Hybrid Rocket Experiment Station for Capstone Design

NASA Technical Reports Server (NTRS)

Conley, Edgar; Hull, Bethanne J.

2012-01-01

Portable hybrid rocket motors and test stands can be seen in many papers but none have been reported on the design or instrumentation at such a small magnitude. The design of this hybrid rocket and test stand is to be small and portable (suitcase size). This basic apparatus will be used for demonstrations in rocket propulsion. The design had to include all of the needed hardware to operate the hybrid rocket unit (with the exception of the external Oxygen tank). The design of this project includes making the correlation between the rocket's thrust and its size, the appropriate transducers (physical size, resolution, range, and cost), compatability with a laptop analog card, the ease of setup, and its portability.

Photovoltaics and solar thermal conversion to electricity - Status and prospects

NASA Technical Reports Server (NTRS)

Alper, M. E.

1979-01-01

Photovoltaic power system technology development includes flat-plate silicon solar arrays and concentrating solar cell systems, which use silicon and other cell materials such as gallium arsenide. System designs and applications include small remote power systems ranging in size from tens of watts to tens of kilowatts, intermediate load-center applications ranging in size from tens to hundreds of kilowatts, and large central plant installations, as well as grid-connected rooftop applications. The thermal conversion program is concerned with large central power systems and small power applications.

Scanning systems for particle cancer therapy

DOEpatents

Trbojevic, Dejan

2015-08-04

A particle beam to treat malignant tissue is delivered to a patient by a gantry. The gantry includes a plurality of small magnets sequentially arranged along a beam tube to transfer the particle beam with strong focusing and a small dispersion function, whereby a beam size is very small, allowing for the small magnet size. Magnets arranged along the beam tube uses combined function magnets where the magnetic field is a combination of a bending dipole field with a focusing or defocusing quadrupole field. A triplet set of combined function magnets defines the beam size at the patient. A scanning system of magnets arranged along the beam tube after the bending system delivers the particle beam in a direction normal to the patient, to minimize healthy skin and tissue exposure to the particle beam.

Pilot application study of corridor performance indicators

DOT National Transportation Integrated Search

1998-09-16

The need for effective multimodal performance indicators (or measures) is becoming increasingly important for adequate planning in all sizes of transportation environments, including small and medium-size communities. These measures are essential for...

Small renal size in newborns with spina bifida: possible causes.

PubMed

Montaldo, Paolo; Montaldo, Luisa; Iossa, Azzurra Concetta; Cennamo, Marina; Caredda, Elisabetta; Del Gado, Roberto

2014-02-01

Previous studies reported that children with neural tube defects, but without any history of intrinsic renal diseases, have small kidneys when compared with age-matched standard renal growth. The aim of this study was to investigate the possible causes of small renal size in children with spina bifida by comparing growth hormone deficiency, physical limitations and hyperhomocysteinemia. The sample included 187 newborns with spina bifida. Renal sizes in the patients were assessed by using maximum measurement of renal length and the measurements were compared by using the Sutherland monogram. According to the results, the sample was divided into two groups--a group of 120 patients with small kidneys (under the third percentile) and a control group of 67 newborns with normal kidney size. Plasma total homocysteine was investigated in mothers and in their children. Serum insulin-like growth factor-1 (IGF-1) levels were measured. Serum IGF-1 levels were normal in both groups. Children and mothers with homocysteine levels >10 μmol/l were more than twice as likely to have small kidneys and to give to birth children with small kidneys, respectively, compared with newborns and mothers with homocysteine levels <10 μmol/l. An inverse correlation was also found between the homocysteine levels of mothers and kidney sizes of children (r = - 0.6109 P ≤ 0.01). It is highly important for mothers with hyperhomocysteinemia to be educated about benefits of folate supplementation in order to reduce the risk of small renal size and lower renal function in children.

[Management of cerebrospinal fluid leaks according to size. Our experience].

PubMed

Alobid, Isam; Enseñat, Joaquim; Rioja, Elena; Enriquez, Karla; Viscovich, Liza; de Notaris, Matteo; Bernal-Sprekelsen, Manuel

2014-01-01

We present our experience in the reconstruction of cerebrospinal fluid (CSF) leaks according to their size and location. Fifty-four patients who underwent advanced skull base surgery (large defects) and 62 patients with CSF leaks of different origin (small and medium-sized defects) were included. Large defects were reconstructed with a nasoseptal pedicled flap positioned on fat and fascia lata and lumbar drainage was used. In small and medium-sized leaks of other origin, intrathecal fluorescein 5% was applied previously to identify the defect. Fascia lata in an underlay position was used for reconstruction, which was then covered with mucoperiosteum from the turbinate. Perioperative antibiotics were administered for 5-7 days. Nasal packing was removed after 24-48 hours. The most frequent aetiology for small and medium-sized defects was spontaneous (48.4%), followed by trauma (24.2%), iatrogenic (5%) and others. The success rate was of 91% after the first surgery and 98% in large skull base defects and small/medium-sized respectively. After rescue surgery, the rate of closure achieved was 100%. The follow-up was 15.6 ± 12.4 months for large defects and 75.3 ± 51.3 months for small/medium-sized defects without recurrence. Endoscopic surgery for closure of any type of skull base defect is the gold standard approach. Defect size does not play a significant role in the success rate. Fascia lata and mucoperiosteum allow a reconstruction of small/medium-sized defects. For larger skull base defects, a combination of fat, fascia lata and nasoseptal pedicled flaps provide a successful reconstruction. Copyright © 2013 Elsevier España, S.L. All rights reserved.

16 CFR 1119.4 - Factors considered in determining civil penalties.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) The appropriateness of such penalty in relation to the size of the business of the person charged, including how to mitigate undue adverse economic impacts on small businesses; and (F) Such other factors as... relation to the size of the business of the person charged, including how to mitigate undue adverse...

13 CFR 121.603 - How does SBA determine whether a Participant is small for a particular 8(a) BD subcontract?

Code of Federal Regulations, 2010 CFR

2010-01-01

... determine whether a Participant is small for a particular 8(a) BD subcontract? (a) Self certification by... agency. The Participant also must submit a copy of its offer, including its self-certification as to size... nonmanufacturer rule to, 8(a) BD procurements. (b) Verification of size by SBA. Within 30 days of its receipt of a...

Designing and Maintaining the CATV and Small TV Studio.

ERIC Educational Resources Information Center

Knecht, Kenneth B.

Written especially for those who want expert, indepth guidance on setting up a small-to-medium size television studio, this handbook is a detailed guide on the installation and maintenance of production facilities for cable, closed-circuit, instructional, and small broadcast television studios. Detailed discussions are included of studio pulse…

A simulation of small to giant Antarctic iceberg evolution: Differential impact on climatology estimates

NASA Astrophysics Data System (ADS)

Rackow, Thomas; Wesche, Christine; Timmermann, Ralph; Hellmer, Hartmut H.; Juricke, Stephan; Jung, Thomas

2017-04-01

We present a simulation of Antarctic iceberg drift and melting that includes small, medium-sized, and giant tabular icebergs with a realistic size distribution. For the first time, an iceberg model is initialized with a set of nearly 7000 observed iceberg positions and sizes around Antarctica. The study highlights the necessity to account for larger and giant icebergs in order to obtain accurate melt climatologies. We simulate drift and lateral melt using iceberg-draft averaged ocean currents, temperature, and salinity. A new basal melting scheme, originally applied in ice shelf melting studies, uses in situ temperature, salinity, and relative velocities at an iceberg's bottom. Climatology estimates of Antarctic iceberg melting based on simulations of small (≤2.2 km), "small-to-medium-sized" (≤10 km), and small-to-giant icebergs (including icebergs >10 km) exhibit differential characteristics: successive inclusion of larger icebergs leads to a reduced seasonality of the iceberg meltwater flux and a shift of the mass input to the area north of 58°S, while less meltwater is released into the coastal areas. This suggests that estimates of meltwater input solely based on the simulation of small icebergs introduce a systematic meridional bias; they underestimate the northward mass transport and are, thus, closer to the rather crude treatment of iceberg melting as coastal runoff in models without an interactive iceberg model. Future ocean simulations will benefit from the improved meridional distribution of iceberg melt, especially in climate change scenarios where the impact of iceberg melt is likely to increase due to increased calving from the Antarctic ice sheet.

A basal dromaeosaurid and size evolution preceding avian flight.

PubMed

Turner, Alan H; Pol, Diego; Clarke, Julia A; Erickson, Gregory M; Norell, Mark A

2007-09-07

Fossil evidence for changes in dinosaurs near the lineage leading to birds and the origin of flight has been sparse. A dinosaur from Mongolia represents the basal divergence within Dromaeosauridae. The taxon's small body size and phylogenetic position imply that extreme miniaturization was ancestral for Paraves (the clade including Avialae, Troodontidae, and Dromaeosauridae), phylogenetically earlier than where flight evolution is strongly inferred. In contrast to the sustained small body sizes among avialans throughout the Cretaceous Period, the two dinosaurian lineages most closely related to birds, dromaeosaurids and troodontids, underwent four independent events of gigantism, and in some lineages size increased by nearly three orders of magnitude. Thus, change in theropod body size leading to flight's origin was not unidirectional.

Class Size, School Size and the Size of the School Network

ERIC Educational Resources Information Center

Coupé, Tom; Olefir, Anna; Alonso, Juan Diego

2016-01-01

In many transition countries, including Ukraine, decreases in population and fertility have led to substantial falls in the number of school-aged children. As a consequence, these countries now have school networks that consist of many small schools, leading many countries to consider reorganizing their networks by closing smaller schools and…

Differences in seed rain composition in small and large fragments in the northeast Brazilian Atlantic Forest.

PubMed

Knörr, U C; Gottsberger, G

2012-09-01

Tropical forests are seriously threatened by fragmentation and habitat loss. The impact of fragment size and forest configuration on the composition of seed rain is insufficiently studied. For the present study, seed rain composition of small and large forest fragments (8-388 ha) was assessed in order to identify variations in seed abundance, species richness, seed size and dispersal mode. Seed rain was documented during a 1-year period in three large and four small Atlantic Forest fragments that are isolated by a sugarcane matrix. Total seed rain included 20,518 seeds of 149 species of trees, shrubs, palms, lianas and herbs. Most species and seeds were animal-dispersed. A significant difference in the proportion of seeds and species within different categories of seed size was found between small and large fragments. Small fragments received significantly more very small-sized seeds (<0.3 cm) and less large-seeded species (>1.5 cm) that were generally very rare, with only one species in small and eight in large fragments. We found a negative correlation between the inflow of small-sized seeds and the percentage of forest cover. Species richness was lower in small than in large fragments, but the difference was not very pronounced. Given our results, we propose changing plant species pools through logging, tree mortality and a high inflow of pioneer species and lianas, especially in small forest fragments and areas with low forest cover. Connecting forest fragments through corridors and reforestation with local large-seeded tree species may facilitate the maintenance of species diversity. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

Marital quality and health: A meta-analytic review

PubMed Central

Robles, Theodore F.; Slatcher, Richard B.; Trombello, Joseph M.; McGinn, Meghan M.

2013-01-01

This meta-analysis reviewed 126 published empirical articles over the past 50 years describing associations between marital relationship quality and physical health in over 72,000 individuals. Health outcomes included clinical endpoints (objective assessments of function, disease severity, and mortality; subjective health assessments) and surrogate endpoints (biological markers that substitute for clinical endpoints, such as blood pressure). Biological mediators included cardiovascular reactivity and hypothalamic-pituitary-adrenal axis activity. Greater marital quality was related to better health, with mean effect sizes from r = .07 to .21, including lower risk of mortality, r = .11, and lower cardiovascular reactivity during marital conflict, r = −.13, but not daily cortisol slopes or cortisol reactivity during conflict. The small effect sizes were similar in magnitude to previously found associations between health behaviors (e.g., diet) and health outcomes. Effect sizes for a small subset of clinical outcomes were susceptible to publication bias. In some studies, effect sizes remained significant after accounting for confounds such as age and socioeconomic status. Studies with a higher proportion of women in the sample demonstrated larger effect sizes, but we found little evidence for gender differences in studies that explicitly tested gender moderation, with the exception of surrogate endpoint studies. Our conclusions are limited by small numbers of studies for specific health outcomes, unexplained heterogeneity, and designs that limit causal inferences. These findings highlight the need to explicitly test affective, health behavior, and biological mechanisms in future research, and focus on moderating factors that may alter the relationship between marital quality and health. PMID:23527470

On remote sensing of small aerosol particles with polarized light

NASA Astrophysics Data System (ADS)

Sun, W.

2012-12-01

The CALIPSO satellite mission consistently measures volume (including molecule and particulate) light depolarization ratio of ~2% for smoke, compared to ~1% for marine aerosols and ~15% for dust. The observed ~2% smoke depolarization ratio comes primarily from the nonspherical habits of particles in the smoke at certain particle sizes. The depolarization of linearly polarized light by small sphere aggregates and irregular Gaussian-shaped particles is studied, to reveal the physics between the depolarization of linearly polarized light and aerosol shape and size. It is found that randomly oriented nonspherical particles have some common depolarization properties as functions of scattering angle and size parameter. This may be very useful information for active remote sensing of small nonspherical aerosols using polarized light. We also show that the depolarization ratio from the CALIPSO measurements could be used to derive smoke aerosol particle size. The mean particle size of South-African smoke is estimated to be about half of the 532 nm wavelength of the CALIPSO lidar.

Isolation of nanoscale exosomes using viscoelastic effect

NASA Astrophysics Data System (ADS)

Hu, Guoqing; Liu, Chao

2017-11-01

Exosomes, molecular cargos secreted by almost all mammalian cells, are considered as promising biomarkers to identify many diseases including cancers. However, the small size of exosomes (30-200 nm) poses serious challenges on their isolation from the complex media containing a variety of extracellular vesicles (EVs) of different sizes, especially in small sample volumes. Here we develop a viscoelasticity-based microfluidic system to directly separate exosomes from cell culture media or serum in a continuous, size-dependent, and label-free manner. Using a small amount of biocompatible polymer as the additive into the media to control the viscoelastic forces exerted on EVs, we are able to achieve a high separation purity (>90%) and recovery (>80%) of exosomes. The size cutoff in viscoelasticity-based microfluidics can be easily controlled using different PEO concentrations. Based on this size-dependent viscoelastic separation strategy, we envision the handling of diverse nanoscale objects, such as gold nanoparticles, DNA origami structures, and quantum dots. This work was supported financially by National Natural Science Foundation of China (11572334, 91543125).

Commercial Internet Adoption in China: Comparing the Experience of Small, Medium and Large Businesses.

ERIC Educational Resources Information Center

Riquelme, Hernan

2002-01-01

Describes a study of small, medium, and large enterprises in Shanghai, China that investigated which size companies benefit the most from the Internet. Highlights include leveling the ground for small and medium enterprises (SMEs); increased sales and cost savings for large companies; and competitive advantages. (LRW)

Small Districts, Big Problems: Making School Everybody's House.

ERIC Educational Resources Information Center

Schmuck, Richard A.; Schmuck, Patricia A.

During a 6-month odyssey over America's back roads, 80 schools in 25 small school districts in 21 states were visited, in hopes of finding effective schools where smallness facilitated participation by all. District size ranged from 450 to 2,000 students. Data collection included observation of classes and meetings; group interviews of classes;…

VOLTTRON™: Tech-to-Market Best-Practices Guide for Small- and Medium-Sized Commercial Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cort, Katherine A.; Haack, Jereme N.; Katipamula, Srinivas

VOLTTRON™ is an open-source distributed control and sensing platform developed by Pacific Northwest National Laboratory for the U.S. Department of Energy. It was developed to be used by the Office of Energy Efficiency and Renewable Energy to support transactive controls research and deployment activities. VOLTTRON is designed to be an overarching integration platform that could be used to bring together vendors, users, and developers and enable rapid application development and testing. The platform is designed to support modern control strategies, including the use of agent- and transaction-based controls. It also is designed to support the management of a wide rangemore » of applications, including heating, ventilation, and air-conditioning systems; electric vehicles; and distributed-energy and whole-building loads. This report was completed as part of the Building Technologies Office’s Technology-to-Market Initiative for VOLTTRON’s Market Validation and Business Case Development efforts. The report provides technology-to-market guidance and best practices related to VOLTTRON platform deployments and commercialization activities for use by entities serving small- and medium-sized commercial buildings. The report characterizes the platform ecosystem within the small- and medium-sized commercial building market and articulates the value proposition of VOLTTRON for three core participants in this ecosystem: 1) platform owners/adopters, 2) app developers, and 3) end-users. The report also identifies key market drivers and opportunities for open platform deployments in the small- and medium-sized commercial building market. Possible pathways to the market are described—laboratory testing to market adoption to commercialization. We also identify and address various technical and market barriers that could hinder deployment of VOLTTRON. Finally, we provide “best practice” tech-to-market guidance for building energy-related deployment efforts serving small- and medium-sized commercial buildings.« less

Economic analysis of a small-sized combined heat and power plant using forest biomass in the Republic of Korea

Treesearch

Yeongwan Seo; Han-Sup Han; Edward M. (Ted) Bilek; Jungkee Choi; Dusong Cha; Jungsoo Lee

2017-01-01

Economic analysis was conducted on the feasibility of operating a small-sized (500kW/hour) gasification power plant producing heat and electricity in a rural town surrounded by forests in the Republic of Korea. Cost factors that were considered over the plant’s 20-year life included wood procurement, a wood grab loader, a chipper, a chip dryer, a gasifier, a generator...

Small Group Research

ERIC Educational Resources Information Center

McGrath, Joseph E.

1978-01-01

Summarizes research on small group processes by giving a comprehensive account of the types of variables primarily studied in the laboratory. These include group structure, group composition, group size, and group relations. Considers effects of power, leadership, conformity to social norms, and role relationships. (Author/AV)

Effects of growth rate, size, and light availability on tree survival across life stages: a demographic analysis accounting for missing values and small sample sizes.

PubMed

Moustakas, Aristides; Evans, Matthew R

2015-02-28

Plant survival is a key factor in forest dynamics and survival probabilities often vary across life stages. Studies specifically aimed at assessing tree survival are unusual and so data initially designed for other purposes often need to be used; such data are more likely to contain errors than data collected for this specific purpose. We investigate the survival rates of ten tree species in a dataset designed to monitor growth rates. As some individuals were not included in the census at some time points we use capture-mark-recapture methods both to allow us to account for missing individuals, and to estimate relocation probabilities. Growth rates, size, and light availability were included as covariates in the model predicting survival rates. The study demonstrates that tree mortality is best described as constant between years and size-dependent at early life stages and size independent at later life stages for most species of UK hardwood. We have demonstrated that even with a twenty-year dataset it is possible to discern variability both between individuals and between species. Our work illustrates the potential utility of the method applied here for calculating plant population dynamics parameters in time replicated datasets with small sample sizes and missing individuals without any loss of sample size, and including explanatory covariates.

X-Eye: a novel wearable vision system

NASA Astrophysics Data System (ADS)

Wang, Yuan-Kai; Fan, Ching-Tang; Chen, Shao-Ang; Chen, Hou-Ye

2011-03-01

This paper proposes a smart portable device, named the X-Eye, which provides a gesture interface with a small size but a large display for the application of photo capture and management. The wearable vision system is implemented with embedded systems and can achieve real-time performance. The hardware of the system includes an asymmetric dualcore processer with an ARM core and a DSP core. The display device is a pico projector which has a small volume size but can project large screen size. A triple buffering mechanism is designed for efficient memory management. Software functions are partitioned and pipelined for effective execution in parallel. The gesture recognition is achieved first by a color classification which is based on the expectation-maximization algorithm and Gaussian mixture model (GMM). To improve the performance of the GMM, we devise a LUT (Look Up Table) technique. Fingertips are extracted and geometrical features of fingertip's shape are matched to recognize user's gesture commands finally. In order to verify the accuracy of the gesture recognition module, experiments are conducted in eight scenes with 400 test videos including the challenge of colorful background, low illumination, and flickering. The processing speed of the whole system including the gesture recognition is with the frame rate of 22.9FPS. Experimental results give 99% recognition rate. The experimental results demonstrate that this small-size large-screen wearable system has effective gesture interface with real-time performance.

The effect of disorder of small spheres on the photonic properties of the inverse binary NaCl-like structure

NASA Astrophysics Data System (ADS)

Pattabhiraman, Harini; Dijkstra, Marjolein

2017-09-01

Inverse opal structures are experimentally realisable photonic band gap materials. They suffer from the drawback of possessing band gaps that are extremely susceptible to structural disorders. A binary colloidal NaCl lattice, which is also experimentally realisable, is a promising alternative to these opals. In this work, we systematically analyse the effect of structural disorder of the small spheres on the photonic properties of an inverse binary NaCl lattice with a size ratio of 0.30 between the small and large spheres. The types of structural disorders studied include the position of the small spheres in the octahedral void of the large spheres, polydispersity in size of the small spheres, and the fraction of small spheres in the crystal. We find a low susceptibility of the band gap of the inverse NaCl lattice to the disorder of the small spheres.

Trait-based prediction of extinction risk of small-bodied freshwater fishes.

PubMed

Kopf, R Keller; Shaw, Casey; Humphries, Paul

2017-06-01

Small body size is generally correlated with r-selected life-history traits, including early maturation, short-generation times, and rapid growth rates, that result in high population turnover and a reduced risk of extinction. Unlike other classes of vertebrates, however, small freshwater fishes appear to have an equal or greater risk of extinction than large fishes. We explored whether particular traits explain the International Union for Conservation of Nature (IUCN) Red List conservation status of small-bodied freshwater fishes from 4 temperate river basins: Murray-Darling, Australia; Danube, Europe; Mississippi-Missouri, North America; and the Rio Grande, North America. Twenty-three ecological and life-history traits were collated for all 171 freshwater fishes of ≤120 mm total length. We used generalized linear mixed-effects models to assess which combination of the 23 traits best explained whether a species was threatened or not threatened. We used the best models to predict the probability of 29 unclassified species being listed as threatened. With and without controlling for phylogeny at the family level, small body size-among small-bodied species-was the most influential trait correlated with threatened species listings. The k-folds cross-validation demonstrated that body size and a random effect structure that included family predicted the threat status with an accuracy of 78% (SE 0.5). We identified 10 species likely to be threatened that are not listed as such on the IUCN Red List. Small body size is not a trait that provides universal resistance to extinction, particularly for vertebrates inhabiting environments affected by extreme habitat loss and fragmentation. We hypothesize that this is because small-bodied species have smaller home ranges, lower dispersal capabilities, and heightened ecological specialization relative to larger vertebrates. Trait data and further model development are needed to predict the IUCN conservation status of the over 11,000 unclassified freshwater fishes, especially those under threat from proposed dam construction in the world's most biodiverse river basins. © 2016 Society for Conservation Biology.

Small benthic size classes along the N.W. European Continental Margin: spatial and temporal variability in activity and biomass

NASA Astrophysics Data System (ADS)

Pfannkuche, O.; Soltwedel, T.

1998-12-01

In the context of the European OMEX Programme this investigation focused on gradients in the biomass and activity of the small benthic size spectrum along a transect across the Goban Spur from the outer Celtic Sea into Porcupine Abyssal Plain. The effects of food pulses (seasonal, episodic) on this part of the benthic size spectrum were investigated. Sediments sampled during eight expeditions at different seasons covering a range from 200 m to 4800 m water depth were assayed with biochemical bulk measurements: determinations of chloroplastic pigment equivalents (CPE), the sum of chlorophyll a and its breakdown products, provide information concerning the input of phytodetrital matter to the seafloor; phospholipids were analyzed to estimate the total biomass of small benthic organisms (including bacteria, fungi, flagellata, protozoa and small metazoan meiofauna). A new term `small size class biomass' (SSCB) is introduced for the biomass of the smallest size classes of sediment-inhabiting organisms; the reduction of fluorescein-di-acetate (FDA) was determined to evaluate the potential activity of ester-cleaving bacterial exoenzymes in the sediment samples. At all stations benthic biomass was predominantly composed of the small size spectrum (90% on the shelf; 97-98% in the bathyal and abyssal parts of the transect). Small size class biomass (integrated over a 10 cm sediment column) ranged from 8 g C m -2 on the shelf to 2.1 g C m -2 on the adjacent Porcupine Abyssal Plain, exponentially decreasing with increasing water depth. However, a correlation between water depth and SSCB, macrofauna biomass as well as metazoan meiofauna biomass exhibited a significantly flatter slope for the small size classes in comparison to the larger organisms. CPE values indicated a pronounced seasonal cycle on the shelf and upper slope with twin peaks of phytodetrital deposition in mid spring and late summer. The deeper stations seem to receive a single annual flux maximum in late summer. SSCB and heterotrophic activity are significantly correlated to the amount of sediment-bound pigments. Seasonality in pigment concentrations is clearly followed by SSCB and activity. In contrast to macro- and megafauna which integrate over larger periods (months/years), the small benthic size classes, namely bacteria and foraminifera, proved to be the most reactive potential of the benthic communities to any perturbations on short time scales (days/weeks). The small size classes, therefore, occupy a key role in early diagenetic processes.

Regulatory scientific advice in drug development: does company size make a difference?

PubMed Central

Putzeist, Michelle; Gispen-De Wied, Christine C.; Hoes, Arno W.; Leufkens, Hubert G.

2010-01-01

Purpose To assess whether the content of Scientific Advice (SA) questions addressed to a national drug regulatory agency is associated with company size. This may help to increase understanding about the knowledge, strategic, and regulatory gaps companies face during drug development. Methodology A cross-sectional analysis was performed of SA provided by the Dutch Medicines Evaluation Board (MEB) in 2006–2008. Definition of company size was based on ranking by total revenues (Scrip’s Pharmaceutical Company League Tables 2008). The content of each SA question was scored according to predefined domains (quality, nonclinical, clinical, regulatory, and product information), their subdomains (e.g., efficacy), and a selection of additional content variables (e.g., endpoints, choice of active comparator). Results In total, 201 SA documents including 1,087 questions could be identified. Small, medium-sized, and large companies asked for SA 110 (54.7%), 40 (19.9%), and 51 (25.4%) times, respectively. Clinical questions were asked most often (65.9%), mainly including efficacy (33.2%) and safety questions (24.0%). The most frequent topics were overall efficacy and safety strategy. Small companies asked quality and nonclinical questions more often (P < 0.001) and clinical questions less frequently than large companies (P = 0.004). Small companies asked significantly more clinical questions about pharmacokinetics, including bioequivalence, than medium-sized and large companies (P < 0.001). Conclusion The array of topics addressed in SA provides an interesting outlook on what industry considers to be still unresolved in drug development and worthwhile to discuss with regulators. Company size is associated with the content of SA questions. MEB advice accommodates both innovative and noninnovative drug development. PMID:21049297

Regulatory scientific advice in drug development: does company size make a difference?

PubMed

Putzeist, Michelle; Mantel-Teeuwisse, Aukje K; Gispen-De Wied, Christine C; Hoes, Arno W; Leufkens, Hubert G

2011-02-01

To assess whether the content of Scientific Advice (SA) questions addressed to a national drug regulatory agency is associated with company size. This may help to increase understanding about the knowledge, strategic, and regulatory gaps companies face during drug development. A cross-sectional analysis was performed of SA provided by the Dutch Medicines Evaluation Board (MEB) in 2006-2008. Definition of company size was based on ranking by total revenues (Scrip's Pharmaceutical Company League Tables 2008). The content of each SA question was scored according to predefined domains (quality, nonclinical, clinical, regulatory, and product information), their subdomains (e.g., efficacy), and a selection of additional content variables (e.g., endpoints, choice of active comparator). In total, 201 SA documents including 1,087 questions could be identified. Small, medium-sized, and large companies asked for SA 110 (54.7%), 40 (19.9%), and 51 (25.4%) times, respectively. Clinical questions were asked most often (65.9%), mainly including efficacy (33.2%) and safety questions (24.0%). The most frequent topics were overall efficacy and safety strategy. Small companies asked quality and nonclinical questions more often (P < 0.001) and clinical questions less frequently than large companies (P = 0.004). Small companies asked significantly more clinical questions about pharmacokinetics, including bioequivalence, than medium-sized and large companies (P < 0.001). The array of topics addressed in SA provides an interesting outlook on what industry considers to be still unresolved in drug development and worthwhile to discuss with regulators. Company size is associated with the content of SA questions. MEB advice accommodates both innovative and noninnovative drug development.

Got power? A systematic review of sample size adequacy in health professions education research.

PubMed

Cook, David A; Hatala, Rose

2015-03-01

Many education research studies employ small samples, which in turn lowers statistical power. We re-analyzed the results of a meta-analysis of simulation-based education to determine study power across a range of effect sizes, and the smallest effect that could be plausibly excluded. We systematically searched multiple databases through May 2011, and included all studies evaluating simulation-based education for health professionals in comparison with no intervention or another simulation intervention. Reviewers working in duplicate abstracted information to calculate standardized mean differences (SMD's). We included 897 original research studies. Among the 627 no-intervention-comparison studies the median sample size was 25. Only two studies (0.3%) had ≥80% power to detect a small difference (SMD > 0.2 standard deviations) and 136 (22%) had power to detect a large difference (SMD > 0.8). 110 no-intervention-comparison studies failed to find a statistically significant difference, but none excluded a small difference and only 47 (43%) excluded a large difference. Among 297 studies comparing alternate simulation approaches the median sample size was 30. Only one study (0.3%) had ≥80% power to detect a small difference and 79 (27%) had power to detect a large difference. Of the 128 studies that did not detect a statistically significant effect, 4 (3%) excluded a small difference and 91 (71%) excluded a large difference. In conclusion, most education research studies are powered only to detect effects of large magnitude. For most studies that do not reach statistical significance, the possibility of large and important differences still exists.

The Potential of Distance Education and Training for Small and Medium-Sized Enterprises in the Mediterranean Countries of the European Community. A Report for the Commission of the European Communities--Task Force Human Resources, Education, Training, and Youth.

ERIC Educational Resources Information Center

Quintino, Luisa

An evaluation was made of the training needs of the small and medium-sized enterprises (SMEs) in Portugal, Spain, Greece, and Italy and the potential of open, distance, flexible, and multimedia learning to meet those needs. The methodology included contacts with training providers, governmental institutions, and SMEs and circulation of…

Growth performance and plasma metabolites in juvenile Siberian sturgeon Acipenser baerii (Brandt, 1869) subjected to various feeding strategies at different sizes.

PubMed

Jafari, Naghmeh; Falahatkar, Bahram; Sajjadi, Mir Masoud

2018-06-16

The effect of various feeding strategies was evaluated on growth performance and biochemical parameters in two sizes of Siberian sturgeon (465.75 ± 11.18 and 250.40 ± 12 g) during 45 days. Fish were distributed into six experimental treatments including large fish with satiation feeding (LA), small fish with satiation feeding (SA), large fish with 50% satiation feeding (LR), small fish with 50% satiation feeding (SR), large starved fish (LS), and small starved fish (SS). Differences in final weight between LA and LR treatments were not noticeable, whereas SA and SR treatments showed significant differences. Growth parameters were more affected in small fish. In condition factor and weight gain in starved treatments, a considerable reduction occurred by interaction between feeding strategies and fish size, so the lowest values were obtained in SS treatment. Glucose levels significantly decreased in small fish during the starvation. Interaction between feeding strategy and fish size indicated the highest and lowest albumin level in SA and SS treatment, respectively. Cholesterol, triglyceride, total protein, and globulin showed no significant differences. It can be deduced that small fish are more sensitive to starvation than the large fish. Since glucose and albumin showed significant decrease in starved small fish, these parameters can help to monitor nutritional status and feeding practices. It was indicated that in both sizes of Siberian sturgeon, feeding 50% satiation reduced the food cost without negative impact on physiological condition, and it can be considered as an appropriate strategy to face unfavorable circumstances.

Direct traumatic carotid cavernous fistula: angiographic classification and treatment strategies. Study of 172 cases.

PubMed

Chi, Cuong Tran; Nguyen, Dang; Duc, Vo Tan; Chau, Huynh Hong; Son, Vo Tan

2014-01-01

We report our experience in treatment of traumatic direct carotid cavernous fistula (CCF) via endovascular intervention. We hereof recommend an additional classification system for type A CCF and suggest respective treatment strategies. Only type A CCF patients (Barrow's classification) would be recruited for the study. Based on the angiographic characteristics of the CCF, we classified type A CCF into three subtypes including small size, medium size and large size fistula depending on whether there was presence of the anterior carotid artery (ACA) and/or middle carotid artery (MCA). Angiograms with opacification of both ACA and MCA were categorized as small size fistula. Angiograms with opacification of either ACA or MCA were categorized as medium size fistula and those without opacification of neither ACA nor MCA were classified as large size fiatula. After the confirm angiogram, endovascular embolization would be performed impromptu using detachable balloon, coils or both. All cases were followed up for complication and effect after the embolization. A total of 172 direct traumatic CCF patients were enrolled. The small size fistula was accountant for 12.8% (22 cases), medium size 35.5% (61 cases) and large size fistula accountant for 51.7% (89 cases). The successful rate of fistula occlusion under endovascular embolization was 94% with preservation of the carotid artery in 70%. For the treatment of each subtype, a total of 21/22 cases of the small size fistulas were successfully treated using coils alone. The other single case of small fistula was defaulted. Most of the medium and large size fistulas were cured using detachable balloons. When the fistula sealing could not be obtained using detachable balloon, coils were added to affirm the embolization of the cavernous sinus via venous access. There were about 2.9% of patient experienced direct carotid artery puncture and 0.6% puncture after carotid artery cut-down exposure. About 30% of cases experienced sacrifice of the parent vessels and it was associated with sizes of the fistula. Total severe complication was about 2.4% which included 1 death (0.6%) due to vagal shock; 1 transient hemiparesis post-sacrifice occlusion of the carotid artery but the patient had recovered after 3 months; 1 acute thrombus embolism and the patient was completely saved with recombinant tissue plaminogen activator (rTPA); 1 balloon dislodgement then got stuck at the anterior communicating artery but the patient was asymptomatic. Endovascular intervention as the treatment of direct traumatic CCF had high cure rate and low complication with its ability to preserve the carotid artery. It also can supply flexible accesses to the fistulous site with various alternative embolic materials. The new classification of type A CCF based on angiographic features was helpful for planning for the embolization. Coil should be considered as the first embolic material for small size fistula meanwhile detachable balloons was suggested as the first-choice embolic agent for the medium and large size fistula.

Inventory and Assessment of National Park Visitor Transportation Systems: Final Report

DOT National Transportation Integrated Search

1999-08-06

At least 47 National Park Service (NPS) units have public transportation systems. These systems, also known as Visitor Transportation Systems (VTSs), range in size from a small bus or tour boat to larger sized fleets, and include a variety of modes s...

Size matters: bigger is faster.

PubMed

Sereno, Sara C; O'Donnell, Patrick J; Sereno, Margaret E

2009-06-01

A largely unexplored aspect of lexical access in visual word recognition is "semantic size"--namely, the real-world size of an object to which a word refers. A total of 42 participants performed a lexical decision task on concrete nouns denoting either big or small objects (e.g., bookcase or teaspoon). Items were matched pairwise on relevant lexical dimensions. Participants' reaction times were reliably faster to semantically "big" versus "small" words. The results are discussed in terms of possible mechanisms, including more active representations for "big" words, due to the ecological importance attributed to large objects in the environment and the relative speed of neural responses to large objects.

Scattering from phase-separated vesicles. I. An analytical form factor for multiple static domains

DOE PAGES

Heberle, Frederick A.; Anghel, Vinicius N. P.; Katsaras, John

2015-08-18

This is the first in a series of studies considering elastic scattering from laterally heterogeneous lipid vesicles containing multiple domains. Unique among biophysical tools, small-angle neutron scattering can in principle give detailed information about the size, shape and spatial arrangement of domains. A general theory for scattering from laterally heterogeneous vesicles is presented, and the analytical form factor for static domains with arbitrary spatial configuration is derived, including a simplification for uniformly sized round domains. The validity of the model, including series truncation effects, is assessed by comparison with simulated data obtained from a Monte Carlo method. Several aspects ofmore » the analytical solution for scattering intensity are discussed in the context of small-angle neutron scattering data, including the effect of varying domain size and number, as well as solvent contrast. Finally, the analysis indicates that effects of domain formation are most pronounced when the vesicle's average scattering length density matches that of the surrounding solvent.« less

Cylindrical geometry hall thruster

DOEpatents

Raitses, Yevgeny; Fisch, Nathaniel J.

2002-01-01

An apparatus and method for thrusting plasma, utilizing a Hall thruster with a cylindrical geometry, wherein ions are accelerated in substantially the axial direction. The apparatus is suitable for operation at low power. It employs small size thruster components, including a ceramic channel, with the center pole piece of the conventional annular design thruster eliminated or greatly reduced. Efficient operation is accomplished through magnetic fields with a substantial radial component. The propellant gas is ionized at an optimal location in the thruster. A further improvement is accomplished by segmented electrodes, which produce localized voltage drops within the thruster at optimally prescribed locations. The apparatus differs from a conventional Hall thruster, which has an annular geometry, not well suited to scaling to small size, because the small size for an annular design has a great deal of surface area relative to the volume.

Do small animals have a biogeography?

PubMed

Valdecasas, A G; Camacho, A I; Peláez, M L

2006-01-01

It has been stated that small organisms do not have barriers for distribution and will not show biogeographic discreteness. General models for size-mediated biogeographies establish a transition region between ubiquitous dispersal and restricted biogeography at about 1-10 mm. We tested patterns of distribution versus size with water mites, a group of freshwater organisms with sizes between 300 microm and 10 mm. We compiled a list of all known water mite species for Sierra del Guadarrama (a mountain range in the centre of the Iberian Peninsula) from different authors and our own studies in the area. Recorded habitats include lotic, lentic and interstitial environments. Species body size and world distribution were drawn from our work and published specialized taxonomic literature. The null hypothesis was that distribution is size-independent. The relationship between distribution and size was approached via analysis of variance and between size and habitat via logistic regression. Contrary to expectations, there is no special relationship between water mite size and area size distribution. On the other hand, water mite size is differentially distributed among habitats, although this ecological sorting is very weak. Larger water mites are more common in lentic habitats and smaller water mites in lotic habitats. Size-dependent distribution in which small organisms tend to be cosmopolitan breaks down when the particular biology comes into play. Water mites do not fit a previously proposed size-dependent biogeographical distribution, and are in accordance with similar data published on Tardigrada, Rotifera, Gastrotricha and the like.

Exploring Student-Faculty Interactions in Out-of-Classroom Settings: Student Perspectives at Small Liberal Arts Colleges

ERIC Educational Resources Information Center

Gauthier, Amy P.

2012-01-01

Students choose to attend liberal arts institutions for a number of different reasons, including small class size, breadth of academic material, and emphasis on life-long learning (Astin, 1999; Pascarella, Cruce, Wolniak, & Blaich, 2004). Those attending small liberal arts colleges have come to expect that they will have a higher level of…

Evaluating small-body landing hazards due to blocks

NASA Astrophysics Data System (ADS)

Ernst, C.; Rodgers, D.; Barnouin, O.; Murchie, S.; Chabot, N.

2014-07-01

Introduction: Landed missions represent a vital stage of spacecraft exploration of planetary bodies. Landed science allows for a wide variety of measurements essential to unraveling the origin and evolution of a body that are not possible remotely, including but not limited to compositional measurements, microscopic grain characterization, and the physical properties of the regolith. To date, two spacecraft have performed soft landings on the surface of a small body. In 2001, the Near Earth Asteroid Rendezvous (NEAR) mission performed a controlled descent and landing on (433) Eros following the completion of its mission [1]; in 2005, the Hayabusa spacecraft performed two touch-and-go maneuvers at (25143) Itokawa [2]. Both landings were preceded by rendezvous spacecraft reconnaissance, which enabled selection of a safe landing site. Three current missions have plans to land on small bodies (Rosetta, Hayabusa 2, and OSIRIS-REx); several other mission concepts also include small-body landings. Small-body landers need to land at sites having slopes and block abundances within spacecraft design limits. Due to the small scale of the potential hazards, it can be difficult or impossible to fully characterize a landing surface before the arrival of the spacecraft at the body. Although a rendezvous mission phase can provide global reconnaissance from which a landing site can be chosen, reasonable a priori assurance that a safe landing site exists is needed to validate the design approach for the spacecraft. Method: Many robotic spacecraft have landed safely on the Moon and Mars. Images of these landing sites, as well as more recent, extremely high-resolution orbital datasets, have enabled the comparison of orbital block observations to the smaller blocks that pose hazards to landers. Analyses of the Surveyor [3], Viking 1 and 2, Mars Pathfinder, Phoenix, Spirit, Opportunity, and Curiosity landing sites [4--8] have indicated that for a reasonable difference in size (a factor of several to ten), the size-frequency distribution of blocks can be modeled, allowing extrapolation from large block distributions to estimate small block densities. From that estimate, the probability of a lander encountering hazardous blocks can be calculated for a given lander design. Such calculations are used routinely to vet candidate sites for Mars landers [5--8]. Application to Small Bodies: To determine whether a similar approach will work for small bodies, we must determine if the large and small block populations can be linked. To do so, we analyze the comprehensive block datasets for the intermediate-sized Eros [9,10] and the small Itokawa [11,12]. Global and local block size-frequency distributions for Eros and Itokawa have power-law slopes on the order of -3 and match reasonably well between larger block sizes (from lower-resolution images) and smaller block sizes (from higher-resolution images). Although absolute block densities differ regionally on each asteroid, the slopes match reasonably well between Itokawa and Eros, with the geologic implications of this result discussed in [10]. For Eros and Itokawa, the approach of extending the size-frequency distribution from large, tens-of-meter-sized blocks down to small, tens-of-centimeter-sized blocks using a power-law fit to the large population yields reasonable estimates of small block populations. It is important to note that geologic context matters for the absolute block density --- if the global counts include multiple geologic settings, they will not directly extend to local areas containing only one setting [10]. A small number of high-resolution images of Phobos are sufficient for measuring blocks. These images are concentrated in the area outside of Stickney crater, which is thought to be the source of most of the observed blocks [13]. Block counts by Thomas et al. [13] suggest a power-law slope similar to those of Eros [9] and Itokawa global counts, with the absolute density of blocks similar to that of global Eros. Because blocks tend to be more numerous proximal to large, young craters (e.g., Stickney on Phobos, Shoemaker on Eros), the block density across most of Phobos is likely to be lower than that observed in the available high-resolution images. We suggest that a power-law extrapolation of Eros or Phobos large-block distributions provides upper limits for assessing the block landing hazards faced by a Phobos lander.

Dependence of the forward light scattering on the refractive index of particles

NASA Astrophysics Data System (ADS)

Guo, Lufang; Shen, Jianqi

2018-05-01

In particle sizing technique based on forward light scattering, the scattered light signal (SLS) is closely related to the relative refractive index (RRI) of the particles to the surrounding, especially when the particles are transparent (or weakly absorbent) and the particles are small in size. The interference between the diffraction (Diff) and the multiple internal reflections (MIR) of scattered light can lead to the oscillation of the SLS on RRI and the abnormal intervals, especially for narrowly-distributed small particle systems. This makes the inverse problem more difficult. In order to improve the inverse results, Tikhonov regularization algorithm with B-spline functions is proposed, in which the matrix element is calculated for a range of particle sizes instead using the mean particle diameter of size fractions. In this way, the influence of abnormal intervals on the inverse results can be eliminated. In addition, for measurements on narrowly distributed small particles, it is suggested to detect the SLS in a wider scattering angle to include more information.

A comparison of confidence/credible interval methods for the area under the ROC curve for continuous diagnostic tests with small sample size.

PubMed

Feng, Dai; Cortese, Giuliana; Baumgartner, Richard

2017-12-01

The receiver operating characteristic (ROC) curve is frequently used as a measure of accuracy of continuous markers in diagnostic tests. The area under the ROC curve (AUC) is arguably the most widely used summary index for the ROC curve. Although the small sample size scenario is common in medical tests, a comprehensive study of small sample size properties of various methods for the construction of the confidence/credible interval (CI) for the AUC has been by and large missing in the literature. In this paper, we describe and compare 29 non-parametric and parametric methods for the construction of the CI for the AUC when the number of available observations is small. The methods considered include not only those that have been widely adopted, but also those that have been less frequently mentioned or, to our knowledge, never applied to the AUC context. To compare different methods, we carried out a simulation study with data generated from binormal models with equal and unequal variances and from exponential models with various parameters and with equal and unequal small sample sizes. We found that the larger the true AUC value and the smaller the sample size, the larger the discrepancy among the results of different approaches. When the model is correctly specified, the parametric approaches tend to outperform the non-parametric ones. Moreover, in the non-parametric domain, we found that a method based on the Mann-Whitney statistic is in general superior to the others. We further elucidate potential issues and provide possible solutions to along with general guidance on the CI construction for the AUC when the sample size is small. Finally, we illustrate the utility of different methods through real life examples.

Deliquescence and efflorescence of small particles.

PubMed

McGraw, Robert; Lewis, Ernie R

2009-11-21

We examine size-dependent deliquescence/efflorescence phase transformation for particles down to several nanometers in size. Thermodynamic properties of inorganic salt particles, coated with aqueous solution layers of varying thickness and surrounded by vapor, are analyzed. A thin layer criterion (TLC) is introduced to define a limiting deliquescence relative humidity (RH(D)) for small particles. This requires: (1) equality of chemical potentials between salt in an undissolved core, and thin adsorbed solution layer, and (2) equality of chemical potentials between water in the thin layer and vapor phase. The usual bulk deliquescence conditions are recovered in the limit of large dry particle size. Nanosize particles are found to deliquesce at relative humidity just below the RH(D) on crossing a nucleation barrier, located at a critical solution layer thickness. This barrier vanishes precisely at the RH(D) defined by the TLC. Concepts and methods from nucleation theory including the kinetic potential, self-consistent nucleation theory, nucleation theorems, and the Gibbs dividing surface provide theoretical foundation and point to unifying features of small particle deliquescence/efflorescence processes. These include common thermodynamic area constructions, useful for interpretation of small particle water uptake measurements, and a common free-energy surface, with constant RH cross sections describing deliquescence and efflorescence related through the nucleation theorem.

Shared and Distinct Rupture Discriminants of Small and Large Intracranial Aneurysms.

PubMed

Varble, Nicole; Tutino, Vincent M; Yu, Jihnhee; Sonig, Ashish; Siddiqui, Adnan H; Davies, Jason M; Meng, Hui

2018-04-01

Many ruptured intracranial aneurysms (IAs) are small. Clinical presentations suggest that small and large IAs could have different phenotypes. It is unknown if small and large IAs have different characteristics that discriminate rupture. We analyzed morphological, hemodynamic, and clinical parameters of 413 retrospectively collected IAs (training cohort; 102 ruptured IAs). Hierarchal cluster analysis was performed to determine a size cutoff to dichotomize the IA population into small and large IAs. We applied multivariate logistic regression to build rupture discrimination models for small IAs, large IAs, and an aggregation of all IAs. We validated the ability of these 3 models to predict rupture status in a second, independently collected cohort of 129 IAs (testing cohort; 14 ruptured IAs). Hierarchal cluster analysis in the training cohort confirmed that small and large IAs are best separated at 5 mm based on morphological and hemodynamic features (area under the curve=0.81). For small IAs (<5 mm), the resulting rupture discrimination model included undulation index, oscillatory shear index, previous subarachnoid hemorrhage, and absence of multiple IAs (area under the curve=0.84; 95% confidence interval, 0.78-0.88), whereas for large IAs (≥5 mm), the model included undulation index, low wall shear stress, previous subarachnoid hemorrhage, and IA location (area under the curve=0.87; 95% confidence interval, 0.82-0.93). The model for the aggregated training cohort retained all the parameters in the size-dichotomized models. Results in the testing cohort showed that the size-dichotomized rupture discrimination model had higher sensitivity (64% versus 29%) and accuracy (77% versus 74%), marginally higher area under the curve (0.75; 95% confidence interval, 0.61-0.88 versus 0.67; 95% confidence interval, 0.52-0.82), and similar specificity (78% versus 80%) compared with the aggregate-based model. Small (<5 mm) and large (≥5 mm) IAs have different hemodynamic and clinical, but not morphological, rupture discriminants. Size-dichotomized rupture discrimination models performed better than the aggregate model. © 2018 American Heart Association, Inc.

An Empirical Study about the Effect of Cultural Problematic on Organizational Learning in Alliances.

ERIC Educational Resources Information Center

Rodriguez, Sonia Dasi; Perez, Juan Francisco Martinez; del Val, Manuela Pardo

2003-01-01

A study of 19 small and medium-sized Spanish companies that established international cooperation agreements during 1997-1998 demonstrated that organizational cultures, company size, and national cultures significantly influence the learning that occurs. Negative influences include different work attitudes, languages, and communication systems. A…

Electrophysiological property and chemical sensitivity of primary afferent neurons that innervate rat whisker hair follicles.

PubMed

Ikeda, Ryo; Gu, Jianguo

2016-01-01

Whisker hair follicles are sensory organs that sense touch and perform tactile discrimination in animals, and they are sites where sensory impulses are initiated when whisker hairs touch an object. The sensory signals are then conveyed by whisker afferent fibers to the brain for sensory perception. Electrophysiological property and chemical sensitivity of whisker afferent fibers, important factors affecting whisker sensory processing, are largely not known. In the present study, we performed patch-clamp recordings from pre-identified whisker afferent neurons in whole-mount trigeminal ganglion preparations and characterized their electrophysiological property and sensitivity to ATP, serotonin and glutamate. Of 97 whisker afferent neurons examined, 67% of them are found to be large-sized (diameter ≥45 µm) cells and 33% of them are medium- to small-sized (diameter <45 µm) cells. Almost every large-sized whisker afferent neuron fires a single action potential but many (40%) small/medium-sized whisker afferent neurons fire multiple action potentials in response to prolonged stepwise depolarization. Other electrophysiological properties including resting membrane potential, action potential threshold, and membrane input resistance are also significantly different between large-sized and small/medium-sized whisker afferent neurons. Most large-sized and many small/medium-sized whisker afferent neurons are sensitive to ATP and/or serotonin, and ATP and/or serotonin could evoke strong inward currents in these cells. In contrast, few whisker afferent neurons are sensitive to glutamate. Our results raise a possibility that ATP and/or serotonin may be chemical messengers involving sensory signaling for different types of rat whisker afferent fibers.

The Role of Breast Size and Areolar Pigmentation in Perceptions of Women's Sexual Attractiveness, Reproductive Health, Sexual Maturity, Maternal Nurturing Abilities, and Age.

PubMed

Dixson, Barnaby J; Duncan, Melanie; Dixson, Alan F

2015-08-01

Women's breast morphology is thought to have evolved via sexual selection as a signal of maturity, health, and fecundity. While research demonstrates that breast morphology is important in men's judgments of women's attractiveness, it remains to be determined how perceptions might differ when considering a larger suite of mate relevant attributes. Here, we tested how variation in breast size and areolar pigmentation affected perceptions of women's sexual attractiveness, reproductive health, sexual maturity, maternal nurturing abilities, and age. Participants (100 men; 100 women) rated images of female torsos modeled to vary in breast size (very small, small, medium, and large) and areolar pigmentation (light, medium, and dark) for each of the five attributes listed above. Sexual attractiveness ratings increased linearly with breast size, but large breasts were not judged to be significantly more attractive than medium-sized breasts. Small and medium-sized breasts were rated as most attractive if they included light or medium colored areolae, whereas large breasts were more attractive if they had medium or dark areolae. Ratings for perceived age, sexual maturity, and nurturing ability also increased with breast size. Darkening the areolae reduced ratings of the reproductive health of medium and small breasts, whereas it increased ratings for large breasts. There were no significant sex differences in ratings of any of the perceptual measures. These results demonstrate that breast size and areolar pigmentation interact to determine ratings for a suite of sociosexual attributes, each of which may be relevant to mate choice in men and intra-sexual competition in women.

2012 Market Report on Wind Technologies in Distributed Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orrell, Alice C.

2013-08-01

An annual report on U.S. wind power in distributed applications – expanded to include small, mid-size, and utility-scale installations – including key statistics, economic data, installation, capacity, and generation statistics, and more.

101 Ways to Save Money in Small Schools.

ERIC Educational Resources Information Center

Bratlie, Ron

This paper is a checklist on ways to save money targeted to administrators of small rural schools but appropriate to schools of any size. Tips concerning staff include salary issues, early retirement, time management techniques, involving staff in budget and facilities planning, and utilizing limited-experience teachers, teacher-administrators,…

Topology and cellular localization of the small hydrophobic protein of avian metapneumovirus

USDA-ARS?s Scientific Manuscript database

The small hydrophobic protein (SH) is a type II integral membrane protein that is packaged into virions and is only present in certain paramyxoviruses including metapneumovirus. In addition to a highly divergent primary sequence, SH proteins vary significantly in size among the different viruses. Hu...

Face-to-Face or Distance Training? Two Different Approaches To Motivate SMEs To Learn--An Update.

ERIC Educational Resources Information Center

Allan, John; O'Dwyer, Michele; Ryan, Eamon; Lawless, Naomi

2001-01-01

Two projects attempted to assess and meet small and medium-sized enterprises' training needs. Britain's Learning support for Small Businesses delivery methods included paper, CD-ROM, and the Internet. The University of Limerick, Ireland, offered face-to-face learning for microenterprises. (SK)

SMEs and Barriers to Skill Development: A Scottish Perspective.

ERIC Educational Resources Information Center

Lange, Thomas; Ottens, Melanie; Taylor, Andrea

2000-01-01

Analysis of Scottish small and medium-sized enterprises reveals that small business culture is a significant barrier to skill development. Other barriers include awareness, finance, and access to training. A welter of recent policy initiatives has added to a state of confusion about the role of training. (SK)

[Study on anemia and vitamin A and vitamin D nutritional status of Chinese urban pregnant women in 2010-2012].

PubMed

Hu, Y C; Chen, J; Li, M; Wang, R; Li, W D; Yang, Y H; Yang, C; Yun, C F; Yang, L C; Yang, X G

2017-02-06

Objective: To evaluate the prevalence of anemia and the nutritional status of vitamins A and D by analyzing hemoglobin, serum retinol, and serum 25-hydroxyvitamin D levels in Chinese urban pregnant women during 2010-2012. Methods: Data were obtained from the China Nutrition and Health Survey in 2010-2012. Using multi-stage stratified sampling and population proportional stratified random sampling, 2 250 pregnant women from 34 metropolis and 41 middle-sized and small cities were included in this study. Information was collected using a questionnaire survey. The blood hemoglobin concentration was determined using the cyanmethemoglobin method, and anemia was determined using the World Health Organization guidelines combined with the elevation correction standard. The serum retinol level was determined using high-performance liquid chromatography, and vitamin A deficiency (VAD) was judged by the related standard recommended by the World Health Organization. The vitamin D level was determined using enzyme-linked immunosorbent assay and vitamin D deficiency was judged by the recommendation standards from the Institute of Medicine of The National Academies. The hemoglobin, serum retinol, and serum 25-hydroxyvitamin D levels were compared, along with differences in the prevalence of anemia, VAD, and the vitamin D deficiency rate (including deficiency and serious deficiency). Results: A total of 1 738 cases of hemoglobin level, 594 cases of serum retinol level, and 1 027 cases of serum 25-hydroxyvitamin D were available for analysis in this study. The overall blood hemoglobin level ( P (50) ( P (25)- P (75))) was 122.70 (114.00-131.10) g/L; 123.70 (115.21-132.00) g/L for metropolis and 122.01 (113.30-130.40) g/L for middle-sized and small cities. The blood hemoglobin level of metropolis residents was significantly higher than that of middle-sized and small city residents ( P= 0.027). The overall prevalence of anemia was 17.0% (295/1 738). The overall serum retinol level ( P (50) ( P (25)- P (75))) was 1.61 (1.20-2.06) μmol/L; 1.50 (1.04-2.06) μmol/L for metropolis and 1.63 (1.31-2.05) μmol/L for middle-sized and small cities. The serum retinol level of metropolis residents was significantly higher than that of middle-sized and small city residents ( P= 0.033). The overall prevalence of VAD was 7.4% (47/639); 11.5% (33/286) for metropolis and 4.0% (14/353) for middle-sized and small cities. A significant difference was observed in the prevalence of VAD between metropolis and middle-sized and small city residents ( P< 0.001). The overall serum 25-hydroxyvitamin D level ( P (50) ( P (25)- P (75))) was 15.41 (11.79-20.23) ng/ml; 14.71 (11.15-19.07) ng/ml for metropolis and 16.02 (12.65-21.36) ng/ml for middle-sized and small cities. A significant difference was observed in the vitamin D level between metropolis and middle-sized and small city residents ( P< 0.001). The overall prevalence of vitamin D deficiency was 74.3% (763/1 027); A significant difference was observed in the prevalence of serious vitamin D deficiency between metropolis (30.64%(144/470)) and middle-sized and small city residents (26%(267/1 027))( P= 0.002). There were no significant differences between blood hemoglobin level and the prevalence of anemia, VAD, and vitamin D deficiency. Conclusion: The prevalence of anemia in Chinese urban pregnant women improved from 2002 to 2012. The prevalence of vitamin D deficiency in pregnant women was generally more serious, while a certain percentage of women had VAD. The prevalence of VAD and serious vitamin D deficiency among pregnant women from metropolis was significantly higher than that of pregnant women from medium and small-sized cities.

A simulation of small to giant Antarctic iceberg evolution: differential impact on climatology estimates

NASA Astrophysics Data System (ADS)

Rackow, Thomas; Wesche, Christine; Timmermann, Ralph; Hellmer, Hartmut H.; Juricke, Stephan; Jung, Thomas

2017-04-01

We present a simulation of Antarctic iceberg drift and melting that includes small (<2.2 km), medium-sized, and giant tabular icebergs with lengths of more than 10km. The model is initialized with a realistic size distribution obtained from satellite observations. Our study highlights the necessity to account for larger and giant icebergs in order to obtain accurate melt climatologies. Taking iceberg modeling a step further, we simulate drift and melting using iceberg-draft averaged ocean currents, temperature, and salinity. A new basal melting scheme, originally applied in ice shelf melting studies, uses in situ temperature, salinity, and relative velocities at an iceberg's keel. The climatology estimates of Antarctic iceberg melting based on simulations of small, 'small-to-medium'-sized, and small-to-giant icebergs (including icebergs > 10km) exhibit differential characteristics: successive inclusion of larger icebergs leads to a reduced seasonality of the iceberg meltwater flux and a shift of the mass input to the area north of 58°S, while less meltwater is released into the coastal areas. This suggests that estimates of meltwater input solely based on the simulation of small icebergs introduce a systematic meridional bias; they underestimate the northward mass transport and are, thus, closer to the rather crude treatment of iceberg melting as coastal runoff in models without an interactive iceberg model. Future ocean simulations will benefit from the improved meridional distribution of iceberg melt, especially in climate change scenarios where the impact of iceberg melt is likely to increase due to increased calving from the Antarctic ice sheet.

Short-Term File Reference Patterns in a UNIX Environment,

DTIC Science & Technology

1986-03-01

accounts mentioned ahose. This includes major administrative and status files (for example, /etc/ passwd ), system libraries, system include files and so on...34 files are those appearing in / and /etc. Examples are /vmunix (the bootable kernel image) and /etc/ passwd (passwords and other information on accounts...as /etc/ passwd ). The small size of opened files (55% are under 1024 bytes, a common block transfer size, and 75% are under 4096 bytes) suggests that

CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer.

PubMed

Rizzo, Stefania; Petrella, Francesco; Buscarino, Valentina; De Maria, Federica; Raimondi, Sara; Barberis, Massimo; Fumagalli, Caterina; Spitaleri, Gianluca; Rampinelli, Cristiano; De Marinis, Filippo; Spaggiari, Lorenzo; Bellomi, Massimo

2016-01-01

To assess the association between CT features and EGFR, ALK, KRAS mutations in non-small cell lung cancer. Patients undergoing chest CT and testing for the above gene mutations were included. Qualitative evaluation of CTs included: lobe; lesion diameter; shape; margins; ground-glass opacity; density; cavitation; air bronchogram; pleural thickening; intratumoral necrosis; nodules in tumour lobe; nodules in non-tumour lobes; pleural retraction; location; calcifications; emphysema; fibrosis; pleural contact; pleural effusion. Statistical analysis was performed to assess association of features with each gene mutation. ROC curves for gene mutations were drawn; the corresponding area under the curve was calculated. P-values <0.05 were considered significant. Of 285 patients, 60/280 (21.43 %) were positive for EGFR mutation; 31/270 (11.48 %) for ALK rearrangement; 64/240 (26.67 %) for KRAS mutation. EGFR mutation was associated with air bronchogram, pleural retraction, females, non-smokers, small lesion size, and absence of fibrosis. ALK rearrangements were associated with age and pleural effusion. KRAS mutation was associated with round shape, nodules in non-tumour lobes, and smoking. This study disclosed associations between CT features and alterations of EGFR (air bronchogram, pleural retraction, small lesion size, absence of fibrosis), ALK (pleural effusion) and KRAS (round lesion shape, nodules in non-tumour lobes). Air bronchogram, pleural retraction, small size relate to EGFR mutation in NSCLC. Pleural effusion and younger age relate to ALK mutation. Round lesion shape, nodules in non-tumour lobes relate to KRAS mutation.

