knowledge about the disease, treatment and complications.

Interpersonal and systemic aspects of emotional abuse at work: the target's perspective.

PubMed

Keashly, L

2001-06-01

The most frequent form of workplace aggression is not physical, it is emotional and psychological in nature. Known by many names, emotional abuse at work is rapidly becoming recognized as pervasive and costly both in individual and organizational terms. Most of the research to date on emotional abuse at work has utilized survey and other quantitative methodologies in an effort to document the presence, prevalence, and impact of these behaviors. However, these methodologies are based on researchers' definitions and theories of what constitutes emotional abuse rather than on the meaning given to these experiences by the targets of these behaviors. A thorough understanding of this phenomenon requires a scholarly appreciation of the target's experience. Taking "feeling abused" as the criterion variable, this study examined target's experiences based on interviews with people who self-identifed as having experienced difficulties with a boss, coworker, or subordinate. The interpersonal aspects of emotional abuse focused on the nature of behaviors exhibited and the respondents' labeling of their experience. Consistent with elements of researchers' definitions, behaviors were defined as abusive when they were repetitive, resulted in injury or harm to target, and were experienced as a lack of recognition of the individual's integrity. Judgments of violation of standards of conduct and unsolicited nature of the behaviors were also related to respondents' experiences. Relative power differential was also an important element. However, contrary to researchers' definitions, actor intent was not central in defining the experience as abusive. The systemic aspect of emotional abuse was illustrated in the nature of organizational responding to concerns raised by respondents. These responses were of critical importance in respondents' labeling of their experiences as abusive. The focus on the meaning of the behaviors for the respondents provides an enriched picture of key definitional elements. Implications of the findings for future research are discussed.

Methodologies and systems for heterogeneous concurrent computing

NASA Technical Reports Server (NTRS)

Sunderam, V. S.

1994-01-01

Heterogeneous concurrent computing is gaining increasing acceptance as an alternative or complementary paradigm to multiprocessor-based parallel processing as well as to conventional supercomputing. While algorithmic and programming aspects of heterogeneous concurrent computing are similar to their parallel processing counterparts, system issues, partitioning and scheduling, and performance aspects are significantly different. In this paper, we discuss critical design and implementation issues in heterogeneous concurrent computing, and describe techniques for enhancing its effectiveness. In particular, we highlight the system level infrastructures that are required, aspects of parallel algorithm development that most affect performance, system capabilities and limitations, and tools and methodologies for effective computing in heterogeneous networked environments. We also present recent developments and experiences in the context of the PVM system and comment on ongoing and future work.

A global view of undergraduate education in pharmacovigilance.

PubMed

Hartman, Jenny; Härmark, Linda; van Puijenbroek, Eugène

2017-07-01

The aim of this study was to gain insight in current pharmacovigilance educational activities and to gather information on which topics should be included in the undergraduate pharmacovigilance core curriculum. A web-based questionnaire was carried out containing 45 questions divided over four sections between 28 October 2014 and 31 January 2015. Potential participants working in pharmacovigilance and/or providing training in this field were invited via email and a widespread web link and snowball sampling was used to recruit additional participants. The questionnaire was filled out by 307 respondents from 88 different countries with a response rate of 29.3% for the email invitation and an unknown rate for the web link. Respondents were mainly pharmacists and physicians. Currently, lectures are the largest proportion of educational activities and all healthcare profession curricula have a mode of 2 h as number of contact hours per course. Respondents rated clinical aspects as the most important subdomain to be included in the core curriculum with prevention of adverse drug reactions as the most important subtopic. This was followed by communication aspects between parties, with communication between regulatory authorities and healthcare professionals, methodological aspects with causality assessment, and regulatory aspects with benefit-risk assessment. This is similar to subjects addressed in current educational activities with little difference between medical and pharmacy curricula. This study gave a good general impression in current educational activities and the respondents' needs and wishes for future activities worldwide, which both will be used for the development of the undergraduate pharmacovigilance core curriculum.

Charles Darwin and Evolution: Illustrating Human Aspects of Science

NASA Astrophysics Data System (ADS)

Kampourakis, Kostas; McComas, William F.

2010-06-01

Recently, the nature of science (NOS) has become recognized as an important element within the K-12 science curriculum. Despite differences in the ultimate lists of recommended aspects, a consensus is emerging on what specific NOS elements should be the focus of science instruction and inform textbook writers and curriculum developers. In this article, we suggest a contextualized, explicit approach addressing one core NOS aspect: the human aspects of science that include the domains of creativity, social influences and subjectivity. To illustrate these ideas, we have focused on Charles Darwin, a scientist whose life, work and thought processes were particularly well recorded at the time and analyzed by scholars in the succeeding years. Historical facts are discussed and linked to core NOS ideas. Creativity is illustrated through the analogies between the struggle for existence in human societies and in nature, between artificial and natural selection, and between the division of labor in human societies and in nature. Social influences are represented by Darwin’s aversion of criticism of various kinds and by his response to the methodological requirements of the science of that time. Finally, subjectivity is discussed through Darwin’s development of a unique but incorrect source for the origin of variations within species.

Computer-Aided Diagnosis Systems for Lung Cancer: Challenges and Methodologies

PubMed Central

El-Baz, Ayman; Beache, Garth M.; Gimel'farb, Georgy; Suzuki, Kenji; Okada, Kazunori; Elnakib, Ahmed; Soliman, Ahmed; Abdollahi, Behnoush

2013-01-01

This paper overviews one of the most important, interesting, and challenging problems in oncology, the problem of lung cancer diagnosis. Developing an effective computer-aided diagnosis (CAD) system for lung cancer is of great clinical importance and can increase the patient's chance of survival. For this reason, CAD systems for lung cancer have been investigated in a huge number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This paper overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. For each technique, various aspects of technical issues, implemented methodologies, training and testing databases, and validation methods, as well as achieved performances, are described. In addition, the paper addresses several challenges that researchers face in each implementation step and outlines the strengths and drawbacks of the existing approaches for lung cancer CAD systems. PMID:23431282

A lifestyle intervention study targeting individuals with low socioeconomic status of different ethnic origins: important aspects for successful implementation.

PubMed

Teuscher, Dorit; Bukman, Andrea J; van Baak, Marleen A; Feskens, Edith J M; Renes, Reint Jan; Meershoek, Agnes

2017-07-25

Evaluation of the implementation process of trials is important, because the way a study is implemented modifies its outcomes. Furthermore, lessons learned during implementation can inform other researchers on factors that play a role when implementing interventions described in research. This study evaluates the implementation of the MetSLIM study, targeting individuals with low socioeconomic status of different ethnic origins. The MetSLIM study was set up to evaluate the effectiveness of a lifestyle programme on waist circumference and other cardio-metabolic risk factors. The objective of this evaluation was to identify components that were essential for the implementation of the MetSLIM study and to inform other researchers on methodological aspects when working with inadequately reached populations in health research. In this evaluation study the experiences of health professionals, study assistants, a community worker and regional research coordinators involved in the MetSLIM study were explored using semi-structured interviews. Questionnaires were used to evaluate participants' satisfaction with the lifestyle intervention. Our analyses show that a flexible recruitment protocol eventually leads to recruitment of sufficient participants; that trust in the recruiter is an important factor in the recruitment of individuals with low socioeconomic status of different ethnic origins; and that health professionals will unavoidably shape the form of intervention activities. Furthermore, our evaluation shows that daily practice and research mutually influence each other and that the results of an intervention are a product of this interaction. Health promotion research would benefit from a perspective that sees intervention activities not as fixed entities but rather as social interaction that can take on numerous forms. Analysing and reporting the implementation process of studies, like in this evaluation, will allow readers to get a detailed view on the appropriateness of the (intended) study design and intervention for the targeted population. Evaluation studies that shed light on the reasons for adaptations, rather than describing them as deviation from the original plan, would point out methodological aspects important for a study's replication. Furthermore, they would show how various factors can influence the implementation, and therewith initiate a learning cycle for the development of future intervention studies. Netherlands Trial Register NTR3721 (since November 27, 2012).

A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes.

PubMed

Mushkudiani, Nino A; Hukkelhoven, Chantal W P M; Hernández, Adrián V; Murray, Gordon D; Choi, Sung C; Maas, Andrew I R; Steyerberg, Ewout W

2008-04-01

To describe the modeling techniques used for early prediction of outcome in traumatic brain injury (TBI) and to identify aspects for potential improvements. We reviewed key methodological aspects of studies published between 1970 and 2005 that proposed a prognostic model for the Glasgow Outcome Scale of TBI based on admission data. We included 31 papers. Twenty-four were single-center studies, and 22 reported on fewer than 500 patients. The median of the number of initially considered predictors was eight, and on average five of these were selected for the prognostic model, generally including age, Glasgow Coma Score (or only motor score), and pupillary reactivity. The most common statistical technique was logistic regression with stepwise selection of predictors. Model performance was often quantified by accuracy rate rather than by more appropriate measures such as the area under the receiver-operating characteristic curve. Model validity was addressed in 15 studies, but mostly used a simple split-sample approach, and external validation was performed in only four studies. Although most models agree on the three most important predictors, many were developed on small sample sizes within single centers and hence lack generalizability. Modeling strategies have to be improved, and include external validation.

The occupational impact of sleep quality and insomnia symptoms.

PubMed

Kucharczyk, Erica R; Morgan, Kevin; Hall, Andrew P

2012-12-01

While the importance of assessing the occupational consequences of insomnia is emphasized in clinical nosologies and research guidelines, there is little consensus on which aspects of occupational performance should be assessed, the most methodologically justifiable measures of insomnia and work performance, and how outcomes should be reported. The present review was designed to summarize and methodologically critique the assessment of those aspects of occupational performance most impacted by (or most frequently associated with) insomnia symptoms. The 30 studies which met the review inclusion criteria broadly addressed six domains of occupational functioning: absenteeism; workplace accidents; productivity; punctuality; job satisfaction and career progression. Collectively, study outcomes support the conclusions that insomnia symptoms: are consistently associated with excess absenteeism; elevate accident risk in the workplace; reduce subjectively experienced workplace productivity (at least in the shorter term); inhibit career progression; and can degrade job satisfaction. Study outcomes do not support the conclusion that people with insomnia are significantly less punctual than other workers. The overall value of the occupational sleep-health literature, however, is limited by a lack of comparability among studies. In particular, there is a clear need to standardize definitions of sleep and occupational outcomes, and to recognize the confounding influence of health variables on occupational performance and sleep. Copyright © 2012 Elsevier Ltd. All rights reserved.

Urban Water Conservation

NASA Astrophysics Data System (ADS)

Moomaw, Ronald L.

According to its abstract, this book attempts ‘an assessment of various water conservation measures aimed at reducing residential water usage.’ Its intent is to develop a research program whose ‘ultimate goal is to engender a conservation ethic among water users and managers and develop a predictable array of conservation methodologies. …’ Professor Flack indeed has presented an excellent assessment of conservation methodologies, but I believe that the proposed research program is too limited.Following a brief introductory chapter, chapter II presents an extensive review of the water conservation literature published in the 1970's and earlier. It and chapter III, which describes Flack's systematic comparison of the technical, economic, and political aspects of each conservation methodology, are the heart of the book. Chapter IV is a brief discussion and analysis of conservation programs (with examples) that a water utility might adopt. Chapter V is essentially a pilot study of methods of assessing political and social feasibility. Finally, a set of recommendations is presented in chapter VI. All in all, this book is a nice blend of literature review and original research that deals with an important issue.

Discourse analysis: A useful methodology for health-care system researches

PubMed Central

Yazdannik, Ahmadreza; Yousefy, Alireza; Mohammadi, Sepideh

2017-01-01

Discourse analysis (DA) is an interdisciplinary field of inquiry and becoming an increasingly popular research strategy for researchers in various disciplines which has been little employed by health-care researchers. The methodology involves a focus on the sociocultural and political context in which text and talk occur. DA adds a linguistic approach to an understanding of the relationship between language and ideology, exploring the way in which theories of reality and relations of power are encoded in such aspects as the syntax, style, and rhetorical devices used in texts. DA is a useful and productive qualitative methodology but has been underutilized within health-care system research. Without a clear understanding of discourse theory and DA it is difficult to comprehend important research findings and impossible to use DA as a research strategy. To redress this deficiency, in this article, represents an introduction to concepts of discourse and DA, DA history, Philosophical background, DA types and analysis strategy. Finally, we discuss how affect to the ideological dimension of such phenomena discourse in health-care system, health beliefs and intra-disciplinary relationship in health-care system. PMID:29296612

Extending methods: using Bourdieu's field analysis to further investigate taste

NASA Astrophysics Data System (ADS)

Schindel Dimick, Alexandra

2015-06-01

In this commentary on Per Anderhag, Per-Olof Wickman and Karim Hamza's article Signs of taste for science, I consider how their study is situated within the concern for the role of science education in the social and cultural production of inequality. Their article provides a finely detailed methodology for analyzing the constitution of taste within science education classrooms. Nevertheless, because the authors' socially situated methodology draws upon Bourdieu's theories, it seems equally important to extend these methods to consider how and why students make particular distinctions within a relational context—a key aspect of Bourdieu's theory of cultural production. By situating the constitution of taste within Bourdieu's field analysis, researchers can explore the ways in which students' tastes and social positionings are established and transformed through time, space, place, and their ability to navigate the field. I describe the process of field analysis in relation to the authors' paper and suggest that combining the authors' methods with a field analysis can provide a strong methodological and analytical framework in which theory and methods combine to create a detailed understanding of students' interest in relation to their context.

Discourse analysis: A useful methodology for health-care system researches.

PubMed

Yazdannik, Ahmadreza; Yousefy, Alireza; Mohammadi, Sepideh

2017-01-01

Discourse analysis (DA) is an interdisciplinary field of inquiry and becoming an increasingly popular research strategy for researchers in various disciplines which has been little employed by health-care researchers. The methodology involves a focus on the sociocultural and political context in which text and talk occur. DA adds a linguistic approach to an understanding of the relationship between language and ideology, exploring the way in which theories of reality and relations of power are encoded in such aspects as the syntax, style, and rhetorical devices used in texts. DA is a useful and productive qualitative methodology but has been underutilized within health-care system research. Without a clear understanding of discourse theory and DA it is difficult to comprehend important research findings and impossible to use DA as a research strategy. To redress this deficiency, in this article, represents an introduction to concepts of discourse and DA, DA history, Philosophical background, DA types and analysis strategy. Finally, we discuss how affect to the ideological dimension of such phenomena discourse in health-care system, health beliefs and intra-disciplinary relationship in health-care system.

Silence and Memories of War: An Autoethnographic Exploration of Family Secrecy.

PubMed

Rober, Peter; Rosenblatt, Paul C

2017-03-01

A personal journey and a scientific challenge, this is an autoethnographic study about my own family's secrecy. I knew my grandfather had been a German prisoner of war during World War II. We all knew. But nobody talked about it. Then one day I decided I wanted to do systematic research on the issue of family secrecy around my grandfather's war experiences. Researching one's own family can be called autoethnography. It could be said that autoethnography is an approach to research that aims to describe and systemically analyze (graphy) personal experience (auto) to understand social and cultural phenomena (ethno). This scientific approach is quite new in the field of family therapy. This study has been an important personal quest, but it also led to important reflections on silences in families, on my own professional development, and on methodological issues concerning autoethnographical research. For one thing, it highlights some of the positive aspects of family secrecy and silences, and invites us-when confronted with family secrecy in clinical practice-to carefully consider the potential destructive and life-giving aspects of the silence. © 2015 Family Process Institute.

Knowledge based system and decision making methodologies in materials selection for aircraft cabin metallic structures

NASA Astrophysics Data System (ADS)

Adhikari, Pashupati Raj

Materials selection processes have been the most important aspects in product design and development. Knowledge-based system (KBS) and some of the methodologies used in the materials selection for the design of aircraft cabin metallic structures are discussed. Overall aircraft weight reduction means substantially less fuel consumption. Part of the solution to this problem is to find a way to reduce overall weight of metallic structures inside the cabin. Among various methodologies of materials selection using Multi Criterion Decision Making (MCDM) techniques, a few of them are demonstrated with examples and the results are compared with those obtained using Ashby's approach in materials selection. Pre-defined constraint values, mainly mechanical properties, are employed as relevant attributes in the process. Aluminum alloys with high strength-to-weight ratio have been second-to-none in most of the aircraft parts manufacturing. Magnesium alloys that are much lighter in weight as alternatives to the Al-alloys currently in use in the structures are tested using the methodologies and ranked results are compared. Each material attribute considered in the design are categorized as benefit and non-benefit attribute. Using Ashby's approach, material indices that are required to be maximized for an optimum performance are determined, and materials are ranked based on the average of consolidated indices ranking. Ranking results are compared for any disparity among the methodologies.

Understanding palliative care on the heart failure care team: an innovative research methodology.

