User Requirements Analysis For Digital Library Application Using Quality Function Deployment.

NASA Astrophysics Data System (ADS)

Wulandari, Lily; Sularto, Lana; Yusnitasari, Tristyanti; Ikasari, Diana

2017-03-01

This study attemp to build Smart Digital Library to be used by the wider community wherever they are. The system is built in the form of Smart Digital Library portal which uses semantic similarity method (Semantic Similarity) to search journals, articles or books by title or author name. This method is also used to determine the recommended books to be read by visitors of Smart Digital Library based on testimony from a previous reader automatically. Steps being taken in the development of Smart Digital Library system is the analysis phase, design phase, testing and implementation phase. At this stage of the analysis using WebQual for the preparation of the instruments to be distributed to the respondents and the data obtained from the respondents will be processed using Quality Function Deployment. In the analysis phase has the purpose of identifying consumer needs and technical requirements. The analysis was performed to a digital library on the web digital library Gunadarma University, Bogor Institute of Agriculture, University of Indonesia, etc. The questionnaire was distributed to 200 respondents. The research methodology begins with the collection of user requirements and analyse it using QFD. Application design is funded by the government through a program of Featured Universities Research by the Directorate General of Higher Education (DIKTI). Conclusions from this research are identified which include the Consumer Requirements of digital library application. The elements of the consumers requirements consists of 13 elements and 25 elements of Engineering Characteristics digital library requirements. Therefore the design of digital library applications that will be built, is designed according to the findings by eliminating features that are not needed by restaurant based on QFD House of Quality.

zipHMMlib: a highly optimised HMM library exploiting repetitions in the input to speed up the forward algorithm.

PubMed

Sand, Andreas; Kristiansen, Martin; Pedersen, Christian N S; Mailund, Thomas

2013-11-22

Hidden Markov models are widely used for genome analysis as they combine ease of modelling with efficient analysis algorithms. Calculating the likelihood of a model using the forward algorithm has worst case time complexity linear in the length of the sequence and quadratic in the number of states in the model. For genome analysis, however, the length runs to millions or billions of observations, and when maximising the likelihood hundreds of evaluations are often needed. A time efficient forward algorithm is therefore a key ingredient in an efficient hidden Markov model library. We have built a software library for efficiently computing the likelihood of a hidden Markov model. The library exploits commonly occurring substrings in the input to reuse computations in the forward algorithm. In a pre-processing step our library identifies common substrings and builds a structure over the computations in the forward algorithm which can be reused. This analysis can be saved between uses of the library and is independent of concrete hidden Markov models so one preprocessing can be used to run a number of different models.Using this library, we achieve up to 78 times shorter wall-clock time for realistic whole-genome analyses with a real and reasonably complex hidden Markov model. In one particular case the analysis was performed in less than 8 minutes compared to 9.6 hours for the previously fastest library. We have implemented the preprocessing procedure and forward algorithm as a C++ library, zipHMM, with Python bindings for use in scripts. The library is available at http://birc.au.dk/software/ziphmm/.

Little Red School House, New York City.

ERIC Educational Resources Information Center

Pearson, Clifford A.

2001-01-01

Discusses how architects successfully added a new 10,000 square-foot building, complete with glass-fronted library and skylit art room, to two existing structures built at different times and with different floor heights. Photos and a floorplan are included. (GR)

Whitmore Library: A New Concept of Public Library Services.

ERIC Educational Resources Information Center

Schuurman, Guy

Until 1972, library services in Salt Lake County consisted of a group of branch libraries with nearly identical collections for recreational reading. Because the needs of the community had become more complex, a new regional library was built to coordinate library operations and establish new services. Among the innovations in public library…

A Report on New Haven's Library Neighborhood Centers.

ERIC Educational Resources Information Center

Bloss, Meredith

A library neighborhood center is a community built around a branch library, providing the usual branch library functions of self-education and improvement. Four of New Haven's eight branch libraries are designed as library neighborhood centers. The centers are supported by the Ford Foundation, the City of New Haven, the Office of Economic…

Development of a large peptoid-DOTA combinatorial library.

PubMed

Singh, Jaspal; Lopes, Daniel; Gomika Udugamasooriya, D

2016-09-01

Conventional one-bead one-compound (OBOC) library synthesis is typically used to identify molecules with therapeutic value. The design and synthesis of OBOC libraries that contain molecules with imaging or even potentially therapeutic and diagnostic capacities (e.g. theranostic agents) has been overlooked. The development of a therapeutically active molecule with a built-in imaging component for a certain target is a daunting task, and structure-based rational design might not be the best approach. We hypothesize to develop a combinatorial library with potentially therapeutic and imaging components fused together in each molecule. Such molecules in the library can be used to screen, identify, and validate as direct theranostic candidates against targets of interest. As the first step in achieving that aim, we developed an on-bead library of 153,600 Peptoid-DOTA compounds in which the peptoids are the target-recognizing and potentially therapeutic components and the DOTA is the imaging component. We attached the DOTA scaffold to TentaGel beads using one of the four arms of DOTA, and we built a diversified 6-mer peptoid library on the remaining three arms. We evaluated both the synthesis and the mass spectrometric sequencing capacities of the test compounds and of the final library. The compounds displayed unique ionization patterns including direct breakages of the DOTA scaffold into two units, allowing clear decoding of the sequences. Our approach provides a facile synthesis method for the complete on-bead development of large peptidomimetic-DOTA libraries for screening against biological targets for the identification of potential theranostic agents in the future. © 2016 The Authors. Biopolymers Published by Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 673-684, 2016. © 2016 The Authors. Biopolymers Published by Wiley Periodicals, Inc.

Medical school libraries in the United States and Canada built between 1961 and 1971.

PubMed Central

Beatty, W K; Beatty, V L

1975-01-01

Twenty-four medical school libraries in the United States and Canada built between 1961 and 1971 were surveyed by means of questionnaires and visits. Results indicated that half of these libraries will have reached maximum functional capacity approximately six years after they moved into their new quarters. Space for technical processing is generally much less than required. Special features and examples of effective planning are described, and problems in arrangement, traffic patterns for people and materials, and the lack of logical expansion space are discussed. Comparisons are made with a similar survey of twenty medical school libraries made in 1961. Images PMID:1191825

Update on PISCES

NASA Technical Reports Server (NTRS)

Pearson, Don; Hamm, Dustin; Kubena, Brian; Weaver, Jonathan K.

2010-01-01

An updated version of the Platform Independent Software Components for the Exploration of Space (PISCES) software library is available. A previous version was reported in Library for Developing Spacecraft-Mission-Planning Software (MSC-22983), NASA Tech Briefs, Vol. 25, No. 7 (July 2001), page 52. To recapitulate: This software provides for Web-based, collaborative development of computer programs for planning trajectories and trajectory- related aspects of spacecraft-mission design. The library was built using state-of-the-art object-oriented concepts and software-development methodologies. The components of PISCES include Java-language application programs arranged in a hierarchy of classes that facilitates the reuse of the components. As its full name suggests, the PISCES library affords platform-independence: The Java language makes it possible to use the classes and application programs with a Java virtual machine, which is available in most Web-browser programs. Another advantage is expandability: Object orientation facilitates expansion of the library through creation of a new class. Improvements in the library since the previous version include development of orbital-maneuver- planning and rendezvous-launch-window application programs, enhancement of capabilities for propagation of orbits, and development of a desktop user interface.

Library of the Year 2008: Laramie County Library System, Wyoming--The Impact Library

ERIC Educational Resources Information Center

Berry, John N., III

2008-01-01

This article features Laramie County Library System (LCLS) of Cheyenne, Wyoming, which is named as Gale/"Library Journal" 2008 Library of the Year. It is not just strong, effective publicity or the fine new building or even a staff built around its ability to connect with the people, although all of those things add to the impact of…

School Libraries and Innovation

ERIC Educational Resources Information Center

McGrath, Kevin G.

2015-01-01

School library programs have measured success by improved test scores. But how do next-generation school libraries demonstrate success as they strive to be centers of innovation and creativity? These libraries offer solutions for school leaders who struggle to restructure existing systems built around traditional silos of learning (subjects and…

Mobile Timekeeping Application Built on Reverse-Engineered JPL Infrastructure

NASA Technical Reports Server (NTRS)

Witoff, Robert J.

2013-01-01

Every year, non-exempt employees cumulatively waste over one man-year tracking their time and using the timekeeping Web page to save those times. This app eliminates this waste. The innovation is a native iPhone app. Libraries were built around a reverse- engineered JPL API. It represents a punch-in/punch-out paradigm for timekeeping. It is accessible natively via iPhones, and features ease of access. Any non-exempt employee can natively punch in and out, as well as save and view their JPL timecard. This app is built on custom libraries created by reverse-engineering the standard timekeeping application. Communication is through custom libraries that re-route traffic through BrowserRAS (remote access service). This has value at any center where employees track their time.

Stimfit: quantifying electrophysiological data with Python

PubMed Central

Guzman, Segundo J.; Schlögl, Alois; Schmidt-Hieber, Christoph

2013-01-01

Intracellular electrophysiological recordings provide crucial insights into elementary neuronal signals such as action potentials and synaptic currents. Analyzing and interpreting these signals is essential for a quantitative understanding of neuronal information processing, and requires both fast data visualization and ready access to complex analysis routines. To achieve this goal, we have developed Stimfit, a free software package for cellular neurophysiology with a Python scripting interface and a built-in Python shell. The program supports most standard file formats for cellular neurophysiology and other biomedical signals through the Biosig library. To quantify and interpret the activity of single neurons and communication between neurons, the program includes algorithms to characterize the kinetics of presynaptic action potentials and postsynaptic currents, estimate latencies between pre- and postsynaptic events, and detect spontaneously occurring events. We validate and benchmark these algorithms, give estimation errors, and provide sample use cases, showing that Stimfit represents an efficient, accessible and extensible way to accurately analyze and interpret neuronal signals. PMID:24600389

PLANS; a finite element program for nonlinear analysis of structures. Volume 2: User's manual

NASA Technical Reports Server (NTRS)

Pifko, A.; Armen, H., Jr.; Levy, A.; Levine, H.

1977-01-01

The PLANS system, rather than being one comprehensive computer program, is a collection of finite element programs used for the nonlinear analysis of structures. This collection of programs evolved and is based on the organizational philosophy in which classes of analyses are treated individually based on the physical problem class to be analyzed. Each of the independent finite element computer programs of PLANS, with an associated element library, can be individually loaded and used to solve the problem class of interest. A number of programs have been developed for material nonlinear behavior alone and for combined geometric and material nonlinear behavior. The usage, capabilities, and element libraries of the current programs include: (1) plastic analysis of built-up structures where bending and membrane effects are significant, (2) three dimensional elastic-plastic analysis, (3) plastic analysis of bodies of revolution, and (4) material and geometric nonlinear analysis of built-up structures.

Worthington Libraries, OH

ERIC Educational Resources Information Center

Berry, John N., III

2007-01-01

Worthington, Ohio, has deep library roots. A library has been part of its history since the planning by settlers before the city's birth in 1803. Among the treasures brought by James Kilbourne and the Scioto Company from Connecticut to the new, planned community they built was a collection of books for their new subscription library. The books…

Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yaung, Stephanie J.; Deng, Luxue; Li, Ning

Elucidating functions of commensal microbial genes in the mammalian gut is challenging because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. We present Temporal FUnctional Metagenomics sequencing (TFUMseq), a platform to functionally mine bacterial genomes for genes that contribute to fitness of commensal bacteria in vivo. Our approach uses metagenomic DNA to construct large-scale heterologous expression libraries that are tracked over time in vivo by deep sequencing and computational methods. To demonstrate our approach, we built a TFUMseq plasmid library using the gut commensal Bacteroides thetaiotaomicron (Bt) and introduced Escherichia coli carrying this library into germfree mice. Populationmore » dynamics of library clones revealed Bt genes conferring significant fitness advantages in E. coli over time, including carbohydrate utilization genes, with a Bt galactokinase central to early colonization, and subsequent dominance by a Bt glycoside hydrolase enabling sucrose metabolism coupled with co-evolution of the plasmid library and E. coli genome driving increased galactose utilization. Here, our findings highlight the utility of functional metagenomics for engineering commensal bacteria with improved properties, including expanded colonization capabilities in vivo.« less

Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics

DOE PAGES

Yaung, Stephanie J.; Deng, Luxue; Li, Ning; ...

2015-03-11

Elucidating functions of commensal microbial genes in the mammalian gut is challenging because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. We present Temporal FUnctional Metagenomics sequencing (TFUMseq), a platform to functionally mine bacterial genomes for genes that contribute to fitness of commensal bacteria in vivo. Our approach uses metagenomic DNA to construct large-scale heterologous expression libraries that are tracked over time in vivo by deep sequencing and computational methods. To demonstrate our approach, we built a TFUMseq plasmid library using the gut commensal Bacteroides thetaiotaomicron (Bt) and introduced Escherichia coli carrying this library into germfree mice. Populationmore » dynamics of library clones revealed Bt genes conferring significant fitness advantages in E. coli over time, including carbohydrate utilization genes, with a Bt galactokinase central to early colonization, and subsequent dominance by a Bt glycoside hydrolase enabling sucrose metabolism coupled with co-evolution of the plasmid library and E. coli genome driving increased galactose utilization. Here, our findings highlight the utility of functional metagenomics for engineering commensal bacteria with improved properties, including expanded colonization capabilities in vivo.« less

New library buildings: the Health Sciences Library, Memorial University of Newfoundland, St. John's.

PubMed Central

Fredericksen, R B

1979-01-01

The new Health Sciences Library of Memorial University of Newfoundland is described and illustrated. A library facility that forms part of a larger health sciences center, this is a medium-sized academic health sciences library built on a single level. Along with a physical description of the library and its features, the concepts of single-level libraries, phased occupancy, and the project management approach to building a large health center library are discussed in detail. Images PMID:476319

Landlab: an Open-Source Python Library for Modeling Earth Surface Dynamics

NASA Astrophysics Data System (ADS)

Gasparini, N. M.; Adams, J. M.; Hobley, D. E. J.; Hutton, E.; Nudurupati, S. S.; Istanbulluoglu, E.; Tucker, G. E.

2016-12-01

Landlab is an open-source Python modeling library that enables users to easily build unique models to explore earth surface dynamics. The Landlab library provides a number of tools and functionalities that are common to many earth surface models, thus eliminating the need for a user to recode fundamental model elements each time she explores a new problem. For example, Landlab provides a gridding engine so that a user can build a uniform or nonuniform grid in one line of code. The library has tools for setting boundary conditions, adding data to a grid, and performing basic operations on the data, such as calculating gradients and curvature. The library also includes a number of process components, which are numerical implementations of physical processes. To create a model, a user creates a grid and couples together process components that act on grid variables. The current library has components for modeling a diverse range of processes, from overland flow generation to bedrock river incision, from soil wetting and drying to vegetation growth, succession and death. The code is freely available for download (https://github.com/landlab/landlab) or can be installed as a Python package. Landlab models can also be built and run on Hydroshare (www.hydroshare.org), an online collaborative environment for sharing hydrologic data, models, and code. Tutorials illustrating a wide range of Landlab capabilities such as building a grid, setting boundary conditions, reading in data, plotting, using components and building models are also available (https://github.com/landlab/tutorials). The code is also comprehensively documented both online and natively in Python. In this presentation, we illustrate the diverse capabilities of Landlab. We highlight existing functionality by illustrating outcomes from a range of models built with Landlab - including applications that explore landscape evolution and ecohydrology. Finally, we describe the range of resources available for new users.

Peroxisome Mini-Libraries: Systematic Approaches to Study Peroxisomes Made Easy.

PubMed

Dahan, Noa; Schuldiner, Maya; Zalckvar, Einat

2017-01-01

High-throughput methodologies have been extensively used in the budding yeast, Saccharomyces cerevisiae, to uncover fundamental principles of cell biology. Over the years, several collections of yeast strains (libraries) were built to enable systematic exploration of cellular functions. However, using these libraries experimentally is often labor intensive and restricted to laboratories that hold high throughput platforms. Utilizing the available full genome libraries we handpicked a subset of strains that represent all known and predicted peroxisomal proteins as well as proteins that have central roles in peroxisome biology. These smaller collections of strains, mini-libraries, can be rapidly and easily used for complicated screens by any lab. Since one of the libraries is built such that it can be easily modified in the tag, promoter and selection, we also discuss how these collections form the basis for creating a diversity of new peroxisomal libraries for future studies. Using manual tools, available in any yeast lab, coupled with few simple genetic approaches, we will show how these libraries can be "mixed and matched" to create tailor made libraries for screening. These yeast collections may now be exploited to study uncharted territories in the biology of peroxisomes by anyone, anywhere.

Power to the People: End-User Building of Digital Library Collections.

ERIC Educational Resources Information Center

Witten, Ian H.; Bainbridge, David; Boddie, Stefan J.

Digital library systems focus principally on the reader: the consumer of the material that constitutes the library. In contrast, this paper describes an interface that makes it easy for people to build their own library collections. Collections may be built and served locally from the user's own Web server, or (given appropriate permissions)…

Family History and the History of Families

ERIC Educational Resources Information Center

Selleck, R. J. W.

2004-01-01

The State Library of Victoria, which opened its doors in Melbourne in 1856, was designed and built in a confident and expansive decade. Even as war clouds gathered in 1913 the Library's confidence remained strong and it added a magnificent domed reading room, designed with the British Museum Library very much in mind. In the Library's genealogical…

Pre-Service Teachers' Use of Library Databases: Some Insights

ERIC Educational Resources Information Center

Lamb, Janeen; Howard, Sarah; Easey, Michael

2014-01-01

The aim of this study is to investigate if providing mathematics education pre-service teachers with animated library tutorials on library and database searches changes their searching practices. This study involved the completion of a survey by 138 students and seven individual interviews before and after library search demonstration videos were…

Robot Task Commander with Extensible Programming Environment

NASA Technical Reports Server (NTRS)

Hart, Stephen W (Inventor); Wightman, Brian J (Inventor); Dinh, Duy Paul (Inventor); Yamokoski, John D. (Inventor); Gooding, Dustin R (Inventor)

2014-01-01

A system for developing distributed robot application-level software includes a robot having an associated control module which controls motion of the robot in response to a commanded task, and a robot task commander (RTC) in networked communication with the control module over a network transport layer (NTL). The RTC includes a script engine(s) and a GUI, with a processor and a centralized library of library blocks constructed from an interpretive computer programming code and having input and output connections. The GUI provides access to a Visual Programming Language (VPL) environment and a text editor. In executing a method, the VPL is opened, a task for the robot is built from the code library blocks, and data is assigned to input and output connections identifying input and output data for each block. A task sequence(s) is sent to the control module(s) over the NTL to command execution of the task.