A Comparative Study: Completion of Fine Motor Office Related Tasks by High School Students with Autism Using Video Models on Large and Small Screen Sizes

ERIC Educational Resources Information Center

Mechling, Linda C.; Ayres, Kevin M.

2012-01-01

The purpose of this investigation was to compare fine motor task completion when using video models presented on a smaller screen size (Personal Digital Assistant) compared to a larger laptop screen size. The investigation included four high school students with autism spectrum disorders and mild to moderate intellectual disabilities and used an…

13 CFR 121.108 - What are the requirements for representing small business size status, and what are the penalties...

Code of Federal Regulations, 2014 CFR

2014-01-01

... determination may include the firm's internal management procedures governing size representation or certification, the clarity or ambiguity of the representation or certification requirement, and the efforts made to correct an incorrect or invalid representation or certification in a timely manner. An individual...

Neural Network Control of a Parallel Hybrid-Electric Propulsion System for a Small Unmanned Aerial Vehicle

DTIC Science & Technology

2004-01-01

ion battery pack sized for endurance speed. The flexible optimization routine allows relative importance to be assigned between the use of gasoline...simulation results are provided. The two-point conceptual design includes an internal combustion engine sized for cruise and an electric motor and lithium

14 CFR Appendix F to Part 23 - Test Procedure

Code of Federal Regulations, 2011 CFR

2011-01-01

... materials used in electrical wire and cable insulation and in small parts, materials must be tested either... wire and cable insulation, the wire and cable specimens must be the same size as used in the airplane... specification (make and size) must be tested. The specimen of wire or cable (including insulation) must be...

Genome size variation among sex types in dioecious and triecious Caricaceae species

USDA-ARS?s Scientific Manuscript database

Caricaceae is a small family consisting of 35 species of varying sexual systems and includes economically important fruit crop, Carica papaya, and other species of “highland papayas”. Flow cytometry was used to obtain genome sizes for 11 species in three genera of Caricaceae to determine if genome s...

Enhancement and degradation of the R2* relaxation rate resulting from the encapsulation of magnetic particles with hydrophilic coatings.

PubMed

de Haan, Hendrick W; Paquet, Chantal

2011-12-01

The effects of including a hydrophilic coating around the particles are studied across a wide range of particle sizes by performing Monte Carlo simulations of protons diffusing through a system of magnetic particles. A physically realistic methodology of implementing the coating by cross boundary jump scaling and transition probabilities at the coating surface is developed. Using this formulation, the coating has three distinct impacts on the relaxation rate: an enhancement at small particle sizes, a degradation at intermediate particle sizes, and no effect at large particles sizes. These varied effects are reconciled with the underlying dephasing mechanisms by using the concept of a full dephasing zone to present a physical picture of the dephasing process with and without the coating for all sizes. The enhancement at small particle sizes is studied systemically to demonstrate the existence of an optimal ratio of diffusion coefficients inside/outside the coating to achieve maximal increase in the relaxation rate. Copyright © 2011 Wiley Periodicals, Inc.

Development of the Breakaway Integrated Chin-Nape Strap

DTIC Science & Technology

2005-10-01

Concurrent with the increased use of HMS, the anthropometry of the aircrew has been expanding to include smaller and larger sized individuals as well as a...sized helmet (L/ XL ), and one for individuals less than 73 kg, who wear a small or medium sized helmet (S/M). For each size a lower limit was given such...of approximately 600 Lbs +- 65 Lbs (Pellettiere 2002). To develop the L/ XL corridor, the average failure load for the SCNS was increased by

Cognitive and Occupational Function in Survivors of Adolescent Cancer.

PubMed

Nugent, Bethany D; Bender, Catherine M; Sereika, Susan M; Tersak, Jean M; Rosenzweig, Margaret

2018-02-01

Adolescents with cancer have unique developmental considerations. These include brain development, particularly in the frontal lobe, and a focus on completing education and entering the workforce. Cancer and treatment at this stage may prove to uniquely affect survivors' experience of cognitive and occupational function. An exploratory, cross-sectional, descriptive comparative study was employed to describe cognitive and occupational function in adult survivors of adolescent cancer (diagnosed between the ages of 15 and 21 years) and explore differences in age- and gender-matched controls. In total, 23 survivors and 14 controls participated in the study. While significant differences were not found between the groups on measures of cognitive and occupational function, several small and medium effect sizes were found suggesting that survivors may have greater difficulty than controls. Two small effect sizes were found in measures of neuropsychological performance (the Digit Vigilance test [d = 0.396] and Stroop test [d = 0.226]). Small and medium effect sizes ranging from 0.269 to 0.605 were found for aspects of perceived and total cognitive function. A small effect size was also found in work output (d = 0.367). While we did not find significant differences in cognitive or occupational function between survivors and controls, the effect sizes observed point to the need for future research. Future work using a larger sample size and longitudinal design are needed to further explore cognitive and occupational function in this vulnerable and understudied population and assist in the understanding of patterns of change over time.

Intra- and Trans-Generational Costs of Reduced Female Body Size Caused by Food Limitation Early in Life in Mites

PubMed Central

Walzer, Andreas; Schausberger, Peter

2013-01-01

Background Food limitation early in life may be compensated for by developmental plasticity resulting in accelerated development enhancing survival at the expense of small adult body size. However and especially for females in non-matching maternal and offspring environments, being smaller than the standard may incur considerable intra- and trans-generational costs. Methodology/Principal Findings Here, we evaluated the costs of small female body size induced by food limitation early in life in the sexually size-dimorphic predatory mite Phytoseiulus persimilis. Females are larger than males. These predators are adapted to exploit ephemeral spider mite prey patches. The intra- and trans-generational effects of small maternal body size manifested in lower maternal survival probabilities, decreased attractiveness for males, and a reduced number and size of eggs compared to standard-sized females. The trans-generational effects of small maternal body size were sex-specific with small mothers producing small daughters but standard-sized sons. Conclusions/Significance Small female body size apparently intensified the well-known costs of sexual activity because mortality of small but not standard-sized females mainly occurred shortly after mating. The disadvantages of small females in mating and egg production may be generally explained by size-associated morphological and physiological constraints. Additionally, size-assortative mate preferences of standard-sized mates may have rendered small females disproportionally unattractive mating partners. We argue that the sex-specific trans-generational effects were due to sexual size dimorphism – females are the larger sex and thus more strongly affected by maternal stress than the smaller males – and to sexually selected lower plasticity of male body size. PMID:24265745

The effect of radiation pressure on spatial distribution of dust inside H II regions

NASA Astrophysics Data System (ADS)

Ishiki, Shohei; Okamoto, Takashi; Inoue, Akio K.

2018-02-01

We investigate the impact of radiation pressure on spatial dust distribution inside H II regions using one-dimensional radiation hydrodynamic simulations, which include absorption and re-emission of photons by dust. In order to investigate grain-size effects as well, we introduce two additional fluid components describing large and small dust grains in the simulations. Relative velocity between dust and gas strongly depends on the drag force. We include collisional drag force and coulomb drag force. We find that, in a compact H II region, a dust cavity region is formed by radiation pressure. Resulting dust cavity sizes (˜0.2 pc) agree with observational estimates reasonably well. Since dust inside an H II region is strongly charged, relative velocity between dust and gas is mainly determined by the coulomb drag force. Strength of the coulomb drag force is about 2 order of magnitude larger than that of the collisional drag force. In addition, in a cloud of mass 105 M⊙, we find that the radiation pressure changes the grain-size distribution inside H II regions. Since large (0.1 μm) dust grains are accelerated more efficiently than small (0.01 μm) grains, the large-to-small grain mass ratio becomes smaller by an order of magnitude compared with the initial one. Resulting dust-size distributions depend on the luminosity of the radiation source. The large and small grain segregation becomes weaker when we assume stronger radiation source, since dust grain charges become larger under stronger radiation and hence coulomb drag force becomes stronger.

Sharing reference data and including cows in the reference population improve genomic predictions in Danish Jersey

USDA-ARS?s Scientific Manuscript database

Small reference populations limit the accuracy of genomic prediction in numerically small breeds, such as the Danish Jersey. The objective of this study was to investigate two approaches to improve genomic prediction by increasing the size of the reference population for Danish Jerseys. The first ap...

Distance Education and Training for Small Firms--United Kingdom.

ERIC Educational Resources Information Center

Dey, Ian; Harrison, Jean

This document on the United Kingdom (UK) is one of a series of five monographs published by the European Centre for the Development of Vocational Training (CEDEFOP). The document includes seven chapters, three appendices, and a section of case studies. The first chapter describes small and medium-sized business enterprises in the UK. Vocational…

13 CFR 121.405 - May a business concern self-certify its small business size status?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false May a business concern self-certify its small business size status? 121.405 Section 121.405 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size...

13 CFR 121.1009 - What are the procedures for making the size determination?

Code of Federal Regulations, 2012 CFR

2012-01-01

... the size determination? 121.1009 Section 121.1009 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Procedures for Size.... The concern whose size is under consideration has the burden of establishing its small business size...

13 CFR 121.1009 - What are the procedures for making the size determination?

Code of Federal Regulations, 2013 CFR

2013-01-01

... the size determination? 121.1009 Section 121.1009 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Procedures for Size.... The concern whose size is under consideration has the burden of establishing its small business size...

13 CFR 121.1009 - What are the procedures for making the size determination?

Code of Federal Regulations, 2014 CFR

2014-01-01

... the size determination? 121.1009 Section 121.1009 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Procedures for Size.... The concern whose size is under consideration has the burden of establishing its small business size...

JPL - Small Power Systems Applications Project. [for solar thermal power plant development and commercialization

NASA Technical Reports Server (NTRS)

Ferber, R. R.; Marriott, A. T.; Truscello, V.

1978-01-01

The Small Power Systems Applications (SPSA) Project has been established to develop and commercialize small solar thermal power plants. The technologies of interest include all distributed and central receiver technologies which are potentially economically viable in power plant sizes of one to 10 MWe. The paper presents an overview of the SPSA Project and briefly discusses electric utility involvement in the Project.

A qualitative study of parents' perceptions and use of portion size strategies for preschool children's snacks.

PubMed

Blake, Christine E; Fisher, Jennifer Orlet; Ganter, Claudia; Younginer, Nicholas; Orloski, Alexandria; Blaine, Rachel E; Bruton, Yasmeen; Davison, Kirsten K

2015-05-01

Increases in childhood obesity correspond with shifts in children's snacking behaviors and food portion sizes. This study examined parents' conceptualizations of portion size and the strategies they use to portion snacks in the context of preschool-aged children's snacking. Semi-structured qualitative interviews were conducted with non-Hispanic white (W), African American (AA), and Hispanic (H) low-income parents (n = 60) of preschool-aged children living in Philadelphia and Boston. The interview examined parents' child snacking definitions, purposes, contexts, and frequency. Verbatim transcripts were analyzed using a grounded theory approach. Coding matrices compared responses by race/ethnicity, parent education, and household food security status. Parents' commonly referenced portion sizes when describing children's snacks with phrases like "something small." Snack portion sizes were guided by considerations including healthfulness, location, hunger, and timing. Six strategies for portioning snacks were presented including use of small containers, subdividing large portions, buying prepackaged snacks, use of hand measurement, measuring cups, scales, and letting children determine portion size. Differences in considerations and strategies were seen between race/ethnic groups and by household food security status. Low-income parents of preschool-aged children described a diverse set of considerations and strategies related to portion sizes of snack foods offered to their children. Future studies should examine how these considerations and strategies influence child dietary quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

A qualitative study of parents’ perceptions and use of portion size strategies for preschool children’s snacks

PubMed Central

Blake, Christine E.; Fisher, Jennifer Orlet; Ganter, Claudia; Younginer, Nicholas; Orloski, Alexandria; Blaine, Rachel E.; Bruton, Yasmeen; Davison, Kirsten K.

2014-01-01

Objective Increases in childhood obesity correspond with shifts in children’s snacking behaviors and food portion sizes. This study examined parents’ conceptualizations of portion size and the strategies they use to portion snacks in the context of preschool-aged children’s snacking. Methods Semi-structured qualitative interviews were conducted with non-Hispanic white (W), African American (AA), and Hispanic (H) low-income parents (n=60) of preschool-aged children living in Philadelphia and Boston. The interview examined parents’ child snacking definitions, purposes, contexts, and frequency. Verbatim transcripts were analyzed using a grounded theory approach. Coding matrices compared responses by race/ethnicity, parent education, and household food security status. Results Parents’ commonly referenced portion sizes when describing children’s snacks with phrases like “something small.” Snack portion sizes were guided by considerations including healthfulness, location, hunger, and timing. Six strategies for portioning snacks were presented including use of small containers, subdividing large portions, buying prepackaged snacks, use of hand measurement, measuring cups, scales, and letting children determine portion size. Differences in considerations and strategies were seen between race/ ethnic groups and by household food security status. Conclusions Low-income parents of preschool-aged children described a diverse set of considerations and strategies related to portion sizes of snack foods offered to their children. Future studies should examine how these considerations and strategies influence child dietary quality. PMID:25447008

Effects of seed predators of different body size on seed mortality in Bornean logged forest.

PubMed

Hautier, Yann; Saner, Philippe; Philipson, Christopher; Bagchi, Robert; Ong, Robert C; Hector, Andy

2010-07-19

The Janzen-Connell hypothesis proposes that seed and seedling enemies play a major role in maintaining high levels of tree diversity in tropical forests. However, human disturbance may alter guilds of seed predators including their body size distribution. These changes have the potential to affect seedling survival in logged forest and may alter forest composition and diversity. We manipulated seed density in plots beneath con- and heterospecific adult trees within a logged forest and excluded vertebrate predators of different body sizes using cages. We show that small and large-bodied predators differed in their effect on con- and heterospecific seedling mortality. In combination small and large-bodied predators dramatically decreased both con- and heterospecific seedling survival. In contrast, when larger-bodied predators were excluded small-bodied predators reduced conspecific seed survival leaving seeds coming from the distant tree of a different species. Our results suggest that seed survival is affected differently by vertebrate predators according to their body size. Therefore, changes in the body size structure of the seed predator community in logged forests may change patterns of seed mortality and potentially affect recruitment and community composition.

Effects of Seed Predators of Different Body Size on Seed Mortality in Bornean Logged Forest

PubMed Central

Hautier, Yann; Saner, Philippe; Philipson, Christopher; Bagchi, Robert; Ong, Robert C.; Hector, Andy

2010-01-01

Background The Janzen-Connell hypothesis proposes that seed and seedling enemies play a major role in maintaining high levels of tree diversity in tropical forests. However, human disturbance may alter guilds of seed predators including their body size distribution. These changes have the potential to affect seedling survival in logged forest and may alter forest composition and diversity. Methodology/Principal Findings We manipulated seed density in plots beneath con- and heterospecific adult trees within a logged forest and excluded vertebrate predators of different body sizes using cages. We show that small and large-bodied predators differed in their effect on con- and heterospecific seedling mortality. In combination small and large-bodied predators dramatically decreased both con- and heterospecific seedling survival. In contrast, when larger-bodied predators were excluded small-bodied predators reduced conspecific seed survival leaving seeds coming from the distant tree of a different species. Conclusions/Significance Our results suggest that seed survival is affected differently by vertebrate predators according to their body size. Therefore, changes in the body size structure of the seed predator community in logged forests may change patterns of seed mortality and potentially affect recruitment and community composition. PMID:20657841

Topological Analysis and Gaussian Decision Tree: Effective Representation and Classification of Biosignals of Small Sample Size.

PubMed

Zhang, Zhifei; Song, Yang; Cui, Haochen; Wu, Jayne; Schwartz, Fernando; Qi, Hairong

2017-09-01

Bucking the trend of big data, in microdevice engineering, small sample size is common, especially when the device is still at the proof-of-concept stage. The small sample size, small interclass variation, and large intraclass variation, have brought biosignal analysis new challenges. Novel representation and classification approaches need to be developed to effectively recognize targets of interests with the absence of a large training set. Moving away from the traditional signal analysis in the spatiotemporal domain, we exploit the biosignal representation in the topological domain that would reveal the intrinsic structure of point clouds generated from the biosignal. Additionally, we propose a Gaussian-based decision tree (GDT), which can efficiently classify the biosignals even when the sample size is extremely small. This study is motivated by the application of mastitis detection using low-voltage alternating current electrokinetics (ACEK) where five categories of bisignals need to be recognized with only two samples in each class. Experimental results demonstrate the robustness of the topological features as well as the advantage of GDT over some conventional classifiers in handling small dataset. Our method reduces the voltage of ACEK to a safe level and still yields high-fidelity results with a short assay time. This paper makes two distinctive contributions to the field of biosignal analysis, including performing signal processing in the topological domain and handling extremely small dataset. Currently, there have been no related works that can efficiently tackle the dilemma between avoiding electrochemical reaction and accelerating assay process using ACEK.

Selection against small males in utero: a test of the Wells hypothesis.

PubMed

Catalano, R; Goodman, J; Margerison-Zilko, C E; Saxton, K B; Anderson, E; Epstein, M

2012-04-01

The argument that women in stressful environments spontaneously abort their least fit fetuses enjoys wide dissemination despite the fact that several of its most intuitive predictions remain untested. The literature includes no tests, for example, of the hypothesis that these mechanisms select against small for gestational age (SGA) males. We apply time-series modeling to 4.9 million California male term births to test the hypothesis that the rate of SGA infants in 1096 weekly birth cohorts varies inversely with labor market contraction, a known stressor of contemporary populations. We find support for the hypothesis that small size becomes less frequent among term male infants when the labor market contracts. Our findings contribute to the evidence supporting selection in utero. They also suggest that research into the association between maternal stress and adverse birth outcomes should acknowledge the possibility that fetal loss may affect findings and their interpretation. Strengths of our analyses include the large number and size of our birth cohorts and our control for autocorrelation. Weaknesses include that we, like nearly all researchers in the field, have no direct measure of fetal loss.

Investigation of small solar system objects with the space telescope

NASA Technical Reports Server (NTRS)

Morrison, D.

1979-01-01

The application of the space telescope (ST) to study small objects in the solar system in order to understand the birth and the early evolution of the solar system is discussed. The upper size limit of the small bodies is defined as approximately 5000 km and includes planetary satellites, planetary rings, asteroids, and comets.The use of the astronomical instruments aboard the ST, such as the faint object camera, ultraviolet and infrared spectrometers, and spectrophotometers, to study the small solar system objects is discussed.

Adjustable speed drive study, part 1

NASA Astrophysics Data System (ADS)

Wallace, A.

1989-08-01

Advances in speed control for motors in recent years, notably those in power electronics, have widened the range of application for several adjustable speed drive (ASD) types to include the smaller horsepower sizes. The dc motor drive, formerly in almost universal use for speed control, is being challenged by the high efficiency induction motor/pulse width modulation (PWM) drive; and for special small horsepower size applications, by the permanent magnet motor/PWM inverter drive or by the switched reluctance motor drive. The main characteristics of the several ASD types suitable for small horsepower size applications are discussed, as well as their unwanted side effects: poor power factor, harmonic distortion of the supply, acoustic noise, and electromagnetic interference. A procedure is recommended for determining which, if any, ASD to use.

Prognostic significance of lesion size for glioblastoma multiforme.

PubMed

Reeves, G I; Marks, J E

1979-08-01

From March 1974 to December 1976, 56 patients with glioblastoma multiforme had precraniotomy computed tomography (CT) scans from which the lesion size was determined by measuring the cross-sectional area. Thirty-two patients underwent surgery followed by irradiation, and 24 had surgery followed by irradiation and chemotherapy. There was no difference in survival between the 16 patients with small lesions and the 16 patients with large lesions in the surgery plus radiation alone group, nor in the 16 patients with small and 8 patients with large lesions in the surgery, radiation and chemotherapy group. Minimum follow-up was one year. Other possible prognostic factors including age, tumor grade, radiation dose, and performance status were comparable for each subgroup. Lesion size in glioblastoma multiforme appears unrelated to prognosis.

77 FR 72702 - Small Business Size Standards: Information

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-06

... SMALL BUSINESS ADMINISTRATION 13 CFR Part 121 RIN 3245-AG26 Small Business Size Standards: Information AGENCY: U.S. Small Business Administration. ACTION: Final rule. SUMMARY: The United States Small Business Administration (SBA) is increasing the receipts based small business size standards for 15...

The single mirror small sized telescope for the Cherenkov telescope array

NASA Astrophysics Data System (ADS)

Heller, M.; Schioppa, E., Jr.; Porcelli, A.; Pujadas, I. Troyano; Ziętara, K.; Della Volpe, D.; Montaruli, T.; Cadoux, F.; Favre, Y.; Aguilar, J. A.; Christov, A.; Prandini, E.; Rajda, P.; Rameez, M.; Bilnik, W.; Błocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Frankowski, A.; Grudzińska, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandat, D.; Marszałek, A.; Miranda, L. D. Medina; Michałowski, J.; Moderski, R.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Schovanek, P.; Seweryn, K.; Sliusar, V.; Skowron, K.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Walter, R.; Więcek, M.; Zagdański, A.; CTA Consortium

2017-01-01

The Small Size Telescope with Single Mirror (SST-1M) is one of the proposed types of Small Size Telescopes (SST) for the Cherenkov Telescope Array (CTA). About 70 SST telescopes will be part the CTA southern array which will also include Medium Sized Telescopes (MST) in its threshold configuration. Optimized for the detection of gamma rays in the energy range from 5 TeV to 300 TeV, the SST-1M uses a Davies-Cotton optics with a 4 m dish diameter with a field of view of 9°. The Cherenkov light resulting from the interaction of the gamma-rays in the atmosphere is focused onto a 88 cm side-to-side hexagonal photo-detection plane. The latter is composed of 1296 hollow light guides coupled to large area hexagonal silicon photomultipliers (SiPM). The SiPM readout is fully digital readout as for the trigger system. The compact and lightweight design of the SST-1M camera offiers very high performance ideal for gamma-ray observation requirement. In this contribution, the concept, design, performance and status of the first telescope prototype are presented.

Reserve size and fragmentation alter community assembly, diversity, and dynamics.

PubMed

Lasky, Jesse R; Keitt, Timothy H

2013-11-01

Researchers have disputed whether a single large habitat reserve will support more species than many small reserves. However, relatively little is known from a theoretical perspective about how reserve size affects competitive communities structured by spatial abiotic gradients. We investigate how reserve size affects theoretical communities whose assembly is governed by dispersal limitation, abiotic niche differentiation, and source-sink dynamics. Simulations were conducted with varying scales of dispersal across landscapes with variable environmental spatial autocorrelation. Landscapes were inhabited by simulated trees with seedling and adult stages. For a fixed total area in reserves, we found that small reserve systems increased the distance between environments dominated by different species, diminishing the effects of source-sink dynamics. As reserve size decreased, environmental limitations to community assembly became stronger, α species richness decreased, and γ richness increased. When dispersal occurred across short distances, a large reserve strategy caused greater stochastic community variation, greater α richness, and lower γ richness than in small reserve systems. We found that reserve size variation trades off between preserving different aspects of natural communities, including α diversity versus γ diversity. Optimal reserve size will depend on the importance of source-sink dynamics and the value placed on different characteristics of natural communities. Anthropogenic changes to the size and separation of remnant habitats can have far-reaching effects on community structure and assembly.

Unit bias. A new heuristic that helps explain the effect of portion size on food intake.

PubMed

Geier, Andrew B; Rozin, Paul; Doros, Gheorghe

2006-06-01

People seem to think that a unit of some entity (with certain constraints) is the appropriate and optimal amount. We refer to this heuristic as unit bias. We illustrate unit bias by demonstrating large effects of unit segmentation, a form of portion control, on food intake. Thus, people choose, and presumably eat, much greater weights of Tootsie Rolls and pretzels when offered a large as opposed to a small unit size (and given the option of taking as many units as they choose at no monetary cost). Additionally, they consume substantially more M&M's when the candies are offered with a large as opposed to a small spoon (again with no limits as to the number of spoonfuls to be taken). We propose that unit bias explains why small portion sizes are effective in controlling consumption; in some cases, people served small portions would simply eat additional portions if it were not for unit bias. We argue that unit bias is a general feature in human choice and discuss possible origins of this bias, including consumption norms.

77 FR 8020 - Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... Size 3245-AG25 Standards for Utilities Industries. 463 Small Business Size 3245-AG26 Standards... Remediation Services Industries. 465 Small Business Size 3245-AG28 Standards: Real Estate, Rental and Leasing Industries. 466 Small Business Size 3245-AG29 Standards: Educational Services Industries. 467 Small Business...

75 FR 61597 - Small Business Size Standards: Retail Trade

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... SMALL BUSINESS ADMINISTRATION 13 CFR Part 121 RIN 3245-AF69 Small Business Size Standards: Retail Trade AGENCY: U.S. Small Business Administration. ACTION: Final rule. SUMMARY: The United States Small Business Administration (SBA) is modifying 47 small business size standards for industries in North...

75 FR 61591 - Small Business Size Standards; Other Services.

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... SMALL BUSINESS ADMINISTRATION 13 CFR Part 121 RIN 3245-AF70 Small Business Size Standards; Other Services. AGENCY: U.S. Small Business Administration. ACTION: Final rule. SUMMARY: The United States Small Business Administration (SBA) is increasing the small business size standards for 18 industries in North...

The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings.

PubMed

Lorca-Puls, Diego L; Gajardo-Vidal, Andrea; White, Jitrachote; Seghier, Mohamed L; Leff, Alexander P; Green, David W; Crinion, Jenny T; Ludersdorfer, Philipp; Hope, Thomas M H; Bowman, Howard; Price, Cathy J

2018-07-01

This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We then randomly drew thousands of bootstrap samples from this data set that included either 30, 60, 90, 120, 180, or 360 patients. For each resample, we recorded effect size estimates and p values after conducting exactly the same lesion-deficit analysis within the previously identified region of interest and holding all procedures constant. The results show (1) how often small effect sizes in a heterogeneous population fail to be detected; (2) how effect size and its statistical significance varies with sample size; (3) how low-powered studies (due to small sample sizes) can greatly over-estimate as well as under-estimate effect sizes; and (4) how large sample sizes (N ≥ 90) can yield highly significant p values even when effect sizes are so small that they become trivial in practical terms. The implications of these findings for interpreting the results from univariate voxel-based lesion-deficit analyses are discussed. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Microfluidic interconnects

DOEpatents

Benett, William J.; Krulevitch, Peter A.

2001-01-01

A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with .mu.l-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.

Comparison of Flattening Filter (FF) and Flattening-Filter-Free (FFF) 6 MV photon beam characteristics for small field dosimetry using EGSnrc Monte Carlo code

NASA Astrophysics Data System (ADS)

Sangeetha, S.; Sureka, C. S.

2017-06-01

The present study is focused to compare the characteristics of Varian Clinac 600 C/D flattened and unflattened 6 MV photon beams for small field dosimetry using EGSnrc Monte Carlo Simulation since the small field dosimetry is considered to be the most crucial and provoking task in the field of radiation dosimetry. A 6 MV photon beam of a Varian Clinac 600 C/D medical linear accelerator operates with Flattening Filter (FF) and Flattening-Filter-Free (FFF) mode for small field dosimetry were performed using EGSnrc Monte Carlo user codes (BEAMnrc and DOSXYZnrc) in order to calculate the beam characteristics using Educated-trial and error method. These includes: Percentage depth dose, lateral beam profile, dose rate delivery, photon energy spectra, photon beam uniformity, out-of-field dose, surface dose, penumbral dose and output factor for small field dosimetry (0.5×0.5 cm2 to 4×4 cm2) and are compared with magna-field sizes (5×5 cm2 to 40×40 cm2) at various depths. The results obtained showed that the optimized beam energy and Full-width-half maximum value for small field dosimetry and magna-field dosimetry was found to be 5.7 MeV and 0.13 cm for both FF and FFF beams. The depth of dose maxima for small field size deviates minimally for both FF and FFF beams similar to magna-fields. The depths greater than dmax depicts a steeper dose fall off in the exponential region for FFF beams comparing FF beams where its deviations gets increased with the increase in field size. The shape of the lateral beam profiles of FF and FFF beams varies remains similar for the small field sizes less than 4×4 cm2 whereas it varies in the case of magna-fields. Dose rate delivery for FFF beams shows an eminent increase with a two-fold factor for both small field dosimetry and magna-field sizes. The surface dose measurements of FFF beams for small field size were found to be higher whereas it gets lower for magna-fields than FF beam. The amount of out-of-field dose reduction gets increased with the increase in field size. It is also observed that the photon energy spectrum gets increased with the increase in field size for FFF beam mode. Finally, the output factors for FFF beams were relatively quite low for small field sizes than FF beams whereas it gets higher for magna-field sizes. From this study, it is concluded that the FFF beams depicted minimal deviations in the treatment field region irrespective to the normal tissue region for small field dosimetry compared to FF beams. The more prominent result observed from the study is that the shape of the beam profile remains similar for FF and FFF beams in the case of smaller field size that leads to more accurate treatment planning in the case of IMRT (Image-Guided Radiation Therapy), IGAT (Image-Guided Adaptive Radiation Therapy), SBRT (Stereotactic Body Radiation Therapy), SRS (Stereotactic Radio Surgery), and Tomotherapy techniques where homogeneous dose is not necessary. On the whole, the determination of dosimetric beam characteristics of Varian linac machine using Monte Carlo simulation provides accurate dose calculation as the clinical golden data.

The Optimal Size for Discussion Groups. Exchange Bibliography No. 378.

ERIC Educational Resources Information Center

Petty, Robert M.

Many variables relate to the successful functioning of groups, but one that is fundamental is the size of the group. Part 1 of this bibliography includes a selection of studies from small-group research in experimental social psychology. Part 2 of this report represents an attempt at a rigorous review of the feelings of clinicians and counselors…

Protection of obstetric dimensions in a small-bodied human sample.

PubMed

Kurki, Helen K

2007-08-01

In human females, the bony pelvis must find a balance between being small (narrow) for efficient bipedal locomotion, and being large to accommodate a relatively large newborn. It has been shown that within a given population, taller/larger-bodied women have larger pelvic canals. This study investigates whether in a population where small body size is the norm, pelvic geometry (size and shape), on average, shows accommodation to protect the obstetric canal. Osteometric data were collected from the pelves, femora, and clavicles (body size indicators) of adult skeletons representing a range of adult body size. Samples include Holocene Later Stone Age (LSA) foragers from southern Africa (n = 28 females, 31 males), Portuguese from the Coimbra-identified skeletal collection (CISC) (n = 40 females, 40 males) and European-Americans from the Hamann-Todd osteological collection (H-T) (n = 40 females, 40 males). Patterns of sexual dimorphism are similar in the samples. Univariate and multivariate analyses of raw and Mosimann shape-variables indicate that compared to the CISC and H-T females, the LSA females have relatively large midplane and outlet canal planes (particularly posterior and A-P lengths). The LSA males also follow this pattern, although with absolutely smaller pelves in multivariate space. The CISC females, who have equally small stature, but larger body mass, do not show the same type of pelvic canal size and shape accommodation. The results suggest that adaptive allometric modeling in at least some small-bodied populations protects the obstetric canal. These findings support the use of population-specific attributes in the clinical evaluation of obstetric risk. (c) 2007 Wiley-Liss, Inc.

78 FR 37404 - Small Business Size Standards: Support Activities for Mining

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... SMALL BUSINESS ADMINISTRATION 13 CFR Part 121 RIN 3245-AG44 Small Business Size Standards: Support Activities for Mining AGENCY: U.S. Small Business Administration. ACTION: Final rule. SUMMARY: The United States Small Business Administration (SBA) is increasing the small business size standards for three of...

76 FR 69154 - Small Business Size and Status Integrity

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-08

... SMALL BUSINESS ADMINISTRATION 13 CFR Parts 121, 124, 125, 126, and 127 RIN 3245-AG23 Small Business Size and Status Integrity AGENCY: U.S. Small Business Administration (SBA). ACTION: Proposed rule... implement provisions of the Small Business Jobs Act of 2010 (Jobs Act) pertaining to small business size and...

48 CFR 52.219-21 - Small Business Size Representation for Targeted Industry Categories Under the Small Business...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Small Business Size Representation for Targeted Industry Categories Under the Small Business Competitiveness Demonstration Program....219-21 Small Business Size Representation for Targeted Industry Categories Under the Small Business...

Ecological specialization and morphological diversification in Greater Antillean boas.

PubMed

Reynolds, R Graham; Collar, David C; Pasachnik, Stesha A; Niemiller, Matthew L; Puente-Rolón, Alberto R; Revell, Liam J

2016-08-01

Colonization of islands can dramatically influence the evolutionary trajectories of organisms, with both deterministic and stochastic processes driving adaptation and diversification. Some island colonists evolve extremely large or small body sizes, presumably in response to unique ecological circumstances present on islands. One example of this phenomenon, the Greater Antillean boas, includes both small (<90 cm) and large (4 m) species occurring on the Greater Antilles and Bahamas, with some islands supporting pairs or trios of body-size divergent species. These boas have been shown to comprise a monophyletic radiation arising from a Miocene dispersal event to the Greater Antilles, though it is not known whether co-occurrence of small and large species is a result of dispersal or in situ evolution. Here, we provide the first comprehensive species phylogeny for this clade combined with morphometric and ecological data to show that small body size evolved repeatedly on separate islands in association with specialization in substrate use. Our results further suggest that microhabitat specialization is linked to increased rates of head shape diversification among specialists. Our findings show that ecological specialization following island colonization promotes morphological diversity through deterministic body size evolution and cranial morphological diversification that is contingent on island- and species-specific factors. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

Use of care management practices in small- and medium-sized physician groups: do public reporting of physician quality and financial incentives matter?

PubMed

Alexander, Jeffrey A; Maeng, Daniel; Casalino, Lawrence P; Rittenhouse, Diane

2013-04-01

To examine the effect of public reporting (PR) and financial incentives tied to quality performance on the use of care management practices (CMPs) among small- and medium-sized physician groups. Survey data from The National Study of Small and Medium-sized Physician Practices were used. Primary data collection was also conducted to assess community-level PR activities. The final sample included 643 practices engaged in quality reporting; about half of these practices were subject to PR. We used a treatment effects model. The instrumental variables were the community-level variables that capture the level of PR activity in each community in which the practices operate. (1) PR is associated with increased use of CMPs, but the estimate is not statistically significant; (2) financial incentives are associated with greater use of CMPs; (3) practices' awareness/sensitivity to quality reports is positively related to their use of CMPs; and (4) combined PR and financial incentives jointly affect CMP use to a greater degree than either of these factors alone. Small- to medium-sized practices appear to respond to PR and financial incentives by greater use of CMPs. Future research needs to investigate the appropriate mix and type of incentive arrangements and quality reporting. © Health Research and Educational Trust.

Miniature personal UV solar dosimeter

NASA Technical Reports Server (NTRS)

Adams, R. R.; Macconochie, I. O.; Poole, B. D., Jr.

1981-01-01

Small light-powered meter measures accumulated radiation in ultraviolet or other selected regions. Practical advantages are device's low cost, small size, accuracy, and adaptability to specific wave-band measurements. Medical applications include detection of skin cancer, vitamin D production, and jaundice. Dosimeter also measures sunlight for solar energy designs, agriculture and meteorology, and monitors stability of materials and environmental and occupational lighting.

Trembling aspen response to a mixed-severity wildfire in the Black Hills, South Dakota, USA

Treesearch

Tara L. Keyser; Frederick W. Smith; Wayne D. Shepperd

2005-01-01

Trembling aspen (Populus tremuloides Michx.) regeneration dynamics including sprout production, growth, and clone size were measured to determine the effects of fire on small aspen clone persistence following a mixedseverity wildfire in the Black Hills, South Dakota. Four years postfire, 10 small, isolated aspen clones per low and high fire severity...

Laser diffraction particle sizing in STRESS

NASA Astrophysics Data System (ADS)

Agrawal, Y. C.; Pottsmith, H. C.

1994-08-01

An autonomous instrument system for measuring particle size spectra in the sea is described. The instrument records the small-angle scattering characteristics of the particulate ensemble present in water. The small-angle scattering distribution is inverted into size spectra. The discussion of the instrument in this paper is included with a review of the information content of the data. It is noted that the inverse problem is sensitive to the forward model for light scattering employed in the construction of the matrix. The instrument system is validated using monodisperse polystyrene and NIST standard distributions of glass spheres. Data from a long-term deployment on the California shelf during the field experiment Sediment Transport Events on Shelves and Slopes (STRESS) are included. The size distribution in STRESS, measured at a fixed height-above-bed 1.2 m, showed significant variability over time. In particular, the volume distribution sometimes changed from mono-modal to bi-modal during the experiment. The data on particle-size distribution are combined with friction velocity measurements in the current boundary layer to produce a size-dependent estimate of the suspended mass at 10 cm above bottom. It is argued that these concentrations represent the reference concentration at the bed for the smaller size classes. The suspended mass at all sizes shows a strong correlation with wave variance. Using the size distribution, corrections in the optical transmissometry calibration factor are estimated for the duration of the experiment. The change in calibration at 1.2 m above bed (mab) is shown to have a standard error of 30% over the duration of the experiment with a range of 1.8-0.8.

Size effects in non-linear heat conduction with flux-limited behaviors

NASA Astrophysics Data System (ADS)

Li, Shu-Nan; Cao, Bing-Yang

2017-11-01

Size effects are discussed for several non-linear heat conduction models with flux-limited behaviors, including the phonon hydrodynamic, Lagrange multiplier, hierarchy moment, nonlinear phonon hydrodynamic, tempered diffusion, thermon gas and generalized nonlinear models. For the phonon hydrodynamic, Lagrange multiplier and tempered diffusion models, heat flux will not exist in problems with sufficiently small scale. The existence of heat flux needs the sizes of heat conduction larger than their corresponding critical sizes, which are determined by the physical properties and boundary temperatures. The critical sizes can be regarded as the theoretical limits of the applicable ranges for these non-linear heat conduction models with flux-limited behaviors. For sufficiently small scale heat conduction, the phonon hydrodynamic and Lagrange multiplier models can also predict the theoretical possibility of violating the second law and multiplicity. Comparisons are also made between these non-Fourier models and non-linear Fourier heat conduction in the type of fast diffusion, which can also predict flux-limited behaviors.

A deployable mechanism concept for the collection of small-to-medium-size space debris

NASA Astrophysics Data System (ADS)

St-Onge, David; Sharf, Inna; Sagnières, Luc; Gosselin, Clément

2018-03-01

Current efforts in active debris removal strategies and mission planning focus on removing the largest, most massive debris. It can be argued, however, that small untrackable debris, specifically those smaller than 5 cm in size, also pose a serious threat. In this work, we propose and analyze a mission to sweep the most crowded Low Earth Orbit with a large cupola device to remove small-to-medium-size debris. The cupola consists of a deployable mechanism expanding more than 25 times its storage size to extend a membrane covering its surface. The membrane is sufficiently stiff to capture most small debris and to slow down the medium-size objects, thus accelerating their fall. An overview of the design of a belt-driven rigid-link mechanism proposed to support the collecting cupola surface is presented, based on our previous work. Because of its large size, the cupola will be subject to significant aerodynamic drag; thus, orbit maintenance analysis is carried out using the DTM-2013 atmospheric density model and it predicts feasible requirements. While in operation, the device will also be subject to numerous hyper-velocity impacts which may significantly perturb its orientation from the desired attitude for debris collection. Thus, another important feature of the proposed debris removal device is a distributed array of flywheels mounted on the cupola for reorienting and stabilizing its attitude during the mission. Analysis using a stochastic modeling framework for hyper-velocity impacts demonstrates that three-axes attitude stabilization is achievable with the flywheels array. MASTER-2009 software is employed to provide relevant data for all debris related estimates, including the debris fluxes for the baseline mission design and for assessment of its expected performance. Space debris removal is a high priority for ensuring sustainability of space and continual launch and operation of man-made space assets. This manuscript presents the first analysis of a small-to-medium size debris removal mission, albeit finding it to not be economically viable at the present time.

Prognostic Factors Affecting Rotator Cuff Healing After Arthroscopic Repair in Small to Medium-sized Tears.

PubMed

Park, Ji Soon; Park, Hyung Jun; Kim, Sae Hoon; Oh, Joo Han

2015-10-01

Small and medium-sized rotator cuff tears usually have good clinical and anatomic outcomes. However, healing failure still occurs in some cases. To evaluate prognostic factors for rotator cuff healing in patients with only small to medium-sized rotator cuff tears. Case-control study; Level of evidence, 3. Data were prospectively collected from 339 patients with small to medium-sized rotator cuff tears who underwent arthroscopic repair by a single surgeon between March 2004 and August 2012 and who underwent magnetic resonance imaging or computed tomographic arthrography at least 1 year after surgery. The mean age of the patients was 59.8 years (range, 39-80 years), and the mean follow-up time was 20.8 months (range, 12-66 months). The functional evaluation included the visual analog scale (VAS) for pain, American Shoulder and Elbow Surgeons score, Constant-Murley score, and Simple Shoulder Test. Postoperative VAS for pain and functional scores improved significantly compared with preoperative values (P < .001). Forty-five healing failures occurred (13.3%), and fatty degeneration of the infraspinatus muscle, tear size (anteroposterior dimension), and age were significant factors affecting rotator cuff healing (P < .001, = .018, and = .011, respectively) in multivariate logistic regression analysis. Grade II and higher infraspinatus fatty degeneration correlated with a higher failure rate. The failure rate was also significantly higher in patients with a tear >2 cm in size (34.2%) compared with patients with a tear ≤2 cm (10.6%) (P < .001). A receiver operating characteristic curve was used to determine the predictive cut-off value for the oldest age and the largest tear size for successful healing, which were calculated as 69 years and 2 cm, respectively, with a specificity of 90%. In small to medium-sized rotator cuff tears, grade II fatty degeneration of the infraspinatus muscle according to the Goutallier classification could be a reference point for successful healing, and anatomic outcomes might be better if repair is performed before the patient is 69 years old and the tear size exceeds 2 cm. © 2015 The Author(s).

77 FR 39442 - Receipts-Based, Small Business Size Standard

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... RIN 3150-AJ14 [NRC-2012-0062] Receipts-Based, Small Business Size Standard AGENCY: Nuclear Regulatory... business size standard from $6.5 million to $7 million to conform to the standard set by the Small Business... updating the receipts-based, small business size standard from $6.5 million to $7.0 million. Adequate...

Does Graft Particle Type and Size Affect Ridge Dimensional Changes After Alveolar Ridge Split Procedure?

PubMed

Kheur, Mohit G; Kheur, Supriya; Lakha, Tabrez; Jambhekar, Shantanu; Le, Bach; Jain, Vinay

2018-04-01

The absence of an adequate volume of bone at implant sites requires augmentation procedures before the placement of implants. The aim of the present study was to assess the ridge width gain with the use of allografts and biphasic β-tricalcium phosphate with hydroxyapatite (alloplast) in ridge split procedures, when each were used in small (0.25 to 1 mm) and large (1 to 2 mm) particle sizes. A randomized controlled trial of 23 subjects with severe atrophy of the mandible in the horizontal dimension was conducted in a private institute. The patients underwent placement of 49 dental implants after a staged ridge split procedure. The patients were randomly allocated to alloplast and allograft groups (predictor variable). In each group, the patients were randomly assigned to either small graft particle or large graft particle size (predictor variable). The gain in ridge width (outcome variable) was assessed before implant placement. A 2-way analysis of variance test and the Student unpaired t test were used for evaluation of the ridge width gain between the allograft and alloplast groups (predictor variable). Differences were considered significant if P values were < .05. The sample included 23 patients (14 men and 9 women). The patients were randomly allocated to the alloplast (n = 11) or allograft (n = 12) group before the ridge split procedure. In each group, they were assigned to a small graft particle or large graft particle size (alloplast group, small particle in 5 and large particle size in 6 patients; allograft group, small particle in 6 and large particle size in 6). A statistically significant difference was observed between the 2 graft types. The average ridge width gain was significantly greater in the alloplast group (large, 4.40 ± 0.24 mm; small, 3.52 ± 0.59 mm) than in the allograft group (large, 3.82 ± 0.19 mm; small, 2.57 ± 0.16 mm). For both graft types (alloplast and allograft), the large particle size graft resulted in a greater ridge width gain compared with the small particle size graft (P < .05). Within the limitations of the present study, we suggest the use of large particle alloplast as the graft material of choice for staged ridge split procedures in the posterior mandible. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients.

PubMed

Kotani, Kazuhiko; Tsuzaki, Kokoro; Taniguchi, Nobuyuki; Sakane, Naoki

2012-03-01

Small dense low-density lipoprotein (sdLDL) which has a small LDL particle size with greater susceptibility to oxidation is regarded as a risk marker for cardiovascular disease. The diacron reactive oxygen metabolites (d-ROMs) test has recently been introduced as an oxidative stress-related marker in the clinic. The aim of the present study was to investigate the correlation between the mean LDL particle size and the oxidative stress status as evaluated by the d-ROMs in dyslipidemic patients. The study included 278 dyslipidemic patients (121 male and 157 female, mean age, 60 years). Clinical data including the conventional atherosclerotic risk factors in addition to the mean LDL particle size measured with the gel electrophoresis and the d-ROMs were collected. Male patients had a significantly smaller mean LDL particle size than females (262.2 ± 7.5 [SD] vs. 264.3 ± 6.7 Å, P<0.05), while female patients had a significantly higher d-ROMs level than males (318 ± 68 vs. 350 ± 72 U. Carr., P<0.01). A multiple regression analysis revealed that there was an independent, significant, and inverse correlation between the mean LDL particle size and the d-ROMs (β=-0.19, P<0.05). These findings of the co-existence of both markers suggest that sdLDL and oxidative stress can be cooperative in atherogenesis, possibly leading to the incidence of CVD, in dyslipidemic patients.

Meta-analysis and systematic review of studies on the effectiveness of HIV stigma reduction programs.

PubMed

Mak, Winnie W S; Mo, Phoenix K H; Ma, Gloria Y K; Lam, Maggie Y Y

2017-09-01

The present study conducted a meta-analysis and systematic review on studies evaluating the effectiveness of stigma reduction programs in improving knowledge and reducing negative attitudes towards people living with HIV (PLHIV). Meta-analysis (k = 42 studies) found significant and small effect sizes in the improvement of the participants' knowledge of HIV/AIDS from interventions with (Cohen's d = 0.48, 95% CI [0.30, 0.66]) and without control groups (Cohen's d = 0.42, 95% CI [0.28, 0.57]). Significant and small effect sizes were found in the improvement of the participants' attitudes toward PLHIV from interventions with (Cohen's d = 0.39, 95% CI [0.23, 0.55]) and without control groups (Cohen's d = 0.25, 95% CI [0.11, 0.39]). Significant and small effect sizes were sustained at the follow-up assessments. Subgroup analysis showed that number of intervention sessions, intervention settings, and sample type significantly moderated the effect sizes in the meta-analysis. Findings from the systematic review of 35 studies indicated that most of the included studies showed positive results in reducing negative attitudes toward PLHIV and improving HIV-related knowledge. Most of the included studies tended to have low methodological quality. The present meta-analysis and systematic review indicated that the studies generally found small improvement in HIV-related knowledge and reduction in negative attitudes towards PLHIV among the stigma reduction programs being evaluated. High-quality stigma reduction programs with multidimensional stigma indicators and psychometrically sound outcome measures are highly warranted. Copyright © 2017 Elsevier Ltd. All rights reserved.

A small, sensitive, light-weight, and disposable aerosol spectrometer for balloon and UAV applications

NASA Astrophysics Data System (ADS)

Fahey, D. W.; Gao, R.; Thornberry, T. D.; Rollins, D. W.; Schwarz, J. P.; Perring, A. E.

2013-12-01

In-situ sampling with particle size spectrometers is an important method to provide detailed size spectra for atmospheric aerosol in the troposphere and stratosphere. The spectra are essential for understanding aerosol sources and aerosol chemical evolution and removal, and for aerosol remote sensing validation. These spectrometers are usually bulky, heavy, and expensive, thereby limiting their application to specific airborne platforms. Here we report a new type of small and light-weight optical aerosol particle size spectrometer that is sensitive enough for many aerosol applications yet is inexpensive enough to be disposable. 3D printing is used for producing structural components for simplicity and low cost. Weighing less than 1 kg individually, we expect these spectrometers can be deployed successfully on small unmanned aircraft systems (UASs) and up to 25 km on weather balloons. Immediate applications include the study of Arctic haze using the Manta UAS, detection of the Asian Tropopause Aerosol Layer in the Asian monsoon system and SAGE III validation onboard weather balloons.

Adjustable speed drive study, June 1985 to September 1988. Part 2: Appendices

NASA Astrophysics Data System (ADS)

Wallace, Alan

1989-08-01

Advances in speed control for motors in recent years, notably those in power electronics, have widened the range of application for several adjustable speed drive (ASD) types to include the smaller horsepower sizes. The dc motor drive, formerly in almost universal use for speed control, is being challenged by the high efficiency induction motor/pulse width modulation (PWM) drive; and for special small horsepower size applications, by the permanent magnet motor/PWM inverter drive or by the switched reluctance motor drive. The main characteristics of the several ASD types suitable for small horsepower size applications are discussed, as well as their unwanted side effects: poor power factor, harmonic distortion of the supply, acoustic noise, and electromagnetic interference. A procedure is recommended for determining which, if any, ASD to use.

Lumped element filters for electronic warfare systems

NASA Astrophysics Data System (ADS)

Morgan, D.; Ragland, R.

1986-02-01

Increasing demands which future generations of electronic warfare (EW) systems are to satisfy include a reduction in the size of the equipment. The present paper is concerned with lumped element filters which can make a significant contribution to the downsizing of advanced EW systems. Lumped element filter design makes it possible to obtain very small package sizes by utilizing classical low frequency inductive and capacitive components which are small compared to the size of a wavelength. Cost-effective, temperature-stable devices can be obtained on the basis of new design techniques. Attention is given to aspects of design flexibility, an interdigital filter equivalent circuit diagram, conditions for which the use of lumped element filters can be recommended, construction techniques, a design example, and questions regarding the application of lumped element filters to EW processing systems.

Freeze-frame fruit selection by birds

USGS Publications Warehouse

Foster, Mercedes S.

2008-01-01

The choice of fruits by an avian frugivore is affected by choices it makes at multiple hierarchical levels (e.g., species of fruit, individual tree, individual fruit). Factors that influence those choices vary among levels in the hierarchy and include characteristics of the environment, the tree, and the fruit itself. Feeding experiments with wild-caught birds were conducted at El Tirol, Departamento de Itapua, Paraguay to test whether birds were selecting among individual fruits based on fruit size. Feeding on larger fruits, which have proportionally more pulp, is generally more efficient than feeding on small fruits. In trials (n = 56) with seven species of birds in four families, birds selected larger fruits 86% of the time. However, in only six instances were size differences significant, which is likely a reflection of small sample sizes.

Association between hospital size and quality improvement for pharmaceutical services.

PubMed

Nau, David P; Garber, Mathew C; Lipowski, Earlene E; Stevenson, James G

2004-01-15

The relationship between hospital size and quality improvement (QI) for pharmaceutical services was studied. A questionnaire on QI was sent to hospital pharmacy directors in Michigan and Florida in 2002. The questionnaire included items on QI lead-team composition, QI tools, QI training, and QI culture. Usable responses were received from 162 (57%) of 282 pharmacy directors. Pharmacy QI lead teams were present in 57% of institutions, with larger teams in large hospitals (> or = 300 patients). Only two QI tools were used by a majority of hospitals: root-cause analysis (62%) and flow charts (66%). Small hospitals (< 50 patients) were less likely than medium-sized hospitals (50-299 patients) and large hospitals to use several QI tools, including control charts, cause-and-effect diagrams, root-cause analysis, flow charts, and histograms. Large hospitals were more likely than small and medium-sized hospitals to use root-cause analysis and control charts. There was no relationship between hospital size and the frequency with which physician or patient satisfaction with pharmaceutical services was measured. There were no differences in QI training or QI culture across hospital size categories. A survey suggested that a majority of hospital pharmacies in Michigan and Florida have begun to adopt QI techniques but that most are not using rigorous QI tools. Pharmacies in large hospitals had more QI lead-team members and were more likely to use certain QI tools, but there was no relationship between hospital size and satisfaction measurements, QI training, or QI culture.

76 FR 27952 - Small Business Size Standards: Professional, Scientific and Technical Services.

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... Administration (SBA or Agency) proposed to increase small business size standards for 35 industries and one sub... SMALL BUSINESS ADMINISTRATION 13 CFR Part 121 RIN 3245-AG07 Small Business Size Standards: Professional, Scientific and Technical Services. AGENCY: U.S. Small Business Administration. ACTION: Proposed...

Body shape convergence driven by small size optimum in marine angelfishes.

PubMed

Frédérich, Bruno; Santini, Francesco; Konow, Nicolai; Schnitzler, Joseph; Lecchini, David; Alfaro, Michael E

2017-06-01

Convergent evolution of small body size occurs across many vertebrate clades and may reflect an evolutionary response to shared selective pressures. However it remains unclear if other aspects of phenotype undergo convergent evolution in miniaturized lineages. Here we present a comparative analysis of body size and shape evolution in marine angelfishes (Pomacanthidae), a reef fish family characterized by repeated transitions to small body size. We ask if lineages that evolve small sizes show convergent evolution in body shape. Our results reveal that angelfish lineages evolved three different stable size optima with one corresponding to the group of pygmy angelfishes ( Centropyge ). Then, we test if the observed shifts in body size are associated with changes to new adaptive peaks in shape. Our data suggest that independent evolution to small size optima have induced repeated convergence upon deeper body and steeper head profile in Centropyge These traits may favour manoeuvrability and visual awareness in these cryptic species living among corals, illustrating that functional demands on small size may be related to habitat specialization and predator avoidance. The absence of shape convergence in large marine angelfishes also suggests that more severe requirements exist for small than for large size optima. © 2017 The Author(s).

Molecular Diffusion Coefficients: Experimental Determination and Demonstration.

ERIC Educational Resources Information Center

Fate, Gwendolyn; Lynn, David G.

1990-01-01

Presented are laboratory methods which allow the demonstration and determination of the diffusion coefficients of compounds ranging in size from water to small proteins. Included are the procedures involving the use of a spectrometer, UV cell, triterated agar, and oxygen diffusion. Results including quantification are described. (CW)

Longitudinal Monitoring of Successive Commercial Layer Flocks for Salmonella enterica Serovar Enteritidis.

PubMed

Denagamage, Thomas N; Patterson, Paul; Wallner-Pendleton, Eva; Trampel, Darrell; Shariat, Nikki; Dudley, Edward G; Jayarao, Bhushan M; Kariyawasam, Subhashinie

2016-11-01

The Pennsylvania Egg Quality Assurance Program (EQAP) provided the framework for Salmonella Enteritidis (SE) control programs, including the Food and Drug Administration (FDA) mandated Final Egg Rule, for commercial layer facilities throughout the United States. Although flocks with ≥3000 birds must comply with the FDA Final Egg Rule, smaller flocks are exempted from the rule. As a result, eggs produced by small layer flocks may pose a greater public health risk than those from larger flocks. It is also unknown if the EQAPs developed with large flocks in mind are suitable for small- and medium-sized flocks. Therefore, a study was performed to evaluate the effectiveness of best management practices included in EQAPs in reducing SE contamination of small- and medium-sized flocks by longitudinal monitoring of their environment and eggs. A total of 59 medium-sized (3000 to 50,000 birds) and small-sized (<3000 birds) flocks from two major layer production states of the United States were enrolled and monitored for SE by culturing different types of environmental samples and shell eggs for two consecutive flock cycles. Isolated SE was characterized by phage typing, pulsed-field gel electrophoresis (PFGE), and clustered regularly interspaced short palindromic repeats-multi-virulence-locus sequence typing (CRISPR-MVLST). Fifty-four Salmonella isolates belonging to 17 serovars, 22 of which were SE, were isolated from multiple sample types. Typing revealed that SE isolates belonged to three phage types (PTs), three PFGE fingerprint patterns, and three CRISPR-MVLST SE Sequence Types (ESTs). The PT8 and JEGX01.0004 PFGE pattern, the most predominant SE types associated with foodborne illness in the United States, were represented by a majority (91%) of SE. Of the three ESTs observed, 85% SE were typed as EST4. The proportion of SE-positive hen house environment during flock cycle 2 was significantly less than the flock cycle 1, demonstrating that current EQAP practices were effective in reducing SE contamination of medium and small layer flocks.

Industrial Assessment Centers - Small Manufacturers Reduce Energy & Increase Productivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Since 1976, the Industrial Assessment Centers (IACs), administered by the US Department of Energy, have supported small and medium-sized American manufacturers to reduce energy use and increase their productivity and competitiveness. The 24 IACs, located at premier engineering universities around the country (see below), send faculty and engineering students to local small and medium-sized manufacturers to provide no-cost assessments of energy use, process performance and waste and water flows. Under the direction of experienced professors, IAC engineering students analyze the manufacturer’s facilities, energy bills and energy, waste and water systems, including compressed air, motors/pumps, lighting, process heat and steam. Themore » IACs then follow up with written energy-saving and productivity improvement recommendations, with estimates of related costs and payback periods.« less

Elucidating the Small Regulatory RNA Repertoire of the Sea Anemone Anemonia viridis Based on Whole Genome and Small RNA Sequencing

PubMed Central

Patel, Hardip; Forêt, Sylvain; Karlsen, Bård Ove; Jørgensen, Tor Erik; Hall-Spencer, Jason M

2018-01-01

Abstract Cnidarians harbor a variety of small regulatory RNAs that include microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), but detailed information is limited. Here, we report the identification and expression of novel miRNAs and putative piRNAs, as well as their genomic loci, in the symbiotic sea anemone Anemonia viridis. We generated a draft assembly of the A. viridis genome with putative size of 313 Mb that appeared to be composed of about 36% repeats, including known transposable elements. We detected approximately equal fractions of DNA transposons and retrotransposons. Deep sequencing of small RNA libraries constructed from A. viridis adults sampled at a natural CO2 gradient off Vulcano Island, Italy, identified 70 distinct miRNAs. Eight were homologous to previously reported miRNAs in cnidarians, whereas 62 appeared novel. Nine miRNAs were recognized as differentially expressed along the natural seawater pH gradient. We found a highly abundant and diverse population of piRNAs, with a substantial fraction showing ping–pong signatures. We identified nearly 22% putative piRNAs potentially targeting transposable elements within the A. viridis genome. The A. viridis genome appeared similar in size to that of other hexacorals with a very high divergence of transposable elements resembling that of the sea anemone genus Exaiptasia. The genome encodes and expresses a high number of small regulatory RNAs, which include novel miRNAs and piRNAs. Differentially expressed small RNAs along the seawater pH gradient indicated regulatory gene responses to environmental stressors. PMID:29385567

77 FR 30265 - Submission for OMB Review; Small Business Size Representation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... Information Collection 9000- 0163, Small Business Size Representation, by any of the following methods... Business Size Representation AGENCY: Department of Defense (DOD), General Services Administration (GSA... of a previously approved information collection requirement regarding small business size...

How To Work with Small Businesses: Advice and Guidance for Providers of Training and Business Support.

ERIC Educational Resources Information Center

Allen, Anne Marie, Ed.

This publication provides guidance on good practice to help training providers in the United Kingdom improve the quality and relevance of services to small and medium-sized enterprises (SMEs). Section 1 focuses on key research findings regarding SMEs' needs and SME-college collaboration, including trading conditions for SMEs; services on offer by…

Ultra-modular 500m2 heliostat field for high flux/high temperature solar-driven processes

NASA Astrophysics Data System (ADS)

Romero, Manuel; González-Aguilar, José; Luque, Salvador

2017-06-01

The main objective of the European Project SUN-to-LIQUID is the scale-up and experimental demonstration of the complete process chain to solar liquid fuels from H2O and CO2. This implies moving from a 4 kW laboratory setup to a pre-commercial plant including a heliostat field. The small power and high irradiance onto the focal spot is forcing the optical design to behave half way between a large solar furnace and an extremely small central receiver system. The customized heliostat field makes use of the most recent developments on small size heliostats and a tower with reduced optical height (15 m) to minimize visual impact. A heliostat field of 250kWth (500 m2 reflective surface) has been built adjacent to IMDEA Energy premises at the Technology Park of Móstoles, Spain, and consists of 169 small size heliostats (1.9 m × 1.6 m). In spite of the small size and compactness of the field, when all heliostats are aligned, it is possible to fulfil the specified flux above 2500 kW/m2 for at least 50 kW and an aperture of 16 cm, with a peak flux of 3000 kW/m2.

Conserving Tropical Tree Diversity and Forest Structure: The Value of Small Rainforest Patches in Moderately-Managed Landscapes

PubMed Central

Hernández-Ruedas, Manuel A.; Arroyo-Rodríguez, Víctor; Meave, Jorge A.; Martínez-Ramos, Miguel; Ibarra-Manríquez, Guillermo; Martínez, Esteban; Jamangapé, Gilberto; Melo, Felipe P. L.; Santos, Bráulio A.