PubMed

Lingard, Lorelei A; McDougall, Allan; Schulz, Valerie; Shadd, Joshua; Marshall, Denise; Strachan, Patricia H; Tait, Glendon R; Arnold, J Malcolm; Kimel, Gil

2013-05-01

There is a growing call to integrate palliative care for patients with advanced heart failure (HF). However, the knowledge to inform integration efforts comes largely from interview and survey research with individual patients and providers. This work has been critically important in raising awareness of the need for integration, but it is insufficient to inform solutions that must be enacted not by isolated individuals but by complex care teams. Research methods are urgently required to support systematic exploration of the experiences of patients with HF, family caregivers, and health care providers as they interact as a care team. To design a research methodology that can support systematic exploration of the experiences of patients with HF, caregivers, and health care providers as they interact as a care team. This article describes in detail a methodology that we have piloted and are currently using in a multisite study of HF care teams. We describe three aspects of the methodology: the theoretical framework, an innovative sampling strategy, and an iterative system of data collection and analysis that incorporates four data sources and four analytical steps. We anticipate that this innovative methodology will support groundbreaking research in both HF care and other team settings in which palliative integration efforts are emerging for patients with advanced nonmalignant disease. Copyright © 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Carbonate pore system evaluation using the velocity-porosity-pressure relationship, digital image analysis, and differential effective medium theory

NASA Astrophysics Data System (ADS)

Lima Neto, Irineu A.; Misságia, Roseane M.; Ceia, Marco A.; Archilha, Nathaly L.; Oliveira, Lucas C.

2014-11-01

Carbonate reservoirs exhibit heterogeneous pore systems and a wide variety of grain types, which affect the rock's elastic properties and the reservoir parameter relationships. To study the Albian carbonates in the Campos Basin, a methodology is proposed to predict the amount of microporosity and the representative aspect ratio of these inclusions. The method assumes three pore-space scales in two representative inclusion scenarios: 1) a macro-mesopore median aspect ratio from the thin-section digital image analysis (DIA) and 2) a microporosity aspect ratio predicted based on the measured P-wave velocities. Through a laboratory analysis of 10 grainstone core samples of the Albian age, the P- and S-wave velocities (Vp and Vs) are evaluated at effective pressures of 0-10 MPa. The analytical theories in the proposed methodology are functions of the aspect ratios from the differential effective medium (DEM) theory, the macro-mesopore system recognized from the DIA, the amount of microporosity determined by the difference between the porosities estimated from laboratorial helium-gas and the thin-section petrographic images, and the P-wave velocities under dry effective pressure conditions. The DIA procedure is applied to estimate the local and global parameters, and the textural implications concerning ultrasonic velocities and image resolution. The macro-mesopore inclusions contribute to stiffer rocks and higher velocities, whereas the microporosity inclusions contribute to softer rocks and lower velocities. We observe a high potential for this methodology, which uses the microporosity aspect ratio inverted from Vp to predict Vs with a good agreement. The results acceptably characterize the Albian grainstones. The representative macro-mesopore aspect ratio is 0.5, and the inverted microporosity aspect ratio ranges from 0.01 to 0.07. The effective pressure induced an effect of slight porosity reduction during the triaxial tests, mainly in the microporosity inclusions, slightly changing the amount and the aspect ratio of the microporosity.

Diurnal variability of regional cloud and clear-sky radiative parameters derived from GOES data. I - Analysis method. II - November 1978 cloud distributions. III - November 1978 radiative parameters

NASA Technical Reports Server (NTRS)

Minnis, P.; Harrison, E. F.

1984-01-01

Cloud cover is one of the most important variables affecting the earth radiation budget (ERB) and, ultimately, the global climate. The present investigation is concerned with several aspects of the effects of extended cloudiness, taking into account hourly visible and infrared data from the Geostationary Operational Environmental Satelite (GOES). A methodology called the hybrid bispectral threshold method is developed to extract regional cloud amounts at three levels in the atmosphere, effective cloud-top temperatures, clear-sky temperature and cloud and clear-sky visible reflectance characteristics from GOES data. The diurnal variations are examined in low, middle, high, and total cloudiness determined with this methodology for November 1978. The bulk, broadband radiative properties of the resultant cloud and clear-sky data are estimated to determine the possible effect of the diurnal variability of regional cloudiness on the interpretation of ERB measurements.

Analytical modeling of helicopter static and dynamic induced velocity in GRASP

NASA Technical Reports Server (NTRS)

Kunz, Donald L.; Hodges, Dewey H.

1987-01-01

The methodology used by the General Rotorcraft Aeromechanical Stability Program (GRASP) to model the characteristics of the flow through a helicopter rotor in hovering or axial flight is described. Since the induced flow plays a significant role in determining the aeroelastic properties of rotorcraft, the computation of the induced flow is an important aspect of the program. Because of the combined finite-element/multibody methodology used as the basis for GRASP, the implementation of induced velocity calculations presented an unusual challenge to the developers. To preserve the modelling flexibility and generality of the code, it was necessary to depart from the traditional methods of computing the induced velocity. This is accomplished by calculating the actuator disc contributions to the rotor loads in a separate element called the air mass element, and then performing the calculations of the aerodynamic forces on individual blade elements within the aeroelastic beam element.

On regulators with a prescribed degree of stability. M.S. Thesis

NASA Technical Reports Server (NTRS)

Ng, P. T. P.

1981-01-01

Several important aspects of the Regulator with a Prescribed Degree of Stability (RPDS) methodology and its applications are considered. The solution of the time varying RPDS problem as well as the characterization of RPDS closed loop eigenstructure properties are obtained. Based on the asymptotic behavior of RPDS root loci, a one step algorithm for designing Regulators with Prescribed Damping Ratio (RPDR) is developed. The robustness properties of RPDS are characterized in terms of the properties of the return difference and the inverse return difference matrices for the RPDS state feedback loop. This class of regulators is found to possess excellent multiloop margins with respect to stability and degree of stability properties. The ability of RPDS design to tolerate changing operating conditions and unmodelled dynamics are illustrated with a multiterminal dc/ac power system example. The output feedback realization of RPDS requires the use of Linear Quadratic Gaussian (LQG) methodology.

Applied Swarm-based medicine: collecting decision trees for patterns of algorithms analysis.

PubMed

Panje, Cédric M; Glatzer, Markus; von Rappard, Joscha; Rothermundt, Christian; Hundsberger, Thomas; Zumstein, Valentin; Plasswilm, Ludwig; Putora, Paul Martin

2017-08-16

The objective consensus methodology has recently been applied in consensus finding in several studies on medical decision-making among clinical experts or guidelines. The main advantages of this method are an automated analysis and comparison of treatment algorithms of the participating centers which can be performed anonymously. Based on the experience from completed consensus analyses, the main steps for the successful implementation of the objective consensus methodology were identified and discussed among the main investigators. The following steps for the successful collection and conversion of decision trees were identified and defined in detail: problem definition, population selection, draft input collection, tree conversion, criteria adaptation, problem re-evaluation, results distribution and refinement, tree finalisation, and analysis. This manuscript provides information on the main steps for successful collection of decision trees and summarizes important aspects at each point of the analysis.

A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism

PubMed Central

Blockley, Nicholas P.; Griffeth, Valerie E. M.; Simon, Aaron B.; Buxton, Richard B.

2013-01-01

The dynamics of the blood oxygenation level-dependent (BOLD) response are dependent on changes in cerebral blood flow, cerebral blood volume and the cerebral metabolic rate of oxygen consumption. Furthermore, the amplitude of the response is dependent on the baseline physiological state, defined by the haematocrit, oxygen extraction fraction and cerebral blood volume. As a result of this complex dependence, the accurate interpretation of BOLD data and robust intersubject comparisons when the baseline physiology is varied are difficult. The calibrated BOLD technique was developed to address these issues. However, the methodology is complex and its full promise has not yet been realised. In this review, the theoretical underpinnings of calibrated BOLD, and issues regarding this theory that are still to be resolved, are discussed. Important aspects of practical implementation are reviewed and reported applications of this methodology are presented. PMID:22945365

Social survey findings on en route noise annoyance issues

NASA Technical Reports Server (NTRS)

Fields, James M.

1990-01-01

Most surveys of residents' reactions to aircraft noise were conducted in the vicinity of airports. The findings in those surveys have supported planning and regulatory actions for the airport noise environment. Now, however, aircraft noise planning and regulations are being considered for a new environment, the en route environment. As policy makers search for bases for public policy in these new noise environments, it is appropriate to ask whether the same scientific evidence which supports airport noise policy can also support en route noise policy. Several aspects of that question are considered. An introduction establishes the scope of the present study and examines alternative study methodologies. Next, the selected study methodology is described and important assumptions are listed. The body of the paper then consists of the findings on en route issues. The final section presents findings on relevant research methods and considers priorities for further research.

Social customer relationship management: taking advantage of Web 2.0 and Big Data technologies.

PubMed

Orenga-Roglá, Sergio; Chalmeta, Ricardo

2016-01-01

The emergence of Web 2.0 and Big Data technologies has allowed a new customer relationship strategy based on interactivity and collaboration called Social Customer Relationship Management (Social CRM) to be created. This enhances customer engagement and satisfaction. The implementation of Social CRM is a complex task that involves different organisational, human and technological aspects. However, there is a lack of methodologies to assist companies in these processes. This paper shows a novel methodology that helps companies to implement Social CRM, taking into account different aspects such as social customer strategy, the Social CRM performance measurement system, the Social CRM business processes, or the Social CRM computer system. The methodology was applied to one company in order to validate and refine it.

San Luis Basin Sustainability Metrics Project: A Methodology for Evaluating Regional Sustainability

EPA Science Inventory

Although there are several scientifically-based sustainability metrics, many are data intensive, difficult to calculate, and fail to capture all aspects of a system. To address these issues, we produced a scientifically-defensible, but straightforward and inexpensive, methodolog...

Changes in the reflectance of ex situ leaves: A methodological approach

NASA Astrophysics Data System (ADS)

Ponzoni, Flavio Jorge; Inoe, Mario Takao

1992-04-01

The main aspects of the interaction between electromagnetic radiation and detached leaves are presented. An experiment with Eucalipto and Araucaria detached leaves is described, including the description of the methodologies utilized in the collection and storage of the reflectance.

Evaluation Methods Sourcebook.

ERIC Educational Resources Information Center

Love, Arnold J., Ed.

The chapters commissioned for this book describe key aspects of evaluation methodology as they are practiced in a Canadian context, providing representative illustrations of recent developments in evaluation methodology as it is currently applied. The following chapters are included: (1) "Program Evaluation with Limited Fiscal and Human…

Risk of bias and methodological issues in randomised controlled trials of acupuncture for knee osteoarthritis: a cross-sectional study

PubMed Central

Lee, Andy H; Zhou, Xu; Kang, Deying; Luo, Yanan; Liu, Jiali; Sun, Xin

2018-01-01

Objective To assess risk of bias and to investigate methodological issues concerning the design, conduct and analysis of randomised controlled trials (RCTs) testing acupuncture for knee osteoarthritis (KOA). Methods PubMed, EMBASE, Cochrane Central Register of Controlled Trials and four major Chinese databases were searched for RCTs that investigated the effect of acupuncture for KOA. The Cochrane tool was used to examine the risk of bias of eligible RCTs. Their methodological details were examined using a standardised and pilot-tested questionnaire of 48 items, together with the association between four predefined factors and important methodological quality indicators. Results A total of 248 RCTs were eligible, of which 39 (15.7%) used computer-generated randomisation sequence. Of the 31 (12.5%) trials that stated the allocation concealment, only one used central randomisation. Twenty-five (10.1%) trials mentioned that their acupuncture procedures were standardised, but only 18 (7.3%) specified how the standardisation was achieved. The great majority of trials (n=233, 94%) stated that blinding was in place, but 204 (87.6%) did not clarify who was blinded. Only 27 (10.9%) trials specified the primary outcome, for which 7 used intention-to-treat analysis. Only 17 (6.9%) trials included details on sample size calculation; none preplanned an interim analysis and associated stopping rule. In total, 46 (18.5%) trials explicitly stated that loss to follow-up occurred, but only 6 (2.4%) provided some information to deal with the issue. No trials prespecified, conducted or reported any subgroup or adjusted analysis for the primary outcome. Conclusion The overall risk of bias was high among published RCTs testing acupuncture for KOA. Methodological limitations were present in many important aspects of design, conduct and analyses. These findings inform the development of evidence-based methodological guidance for future trials assessing the effect of acupuncture for KOA. PMID:29511016

Experiments: Why and How?

PubMed

Hansson, Sven Ove

2016-06-01

An experiment, in the standard scientific sense of the term, is a procedure in which some object of study is subjected to interventions (manipulations) that aim at obtaining a predictable outcome or at least predictable aspects of the outcome. The distinction between an experiment and a non-experimental observation is important since they are tailored to different epistemic needs. Experimentation has its origin in pre-scientific technological experiments that were undertaken in order to find the best technological means to achieve chosen ends. Important parts of the methodological arsenal of modern experimental science can be traced back to this pre-scientific, technological tradition. It is claimed that experimentation involves a unique combination of acting and observing, a combination whose unique epistemological properties have not yet been fully clarified.

Covariance propagation in spectral indices

DOE PAGES

Griffin, P. J.

2015-01-09

In this study, the dosimetry community has a history of using spectral indices to support neutron spectrum characterization and cross section validation efforts. An important aspect to this type of analysis is the proper consideration of the contribution of the spectrum uncertainty to the total uncertainty in calculated spectral indices (SIs). This study identifies deficiencies in the traditional treatment of the SI uncertainty, provides simple bounds to the spectral component in the SI uncertainty estimates, verifies that these estimates are reflected in actual applications, details a methodology that rigorously captures the spectral contribution to the uncertainty in the SI, andmore » provides quantified examples that demonstrate the importance of the proper treatment the spectral contribution to the uncertainty in the SI.« less

Estimating the direct and indirect water use of tourism in the eastern Mediterranean.

PubMed

Hadjikakou, Michalis; Chenoweth, Jonathan; Miller, Graham

2013-01-15

The impact of tourism activities on local water resources remains a largely understudied issue in environmental and sustainable tourism management. The aim of the paper is to present a simple methodology that allows an estimate of direct and indirect local water use associated with different holiday packages and to then discuss relevant management implications. This is explored through the creation of five illustrative examples of holidays to semi-arid eastern Mediterranean destinations: Cyprus (2), Turkey, Greece and Syria. Using available data on water use associated with different forms of travel, accommodation and tourist activities, indicative water footprints are calculated for each of the illustrative examples. Food consumption by tourists appears to have by far the most significant impact on the overall water footprint and this aspect of water use is explored in detail in the paper. The paper also suggests a way of employing the water footprint methodology along with import/export balance sheets of main food commodities to distinguish between the global and local pressure of tourism demand on water resources. Water resource use is likely to become an increasingly important issue in tourism management and must be considered alongside more established environmental concerns such as energy use, using methodologies that can capture direct as well as supply chain impacts. Copyright © 2012 Elsevier Ltd. All rights reserved.

Hazard interactions and interaction networks (cascades) within multi-hazard methodologies

NASA Astrophysics Data System (ADS)

Gill, Joel C.; Malamud, Bruce D.

2016-08-01

This paper combines research and commentary to reinforce the importance of integrating hazard interactions and interaction networks (cascades) into multi-hazard methodologies. We present a synthesis of the differences between multi-layer single-hazard approaches and multi-hazard approaches that integrate such interactions. This synthesis suggests that ignoring interactions between important environmental and anthropogenic processes could distort management priorities, increase vulnerability to other spatially relevant hazards or underestimate disaster risk. In this paper we proceed to present an enhanced multi-hazard framework through the following steps: (i) description and definition of three groups (natural hazards, anthropogenic processes and technological hazards/disasters) as relevant components of a multi-hazard environment, (ii) outlining of three types of interaction relationship (triggering, increased probability, and catalysis/impedance), and (iii) assessment of the importance of networks of interactions (cascades) through case study examples (based on the literature, field observations and semi-structured interviews). We further propose two visualisation frameworks to represent these networks of interactions: hazard interaction matrices and hazard/process flow diagrams. Our approach reinforces the importance of integrating interactions between different aspects of the Earth system, together with human activity, into enhanced multi-hazard methodologies. Multi-hazard approaches support the holistic assessment of hazard potential and consequently disaster risk. We conclude by describing three ways by which understanding networks of interactions contributes to the theoretical and practical understanding of hazards, disaster risk reduction and Earth system management. Understanding interactions and interaction networks helps us to better (i) model the observed reality of disaster events, (ii) constrain potential changes in physical and social vulnerability between successive hazards, and (iii) prioritise resource allocation for mitigation and disaster risk reduction.

An analysis of the influence of framework aspects on the study design of health economic modeling evaluations.