PANEL LIBRARY AND EDITOR

NASA Technical Reports Server (NTRS)

Raible, E.

1994-01-01

The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and Editor were released to COSMIC in 1991. Silicon Graphics, IRIS, and IRIX are trademarks of Silicon Graphics, Inc. X-Window System is a trademark of Massachusetts Institute of Technology.

School Libraries and Science Achievement: A View from Michigan's Middle Schools

ERIC Educational Resources Information Center

Mardis, Marcia

2007-01-01

If strong school library media centers (SLMCs) positively impact middle school student reading achievement, as measured on standardized tests, are they also beneficial for middle school science achievement? To answer this question, the researcher built upon the statistical analyses used in previous school library impact studies with qualitative…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Painter, J.; McCormick, P.; Krogh, M.

This paper presents the ACL (Advanced Computing Lab) Message Passing Library. It is a high throughput, low latency communications library, based on Thinking Machines Corp.`s CMMD, upon which message passing applications can be built. The library has been implemented on the Cray T3D, Thinking Machines CM-5, SGI workstations, and on top of PVM.

Hypermedia and Research Methodology: An Associative Research Model. Final Report.

ERIC Educational Resources Information Center

City Univ. of New York, NY. Bernard Baruch Coll.

The purpose of the project described in this three-part report was to test the value of hypermedia for library instruction. The project included the development of a hypermedia program built around a marketing topic; implementation and testing of the program with one group of students assigned to use the new program; evaluation of the project by…

An open-source java platform for automated reaction mapping.

PubMed

Crabtree, John D; Mehta, Dinesh P; Kouri, Tina M

2010-09-27

This article presents software applications that have been built upon a modular, open-source, reaction mapping library that can be used in both cheminformatics and bioinformatics research. We first describe the theoretical underpinnings and modular architecture of the core software library. We then describe two applications that have been built upon that core. The first is a generic reaction viewer and mapper, and the second classifies reactions according to rules that can be modified by end users with little or no programming skills.

Creating a library holding group: an approach to large system integration.

PubMed

Huffman, Isaac R; Martin, Heather J; Delawska-Elliott, Basia

2016-10-01

Faced with resource constraints, many hospital libraries have considered joint operations. This case study describes how Providence Health & Services created a single group to provide library services. Using a holding group model, staff worked to unify more than 6,100 nonlibrary subscriptions and 14 internal library sites. Our library services grew by unifying 2,138 nonlibrary subscriptions and 11 library sites and hiring more library staff. We expanded access to 26,018 more patrons. A model with built-in flexibility allowed successful library expansion. Although challenges remain, this success points to a viable model of unified operations.

Dispensing with the DVD Circulation Dilemma

ERIC Educational Resources Information Center

Ellis, Mark

2008-01-01

Richmond Public Library (RPL) is a four-branch suburban library with the highest per capita circulation of any comparable library in Canada. While DVDs naturally fit into RPL's emphasis on popular material, circulating them using the standard model proved problematic: Long hold queues built up, DVDs idled on the hold shelves, and the circulation…

A New Library for Galway-Mayo Institute of Technology

ERIC Educational Resources Information Center

Kelly, Hugh

2004-01-01

The newly-built library at Ireland's Galway-Mayo Institute of Technology (GMIT) is innovative in design, responds to environmental conditions and identifies the campus with its location. The library is part of the Learning Resource Centre recently constructed to meet the institute's objective for a new landmark frontage. This article presents the…

A Climate of Excellence: Paving the Way for Student Success at Miami-Dade South's Library.

ERIC Educational Resources Information Center

Watters, Robert D.

1986-01-01

Describes Miami-Dade Community College and its librarians. Examines ways South Campus has built, stretched, and promoted the use of library resources. Discusses several student success-oriented strategies; e.g., self-guided cassette tours, "Time Savers" study guides, self-instructional library skills programs, audiovisual productions,…

Foundations of Metrology: Important Early Works on Weights and Measures in the Library of the National Bureau of Standards.

ERIC Educational Resources Information Center

Terner, Janet R.

The purpose of this project was to survey the National Bureau of Standards library holdings of pre-1900 works on metrology and from these, to assemble a special collection of historically important documents. The 265 imprints selected for the collection are listed in this report. Each entry includes the main author, title, imprint, and collation…

An Annotated List of Historically and Scientifically Important Works Published Before 1900 in the Library of The National Bureau of Standards.

ERIC Educational Resources Information Center

Terner, Janet

The purpose of this project was to specifically identify important works within the National Bureau of Standards library collection of approximately 125,000 items that are generally acknowledged to be pertinent to the development of modern science and technology. Presented is an annotated list including 197 items selected from the pre-1900…

12. Historic American Buildings Survey S.F. Chronicle Library, San Francisco ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey S.F. Chronicle Library, San Francisco BUILT 1853 - '4 AFTER THE DISASTER OF 1906 - St. Mary's Church, 660 California Street, San Francisco, San Francisco County, CA

2. Historic American Buildings Survey San Francisco Chronicle Library San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey San Francisco Chronicle Library San Francisco, California Year Built: 1834 Photo Taken: About 1925 VIEW FROM EAST - General Sherman Quarters, 464 Calle Principal, Monterey, Monterey County, CA

SIOExplorer: Modern IT Methods and Tools for Digital Library Management

NASA Astrophysics Data System (ADS)

Sutton, D. W.; Helly, J.; Miller, S.; Chase, A.; Clarck, D.

2003-12-01

With more geoscience disciplines becoming data-driven it is increasingly important to utilize modern techniques for data, information and knowledge management. SIOExplorer is a new digital library project with 2 terabytes of oceanographic data collected over the last 50 years on 700 cruises by the Scripps Institution of Oceanography. It is built using a suite of information technology tools and methods that allow for an efficient and effective digital library management system. The library consists of a number of independent collections, each with corresponding metadata formats. The system architecture allows each collection to be built and uploaded based on a collection dependent metadata template file (MTF). This file is used to create the hierarchical structure of the collection, create metadata tables in a relational database, and to populate object metadata files and the collection as a whole. Collections are comprised of arbitrary digital objects stored at the San Diego Supercomputer Center (SDSC) High Performance Storage System (HPSS) and managed using the Storage Resource Broker (SRB), data handling middle ware developed at SDSC. SIOExplorer interoperates with other collections as a data provider through the Open Archives Initiative (OAI) protocol. The user services for SIOExplorer are accessed from CruiseViewer, a Java application served using Java Web Start from the SIOExplorer home page. CruiseViewer is an advanced tool for data discovery and access. It implements general keyword and interactive geospatial search methods for the collections. It uses a basemap to georeference search results on user selected basemaps such as global topography or crustal age. User services include metadata viewing, opening of selective mime type digital objects (such as images, documents and grid files), and downloading of objects (including the brokering of proprietary hold restrictions).

The Python ARM Radar Toolkit (Py-ART), a library for working with weather radar data in the Python programming language

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helmus, Jonathan J.; Collis, Scott M.

The Python ARM Radar Toolkit is a package for reading, visualizing, correcting and analysing data from weather radars. Development began to meet the needs of the Atmospheric Radiation Measurement Climate Research Facility and has since expanded to provide a general-purpose framework for working with data from weather radars in the Python programming language. The toolkit is built on top of libraries in the Scientific Python ecosystem including NumPy, SciPy, and matplotlib, and makes use of Cython for interfacing with existing radar libraries written in C and to speed up computationally demanding algorithms. As a result, the source code for themore » toolkit is available on GitHub and is distributed under a BSD license.« less

The Python ARM Radar Toolkit (Py-ART), a library for working with weather radar data in the Python programming language

DOE PAGES

Helmus, Jonathan J.; Collis, Scott M.

2016-07-18

The Python ARM Radar Toolkit is a package for reading, visualizing, correcting and analysing data from weather radars. Development began to meet the needs of the Atmospheric Radiation Measurement Climate Research Facility and has since expanded to provide a general-purpose framework for working with data from weather radars in the Python programming language. The toolkit is built on top of libraries in the Scientific Python ecosystem including NumPy, SciPy, and matplotlib, and makes use of Cython for interfacing with existing radar libraries written in C and to speed up computationally demanding algorithms. As a result, the source code for themore » toolkit is available on GitHub and is distributed under a BSD license.« less

DCA_Tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Summers, Michael S

2017-11-08

HPC software for ab-initio, condensed-matter physics, quantum mechanics calculations needs to be built on top of well tested libraries some of which address requirements unique to the programming domain. During the development of the DCA++ code, that we use in our research, we have developed a collection of libraries that may be of use to other computational scientists working in the same or similar domains. The libraries include: a) a pythonic input-language system, b) tensors whose shape is constructed from generalized dimension objects such at time domains. frequency domains, momentum domains, vertex domains et. al. and c) linear algebra operationsmore » that resolve to BLA/LAPACK operations when possible. This supports the implementation of Greens functions and operations on them such as are used in condensed matter physics.« less

SU-E-J-93: Development of Pre-Contoured Human Model Library in DICOM-RT Format for the Epidemiological Study of the Radiotherapy Patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pyakuryal, A; Lee, C; Lee, C

Purpose: Prior to 3D conformal radiation therapy planning, patient anatomy information was mostly limited to 2D beams-eye-view from the conventional simulator. To analyze the outcomes of such treatments for radiation late effects, 3D computational human models are often used in commercial treatment planning systems (TPSs). However, several underlying difficulties such as time-consuming manual delineation procedures of a large number of structures in the model have always limited its applications. Primary objective of this work was to develop a human model library for the epidemiological study by converting 3D-surface model organs to DICOM-RT format (DICOM-RT structure) using an in-house built software.more » We converted the ICRP reference human models to DICOM-RT models, which can be readily adopted for various dose calculations. Methods: MATLAB based code were utilized to convert the contour drawings extracted in text-format from the 3D graphic-tool, Rhinoceros into DICOM-RT structure format for 50 different organs of each model using a 16GB dual-core processor. The conversion periods were measured for each DICOM-RT models, and the reconstructed structure volumes were validated against the original 3D-surface models in the TPS. Ten reference hybrid whole-body models (8-pediatric and 2-adults) were automatically processed to create DICOM-RT computational human model library. Results: Mean contour conversion period was found to be 580 (N=2) and 394.5 (N=8) seconds for 50 organs in the adult and pediatric models respectively. A good agreement for large organs (NRMSD <1.0%) and small organs (NRMSD <7.7%) was also observed between the original volumes and corresponding DICOM-RT structure volumes of the organs. Conclusion: The ICRP reference human models were converted into DICOM-RT format to support the epidemiological study using a large cohort of conventional radiotherapy patients. Due to its DICOM-compatibility, the library may be implemented to many other different applications. We also expect to develop the library by including additional models in future.« less

CADBIT II - Computer-Aided Design for Built-In Test. Volume 1

DTIC Science & Technology

1993-06-01

data provided in the CADBIT I Final Report, as indicated in Figure 1.2. "• CADBIT II IMPLEMENTS SYSTEM CONCEPT, REQUIREMENTS, AND DATA DEVELOPED DURING...CADBIT II software was developed using de facto computer standards including Unix, C, and the X Windows-based OSF/Motif graphical user interface... export connectivity infermation. Design Architect is a package for designers that includes schematic capture, VHDL editor, and libraries of digital

From vision to reality--managing change in the provision of library and information services to nurses, midwives, health visitors and PAMs: (professions allied to medicine) a case study of the North Thames experience with the Inner London Consortium.

PubMed

Godbolt, S; Williamson, J; Wilson, A

1997-06-01

One of the North Thames' pioneering consortia, the Inner London Consortium (ILC) is a complex body which includes NHS Trusts with teaching hospital university connections, community-based Trusts and general hospital acute Trusts. Within the consortium there are 12,000 trained nurses, midwives, health visitors and other professional staff working in the professions allied to medicine (PAMs), all of whom require access to and provision of appropriate library information services. In 1994, taking into account experiences elsewhere in the Region and nationally, it became clear that library issues were complex and would become acute with the move of nursing libraries from ILC Trust sites over a very short timescale. A report on the issues commissioned by the Consortium recommended that a library project, which built on existing NHS Trust PGMDE funded library resources and moved these to a multidisciplinary base to serve the consortium membership, be implemented. The objective of providing access to library information services for nurses and PAMs was achieved. Successes that emerged from the implementation included: The registration in Trust libraries of almost 12 000 new members within the initial 6-month monitoring period. The development of service level agreements and standards for the delivery of services to these new user groups. This paper describes the processes behind these significant and complex changes.

Public library computer training for older adults to access high-quality Internet health information

PubMed Central

Xie, Bo; Bugg, Julie M.

2010-01-01

An innovative experiment to develop and evaluate a public library computer training program to teach older adults to access and use high-quality Internet health information involved a productive collaboration among public libraries, the National Institute on Aging and the National Library of Medicine of the National Institutes of Health (NIH), and a Library and Information Science (LIS) academic program at a state university. One hundred and thirty-one older adults aged 54–89 participated in the study between September 2007 and July 2008. Key findings include: a) participants had overwhelmingly positive perceptions of the training program; b) after learning about two NIH websites (http://nihseniorhealth.gov and http://medlineplus.gov) from the training, many participants started using these online resources to find high quality health and medical information and, further, to guide their decision-making regarding a health- or medically-related matter; and c) computer anxiety significantly decreased (p < .001) while computer interest and efficacy significantly increased (p = .001 and p < .001, respectively) from pre- to post-training, suggesting statistically significant improvements in computer attitudes between pre- and post-training. The findings have implications for public libraries, LIS academic programs, and other organizations interested in providing similar programs in their communities. PMID:20161649

Pharmit: interactive exploration of chemical space.

PubMed

Sunseri, Jocelyn; Koes, David Ryan

2016-07-08

Pharmit (http://pharmit.csb.pitt.edu) provides an online, interactive environment for the virtual screening of large compound databases using pharmacophores, molecular shape and energy minimization. Users can import, create and edit virtual screening queries in an interactive browser-based interface. Queries are specified in terms of a pharmacophore, a spatial arrangement of the essential features of an interaction, and molecular shape. Search results can be further ranked and filtered using energy minimization. In addition to a number of pre-built databases of popular compound libraries, users may submit their own compound libraries for screening. Pharmit uses state-of-the-art sub-linear algorithms to provide interactive screening of millions of compounds. Queries typically take a few seconds to a few minutes depending on their complexity. This allows users to iteratively refine their search during a single session. The easy access to large chemical datasets provided by Pharmit simplifies and accelerates structure-based drug design. Pharmit is available under a dual BSD/GPL open-source license. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Working without a Crystal Ball: Predicting Web Trends for Web Services Librarians

ERIC Educational Resources Information Center

Ovadia, Steven

2008-01-01

User-centered design is a principle stating that electronic resources, like library Web sites, should be built around the needs of the users. This article interviews Web developers of library and non-library-related Web sites, determining how they assess user needs and how they decide to adapt certain technologies for users. According to the…

Library Information Made to Order: An Open Source Project Built for and with Librarians

ERIC Educational Resources Information Center

Griggs, Kim

2009-01-01

Oregon State University (OSU) libraries, where the author serves as lead programmer, have developed a tool to make it easier for librarians to build and maintain interactive course assignment pages (ICAPs) and subject research guides (SRGs). That tool, Library a la Carte, enables librarians with minimal technical expertise to create dynamic…

Moving Digital Libraries into the Student Learning Space: The GetSmart Experience

ERIC Educational Resources Information Center

Marshall, Byron B.; Chen, Hsinchun; Shen, Rao; Fox, Edward A.

2006-01-01

The GetSmart system was built to support theoretically sound learning processes in a digital library environment by integrating course management, digital library, and concept mapping components to support a constructivist, six-step, information search process. In the fall of 2002 more than 100 students created 1400 concept maps as part of…

Experiences Using an Open Source Software Library to Teach Computer Vision Subjects

ERIC Educational Resources Information Center

Cazorla, Miguel; Viejo, Diego

2015-01-01

Machine vision is an important subject in computer science and engineering degrees. For laboratory experimentation, it is desirable to have a complete and easy-to-use tool. In this work we present a Java library, oriented to teaching computer vision. We have designed and built the library from the scratch with emphasis on readability and…

Fac-Back-OPAC: An Open Source Interface to Your Library System

ERIC Educational Resources Information Center

Beccaria, Mike; Scott, Dan

2007-01-01

The new Fac-Back-OPAC (a faceted backup OPAC) is built on code that was originally developed by Casey Durfee in February 2007. It represents the convergence of two prominent trends in library tools: the decoupling of discovery tools from the traditional integrated library system (ILS) and the use of readily available open source components to…

The Case for Home-Grown, Sustainable, Next Generation Library Services

ERIC Educational Resources Information Center

Haefele, Chad

2011-01-01

While libraries offer next generation public services such as mobile access and e-books, these services are often neither home-grown nor sustainable. Libraries have a history of lending and services built on a simple model: they purchase an item and then provide it to the community. Unfortunately, the latest generation of services offered by…

Plagiarism Awareness among Students: Assessing Integration of Ethics Theory into Library Instruction

ERIC Educational Resources Information Center

Strittmatter, Connie; Bratton, Virginia K.

2014-01-01

The library literature on plagiarism instruction focuses on students' understanding of what plagiarism is and is not. This study evaluates the effect of library instruction from a broader perspective by examining the pre- and posttest (instruction) levels of students' perceptions toward plagiarism ethics. Eighty-six students completed a pre- and…

voevent-parse: Parse, manipulate, and generate VOEvent XML packets

NASA Astrophysics Data System (ADS)

Staley, Tim D.

2014-11-01

voevent-parse, written in Python, parses, manipulates, and generates VOEvent XML packets; it is built atop lxml.objectify. Details of transients detected by many projects, including Fermi, Swift, and the Catalina Sky Survey, are currently made available as VOEvents, which is also the standard alert format by future facilities such as LSST and SKA. However, working with XML and adhering to the sometimes lengthy VOEvent schema can be a tricky process. voevent-parse provides convenience routines for common tasks, while allowing the user to utilise the full power of the lxml library when required. An earlier version of voevent-parse was part of the pysovo (ascl:1411.002) library.

Practical Implementation of Semi-Automated As-Built Bim Creation for Complex Indoor Environments

NASA Astrophysics Data System (ADS)

Yoon, S.; Jung, J.; Heo, J.

2015-05-01

In recent days, for efficient management and operation of existing buildings, the importance of as-built BIM is emphasized in AEC/FM domain. However, fully automated as-built BIM creation is a tough issue since newly-constructed buildings are becoming more complex. To manage this problem, our research group has developed a semi-automated approach, focusing on productive 3D as-built BIM creation for complex indoor environments. In order to test its feasibility for a variety of complex indoor environments, we applied the developed approach to model the `Charlotte stairs' in Lotte World Mall, Korea. The approach includes 4 main phases: data acquisition, data pre-processing, geometric drawing, and as-built BIM creation. In the data acquisition phase, due to its complex structure, we moved the scanner location several times to obtain the entire point clouds of the test site. After which, data pre-processing phase entailing point-cloud registration, noise removal, and coordinate transformation was followed. The 3D geometric drawing was created using the RANSAC-based plane detection and boundary tracing methods. Finally, in order to create a semantically-rich BIM, the geometric drawing was imported into the commercial BIM software. The final as-built BIM confirmed that the feasibility of the proposed approach in the complex indoor environment.