2014-01-01

Rainforests are undergoing severe deforestation and fragmentation worldwide. A huge amount of small forest patches are being created, but their value in conserving biodiversity and forest structure is still controversial. Here, we demonstrate that in a species-rich and moderately-managed Mexican tropical landscape small rainforest patches (<100 ha) can be highly valuable for the conservation of tree diversity and forest structure. These patches showed diverse communities of native plants, including endangered species, and a new record for the country. Although the number of logged trees increased in smaller patches, patch size was a poor indicator of basal area, stem density, number of species, genera and families, and community evenness. Cumulative species-area curves indicated that all patches had a similar contribution to the regional species diversity. This idea also was supported by the fact that patches strongly differed in floristic composition (high β-diversity), independently of patch size. Thus, in agreement with the land-sharing approach, our findings support that small forest patches in moderately-managed landscapes should be included in conservation initiatives to maintain landscape heterogeneity, species diversity, and ecosystem services. PMID:24901954

Conserving tropical tree diversity and forest structure: the value of small rainforest patches in moderately-managed landscapes.

PubMed

Hernández-Ruedas, Manuel A; Arroyo-Rodríguez, Víctor; Meave, Jorge A; Martínez-Ramos, Miguel; Ibarra-Manríquez, Guillermo; Martínez, Esteban; Jamangapé, Gilberto; Melo, Felipe P L; Santos, Bráulio A

2014-01-01

Rainforests are undergoing severe deforestation and fragmentation worldwide. A huge amount of small forest patches are being created, but their value in conserving biodiversity and forest structure is still controversial. Here, we demonstrate that in a species-rich and moderately-managed Mexican tropical landscape small rainforest patches (<100 ha) can be highly valuable for the conservation of tree diversity and forest structure. These patches showed diverse communities of native plants, including endangered species, and a new record for the country. Although the number of logged trees increased in smaller patches, patch size was a poor indicator of basal area, stem density, number of species, genera and families, and community evenness. Cumulative species-area curves indicated that all patches had a similar contribution to the regional species diversity. This idea also was supported by the fact that patches strongly differed in floristic composition (high β-diversity), independently of patch size. Thus, in agreement with the land-sharing approach, our findings support that small forest patches in moderately-managed landscapes should be included in conservation initiatives to maintain landscape heterogeneity, species diversity, and ecosystem services.

40 CFR 141.81 - Applicability of corrosion control treatment steps to small, medium-size and large water systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... treatment steps to small, medium-size and large water systems. 141.81 Section 141.81 Protection of... to small, medium-size and large water systems. (a) Systems shall complete the applicable corrosion...) or (b)(3) of this section. (2) A small system (serving ≤3300 persons) and a medium-size system...

40 CFR 141.81 - Applicability of corrosion control treatment steps to small, medium-size and large water systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... treatment steps to small, medium-size and large water systems. 141.81 Section 141.81 Protection of... to small, medium-size and large water systems. (a) Systems shall complete the applicable corrosion...) or (b)(3) of this section. (2) A small system (serving ≤3300 persons) and a medium-size system...

40 CFR 141.81 - Applicability of corrosion control treatment steps to small, medium-size and large water systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... treatment steps to small, medium-size and large water systems. 141.81 Section 141.81 Protection of... to small, medium-size and large water systems. (a) Systems shall complete the applicable corrosion...) or (b)(3) of this section. (2) A small system (serving ≤3300 persons) and a medium-size system...

40 CFR 141.81 - Applicability of corrosion control treatment steps to small, medium-size and large water systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... treatment steps to small, medium-size and large water systems. 141.81 Section 141.81 Protection of... to small, medium-size and large water systems. (a) Systems shall complete the applicable corrosion...) or (b)(3) of this section. (2) A small system (serving ≤3300 persons) and a medium-size system...

Selection against small males in utero: a test of the Wells hypothesis

PubMed Central

Catalano, R.; Goodman, J.; Margerison-Zilko, C.E.; Saxton, K.B.; Anderson, E.; Epstein, M.

2012-01-01

BACKGROUND The argument that women in stressful environments spontaneously abort their least fit fetuses enjoys wide dissemination despite the fact that several of its most intuitive predictions remain untested. The literature includes no tests, for example, of the hypothesis that these mechanisms select against small for gestational age (SGA) males. METHODS We apply time-series modeling to 4.9 million California male term births to test the hypothesis that the rate of SGA infants in 1096 weekly birth cohorts varies inversely with labor market contraction, a known stressor of contemporary populations. RESULTS We find support for the hypothesis that small size becomes less frequent among term male infants when the labor market contracts. CONCLUSIONS Our findings contribute to the evidence supporting selection in utero. They also suggest that research into the association between maternal stress and adverse birth outcomes should acknowledge the possibility that fetal loss may affect findings and their interpretation. Strengths of our analyses include the large number and size of our birth cohorts and our control for autocorrelation. Weaknesses include that we, like nearly all researchers in the field, have no direct measure of fetal loss. PMID:22298840

77 FR 13329 - Information Collection; Small Business Size Representation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

... Collection 9000- 0163, Small Business Size Representation, by any of the following methods: Regulations.gov... ADMINISTRATION [OMB Control No. 9000-0163; Docket 2011-0076; Sequence 6] Information Collection; Small Business... previously approved information collection requirement regarding small business size representation. DATES...

Counting particles emitted by stratospheric aircraft and measuring size of particles emitted by stratospheric aircraft

NASA Technical Reports Server (NTRS)

Wilson, James Charles

1994-01-01

The ER-2 condensation nuclei counter (CNC) has been modified to reduce the diffusive losses of particles within the instrument. These changes have been successful in improving the counting efficiency of small particles at low pressures. Two techniques for measuring the size distributions of particles with diameters less than 0.17 micrometers have been evaluated. Both of these methods, the differential mobility analyzer (DMA) and the diffusion battery, have fundamental problems that limit their usefulness for stratospheric applications. We cannot recommend either for this application. Newly developed, alternative methods for measuring small particles include inertial separation with a low-loss critical orifice and thin-plate impactor device. This technique is now used to collect particles in the multisample aerosol collector housed in the ER-2 CNC-2, and shows some promise for particle size measurements when coupled with a CNC as a counting device. The modified focused-cavity aerosol spectrometer (FCAS) can determine the size distribution of particles with ambient diameters as small as about 0.07 micrometers. Data from this instrument indicates the presence of a nuclei mode when CNC-2 indicates high concentrations of particles, but cannot resolve important parameters of the distribution.

COLLISIONAL EVOLUTION OF ULTRA-WIDE TRANS-NEPTUNIAN BINARIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker, Alex H.; Kavelaars, J. J., E-mail: alexhp@uvic.ca

2012-01-10

The widely separated, near-equal mass binaries hosted by the cold classical Kuiper Belt are delicately bound and subject to disruption by many perturbing processes. We use analytical arguments and numerical simulations to determine their collisional lifetimes given various impactor size distributions and include the effects of mass loss and multiple impacts over the lifetime of each system. These collisional lifetimes constrain the population of small (R {approx}> 1 km) objects currently residing in the Kuiper Belt and confirm that the size distribution slope at small size cannot be excessively steep-likely q {approx}< 3.5. We track mutual semimajor axis, inclination, andmore » eccentricity evolution through our simulations and show that it is unlikely that the wide binary population represents an evolved tail of the primordially tight binary population. We find that if the wide binaries are a collisionally eroded population, their primordial mutual orbit planes must have preferred to lie in the plane of the solar system. Finally, we find that current limits on the size distribution at small radii remain high enough that the prospect of detecting dust-producing collisions in real time in the Kuiper Belt with future optical surveys is feasible.« less

Bayesian evaluation of effect size after replicating an original study

PubMed Central

van Aert, Robbie C. M.; van Assen, Marcel A. L. M.

2017-01-01

The vast majority of published results in the literature is statistically significant, which raises concerns about their reliability. The Reproducibility Project Psychology (RPP) and Experimental Economics Replication Project (EE-RP) both replicated a large number of published studies in psychology and economics. The original study and replication were statistically significant in 36.1% in RPP and 68.8% in EE-RP suggesting many null effects among the replicated studies. However, evidence in favor of the null hypothesis cannot be examined with null hypothesis significance testing. We developed a Bayesian meta-analysis method called snapshot hybrid that is easy to use and understand and quantifies the amount of evidence in favor of a zero, small, medium and large effect. The method computes posterior model probabilities for a zero, small, medium, and large effect and adjusts for publication bias by taking into account that the original study is statistically significant. We first analytically approximate the methods performance, and demonstrate the necessity to control for the original study’s significance to enable the accumulation of evidence for a true zero effect. Then we applied the method to the data of RPP and EE-RP, showing that the underlying effect sizes of the included studies in EE-RP are generally larger than in RPP, but that the sample sizes of especially the included studies in RPP are often too small to draw definite conclusions about the true effect size. We also illustrate how snapshot hybrid can be used to determine the required sample size of the replication akin to power analysis in null hypothesis significance testing and present an easy to use web application (https://rvanaert.shinyapps.io/snapshot/) and R code for applying the method. PMID:28388646

Prevalence of advanced adenomas in small and diminutive colon polyps using direct measurement of size.

PubMed

Tsai, Franklin C; Strum, Williamson B

2011-08-01

Most studies reporting polyp size use visual estimates. Determining the prevalence of advanced histology based on direct measurement of polyp size may help guide the management of polyps found at optical colonoscopy (OC) and CT colonography (CTC). We designed a large, prospective study to assess the prevalence of advanced adenomas based on direct measurement of polyp size by a certified pathologists' assistant as reported in the pathology report. Patients between 40 and 89 years of age who presented for screening colonoscopy were included in our study. Advanced adenomas were defined as ≥10 mm or ≥25% villous features, high grade dysplasia or cancer. Polyps were divided by size into three groups: diminutive (≤5 mm), small (6-9 mm) and large (≥10 mm). If more than one adenoma was present, the most advanced was used for analysis. We evaluated 6,905 consecutive patients referred for colonoscopy between January 2005 and December 2006. Of the 4,967 who met the inclusion criteria, the mean age was 58.8 and consisted of 59% women. Overall, 930 (18.7%) had an adenoma; 248 (5%) were advanced adenomas including 8 (0.16%) cancers. Of 89 polyps≥10 mm, 76 (85%) had advanced histology; of 247 polyps 6-9 mm, 67 (27%) were advanced; of 1,025 polyps ≤5 mm, 105 (10%) were advanced. Thus, 172 of 248 (69%) patients with advanced adenomas had small or diminutive adenomas. Our data indicate the majority (69%) of advanced adenomas are <10 mm. Even among polyps≤5 mm, there was an appreciable prevalence of advanced adenomas (10%). These findings may help guide the management of sub-centimeter colon polyps found by OC or CTC.

Glans size is an independent risk factor for urethroplasty complications after hypospadias repair.

PubMed

Bush, Nicol C; Villanueva, Carlos; Snodgrass, Warren

2015-12-01

We hypothesized small glans size could increase urethroplasty complications (UC) following hypospadias repair. To test this, we measured glans width at its widest point in consecutive patients with hypospadias, and following a protocol for surgical decision-making, we then assessed post-operative UC using pre-determined definitions. We now report analysis of glans size as a potential additional independent risk factor for UC after hypospadias repair. Consecutive prepubertal patients undergoing hypospadias repair (2009-2013) had maximum glans width measured using calipers (Fig. 1). There were no differences in surgical technique for urethroplasty or glansplasty in this series based on the measured size of the glans. Multivariate logistic regression analyzed UC (fistula, glans dehiscence, diverticulum, stricture and/or meatal stenosis) based on glans size while adjusting for patient age, meatus (distal or midshaft/proximal), type of repair (TIP, inlay, 2-stage), surgeon, and primary or reoperative repair. Glans size was analyzed as both a continuous and dichotomous variable, with small glans defined as <14 mm. Mean glans size was 15 mm (10-27 mm) in 490 boys (mean 1.5 years) undergoing 432 primary repairs (380d/19mid/33prox), and 58 reoperations (28d/7mid/23prox). Increasing age between 3 months and 10 years did not correlate with increasing glans size (R = 0.01, p = 0.18). 17% had small glans <14 mm. UC occurred in 61 (13%) primary TIP, 2-stage, and reoperative repairs, including 20/81 (25%) patients with small glans <14 mm, versus 41/409 (10%) in patients with glans width ≥14 mm (p = 0.0003). On multivariate analysis, small glans size (OR 3.5, 95% CI 1.8-6.8), reoperations (OR 3.0, 95% CI 1.4-6.5) and mid/proximal meatus (OR 3.1, 95% CI 1.6-6.2) were independent risk factors for UC. Surgeon, repair type, and patient age did not impact risk for UC. Analysis with glans size as a continuous variable demonstrated each 1 mm increase in size decreased odds of UC (OR 0.8, 95% CI 0.7-0.9). Our analysis of prospectively-collected data from a standardized management protocol in 490 consecutive boys undergoing hypospadias repair adds small glans size, defined as width <14 mm, to proximal meatal location and reoperation as an independent risk factor for UC. Best means to modify this factor remain to be determined. Our data suggest that others analyzing potential risks for hypospadias UC should similarly measure and report glans width. Copyright © 2015 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

Nonplantigrade Foot Posture: A Constraint on Dinosaur Body Size

PubMed Central

Kubo, Tai; Kubo, Mugino O.

2016-01-01

Dinosaurs had functionally digitigrade or sub-unguligrade foot postures. With their immediate ancestors, dinosaurs were the only terrestrial nonplantigrades during the Mesozoic. Extant terrestrial mammals have different optimal body sizes according to their foot posture (plantigrade, digitigrade, and unguligrade), yet the relationship of nonplantigrade foot posture with dinosaur body size has never been investigated, even though the body size of dinosaurs has been studied intensively. According to a large dataset presented in this study, the body sizes of all nonplantigrades (including nonvolant dinosaurs, nonvolant terrestrial birds, extant mammals, and extinct Nearctic mammals) are above 500 g, except for macroscelid mammals (i.e., elephant shrew), a few alvarezsauroid dinosaurs, and nondinosaur ornithodirans (i.e., the immediate ancestors of dinosaurs). When nonplantigrade tetrapods evolved from plantigrade ancestors, lineages with nonplantigrade foot posture exhibited a steady increase in body size following Cope’s rule. In contrast, contemporaneous plantigrade lineages exhibited no trend in body size evolution and were largely constrained to small body sizes. This evolutionary pattern of body size specific to foot posture occurred repeatedly during both the Mesozoic and the Cenozoic eras. Although disturbed by the end-Cretaceous extinction, species of mid to large body size have predominantly been nonplantigrade animals from the Jurassic until the present; conversely, species with small body size have been exclusively composed of plantigrades in the nonvolant terrestrial tetrapod fauna. PMID:26790003

Nonplantigrade Foot Posture: A Constraint on Dinosaur Body Size.

PubMed

Kubo, Tai; Kubo, Mugino O

2016-01-01

Dinosaurs had functionally digitigrade or sub-unguligrade foot postures. With their immediate ancestors, dinosaurs were the only terrestrial nonplantigrades during the Mesozoic. Extant terrestrial mammals have different optimal body sizes according to their foot posture (plantigrade, digitigrade, and unguligrade), yet the relationship of nonplantigrade foot posture with dinosaur body size has never been investigated, even though the body size of dinosaurs has been studied intensively. According to a large dataset presented in this study, the body sizes of all nonplantigrades (including nonvolant dinosaurs, nonvolant terrestrial birds, extant mammals, and extinct Nearctic mammals) are above 500 g, except for macroscelid mammals (i.e., elephant shrew), a few alvarezsauroid dinosaurs, and nondinosaur ornithodirans (i.e., the immediate ancestors of dinosaurs). When nonplantigrade tetrapods evolved from plantigrade ancestors, lineages with nonplantigrade foot posture exhibited a steady increase in body size following Cope's rule. In contrast, contemporaneous plantigrade lineages exhibited no trend in body size evolution and were largely constrained to small body sizes. This evolutionary pattern of body size specific to foot posture occurred repeatedly during both the Mesozoic and the Cenozoic eras. Although disturbed by the end-Cretaceous extinction, species of mid to large body size have predominantly been nonplantigrade animals from the Jurassic until the present; conversely, species with small body size have been exclusively composed of plantigrades in the nonvolant terrestrial tetrapod fauna.

Volatiles in interplanetary dust particles: A comparison with CI and CM chondrites

NASA Technical Reports Server (NTRS)

Bustin, Roberta

1992-01-01

In an effort to classify and determine the origin of interplanetary dust particles (IDPs), 14 of these particles were studied using a laser microprobe/mass spectrometer. The mass spectra for these particles varied dramatically. Some particles released hydroxide or water which probably originated in hydroxide-bearing minerals or hydrates. Others produced spectra which included a number of hydrocarbons and resembled meteorite spectra. However, none of the individual IDPs gave spectra which could be matched identically with a particular meteorite type such as a CI or CM carbonaceous chondrite. We believe this was due to the fact that 10-20 micron size IDPs are too small to be representative of the parent body. To verify that the diversity was due primarily to the small particle sizes, small grains of approximately the same size range as the IDPs were obtained from two primitive meteorites, Murchison and Orgueil, and these small meteorite particles were treated exactly like the IDPs. Considerable diversity was observed among individual grains, but a composite spectrum of all the grains from one meteorite closely resembled the spectrum obtained from a much larger sample of that meteorite. A composite spectrum of the 14 IDPs also resembled the spectra of the CM and CI meteorites, pointing to a possible link between IDPs and carbonaceous chondrites. This also illustrates that despite the inherent diversity in particles as small as 10-20 micron, conclusions can be drawn about the possible origin and overall composition of such particles by looking not only at results from individual particles but also by including many particles in a study and basing conclusions on some kind of composite data.

A case report of CIC-rearranged undifferentiated small round cell sarcoma in the cerebrum.

PubMed

Ito, Mayumi; Ishikawa, Misawo; Kitajima, Masateru; Narita, Jun; Hattori, Shinya; Endo, Otone; Goto, Keisuke

2016-10-01

CIC-rearranged undifferentiated small round cell sarcoma (CIC-rearranged USRCS) is a recently established type of Ewing-like small round cell sarcomas, characterized by CIC gene rearrangement, most commonly CIC-DUX4 fusion. This report presents the second case of CIC-rearranged USRCS arising primarily in the cerebrum. A 64-year-old otherwise healthy woman presented with a 1 × 1 cm sized hemorrhagic subcortical tumor in the left temporo-parietal lobe. The tumor repeatedly recurred, and the patient underwent three surgeries, chemotherapy with doxorubicin and ifosfamide, and radiotherapy, as well as gamma knife surgery. Systemic examination revealed no other extracranial masses. Imprint cytology revealed small to moderate-sized round-to-ovoid tumor cells with mild pleomorphism and variations in size and shape. The nuclei contained finely granular chromatin, and some had easily-recognizable nucleoli. The tumor exhibited a mainly cytoplasmic pattern of CD99 immunostaining, rather than a diffuse membranous pattern. The tumor also exhibited diffuse positivity for calretinin and p16, as well as partial positivity for WT1 (nuclear and cytoplasmic staining pattern) and D2-40. FISH assessment showed CIC split signals. In conclusion, CIC-rearranged USRCSs can occur primarily in the cerebrum. It would be impossible to diagnose them through cytology alone, but cytology would be useful to rule out other small round cell brain tumors including gliomas, lymphomas, carcinomas, and germinoma. Immunohistochemical analysis including tests for CD99, calretinin, and WT1 would help to suggest CIC-rearranged USRCSs and distinguish them from Ewing sarcomas. Additionally, immunohistochemistry for p16 might be useful in the diagnosis. Diagn. Cytopathol. 2016;44:828-832. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

77 FR 58739 - Small Business Size Standards: Educational Services

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... programs, SBA establishes small business size definitions (referred to as size standards) for private... programs effectively, SBA establishes distinct definitions to determine which businesses are deemed small... businesses definitions (15 U.S.C. 632(a)). The Act also requires that small business definitions vary to...

77 FR 10943 - Small Business Size Standards: Transportation and Warehousing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... assistance programs, SBA establishes small business size definitions (referred to as size standards) for... business concern * * *'' Sec. 3(a)(2)(C)(ii)(II) [emphasis added]. Third, SBA's existing definitions of... establishes distinct definitions to determine which businesses are deemed small businesses. The Small Business...

Simplified HCC-ART score for highly sensitive detection of small-sized and early-stage hepatocellular carcinoma in the widely used Okuda, CLIP, and BCLC staging systems.

PubMed

Attallah, Abdelfattah M; Omran, Mohamed M; Attallah, Ahmed A; Abdelrazek, Mohamed A; Farid, Khaled; El-Dosoky, Ibrahim

2017-04-01

Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC. Different HCC-ART cutoffs were set for the detection of different tumor sizes. The HCC-ART (AUC = 0.871, 70% sensitivity, 97% specificity) and the simplified HCC-ART (AUC = 0.934, 82% sensitivity, 100% specificity) were found to have high predictive power when attempting to separate cirrhotic patients from those with small-sized HCC. The simplified HCC-ART score was superior to AFP for determining stages according to the early Okuda (0.950 AUC, 84% sensitivity, 99% specificity), CLIP (0.945 AUC, 84% sensitivity, 99% specificity), and BCLC (1.000 AUC, 100% sensitivity, 99% specificity) staging systems. The simplified HCC-ART score was more strongly correlated than AFP and other staging systems with HCC tumor size (P < 0.0001; r = 0.8). The HCC-ART is superior to AFP for diagnosing early-stage HCC. Due to its advantages of minimal variability and a wide continuous scale for assessing HCC severity, the simplified HCC-ART has the potential to be more widely used than the original HCC-ART.

Characterization of Carbon Onion Nanomaterials for Environmental Remediation

EPA Science Inventory

The unique properties of carbonaceous nanomaterials, including small particle size, high surface area, and manipulatable surface chemistry, provide high potential for their application to environmental remediation. While research has devoted to develop nanotechnology for environm...

Large-Scale Hybrid Motor Testing. Chapter 10

NASA Technical Reports Server (NTRS)

Story, George

2006-01-01

Hybrid rocket motors can be successfully demonstrated at a small scale virtually anywhere. There have been many suitcase sized portable test stands assembled for demonstration of hybrids. They show the safety of hybrid rockets to the audiences. These small show motors and small laboratory scale motors can give comparative burn rate data for development of different fuel/oxidizer combinations, however questions that are always asked when hybrids are mentioned for large scale applications are - how do they scale and has it been shown in a large motor? To answer those questions, large scale motor testing is required to verify the hybrid motor at its true size. The necessity to conduct large-scale hybrid rocket motor tests to validate the burn rate from the small motors to application size has been documented in several place^'^^.^. Comparison of small scale hybrid data to that of larger scale data indicates that the fuel burn rate goes down with increasing port size, even with the same oxidizer flux. This trend holds for conventional hybrid motors with forward oxidizer injection and HTPB based fuels. While the reason this is occurring would make a great paper or study or thesis, it is not thoroughly understood at this time. Potential causes include the fact that since hybrid combustion is boundary layer driven, the larger port sizes reduce the interaction (radiation, mixing and heat transfer) from the core region of the port. This chapter focuses on some of the large, prototype sized testing of hybrid motors. The largest motors tested have been AMROC s 250K-lbf thrust motor at Edwards Air Force Base and the Hybrid Propulsion Demonstration Program s 250K-lbf thrust motor at Stennis Space Center. Numerous smaller tests were performed to support the burn rate, stability and scaling concepts that went into the development of those large motors.

Casein polymorphism heterogeneity influences casein micelle size in milk of individual cows.

PubMed

Day, L; Williams, R P W; Otter, D; Augustin, M A

2015-06-01

Milk samples from individual cows producing small (148-155 nm) or large (177-222 nm) casein micelles were selected to investigate the relationship between the individual casein proteins, specifically κ- and β-casein phenotypes, and casein micelle size. Only κ-casein AA and β-casein A1A1, A1A2 and A2A2 phenotypes were found in the large casein micelle group. Among the small micelle group, both κ-casein and β-casein phenotypes were more diverse. κ-Casein AB was the dominant phenotype, and 3 combinations (AA, AB, and BB) were present in the small casein micelle group. A considerable mix of β-casein phenotypes was found, including B and I variants, which were only found in the small casein micelle group. The relative amount of κ-casein to total casein was significantly higher in the small micelle group, and the nonglycosylated and glycosylated κ-casein contents were higher in the milks with small casein micelles (primarily with κ-casein AB and BB variants) compared with the large micelle group. The ratio of glycosylated to nonglycosylated κ-casein was higher in the milks with small casein micelles compared with the milks with large casein micelles. This suggests that although the amount of κ-casein (both glycosylated and nonglycosylated) is associated with micelle size, an increased proportion of glycosylated κ-casein could be a more important and favorable factor for small micelle size. This suggests that the increased spatial requirement due to addition of the glycosyl group with increasing extent of glycosylation of κ-casein is one mechanism that controls casein micelle assembly and growth. In addition, increased electrostatic repulsion due to the sialyl residues on the glycosyl group could be a contributory factor. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Correlation Between Echinoidea Size and Threat Level

NASA Astrophysics Data System (ADS)

Bakshi, S.; Lee, A.; Heim, N.; Payne, J.

2017-12-01

Echinoidea (or sea urchins), are small, spiny, globular, animals that populate the seafloors of nearly the entire planet. Echinoidea have existed on Earth since the Ordovician period, and from their archaic origin there is much to be learned about the relationship between Echinoidea body size and how it affects the survivability of the individual. The goal of this project is to determine how Echinoidea dimensions such as body volume, area, and length compare across extinct and extant species by plotting Echinoidea data in R. We will use stratigraphic data as a source to find which species of sea urchin from our data is extinct. We will then create three sets of three histograms of the size data for each type of measurement. One set will include histograms for sea urchin length, area, and volume. The other set will include histograms for extinct sea urchin length, area, and volume. The last set will include histograms for extant sea urchin length, area, and volume. Our data showed that extant sea urchins had a larger size, and extinct sea urchins were smaller. Our length data showed that the average length of all sea urchins were 54.95791 mm, the average length of extinct sea urchins were 51.0337 mm, and the average length of extant sea urchins were 66.12774 mm. There is a generally increasing trend of size over time, except for a small outlier about 350 million years ago, where echinoderm extinction selected towards larger species and biovolume was abnormally high. Our data also showed that over the past 200 million years, echinoderm extinction selectivity drove slightly smaller sea urchins towards extinction, further supporting the idea that a larger size was and still is advantageous for echinoderms.

77 FR 39385 - Receipts-Based, Small Business Size Standard

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... Business Size Standard AGENCY: Nuclear Regulatory Commission. ACTION: Direct final rule. SUMMARY: The U.S.... The NRC is increasing its receipts-based, small business size standard from $6.5 million to $7 million to conform to the standard set by the Small Business Administration (SBA). This size standard...

EXPLORING THE ROLE OF SUB-MICRON-SIZED DUST GRAINS IN THE ATMOSPHERES OF RED L0–L6 DWARFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hiranaka, Kay; Cruz, Kelle L.; Baldassare, Vivienne F.

We examine the hypothesis that the red near-infrared colors of some L dwarfs could be explained by a “dust haze” of small particles in their upper atmospheres. This dust haze would exist in conjunction with the clouds found in dwarfs with more typical colors. We developed a model that uses Mie theory and the Hansen particle size distributions to reproduce the extinction due to the proposed dust haze. We apply our method to 23 young L dwarfs and 23 red field L dwarfs. We constrain the properties of the dust haze including particle size distribution and column density using Markovmore » Chain Monte Carlo methods. We find that sub-micron-range silicate grains reproduce the observed reddening. Current brown dwarf atmosphere models include large-grain (1–100 μ m) dust clouds but not sub-micron dust grains. Our results provide a strong proof of concept and motivate a combination of large and small dust grains in brown dwarf atmosphere models.« less

13 CFR 121.411 - What are the size procedures for SBA's Section 8(d) Subcontracting Program?

Code of Federal Regulations, 2013 CFR

2013-01-01

... SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards... maintaining a small business source list. Even though a concern is on a small business source list, it must still qualify and self-certify as a small business at the time it submits its offer as a section 8(d...

13 CFR 121.411 - What are the size procedures for SBA's Section 8(d) Subcontracting Program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards... maintaining a small business source list. Even though a concern is on a small business source list, it must still qualify and self-certify as a small business at the time it submits its offer as a section 8(d...

13 CFR 121.411 - What are the size procedures for SBA's Section 8(d) Subcontracting Program?

Code of Federal Regulations, 2012 CFR

2012-01-01

... SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards... maintaining a small business source list. Even though a concern is on a small business source list, it must still qualify and self-certify as a small business at the time it submits its offer as a section 8(d...

LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients

PubMed Central

Kotani, Kazuhiko; Tsuzaki, Kokoro; Taniguchi, Nobuyuki; Sakane, Naoki

2012-01-01

Objectives: Small dense low-density lipoprotein (sdLDL) which has a small LDL particle size with greater susceptibility to oxidation is regarded as a risk marker for cardiovascular disease. The diacron reactive oxygen metabolites (d-ROMs) test has recently been introduced as an oxidative stress-related marker in the clinic. The aim of the present study was to investigate the correlation between the mean LDL particle size and the oxidative stress status as evaluated by the d-ROMs in dyslipidemic patients. Methods: The study included 278 dyslipidemic patients (121 male and 157 female, mean age, 60 years). Clinical data including the conventional atherosclerotic risk factors in addition to the mean LDL particle size measured with the gel electrophoresis and the d-ROMs were collected. Results: Male patients had a significantly smaller mean LDL particle size than females (262.2 ± 7.5 [SD] vs. 264.3 ± 6.7 Å, P<0.05), while female patients had a significantly higher d-ROMs level than males (318 ± 68 vs. 350 ± 72 U. Carr., P<0.01). A multiple regression analysis revealed that there was an independent, significant, and inverse correlation between the mean LDL particle size and the d-ROMs (β=−0.19, P<0.05). Conclusions: These findings of the co-existence of both markers suggest that sdLDL and oxidative stress can be cooperative in atherogenesis, possibly leading to the incidence of CVD, in dyslipidemic patients. PMID:22448308

Detection of small-size solder ball defects through heat conduction analysis

NASA Astrophysics Data System (ADS)

Zhou, Xiuyun; Chen, Yaqiu; Lu, Xiaochuan

2018-02-01

Aiming to solve the defect detection problem of a small-size solder ball in the high density chip, heat conduction analysis based on eddy current pulsed thermography is put forward to differentiate various defects. With establishing the 3D finite element model about induction heating, defects such as cracks and void can be distinguished by temperature difference resulting from heat conduction. Furthermore, the experiment of 0.4 mm-diameter solder balls with different defects is carried out to prove that crack and void solder can be distinguished. Three kinds of crack length on a gull-wing pin are selected, including 0.24 mm, 1.2 mm, and 2.16 mm, to verify that the small defect can be discriminated. Both the simulation study and experiment result show that the heat conduction analysis method is reliable and convenient.

48 CFR 19.302 - Protesting a small business representation or rerepresentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Determination of Small Business Status for Small Business Programs 19.302 Protesting a small business representation or rerepresentation. (a)(1) The Small Business Administration (SBA) regulations on small business size and size...

40 CFR 428.50 - Applicability; description of the small-sized general molded, extruded, and fabricated rubber...

Code of Federal Regulations, 2010 CFR

2010-07-01

... RUBBER MANUFACTURING POINT SOURCE CATEGORY Small-Sized General Molded, Extruded, and Fabricated Rubber..., foam rubber backing, rubber cement-dipped goods, and retreaded tires by small-sized plants...

The electrical performance of Ag Zn batteries for the Venus multi-probe mission

NASA Technical Reports Server (NTRS)

Palandati, C.

1975-01-01

An evaluation of 5 Ah and 21 Ah Silver-Zinc batteries was made to determine their suitability to meet the energy storage requirements of the bus vehicle, 3 small probes and large probe for the Venus multi-probe mission. The evaluation included a 4 Ah battery for the small probe, a 21 Ah battery for the large probe, one battery of each size for the bus vehicle power, a periodic cycling test on each size battery and a wet stand test of charged and discharged cells of both cell designs. The study on the probe batteries and bus vehicle batteries included both electrical and thermal simulation for the entire mission. The effects on silver migration and zinc penetration of the cellophane separators caused by the various test parameters were determined by visual and X-ray fluorescence analysis. The 5 Ah batteries supported the power requirements for the bus vehicle and small probe. The 21 Ah large probe battery supplied the required mission power. Both probe batteries delivered in excess of 132 percent of rated capacity at the completion of the mission simulation.

Size- and temperature-dependent Hamaker constants for heterogeneous systems of interacting nanoparticles

NASA Astrophysics Data System (ADS)

Pinchuk, P.; Pinchuk, A. O.

2016-09-01

Hamaker-Lifshitz constants are used to calculate van der Waals interaction forces between small particles in solution. Typically, these constants are size-independent and material specific. According to the Lifshitz theory, the Hamaker-Lifshitz constants can be calculated by taking integrals that include the dielectric permittivity, as a function of frequency, of the interacting particles and the medium around particles. The dielectric permittivity of interacting metal nanoparticles can be calculated using the free-electron Drude model for metals. For bulk metals, the Drude model does is size independent. However, the conducting electrons in small metal nanoparticles exhibit surface scattering, which changes the complex dielectric permittivity function. Additionally, the Drude model can be modified to include temperature dependence. That is, an increase in temperature leads to thermal volume expansion and increased phonon population, which affect the scattering rate of the electrons and the plasma frequency. Both of these terms contribute significantly to the Drude model for the dielectric permittivity of the particles. In this work, we show theoretically that scattering of the free conducting electrons inside noble metal nanoparticles with the size of 1 - 50 nm leads to size-dependent dielectric permittivity and Hamaker-Lifshitz constants. In addition, we calculate numerically the Hamaker-Lifshitz constants for a variety of temperatures. The results of the study might be of interest for understanding colloidal stability of metal nanoparticles.

[Characteristics of particle size structure of plankton community in turbidity zone of near-shore waters, Liaoning Province of Northeast China].

PubMed

Song, Lun; Wang, Nian-bin; Song, Yong-Gang; Li, Nan

2013-04-01

Estuary and nearshore waters have complicated environment, where plankton community has a frequent feedback regulation and a very unstable particle size structure. In this paper, an investigation was made on the particle size structure of plankton in the turbidity zone of nearshore and port area waters in Liaoning Province of Northeast China. In the waters with high concentration inorganic nitrogen, phytoplankton biomass was mainly of small particle sizes, with the equivalent sphere diameter (ESD) being primarily 20-100 micro m, while in low nutrient waters, the phytoplankton biomass was mainly of larger size particles, with the ESD>100 micro m, indicating that the phytoplankton feedback regulation caused the phytoplankton community to be comprised of small sized organisms as part of the biological responses to high concentration suspended solids, which reduced the individual number of larger organisms such as Coscinodiscus. sp. and other species, and in turn, directly affected the fisheries resources, including a variety of fish and shrimp larvae fed on phytoplankton. A normalized biomass size spectrum with the characteristics of nearshore shallow aquatic oceanic ecosystems exhibiting eutrophication was constructed. The spectrum slope indicated that the plankton community biomass would gradually increase in size. The feasibility of using dinoflagellates and cladocerans as the bio-indicators for eutrophication was discussed.

Disturbance size and severity covary in small and mid-size wind disturbances in Pennsylvania northern hardwoods forests

Treesearch

Chris J. Peterson; Lisa M. Krueger; Alejandro A. Royo; Scott Stark; Walter P. Carson

2013-01-01

Do large disturbances differ from small ones in characteristics other than size? The importance of disturbances in forest dynamics is unquestioned, and the size of the disturbed area (size of gap) is the most common way of differentiating disturbances. But few studies have examined other disturbance characteristics to see if small and large disturbances are different....

Determination by Small-angle X-ray Scattering of Pore Size Distribution in Nanoporous Track-etched Polycarbonate Membranes

NASA Astrophysics Data System (ADS)

Jonas, A. M.; Legras, R.; Ferain, E.

1998-03-01

Nanoporous track-etched membranes with narrow pore size distributions and average pore size diameters tunable from 100 to 1000 Åare produced by the chemical etching of latent tracks in polymer films after irradiation by a beam of accelerated heavy ions. Nanoporous membranes are used for highly demanding filtration purposes, or as templates to obtain metallic or polymeric nanowires (L. Piraux et al., Nucl. Instr. Meth. Phys. Res. 1997, B131, 357). Such applications call for developments in nanopore size characterization techniques. In this respect, we report on the characterization by small-angle X-ray scattering (SAXS) of nanopore size distribution (nPSD) in polycarbonate track-etched membranes. The obtention of nPSD requires inverting an ill-conditioned inhomogeneous equation. We present different numerical routes to overcome the amplification of experimental errors in the resulting solutions, including a regularization technique allowing to obtain the nPSD without a priori knowledge of its shape. The effect of deviations from cylindrical pore shape on the resulting distributions are analyzed. Finally, SAXS results are compared to results obtained by electron microscopy and conductometry.

Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy

NASA Astrophysics Data System (ADS)

Kobayashi, Hisataka; Choyke, Peter L.

2016-06-01

To date, the delivery of nano-sized therapeutic agents to cancers largely relies on enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. However, nano-sized agents delivered in this way have demonstrated limited success in oncology due to the relatively small magnitude of the EPR effect. For achieving superior delivery of nano-sized agents, super-enhanced permeability and retention (SUPR) effects are needed. Near infrared photo-immunotherapy (NIR-PIT) is a recently reported therapy that treats tumors with light therapy and subsequently causes an increase in nano-drug delivery up to 24-fold compared with untreated tumors in which only the EPR effect is present. SUPR effects could enhance delivery into tumor beds of a wide variety of nano-sized agents including particles, antibodies, and protein binding small molecular agents. Therefore, taking advantage of the SUPR effects after NIR-PIT may be a promising avenue to utilize a wide variety of nano-drugs in a highly effective manner.

75 FR 68325 - Government Programs to Assist Businesses Protect Their Intellectual Property Rights (IPR) in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... of U.S. businesses, including Small- and Medium-Sized Enterprises (SMEs), in foreign markets. As... rights in foreign markets in particular. 2. Identify specific challenges businesses, including SMEs, face..., patents, trade secrets) present the most challenges to SMEs? Should U.S. government programs focus on...

77 FR 56253 - Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-12

... 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation... 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is..., Rechargeable Lithium Battery and Battery Systems--Small and Medium Size. DATES: The meeting will be held...

77 FR 66084 - Tenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-01

... 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation... 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is..., Rechargeable Lithium Battery and Battery Systems--Small and Medium Size. DATES: The meeting will be held...

Nonstandard convergence to jamming in random sequential adsorption: The case of patterned one-dimensional substrates

NASA Astrophysics Data System (ADS)

Verma, Arjun; Privman, Vladimir

2018-02-01

We study approach to the large-time jammed state of the deposited particles in the model of random sequential adsorption. The convergence laws are usually derived from the argument of Pomeau which includes the assumption of the dominance, at large enough times, of small landing regions into each of which only a single particle can be deposited without overlapping earlier deposited particles and which, after a certain time are no longer created by depositions in larger gaps. The second assumption has been that the size distribution of gaps open for particle-center landing in this large-time small-gaps regime is finite in the limit of zero gap size. We report numerical Monte Carlo studies of a recently introduced model of random sequential adsorption on patterned one-dimensional substrates that suggest that the second assumption must be generalized. We argue that a region exists in the parameter space of the studied model in which the gap-size distribution in the Pomeau large-time regime actually linearly vanishes at zero gap sizes. In another region, the distribution develops a threshold property, i.e., there are no small gaps below a certain gap size. We discuss the implications of these findings for new asymptotic power-law and exponential-modified-by-a-power-law convergences to jamming in irreversible one-dimensional deposition.

The digestive adaptation of flying vertebrates: high intestinal paracellular absorption compensates for smaller guts.

PubMed

Caviedes-Vidal, Enrique; McWhorter, Todd J; Lavin, Shana R; Chediack, Juan G; Tracy, Christopher R; Karasov, William H

2007-11-27

Anecdotal evidence suggests that birds have smaller intestines than mammals. In the present analysis, we show that small birds and bats have significantly shorter small intestines and less small intestine nominal (smooth bore tube) surface area than similarly sized nonflying mammals. The corresponding >50% reduction in intestinal volume and hence mass of digesta carried is advantageous because the energetic costs of flight increase with load carried. But, a central dilemma is how birds and bats satisfy relatively high energy needs with less absorptive surface area. Here, we further show that an enhanced paracellular pathway for intestinal absorption of water-soluble nutrients such as glucose and amino acids may compensate for reduced small intestines in volant vertebrates. The evidence is that l-rhamnose and other similarly sized, metabolically inert, nonactively transported monosaccharides are absorbed significantly more in small birds and bats than in nonflying mammals. To broaden our comparison and test the veracity of our finding we surveyed the literature for other similar studies of paracellular absorption. The patterns found in our focal species held up when we included other species surveyed in our analysis. Significantly greater amplification of digestive surface area by villi in small birds, also uncovered by our analysis, may provide one mechanistic explanation for the observation of higher paracellular absorption relative to nonflying mammals. It appears that reduced intestinal size and relatively enhanced intestinal paracellular absorption can be added to the suite of adaptations that have evolved in actively flying vertebrates.

Small sarcocysts can be a feature of experimental infections with Sarcocystis neurona merozoites.

PubMed

Marsh, Antoinette E; Chaney, Sarah B; Howe, Daniel K; Saville, William J; Reed, Stephen M

2017-10-15

Several reports indicate the presence of small tissue cysts associated with Sarcocystis neurona infections. Several failed attempts to develop tissue cysts in potential intermediate host using in vitro derived parasites originally isolated from horses with equine protozoal myeloencephalitis suggest that the experimental methods to achieve bradyzoites with those isolates was not possible. Those prior studies reported the lack of detectable sarcocysts based on histology and in vivo feeding trials. A recent report of successful production and detection of small sarcocysts triggered us to review archived tissues from earlier experimental infection studies. The retrospective review sought to determine if small sized sarcocysts were not detected due to their relatively smaller size and infrequency as compared to larger sized sarcocysts produced with other isolates in these experimental inoculation trials. Tissues from two prior in vivo inoculation studies, involving in vitro-produced parasites inoculated into laboratory-reared cats and raccoons, were re-examined by immunohistochemistry staining to more easily detect the tissue cysts. In the experimental cat study no small tissue cysts were seen, consistent with the original publication results. However, in the experimental raccoon study, one raccoon inoculated with an EPM-derived isolate, SN-UCD1, had small sarcocysts not reported in the original publication. This retrospective study suggests that much closer scrutiny of tissues, including the use of immunohistochemistry on tissue sections is required to detect the smaller S. neurona sarcocysts associated with the experimental inoculations of the isolates originally derived from horses with EPM. Published by Elsevier B.V.

Disaggregation of small, cohesive rubble pile asteroids due to YORP

NASA Astrophysics Data System (ADS)

Scheeres, D. J.

2018-04-01

The implication of small amounts of cohesion within relatively small rubble pile asteroids is investigated with regard to their evolution under the persistent presence of the YORP effect. We find that below a characteristic size, which is a function of cohesive strength, density and other properties, rubble pile asteroids can enter a "disaggregation phase" in which they are subject to repeated fissions after which the formation of a stabilizing binary system is not possible. Once this threshold is passed rubble pile asteroids may be disaggregated into their constituent components within a finite time span. These constituent components will have their own spin limits - albeit potentially at a much higher spin rate due to the greater strength of a monolithic body. The implications of this prediction are discussed and include modification of size distributions, prevalence of monolithic bodies among meteoroids and the lifetime of small rubble pile bodies in the solar system. The theory is then used to place constraints on the strength of binary asteroids characterized as a function of their type.

Vaccine Pipeline Has Grown During The Past Two Decades With More Early-Stage Trials From Small And Medium-Size Companies.

PubMed

Hwang, Thomas J; Kesselheim, Aaron S

2016-02-01

Many serious diseases lack safe and effective vaccines. Using a large commercial database, we examined trends in global vaccine research and development and found that the proportion of new vaccine candidates entering all stages of clinical development increased by 3-5 percentage points over the past two decades. Small and medium-size companies accounted for nearly twice as many new Phase I vaccine trials compared to large companies, but late-stage (Phase III) vaccine trials were dominated by large companies. There were no significant differences between vaccines and drugs in the probability of success in clinical trials or in profitability. Small and medium-size companies, including spin-outs from academic research centers, play an important role in innovative research and discovery. Our findings suggest that policy making targeted at smaller companies, such as prizes or opportunities for public-private partnerships, could support the development of new vaccines, particularly those targeting unmet medical needs and emerging public health threats. Project HOPE—The People-to-People Health Foundation, Inc.

A microfluidic platform for precision small-volume sample processing and its use to size separate biological particles with an acoustic microdevice [Precision size separation of biological particles in small-volume samples by an acoustic microfluidic system

DOE PAGES

Fong, Erika J.; Huang, Chao; Hamilton, Julie; ...

2015-11-23

Here, a major advantage of microfluidic devices is the ability to manipulate small sample volumes, thus reducing reagent waste and preserving precious sample. However, to achieve robust sample manipulation it is necessary to address device integration with the macroscale environment. To realize repeatable, sensitive particle separation with microfluidic devices, this protocol presents a complete automated and integrated microfluidic platform that enables precise processing of 0.15–1.5 ml samples using microfluidic devices. Important aspects of this system include modular device layout and robust fixtures resulting in reliable and flexible world to chip connections, and fully-automated fluid handling which accomplishes closed-loop sample collection,more » system cleaning and priming steps to ensure repeatable operation. Different microfluidic devices can be used interchangeably with this architecture. Here we incorporate an acoustofluidic device, detail its characterization, performance optimization, and demonstrate its use for size-separation of biological samples. By using real-time feedback during separation experiments, sample collection is optimized to conserve and concentrate sample. Although requiring the integration of multiple pieces of equipment, advantages of this architecture include the ability to process unknown samples with no additional system optimization, ease of device replacement, and precise, robust sample processing.« less

15 KW Small Turboelectric Power Generation System

DTIC Science & Technology

2006-08-18

1 hour per response, including the time for reviewing instnlctions, searching existing data sources, gathering and maintaining the data needed, and...pressure rise is consistent with data from the baseline compressor and a large body of published diffuser data . Table 1 LTS22 Compressor Preliminary... data on designs of 150 HP, 60 HP, and 5 HP engine size class, and in subsequent engine testing. The design methodology encompasses basic sizing

Probability of growth of small damage sites on the exit surface of fused silica optics.

PubMed

Negres, Raluca A; Abdulla, Ghaleb M; Cross, David A; Liao, Zhi M; Carr, Christopher W

2012-06-04

Growth of laser damage on fused silica optical components depends on several key parameters including laser fluence, wavelength, pulse duration, and site size. Here we investigate the growth behavior of small damage sites on the exit surface of SiO₂ optics under exposure to tightly controlled laser pulses. Results demonstrate that the onset of damage growth is not governed by a threshold, but is probabilistic in nature and depends both on the current size of a damage site and the laser fluence to which it is exposed. We also develop models for use in growth prediction. In addition, we show that laser exposure history also influences the behavior of individual sites.

Management of Anterior Skull Base Defect Depending on Its Size and Location

PubMed Central

Bernal-Sprekelsen, Manuel; Rioja, Elena; Enseñat, Joaquim; Enriquez, Karla; Viscovich, Liza; Agredo-Lemos, Freddy Enrique; Alobid, Isam

2014-01-01

Introduction. We present our experience in the reconstruction of these leaks depending on their size and location. Material and Methods. Fifty-four patients who underwent advanced skull base surgery (large defects, >20 mm) and 62 patients with CSF leaks of different origin (small, 2–10 mm, and midsize, 11–20 mm, defects) were included in the retrospective study. Large defects were reconstructed with a nasoseptal pedicled flap positioned on fat and fascia lata. In small and midsized leaks. Fascia lata in an underlay position was used for its reconstruction covered with mucoperiosteum of either the middle or the inferior turbinate. Results. The most frequent etiology for small and midsized defects was spontaneous (48.4%), followed by trauma (24.2%), iatrogenic (5%). The success rate after the first surgical reconstruction was 91% and 98% in large skull base defects and small/midsized, respectively. Rescue surgery achieved 100%. Conclusions. Endoscopic surgery for any type of skull base defect is the gold standard. The size of the defects does not seem to play a significant role in the success rate. Fascia lata and mucoperiosteum of the turbinate allow a two-layer reconstruction of small and midsized defects. For larger skull base defects, a combination of fat, fascia lata, and nasoseptal pedicled flaps provides a successful reconstruction. PMID:24895567

Reduced fecundity in small populations of the rare plant Gentianopsis ciliate (Gentianaceae)

USGS Publications Warehouse

Kery, M.; Matthies, D.

2004-01-01

Habitat destruction is the main cause for the biodiversity crisis. Surviving populations are often fragmented, i.e., small and isolated from each other. Reproduction of plants in small populations is often reduced, and this has been attributed to inbreeding depression, reduced attractiveness for pollinators, and reduced habitat quality in small populations. Here we present data on the effects of fragmentation on the rare, self-compatible perennial herb Gentianopsis ciliata (Gentianaceae), a species with very small and presumably well-dispersed seeds. We studied the relationship between population size, plant size, and the number of flowers produced in 63 populations from 1996-1998. In one of the years, leaf and flower size and the number of seeds produced per fruit was studied in a subset of 25 populations. Plant size, flower size, and the number of seeds per fruit and per plant increased with population size, whereas leaf length and the number of flowers per plant did not. The effects of population size on reproduction and on flower size remained significant if the effects were adjusted for differences in plant size, indicating that they could not be explained by differences in habitat quality. The strongly reduced reproduction in small populations may be due to pollination limitation, while the reduced flower size could indicate genetic effects.

Reduced fecundity in small populations of the rare plant Gentianopsis ciliate (Gentianaceae)

USGS Publications Warehouse

Robbins, C.S.

1983-01-01

Habitat destruction is the main cause for the biodiversity crisis. Surviving populations are often fragmented, i.e., small and isolated from each other. Reproduction of plants in small populations is often reduced, and this has been attributed to inbreeding depression, reduced attractiveness for pollinators, and reduced habitat quality in small populations. Here we present data on the effects of fragmentation on the rare, self-compatible perennial herb Gentianopsis ciliata (Gentianaceae), a species with very small and presumably well-dispersed seeds. We studied the relationship between population size, plant size, and the number of flowers produced in 63 populations from 1996-1998. In one of the years, leaf and flower size and the number of seeds produced per fruit was studied in a subset of 25 populations. Plant size, flower size, and the number of seeds per fruit and per plant increased with population size, whereas leaf length and the number of flowers per plant did not. The effects of population size on reproduction and on flower size remained significant if the effects were adjusted for differences in plant size, indicating that they could not be explained by differences in habitat quality. The strongly reduced reproduction in small populations may be due to pollination limitation, while the reduced flower size could indicate genetic effects.

13 CFR 121.903 - How may an agency use size standards for its programs that are different than those established...

Code of Federal Regulations, 2010 CFR

2010-01-01

... suitable for their programs, then agency heads may establish a more appropriate small business definition... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How may an agency use size... Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size...

Are Small Schools Better? School Size Considerations for Safety & Learning. Policy Brief.

ERIC Educational Resources Information Center

McRobbie, Joan

New studies from the 1990s have strengthened an already notable consensus on school size: smaller is better. This policy brief outlines research findings on why size makes a difference, how small is small enough, effective approaches to downsizing, and key barriers. No agreement exists at present on optimal school size, but research suggests a…

Interdependent effects of male and female body size plasticity on mating behaviour of predatory mites.

PubMed

Walzer, Andreas; Schausberger, Peter

2015-02-01

The adaptive canalization hypothesis predicts that traits with low phenotypic plasticity are more fitness relevant, because they have been canalized via strong past selection, than traits with high phenotypic plasticity. Based on differing male body size plasticities of the predatory mites Phytoseiulus persimilis (low plasticity) and Neoseiulus californicus (high plasticity), we accordingly hypothesized that small male body size entails higher costs in female choice and male-male competition in P. persimilis than N. californicus . Males of both species are highly polygynous but females differ in the level of polyandry (low level in P. persimilis ; medium level in N. californicus ). We videotaped the mating interactions in triplets of either P. persimilis or N. californicus , consisting of a virgin female (small or standard-sized) and a small and a standard-sized male. Mating by both small and standard-sized P. persimilis females was biased towards standard-sized males, resulting from the interplay between female preference for standard-sized males and the inferiority of small males in male-male competition. In contrast, mating by N. californicus females was equally balanced between small and standard-sized males. Small N. californicus males were more aggressive ('Napoleon complex') in male-male competition, reducing the likelihood of encounter between the standard-sized male and the female, and thus counterbalancing female preference for standard-sized males. Our results support the hypothesis that male body size is more important to fitness in the low-level polyandrous P. persimilis than in the medium-level polyandrous N. californicus and provide a key example of the implications of sexually selected body size plasticity on mating behaviour.

Interdependent effects of male and female body size plasticity on mating behaviour of predatory mites

PubMed Central

Walzer, Andreas; Schausberger, Peter

2015-01-01

The adaptive canalization hypothesis predicts that traits with low phenotypic plasticity are more fitness relevant, because they have been canalized via strong past selection, than traits with high phenotypic plasticity. Based on differing male body size plasticities of the predatory mites Phytoseiulus persimilis (low plasticity) and Neoseiulus californicus (high plasticity), we accordingly hypothesized that small male body size entails higher costs in female choice and male–male competition in P. persimilis than N. californicus. Males of both species are highly polygynous but females differ in the level of polyandry (low level in P. persimilis; medium level in N. californicus). We videotaped the mating interactions in triplets of either P. persimilis or N. californicus, consisting of a virgin female (small or standard-sized) and a small and a standard-sized male. Mating by both small and standard-sized P. persimilis females was biased towards standard-sized males, resulting from the interplay between female preference for standard-sized males and the inferiority of small males in male–male competition. In contrast, mating by N. californicus females was equally balanced between small and standard-sized males. Small N. californicus males were more aggressive (‘Napoleon complex’) in male–male competition, reducing the likelihood of encounter between the standard-sized male and the female, and thus counterbalancing female preference for standard-sized males. Our results support the hypothesis that male body size is more important to fitness in the low-level polyandrous P. persimilis than in the medium-level polyandrous N. californicus and provide a key example of the implications of sexually selected body size plasticity on mating behaviour. PMID:25673881

Identifying Preserved Storm Events on Beaches from Trenches and Cores

NASA Astrophysics Data System (ADS)

Wadman, H. M.; Gallagher, E. L.; McNinch, J.; Reniers, A.; Koktas, M.

2014-12-01

Recent research suggests that even small scale variations in grain size in the shallow stratigraphy of sandy beaches can significantly influence large-scale morphology change. However, few quantitative studies of variations in shallow stratigraphic layers, as differentiated by variations in mean grain size, have been conducted, in no small part due to the difficulty of collecting undisturbed sediment cores in the energetic lower beach and swash zone. Due to this lack of quantitative stratigraphic grain size data, most coastal morphology models assume that uniform grain sizes dominate sandy beaches, allowing for little to no temporal or spatial variations in grain size heterogeneity. In a first-order attempt to quantify small-scale, temporal and spatial variations in beach stratigraphy, thirty-five vibracores were collected at the USACE Field Research Facility (FRF), Duck, NC, in March-April of 2014 using the FRF's Coastal Research and Amphibious Buggy (CRAB). Vibracores were collected at set locations along a cross-shore profile from the toe of the dune to a water depth of ~1m in the surf zone. Vibracores were repeatedly collected from the same locations throughout a tidal cycle, as well as pre- and post a nor'easter event. In addition, two ~1.5m deep trenches were dug in the cross-shore and along-shore directions (each ~14m in length) after coring was completed to allow better interpretation of the stratigraphic sequences observed in the vibracores. The elevations of coherent stratigraphic layers, as revealed in vibracore-based fence diagrams and trench data, are used to relate specific observed stratigraphic sequences to individual storm events observed at the FRF. These data provide a first-order, quantitative examination of the small-scale temporal and spatial variability of shallow grain size along an open, sandy coastline. The data will be used to refine morphological model predictions to include variations in grain size and associated shallow stratigraphy.

Long-term patterns of body mass and stature evolution within the hominin lineage.

PubMed

Will, Manuel; Pablos, Adrián; Stock, Jay T

2017-11-01

Body size is a central determinant of a species' biology and adaptive strategy, but the number of reliable estimates of hominin body mass and stature have been insufficient to determine long-term patterns and subtle interactions in these size components within our lineage. Here, we analyse 254 body mass and 204 stature estimates from a total of 311 hominin specimens dating from 4.4 Ma to the Holocene using multi-level chronological and taxonomic analytical categories. The results demonstrate complex temporal patterns of body size variation with phases of relative stasis intermitted by periods of rapid increases. The observed trajectories could result from punctuated increases at speciation events, but also differential proliferation of large-bodied taxa or the extinction of small-bodied populations. Combined taxonomic and temporal analyses show that in relation to australopithecines, early Homo is characterized by significantly larger average body mass and stature but retains considerable diversity, including small body sizes. Within later Homo , stature and body mass evolution follow different trajectories: average modern stature is maintained from ca 1.6 Ma, while consistently higher body masses are not established until the Middle Pleistocene at ca 0.5-0.4 Ma, likely caused by directional selection related to colonizing higher latitudes. Selection against small-bodied individuals (less than 40 kg; less than 140 cm) after 1.4 Ma is associated with a decrease in relative size variability in later Homo species compared with earlier Homo and australopithecines. The isolated small-bodied individuals of Homo naledi ( ca 0.3 Ma) and Homo floresiensis ( ca 100-60 ka) constitute important exceptions to these general patterns, adding further layers of complexity to the evolution of body size within the genus Homo . At the end of the Late Pleistocene and Holocene, body size in Homo sapiens declines on average, but also extends to lower limits not seen in comparable frequency since early Homo .

Long-term patterns of body mass and stature evolution within the hominin lineage

PubMed Central

Pablos, Adrián; Stock, Jay T.

2017-01-01

Body size is a central determinant of a species' biology and adaptive strategy, but the number of reliable estimates of hominin body mass and stature have been insufficient to determine long-term patterns and subtle interactions in these size components within our lineage. Here, we analyse 254 body mass and 204 stature estimates from a total of 311 hominin specimens dating from 4.4 Ma to the Holocene using multi-level chronological and taxonomic analytical categories. The results demonstrate complex temporal patterns of body size variation with phases of relative stasis intermitted by periods of rapid increases. The observed trajectories could result from punctuated increases at speciation events, but also differential proliferation of large-bodied taxa or the extinction of small-bodied populations. Combined taxonomic and temporal analyses show that in relation to australopithecines, early Homo is characterized by significantly larger average body mass and stature but retains considerable diversity, including small body sizes. Within later Homo, stature and body mass evolution follow different trajectories: average modern stature is maintained from ca 1.6 Ma, while consistently higher body masses are not established until the Middle Pleistocene at ca 0.5–0.4 Ma, likely caused by directional selection related to colonizing higher latitudes. Selection against small-bodied individuals (less than 40 kg; less than 140 cm) after 1.4 Ma is associated with a decrease in relative size variability in later Homo species compared with earlier Homo and australopithecines. The isolated small-bodied individuals of Homo naledi (ca 0.3 Ma) and Homo floresiensis (ca 100–60 ka) constitute important exceptions to these general patterns, adding further layers of complexity to the evolution of body size within the genus Homo. At the end of the Late Pleistocene and Holocene, body size in Homo sapiens declines on average, but also extends to lower limits not seen in comparable frequency since early Homo. PMID:29291118

Management Education for Small and Medium-Sized Enterprises in the European Communities.

ERIC Educational Resources Information Center

Holzer, Rainer

This report summarizes the activities of various bodies providing training impetus for small and medium-sized enterprises (SMEs) in Europe on the three levels of (1) basic management education for potential small and medium-sized business owners and/or managers; (2) programs for small firm start-ups; and (3) activities to improve the management of…

13 CFR 107.700 - Compliance with size standards in part 121 of this chapter as a condition of Assistance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Financing of Small Businesses by Licensees Determining the Eligibility of A Small Business for Sbic Financing § 107.700 Compliance with size... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Compliance with size standards in...

Retinal projections in the electric catfish (Malapterurus electricus).

PubMed

Ebbesson, S O; O'Donnel, D

1980-01-01

The poorly developed visual system of the electric catfish was studied with silver-degeneration methods. Retinal projections were entirely contralateral to the hypothalamic optic nucleus, the lateral geniculate nucleus, the dorsomedial optic nucleus, the pretectal nuclei including the cortical nucleus, and the optic tectum. The small size and lack of differentiation of the visual system in the electric catfish suggest a relatively small role for this sensory system in this species.

Size effect on atomic structure in low-dimensional Cu-Zr amorphous systems.

PubMed

Zhang, W B; Liu, J; Lu, S H; Zhang, H; Wang, H; Wang, X D; Cao, Q P; Zhang, D X; Jiang, J Z

2017-08-04

The size effect on atomic structure of a Cu 64 Zr 36 amorphous system, including zero-dimensional small-size amorphous particles (SSAPs) and two-dimensional small-size amorphous films (SSAFs) together with bulk sample was investigated by molecular dynamics simulations. We revealed that sample size strongly affects local atomic structure in both Cu 64 Zr 36 SSAPs and SSAFs, which are composed of core and shell (surface) components. Compared with core component, the shell component of SSAPs has lower average coordination number and average bond length, higher degree of ordering, and lower packing density due to the segregation of Cu atoms on the shell of Cu 64 Zr 36 SSAPs. These atomic structure differences in SSAPs with various sizes result in different glass transition temperatures, in which the glass transition temperature for the shell component is found to be 577 K, which is much lower than 910 K for the core component. We further extended the size effect on the structure and glasses transition temperature to Cu 64 Zr 36 SSAFs, and revealed that the T g decreases when SSAFs becomes thinner due to the following factors: different dynamic motion (mean square displacement), different density of core and surface and Cu segregation on the surface of SSAFs. The obtained results here are different from the results for the size effect on atomic structure of nanometer-sized crystalline metallic alloys.