PubMed

Gurtner, Sebastian

2013-04-01

Research and practical guidelines have many implications for how to structure a health economic study. A major focus in recent decades has been the quality of health economic research. In practice, the factors influencing a study design are not limited to the quest for quality. Moreover, the framework of the study is important. This research addresses three major questions related to these framework aspects. First, we want to know whether the design of health economic studies has changed over time. Second, we want to know how the subject of a study, whether it is a process or product innovation, influences the parameters of the study design. Third, one of the most important questions we will answer is whether and how the study's source of funding has an impact on the design of the research. To answer these questions, a total of 234 health economic studies were analyzed using a correspondence analysis and a logistic regression analysis. All three categories of framework factors have an influence on the aspects of the study design. Health economic studies have evolved over time, leading to the use of more advanced methods like complex sensitivity analyses. Additionally, the patient's point of view has increased in importance. The evaluation of product innovations has focused more on utility concepts. On the other hand, the source of funding may influence only a few aspects of the study design, such as the use of evaluation methods, the source of data, and the use of certain utility measures. The most important trends in health care, such as the emphasis on the patients' point of view, become increasingly established in health economic evaluations with the passage of time. Although methodological challenges remain, modern information and communication technologies provide a basis for increasing the complexity and quality of health economic studies if used frequently.

A comparative study of soviet versus western helicopters. Part 2: Evaluation of weight, maintainability and design aspects of major components

NASA Technical Reports Server (NTRS)

Stepniewski, W. Z.; Shinn, R. A.

1983-01-01

A detailed comparative insight into design and operational philosophies of Soviet vs. Western helicopters is provided. This is accomplished by examining conceptual approaches, productibility and maintainability, and weight trends/prediction methodology. Extensive use of Soviet methodology (Tishchenko) to various weight classes of helicopters is compared to the results of using Western based methodology.

Background for Joint Systems Aspects of AIR 6000

DTIC Science & Technology

2000-04-01

Checkland’s Soft Systems Methodology [7, 8,9]. The analytical techniques that are proposed for joint systems work are based on calculating probability...Supporting Global Interests 21 DSTO-CR-0155 SLMP Structural Life Management Plan SOW Stand-Off Weapon SSM Soft Systems Methodology UAV Uninhabited Aerial... Systems Methodology in Action, John Wiley & Sons, Chichester, 1990. [101 Pearl, Judea, Probabilistic Reasoning in Intelligent Systems: Networks of Plausible

Building a Better Canine Warrior

DTIC Science & Technology

2017-10-12

without adversely affecting pe r formance and to develop technical methodology that would dissipate metabolic heat without the expense o f body water...technical methodology that would dissipate metabolic heat without the expense of body water. Neither an increase in dietary salt nor decrease in...from a methodological aspect as well as emerging regulatory issues related to research in working dogs. Data suggested that the effect of high

A small perturbation based optimization approach for the frequency placement of high aspect ratio wings

NASA Astrophysics Data System (ADS)

Goltsch, Mandy

Design denotes the transformation of an identified need to its physical embodiment in a traditionally iterative approach of trial and error. Conceptual design plays a prominent role but an almost infinite number of possible solutions at the outset of design necessitates fast evaluations. The corresponding practice of empirical equations and low fidelity analyses becomes obsolete in the light of novel concepts. Ever increasing system complexity and resource scarcity mandate new approaches to adequately capture system characteristics. Contemporary concerns in atmospheric science and homeland security created an operational need for unconventional configurations. Unmanned long endurance flight at high altitudes offers a unique showcase for the exploration of new design spaces and the incidental deficit of conceptual modeling and simulation capabilities. Structural and aerodynamic performance requirements necessitate light weight materials and high aspect ratio wings resulting in distinct structural and aeroelastic response characteristics that stand in close correlation with natural vibration modes. The present research effort evolves around the development of an efficient and accurate optimization algorithm for high aspect ratio wings subject to natural frequency constraints. Foundational corner stones are beam dimensional reduction and modal perturbation redesign. Local and global analyses inherent to the former suggest corresponding levels of local and global optimization. The present approach departs from this suggestion. It introduces local level surrogate models to capacitate a methodology that consists of multi level analyses feeding into a single level optimization. The innovative heart of the new algorithm originates in small perturbation theory. A sequence of small perturbation solutions allows the optimizer to make incremental movements within the design space. It enables a directed search that is free of costly gradients. System matrices are decomposed based on a Timoshenko stiffness effect separation. The formulation of respective linear changes falls back on surrogate models that approximate cross sectional properties. Corresponding functional responses are readily available. Their direct use by the small perturbation based optimizer ensures constitutive laws and eliminates a previously necessary optimization at the local level. The scope of the present work is derived from an existing configuration such as a conceptual baseline or a prototype that experiences aeroelastic instabilities. Due to the lack of respective design studies in the traditional design process it is not uncommon for an initial wing design to have such stability problems. The developed optimization scheme allows the effective redesign of high aspect ratio wings subject to natural frequency objectives. Its successful application is demonstrated by three separate optimization studies. The implementation results of all three studies confirm that the gradient liberation of the new methodology brings about great computational savings. A generic wing study is used to indicate the connection between the proposed methodology and the aeroelastic stability problems outlined in the motivation. It is also used to illustrate an important practical aspect of structural redesign, i.e., a minimum departure from the existing baseline configuration. The proposed optimization scheme is naturally conducive to this practical aspect by using a minimum change optimization criterion. However, only an elemental formulation truly enables a minimum change solution. It accounts for the spanwise significance of a structural modification to the mode of interest. This idea of localized reinforcement greatly benefits the practical realization of structural redesign efforts. The implementation results also highlight the fundamental limitation of the proposed methodology. The exclusive consideration of mass and stiffness effects on modal response characteristics disregards other disciplinary problems such as allowable stresses or buckling loads. Both are of central importance to the structural integrity of an aircraft but are currently not accounted for in the proposed optimization scheme. The concluding discussion thus outlines the need for respective constraints and/or additional analyses to capture all requirements necessary for a comprehensive structural redesign study.

Which Brain Regions are Important for Seizure Dynamics in Epileptic Networks? Influence of Link Identification and EEG Recording Montage on Node Centralities.

PubMed

Geier, Christian; Lehnertz, Klaus

2017-02-01

Nodes in large-scale epileptic networks that are crucial for seizure facilitation and termination can be regarded as potential targets for individualized focal therapies. Graph-theoretical approaches based on centrality concepts can help to identify such important nodes, however, they may be influenced by the way networks are derived from empirical data. Here we investigate evolving functional epileptic brain networks during 82 focal seizures with different anatomical onset locations that we derive from multichannel intracranial electroencephalographic recordings from 51 patients. We demonstrate how the various methodological steps (from the recording montage via node and link inference to the assessment of node centralities) affect importance estimation and discuss their impact on the interpretability of findings in the context of pathophysiological aspects of seizure dynamics.

Uninterrupted and reusable source for the controlled growth of nanowires

PubMed Central

Sugavaneshwar, R. P.; Nanda, Karuna Kar

2013-01-01

Generally, the length of the oxide nanowires grown by vapor phase transport is limited by the degradation of the source materials. Furthermore, the source material is used once for the nanowires growth. By exploiting the Si-Zn phase diagram, we have developed a simple methodology for the non-catalytic growth of ultralong ZnO nanowires in large area with controllable aspect ratio and branched structures. The insolubility of Zn in Si and the use of a Si cap on the Zn source to prevent local source oxidation of Zn (i. e. prevents the degradation of the source) are the keys to grow longer nanowires without limitations. It has been shown that the aspect ratio can be controlled by thermodynamically (temperature) and more importantly by kinetically (vapor flux). One of the interesting findings is that the same source material can be used for several depositions of oxide nanostructured materials. PMID:23412010

Cross-cultural perspectives on critical thinking.

PubMed

Jenkins, Sheryl Daun

2011-05-01

The purpose of this cross-cultural study was to explore critical thinking among nurse scholars in Thailand and the United States. The study used qualitative methodology to examine how nurse scholars describe critical thinking in nursing. Nurse educators in Thailand and the United States were questioned concerning the following aspects of critical thinking: essential components; teaching and evaluation techniques; characteristics of critical thinkers; and the importance of a consensus definition for critical thinking in nursing. Their statements, which revealed both common and specific cultural aspects of critical thinking, were subjected to content analysis. Certain themes emerged that have not been widely discussed in the literature, including the link between staying calm and thinking critically, the assertion that happiness is an essential component of critical thinking, and the participants' nearly unanimous support for coming to a consensus definition of critical thinking for nursing. Copyright 2011, SLACK Incorporated.

A mapping of information security in health Information Systems in Latin America and Brazil.

PubMed

Pereira, Samáris Ramiro; Fernandes, João Carlos Lopes; Labrada, Luis; Bandiera-Paiva, Paulo

2013-01-01

In health, Information Systems are patient records, hospital administration or other, have advantages such as cost, availability and integration. However, for these benefits to be fully met, it is necessary to guarantee the security of information maintained and provided by the systems. The lack of security can lead to serious consequences such as lawsuits and induction to medical errors. The management of information security is complex and is used in various fields of knowledge. Often, it is left in the background for not being the ultimate goal of a computer system, causing huge financial losses to corporations. This paper by systematic review methodologies, presented a mapping in the literature, in order to identify the most relevant aspects that are addressed by security researchers of health information, as to the development of computerized systems. They conclude through the results, some important aspects, for which the managers of computerized health systems should remain alert.

The Sensory Environment and Participation of Preschool Children With Autism Spectrum Disorder.

PubMed

Piller, Aimee; Pfeiffer, Beth

2016-07-01

Sensory processing is recognized as impacting participation for preschool children with autism spectrum disorder (ASD). Little research exists to examine the impact of the sensory environment on the participation patterns of children with ASD, specifically from a contextual standpoint. The researchers in this study examined the viewpoint of teachers and occupational therapists on the sensory-related environmental barriers to participation within the preschool context. Qualitative descriptive methodology was used for data collection and analysis. Thirteen preschool teachers and occupational therapists were interviewed. Sensory aspects of the environment both inhibited and enhanced participation. Physical and temporal components of the environment are identified as being the most influential. Modifications of the environment are identified as increasing participation. It is important to consider the sensory aspects of the environment, in addition to the sensory processing patterns of the person in assessment and intervention planning within the preschool environment. © The Author(s) 2016.

Survey of systematic review authors in dentistry: challenges in methodology and reporting.

PubMed

Major, Michael P; Warren, Sharon; Flores-Mir, Carlos

2009-04-01

The study reported in this article had three objectives: 1) identify the challenges faced by authors of dental systematic reviews (SR) during the process of literature search and selection; 2) determine whether dental SR authors' responses to survey questions about their study methodology were consistent with the reported published methodology; and 3) assess whether dental SR authors' evidence-based publication experience was associated with reported methodology. Seventy-eight authors (53 percent) of dental SRs out of 147 potential authors published from 2000 to 2006 responded to an online survey. According to the respondents, the most challenging aspects of literature search and selection were the initial design and performing extended literature searches. Agreement between the protocol identified by SR authors on the survey and the actual protocol described in their publications was fair to moderate. There were virtually no correlations between authors' publication experience, systematic review literature search, and selection thoroughness except for the number of past SRs published, and no differences in thoroughness between SRs written by clinicians (dental practitioners in the community) and dental school faculty members. Dental SR authors do not appear to fully appreciate the importance of extensive literature searches as central to the validity of their systematic review methods and potential findings.

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

PubMed

Ribba, B; Grimm, H P; Agoram, B; Davies, M R; Gadkar, K; Niederer, S; van Riel, N; Timmis, J; van der Graaf, P H

2017-08-01

With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions. © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

[To understand the words of cancer: Lexonco, dictionary of oncology SOR SAVOIR PATIENT for patients and relatives. Methodological aspects].

PubMed

Delavigne, V; Carretier, J; Brusco, Sylvie; Leichtnam-Dugarin, L; Déchelette, M; Philip, Thierry

2007-04-01

In response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, the French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relatives, the SOR SAVOIR PATIENT program. Lexonco project is a dictionary on oncology adapted for patients and relatives and validated by medical experts and cancer patients. This paper describes the methodological aspects which take into account patients and experts' perspectives to produce the defi nitions.

[About History of Scientific Clinical Schools in Russia: Certain Disputable Issues of Methodology of Studying Problem].

PubMed

Borodulin, V I; Gliantsev, S P

2017-07-01

The article considers particular key methodological aspects of problem of scientific clinical school in national medicine. These aspects have to do with notion of school, its profile, issues of pedagogues, teachings and followers, subsidiary schools and issue of ethical component of scientific school. The article is a polemic one hence one will find no definite answers to specified questions. The reader is proposed to ponder over answers independently adducing examples of pro and contra. The conclusion is made about necessity of studying scientific schools in other areas of medicine and further elaboration of problem.

Urban land use: Remote sensing of ground-basin permeability

NASA Technical Reports Server (NTRS)

Tinney, L. R.; Jensen, J. R.; Estes, J. E.

1975-01-01

A remote sensing analysis of the amount and type of permeable and impermeable surfaces overlying an urban recharge basin is discussed. An effective methodology for accurately generating this data as input to a safe yield study is detailed and compared to more conventional alternative approaches. The amount of area inventoried, approximately 10 sq. miles, should provide a reliable base against which automatic pattern recognition algorithms, currently under investigation for this task, can be evaluated. If successful, such approaches can significantly reduce the time and effort involved in obtaining permeability data, an important aspect of urban hydrology dynamics.

Ergonomics for enhancing detection of machine abnormalities.

PubMed

Illankoon, Prasanna; Abeysekera, John; Singh, Sarbjeet

2016-10-17

Detecting abnormal machine conditions is of great importance in an autonomous maintenance environment. Ergonomic aspects can be invaluable when detection of machine abnormalities using human senses is examined. This research outlines the ergonomic issues involved in detecting machine abnormalities and suggests how ergonomics would improve such detections. Cognitive Task Analysis was performed in a plant in Sri Lanka where Total Productive Maintenance is being implemented to identify sensory types that would be used to detect machine abnormalities and relevant Ergonomic characteristics. As the outcome of this research, a methodology comprising of an Ergonomic Gap Analysis Matrix for machine abnormality detection is presented.

Commentary 2: Sibling Power Dynamics: The Role of Family and Sociocultural Context.

PubMed

Updegraff, Kimberly A

2017-06-01

The balance of power and control is an understudied, yet important, aspect of the sibling relationship that is theorized to shift over the course of development from early childhood to young adulthood. The investigations in this issue offer support for this overall progression, but extend prior research by providing a nuanced understanding of sibling power dynamics using different methodologies, analytic approaches, and study designs. Grounded within an ecological framework, directions for future research are offered to expand our understanding of sibling power dynamics in diverse family and sociocultural contexts. © 2017 Wiley Periodicals, Inc.

The actual citation impact of European oncological research.

PubMed

López-Illescas, Carmen; de Moya-Anegón, Félix; Moed, Henk F

2008-01-01

This study provides an overview of the research performance of major European countries in the field Oncology, the most important journals in which they published their research articles, and the most important academic institutions publishing them. The analysis was based on Thomson Scientific's Web of Science (WoS) and calculated bibliometric indicators of publication activity and actual citation impact. Studying the time period 2000-2006, it gives an update of earlier studies, but at the same time it expands their methodologies, using a broader definition of the field, calculating indicators of actual citation impact, and analysing new and policy relevant aspects. Findings suggest that the emergence of Asian countries in the field Oncology has displaced European articles more strongly than articles from the USA; that oncologists who have published their articles in important, more general journals or in journals covering other specialties, rather than in their own specialist journals, have generated a relatively high actual citation impact; and that universities from Germany, and--to a lesser extent--those from Italy, the Netherlands, UK, and Sweden, dominate a ranking of European universities based on number of articles in oncology. The outcomes illustrate that different bibliometric methodologies may lead to different outcomes, and that outcomes should be interpreted with care.

Is the intensive care unit traumatic? What we know and don't know about the intensive care unit and posttraumatic stress responses.

PubMed

McGiffin, Jed N; Galatzer-Levy, Isaac R; Bonanno, George A

2016-05-01

The intensive care unit (ICU) has been portrayed as psychologically stressful, with a growing body of research substantiating elevated rates of depression, posttraumatic stress disorder (PTSD), and other psychological disruptions in populations of critical care survivors. To explain these psychopathology elevations, some have proposed a direct effect of ICU admission upon the later development of psychopathology, whereas others highlight the complex interaction between the trauma of a life-threatening illness or injury and the stressful life-saving interventions often administered in the ICU. However, the conclusion that the ICU is an independent causal factor in trauma-related psychological outcomes may be premature. Current ICU research suffers from important methodological problems including lack of true prospective data, failure to employ appropriate comparison groups, sampling bias, measurement issues, and problems with statistical methodology. In addition, the ICU literature has yet to investigate important risk and resilience factors that have been empirically validated in the broader stress-response literature. The authors propose the application of these important constructs to the unique setting of the ICU. This review focuses on multiple aspects of the important but complex research question of whether the ICU confers risk for psychological distress above and beyond the traumatic impact of the serious health events that necessitate ICU treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Final report to the Florida Department of Transportation Systems Planning Office on project "Improvements and enhancements to LOSPLAN 2007".