The Impact of Library Tutorials on the Information Literacy Skills of Occupational Therapy and Physical Therapy Students in an Evidence-Based Practice Course: A Rubric Assessment.

PubMed

Schweikhard, April J; Hoberecht, Toni; Peterson, Alyssa; Randall, Ken

2018-01-01

This study measures how online library instructional tutorials implemented into an evidence-based practice course have impacted the information literacy skills of occupational and physical therapy graduate students. Through a rubric assessment of final course papers, this study compares differences in students' search strategies and cited sources pre- and post-implementation of the tutorials. The population includes 180 randomly selected graduate students from before and after the library tutorials were introduced into the course curriculum. Results indicate a statistically significant increase in components of students' searching skills and ability to find higher levels of evidence after completing the library tutorials.

Tardive Dyskinesia

MedlinePlus

... Supplements Peer Review Process Review Committees Application Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of ... Supplements Peer Review Process Review Committees Application Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of ...

Hemicrania Continua

MedlinePlus

... Supplements Peer Review Process Review Committees Application Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of ... Supplements Peer Review Process Review Committees Application Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of ...

Benign Essential Blepharospasm

MedlinePlus

... Supplements Peer Review Process Review Committees Application Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of ... Supplements Peer Review Process Review Committees Application Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of ...

Effective e-Training: Using a Course Management System and e-Learning Tools to Train Library Employees

ERIC Educational Resources Information Center

See, Andrew; Teetor, Travis Stephen

2014-01-01

In the summer of 2012, the University of Arizona Libraries implemented an online training program to effectively train Access Services staff and student employees at a large academic research library. This article discusses the program, which was built using a course management system (D2L) and various e-Learning software applications (Articulate…

The Context for Planning: A Report to the Jackson-George Regional Library System.

ERIC Educational Resources Information Center

McCook, Kathleen de la Pena; And Others

This report describes a study of the Jackson-George Regional Library (JGRL) System, which serves a 2-county area in Mississippi with a population of 131,918. The purpose of the study, which built on the planning and administration goals identified in "Planning for Progress: The Long Range Plan of the Jackson George Regional Library," was to…

Building an Online Library for Interpretation Training: Explorations into an Effective Blended-Learning Mode

ERIC Educational Resources Information Center

Chan, Clara Ho-yan

2014-01-01

This paper reports on a blended-learning project that aims to develop a web-based library of interpreting practice resources built on the course management system Blackboard for Hong Kong interpretation students to practise outside the classroom. It also evaluates the library's effectiveness for learning, based on a case study that uses it to…

The Approval-Built Collection in the Medium-Sized Academic Library

ERIC Educational Resources Information Center

DeVilbiss, Mary Lee

1975-01-01

Compares the approval-built collection with the collection which is created when traditional select and order procedures are used. The study was limited to 1974 imprints in four subject areas and utilized the services of two major vendors. (Author)

LibHalfSpace: A C++ object-oriented library to study deformation and stress in elastic half-spaces

NASA Astrophysics Data System (ADS)

Ferrari, Claudio; Bonafede, Maurizio; Belardinelli, Maria Elina

2016-11-01

The study of deformation processes in elastic half-spaces is widely employed for many purposes (e.g. didactic, scientific investigation of real processes, inversion of geodetic data, etc.). We present a coherent programming interface containing a set of tools designed to make easier and faster the study of processes in an elastic half-space. LibHalfSpace is presented in the form of an object-oriented library. A set of well known and frequently used source models (Mogi source, penny shaped horizontal crack, inflating spheroid, Okada rectangular dislocation, etc.) are implemented to describe the potential usage and the versatility of the library. The common interface given to library tools enables us to switch easily among the effects produced by different deformation sources that can be monitored at the free surface. Furthermore, the library also offers an interface which simplifies the creation of new source models exploiting the features of object-oriented programming (OOP). These source models can be built as distributions of rectangular boundary elements. In order to better explain how new models can be deployed some examples are included in the library.

[Physiology in the mirror of systematic catalogue of Russian Academy of Sciences Library].

PubMed

Orlov, I V; Lazurkina, V B

2011-07-01

Representation of general human and animal physiology publications in the systematic catalogue of the Library of the Russian Academy of Sciences is considered. The organization of the catalogue as applied to the problems of physiology, built on the basis of library-bibliographic classification used in the Russian universal scientific libraries is described. The card files of the systematic catalogue of the Library contain about 8 million cards. Topics that reflect the problems of general physiology contain 39 headings. For the full range of sciences including physiology the tables of general types of divisions were developed. They have been marked by indexes using lower-case letters of the Russian alphabet. For further detalizations of these indexes decimal symbols are used. The indexes are attached directly to the field of knowledge index. With the current relatively easy availability of network resources value and relevance of any catalogue are reduced. However it concerns much more journal articles, rather than reference books, proceedings of various conferences, bibliographies, personalities, and especially the monographs contained in the systematic catalogue. The card systematic catalogue of the Library remains an important source of information on general physiology issues, as well as its magistral narrower sections.

Reading in the Clouds: Building a Library at a School in India.

ERIC Educational Resources Information Center

Khalsa, Gurupreet K.

2000-01-01

Describes how, over three years, teachers, students, parents, and administrators of a girls' school in India built a school library, going from a small locked-up collection with no check-out system to a warm and busy library room that was a popular hub of activity at the school, with a dynamic and expanding collection and a full-time librarian.…

Putting "Service" into Library Staff Training: A Library Manager's Training Guide. LAMA Occasional Papers Series. A Patron-Centered Guide.

ERIC Educational Resources Information Center

Bessler, Joanne M.

This guide is built on librarianship training literature and customer service research from a variety of professions. It tells library managers how to identify and describe service ideals, to translate these ideals into realistic goals, and to lead new and experienced staff in fulfilling these service ideals. They are encouraged to focus the…

Planning library spaces to encourage collaboration

PubMed Central

Adamson, Martha C.; Bunnett, Brian P.

2002-01-01

Most librarians can give examples from their own experience in which a library's physical space was either ill suited to the work to be performed or, in some unfortunate cases, a genuine barrier to productivity. In an effort to correct or avoid these situations, planners of library renovations or new construction make pre-design studies of individual workers' tasks and workflow at the work-unit level. In this article, the authors discuss how a pre-design review of library and institutional values influenced the course of a library renovation. The identification of collaboration as the major theme of the library and the institution's strategic directions drove renovation decisions and resulted in a facility that supports and promotes this concept. PMID:12398250

Hierarchy and extremes in selections from pools of randomized proteins

PubMed Central

Boyer, Sébastien; Biswas, Dipanwita; Kumar Soshee, Ananda; Scaramozzino, Natale; Nizak, Clément; Rivoire, Olivier

2016-01-01

Variation and selection are the core principles of Darwinian evolution, but quantitatively relating the diversity of a population to its capacity to respond to selection is challenging. Here, we examine this problem at a molecular level in the context of populations of partially randomized proteins selected for binding to well-defined targets. We built several minimal protein libraries, screened them in vitro by phage display, and analyzed their response to selection by high-throughput sequencing. A statistical analysis of the results reveals two main findings. First, libraries with the same sequence diversity but built around different “frameworks” typically have vastly different responses; second, the distribution of responses of the best binders in a library follows a simple scaling law. We show how an elementary probabilistic model based on extreme value theory rationalizes the latter finding. Our results have implications for designing synthetic protein libraries, estimating the density of functional biomolecules in sequence space, characterizing diversity in natural populations, and experimentally investigating evolvability (i.e., the potential for future evolution). PMID:26969726

Hierarchy and extremes in selections from pools of randomized proteins.

PubMed

Boyer, Sébastien; Biswas, Dipanwita; Kumar Soshee, Ananda; Scaramozzino, Natale; Nizak, Clément; Rivoire, Olivier

2016-03-29

Variation and selection are the core principles of Darwinian evolution, but quantitatively relating the diversity of a population to its capacity to respond to selection is challenging. Here, we examine this problem at a molecular level in the context of populations of partially randomized proteins selected for binding to well-defined targets. We built several minimal protein libraries, screened them in vitro by phage display, and analyzed their response to selection by high-throughput sequencing. A statistical analysis of the results reveals two main findings. First, libraries with the same sequence diversity but built around different "frameworks" typically have vastly different responses; second, the distribution of responses of the best binders in a library follows a simple scaling law. We show how an elementary probabilistic model based on extreme value theory rationalizes the latter finding. Our results have implications for designing synthetic protein libraries, estimating the density of functional biomolecules in sequence space, characterizing diversity in natural populations, and experimentally investigating evolvability (i.e., the potential for future evolution).

CSlib, a library to couple codes via Client/Server messaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plimpton, Steve

The CSlib is a small, portable library which enables two (or more) independent simulation codes to be coupled, by exchanging messages with each other. Both codes link to the library when they are built, and can them communicate with each other as they run. The messages contain data or instructions that the two codes send back-and-forth to each other. The messaging can take place via files, sockets, or MPI. The latter is a standard distributed-memory message-passing library.

Delivering customized apps, multimedia and NASA data to libraries and their patrons

NASA Astrophysics Data System (ADS)

Harold, J. B.; Dusenbery, P.; Holland, A.; LaConte, K.; Johnson, A.; Randall, C.; Fitzhugh, G.

2017-12-01

With funding through NASA's Science Mission Directorate, the NASA @ My Library project has been working with the public library community to enhance the STEM literacy of library patrons throughout the nation. One element of the project is to disseminate a variety of materials to 75 partner libraries in order to support their implementation of hands-on, NASA related STEM activities for their patrons. These materials range from very low tech (UV beads) to high tech (a 4.5" Orion Dobsonian telescope), and include an 8" tablet. This tablet provides us with a wide range of possibilities for delivering NASA content. Besides NASA multimedia and real-time spacecraft data, the tablets can be used for interactive activities, including public apps as well as apps specifically designed for this program, such as a green screen app that incorporates NASA imagery as part of a larger storytelling activity. The tablets also include a full sensor suite (magnetometer, light sensor, accelerometer, etc.), allowing us to develop library activities that use the tablet as a measuring device - detecting magnetism in a "Meteorite or Wrong" activity, or using the light sensor as a transit device. The tablet is centrally managed and includes a "kiosk mode", allowing the libraries to use it in either a locked down or conventional mode. The management system also allows us to create a curated collection of apps and multimedia, push out updated software, and collect analytics data on how the tablet is being used. In this presentation we will discuss the library pre-survey that guided our tablet development process, as well as our lessons learned to date, including the practicality and effectiveness of deploying tablets at this scale, their ability to support NASA specific STEM efforts, and what we have learned about library usage.

Preparing Pre-Service School Librarians for Science-Focused Collaboration with Pre-Service Elementary Teachers: The Design and Impact of a Cross-Class Assignment

ERIC Educational Resources Information Center

Rawson, Casey H.

2015-01-01

Numerous authors in the library and information science (LIS) field have called for more authentic collaborative experiences for students in school librarian education programs, particularly experiences that partner school library students with pre-service teachers to collaboratively design instruction. The first-iteration, design-based study…

14. Photocopy of pre1956 photograph. Original in library of John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of pre-1956 photograph. Original in library of John S. Lehmann Building, Missouri Botanical Garden. CEILING, SHOWING ORIGINAL SKYLIGHT NOW PLASTERED OVER - Missouri Botanical Garden, Museum, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

22. Photocopy of pre1891 photograph. Original in library of Lehmann ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photocopy of pre-1891 photograph. Original in library of Lehmann Building, Missouri Botanical Garden. HOUSE ON ORIGINAL SITE, SHOWING SOUTH WING STUCCOED - Missouri Botanical Garden, Henry Shaw Townhouse, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

Kip, Version 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Staley, Martin

2017-09-20

This high-performance ray tracing library provides very fast rendering; compact code; type flexibility through C++ "generic programming" techniques; and ease of use via an application programming interface (API) that operates independently of any GUI, on-screen display, or other enclosing application. Kip supports constructive solid geometry (CSG) models based on a wide variety of built-in shapes and logical operators, and also allows for user-defined shapes and operators to be provided. Additional features include basic texturing; input/output of models using a simple human-readable file format and with full error checking and detailed diagnostics; and support for shared data parallelism. Kip is writtenmore » in pure, ANSI standard C++; is entirely platform independent; and is very easy to use. As a C++ "header only" library, it requires no build system, configuration or installation scripts, wizards, non-C++ preprocessing, makefiles, shell scripts, or external libraries.« less

SU-G-BRB-02: An Open-Source Software Analysis Library for Linear Accelerator Quality Assurance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerns, J; Yaldo, D

Purpose: Routine linac quality assurance (QA) tests have become complex enough to require automation of most test analyses. A new data analysis software library was built that allows physicists to automate routine linear accelerator quality assurance tests. The package is open source, code tested, and benchmarked. Methods: Images and data were generated on a TrueBeam linac for the following routine QA tests: VMAT, starshot, CBCT, machine logs, Winston Lutz, and picket fence. The analysis library was built using the general programming language Python. Each test was analyzed with the library algorithms and compared to manual measurements taken at the timemore » of acquisition. Results: VMAT QA results agreed within 0.1% between the library and manual measurements. Machine logs (dynalogs & trajectory logs) were successfully parsed; mechanical axis positions were verified for accuracy and MLC fluence agreed well with EPID measurements. CBCT QA measurements were within 10 HU and 0.2mm where applicable. Winston Lutz isocenter size measurements were within 0.2mm of TrueBeam’s Machine Performance Check. Starshot analysis was within 0.2mm of the Winston Lutz results for the same conditions. Picket fence images with and without a known error showed that the library was capable of detecting MLC offsets within 0.02mm. Conclusion: A new routine QA software library has been benchmarked and is available for use by the community. The library is open-source and extensible for use in larger systems.« less

Creating Open Source Conversation

ERIC Educational Resources Information Center

Sheehan, Kate

2009-01-01

Darien Library, where the author serves as head of knowledge and learning services, launched a new website on September 1, 2008. The website is built with Drupal, an open source content management system (CMS). In this article, the author describes how she and her colleagues overhauled the library's website to provide an open source content…

A Kid-Built Classroom Library. Curriculum Boosters. Technology.

ERIC Educational Resources Information Center

Cooper, Laurie K.

1994-01-01

Elementary students can help turn the classroom book collection into a well-organized library using the classroom computer. In the process, they get practice in cooperative-learning groups as they work with both electronic and card catalogs. The article explains how to use computers to create an electronic catalog. (SM)

An object-oriented class library for medical software development.

PubMed

O'Kane, K C; McColligan, E E

1996-12-01

The objective of this research is the development of a Medical Object Library (MOL) consisting of reusable, inheritable, portable, extendable C++ classes that facilitate rapid development of medical software at reduced cost and increased functionality. The result of this research is a library of class objects that range in function from string and hierarchical file handling entities to high level, procedural agents that perform increasingly complex, integrated tasks. A system built upon these classes is compatible with any other system similarly constructed with respect to data definitions, semantics, data organization and storage. As new objects are built, they can be added to the class library for subsequent use. The MOL is a toolkit of software objects intended to support a common file access methodology, a unified medical record structure, consistent message processing, standard graphical display facilities and uniform data collection procedures. This work emphasizes the relationship that potentially exists between the structure of a hierarchical medical record and procedural language components by means of a hierarchical class library and tree structured file access facility. In doing so, it attempts to establish interest in and demonstrate the practicality of the hierarchical medical record model in the modern context of object oriented programming.

21. Photocopy of pre1891 photograph. Original in library of Lehmann ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Photocopy of pre-1891 photograph. Original in library of Lehmann Building, Missouri Botanical Garden. EAST AND NORTH WALLS OF HOUSE ON ORIGINAL SITE AT SEVENTH AND LOCUST STREETS - Missouri Botanical Garden, Henry Shaw Townhouse, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

The Potential of CGI: Using Pre-Built CGI Scripts to Make Interactive Web Pages.

ERIC Educational Resources Information Center

Nackerud, Shane A.

1998-01-01

Describes CGI (Common Gateway Interface) scripts that are available on the Web and explains how librarians can use them to make Web pages more interactive. Topics include CGI security; Perl scripts; UNIX; and HTML. (LRW)

Health sciences library building projects: 1995 survey.

PubMed Central

Ludwig, L

1996-01-01

The Medical Library Association's fifth annual survey of recent health sciences library building projects identified twenty-five libraries planning, expanding, or constructing new library facilities. None of the fifteen new library projects are free standing structures; however, several occupy a major portion of the project space. Ten projects involve renovation of or addition to existing space. Information regarding size, cost of project, type of construction, completion date, and other factual data was provided for twelve projects. The remaining identified projects are in pre-design or early-design stages, or are awaiting funding approval. Library building projects for three hospital libraries, three academic medical libraries, and an association library are described. Each illustrates how considerations of economics and technology are changing the traditional library model from a centrally stored information depository housing a wide range of information under one roof where users come to the information, into an electronic model gradually shifting from investment in the physical presence of resources to investment in creating work space for creditible information specialists who help in-house and distanced users to obtain information electronically from any place and at any time. This new model includes a highly skilled library team to manage, filter, and package the information to users trained by these resident experts. Images PMID:8883981

Health sciences library building projects: 1995 survey.

PubMed

Ludwig, L

1996-07-01

The Medical Library Association's fifth annual survey of recent health sciences library building projects identified twenty-five libraries planning, expanding, or constructing new library facilities. None of the fifteen new library projects are free standing structures; however, several occupy a major portion of the project space. Ten projects involve renovation of or addition to existing space. Information regarding size, cost of project, type of construction, completion date, and other factual data was provided for twelve projects. The remaining identified projects are in pre-design or early-design stages, or are awaiting funding approval. Library building projects for three hospital libraries, three academic medical libraries, and an association library are described. Each illustrates how considerations of economics and technology are changing the traditional library model from a centrally stored information depository housing a wide range of information under one roof where users come to the information, into an electronic model gradually shifting from investment in the physical presence of resources to investment in creating work space for creditible information specialists who help in-house and distanced users to obtain information electronically from any place and at any time. This new model includes a highly skilled library team to manage, filter, and package the information to users trained by these resident experts.