Small area estimation (SAE) model: Case study of poverty in West Java Province

NASA Astrophysics Data System (ADS)

Suhartini, Titin; Sadik, Kusman; Indahwati

2016-02-01

This paper showed the comparative of direct estimation and indirect/Small Area Estimation (SAE) model. Model selection included resolve multicollinearity problem in auxiliary variable, such as choosing only variable non-multicollinearity and implemented principal component (PC). Concern parameters in this paper were the proportion of agricultural venture poor households and agricultural poor households area level in West Java Province. The approach for estimating these parameters could be performed based on direct estimation and SAE. The problem of direct estimation, three area even zero and could not be conducted by directly estimation, because small sample size. The proportion of agricultural venture poor households showed 19.22% and agricultural poor households showed 46.79%. The best model from agricultural venture poor households by choosing only variable non-multicollinearity and the best model from agricultural poor households by implemented PC. The best estimator showed SAE better then direct estimation both of the proportion of agricultural venture poor households and agricultural poor households area level in West Java Province. The solution overcame small sample size and obtained estimation for small area was implemented small area estimation method for evidence higher accuracy and better precision improved direct estimator.

Business Creation and Technology Transfer.

ERIC Educational Resources Information Center

Martinussen, Jeff

1993-01-01

It is suggested that small- and medium-sized public universities without a commercial tradition reorganize the research administration function to serve as information clearinghouses, conduct "business intelligence," and identify new technologies and entrepreneurs among researchers. Research administration could include other practical functions…

Effect of a large-sized silicone sheet upon recovery of mastoid aeration after mastoidectomy.

PubMed

Kazama, Kyosuke; Takahashi, Haruo; Kaieda, Satoru; Iwanaga, Tetsu; Yamamoto-Fukuda, Tomomi; Yoshida, Haruo; Kumagami, Hidetaka; Takasaki, Kenji

2008-06-01

To evaluate the effect of our large-sized silicone sheet upon postoperative recovery of mastoid aeration in ears after surgery including mastoidectomy and soft-wall reconstruction (SWR). Retrospective chart review in a tertiary care center. Recovery of mastoid aeration was assessed by CT 4 to 12 months after surgery on 72 ears (69 patients), in which the silicone sheet covering from the eustachian tube (ET) to the mastoid was placed after SWR procedure with mastoidectomy were done for their chronic otitis media. Results were compared with those with a small silicone sheet. Recovery of mastoid aeration was significantly better in the large-silicone-sheet group than in the small-silicone-sheet group (chi(2) value = 11.7146, P = 0.0006). This preliminary study suggested that our large-sized silicone sheet may be effective for postoperative recovery of mastoid aeration even in ears operated with SWR procedure.

Opportunities and barriers for smaller portions in food service: lessons from marketing and behavioral economics

PubMed Central

Riis, J

2014-01-01

This paper uses the frameworks and evidence from marketing and behavioral economics to highlight the opportunities and barriers for portion control in food service environments. Applying Kahneman's ‘thinking fast and slow' concepts, it describes 10 strategies that can be effective in ‘tricking' the consumer's fast cognitive system to make better decisions and in triggering the slow cognitive system to help prevent the fast system from making bad decisions. These strategies include shrinking defaults, elongating packages, increasing the visibility of small portions, offering more mixed virtue options, adding more small sizes, offering ‘right-sized' standard portions, using meaningful size labels, adopting linear pricing, using temporal landmarks to push smaller portions and facilitating pre-commitment. For each of these strategies, I discuss the specific cost and revenue barriers that a food service operator would face if the strategy were adopted. PMID:25033960

Technique for active measurement of atmospheric transmittance using an imaging system: implementation at 10.6-μm wavelength

NASA Astrophysics Data System (ADS)

Sadot, Dan; Zaarur, O.; Zaarur, S.; Kopeika, Norman S.

1994-10-01

An active method is presented for measuring atmospheric transmittance with an imaging system. In comparison to other measurement methods, this method has the advantage of immunity to background noise, independence of atmospheric conditions such as solar radiation, and an improved capability to evaluate effects of turbulence on the measurements. Other significant advantages are integration over all particulate size distribution effects including very small and very large particulates whose concentration is hard to measure, and the fact that this method is a path-integrated measurement. In this implementation attenuation deriving from molecular absorption and from small and large particulate scatter and absorption and their weather dependences are separated out. Preliminary results indicate high correlation with direct transmittance calculations via particle size distribution measurement, and that even at 10.6 micrometers wavelength atmospheric transmission depends noticeably on aerosol size distribution and concentration.

A technique for active measurement of atmospheric transmittance using an imaging system: implementation at 10.6 μm wavelength

NASA Astrophysics Data System (ADS)

Sadot, D.; Zaarur, O.; Zaarur, S.

1995-12-01

An active method is presented for measuring atmospheric transmittance with an imaging system. In comparison to other measurement methods, this method has the advantage of immunity to background noise, independence of atmospheric conditions such as solar radiation, and an improved capability to evaluate effects of turbulence on the measurements. Other significant advantages are integration over all particulate size distribution effects including very small and very large particulates whose concentration is hard to measure, and the fact that this method is a path-integrated measurement. Attenuation deriving from molecular absorption and from small and large particulate scatter and absorption and their weather dependences are separated out. Preliminary results indicate high correlation with direct transmittance calculations via particle size distribution measurement, and that even at 10.6 μm wavelength atmospheric transmission depends noticeably on aerosol size distribution and concentration.

Opportunities and barriers for smaller portions in food service: lessons from marketing and behavioral economics.

PubMed

Riis, J

2014-07-01

This paper uses the frameworks and evidence from marketing and behavioral economics to highlight the opportunities and barriers for portion control in food service environments. Applying Kahneman's 'thinking fast and slow' concepts, it describes 10 strategies that can be effective in 'tricking' the consumer's fast cognitive system to make better decisions and in triggering the slow cognitive system to help prevent the fast system from making bad decisions. These strategies include shrinking defaults, elongating packages, increasing the visibility of small portions, offering more mixed virtue options, adding more small sizes, offering 'right-sized' standard portions, using meaningful size labels, adopting linear pricing, using temporal landmarks to push smaller portions and facilitating pre-commitment. For each of these strategies, I discuss the specific cost and revenue barriers that a food service operator would face if the strategy were adopted.

Monte Carlo calculated correction factors for diodes and ion chambers in small photon fields.

PubMed

Czarnecki, D; Zink, K

2013-04-21

The application of small photon fields in modern radiotherapy requires the determination of total scatter factors Scp or field factors Ω(f(clin), f(msr))(Q(clin), Q(msr)) with high precision. Both quantities require the knowledge of the field-size-dependent and detector-dependent correction factor k(f(clin), f(msr))(Q(clin), Q(msr)). The aim of this study is the determination of the correction factor k(f(clin), f(msr))(Q(clin), Q(msr)) for different types of detectors in a clinical 6 MV photon beam of a Siemens KD linear accelerator. The EGSnrc Monte Carlo code was used to calculate the dose to water and the dose to different detectors to determine the field factor as well as the mentioned correction factor for different small square field sizes. Besides this, the mean water to air stopping power ratio as well as the ratio of the mean energy absorption coefficients for the relevant materials was calculated for different small field sizes. As the beam source, a Monte Carlo based model of a Siemens KD linear accelerator was used. The results show that in the case of ionization chambers the detector volume has the largest impact on the correction factor k(f(clin), f(msr))(Q(clin), Q(msr)); this perturbation may contribute up to 50% to the correction factor. Field-dependent changes in stopping-power ratios are negligible. The magnitude of k(f(clin), f(msr))(Q(clin), Q(msr)) is of the order of 1.2 at a field size of 1 × 1 cm(2) for the large volume ion chamber PTW31010 and is still in the range of 1.05-1.07 for the PinPoint chambers PTW31014 and PTW31016. For the diode detectors included in this study (PTW60016, PTW 60017), the correction factor deviates no more than 2% from unity in field sizes between 10 × 10 and 1 × 1 cm(2), but below this field size there is a steep decrease of k(f(clin), f(msr))(Q(clin), Q(msr)) below unity, i.e. a strong overestimation of dose. Besides the field size and detector dependence, the results reveal a clear dependence of the correction factor on the accelerator geometry for field sizes below 1 × 1 cm(2), i.e. on the beam spot size of the primary electrons hitting the target. This effect is especially pronounced for the ionization chambers. In conclusion, comparing all detectors, the unshielded diode PTW60017 is highly recommended for small field dosimetry, since its correction factor k(f(clin), f(msr))(Q(clin), Q(msr)) is closest to unity in small fields and mainly independent of the electron beam spot size.

A small porous-plug burner for studies of combustion chemistry and soot formation

NASA Astrophysics Data System (ADS)

Campbell, M. F.; Schrader, P. E.; Catalano, A. L.; Johansson, K. O.; Bohlin, G. A.; Richards-Henderson, N. K.; Kliewer, C. J.; Michelsen, H. A.

2017-12-01

We have developed and built a small porous-plug burner based on the original McKenna burner design. The new burner generates a laminar premixed flat flame for use in studies of combustion chemistry and soot formation. The size is particularly relevant for space-constrained, synchrotron-based X-ray diagnostics. In this paper, we present details of the design, construction, operation, and supporting infrastructure for this burner, including engineering attributes that enable its small size. We also present data for charactering the flames produced by this burner. These data include temperature profiles for three premixed sooting ethylene/air flames (equivalence ratios of 1.5, 1.8, and 2.1); temperatures were recorded using direct one-dimensional coherent Raman imaging. We include calculated temperature profiles, and, for one of these ethylene/air flames, we show the carbon and hydrogen content of heavy hydrocarbon species measured using an aerosol mass spectrometer coupled with vacuum ultraviolet photoionization (VUV-AMS) and soot-volume-fraction measurements obtained using laser-induced incandescence. In addition, we provide calculated mole-fraction profiles of selected gas-phase species and characteristic profiles for seven mass peaks from AMS measurements. Using these experimental and calculated results, we discuss the differences between standard McKenna burners and the new miniature porous-plug burner introduced here.

A small porous-plug burner for studies of combustion chemistry and soot formation.

PubMed

Campbell, M F; Schrader, P E; Catalano, A L; Johansson, K O; Bohlin, G A; Richards-Henderson, N K; Kliewer, C J; Michelsen, H A

2017-12-01

We have developed and built a small porous-plug burner based on the original McKenna burner design. The new burner generates a laminar premixed flat flame for use in studies of combustion chemistry and soot formation. The size is particularly relevant for space-constrained, synchrotron-based X-ray diagnostics. In this paper, we present details of the design, construction, operation, and supporting infrastructure for this burner, including engineering attributes that enable its small size. We also present data for charactering the flames produced by this burner. These data include temperature profiles for three premixed sooting ethylene/air flames (equivalence ratios of 1.5, 1.8, and 2.1); temperatures were recorded using direct one-dimensional coherent Raman imaging. We include calculated temperature profiles, and, for one of these ethylene/air flames, we show the carbon and hydrogen content of heavy hydrocarbon species measured using an aerosol mass spectrometer coupled with vacuum ultraviolet photoionization (VUV-AMS) and soot-volume-fraction measurements obtained using laser-induced incandescence. In addition, we provide calculated mole-fraction profiles of selected gas-phase species and characteristic profiles for seven mass peaks from AMS measurements. Using these experimental and calculated results, we discuss the differences between standard McKenna burners and the new miniature porous-plug burner introduced here.

Atmospheric oxygen level and the evolution of insect body size.

PubMed

Harrison, Jon F; Kaiser, Alexander; VandenBrooks, John M

2010-07-07

Insects are small relative to vertebrates, possibly owing to limitations or costs associated with their blind-ended tracheal respiratory system. The giant insects of the late Palaeozoic occurred when atmospheric PO(2) (aPO(2)) was hyperoxic, supporting a role for oxygen in the evolution of insect body size. The paucity of the insect fossil record and the complex interactions between atmospheric oxygen level, organisms and their communities makes it impossible to definitively accept or reject the historical oxygen-size link, and multiple alternative hypotheses exist. However, a variety of recent empirical findings support a link between oxygen and insect size, including: (i) most insects develop smaller body sizes in hypoxia, and some develop and evolve larger sizes in hyperoxia; (ii) insects developmentally and evolutionarily reduce their proportional investment in the tracheal system when living in higher aPO(2), suggesting that there are significant costs associated with tracheal system structure and function; and (iii) larger insects invest more of their body in the tracheal system, potentially leading to greater effects of aPO(2) on larger insects. Together, these provide a wealth of plausible mechanisms by which tracheal oxygen delivery may be centrally involved in setting the relatively small size of insects and for hyperoxia-enabled Palaeozoic gigantism.

Size matters: concurrency and the epidemic potential of HIV in small networks.

PubMed

Carnegie, Nicole Bohme; Morris, Martina

2012-01-01

Generalized heterosexual epidemics are responsible for the largest share of the global burden of HIV. These occur in populations that do not have high rates of partner acquisition, and research suggests that a pattern of fewer, but concurrent, partnerships may be the mechanism that provides the connectivity necessary for sustained transmission. We examine how network size affects the impact of concurrency on network connectivity. We use a stochastic network model to generate a sample of networks, varying the size of the network and the level of concurrency, and compare the largest components for each scenario to the asymptotic expected values. While the threshold for the growth of a giant component does not change, the transition is more gradual in the smaller networks. As a result, low levels of concurrency generate more connectivity in small networks. Generalized HIV epidemics are by definition those that spread to a larger fraction of the population, but the mechanism may rely in part on the dynamics of transmission in a set of linked small networks. Examples include rural populations in sub-Saharan Africa and segregated minority populations in the US, where the effective size of the sexual network may well be in the hundreds, rather than thousands. Connectivity emerges at lower levels of concurrency in smaller networks, but these networks can still be disconnected with small changes in behavior. Concurrency remains a strategic target for HIV combination prevention programs in this context.

SMEs, IT, and the Third Space: Colonization and Creativity in the Theatre Industry

NASA Astrophysics Data System (ADS)

Kendall, Julie E.; Kendall, Kenneth E.

We examine how small and medium-sized, professional, nonprofit performing arts theatres in the US can improve the strategic use of information technology (IT), as well as other aspects of theatre management for large, commercial theatre productions in the West End of London and on Broadway in New York City. In this article we use the epistemology of the third space developed by Bhabha (1994) and extended by Frenkel (2008). Although both authors were discussing knowledge transfer, we use their conceptualizations to characterize and explore more deeply the transfer process of culture (and thereby useful practices and worthwhile lessons) from small and medium-sized professional, nonprofit theaters to large-scale commercial theatres. We include a discussion of Nonaka’s (1991) concept of ba, and how it relates to the third space. We specifically employ the metaphor of the third space developed by Bhabha (1994) to critique and understand the verbal and nonverbal cultural transmissions between small and large theatres. One of our contributions is to use the conceptualization and metaphor of the third space to understand the complex exchanges and relationships between small to medium-sized nonprofit professional theatres and large commercial theatres, and to identify what large commercial productions can learn from nonprofit theatres from these exchanges.

Closed ecological systems: From test tubes to Earth's biosphere

NASA Technical Reports Server (NTRS)

Frye, Robert J.; Mignon, George

1992-01-01

Artificially constructed closed ecological systems (CES) have been researched both experimentally and theoretically for over 25 years. The size of these systems have varied from less than one liter to many thousands of cubic meters in volume. The diversity of the included components has a similarly wide range from purely aquatic systems to soil based systems that incorporate many aspects of Earth's biosphere. While much has been learned about the functioning of these closed systems, much remains to be learned. In this paper, we compare and contrast the behavior of closed ecological systems of widely different sizes through an analysis of their atmospheric composition. In addition, we will compare the performance of relatively small CES with the behavior of Earth's biosphere. We address the applicability of small CES as replicable analogs for planetary biospheres and discuss the use of small CES as an experimental milieu for an examination of the evolution of extra-terrestrial colonies.

Red-cockaded Woodpecker Picoides borealis Microhabitat Characteristics and Reproductive Success in a Loblolly-Shortleaf Pine Forest

USGS Publications Warehouse

Wood, Douglas R.; Burger, L. Wesley; Vilella, Francisco

2014-01-01

We investigated the relationship between red-cockaded woodpecker (Picoides borealis) reproductive success and microhabitat characteristics in a southeastern loblolly (Pinus taeda) and shortleaf (P. echinata) pine forest. From 1997 to 1999, we recorded reproductive success parameters of 41 red-cockaded woodpecker groups at the Bienville National Forest, Mississippi. Microhabitat characteristics were measured for each group during the nesting season. Logistic regression identified understory vegetation height and small nesting season home range size as predictors of red-cockaded woodpecker nest attempts. Linear regression models identified several variables as predictors of red-cockaded woodpecker reproductive success including group density, reduced hardwood component, small nesting season home range size, and shorter foraging distances. Red-cockaded woodpecker reproductive success was correlated with habitat and behavioral characteristics that emphasize high quality habitat. By providing high quality foraging habitat during the nesting season, red-cockaded woodpeckers can successfully reproduce within small home ranges.

The use of imputed sibling genotypes in sibship-based association analysis: on modeling alternatives, power and model misspecification.

PubMed

Minică, Camelia C; Dolan, Conor V; Hottenga, Jouke-Jan; Willemsen, Gonneke; Vink, Jacqueline M; Boomsma, Dorret I

2013-05-01

When phenotypic, but no genotypic data are available for relatives of participants in genetic association studies, previous research has shown that family-based imputed genotypes can boost the statistical power when included in such studies. Here, using simulations, we compared the performance of two statistical approaches suitable to model imputed genotype data: the mixture approach, which involves the full distribution of the imputed genotypes and the dosage approach, where the mean of the conditional distribution features as the imputed genotype. Simulations were run by varying sibship size, size of the phenotypic correlations among siblings, imputation accuracy and minor allele frequency of the causal SNP. Furthermore, as imputing sibling data and extending the model to include sibships of size two or greater requires modeling the familial covariance matrix, we inquired whether model misspecification affects power. Finally, the results obtained via simulations were empirically verified in two datasets with continuous phenotype data (height) and with a dichotomous phenotype (smoking initiation). Across the settings considered, the mixture and the dosage approach are equally powerful and both produce unbiased parameter estimates. In addition, the likelihood-ratio test in the linear mixed model appears to be robust to the considered misspecification in the background covariance structure, given low to moderate phenotypic correlations among siblings. Empirical results show that the inclusion in association analysis of imputed sibling genotypes does not always result in larger test statistic. The actual test statistic may drop in value due to small effect sizes. That is, if the power benefit is small, that the change in distribution of the test statistic under the alternative is relatively small, the probability is greater of obtaining a smaller test statistic. As the genetic effects are typically hypothesized to be small, in practice, the decision on whether family-based imputation could be used as a means to increase power should be informed by prior power calculations and by the consideration of the background correlation.

Intraspecific variation in body size does not alter the effects of mesopredators on prey.

PubMed

Gallagher, Austin J; Brandl, Simon J; Stier, Adrian C

2016-12-01

As humans continue to alter the species composition and size structure of marine food webs, it is critical to understand size-dependent effects of predators on prey. Yet, how shifts in predator body size mediate the effect of predators is understudied in tropical marine ecosystems, where anthropogenic harvest has indirectly increased the density and size of small-bodied predators. Here, we combine field surveys and a laboratory feeding experiment in coral reef fish communities to show that small and large predators of the same species can have similar effects. Specifically, surveys show that the presence of a small predator ( Paracirrhites arcatus ) was correlated with lower chances of prey fish presence, but these correlations were independent of predator size. Experimental trials corroborated the size-independent effect of the predator; attack rates were indistinguishable between small and large predators, suggesting relatively even effects of hawkfish in various size classes on the same type of prey. Our results indicate that the effects of small predators on coral reefs can be size-independent, suggesting that variation in predator size-structure alone may not always affect the functional role of these predators.

Respiratory symptoms following wildfire smoke exposure: airway size as a susceptibility factor.

PubMed

Mirabelli, Maria C; Künzli, Nino; Avol, Edward; Gilliland, Frank D; Gauderman, W James; McConnell, Rob; Peters, John M

2009-05-01

Associations between exposure to smoke during wildfire events and respiratory symptoms are well documented, but the role of airway size remains unclear. We conducted this analysis to assess whether small airway size modifies these relationships. We analyzed data from 465 nonasthmatic 16- to 19-year-old participants in the Children's Health Study. Following an outbreak of wildfires in 2003, each student completed a questionnaire about smoke exposure, dry and wet cough, wheezing, and eye symptoms. We used log-binomial regression to evaluate associations between smoke exposure and fire-related health symptoms, and to assess modification of the associations by airway size. As a marker of airway size, we used the ratio of maximum midexpiratory flow to forced vital capacity. Forty percent (186 of 465) of this population (including students from 11 of 12 surveyed communities) reported the odor of wildfire smoke at home. We observed increased respiratory and eye symptoms with increasing frequency of wildfire smoke exposure. Associations between smoke exposure and having any of 4 respiratory symptoms were stronger in the lowest quartile of the lung function ratio (eg, fire smoke 6+ days: prevalence ratio: 3.8; 95% confidence interval (CI = 2.0-7.2), compared with the remaining quartiles (fire smoke 6+ days: prevalence ratio = 2.0; 1.2-3.2). Analysis of individual symptoms suggests that this interaction may be strongest for effects on wheezing. Small airways may serve as a marker of susceptibility to effects of wildfire smoke. Future studies should investigate the role of airway size for more common exposures and should include persons with asthma.

The local surface plasmon resonance property and refractive index sensitivity of metal elliptical nano-ring arrays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Weihua, E-mail: linwh-whu@hotmail.com; Wang, Qian; Dong, Anhua

2014-11-15

In this paper, we systematically investigate the optical property and refractive index sensitivity (RIS) of metal elliptical nano-ring (MENR) arranged in rectangle lattice by finite-difference time-domain method. Eight kinds of considered MENRs are divided into three classes, namely fixed at the same outer size, at the same inner size, and at the same middle size. All MENR arrays show a bonding mode local surface plasmon resonance (LSPR) peak in the near-infrared region under longitudinal and transverse polarizations, and lattice diffraction enhanced LSPR peaks emerge, when the LSPR peak wavelength (LSPRPW) matches the effective lattice constant of the array. The LSPRPWmore » is determined by the charge moving path length, the parallel and cross interactions induced by the stable distributed charges, and the moving charges inter-attraction. High RIS can be achieved by small particle distance arrays composed of MENRs with big inner size and small ring-width. On the other hand, for a MENR array, the comprehensive RIS (including RIS and figure of merit) under transverse polarization is superior to that under longitudinal polarization. Furthermore, on condition that compared arrays are fixed at the same lattice constant, the phenomenon that the RIS of big ring-width MENR arrays may be higher than that of small ring-width MENR arrays only appears in the case of compared arrays with relatively small lattice constant and composed of MENRs fixed at the same inner size simultaneously. Meanwhile, the LSPRPW of the former MENR arrays is also larger than that of the latter MENR arrays. Our systematic results may help experimentalists work with this type of systems.« less

Thrips management program for horticultural crops

USDA-ARS?s Scientific Manuscript database

This article presents a systems approach for managing key thrips pests including western flower thrips (Frankliniella occidentalis) and chilli thrips (Scirtothrips dorsalis) known to cause millions of dollars loss annually. Thrips small size (1-2 mm), thigmotactic behavior, high reproductive rate an...

Metagenomic analysis of size-fractionated picoplankton in a marine oxygen minimum zone

PubMed Central

Ganesh, Sangita; Parris, Darren J; DeLong, Edward F; Stewart, Frank J

2014-01-01

Marine oxygen minimum zones (OMZs) support diverse microbial communities with roles in major elemental cycles. It is unclear how the taxonomic composition and metabolism of OMZ microorganisms vary between particle-associated and free-living size fractions. We used amplicon (16S rRNA gene) and shotgun metagenome sequencing to compare microbial communities from large (>1.6 μm) and small (0.2–1.6 μm) filter size fractions along a depth gradient in the OMZ off Chile. Despite steep vertical redox gradients, size fraction was a significantly stronger predictor of community composition compared to depth. Phylogenetic diversity showed contrasting patterns, decreasing towards the anoxic OMZ core in the small size fraction, but exhibiting maximal values at these depths within the larger size fraction. Fraction-specific distributions were evident for key OMZ taxa, including anammox planctomycetes, whose coding sequences were enriched up to threefold in the 0.2–1.6 μm community. Functional gene composition also differed between fractions, with the >1.6 μm community significantly enriched in genes mediating social interactions, including motility, adhesion, cell-to-cell transfer, antibiotic resistance and mobile element activity. Prokaryotic transposase genes were three to six fold more abundant in this fraction, comprising up to 2% of protein-coding sequences, suggesting that particle surfaces may act as hotbeds for transposition-based genome changes in marine microbes. Genes for nitric and nitrous oxide reduction were also more abundant (three to seven fold) in the larger size fraction, suggesting microniche partitioning of key denitrification steps. These results highlight an important role for surface attachment in shaping community metabolic potential and genome content in OMZ microorganisms. PMID:24030599

Metagenomic analysis of size-fractionated picoplankton in a marine oxygen minimum zone.

PubMed

Ganesh, Sangita; Parris, Darren J; DeLong, Edward F; Stewart, Frank J

2014-01-01

Marine oxygen minimum zones (OMZs) support diverse microbial communities with roles in major elemental cycles. It is unclear how the taxonomic composition and metabolism of OMZ microorganisms vary between particle-associated and free-living size fractions. We used amplicon (16S rRNA gene) and shotgun metagenome sequencing to compare microbial communities from large (>1.6 μm) and small (0.2-1.6 μm) filter size fractions along a depth gradient in the OMZ off Chile. Despite steep vertical redox gradients, size fraction was a significantly stronger predictor of community composition compared to depth. Phylogenetic diversity showed contrasting patterns, decreasing towards the anoxic OMZ core in the small size fraction, but exhibiting maximal values at these depths within the larger size fraction. Fraction-specific distributions were evident for key OMZ taxa, including anammox planctomycetes, whose coding sequences were enriched up to threefold in the 0.2-1.6 μm community. Functional gene composition also differed between fractions, with the >1.6 μm community significantly enriched in genes mediating social interactions, including motility, adhesion, cell-to-cell transfer, antibiotic resistance and mobile element activity. Prokaryotic transposase genes were three to six fold more abundant in this fraction, comprising up to 2% of protein-coding sequences, suggesting that particle surfaces may act as hotbeds for transposition-based genome changes in marine microbes. Genes for nitric and nitrous oxide reduction were also more abundant (three to seven fold) in the larger size fraction, suggesting microniche partitioning of key denitrification steps. These results highlight an important role for surface attachment in shaping community metabolic potential and genome content in OMZ microorganisms.

Ecological Interactions in Dinosaur Communities: Influences of Small Offspring and Complex Ontogenetic Life Histories

PubMed Central

Codron, Daryl; Carbone, Chris; Clauss, Marcus

2013-01-01

Because egg-laying meant that even the largest dinosaurs gave birth to very small offspring, they had to pass through multiple ontogenetic life stages to adulthood. Dinosaurs’ successors as the dominant terrestrial vertebrate life form, the mammals, give birth to live young, and have much larger offspring and less complex ontogenetic histories. The larger number of juveniles in dinosaur as compared to mammal ecosystems represents both a greater diversity of food available to predators, and competitors for similar-sized individuals of sympatric species. Models of population abundances across different-sized species of dinosaurs and mammals, based on simulated ecological life tables, are employed to investigate how differences in predation and competition pressure influenced dinosaur communities. Higher small- to medium-sized prey availability leads to a normal body mass-species richness (M-S) distribution of carnivorous dinosaurs (as found in the theropod fossil record), in contrast to the right-skewed M-S distribution of carnivorous mammals (as found living members of the order Carnivora). Higher levels of interspecific competition leads to a left-skewed M-S distribution in herbivorous dinosaurs (as found in sauropods and ornithopods), in contrast to the normal M-S distribution of large herbivorous mammals. Thus, our models suggest that differences in reproductive strategy, and consequently ontogeny, explain observed differences in community structure between dinosaur and mammal faunas. Models also show that the largest dinosaurian predators could have subsisted on similar-sized prey by including younger life stages of the largest herbivore species, but that large predators likely avoided prey much smaller than themselves because, despite predicted higher abundances of smaller than larger-bodied prey, contributions of small prey to biomass intake would be insufficient to satisfy meat requirements. A lack of large carnivores feeding on small prey exists in mammals larger than 21.5 kg, and it seems a similar minimum prey-size threshold could have affected dinosaurs as well. PMID:24204749

Ecological interactions in dinosaur communities: influences of small offspring and complex ontogenetic life histories.

PubMed

Codron, Daryl; Carbone, Chris; Clauss, Marcus

2013-01-01

Because egg-laying meant that even the largest dinosaurs gave birth to very small offspring, they had to pass through multiple ontogenetic life stages to adulthood. Dinosaurs' successors as the dominant terrestrial vertebrate life form, the mammals, give birth to live young, and have much larger offspring and less complex ontogenetic histories. The larger number of juveniles in dinosaur as compared to mammal ecosystems represents both a greater diversity of food available to predators, and competitors for similar-sized individuals of sympatric species. Models of population abundances across different-sized species of dinosaurs and mammals, based on simulated ecological life tables, are employed to investigate how differences in predation and competition pressure influenced dinosaur communities. Higher small- to medium-sized prey availability leads to a normal body mass-species richness (M-S) distribution of carnivorous dinosaurs (as found in the theropod fossil record), in contrast to the right-skewed M-S distribution of carnivorous mammals (as found living members of the order Carnivora). Higher levels of interspecific competition leads to a left-skewed M-S distribution in herbivorous dinosaurs (as found in sauropods and ornithopods), in contrast to the normal M-S distribution of large herbivorous mammals. Thus, our models suggest that differences in reproductive strategy, and consequently ontogeny, explain observed differences in community structure between dinosaur and mammal faunas. Models also show that the largest dinosaurian predators could have subsisted on similar-sized prey by including younger life stages of the largest herbivore species, but that large predators likely avoided prey much smaller than themselves because, despite predicted higher abundances of smaller than larger-bodied prey, contributions of small prey to biomass intake would be insufficient to satisfy meat requirements. A lack of large carnivores feeding on small prey exists in mammals larger than 21.5 kg, and it seems a similar minimum prey-size threshold could have affected dinosaurs as well.

A new perspective on the raindrop size distribution and its implications for retrievals of light rainfall

NASA Astrophysics Data System (ADS)

Gatlin, P. N.; Thurai, M.; Petersen, W. A.; Bringi, V. N.

2017-12-01

As GPM facilitates precipitation estimation at higher latitudes where light rainfall is more common it becomes more important that we can fully describe the raindrop size distribution (RSD) across the continuum of observed raindrop sizes. An adequate understanding and the capability to represent the RSD in light rain and drizzle extends from GPM radar algorithms into radiometer-based algorithms, where auto-conversion from cloud to rainwater contents and size distributions becomes important for light rain/drizzle estimation. This study provides insights into the effect of small raindrops on our ability to accurately map rainfall. The RSD has been widely defined using a gamma distribution—the assumption often being verified and approach being reinforced using measurements that imperfectly measure the small end of the RSD. However, we find that the gamma model as it is applied in its current form, to include commonly used disdrometer measurements to define it, is not capable of accurately describing the small raindrops we have observed during light rainfall. We demonstrate the difficulty encountered at light rain rates (e.g., 0.5 mm/hr or less) and for drops typically < 0.6 - 0.7 mm in diameter using a disdrometer with a pixel resolution of 50 microns operated alongside a 2DVD, with both instruments inside a small DFIR wind fence. Measurements were made in two locations with different climates—Greely, Colorado and Huntsville, Alabama. The resultant comparison reveals that the gamma RSD model overestimates the characteristic raindrop diameter (Dm), especially for light rainfall. A generalized gamma distribution provides a closer fit to the RSD observations across the continuum of raindrop sizes and highlights a drizzle mode of the RSD exists that would otherwise not be described with the commonly used gamma RSD model. Our analysis also suggests that RSD-based separation of stratiform and convective rainfall requires special consideration for light rainfall cases, especially those with small mass-weighted mean diameters (Dm < 0.6 mm).

Effect of Pitch Size on Technical-Tactical Actions of the Goalkeeper in Small-Sided Games

PubMed Central

Jara, Daniel; Ortega, Enrique; Gómez, Miguel-Ángel; de Baranda, Pilar Sainz

2018-01-01

Abstract The aim of this paper was to determine how the size of the pitch affected technical and tactical actions of the goalkeeper when playing small-sided games. The participants were 13 male youth players, including 3 goalkeepers. Three different pitch sizes were used (62 x 44 m; 50 x 35 m; 32 x 23 m). On each pitch, the players played three matches of 8 minutes, with 5-minute breaks between matches. Numerous variables were recorded and examined: defensive and offensive technical and tactical actions, opponent’s shooting zone, length and zone of the offensive action, and goal zone where the shoot was directed. An ad hoc observational tool was used. A descriptive analysis was described. The Fisher’s exact test was used when the expected distribution was below 5 or included values below 1%. Statistical significance was set at p < 0.05. The results showed that the technical-tactical actions of the goalkeeper differed among pitch sizes. In defensive actions, when the pitch was larger, the 1-on-1 situations took precedence, whereas when the pitch was smaller, the proportion of blocks increased. In offensive actions, the goalkeepers did not show a wide variety of actions when the pitch was larger, but when the pitch was smaller, passes with a hand or foot increased. These results show that the size should be taken into account when planning and designing tasks. PMID:29922387

Neck circumference correlates with tumor size and lateral lymph node metastasis in men with small papillary thyroid carcinoma.

PubMed

Kim, Mi Ra; Kim, Sang Soo; Huh, Jung Eun; Lee, Byung Joo; Lee, Jin Choon; Jeon, Yun Kyung; Kim, Bo Hyun; Kim, Seong Jang; Wang, Soo Geun; Kim, Yong Ki; Kim, In Joo

2013-01-01

Obesity is correlated with numerous diseases, including thyroid cancer, but the clinical significance of obesity with regard to the clinical characteristics of thyroid cancer remains unclear. Neck circumference is an index of upper-body adipose tissue distribution. In total, 401 patients with papillary thyroid carcinoma (PTC) measuring ≤ 2 cm were included. Neck circumference was measured horizontally at the level just below the thyroid cartilage on preoperative neck computed tomographic images. Neck circumference correlated significantly with tumor size in men (p = 0.001) but not in women (p = 0.930). Body mass index (BMI) did not significantly correlate with tumor size in either sex. Neck circumference was significantly larger in men with lateral lymph node (LN) metastasis than in those without (p = 0.004). Neck circumference and BMI did not differ significantly in women according to other factors such as tumor size, multifocality, extrathyroid extension, and LN metastasis. Tumor size and the prevalence of lateral LN metastasis in men tended to increase in the middle/large neck circumference subgroup compared with those in the low neck circumference subgroup. Multivariate logistic regression analysis revealed that neck circumference (p = 0.009) was a predictor for the presence of lateral LN metastasis in men. BMI was not a predictive factor for lateral LN involvement in either sex. Neck circumference, an indicator of central or visceral obesity but not BMI, may be associated with some prognostic factors in men with small PTC.

Renormalization group and Ward identities for infrared QED4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mastropietro, Vieri

2007-10-15

A regularized version of Euclidean QED4 in the Feynman gauge is considered, with a fixed ultraviolet cutoff, photon mass of the size of the cutoff, and any value, including zero, of the electron mass. We will prove that the Schwinger functions are expressed by convergent series for small values of the charge and verify the Ward identities, up to corrections which are small for momentum scales far from the ultraviolet cutoff.

Body size and violent offending among males in the Northern Finland 1966 birth cohort.

PubMed

Ikäheimo, Pauliina; Räsänen, Pirkko; Hakko, Helinä; Hartikainen, Anna-Liisa; Laitinen, Jaana; Hodgins, Sheilagh; Tiihonen, Jari

2007-10-01

Childhood onset aggressive behavior is one of the most stable human characteristics. Previous literature indicates that this behavioral trait may be associated with body size. The present study investigated the association between body sizes at different ages and committing violent crimes in adulthood. The Northern Finland 1966 Birth Cohort includes 5636 males followed up to age 31 years prospectively. Information on criminality was extracted from official records. Body sizes were measured at birth, 12 months and 14 years of age, and compared the violent and the non-violent offenders with the non-offenders. Optimal cut-off points for each of the body size measures for the differentiation of the three groups were identified. Odds ratios were adjusted taking account of maternal age, socioeconomic status of the family of origin, mother's marital status, parity, smoking during pregnancy, gestational age and unwanted pregnancy. Both high body mass index (BMI) and small head circumference at 12 months were associated with increased risk of violent offending (adjusted ORs 1.6-1.8). High BMI at 12 months combined with small head circumference was associated with substantially increased risk of violent offending (OR 4.2, 95% CI 2.6-6.8). In males, small head circumference and large body size at 12 months of age were strongly associated with an increased risk of violent, but not non-violent offending in adulthood. The measures at 12 months were the strongest predictors, suggesting that this association may be explained by genetic or early environmental factors, rather than social learning later in childhood and adolescence.

Ontogenetic prey size selection in snakes: predator size and functional limitations to handling minimum prey sizes.

PubMed

Hampton, Paul M

2018-02-01

As body size increases, some predators eliminate small prey from their diet exhibiting an ontogenetic shift toward larger prey. In contrast, some predators show a telescoping pattern of prey size in which both large and small prey are consumed with increasing predator size. To explore a functional explanation for the two feeding patterns, I examined feeding effort as both handling time and number of upper jaw movements during ingestion of fish of consistent size. I used a range of body sizes from two snake species that exhibit ontogenetic shifts in prey size (Nerodia fasciata and N. rhombifer) and a species that exhibits telescoping prey size with increased body size (Thamnophis proximus). For the two Nerodia species, individuals with small or large heads exhibited greater difficulty in feeding effort compared to snakes of intermediate size. However, for T. proximus measures of feeding effort were negatively correlated with head length and snout-vent length (SVL). These data indicate that ontogenetic shifters of prey size develop trophic morphology large enough that feeding effort increases for disproportionately small prey. I also compared changes in body size among the two diet strategies for active foraging snake species using data gleaned from the literature to determine if increased change in body size and thereby feeding morphology is observable in snakes regardless of prey type or foraging habitat. Of the 30 species sampled from literature, snakes that exhibit ontogenetic shifts in prey size have a greater magnitude of change in SVL than species that have telescoping prey size patterns. Based upon the results of the two data sets above, I conclude that ontogenetic shifts away from small prey occur in snakes due, in part, to growth of body size and feeding structures beyond what is efficient for handling small prey. Copyright © 2017. Published by Elsevier GmbH.

Relationship between pineal cyst size and aqueductal CSF flow measured by phase contrast MRI.

PubMed

Bezuidenhout, Abraham F; Kasper, Ekkehard M; Baledent, Olivier; Rojas, Rafael; Bhadelia, Rafeeque A

2018-02-23

Most patients with pineal cysts referred for neurosurgical consultation have no specific symptoms or objective findings except for pineal cyst size to help in management decisions. Our purpose was to assess the relationship between pineal cyst size and aqueductal CSF flow using PC-MRI. Eleven adult patients with pineal cysts (> 1-cm in size) referred for neurosurgical consultations were included. Cyst volume was calculated using 3D T1 images. PC-MRI in axial plane with velocity encoding of 5 cm/sec was used to quantitatively assess CSF flow through the cerebral aqueduct to determine the aqueductal stroke volume, which was then correlated to cyst size using Pearson's correlation. Pineal cysts were grouped by size into small (6/11) and large (5/11) using the median value to compare aqueductal stroke volume using Mann-Whitney test. Patients were 39 ± 13 years (mean ± SD) of age, and 10/11 (91%) were female. There was significant negative correlation between cyst volume and aqueductal stroke volume (r=0.74; p=0.009). Volume of small cysts (4954±2157 mm3) was significantly different compared to large cysts (13752±3738 mm3; p= 0.008). The aqueductal stroke volume of patients harboring large cysts 33±8 μL/cardiac cycle was significantly lower than that of patients with small cysts 96±29 μL/cardiac cycle (p=0.008). Aqueductal CSF flow appears to decrease with increasing pineal cyst size. Our preliminary results provide first evidence that even in the absence of objective neurological findings or hydrocephalus; larger pineal cysts already display decreased CSF flow through the cerebral aqueduct.

Small ponds play big role in greenhouse gas emissions from inland waters

NASA Astrophysics Data System (ADS)

Holgerson, M.; Raymond, P. A.

2017-12-01

Inland waters are an important part of the global carbon cycle, but there is uncertainty in estimating their greenhouse gas emissions. Uncertainty stems from different models and variable estimates of surface water gas concentrations, gas exchange rates, and the global size distribution of water bodies. Emissions from small water bodies are especially difficult to estimate because they are not globally mapped and few studies have assessed their greenhouse gas concentrations and gas exchange rates. To overcome these limitations, we studied greenhouse gases and gas exchange rates in small ponds in temperate forests of the northeastern United States. We then compiled our data with direct measurements of CO2 and CH4 concentrations from 427 ponds and lakes worldwide, and upscaled to estimate greenhouse gas emissions using estimates of gas exchange rates and the size distribution of lakes. We found that small ponds play a disproportionately large role in greenhouse gas emissions. While small ponds only account for about 9% of global lakes and ponds by area, they contribute 15% of CO2 and 41% of diffusive CH4 emissions from inland freshwaters. Secondly, we measured gas exchange velocities (k) in small ponds and compiled direct measurements of k from 67 global water bodies. We found that k is low but highly variable in small ponds, and increases and becomes even more variable with lake size, a finding that is not currently included in global carbon models. In a third study, we found that gas exchange in small ponds is highly sensitive to overnight cooling, which can lead to short bursts of increased k at night, with implications for greenhouse gas emissions. Overall, these studies show that small ponds are a critical part of the global carbon cycle, and also highlight many knowledge gaps. Therefore, understanding small pond carbon cycling is an important research priority.

Evaluation of attenuation and scatter correction requirements in small animal PET and SPECT imaging

NASA Astrophysics Data System (ADS)

Konik, Arda Bekir

Positron emission tomography (PET) and single photon emission tomography (SPECT) are two nuclear emission-imaging modalities that rely on the detection of high-energy photons emitted from radiotracers administered to the subject. The majority of these photons are attenuated (absorbed or scattered) in the body, resulting in count losses or deviations from true detection, which in turn degrades the accuracy of images. In clinical emission tomography, sophisticated correction methods are often required employing additional x-ray CT or radionuclide transmission scans. Having proven their potential in both clinical and research areas, both PET and SPECT are being adapted for small animal imaging. However, despite the growing interest in small animal emission tomography, little scientific information exists about the accuracy of these correction methods on smaller size objects, and what level of correction is required. The purpose of this work is to determine the role of attenuation and scatter corrections as a function of object size through simulations. The simulations were performed using Interactive Data Language (IDL) and a Monte Carlo based package, Geant4 application for emission tomography (GATE). In IDL simulations, PET and SPECT data acquisition were modeled in the presence of attenuation. A mathematical emission and attenuation phantom approximating a thorax slice and slices from real PET/CT data were scaled to 5 different sizes (i.e., human, dog, rabbit, rat and mouse). The simulated emission data collected from these objects were reconstructed. The reconstructed images, with and without attenuation correction, were compared to the ideal (i.e., non-attenuated) reconstruction. Next, using GATE, scatter fraction values (the ratio of the scatter counts to the total counts) of PET and SPECT scanners were measured for various sizes of NEMA (cylindrical phantoms representing small animals and human), MOBY (realistic mouse/rat model) and XCAT (realistic human model) digital phantoms. In addition, PET projection files for different sizes of MOBY phantoms were reconstructed in 6 different conditions including attenuation and scatter corrections. Selected regions were analyzed for these different reconstruction conditions and object sizes. Finally, real mouse data from the real version of the same small animal PET scanner we modeled in our simulations were analyzed for similar reconstruction conditions. Both our IDL and GATE simulations showed that, for small animal PET and SPECT, even the smallest size objects (˜2 cm diameter) showed ˜15% error when both attenuation and scatter were not corrected. However, a simple attenuation correction using a uniform attenuation map and object boundary obtained from emission data significantly reduces this error in non-lung regions (˜1% for smallest size and ˜6% for largest size). In lungs, emissions values were overestimated when only attenuation correction was performed. In addition, we did not observe any significant improvement between the uses of uniform or actual attenuation map (e.g., only ˜0.5% for largest size in PET studies). The scatter correction was not significant for smaller size objects, but became increasingly important for larger sizes objects. These results suggest that for all mouse sizes and most rat sizes, uniform attenuation correction can be performed using emission data only. For smaller sizes up to ˜ 4 cm, scatter correction is not required even in lung regions. For larger sizes if accurate quantization needed, additional transmission scan may be required to estimate an accurate attenuation map for both attenuation and scatter corrections.

77 FR 76215 - Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-27

... overall goal of simplification and maximization of benefits for small businesses, SBA proposed amendments... franchisee. F. Section 121.704--When SBA Determines Size and Eligibility SBA's proposed regulations for the...

77 FR 39321 - Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-02

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78 FR 6845 - Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

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2013-01-31

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78 FR 16031 - Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

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2013-03-13

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48 CFR 19.303 - Determining North American Industry Classification System codes and size standards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Industry Classification System codes and size standards. 19.303 Section 19.303 Federal Acquisition... of Small Business Status for Small Business Programs 19.303 Determining North American Industry... North American Industry Classification System (NAICS) code and related small business size standard and...

Managers' Understanding of Workplace Health Promotion within Small and Medium-Sized Enterprises: A Phenomenological Study

ERIC Educational Resources Information Center

Moore, Ann; Parahoo, Kader; Fleming, Paul

2011-01-01

Objective: This study aimed at exploring managers' understanding of workplace health promotion and experiences of workplace health promotion activity within small and medium-sized enterprises. Design: A Heideggerian interpretive phenomenological methodology was adopted. Setting: This study was undertaken with small and medium-sized enterprise…

77 FR 8325 - Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-14

... 225, Rechargeable Lithium Batteries and Battery Systems, Small and Medium Size AGENCY: Federal... Committee 225, Rechargeable Lithium Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA..., Rechargeable Lithium Batteries and Battery Systems, Small and Medium Size. DATES: The meeting will be held...

78 FR 55773 - Fourteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-11

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78 FR 38093 - Thirteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

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2013-06-25

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A possible divot in the Kuiper belt's scattered-object size distribution

NASA Astrophysics Data System (ADS)

Shankman, C.; Kavelaars, J.; Gladman, B.; Petit, J.

2014-07-01

The formation and evolution history of the Solar System, while not directly accessible, has measurable signatures in the present-day size distributions of the Trans-Neptunian Object (TNO) populations. The form of the size distribution is modelled as a power law with number going as size to some characteristic slope. Recent works have shown that a single power law does not match the observations across all sizes; the power law breaks to a different form [1, 2, 3]. The large- size objects record the accretion history, while the small-size objects record the collision history. The changes of size-distribution shape and slope as one moves from 'large' to 'medium' to 'small' KBOs are the signature needed to constrain the formation and collision history of the Solar System. The scattering TNOs are those TNOs undergoing strong (scattering) interactions Neptune. The scattering objects can come to pericentre in the giant planet region. This close-in pericentre passage allows for the observation of smaller objects, and thus for the constraint of the small-size end of the size distribution. Our recent analysis of the Canada France Ecliptic Plane Survey's (CFEPS) scattering objects revealed an exciting potential form for the scattering object size distribution - a divot (see Figure). Our divot (a sharp drop in the number of objects per unit size which then returns at a potentially different slope) matches our observations well and can simultaneously explain observed features in other inclined (so-called "hot") Kuiper Belt populations. In this scenario all of the hot populations would share the same source and have been implanted in the outer solar system through scattering processes. If confirmed, our divot would represent a new exciting paradigm for the formation history of the Kuiper Belt. Here we present the results of an extension of our previous work to include a new, deeper, Kuiper Belt survey. By the addition of two new faint scattering objects from this survey which, in tandem with the full characterizations of the survey's biases (acting like non- detections limits), we better constrain the form of the scattering object size distribution.

Genome size diversity in angiosperms and its influence on gene space.

PubMed

Dodsworth, Steven; Leitch, Andrew R; Leitch, Ilia J

2015-12-01

Genome size varies c. 2400-fold in angiosperms (flowering plants), although the range of genome size is skewed towards small genomes, with a mean genome size of 1C=5.7Gb. One of the most crucial factors governing genome size in angiosperms is the relative amount and activity of repetitive elements. Recently, there have been new insights into how these repeats, previously discarded as 'junk' DNA, can have a significant impact on gene space (i.e. the part of the genome comprising all the genes and gene-related DNA). Here we review these new findings and explore in what ways genome size itself plays a role in influencing how repeats impact genome dynamics and gene space, including gene expression. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Development and testing of a unique carousel wind tunnel to experimentally determine the effect of gravity and the interparticle force on the physics of wind-blown particles

NASA Technical Reports Server (NTRS)

Leach, R. N.; Greeley, Ronald; White, Bruce R.; Iversen, James D.

1987-01-01

In the study of planetary aeolian processes the effect of gravity is not readily modeled. Gravity appears in the equations of particle motion along with the interparticle forces but the two are not separable. A wind tunnel that perimits multiphase flow experiments with wind blown particles at variable gravity was built and experiments were conducted at reduced gravity. The equations of particle motion initiation (saltation threshold) with variable gravity were experimentally verified and the interparticle force was separated. A uniquely design Carousel Wind Tunnel (CWT) allows for the long flow distance in a small sized tunnel since the test section if a continuous loop and develops the required turbulent boundary layer. A prototype model of the tunnel where only the inner drum rotates was built and tested in the KC-135 Weightless Wonder 4 zero-g aircraft. Future work includes further experiments with walnut shell in the KC-135 which sharply graded particles of widely varying median sizes including very small particles to see how interparticle force varies with particle size, and also experiments with other aeolian material.

Podocyte Number in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells

PubMed Central

Puelles, Victor G.; Douglas-Denton, Rebecca N.; Cullen-McEwen, Luise A.; Li, Jinhua; Hughson, Michael D.; Hoy, Wendy E.; Kerr, Peter G.

2015-01-01

Increases in glomerular size occur with normal body growth and in many pathologic conditions. In this study, we determined associations between glomerular size and numbers of glomerular resident cells, with a particular focus on podocytes. Kidneys from 16 male Caucasian-Americans without overt renal disease, including 4 children (≤3 years old) to define baseline values of early life and 12 adults (≥18 years old), were collected at autopsy in Jackson, Mississippi. We used a combination of immunohistochemistry, confocal microscopy, and design-based stereology to estimate individual glomerular volume (IGV) and numbers of podocytes, nonepithelial cells (NECs; tuft cells other than podocytes), and parietal epithelial cells (PECs). Podocyte density was calculated. Data are reported as medians and interquartile ranges (IQRs). Glomeruli from children were small and contained 452 podocytes (IQR=335–502), 389 NECs (IQR=265–498), and 146 PECs (IQR=111–206). Adult glomeruli contained significantly more cells than glomeruli from children, including 558 podocytes (IQR=431–746; P<0.01), 1383 NECs (IQR=998–2042; P<0.001), and 367 PECs (IQR=309–673; P<0.001). However, large adult glomeruli showed markedly lower podocyte density (183 podocytes per 106 µm3) than small glomeruli from adults and children (932 podocytes per 106 µm3; P<0.001). In conclusion, large adult glomeruli contained more podocytes than small glomeruli from children and adults, raising questions about the origin of these podocytes. The increased number of podocytes in large glomeruli does not match the increase in glomerular size observed in adults, resulting in relative podocyte depletion. This may render hypertrophic glomeruli susceptible to pathology. PMID:25568174

Incorporating Allee effects into the potential biological removal level

USGS Publications Warehouse

Hadier, Humza; Oldfield, Sarah; Tu, Tiffany; Moreno, Rosa; Diffendorfer, Jay E.; Eager, Eric A.; Erickson, Richard A.

2017-01-01

Potential biological removal (PBR) is an approach used to calculate sustainable harvest and “take” limits for populations. PBR was originally derived assuming logistic growth while ignoring the effects of small population size (i.e., an Allee effect). We derived a version of PBR that includes an Allee effect (i.e., small population size or densities limiting population growth rates). We found that PBR becomes less conservative when it fails to consider an Allee effect. Specifically, sustainable harvest and take levels based upon PBR with an Allee effect were between approximately 51% and 66% of levels based upon PBR without an Allee effect. Managers and biologists using PBR may need to consider the limitations if an Allee effect may be present in the species being modeled.

Microfluidic interconnects

DOEpatents

Benett, William J.; Krulevitch, Peter A.

2001-01-01

A miniature connector for introducing microliter quantities of solutions into microfabricated fluidic devices, and which incorporates a molded ring or seal set into a ferrule cartridge, with or without a compression screw. The fluidic connector, for example, joins standard high pressure liquid chromatography (HPLC) tubing to 1 mm diameter holes in silicon or glass, enabling ml-sized volumes of sample solutions to be merged with .mu.l-sized devices. The connector has many features, including ease of connect and disconnect; a small footprint which enables numerous connectors to be located in a small area; low dead volume; helium leak-tight; and tubing does not twist during connection. Thus the connector enables easy and effective change of microfluidic devices and introduction of different solutions in the devices.

Energetic constraints, size gradients, and size limits in benthic marine invertebrates.

PubMed

Sebens, Kenneth P

2002-08-01

Populations of marine benthic organisms occupy habitats with a range of physical and biological characteristics. In the intertidal zone, energetic costs increase with temperature and aerial exposure, and prey intake increases with immersion time, generating size gradients with small individuals often found at upper limits of distribution. Wave action can have similar effects, limiting feeding time or success, although certain species benefit from wave dislodgment of their prey; this also results in gradients of size and morphology. The difference between energy intake and metabolic (and/or behavioral) costs can be used to determine an energetic optimal size for individuals in such populations. Comparisons of the energetic optimal size to the maximum predicted size based on mechanical constraints, and the ensuing mortality schedule, provides a mechanism to study and explain organism size gradients in intertidal and subtidal habitats. For species where the energetic optimal size is well below the maximum size that could persist under a certain set of wave/flow conditions, it is probable that energetic constraints dominate. When the opposite is true, populations of small individuals can dominate habitats with strong dislodgment or damage probability. When the maximum size of individuals is far below either energetic optima or mechanical limits, other sources of mortality (e.g., predation) may favor energy allocation to early reproduction rather than to continued growth. Predictions based on optimal size models have been tested for a variety of intertidal and subtidal invertebrates including sea anemones, corals, and octocorals. This paper provides a review of the optimal size concept, and employs a combination of the optimal energetic size model and life history modeling approach to explore energy allocation to growth or reproduction as the optimal size is approached.

Kepler Small Habitable Zone Planets

NASA Image and Video Library

2015-07-23

Of the 1,030 confirmed planets from Kepler, a dozen are less than twice the size of Earth and reside in the habitable zone of their host stars. In this diagram, the sizes of the exoplanets are represented by the size of each sphere. These are arranged by size from left to right, and by the type of star they orbit, from the M stars that are significantly cooler and smaller than the sun, to the K stars that are somewhat cooler and smaller than the sun, to the G stars that include the sun. The sizes of the planets are enlarged by 25 times compared to the stars. The Earth is shown for reference. http://photojournal.jpl.nasa.gov/catalog/PIA19827

13 CFR 121.301 - What size standards are applicable to financial assistance programs?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false What size standards are applicable to financial assistance programs? 121.301 Section 121.301 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size...

13 CFR 121.301 - What size standards are applicable to financial assistance programs?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What size standards are applicable to financial assistance programs? 121.301 Section 121.301 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size...

Evaluation of Small-Sized Platinum Resistance Thermometers with ITS-90 Characteristics

NASA Astrophysics Data System (ADS)

Yamazawa, K.; Anso, K.; Widiatmo, J. V.; Tamba, J.; Arai, M.

2011-12-01

Many platinum resistance thermometers (PRTs) are applied for high precision temperature measurements in industry. Most of the applications use PRTs that follow the industrial standard of PRTs, IEC 60751. However, recently, some applications, such as measurements of the temperature distribution within equipments, require a more precise temperature scale at the 0.01 °C level. In this article the evaluation of remarkably small-sized PRTs that have temperature-resistance characteristics very close to that of standard PRTs of the International Temperature Scale of 1990 (ITS-90) is reported. Two types of the sensing element were tested, one is 1.2 mm in diameter and 10 mm long, the other is 0.8 mm and 8 mm. The resistance of the sensor is 100 Ω at the triple-point-of-water temperature. The resistance ratio at the Ga melting-point temperature of the sensing elements exceeds 1.11807. To verify the closeness of the temperature-resistance characteristics, comparison measurements up to 157 °C were employed. A pressure-controlled water heat-pipe furnace was used for the comparison measurement. Characteristics of 19 thermometers with these small-sized sensing elements were evaluated. The deviation from the temperature measured using a standard PRT used as a reference thermometer in the comparison was remarkably small, when we apply the same interpolating function for the ITS-90 sub-range to these small thermometers. Results including the stability of the PRTs and the uncertainty evaluation of the comparison measurements, and the comparison results showing the small deviation from the ITS-90 temperature-resistance characteristics are reported. The development of such a PRT might be a good solution for applications such as temperature measurements of small objects or temperature distribution measurements that need the ITS-90 temperature scale.

Affordable Development and Demonstration of a Small NTR Engine and Stage: How Small is Big Enough?

NASA Technical Reports Server (NTRS)

Borowski, S. K.; Sefcik, R. J.; Fittje, J. E.; McCurdy, D. R.; Qualls, A. L.; Schnitzler, B. G.; Werner, J.; Weitzberg, A.; Joyner, C. R.

2015-01-01

In FY11, NASA formulated a plan for Nuclear Thermal Propulsion (NTP) development that included Foundational Technology Development followed by system-level Technology Demonstrations The ongoing NTP project, funded by NASAs Advanced Exploration Systems (AES) program, is focused on Foundational Technology Development and includes 5 key task activities:(1) Fuel element fabrication and non-nuclear validation testing of heritage fuel options;(2) Engine conceptual design;(3) Mission analysis and engine requirements definition;(4) Identification of affordable options for ground testing; and(5) Formulation of an affordable and sustainable NTP development program Performance parameters for Point of Departure designs for a small criticality-limited and full size 25 klbf-class engine were developed during FYs 13-14 using heritage fuel element designs for both RoverNERVA Graphite Composite (GC) and Ceramic Metal (Cermet) fuel forms To focus the fuel development effort and maximize use of its resources, the AES program decided, in FY14, that a leader-follower down selection between GC and cermet fuel was required An Independent Review Panel (IRP) was convened by NASA and tasked with reviewing the available fuel data and making a recommendation to NASA. In February 2015, the IRP recommended and the AES program endorsed GC as the leader fuel In FY14, a preliminary development schedule DDTE plan was produced by GRC, DOE industry for the AES program. Assumptions, considerations and key task activities are presented here Two small (7.5 and 16.5 klbf) engine sizes were considered for ground and flight technology demonstration within a 10-year timeframe; their ability to support future human exploration missions was also examined and a recommendation on a preferred size is provided.

A continuum theory of grain size evolution and damage

NASA Astrophysics Data System (ADS)

Ricard, Y.; Bercovici, D.

2009-01-01

Lithospheric shear localization, as occurs in the formation of tectonic plate boundaries, is often associated with diminished grain size (e.g., mylonites). Grain size reduction is typically attributed to dynamic recrystallization; however, theoretical models of shear localization arising from this hypothesis are problematic because (1) they require the simultaneous action of two creep mechanisms (diffusion and dislocation creep) that occur in different deformation regimes (i.e., in grain size stress space) and (2) the grain growth ("healing") laws employed by these models are derived from normal grain growth or coarsening theory, which are valid in the absence of deformation, although the shear localization setting itself requires deformation. Here we present a new first principles grained-continuum theory, which accounts for both coarsening and damage-induced grain size reduction in a monomineralic assemblage undergoing irrecoverable deformation. Damage per se is the generic process for generation of microcracks, defects, dislocations (including recrystallization), subgrains, nuclei, and cataclastic breakdown of grains. The theory contains coupled macroscopic continuum mechanical and grain-scale statistical components. The continuum level of the theory considers standard mass, momentum, and energy conservation, as well as entropy production, on a statistically averaged grained continuum. The grain-scale element of the theory describes both the evolution of the grain size distribution and mechanisms for both continuous grain growth and discontinuous grain fracture and coalescence. The continuous and discontinuous processes of grain size variation are prescribed by nonequilibrium thermodynamics (in particular, the treatment of entropy production provides the phenomenological laws for grain growth and reduction); grain size evolution thus incorporates the free energy differences between grains, including both grain boundary surface energy (which controls coarsening) and the contribution of deformational work to these free energies (which controls damage). In the absence of deformation, only two mechanisms that increase the average grain size are allowed by the second law of thermodynamics. One mechanism, involving continuous diffusive mass transport from small to large grains, captures the essential components of normal grain growth theories of Lifshitz-Slyosov and Hillert. The second mechanism involves the aggregation of grains and is described using a Smoluchovski formalism. With the inclusion of deformational work and damage, the theory predicts two mechanisms for which the thermodynamic requirement of entropy positivity always forces large grains to shrink and small ones to grow. The first such damage-driven mechanism involving continuous mass transfer from large to small grains tends to homogenize the distribution of grain size toward its initial mean grain size. The second damage mechanism favors the creation of small grains by discontinuous division of larger grains and reduces the mean grain size with time. When considered separately, most of these mechanisms allow for self-similar grain size distributions whose scales (i.e., statistical moments such as the mean, variance, and skewness) can all be described by a single grain scale, such as the mean or maximum. However, the combination of mechanisms, e.g., one that captures the competition between continuous coarsening and mean grain size reduction by breakage, does not generally permit a self-similar solution for the grain size distribution, which contradicts the classic assumption that grain growth laws allowing for both coarsening and recrystallization can be treated with a single grain scale such as the mean size.