DOT National Transportation Integrated Search

2011-03-01

This project addressed several aspects of the LOSPLAN software, primarily with respect to incorporating : new FDOT and NCHRP research project results. In addition, some existing computational methodology : aspects were refined to provide more accurat...

Noise and Man 󈨡. Noise as a Public Health Problem. Proceedings of the International Congress (6th) Held in Nice on July 5 - 9, 1993

DTIC Science & Technology

1993-07-01

the need to consider complex interactions such that certain exposure or modulating factors may contribute differentially to the different aspects of...14 Vogel A International aspects of noise...Night time noise sources and sleep disturbance, methodological issues and critical load - Sources de bruit et troubles du sommeil, aspects

Operationalising the health aspects of sustainable diets: a review.

PubMed

Mertens, Elly; Van't Veer, Pieter; Hiddink, Gerrit J; Steijns, Jan Mjm; Kuijsten, Anneleen

2017-03-01

Shifting towards a more sustainable food consumption pattern is an important strategy to mitigate climate change. In the past decade, various studies have optimised environmentally sustainable diets using different methodological approaches. The aim of the present review was to categorise and summarise the different approaches to operationalise the health aspects of environmentally sustainable diets. Conventional keyword and reference searches were conducted in PubMed, Scopus, Web of Knowledge and CAB Abstracts. Inclusion criteria were: (i) English-language publication; (ii) published between 2005 and October 2015; (iii) dietary data collected for the diet as a whole at the national, household or individual level; (iv) comparison of the current diet with dietary scenarios; and (v) for results to consider the health aspect in some way. Consumer diets. Adult population. We reviewed forty-nine studies that combined the health and environmental aspects of consumer diets. Hereby, five approaches to operationalise the health aspect of the diet were identified: (i) food item replacements; (ii) dietary guidelines; (iii) dietary quality scores; (iv) diet modelling techniques; and (v) diet-related health impact analysis. Although the sustainability concept is increasingly popular and widely advocated by nutritional and environmental scientists, the journey towards designing sustainable diets for consumers has only just begun. In the context of operationalising the health aspects, diet modelling might be considered the preferred approach since it captures the complexity of the diet as a whole. For the future, we propose SHARP diets: environmentally Sustainable (S), Healthy (H), Affordable (A), Reliable (R) and Preferred from the consumer's perspective (P).

A New Methodology for Systematic Exploitation of Technology Databases.

ERIC Educational Resources Information Center

Bedecarrax, Chantal; Huot, Charles

1994-01-01

Presents the theoretical aspects of a data analysis methodology that can help transform sequential raw data from a database into useful information, using the statistical analysis of patents as an example. Topics discussed include relational analysis and a technology watch approach. (Contains 17 references.) (LRW)

Advocating for Additional Aspects of Quality

ERIC Educational Resources Information Center

Herbel-Eisenmann, Beth A.

2016-01-01

Across the set of articles in this Special Issue, various authors describe methodology and methodological decisions, illustrate analyses, and share emerging findings from The Evolution of the Discourse of School Mathematics (EDSM) project. In general, the investigators were interested in identifying "changes over time in the kind of…

Spanish methodological approach for biosphere assessment of radioactive waste disposal.

PubMed

Agüero, A; Pinedo, P; Cancio, D; Simón, I; Moraleda, M; Pérez-Sánchez, D; Trueba, C

2007-10-01

The development of radioactive waste disposal facilities requires implementation of measures that will afford protection of human health and the environment over a specific temporal frame that depends on the characteristics of the wastes. The repository design is based on a multi-barrier system: (i) the near-field or engineered barrier, (ii) far-field or geological barrier and (iii) the biosphere system. Here, the focus is on the analysis of this last system, the biosphere. A description is provided of conceptual developments, methodological aspects and software tools used to develop the Biosphere Assessment Methodology in the context of high-level waste (HLW) disposal facilities in Spain. This methodology is based on the BIOMASS "Reference Biospheres Methodology" and provides a logical and systematic approach with supplementary documentation that helps to support the decisions necessary for model development. It follows a five-stage approach, such that a coherent biosphere system description and the corresponding conceptual, mathematical and numerical models can be built. A discussion on the improvements implemented through application of the methodology to case studies in international and national projects is included. Some facets of this methodological approach still require further consideration, principally an enhanced integration of climatology, geography and ecology into models considering evolution of the environment, some aspects of the interface between the geosphere and biosphere, and an accurate quantification of environmental change processes and rates.

Design of a general methodology for the evaluation and categorization of an environmental program with special reference to Costa Rica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castillo, H.

1982-01-01

The Government of Costa Rica has stated the need for a formal procedure for the evaluation and categorization of an environmental program. Methodological studies were prepared as the basis for the development of the general methodology by which each government or institution can adapt and implement the procedure. The methodology was established by using different techniques according to their contribution to the evaluation process, such as: Systemic Approach, Delphi, and Saaty Methods. The methodology consists of two main parts: 1) evaluation of the environmental aspects by using different techniques; 2) categorization of the environmental aspects by applying the methodology tomore » the Costa Rican Environmental affairs using questionnaire answers supplied by experts both inside and outside of the country. The second part of the research includes Appendixes in which is presented general information concerning institutions related to environmental affairs; description of the methods used; results of the current status evaluation and its scale; the final scale of categorization; and the questionnaires and a list of experts. The methodology developed in this research will have a beneficial impact on environmental concerns in Costa Rica. As a result of this research, a Commission Office of Environmental Affairs, providing links between consumers, engineers, scientists, and the Government, is recommended. Also there is significant potential use of this methodology in developed countries for a better balancing of the budgets of major research programs such as cancer, heart, and other research areas.« less

Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review

PubMed Central

Möller, Winfried; Pagels, Joakim H.; Kreyling, Wolfgang G.; Swietlicki, Erik; Schmid, Otmar

2014-01-01

Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract deposition of nano-sized particles, analyze critical experimental design aspects causing measurement uncertainties, and suggest methodologies for future studies. It is shown that, although particle detection techniques have developed with time, the overall methodology in respiratory tract deposition experiments has not seen similar progress. Available experience from previous research has often not been incorporated, and some methodological design aspects that were overlooked in 30–70% of all studies may have biased the experimental data. This has contributed to a significant uncertainty on the absolute value of the lung deposition fraction of nanoparticles. We estimate the impact of the design aspects on obtained data, discuss solutions to minimize errors, and highlight gaps in the available experimental set of data. PMID:24151837

Quasi-experimental study designs series-paper 10: synthesizing evidence for effects collected from quasi-experimental studies presents surmountable challenges.

PubMed

Becker, Betsy Jane; Aloe, Ariel M; Duvendack, Maren; Stanley, T D; Valentine, Jeffrey C; Fretheim, Atle; Tugwell, Peter

2017-09-01

To outline issues of importance to analytic approaches to the synthesis of quasi-experiments (QEs) and to provide a statistical model for use in analysis. We drew on studies of statistics, epidemiology, and social-science methodology to outline methods for synthesis of QE studies. The design and conduct of QEs, effect sizes from QEs, and moderator variables for the analysis of those effect sizes were discussed. Biases, confounding, design complexities, and comparisons across designs offer serious challenges to syntheses of QEs. Key components of meta-analyses of QEs were identified, including the aspects of QE study design to be coded and analyzed. Of utmost importance are the design and statistical controls implemented in the QEs. Such controls and any potential sources of bias and confounding must be modeled in analyses, along with aspects of the interventions and populations studied. Because of such controls, effect sizes from QEs are more complex than those from randomized experiments. A statistical meta-regression model that incorporates important features of the QEs under review was presented. Meta-analyses of QEs provide particular challenges, but thorough coding of intervention characteristics and study methods, along with careful analysis, should allow for sound inferences. Copyright © 2017 Elsevier Inc. All rights reserved.

A Methodology for Training International Space Station Crews to Respond to On-Orbit Emergencies

NASA Technical Reports Server (NTRS)

Balmain, Clinton; Fleming, Mark

2009-01-01

Most spaceflight crewmembers agree that emergency training is among the most important training they receive. If an emergency event occurs on-orbit crewmembers want to be able to rely on a thorough and proficient knowledge of emergency operations and procedures. The inherent complexity of ISS and the international nature of the onboard operations have resulted in emergency procedures that are complex by any measure; as a result, a very robust apparatus has been developed to give crewmembers initial training on emergency procedures and ensure proficiency up to (and even after) launch. One of the most important aspects of complex onboard operations in general, and emergency operations specifically, is learning how to coordinate roles and responsibilities with fellow crewmembers. A primary goal of NASA s emergency training program is to allow the crewmembers who will actually be together on-orbit to practice executing the emergency responses together before they fly. As with any operation that includes the use of software and hardware, the fidelity of the simulation environment is a critical element to successful training. The NASA training division has spent considerable time and effort to develop a simulator that addresses the most important aspects of emergency response, working within very difficult space and budgetary constraints.

Uncertainty, the Overbearing Lived Experience of the Elderly People Undergoing Hemodialysis: A Qualitative Study

PubMed Central

Sahaf, Robab; Sadat Ilali, Ehteram; Peyrovi, Hamid; Akbari Kamrani, Ahmad Ali; Spahbodi, Fatemeh

2017-01-01

ABSTRACT Background: The chronic kidney disease is a major health concern. The number of the elderly people with chronic renal failure has increased across the world. Dialysis is an appropriate therapy for the elderly, but it involves certain challenges. The present paper reports uncertainty as part of the elderly experiences of living with hemodialysis. Methods: This qualitative study applied Max van Manen interpretative phenomenological analysis to explain and explore experiences of the elderly with hemodialysis. Given the study inclusion criteria, data were collected using in-depth unstructured interviews with nine elderly undergoing hemodialysis, and then analyzed according to Van Manen 6-stage methodological approach. Results: One of the most important findings emerging in the main study was “uncertainty”, which can be important and noteworthy, given other aspects of the elderly life (loneliness, despair, comorbidity of diseases, disability, and mental and psychosocial problems). Uncertainty about the future is the most psychological concerns of people undergoing hemodialysis. Conclusion: The results obtained are indicative of the importance of paying attention to a major aspect in the life of the elderly undergoing hemodialysis, uncertainty. A positive outlook can be created in the elderly through education and increased knowledge about the disease, treatment and complications. PMID:28097174

Randomized Controlled Trials in Music Therapy: Guidelines for Design and Implementation.

PubMed

Bradt, Joke

2012-01-01

Evidence from randomized controlled trials (RCTs) plays a powerful role in today's healthcare industry. At the same time, it is important that multiple types of evidence contribute to music therapy's knowledge base and that the dialogue of clinical effectiveness in music therapy is not dominated by the biomedical hierarchical model of evidence-based practice. Whether or not one agrees with the hierarchical model of evidence in the current healthcare climate, RCTs can contribute important knowledge to our field. Therefore, it is important that music therapists are prepared to design trials that meet current methodological standards and, equally important, are able to respond appropriately to those design aspects that may not be feasible in music therapy research. To provide practical guidelines to music therapy researchers for the design and implementation of RCTs as well as to enable music therapists to be well-informed consumers of RCT evidence. This article reviews key design aspects of RCTs and discusses how to best implement these standards in music therapy trials. A systematic presentation of basic randomization methods, allocation concealment strategies, issues related to blinding in music therapy trials and strategies for implementation, the use of treatment manuals, types of control groups, outcome selection, and sample size computation is provided. Despite the challenges of meeting all key design demands typical of an RCT, it is possible to design rigorous music therapy RCTs that accurately estimate music therapy treatment benefits.

77 FR 4002 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-26

... the methodological research previously included in the original System of Record Notice (SORN). This... methodological research on improving various aspects of surveys authorized by Title 13, U.S.C. 8(b), 182, and 196, such as: survey sampling frame design; sample selection algorithms; questionnaire development, design...

Neurolinguistic Foundations to Methods of Teaching a Second Language

ERIC Educational Resources Information Center

Walsh, Terrence; Diller, Karl

1978-01-01

A study of the functional aspects of Wernicke's and Broca's areas of the cerebral cortex and their relationship to second language learning and ability. Some implications are drawn regarding second language teaching and methodology. There seems to be a relationship between methodology and the neurological mechanism used by students. (AMH)

Ontological, Epistemological and Methodological Assumptions: Qualitative versus Quantitative

ERIC Educational Resources Information Center

Ahmed, Abdelhamid

2008-01-01

The review to follow is a comparative analysis of two studies conducted in the field of TESOL in Education published in "TESOL QUARTERLY." The aspects to be compared are as follows. First, a brief description of each study will be presented. Second, the ontological, epistemological and methodological assumptions underlying each study…

Ethical Dilemmas in Qualitative Research Methodology: Researcher's Reflections

ERIC Educational Resources Information Center

Ngozwana, Nomazulu

2018-01-01

This article examines the ethical dilemmas that are specific to qualitative research methodology. These dilemmas concern the issues of withdrawal from the study, anonymity and confidentiality, which are discussed. Each aspect examines how it was dealt with using the researcher's reflections. The research was positioned within an interpretive…

Constraint-Driven Software Design: An Escape from the Waterfall Model.

ERIC Educational Resources Information Center

de Hoog, Robert; And Others

1994-01-01

Presents the principles of a development methodology for software design based on a nonlinear, product-driven approach that integrates quality aspects. Two examples are given to show that the flexibility needed for building high quality systems leads to integrated development environments in which methodology, product, and tools are closely…

History Teaching in Albania Following Educational Reform in 2008

ERIC Educational Resources Information Center

Vuka, Denis

2015-01-01

This article explores history teaching in Albania, with particular emphasis on educational and methodological aspects of new history textbooks published after the liberalization of the school textbook market in 2008. National history textbooks serve as a basis for the assessment of changing educational principles and methodologies in history…

OPTIMIZATION METHODOLOGY FOR LAND USE PATTERNS-EVALUATION BASED ON MULTISCALE HABITAT PATTERN COMPARISON. (R827169)

EPA Science Inventory

In this paper, the methodological concept of landscape optimization presented by Seppelt and Voinov [Ecol. Model. 151 (2/3) (2002) 125] is analyzed. Two aspects are chosen for detailed study. First, we generalize the performance criterion to assess a vector of ecosystem functi...

Does convenience matter in health care delivery? A systematic review of convenience-based aspects of process utility.

PubMed

Higgins, A; Barnett, J; Meads, C; Singh, J; Longworth, L

2014-12-01

To systematically review the existing literature on the value associated with convenience in health care delivery, independent of health outcomes, and to try to estimate the likely magnitude of any value found. A systematic search was conducted for previously published studies that reported preferences for convenience-related aspects of health care delivery in a manner that was consistent with either cost-utility analysis or cost-benefit analysis. Data were analyzed in terms of the methodologies used, the aspects of convenience considered, and the values reported. Literature searches generated 4715 records. Following a review of abstracts or full-text articles, 27 were selected for inclusion. Twenty-six studies reported some evidence of convenience-related process utility, in the form of either a positive utility or a positive willingness to pay. The aspects of convenience valued most often were mode of administration (n = 11) and location of treatment (n = 6). The most common valuation methodology was a discrete-choice experiment containing a cost component (n = 15). A preference for convenience-related process utility exists, independent of health outcomes. Given the diverse methodologies used to calculate it, and the range of aspects being valued, however, it is difficult to assess how large such a preference might be, or how it may be effectively incorporated into an economic evaluation. Increased consistency in reporting these preferences is required to assess these issues more accurately. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Polyandry-fecundity relationship in insects: methodological and conceptual problems.

PubMed

Torres-Vila, L M

2013-02-01

Polyandry is perhaps the most puzzling component of mating systems because the fitness benefits for females of mating with more than one male during lifetime are poorly understood. The occurrence and extent of polyandry varies considerably both among and within species, and a positive association between polyandry and fecundity is widespread but not universal. The scenario is further complicated because the scientific literature on this issue includes studies that are often inconclusive or contradictory even for the same target species. A previous meta-analysis detected the crucial importance of two usually neglected aspects that potentially bias the interpretation of primary studies about the polyandry-fecundity relationship: the methodological approach--experimental or descriptive--and the polyandry concept itself--realized or potential. In this paper, we experimentally test the effect of these aspects with the moth Lobesia botrana. We used an innovative protocol in which the experimental and the descriptive methods were conducted simultaneously on the same target population and the results were then interpreted from the perspective of both concepts of polyandry. The results clearly showed that 1) the conclusions about the polyandry-fecundity relationship were strongly dependent on the methodological approach used and 2) the concept of polyandry invoked by the researcher was a confounding effect that potentially biases data interpretation. We suggest that greater attention must be paid to intraspecific variation among females in their propensity to remate. The differentiation in experimental studies between potentially polyandrous and monandrous phenotypes could greatly improve our knowledge about the maintenance of female mating polymorphism in most species and the adaptive significance of polyandry. © 2012 The Author. Journal of Evolutionary Biology © 2012 European Society For Evolutionary Biology.