Teaching as a Political Act: Critical Pedagogy in Library Instruction

ERIC Educational Resources Information Center

Fritch, Melia Erin

2018-01-01

This article establishes a theoretical framework for critical library instruction (and thereby critical information literacy) that is built upon critical feminist theory, critical race theory, and engaged pedagogy, among others. Using the ideas and work of theorists to create a path linking the ideas of critical analyses together, the author…

Children of the Book: Parents, Bedtime, and Jewish Identity

ERIC Educational Resources Information Center

Alexander, Shelley T.

2013-01-01

This article offers a conceptual framework for assessing PJ Library programming grounded in the relevant scholarly literature and illustrated by way of conversations with PJ Library parents. It is built around three themes concerning how parents view their role as facilitators in their child's religious and cultural identity formation through the…

User Engagement with Digital Archives for Research and Teaching: A Case Study of "Emblematica Online"

ERIC Educational Resources Information Center

Green, Harriett E.; Lamprin, Patricia

2017-01-01

Researchers increasingly engage with the digital archives built by libraries, archives, and museums, but many institutions still seek to learn more about researchers' needs and practices with these digital collections. This paper presents a user assessment study for "Emblematica Online," a research digital library that provides digitized…

INTRIGOSS: A new Library of High Resolution Synthetic Spectra

NASA Astrophysics Data System (ADS)

Franchini, Mariagrazia; Morossi, Carlo; Di Marcancantonio, Paolo; Chavez, Miguel; GES-Builders

2018-01-01

INTRIGOSS (INaf Trieste Grid Of Synthetic Spectra) is a new High Resolution (HiRes) synthetic spectral library designed for studying F, G, and K stars. The library is based on atmosphere models computed with specified individual element abundances via ATLAS12 code. Normalized SPectra (NSP) and surface Flux SPectra (FSP), in the 4800-5400 Å wavelength range, were computed by means of the SPECTRUM code. The synthetic spectra are computed with an atomic and bi-atomic molecular line list including "bona fide" Predicted Lines (PLs) built by tuning loggf to reproduce very high SNR Solar spectrum and the UVES-U580 spectra of five cool giants extracted from the Gaia-ESO survey (GES). The astrophysical gf-values were then assessed by using more than 2000 stars with homogenous and accurate atmosphere parameters and detailed chemical composition from GES. The validity and greater accuracy of INTRIGOSS NSPs and FSPs with respect to other available spectral libraries is discussed. INTRIGOSS will be available on the web and will be a valuable tool for both stellar atmospheric parameters and stellar population studies.

Building and Managing Electronic Resources in Digital Era in India with Special Reference to IUCAA and NIV, Pune: A Comparative Case Study

NASA Astrophysics Data System (ADS)

Sahu, H. K.; Singh, S. N.

2015-04-01

This paper discusses and presents a comparative case study of two libraries in Pune, India, Inter-University Centre for Astronomy and Astrophysics and Information Centre and Library of National Institute of Virology (Indian Council of Medical Research). It compares how both libraries have managed their e-resource collections, including acquisitions, subscriptions, and consortia arrangements, while also developing a collection of their own resources, including pre-prints and publications, video lectures, and other materials in an institutional repository. This study illustrates how difficult it is to manage electronic resources in a developing country like India, even though electronic resources are used more than print resources. Electronic resource management can be daunting, but with a systematic approach, various problems can be solved, and use of the materials will be enhanced.

Examining the Association between the "Imagination Library" Early Childhood Literacy Program and Kindergarten Readiness

ERIC Educational Resources Information Center

Samiei, Shahin; Bush, Andrew J.; Sell, Marie; Imig, Doug

2016-01-01

This study evaluated participation in the "Imagination Library" early childhood literacy enrichment program and children's pre-literacy and pre-numeracy skills at kindergarten entry in an urban school district. Previous studies have demonstrated that program participation is associated with greater early childhood reading practices.…

Critical Features of Fragment Libraries for Protein Structure Prediction

PubMed Central

dos Santos, Karina Baptista

2017-01-01

The use of fragment libraries is a popular approach among protein structure prediction methods and has proven to substantially improve the quality of predicted structures. However, some vital aspects of a fragment library that influence the accuracy of modeling a native structure remain to be determined. This study investigates some of these features. Particularly, we analyze the effect of using secondary structure prediction guiding fragments selection, different fragments sizes and the effect of structural clustering of fragments within libraries. To have a clearer view of how these factors affect protein structure prediction, we isolated the process of model building by fragment assembly from some common limitations associated with prediction methods, e.g., imprecise energy functions and optimization algorithms, by employing an exact structure-based objective function under a greedy algorithm. Our results indicate that shorter fragments reproduce the native structure more accurately than the longer. Libraries composed of multiple fragment lengths generate even better structures, where longer fragments show to be more useful at the beginning of the simulations. The use of many different fragment sizes shows little improvement when compared to predictions carried out with libraries that comprise only three different fragment sizes. Models obtained from libraries built using only sequence similarity are, on average, better than those built with a secondary structure prediction bias. However, we found that the use of secondary structure prediction allows greater reduction of the search space, which is invaluable for prediction methods. The results of this study can be critical guidelines for the use of fragment libraries in protein structure prediction. PMID:28085928

Critical Features of Fragment Libraries for Protein Structure Prediction.

PubMed

Trevizani, Raphael; Custódio, Fábio Lima; Dos Santos, Karina Baptista; Dardenne, Laurent Emmanuel

2017-01-01

The use of fragment libraries is a popular approach among protein structure prediction methods and has proven to substantially improve the quality of predicted structures. However, some vital aspects of a fragment library that influence the accuracy of modeling a native structure remain to be determined. This study investigates some of these features. Particularly, we analyze the effect of using secondary structure prediction guiding fragments selection, different fragments sizes and the effect of structural clustering of fragments within libraries. To have a clearer view of how these factors affect protein structure prediction, we isolated the process of model building by fragment assembly from some common limitations associated with prediction methods, e.g., imprecise energy functions and optimization algorithms, by employing an exact structure-based objective function under a greedy algorithm. Our results indicate that shorter fragments reproduce the native structure more accurately than the longer. Libraries composed of multiple fragment lengths generate even better structures, where longer fragments show to be more useful at the beginning of the simulations. The use of many different fragment sizes shows little improvement when compared to predictions carried out with libraries that comprise only three different fragment sizes. Models obtained from libraries built using only sequence similarity are, on average, better than those built with a secondary structure prediction bias. However, we found that the use of secondary structure prediction allows greater reduction of the search space, which is invaluable for prediction methods. The results of this study can be critical guidelines for the use of fragment libraries in protein structure prediction.

Using Mobile App Development Tools to Build a GIS Application

NASA Astrophysics Data System (ADS)

Mital, A.; Catchen, M.; Mital, K.

2014-12-01

Our group designed and built working web, android, and IOS applications using different mapping libraries as bases on which to overlay fire data from NASA. The group originally planned to make app versions for Google Maps, Leaflet, and OpenLayers. However, because the Leaflet library did not properly load on Android, the group focused efforts on the other two mapping libraries. For Google Maps, the group first designed a UI for the web app and made a working version of the app. After updating the source of fire data to one which also provided historical fire data, the design had to be modified to include the extra data. After completing a working version of the web app, the group used webview in android, a built in resource which allowed porting the web app to android without rewriting the code for android. Upon completing this, the group found Apple IOS devices had a similar capability, and so decided to add an IOS app to the project using a function similar to webview. Alongside this effort, the group began implementing an OpenLayers fire map using a simpler UI. This web app was completed fairly quickly relative to Google Maps; however, it did not include functionality such as satellite imagery or searchable locations. The group finished the project with a working android version of the Google Maps based app supporting API levels 14-19 and an OpenLayers based app supporting API levels 8-19, as well as a Google Maps based IOS app supporting both old and new screen formats. This project was implemented by high school and college students under an SGT Inc. STEM internship program

Tracking How Science Resources Result in Educator- and Community-Level Outcomes

NASA Astrophysics Data System (ADS)

Dusenbery, P.; Harold, J. B.; Fitzhugh, G.; LaConte, K.; Holland, A.

2017-12-01

Learners frequently need to access increasingly complex information to help them understand our changing world. More and more libraries are transforming themselves into places where learners not only access STEM information, but interact with professionals and undertake hands-on learning. Libraries are beginning to position themselves as part of learning ecosystems that contribute to a collective impact on the community. Traveling STEM exhibits are catalyzing these partnerships and engaging students, families, and adults in repeat visits through an accessible venue: their public library. This talk will explore impacts from two STAR Library Network's (STAR_Net) exhibitions (Discover Earth and Discover Tech) on partnerships, the circulation of STEM resources, and the engagement of learners. The STAR_Net project's summative evaluation utilized mixed methods to investigate project implementation and its outcomes. Methods included pre- and post-exhibit surveys administered to staff from each library that hosted the exhibits; interviews with staff from host libraries; patron surveys; exhibit-related circulation records; web metrics regarding the online STAR_Net community of practice; and site visits. The latter provides a more complete view of impacts on the community, including underserved audiences. NASA@ My Library is a new STAR_Net initiative, which provides STEM facilitation kits, training, and other resources to 75 libraries nationwide. Initial results will be presented that show high levels of engagement by librarians and strong response rate from patrons on surveys.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, David; Klise, Katherine A.

The PyEPANET package is a set of commands for the Python programming language that are built to wrap the EPANET toolkit library commands, without requiring the end user to program using the ctypes package. This package does not contain the EPANET code, nor does it implement the functions within the EPANET software, and it requires the separately downloaded or compiled EPANET2 toolkit dynamic library (epanet.dll, libepanent.so, or epanet.dylib) and/or the EPANET-MSX dynamic library in order to function.

Open source Matrix Product States: Opening ways to simulate entangled many-body quantum systems in one dimension

NASA Astrophysics Data System (ADS)

Jaschke, Daniel; Wall, Michael L.; Carr, Lincoln D.

2018-04-01

Numerical simulations are a powerful tool to study quantum systems beyond exactly solvable systems lacking an analytic expression. For one-dimensional entangled quantum systems, tensor network methods, amongst them Matrix Product States (MPSs), have attracted interest from different fields of quantum physics ranging from solid state systems to quantum simulators and quantum computing. Our open source MPS code provides the community with a toolset to analyze the statics and dynamics of one-dimensional quantum systems. Here, we present our open source library, Open Source Matrix Product States (OSMPS), of MPS methods implemented in Python and Fortran2003. The library includes tools for ground state calculation and excited states via the variational ansatz. We also support ground states for infinite systems with translational invariance. Dynamics are simulated with different algorithms, including three algorithms with support for long-range interactions. Convenient features include built-in support for fermionic systems and number conservation with rotational U(1) and discrete Z2 symmetries for finite systems, as well as data parallelism with MPI. We explain the principles and techniques used in this library along with examples of how to efficiently use the general interfaces to analyze the Ising and Bose-Hubbard models. This description includes the preparation of simulations as well as dispatching and post-processing of them.

jSPyDB, an open source database-independent tool for data management

NASA Astrophysics Data System (ADS)

Pierro, Giuseppe Antonio; Cavallari, Francesca; Di Guida, Salvatore; Innocente, Vincenzo

2011-12-01

Nowadays, the number of commercial tools available for accessing Databases, built on Java or .Net, is increasing. However, many of these applications have several drawbacks: usually they are not open-source, they provide interfaces only with a specific kind of database, they are platform-dependent and very CPU and memory consuming. jSPyDB is a free web-based tool written using Python and Javascript. It relies on jQuery and python libraries, and is intended to provide a simple handler to different database technologies inside a local web browser. Such a tool, exploiting fast access libraries such as SQLAlchemy, is easy to install, and to configure. The design of this tool envisages three layers. The front-end client side in the local web browser communicates with a backend server. Only the server is able to connect to the different databases for the purposes of performing data definition and manipulation. The server makes the data available to the client, so that the user can display and handle them safely. Moreover, thanks to jQuery libraries, this tool supports export of data in different formats, such as XML and JSON. Finally, by using a set of pre-defined functions, users are allowed to create their customized views for a better data visualization. In this way, we optimize the performance of database servers by avoiding short connections and concurrent sessions. In addition, security is enforced since we do not provide users the possibility to directly execute any SQL statement.

The mzqLibrary – An open source Java library supporting the HUPO‐PSI quantitative proteomics standard

PubMed Central

Zhang, Huaizhong; Fan, Jun; Perkins, Simon; Pisconti, Addolorata; Simpson, Deborah M.; Bessant, Conrad; Hubbard, Simon; Jones, Andrew R.

2015-01-01

The mzQuantML standard has been developed by the Proteomics Standards Initiative for capturing, archiving and exchanging quantitative proteomic data, derived from mass spectrometry. It is a rich XML‐based format, capable of representing data about two‐dimensional features from LC‐MS data, and peptides, proteins or groups of proteins that have been quantified from multiple samples. In this article we report the development of an open source Java‐based library of routines for mzQuantML, called the mzqLibrary, and associated software for visualising data called the mzqViewer. The mzqLibrary contains routines for mapping (peptide) identifications on quantified features, inference of protein (group)‐level quantification values from peptide‐level values, normalisation and basic statistics for differential expression. These routines can be accessed via the command line, via a Java programming interface access or a basic graphical user interface. The mzqLibrary also contains several file format converters, including import converters (to mzQuantML) from OpenMS, Progenesis LC‐MS and MaxQuant, and exporters (from mzQuantML) to other standards or useful formats (mzTab, HTML, csv). The mzqViewer contains in‐built routines for viewing the tables of data (about features, peptides or proteins), and connects to the R statistical library for more advanced plotting options. The mzqLibrary and mzqViewer packages are available from https://code.google.com/p/mzq‐lib/. PMID:26037908

The mzqLibrary--An open source Java library supporting the HUPO-PSI quantitative proteomics standard.

PubMed

Qi, Da; Zhang, Huaizhong; Fan, Jun; Perkins, Simon; Pisconti, Addolorata; Simpson, Deborah M; Bessant, Conrad; Hubbard, Simon; Jones, Andrew R

2015-09-01

The mzQuantML standard has been developed by the Proteomics Standards Initiative for capturing, archiving and exchanging quantitative proteomic data, derived from mass spectrometry. It is a rich XML-based format, capable of representing data about two-dimensional features from LC-MS data, and peptides, proteins or groups of proteins that have been quantified from multiple samples. In this article we report the development of an open source Java-based library of routines for mzQuantML, called the mzqLibrary, and associated software for visualising data called the mzqViewer. The mzqLibrary contains routines for mapping (peptide) identifications on quantified features, inference of protein (group)-level quantification values from peptide-level values, normalisation and basic statistics for differential expression. These routines can be accessed via the command line, via a Java programming interface access or a basic graphical user interface. The mzqLibrary also contains several file format converters, including import converters (to mzQuantML) from OpenMS, Progenesis LC-MS and MaxQuant, and exporters (from mzQuantML) to other standards or useful formats (mzTab, HTML, csv). The mzqViewer contains in-built routines for viewing the tables of data (about features, peptides or proteins), and connects to the R statistical library for more advanced plotting options. The mzqLibrary and mzqViewer packages are available from https://code.google.com/p/mzq-lib/. © 2015 The Authors. PROTEOMICS Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sirepo for Synchrotron Radiation Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagler, Robert; Moeller, Paul; Rakitin, Maksim

Sirepo is an open source framework for cloud computing. The graphical user interface (GUI) for Sirepo, also known as the client, executes in any HTML5 compliant web browser on any computing platform, including tablets. The client is built in JavaScript, making use of the following open source libraries: Bootstrap, which is fundamental for cross-platform web applications; AngularJS, which provides a model–view–controller (MVC) architecture and GUI components; and D3.js, which provides interactive plots and data-driven transformations. The Sirepo server is built on the following Python technologies: Flask, which is a lightweight framework for web development; Jinja, which is a secure andmore » widely used templating language; and Werkzeug, a utility library that is compliant with the WSGI standard. We use Nginx as the HTTP server and proxy, which provides a scalable event-driven architecture. The physics codes supported by Sirepo execute inside a Docker container. One of the codes supported by Sirepo is the Synchrotron Radiation Workshop (SRW). SRW computes synchrotron radiation from relativistic electrons in arbitrary magnetic fields and propagates the radiation wavefronts through optical beamlines. SRW is open source and is primarily supported by Dr. Oleg Chubar of NSLS-II at Brookhaven National Laboratory.« less

Interface for the documentation and compilation of a library of computer models in physiology.

PubMed Central

Summers, R. L.; Montani, J. P.

1994-01-01

A software interface for the documentation and compilation of a library of computer models in physiology was developed. The interface is an interactive program built within a word processing template in order to provide ease and flexibility of documentation. A model editor within the interface directs the model builder as to standardized requirements for incorporating models into the library and provides the user with an index to the levels of documentation. The interface and accompanying library are intended to facilitate model development, preservation and distribution and will be available for public use. PMID:7950046

Practical Strategies for Making Online Library Services and Instruction Accessible to All Patrons

ERIC Educational Resources Information Center

Wray, Christina C.

2013-01-01

Providing accessible library services and instruction to distance users with disabilities can seem daunting. This article, which grew out of a webinar presented by the author to the Health Science Special Interest Group of ACRL, provides practical strategies to help content creators utilize built-in accessibility features and provides a resources…

Thin Client Architecture for Networking CD-ROMs in a Medium-Sized Public Library System.

ERIC Educational Resources Information Center

Turner, Anna

1997-01-01

Describes how the Tulsa City-County Library System built a 22-branch CD-ROM-based network with the emerging thin-client/server technology, and succeeded in providing patrons with the most current research tools and information resources available. Discusses costs; networking options; the Citrix WinFrame system used; equipment and connectivity.…

Data Manipulation in an XML-Based Digital Image Library

ERIC Educational Resources Information Center

Chang, Naicheng

2005-01-01

Purpose: To help to clarify the role of XML tools and standards in supporting transition and migration towards a fully XML-based environment for managing access to information. Design/methodology/approach: The Ching Digital Image Library, built on a three-tier architecture, is used as a source of examples to illustrate a number of methods of data…

Albany v. 3.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salinger, Andrew; Phipps, Eric; Ostien, Jakob

2016-01-13

The Albany code is a general-purpose finite element code for solving partial differential equations (PDEs). Albany is a research code that demonstrates how a PDE code can be built by interfacing many of the open-source software libraries that are released under Sandia's Trilinos project. Part of the mission of Albany is to be a testbed for new Trilinos libraries, to refine their methods, usability, and interfaces. Albany includes hooks to optimization and uncertainty quantification algorithms, including those in Trilinos as well as those in the Dakota toolkit. Because of this, Albany is a desirable starting point for new code developmentmore » efforts that wish to make heavy use of Trilinos. Albany is both a framework and the host for specific finite element applications. These applications have project names, and can be controlled by configuration option when the code is compiled, but are all developed and released as part of the single Albany code base, These include LCM, QCAD, FELIX, Aeras, and ATO applications.« less

The Computerization of the National Library in Paris.