New Genes and New Insights from Old Genes: Update on Alzheimer Disease

PubMed Central

Ringman, John M.; Coppola, Giovanni

2013-01-01

Purpose of Review: This article discusses the current status of knowledge regarding the genetic basis of Alzheimer disease (AD) with a focus on clinically relevant aspects. Recent Findings: The genetic architecture of AD is complex, as it includes multiple susceptibility genes and likely nongenetic factors. Rare but highly penetrant autosomal dominant mutations explain a small minority of the cases but have allowed tremendous advances in understanding disease pathogenesis. The identification of a strong genetic risk factor, APOE, reshaped the field and introduced the notion of genetic risk for AD. More recently, large-scale genome-wide association studies are adding to the picture a number of common variants with very small effect sizes. Large-scale resequencing studies are expected to identify additional risk factors, including rare susceptibility variants and structural variation. Summary: Genetic assessment is currently of limited utility in clinical practice because of the low frequency (Mendelian mutations) or small effect size (common risk factors) of the currently known susceptibility genes. However, genetic studies are identifying with confidence a number of novel risk genes, and this will further our understanding of disease biology and possibly the identification of therapeutic targets. PMID:23558482

Mechanisms behind overshoots in mean cluster size profiles in aggregation-breakup processes.

PubMed

Sadegh-Vaziri, Ramiar; Ludwig, Kristin; Sundmacher, Kai; Babler, Matthaus U

2018-05-26

Aggregation and breakup of small particles in stirred suspensions often shows an overshoot in the time evolution of the mean cluster size: Starting from a suspension of primary particles the mean cluster size first increases before going through a maximum beyond which a slow relaxation sets in. Such behavior was observed in various systems, including polymeric latices, inorganic colloids, asphaltenes, proteins, and, as shown by independent experiments in this work, in the flocculation of microalgae. This work aims at investigating possible mechanism to explain this phenomenon using detailed population balance modeling that incorporates refined rate models for aggregation and breakup of small particles in turbulence. Four mechanisms are considered: (1) restructuring, (2) decay of aggregate strength, (3) deposition of large clusters, and (4) primary particle aggregation where only aggregation events between clusters and primary particles are permitted. We show that all four mechanisms can lead to an overshoot in the mean size profile, while in contrast, aggregation and breakup alone lead to a monotonic, "S"-shaped size evolution profile. In order to distinguish between the different mechanisms simple protocols based on variations of the shear rate during the aggregation-breakup process are proposed. Copyright © 2018 Elsevier Inc. All rights reserved.

Social Networks as a Source of Competitive Advantage for the Firm.

ERIC Educational Resources Information Center

Van Laere, Kristien; Heene, Aime

2003-01-01

Proposes a conceptual framework for managing relationships of small and medium-sized enterprises, based on the necessity of cooperation for survival. Describes characteristics of embedded relationship in stakeholder interactions, including trust, durability, information transfer, and collaboration. (Contains 72 references.) (SK)

77 FR 51759 - U.S. Medical Mission to Brazil; Sao Paulo, Brazil, May 21-24, 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... for small and medium-sized enterprises (SME) \\1\\ and $5475 for large companies. This includes entry... will be the responsibility of each mission participant. \\1\\ An SME is defined as a firm with 500 or...

RESIDENTIAL INDOOR EXPOSURES OF CHILDREN TO PESTICIDES FOLLOWING LAWN APPLICATIONS

EPA Science Inventory

Methods have been developed to estimate children's residential exposures to pesticide residues and applied in a small field study of indoor exposures resulting from the intrusion of lawn-applied herbicide into the home. Sampling methods included size-selective indoor air sampli...

78 FR 42817 - Small Business Size Standards: Waiver of the Nonmanufacturer Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... SMALL BUSINESS ADMINISTRATION Small Business Size Standards: Waiver of the Nonmanufacturer Rule AGENCY: U.S. Small Business Administration. ACTION: Notice of intent to rescind the class waiver of the... Manufacturing. SUMMARY: The U. S. Small Business Administration (SBA) intends to rescind a class waiver of the...

Finite-size effects in Anderson localization of one-dimensional Bose-Einstein condensates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cestari, J. C. C.; Foerster, A.; Gusmao, M. A.

We investigate the disorder-induced localization transition in Bose-Einstein condensates for the Anderson and Aubry-Andre models in the noninteracting limit using exact diagonalization. We show that, in addition to the standard superfluid fraction, other tools such as the entanglement and fidelity can provide clear signatures of the transition. Interestingly, the fidelity exhibits good sensitivity even for small lattices. Effects of the system size on these quantities are analyzed in detail, including the determination of a finite-size-scaling law for the critical disorder strength in the case of the Anderson model.

A new design of facial artery perforator flaps for the reconstruction of small- to medium-sized intraoral defects.

PubMed

Du, Yi-fei; Zhou, Wei-na; Li, Jie; Jiang, Hong-bing; Yuan, Hua; Wan, Lin-zhong

2014-11-01

The aim of this study was to investigate the reliability and outcomes of a new design of facial artery perforator flaps, extending from the angle of the mouth to the border of the mandible, for the reconstruction of small- to medium-sized intraoral defects. The technique had been used in 23 patients between February 2009 and August 2012. The locations of intraoral defects included the tongue, the floor of the mouth, the inferior gingival mucosa, and the sublingual gland. All flaps were monitored for complications including skin loss and ischemia. The functions of appearance, swallowing, and speech were assessed 6 months after operation with the University of Washington Quality of Life Questionnaire. All flaps presented with satisfactory results except for one, which demonstrated superficial tip necrosis that settled after conservative treatment. The follow-up period ranged from 6 to 12 months, and 1 patient died as a result of pulmonary metastasis, and 3 patients underwent second surgery because of local tumor recurrence (2patients) and cervical recurrence (1 patient). Nineteen patients were assessed with the University of Washington Quality of Life Questionnaire, and the mean (SD) scores of appearance, swallowing, and speech were 57.89 (14.45), 83.68 (19.98), and 81.58 (23.16), respectively. This design of facial artery perforator flaps could provide an efficient and cost-effective method for reconstruction of small- to medium-sized intraoral defects with a low surgical morbidity and satisfactory levels of quality of life.

Temperate Earth-sized planets transiting a nearby ultracool dwarf star

NASA Astrophysics Data System (ADS)

Gillon, Michaël; Jehin, Emmanuël; Lederer, Susan M.; Delrez, Laetitia; de Wit, Julien; Burdanov, Artem; Van Grootel, Valérie; Burgasser, Adam J.; Triaud, Amaury H. M. J.; Opitom, Cyrielle; Demory, Brice-Olivier; Sahu, Devendra K.; Bardalez Gagliuffi, Daniella; Magain, Pierre; Queloz, Didier

2016-05-01

Star-like objects with effective temperatures of less than 2,700 kelvin are referred to as ‘ultracool dwarfs’. This heterogeneous group includes stars of extremely low mass as well as brown dwarfs (substellar objects not massive enough to sustain hydrogen fusion), and represents about 15 per cent of the population of astronomical objects near the Sun. Core-accretion theory predicts that, given the small masses of these ultracool dwarfs, and the small sizes of their protoplanetary disks, there should be a large but hitherto undetected population of terrestrial planets orbiting them—ranging from metal-rich Mercury-sized planets to more hospitable volatile-rich Earth-sized planets. Here we report observations of three short-period Earth-sized planets transiting an ultracool dwarf star only 12 parsecs away. The inner two planets receive four times and two times the irradiation of Earth, respectively, placing them close to the inner edge of the habitable zone of the star. Our data suggest that 11 orbits remain possible for the third planet, the most likely resulting in irradiation significantly less than that received by Earth. The infrared brightness of the host star, combined with its Jupiter-like size, offers the possibility of thoroughly characterizing the components of this nearby planetary system.

Factors associated with long-term species composition in dry tropical forests of Central India

NASA Astrophysics Data System (ADS)

Agarwala, M.; DeFries, R. S.; Qureshi, Q.; Jhala, Y. V.

2016-10-01

The long-term future of species composition in forests depends on regeneration. Many factors can affect regeneration, including human use, environmental conditions, and species’ traits. This study examines the influence of these factors in a tropical deciduous forest of Central India, which is heavily used by local, forest-dependent residents for livestock grazing, fuel-wood extraction, construction and other livelihood needs. We measure size-class proportions (the ratio of abundance of a species at a site in a higher size class to total abundance in both lower and higher size classes) for 39 tree species across 20 transects at different intensities of human use. The size-class proportions for medium to large trees and for small to medium-sized trees were negatively associated with species that are used for local construction, while size class proportions for saplings to small trees were positively associated with those species that are fire resistant and negatively associated with livestock density. Results indicate that grazing and fire prevent non-fire resistant species from reaching reproductive age, which can alter the long term composition and future availability of species that are important for local use and ecosystem services. Management efforts to reduce fire and forest grazing could reverse these impacts on long-term forest composition.

Ferroelectric properties of composites containing BaTiO 3 nanoparticles of various sizes

NASA Astrophysics Data System (ADS)

Adam, Jens; Lehnert, Tobias; Klein, Gabi; McMeeking, Robert M.

2014-01-01

Size effects, including the occurrence of superparaelectric phases associated with small scale, are a significant research topic for ferroelectrics. Relevant phenomena have been explored in detail, e.g. for homogeneous, thin ferroelectric films, but the related effects associated with nanoparticles are usually only inferred from their structural properties. In contrast, this paper describes all the steps and concepts necessary for the direct characterization and quantitative assessment of the ferroelectric properties of as-synthesized and as-received nanoparticles. The method adopted uses electrical polarization measurements on polymer matrix composites containing ferroelectric nanoparticles. It is applied to ten different BaTiO3 particle types covering a size range from 10 nm to 0.8 μm. The influence of variations of particle characteristics such as tetragonality and dielectric constant is considered based on measurements of these properties. For composites containing different particle types a clearly differing polarization behaviour is found. For decreasing particle size, increasing electric field is required to achieve a given level of polarization. The size dependence of a measure related to the coercive field revealed by this work is qualitatively in line with the state of the knowledge for ferroelectrics having small dimensions. For the first time, such results and size effects are described based on data from experiments on collections of actual nanoparticles.

Temperate Earth-sized planets transiting a nearby ultracool dwarf star.

PubMed

Gillon, Michaël; Jehin, Emmanuël; Lederer, Susan M; Delrez, Laetitia; de Wit, Julien; Burdanov, Artem; Van Grootel, Valérie; Burgasser, Adam J; Triaud, Amaury H M J; Opitom, Cyrielle; Demory, Brice-Olivier; Sahu, Devendra K; Bardalez Gagliuffi, Daniella; Magain, Pierre; Queloz, Didier

2016-05-12

Star-like objects with effective temperatures of less than 2,700 kelvin are referred to as 'ultracool dwarfs'. This heterogeneous group includes stars of extremely low mass as well as brown dwarfs (substellar objects not massive enough to sustain hydrogen fusion), and represents about 15 per cent of the population of astronomical objects near the Sun. Core-accretion theory predicts that, given the small masses of these ultracool dwarfs, and the small sizes of their protoplanetary disks, there should be a large but hitherto undetected population of terrestrial planets orbiting them--ranging from metal-rich Mercury-sized planets to more hospitable volatile-rich Earth-sized planets. Here we report observations of three short-period Earth-sized planets transiting an ultracool dwarf star only 12 parsecs away. The inner two planets receive four times and two times the irradiation of Earth, respectively, placing them close to the inner edge of the habitable zone of the star. Our data suggest that 11 orbits remain possible for the third planet, the most likely resulting in irradiation significantly less than that received by Earth. The infrared brightness of the host star, combined with its Jupiter-like size, offers the possibility of thoroughly characterizing the components of this nearby planetary system.

Assessment of management and basic beef quality assurance practices on Idaho dairies.

PubMed

Glaze, J B; Chahine, M

2009-03-01

In 2004 a mail-in survey was conducted to establish a baseline level of awareness and knowledge related to dairy beef quality assurance (BQA) issues in Idaho. A 30-question survey was mailed to every (n = 736) registered Idaho dairy. Two-hundred seventy-three (37%) dairies participated and were categorized as small (n <201 cows; 53.5%), medium-sized (n = 201 to 1,000 cows; 27.1%) or large (n >1,000 cows; 19.4%). The majority of respondents were dairy owners (83%). Eighty-nine percent of respondents indicated they followed BQA recommendations for animal care. The neck region in cows was used by 68% of respondents for i.m. injections and by 80% for s.c. injections. In calves, the values were 61 and 78%, respectively. Seventy-four percent of respondents indicated they had been trained for injections. Training methods cited included veterinarians (19.8%), dairy owners (16.8%), experience (9.9%), and BQA events or schools (4.5%). The importance of BQA in the dairy industry was rated 2.6 on a 5-point scale (0 = low; 4 = high). Participants rated the effect of dairy animals on the beef industry at 2.5. Plastic ear tags were the preferred method of animal identification, with 100% of large dairies, 97.3% of medium-sized dairies, and 84% of small dairies citing their use. Less than 10% used electronic identification for their animals. Almost half (48%) of large and medium-sized (49%) dairies and 32% of small dairies supported a national animal identification program. A mandatory identification program was supported by 41, 69, and 59% for small, medium-sized, and large dairies, respectively. The percentage of dairies keeping records was similar between small (93%), medium-sized (99%), and large (100%) dairies. Most small dairies (58%) used some form of paper records, whereas most medium-sized (85%) and large (100%) dairies used computers for record keeping. The preferred method to market cull cows by Idaho dairies was the auction market (64%), followed by order buyers (17%), direct to the packer (17%), private treaty sales (16%), and forward contracts (1%). To market calves, dairies used private treaty sales (52%), auction markets (42%), order buyers (14%), and forward contracts (1%). The results of this study will be used by University of Idaho Extension faculty in the design, development, and delivery of dairy BQA program information and materials.

77 FR 20688 - Seventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

... Committee 225, Rechargeable Lithium Batteries and Battery Systems, Small and Medium Size AGENCY: Federal... Committee 225, Rechargeable Lithium Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA..., Rechargeable Lithium Batteries and Battery Systems, Small and Medium Size. DATES: The meeting will be held May...

Nanoscale effects of silica particle supports on the formation and properties of TiO2 nanocatalysts

NASA Astrophysics Data System (ADS)

Li, Aize; Jin, Yuhui; Muggli, Darrin; Pierce, David T.; Aranwela, Hemantha; Marasinghe, Gaya K.; Knutson, Theodore; Brockman, Greg; Zhao, Julia Xiaojun

2013-06-01

Small TiO2 crystals in the anatase phase are in high demand as photocatalysts. Stable TiO2 crystals in the anatase phase were obtained using a silica nanoparticle as a support. The focus of this study was to investigate the nanoscale effect of the silica support on the formation and properties of small anatase crystals. The experiments were carried out using powder X-ray diffraction, differential thermal analysis, transmission electron microscopy, and energy dispersion spectroscopy. The results showed that the size of the silica support played a crucial role in crystallization of TiO2 and regulation of TiO2 properties, including phase transition, crystal size, thermodynamic property and catalytic activity. A nanoscale curvature model of the spherical silica support was proposed to explain these size effects. Finally, the developed TiO2 catalysts were applied to the oxidation of methanol using a high-throughput photochemical reactor. The size effect of the silica supports on the TiO2 catalytic efficiency was demonstrated using this system.

An abundance of small exoplanets around stars with a wide range of metallicities.

PubMed

Buchhave, Lars A; Latham, David W; Johansen, Anders; Bizzarro, Martin; Torres, Guillermo; Rowe, Jason F; Batalha, Natalie M; Borucki, William J; Brugamyer, Erik; Caldwell, Caroline; Bryson, Stephen T; Ciardi, David R; Cochran, William D; Endl, Michael; Esquerdo, Gilbert A; Ford, Eric B; Geary, John C; Gilliland, Ronald L; Hansen, Terese; Isaacson, Howard; Laird, John B; Lucas, Philip W; Marcy, Geoffrey W; Morse, Jon A; Robertson, Paul; Shporer, Avi; Stefanik, Robert P; Still, Martin; Quinn, Samuel N

2012-06-13

The abundance of heavy elements (metallicity) in the photospheres of stars similar to the Sun provides a 'fossil' record of the chemical composition of the initial protoplanetary disk. Metal-rich stars are much more likely to harbour gas giant planets, supporting the model that planets form by accumulation of dust and ice particles. Recent ground-based surveys suggest that this correlation is weakened for Neptunian-sized planets. However, how the relationship between size and metallicity extends into the regime of terrestrial-sized exoplanets is unknown. Here we report spectroscopic metallicities of the host stars of 226 small exoplanet candidates discovered by NASA's Kepler mission, including objects that are comparable in size to the terrestrial planets in the Solar System. We find that planets with radii less than four Earth radii form around host stars with a wide range of metallicities (but on average a metallicity close to that of the Sun), whereas large planets preferentially form around stars with higher metallicities. This observation suggests that terrestrial planets may be widespread in the disk of the Galaxy, with no special requirement of enhanced metallicity for their formation.

Group size, individual role differentiation and effectiveness of cooperation in a homogeneous group of hunters

PubMed Central

Escobedo, R.; Muro, C.; Spector, L.; Coppinger, R. P.

2014-01-01

The emergence of cooperation in wolf-pack hunting is studied using a simple, homogeneous, particle-based computational model. Wolves and prey are modelled as particles that interact through attractive and repulsive forces. Realistic patterns of wolf aggregation readily emerge in numerical simulations, even though the model includes no explicit wolf–wolf attractive forces, showing that the form of cooperation needed for wolf-pack hunting can take place even among strangers. Simulations are used to obtain the stationary states and equilibria of the wolves and prey system and to characterize their stability. Different geometric configurations for different pack sizes arise. In small packs, the stable configuration is a regular polygon centred on the prey, while in large packs, individual behavioural differentiation occurs and induces the emergence of complex behavioural patterns between privileged positions. Stable configurations of large wolf-packs include travelling and rotating formations, periodic oscillatory behaviours and chaotic group behaviours. These findings suggest a possible mechanism by which larger pack sizes can trigger collective behaviours that lead to the reduction and loss of group hunting effectiveness, thus explaining the observed tendency of hunting success to peak at small pack sizes. They also explain how seemingly complex collective behaviours can emerge from simple rules, among agents that need not have significant cognitive skills or social organization. PMID:24694897

Sex differences in relative foot length and perceived attractiveness of female feet: relationships among anthropometry, physique, and preference ratings.

PubMed

Voracek, Martin; Fisher, Maryanne L; Rupp, Barbara; Lucas, Deanna; Fessler, Daniel M T

2007-06-01

Foot size proportionate to stature is smaller in women than in men, and small feet apparently contribute to perceived physical attractiveness of females. This exploratory study investigated the sex difference in relative foot length and interrelations among foot length, physique, and foot preference ratings in samples from Austria and Canada, each comprised of 75 men and 75 women. The findings included the following lines of evidence: the sex difference in relative foot length replicated in both data sets; the magnitude of this sex effect was large. Relative foot length was smaller in young, nulliparous, and slim women. Pointed-toe and high-heel shoes were more likely worn by smaller, lighter, and slimmer women. Men reported liking women's feet in general more than vice versa. A vast majority of both men and women favored small feet in women, but large feet in men. One's own foot size appeared to correspond to evaluations of attractiveness; particularly, women with small feet preferred small feet in women in general. The preference for small feet in women was convergent across different methods of evaluating attractiveness. Directions for investigations in this emerging field of research on physical attractiveness are discussed.

Infrared Space Astrometry Missions ˜ JASMINE Missions ˜

NASA Astrophysics Data System (ADS)

Gouda, N.

2012-08-01

"JASMINE" is an abbreviation of Japan Astrometry Satellite Mission for Infrared Exploration. Three satellites are planned as a series of JASMINE missions, as a step-by-step approach, to overcome technical issues and promote scientific results. These are Nano-JASMINE, Small-JASMINE and (medium-sized) JASMINE. JASMINE missions provide the positions and proper motions of celestial objects. Nano-JASMINE uses a very small nano-satellite and is scheduled to be launched in 2013. Nano-JASMINE will operate in zw-band (˜ 0.8μm) to perform an all sky survey with an accuracy of 3 milli-arcseconds for position and parallaxes. Small-JASMINE will observe towards a region around the Galactic center and other small regions, which include interesting scientific targets, with accuracies of 10 to 50 μ-arcseconds in an infrared Hw-band (˜ 1.7 μm). The target launch date is around 2017. (Medium-sized) JASMINE is an extended mission of Small-JASMINE, which will observe towards almost the whole region of the Galactic bulge with accuracies of ˜ 10 μ arcseconds in Kw-band (˜ 2.0μ m). The target launch date is the first half of the 2020s.

Power and money in cluster randomized trials: when is it worth measuring a covariate?

PubMed

Moerbeek, Mirjam

2006-08-15

The power to detect a treatment effect in cluster randomized trials can be increased by increasing the number of clusters. An alternative is to include covariates into the regression model that relates treatment condition to outcome. In this paper, formulae are derived in order to evaluate both strategies on basis of their costs. It is shown that the strategy that uses covariates is more cost-efficient in detecting a treatment effect when the costs to measure these covariates are small and the correlation between the covariates and outcome is sufficiently large. The minimum required correlation depends on the cluster size, and the costs to recruit a cluster and to measure the covariate, relative to the costs to recruit a person. Measuring a covariate that varies at the person level only is recommended when cluster sizes are small and the costs to recruit and measure a cluster are large. Measuring a cluster level covariate is recommended when cluster sizes are large and the costs to recruit and measure a cluster are small. An illustrative example shows the use of the formulae in a practical setting. Copyright 2006 John Wiley & Sons, Ltd.

13 CFR 121.804 - When does SBA determine the size status of a business concern?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When does SBA determine the size status of a business concern? 121.804 Section 121.804 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size Eligibility...

13 CFR 121.504 - When does SBA determine the size status of a business concern?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When does SBA determine the size status of a business concern? 121.504 Section 121.504 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size Eligibility...

13 CFR 121.304 - What are the size requirements for refinancing an existing SBA loan?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the size requirements for refinancing an existing SBA loan? 121.304 Section 121.304 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size Eligibility...

Laparoscopic resection of gastric and small bowel gastrointestinal stromal tumors: 10-year experience at a single center.

PubMed

Tabrizian, Parissa; Sweeney, Robert E; Uhr, Joshua H; Nguyen, Scott Q; Divino, Celia M

2014-03-01

Complete curative resection remains the treatment of choice for nonmetastatic gastrointestinal stromal tumors (GISTs). The safety and feasibility of laparoscopy in the treatment of this disease has been shown, however, the long-term oncologic outcomes of this technique remain unclear. An ongoing prospectively maintained database including all laparoscopically resected gastric and small bowel GISTs (n = 116) at Mount Sinai Medical Center from July 1999 to December 2011 was retrospectively analyzed. Recurrence and survival outcomes were calculated using the Kaplan-Meier method and compared with log-rank test. Tumors were of gastric (77.6%) and small bowel (22.4%) origins. Overall mean tumor size was 4.0 cm (±2.7 cm) and R0 resection was achieved in 113 (97.4%) cases. Overall perioperative complication rate was 14.7%, with a reoperative rate of 4.3% at 90 days. When comparing gastric with small bowel GISTs, a more acute presentation requiring emergent resections was noted in patients with small bowel GISTs (p = 008). However tumor size, operative data, and perioperative outcomes were comparable in both groups (p = NS). At a median follow-up of 56.4 months (range 0.1 to 162.4 months), recurrence rate was 7.8% and comparable in both gastric and small bowel GISTs (p = NS). Risk factors for recurrence on univariate analysis were presence of ulceration/necrosis (p < 0.001) and tumor size >5 cm (p = 0.05). Overall 10-year survival rate was 90.8%. Gastric and small bowel overall survival rates were similar (90.7% vs 91.3%, respectively). Overall 10-year disease-free survival was 80.0% (84.3% gastric vs 71.6% small bowel; p = NS). Our series demonstrates the safety and feasibility of laparoscopy in patients undergoing resection of small bowel and gastric GISTs. Comparable long-term oncologic outcomes with a 10-year survival of 90.8% were achieved. Copyright © 2014. Published by Elsevier Inc.

Food-web structure and network theory: The role of connectance and size

PubMed Central

Dunne, Jennifer A.; Williams, Richard J.; Martinez, Neo D.

2002-01-01

Networks from a wide range of physical, biological, and social systems have been recently described as “small-world” and “scale-free.” However, studies disagree whether ecological networks called food webs possess the characteristic path lengths, clustering coefficients, and degree distributions required for membership in these classes of networks. Our analysis suggests that the disagreements are based on selective use of relatively few food webs, as well as analytical decisions that obscure important variability in the data. We analyze a broad range of 16 high-quality food webs, with 25–172 nodes, from a variety of aquatic and terrestrial ecosystems. Food webs generally have much higher complexity, measured as connectance (the fraction of all possible links that are realized in a network), and much smaller size than other networks studied, which have important implications for network topology. Our results resolve prior conflicts by demonstrating that although some food webs have small-world and scale-free structure, most do not if they exceed a relatively low level of connectance. Although food-web degree distributions do not display a universal functional form, observed distributions are systematically related to network connectance and size. Also, although food webs often lack small-world structure because of low clustering, we identify a continuum of real-world networks including food webs whose ratios of observed to random clustering coefficients increase as a power–law function of network size over 7 orders of magnitude. Although food webs are generally not small-world, scale-free networks, food-web topology is consistent with patterns found within those classes of networks. PMID:12235364

Fracture Test Methods for Plastically Responding COPV Liners

NASA Technical Reports Server (NTRS)

Dawicke, David S.; Lewis, Joseph C.

2009-01-01

An experimental procedure for evaluating the validity of using uniaxial tests to provide a conservative bound on the fatigue crack growth rate behavior small cracks in bi-axially loaded Composite Overwrapped Pressure Vessel (COPV) liners is described. The experimental procedure included the use of a laser notch to quickly generate small surface fatigue cracks with the desired size and aspect ratios. An out-of-plane constraint system was designed to allow fully reversed, fully plastic testing of thin sheet uniaxial coupons. Finally, a method was developed to determine to initiate small cracks in the liner of COPVs.

ELROI Extremely Low Resource Optical Identifier. A license plate for your satellite, and more.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palmer, David

ELROI (Extremely Low Resource Optical Identifier) is a license plate for your satellite; a small tag that flashes an optical identification code that can be read by a small telescope on the ground. The final version of the tag will be the size of a thick postage stamp and fully autonomous: you can attach it to everything that goes into space, including small cubesats and inert debris like rocket stages, and it will keep blinking even after the satellite is shut down, reliably identifying the object from launch until re-entry.

For the depolarization of linearly polarized light by smoke particles

NASA Astrophysics Data System (ADS)

Sun, Wenbo; Liu, Zhaoyan; Videen, Gorden; Fu, Qiang; Muinonen, Karri; Winker, David M.; Lukashin, Constantine; Jin, Zhonghai; Lin, Bing; Huang, Jianping

2013-06-01

The CALIPSO satellite mission consistently measures volume (including molecule and particulate) light depolarization ratio of ∼2% for smoke, compared to ∼1% for marine aerosols and ∼15% for dust. The observed ∼2% smoke depolarization ratio comes primarily from the nonspherical habits of particles in the smoke at certain particle sizes. In this study, the depolarization of linearly polarized light by small sphere aggregates and irregular Gaussian-shaped particles is studied, to reveal the physics between the depolarization of linearly polarized light and smoke aerosol shape and size. It is found that the depolarization ratio curves of Gaussian-deformed spheres are very similar to sphere aggregates in terms of scattering-angle dependence and particle size parameters when particle size parameter is smaller than 1.0π. This demonstrates that small randomly oriented nonspherical particles have some common depolarization properties as functions of scattering angle and size parameter. This may be very useful information for characterization and active remote sensing of smoke particles using polarized light. We also show that the depolarization ratio from the CALIPSO measurements could be used to derive smoke aerosol particle size. From the calculation results for light depolarization ratio by Gaussian-shaped smoke particles and the CALIPSO-measured light depolarization ratio of ∼2% for smoke, the mean particle size of South-African smoke is estimated to be about half of the 532nm wavelength of the CALIPSO lidar.

Organic-aqueous crossover coating process for the desmopressin orally disintegrating microparticles.

PubMed

Kim, Ju-Young; Hwang, Kyu-Mok; Park, Chun-Woong; Rhee, Yun-Seok; Park, Eun-Seok

2015-02-01

The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert cores and a coating material, respectively. Characterizations including size distribution analysis, in-vitro release studies and in-vitro disintegration studies were performed. A pharmacokinetic study of the ODMs was also conducted in eight beagle dogs. It was found that sucrose beads should be coated using organic solvents to preserve their original morphology. For the active coating, the aqueous coating solution should be used for drug stability. When sucrose beads were coated using organic-aqueous crossover coating process, double-layer ODMs with round shapes were produced with detectable impurities below limit of US Pharmacopeia. The median size of ODMs was 195.6 μm, which was considered small enough for a good mouthfeel. The ODMs dissolved in artificial saliva within 15 s because of hydrophilic materials including sucrose and HPC in the ODMs. Because of its fast-dissolving properties, 100% release of the drug was reached within 5 min. Pharmacokinetic parameters including Cmax and AUC24 indicated bioequivalence of the ODMs and the conventional immediate release tablets. Therefore, by using the organic-aqueous crossover coating process, double-layer ODMs were successively prepared with small size, round shapes and good drug stability.

IMPROVING HYDROLOGIC SUSTAINABILITY OF TEXAS A&M UNIVERSITY CAMPUS

EPA Science Inventory

For small to mid-sized rain events, LID scenarios, including permeable pavements, rainwater harvesting, green roofs, and riparian buffer strips perform similarly to a conventional Best Management Practice, a detention pond, with respect to peak flows and HFR. For large rain ev...

Habitat size modulates the influence of heterogeneity on species richness patterns in a model zooplankton community.

PubMed

Schuler, Matthew S; Chase, Jonathan M; Knight, Tiffany M

2017-06-01

Habitat heterogeneity is a primary mechanism influencing species richness. Despite the general expectation that increased heterogeneity should increase species richness, there is considerable variation in the observed relationship, including many studies that show negative effects of heterogeneity on species richness. One mechanism that can create such disparate results is the predicted trade-off between habitat area and heterogeneity, sometimes called the area-heterogeneity-trade-off (AHTO) hypothesis. The AHTO hypothesis predicts positive effects of heterogeneity on species richness in large habitats, but negative effects in small habitats. We examined the interplay between habitat size and habitat heterogeneity in experimental mesocosms that mimic freshwater ponds, and measured responses in a species-rich zooplankton community. We used the AHTO hypothesis and related mechanisms to make predictions about how heterogeneity would affect species richness and diversity in large compared to small habitats. We found that heterogeneity had a positive influence on species richness in large, but not small habitats, and that this likely resulted because habitat specialists were able to persist only when habitat size was sufficiently large, consistent with the predictions of the AHTO hypothesis. Our results emphasize the importance of considering context (e.g., habitat size in this case) when investigating the relative importance of ecological drivers of diversity, like heterogeneity. © 2017 by the Ecological Society of America.

Using the Student's "t"-Test with Extremely Small Sample Sizes

ERIC Educational Resources Information Center

de Winter, J. C .F.

2013-01-01

Researchers occasionally have to work with an extremely small sample size, defined herein as "N" less than or equal to 5. Some methodologists have cautioned against using the "t"-test when the sample size is extremely small, whereas others have suggested that using the "t"-test is feasible in such a case. The present…

Tract Sizes in Miniaturized Percutaneous Nephrolithotomy: A Systematic Review from the European Association of Urology Urolithiasis Guidelines Panel.

PubMed

Ruhayel, Yasir; Tepeler, Abdulkadir; Dabestani, Saeed; MacLennan, Steven; Petřík, Aleš; Sarica, Kemal; Seitz, Christian; Skolarikos, Andreas; Straub, Michael; Türk, Christian; Yuan, Yuhong; Knoll, Thomas

2017-08-01

Miniaturized instruments for percutaneous nephrolithotomy (PNL), utilizing tracts sized ≤22 Fr, have been developed in an effort to reduce the morbidity and increase the efficiency of stone removal compared with standard PNL (>22 Fr). We systematically reviewed all available evidence on the efficacy and safety of miniaturized PNL for removing renal calculi. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Since it was not possible to perform a meta-analysis, the data were summarized in a narrative synthesis. After screening 2945 abstracts, 18 studies were included (two randomized controlled trials [RCTs], six nonrandomized comparative studies, and 10 case series). Thirteen studies were full-text articles and five were only available as congress abstracts. The size of tracts used in miniaturized procedures ranged from 22 Fr to 4.8 Fr. The largest mean stone size treated using small instruments was 980mm 2 . Stone-free rates were comparable in miniaturized and standard PNL procedures. Procedures performed with small instruments tended to be associated with significantly lower blood loss, while the procedure duration tended to be significantly longer. Other complications were not notably different between PNL types. Study designs and populations were heterogeneous. Study limitations included selection and outcome reporting bias, as well as a lack of information on relevant confounding factors. The studies suggest that miniaturized PNL is at least as efficacious and safe as standard PNL for the removal of renal calculi. However, the quality of the evidence was poor, drawn mainly from small studies, the majority of which were single-arm case series, and only two of which were RCTs. Furthermore, the tract sizes used and types of stones treated were heterogeneous. Hence, the risks of bias and confounding were high, highlighting the need for more reliable data from RCTs. Removing kidney stones via percutaneous nephrolithotomy (PNL) using smaller sized instruments (mini-PNL) appears to be as effective and safe as using larger (traditional) instruments, but more clinical research is needed. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Small-business employment in 22 rich economies.

PubMed

Schmitt, John; Lane, Nathan

2010-01-01

Opponents of health care reform in the United States have often argued that such reform will be detrimental to small and medium-sized enterprises. The authors review the most recent data from a sample of 22 rich countries in the Organization for Economic Cooperation and Development (OECD), all of which, except the United States, have universal health care systems. By every measure of small-business employment, the United States has among the world's smallest small-business sectors (as a proportion of total national employment). These findings hold for self-employed workers and across all industry groups for which the Paris-based OECD publishes internationally comparable data, including manufacturing, computer-related services, and research and development.

13 CFR 121.509 - What is the size standard for leasing of Government land for coal mining?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What is the size standard for leasing of Government land for coal mining? 121.509 Section 121.509 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Size...

Physiological Benefits of Being Small in a Changing World: Responses of Coho Salmon (Oncorhynchus kisutch) to an Acute Thermal Challenge and a Simulated Capture Event

PubMed Central

Clark, Timothy D.; Donaldson, Michael R.; Pieperhoff, Sebastian; Drenner, S. Matthew; Lotto, Andrew; Cooke, Steven J.; Hinch, Scott G.; Patterson, David A.; Farrell, Anthony P.

2012-01-01

Evidence is building to suggest that both chronic and acute warm temperature exposure, as well as other anthropogenic perturbations, may select for small adult fish within a species. To shed light on this phenomenon, we investigated physiological and anatomical attributes associated with size-specific responses to an acute thermal challenge and a fisheries capture simulation (exercise+air exposure) in maturing male coho salmon (Oncorhynchus kisutch). Full-size females were included for a sex-specific comparison. A size-specific response in haematology to an acute thermal challenge (from 7 to 20°C at 3°C h−1) was apparent only for plasma potassium, whereby full-size males exhibited a significant increase in comparison with smaller males (‘jacks’). Full-size females exhibited an elevated blood stress response in comparison with full-size males. Metabolic recovery following exhaustive exercise at 7°C was size-specific, with jacks regaining resting levels of metabolism at 9.3±0.5 h post-exercise in comparison with 12.3±0.4 h for full-size fish of both sexes. Excess post-exercise oxygen consumption scaled with body mass in male fish with an exponent of b = 1.20±0.08. Jacks appeared to regain osmoregulatory homeostasis faster than full-size males, and they had higher ventilation rates at 1 h post-exercise. Peak metabolic rate during post-exercise recovery scaled with body mass with an exponent of b∼1, suggesting that the slower metabolic recovery in large fish was not due to limitations in diffusive or convective oxygen transport, but that large fish simply accumulated a greater ‘oxygen debt’ that took longer to pay back at the size-independent peak metabolic rate of ∼6 mg min−1 kg−1. Post-exercise recovery of plasma testosterone was faster in jacks compared with full-size males, suggesting less impairment of the maturation trajectory of smaller fish. Supporting previous studies, these findings suggest that environmental change and non-lethal fisheries interactions have the potential to select for small individuals within fish populations over time. PMID:22720035

Does group size have an impact on welfare indicators in fattening pigs?

PubMed

Meyer-Hamme, S E K; Lambertz, C; Gauly, M

2016-01-01

Production systems for fattening pigs have been characterized over the last 2 decades by rising farm sizes coupled with increasing group sizes. These developments resulted in a serious public discussion regarding animal welfare and health in these intensive production systems. Even though large farm and group sizes came under severe criticism, it is still unknown whether these factors indeed negatively affect animal welfare. Therefore, the aim of this study was to assess the effect of group size (30 pigs/pen) on various animal-based measures of the Welfare Quality(®) protocol for growing pigs under conventional fattening conditions. A total of 60 conventional pig fattening farms with different group sizes in Germany were included. Moderate bursitis (35%) was found as the most prevalent indicator of welfare-related problems, while its prevalence increased with age during the fattening period. However, differences between group sizes were not detected (P>0.05). The prevalence of moderately soiled bodies increased from 9.7% at the start to 14.2% at the end of the fattening period, whereas large pens showed a higher prevalence (15.8%) than small pens (10.4%; P<0.05). With increasing group size, the incidence of moderate wounds with 8.5% and 11.3% in small- and medium-sized pens, respectively, was lower (P<0.05) than in large-sized ones (16.3%). Contrary to bursitis and dirtiness, its prevalence decreased during the fattening period. Moderate manure was less often found in pigs fed by a dry feeder than in those fed by a liquid feeding system (P<0.05). The human-animal relationship was improved in large in comparison to small groups. On the contrary, negative social behaviour was found more often in large groups. Exploration of enrichment material decreased with increasing live weight. Given that all animals were tail-docked, tail biting was observed at a very low rate of 1.9%. In conclusion, the results indicate that BW and feeding system are determining factors for the welfare status, while group size was not proved to affect the welfare level under the studied conditions of pig fattening.

Effect size comparison of ketorolac nasal spray and commonly prescribed oral combination opioids for pain relief after third molar extraction surgery.

PubMed

Niebler, Gwendolyn; Dayno, Jeffrey

2016-01-01

Opioids are frequently used for treatment of moderate to severe short-term pain, but concerns exist about this treatment approach. Ketorolac tromethamine nasal spray, a nonsteroidal anti-inflammatory, is indicated for the short-term management of moderate to moderately severe pain requiring analgesia at the opioid level. However, there are no direct comparison studies between ketorolac nasal spray and opioids. The objective of this study was to use an effect size analysis to compare the effectiveness of ketorolac nasal spray with oral combination opioid formulations in treating moderate to severe short-term pain. An effect size analysis of three randomized, double-blind, placebo-controlled studies of third molar extraction surgery compared pain relief with ketorolac nasal spray and commonly prescribed combination opioids including hydrocodone/acetaminophen (APAP), oxycodone/APAP, oxycodone/ibuprofen and tramadol HCl/APAP. Effect size comparisons were made using total pain relief scores (TOTPAR6 or TOTPAR8; the weighted sum of pain relief scores through 6 or 8 h). Pain relief was measured using a five-point categorical rating scale (0 = none; 4 = complete). The effect size equivalent correlation, r, was determined using an online effect size calculator. The treatment effect size r compared with placebo was classified using established criteria (small = 0.20-0.49, moderate = 0.50-0.79 and large = ≥ 0.80). TOTPAR6 data indicated a moderate effect size for ketorolac nasal spray 31.5 mg (0.51) and oxycodone/ibuprofen 5/400 mg (0.64) and a small effect size for hydrocodone/APAP 7.5/500 mg (0.24) and oxycodone/APAP 5/325 mg (0.32). TOTPAR8 data indicated small effect sizes for ketorolac nasal spray (0.48), hydrocodone/APAP 10/650 mg (0.43), tramadol HCl/APAP 75/650 mg (0.35) and tramadol HCl/APAP 37.5/325 mg (0.17). The treatment effect sizes of ketorolac nasal spray were similar to or higher than the opioid comparators after third molar surgery, a well-accepted pain model. These results support ketorolac nasal spray as an effective treatment for moderate to moderately severe short-term pain.

13 CFR 121.102 - How does SBA establish size standards?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How does SBA establish size standards? 121.102 Section 121.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Provisions of General Applicability...

13 CFR 121.102 - How does SBA establish size standards?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false How does SBA establish size standards? 121.102 Section 121.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Provisions of General Applicability...

Infrapopulations of Gyliauchen volubilis Nagaty, 1956 (Trematoda: Gyliauchenidae) in the rabbitfish Siganus rivulatus (Teleostei: Siganidae) from the Saudi coast of the Red Sea.

PubMed

Al-Jahdali, M O

2012-08-01

In hermaphroditic helminth parasites, infrapopulation size or mating group size mostly affects some processes acting within the infrapopulation. Here, 30 natural infrapopulations (12-154 individuals) of the intestinal trematode Gyliauchen volubilis Nagaty, 1956 from the fish Siganus rivulatus consisting of newly excysted juveniles, immature and mature worms were found distributed in a well-defined fundamental niche (anterior 40% of the intestine). In small infrapopulations, all stages of the parasite were alive. In larger infrapopulations, differential mortality was only and consistently observed among newly excysted juveniles, and gradually increased to include most or all juveniles in the largest infrapopulations. Among mature worms, the mean worm length seemed unaffected by the infrapopulation size. However, the ratio mean testis size-mean ovary size, a reliable indicator of resource allocation to the male function and of opportunities for cross fertilization, significantly increased with mating group size. In small infrapopulations, all stages of the parasite were scattered along the niche, and never seen in mating pairs (possibly reproduced by self-fertilization). In larger infrapopulations, newly excysted juveniles and immature worms were scattered along the anterior two thirds of the niche, while mature worms were constantly found aggregated in its posterior third (narrow microhabitat), where some were arranged in mating pairs. The probability of mating reciprocally or unilaterally was dependent on body size. The mean number of uterine eggs per worm significantly decreased and their mean sizes significantly increased with mating group size. The results are statistically significant and suggest that infrapopulation self-regulation is greatly associated with its size.

Large- and small-size advantages in sneaking behaviour in the dusky frillgoby Bathygobius fuscus.

PubMed

Takegaki, Takeshi; Kaneko, Takashi; Matsumoto, Yukio

2012-04-01

Sneaking tactic, a male alternative reproductive tactic involving sperm competition, is generally adopted by small individuals because of its inconspicuousness. However, large size has an advantage when competition occurs between sneakers for fertilization of eggs. Here, we suggest that both large- and small-size advantages of sneaker males are present within the same species. Large sneaker males of the dusky frillgoby Bathygobius fuscus showed a high success rate in intruding into spawning nests because of their advantage in competition among sneaker males in keeping a suitable position to sneak, whereas small sneakers had few chances to sneak. However, small sneaker males were able to stay in the nests longer than large sneaker males when they succeeded in sneak intrusion. This suggests the possibility of an increase in their paternity. The findings of these size-specific behavioural advantages may be important in considering the evolution of size-related reproductive traits.

Large- and small-size advantages in sneaking behaviour in the dusky frillgoby Bathygobius fuscus

NASA Astrophysics Data System (ADS)

Takegaki, Takeshi; Kaneko, Takashi; Matsumoto, Yukio

2012-04-01

Sneaking tactic, a male alternative reproductive tactic involving sperm competition, is generally adopted by small individuals because of its inconspicuousness. However, large size has an advantage when competition occurs between sneakers for fertilization of eggs. Here, we suggest that both large- and small-size advantages of sneaker males are present within the same species. Large sneaker males of the dusky frillgoby Bathygobius fuscus showed a high success rate in intruding into spawning nests because of their advantage in competition among sneaker males in keeping a suitable position to sneak, whereas small sneakers had few chances to sneak. However, small sneaker males were able to stay in the nests longer than large sneaker males when they succeeded in sneak intrusion. This suggests the possibility of an increase in their paternity. The findings of these size-specific behavioural advantages may be important in considering the evolution of size-related reproductive traits.

Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness

PubMed Central

Davis, Brian W.; Schoenebeck, Jeffrey J.

2017-01-01

Domestic dog breeds display significant diversity in both body mass and skeletal size, resulting from intensive selective pressure during the formation and maintenance of modern breeds. While previous studies focused on the identification of alleles that contribute to small skeletal size, little is known about the underlying genetics controlling large size. We first performed a genome-wide association study (GWAS) using the Illumina Canine HD 170,000 single nucleotide polymorphism (SNP) array which compared 165 large-breed dogs from 19 breeds (defined as having a Standard Breed Weight (SBW) >41 kg [90 lb]) to 690 dogs from 69 small breeds (SBW ≤41 kg). We identified two loci on the canine X chromosome that were strongly associated with large body size at 82–84 megabases (Mb) and 101–104 Mb. Analyses of whole genome sequencing (WGS) data from 163 dogs revealed two indels in the Insulin Receptor Substrate 4 (IRS4) gene at 82.2 Mb and two additional mutations, one SNP and one deletion of a single codon, in Immunoglobulin Superfamily member 1 gene (IGSF1) at 102.3 Mb. IRS4 and IGSF1 are members of the GH/IGF1 and thyroid pathways whose roles include determination of body size. We also found one highly associated SNP in the 5’UTR of Acyl-CoA Synthetase Long-chain family member 4 (ACSL4) at 82.9 Mb, a gene which controls the traits of muscling and back fat thickness. We show by analysis of sequencing data from 26 wolves and 959 dogs representing 102 domestic dog breeds that skeletal size and body mass in large dog breeds are strongly associated with variants within IRS4, ACSL4 and IGSF1. PMID:28257443

Cohesion of Mm- to Cm-Sized Asteroid Simulant Grains: An Experimental Study

NASA Astrophysics Data System (ADS)

Brisset, Julie; Colwell, Joshua E.; Dove, Adrienne; Jarmak, Stephanie; Anderson, Seamus

2017-10-01

The regolith covering the surfaces of asteroids and planetary satellites is very different from terrestrial soil particles and subject to environmental conditions very different from what is found on Earth. The loose, unconsolidated granular material has angular-shaped grains and a broad size distribution. On small and airless bodies (<10 km), the solar wind leads to a depletion of fine grains (<100µm) on the surface. Ground observations of the two asteroids currently targeted by spacecraft, Ryugu (Hayabusa-2) and Bennu (OSIRIS-REx), indicate that their surfaces could be covered in mm- to cm-sized regolith grains. As these small bodies have surface gravity levels below 10-5g, g being the Earth surface gravity, the cohesion behavior of the regolith grains will dictate the asteroid’s surface morphology and its response to impact or spacecraft contact.Previous laboratory experiments on low-velocity impacts into regolith simulant with grain sizes <250 µm have revealed a transition of the grain behavior from a gravity-dominated regime to a cohesion-dominated regime when the local gravity level reaches values below 10-3g. This is in good agreement with analytical and simulation studies for these grain sizes. From the expected grain sizes at the surfaces of Ryugu and Bennu, we have now focused on larger grain sizes ranging from mm to cm. We have carried out a series of experiments to study the cohesion behavior of such larger grains of asteroid regolith simulant. The simulant used was CI Orgueil of Deep Space Industries. Experiments included laboratory tabletop avalanching, compression and shear force measurements, as well as low-velocity impacts under microgravity.Our goal is to determine if the grain size distribution has an influence on the cohesion behavior of the regolith and if we can validate numerical simulation results with experimental measurements. We will discuss the implications of our results for sample return or landing missions to small bodies such as asteroids or Martian moons.

Quantifying Spot Size Reduction of a 1.8 kA Electron Beam for Flash Radiography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burris-Mog, Trevor John; Moir, David C.

The spot size of Axis-I at the Dual Axis Radiographic Hydrodynamic Test facility was reduced by 15.5% by including a small diameter drift tube that acts to aperture the outer diameter of the electron beam. Comparing the measured values to both analytic calculations and results from a particle-in-cell model shows that one-third to one-half of the spot size reduction is due to a drop in beam emittance. We infer that one-half to two-thirds of the spot-size reduction is due to a reduction in beam-target interactions. Sources of emittance growth and the scaling of the final focal spot size with emittancemore » and solenoid aberrations are also presented.« less

Quantifying Spot Size Reduction of a 1.8 kA Electron Beam for Flash Radiography

DOE PAGES

Burris-Mog, Trevor John; Moir, David C.

2018-03-14

The spot size of Axis-I at the Dual Axis Radiographic Hydrodynamic Test facility was reduced by 15.5% by including a small diameter drift tube that acts to aperture the outer diameter of the electron beam. Comparing the measured values to both analytic calculations and results from a particle-in-cell model shows that one-third to one-half of the spot size reduction is due to a drop in beam emittance. We infer that one-half to two-thirds of the spot-size reduction is due to a reduction in beam-target interactions. Sources of emittance growth and the scaling of the final focal spot size with emittancemore » and solenoid aberrations are also presented.« less

Angular-domain scattering interferometry.

PubMed

Shipp, Dustin W; Qian, Ruobing; Berger, Andrew J

2013-11-15

We present an angular-scattering optical method that is capable of measuring the mean size of scatterers in static ensembles within a field of view less than 20 μm in diameter. Using interferometry, the method overcomes the inability of intensity-based models to tolerate the large speckle grains associated with such small illumination areas. By first estimating each scatterer's location, the method can model between-scatterer interference as well as traditional single-particle Mie scattering. Direct angular-domain measurements provide finer angular resolution than digitally transformed image-plane recordings. This increases sensitivity to size-dependent scattering features, enabling more robust size estimates. The sensitivity of these angular-scattering measurements to various sizes of polystyrene beads is demonstrated. Interferometry also allows recovery of the full complex scattered field, including a size-dependent phase profile in the angular-scattering pattern.

Inertial impaction air sampling device

DOEpatents

Dewhurst, Katharine H.

1990-01-01

An inertial impactor to be used in an air sampling device for collection of respirable size particles in ambient air which may include a graphite furnace as the impaction substrate in a small-size, portable, direct analysis structure that gives immediate results and is totally self-contained allowing for remote and/or personal sampling. The graphite furnace collects suspended particles transported through the housing by means of the air flow system, and these particles may be analyzed for elements, quantitatively and qualitatively, by atomic absorption spectrophotometry.

Inertial impaction air sampling device

DOEpatents

Dewhurst, K.H.

1987-12-10

An inertial impactor to be used in an air sampling device for collection of respirable size particles in ambient air which may include a graphite furnace as the impaction substrate in a small-size, portable, direct analysis structure that gives immediate results and is totally self-contained allowing for remote and/or personal sampling. The graphite furnace collects suspended particles transported through the housing by means of the air flow system, and these particles may be analyzed for elements, quantitatively and qualitatively, by atomic absorption spectrophotometry. 3 figs.

Evolution of extreme body size disparity in monitor lizards (Varanus).

PubMed

Collar, David C; Schulte, James A; Losos, Jonathan B

2011-09-01

Many features of species' biology, including life history, physiology, morphology, and ecology are tightly linked to body size. Investigation into the causes of size divergence is therefore critical to understanding the factors shaping phenotypic diversity within clades. In this study, we examined size evolution in monitor lizards (Varanus), a clade that includes the largest extant lizard species, the Komodo dragon (V. komodoensis), as well as diminutive species that are nearly four orders of magnitude smaller in adult body mass. We demonstrate that the remarkable body size disparity of this clade is a consequence of different selective demands imposed by three major habitat use patterns-arboreality, terrestriality, and rock-dwelling. We reconstructed phylogenetic relationships and ancestral habitat use and applied model selection to determine that the best-fitting evolutionary models for species' adult size are those that infer oppositely directed adaptive evolution associated with terrestriality and rock-dwelling, with terrestrial lineages evolving extremely large size and rock-dwellers becoming very small. We also show that habitat use affects the evolution of several ecologically important morphological traits independently of body size divergence. These results suggest that habitat use exerts a strong, multidimensional influence on the evolution of morphological size and shape disparity in monitor lizards. © 2011 The Author(s).

Spontaneous Regression of Pulmonary Nodules Presenting as Epstein-Barr Virus-related Atypical Infectious Mononucleosis.

PubMed

Shinozuka, Jun; Awaguni, Hitoshi; Tanaka, Shin-Ichiro; Makino, Shigeru; Maruyama, Rikken; Inaba, Tohru; Imashuku, Shinsaku

2016-07-01

Pulmonary nodules associated with Epstein-Barr virus (EBV)-related atypical infectious mononucleosis have rarely been described. A 12-year-old Japanese boy, upon admission, revealed multiple small round nodules (a total of 7 nodules in 4 to 8 mm size) in the lungs on computed tomography. The hemorrhagic pharyngeal tonsils with hot signals on 18F-fluorodeoxyglucose-positron emission tomography-computed tomography were biopsied revealing the presence of EBV-encoded small nuclear RNA (EBER)-positive cells; however, no lymphoma was noted. The patient was diagnosed as having atypical EBV-infectious mononucleosis associated with primary EBV infection. Pulmonary nodules markedly reduced in numbers and sizes spontaneously over a 2-year period. Differential diagnosis of pulmonary nodules in childhood should include atypical EBV infection.

7 CFR 51.1527 - Standard pack.

Code of Federal Regulations, 2013 CFR

2013-01-01

... size, 45 size, 50 size, 55 size, etc.). (i) California peach boxes, lug boxes and small consumer packages. In layer-packed California peach boxes or lug boxes, and in small layer packed consumer packages... California peach boxes or lug boxes shall not vary more than 4 from the number indicated on the package...

7 CFR 51.1527 - Standard pack.

Code of Federal Regulations, 2014 CFR

2014-01-01

... size, 45 size, 50 size, 55 size, etc.). (i) California peach boxes, lug boxes and small consumer packages. In layer-packed California peach boxes or lug boxes, and in small layer packed consumer packages... California peach boxes or lug boxes shall not vary more than 4 from the number indicated on the package...

13 CFR 121.108 - What are the penalties for misrepresentation of size status?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the penalties for misrepresentation of size status? 121.108 Section 121.108 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards Provisions of General...

Hallmarks of a Successful CBO.

ERIC Educational Resources Information Center

Ginsburg, Sigmund G.

2003-01-01

Describes the attributes and actions that underlie the success of a chief business officer, drawing on the experiences of a chief business and chief financial officer at four types of institutions, including a museum, a small independent college, a large state university, and a medium-sized independent university. (SLD)

Outstanding Reference Sources: The 1994 Selection of Recent Titles.

ERIC Educational Resources Information Center

Luchsinger, Dale F.

1994-01-01

Presents an annotated bibliography of 37 outstanding reference sources published in 1993 for small to medium-sized public and academic libraries as selected by the American Library Association's Reference Services Committee. Categories include culture and civilization, biography, general, language and literature, nature, law, religion, technology,…

An Integrated Library System: Preliminary Considerations.

ERIC Educational Resources Information Center

Neroda, Edward

Noting difficulties experienced by small to medium sized colleges in acquiring integrated library computer systems, this position paper outlines issues related to the subject with the intention of increasing familiarity and interest in integrated library systems. The report includes: a brief review of technological advances as they relate to…

78 FR 60275 - Alternative Method for Calculating Off-Cycle Credits for Mercedes-Benz Vehicles Under the Light...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

...., small/mid-size/large cars and light-duty trucks) (See Section II-III of Mercedes-Benz Application...-start effectiveness unless the vehicle possesses an electric heater circulation pump, or equivalent...-start system includes an electric [[Page 60278

The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell

PubMed Central

Kovacevic, Ismar; Bao, Zhirong

2018-01-01

C. elegans cell divisions that produce an apoptotic daughter cell exhibit Daughter Cell Size Asymmetry (DCSA), producing a larger surviving daughter cell and a smaller daughter cell fated to die. Genetic screens for mutants with defects in apoptosis identified several genes that are also required for the ability of these divisions to produce daughter cells that differ in size. One of these genes, ham-1, encodes a putative transcription factor that regulates a subset of the asymmetric cell divisions that produce an apoptotic daughter cell. In a survey of C. elegans divisions, we found that ham-1 mutations affect primarily anterior/posterior divisions that produce a small anterior daughter cell. The affected divisions include those that generate an apoptotic cell as well as those that generate two surviving cells. Our findings suggest that HAM-1 primarily promotes DCSA in a certain class of asymmetric divisions. PMID:29668718

Respiratory Symptoms Following Wildfire Smoke Exposure

PubMed Central

Mirabelli, Maria C.; Künzli, Nino; Avol, Edward; Gilliland, Frank D.; Gauderman, W. James; McConnell, Rob; Peters, John M.

2015-01-01

Background Associations between exposure to smoke during wild-fire events and respiratory symptoms are well documented, but the role of airway size remains unclear. We conducted this analysis to assess whether small airway size modifies these relationships. Methods We analyzed data from 465 nonasthmatic 16- to 19-year-old participants in the Children’s Health Study. Following an outbreak of wildfires in 2003, each student completed a questionnaire about smoke exposure, dry and wet cough, wheezing, and eye symptoms. We used log-binomial regression to evaluate associations between smoke exposure and fire-related health symptoms, and to assess modification of the associations by airway size. As a marker of airway size, we used the ratio of maximum midexpiratory flow to forced vital capacity. Results Forty percent (186 of 465) of this population (including students from 11 of 12 surveyed communities) reported the odor of wildfire smoke at home. We observed increased respiratory and eye symptoms with increasing frequency of wildfire smoke exposure. Associations between smoke exposure and having any of 4 respiratory symptoms were stronger in the lowest quartile of the lung function ratio (eg, fire smoke 6+ days: prevalence ratio: 3.8; 95% confidence interval (CI = 2.0 –7.2), compared with the remaining quartiles (fire smoke 6+ days: prevalence ratio = 2.0; 1.2–3.2). Analysis of individual symptoms suggests that this interaction may be strongest for effects on wheezing. Conclusions Small airways may serve as a marker of susceptibility to effects of wildfire smoke. Future studies should investigate the role of airway size for more common exposures and should include persons with asthma. PMID:19276978

Exploring the Genetic Signature of Body Size in Yucatan Miniature Pig

PubMed Central

Kim, Hyeongmin; Song, Ki Duk; Kim, Hyeon Jeong; Park, WonCheoul; Kim, Jaemin; Lee, Taeheon; Shin, Dong-Hyun; Kwak, Woori; Kwon, Young-jun; Sung, Samsun; Moon, Sunjin; Lee, Kyung-Tai; Kim, Namshin; Hong, Joon Ki; Eo, Kyung Yeon; Seo, Kang Seok; Kim, Girak; Park, Sungmoo; Yun, Cheol-Heui; Kim, Hyunil; Choi, Kimyung; Kim, Jiho; Lee, Woon Kyu; Kim, Duk-Kyung; Oh, Jae-Don; Kim, Eui-Soo; Cho, Seoae; Lee, Hak-Kyo; Kim, Tae-Hun; Kim, Heebal

2015-01-01

Since being domesticated about 10,000–12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig. PMID:25885114

Evaluation research of small and medium-sized enterprise informatization on big data

NASA Astrophysics Data System (ADS)

Yang, Na

2017-09-01

Under the background of big data, key construction of small and medium-sized enterprise informationization level was needed, but information construction cost was large, while information cost of inputs can bring benefit to small and medium-sized enterprises. This paper established small and medium-sized enterprise informatization evaluation system from hardware and software security level, information organization level, information technology application and the profit level, and information ability level. The rough set theory was used to brief indexes, and then carry out evaluation by support vector machine (SVM) model. At last, examples were used to verify the theory in order to prove the effectiveness of the method.

The Effect of Different Oceanic Abiotic Factors on Prokaryotic Body Sizes

NASA Astrophysics Data System (ADS)

Pidathala, S.; Bellon, M.; Heim, N.; Payne, J.