Using social media to communicate during crises: an analytic methodology

NASA Astrophysics Data System (ADS)

Greene, Marjorie

2011-06-01

The Emerging Media Integration Team at the Department of the Navy Office of Information (CHINFO) has recently put together a Navy Command Social Media Handbook designed to provide information needed to safely and effectively use social media. While not intended to be a comprehensive guide on command use of social media or to take the place of official policy, the Handbook provides a useful guide for navigating a dynamic communications environment. Social media are changing the way information is diffused and decisions are made, especially for Humanitarian Assistance missions when there is increased emphasis on Navy commands to share critical information with other Navy command sites, government, and official NGO (nongovernmental organization) sites like the American Red Cross. In order to effectively use social media to support such missions, the Handbook suggests creating a centralized location to funnel information. This suggests that as the community of interest (COI) grows during a crisis, it will be important to ensure that information is shared with appropriate organizations for different aspects of the mission such as evacuation procedures, hospital sites, location of seaports and airports, and other topics relevant to the mission. For example, in the first 14 days of the U.S. Southern Command's Haiti HA/DR (Humanitarian Assistance/Disaster Relief) mission, the COI grew to over 1,900 users. In addition, operational conditions vary considerably among incidents, and coordination between different groups is often set up in an ad hoc manner. What is needed is a methodology that will help to find appropriate people with whom to share information for particular aspects of a mission during a wide range of events related to the mission. CNA has developed such a methodology and we would like to test it in a small scale lab experiment.

Recent developments in assessment of long-term radionuclide behavior in the geosphere-biosphere subsystem.

PubMed

Smith, G M; Smith, K L; Kowe, R; Pérez-Sánchez, D; Thorne, M; Thiry, Y; Read, D; Molinero, J

2014-05-01

Decisions on permitting, controlling and monitoring releases of radioactivity into the environment rely on a great variety of factors. Important among these is the prospective assessment of radionuclide behavior in the environment, including migration and accumulation among and within specific environmental media, and the resulting environmental and human health impacts. Models and techniques to undertake such assessments have been developed over several decades based on knowledge of the ecosystems involved, as well as monitoring of previous radionuclide releases to the environment, laboratory experiments and other related research. This paper presents developments in the assessment of radiation doses and related research for some of the key radionuclides identified as of potential significance in the context of releases to the biosphere from disposal facilities for solid radioactive waste. Since releases to the biosphere from disposal facilities involve transfers from the geosphere to the biosphere, an important aspect is the combined effects of surface hydrology, near-surface hydrogeology and chemical gradients on speciation and radionuclide mobility in the zone in which the geosphere and biosphere overlap (herein described as the geosphere-biosphere subsystem). In turn, these aspects of the environment can be modified as a result of environmental change over the thousands of years that have to be considered in radioactive waste disposal safety assessments. Building on the experience from improved understanding of the behavior of the key radionuclides, this paper proceeds to describe development of a generic methodology for representing the processes and environmental changes that are characteristic of the interface between the geosphere and the biosphere. The information that is provided and the methodology that is described are based on international collaborative work implemented through the BIOPROTA forum, www.bioprota.org. Copyright © 2013 Elsevier Ltd. All rights reserved.

Cluster-randomized Studies in Educational Research: Principles and Methodological Aspects

PubMed Central

Dreyhaupt, Jens; Mayer, Benjamin; Keis, Oliver; Öchsner, Wolfgang; Muche, Rainer

2017-01-01

An increasing number of studies are being performed in educational research to evaluate new teaching methods and approaches. These studies could be performed more efficiently and deliver more convincing results if they more strictly applied and complied with recognized standards of scientific studies. Such an approach could substantially increase the quality in particular of prospective, two-arm (intervention) studies that aim to compare two different teaching methods. A key standard in such studies is randomization, which can minimize systematic bias in study findings; such bias may result if the two study arms are not structurally equivalent. If possible, educational research studies should also achieve this standard, although this is not yet generally the case. Some difficulties and concerns exist, particularly regarding organizational and methodological aspects. An important point to consider in educational research studies is that usually individuals cannot be randomized, because of the teaching situation, and instead whole groups have to be randomized (so-called “cluster randomization”). Compared with studies with individual randomization, studies with cluster randomization normally require (significantly) larger sample sizes and more complex methods for calculating sample size. Furthermore, cluster-randomized studies require more complex methods for statistical analysis. The consequence of the above is that a competent expert with respective special knowledge needs to be involved in all phases of cluster-randomized studies. Studies to evaluate new teaching methods need to make greater use of randomization in order to achieve scientifically convincing results. Therefore, in this article we describe the general principles of cluster randomization and how to implement these principles, and we also outline practical aspects of using cluster randomization in prospective, two-arm comparative educational research studies. PMID:28584874

Cluster-randomized Studies in Educational Research: Principles and Methodological Aspects.

PubMed

Dreyhaupt, Jens; Mayer, Benjamin; Keis, Oliver; Öchsner, Wolfgang; Muche, Rainer

2017-01-01

An increasing number of studies are being performed in educational research to evaluate new teaching methods and approaches. These studies could be performed more efficiently and deliver more convincing results if they more strictly applied and complied with recognized standards of scientific studies. Such an approach could substantially increase the quality in particular of prospective, two-arm (intervention) studies that aim to compare two different teaching methods. A key standard in such studies is randomization, which can minimize systematic bias in study findings; such bias may result if the two study arms are not structurally equivalent. If possible, educational research studies should also achieve this standard, although this is not yet generally the case. Some difficulties and concerns exist, particularly regarding organizational and methodological aspects. An important point to consider in educational research studies is that usually individuals cannot be randomized, because of the teaching situation, and instead whole groups have to be randomized (so-called "cluster randomization"). Compared with studies with individual randomization, studies with cluster randomization normally require (significantly) larger sample sizes and more complex methods for calculating sample size. Furthermore, cluster-randomized studies require more complex methods for statistical analysis. The consequence of the above is that a competent expert with respective special knowledge needs to be involved in all phases of cluster-randomized studies. Studies to evaluate new teaching methods need to make greater use of randomization in order to achieve scientifically convincing results. Therefore, in this article we describe the general principles of cluster randomization and how to implement these principles, and we also outline practical aspects of using cluster randomization in prospective, two-arm comparative educational research studies.

Research and Clinical Center for Child Development Annual Report, 1984-1985.

ERIC Educational Resources Information Center

Miyake, Kazuo, Ed.

The seven articles in this annual report concern aspects of attachment, social interaction among parents and children, temperament, affective behavior, and/or research methodology. Aspects of attachment and temperament are addressed in Kazuo Miyake's study of the "Relation of Temperamental Disposition to Classification of Attachment,"…

Integrating Sustainable Development into Operations Management Courses

ERIC Educational Resources Information Center

Fredriksson, Peter; Persson, Magnus

2011-01-01

Purpose: It is widely acknowledged that aspects of sustainable development (SD) should be integrated into higher level operations management (OM) education. The aim of the paper is to outline the experiences gained at Chalmers University of Technology in Sweden from integrating aspects of SD into OM courses. Design/methodology/approach: The paper…

Positive Aspects of International Student Transitions: A Qualitative Inquiry

ERIC Educational Resources Information Center

Moores, Lisa; Popadiuk, Natalee

2011-01-01

Despite the considerable growth of the international student population, positive aspects of their experience have received little attention. The current study combines a Critical Incident Technique methodology and a positive psychology lens to explore the cross-cultural transition of seven international students, focusing on facilitative factors,…

Constituent Aspects of Workplace Guidance in Secondary VET

ERIC Educational Resources Information Center

Swager, Robert; Klarus, Ruud; van Merriënboer, Jeroen J. G.; Nieuwenhuis, Loek F. M.

2015-01-01

Purpose: This paper aims to present an integrated model of workplace guidance to enhance awareness of what constitutes good guidance, to improve workplace guidance practices in vocational education and training. Design/methodology/approach: To identify constituent aspects of workplace guidance, a systematic search of Web of Science was conducted,…

Collective Academic Supervision: A Model for Participation and Learning in Higher Education

ERIC Educational Resources Information Center

Nordentoft, Helle Merete; Thomsen, Rie; Wichmann-Hansen, Gitte

2013-01-01

Supervision of graduate students is a core activity in higher education. Previous research on graduate supervision focuses on individual and relational aspects of the supervisory relationship rather than collective, pedagogical and methodological aspects of the supervision process. In presenting a collective model we have developed for academic…

Animal models for studying homeopathy and high dilutions: conceptual critical review.

PubMed

Bonamin, Leoni Villano; Endler, Peter Christian

2010-01-01

This is a systematic review of the animal models used in studies of high dilutions. The objectives are to analyze methodological quality of papers and reported results, and to highlight key conceptual aspects of high dilution to suggest clues concerning putative mechanisms of action. Papers for inclusion were identified systematically, from the Pubmed-Medline database, using 'Homeopathy' and 'Animal' as keywords. Only original full papers in English published between January 1999 and June 2009 were included, reviews, scientific reports, thesis, older papers, papers extracted from Medline using similar keywords, papers about mixed commercial formulas and books were also considered for discussion only. 31 papers describing 33 experiments were identified for the main analysis and a total of 89 items cited. Systematic analysis of the selected papers yielded evidence of some important intrinsic features of high dilution studies performed in animal models: a) methodological quality was generally adequate, some aspects could be improved; b) convergence between results and materia medica is seen in some studies, pointing toward to the possibility of systematic study of the Similia principle c) both isopathic and Similia models seem useful to understand some complex biological phenomena, such as parasite-host interactions; d) the effects of high dilutions seem to stimulate restoration of a 'stable state', as seen in several experimental models from both descriptive and mathematical points of view. Copyright 2009 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

Use of LiDAR for calculating solar irradiance on roofs and façades of buildings at city scale: Methodology, validation, and analysis

NASA Astrophysics Data System (ADS)

Cheng, Liang; Xu, Hao; Li, Shuyi; Chen, Yanming; Zhang, Fangli; Li, Manchun

2018-04-01

As the rate of urbanization continues to accelerate, the utilization of solar energy in buildings plays an increasingly important role in sustainable urban development. For this purpose, we propose a LiDAR-based joint approach for calculating the solar irradiance incident on roofs and façades of buildings at city scale, which includes a methodology for calculating solar irradiance, the validation of the proposed method, and analysis of its application. The calculation of surface irradiance on buildings may then inform photovoltaic power generation simulations, architectural design, and urban energy planning. Application analyses of the proposed method in the experiment area found that: (1) Global and direct irradiations vary significantly by hour, day, month and season, both following the same trends; however, diffuse irradiance essentially remains unchanged over time. (2) Roof irradiation, but not façade irradiation, displays distinct time-dependent patterns. (3) Global and direct irradiations on roofs are highly correlated with roof aspect and slope, with high global and direct irradiations observed on roofs of aspect 100-250° and slopes of 0-60°, whereas diffuse irradiation on roofs is only affected by roof slope. (4) The façade of a building receives higher levels of global and direct irradiations if facing southeast, south, and southwest; however, diffuse irradiation remains constant regardless of façade orientation.

a Risk Based Methodology to Assess the Energy Efficiency Improvements in Traditionally Constructed Buildings

NASA Astrophysics Data System (ADS)

Herrera, D.; Bennadji, A.

2013-07-01

In order to achieve the CO2 reduction targets set by the Scottish government, it will be necessary to improve the energy efficiency of existing buildings. Within the total Scottish building stock, historic and traditionally constructed buildings are an important proportion, in the order of 19 % (Curtis, 2010), and represent cultural, emotional and identity values that should be protected. However, retrofit interventions could be a complex operation because of the several aspects that are involved in the hygrothermal performance of traditional buildings. Moreover, all these factors interact with each other and therefore need to be analysed as a whole. Upgrading the envelope of traditional buildings may produce severe changes to the moisture migration leading to superficial or interstitial condensation and thus fabric decay and mould growth. Retrofit projects carried out in the past have failed because of the misunderstanding, or the lack of expert prediction, of the potential consequences associated to the envelope's alteration. The evaluation of potential risks, prior to any alteration on building's physics in order to improve its energy efficiency, is critical to avoid future damage on the wall's performance or occupants' health and well being. The aim of this PhD research project is to point out the most critical aspects related to the energy efficiency improvement of traditional buildings and to develop a risk based methodology that helps owners and practitioners during the decision making process.

Moderators of the Association Between Peer and Target Adolescent Substance Use

PubMed Central

Marschall-Lévesque, Shawn; Castellanos-Ryan, Natalie; Vitaro, Frank; Séguin, Jean R.

2013-01-01

Associating with substance using peers is generally considered as one of the most important predictors of adolescent substance use. However, peer association does not affect all adolescents in the same way. To better understand when and under what conditions peer association is most linked with adolescent substance use (SU), this review focuses on the factors that may operate as moderators of this association. The review highlighted several potential moderators reflecting adolescents’ individual characteristics (e.g., pubertal status, genes and personality), peer and parental factors (e.g., nature of relationships and parental monitoring), and contextual factors (e.g., peer, school and neighborhood context). As peer association is a broad concept, important methodological aspects were also addressed in order to illustrate how they can potentially bias interpretation. Taking these into account, we suggest that, while the effects of some moderators are clear (e.g., parental monitoring and sensation seeking), others are less straightforward (e.g., neighborhood) and need to be further examined. This review also provides recommendations for addressing different methodological concerns in the study of moderators, including: the use of longitudinal and experimental studies and the use of mediated moderation. These will be key for developing theory and effective prevention. PMID:24183303

Iterated transportation simulations for Dallas and Portland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagel, K.; Simon, P.; Rickert, M.

1998-09-02

The goal of the TRansportation ANalysis and SIMulation System (TRANSIMS) is to combine the most important aspects of human decision-making related to transportation, from activities planning (sleep, work, eat, shop,...) via modal and route planning to driving, into a single, consistent methodological and software framework. This is meant to combine the functionalities of activities-based travel demand generation, modal choice and route assignment, and micro-simulation. TRANSIMS attempts to employ advanced methodologies in all these modules. Yet, it is probably the overall framework that is the most important part of this attempt. It is, for example, possible to replace the TRANSIMS microsimulationmore » by another micro-simulation that uses the same input and generates the same output. TRANSIMS uses specific regions as examples in order to ensure that the technology is rooted in the real world. Until about the middle of 1997, an approximately five miles by five miles area in Dallas/Texas was used. Since then, TRANSIMS has moved to using data from Portland/Oregon; a case study for this region is planned to be completed by the end of the year 2000. In this paper the authors give short descriptions of these projects and give references to related publications.« less

Coastal risk forecast system

NASA Astrophysics Data System (ADS)

Sabino, André; Poseiro, Pedro; Rodrigues, Armanda; Reis, Maria Teresa; Fortes, Conceição J.; Reis, Rui; Araújo, João

2018-03-01

The run-up and overtopping by sea waves are two of the main processes that threaten coastal structures, leading to flooding, destruction of both property and the environment, and harm to people. To build early warning systems, the consequences and associated risks in the affected areas must be evaluated. It is also important to understand how these two types of spatial information integrate with sensor data sources and the risk assessment methodology. This paper describes the relationship between consequences and risk maps, their role in risk management and how the HIDRALERTA system integrates both aspects in its risk methodology. It describes a case study for Praia da Vitória Port, Terceira Island, Azores, Portugal, showing that the main innovations in this system are twofold: it represents the overtopping flow and consequent flooding, which are critical for coastal and port areas protected by maritime structures, and it works also as a risk assessment tool, extremely important for long-term planning and decision-making. Moreover, the implementation of the system considers possible known variability issues, enabling changes in its behaviour as needs arise. This system has the potential to become a useful tool for the management of coastal and port areas, due to its capacity to effectively issue warnings and assess risks.

Coastal risk forecast system

NASA Astrophysics Data System (ADS)

Sabino, André; Poseiro, Pedro; Rodrigues, Armanda; Reis, Maria Teresa; Fortes, Conceição J.; Reis, Rui; Araújo, João

2018-04-01

The run-up and overtopping by sea waves are two of the main processes that threaten coastal structures, leading to flooding, destruction of both property and the environment, and harm to people. To build early warning systems, the consequences and associated risks in the affected areas must be evaluated. It is also important to understand how these two types of spatial information integrate with sensor data sources and the risk assessment methodology. This paper describes the relationship between consequences and risk maps, their role in risk management and how the HIDRALERTA system integrates both aspects in its risk methodology. It describes a case study for Praia da Vitória Port, Terceira Island, Azores, Portugal, showing that the main innovations in this system are twofold: it represents the overtopping flow and consequent flooding, which are critical for coastal and port areas protected by maritime structures, and it works also as a risk assessment tool, extremely important for long-term planning and decision-making. Moreover, the implementation of the system considers possible known variability issues, enabling changes in its behaviour as needs arise. This system has the potential to become a useful tool for the management of coastal and port areas, due to its capacity to effectively issue warnings and assess risks.

Development of Methodologies for the Estimation of Thermal Properties Associated with Aerospace Vehicles

NASA Technical Reports Server (NTRS)

Scott, Elaine P.