ERIC Educational Resources Information Center

Lerin, Christian; Bernard, Annick

1986-01-01

Describes the organization and automation plan of the Bibliotheque Nationale (Paris, France) that was begun in 1981. Highlights include the method of moving toward computerization; technical choices; the choosing procedure (pre-qualification, bench-mark test); short term and pilot operations; and preparation for the implementation of the…

Planning a new library in an age of transition: the Washington University School of Medicine Library and Biomedical Communications Center.

PubMed Central

Crawford, S; Halbrook, B

1990-01-01

In an era of great technological and socioeconomic changes, the Washington University School of Medicine conceptualized and built its first Library and Biomedical Communications Center in seventy-eight years. The planning process, evolution of the electronic library, and translation of functions into operating spaces are discussed. Since 1983, when the project was approved, a whole range of information technologies and services have emerged. The authors consider the kind of library that would operate in a setting where people can do their own searches, order data and materials through an electronic network, analyze and manage information, and use software to create their own publications. Images PMID:2393757

PandaEPL: a library for programming spatial navigation experiments.

PubMed

Solway, Alec; Miller, Jonathan F; Kahana, Michael J

2013-12-01

Recent advances in neuroimaging and neural recording techniques have enabled researchers to make significant progress in understanding the neural mechanisms underlying human spatial navigation. Because these techniques generally require participants to remain stationary, computer-generated virtual environments are used. We introduce PandaEPL, a programming library for the Python language designed to simplify the creation of computer-controlled spatial-navigation experiments. PandaEPL is built on top of Panda3D, a modern open-source game engine. It allows users to construct three-dimensional environments that participants can navigate from a first-person perspective. Sound playback and recording and also joystick support are provided through the use of additional optional libraries. PandaEPL also handles many tasks common to all cognitive experiments, including managing configuration files, logging all internal and participant-generated events, and keeping track of the experiment state. We describe how PandaEPL compares with other software for building spatial-navigation experiments and walk the reader through the process of creating a fully functional experiment.

PandaEPL: A library for programming spatial navigation experiments

PubMed Central

Solway, Alec; Miller, Jonathan F.

2013-01-01

Recent advances in neuroimaging and neural recording techniques have enabled researchers to make significant progress in understanding the neural mechanisms underlying human spatial navigation. Because these techniques generally require participants to remain stationary, computer-generated virtual environments are used. We introduce PandaEPL, a programming library for the Python language designed to simplify the creation of computer-controlled spatial-navigation experiments. PandaEPL is built on top of Panda3D, a modern open-source game engine. It allows users to construct three-dimensional environments that participants can navigate from a first-person perspective. Sound playback and recording and also joystick support are provided through the use of additional optional libraries. PandaEPL also handles many tasks common to all cognitive experiments, including managing configuration files, logging all internal and participant-generated events, and keeping track of the experiment state. We describe how PandaEPL compares with other software for building spatial-navigation experiments and walk the reader through the process of creating a fully functional experiment. PMID:23549683

Library of Giant Planet Reflection Spectra for WFirst and Future Space Telescopes

NASA Astrophysics Data System (ADS)

Smith, Adam J. R. W.; Fortney, Jonathan; Morley, Caroline; Batalha, Natasha E.; Lewis, Nikole K.

2018-01-01

Future large space space telescopes will be able to directly image exoplanets in optical light. The optical light of a resolved planet is due to stellar flux reflected by Rayleigh scattering or cloud scattering, with absorption features imprinted due to molecular bands in the planetary atmosphere. To aid in the design of such missions, and to better understand a wide range of giant planet atmospheres, we have built a library of model giant planet reflection spectra, for the purpose of determining effective methods of spectral analysis as well as for comparison with actual imaged objects. This library covers a wide range of parameters: objects are modeled at ten orbital distances between 0.5 AU and 5.0 AU, which ranges from planets too warm for water clouds, out to those that are true Jupiter analogs. These calculations include six metalicities between solar and 100x solar, with a variety of different cloud thickness parameters, and across all possible phase angles.

Using leap motion to investigate the emergence of structure in speech and language.

PubMed

Eryilmaz, Kerem; Little, Hannah

2017-10-01

 In evolutionary linguistics, experiments using artificial signal spaces are being used to investigate the emergenceof speech structure. These signal spaces need to be continuous, non-discretized spaces from which discrete unitsand patterns can emerge. They need to be dissimilar from-but comparable with-the vocal tract, in order tominimize interference from pre-existing linguistic knowledge, while informing us about language. This is a hardbalance to strike. This article outlines a new approach that uses the Leap Motion, an infrared controller that canconvert manual movement in 3d space into sound. The signal space using this approach is more flexible than signalspaces in previous attempts. Further, output data using this approach is simpler to arrange and analyze. Theexperimental interface was built using free, and mostly open- source libraries in Python. We provide our sourcecode for other researchers as open source.

Installing the Unix Starlink Software

NASA Astrophysics Data System (ADS)

Bly, M. J.

This note is the release note and installation instructions for the DEC Alpha AXP / Digital UNIX, Sun Sparc / Solaris v2.x, and Sun Sparc / SunOS 4.1.x versions of the Starlink Software Collection (USSC). You will be supplied with pre-built (and installed) versions on tape and will just need to copy the tape to disk to have a working version. The tapes (where appropriate) will contain in addition, copies of the NAG and MEMSYS libraries, and Tcl, Tk, Expect, Mosaic, TeX, Pine, Perl, Jed, Ispell, Ghostscript, LaXeX2html and Ftnchek for the relevant system. The Sun Sparc SunOS 4.1.x version of the USSC was frozen at USSC111 and no further updates are available. The instructions for installing the main section of the USSC may continue to be used for installing Sun Sparc SunOS 4.1.x version.

Free Oscilloscope Web App Using a Computer Mic, Built-In Sound Library, or Your Own Files

ERIC Educational Resources Information Center

Ball, Edward; Ruiz, Frances; Ruiz, Michael J.

2017-01-01

We have developed an online oscilloscope program which allows users to see waveforms by utilizing their computer microphones, selecting from our library of over 30 audio files, and opening any *.mp3 or *.wav file on their computers. The oscilloscope displays real-time signals against time. The oscilloscope has been calibrated so one can make…

The Dynamo package for tomography and subtomogram averaging: components for MATLAB, GPU computing and EC2 Amazon Web Services

PubMed Central

Castaño-Díez, Daniel

2017-01-01

Dynamo is a package for the processing of tomographic data. As a tool for subtomogram averaging, it includes different alignment and classification strategies. Furthermore, its data-management module allows experiments to be organized in groups of tomograms, while offering specialized three-dimensional tomographic browsers that facilitate visualization, location of regions of interest, modelling and particle extraction in complex geometries. Here, a technical description of the package is presented, focusing on its diverse strategies for optimizing computing performance. Dynamo is built upon mbtools (middle layer toolbox), a general-purpose MATLAB library for object-oriented scientific programming specifically developed to underpin Dynamo but usable as an independent tool. Its structure intertwines a flexible MATLAB codebase with precompiled C++ functions that carry the burden of numerically intensive operations. The package can be delivered as a precompiled standalone ready for execution without a MATLAB license. Multicore parallelization on a single node is directly inherited from the high-level parallelization engine provided for MATLAB, automatically imparting a balanced workload among the threads in computationally intense tasks such as alignment and classification, but also in logistic-oriented tasks such as tomogram binning and particle extraction. Dynamo supports the use of graphical processing units (GPUs), yielding considerable speedup factors both for native Dynamo procedures (such as the numerically intensive subtomogram alignment) and procedures defined by the user through its MATLAB-based GPU library for three-dimensional operations. Cloud-based virtual computing environments supplied with a pre-installed version of Dynamo can be publicly accessed through the Amazon Elastic Compute Cloud (EC2), enabling users to rent GPU computing time on a pay-as-you-go basis, thus avoiding upfront investments in hardware and longterm software maintenance. PMID:28580909

The Dynamo package for tomography and subtomogram averaging: components for MATLAB, GPU computing and EC2 Amazon Web Services.

PubMed

Castaño-Díez, Daniel

2017-06-01

Dynamo is a package for the processing of tomographic data. As a tool for subtomogram averaging, it includes different alignment and classification strategies. Furthermore, its data-management module allows experiments to be organized in groups of tomograms, while offering specialized three-dimensional tomographic browsers that facilitate visualization, location of regions of interest, modelling and particle extraction in complex geometries. Here, a technical description of the package is presented, focusing on its diverse strategies for optimizing computing performance. Dynamo is built upon mbtools (middle layer toolbox), a general-purpose MATLAB library for object-oriented scientific programming specifically developed to underpin Dynamo but usable as an independent tool. Its structure intertwines a flexible MATLAB codebase with precompiled C++ functions that carry the burden of numerically intensive operations. The package can be delivered as a precompiled standalone ready for execution without a MATLAB license. Multicore parallelization on a single node is directly inherited from the high-level parallelization engine provided for MATLAB, automatically imparting a balanced workload among the threads in computationally intense tasks such as alignment and classification, but also in logistic-oriented tasks such as tomogram binning and particle extraction. Dynamo supports the use of graphical processing units (GPUs), yielding considerable speedup factors both for native Dynamo procedures (such as the numerically intensive subtomogram alignment) and procedures defined by the user through its MATLAB-based GPU library for three-dimensional operations. Cloud-based virtual computing environments supplied with a pre-installed version of Dynamo can be publicly accessed through the Amazon Elastic Compute Cloud (EC2), enabling users to rent GPU computing time on a pay-as-you-go basis, thus avoiding upfront investments in hardware and longterm software maintenance.

Building capacity in a health sciences library to support global health projects.

PubMed

Lackey, Mellanye; Swogger, Susan; McGraw, Kathleen A

2014-04-01

This paper describes how a large, academic health sciences library built capacity for supporting global health at its university and discusses related outcomes. Lean budgets require prioritization and organizational strategy. A committee, with leadership responsibilities assigned to one librarian, guided strategic planning and the pursuit of collaborative, global health outreach activities. A website features case studies and videos of user stories to promote how library partnerships successfully contributed to global health projects. Collaborative partnerships were formed through outreach activities and from follow-up to reference questions. The committee and a librarian's dedicated time established the library's commitment to help the university carry out its ambitious global agenda.

Expressions Module for the Satellite Orbit Analysis Program

NASA Technical Reports Server (NTRS)

Edmonds, Karina

2008-01-01

The Expressions Module is a software module that has been incorporated into the Satellite Orbit Analysis Program (SOAP). The module includes an expressions- parser submodule built on top of an analytical system, enabling the user to define logical and numerical variables and constants. The variables can capture output from SOAP orbital-prediction and geometric-engine computations. The module can combine variables and constants with built-in logical operators (such as Boolean AND, OR, and NOT), relational operators (such as >, <, or =), and mathematical operators (such as addition, subtraction, multiplication, division, modulus, exponentiation, differentiation, and integration). Parentheses can be used to specify precedence of operations. The module contains a library of mathematical functions and operations, including logarithms, trigonometric functions, Bessel functions, minimum/ maximum operations, and floating- point-to-integer conversions. The module supports combinations of time, distance, and angular units and has a dimensional- analysis component that checks for correct usage of units. A parser based on the Flex language and the Bison program looks for and indicates errors in syntax. SOAP expressions can be built using other expressions as arguments, thus enabling the user to build analytical trees. A graphical user interface facilitates use.

40 CFR Appendix A to Subpart I of... - Determination of Allowable Costs

Code of Federal Regulations, 2010 CFR

2010-07-01

... the actual reasonable and necessary costs for preparing the pre-bid package. (4) Post-construction... built in conformance with the design drawings and specifications. f. The costs (including legal... from defects in the plans, design drawings and specifications, or other subagreement documents only to...

40 CFR Appendix A to Subpart I of... - Determination of Allowable Costs

Code of Federal Regulations, 2012 CFR

2012-07-01

... the actual reasonable and necessary costs for preparing the pre-bid package. (4) Post-construction... built in conformance with the design drawings and specifications. f. The costs (including legal... from defects in the plans, design drawings and specifications, or other subagreement documents only to...

40 CFR Appendix A to Subpart I of... - Determination of Allowable Costs

Code of Federal Regulations, 2011 CFR

2011-07-01

... the actual reasonable and necessary costs for preparing the pre-bid package. (4) Post-construction... built in conformance with the design drawings and specifications. f. The costs (including legal... from defects in the plans, design drawings and specifications, or other subagreement documents only to...

Federal Pre-White House Conference on Library and Information Services Proceedings (Bethesda, Maryland, November 26-27, 1990).

ERIC Educational Resources Information Center

Federal Library and Information Center Committee, Washington, DC.

This report presents the recommendations and proceedings of the Federal Pre-White House Conference on Library and Information Services (WHCLIS II) in two sections. Thirteen issues and recommendations of high national priority identified by the federal delegates to the WHCLIS II are provided in the first section: (1) Preservation Plan for Federal…

Architecture and Initial Development of a Digital Library Platform for Computable Knowledge Objects for Health.

PubMed

Flynn, Allen J; Bahulekar, Namita; Boisvert, Peter; Lagoze, Carl; Meng, George; Rampton, James; Friedman, Charles P

2017-01-01

Throughout the world, biomedical knowledge is routinely generated and shared through primary and secondary scientific publications. However, there is too much latency between publication of knowledge and its routine use in practice. To address this latency, what is actionable in scientific publications can be encoded to make it computable. We have created a purpose-built digital library platform to hold, manage, and share actionable, computable knowledge for health called the Knowledge Grid Library. Here we present it with its system architecture.

47 CFR 54.505 - Discounts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SERVICE Universal Service Support for Schools and Libraries § 54.505 Discounts. (a) Discount mechanism. Discounts for eligible schools and libraries shall be set as a percentage discount from the pre-discount price. (b) Discount percentages. The discounts available to eligible schools and libraries shall range...

47 CFR 54.505 - Discounts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICE Universal Service Support for Schools and Libraries § 54.505 Discounts. (a) Discount mechanism. Discounts for eligible schools and libraries shall be set as a percentage discount from the pre-discount price. (b) Discount percentages. The discounts available to eligible schools and libraries shall range...

Assessment of PCXMC for patients with different body size in chest and abdominal x ray examinations: a Monte Carlo simulation study.

PubMed

Borrego, David; Lowe, Erin M; Kitahara, Cari M; Lee, Choonsik

2018-03-21

A PC Program for x ray Monte Carlo (PCXMC) has been used to calculate organ doses in patient dosimetry and for the exposure assessment in epidemiological studies of radiogenic health related risks. This study compared the dosimetry from using the built-in stylized phantoms in the PCXMC to that of a newer hybrid phantom library with improved anatomical realism. We simulated chest and abdominal x ray projections for 146 unique body size computational phantoms, 77 males and 69 females, with different combinations of height (125-180 cm) and weight (20-140 kg) using the built-in stylized phantoms in the PCXMC version 2.0.1.4 and the hybrid phantom library using the Monte Carlo N-particle eXtended transport code 2.7 (MCNPX). Unfortunately, it was not possible to incorporate the hybrid phantom library into the PCXMC. We compared 14 organ doses, including dose to the active bone marrow, to evaluate differences between the built-in stylized phantoms in the PCXMC and the hybrid phantoms (Cristy and Eckerman 1987 Technical Report ORNL/TM-8381/V1, Oak Ridge National Laboratory, Eckerman and Ryman 1993 Technical Report 12 Oak Ridge, TN, Geyer et al 2014 Phys. Med. Biol. 59 5225-42). On average, organ doses calculated using the built-in stylized phantoms in the PCXMC were greater when compared to the hybrid phantoms. This is most prominent in AP abdominal exams by an average factor of 2.4-, 2.8-, and 2.8-fold for the 10-year-old, 15-year-old, and adult phantoms, respectively. For chest exams, organ doses are greater by an average factor of 1.1-, 1.4-, and 1.2-fold for the 10-year-old, 15-year-old, and adult phantoms, respectively. The PCXMX, due to its ease of use, is often selected to support dosimetry in epidemiological studies; however, it uses simplified models of the human anatomy that fail to account for variations in body morphometry for increasing weight. For epidemiological studies that use PCXMC dosimetry, associations between radiation-related disease risks and organ doses may be underestimated, and to a greater degree in pediatric, especially obese pediatric, compared to adult patients.

Assessment of PCXMC for patients with different body size in chest and abdominal x ray examinations: a Monte Carlo simulation study

NASA Astrophysics Data System (ADS)

Borrego, David; Lowe, Erin M.; Kitahara, Cari M.; Lee, Choonsik

2018-03-01

A PC Program for x ray Monte Carlo (PCXMC) has been used to calculate organ doses in patient dosimetry and for the exposure assessment in epidemiological studies of radiogenic health related risks. This study compared the dosimetry from using the built-in stylized phantoms in the PCXMC to that of a newer hybrid phantom library with improved anatomical realism. We simulated chest and abdominal x ray projections for 146 unique body size computational phantoms, 77 males and 69 females, with different combinations of height (125–180 cm) and weight (20–140 kg) using the built-in stylized phantoms in the PCXMC version 2.0.1.4 and the hybrid phantom library using the Monte Carlo N-particle eXtended transport code 2.7 (MCNPX). Unfortunately, it was not possible to incorporate the hybrid phantom library into the PCXMC. We compared 14 organ doses, including dose to the active bone marrow, to evaluate differences between the built-in stylized phantoms in the PCXMC and the hybrid phantoms (Cristy and Eckerman 1987 Technical Report ORNL/TM-8381/V1, Oak Ridge National Laboratory, Eckerman and Ryman 1993 Technical Report 12 Oak Ridge, TN, Geyer et al 2014 Phys. Med. Biol. 59 5225–42). On average, organ doses calculated using the built-in stylized phantoms in the PCXMC were greater when compared to the hybrid phantoms. This is most prominent in AP abdominal exams by an average factor of 2.4-, 2.8-, and 2.8-fold for the 10-year-old, 15-year-old, and adult phantoms, respectively. For chest exams, organ doses are greater by an average factor of 1.1-, 1.4-, and 1.2-fold for the 10-year-old, 15-year-old, and adult phantoms, respectively. The PCXMX, due to its ease of use, is often selected to support dosimetry in epidemiological studies; however, it uses simplified models of the human anatomy that fail to account for variations in body morphometry for increasing weight. For epidemiological studies that use PCXMC dosimetry, associations between radiation-related disease risks and organ doses may be underestimated, and to a greater degree in pediatric, especially obese pediatric, compared to adult patients.

Extending OPeNDAP's Data-Access Protocol to Include Enhanced Pre-Retrieval Operations

NASA Astrophysics Data System (ADS)

Fulker, D. W.