2016-12-01

We are studying the impact of abiotic factors in the Pacific and Atlantic on prokaryotic body sizes and genome sizes because we are interested in the manner in which abiotic factors influence genome sizes independent of their influence on body sizes. Some research has been done in the past on marine bacterial evolution, including data collection on marine ecology in relation to bacterial body sizes (Straza 2009). We are using the abiotic factors: temperature, salinity, and pH to compare the biovolumes/genome sizes of different phyla by using R. We made 9 scatter plots to model these relationships. Regardless of the phyla or the ocean, we found that there is no relation between pH, temperature, and body size, with several exceptions: Deinococcus. thermus has an indirect relationship with size in respect to temperature; size only correlates to temperature for phyla that are thermophiles. We also found that bacteria like D. thermus and Thermotogae are taxa only found in higher temperatures. Additionally, almost all phyla have genome sizes restricted by certain pH levels:, Proteobacteria only reach genomes with acidity levels greater than 6. In terms of salinity levels, certain bacteria are only found within a small range, and others, like Proteobacteria, can only reach genomes at low salinity levels. Finally, Proteobacteria have large genome sizes between 30 and 40 °, and Crenarchaeota have constant genome sizes in higher temperatures. Conclusively, we discovered that these abiotic factors generally do not affect body size, with the exception of D. thermus' indirect relationship to temperature due to its small biovolume in high temperatures. However, we determined that these abiotic factors have a great impact on genome sizes. This is due to genome size independence from body size. Also, genome size could have served as an adaptive feature for bacteria in marine environments, explaining why different phyla may have diverged to accommodate their lifestyles.

78 FR 20371 - Small Business Size Standards; Waiver of the Nonmanufacturer Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-04

... SMALL BUSINESS ADMINISTRATION Small Business Size Standards; Waiver of the Nonmanufacturer Rule AGENCY: U.S. Small Business Administration. ACTION: On April 16, 2001, SBA granted a Class Waiver of the Nonmanufacturer Rule (NMR) for Aerospace Ball and Roller Bearings, North American Industry Classification System...

The flight of a balsa glider

NASA Astrophysics Data System (ADS)

Waltham, Chris

1999-07-01

A simple analysis is performed on the flight of a small balsa toy glider. All the basic features of flight have to be included in the calculation. Key differences between the flight of small objects like the glider, and full-sized aircraft, are examined. Good agreement with experimental data is obtained when only one parameter, the drag coefficient, is allowed to vary. The experimental drag coefficient is found to be within a factor of 2 of that obtained using the theory of ideal flat plates.

Corona graphs as a model of small-world networks

NASA Astrophysics Data System (ADS)

Lv, Qian; Yi, Yuhao; Zhang, Zhongzhi

2015-11-01

We introduce recursive corona graphs as a model of small-world networks. We investigate analytically the critical characteristics of the model, including order and size, degree distribution, average path length, clustering coefficient, and the number of spanning trees, as well as Kirchhoff index. Furthermore, we study the spectra for the adjacency matrix and the Laplacian matrix for the model. We obtain explicit results for all the quantities of the recursive corona graphs, which are similar to those observed in real-life networks.

[Small vessel cerebrovascular disease].

PubMed

Cardona Portela, P; Escrig Avellaneda, A

2018-05-09

Small vessel vascular disease is a spectrum of different conditions that includes lacunar infarction, alteration of deep white matter, or microbleeds. Hypertension is the main risk factor, although the atherothrombotic lesion may be present, particularly in large-sized lacunar infarctions along with other vascular risk factors. MRI findings are characteristic and the lesions authentic biomarkers that allow differentiating the value of risk factors and defining their prognostic value. Copyright © 2018 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

CubeSat Batteries

NASA Image and Video Library

2017-01-11

Daniel Perez, Ph.D., a graduate student from the University of Miami, displays a piece of the prototype structure for a new solid-state battery in the Prototype Laboratory at NASA's Kennedy Space Center in Florida. The size of the battery is so small that it could be a prime candidate for use in microsatellites, including CubeSats. Researchers at Kennedy are collaborating with experts at the University of Miami. The university partnership is funded through the Small Spacecraft Technology Program, in NASA's Space Technology Mission Directorate.

CubeSat Batteries

NASA Image and Video Library

2017-01-11

Daniel Perez, Ph.D., a graduate student from the University of Miami, prepares layers of the prototype structure for a new solid-state battery in the Prototype Laboratory at NASA's Kennedy Space Center in Florida. The size of the battery is so small that it could be a prime candidate for use in microsatellites, including CubeSats. Researchers at Kennedy are collaborating with experts at the University of Miami. The university partnership is funded through the Small Spacecraft Technology Program, in NASA's Space Technology Mission Directorate.

75 FR 1296 - Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

... program and small business size standards. In conjunction with the public meetings SBA is conducting... supplements his or her testimony. Electronic or digitized copies are encouraged. In conjunction with the...

Venus small volcano classification and description

NASA Technical Reports Server (NTRS)

Aubele, J. C.

1993-01-01

The high resolution and global coverage of the Magellan radar image data set allows detailed study of the smallest volcanoes on the planet. A modified classification scheme for volcanoes less than 20 km in diameter is shown and described. It is based on observations of all members of the 556 significant clusters or fields of small volcanoes located and described by this author during data collection for the Magellan Volcanic and Magmatic Feature Catalog. This global study of approximately 10 exp 4 volcanoes provides new information for refining small volcano classification based on individual characteristics. Total number of these volcanoes was estimated to be 10 exp 5 to 10 exp 6 planetwide based on pre-Magellan analysis of Venera 15/16, and during preparation of the global catalog, small volcanoes were identified individually or in clusters in every C1-MIDR mosaic of the Magellan data set. Basal diameter (based on 1000 measured edifices) generally ranges from 2 to 12 km with a mode of 34 km, and follows an exponential distribution similar to the size frequency distribution of seamounts as measured from GLORIA sonar images. This is a typical distribution for most size-limited natural phenomena unlike impact craters which follow a power law distribution and continue to infinitely increase in number with decreasing size. Using an exponential distribution calculated from measured small volcanoes selected globally at random, we can calculate total number possible given a minimum size. The paucity of edifice diameters less than 2 km may be due to inability to identify very small volcanic edifices in this data set; however, summit pits are recognizable at smaller diameters, and 2 km may represent a significant minimum diameter related to style of volcanic eruption. Guest, et al, discussed four general types of small volcanic edifices on Venus: (1) small lava shields; (2) small volcanic cones; (3) small volcanic domes; and (4) scalloped margin domes ('ticks'). Steep-sided domes or 'pancake domes', larger than 20 km in diameter, were included with the small volcanic domes. For the purposes of this study, only volcanic edifices less than 20 km in diameter are discussed. This forms a convenient cutoff since most of the steep-sided domes ('pancake domes') and scalloped margin domes ('ticks') are 20 to 100 km in diameter, are much less numerous globally than are the smaller diameter volcanic edifices (2 to 3 orders of magnitude lower in total global number), and do not commonly occur in large clusters or fields of large numbers of edifices.

77 FR 30227 - Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... 19, 2012, in Austin, TX. These Roundtable Meetings will be conducted by SBA's Office of Advocacy. For... p.m. EST. Austin, TX June 19, 2012, 10 a.m.-2 p.m. EST June 14, 2012, 11:59 p.m. EST. III... Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small Business Technology...

13 CFR 121.603 - How does SBA determine whether a Participant is small for a particular 8(a) BD subcontract?

Code of Federal Regulations, 2013 CFR

2013-01-01

... Participant is small for a particular 8(a) BD subcontract? 121.603 Section 121.603 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and... Participant. A 8(a) BD Participant must certify that it qualifies as a small business under the NAICS code...

13 CFR 121.603 - How does SBA determine whether a Participant is small for a particular 8(a) BD subcontract?

Code of Federal Regulations, 2014 CFR

2014-01-01

... Participant is small for a particular 8(a) BD subcontract? 121.603 Section 121.603 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and... Participant. A 8(a) BD Participant must certify that it qualifies as a small business under the NAICS code...

13 CFR 121.603 - How does SBA determine whether a Participant is small for a particular 8(a) BD subcontract?

Code of Federal Regulations, 2012 CFR

2012-01-01

... Participant is small for a particular 8(a) BD subcontract? 121.603 Section 121.603 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and... Participant. A 8(a) BD Participant must certify that it qualifies as a small business under the NAICS code...

13 CFR 121.603 - How does SBA determine whether a Participant is small for a particular 8(a) BD subcontract?

Code of Federal Regulations, 2011 CFR

2011-01-01

... Participant is small for a particular 8(a) BD subcontract? 121.603 Section 121.603 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and... Participant. A 8(a) BD Participant must certify that it qualifies as a small business under the NAICS code...

Spatial and seasonal dynamics of brook trout populations inhabiting a central Appalachian watershed

USGS Publications Warehouse

Petty, J.T.; Lamothe, P.J.; Mazik, P.M.

2005-01-01

We quantified the watershed-scale spatial population dynamics of brook trout Salvelinus fontinalis in the Second Fork, a third-order tributary of Shavers Fork in eastern West Virginia. We used visual surveys, electrofishing, and mark-recapture techniques to quantify brook trout spawning intensity, population density, size structure, and demographic rates (apparent survival and immigration) throughout the watershed. Our analyses produced the following results. Spawning by brook trout was concentrated in streams with small basin areas (i.e., segments draining less than 3 km2), relatively high alkalinity (>10 mg CaCO3/L), and high amounts of instream cover. The spatial distribution of juvenile and small-adult brook trout within the watershed was relatively stable and was significantly correlated with spawning intensity. However, no such relationship was observed for large adults, which exhibited highly variable distribution patterns related to seasonally important habitat features, including instream cover, stream depth and width, and riparian canopy cover. Brook trout survival and immigration rates varied seasonally, spatially, and among size-classes. Differential survival and immigration tended to concentrate juveniles and small adults in small, alkaline streams, whereas dispersal tended to redistribute large adults at the watershed scale. Our results suggest that spatial and temporal variations in spawning, survival, and movement interact to determine the distribution, abundance, and size structure of brook trout populations at a watershed scale. These results underscore the importance of small tributaries for the persistence of brook trout in this watershed and the need to consider watershed-scale processes when designing management plans for Appalachian brook trout populations. ?? Copyright by the American Fisheries Society 2005.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pauly, Tyler; Garrod, Robin T., E-mail: tap74@cornell.edu

Computational models of interstellar gas-grain chemistry have historically adopted a single dust-grain size of 0.1 micron, assumed to be representative of the size distribution present in the interstellar medium. Here, we investigate the effects of a broad grain-size distribution on the chemistry of dust-grain surfaces and the subsequent build-up of molecular ices on the grains, using a three-phase gas-grain chemical model of a quiescent dark cloud. We include an explicit treatment of the grain temperatures, governed both by the visual extinction of the cloud and the size of each individual grain-size population. We find that the temperature difference plays amore » significant role in determining the total bulk ice composition across the grain-size distribution, while the effects of geometrical differences between size populations appear marginal. We also consider collapse from a diffuse to a dark cloud, allowing dust temperatures to fall. Under the initial diffuse conditions, small grains are too warm to promote grain-mantle build-up, with most ices forming on the mid-sized grains. As collapse proceeds, the more abundant, smallest grains cool and become the dominant ice carriers; the large population of small grains means that this ice is distributed across many grains, with perhaps no more than 40 monolayers of ice each (versus several hundred assuming a single grain size). This effect may be important for the subsequent processing and desorption of the ice during the hot-core phase of star formation, exposing a significant proportion of the ice to the gas phase, increasing the importance of ice-surface chemistry and surface–gas interactions.« less

Impact of Annular Size on Outcomes After Surgical or Transcatheter Aortic Valve Replacement.

PubMed

Deeb, G Michael; Chetcuti, Stanley J; Yakubov, Steven J; Patel, Himanshu J; Grossman, P Michael; Kleiman, Neal S; Heiser, John; Merhi, William; Zorn, George L; Tadros, Peter N; Petrossian, George; Robinson, Newell; Mumtaz, Mubashir; Gleason, Thomas G; Huang, Jian; Conte, John V; Popma, Jeffrey J; Reardon, Michael J

2018-04-01

This analysis evaluates the relationship of annular size to hemodynamics and the incidence of prosthesis-patient mismatch (PPM) in surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) patients. The CoreValve US Pivotal High Risk Trial, described previously, compared TAVR using a self-expanding valve with SAVR. Multislice computed tomography was used to categorize TAVR and SAVR subjects according to annular perimeter-derived diameter: large (≥26 mm), medium (23 to <26 mm), and small (<23 mm). Hemodynamics, PPM, and clinical outcomes were assessed. At all postprocedure visits, mean gradients were significantly lower for TAVR compared with SAVR in small and medium size annuli (p < 0.001). Annular size was significantly associated with mean gradient after SAVR, with small annuli having the highest gradients (p < 0.05 at all timepoints); gradients were similar across all annular sizes after TAVR. In subjects receiving SAVR, the frequency of PPM was significantly associated with annular size, with small annuli having the greatest incidence. No difference in PPM incidence by annular sizing was observed with TAVR. In addition, TAVR subjects had significantly less PPM than SAVR subjects in small and medium annuli (p < 0.001), with no difference in the incidence of PPM between TAVR and SAVR in large annuli (p = 0.10). Annular size has a significant effect on hemodynamics and the incidence of PPM in SAVR subjects, not observed in TAVR subjects. With respect to annular size, TAVR results in better hemodynamics and less PPM for annuli less than 26 mm and should be strongly considered when choosing a tissue valve for small and medium size annuli. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

The effect of habitat patch size on small mammal populations

Treesearch

Mark D. Yates; Susan C. Loeb; David C. Guynn

1997-01-01

Habitat fragmentation is one of the greatest threats to the conservation of bio­diversity and has 3 components: habitat loss, patch isolation, and patch size. The authors tested the effects of forest-clearing size on small mammal populations in the Upper Coastal Plain of South Carolina. These clearings act as islands for many species of small mam­mals, particularly old...

Effects of Group Size on Students Mathematics Achievement in Small Group Settings

ERIC Educational Resources Information Center

Enu, Justice; Danso, Paul Amoah; Awortwe, Peter K.

2015-01-01

An ideal group size is hard to obtain in small group settings; hence there are groups with more members than others. The purpose of the study was to find out whether group size has any effects on students' mathematics achievement in small group settings. Two third year classes of the 2011/2012 academic year were selected from two schools in the…

13 CFR 121.411 - What are the size procedures for SBA's Section 8(d) Subcontracting Program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the size procedures for SBA's Section 8(d) Subcontracting Program? 121.411 Section 121.411 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS SIZE REGULATIONS Size Eligibility Provisions and Standards...

Prognostic Importance of Small Prostate Size in Men Receiving Definitive Prostate Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taira, Al V.; Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.org; Galbreath, Robert W.

Purpose: To assess whether small prostate size is an adverse prognostic factor in men undergoing brachytherapy in the same manner in which it seems to be for men undergoing radical prostatectomy. Methods and Materials: From April 1995 to June 2008, 2024 patients underwent brachytherapy by a single brachytherapist. Median follow-up was 7.4 years. The role of small prostate size ({<=}20 cm{sup 3}) as a prognostic factor for biochemical progression-free survival, cause-specific survival, and all-cause mortality was investigated. The differences in survival between men with small and larger prostates were compared using Kaplan-Meier curves and log-rank tests. Results: Median prostate sizemore » for the entire cohort was 32.7 cm{sup 3}. For the 167 men with small prostates, median prostate size was 17.4 cm{sup 3}. There was no difference in biochemical progression-free survival (95.2% vs 96.2%, P=.603), cause-specific survival (97.7% vs 98.3%, P=.546), or all-cause mortality (78.0% vs 77.2%, P=.838) at 10 years for men with small prostates compared with men with larger prostates. On univariate and multivariate analysis, small prostate size was not associated with any of the primary outcome measures. Conclusion: Men with small prostates treated with brachytherapy have excellent outcomes and are at no higher risk of treatment failure than men with larger glands. High-quality implants with adequate margins seem sufficient to address the increased adverse risk factors associated with small prostate size.« less

Seteria viridis as a model for pathogen resistance in the Poaceae

USDA-ARS?s Scientific Manuscript database

Seteria viridis is an effective model system for functional genetics in the C4 Poaceae grasses, which include important crops like maize, sorghum, and sugar cane. The small genome size, short stature, rapid life cycle, and the availability of genetic transformation protocols, make Seteria an attract...

A peptide derivatized cellulosic aerogel from cotton as a point of care diagnostic protease sensor

USDA-ARS?s Scientific Manuscript database

Lightweight aerogels are highly porous with usually very small pore size making them suitable for a variety of potential applications as sensors including deformation strain, humidity, organic vapors, thermal, and optical sensing properties. However, little has been reported on their use as biosenso...

75 FR 60408 - Government Programs To Assist Businesses Protect Their Intellectual Property Rights (IPR) in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... Small- and Medium-Sized Enterprises (SMEs), in foreign markets. As evidenced by the launch of the.... Identify specific challenges businesses, including SMEs, face in protecting their intellectual property... to SMEs? Should U.S. government programs focus on specific areas of intellectual property protection...

Recruiting Trends, 2007-2008

ERIC Educational Resources Information Center

Collegiate Employment Research Institute (NJ3), 2008

2008-01-01

This paper presents the recruiting trends for 2007-2008. This year's report is based on 994 respondents, including 84 K-12 school districts. The researchers focused attention on growing companies, based on lists from Forbes and Inc. magazines, and as a result, they have more small and medium-size employers represented this year. The sample…

Working towards Skills: Perspectives on Workforce Development in SMEs. Research Report.

ERIC Educational Resources Information Center

Hughes, Maria; Keddie, Vince; Webb, Peter; Corney, Mark

Research into workforce development (WD) considered the relationship between corporate assessments of workers' development needs and WD strategies; how learning at work takes place; and what learning methods are used and their effectiveness. Focus was on practice in small and medium-sized enterprises (SMEs). Methodology included a literature…

Integrating ecology and genetics to address Acari invasions

USDA-ARS?s Scientific Manuscript database

Because of their small size and tolerance to many of the control procedures used for a wide variety of commodities, Acari species have become one of the fastest, unwanted pest travelers since the beginning of this century. This special issue includes eleven studies on adventive and invasive Acari sp...

DEVELOPMENT AND PEER REVIEW OF TIME-TO-EFFECT MODELS FOR THE ANALYSIS OF NEUROTOXICITY AND OTHER TIME DEPENDENT DATA

EPA Science Inventory

Neurobehavioral studies pose unique challenges for dose-response modeling, including small sample size and relatively large intra-subject variation, repeated measurements over time, multiple endpoints with both continuous and ordinal scales, and time dependence of risk characteri...

QEEN Workshop: "Quantifying Exposure to Engineered Nano-materials from Manufactured Products": Write Up Biological Tissues and Media

EPA Science Inventory

The measurement and characterization of nanomaterials in biological tissues is complicated by a number of factors including: the sensitivity of the assay to small sized particles or low concentrations of materials; the ability to distinguish different forms and transformations of...

Size for Gestational Age and Neonatal Temperament.

ERIC Educational Resources Information Center

Riese, Marilyn L.

The appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) infants from 30 pairs of full-term and 15 pairs of preterm same-sex twins were compared for neonatal temperament. The evaluation of neonatal temperament included ratings of irritability, resistance to soothing, activity level, reactivity, and reinforcement value. Results…

Osteoporosis in Groups with Intellectual Disability.

ERIC Educational Resources Information Center

Center, J. R.; And Others

1994-01-01

Fifty-three adults with intellectual impairment referred to an endocrinology clinic in New South Wales (Australia) were measured for lumbar bone mineral density. Bone mineral density was significantly lower in this group than in an age and sex matched control group. Risk factors included male gender, physical inactivity, small body size,…

NOVEL RU-NI-S ELECTRODE CATALYST FOR PEMFC

EPA Science Inventory

The expected results from this project include:

• a new formula and preparation procedures for Ru-Ni-S catalyst;
• demonstration of CO and S tolerance of the new catalyst;
• a small size PEMFC with Ru-Ni-S catalyst and good performance; an...

• Capital and Operating Cost of Small Arsenic Removal System and their Most Frequent Maintenance Problems

  EPA Science Inventory

  This presentation will first summarize the capital and operating cost of treatment systems by type and size of the systems. The treatment systems include adsorptive media (AM) systems, iron removal (IR), coagulation/filtration (CF), ion exchange (IX) systems, and point-of-use rev...

• Low-Threshold Active Teaching Methods for Mathematic Instruction

  ERIC Educational Resources Information Center

  Marotta, Sebastian M.; Hargis, Jace

  2011-01-01

  In this article, we present a large list of low-threshold active teaching methods categorized so the instructor can efficiently access and target the deployment of conceptually based lessons. The categories include teaching strategies for lecture on large and small class sizes; student action individually, in pairs, and groups; games; interaction…

• 77 FR 55737 - Small Business Size Standards: Finance and Insurance and Management of Companies and Enterprises

  Federal Register 2010, 2011, 2012, 2013, 2014

  2012-09-11

  ...The U.S. Small Business Administration (SBA) proposes to increase small business size standards for 37 industries in North American Industry Classification System (NAICS) Sector 52, Finance and Insurance, and for two industries in NAICS Sector 55, Management of Companies and Enterprises. In addition, SBA proposes to change the measure of size from average assets to average receipts for NAICS 522293, International Trade Financing. As part of its ongoing comprehensive size standards review, SBA evaluated all receipts based and assets based size standards in NAICS Sectors 52 and 55 to determine whether they should be retained or revised. This proposed rule is one of a series of proposed rules that will review size standards of industries grouped by NAICS Sector. SBA issued a White Paper entitled ``Size Standards Methodology'' and published a notice in the October 21, 2009 issue of the Federal Register to advise the public that the document is available on its Web site at www.sba.gov/size for public review and comments. The ``Size Standards Methodology'' White Paper explains how SBA establishes, reviews, and modifies its receipts based and employee based small business size standards. In this proposed rule, SBA has applied its methodology that pertains to establishing, reviewing, and modifying a receipts based size standard.

• Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

  PubMed Central

  Watanabe, Toshiaki; Takeda, Atsushi; Tsukiyama, Tomoyuki; Mise, Kazuyuki; Okuno, Tetsuro; Sasaki, Hiroyuki; Minami, Naojiro; Imai, Hiroshi

  2006-01-01

  Small RNAs ranging in size between 18 and 30 nucleotides (nt) are found in many organisms including yeasts, plants, and animals. Small RNAs are involved in the regulation of gene expression through translational repression, mRNA degradation, and chromatin modification. In mammals, microRNAs (miRNAs) are the only small RNAs that have been well characterized. Here, we have identified two novel classes of small RNAs in the mouse germline. One class consists of ∼20- to 24-nt small interfering RNAs (siRNAs) from mouse oocytes, which are derived from retroelements including LINE, SINE, and LTR retrotransposons. Addition of retrotransposon-derived sequences to the 3′ untranslated region (UTR) of a reporter mRNA destabilizes the mRNA significantly when injected into full-grown oocytes. These results suggest that retrotransposons are suppressed through the RNAi pathway in mouse oocytes. The other novel class of small RNAs is 26- to 30-nt germline small RNAs (gsRNAs) from testes. gsRNAs are expressed during spermatogenesis in a developmentally regulated manner, are mapped to the genome in clusters, and have strong strand bias. These features are reminiscent of Tetrahymena ∼23- to 24-nt small RNAs and Caenorhabditis elegans X-cluster small RNAs. A conserved novel small RNA pathway may be present in diverse animals. PMID:16766679

Measuring the molecular dimensions of wine tannins: comparison of small-angle X-ray scattering, gel-permeation chromatography and mean degree of polymerization.

PubMed

McRae, Jacqui M; Kirby, Nigel; Mertens, Haydyn D T; Kassara, Stella; Smith, Paul A

2014-07-23

The molecular size of wine tannins can influence astringency, and yet it has been unclear as to whether the standard methods for determining average tannin molecular weight (MW), including gel-permeation chromatography (GPC) and depolymerization reactions, are actually related to the size of the tannin in wine-like conditions. Small-angle X-ray scattering (SAXS) was therefore used to determine the molecular sizes and corresponding MWs of wine tannin samples from 3 and 7 year old Cabernet Sauvignon wine in a variety of wine-like matrixes: 5-15% and 100% ethanol; 0-200 mM NaCl and pH 3.0-4.0, and compared to those measured using the standard methods. The SAXS results indicated that the tannin samples from the older wine were larger than those of the younger wine and that wine composition did not greatly impact on tannin molecular size. The average tannin MWs as determined by GPC correlated strongly with the SAXS results, suggesting that this method does give a good indication of tannin molecular size in wine-like conditions. The MW as determined from the depolymerization reactions did not correlate as strongly with the SAXS results. To our knowledge, SAXS measurements have not previously been attempted for wine tannins.

How much should I eat? Estimation of meal portions in anorexia nervosa.

PubMed

Milos, Gabriella; Kuenzli, Cornelia; Soelch, Chantal Martin; Schumacher, Sonja; Moergeli, Hanspeter; Mueller-Pfeiffer, Christoph

2013-04-01

Pathological concern regarding one's weight and weight gain is a crucial feature of anorexia nervosa. Consequently, anorexia nervosa patients often claim that they are uncertain regarding the amount of food they should eat. The present study investigated whether individuals with anorexia nervosa show an altered estimation of meal portion sizes and whether this estimation is modulated by an intent-to-eat instruction (where patients are asked to imagine having to eat the presented meal), meal type and meal portion size. Twenty-four women with anorexia nervosa and 27 healthy women estimated, using a visual analogue scale, the size of six different portions of three different meals, with and without intent-to-eat instructions. Subjects with anorexia nervosa estimated the size of small and medium meal portions (but not large meal servings) as being significantly larger, compared to estimates of healthy controls. The overestimation of small meal portions by anorexia nervosa subjects was significantly greater in the intent-to-eat, compared to general, condition. These findings suggest that disturbed perceptions associated with anorexia nervosa not only include interoceptive awareness (i.e., body weight and shape), but also extend to external disorder-related objects such as meal portion size. Specific therapeutic interventions, such as training regarding meal portion evaluation, could address these difficulties. Copyright © 2013. Published by Elsevier Ltd.

Photodiode area effect on performance of X-ray CMOS active pixel sensors

NASA Astrophysics Data System (ADS)

Kim, M. S.; Kim, Y.; Kim, G.; Lim, K. T.; Cho, G.; Kim, D.

2018-02-01

Compared to conventional TFT-based X-ray imaging devices, CMOS-based X-ray imaging sensors are considered next generation because they can be manufactured in very small pixel pitches and can acquire high-speed images. In addition, CMOS-based sensors have the advantage of integration of various functional circuits within the sensor. The image quality can also be improved by the high fill-factor in large pixels. If the size of the subject is small, the size of the pixel must be reduced as a consequence. In addition, the fill factor must be reduced to aggregate various functional circuits within the pixel. In this study, 3T-APS (active pixel sensor) with photodiodes of four different sizes were fabricated and evaluated. It is well known that a larger photodiode leads to improved overall performance. Nonetheless, if the size of the photodiode is > 1000 μm2, the degree to which the sensor performance increases as the photodiode size increases, is reduced. As a result, considering the fill factor, pixel-pitch > 32 μm is not necessary to achieve high-efficiency image quality. In addition, poor image quality is to be expected unless special sensor-design techniques are included for sensors with a pixel pitch of 25 μm or less.

High correlations between MRI brain volume measurements based on NeuroQuant® and FreeSurfer.

PubMed

Ross, David E; Ochs, Alfred L; Tate, David F; Tokac, Umit; Seabaugh, John; Abildskov, Tracy J; Bigler, Erin D

2018-05-30

NeuroQuant ® (NQ) and FreeSurfer (FS) are commonly used computer-automated programs for measuring MRI brain volume. Previously they were reported to have high intermethod reliabilities but often large intermethod effect size differences. We hypothesized that linear transformations could be used to reduce the large effect sizes. This study was an extension of our previously reported study. We performed NQ and FS brain volume measurements on 60 subjects (including normal controls, patients with traumatic brain injury, and patients with Alzheimer's disease). We used two statistical approaches in parallel to develop methods for transforming FS volumes into NQ volumes: traditional linear regression, and Bayesian linear regression. For both methods, we used regression analyses to develop linear transformations of the FS volumes to make them more similar to the NQ volumes. The FS-to-NQ transformations based on traditional linear regression resulted in effect sizes which were small to moderate. The transformations based on Bayesian linear regression resulted in all effect sizes being trivially small. To our knowledge, this is the first report describing a method for transforming FS to NQ data so as to achieve high reliability and low effect size differences. Machine learning methods like Bayesian regression may be more useful than traditional methods. Copyright © 2018 Elsevier B.V. All rights reserved.

The Structure and Climate of Size: Small Scale Schooling in an Urban District

ERIC Educational Resources Information Center

LeChasseur, Kimberly

2009-01-01

This study explores mechanisms involved in small scale schooling and student engagement. Specifically, this study questions the validity of arguments for small scale schooling reforms that confound the promised effects of small scale schooling "structures" (such as smaller enrollments, schools-within-schools, and smaller class sizes)…

Low level of polyandry constrains phenotypic plasticity of male body size in mites.

PubMed

Schausberger, Peter; Walzer, Andreas; Murata, Yasumasa; Osakabe, Masahiro

2017-01-01

Polyandry, i.e. females mating with multiple males, is more common than previously anticipated and potentially provides both direct and indirect fitness benefits to females. The level of polyandry (defined by the lifetime number of male mates of a female) is an important determinant of the occurrence and intensity of sexual selection acting on male phenotypes. While the forces of sexual selection acting on phenotypic male traits such as body size are relatively well understood, sexual selection acting on phenotypic plasticity of these traits is unexplored. We tackled this issue by scrutinizing the link between polyandry and phenotypic plasticity of male body size in two sympatric plant-inhabiting predatory mite species, Phytoseiulus persimilis and Neoseiulus californicus. These two species are similar in life history, ecological niche requirements, mating behavior, polygyny and female body size plasticity but strikingly differ in the level of both polyandry and phenotypic plasticity of male body size (both lower in P. persimilis). We hypothesized that deviations from standard body size, i.e. the size achieved under favorable conditions, incur higher costs for males in the less polyandrous P. persimilis. To test our hypotheses, we conducted two experiments on (i) the effects of male body size on spermatophore transfer in singly mating females and (ii) the effects of mate sequence (switching the order of standard-sized and small males) on mating behavior and paternity success in doubly mating females. In P. persimilis but not N. californicus, small males transferred fewer but larger spermatophores to the females; in both species, females re-mated more likely with standard-sized following small than small following standard-sized males; in P. persimilis, first standard-sized males sired a higher proportion of offspring produced after re-mating by the female than first small males, whereas in N. californicus the paternity success of small and standard-sized males was independent of the mating sequence. Based on our results and pertinent previous studies, which showed that females of P. persimilis, but not N. californicus, prefer mating with standard-sized over small males and allow them fertilizing more eggs, the lack of interspecific difference in female body size plasticity, and the absence of any clue pointing at a role of natural selection, we suggest that the interspecific difference in male body size plasticity is sexually selected. Our study provides an indication of sexual selection constraining plasticity of male phenotypes, suggesting that the level of polyandry may be an important co-determinant of the level of phenotypic plasticity of male body size.

Low level of polyandry constrains phenotypic plasticity of male body size in mites

PubMed Central

Walzer, Andreas; Murata, Yasumasa; Osakabe, Masahiro

2017-01-01

Polyandry, i.e. females mating with multiple males, is more common than previously anticipated and potentially provides both direct and indirect fitness benefits to females. The level of polyandry (defined by the lifetime number of male mates of a female) is an important determinant of the occurrence and intensity of sexual selection acting on male phenotypes. While the forces of sexual selection acting on phenotypic male traits such as body size are relatively well understood, sexual selection acting on phenotypic plasticity of these traits is unexplored. We tackled this issue by scrutinizing the link between polyandry and phenotypic plasticity of male body size in two sympatric plant-inhabiting predatory mite species, Phytoseiulus persimilis and Neoseiulus californicus. These two species are similar in life history, ecological niche requirements, mating behavior, polygyny and female body size plasticity but strikingly differ in the level of both polyandry and phenotypic plasticity of male body size (both lower in P. persimilis). We hypothesized that deviations from standard body size, i.e. the size achieved under favorable conditions, incur higher costs for males in the less polyandrous P. persimilis. To test our hypotheses, we conducted two experiments on (i) the effects of male body size on spermatophore transfer in singly mating females and (ii) the effects of mate sequence (switching the order of standard-sized and small males) on mating behavior and paternity success in doubly mating females. In P. persimilis but not N. californicus, small males transferred fewer but larger spermatophores to the females; in both species, females re-mated more likely with standard-sized following small than small following standard-sized males; in P. persimilis, first standard-sized males sired a higher proportion of offspring produced after re-mating by the female than first small males, whereas in N. californicus the paternity success of small and standard-sized males was independent of the mating sequence. Based on our results and pertinent previous studies, which showed that females of P. persimilis, but not N. californicus, prefer mating with standard-sized over small males and allow them fertilizing more eggs, the lack of interspecific difference in female body size plasticity, and the absence of any clue pointing at a role of natural selection, we suggest that the interspecific difference in male body size plasticity is sexually selected. Our study provides an indication of sexual selection constraining plasticity of male phenotypes, suggesting that the level of polyandry may be an important co-determinant of the level of phenotypic plasticity of male body size. PMID:29190832

Problematic smartphone use: A conceptual overview and systematic review of relations with anxiety and depression psychopathology.

PubMed

Elhai, Jon D; Dvorak, Robert D; Levine, Jason C; Hall, Brian J

2017-01-01

Research literature on problematic smartphone use, or smartphone addiction, has proliferated. However, relationships with existing categories of psychopathology are not well defined. We discuss the concept of problematic smartphone use, including possible causal pathways to such use. We conducted a systematic review of the relationship between problematic use with psychopathology. Using scholarly bibliographic databases, we screened 117 total citations, resulting in 23 peer-reviewer papers examining statistical relations between standardized measures of problematic smartphone use/use severity and the severity of psychopathology. Most papers examined problematic use in relation to depression, anxiety, chronic stress and/or low self-esteem. Across this literature, without statistically adjusting for other relevant variables, depression severity was consistently related to problematic smartphone use, demonstrating at least medium effect sizes. Anxiety was also consistently related to problem use, but with small effect sizes. Stress was somewhat consistently related, with small to medium effects. Self-esteem was inconsistently related, with small to medium effects when found. Statistically adjusting for other relevant variables yielded similar but somewhat smaller effects. We only included correlational studies in our systematic review, but address the few relevant experimental studies also. We discuss causal explanations for relationships between problem smartphone use and psychopathology. Copyright © 2016 Elsevier B.V. All rights reserved.

Differential diagnosis of an unusual shoulder articular lesion in an ancient domestic dog (Canis lupus familiaris L., 1758).

PubMed

Lawler, D F; Rubin, D A; Evans, R H; Hildebolt, C F; Smith, K E; Widga, C; Martin, T J; Siegel, M; Sackman, J E; Smith, G K; Patel, T K

2013-12-01

A proximal humeral articular surface from an ancient domestic dog deliberate burial was examined during survey of small mammal bones from a prehistoric early Late Woodland archeological site. An unusual lesion on the caudolateral articular surface prompted micro-computed tomography to define detailed structure. Results indicate cortical or immature woven bone arising subchondrally, replacing normal trabeculae, extending through a breach in the cortical surface, and having sharp transition with surrounding normal bone. Organized bone within the lesion indicates that the dog lived for months-to-years following insult. Differential diagnoses initially included: sharp penetrating trauma; intrinsic or extrinsic blunt fracturing force; osteochondrosis or complication of an osteochondral lesion; unusual osteoarthritis; and neoplasia. Computed tomography ruled out normal or unusual osteoarthritis, and neoplasia. The nature and small size of the lesion, relatively small size of the dog, and lack of evidence for complicating infection, suggest against sharp penetrating trauma as a sole cause. The most plausible differential diagnoses include: uncommon fracture-producing force in a companion animal, and blunt intrinsic or extrinsic force causing fracture at a weak point, such as an early osteochondral lesion, that was obliterated by healing. Combined gross examination, micro-computed tomography, and archeological-anthropological influences facilitated refinement of differential diagnosis. Copyright © 2013 Elsevier Inc. All rights reserved.

Canalization of body size matters for lifetime reproductive success of male predatory mites (Acari: Phytoseiidae).

PubMed

Walzer, Andreas; Schausberger, Peter

2014-04-01

The adaptive canalization hypothesis predicts that highly fitness-relevant traits are canalized via past selection, resulting in low phenotypic plasticity and high robustness to environmental stress. Accordingly, we hypothesized that the level of phenotypic plasticity of male body size of the predatory mites Phytoseiulus persimilis (low plasticity) and Neoseiulus californicus (high plasticity) reflects the effects of body size variation on fitness, especially male lifetime reproductive success (LRS). We first generated small and standard-sized males of P. persimilis and N. californicus by rearing them to adulthood under limited and ample prey supply, respectively. Then, adult small and standard-sized males were provided with surplus virgin females throughout life to assess their mating and reproductive traits. Small male body size did not affect male longevity or the number of fertilized females but reduced male LRS of P. persimilis but not N. californicus . Proximately, the lower LRS of small than standard-sized P. persimilis males correlated with shorter mating durations, probably decreasing the amount of transferred sperm. Ultimately, we suggest that male body size is more strongly canalized in P. persimilis than N. californicus because deviation from standard body size has larger detrimental fitness effects in P. persimilis than N. californicus .

Combination of Cation Exchange and Quantized Ostwald Ripening for Controlling Size Distribution of Lead Chalcogenide Quantum Dots

DOE PAGES

Zhang, Changwang; Xia, Yong; Zhang, Zhiming; ...

2017-03-22

A new strategy for narrowing the size distribution of colloidal quantum dots (QDs) was developed by combining cation exchange and quantized Ostwald ripening. Medium-sized reactant CdS(e) QDs were subjected to cation exchange to form the target PbS(e) QDs, and then small reactant CdS(e) QDs were added which were converted to small PbS(e) dots via cation exchange. The small-sized ensemble of PbS(e) QDs dissolved completely rapidly and released a large amount of monomers, promoting the growth and size-focusing of the medium-sized ensemble of PbS(e) QDs. The addition of small reactant QDs can be repeated to continuously reduce the size distribution. Themore » new method was applied to synthesize PbSe and PbS QDs with extremely narrow size distributions and as a bonus they have hybrid surface passivation. In conclusion, the size distribution of prepared PbSe and PbS QDs are as low as 3.6% and 4.3%, respectively, leading to hexagonal close packing in monolayer and highly ordered three-dimensional superlattice.« less

Combination of Cation Exchange and Quantized Ostwald Ripening for Controlling Size Distribution of Lead Chalcogenide Quantum Dots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Changwang; Xia, Yong; Zhang, Zhiming

A new strategy for narrowing the size distribution of colloidal quantum dots (QDs) was developed by combining cation exchange and quantized Ostwald ripening. Medium-sized reactant CdS(e) QDs were subjected to cation exchange to form the target PbS(e) QDs, and then small reactant CdS(e) QDs were added which were converted to small PbS(e) dots via cation exchange. The small-sized ensemble of PbS(e) QDs dissolved completely rapidly and released a large amount of monomers, promoting the growth and size-focusing of the medium-sized ensemble of PbS(e) QDs. The addition of small reactant QDs can be repeated to continuously reduce the size distribution. Themore » new method was applied to synthesize PbSe and PbS QDs with extremely narrow size distributions and as a bonus they have hybrid surface passivation. In conclusion, the size distribution of prepared PbSe and PbS QDs are as low as 3.6% and 4.3%, respectively, leading to hexagonal close packing in monolayer and highly ordered three-dimensional superlattice.« less

13 CFR 121.410 - What are the size standards for SBA's Section 8(d) Subcontracting Program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... Size Eligibility Requirements for Government Procurement § 121.410 What are the size standards for SBA... Small Business Act, a concern is small for subcontracts which relate to Government procurements if it...

Evolution of larval competitiveness and associated life-history traits in response to host shifts in a seed beetle.

PubMed

Fox, C W; Messina, F J

2018-02-01

Resource competition is frequently strong among parasites that feed within small discrete resource patches, such as seeds or fruits. The properties of a host can influence the behavioural, morphological and life-history traits of associated parasites, including traits that mediate competition within the host. For seed parasites, host size may be an especially important determinant of competitive ability. Using the seed beetle, Callosobruchus maculatus, we performed replicated, reciprocal host shifts to examine the role of seed size in determining larval competitiveness and associated traits. Populations ancestrally associated with either a small host (mung bean) or a large one (cowpea) were switched to each other's host for 36 generations. Compared to control lines (those remaining on the ancestral host), lines switched from the small host to the large host evolved greater tolerance of co-occurring larvae within seeds (indicated by an increase in the frequency of small seeds yielding two adults), smaller egg size and higher fecundity. Each change occurred in the direction predicted by the traits of populations already adapted to cowpea. However, we did not observe the expected decline in adult mass following the shift to the larger host. Moreover, lines switched from the large host (cowpea) to the small host (mung bean) did not evolve the predicted increase in larval competitiveness or egg size, but did exhibit the predicted increase in body mass. Our results thus provide mixed support for the hypothesis that host size determines the evolution of competition-related traits of seed beetles. Evolutionary responses to the two host shifts were consistent among replicate lines, but the evolution of larval competition was asymmetric, with larval competitiveness evolving as predicted in one direction of host shift, but not the reverse. Nevertheless, our results indicate that switching hosts is sufficient to produce repeatable and rapid changes in the competition strategy and fitness-related traits of insect populations. © 2017 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2017 European Society For Evolutionary Biology.

Particle size analysis of sediments, soils and related particulate materials for forensic purposes using laser granulometry.

PubMed

Pye, Kenneth; Blott, Simon J

2004-08-11

Particle size is a fundamental property of any sediment, soil or dust deposit which can provide important clues to nature and provenance. For forensic work, the particle size distribution of sometimes very small samples requires precise determination using a rapid and reliable method with a high resolution. The Coulter trade mark LS230 laser granulometer offers rapid and accurate sizing of particles in the range 0.04-2000 microm for a variety of sample types, including soils, unconsolidated sediments, dusts, powders and other particulate materials. Reliable results are possible for sample weights of just 50 mg. Discrimination between samples is performed on the basis of the shape of the particle size curves and statistical measures of the size distributions. In routine forensic work laser granulometry data can rarely be used in isolation and should be considered in combination with results from other techniques to reach an overall conclusion.

The ICF Core Sets for hearing loss--researcher perspective. Part I: Systematic review of outcome measures identified in audiological research.

PubMed

Granberg, Sarah; Dahlström, Jennie; Möller, Claes; Kähäri, Kim; Danermark, Berth

2014-02-01

To review the literature in order to identify outcome measures used in research on adults with hearing loss (HL) as part of the ICF Core Sets development project, and to describe study and population characteristics of the reviewed studies. A systematic review methodology was applied using multiple databases. A comprehensive search was conducted and two search pools were created, pool I and pool II. The study population included adults (≥ 18 years of age) with HL and oral language as the primary mode of communication. 122 studies were included. Outcome measures were distinguished by 'instrument type', and 10 types were identified. In total, 246 (pool I) and 122 (pool II) different measures were identified, and only approximately 20% were extracted twice or more. Most measures were related to speech recognition. Fifty-one different questionnaires were identified. Many studies used small sample sizes, and the sex of participants was not revealed in several studies. The low prevalence of identified measures reflects a lack of consensus regarding the optimal outcome measures to use in audiology. Reflections and discussions are made in relation to small sample sizes and the lack of sex differentiation/descriptions within the included articles.

How well do the theory of reasoned action and theory of planned behaviour predict intentions and attendance at screening programmes? A meta-analysis.

PubMed

Cooke, Richard; French, David P

2008-01-01

Meta-analysis was used to quantify how well the Theories of Reasoned Action and Planned Behaviour have predicted intentions to attend screening programmes and actual attendance behaviour. Systematic literature searches identified 33 studies that were included in the review. Across the studies as a whole, attitudes had a large-sized relationship with intention, while subjective norms and perceived behavioural control (PBC) possessed medium-sized relationships with intention. Intention had a medium-sized relationship with attendance, whereas the PBC-attendance relationship was small sized. Due to heterogeneity in results between studies, moderator analyses were conducted. The moderator variables were (a) type of screening test, (b) location of recruitment, (c) screening cost and (d) invitation to screen. All moderators affected theory of planned behaviour relationships. Suggestions for future research emerging from these results include targeting attitudes to promote intention to screen, a greater use of implementation intentions in screening information and examining the credibility of different screening providers.

Computer-Delivered Interventions to Reduce College Student Drinking: A Meta-Analysis

PubMed Central

Carey, Kate B.; Scott-Sheldon, Lori A. J.; Elliott, Jennifer C.; Bolles, Jamie R.; Carey, Michael P.

2009-01-01

Aims This meta-analysis evaluates the efficacy and moderators of computer-delivered interventions (CDIs) to reduce alcohol use among college students. Methods We included 35 manuscripts with 43 separate interventions, and calculated both between-group and within-group effect sizes for alcohol consumption and alcohol-related problems. Effects sizes were calculated for short-term (≤ 5 weeks) and longer-term (≥ 6 weeks) intervals. All studies were coded for study descriptors, participant characteristics, and intervention components. Results The effects of CDIs depended on the nature of the comparison condition: CDIs reduced quantity and frequency measures relative to assessment-only controls, but rarely differed from comparison conditions that included alcohol content. Small-to-medium within-group effect sizes can be expected for CDIs at short- and longer-term follow-ups; these changes are less than or equivalent to the within-group effect sizes observed for more intensive interventions. Conclusions CDIs reduce the quantity and frequency of drinking among college students. CDIs are generally equivalent to alternative alcohol-related comparison interventions. PMID:19744139

Ultra-Compact Motor Controller

NASA Technical Reports Server (NTRS)

Townsend, William T.; Crowell, Adam; Hauptman, Traveler; Pratt, Gill Andrews

2012-01-01

This invention is an electronically commutated brushless motor controller that incorporates Hall-array sensing in a small, 42-gram package that provides 4096 absolute counts per motor revolution position sensing. The unit is the size of a miniature hockey puck, and is a 44-pin male connector that provides many I/O channels, including CANbus, RS-232 communications, general-purpose analog and digital I/O (GPIO), analog and digital Hall inputs, DC power input (18-90 VDC, 0-l0 A), three-phase motor outputs, and a strain gauge amplifier. This controller replaces air cooling with conduction cooling via a high-thermal-conductivity epoxy casting. A secondary advantage of the relatively good heat conductivity that comes with ultra-small size is that temperature differences within the controller become smaller, so that it is easier to measure the hottest temperature in the controller with fewer temperature sensors, or even one temperature sensor. Another size-sensitive design feature is in the approach to electrical noise immunity. At a very small size, where conduction paths are much shorter than in conventional designs, the ground becomes essentially isopotential, and so certain (space-consuming) electrical noise control components become unnecessary, which helps make small size possible. One winding-current sensor, applied to all of the windings in fast sequence, is smaller and wastes less power than the two or more sensors conventionally used to sense and control winding currents. An unexpected benefit of using only one current sensor is that it actually improves the precision of current control by using the "same" sensors to read each of the three phases. Folding the encoder directly into the controller electronics eliminates a great deal of redundant electronics, packaging, connectors, and hook-up wiring. The reduction of wires and connectors subtracts substantial bulk and eliminates their role in behaving as EMI (electro-magnetic interference) antennas. A shared knowledge by each motor controller of the state of all the motors in the system at 500 Hz also allows parallel processing of higher-level kinematic matrix calculations.

Meteoroid Impacts: A Competitor for Yarkovsky and YORP

NASA Astrophysics Data System (ADS)

Wiegert, Paul

2014-11-01

Meteoroids impacting an asteroid transfer linear and angular momentum to the larger body, which may change its orbit and its rotational state. The meteoroid environment of our Solar System may affect small (few meter sizes and smaller) asteroids at a level that is comparable to the Yarkovsky and Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effects.Asteroids orbiting on prograde orbits near the Earth encounter an anisotropic meteoroid environment, including a population of particles on retrograde orbits generally accepted to be material from long-period comets spiralling inwards under Poynting-Robertson drag. High relative speed (60 km/s) impacts by meteoroids provide a small effective drag force that decreases asteroid semimajor axes and which is independent of their rotation pole. This effect may exceed the Yarkovsky drift at sizes near and below one meter.The momentum content of the meteoroids themselves is small enough to neglect, but it is the momentum transport by ejecta that increases the net effective force by two orders of magnitude for impacts into bare rock surfaces: this brings the effect to a level where it is of order that due to Yarkovsky, at least for small bodies. However, the above results are sensitive to the extrapolation of laboratory microcratering experiment results to real meteoroid-asteroid collisions and need further study.Meteoroid impacts may also affect asteroid spins at a level comparable to that of YORP at sizes smaller than tens of meters. However, we conclude that recent measurements of the YORP effect have probably not been compromised, because of the targets' large sizes and because they are known or likely to be regolith-covered rather than bare rock, which decreases the efficiency of ejecta production. However, the effect of impacts increases sharply with decreasing size, and may be important for asteroids smaller than a few tens of meters in radius.

Monte Carlo-based diode design for correction-less small field dosimetry.

PubMed

Charles, P H; Crowe, S B; Kairn, T; Knight, R T; Hill, B; Kenny, J; Langton, C M; Trapp, J V

2013-07-07

Due to their small collecting volume, diodes are commonly used in small field dosimetry. However, the relative sensitivity of a diode increases with decreasing small field size. Conversely, small air gaps have been shown to cause a significant decrease in the sensitivity of a detector as the field size is decreased. Therefore, this study uses Monte Carlo simulations to look at introducing air upstream to diodes such that they measure with a constant sensitivity across all field sizes in small field dosimetry. Varying thicknesses of air were introduced onto the upstream end of two commercial diodes (PTW 60016 photon diode and PTW 60017 electron diode), as well as a theoretical unenclosed silicon chip using field sizes as small as 5 mm × 5 mm. The metric D(w,Q)/D(Det,Q) used in this study represents the ratio of the dose to a point of water to the dose to the diode active volume, for a particular field size and location. The optimal thickness of air required to provide a constant sensitivity across all small field sizes was found by plotting D(w,Q)/D(Det,Q) as a function of introduced air gap size for various field sizes, and finding the intersection point of these plots. That is, the point at which D(w,Q)/D(Det,Q) was constant for all field sizes was found. The optimal thickness of air was calculated to be 3.3, 1.15 and 0.10 mm for the photon diode, electron diode and unenclosed silicon chip, respectively. The variation in these results was due to the different design of each detector. When calculated with the new diode design incorporating the upstream air gap, k(f(clin),f(msr))(Q(clin),Q(msr)) was equal to unity to within statistical uncertainty (0.5%) for all three diodes. Cross-axis profile measurements were also improved with the new detector design. The upstream air gap could be implanted on the commercial diodes via a cap consisting of the air cavity surrounded by water equivalent material. The results for the unclosed silicon chip show that an ideal small field dosimetry diode could be created by using a silicon chip with a small amount of air above it.

Measurement of Size-dependent Dynamic Shape Factors of Quartz Particles in Two Flow Regimes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexander, Jennifer M.; Bell, David M.; Imre, D.

2016-08-02

Understanding and modeling the behavior of quartz dust particles, commonly found in the atmosphere, requires knowledge of many relevant particles properties, including particle shape. This study uses a single particle mass spectrometer, a differential mobility analyzer, and an aerosol particle mass analyzer to measure quartz aerosol particles mobility, aerodynamic, and volume equivalent diameters, mass, composition, effective density, and dynamic shape factor as a function of particle size, in both the free molecular and transition flow regimes. The results clearly demonstrate that dynamic shape factors can vary significantly as a function of particle size. For the quartz samples studied here, themore » dynamic shape factors increase with size, indicating that larger particles are significantly more aspherical than smaller particles. In addition, dynamic shape factors measured in the free-molecular (χv) and transition (χt) flow regimes can be significantly different, and these differences vary with the size of the quartz particles. For quartz, χv of small (d < 200 nm) particles is 1.25, while χv of larger particles (d ~ 440 nm) is 1.6, with a continuously increasing trend with particle size. In contrast χt, of small particles starts at 1.1 increasing slowly to 1.34 for 550 nm diameter particles. The multidimensional particle characterization approach used here goes beyond determination of average properties for each size, to provide additional information about how the particle dynamic shape factor may vary even for particles with the same mass and volume equivalent diameter.« less

Comparative analyses of basal rate of metabolism in mammals: data selection does matter.

PubMed

Genoud, Michel; Isler, Karin; Martin, Robert D

2018-02-01

Basal rate of metabolism (BMR) is a physiological parameter that should be measured under strictly defined experimental conditions. In comparative analyses among mammals BMR is widely used as an index of the intensity of the metabolic machinery or as a proxy for energy expenditure. Many databases with BMR values for mammals are available, but the criteria used to select metabolic data as BMR estimates have often varied and the potential effect of this variability has rarely been questioned. We provide a new, expanded BMR database reflecting compliance with standard criteria (resting, postabsorptive state; thermal neutrality; adult, non-reproductive status for females) and examine potential effects of differential selectivity on the results of comparative analyses. The database includes 1739 different entries for 817 species of mammals, compiled from the original sources. It provides information permitting assessment of the validity of each estimate and presents the value closest to a proper BMR for each entry. Using different selection criteria, several alternative data sets were extracted and used in comparative analyses of (i) the scaling of BMR to body mass and (ii) the relationship between brain mass and BMR. It was expected that results would be especially dependent on selection criteria with small sample sizes and with relatively weak relationships. Phylogenetically informed regression (phylogenetic generalized least squares, PGLS) was applied to the alternative data sets for several different clades (Mammalia, Eutheria, Metatheria, or individual orders). For Mammalia, a 'subsampling procedure' was also applied, in which random subsamples of different sample sizes were taken from each original data set and successively analysed. In each case, two data sets with identical sample size and species, but comprising BMR data with different degrees of reliability, were compared. Selection criteria had minor effects on scaling equations computed for large clades (Mammalia, Eutheria, Metatheria), although less-reliable estimates of BMR were generally about 12-20% larger than more-reliable ones. Larger effects were found with more-limited clades, such as sciuromorph rodents. For the relationship between BMR and brain mass the results of comparative analyses were found to depend strongly on the data set used, especially with more-limited, order-level clades. In fact, with small sample sizes (e.g. <100) results often appeared erratic. Subsampling revealed that sample size has a non-linear effect on the probability of a zero slope for a given relationship. Depending on the species included, results could differ dramatically, especially with small sample sizes. Overall, our findings indicate a need for due diligence when selecting BMR estimates and caution regarding results (even if seemingly significant) with small sample sizes. © 2017 Cambridge Philosophical Society.

A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs

PubMed Central

Sutter, Nathan B.; Bustamante, Carlos D.; Chase, Kevin; Gray, Melissa M.; Zhao, Keyan; Zhu, Lan; Padhukasahasram, Badri; Karlins, Eric; Davis, Sean; Jones, Paul G.; Quignon, Pascale; Johnson, Gary S.; Parker, Heidi G.; Fretwell, Neale; Mosher, Dana S.; Lawler, Dennis F.; Satyaraj, Ebenezer; Nordborg, Magnus; Lark, K. Gordon; Wayne, Robert K.; Ostrander, Elaine A.

2009-01-01

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs. PMID:17412960

A single IGF1 allele is a major determinant of small size in dogs.

PubMed

Sutter, Nathan B; Bustamante, Carlos D; Chase, Kevin; Gray, Melissa M; Zhao, Keyan; Zhu, Lan; Padhukasahasram, Badri; Karlins, Eric; Davis, Sean; Jones, Paul G; Quignon, Pascale; Johnson, Gary S; Parker, Heidi G; Fretwell, Neale; Mosher, Dana S; Lawler, Dennis F; Satyaraj, Ebenezer; Nordborg, Magnus; Lark, K Gordon; Wayne, Robert K; Ostrander, Elaine A

2007-04-06

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

Metalloporphyrin-based porous polymers prepared via click chemistry for size-selective adsorption of protein.

PubMed

Zhu, Dailian; Qin, Cunqi; Ao, Shanshi; Su, Qiuping; Sun, Xiying; Jiang, Tengfei; Pei, Kemei; Ni, Huagang; Ye, Peng

2018-08-01

Zinc porphyrin-based porous polymers (PPs-Zn) with different pore sizes were prepared by controlling the reaction condition of click chemistry, and the protein adsorption in PPs-Zn and the catalytic activity of immobilized enzyme were investigated. PPs-Zn-1 with 18 nm and PPS-Zn-2 with 90 nm of pore size were characterized by FTIR, NMR and nitrogen absorption experiments. The amount of adsorbed protein in PPs-Zn-1 was more than that in PPs-Zn-2 for small size proteins, such as lysozyme, lipase and bovine serum albumin (BSA). And for large size proteins including myosin and human fibrinogen (HFg), the amount of adsorbed protein in PPs-Zn-1 was less than that in PPs-Zn-2. The result indicates that the protein adsorption is size-selective in PPs-Zn. Both the protein size and the pore size have a significant effect on the amount of adsorbed protein in the PPs-Zn. Lipase and lysozyme immobilized in PPs-Zn exhibited excellent reuse stability.

Application of assisted reproduction for population management in felids: the potential and reality for conservation of small cats.

PubMed

Swanson, William F

2006-07-01

Assisted reproductive technology (ART), using the primary applied tools of AI, ET, and sperm and embryo cryopreservation, has been promoted over the past decades for its potential to conserve endangered wildlife, including felids. However, if the goal is efficient, consistent production of viable offspring for population management, then the 'potential' of ART has yet to become 'reality' for any non-domestic cat species. For the five small-sized felids (i.e., Brazilian ocelot, fishing cat, Pallas' cat, Arabian sand cat, black-footed cat) managed by Species Survival Plans (SSPs) in North American zoos, achieving this potential may be an absolute necessity if genetically viable captive populations are to be maintained into the next century. Modeling programs suggest that current SSP populations are not sustainable without periodic introduction of new founders and improved demographic parameters, including longer generation intervals and larger population sizes. ART provides the means to address each of these management challenges. In each small cat SSP species, fecal hormone metabolite assays and seminal analysis have proven useful for characterizing basal reproductive parameters, a necessary prerequisite to developing ART. Of the five SSP species, ART has been used to produce living offspring only in the ocelot, including after AI with frozen-thawed spermatozoa and following transfer of frozen-thawed IVF embryos. The true efficacy of these techniques, however, is still unknown. To improve the applicability of ART for population management, priorities for immediate research include further investigation of ovarian stimulation protocols, sperm and embryo cryopreservation methods, embryo culture systems, and fetal and neonatal viability following ART.

Fracture analysis of radial scientific instrument module registration fittings of the space telescope

NASA Technical Reports Server (NTRS)

Springfield, C. W., Jr.

1986-01-01

Various pieces of the registration fittings for the Radial Scientific instrument (SI) module of the Space Telescope were examined from a fracture mechanics point of view and deemed to be fail-safe or else have had maximum allowable flaw sizes specified for them. The results of these analyses are summarized in tabular form. In many instances the applied stress levels were so low that the threshold stress intensity factor range was never reached. In most of the others the allowable flaw sizes were large enough to be detected by visual inspection. However, for some parts, such as the flexures connecting the aluminum cover to the ball retainer in the fitting at point A, the flaw sizes were rather small. Eddy current tests are capable of detecting flaws of this size (0.022 inches x 0.1 inches), so for those which have been so tested these small flaws should represent no danger of going undetected. In every instance approximations were made to err on the conservative side. These were pointed out in the discussions of the analyses for each fitting. One conservative approximation that was not mentioned, however, is the fact that retardation was not included in the crack propagation computations.

Size-dependent Hamaker constants for silver and gold nanoparticles

NASA Astrophysics Data System (ADS)

Pinchuk, Pavlo; Jiang, Ke

2015-08-01

Hamaker-Lifshitz constants are material specific constants that are used to calculate van der Waals interaction forces between small particles in solution. Typically, these constants are size-independent and material specific. According to the Lifshitz theory, the Hamaker-Lifshitz constants can be calculated by taking integrals that include the dielectric permittivity, as a function of frequency, of the interacting particles and the medium around particles. The dielectric permittivity of interacting metal nanoparticles can be calculated using the Drude model, which is based on the assumption of motion of free conducting electrons. For bulk metals, the Drude model does not predict any sizedependence of the dielectric permittivity. However, the conducting electrons in small noble metal nanoparticles (R ~ 10nm) exhibit surface scattering, which changes the complex permittivity function. In this work, we show theoretically that scattering of the free conducting electrons inside silver and gold nanoparticles with the size of 1 - 50 nm leads to size-dependent dielectric permittivity and Hamaker-Lifshitz constants. We calculate numerically the Hamaker-Lifshitz constants for silver and gold nanoparticles with different diameters. The results of the study might be of interests for understanding colloidal stability of metal nanoparticles.

Higher reproductive success of small males and greater recruitment of large females may explain strong reversed sexual dimorphism (RSD) in the northern goshawk.

PubMed

Pérez-Camacho, L; García-Salgado, G; Rebollo, S; Martínez-Hesterkamp, S; Fernández-Pereira, J M

2015-02-01

Reversed sexual dimorphism (RSD), which occurs when the female of a species is larger than the male, is the rule for most birds of prey but the exception among other bird and mammal species. The selective pressures that favour RSD are an intriguing issue in animal ecology. Despite the large number of hypotheses proposed to explain the evolution of RSD, there is still no consensus about the mechanisms involved and whether they act on one or both sexes, mainly because few intrapopulation studies have been undertaken and few raptor species have been investigated. Using the strongly size-dimorphic northern goshawk (Accipiter gentilis L.) as a model, we studied a population with one of the highest densities of breeding pairs reported in the literature in order to understand selective pressures that may favour RSD. We evaluated life-history processes, including recruitment of adult breeders and reproductive success, and we explored the mechanisms thought to act on each sex, including hunting efficiency, diet, body condition and mate choice. We found that smaller males produced more fledglings than larger ones, but there was no relationship between size and reproductive success for females. The mean body size of female breeders was larger than that of female fledglings, but male fledglings and breeders did not differ in size. Male body size was related to the type but not to the amount of prey captured during the nestling stage. We conclude that RSD may be favoured in this goshawk population because small males tend to enjoy higher reproductive success and large females greater recruitment. Our results do not support the hypotheses that evolutionary reduction in male size is driven by hunting efficiency, at least during the nestling stage, or the hypotheses that it is driven by greater recruitment. Our findings also suggest that increase in female size is driven by recruitment, rather than by reproductive success as previously postulated.