1996-01-01

A thermal stress analysis is an important aspect in the design of aerospace structures and vehicles such as the High Speed Civil Transport (HSCT) at the National Aeronautics and Space Administration Langley Research Center (NASA-LaRC). These structures are complex and are often composed of numerous components fabricated from a variety of different materials. The thermal loads on these structures induce temperature variations within the structure, which in turn result in the development of thermal stresses. Therefore, a thermal stress analysis requires knowledge of the temperature distributions within the structures which consequently necessitates the need for accurate knowledge of the thermal properties, boundary conditions and thermal interface conditions associated with the structural materials. The goal of this proposed multi-year research effort was to develop estimation methodologies for the determination of the thermal properties and interface conditions associated with aerospace vehicles. Specific objectives focused on the development and implementation of optimal experimental design strategies and methodologies for the estimation of thermal properties associated with simple composite and honeycomb structures. The strategy used in this multi-year research effort was to first develop methodologies for relatively simple systems and then systematically modify these methodologies to analyze complex structures. This can be thought of as a building block approach. This strategy was intended to promote maximum usability of the resulting estimation procedure by NASA-LARC researchers through the design of in-house experimentation procedures and through the use of an existing general purpose finite element software.

A hierarchical-multiobjective framework for risk management

NASA Technical Reports Server (NTRS)

Haimes, Yacov Y.; Li, Duan

1991-01-01

A broad hierarchical-multiobjective framework is established and utilized to methodologically address the management of risk. United into the framework are the hierarchical character of decision-making, the multiple decision-makers at separate levels within the hierarchy, the multiobjective character of large-scale systems, the quantitative/empirical aspects, and the qualitative/normative/judgmental aspects. The methodological components essentially consist of hierarchical-multiobjective coordination, risk of extreme events, and impact analysis. Examples of applications of the framework are presented. It is concluded that complex and interrelated forces require an analysis of trade-offs between engineering analysis and societal preferences, as in the hierarchical-multiobjective framework, to successfully address inherent risk.

Towards the methodological optimization of the moss bag technique in terms of contaminants concentrations and replicability values

NASA Astrophysics Data System (ADS)

Ares, A.; Fernández, J. A.; Carballeira, A.; Aboal, J. R.

2014-09-01

The moss bag technique is a simple and economical environmental monitoring tool used to monitor air quality. However, routine use of the method is not possible because the protocols involved have not yet been standardized. Some of the most variable methodological aspects include (i) selection of moss species, (ii) ratio of moss weight to surface area of the bag, (iii) duration of exposure, and (iv) height of exposure. In the present study, the best option for each of these aspects was selected on the basis of the mean concentrations and data replicability of Cd, Cu, Hg, Pb and Zn measured during at least two exposure periods in environments affected by different degrees of contamination. The optimal choices for the studied aspects were the following: (i) Sphagnum denticulatum, (ii) 5.68 mg of moss tissue for each cm-2 of bag surface, (iii) 8 weeks of exposure, and (iv) 4 m height of exposure. Duration of exposure and height of exposure accounted for most of the variability in the data. The aim of this methodological study was to provide data to help establish a standardized protocol that will enable use of the moss bag technique by public authorities.

Towards a cognitive robotics methodology for reward-based decision-making: dynamical systems modelling of the Iowa Gambling Task

NASA Astrophysics Data System (ADS)

Lowe, Robert; Ziemke, Tom

2010-09-01

The somatic marker hypothesis (SMH) posits that the role of emotions and mental states in decision-making manifests through bodily responses to stimuli of import to the organism's welfare. The Iowa Gambling Task (IGT), proposed by Bechara and Damasio in the mid-1990s, has provided the major source of empirical validation to the role of somatic markers in the service of flexible and cost-effective decision-making in humans. In recent years the IGT has been the subject of much criticism concerning: (1) whether measures of somatic markers reveal that they are important for decision-making as opposed to behaviour preparation; (2) the underlying neural substrate posited as critical to decision-making of the type relevant to the task; and (3) aspects of the methodological approach used, particularly on the canonical version of the task. In this paper, a cognitive robotics methodology is proposed to explore a dynamical systems approach as it applies to the neural computation of reward-based learning and issues concerning embodiment. This approach is particularly relevant in light of a strongly emerging alternative hypothesis to the SMH, the reversal learning hypothesis, which links, behaviourally and neurocomputationally, a number of more or less complex reward-based decision-making tasks, including the 'A-not-B' task - already subject to dynamical systems investigations with a focus on neural activation dynamics. It is also suggested that the cognitive robotics methodology may be used to extend systematically the IGT benchmark to more naturalised, but nevertheless controlled, settings that might better explore the extent to which the SMH, and somatic states per se, impact on complex decision-making.

Integrated HTA-FMEA/FMECA methodology for the evaluation of robotic system in urology and general surgery.

PubMed

Frosini, Francesco; Miniati, Roberto; Grillone, Saverio; Dori, Fabrizio; Gentili, Guido Biffi; Belardinelli, Andrea

2016-11-14

The following study proposes and tests an integrated methodology involving Health Technology Assessment (HTA) and Failure Modes, Effects and Criticality Analysis (FMECA) for the assessment of specific aspects related to robotic surgery involving safety, process and technology. The integrated methodology consists of the application of specific techniques coming from the HTA joined to the aid of the most typical models from reliability engineering such as FMEA/FMECA. The study has also included in-site data collection and interviews to medical personnel. The total number of robotic procedures included in the analysis was 44: 28 for urology and 16 for general surgery. The main outcomes refer to the comparative evaluation between robotic, laparoscopic and open surgery. Risk analysis and mitigation interventions come from FMECA application. The small sample size available for the study represents an important bias, especially for the clinical outcomes reliability. Despite this, the study seems to confirm the better trend for robotics' surgical times with comparison to the open technique as well as confirming the robotics' clinical benefits in urology. More complex situation is observed for general surgery, where robotics' clinical benefits directly measured are the lowest blood transfusion rate.

Electromyography and the study of sports movements: a review.

PubMed

Clarys, J P; Cabri, J

1993-10-01

Within electromyography (EMG), a particular specialty has been developed wherein the aim is to use EMG for the study of muscular function and co-ordination. This area of research is usually called kinesiological EMG. The general aims of kinesiological EMG are to analyse the function and co-ordination of muscles in different movements and postures, in healthy subjects as well as in the disabled, in skilled actions as well as during training, in humans as well as in animals, under laboratory conditions as well as during daily or vocational activities. This is often done by a combination of electromyographical and kinesiological or biomechanical measurement techniques. Because there are over 400 skeletal muscles in the human body and both irregular and complex involvement of the muscles may occur in neuromuscular diseases and in voluntary occupational or sports movements, it is impossible to sample all of the muscles of the entire body during the performance of complex motor skills. In addition, the measurement of kinesiological EMG in sport and specific field circumstances, such as the track and/or soccer field, the alpine ski slope, the swimming pool and the ice rink, demands a specific technological and methodological approach, adaptable to both the field and the sport circumstances. Sport movement techniques and skills, training approaches and methods, ergonomic verification of the human-machine interaction have, amongst others, a highly specialized muscular activity in common. The knowledge of such muscular action in all its aspects, its evaluation and its feedback should allow for the optimization of movement, of sports materials, of training possibilities and, in the end, of sports performance. Drawing conclusions from a review of the EMG research of 32 sports, covering over 100 different complex skills, including methodological approaches, is an impossible task. We have attempted to set standards concerning the EMG methodology at the beginning of this review. Electromyography and sports is a vast area and a complete review is impossible, as information will be found scattered in many different journals, including those on the sports sciences, ergonomics, biomechanics, applied physiology, in different congress proceedings, and so on. Consequently, many important aspects and possibly important publications may have been omitted from this review.

Methodological Choices in Peer Nomination Research

ERIC Educational Resources Information Center

Cillessen, Antonius H. N.; Marks, Peter E. L.

2017-01-01

Although peer nomination measures have been used by researchers for nearly a century, common methodological practices and rules of thumb (e.g., which variables to measure; use of limited vs. unlimited nomination methods) have continued to develop in recent decades. At the same time, other key aspects of the basic nomination procedure (e.g.,…

Q and you: The application of Q methodology in recreation research

Treesearch

Whitney Ward

2010-01-01

Researchers have used various qualitative and quantitative methods to deal with subjectivity in studying people's recreation experiences. Q methodology has been the most effective approach for analyzing both qualitative and quantitative aspects of experience, including attitudes or perceptions. The method is composed of two main components--Q sorting and Q factor...

"Parents as Partners" in Research and Evaluation: Methodological and Ethical Issues and Solutions.

ERIC Educational Resources Information Center

Wolfendale, Sheila

1999-01-01

This article investigates parents' status within educational research and examines some research paradigms that have been used. A number of inherent methodological and ethical issues are identified and several fundamental aspects are explored. It is argued that researchers should adopt a partnership model for cooperative research on parental…

Project-Based Learning and Rubrics in the Teaching of Power Supplies and Photovoltaic Electricity

ERIC Educational Resources Information Center

Martinez, F.; Herrero, L. C.; de Pablo, S.

2011-01-01

Project-based learning (PBL) and cooperative learning are, in various aspects, very superior education methodologies compared to other traditional ones. They are highly appropriate methodologies for elective courses, as they exert a strong attraction on the students, quite apart from their educational advantages. This paper describes how PBL and…

A Methodology to Obtain Learning Effective Laboratories with Learning Management System Integration

ERIC Educational Resources Information Center

Ruano, Ildefonso; Gamez, Javier; Dormido, Sebastian; Gomez, Juan

2016-01-01

Online laboratories are useful and valuable resources in high education, especially in engineering studies. This work presents a methodology to create effective laboratories for learning that interact with a Learning Management System (LMS) to achieve advanced integration. It is based on pedagogical aspects and considers not only the laboratory…

Appraising the Ethos of Experiential Narratives: Key Aspects of a Methodological Challenge

ERIC Educational Resources Information Center

Conle, Carola; deBeyer, Michael

2009-01-01

In this essay, Carola Conle and Michael deBeyer describe their efforts to find a conceptual approach and methodology for the appraisal of the ethos of experiential narratives presented in a particular curriculum context. The language of "implied authorship," "the patterning of desire," and "friendships offered and received," first introduced by…

Decoding the Disciplines: An Approach to Scientific Thinking

ERIC Educational Resources Information Center

Pinnow, Eleni

2016-01-01

The Decoding the Disciplines methodology aims to teach students to think like experts in discipline-specific tasks. The central aspect of the methodology is to identify a bottleneck in the course content: a particular topic that a substantial number of students struggle to master. The current study compared the efficacy of standard lecture and…

Have Cognitive Diagnostic Models Delivered Their Goods? Some Substantial and Methodological Concerns

ERIC Educational Resources Information Center

Wilhelm, Oliver; Robitzsch, Alexander

2009-01-01

The paper by Rupp and Templin (2008) is an excellent work on the characteristics and features of cognitive diagnostic models (CDM). In this article, the authors comment on some substantial and methodological aspects of this focus paper. They organize their comments by going through issues associated with the terms "cognitive,"…

A Methodological Proposal for Learning Games Selection and Quality Assessment

ERIC Educational Resources Information Center

Dondi, Claudio; Moretti, Michela

2007-01-01

This paper presents a methodological proposal elaborated in the framework of two European projects dealing with game-based learning, both of which have focused on "quality" aspects in order to create suitable tools that support European educators, practitioners and lifelong learners in selecting and assessing learning games for use in…

Thermoregulatory responses in exercising rats: methodological aspects and relevance to human physiology.

PubMed

Wanner, Samuel Penna; Prímola-Gomes, Thales Nicolau; Pires, Washington; Guimarães, Juliana Bohnen; Hudson, Alexandre Sérvulo Ribeiro; Kunstetter, Ana Cançado; Fonseca, Cletiana Gonçalves; Drummond, Lucas Rios; Damasceno, William Coutinho; Teixeira-Coelho, Francisco

2015-01-01

Rats are used worldwide in experiments that aim to investigate the physiological responses induced by a physical exercise session. Changes in body temperature regulation, which may affect both the performance and the health of exercising rats, are evident among these physiological responses. Despite the universal use of rats in biomedical research involving exercise, investigators often overlook important methodological issues that hamper the accurate measurement of clear thermoregulatory responses. Moreover, much debate exists regarding whether the outcome of rat experiments can be extrapolated to human physiology, including thermal physiology. Herein, we described the impact of different exercise intensities, durations and protocols and environmental conditions on running-induced thermoregulatory changes. We focused on treadmill running because this type of exercise allows for precise control of the exercise intensity and the measurement of autonomic thermoeffectors associated with heat production and loss. Some methodological issues regarding rat experiments, such as the sites for body temperature measurements and the time of day at which experiments are performed, were also discussed. In addition, we analyzed the influence of a high body surface area-to-mass ratio and limited evaporative cooling on the exercise-induced thermoregulatory responses of running rats and then compared these responses in rats to those observed in humans. Collectively, the data presented in this review represent a reference source for investigators interested in studying exercise thermoregulation in rats. In addition, the present data indicate that the thermoregulatory responses of exercising rats can be extrapolated, with some important limitations, to human thermal physiology.

Thermoregulatory responses in exercising rats: methodological aspects and relevance to human physiology

PubMed Central

Wanner, Samuel Penna; Prímola-Gomes, Thales Nicolau; Pires, Washington; Guimarães, Juliana Bohnen; Hudson, Alexandre Sérvulo Ribeiro; Kunstetter, Ana Cançado; Fonseca, Cletiana Gonçalves; Drummond, Lucas Rios; Damasceno, William Coutinho; Teixeira-Coelho, Francisco

2015-01-01

Rats are used worldwide in experiments that aim to investigate the physiological responses induced by a physical exercise session. Changes in body temperature regulation, which may affect both the performance and the health of exercising rats, are evident among these physiological responses. Despite the universal use of rats in biomedical research involving exercise, investigators often overlook important methodological issues that hamper the accurate measurement of clear thermoregulatory responses. Moreover, much debate exists regarding whether the outcome of rat experiments can be extrapolated to human physiology, including thermal physiology. Herein, we described the impact of different exercise intensities, durations and protocols and environmental conditions on running-induced thermoregulatory changes. We focused on treadmill running because this type of exercise allows for precise control of the exercise intensity and the measurement of autonomic thermoeffectors associated with heat production and loss. Some methodological issues regarding rat experiments, such as the sites for body temperature measurements and the time of day at which experiments are performed, were also discussed. In addition, we analyzed the influence of a high body surface area-to-mass ratio and limited evaporative cooling on the exercise-induced thermoregulatory responses of running rats and then compared these responses in rats to those observed in humans. Collectively, the data presented in this review represent a reference source for investigators interested in studying exercise thermoregulation in rats. In addition, the present data indicate that the thermoregulatory responses of exercising rats can be extrapolated, with some important limitations, to human thermal physiology. PMID:27227066

Methodological Aspects of Focus Groups in Health Research

PubMed Central

Tausch, Anja P.; Menold, Natalja

2016-01-01

Although focus groups are commonly used in health research to explore the perspectives of patients or health care professionals, few studies consider methodological aspects in this specific context. For this reason, we interviewed nine researchers who had conducted focus groups in the context of a project devoted to the development of an electronic personal health record. We performed qualitative content analysis on the interview data relating to recruitment, communication between the focus group participants, and appraisal of the focus group method. The interview data revealed aspects of the focus group method that are particularly relevant for health research and that should be considered in that context. They include, for example, the preferability of face-to-face recruitment, the necessity to allow participants in patient groups sufficient time to introduce themselves, and the use of methods such as participant-generated cards and prioritization. PMID:28462326

Methodological Aspects of Focus Groups in Health Research: Results of Qualitative Interviews With Focus Group Moderators.

PubMed

Tausch, Anja P; Menold, Natalja

2016-01-01

Although focus groups are commonly used in health research to explore the perspectives of patients or health care professionals, few studies consider methodological aspects in this specific context. For this reason, we interviewed nine researchers who had conducted focus groups in the context of a project devoted to the development of an electronic personal health record. We performed qualitative content analysis on the interview data relating to recruitment, communication between the focus group participants, and appraisal of the focus group method. The interview data revealed aspects of the focus group method that are particularly relevant for health research and that should be considered in that context. They include, for example, the preferability of face-to-face recruitment, the necessity to allow participants in patient groups sufficient time to introduce themselves, and the use of methods such as participant-generated cards and prioritization.

Culture and spirituality: essential components of palliative care.

PubMed

Speck, Peter

2016-06-01

Palliative care advocates a holistic, multiprofessional approach to the care of people with life-threatening disease. In addition to the control of physical symptoms attention should also be paid to psychosocial, cultural and spiritual aspects of the patient's experience of illness. Guidance documents and research evidence reflect the complexity of the patient's journey and the need to regularly assess these areas of need over time. Cultural background can shape how patients respond to life-threatening illness, as can the beliefs held by the patients, whether religious or more broadly spiritual. Research evidence shows the importance of identifying and addressing cultural and spiritual aspects of care held by patients, families and staff. These are often neglected in clinical practice due to the focus on biomedical concerns and staff discomfort in engaging with beliefs and culture. Recent studies have highlighted gaps in the research, and some methodological difficulties and indicate many patients welcome healthcare staff enquiring about the importance of their beliefs and culture. Identifying research priorities is necessary to guide future research and strengthen the evidence base. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Human performance cognitive-behavioral modeling: a benefit for occupational safety.