2013-12-01

We describe plans to extend OPeNDAP's Web-services protocol as a Building Block for NSF's EarthCube initiative. Though some data-access services have offered forms of subset-selection for decades, other pre-retrieval operations have been unavailable, in part because their benefits (over equivalent post-retrieval actions) are only now becoming fully evident. This is due in part to rapid growth in the volumes of data that are pertinent to the geosciences, exacerbated by limitations such as Internet speeds and latencies as well as pressures toward data usage on ever-smaller devices. In this context, as recipients of a "Building Blocks" award from the most recent round of EarthCube funding, we are launching the specification and prototype implementation of a new Open Data Services Invocation Protocol (ODSIP), by which clients may invoke a newly rich set of data-acquisition services, ranging from statistical summarization and criteria-driven subsetting to re-gridding/resampling. ODSIP will be an extension to DAP4, the latest version of OPeNDAP's widely used data access protocol, which underpins a number of open-source, multilingual, client-server systems (offering data access as a Web service), including THREDDS, PyDAP, GrADS, ERDAP and FERRET, as well as OPeNDAP's own Hyrax servers. We are motivated by the idea that key parts of EarthCube can be built effectively around clients and servers that employ a common and conceptually rich protocol for data acquisition. This concept extends 'data provision' to include pre-retrieval operations that, even when invoked by remote clients, exhibit efficiencies of data-proximate computation. Our aim for ODSIP is to embed a largely domain-neutral algebra of server functions that, despite being deliberately compact, can fulfill a broad range of user needs for pre-retrieval operations. To that end, our approach builds upon languages and tools that have proven effective in multi-domain contexts, and we will employ a user-centered design process built around three science scenarios: 1) accelerated visualization/analysis of model outputs on non-rectangular meshes (over coastal North Carolina); 2) dynamic downscaling of climate predictions for regional utility (over Hawaii); and 3) feature-oriented retrievals of satellite imagery (focusing on satellite-derived sea-surface-temperature fronts). These scenarios will test important aspects of the server-function algebra: * The Hawaii climate study requires coping with issues of scale on rectangular grids, placing strong emphasis on statistical functions. * The east-coast storm-surge study requires irregular grids, thus exploring mathematical challenges that have been addressed in many domains via the GridFields library, which we will employ. We think important classes of geoscience problems in multiple domains--where dealing with discontinuities, for example--are essentially intractable without polygonal meshes. * The sea-surface fronts study integrates vector-style features with array-style coverages, thus touching on the kinds of mathematics that arise when mixing Eulerian and Lagrangian frameworks. Our presentation will sketch the context for ODSIP, our process for a user-centered design, and our hopes for how ODSIP, as an emerging cyberinfrastructure concept for the Geosciences, may serve as a fundamental building block for EarthCube.

Through the Eyes of the Preservice Teacher: Using a Reflective Reading Journey to Inform Teaching and Learning

ERIC Educational Resources Information Center

Gibson, Karen M.

2010-01-01

Many factors affect attitudes toward reading, including parent and other caretaker support, sibling attitudes, school and library programs, curriculum and instruction, and, of course, teachers. While working with preservice teachers pursuing licensure in pre-kindergarten through adolescent education, it became evident that the students had many…

Identifying MicroRNAs and Transcript Targets in Jatropha Seeds

PubMed Central

Galli, Vanessa; Guzman, Frank; de Oliveira, Luiz F. V.; Loss-Morais, Guilherme; Körbes, Ana P.; Silva, Sérgio D. A.; Margis-Pinheiro, Márcia M. A. N.; Margis, Rogério

2014-01-01

MicroRNAs, or miRNAs, are endogenously encoded small RNAs that play a key role in diverse plant biological processes. Jatropha curcas L. has received significant attention as a potential oilseed crop for the production of renewable oil. Here, a sRNA library of mature seeds and three mRNA libraries from three different seed development stages were generated by deep sequencing to identify and characterize the miRNAs and pre-miRNAs of J. curcas. Computational analysis was used for the identification of 180 conserved miRNAs and 41 precursors (pre-miRNAs) as well as 16 novel pre-miRNAs. The predicted miRNA target genes are involved in a broad range of physiological functions, including cellular structure, nuclear function, translation, transport, hormone synthesis, defense, and lipid metabolism. Some pre-miRNA and miRNA targets vary in abundance between the three stages of seed development. A search for sequences that produce siRNA was performed, and the results indicated that J. curcas siRNAs play a role in nuclear functions, transport, catalytic processes and disease resistance. This study presents the first large scale identification of J. curcas miRNAs and their targets in mature seeds based on deep sequencing, and it contributes to a functional understanding of these miRNAs. PMID:24551031

Building capacity in a health sciences library to support global health projects*

PubMed Central

Lackey, Mellanye; Swogger, Susan; McGraw, Kathleen A.

2014-01-01

This paper describes how a large, academic health sciences library built capacity for supporting global health at its university and discusses related outcomes. Lean budgets require prioritization and organizational strategy. A committee, with leadership responsibilities assigned to one librarian, guided strategic planning and the pursuit of collaborative, global health outreach activities. A website features case studies and videos of user stories to promote how library partnerships successfully contributed to global health projects. Collaborative partnerships were formed through outreach activities and from follow-up to reference questions. The committee and a librarian's dedicated time established the library's commitment to help the university carry out its ambitious global agenda. PMID:24860264

High yield of functional metagenomic library from mangroves constructed in fosmid vector.

PubMed

Gonçalves, A C S; dos Santos, A C F; dos Santos, T F; Pessoa, T B A; Dias, J C T; Rezende, R P

2015-10-02

In the present study, metagenomic technique and fosmid vectors were used to construct a library of clones for exploring the biotechnological potential of mangrove soils by isolation of functional genes encoding hydrolytic enzymes. The library was built with genomic DNA from the soil samples of mangrove sediments and the functional screening of 1824 clones (~64 Mbp) was performed to detect the hydrolytic activity specific for cellulases, amylases (at acidic, neutral and basic pH), lipases/esterases, proteases, and nitrilases. Significant numbers of clones, positive for the tested enzyme activities were obtained. Our results indicate the importance and biotechnological potential of mangrove soils especially when compared to those obtained using other soil metagenomic libraries.

EMPIRE: Nuclear Reaction Model Code System for Data Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herman, M.; Capote, R.; Carlson, B.V.

EMPIRE is a modular system of nuclear reaction codes, comprising various nuclear models, and designed for calculations over a broad range of energies and incident particles. A projectile can be a neutron, proton, any ion (including heavy-ions) or a photon. The energy range extends from the beginning of the unresolved resonance region for neutron-induced reactions ({approx} keV) and goes up to several hundred MeV for heavy-ion induced reactions. The code accounts for the major nuclear reaction mechanisms, including direct, pre-equilibrium and compound nucleus ones. Direct reactions are described by a generalized optical model (ECIS03) or by the simplified coupled-channels approachmore » (CCFUS). The pre-equilibrium mechanism can be treated by a deformation dependent multi-step direct (ORION + TRISTAN) model, by a NVWY multi-step compound one or by either a pre-equilibrium exciton model with cluster emission (PCROSS) or by another with full angular momentum coupling (DEGAS). Finally, the compound nucleus decay is described by the full featured Hauser-Feshbach model with {gamma}-cascade and width-fluctuations. Advanced treatment of the fission channel takes into account transmission through a multiple-humped fission barrier with absorption in the wells. The fission probability is derived in the WKB approximation within the optical model of fission. Several options for nuclear level densities include the EMPIRE-specific approach, which accounts for the effects of the dynamic deformation of a fast rotating nucleus, the classical Gilbert-Cameron approach and pre-calculated tables obtained with a microscopic model based on HFB single-particle level schemes with collective enhancement. A comprehensive library of input parameters covers nuclear masses, optical model parameters, ground state deformations, discrete levels and decay schemes, level densities, fission barriers, moments of inertia and {gamma}-ray strength functions. The results can be converted into ENDF-6 formatted files using the accompanying code EMPEND and completed with neutron resonances extracted from the existing evaluations. The package contains the full EXFOR (CSISRS) library of experimental reaction data that are automatically retrieved during the calculations. Publication quality graphs can be obtained using the powerful and flexible plotting package ZVView. The graphic user interface, written in Tcl/Tk, provides for easy operation of the system. This paper describes the capabilities of the code, outlines physical models and indicates parameter libraries used by EMPIRE to predict reaction cross sections and spectra, mainly for nucleon-induced reactions. Selected applications of EMPIRE are discussed, the most important being an extensive use of the code in evaluations of neutron reactions for the new US library ENDF/B-VII.0. Future extensions of the system are outlined, including neutron resonance module as well as capabilities of generating covariances, using both KALMAN and Monte-Carlo methods, that are still being advanced and refined.« less

PreCam Survey Work at ANL

Science.gov Websites

- Astrophysics - DES - PreCam PreCam Work at ANL The Argonne/HEP Dark Energy Survey (DES) group, working on the Dark Energy Camera (DECam), built a mini-DECam camera called PreCam. This camera has provided valuable

Development of bacterial display peptides for use in biosensing applications

NASA Astrophysics Data System (ADS)

Stratis-Cullum, Dimitra N.; Kogot, Joshua M.; Sellers, Michael S.; Hurley, Margaret M.; Sarkes, Deborah A.; Pennington, Joseph M.; Val-Addo, Irene; Adams, Bryn L.; Warner, Candice R.; Carney, James P.; Brown, Rebecca L.; Pellegrino, Paul M.

2012-06-01

Recent advances in synthetic library engineering continue to show promise for the rapid production of reagent technology in response to biological threats. A synthetic library of peptide mutants built off a bacterial host offers a convenient means to link the peptide sequence, (i.e., identity of individual library members) with the desired molecular recognition traits, but also allows for a relatively simple protocol, amenable to automation. An improved understanding of the mechanisms of recognition and control of synthetic reagent isolation and evolution remain critical to success. In this paper, we describe our approach to development of peptide affinity reagents based on peptide bacterial display technology with improved control of binding interactions for stringent evolution of reagent candidates, and tailored performance capabilities. There are four key elements to the peptide affinity reagent program including: (1) the diverse bacterial library technology, (2) advanced reagent screening amenable to laboratory automation and control, (3) iterative characterization and feedback on both affinity and specificity of the molecular interactions, and (3) integrated multiscale computational prescreening of candidate peptide ligands including in silico prediction of improved binding performance. Specific results on peptides binders to Protective Antigen (PA) protein of Bacillus anthracis and Staphylococcal Enterotoxin B (SEB) will be presented. Recent highlights of on cell vs. off-cell affinity behavior and correlation of the results with advanced docking simulations on the protein-peptide system(s) are included. The potential of this technology and approach to enable rapid development of a new affinity reagent with unprecedented speed (less than one week) would allow for rapid response to new and constantly emerging threats.

Copyright Issues Relevant to Digital Preservation and Dissemination of Pre-1972 Commercial Sound Recordings by Libraries and Archives. CLIR Publication No. 135

ERIC Educational Resources Information Center

Besek, June M.

2005-01-01

This report addresses the question of what libraries and archives are legally empowered to do to preserve and make accessible for research their holdings of pre-1972 commercial recordings, the large aural legacy that is not protected by federal copyright. The report is one of a series of studies undertaken by the National Recording Preservation…

Copyright and Related Issues Relevant to Digital Preservation and Dissemination of Unpublished Pre-1972 Sound Recordings by Libraries and Archives. CLIR Publication No. 144

ERIC Educational Resources Information Center

Besek, June M.

2009-01-01

This report addresses the question of what libraries and archives are legally empowered to do to preserve and make accessible for research their holdings of unpublished pre-1972 sound recordings. The report's author, June M. Besek, is executive director of the Kernochan Center for Law, Media and the Arts at Columbia Law School. Unpublished sound…

Search without Boundaries Using Simple APIs

USGS Publications Warehouse

Tong, Qi

2009-01-01

The U.S. Geological Survey (USGS) Library, where the author serves as the digital services librarian, is increasingly challenged to make it easier for users to find information from many heterogeneous information sources. Information is scattered throughout different software applications (i.e., library catalog, federated search engine, link resolver, and vendor websites), and each specializes in one thing. How could the library integrate the functionalities of one application with another and provide a single point of entry for users to search across? To improve the user experience, the library launched an effort to integrate the federated search engine into the library's intranet website. The result is a simple search box that leverages the federated search engine's built-in application programming interfaces (APIs). In this article, the author describes how this project demonstrated the power of APIs and their potential to be used by other enterprise search portals inside or outside of the library.

Federal Funding Alternatives. White House Conference on Library and Information Services: Pre-Conference Meetings on Special Themes, June 8-9 and September 14, 1978.

ERIC Educational Resources Information Center

Trezza, Alphonse F.

Existing and potential federal funding programs for libraries are discussed in this special conference theme summary. The relation of library funding to the total intergovernmental grant system is explained, and eight existing federal programs are outlined that support (1) public library services, (2) interlibrary cooperation, (3) school libraries…

Cataloging Before and After OCLC. Illinois Valley Library System OCLC Experimental Project. Report No. 3.

ERIC Educational Resources Information Center

Bills, Linda G.

A project was conducted from 1980 to 1982 to determine the costs and benefits of OCLC use in 29 small and medium-sized member libraries of the Illinois Valley Library System (IVLS). Academic, school, public, and special libraries participated by recording the time and staffing levels used for and the cost of OCLC and pre-OCLC cataloging (by…

MCBooster: a library for fast Monte Carlo generation of phase-space decays on massively parallel platforms.

NASA Astrophysics Data System (ADS)

Alves Júnior, A. A.; Sokoloff, M. D.

2017-10-01

MCBooster is a header-only, C++11-compliant library that provides routines to generate and perform calculations on large samples of phase space Monte Carlo events. To achieve superior performance, MCBooster is capable to perform most of its calculations in parallel using CUDA- and OpenMP-enabled devices. MCBooster is built on top of the Thrust library and runs on Linux systems. This contribution summarizes the main features of MCBooster. A basic description of the user interface and some examples of applications are provided, along with measurements of performance in a variety of environments

A platform for rapid prototyping of synthetic gene networks in mammalian cells

PubMed Central

Duportet, Xavier; Wroblewska, Liliana; Guye, Patrick; Li, Yinqing; Eyquem, Justin; Rieders, Julianne; Rimchala, Tharathorn; Batt, Gregory; Weiss, Ron

2014-01-01

Mammalian synthetic biology may provide novel therapeutic strategies, help decipher new paths for drug discovery and facilitate synthesis of valuable molecules. Yet, our capacity to genetically program cells is currently hampered by the lack of efficient approaches to streamline the design, construction and screening of synthetic gene networks. To address this problem, here we present a framework for modular and combinatorial assembly of functional (multi)gene expression vectors and their efficient and specific targeted integration into a well-defined chromosomal context in mammalian cells. We demonstrate the potential of this framework by assembling and integrating different functional mammalian regulatory networks including the largest gene circuit built and chromosomally integrated to date (6 transcription units, 27kb) encoding an inducible memory device. Using a library of 18 different circuits as a proof of concept, we also demonstrate that our method enables one-pot/single-flask chromosomal integration and screening of circuit libraries. This rapid and powerful prototyping platform is well suited for comparative studies of genetic regulatory elements, genes and multi-gene circuits as well as facile development of libraries of isogenic engineered cell lines. PMID:25378321

n-CoDeR concept: unique types of antibodies for diagnostic use and therapy.

PubMed

Carlsson, R; Söderlind, E

2001-05-01

The n-CoDeR recombinant antibody gene libraries are built on a single master framework, into which diverse in vivo-formed complementarity determining regions (CDRs) are allowed to recombine. These CDRs are sampled from in vivo-processed and proof-read gene sequences, thus ensuring an optimal level of correctly folded and functional molecules. By the modularized assembly process, up to six CDRs can be varied at the same time, providing a possibility for the creation of a hitherto undescribed genetic and functional variation. The n-CoDeR antibody gene libraries can be used to select highly specific, human antibody fragments with specificities to virtually any antigen, including carbohydrates and human self-proteins and with affinities down into the subnanomolar range. Furthermore, combining CDRs sampled from in vivo-processed sequences into a single framework result in molecules exhibiting a lower immunogenicity compared to normal human immunoglobulins, as determined by computer analyses. The distinguished features of the n-CoDeR libraries in the therapeutic and diagnostic areas are discussed.

CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening.

PubMed

Köferle, Anna; Worf, Karolina; Breunig, Christopher; Baumann, Valentin; Herrero, Javier; Wiesbeck, Maximilian; Hutter, Lukas H; Götz, Magdalena; Fuchs, Christiane; Beck, Stephan; Stricker, Stefan H

2016-11-14

The bacterial CRISPR system is fast becoming the most popular genetic and epigenetic engineering tool due to its universal applicability and adaptability. The desire to deploy CRISPR-based methods in a large variety of species and contexts has created an urgent need for the development of easy, time- and cost-effective methods enabling large-scale screening approaches. Here we describe CORALINA (comprehensive gRNA library generation through controlled nuclease activity), a method for the generation of comprehensive gRNA libraries for CRISPR-based screens. CORALINA gRNA libraries can be derived from any source of DNA without the need of complex oligonucleotide synthesis. We show the utility of CORALINA for human and mouse genomic DNA, its reproducibility in covering the most relevant genomic features including regulatory, coding and non-coding sequences and confirm the functionality of CORALINA generated gRNAs. The simplicity and cost-effectiveness make CORALINA suitable for any experimental system. The unprecedented sequence complexities obtainable with CORALINA libraries are a necessary pre-requisite for less biased large scale genomic and epigenomic screens.

Draco,Version 6.x.x

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Kelly; Budge, Kent; Lowrie, Rob

2016-03-03

Draco is an object-oriented component library geared towards numerically intensive, radiation (particle) transport applications built for parallel computing hardware. It consists of semi-independent packages and a robust build system. The packages in Draco provide a set of components that can be used by multiple clients to build transport codes. The build system can also be extracted for use in clients. Software includes smart pointers, Design-by-Contract assertions, unit test framework, wrapped MPI functions, a file parser, unstructured mesh data structures, a random number generator, root finders and an angular quadrature component.

Automated software development workstation

NASA Technical Reports Server (NTRS)

1986-01-01

Engineering software development was automated using an expert system (rule-based) approach. The use of this technology offers benefits not available from current software development and maintenance methodologies. A workstation was built with a library or program data base with methods for browsing the designs stored; a system for graphical specification of designs including a capability for hierarchical refinement and definition in a graphical design system; and an automated code generation capability in FORTRAN. The workstation was then used in a demonstration with examples from an attitude control subsystem design for the space station. Documentation and recommendations are presented.