Role of women in population.

PubMed

Srivasdava, T N

Population control through voluntary adoption of family planning is emphasized in India's family planning policy. The 1981 census figures have not shown an arresting rate of population growth. The social and attitudinal barriers to promoting the concept of the small family are great where men and women are not exposed to new ideas. The target groups for family planning include the 75% of the population residing in rural areas. The literacy rate for women in rural areas in 1971 was 18.69. Motivation is difficult unless supported by systematic education. Women play an important role in the determination of family size. Participation in social and economic activities may help to promote small family size by meeting the necessary conditions of emotional and social fulfillment of women outside the family context. Adquate education for women in rural as well as urban areas can elucidate alternatives to childbearing and enable women to appreciate the need for and use of contraception. Employment opportunities enhance women's familial decision making power through the acquisition of an alternative social and economic role, which may help them to adopt birth control practices, space their children, and limit family size. Motivational schemes may change the attitudes of a small number of families, however, greater gains could be achieved through an investment in women's education and employment.

Small Launch Vehicle Trade Space Definition: Development of a Zero Level Mass Estimation Tool with Trajectory Validation

NASA Technical Reports Server (NTRS)

Waters, Eric D.

2013-01-01

Recent high level interest in the capability of small launch vehicles has placed significant demand on determining the trade space these vehicles occupy. This has led to the development of a zero level analysis tool that can quickly determine the minimum expected vehicle gross liftoff weight (GLOW) in terms of vehicle stage specific impulse (Isp) and propellant mass fraction (pmf) for any given payload value. Utilizing an extensive background in Earth to orbit trajectory experience a total necessary delta v the vehicle must achieve can be estimated including relevant loss terms. This foresight into expected losses allows for more specific assumptions relating to the initial estimates of thrust to weight values for each stage. This tool was further validated against a trajectory model, in this case the Program to Optimize Simulated Trajectories (POST), to determine if the initial sizing delta v was adequate to meet payload expectations. Presented here is a description of how the tool is setup and the approach the analyst must take when using the tool. Also, expected outputs which are dependent on the type of small launch vehicle being sized will be displayed. The method of validation will be discussed as well as where the sizing tool fits into the vehicle design process.

DRME: Count-based differential RNA methylation analysis at small sample size scenario.

PubMed

Liu, Lian; Zhang, Shao-Wu; Gao, Fan; Zhang, Yixin; Huang, Yufei; Chen, Runsheng; Meng, Jia

2016-04-15

Differential methylation, which concerns difference in the degree of epigenetic regulation via methylation between two conditions, has been formulated as a beta or beta-binomial distribution to address the within-group biological variability in sequencing data. However, a beta or beta-binomial model is usually difficult to infer at small sample size scenario with discrete reads count in sequencing data. On the other hand, as an emerging research field, RNA methylation has drawn more and more attention recently, and the differential analysis of RNA methylation is significantly different from that of DNA methylation due to the impact of transcriptional regulation. We developed DRME to better address the differential RNA methylation problem. The proposed model can effectively describe within-group biological variability at small sample size scenario and handles the impact of transcriptional regulation on RNA methylation. We tested the newly developed DRME algorithm on simulated and 4 MeRIP-Seq case-control studies and compared it with Fisher's exact test. It is in principle widely applicable to several other RNA-related data types as well, including RNA Bisulfite sequencing and PAR-CLIP. The code together with an MeRIP-Seq dataset is available online (https://github.com/lzcyzm/DRME) for evaluation and reproduction of the figures shown in this article. Copyright © 2016 Elsevier Inc. All rights reserved.

Compact ultrahigh vacuum sample environments for x-ray nanobeam diffraction and imaging.

PubMed

Evans, P G; Chahine, G; Grifone, R; Jacques, V L R; Spalenka, J W; Schülli, T U

2013-11-01

X-ray nanobeams present the opportunity to obtain structural insight in materials with small volumes or nanoscale heterogeneity. The effective spatial resolution of the information derived from nanobeam techniques depends on the stability and precision with which the relative position of the x-ray optics and sample can be controlled. Nanobeam techniques include diffraction, imaging, and coherent scattering, with applications throughout materials science and condensed matter physics. Sample positioning is a significant mechanical challenge for x-ray instrumentation providing vacuum or controlled gas environments at elevated temperatures. Such environments often have masses that are too large for nanopositioners capable of the required positional accuracy of the order of a small fraction of the x-ray spot size. Similarly, the need to place x-ray optics as close as 1 cm to the sample places a constraint on the overall size of the sample environment. We illustrate a solution to the mechanical challenge in which compact ion-pumped ultrahigh vacuum chambers with masses of 1-2 kg are integrated with nanopositioners. The overall size of the environment is sufficiently small to allow their use with zone-plate focusing optics. We describe the design of sample environments for elevated-temperature nanobeam diffraction experiments demonstrate in situ diffraction, reflectivity, and scanning nanobeam imaging of the ripening of Au crystallites on Si substrates.

Compact ultrahigh vacuum sample environments for x-ray nanobeam diffraction and imaging

NASA Astrophysics Data System (ADS)

Evans, P. G.; Chahine, G.; Grifone, R.; Jacques, V. L. R.; Spalenka, J. W.; Schülli, T. U.

2013-11-01

X-ray nanobeams present the opportunity to obtain structural insight in materials with small volumes or nanoscale heterogeneity. The effective spatial resolution of the information derived from nanobeam techniques depends on the stability and precision with which the relative position of the x-ray optics and sample can be controlled. Nanobeam techniques include diffraction, imaging, and coherent scattering, with applications throughout materials science and condensed matter physics. Sample positioning is a significant mechanical challenge for x-ray instrumentation providing vacuum or controlled gas environments at elevated temperatures. Such environments often have masses that are too large for nanopositioners capable of the required positional accuracy of the order of a small fraction of the x-ray spot size. Similarly, the need to place x-ray optics as close as 1 cm to the sample places a constraint on the overall size of the sample environment. We illustrate a solution to the mechanical challenge in which compact ion-pumped ultrahigh vacuum chambers with masses of 1-2 kg are integrated with nanopositioners. The overall size of the environment is sufficiently small to allow their use with zone-plate focusing optics. We describe the design of sample environments for elevated-temperature nanobeam diffraction experiments demonstrate in situ diffraction, reflectivity, and scanning nanobeam imaging of the ripening of Au crystallites on Si substrates.

A new type of shotgun ammunition produces unique wound characteristics.

PubMed

Nelson, Craig L; Winston, David C

2007-01-01

The Tucson Police Department, Tucson, AZ, has begun using the Polyshok Impact Reactive Projectile (IRP), a new type of shotgun ammunition that includes a lead bead core that travels within single, plastic-encased projectile. On impact, the core is released to distribute over a small area, thereby disintegrating on impact to reduce the likelihood of exit or collateral damage on missed shots. After a brief review of shotgun slug ballistics and wound characteristics and a discussion of the mechanism of the Polyshok IRP, we report the first death in the United States from this ammunition. Findings included a single entrance wound with plastic ammunition components and small lead particles recovered from the body, the combination of which normally would suggest a close-range shooting with birdshot. However, the characteristics of this ammunition create different patterns than are found with slugs or shot, so that a medical examiner unfamiliar with the Polyshok IRP could draw inaccurate conclusions about ammunition and range of fire. Because the single projectile fired from this ammunition is composed of both plastic and lead, plastic components are likely to be found within the wound at any range of fire, unlike traditional shot or slug ammunition. Also, the small size of lead particles found spread through the wound cavity would ordinarily suggest a small-size shot, whereas the external appearance of the wound (a single entrance with no dispersion of shot) and the pattern of tissue destruction are more consistent with the patterns of injury associated with shotgun slugs.

The Effects of Grain Size and Temperature Distributions on the Formation of Interstellar Ice Mantles

NASA Astrophysics Data System (ADS)

Pauly, Tyler; Garrod, Robin T.

2016-02-01

Computational models of interstellar gas-grain chemistry have historically adopted a single dust-grain size of 0.1 micron, assumed to be representative of the size distribution present in the interstellar medium. Here, we investigate the effects of a broad grain-size distribution on the chemistry of dust-grain surfaces and the subsequent build-up of molecular ices on the grains, using a three-phase gas-grain chemical model of a quiescent dark cloud. We include an explicit treatment of the grain temperatures, governed both by the visual extinction of the cloud and the size of each individual grain-size population. We find that the temperature difference plays a significant role in determining the total bulk ice composition across the grain-size distribution, while the effects of geometrical differences between size populations appear marginal. We also consider collapse from a diffuse to a dark cloud, allowing dust temperatures to fall. Under the initial diffuse conditions, small grains are too warm to promote grain-mantle build-up, with most ices forming on the mid-sized grains. As collapse proceeds, the more abundant, smallest grains cool and become the dominant ice carriers; the large population of small grains means that this ice is distributed across many grains, with perhaps no more than 40 monolayers of ice each (versus several hundred assuming a single grain size). This effect may be important for the subsequent processing and desorption of the ice during the hot-core phase of star formation, exposing a significant proportion of the ice to the gas phase, increasing the importance of ice-surface chemistry and surface-gas interactions.

Impact of portion size and energy density on snack intake in preschool-aged children.

PubMed

Looney, Shannon M; Raynor, Hollie A

2011-03-01

The influence of dietary environmental factors on child weight status may be important in the battle against childhood obesity. Portion size and energy density are factors shown to impact entrée energy intake in children. However, the influence of these factors on child snack energy intake has not been studied. Thus, the aim of this study was to investigate the impact of portion size on intake of a lower energy-dense and higher energy-dense snack in preschool-aged children. A 2×2 crossover design (within-subject factors of portion size and energy density) was conducted on Wednesdays in a preschool setting on the University of Tennessee campus from October 2008 to November 2008. Seventeen children had complete data (age 3.8±0.6 years; 10 of 17 were female; 14 of 17 were white). Foods were applesauce (lower energy dense=0.43 kcal/g) and chocolate pudding (higher energy dense=1.19 kcal/g), and portion sizes were 150 g (small) and 300 g (large). Measures included anthropometrics, hunger, liking of foods, and caretakers' child-feeding practices using validated instruments. Mixed factorial analyses of covariance, with order controlled, analyzed gram and energy snack intake across conditions. There was no significant main effect of energy density on snack intake, but the main effect of portion size on snack intake (small portion size 84.2±30.8 kcal, large portion size 99.0±52.5 kcal; P<0.05) was significant. Results indicate increased energy intake when snacks are offered in larger portion size, regardless of energy density. Snack portion size may be an environmental strategy that can reduce excessive energy intake in children. Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

On the Structure of Cortical Microcircuits Inferred from Small Sample Sizes.

PubMed

Vegué, Marina; Perin, Rodrigo; Roxin, Alex

2017-08-30

The structure in cortical microcircuits deviates from what would be expected in a purely random network, which has been seen as evidence of clustering. To address this issue, we sought to reproduce the nonrandom features of cortical circuits by considering several distinct classes of network topology, including clustered networks, networks with distance-dependent connectivity, and those with broad degree distributions. To our surprise, we found that all of these qualitatively distinct topologies could account equally well for all reported nonrandom features despite being easily distinguishable from one another at the network level. This apparent paradox was a consequence of estimating network properties given only small sample sizes. In other words, networks that differ markedly in their global structure can look quite similar locally. This makes inferring network structure from small sample sizes, a necessity given the technical difficulty inherent in simultaneous intracellular recordings, problematic. We found that a network statistic called the sample degree correlation (SDC) overcomes this difficulty. The SDC depends only on parameters that can be estimated reliably given small sample sizes and is an accurate fingerprint of every topological family. We applied the SDC criterion to data from rat visual and somatosensory cortex and discovered that the connectivity was not consistent with any of these main topological classes. However, we were able to fit the experimental data with a more general network class, of which all previous topologies were special cases. The resulting network topology could be interpreted as a combination of physical spatial dependence and nonspatial, hierarchical clustering. SIGNIFICANCE STATEMENT The connectivity of cortical microcircuits exhibits features that are inconsistent with a simple random network. Here, we show that several classes of network models can account for this nonrandom structure despite qualitative differences in their global properties. This apparent paradox is a consequence of the small numbers of simultaneously recorded neurons in experiment: when inferred via small sample sizes, many networks may be indistinguishable despite being globally distinct. We develop a connectivity measure that successfully classifies networks even when estimated locally with a few neurons at a time. We show that data from rat cortex is consistent with a network in which the likelihood of a connection between neurons depends on spatial distance and on nonspatial, asymmetric clustering. Copyright © 2017 the authors 0270-6474/17/378498-13$15.00/0.

Small Class Size and Its Effects.

ERIC Educational Resources Information Center

Biddle, Bruce J.; Berliner, David C.

2002-01-01

Describes several prominent early grades small-class-size projects and their effects on student achievement: Indiana's Project Prime Time, Tennessee's Project STAR (Student/Teacher Achievement Ratio), Wisconsin's SAGE (Student Achievement Guarantee in Education) Program, and the California class-size-reduction program. Lists several conclusions,…

An example of population-level risk assessments for small mammals using individual-based population models.

PubMed

Schmitt, Walter; Auteri, Domenica; Bastiansen, Finn; Ebeling, Markus; Liu, Chun; Luttik, Robert; Mastitsky, Sergey; Nacci, Diane; Topping, Chris; Wang, Magnus

2016-01-01

This article presents a case study demonstrating the application of 3 individual-based, spatially explicit population models (IBMs, also known as agent-based models) in ecological risk assessments to predict long-term effects of a pesticide to populations of small mammals. The 3 IBMs each used a hypothetical fungicide (FungicideX) in different scenarios: spraying in cereals (common vole, Microtus arvalis), spraying in orchards (field vole, Microtus agrestis), and cereal seed treatment (wood mouse, Apodemus sylvaticus). Each scenario used existing model landscapes, which differed greatly in size and structural complexity. The toxicological profile of FungicideX was defined so that the deterministic long-term first tier risk assessment would result in high risk to small mammals, thus providing the opportunity to use the IBMs for risk assessment refinement (i.e., higher tier risk assessment). Despite differing internal model design and scenarios, results indicated in all 3 cases low population sensitivity unless FungicideX was applied at very high (×10) rates. Recovery from local population impacts was generally fast. Only when patch extinctions occured in simulations of intentionally high acute toxic effects, recovery periods, then determined by recolonization, were of any concern. Conclusions include recommendations for the most important input considerations, including the selection of exposure levels, duration of simulations, statistically robust number of replicates, and endpoints to report. However, further investigation and agreement are needed to develop recommendations for landscape attributes such as size, structure, and crop rotation to define appropriate regulatory risk assessment scenarios. Overall, the application of IBMs provides multiple advantages to higher tier ecological risk assessments for small mammals, including consistent and transparent direct links to specific protection goals, and the consideration of more realistic scenarios. © 2015 SETAC.

Human resource factors associated with workplace safety and health education of small manufacturing businesses in Korea.

PubMed

Park, Kyoung-Ok

2018-01-25

Human resources (HR) are essential indicators of safety and health (SH) status, and HR can be key sources of workplace safety management such as safety and health education at work (SHEW). This study analyzed significant HR factors associated with SHEW of small manufacturing businesses in Korea. The secondary data of the 2012 Korea Occupational Safety and Health Trend Survey were used to achieve this research purpose. A total of 2,089 supervisors or managers employed in the small manufacturing businesses completed the interview survey. Survey businesses were selected by multiple stratified sampling method based on industry code, business size, and region in Korea. The survey included workplace characteristics of HR and SHEW. SHEW was significantly related to business size, occupational injury incidence in the previous year, foreign and elderly worker employment, presence of site supervisors, and presence of SH committees (p <.05). SHEW for office workers, non-office workers, and newcomers was associated with business size, presence of site supervisors, and presence of SH committees in logistic regression analysis (p <.001). Businesses with 30-49 workers conducted SHEW 3.64 times more than did businesses with 5 to fewer than 10 workers. The companies that had occupational injuries in the previous year conducted SHEW 1.68 times more than the others. The businesses that had site supervisors and committees conducted SHEW 2.30 and 2.18 times more, respectively, than others. Site supervisors and SH committees were significant HR factors that improved SHEW in small manufacturing businesses.

The Small Mars System

NASA Astrophysics Data System (ADS)

Fantino, E.; Grassi, M.; Pasolini, P.; Causa, F.; Molfese, C.; Aurigemma, R.; Cimminiello, N.; de la Torre, D.; Dell'Aversana, P.; Esposito, F.; Gramiccia, L.; Paudice, F.; Punzo, F.; Roma, I.; Savino, R.; Zuppardi, G.

2017-08-01

The Small Mars System is a proposed mission to Mars. Funded by the European Space Agency, the project has successfully completed Phase 0. The contractor is ALI S.c.a.r.l., and the study team includes the University of Naples ;Federico II;, the Astronomical Observatory of Capodimonte and the Space Studies Institute of Catalonia. The objectives of the mission are both technological and scientific, and will be achieved by delivering a small Mars lander carrying a dust particle analyser and an aerial drone. The former shall perform in situ measurements of the size distribution and abundance of dust particles suspended in the Martian atmosphere, whereas the latter shall demonstrate low-altitude flight in the rarefied planetary environment. The mission-enabling technology is an innovative umbrella-like heat shield, known as IRENE, developed and patented by ALI. The mission is also a technological demonstration of the shield in the upper atmosphere of Mars. The core characteristics of SMS are the low cost (120 M€) and the small size (320 kg of wet mass at launch, 110 kg at landing), features which stand out with respect to previous Mars landers. To comply with them is extremely challenging at all levels, and sets strict requirements on the choice of the materials, the sizing of payloads and subsystems, their arrangement inside the spacecraft and the launcher's selection. In this contribution, the mission and system concept and design are illustrated and discussed. Special emphasis is given to the innovative features and to the challenges faced in the development of the work.

Media effects of experimental presentation of the ideal physique on eating disorder symptoms: a meta-analysis of laboratory studies.

PubMed

Hausenblas, Heather A; Campbell, Anna; Menzel, Jessie E; Doughty, Jessica; Levine, Michael; Thompson, J Kevin

2013-02-01

Older meta-analyses of the effects of the media's portrayal of the ideal physique have found small effects revealing that exposure to the ideal physique increases body image concerns. These meta-analyses also included correlational, quasi-experimental, and experimental studies, with limited examination of moderators and other relevant outcomes besides body image. We conducted a systematic literature search and identified 33 experimental (i.e., pre and post data for both experimental and control groups) laboratory studies examining the effects of acute exposure to the media's portrayal of the ideal physique on eating disorder symptoms (i.e., body image, positive affect, negative affect, self-esteem, anger, anxiety and depression) and the mechanisms that moderate this effect. Fourteen separate meta-analyses revealed a range of small to moderate effect sizes for change in outcomes from pre to post for both experimental and control groups. Exposure to images of the ideal physique resulted in small effect sizes for increased depression and anger and decreased self-esteem and positive affect. Moderator analyses revealed moderate effect sizes for increased depression and body dissatisfaction among high-risk participants. This meta-analysis makes it clear that media exposure of the ideal physique results in small changes in eating disorder symptoms, particularly with participants at high risk for developing an eating disorder. Further research is needed to examine the longitudinal effects of media exposure of eating disorder symptoms. Copyright © 2012 Elsevier Ltd. All rights reserved.

13 CFR 121.412 - What are the size procedures for partial small business set-asides?

Code of Federal Regulations, 2010 CFR

2010-01-01

... Requirements for Government Procurement § 121.412 What are the size procedures for partial small business set... portion of a procurement, and is not required to qualify as a small business for the unrestricted portion. ...

A functional magnetic resonance imaging assessment of small animals' phobia using virtual reality as a stimulus.

PubMed

Clemente, Miriam; Rey, Beatriz; Rodriguez-Pujadas, Aina; Breton-Lopez, Juani; Barros-Loscertales, Alfonso; Baños, Rosa M; Botella, Cristina; Alcañiz, Mariano; Avila, Cesar

2014-06-27

To date, still images or videos of real animals have been used in functional magnetic resonance imaging protocols to evaluate the brain activations associated with small animals' phobia. The objective of our study was to evaluate the brain activations associated with small animals' phobia through the use of virtual environments. This context will have the added benefit of allowing the subject to move and interact with the environment, giving the subject the illusion of being there. We have analyzed the brain activation in a group of phobic people while they navigated in a virtual environment that included the small animals that were the object of their phobia. We have found brain activation mainly in the left occipital inferior lobe (P<.05 corrected, cluster size=36), related to the enhanced visual attention to the phobic stimuli; and in the superior frontal gyrus (P<.005 uncorrected, cluster size=13), which is an area that has been previously related to the feeling of self-awareness. In our opinion, these results demonstrate that virtual stimulus can enhance brain activations consistent with previous studies with still images, but in an environment closer to the real situation the subject would face in their daily lives.

Illusory expectations can affect retrieval-monitoring accuracy.

PubMed

McDonough, Ian M; Gallo, David A

2012-03-01

The present study investigated how expectations, even when illusory, can affect the accuracy of memory decisions. Participants studied words presented in large or small font for subsequent memory tests. Replicating prior work, judgments of learning indicated that participants expected to remember large words better than small words, even though memory for these words was equivalent on a standard test of recognition memory and subjective judgments. Critically, we also included tests that instructed participants to selectively search memory for either large or small words, thereby allowing different memorial expectations to contribute to performance. On these tests we found reduced false recognition when searching memory for large words relative to small words, such that the size illusion paradoxically affected accuracy measures (d' scores) in the absence of actual memory differences. Additional evidence for the role of illusory expectations was that (a) the accuracy effect was obtained only when participants searched memory for the aspect of the stimuli corresponding to illusory expectations (size instead of color) and (b) the accuracy effect was eliminated on a forced-choice test that prevented the influence of memorial expectations. These findings demonstrate the critical role of memorial expectations in the retrieval-monitoring process. 2012 APA, all rights reserved

The Ardipithecus ramidus skull and its implications for hominid origins.

PubMed

Suwa, Gen; Asfaw, Berhane; Kono, Reiko T; Kubo, Daisuke; Lovejoy, C Owen; White, Tim D

2009-10-02

The highly fragmented and distorted skull of the adult skeleton ARA-VP-6/500 includes most of the dentition and preserves substantial parts of the face, vault, and base. Anatomical comparisons and micro-computed tomography-based analysis of this and other remains reveal pre-Australopithecus hominid craniofacial morphology and structure. The Ardipithecus ramidus skull exhibits a small endocranial capacity (300 to 350 cubic centimeters), small cranial size relative to body size, considerable midfacial projection, and a lack of modern African ape-like extreme lower facial prognathism. Its short posterior cranial base differs from that of both Pan troglodytes and P. paniscus. Ar. ramidus lacks the broad, anteriorly situated zygomaxillary facial skeleton developed in later Australopithecus. This combination of features is apparently shared by Sahelanthropus, showing that the Mio-Pliocene hominid cranium differed substantially from those of both extant apes and Australopithecus.

Investigation of critical burning of fuel droplets. [monopropellants

NASA Technical Reports Server (NTRS)

Faeth, G. M.; Chanin, S.

1974-01-01

The steady combustion characteristics of droplets were considered in combustion chamber environments at various pressures, flow conditions, and ambient oxidizer concentrations for a number of hydrocarbon fuels. Using data obtained earlier, predicted gasification rates were within + or - 30% of measurements when the correction for convection was based upon average properties between the liquid surface and the flame around the droplet. Analysis was also completed for the open loop response of monopropellant droplets, based upon earlier strand combustion results. At the limit of large droplets, where the effect of flame curvature is small, the results suggest sufficient response to provide a viable mechanism for combustion instability in the frequency and droplet size range appropriate to practical combustors. Calculations are still in progress for a broader range of droplet sizes, including conditions where active combustion effects are small.

Population size is weakly related to quantitative genetic variation and trait differentiation in a stream fish.

PubMed

Wood, Jacquelyn L A; Tezel, Defne; Joyal, Destin; Fraser, Dylan J

2015-09-01

How population size influences quantitative genetic variation and differentiation among natural, fragmented populations remains unresolved. Small, isolated populations might occupy poor quality habitats and lose genetic variation more rapidly due to genetic drift than large populations. Genetic drift might furthermore overcome selection as population size decreases. Collectively, this might result in directional changes in additive genetic variation (VA ) and trait differentiation (QST ) from small to large population size. Alternatively, small populations might exhibit larger variation in VA and QST if habitat fragmentation increases variability in habitat types. We explored these alternatives by investigating VA and QST using nine fragmented populations of brook trout varying 50-fold in census size N (179-8416) and 10-fold in effective number of breeders, Nb (18-135). Across 15 traits, no evidence was found for consistent differences in VA and QST with population size and almost no evidence for increased variability of VA or QST estimates at small population size. This suggests that (i) small populations of some species may retain adaptive potential according to commonly adopted quantitative genetic measures and (ii) populations of varying sizes experience a variety of environmental conditions in nature, however extremely large studies are likely required before any firm conclusions can be made. © 2015 The Author(s). Evolution © 2015 The Society for the Study of Evolution.

Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology.

PubMed

Huang, Erich P; Wang, Xiao-Feng; Choudhury, Kingshuk Roy; McShane, Lisa M; Gönen, Mithat; Ye, Jingjing; Buckler, Andrew J; Kinahan, Paul E; Reeves, Anthony P; Jackson, Edward F; Guimaraes, Alexander R; Zahlmann, Gudrun

2015-02-01

Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of the underlying anatomic structure or biochemical process derived from medical images. Before a quantitative imaging biomarker is accepted for use in such roles, the imaging procedure to acquire it must undergo evaluation of its technical performance, which entails assessment of performance metrics such as repeatability and reproducibility of the quantitative imaging biomarker. Ideally, this evaluation will involve quantitative summaries of results from multiple studies to overcome limitations due to the typically small sample sizes of technical performance studies and/or to include a broader range of clinical settings and patient populations. This paper is a review of meta-analysis procedures for such an evaluation, including identification of suitable studies, statistical methodology to evaluate and summarize the performance metrics, and complete and transparent reporting of the results. This review addresses challenges typical of meta-analyses of technical performance, particularly small study sizes, which often causes violations of assumptions underlying standard meta-analysis techniques. Alternative approaches to address these difficulties are also presented; simulation studies indicate that they outperform standard techniques when some studies are small. The meta-analysis procedures presented are also applied to actual [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) test-retest repeatability data for illustrative purposes. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Meta-analysis of the technical performance of an imaging procedure: Guidelines and statistical methodology

PubMed Central

Huang, Erich P; Wang, Xiao-Feng; Choudhury, Kingshuk Roy; McShane, Lisa M; Gönen, Mithat; Ye, Jingjing; Buckler, Andrew J; Kinahan, Paul E; Reeves, Anthony P; Jackson, Edward F; Guimaraes, Alexander R; Zahlmann, Gudrun

2017-01-01

Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of the underlying anatomic structure or biochemical process derived from medical images. Before a quantitative imaging biomarker is accepted for use in such roles, the imaging procedure to acquire it must undergo evaluation of its technical performance, which entails assessment of performance metrics such as repeatability and reproducibility of the quantitative imaging biomarker. Ideally, this evaluation will involve quantitative summaries of results from multiple studies to overcome limitations due to the typically small sample sizes of technical performance studies and/or to include a broader range of clinical settings and patient populations. This paper is a review of meta-analysis procedures for such an evaluation, including identification of suitable studies, statistical methodology to evaluate and summarize the performance metrics, and complete and transparent reporting of the results. This review addresses challenges typical of meta-analyses of technical performance, particularly small study sizes, which often causes violations of assumptions underlying standard meta-analysis techniques. Alternative approaches to address these difficulties are also presented; simulation studies indicate that they outperform standard techniques when some studies are small. The meta-analysis procedures presented are also applied to actual [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) test–retest repeatability data for illustrative purposes. PMID:24872353

Adaptation Genomics of a Small-Colony Variant in a Pseudomonas chlororaphis 30-84 Biofilm

PubMed Central

Dorosky, Robert J.; Han, Cliff S.; Lo, Chien-chi; Dichosa, Armand E. K.; Chain, Patrick S.; Yu, Jun Myoung; Pierson, Leland S.

2014-01-01

The rhizosphere-colonizing bacterium Pseudomonas chlororaphis 30-84 is an effective biological control agent against take-all disease of wheat. In this study, we characterize a small-colony variant (SCV) isolated from a P. chlororaphis 30-84 biofilm. The SCV exhibited pleiotropic phenotypes, including small cell size, slow growth and motility, low levels of phenazine production, and increased biofilm formation and resistance to antimicrobials. To better understand the genetic alterations underlying these phenotypes, RNA and whole-genome sequencing analyses were conducted comparing an SCV to the wild-type strain. Of the genome's 5,971 genes, transcriptomic profiling indicated that 1,098 (18.4%) have undergone substantial reprograming of gene expression in the SCV. Whole-genome sequence analysis revealed multiple alterations in the SCV, including mutations in yfiR (cyclic-di-GMP production), fusA (elongation factor), and cyoE (heme synthesis) and a 70-kb deletion. Genetic analysis revealed that the yfiR locus plays a major role in controlling SCV phenotypes, including colony size, growth, motility, and biofilm formation. Moreover, a point mutation in the fusA gene contributed to kanamycin resistance. Interestingly, the SCV can partially switch back to wild-type morphologies under specific conditions. Our data also support the idea that phenotypic switching in P. chlororaphis is not due to simple genetic reversions but may involve multiple secondary mutations. The emergence of these highly adherent and antibiotic-resistant SCVs within the biofilm might play key roles in P. chlororaphis natural persistence. PMID:25416762

Availability and Use of Workplace Supports for Health Promotion Among Employees of Small and Large Businesses.

PubMed

Dale, Ann Marie; Enke, Chris; Buckner-Petty, Skye; Hipp, James Aaron; Marx, Christine; Strickland, Jaime; Evanoff, Bradley

2018-01-01

To explore the availability and utilization of workplace health supports by employees of small and large-sized employers. Cross-sectional, telephone-based interviews collected on 16 workplace health supports for physical activity and diet. Participants selected by random-digit-dialing from 4 metropolitan areas of Missouri employees from 2012 to 2013. Two thousand fifteen working adults. We explored the availability and use of supports by employer size (<100 employees vs ≥100 employees), accounting for industry and personal factors. We examined distributions and Poisson regression models of availability for supports by employer size and by industry and use of supports by employer size and personal factors. One-fifth of the 1796 employees were employed by small-sized employers. Large employers offered more supports than small (mean: 6 vs 3), but a higher proportion of employees of small-sized employers used supports when available (59% vs 47%). The differences in offered supports between industries were not due to size alone. In regard to the determinants of participation, the personal factors of gender, age, weight, and income were associated with participation in 10 of the supports. Employer size was also associated with participation in 10 supports. No associations were found between personal factors or workplace size and participation for 3 supports. A higher proportion of employees working for smaller businesses use available supports than employees of larger businesses. Supports offered by employers should target the needs and interests of the workforce, particularly for the higher risk low-income employees.

Bottles as models: predicting the effects of varying swimming speed and morphology on size selectivity and filtering efficiency in fishes.

PubMed

Paig-Tran, E W Misty; Bizzarro, Joseph J; Strother, James A; Summers, Adam P

2011-05-15

We created physical models based on the morphology of ram suspension-feeding fishes to better understand the roles morphology and swimming speed play in particle retention, size selectivity and filtration efficiency during feeding events. We varied the buccal length, flow speed and architecture of the gills slits, including the number, size, orientation and pore size/permeability, in our models. Models were placed in a recirculating flow tank with slightly negatively buoyant plankton-like particles (~20-2000 μm) collected at the simulated esophagus and gill rakers to locate the highest density of particle accumulation. Particles were captured through sieve filtration, direct interception and inertial impaction. Changing the number of gill slits resulted in a change in the filtration mechanism of particles from a bimodal filter, with very small (≤ 50 μm) and very large (>1000 μm) particles collected, to a filter that captured medium-sized particles (101-1000 μm). The number of particles collected on the gill rakers increased with flow speed and skewed the size distribution towards smaller particles (51-500 μm). Small pore sizes (105 and 200 μm mesh size) had the highest filtration efficiencies, presumably because sieve filtration played a significant role. We used our model to make predictions about the filtering capacity and efficiency of neonatal whale sharks. These results suggest that the filtration mechanics of suspension feeding are closely linked to an animal's swimming speed and the structural design of the buccal cavity and gill slits.

Does source population size affect performance in new environments?

PubMed Central

Yates, Matthew C; Fraser, Dylan J

2014-01-01

Small populations are predicted to perform poorly relative to large populations when experiencing environmental change. To explore this prediction in nature, data from reciprocal transplant, common garden, and translocation studies were compared meta-analytically. We contrasted changes in performance resulting from transplantation to new environments among individuals originating from different sized source populations from plants and salmonids. We then evaluated the effect of source population size on performance in natural common garden environments and the relationship between population size and habitat quality. In ‘home-away’ contrasts, large populations exhibited reduced performance in new environments. In common gardens, the effect of source population size on performance was inconsistent across life-history stages (LHS) and environments. When transplanted to the same set of new environments, small populations either performed equally well or better than large populations, depending on life stage. Conversely, large populations outperformed small populations within native environments, but only at later life stages. Population size was not associated with habitat quality. Several factors might explain the negative association between source population size and performance in new environments: (i) stronger local adaptation in large populations and antagonistic pleiotropy, (ii) the maintenance of genetic variation in small populations, and (iii) potential environmental differences between large and small populations. PMID:25469166

DEM study of the size-induced segregation dynamics of a ternary-size granular mixture in the rolling-regime rotating drum

NASA Astrophysics Data System (ADS)

Yang, Shiliang; Zhang, Liangqi; Luo, Kun; Chew, Jia Wei

2017-12-01

Segregation induced by size, shape, or density difference of the granular material is inevitable in both natural and industrial processes; unfortunately, the underlying mechanism is still not fully understood. In view of the ubiquitous continuous particle size distributions, this study builds on the considerable knowledge gained so far from binary-size mixtures and extends it to a ternary-size mixture to understand the impact of the presence of a third particle size in the three-dimensional rotating drum operating in the rolling flow regime. The discrete element method is employed. The evolution of segregation, the active-passive interface, and the dynamical response of the particle-scale characteristics of the different particle types in the two regions are investigated. The results reveal that the medium particles are spatially sandwiched in between the large and small particles in both the radial and axial directions and therefore exhibit behaviors intermediate to the other two particle types. Compared to the binary-size mixture, the presence of the medium particles leads to (i) higher purity of small particles in the innermost of the radial core, causing a decrease of the translational velocity of small particles; (ii) decrease and increase of the collision forces exerted on, respectively, the large and small particles in both regions; and (iii) increase in the relative ratio of the active-passive exchange rates of small to large particles. The results obtained in the current study therefore provide valuable insights regarding the size-segregation dynamics of granular mixtures with constituents of different sizes.

NASA Near Earth Network (NEN) and Space Network (SN) CubeSat Communications

NASA Technical Reports Server (NTRS)

Schaire, Scott H.; Shaw, Harry; Altunc, Serhat; Bussey, George; Celeste, Peter; Kegege, Obadiah; Wong, Yen; Zhang, Yuwen; Patel, Chitra; Raphael, David;

Collective relaxation dynamics of small-world networks

NASA Astrophysics Data System (ADS)

Grabow, Carsten; Grosskinsky, Stefan; Kurths, Jürgen; Timme, Marc

2015-05-01

Complex networks exhibit a wide range of collective dynamic phenomena, including synchronization, diffusion, relaxation, and coordination processes. Their asymptotic dynamics is generically characterized by the local Jacobian, graph Laplacian, or a similar linear operator. The structure of networks with regular, small-world, and random connectivities are reasonably well understood, but their collective dynamical properties remain largely unknown. Here we present a two-stage mean-field theory to derive analytic expressions for network spectra. A single formula covers the spectrum from regular via small-world to strongly randomized topologies in Watts-Strogatz networks, explaining the simultaneous dependencies on network size N , average degree k , and topological randomness q . We present simplified analytic predictions for the second-largest and smallest eigenvalue, and numerical checks confirm our theoretical predictions for zero, small, and moderate topological randomness q , including the entire small-world regime. For large q of the order of one, we apply standard random matrix theory, thereby overarching the full range from regular to randomized network topologies. These results may contribute to our analytic and mechanistic understanding of collective relaxation phenomena of network dynamical systems.

NASA Near Earth Network (NEN) and Space Network (SN) Support of CubeSat Communications

NASA Technical Reports Server (NTRS)

Schaire, Scott H.; Shaw, Harry C.; Altunc, Serhat; Bussey, George; Celeste, Peter; Kegege, Obadiah; Wong, Yen; Zhang, Yuwen; Patel, Chitra; Raphael, David;

Collective relaxation dynamics of small-world networks.

PubMed

Grabow, Carsten; Grosskinsky, Stefan; Kurths, Jürgen; Timme, Marc

2015-05-01

Complex networks exhibit a wide range of collective dynamic phenomena, including synchronization, diffusion, relaxation, and coordination processes. Their asymptotic dynamics is generically characterized by the local Jacobian, graph Laplacian, or a similar linear operator. The structure of networks with regular, small-world, and random connectivities are reasonably well understood, but their collective dynamical properties remain largely unknown. Here we present a two-stage mean-field theory to derive analytic expressions for network spectra. A single formula covers the spectrum from regular via small-world to strongly randomized topologies in Watts-Strogatz networks, explaining the simultaneous dependencies on network size N, average degree k, and topological randomness q. We present simplified analytic predictions for the second-largest and smallest eigenvalue, and numerical checks confirm our theoretical predictions for zero, small, and moderate topological randomness q, including the entire small-world regime. For large q of the order of one, we apply standard random matrix theory, thereby overarching the full range from regular to randomized network topologies. These results may contribute to our analytic and mechanistic understanding of collective relaxation phenomena of network dynamical systems.

78 FR 37397 - Small Business Size Standards: Agriculture, Forestry, Fishing and Hunting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... Small Business Size Standards: Agriculture, Forestry, Fishing and Hunting AGENCY: U.S. Small Business... (NAICS) Sector 11, Agriculture, Forestry, Fishing and Hunting, and retaining the current standards for...-industries (``exceptions'') in NAICS Sector 11, Agriculture, Forestry, Fishing and Hunting, to determine...

Measured Noise from Small Unmanned Aerial Vehicles

NASA Technical Reports Server (NTRS)

Cabell, Randolph; McSwain, Robert; Grosveld, Ferdinand

2016-01-01

Proposed uses of small unmanned aerial vehicles (UAVs), including home package delivery, have the potential to expose large portions of communities to a new noise source. This paper discusses results of flyover noise measurements of four small UAVs, including an internal combustion-powered model airplane and three battery-powered multicopters. Basic noise characteristics of these vehicles are discussed, including spectral properties and sound level metrics such as sound pressure level, effective perceived noise level, and sound exposure level. The size and aerodynamic characteristics of the multicopters in particular make their flight path susceptible to atmospheric disturbances such as wind gusts. These gusts, coupled with a flight control system that varies rotor speed to maintain vehicle stability, create an unsteady acoustic signature. The spectral variations resulting from this unsteadiness are explored, in both hover and flyover conditions for the multicopters. The time varying noise, which differs from the relatively steady noise generated by large transport aircraft, may complicate the prediction of human annoyance using conventional sound level metrics.

Estimating the probability that the sample mean is within a desired fraction of the standard deviation of the true mean.

PubMed

Schillaci, Michael A; Schillaci, Mario E

2009-02-01

The use of small sample sizes in human and primate evolutionary research is commonplace. Estimating how well small samples represent the underlying population, however, is not commonplace. Because the accuracy of determinations of taxonomy, phylogeny, and evolutionary process are dependant upon how well the study sample represents the population of interest, characterizing the uncertainty, or potential error, associated with analyses of small sample sizes is essential. We present a method for estimating the probability that the sample mean is within a desired fraction of the standard deviation of the true mean using small (n<10) or very small (n < or = 5) sample sizes. This method can be used by researchers to determine post hoc the probability that their sample is a meaningful approximation of the population parameter. We tested the method using a large craniometric data set commonly used by researchers in the field. Given our results, we suggest that sample estimates of the population mean can be reasonable and meaningful even when based on small, and perhaps even very small, sample sizes.

Pouch size influences clinical outcome of pouch construction after total gastrectomy: a meta-analysis.

PubMed

Dong, Heng-Lei; Huang, Yu-Bei; Ding, Xue-Wei; Song, Feng-Ju; Chen, Ke-Xin; Hao, Xi-Shan

2014-08-07

To assess the clinical significance of pouch size in total gastrectomy for gastric malignancies. We manually searched the English-language literature in PubMed, Cochrane Library, Web of Science and BIOSIS Previews up to October 31, 2013. Only randomized control trials comparing small pouch with large pouch in gastric reconstruction after total gastrectomy were eligible for inclusion. Two reviewers independently carried out the literature search, study selection, data extraction and quality assessment of included publications. Standard mean difference (SMD) or relative risk (RR) and corresponding 95%CI were calculated as summary measures of effects. Five RCTs published between 1996 and 2011 comparing small pouch formation with large pouch formation after total gastrectomy were included. Eating capacity per meal in patients with a small pouch was significantly higher than that in patients with a large pouch (SMD = 0.85, 95%CI: 0.25-1.44, I(2) = 0, P = 0.792), and the operative time spent in the small pouch group was significantly longer than that in the large pouch group [SMD = -3.87, 95%CI: -7.68-(-0.09), I (2) = 95.6%, P = 0]. There were no significant differences in body weight at 3 mo (SMD = 1.45, 95%CI: -4.24-7.15, I(2) = 97.7%, P = 0) or 12 mo (SMD = -1.34, 95%CI: -3.67-0.99, I(2) = 94.2%, P = 0) after gastrectomy, and no significant improvement of post-gastrectomy symptoms (heartburn, RR = 0.39, 95%CI: 0.12-1.29, I(2) = 0, P = 0.386; dysphagia, RR = 0.86, 95%CI: 0.58-1.27, I(2) = 0, P = 0.435; and vomiting, RR = 0.5, 95%CI: 0.15-1.62, I(2) = 0, P = 0.981) between the two groups. Small pouch can significantly improve the eating capacity per meal after surgery, and may improve the post-gastrectomy symptoms, including heartburn, dysphagia and vomiting.

Communication. Kinetics of scavenging of small, nucleating clusters. First nucleation theorem and sum rules

DOE PAGES

Malila, Jussi; McGraw, Robert; Laaksonen, Ari; ...

2015-01-07

Despite recent advances in monitoring nucleation from a vapor at close-to-molecular resolution, the identity of the critical cluster, forming the bottleneck for the nucleation process, remains elusive. During past twenty years, the first nucleation theorem has been often used to extract the size of the critical cluster from nucleation rate measurements. However, derivations of the first nucleation theorem invoke certain questionable assumptions that may fail, e.g., in the case of atmospheric new particle formation, including absence of subcritical cluster losses and heterogeneous nucleation on pre-existing nanoparticles. Here we extend the kinetic derivation of the first nucleation theorem to give amore » general framework to include such processes, yielding sum rules connecting the size dependent particle formation and loss rates to the corresponding loss-free nucleation rate and the apparent critical size from a naïve application of the first nucleation theorem that neglects them.« less

Nonlinear Dynamical Model of a Soft Viscoelastic Dielectric Elastomer

NASA Astrophysics Data System (ADS)

Zhang, Junshi; Chen, Hualing; Li, Dichen

2017-12-01

Actuated by alternating stimulation, dielectric elastomers (DEs) show a behavior of complicated nonlinear vibration, implying a potential application as dynamic electromechanical actuators. As is well known, for a vibrational system, including the DE system, the dynamic properties are significantly affected by the geometrical sizes. In this article, a nonlinear dynamical model is deduced to investigate the geometrical effects on dynamic properties of viscoelastic DEs. The DEs with square and arbitrary rectangular geometries are considered, respectively. Besides, the effects of tensile forces on dynamic performances of rectangular DEs with comparably small and large geometrical sizes are explored. Phase paths and Poincaré maps are utilized to detect the periodicity of the nonlinear vibrations of DEs. The resonance characteristics of DEs incorporating geometrical effects are also investigated. The results indicate that the dynamic properties of DEs, including deformation response, vibrational periodicity, and resonance, are tuned when the geometrical sizes vary.

Production of monodisperse, polymeric microspheres

NASA Technical Reports Server (NTRS)

Rembaum, Alan (Inventor); Rhim, Won-Kyu (Inventor); Hyson, Michael T. (Inventor); Chang, Manchium (Inventor)

1990-01-01

Very small, individual polymeric microspheres with very precise size and a wide variation in monomer type and properties are produced by deploying a precisely formed liquid monomer droplet, suitably an acrylic compound such as hydroxyethyl methacrylate into a containerless environment. The droplet which assumes a spheroid shape is subjected to polymerizing radiation such as ultraviolet or gamma radiation as it travels through the environment. Polymeric microspheres having precise diameters varying no more than plus or minus 5 percent from an average size are recovered. Many types of fillers including magnetic fillers may be dispersed in the liquid droplet.

Inertial impaction air sampling device

DOEpatents

Dewhurst, K.H.

1990-05-22

An inertial impactor is designed which is to be used in an air sampling device for collection of respirable size particles in ambient air. The device may include a graphite furnace as the impaction substrate in a small-size, portable, direct analysis structure that gives immediate results and is totally self-contained allowing for remote and/or personal sampling. The graphite furnace collects suspended particles transported through the housing by means of the air flow system, and these particles may be analyzed for elements, quantitatively and qualitatively, by atomic absorption spectrophotometry. 3 figs.

A facile in vitro model to study rapid mineralization in bone tissues.

PubMed

Deegan, Anthony J; Aydin, Halil M; Hu, Bin; Konduru, Sandeep; Kuiper, Jan Herman; Yang, Ying

2014-09-16

Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the final calcified tissue. An in vitro model to investigate the influencing factors is highly required. We developed a facile in vitro model in which an osteoblast cell line and aggregate culture (through the modification of culture well surfaces) were used to mimic intramembranous bone mineralization. The effect of culture environments including culture duration (up to 72 hours for rapid mineralization study) and aggregates size (monolayer culture as control) on mineralization rate and mineral quantity/quality were examined by osteogenic gene expression (PCR) and mineral markers (histological staining, SEM-EDX and micro-CT). Two size aggregates (on average, large aggregates were 745 μm and small 79 μm) were obtained by the facile technique with high yield. Cells in aggregate culture generated visible and quantifiable mineralized matrix within 24 hours, whereas cells in monolayer failed to do so by 72 hours. The gene expression of important ECM molecules for bone formation including collagen type I, alkaline phosphatase, osteopontin and osteocalcin, varied temporally, differed between monolayer and aggregate cultures, and depended on aggregate size. Monolayer specimens stayed in a proliferation phase for the first 24 hours, and remained in matrix synthesis up to 72 hours; whereas the small aggregates were in the maturation phase for the first 24 and 48 hour cultures and then jumped to a mineralization phase at 72 hours. Large aggregates were in a mineralization phase at all these three time points and produced 36% larger bone nodules with a higher calcium content than those in the small aggregates after just 72 hours in culture. This study confirms that aggregate culture is sufficient to induce rapid mineralization and that aggregate size determines the mineralization rate. Mineral content depended on aggregate size and culture duration. Thus, our culture system may provide a good model to study regulation factors at different development phases of the osteoblastic lineage.

Examining the relationship between school district size and science achievement in Texas including rural school administrator perceptions of challenges and solutions

NASA Astrophysics Data System (ADS)

Mann, Matthew James

Rural and small schools have almost one-third of all public school enrollment in America, yet typically have the fewest financial and research based resources. Educational models have been developed with either the urban or suburban school in mind, and the rural school is often left with no other alternative except this paradigm. Rural based educational resources are rare and the ability to access these resources for rural school districts almost non-existent. Federal and state based education agencies provide some rural educational based programs, but have had virtually no success in answering rural school issues. With federal and state interest in science initiatives, the challenge that rural schools face weigh in. To align with that focus, this study examined Texas middle school student achievement in science and its relationship with school district enrollment size. This study involved a sequential transformative mixed methodology with the quantitative phase driving the second qualitative portion. The quantitative research was a non-experimental causal-comparative study conducted to determine whether there is a significant difference between student achievement on the 2010 Texas Assessment of Knowledge and Skills 8 th grade science results and school district enrollment size. The school districts were distributed into four categories by size including: a) small districts (32-550); b) medium districts (551-1500); c) large districts (1501-6000); and d) mega-sized districts (6001-202,773). A one-way analysis of variance (ANOVA) was conducted to compare the district averages from the 2010 TAKS 8th grade science assessment results and the four district enrollment groups. The second phase of the study was qualitative utilizing constructivism and critical theory to identify the issues facing rural and small school administrators concerning science based curriculum and development. These themes and issues were sought through a case study method and through use of semi-structured interviews with successful rural school administrators who serve campuses currently rated recognized or higher on the Texas Education Agency accountability system. The qualitative data analysis employed the coding of interviews and observations that allowed for and sought emergent themes and alternative rural perspectives.

Trading Paths: Mapping Chickasaw History in the Eighteenth Century

ERIC Educational Resources Information Center

St. Jean, Wendy

2003-01-01

Because of its small size, the Chickasaw Nation has been relegated to the margin of studies of eastern Woodlands tribes and rarely included in narratives of Southern history. This omission is regrettable because the Chickasaws were at the center of resistance to French expansion in the region. And while representative of other southeastern…

Goldilocks/Baby Bear Approach to Differentiation

ERIC Educational Resources Information Center

Oliver, Cindy Lovell

2007-01-01

The teacher's of America's one-room schoolhouses long ago mastered the concept of differentiation. Small class sizes were the norm, including children of all ages. Older, or more advanced students, helped others understand their lessons. Students move on to more difficult work as they were ready. Skipping grades was not uncommon. As the population…

A Multimodal Approach to Emotion Recognition Ability in Autism Spectrum Disorders

ERIC Educational Resources Information Center

Jones, Catherine R. G.; Pickles, Andrew; Falcaro, Milena; Marsden, Anita J. S.; Happe, Francesca; Scott, Sophie K.; Sauter, Disa; Tregay, Jenifer; Phillips, Rebecca J.; Baird, Gillian; Simonoff, Emily; Charman, Tony

2011-01-01

Background: Autism spectrum disorders (ASD) are characterised by social and communication difficulties in day-to-day life, including problems in recognising emotions. However, experimental investigations of emotion recognition ability in ASD have been equivocal, hampered by small sample sizes, narrow IQ range and over-focus on the visual modality.…

Wisconsin Library Trustee Reference Manual.

ERIC Educational Resources Information Center

Opinion Research Corp., Princeton, NJ.

This newly updated and revised expansion of the Wisconsin Library Trustee's Manual serves as a comprehensive resource and how-to guide for board members of public libraries that range in size and scope from small to large communities in both urban and rural areas. The manual includes basic information to which every Wisconsin library trustee…

Mergers, Annexations, Dissolutions

ERIC Educational Resources Information Center

Russo, Alexander

2006-01-01

Consolidations come in all shapes and sizes, including mergers, annexations and dissolutions. They do not all take place under state mandate, however. A handful of districts consolidate every year in some states like Illinois that have large numbers of small districts, many of them dual districts that serve K-8 or 9-12 in the same geographic area.…

eLearning--Theories, Design, Software and Applications

ERIC Educational Resources Information Center

Ghislandi, Patrizia, Ed.

2012-01-01

Chapters in this book include: (1) New e-Learning Environments: e-Merging Networks in the Relational Society (Blanca C. Garcia); (2) Knowledge Building in E-Learning (Xinyu Zhang and Lu Yuhao); (3) E-Learning and Desired Learning Outcomes (Ralph Palliam); (4) Innovative E-Learning Solutions and Environments for Small and Medium Sized Companies…

Links to Literature--Huge Trees, Small Drawings: Ideas of Relative Sizes.

ERIC Educational Resources Information Center

Burton, Gail

1996-01-01

Discusses a unit integrating science, mathematics, and environmental education centered around "The Great Kapok Tree," by Lynne Cherry (1990). Ratios are used to make scale drawings of trees in a rain forest. Other activities include a terrarium and problem-solving activities based on eating habits of rain forest animals. (KMC)

Modeling Reading Growth in Grades 3 to 5 with an Alternate Assessment

ERIC Educational Resources Information Center

Farley, Dan; Anderson, Daniel; Irvin, P. Shawn; Tindal, Gerald

2017-01-01

Modeling growth for students with significant cognitive disabilities (SWSCD) is difficult due to a variety of factors, including, but not limited to, missing data, test scaling, group heterogeneity, and small sample sizes. These challenges may account for the paucity of previous research exploring the academic growth of SWSCD. Our study represents…

AN EXPERIMENT IN FLEXIBLE SCHEDULING IN TEAM TEACHING.

ERIC Educational Resources Information Center

BJELKE, JOAN; GEORGIADES, WILLIAM

A FOUR-PERIOD BLOCK PROGRAM CONSISTED OF ENGLISH, ALGEBRA, AND WORLD GEOGRAPHY. THE PROGRAM INCLUDED LARGE GROUP LECTURES, SMALL GROUP DISCUSSIONS, INDEPENDENT STUDY, AND A SUPERVISED STUDY HALL. PUPIL PERFORMANCE IN ENGLISH IN THIS SCHEMA AND PUPIL PERFORMANCE IN ENGLISH IN A REGULAR-SIZED CLASS WAS COMPARED. TEACHER REACTION AND STUDENT REACTION…

Knowledge as a Resource--Networks Do Matter: A Study of SME Firms in Rural Illinois.

ERIC Educational Resources Information Center

Solymossy, Emeric

2000-01-01

Networks among people and businesses facilitate the capture and diffusion of technical and organizational knowledge and can be classified by type of knowledge being exchanged. Types include buyer-supplier information, technical problem-solving information, and informal community information. A survey of 141 small and medium-sized enterprises…

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.

PubMed

Liu, Shixuan; Ginzberg, Miriam Bracha; Patel, Nish; Hild, Marc; Leung, Bosco; Li, Zhengda; Chen, Yen-Chi; Chang, Nancy; Wang, Yuan; Tan, Ceryl; Diena, Shulamit; Trimble, William; Wasserman, Larry; Jenkins, Jeremy L; Kirschner, Marc W; Kafri, Ran

2018-03-29

Animal cells within a tissue typically display a striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown. We have previously shown that size uniformity in animal cells is promoted, in part, by size-dependent regulation of G1 length. To identify the molecular mechanisms underlying this process, we performed a large-scale small molecule screen and found that the p38 MAPK pathway is involved in coordinating cell size and cell cycle progression. Small cells display higher p38 activity and spend more time in G1 than larger cells. Inhibition of p38 MAPK leads to loss of the compensatory G1 length extension in small cells, resulting in faster proliferation, smaller cell size and increased size heterogeneity. We propose a model wherein the p38 pathway responds to changes in cell size and regulates G1 exit accordingly, to increase cell size uniformity. © 2017, Liu et al.

77 FR 28520 - Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... proposed rules provide a clear set of guidelines for small businesses to understand and a bright-line test..., bright-line test for SBIR and STTR applicants to apply when determining eligibility with respect to size... owns 33% or more of the company) in order to create a bright-line test for applicants; (2) find...

13 CFR 107.760 - How a change in size or activity of a Portfolio Concern affects the Licensee and the Portfolio...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How a change in size or activity... Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Financing of Small Businesses by Licensees Determining the Eligibility of A Small Business for Sbic Financing...

Bank Size and Small- and Medium-sized Enterprise (SME) Lending: Evidence from China.

PubMed

Shen, Yan; Shen, Minggao; Xu, Zhong; Bai, Ying

2009-04-01

Using panel data collected in 2005, we evaluate how bank size, discretion over credit, incentive schemes, competition, and the institutional environment affect lending to small- and medium-sized enterprises in China. We deal with the endogeneity problem using instrumental variables, and a reduced-form approach is also applied to allow for weak instruments in estimation. We find that total bank asset is an insignificant factor for banks' decision on small- and medium-enterprise (SME) lending, but more local lending authority, more competition, carefully designed incentive schemes, and stronger law enforcement encourage commercial banks to lend to SMEs.

The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects.

PubMed

Kotani, Kazuhiko; Tsuzaki, Kokoro; Sakane, Naoki; Taniguchi, Nobuyuki

2012-06-01

Small dense low-density lipoprotein (sdLDL), which has a small LDL particle size with a greater susceptibility to oxidation, is considered a risk marker for cardiovascular disease (CVD). The diacron reactive oxygen metabolites (d-ROMs) have recently been introduced as a clinically useful oxidative stress-related marker. Physical activity can reduce the CVD risk. The present study investigated the correlation between the changes of the mean LDL particle size and the oxidative stress status, as assessed by the d-ROMs, in a physical activity intervention in hyperlipidemic subjects. We performed a 6-month intervention study of 30 hyperlipidemic subjects (12 male/18 female, mean age 64 years), focusing on a moderate physical activity increase. The clinical data, including the atherosclerotic risk factors besides the mean LDL particle size measured with the gel electrophoresis and the d-ROMs, were evaluated pre- and post-intervention. The mean LDL particle size was significantly larger in the post-intervention than in the pre-intervention evaluation (26.9 ± 0.3 (SD) vs. 27.1 ± 0.4 nm, P < 0.01), while the d-ROMs levels were significantly reduced in the post-intervention period compared to those at pre-intervention (319 ± 77 vs. 290 ± 73 U. Carr., P < 0.05). A stepwise multiple regression analysis revealed that there was an independent, significant and inverse correlation between the pre- and post-intervention changes of the d-ROMs and the mean LDL particle size (β = -0.55, P < 0.01). The intervention study suggests that sdLDL and oxidative stress can concomitantly affect the risk of developing CVD and that both factors can improve by even a moderate increase in physical activity among hyperlipidemic subjects.

OsMAPK6, a mitogen-activated protein kinase, influences rice grain size and biomass production.

PubMed

Liu, Shuying; Hua, Lei; Dong, Sujun; Chen, Hongqi; Zhu, Xudong; Jiang, Jun'e; Zhang, Fang; Li, Yunhai; Fang, Xiaohua; Chen, Fan

2015-11-01

Grain size is an important agronomic trait in determining grain yield. However, the molecular mechanisms that determine the final grain size are not well understood. Here, we report the functional analysis of a rice (Oryza sativa L.) mutant, dwarf and small grain1 (dsg1), which displays pleiotropic phenotypes, including small grains, dwarfism and erect leaves. Cytological observations revealed that the small grain and dwarfism of dsg1 were mainly caused by the inhibition of cell proliferation. Map-based cloning revealed that DSG1 encoded a mitogen-activated protein kinase (MAPK), OsMAPK6. OsMAPK6 was mainly located in the nucleus and cytoplasm, and was ubiquitously distributed in various organs, predominately in spikelets and spikelet hulls, consistent with its role in grain size and biomass production. As a functional kinase, OsMAPK6 interacts strongly with OsMKK4, indicating that OsMKK4 is likely to be the upstream MAPK kinase of OsMAPK6 in rice. In addition, hormone sensitivity tests indicated that the dsg1 mutant was less sensitive to brassinosteroids (BRs). The endogenous BR levels were reduced in dsg1, and the expression of several BR signaling pathway genes and feedback-inhibited genes was altered in the dsg1 mutant, with or without exogenous BRs, indicating that OsMAPK6 may contribute to influence BR homeostasis and signaling. Thus, OsMAPK6, a MAPK, plays a pivotal role in grain size in rice, via cell proliferation, and BR signaling and homeostasis. © 2015 The Authors The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

Sex-biased sound symbolism in english-language first names.

PubMed

Pitcher, Benjamin J; Mesoudi, Alex; McElligott, Alan G

2013-01-01

Sexual selection has resulted in sex-based size dimorphism in many mammals, including humans. In Western societies, average to taller stature men and comparatively shorter, slimmer women have higher reproductive success and are typically considered more attractive. This size dimorphism also extends to vocalisations in many species, again including humans, with larger individuals exhibiting lower formant frequencies than smaller individuals. Further, across many languages there are associations between phonemes and the expression of size (e.g. large /a, o/, small /i, e/), consistent with the frequency-size relationship in vocalisations. We suggest that naming preferences are a product of this frequency-size relationship, driving male names to sound larger and female names smaller, through sound symbolism. In a 10-year dataset of the most popular British, Australian and American names we show that male names are significantly more likely to contain larger sounding phonemes (e.g. "Thomas"), while female names are significantly more likely to contain smaller phonemes (e.g. "Emily"). The desire of parents to have comparatively larger, more masculine sons, and smaller, more feminine daughters, and the increased social success that accompanies more sex-stereotyped names, is likely to be driving English-language first names to exploit sound symbolism of size in line with sexual body size dimorphism.

Sex-Biased Sound Symbolism in English-Language First Names

PubMed Central

Pitcher, Benjamin J.; Mesoudi, Alex; McElligott, Alan G.