PubMed

Gore, Brian F

2002-01-01

Human Performance Modeling (HPM) is a computer-aided job analysis software methodology used to generate predictions of complex human-automation integration and system flow patterns with the goal of improving operator and system safety. The use of HPM tools has recently been increasing due to reductions in computational cost, augmentations in the tools' fidelity, and usefulness in the generated output. An examination of an Air Man-machine Integration Design and Analysis System (Air MIDAS) model evaluating complex human-automation integration currently underway at NASA Ames Research Center will highlight the importance to occupational safety of considering both cognitive and physical aspects of performance when researching human error.

Remote Sensing Data Fusion to Detect Illicit Crops and Unauthorized Airstrips

NASA Astrophysics Data System (ADS)

Pena, J. A.; Yumin, T.; Liu, H.; Zhao, B.; Garcia, J. A.; Pinto, J.

2018-04-01

Remote sensing data fusion has been playing a more and more important role in crop planting area monitoring, especially for crop area information acquisition. Multi-temporal data and multi-spectral time series are two major aspects for improving crop identification accuracy. Remote sensing fusion provides high quality multi-spectral and panchromatic images in terms of spectral and spatial information, respectively. In this paper, we take one step further and prove the application of remote sensing data fusion in detecting illicit crop through LSMM, GOBIA, and MCE analyzing of strategic information. This methodology emerges as a complementary and effective strategy to control and eradicate illicit crops.

Ribosome profiling reveals the what, when, where and how of protein synthesis.

PubMed

Brar, Gloria A; Weissman, Jonathan S

2015-11-01

Ribosome profiling, which involves the deep sequencing of ribosome-protected mRNA fragments, is a powerful tool for globally monitoring translation in vivo. The method has facilitated discovery of the regulation of gene expression underlying diverse and complex biological processes, of important aspects of the mechanism of protein synthesis, and even of new proteins, by providing a systematic approach for experimental annotation of coding regions. Here, we introduce the methodology of ribosome profiling and discuss examples in which this approach has been a key factor in guiding biological discovery, including its prominent role in identifying thousands of novel translated short open reading frames and alternative translation products.

Skin microcirculation and vasopressin infusion: a laser Doppler study

PubMed Central

Bernard, Francis; Vinet, Alain; Verdant, Colin

2006-01-01

Use of arginine vasopressin in the management of refractory vasodilatory shock has been associated with development of ischaemic skin lesions. Because of the increasing popularity of arginine vasopressin, it is important to evaluate its effects on microcirculatory blood flow. Such studies are crucial if we are to appreciate the microcirculatory consequences of our various resuscitation strategies. However, methodological issues must always be considered because they can significantly influence interpretation of the results. Some aspects of use of laser Doppler to evaluate the microcirculation are reviewed within the context of recent findings presented by Luckner and coworkers in this issue of Critical Care. PMID:16594988

Methodology for automating software systems

NASA Technical Reports Server (NTRS)

Moseley, Warren

1990-01-01

Applying ITS technology to the shuttle diagnostics would not require the rigor of the Petri Net representation, however it is important in providing the animated simulated portion of the interface and the demands placed on the system to support the training aspects to have a homogeneous and consistent underlying knowledge representation. By keeping the diagnostic rule base, the hardware description, the software description, user profiles, desired behavioral knowledge, and the user interface in the same notation, it is possible to reason about the all of the properties of petri nets, on any selected portion of the simulation. This reasoning provides foundation for utilization of intelligent tutoring systems technology.

Human performance cognitive-behavioral modeling: a benefit for occupational safety

NASA Technical Reports Server (NTRS)

Gore, Brian F.

2002-01-01

Human Performance Modeling (HPM) is a computer-aided job analysis software methodology used to generate predictions of complex human-automation integration and system flow patterns with the goal of improving operator and system safety. The use of HPM tools has recently been increasing due to reductions in computational cost, augmentations in the tools' fidelity, and usefulness in the generated output. An examination of an Air Man-machine Integration Design and Analysis System (Air MIDAS) model evaluating complex human-automation integration currently underway at NASA Ames Research Center will highlight the importance to occupational safety of considering both cognitive and physical aspects of performance when researching human error.

Performance-costs evaluation for urban storm drainage.

PubMed

Baptista, M; Barraud, S; Alfakih, E; Nascimento, N; Fernandes, W; Moura, P; Castro, L

2005-01-01

The design process of urban stormwater systems incorporating BMPs involves more complexity unlike the design of classic drainage systems for which just the technique of pipes is likely to be used. This paper presents a simple decision aid methodology and an associated software (AvDren) concerning urban stormwater systems, devoted to the evaluation and the comparison of drainage scenarios using BMPs according to different technical, sanitary, social environmental and economical aspects. This kind of tool is particularly interesting so as to help the decision makers to select the appropriate alternative and to plan the investments especially for developing countries, with important sanitary problems and severe budget restrictions.

Application of experimental design in geothermal resources assessment of Ciwidey-Patuha, West Java, Indonesia

NASA Astrophysics Data System (ADS)

Ashat, Ali; Pratama, Heru Berian

2017-12-01

The successful Ciwidey-Patuha geothermal field size assessment required integration data analysis of all aspects to determined optimum capacity to be installed. Resources assessment involve significant uncertainty of subsurface information and multiple development scenarios from these field. Therefore, this paper applied the application of experimental design approach to the geothermal numerical simulation of Ciwidey-Patuha to generate probabilistic resource assessment result. This process assesses the impact of evaluated parameters affecting resources and interacting between these parameters. This methodology have been successfully estimated the maximum resources with polynomial function covering the entire range of possible values of important reservoir parameters.

Evaluating science return in space exploration initiative architectures

NASA Technical Reports Server (NTRS)

Budden, Nancy Ann; Spudis, Paul D.

1993-01-01

Science is an important aspect of the Space Exploration Initiative, a program to explore the Moon and Mars with people and machines. Different SEI mission architectures are evaluated on the basis of three variables: access (to the planet's surface), capability (including number of crew, equipment, and supporting infrastructure), and time (being the total number of man-hours available for scientific activities). This technique allows us to estimate the scientific return to be expected from different architectures and from different implementations of the same architecture. Our methodology allows us to maximize the scientific return from the initiative by illuminating the different emphases and returns that result from the alternative architectural decisions.

Compliance and Cognitive Function: A Methodological Approach to Measuring Unintentional Errors in Medication Compliance in the Elderly.

ERIC Educational Resources Information Center

Isaac, Lisa M.; And Others

1993-01-01

Assessed multiple aspects of cognitive performance, medication planning ability, and medication compliance in 20 elderly outpatients. Findings suggest that aspects of attention/concentration, visual and verbal memory, and motor function which are untapped by simple mental status assessment are related to medication access, planning, and compliance…

The Interdisciplinary Course in the Legal Aspects of Noise Pollution at Columbia University.

ERIC Educational Resources Information Center

Harris, Cyril M.; Rosenthal, Albert J.

1981-01-01

A course in the legal aspects of noise pollution, cross-listed for students in Columbia University's Law and Engineering Schools, is described. Although noise is used as the major source of environmental pollution in this course, the principles and methodology discussed apply to other forms of environmental law. (MLW)

Proceedings of the European Conference on Research in Rehabilitation (Second, Duesseldorf, West Germany, November 18-19, 1985).

ERIC Educational Resources Information Center

Roth, Helga, Ed.

1987-01-01

These conference proceedings deal with an interdisciplinary approach to reducing handicapping conditions and ensuring integration of and equal participation by people with disabilities in all aspects of community life. Papers from plenary sessions cover such topics as psychological and social aspects of rehabilitation, research methodology in…

The colloquial approach: An active learning technique

NASA Astrophysics Data System (ADS)

Arce, Pedro

1994-09-01

This paper addresses the very important problem of the effectiveness of teaching methodologies in fundamental engineering courses such as transport phenomena. An active learning strategy, termed the colloquial approach, is proposed in order to increase student involvement in the learning process. This methodology is a considerable departure from traditional methods that use solo lecturing. It is based on guided discussions, and it promotes student understanding of new concepts by directing the student to construct new ideas by building upon the current knowledge and by focusing on key cases that capture the essential aspects of new concepts. The colloquial approach motivates the student to participate in discussions, to develop detailed notes, and to design (or construct) his or her own explanation for a given problem. This paper discusses the main features of the colloquial approach within the framework of other current and previous techniques. Problem-solving strategies and the need for new textbooks and for future investigations based on the colloquial approach are also outlined.

Some methodological aspects of tectonic stress reconstruction based on geological indicators

NASA Astrophysics Data System (ADS)

Sim, Lidiya A.

2012-03-01

The impact of the initial heterogeneity in rocks on the distribution of slickensides (slip planes), which are used to reconstruct local stress-state, is discussed. The stress-state was reconstructed by a graphic variant of the cinematic method. A new type of stress-state - Variation of Stress-State Type (VSST) - is introduced. The VSST is characterized by dislocation vectors originated both by uniaxial compression and uniaxial tension in the same rock volume, i.e. coefficient μσ = 1-2R varies from +1 to -1. The reasons for differences between slip planes from those predicted by the model are discussed. The distribution of slip planes depends on the stress-state type (μσ coefficient) and on the initial heterogeneity of the rocks. A criterion for the identification of tectonic stress rank is suggested. It is based on the models of tectonic stress distribution in the fracture vicinities. Examples of results of tectonic stress studies are given. Studies of tectonic stresses based on geological indicators are of methodological and practical importance.

Parallel and Perpendicular Alignment of Anisotropic Particles in Free Liquid Microjets and Emerging Microdroplets.

PubMed

Schlenk, Mathias; Hofmann, Eddie; Seibt, Susanne; Rosenfeldt, Sabine; Schrack, Lukas; Drechsler, Markus; Rothkirch, Andre; Ohm, Wiebke; Breu, Josef; Gekle, Stephan; Förster, Stephan

2018-04-24

Liquid microjets play a key role in fiber spinning, inkjet printing, and coating processes. In all of these applications, the liquid jets carry dispersed particles whose spatial and orientational distributions within the jet critically influence the properties of the fabricated structures. Despite its importance, there is currently no knowledge about the orientational distribution of particles within microjets and droplets. Here, we demonstrate a microfluidic device that allows to determine the local particle distribution and orientation by X-ray scattering. Using this methodology, we discovered unexpected changes in the particle orientation upon exiting the nozzle to form a free jet, and upon jet break-up into droplets, causing an unusual biaxial particle orientation. We show how flow and aspect ratio determine the flow orientation of anisotropic particles. Furthermore, we demonstrate that the observed phenomena are a general characteristic of anisotropic particles. Our findings greatly enhance our understanding of particle orientation in free jets and droplets and provide a rationale for controlling particle alignment in liquid jet-based fabrication methodologies.

Optical characterization of agricultural pest insects: a methodological study in the spectral and time domains

NASA Astrophysics Data System (ADS)

Li, Y. Y.; Zhang, H.; Duan, Z.; Lian, M.; Zhao, G. Y.; Sun, X. H.; Hu, J. D.; Gao, L. N.; Feng, H. Q.; Svanberg, S.

2016-08-01

Identification of agricultural pest insects is an important aspect in insect research and agricultural monitoring. We have performed a methodological study of how spectroscopic techniques and wing-beat frequency analysis might provide relevant information. An optical system based on the combination of close-range remote sensing and reflectance spectroscopy was developed to study the optical characteristics of different flying insects, collected in Southern China. The results demonstrate that the combination of wing-beat frequency assessment and reflectance spectral analysis has the potential to successfully differentiate between insect species. Further, studies of spectroscopic characteristics of fixed specimen of insects, also from Central China, showed the possibility of refined agricultural pest identification. Here, in addition to reflectance recordings also laser-induced fluorescence spectra were investigated for all the species of insects under study and found to provide complementary information to optically distinguish insects. In order to prove the practicality of the techniques explored, clearly fieldwork aiming at elucidating the variability of parameters, even within species, must be performed.

Relationship between perceived politeness and spectral characteristics of voice

NASA Astrophysics Data System (ADS)

Ito, Mika

2005-04-01

This study investigates the role of voice quality in perceiving politeness under conditions of varying relative social status among Japanese male speakers. The work focuses on four important methodological issues: experimental control of sociolinguistic aspects, eliciting natural spontaneous speech, obtaining recording quality suitable for voice quality analysis, and assessment of glottal characteristics through the use of non-invasive direct measurements of the speech spectrum. To obtain natural, unscripted utterances, the speech data were collected with a Map Task. This methodology allowed us to study the effect of manipulating relative social status among participants in the same community. We then computed the relative amplitudes of harmonics and formant peaks in spectra obtained from the Map Task recordings. Finally, an experiment was conducted to observe the alignment between acoustic measures and the perceived politeness of the voice samples. The results suggest that listeners' perceptions of politeness are determined by spectral characteristics of speakers, in particular, spectral tilts obtained by computing the difference in amplitude between the first harmonic and the third formant.

Support vector machine firefly algorithm based optimization of lens system.

PubMed

Shamshirband, Shahaboddin; Petković, Dalibor; Pavlović, Nenad T; Ch, Sudheer; Altameem, Torki A; Gani, Abdullah

2015-01-01

Lens system design is an important factor in image quality. The main aspect of the lens system design methodology is the optimization procedure. Since optimization is a complex, nonlinear task, soft computing optimization algorithms can be used. There are many tools that can be employed to measure optical performance, but the spot diagram is the most useful. The spot diagram gives an indication of the image of a point object. In this paper, the spot size radius is considered an optimization criterion. Intelligent soft computing scheme support vector machines (SVMs) coupled with the firefly algorithm (FFA) are implemented. The performance of the proposed estimators is confirmed with the simulation results. The result of the proposed SVM-FFA model has been compared with support vector regression (SVR), artificial neural networks, and generic programming methods. The results show that the SVM-FFA model performs more accurately than the other methodologies. Therefore, SVM-FFA can be used as an efficient soft computing technique in the optimization of lens system designs.

A methodology to quantify the release of spent nuclear fuel from dry casks during security-related scenarios

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durbin, Samuel G.; Luna, Robert Earl

Assessing the risk to the public and the environment from a release of radioactive material produced by accidental or purposeful forces/environments is an important aspect of the regulatory process in many facets of the nuclear industry. In particular, the transport and storage of radioactive materials is of particular concern to the public, especially with regard to potential sabotage acts that might be undertaken by terror groups to cause injuries, panic, and/or economic consequences to a nation. For many such postulated attacks, no breach in the robust cask or storage module containment is expected to occur. However, there exists evidence thatmore » some hypothetical attack modes can penetrate and cause a release of radioactive material. This report is intended as an unclassified overview of the methodology for release estimation as well as a guide to useful resource data from unclassified sources and relevant analysis methods for the estimation process.« less

Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN.

PubMed

Ugalde-Olano, Aitziber; Egia, Ainara; Fernández-Ruiz, Sonia; Loizaga-Iriarte, Ana; Zuñiga-García, Patricia; Garcia, Stephane; Royo, Félix; Lacasa-Viscasillas, Isabel; Castro, Erika; Cortazar, Ana R; Zabala-Letona, Amaia; Martín-Martín, Natalia; Arruabarrena-Aristorena, Amaia; Torrano-Moya, Verónica; Valcárcel-Jiménez, Lorea; Sánchez-Mosquera, Pilar; Caro-Maldonado, Alfredo; González-Tampan, Jorge; Cachi-Fuentes, Guido; Bilbao, Elena; Montero, Rocío; Fernández, Sara; Arrieta, Edurne; Zorroza, Kerman; Castillo-Martín, Mireia; Serra, Violeta; Salazar, Eider; Macías-Cámara, Nuria; Tabernero, Jose; Baselga, Jose; Cordón-Cardo, Carlos; Aransay, Ana M; Villar, Amaia Del; Iovanna, Juan L; Falcón-Pérez, Juan M; Unda, Miguel; Bilbao, Roberto; Carracedo, Arkaitz

2015-05-01

Prostate cancer is among the most frequent cancers in men, and despite its high rate of cure, the high number of cases results in an elevated mortality worldwide. Importantly, prostate cancer incidence is dramatically increasing in western societies in the past decades, suggesting that this type of tumor is exquisitely sensitive to lifestyle changes. Prostate cancer frequently exhibits alterations in the PTEN gene (inactivating mutations or gene deletions) or at the protein level (reduced protein expression or altered sub-cellular compartmentalization). The relevance of PTEN in this type of cancer is further supported by the fact that the sole deletion of PTEN in the murine prostate epithelium recapitulates many of the features of the human disease. In order to study the molecular alterations in prostate cancer, we need to overcome the methodological challenges that this tissue imposes. In this review we present protocols and methods, using PTEN as proof of concept, to study different molecular characteristics of prostate cancer. Copyright © 2015. Published by Elsevier Inc.