Mould routine identification in the clinical laboratory by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

PubMed

Cassagne, Carole; Ranque, Stéphane; Normand, Anne-Cécile; Fourquet, Patrick; Thiebault, Sandrine; Planard, Chantal; Hendrickx, Marijke; Piarroux, Renaud

2011-01-01

MALDI-TOF MS recently emerged as a valuable identification tool for bacteria and yeasts and revolutionized the daily clinical laboratory routine. But it has not been established for routine mould identification. This study aimed to validate a standardized procedure for MALDI-TOF MS-based mould identification in clinical laboratory. First, pre-extraction and extraction procedures were optimized. With this standardized procedure, a 143 mould strains reference spectra library was built. Then, the mould isolates cultured from sequential clinical samples were prospectively subjected to this MALDI-TOF MS based-identification assay. MALDI-TOF MS-based identification was considered correct if it was concordant with the phenotypic identification; otherwise, the gold standard was DNA sequence comparison-based identification. The optimized procedure comprised a culture on sabouraud-gentamicin-chloramphenicol agar followed by a chemical extraction of the fungal colonies with formic acid and acetonitril. The identification was done using a reference database built with references from at least four culture replicates. For five months, 197 clinical isolates were analyzed; 20 were excluded because they were not identified at the species level. MALDI-TOF MS-based approach correctly identified 87% (154/177) of the isolates analyzed in a routine clinical laboratory activity. It failed in 12% (21/177), whose species were not represented in the reference library. MALDI-TOF MS-based identification was correct in 154 out of the remaining 156 isolates. One Beauveria bassiana was not identified and one Rhizopus oryzae was misidentified as Mucor circinelloides. This work's seminal finding is that a standardized procedure can also be used for MALDI-TOF MS-based identification of a wide array of clinically relevant mould species. It thus makes it possible to identify moulds in the routine clinical laboratory setting and opens new avenues for the development of an integrated MALDI-TOF MS-based solution for the identification of any clinically relevant microorganism.

Comparing viral metagenomics methods using a highly multiplexed human viral pathogens reagent

PubMed Central

Li, Linlin; Deng, Xutao; Mee, Edward T.; Collot-Teixeira, Sophie; Anderson, Rob; Schepelmann, Silke; Minor, Philip D.; Delwart, Eric

2014-01-01

Unbiased metagenomic sequencing holds significant potential as a diagnostic tool for the simultaneous detection of any previously genetically described viral nucleic acids in clinical samples. Viral genome sequences can also inform on likely phenotypes including drug susceptibility or neutralization serotypes. In this study, different variables of the laboratory methods often used to generate viral metagenomics libraries on the efficiency of viral detection and virus genome coverage were compared. A biological reagent consisting of 25 different human RNA and DNA viral pathogens was used to estimate the effect of filtration and nuclease digestion, DNA/RNA extraction methods, pre-amplification and the use of different library preparation kits on the detection of viral nucleic acids. Filtration and nuclease treatment led to slight decreases in the percentage of viral sequence reads and number of viruses detected. For nucleic acid extractions silica spin columns improved viral sequence recovery relative to magnetic beads and Trizol extraction. Pre-amplification using random RT-PCR while generating more viral sequence reads resulted in detection of fewer viruses, more overlapping sequences, and lower genome coverage. The ScriptSeq library preparation method retrieved more viruses and a greater fraction of their genomes than the TruSeq and Nextera methods. Viral metagenomics sequencing was able to simultaneously detect up to 22 different viruses in the biological reagent analyzed including all those detected by qPCR. Further optimization will be required for the detection of viruses in biologically more complex samples such as tissues, blood, or feces. PMID:25497414

Molecular association of pathogenetic contributors to pre-eclampsia (pre-eclampsia associome)

PubMed Central

2015-01-01

Background Pre-eclampsia is the most common complication occurring during pregnancy. In the majority of cases, it is concurrent with other pathologies in a comorbid manner (frequent co-occurrences in patients), such as diabetes mellitus, gestational diabetes and obesity. Providing bronchial asthma, pulmonary tuberculosis, certain neurodegenerative diseases and cancers as examples, we have shown previously that pairs of inversely comorbid pathologies (rare co-occurrences in patients) are more closely related to each other at the molecular genetic level compared with randomly generated pairs of diseases. Data in the literature concerning the causes of pre-eclampsia are abundant. However, the key mechanisms triggering this disease that are initiated by other pathological processes are thus far unknown. The aim of this work was to analyse the characteristic features of genetic networks that describe interactions between comorbid diseases, using pre-eclampsia as a case in point. Results The use of ANDSystem, Pathway Studio and STRING computer tools based on text-mining and database-mining approaches allowed us to reconstruct associative networks, representing molecular genetic interactions between genes, associated concurrently with comorbid disease pairs, including pre-eclampsia, diabetes mellitus, gestational diabetes and obesity. It was found that these associative networks statistically differed in the number of genes and interactions between them from those built for randomly chosen pairs of diseases. The associative network connecting all four diseases was composed of 16 genes (PLAT, ADIPOQ, ADRB3, LEPR, HP, TGFB1, TNFA, INS, CRP, CSRP1, IGFBP1, MBL2, ACE, ESR1, SHBG, ADA). Such an analysis allowed us to reveal differential gene risk factors for these diseases, and to propose certain, most probable, theoretical mechanisms of pre-eclampsia development in pregnant women. The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-eclampsia]; [TNFA or INS]-[NOS3]-[pre-eclampsia]; [INS]-[HSPA4 or CLU]-[pre-eclampsia]; [ACE]-[MTHFR]-[pre-eclampsia]. Conclusions For pre-eclampsia, diabetes mellitus, gestational diabetes and obesity, we showed that the size and connectivity of the associative molecular genetic networks, which describe interactions between comorbid diseases, statistically exceeded the size and connectivity of those built for randomly chosen pairs of diseases. Recently, we have shown a similar result for inversely comorbid diseases. This suggests that comorbid and inversely comorbid diseases have common features concerning structural organization of associative molecular genetic networks. PMID:25879409

Use of Audiobooks in a School Library and Positive Effects of Struggling Readers' Participation in a Library-Sponsored Audiobook Club

ERIC Educational Resources Information Center

Whittingham, Jeff; Huffman, Stephanie; Christensen, Rob; McAllister, Tracy

2013-01-01

A study was conducted to determine the impact of the use of audiobooks with struggling readers in a school library audiobook club. The participants met weekly in the school library with the school librarian and researchers to discuss audiobooks and make reading recommendations to their peers. Standardized test data as well as pre- and post-study…

Aerospace Toolbox--a flight vehicle design, analysis, simulation, and software development environment II: an in-depth overview

NASA Astrophysics Data System (ADS)

Christian, Paul M.

2002-07-01

This paper presents a demonstrated approach to significantly reduce the cost and schedule of non real-time modeling and simulation, real-time HWIL simulation, and embedded code development. The tool and the methodology presented capitalize on a paradigm that has become a standard operating procedure in the automotive industry. The tool described is known as the Aerospace Toolbox, and it is based on the MathWorks Matlab/Simulink framework, which is a COTS application. Extrapolation of automotive industry data and initial applications in the aerospace industry show that the use of the Aerospace Toolbox can make significant contributions in the quest by NASA and other government agencies to meet aggressive cost reduction goals in development programs. The part I of this paper provided a detailed description of the GUI based Aerospace Toolbox and how it is used in every step of a development program; from quick prototyping of concept developments that leverage built-in point of departure simulations through to detailed design, analysis, and testing. Some of the attributes addressed included its versatility in modeling 3 to 6 degrees of freedom, its library of flight test validated library of models (including physics, environments, hardware, and error sources), and its built-in Monte Carlo capability. Other topics that were covered in part I included flight vehicle models and algorithms, and the covariance analysis package, Navigation System Covariance Analysis Tools (NavSCAT). Part II of this series will cover a more in-depth look at the analysis and simulation capability and provide an update on the toolbox enhancements. It will also address how the Toolbox can be used as a design hub for Internet based collaborative engineering tools such as NASA's Intelligent Synthesis Environment (ISE) and Lockheed Martin's Interactive Missile Design Environment (IMD).

The effectiveness of interventions to increase physical activity among young girls: a meta-analysis.

PubMed

Biddle, Stuart J H; Braithwaite, Rock; Pearson, Natalie

2014-05-01

Pre-adolescent girls are an important target population for physical activity behaviour change as it may enhance tracking into the crucial period of adolescence. The quantification of intervention effectiveness for this age group of girls has not been previously reported. Studies published in English up to and including August 2013 were located from computerised (MedLine, PsychInfo, Science Direct, Web of Science, EPPI centre databases, and Cochrane Library database) and manual searches. Intervention studies aimed at promoting physical activity, which included pre-adolescent girls aged 5-11 years, and a non-physical activity control/comparison group were included. A random effects meta-analysis was conducted. The average treatment effect for pre-adolescent girls involved in physical activity interventions was significant but small (g=0.314, p<.001). Moderator analyses showed larger effects for interventions that catered for girls only and used educational and multicomponent strategies. Interventions to increase physical activity in pre-adolescent girls show small but significant effects, suggesting that behaviour change may be challenging, but results suggest some strategies that could be successful. Copyright © 2014 Elsevier Inc. All rights reserved.

Expanded serial communication capability for the transport systems research vehicle laptop computers

NASA Technical Reports Server (NTRS)

Easley, Wesley C.

1991-01-01

A recent upgrade of the Transport Systems Research Vehicle (TSRV) operated by the Advanced Transport Operating Systems Program Office at the NASA Langley Research Center included installation of a number of Grid 1500 series laptop computers. Each unit is a 80386-based IBM PC clone. RS-232 data busses are needed for TSRV flight research programs, and it has been advantageous to extend the application of the Grids in this area. Use was made of the expansion features of the Grid internal bus to add a user programmable serial communication channel. Software to allow use of the Grid bus expansion has been written and placed in a Turbo C library for incorporation into applications programs in a transparent manner via function calls. Port setup; interrupt-driven, two-way data transfer; and software flow control are built into the library functions.

Interplanetary Overlay Network Bundle Protocol Implementation

NASA Technical Reports Server (NTRS)

Burleigh, Scott C.

2011-01-01

The Interplanetary Overlay Network (ION) system's BP package, an implementation of the Delay-Tolerant Networking (DTN) Bundle Protocol (BP) and supporting services, has been specifically designed to be suitable for use on deep-space robotic vehicles. Although the ION BP implementation is unique in its use of zero-copy objects for high performance, and in its use of resource-sensitive rate control, it is fully interoperable with other implementations of the BP specification (Internet RFC 5050). The ION BP implementation is built using the same software infrastructure that underlies the implementation of the CCSDS (Consultative Committee for Space Data Systems) File Delivery Protocol (CFDP) built into the flight software of Deep Impact. It is designed to minimize resource consumption, while maximizing operational robustness. For example, no dynamic allocation of system memory is required. Like all the other ION packages, ION's BP implementation is designed to port readily between Linux and Solaris (for easy development and for ground system operations) and VxWorks (for flight systems operations). The exact same source code is exercised in both environments. Initially included in the ION BP implementations are the following: libraries of functions used in constructing bundle forwarders and convergence-layer (CL) input and output adapters; a simple prototype bundle forwarder and associated CL adapters designed to run over an IPbased local area network; administrative tools for managing a simple DTN infrastructure built from these components; a background daemon process that silently destroys bundles whose time-to-live intervals have expired; a library of functions exposed to applications, enabling them to issue and receive data encapsulated in DTN bundles; and some simple applications that can be used for system checkout and benchmarking.

Building a Digital Library from the Ground Up: an Examination of Emergent Information Resources in the Machine Learning Community

NASA Astrophysics Data System (ADS)

Cunningham, Sally Jo

The current crop of digital libraries for the computing community are strongly grounded in the conventional library paradigm: they provide indexes to support searching of collections of research papers. As such, these digital libraries are relatively impoverished; the present computing digital libraries omit many of the documents and resources that are currently available to computing researchers, and offer few browsing structures. These computing digital libraries were built 'top down': the resources and collection contents are forced to fit an existing digital library architecture. A 'bottom up' approach to digital library development would begin with an investigation of a community's information needs and available documents, and then design a library to organize those documents in such a way as to fulfill the community's needs. The 'home grown', informal information resources developed by and for the machine learning community are examined as a case study, to determine the types of information and document organizations 'native' to this group of researchers. The insights gained in this type of case study can be used to inform construction of a digital library tailored to this community.

Health sciences libraries building survey, 1999-2009.

PubMed

Ludwig, Logan

2010-04-01

A survey was conducted of health sciences libraries to obtain information about newer buildings, additions, remodeling, and renovations. An online survey was developed, and announcements of survey availability posted to three major email discussion lists: Medical Library Association (MLA), Association of Academic Health Sciences Libraries (AAHSL), and MEDLIB-L. Previous discussions of library building projects on email discussion lists, a literature review, personal communications, and the author's consulting experiences identified additional projects. Seventy-eight health sciences library building projects at seventy-three institutions are reported. Twenty-two are newer facilities built within the last ten years; two are space expansions; forty-five are renovation projects; and nine are combinations of new and renovated space. Six institutions report multiple or ongoing renovation projects during the last ten years. The survey results confirm a continuing migration from print-based to digitally based collections and reveal trends in library space design. Some health sciences libraries report loss of space as they move toward creating space for "community" building. Libraries are becoming more proactive in using or retooling space for concentration, collaboration, contemplation, communication, and socialization. All are moving toward a clearer operational vision of the library as the institution's information nexus and not merely as a physical location with print collections.

Chimenea and other tools: Automated imaging of multi-epoch radio-synthesis data with CASA

NASA Astrophysics Data System (ADS)

Staley, T. D.; Anderson, G. E.

2015-11-01

In preparing the way for the Square Kilometre Array and its pathfinders, there is a pressing need to begin probing the transient sky in a fully robotic fashion using the current generation of radio telescopes. Effective exploitation of such surveys requires a largely automated data-reduction process. This paper introduces an end-to-end automated reduction pipeline, AMIsurvey, used for calibrating and imaging data from the Arcminute Microkelvin Imager Large Array. AMIsurvey makes use of several component libraries which have been packaged separately for open-source release. The most scientifically significant of these is chimenea, which implements a telescope-agnostic algorithm for automated imaging of pre-calibrated multi-epoch radio-synthesis data, of the sort typically acquired for transient surveys or follow-up. The algorithm aims to improve upon standard imaging pipelines by utilizing iterative RMS-estimation and automated source-detection to avoid so called 'Clean-bias', and makes use of CASA subroutines for the underlying image-synthesis operations. At a lower level, AMIsurvey relies upon two libraries, drive-ami and drive-casa, built to allow use of mature radio-astronomy software packages from within Python scripts. While targeted at automated imaging, the drive-casa interface can also be used to automate interaction with any of the CASA subroutines from a generic Python process. Additionally, these packages may be of wider technical interest beyond radio-astronomy, since they demonstrate use of the Python library pexpect to emulate terminal interaction with an external process. This approach allows for rapid development of a Python interface to any legacy or externally-maintained pipeline which accepts command-line input, without requiring alterations to the original code.

INSPECT: A graphical user interface software package for IDARC-2D

NASA Astrophysics Data System (ADS)

AlHamaydeh, Mohammad; Najib, Mohamad; Alawnah, Sameer

Modern day Performance-Based Earthquake Engineering (PBEE) pivots about nonlinear analysis and its feasibility. IDARC-2D is a widely used and accepted software for nonlinear analysis; it possesses many attractive features and capabilities. However, it is operated from the command prompt in the DOS/Unix systems and requires elaborate text-based input files creation by the user. To complement and facilitate the use of IDARC-2D, a pre-processing GUI software package (INSPECT) is introduced herein. INSPECT is created in the C# environment and utilizes the .NET libraries and SQLite database. Extensive testing and verification demonstrated successful and high-fidelity re-creation of several existing IDARC-2D input files. Its design and built-in features aim at expediting, simplifying and assisting in the modeling process. Moreover, this practical aid enhances the reliability of the results and improves accuracy by reducing and/or eliminating many potential and common input mistakes. Such benefits would be appreciated by novice and veteran IDARC-2D users alike.

A Study of How We Study: Methodologies of School Library Research 2007 through July 2015

ERIC Educational Resources Information Center

Morris, Rebecca J.; Cahill, Maria

2017-01-01

In this study we investigated the research designs employed to study the interdisciplinary profession of school librarianship during a time period of notable changes across both the Pre-K-12 and school library domains. To conduct this work, we analyzed all 217 articles published in "School Library Research" (SLR) and "School…

Functional Repertoire of Antibiotic Resistance Genes in Antibiotic Manufacturing Effluents and Receiving Freshwater Sediments

PubMed Central

González-Plaza, Juan J.; Šimatović, Ana; Milaković, Milena; Bielen, Ana; Wichmann, Fabienne; Udiković-Kolić, Nikolina

2018-01-01

Environments polluted by direct discharges of effluents from antibiotic manufacturing are important reservoirs for antibiotic resistance genes (ARGs), which could potentially be transferred to human pathogens. However, our knowledge about the identity and diversity of ARGs in such polluted environments remains limited. We applied functional metagenomics to explore the resistome of two Croatian antibiotic manufacturing effluents and sediments collected upstream of and at the effluent discharge sites. Metagenomic libraries built from an azithromycin-production site were screened for resistance to macrolide antibiotics, whereas the libraries from a site producing veterinary antibiotics were screened for resistance to sulfonamides, tetracyclines, trimethoprim, and beta-lactams. Functional analysis of eight libraries identified a total of 82 unique, often clinically relevant ARGs, which were frequently found in clusters and flanked by mobile genetic elements. The majority of macrolide resistance genes identified from matrices exposed to high levels of macrolides were similar to known genes encoding ribosomal protection proteins, macrolide phosphotransferases, and transporters. Potentially novel macrolide resistance genes included one most similar to a 23S rRNA methyltransferase from Clostridium and another, derived from upstream unpolluted sediment, to a GTPase HflX from Emergencia. In libraries deriving from sediments exposed to lower levels of veterinary antibiotics, we found 8 potentially novel ARGs, including dihydrofolate reductases and beta-lactamases from classes A, B, and D. In addition, we detected 7 potentially novel ARGs in upstream sediment, including thymidylate synthases, dihydrofolate reductases, and class D beta-lactamase. Taken together, in addition to finding known gene types, we report the discovery of novel and diverse ARGs in antibiotic-polluted industrial effluents and sediments, providing a qualitative basis for monitoring the dispersal of ARGs from environmental hotspots such as discharge sites of pharmaceutical effluents. PMID:29387045

Linking Formal and Informal Science Education: A Successful Model using Libraries, Volunteers and NASA Resources

NASA Astrophysics Data System (ADS)

Race, M. S.; Lafayette Library; Learning Center Foundation (Lllcf)

2011-12-01

In these times of budget cuts, tight school schedules, and limited opportunities for student field trips and teacher professional development, it is especially difficult to expose elementary and middle school students to the latest STEM information-particularly in the space sciences. Using our library as a facilitator and catalyst, we built a volunteer-based, multi-faceted, curriculum-linked program for students and teachers in local middle schools (Grade 8) and showcased new astronomical and planetary science information using mainly NASA resources and volunteer effort. The project began with the idea of bringing free NASA photo exhibits (FETTU) to the Lafayette and Antioch Libraries for public display. Subsequently, the effort expanded by adding layers of activities that brought space and science information to teachers, students and the pubic at 5 libraries and schools in the 2 cities, one of which serves a diverse, underserved community. Overall, the effort (supported by a pilot grant from the Bechtel Foundation) included school and library based teacher workshops with resource materials; travelling space museum visits with hands-on activities (Chabot-to-Go); separate powerpoint presentations for students and adults at the library; and concurrent ancillary space-related themes for young children's programs at the library. This pilot project, based largely on the use of free government resources and online materials, demonstrated that volunteer-based, standards-linked STEM efforts can enhance curriculum at the middle school, with libraries serving a special role. Using this model, we subsequently also obtained a small NASA-Space Grant award to bring star parties and hand-on science activities to three libraries this Fall, linking with numerous Grade 5 teachers and students in two additional underserved areas of our county. It's not necessary to reinvent the wheel, you just collect the pieces and build on what you already have.