2013-01-01

Sexual selection has resulted in sex-based size dimorphism in many mammals, including humans. In Western societies, average to taller stature men and comparatively shorter, slimmer women have higher reproductive success and are typically considered more attractive. This size dimorphism also extends to vocalisations in many species, again including humans, with larger individuals exhibiting lower formant frequencies than smaller individuals. Further, across many languages there are associations between phonemes and the expression of size (e.g. large /a, o/, small /i, e/), consistent with the frequency-size relationship in vocalisations. We suggest that naming preferences are a product of this frequency-size relationship, driving male names to sound larger and female names smaller, through sound symbolism. In a 10-year dataset of the most popular British, Australian and American names we show that male names are significantly more likely to contain larger sounding phonemes (e.g. “Thomas”), while female names are significantly more likely to contain smaller phonemes (e.g. “Emily”). The desire of parents to have comparatively larger, more masculine sons, and smaller, more feminine daughters, and the increased social success that accompanies more sex-stereotyped names, is likely to be driving English-language first names to exploit sound symbolism of size in line with sexual body size dimorphism. PMID:23755148

Monitoring, analysis and classification of vegetation and soil data collected by a small and lightweight hyperspectral imaging system

NASA Astrophysics Data System (ADS)

Mönnig, Carsten

2014-05-01

The increasing precision of modern farming systems requires a near-real-time monitoring of agricultural crops in order to estimate soil condition, plant health and potential crop yield. For large sized agricultural plots, satellite imagery or aerial surveys can be used at considerable costs and possible time delays of days or even weeks. However, for small to medium sized plots, these monitoring approaches are cost-prohibitive and difficult to assess. Therefore, we propose within the INTERREG IV A-Project SMART INSPECTORS (Smart Aerial Test Rigs with Infrared Spectrometers and Radar), a cost effective, comparably simple approach to support farmers with a small and lightweight hyperspectral imaging system to collect remotely sensed data in spectral bands in between 400 to 1700nm. SMART INSPECTORS includes the whole remote sensing processing chain of small scale remote sensing from sensor construction, data processing and ground truthing for analysis of the results. The sensors are mounted on a remotely controlled (RC) Octocopter, a fixed wing RC airplane as well as on a two-seated Autogyro for larger plots. The high resolution images up to 5cm on the ground include spectra of visible light, near and thermal infrared as well as hyperspectral imagery. The data will be analyzed using remote sensing software and a Geographic Information System (GIS). The soil condition analysis includes soil humidity, temperature and roughness. Furthermore, a radar sensor is envisaged for the detection of geomorphologic, drainage and soil-plant roughness investigation. Plant health control includes drought stress, vegetation health, pest control, growth condition and canopy temperature. Different vegetation and soil indices will help to determine and understand soil conditions and plant traits. Additional investigation might include crop yield estimation of certain crops like apples, strawberries, pasture land, etc. The quality of remotely sensed vegetation data will be tested with ground truthing tools like a spectrometer, visual inspection and ground control panel. The soil condition will also be monitored with a wireless sensor network installed on the examined plots of interest. Provided with this data, a farmer can respond immediately to potential threats with high local precision. In this presentation, preliminary results of hyperspectral images of distinctive vegetation cover and soil on different pasture test plots are shown. After an evaluation period, the whole processing chain will offer farmers a unique, near real- time, low cost solution for small to mid-sized agricultural plots in order to easily assess crop and soil quality and the estimation of harvest. SMART INSPECTORS remotely sensed data will form the basis for an input in a decision support system which aims to detect crop related issues in order to react quickly and efficiently, saving fertilizer, water or pesticides.

Farm Safety Practices and Farm Size in New South Wales.

PubMed

Bailey, Jannine; Dutton, Tegan; Payne, Kristy; Wilson, Ross; Brew, Bronwyn K

2017-01-01

There is some evidence to suggest that safety on small-area farms may not be high priority due to economic constraints and lack of knowledge. This has important ramifications for injury and economic burden. The objective of this research was to conduct a pilot study to investigate whether small- to medium-area farms implement fewer safety practices than large-area farms. Farmers were recruited from farm safety training days, field days, and produce stores in rural New South Wales (NSW), Australia. Small- and medium-area farms less than 500 ha (1235 acres) in size were aggregated for analysis and compared with large-area farms (≥500 ha) for survey items, including safety equipment owned and used, safety practices protecting children, barriers to improving safety, and causes of injury. Overall, small/medium-area farms were found to own less safety equipment and to employ less safety practices than large-area farms. In particular, fewer tractors were fitted with rollover protection structures, there was less signage, less hearing protection, and fewer machinery guides. Injury rates were slightly less for small/medium-area farms, particularly involving vehicles. Small- and medium-area farmers were more likely to report lack of skills as barriers to making safety improvements. This pilot study found some evidence that small/medium-area farms implement fewer safety practices than large-area farms. A larger study is warranted to investigate this further, with particular focus on barriers and ways to overcome them. This could have important ramifications for government policies supporting struggling farmers on small/medium-area farms.

Multiple origins of gigantism in stem baleen whales

NASA Astrophysics Data System (ADS)

Tsai, Cheng-Hsiu; Kohno, Naoki

2016-12-01

Living baleen whales (Mysticeti) include the world's largest animals to have ever lived—blue whales ( Balaenoptera musculus) can reach more than 30 m. However, the gigantism in baleen whales remains little explored. Here, we compiled all published stem mysticetes from the Eocene and Oligocene and then mapped the estimated body size onto different phylogenies that suggest distinct evolutionary histories of baleen whales. By assembling all known stem baleen whales, we present three novel findings in early mysticete evolution. Results show that, regardless of different phylogenetic scenarios, large body size (more than 5-m long) evolved multiple times independently in their early evolutionary history. For example, the earliest known aetiocetid ( Fucaia buelli, 33-31 Ma) was small in size, about 2 m, and a later aetiocetid ( Morawanocetus-like animal, 26-23 Ma) can reach 8-m long—almost four times the size of Fucaia buelli—suggesting an independent gigantism in the aetiocetid lineage. In addition, our reconstruction of ancestral state demonstrates that the baleen whales originated from small body size (less than 5 m) rather than large body size as previously acknowledged. Moreover, reconstructing the evolution of body size in stem baleen whales suggests that the initial pulse of mysticete gigantism started at least back to the Paleogene and in turn should help to understand the origin, pattern, and process of the extreme gigantism in the crown baleen whales. This study illustrates that Cope's rule is insufficient to explain the evolution of body size in a group that comprises the largest animals in the history of life, although currently the lack of exact ancestor-descendant relationships remains to fully reveal the evolutionary history of body size.

Size effects in olivine control strength in low-temperature plasticity regime

NASA Astrophysics Data System (ADS)

Kumamoto, K. M.; Thom, C.; Wallis, D.; Hansen, L. N.; Armstrong, D. E. J.; Goldsby, D. L.; Warren, J. M.; Wilkinson, A. J.

2017-12-01

The strength of the lithospheric mantle during deformation by low-temperature plasticity controls a range of geological phenomena, including lithospheric-scale strain localization, the evolution of friction on deep seismogenic faults, and the flexure of tectonic plates. However, constraints on the strength of olivine in this deformation regime are difficult to obtain from conventional rock-deformation experiments, and previous results vary considerably. We demonstrate via nanoindentation that the strength of olivine in the low-temperature plasticity regime is dependent on the length-scale of the test, with experiments on smaller volumes of material exhibiting larger yield stresses. This "size effect" has previously been explained in engineering materials as a result of the role of strain gradients and associated geometrically necessary dislocations in modifying plastic behavior. The Hall-Petch effect, in which a material with a small grain size exhibits a higher strength than one with a large grain size, is thought to arise from the same mechanism. The presence of a size effect resolves discrepancies among previous experimental measurements of olivine, which were either conducted using indentation methods or were conducted on polycrystalline samples with small grain sizes. An analysis of different low-temperature plasticity flow laws extrapolated to room temperature reveals a power-law relationship between length-scale (grain size for polycrystalline deformation and contact radius for indentation tests) and yield strength. This suggests that data from samples with large inherent length scales best represent the plastic strength of the coarse-grained lithospheric mantle. Additionally, the plastic deformation of nanometer- to micrometer-sized asperities on fault surfaces may control the evolution of fault roughness due to their size-dependent strength.

Multiple origins of gigantism in stem baleen whales.

PubMed

Tsai, Cheng-Hsiu; Kohno, Naoki

2016-12-01

Living baleen whales (Mysticeti) include the world's largest animals to have ever lived-blue whales (Balaenoptera musculus) can reach more than 30 m. However, the gigantism in baleen whales remains little explored. Here, we compiled all published stem mysticetes from the Eocene and Oligocene and then mapped the estimated body size onto different phylogenies that suggest distinct evolutionary histories of baleen whales. By assembling all known stem baleen whales, we present three novel findings in early mysticete evolution. Results show that, regardless of different phylogenetic scenarios, large body size (more than 5-m long) evolved multiple times independently in their early evolutionary history. For example, the earliest known aetiocetid (Fucaia buelli, 33-31 Ma) was small in size, about 2 m, and a later aetiocetid (Morawanocetus-like animal, 26-23 Ma) can reach 8-m long-almost four times the size of Fucaia buelli-suggesting an independent gigantism in the aetiocetid lineage. In addition, our reconstruction of ancestral state demonstrates that the baleen whales originated from small body size (less than 5 m) rather than large body size as previously acknowledged. Moreover, reconstructing the evolution of body size in stem baleen whales suggests that the initial pulse of mysticete gigantism started at least back to the Paleogene and in turn should help to understand the origin, pattern, and process of the extreme gigantism in the crown baleen whales. This study illustrates that Cope's rule is insufficient to explain the evolution of body size in a group that comprises the largest animals in the history of life, although currently the lack of exact ancestor-descendant relationships remains to fully reveal the evolutionary history of body size.

The impact of image-size manipulation and sugar content on children's cereal consumption.

PubMed

Neyens, E; Aerts, G; Smits, T

2015-12-01

Previous studies have demonstrated that portion sizes and food energy-density influence children's eating behavior. However, the potential effects of front-of-pack image-sizes of serving suggestions and sugar content have not been tested. Using a mixed experimental design among young children, this study examines the effects of image-size manipulation and sugar content on cereal and milk consumption. Children poured and consumed significantly more cereal and drank significantly more milk when exposed to a larger sized image of serving suggestion as compared to a smaller image-size. Sugar content showed no main effects. Nevertheless, cereal consumption only differed significantly between small and large image-sizes when sugar content was low. An advantage of this study was the mundane setting in which the data were collected: a school's dining room instead of an artificial lab. Future studies should include a control condition, with children eating by themselves to reflect an even more natural context. Copyright © 2015 Elsevier Ltd. All rights reserved.

Lipoprotein profile assessed by 2D-1H-NMR and subclinical atherosclerosis in children with familial hypercholesterolaemia.

PubMed

Rodríguez-Borjabad, Cèlia; Ibarretxe, Daiana; Girona, Josefa; Ferré, Raimon; Feliu, Albert; Amigó, Núria; Guijarro, Eugenio; Masana, Luis; Plana, Núria

2018-03-01

Familial hypercholesterolaemia (FH) is underdiagnosed in children. In addition to lipid concentrations, lipoprotein particle quantity and quality could influence cardiovascular risk. We aimed to perform a comprehensive plasma lipid study, including lipoprotein particle number and size assessment by two-dimensional nuclear magnetic resonance (2D-1H-NMR), in children with FH compared to non-affected children and to evaluate the clinical value of these factors as subclinical atherosclerosis biomarkers. One hundred eighty-three children participating in the broad "Hypercholesterolemia Early Detection Programme" (Decopin Project) were recruited. They were categorized as FH, if they had either a positive genetic test or clinical certainty, or as control children (CCh). Medical history, anthropometry and clinical variables were recorded. Standard biochemical measurements were performed. The lipoprotein profile was studied by 2D-1H-NMR. Carotid intima-media thickness (cIMT) was assessed by sonography in 177 children. FH children had a significant 36% increase in LDL particles. The small LDL fraction was increased by 33% compared to CCh. The relative relationship between large, medium and small LDL and the mean LDL particle size was similar between FH children and CCh. The total and small LDL particle numbers were directly associated with and contributed to the determination of the mean cIMT according to bivariate and multivariate analyses in FH children. The higher cholesterol levels of FH children are due to an overall increased number of all LDL particle subclasses, including a notable 33% increase in small LDL. Total and small LDL particle number shows a good correlation with cIMT in FH children. Copyright © 2018 Elsevier B.V. All rights reserved.

Microreactor System Design for a NASA In Situ Propellant Production Plant on Mars

NASA Technical Reports Server (NTRS)

TeGrotenhuis, W. E.; Wegeng, R. S.; Vanderwiel, D. P.; Whyatt, G. A.; Viswanathan, V. V.; Schielke, K. P.; Sanders, G. B.; Peters, T. A.; Nicholson, Leonard S. (Technical Monitor)

2000-01-01

The NASA In Situ Resource Utilization (ISRU) program is planning near-term missions to Mars that will include chemical processes for converting the carbon dioxide (CO2) and possibly water from the Martian environment to propellants, oxygen, and other useful chemicals. The use of indigenous resources reduces the size and weight of the payloads from Earth significantly, representing enormous cost savings that make human exploration of Mars affordable. Extraterrestrial chemical processing plants will need to be compact, lightweight, highly efficient under reduced gravity, and extraordinarily reliable for long periods. Microchemical and thermal systems represent capability for dramatic reduction in size and weight, while offering high reliability through massive parallelization. In situ propellant production (ISPP), one aspect of the ISRU program, involves collecting and pressurizing atmospheric CO2, conversion reactions, chemical separations, heat exchangers, and cryogenic storage. A preliminary system design of an ISPP plant based on microtechnology has demonstrated significant size, weight, and energy efficiency gains over the current NASA baseline. Energy management is a strong driver for Mars-based processes, not only because energy is a scarce resource, but because heat rejection is problematic; the low pressure environment makes convective heat transfer ineffective. Energy efficiency gains are largely achieved in the microchemical plant through extensive heat recuperation and energy cascading, which has a small size and weight penalty because the added micro heat exchangers are small. This leads to additional size and weight gains by reducing the required area of waste heat radiators. The microtechnology-based ISPP plant is described in detail, including aspects of pinch analysis for optimizing the heat exchanger network. Three options for thermochemical compression Of CO2 from the Martian atmosphere, adsorption, absorption, and cryogenic freezing, are presented, as well as three options for water decomposition, low temperature electrolysis, high temperature electrolysis, and thermochemical decomposition. Other elements of the plant include Sabatier and reverse water gas shift reactors, water recovery, chemical separations, and cryogenic storage. Data are presented supporting preliminary sizing of components, and results of the system design are compared to the existing NASA baseline that is based on conventional technologies.

13 CFR 121.703 - Are formal size determinations binding on parties?

Code of Federal Regulations, 2010 CFR

2010-01-01

... for the Small Business Innovation Research (sbir) Program § 121.703 Are formal size determinations... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Are formal size determinations binding on parties? 121.703 Section 121.703 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION...

Modeling Physical Processes at the Nanoscale—Insight into Self-Organization of Small Systems (abstract)

NASA Astrophysics Data System (ADS)

Proykova, Ana

2009-04-01

Essential contributions have been made in the field of finite-size systems of ingredients interacting with potentials of various ranges. Theoretical simulations have revealed peculiar size effects on stability, ground state structure, phases, and phase transformation of systems confined in space and time. Models developed in the field of pure physics (atomic and molecular clusters) have been extended and successfully transferred to finite-size systems that seem very different—small-scale financial markets, autoimmune reactions, and social group reactions to advertisements. The models show that small-scale markets diverge unexpectedly fast as a result of small fluctuations; autoimmune reactions are sequences of two discontinuous phase transitions; and social groups possess critical behavior (social percolation) under the influence of an external field (advertisement). Some predicted size-dependent properties have been experimentally observed. These findings lead to the hypothesis that restrictions on an object's size determine the object's total internal (configuration) and external (environmental) interactions. Since phases are emergent phenomena produced by self-organization of a large number of particles, the occurrence of a phase in a system containing a small number of ingredients is remarkable.

The Lack of Small Craters on Eros is not due to the Yarkovsky Effect

NASA Astrophysics Data System (ADS)

O'Brien, David P.; Greenberg, R.

2007-10-01

Eros approaches saturation for craters larger than 200 m in diameter, but is significantly depleted in smaller craters [1]. It has been suggested that this could reflect a paucity of small impactors in the main belt, due to their removal by the Yarkovsky effect [1,2]. Here we present the results of a self-consistent collisional and dynamical evolution model for the main belt and NEAs, along with a model for the evolution of asteroid crater populations, that show that Eros' lack of small craters is not likely due to the depletion of small impactors by the Yarkovsky effect, or any other depletion mechanism. To produce a main-belt size distribution that is suitably depleted in small impactors to match Eros' small crater population requires a more extreme size-dependent removal rate than the Yarkovsky effect and Poynting-Robertson drag can provide. Using such an extreme removal rate introduces a wave into the model main-belt size distribution that propagates to large sizes, and is inconsistent with the observed main-belt population. Similarly, it introduces a wave in the model NEA population that is inconsistent with the observed NEAs. Eros is not alone in showing a depletion of small craters. Recent observations of the asteroid Itokawa by the Hyabusa spacecraft show relatively few craters, and Yarkovsky depletion of small impactors has again been suggested as a possible explanation [3]. Our work shows that a substantial depletion of small impactors from the main belt would have consequences at large sizes, inconsistent with observations of the actual main-belt and NEA size distributions. Other explanations for the depletion of small craters on asteroid surfaces must be explored [eg. 4,5]. References: [1] Chapman (2002), Icarus 155, p.104. [2] Bell (2001), LPSC XXXII, no.1964. [3] Saito (2006), Science 312, p.1341. [4] Richardson (2004), Science 306, p.1526. [5] Greenberg (2003), DPS 35, no.24.06.

Standard Deviation for Small Samples

ERIC Educational Resources Information Center

Joarder, Anwar H.; Latif, Raja M.

2006-01-01

Neater representations for variance are given for small sample sizes, especially for 3 and 4. With these representations, variance can be calculated without a calculator if sample sizes are small and observations are integers, and an upper bound for the standard deviation is immediate. Accessible proofs of lower and upper bounds are presented for…

76 FR 63509 - Small Business Size Standards: Administrative and Support, Waste Management and Remediation Services

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... Small Business Size Standards: Administrative and Support, Waste Management and Remediation Services... Standards: Administrative and Support, Waste Management and Remediation Services AGENCY: U.S. Small Business...) Sector 56, Administrative and Support, Waste Management and Remediation Services. As part of its ongoing...

Outcomes of transurethral resection of the prostate in benign prostatic hyperplasia comparing prostate size of more than 80 grams to prostate size less than 80 grams.

PubMed

Joshi, H N; De Jong, I J; Karmacharya, R M; Shrestha, B; Shrestha, R

2014-01-01

Benign prostatic hyperplasia is a condition occurring in elderly men in which the prostate gland is enlarged, hence the condition also known as benign enlargement of prostate. Benign hyperplasia can lead to both obstructive and irritative symptoms. Transurethral resection of prostate (TURP) still remains the gold standard modality of surgical treatment of obstructive lower urinary tract symptoms due to Benign hyperplasia. The objective of this study was to evaluate the outcomes of TURP in large prostate (>80 grams) in comparison to small prostate (<80 grams) in terms of efficacy, safety and complications. A total of 65 cases included in this prospective study, which were operated by a single surgeon with conventional monopolar TURP using standard technique. Intra -operative and post-operative complications, pre and post- operative quality of life (QoL) and international prostate symptom score (IPSS), operative time, time to removal of catheter and hospital stay were evaluated between small and large prostate gland volumes. Out of 65 cases, 30 were with large prostate size i.e. 80 grams or more (group 1), and 35 cases were with small prostate size than 80 grams size (group 2). Mean age was 71.8 SD ± 6.9 years in group 1 and 68.2 SD ± 12.7 years in group 2. The mean preoperative volume of prostate was 88.8 grams (range 80-115 grams) in group 1 and 40.3 (range 20-65 grams) in group 2. The mean preoperative post void residual volume of urine (PVRU) was 244 ml SD ± 190.8 ml in group 1 and 117 ml ± 70.3 ml in group 2. Mean resection time in group 1 was 110 (range 90-130) minutes and in group 2 it was 90 minutes (range 55-115) minutes. There were quite satisfactory improvements in IPSS and QoL. No significant complications were observed except TUR syndrome in 2 cases from group 2, which were managed well in postoperative period. With meticulous resection and intra-operative haemostasis using continuous out flow resectoscope, conventional monopolar TURP is equally safe and effective in large size prostate as compare in small size.

Small or far away? Size and distance perception in the praying mantis

PubMed Central

Bissianna, Geoffrey

2016-01-01

Stereo or ‘3D’ vision is an important but costly process seen in several evolutionarily distinct lineages including primates, birds and insects. Many selective advantages could have led to the evolution of stereo vision, including range finding, camouflage breaking and estimation of object size. In this paper, we investigate the possibility that stereo vision enables praying mantises to estimate the size of prey by using a combination of disparity cues and angular size cues. We used a recently developed insect 3D cinema paradigm to present mantises with virtual prey having differing disparity and angular size cues. We predicted that if they were able to use these cues to gauge the absolute size of objects, we should see evidence for size constancy where they would strike preferentially at prey of a particular physical size, across a range of simulated distances. We found that mantises struck most often when disparity cues implied a prey distance of 2.5 cm; increasing the implied distance caused a significant reduction in the number of strikes. We, however, found no evidence for size constancy. There was a significant interaction effect of the simulated distance and angular size on the number of strikes made by the mantis but this was not in the direction predicted by size constancy. This indicates that mantises do not use their stereo vision to estimate object size. We conclude that other selective advantages, not size constancy, have driven the evolution of stereo vision in the praying mantis. This article is part of the themed issue ‘Vision in our three-dimensional world’. PMID:27269605

Reflective small angle electron scattering to characterize nanostructures on opaque substrates

NASA Astrophysics Data System (ADS)

Friedman, Lawrence H.; Wu, Wen-Li; Fu, Wei-En; Chien, Yunsan

2017-09-01

Feature sizes in integrated circuits (ICs) are often at the scale of 10 nm and are ever shrinking. ICs appearing in today's computers and hand held devices are perhaps the most prominent examples. These smaller feature sizes demand equivalent advances in fast and accurate dimensional metrology for both development and manufacturing. Techniques in use and continuing to be developed include X-ray based techniques, optical scattering, and of course the electron and scanning probe microscopy techniques. Each of these techniques has their advantages and limitations. Here, the use of small angle electron beam scattering measurements in a reflection mode (RSAES) to characterize the dimensions and the shape of nanostructures on flat and opaque substrates is demonstrated using both experimental and theoretical evidence. In RSAES, focused electrons are scattered at angles smaller than 1 ° with the assistance of electron optics typically used in transmission electron microscopy. A proof-of-concept experiment is combined with rigorous electron reflection simulations to demonstrate the efficiency and accuracy of RSAES as a method of non-destructive measurement of shapes of features less than 10 nm in size on flat and opaque substrates.

Reflective Small Angle Electron Scattering to Characterize Nanostructures on Opaque Substrates.

PubMed

Friedman, Lawrence H; Wu, Wen-Li; Fu, Wei-En; Chien, Yunsan

2017-09-01

Features sizes in integrated circuits (ICs) are often at the scale of 10 nm and are ever shrinking. ICs appearing in today's computers and hand held devices are perhaps the most prominent examples. These smaller feature sizes demand equivalent advances in fast and accurate dimensional metrology for both development and manufacturing. Techniques in use and continuing to be developed include X-ray based techniques, optical scattering and of course the electron and scanning probe microscopy techniques. Each of these techniques have their advantages and limitations. Here the use of small angle electron beam scattering measurements in a reflection mode (RSAES) to characterize the dimensions and the shape of nanostructures on flat and opaque substrates is demonstrated using both experimental and theoretical evidence. In RSAES, focused electrons are scattered at angles smaller than 1° with the assistance of electron optics typically used in transmission electron microscopy. A proof-of-concept experiment is combined with rigorous electron reflection simulations to demonstrate the efficiency and accuracy of RSAES as a method of non-destructive measurement of shapes of features less than 10 nm in size on flat and opaque substrates.

Growing the terrestrial planets from the gradual accumulation of submeter-sized objects

PubMed Central

Levison, Harold F.; Kretke, Katherine A.; Walsh, Kevin J.; Bottke, William F.

2015-01-01

Building the terrestrial planets has been a challenge for planet formation models. In particular, classical theories have been unable to reproduce the small mass of Mars and instead predict that a planet near 1.5 astronomical units (AU) should roughly be the same mass as Earth. Recently, a new model called Viscously Stirred Pebble Accretion (VSPA) has been developed that can explain the formation of the gas giants. This model envisions that the cores of the giant planets formed from 100- to 1,000-km bodies that directly accreted a population of pebbles—submeter-sized objects that slowly grew in the protoplanetary disk. Here we apply this model to the terrestrial planet region and find that it can reproduce the basic structure of the inner solar system, including a small Mars and a low-mass asteroid belt. Our models show that for an initial population of planetesimals with sizes similar to those of the main belt asteroids, VSPA becomes inefficient beyond ∼ 1.5 AU. As a result, Mars’s growth is stunted, and nothing large in the asteroid belt can accumulate. PMID:26512109

Growing the terrestrial planets from the gradual accumulation of submeter-sized objects.

PubMed

Levison, Harold F; Kretke, Katherine A; Walsh, Kevin J; Bottke, William F

2015-11-17

Building the terrestrial planets has been a challenge for planet formation models. In particular, classical theories have been unable to reproduce the small mass of Mars and instead predict that a planet near 1.5 astronomical units (AU) should roughly be the same mass as Earth. Recently, a new model called Viscously Stirred Pebble Accretion (VSPA) has been developed that can explain the formation of the gas giants. This model envisions that the cores of the giant planets formed from 100- to 1,000-km bodies that directly accreted a population of pebbles-submeter-sized objects that slowly grew in the protoplanetary disk. Here we apply this model to the terrestrial planet region and find that it can reproduce the basic structure of the inner solar system, including a small Mars and a low-mass asteroid belt. Our models show that for an initial population of planetesimals with sizes similar to those of the main belt asteroids, VSPA becomes inefficient beyond ∼ 1.5 AU. As a result, Mars's growth is stunted, and nothing large in the asteroid belt can accumulate.

Planar-Structure Perovskite Solar Cells with Efficiency beyond 21.

PubMed

Jiang, Qi; Chu, Zema; Wang, Pengyang; Yang, Xiaolei; Liu, Heng; Wang, Ye; Yin, Zhigang; Wu, Jinliang; Zhang, Xingwang; You, Jingbi

2017-12-01

Low temperature solution processed planar-structure perovskite solar cells gain great attention recently, while their power conversions are still lower than that of high temperature mesoporous counterpart. Previous reports are mainly focused on perovskite morphology control and interface engineering to improve performance. Here, this study systematically investigates the effect of precise stoichiometry, especially the PbI 2 contents on device performance including efficiency, hysteresis and stability. This study finds that a moderate residual of PbI 2 can deliver stable and high efficiency of solar cells without hysteresis, while too much residual PbI 2 will lead to serious hysteresis and poor transit stability. Solar cells with the efficiencies of 21.6% in small size (0.0737 cm 2 ) and 20.1% in large size (1 cm 2 ) with moderate residual PbI 2 in perovskite layer are obtained. The certificated efficiency for small size shows the efficiency of 20.9%, which is the highest efficiency ever recorded in planar-structure perovskite solar cells, showing the planar-structure perovskite solar cells are very promising. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.

PubMed

Kang, Dukjin; Oh, Sunok; Ahn, Sung-Min; Lee, Bong-Hee; Moon, Myeong Hee

2008-08-01

Exosomes, small membrane vesicles secreted by a multitude of cell types, are involved in a wide range of physiological roles such as intercellular communication, membrane exchange between cells, and degradation as an alternative to lysosomes. Because of the small size of exosomes (30-100 nm) and the limitations of common separation procedures including ultracentrifugation and flow cytometry, size-based fractionation of exosomes has been challenging. In this study, we used flow field-flow fractionation (FlFFF) to fractionate exosomes according to differences in hydrodynamic diameter. The exosome fractions collected from FlFFF runs were examined by transmission electron microscopy (TEM) to morphologically confirm their identification as exosomes. Exosomal lysates of each fraction were digested and analyzed using nanoflow LC-ESI-MS-MS for protein identification. FIFFF, coupled with mass spectrometry, allows nanoscale size-based fractionation of exosomes and is more applicable to primary cells and stem cells since it requires much less starting material than conventional gel-based separation, in-gel digestion and the MS-MS method.

Colour dependence of zodiacal light models

NASA Technical Reports Server (NTRS)

Giese, R. H.; Hanner, M. S.; Leinert, C.

1973-01-01

Colour models of the zodiacal light in the ecliptic have been calculated for both dielectric and metallic particles in the sub-micron and micron size range. Two colour ratios were computed, a blue ratio and a red ratio. The models with a size distribution proportional to s to the -2.5 power ds (where s is the particle radius) generally show a colour close to the solar colour and almost independent of elongation. Especially in the blue colour ratio there is generally no significant dependence on the lower cutoff size (0.1-1 micron). The main feature of absorbing particles is a reddening at small elongations. The models for size distributions proportional to s to the -4 power ds show larger departures from solar colour and more variation with model parameters. Colour measurements, including red and near infra-red, therefore are useful to distinguish between flat and steep size spectra and to verify the presence of slightly absorbing particles.

Management of gastric and duodenal neuroendocrine tumors

PubMed Central

Sato, Yuichi; Hashimoto, Satoru; Mizuno, Ken-ichi; Takeuchi, Manabu; Terai, Shuji

2016-01-01

Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis. Type II G-NETs (5%-6%) are associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome (MEN1-ZES). Both type I and II G-NETs are related to hypergastrinemia, are small in size, occur in multiple numbers, and are generally benign. In contrast, type III G-NETs (10%-15%) are not associated with hypergastrinemia, are large-sized single tumors, and are usually malignant. Therefore, surgical resection and chemotherapy are generally necessary for type III G-NETs, while endoscopic resection and follow-up, which are acceptable for the treatment of most type I and II G-NETs, are only acceptable for small and well differentiated type III G-NETs. D-NETs include gastrinomas (50%-60%), somatostatin-producing tumors (15%), nonfunctional serotonin-containing tumors (20%), poorly differentiated neuroendocrine carcinomas (< 3%), and gangliocytic paragangliomas (< 2%). Most D-NETs are located in the first or second part of the duodenum, with 20% occurring in the periampullary region. Therapy for D-NETs is based on tumor size, location, histological grade, stage, and tumor type. While endoscopic resection may be considered for small nonfunctional D-NETs (G1) located in the higher papilla region, surgical resection is necessary for most other D-NETs. However, there is no consensus regarding the ideal treatment of D-NETs. PMID:27570419

Designing Agricultural Development Projects for the Small Scale Farmers: Some Lessons from the World Bank Assistance Small Holder Oil Palm Development Scheme in Nigeria

NASA Astrophysics Data System (ADS)

Orewa, S. I.

The study was carried out to investigate farmers reasons for intercropping their oil palm farms with food and other cash crops rather than the sole oil palm planting arrangement specified for participation in the World Bank Assistance Smallholder Oil Palm development project financed during the 1975-83 period. The study was conducted at the Ekuku-Agbor Tree Crop Unit Zone (to the East) and Mosogar Tree Crop Unit Zone (to the Southwest) of the old Bendel State of Nigeria. A total of 35 oil palm farmers were randomly selected from each zone for the study. The study tried to identify the size of oil palm cultivated, types of food and cash crops planted and the proportion consumed and sold and the sufficiency of labour for various farm activities. The study showed that the average oil palm farm size at Ekuku-Agbor zone was smaller (about 1.57 ha) and more fragmented while for Mosogar zone it was 2.28 ha. However a greater percentage (over 65%) of the farms at both locations were within 0.01-2.00 ha farm size range which could be said to be relatively small. The study revealed that among other factors the farmers desire to ensure adequate family food needs which equates to food security and some cash to meet regular family financial needs necessitated their intercropping of the oil palm farms. Others include the need to maximize the returns from the use of labour which they considered a major limiting factor in farm maintenance and to take advantage of the relative high unit price of cassava and its products that prevailed then by cultivating on any available land space including the palm plantations and thereby increasing their farm income.

Different MR features for differentiation of intrahepatic mass-forming cholangiocarcinoma from hepatocellular carcinoma according to tumor size.

PubMed

Ni, Ting; Shang, Xiao-Sha; Wang, Wen-Tao; Hu, Xin-Xing; Zeng, Meng-Su; Rao, Sheng-Xiang

2018-06-05

To identify reliable magnetic resonance (MR) features for distinguishing mass-forming type of intrahepatic cholangiocarcinoma (IMCC) from hepatocellular carcinoma (HCC) based on tumor size. This retrospective study included 395 patients with pathologically confirmed IMCCs (n = 180) and HCCs (n = 215) who underwent pre-operative contrast-enhanced MRI including diffusion-weighted imaging (DWI). MR features were evaluated and clinical data were also recorded. All the characteristics were compared in small (≤3 cm) and large tumor (>3 cm) groups by univariate analysis and subsequently calculated by multivariable logistic regression analysis. Multivariable analysis revealed that rim arterial phase hyperenhancement [odds ratios (ORs) = 13.16], biliary dilation (OR = 23.42) and CA19-9 (OR = 21.45) were significant predictors of large IMCCs (n = 138), and washout appearance (OR = 0.036), enhancing capsule appearance (OR = 0.039), fat in mass (OR = 0.057), chronic liver disease (OR = 0.088) and alpha fetoprotein (OR = 0.019) were more frequently found in large HCCs (n = 143). For small IMCCs (n = 42) and HCCs (n = 72), rim arterial phase hyperenhancement (OR = 9.68), target appearance at DWI (OR = 12.51), alpha fetoprotein (OR = 0.12) and sex (OR = 0.20) were independent predictors in multivariate analysis. Valuable MR features and clinical factors varied for differential diagnosis of IMCCs and HCCs according to tumor size. Advances in knowledge: MR features for differential diagnosis of large IMCC and HCC (>3 cm) are in keeping with that recommended by LI-RADS. However, for small IMCCs and HCCs (≤3 cm), only rim enhancement on arterial phase and target appearance at DWI are reliable predictors.

Ultra Small Aperture Terminal: System Design and Test Results

NASA Technical Reports Server (NTRS)

Sohn, Philip Y.; Reinhart, Richard C.

1996-01-01

The Ultra Small Aperture Terminal (USAT) has been developed to test and demonstrate remote and broadcast satcom applications via the Advanced Communications Technology Satellite (ACTS). The design of these ground stations emphasize small size, low power consumption, portable and rugged terminals. Each ground station includes several custom design parts such as 35 cm diameter antenna, 1/4 Watt transmitter with built-in upconverter, and 4.0 dB Noise Figure (NF) receiver with built-in downconverter. In addition, state-of-the-art commercial parts such as highly stable ovenized crystal oscillators and dielectric resonator oscillators are used in the ground station design. Presented in this paper are system level design description, performance, and sample applications.

Trojan Binaries

NASA Astrophysics Data System (ADS)

Noll, K. S.

2017-12-01

The Jupiter Trojans, in the context of giant planet migration models, can be thought of as an extension of the small body populations found beyond Neptune in the Kuiper Belt. Binaries are a distinctive feature of small body populations in the Kuiper Belt with an especially high fraction apparent among the brightest Cold Classicals. The binary fraction, relative sizes, and separations in the dynamically excited populations (Scattered, Resonant) reflects processes that may have eroded a more abundant initial population. This trend continues in the Centaurs and Trojans where few binaries have been found. We review new evidence including a third resolved Trojan binary and lightcurve studies to understand how the Trojans are related to the small body populations that originated in the outer protoplanetary disk.

Population Variation Reveals Independent Selection toward Small Body Size in Chinese Debao Pony

PubMed Central

Kader, Adiljan; Li, Yan; Dong, Kunzhe; Irwin, David M.; Zhao, Qianjun; He, Xiaohong; Liu, Jianfeng; Pu, Yabin; Gorkhali, Neena Amatya; Liu, Xuexue; Jiang, Lin; Li, Xiangchen; Guan, Weijun; Zhang, Yaping; Wu, Dong-Dong; Ma, Yuehui

2016-01-01

Body size, one of the most important quantitative traits under evolutionary scrutiny, varies considerably among species and among populations within species. Revealing the genetic basis underlying this variation is very important, particularly in humans where there is a close relationship with diseases and in domestic animals as the selective patterns are associated with improvements in production traits. The Debao pony is a horse breed with small body size that is unique to China; however, it is unknown whether the size-related candidate genes identified in Western breeds also account for the small body size of the Debao pony. Here, we compared individual horses from the Debao population with other two Chinese horse populations using single nucleotide polymorphisms (SNPs) identified with the Equine SNP 65 Bead Chip. The previously reported size-related candidate gene HMGA2 showed a significant signature for selection, consistent with its role observed in human populations. More interestingly, we found a candidate gene TBX3, which had not been observed in previous studies on horse body size that displayed the highest differentiation and most significant association, and thus likely is the dominating factor for the small stature of the Debao pony. Further comparison between the Debao pony and other breeds of horses from around the world demonstrated that TBX3 was selected independently in the Debao pony, suggesting that there were multiple origins of small stature in the horse. PMID:26637467

Male group size, female distribution and changes in sexual segregation by Roosevelt elk

PubMed Central

Peterson, Leah M.

2017-01-01

Sexual segregation, or the differential use of space by males and females, is hypothesized to be a function of body size dimorphism. Sexual segregation can also manifest at small (social segregation) and large (habitat segregation) spatial scales for a variety of reasons. Furthermore, the connection between small- and large-scale sexual segregation has rarely been addressed. We studied a population of Roosevelt elk (Cervus elaphus roosevelti) across 21 years in north coastal California, USA, to assess small- and large-scale sexual segregation in winter. We hypothesized that male group size would associate with small-scale segregation and that a change in female distribution would associate with large-scale segregation. Variation in forage biomass might also be coupled to small and large-scale sexual segregation. Our findings were consistent with male group size associating with small-scale segregation and a change in female distribution associating with large-scale segregation. Females appeared to avoid large groups comprised of socially dominant males. Males appeared to occupy a habitat vacated by females because of a wider forage niche, greater tolerance to lethal risks, and, perhaps, to reduce encounters with other elk. Sexual segregation at both spatial scales was a poor predictor of forage biomass. Size dimorphism was coupled to change in sexual segregation at small and large spatial scales. Small scale segregation can seemingly manifest when all forage habitat is occupied by females and large scale segregation might happen when some forage habitat is not occupied by females. PMID:29121076

A survey of publication practices of single-case design researchers when treatments have small or large effects.

PubMed

Shadish, William R; Zelinsky, Nicole A M; Vevea, Jack L; Kratochwill, Thomas R

2016-09-01

The published literature often underrepresents studies that do not find evidence for a treatment effect; this is often called publication bias. Literature reviews that fail to include such studies may overestimate the size of an effect. Only a few studies have examined publication bias in single-case design (SCD) research, but those studies suggest that publication bias may occur. This study surveyed SCD researchers about publication preferences in response to simulated SCD results that show a range of small to large effects. Results suggest that SCD researchers are more likely to submit manuscripts that show large effects for publication and are more likely to recommend acceptance of manuscripts that show large effects when they act as a reviewer. A nontrivial minority of SCD researchers (4% to 15%) would drop 1 or 2 cases from the study if the effect size is small and then submit for publication. This article ends with a discussion of implications for publication practices in SCD research. © 2016 Society for the Experimental Analysis of Behavior.

First Earth-based Detection of a Superbolide on Jupiter

NASA Astrophysics Data System (ADS)

Hueso, Ricardo; Wesley, A.; Go, C.; Perez-Hoyos, S.; Wong, M. H.; Fletcher, L. N.; Sanchez-Lavega, A.; Boslough, M. B. E.; de Pater, I.; Orton, G. S.; Simon-Miller, A. A.; Djorgovski, S. G.; Edwards, M. L.; Hammel, H. B.; Clarke, J. T.; Noll, K. S.; Yanamandra-Fisher, P. A.

2010-10-01

On June 3, 2010 a bolide in Jupiter's atmosphere was observed from the Earth for the first time. The flash was detected by amateur astronomers A. Wesley and C. Go observing in two wavelength ranges. We present an analysis of the light curve of those observations that allow estimating the size of the object to be significantly smaller than the SL9 and the July 2009 Jupiter impact. Observations obtained a few days later by large telescopes including HST, VLT, Keck and Gemini showed no signature of the impact in Jupiter atmosphere confirming the small size of the impact body. A nearly continuous observation campaign based on several small telescopes by amateurs astronomers might allow an empirical determination of the flux of meteoroids in Jupiter with implications for the populations of small bodies in the outer solar system and may allow a better quantification of the threat of impacting bodies to Earth. Acknowledgements: RH, ASL and SPH are supported by the Spanish MICIIN AYA2009-10701 with FEDER and Grupos Gobierno Vasco IT-464-07. LNF is supported by a Glasstone Science Fellowship at the University of Oxford.

Community size as a factor in health partnerships in community parks and recreation, 2007.

PubMed

Payne, Laura L; Zimmermann, Jo An M; Mowen, Andrew J; Orsega-Smith, Elizabeth; Godbey, Geoffrey C

2013-07-25

Although partnerships between park and recreation agencies and health agencies are prevalent, little research has examined partnership characteristics and effectiveness among communities of different sizes. The objective of this study was to determine whether park and recreation leaders' perceptions of partnership characteristics, effectiveness, and outcomes vary by community size. A web-based survey was completed in 2007 by 1,217 National Recreation and Park Association members. Community size was divided into 4 categories: very small, small, medium, and large. Questions measured agencies' recognition of the need for partnerships, their level of experience, and the effectiveness and outcomes of partnerships. Larger communities were significantly more likely to recognize the need for and have more experience with partnerships than smaller communities. Very small and large communities partnered significantly more often with senior services, nonprofit health promotion agencies, and public health agencies than did small and medium ones. Large and small communities were significantly more likely than very small and medium communities to agree that their decision making in partnerships is inclusive and that they have clearly defined goals and objectives. Large communities were significantly more likely than very small communities to report that their partnership helped leverage resources, make policy changes, meet their mission statement, and link to funding opportunities. Community size shapes partnership practices, effectiveness, and outcomes. Very small communities are disadvantaged in developing and managing health partnerships. Increasing education, training, and funding opportunities for small and rural park and recreation agencies may enable them to more effectively partner with organizations to address community health concerns.

Community Size as a Factor in Health Partnerships in Community Parks and Recreation, 2007

PubMed Central

Zimmermann, Jo An M.; Mowen, Andrew J.; Orsega-Smith, Elizabeth; Godbey, Geoffrey C.

2013-01-01

Introduction Although partnerships between park and recreation agencies and health agencies are prevalent, little research has examined partnership characteristics and effectiveness among communities of different sizes. The objective of this study was to determine whether park and recreation leaders’ perceptions of partnership characteristics, effectiveness, and outcomes vary by community size. Methods A web-based survey was completed in 2007 by 1,217 National Recreation and Park Association members. Community size was divided into 4 categories: very small, small, medium, and large. Questions measured agencies’ recognition of the need for partnerships, their level of experience, and the effectiveness and outcomes of partnerships. Results Larger communities were significantly more likely to recognize the need for and have more experience with partnerships than smaller communities. Very small and large communities partnered significantly more often with senior services, nonprofit health promotion agencies, and public health agencies than did small and medium ones. Large and small communities were significantly more likely than very small and medium communities to agree that their decision making in partnerships is inclusive and that they have clearly defined goals and objectives. Large communities were significantly more likely than very small communities to report that their partnership helped leverage resources, make policy changes, meet their mission statement, and link to funding opportunities. Conclusion Community size shapes partnership practices, effectiveness, and outcomes. Very small communities are disadvantaged in developing and managing health partnerships. Increasing education, training, and funding opportunities for small and rural park and recreation agencies may enable them to more effectively partner with organizations to address community health concerns. PMID:23886043

Pituitary Tumors

MedlinePlus

... Organizations Publications Definition The pituitary is a small, bean-sized gland that is below the hypothalamus, a ... common diseases. × Definition The pituitary is a small, bean-sized gland that is below the hypothalamus, a ...

A quantitative study of ramped radio frequency, magnetization transfer, and slab thickness in three-dimensional time-of-flight magnetic resonance angiography in a patient population.

PubMed

Goodrich, K C; Blatter, D D; Parker, D L; Du, Y P; Meyer, K J; Bernstein, M A

1996-06-01

The authors compare the effectiveness of various magnetic resonance (MR) angiography acquisition strategies in enhancing the visibility of small intracranial vessels. Blood vessel contrast-to-noise ratio (CNR) in time-of-flight MR angiography was studied as a function of vessel size and several selectable imaging parameters. Contrast-to-noise measurements were made on 257 vessel segments ranging in size from 0.3 mm to 4.2 mm in patients who recently had undergone intraarterial cerebral angiography. Imaging parameters studied included magnetization transfer, spatially variable radio frequency (RF) pulse profile (ramped RF), and imaging slab thickness. The combination of thin slabs (16 slices/slab), ramped RF, and magnetization transfer resulted in the highest CNR for all but the smallest vessel sizes. The smallest vessels (< 0.5 mm) had the highest CNR, using the thick slab (64 slices/slab) with ramped RF and magnetization transfer. Magnetization transfer always improved vessel CNR, but the improvement diminished as the slab thickness was reduced. The CNR increased with a decrease in slab thickness for all but the smallest vessel sizes. Overall, the results provide a quantitative demonstration that inflow enhancement of blood is reduced for small vessels. Thus, whereas magnetization transfer is important at all vessel sizes, it becomes the primary factor in improving the visibility of the smallest vessels.

Genome size diversity in orchids: consequences and evolution

PubMed Central

Leitch, I. J.; Kahandawala, I.; Suda, J.; Hanson, L.; Ingrouille, M. J.; Chase, M. W.; Fay, M. F.

2009-01-01

Background The amount of DNA comprising the genome of an organism (its genome size) varies a remarkable 40 000-fold across eukaryotes, yet most groups are characterized by much narrower ranges (e.g. 14-fold in gymnosperms, 3- to 4-fold in mammals). Angiosperms stand out as one of the most variable groups with genome sizes varying nearly 2000-fold. Nevertheless within angiosperms the majority of families are characterized by genomes which are small and vary little. Species with large genomes are mostly restricted to a few monocots families including Orchidaceae. Scope A survey of the literature revealed that genome size data for Orchidaceae are comparatively rare representing just 327 species. Nevertheless they reveal that Orchidaceae are currently the most variable angiosperm family with genome sizes ranging 168-fold (1C = 0·33–55·4 pg). Analysing the data provided insights into the distribution, evolution and possible consequences to the plant of this genome size diversity. Conclusions Superimposing the data onto the increasingly robust phylogenetic tree of Orchidaceae revealed how different subfamilies were characterized by distinct genome size profiles. Epidendroideae possessed the greatest range of genome sizes, although the majority of species had small genomes. In contrast, the largest genomes were found in subfamilies Cypripedioideae and Vanilloideae. Genome size evolution within this subfamily was analysed as this is the only one with reasonable representation of data. This approach highlighted striking differences in genome size and karyotype evolution between the closely related Cypripedium, Paphiopedilum and Phragmipedium. As to the consequences of genome size diversity, various studies revealed that this has both practical (e.g. application of genetic fingerprinting techniques) and biological consequences (e.g. affecting where and when an orchid may grow) and emphasizes the importance of obtaining further genome size data given the considerable phylogenetic gaps which have been highlighted by the current study. PMID:19168860

Preparing the Production of a New Product in Small and Medium-Sized Enterprises by Using the Method of Projects Management

NASA Astrophysics Data System (ADS)

Bijańska, Jolanta; Wodarski, Krzysztof; Wójcik, Janusz

2016-06-01

Efficient and effective preparation the production of new products is important requirement for a functioning and development of small and medium-sized enterprises. One of the methods, which support the fulfilment of this condition is project management. This publication presents the results of considerations, which are aimed at developing a project management model of preparation the production of a new product, adopted to specificity of small and medium-sized enterprises.

The development of internet based ship design support system for small and medium sized shipyards

NASA Astrophysics Data System (ADS)

Shin, Sung-Chul; Lee, Soon-Sup; Kang, Dong-Hoon; Lee, Kyung-Ho

2012-03-01

In this paper, a prototype of ship basic planning system is implemented for the small and medium sized shipyards based on the internet technology and concurrent engineering concept. The system is designed from the user requirements. Consequently, standardized development environment and tools are selected. These tools are used for the system development to define and evaluate core application technologies. The system will contribute to increasing competitiveness of small and medium sized shipyards in the 21st century industrial en-vironment.

Physical activity text messaging interventions in adults: a systematic review.

PubMed

Buchholz, Susan Weber; Wilbur, JoEllen; Ingram, Diana; Fogg, Louis

2013-08-01

Physical inactivity is a leading health risk factor for mortality worldwide. Researchers are examining innovative techniques including the use of mobile technology to promote physical activity. One such technology, text messaging, is emerging internationally as a method to communicate with and motivate individuals to engage in healthy behaviors, including physical activity. Review the existing scientific literature on adult physical activity text messaging interventions. This systematic review examined research papers that addressed physical activity text messaging intervention studies in adults. Using multiple databases, the search strategy included published English language studies through October 1, 2011. An author-developed data collection tool was used independently by two reviewers to extract and examine the selected study variables. The initial search resulted in the identification of 200 publications. Eleven publications representing 10 studies were included in the final review. Studies were conducted in seven countries with over half the studies being randomized controlled trials. Participants of the studies were predominantly young to middle aged women. Physical activity data were mainly obtained by self-report although three studies used pedometers or accelerometers. Interventions ranged from only sending out text messages to combining text messages with educational materials, staff support, and/or Internet technology. Minimal information was given regarding development or number of text messages used. The median effect size for the studies was 0.50. To date, using text messaging as a method to promote physical activity has only been studied by a small group of researchers. Current physical activity text messaging literature is characterized by small sample sizes, heterogeneous but positive effect sizes, and a lack of specificity as to the development of the text messages used in these studies. Further research in this area is imperative to facilitate the expansion of mobile technology to promote physical activity. © 2013 Sigma Theta Tau International.

MRI Features of Hepatocellular Carcinoma Related to Biologic Behavior

PubMed Central

Cho, Eun-Suk

2015-01-01

Imaging studies including magnetic resonance imaging (MRI) play a crucial role in the diagnosis and staging of hepatocellular carcinoma (HCC). Several recent studies reveal a large number of MRI features related to the prognosis of HCC. In this review, we discuss various MRI features of HCC and their implications for the diagnosis and prognosis as imaging biomarkers. As a whole, the favorable MRI findings of HCC are small size, encapsulation, intralesional fat, high apparent diffusion coefficient (ADC) value, and smooth margins or hyperintensity on the hepatobiliary phase of gadoxetic acid-enhanced MRI. Unfavorable findings include large size, multifocality, low ADC value, non-smooth margins or hypointensity on hepatobiliary phase images. MRI findings are potential imaging biomarkers in patients with HCC. PMID:25995679

Factors affecting computer mouse use for young children: implications for AAC.

PubMed

Costigan, F Aileen; Light, Janice C; Newell, Karl M

2012-06-01

More than 12% of preschoolers receiving special education services have complex communication needs, including increasing numbers of children who do not have significant motor impairments (e.g., children with autism spectrum disorders, Down syndrome, etc.). In order to meet their diverse communication needs (e.g., face-to-face, written, Internet, telecommunication), these children may use mainstream technologies accessed via the mouse, yet little is known about factors that affect the mouse performance of young children. This study used a mixed factorial design to investigate the effects of age, target size, and angle of approach on accuracy and time required for accurate target selection with a mouse for 20 3-year-old and 20 4-year-old children. The 4-year-olds were generally more accurate and faster than the 3-year-olds. Target size and angle mediated differences in performance within age groups. The 3-year-olds were more accurate and faster in selecting the medium and large targets relative to the small target, were faster in selecting the large relative to the medium target, and were faster in selecting targets along the vertical relative to the diagonal angle. The 4-year-olds were faster in selecting the medium and large targets relative to the small target. Implications for improving access to AAC include the preliminary suggestion of age-related threshold target sizes that support sufficient accuracy, the possibility of efficiency benefits when target size is increased up to an age-related threshold, and identification of the potential utility of the vertical angle as a context for training navigational input device use.

Bank Size and Small- and Medium-sized Enterprise (SME) Lending: Evidence from China

PubMed Central

SHEN, YAN; SHEN, MINGGAO; XU, ZHONG; BAI, YING

2014-01-01

Summary Using panel data collected in 2005, we evaluate how bank size, discretion over credit, incentive schemes, competition, and the institutional environment affect lending to small- and medium-sized enterprises in China. We deal with the endogeneity problem using instrumental variables, and a reduced-form approach is also applied to allow for weak instruments in estimation. We find that total bank asset is an insignificant factor for banks’ decision on small- and medium-enterprise (SME) lending, but more local lending authority, more competition, carefully designed incentive schemes, and stronger law enforcement encourage commercial banks to lend to SMEs. PMID:26052179

THE OCCURRENCE RATE OF SMALL PLANETS AROUND SMALL STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dressing, Courtney D.; Charbonneau, David, E-mail: cdressing@cfa.harvard.edu

We use the optical and near-infrared photometry from the Kepler Input Catalog to provide improved estimates of the stellar characteristics of the smallest stars in the Kepler target list. We find 3897 dwarfs with temperatures below 4000 K, including 64 planet candidate host stars orbited by 95 transiting planet candidates. We refit the transit events in the Kepler light curves for these planet candidates and combine the revised planet/star radius ratios with our improved stellar radii to revise the radii of the planet candidates orbiting the cool target stars. We then compare the number of observed planet candidates to themore » number of stars around which such planets could have been detected in order to estimate the planet occurrence rate around cool stars. We find that the occurrence rate of 0.5-4 R{sub Circled-Plus} planets with orbital periods shorter than 50 days is 0.90{sup +0.04}{sub -0.03} planets per star. The occurrence rate of Earth-size (0.5-1.4 R{sub Circled-Plus }) planets is constant across the temperature range of our sample at 0.51{sub -0.05}{sup +0.06} Earth-size planets per star, but the occurrence of 1.4-4 R{sub Circled-Plus} planets decreases significantly at cooler temperatures. Our sample includes two Earth-size planet candidates in the habitable zone, allowing us to estimate that the mean number of Earth-size planets in the habitable zone is 0.15{sup +0.13}{sub -0.06} planets per cool star. Our 95% confidence lower limit on the occurrence rate of Earth-size planets in the habitable zones of cool stars is 0.04 planets per star. With 95% confidence, the nearest transiting Earth-size planet in the habitable zone of a cool star is within 21 pc. Moreover, the nearest non-transiting planet in the habitable zone is within 5 pc with 95% confidence.« less

Selecting Sustainability Indicators for Small to Medium Sized Urban Water Systems Using Fuzzy-ELECTRE.

PubMed

Chhipi-Shrestha, Gyan; Hewage, Kasun; Sadiq, Rehan

2017-03-01

  Urban water systems (UWSs) are challenged by the sustainability perspective. Certain limitations of the sustainability of centralized UWSs and decentralized household level wastewater treatments can be overcome by managing UWSs at an intermediate scale, referred to as small to medium sized UWSs (SMUWSs). SMUWSs are different from large UWSs, mainly in terms of smaller infrastructure, data limitation, smaller service area, and institutional limitations. Moreover, sustainability assessment systems to evaluate the sustainability of an entire UWS are very limited and confined only to large UWSs. This research addressed the gap and has developed a set of 38 applied sustainability performance indicators (SPIs) by using fuzzy-Elimination and Choice Translating Reality (ELECTRE) I outranking method to assess the sustainability of SMUWSs. The developed set of SPIs can be applied to existing and new SMUWSs and also provides a flexibility to include additional SPIs in the future based on the same selection criteria.

About Nano-JASMINE Satellite System and Project Status

NASA Astrophysics Data System (ADS)

Sako, Nobutada

Intelligent Space Systems Laboratory, The University of Tokyo (ISSL) and National Astronomical Observatory of Japan (NAO) have been developing a small infrared astrometry satellite named “Nano-JASMINE”. The satellite size is about 50cm cubic and 20kg, which plays a pre-cursor role of JASMINE Project which is programmed by NAO and JAXA. In addition, since there has been only one astrometry satellite HIPPARCOS by ESA in the past, Nano-JASMINE is also expected to achieve certain scientific results in the field of astrometry. In this project, ISSL aims to develop new advanced small satellite bus system whose performance is comparable to that of 100-500kg sized satellites, including attitude stability of 1 arc-second and thermal stability of the mission subsystem of 1 mK. This paper overviews the Nano-JASMINE bus system with emphasis on attitude and thermal control systems.

Unpinning of spiral waves from rectangular obstacles by stimulated wave trains

NASA Astrophysics Data System (ADS)

Ponboonjaroenchai, Benjamas; Srithamma, Panatda; Kumchaiseemak, Nakorn; Sutthiopad, Malee; Müller, Stefan C.; Luengviriya, Chaiya; Luengviriya, Jiraporn

2017-09-01

Pinned spiral waves are exhibited in many excitable media. In cardiology, lengthened tachycardia correspond to propagating action potential in forms of spiral waves pinned to anatomical obstacles including veins and scares. Thus, elimination such waves is important particularly in medical treatments. We present study of unpinning of a spiral wave by a wave train initiated by periodic stimuli at a given location. The spiral wave is forced to leave the rectangular obstacle when the period of the wave train is shorter than a threshold Tunpin. For small obstacles, Tunpin decreases when the obstacle size is increased. Furthermore, Tunpin depends on the obstacle orientation with respect to the wave train propagation. For large obstacles, Tunpin is independent to the obstacle size. It implies that the orientation of the obstacle plays an important role in the unpinning of the spiral wave, especially for small rectangular obstacles.

Onsite Calibration of a Precision IPRT Based on Gallium and Gallium-Based Small-Size Eutectic Points

NASA Astrophysics Data System (ADS)

Sun, Jianping; Hao, Xiaopeng; Zeng, Fanchao; Zhang, Lin; Fang, Xinyun

2017-04-01

Onsite thermometer calibration with temperature scale transfer technology based on fixed points can effectively improve the level of industrial temperature measurement and calibration. The present work performs an onsite calibration of a precision industrial platinum resistance thermometer near room temperature. The calibration is based on a series of small-size eutectic points, including Ga-In (15.7°C), Ga-Sn (20.5°C), Ga-Zn (25.2°C), and a Ga fixed point (29.7°C), developed in a portable multi-point automatic realization apparatus. The temperature plateaus of the Ga-In, Ga-Sn, and Ga-Zn eutectic points and the Ga fixed point last for longer than 2 h, and their reproducibility was better than 5 mK. The device is suitable for calibrating non-detachable temperature sensors in advanced environmental laboratories and industrial fields.

The ISMARA client

PubMed Central

Ioannidis, Vassilios; van Nimwegen, Erik; Stockinger, Heinz

2016-01-01

ISMARA ( ismara.unibas.ch) automatically infers the key regulators and regulatory interactions from high-throughput gene expression or chromatin state data. However, given the large sizes of current next generation sequencing (NGS) datasets, data uploading times are a major bottleneck. Additionally, for proprietary data, users may be uncomfortable with uploading entire raw datasets to an external server. Both these problems could be alleviated by providing a means by which users could pre-process their raw data locally, transferring only a small summary file to the ISMARA server. We developed a stand-alone client application that pre-processes large input files (RNA-seq or ChIP-seq data) on the user's computer for performing ISMARA analysis in a completely automated manner, including uploading of small processed summary files to the ISMARA server. This reduces file sizes by up to a factor of 1000, and upload times from many hours to mere seconds. The client application is available from ismara.unibas.ch/ISMARA/client. PMID:28232860

Formation of low resistivity titanium silicide gates in semiconductor integrated circuits

DOEpatents

Ishida, Emi [Sunnyvale, CA

1999-08-10

A method of forming a titanium silicide (69) includes the steps of forming a transistor having a source region (58), a drain region (60) and a gate structure (56) and forming a titanium layer (66) over the transistor. A first anneal is performed with a laser anneal at an energy level that causes the titanium layer (66) to react with the gate structure (56) to form a high resistivity titanium silicide phase (68) having substantially small grain sizes. The unreacted portions of the titanium layer (66) are removed and a second anneal is performed, thereby causing the high resistivity titanium silicide phase (68) to convert to a low resistivity titanium silicide phase (69). The small grain sizes obtained by the first anneal allow low resistivity titanium silicide phase (69) to be achieved at device geometries less than about 0.25 micron.

Sustainability and Small to Medium Sized Enterprises--How to Engage Them

ERIC Educational Resources Information Center

Condon, Linda

2004-01-01

Small and medium sized enterprises (SMEs) have a major advantage over larger organisations in regard to addressing sustainability issues--their size means they are able to react very quickly to changes in the business environment. They are disadvantaged, however, by lack of information on marketplace changes that make sustainability an opportunity…

77 FR 58747 - Small Business Size Standards: Real Estate and Rental and Leasing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... anchor size standards is appropriate in the current economy; whether there are gaps in SBA's methodology... independent agent), employee based costs (such as wages and payroll taxes), and material costs. For SBA's size... Estate and Rental and Leasing AGENCY: U.S. Small Business Administration. ACTION: Final rule. SUMMARY...