Cost accounting models used for price-setting of health services: an international review.

PubMed

Raulinajtys-Grzybek, Monika

2014-12-01

The aim of the article was to present and compare cost accounting models which are used in the area of healthcare for pricing purposes in different countries. Cost information generated by hospitals is further used by regulatory bodies for setting or updating prices of public health services. The article presents a set of examples from different countries of the European Union, Australia and the United States and concentrates on DRG-based payment systems as they primarily use cost information for pricing. Differences between countries concern the methodology used, as well as the data collection process and the scope of the regulations on cost accounting. The article indicates that the accuracy of the calculation is only one of the factors that determine the choice of the cost accounting methodology. Important aspects are also the selection of the reference hospitals, precise and detailed regulations and the existence of complex healthcare information systems in hospitals. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

The assessment of aesthetic and perceptual aspects within environmental impact assessment of renewable energy projects in Italy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tolli, Michela, E-mail: michela.tolli@uniroma1.it; Recanatesi, Fabio, E-mail: fabio.rec@unitus.it; Piccinno, Matteo

The main aim of this paper is to explore how perceptual and aesthetic impact analyses are considered in Environmental Impact Assessment (EIA), with specific reference to Italian renewable energy projects. To investigate this topic, the paper starts by establishing which factors are linked with perceptual and aesthetic impacts and why it is important to analyze these aspects, which are also related to legislative provisions and procedures in Europe and in Italy. In particular the paper refers to renewable energy projects because environmental policies are encouraging more and more investment in this kind of primary resource. The growing interest in thismore » type of energy is leading to the realization of projects which change the governance of territories, with inevitable effects on the landscape from the aesthetic and perceptual points of view. Legislative references to EIA, including the latest directive regarding this topic show the importance of integrating the assessment of environmental and perceptual impacts, thus there is a need to improve EIA methodological approaches to this purpose. This paper proposes a profile of aesthetic and perceptual impact analysis in EIA for renewable energy projects in Italy, and concludes with recommendations as to how this kind of analysis could be improved. - Highlights: • We analyze 29 EIA Reports of Italian renewable energy projects. • We examine esthetic and perceptual aspects present in Italian EIA reports. • We identified inconsistency in use of methods for esthetic and perceptual aspects. • Local populations are rarely included as stakeholders in EIAs. • A shared understanding of perceptual and esthetic issues in EIA proceedings is required.« less

[Quality of clinical studies published in the RBGO over one decade (1999-2009): methodological and ethical aspects and statistical procedures].

PubMed

de Sá, Joceline Cássia Ferezini; Marini, Gabriela; Gelaleti, Rafael Bottaro; da Silva, João Batista; de Azevedo, George Gantas; Rudge, Marilza Vieira Cunha

2013-11-01

To evaluate the methodological and statistical design evolution of the publications in the Brazilian Journal of Gynecology and Obstetrics (RBGO) from resolution 196/96. A review of 133 articles published in 1999 (65) and 2009 (68) was performed by two independent reviewers with training in clinical epidemiology and methodology of scientific research. We included all original clinical articles, case and series reports and excluded editorials, letters to the editor, systematic reviews, experimental studies, opinion articles, besides abstracts of theses and dissertations. Characteristics related to the methodological quality of the studies were analyzed in each article using a checklist that evaluated two criteria: methodological aspects and statistical procedures. We used descriptive statistics and the χ2 test for comparison of the two years. There was a difference between 1999 and 2009 regarding the study and statistical design, with more accuracy in the procedures and the use of more robust tests between 1999 and 2009. In RBGO, we observed an evolution in the methods of published articles and a more in-depth use of the statistical analyses, with more sophisticated tests such as regression and multilevel analyses, which are essential techniques for the knowledge and planning of health interventions, leading to fewer interpretation errors.

Cross-Continental Comparison of National Food Consumption Survey Methods—A Narrative Review

PubMed Central

De Keyzer, Willem; Bracke, Tatiana; McNaughton, Sarah A.; Parnell, Winsome; Moshfegh, Alanna J.; Pereira, Rosangela A.; Lee, Haeng-Shin; van’t Veer, Pieter; De Henauw, Stefaan; Huybrechts, Inge

2015-01-01

Food consumption surveys are performed in many countries. Comparison of results from those surveys across nations is difficult because of differences in methodological approaches. While consensus about the preferred methodology associated with national food consumption surveys is increasing, no inventory of methodological aspects across continents is available. The aims of the present review are (1) to develop a framework of key methodological elements related to national food consumption surveys, (2) to create an inventory of these properties of surveys performed in the continents North-America, South-America, Asia and Australasia, and (3) to discuss and compare these methodological properties cross-continentally. A literature search was performed using a fixed set of search terms in different databases. The inventory was completed with all accessible information from all retrieved publications and corresponding authors were requested to provide additional information where missing. Surveys from ten individual countries, originating from four continents are listed in the inventory. The results are presented according to six major aspects of food consumption surveys. The most common dietary intake assessment method used in food consumption surveys worldwide is the 24-HDR (24 h dietary recall), occasionally administered repeatedly, mostly using interview software. Only three countries have incorporated their national food consumption surveys into continuous national health and nutrition examination surveys. PMID:25984745

Risk of bias and methodological issues in randomised controlled trials of acupuncture for knee osteoarthritis: a cross-sectional study.

PubMed

Jia, Pengli; Tang, Li; Yu, Jiajie; Lee, Andy H; Zhou, Xu; Kang, Deying; Luo, Yanan; Liu, Jiali; Sun, Xin

2018-03-06

To assess risk of bias and to investigate methodological issues concerning the design, conduct and analysis of randomised controlled trials (RCTs) testing acupuncture for knee osteoarthritis (KOA). PubMed, EMBASE, Cochrane Central Register of Controlled Trials and four major Chinese databases were searched for RCTs that investigated the effect of acupuncture for KOA. The Cochrane tool was used to examine the risk of bias of eligible RCTs. Their methodological details were examined using a standardised and pilot-tested questionnaire of 48 items, together with the association between four predefined factors and important methodological quality indicators. A total of 248 RCTs were eligible, of which 39 (15.7%) used computer-generated randomisation sequence. Of the 31 (12.5%) trials that stated the allocation concealment, only one used central randomisation. Twenty-five (10.1%) trials mentioned that their acupuncture procedures were standardised, but only 18 (7.3%) specified how the standardisation was achieved. The great majority of trials (n=233, 94%) stated that blinding was in place, but 204 (87.6%) did not clarify who was blinded. Only 27 (10.9%) trials specified the primary outcome, for which 7 used intention-to-treat analysis. Only 17 (6.9%) trials included details on sample size calculation; none preplanned an interim analysis and associated stopping rule. In total, 46 (18.5%) trials explicitly stated that loss to follow-up occurred, but only 6 (2.4%) provided some information to deal with the issue. No trials prespecified, conducted or reported any subgroup or adjusted analysis for the primary outcome. The overall risk of bias was high among published RCTs testing acupuncture for KOA. Methodological limitations were present in many important aspects of design, conduct and analyses. These findings inform the development of evidence-based methodological guidance for future trials assessing the effect of acupuncture for KOA. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

A Digital Ecosystem for the Collaborative Production of Open Textbooks: The LATIn Methodology

ERIC Educational Resources Information Center

Silveira, Ismar Frango; Ochôa, Xavier; Cuadros-Vargas, Alex; Pérez Casas, Alén; Casali, Ana; Ortega, Andre; Sprock, Antonio Silva; Alves, Carlos Henrique; Collazos Ordoñez, Cesar Alberto; Deco, Claudia; Cuadros-Vargas, Ernesto; Knihs, Everton; Parra, Gonzalo; Muñoz-Arteaga, Jaime; Gomes dos Santos, Jéssica; Broisin, Julien; Omar, Nizam; Motz, Regina; Rodés, Virginia; Bieliukas, Yosly Hernández C.

2013-01-01

Access to books in higher education is an issue to be addressed, especially in the context of underdeveloped countries, such as those in Latin America. More than just financial issues, cultural aspects and need for adaptation must be considered. The present conceptual paper proposes a methodology framework that would support collaborative open…

Didactic Aspects of the Academic Discipline "History and Methodology of Mathematics"

ERIC Educational Resources Information Center

Sun, Hai; Varankina, Vera I.; Sadovaya, Victoriya V.

2017-01-01

The purpose of this article is to develop the content and methods, as well as the analysis of the approbation of the program of the academic discipline "History and methodology of mathematics" for graduate students of the Master's program of mathematical program tracks. The leading method in the study of this problem was the method of…

Methodology of Comparative Analysis of Public School Teachers' Continuing Professional Development in Great Britain, Canada and the USA

ERIC Educational Resources Information Center

Mukan, Nataliya; Kravets, Svitlana

2015-01-01

In the article the methodology of comparative analysis of public school teachers' continuing professional development (CPD) in Great Britain, Canada and the USA has been presented. The main objectives are defined as theoretical analysis of scientific and pedagogical literature, which highlights different aspects of the problem under research;…

Automated sleep stage detection with a classical and a neural learning algorithm--methodological aspects.

PubMed

Schwaibold, M; Schöchlin, J; Bolz, A

2002-01-01

For classification tasks in biosignal processing, several strategies and algorithms can be used. Knowledge-based systems allow prior knowledge about the decision process to be integrated, both by the developer and by self-learning capabilities. For the classification stages in a sleep stage detection framework, three inference strategies were compared regarding their specific strengths: a classical signal processing approach, artificial neural networks and neuro-fuzzy systems. Methodological aspects were assessed to attain optimum performance and maximum transparency for the user. Due to their effective and robust learning behavior, artificial neural networks could be recommended for pattern recognition, while neuro-fuzzy systems performed best for the processing of contextual information.

[Methodological aspects in the evaluation of turn-over and up/down sizing as indicators of work-related stress].

PubMed

Veronesi, G; Bertù, L; Mombelli, S; Cimmino, L; Caravati, G; Conti, M; Abate, T; Ferrario, M M

2011-01-01

We discuss the methodological aspects related to the evaluation of turn-over and up-down sizing as indicators of work-related stress, in complex organizations like a university hospital. To estimate the active workers population we developed an algorithm which integrated several administrative databases. The indicators were standardized to take into account some potential confounders (age, sex, work seniority) when considering different hospital structures and job mansions. Main advantages of our method include flexibility in the choice of the analysis detail (hospital units, job mansions, a combination of both) and the possibility to describe over-time trends to measure the success of preventive strategies.

An integrated methodology to assess the benefits of urban green space.

PubMed

De Ridder, K; Adamec, V; Bañuelos, A; Bruse, M; Bürger, M; Damsgaard, O; Dufek, J; Hirsch, J; Lefebre, F; Pérez-Lacorzana, J M; Thierry, A; Weber, C

2004-12-01

The interrelated issues of urban sprawl, traffic congestion, noise, and air pollution are major socioeconomic problems faced by most European cities. A methodology is currently being developed for evaluating the role of green space and urban form in alleviating the adverse effects of urbanisation, mainly focusing on the environment but also accounting for socioeconomic aspects. The objectives and structure of the methodology are briefly outlined and illustrated with preliminary results obtained from case studies performed on several European cities.

Methodological reporting of randomized controlled trials in major hepato-gastroenterology journals in 2008 and 1998: a comparative study

PubMed Central

2011-01-01

Background It was still unclear whether the methodological reporting quality of randomized controlled trials (RCTs) in major hepato-gastroenterology journals improved after the Consolidated Standards of Reporting Trials (CONSORT) Statement was revised in 2001. Methods RCTs in five major hepato-gastroenterology journals published in 1998 or 2008 were retrieved from MEDLINE using a high sensitivity search method and their reporting quality of methodological details were evaluated based on the CONSORT Statement and Cochrane Handbook for Systematic Reviews of interventions. Changes of the methodological reporting quality between 2008 and 1998 were calculated by risk ratios with 95% confidence intervals. Results A total of 107 RCTs published in 2008 and 99 RCTs published in 1998 were found. Compared to those in 1998, the proportion of RCTs that reported sequence generation (RR, 5.70; 95%CI 3.11-10.42), allocation concealment (RR, 4.08; 95%CI 2.25-7.39), sample size calculation (RR, 3.83; 95%CI 2.10-6.98), incomplete outecome data addressed (RR, 1.81; 95%CI, 1.03-3.17), intention-to-treat analyses (RR, 3.04; 95%CI 1.72-5.39) increased in 2008. Blinding and intent-to-treat analysis were reported better in multi-center trials than in single-center trials. The reporting of allocation concealment and blinding were better in industry-sponsored trials than in public-funded trials. Compared with historical studies, the methodological reporting quality improved with time. Conclusion Although the reporting of several important methodological aspects improved in 2008 compared with those published in 1998, which may indicate the researchers had increased awareness of and compliance with the revised CONSORT statement, some items were still reported badly. There is much room for future improvement. PMID:21801429

Explorers of the Universe: Metacognitive Tools for Learning Science Concepts

NASA Technical Reports Server (NTRS)

Alvarez, Marino C.

1998-01-01

Much of school learning consists of rote memorization of facts with little emphasis on meaningful interpretations. Knowledge construction is reduced to factual knowledge production with little regard for critical thinking, problem solving, or clarifying misconceptions. An important role of a middle and secondary teacher when teaching science is to aid students' ability to reflect upon what they know about a given topic and make available strategies that will enhance their understanding of text and science experiments. Developing metacognition, the ability to monitor one's own knowledge about a topic of study and to activate appropriate strategies, enhances students' learning when faced with reading, writing and problem solving situations. Two instructional strategies that can involve students in developing metacognitive awareness are hierarchical concept mapping, and Vee diagrams. Concept maps enable students to organize their ideas and reveal visually these ideas to others. A Vee diagram is a structured visual means of relating the methodological aspects of an activity to its underlying conceptual aspect in ways that aid learners in meaningful understanding of scientific investigations.

Toward youth self-report of health and quality of life in population monitoring.

PubMed

Topolski, Tari D; Edwards, Todd C; Patrick, Donald L

2004-01-01

This paper addresses population monitoring of youth health and quality of life, including the concepts used, methodological and practical criteria for indicators, and existing surveys and measures. Current population surveys of youth generally focus on poor health, such as disability or health-risk behaviors. Although these are important end points, indicators of illness or risk do not reflect the health or life perspective of the majority of youth who do not experience health problems. The measures used to monitor youth health should be appropriate and sensitive to future needs and capture the perspectives of youths. Two potential concepts for this "scorecard" are self-perceived health and quality of life, which have been shown to be useful in adults. For youth, the quality of life framework seems particularly relevant as it incorporates both positive and negative aspects of health and well-being and also captures salient aspects of health other than physical health, such as sense of self, social relationships, environment and culture, and life satisfaction.

Issues with data and analyses: Errors, underlying themes, and potential solutions

PubMed Central

Allison, David B.

2018-01-01

Some aspects of science, taken at the broadest level, are universal in empirical research. These include collecting, analyzing, and reporting data. In each of these aspects, errors can and do occur. In this work, we first discuss the importance of focusing on statistical and data errors to continually improve the practice of science. We then describe underlying themes of the types of errors and postulate contributing factors. To do so, we describe a case series of relatively severe data and statistical errors coupled with surveys of some types of errors to better characterize the magnitude, frequency, and trends. Having examined these errors, we then discuss the consequences of specific errors or classes of errors. Finally, given the extracted themes, we discuss methodological, cultural, and system-level approaches to reducing the frequency of commonly observed errors. These approaches will plausibly contribute to the self-critical, self-correcting, ever-evolving practice of science, and ultimately to furthering knowledge. PMID:29531079

The current state of clinical ethics and healthcare ethics committees in Belgium

PubMed Central

Meulenbergs, T; Vermylen, J; Schotsmans, P

2005-01-01

Ethics committees are the most important practical instrument of clinical ethics in Belgium and fulfil three tasks: the ethical review of experimental protocols, advising on the ethical aspects of healthcare practice, and ethics consultation. In this article the authors examine the current situation of ethics committees in Belgium from the perspective of clinical ethics. Firstly, the most important steps which thus far have been taken in Belgium are examined. Secondly, recent opinion by the Belgian Advisory Committee on Bioethics with regard to ethics committees is presented and the activities of Belgian ethics committees are discussed. Finally, the option to bring research ethics and clinical ethics under the roof of just one committee is criticised using a pragmatic and a methodological argument. Concomitantly, the authors build an argument in favour of the further development of ethics consultation. PMID:15923477

Comment on "Most computational hydrology is not reproducible, so is it really science?" by Christopher Hutton et al.

NASA Astrophysics Data System (ADS)

Añel, Juan A.

2017-03-01

Nowadays, the majority of the scientific community is not aware of the risks and problems associated with an inadequate use of computer systems for research, mostly for reproducibility of scientific results. Such reproducibility can be compromised by the lack of clear standards and insufficient methodological description of the computational details involved in an experiment. In addition, the inappropriate application or ignorance of copyright laws can have undesirable effects on access to aspects of great importance of the design of experiments and therefore to the interpretation of results.