Renovated, repurposed, and still "one sweet library": a case study on loss of space from the Health Sciences and Human Services Library, University of Maryland, Baltimore.

PubMed

Tooey, Mary Joan M J

2010-01-01

The Health Sciences and Human Services Library (HS/HSL), University of Maryland, Baltimore (UMB), is located in an urban environment on the west side of downtown Baltimore. Founded in 1813, the library opened its current building in 1998 and is one of the largest health sciences libraries in the United States, with 6 floors and over 180,000 gross square and 118,000 net assignable square feet (NASF). The initial discussions in late 2005 involved moving campus offices into the library. Almost immediately, it was recognized that a much larger renovation was needed due to the scope of the work. The vice president for academic affairs, the library executive director, and campus planners agreed that if the renovation was done thoughtfully, multiple needs could be met, including new office spaces, better user spaces, and synergy with the new campus center being built next door. The planning, design, and construction process was multifaceted and on a fast track. Although the final piece of the renovation was completed in June 2009, the majority of the planning, design, and construction took place between March 2006 and June 2008. All tenants were involved with office design. Library staff were involved in designing the public spaces and planning the strategy for weeding and shifting. Approximately 8,000 NASF was reallocated to new office space from shelving space, amounting to approximately 6.7% of the building NASF and approximately 10.6% of the public space in the building. The majority of new offices in the building report to the same vice president and are student focused and service oriented, with similar missions to that of the library resulting in a very harmonious cohabitation. Additional units with these missions and reporting structure are located in the new campus center, creating a synergy between the two buildings.

Comprehensive peptidomimetic libraries targeting protein-protein interactions.

PubMed

Whitby, Landon R; Boger, Dale L

2012-10-16

Transient protein-protein interactions (PPIs) are essential components in cellular signaling pathways as well as in important processes such as viral infection, replication, and immune suppression. The unknown or uncharacterized PPIs involved in such interaction networks often represent compelling therapeutic targets for drug discovery. To date, however, the main strategies for discovery of small molecule modulators of PPIs are typically limited to structurally characterized targets. Recent developments in molecular scaffolds that mimic the side chain display of peptide secondary structures have yielded effective designs, but few screening libraries of such mimetics are available to interrogate PPI targets. We initiated a program to prepare a comprehensive small molecule library designed to mimic the three major recognition motifs that mediate PPIs (α-helix, β-turn, and β-strand). Three libraries would be built around templates designed to mimic each such secondary structure and substituted with all triplet combinations of groups representing the 20 natural amino acid side chains. When combined, the three libraries would contain a member capable of mimicking the key interaction and recognition residues of most targetable PPIs. In this Account, we summarize the results of the design, synthesis, and validation of an 8000 member α-helix mimetic library and a 4200 member β-turn mimetic library. We expect that the screening of these libraries will not only provide lead structures against α-helix- or β-turn-mediated protein-protein or peptide-receptor interactions, even if the nature of the interaction is unknown, but also yield key insights into the recognition motif (α-helix or β-turn) and identify the key residues mediating the interaction. Consistent with this expectation, the screening of the libraries against p53/MDM2 and HIV-1 gp41 (α-helix mimetic library) or the opioid receptors (β-turn mimetic library) led to the discovery of library members expected to mimic the known endogenous ligands. These efforts led to the discovery of high-affinity α-helix mimetics (K(i) = 0.7 μM) against HIV-1 gp41 as well as high-affinity and selective β-turn mimetics (K(i) = 80 nM) against the κ-opioid receptor. The results suggest that the use of such comprehensive libraries of peptide secondary structure mimetics, built around effective molecular scaffolds, constitutes a powerful method of interrogating PPIs. These structures provide small molecule modulators of PPI networks for therapeutic target validation, lead compound discovery, and the identification of modulators of biological processes for further study.

Megasite Management Tool (mmt): a Decision Support System Built Using Mapwindow Activex Control

NASA Astrophysics Data System (ADS)

Pulsani, B. R.

2017-11-01

Megasite Management Tool (MMT) is planning and evaluation software for contaminated sites. Using different statistical modules, MMT produces maps which help decision makers in rehabilitating contaminated sites. The input data used by MMT is of geographic nature and exists as shapefile and raster format. As MMT is built using simple windows forms application, the objective of the study was to find a way to visualize geographic data and to allow the user to edit its attribute information. Therefore, the application requirement was to find GIS libraries which offer capabilities such as (1) map viewer with navigation tools (2) library to read/write geographic data and (3) software which allows free distribution of the developed components. A research on these requirements led to the discovery of MapWindow ActiveX components which not only offered these capabilities but also provided free and open source licensing options for redistribution. Although considerable amount of reports and publications exist on MMT, the major contribution provided by MapWindow libraries have been under played. The current study emphasises upon the contribution and advantages MapWindow ActiveX provides for incorporating GIS functionality to an already existing application. Similar components for other languages have also been reviewed.

Library Literacy Project, 1987-88. Pottsville, Pennsylvania, Free Public Library.

ERIC Educational Resources Information Center

Smink, Nancy J.

This project was undertaken by a public library to assess and address the continuing literacy needs of the local county's population. Comparison of the results of pre- and post-grant surveys conducted to determine the level of the residents' awareness of the problems of illiteracy showed an increase from 60% to 81% in the number who knew about the…

Health Libraries and Information Services in Tanzania: A Strategic Assessment

PubMed Central

Haruna, Hussein; Mtoroki, Majaliwa; Gerendasy, Dan D.; Detlefsen, Ellen G.

2016-01-01

Objective To identify the current status and local impact of health sciences libraries and the perception of these libraries by their users, as a pre-requisite to the development of a competence-based curriculum for health information science training in Tanzania. Methodology A needs assessment was carried out using a convenience sample of local respondents, including librarians, trainers, academicians, students, health care providers and patients and families, drawn from national, referral, regional, district hospitals, health training institutions, and Universities from both government and non-government entities in Tanzania. A focus group approach was used to gather data from respondents. Results Results from this assessment revealed that health science libraries in Tanzania are faced with the challenges of insufficient infrastructure, old technology, limited facilities and furniture, inadequate and incompetent library staff, lack of health sciences librarians, outdated and insufficient resources, as well as low knowledge and use of information technologies by library clients. Most respondents would prefer to have both physical and electronic libraries, as well as librarians with specialized health information science skills, to cope with changing nature of the medical field. Conclusion The findings obtained from this assessment are strong enough to guide the development of a curriculum and training strategy and an operational plan and training packages for health information professionals. The development of a training curriculum for health information science professionals will mean better health information service delivery for Tanzania. PMID:28283146

Sigma Periodic Table Browse

Science.gov Websites

library. • Fission yields. • Pre-calculated integral quantities. • Improved zooming. New in version 3.0 , ENDF/B-VI.8 libraries. • Neutron cross section distributions (MF=3). • Experimental data in EXFOR

Template-based combinatorial enumeration of virtual compound libraries for lipids

PubMed Central

2012-01-01

A variety of software packages are available for the combinatorial enumeration of virtual libraries for small molecules, starting from specifications of core scaffolds with attachments points and lists of R-groups as SMILES or SD files. Although SD files include atomic coordinates for core scaffolds and R-groups, it is not possible to control 2-dimensional (2D) layout of the enumerated structures generated for virtual compound libraries because different packages generate different 2D representations for the same structure. We have developed a software package called LipidMapsTools for the template-based combinatorial enumeration of virtual compound libraries for lipids. Virtual libraries are enumerated for the specified lipid abbreviations using matching lists of pre-defined templates and chain abbreviations, instead of core scaffolds and lists of R-groups provided by the user. 2D structures of the enumerated lipids are drawn in a specific and consistent fashion adhering to the framework for representing lipid structures proposed by the LIPID MAPS consortium. LipidMapsTools is lightweight, relatively fast and contains no external dependencies. It is an open source package and freely available under the terms of the modified BSD license. PMID:23006594

Template-based combinatorial enumeration of virtual compound libraries for lipids.

PubMed

Sud, Manish; Fahy, Eoin; Subramaniam, Shankar

2012-09-25

A variety of software packages are available for the combinatorial enumeration of virtual libraries for small molecules, starting from specifications of core scaffolds with attachments points and lists of R-groups as SMILES or SD files. Although SD files include atomic coordinates for core scaffolds and R-groups, it is not possible to control 2-dimensional (2D) layout of the enumerated structures generated for virtual compound libraries because different packages generate different 2D representations for the same structure. We have developed a software package called LipidMapsTools for the template-based combinatorial enumeration of virtual compound libraries for lipids. Virtual libraries are enumerated for the specified lipid abbreviations using matching lists of pre-defined templates and chain abbreviations, instead of core scaffolds and lists of R-groups provided by the user. 2D structures of the enumerated lipids are drawn in a specific and consistent fashion adhering to the framework for representing lipid structures proposed by the LIPID MAPS consortium. LipidMapsTools is lightweight, relatively fast and contains no external dependencies. It is an open source package and freely available under the terms of the modified BSD license.

Sequencing analysis of 20,000 full-length cDNA clones from cassava reveals lineage specific expansions in gene families related to stress response

PubMed Central

Sakurai, Tetsuya; Plata, Germán; Rodríguez-Zapata, Fausto; Seki, Motoaki; Salcedo, Andrés; Toyoda, Atsushi; Ishiwata, Atsushi; Tohme, Joe; Sakaki, Yoshiyuki; Shinozaki, Kazuo; Ishitani, Manabu

2007-01-01

Background Cassava, an allotetraploid known for its remarkable tolerance to abiotic stresses is an important source of energy for humans and animals and a raw material for many industrial processes. A full-length cDNA library of cassava plants under normal, heat, drought, aluminum and post harvest physiological deterioration conditions was built; 19968 clones were sequence-characterized using expressed sequence tags (ESTs). Results The ESTs were assembled into 6355 contigs and 9026 singletons that were further grouped into 10577 scaffolds; we found 4621 new cassava sequences and 1521 sequences with no significant similarity to plant protein databases. Transcripts of 7796 distinct genes were captured and we were able to assign a functional classification to 78% of them while finding more than half of the enzymes annotated in metabolic pathways in Arabidopsis. The annotation of sequences that were not paired to transcripts of other species included many stress-related functional categories showing that our library is enriched with stress-induced genes. Finally, we detected 230 putative gene duplications that include key enzymes in reactive oxygen species signaling pathways and could play a role in cassava stress response features. Conclusion The cassava full-length cDNA library here presented contains transcripts of genes involved in stress response as well as genes important for different areas of cassava research. This library will be an important resource for gene discovery, characterization and cloning; in the near future it will aid the annotation of the cassava genome. PMID:18096061

Do Natural Experiments of Changes in Neighborhood Built Environment Impact Physical Activity and Diet? A Systematic Review

PubMed Central

George, Emma S.; Feng, Xiaoqi; Merom, Dafna; Bennie, Andrew; Cook, Amelia; Dwyer, Genevieve; Pang, Bonnie; Astell-Burt, Thomas

2018-01-01

Physical activity and diet are major modifiable risk factors for chronic disease and have been shown to be associated with neighborhood built environment. Systematic review evidence from longitudinal studies on the impact of changing the built environment on physical activity and diet is currently lacking. A systematic review of natural experiments of neighborhood built environment was conducted. The aims of this systematic review were to summarize study characteristics, study quality, and impact of changes in neighborhood built environment on physical activity and diet outcomes among residents. Natural experiments of neighborhood built environment change, exploring longitudinal impacts on physical activity and/or diet in residents, were included. From five electronic databases, 2084 references were identified. A narrative synthesis was conducted, considering results in relation to study quality. Nineteen papers, reporting on 15 different exposures met inclusion criteria. Four studies included a comparison group and 11 were pre-post/longitudinal studies without a comparison group. Studies reported on the impact of redeveloping or introducing cycle and/or walking trails (n = 5), rail stops/lines (n = 4), supermarkets and farmers’ markets (n = 4) and park and green space (n = 2). Eight/15 studies reported at least one beneficial change in physical activity, diet or another associated health outcome. Due to limitations in study design and reporting, as well as the wide array of outcome measures reported, drawing conclusions to inform policy was challenging. Future research should consider a consistent approach to measure the same outcomes (e.g., using measurement methods that collect comparable physical activity and diet outcome data), to allow for pooled analyses. Additionally, including comparison groups wherever possible and ensuring high quality reporting is essential. PMID:29373567

Do Natural Experiments of Changes in Neighborhood Built Environment Impact Physical Activity and Diet? A Systematic Review.

PubMed

MacMillan, Freya; George, Emma S; Feng, Xiaoqi; Merom, Dafna; Bennie, Andrew; Cook, Amelia; Sanders, Taren; Dwyer, Genevieve; Pang, Bonnie; Guagliano, Justin M; Kolt, Gregory S; Astell-Burt, Thomas

2018-01-26

Physical activity and diet are major modifiable risk factors for chronic disease and have been shown to be associated with neighborhood built environment. Systematic review evidence from longitudinal studies on the impact of changing the built environment on physical activity and diet is currently lacking. A systematic review of natural experiments of neighborhood built environment was conducted. The aims of this systematic review were to summarize study characteristics, study quality, and impact of changes in neighborhood built environment on physical activity and diet outcomes among residents. Natural experiments of neighborhood built environment change, exploring longitudinal impacts on physical activity and/or diet in residents, were included. From five electronic databases, 2084 references were identified. A narrative synthesis was conducted, considering results in relation to study quality. Nineteen papers, reporting on 15 different exposures met inclusion criteria. Four studies included a comparison group and 11 were pre-post/longitudinal studies without a comparison group. Studies reported on the impact of redeveloping or introducing cycle and/or walking trails ( n = 5), rail stops/lines ( n = 4), supermarkets and farmers' markets ( n = 4) and park and green space ( n = 2). Eight/15 studies reported at least one beneficial change in physical activity, diet or another associated health outcome. Due to limitations in study design and reporting, as well as the wide array of outcome measures reported, drawing conclusions to inform policy was challenging. Future research should consider a consistent approach to measure the same outcomes (e.g., using measurement methods that collect comparable physical activity and diet outcome data), to allow for pooled analyses. Additionally, including comparison groups wherever possible and ensuring high quality reporting is essential.

Why One-Shot Information Literacy Sessions Are Not the Future of Instruction: A Case for Online Credit Courses

ERIC Educational Resources Information Center

Mery,Yvonne; Newby, Jill; Peng, Ke

2012-01-01

This paper reports on a research project that examined the test scores of students who took part in an online information literacy course. Researchers analyzed the pre- and post-test scores of students who received different types of instruction including a traditional one-shot library session and an online course. Results show that students who…

Free oscilloscope web app using a computer mic, built-in sound library, or your own files

NASA Astrophysics Data System (ADS)

Ball, Edward; Ruiz, Frances; Ruiz, Michael J.

2017-07-01

We have developed an online oscilloscope program which allows users to see waveforms by utilizing their computer microphones, selecting from our library of over 30 audio files, and opening any *.mp3 or *.wav file on their computers. The oscilloscope displays real-time signals against time. The oscilloscope has been calibrated so one can make accurate frequency measurements of periodic waves to within 1%. The web app is ideal for computer projection in class.

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

PubMed

Horvath, Dragos; Lisurek, Michael; Rupp, Bernd; Kühne, Ronald; Specker, Edgar; von Kries, Jens; Rognan, Didier; Andersson, C David; Almqvist, Fredrik; Elofsson, Mikael; Enqvist, Per-Anders; Gustavsson, Anna-Lena; Remez, Nikita; Mestres, Jordi; Marcou, Gilles; Varnek, Alexander; Hibert, Marcel; Quintana, Jordi; Frank, Ronald

2014-10-01

This work describes a collaborative effort to define and apply a protocol for the rational selection of a general-purpose screening library, to be used by the screening platforms affiliated with the EU-OPENSCREEN initiative. It is designed as a standard source of compounds for primary screening against novel biological targets, at the request of research partners. Given the general nature of the potential applications of this compound collection, the focus of the selection strategy lies on ensuring chemical stability, absence of reactive compounds, screening-compliant physicochemical properties, loose compliance to drug-likeness criteria (as drug design is a major, but not exclusive application), and maximal diversity/coverage of chemical space, aimed at providing hits for a wide spectrum of drugable targets. Finally, practical availability/cost issues cannot be avoided. The main goal of this publication is to inform potential future users of this library about its conception, sources, and characteristics. The outline of the selection procedure, notably of the filtering rules designed by a large committee of European medicinal chemists and chemoinformaticians, may be of general methodological interest for the screening/medicinal chemistry community. The selection task of 200K molecules out of a pre-filtered set of 1.4M candidates was shared by five independent European research groups, each picking a subset of 40K compounds according to their own in-house methodology and expertise. An in-depth analysis of chemical space coverage of the library serves not only to characterize the collection, but also to compare the various chemoinformatics-driven selection procedures of maximal diversity sets. Compound selections contributed by various participating groups were mapped onto general-purpose self-organizing maps (SOMs) built on the basis of marketed drugs and bioactive reference molecules. In this way, the occupancy of chemical space by the EU-OPENSCREEN library could be directly compared with distributions of known bioactives of various classes. This mapping highlights the relevance of the selection and shows how the consensus reached by merging the five different 40K selections contributes to achieve this relevance. The approach also allows one to readily identify subsets of target- or target-class-oriented compounds from the EU-OPENSCREEN library to suit the needs of the diverse range of potential users. The final EU-OPENSCREEN library, assembled by merging five independent selections of 40K compounds from various expert groups, represents an excellent example of a Europe-wide collaborative effort toward the common objective of building best-in-class European open screening platforms. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Health sciences libraries building survey, 1999–2009

PubMed Central

Ludwig, Logan

2010-01-01

Objective: A survey was conducted of health sciences libraries to obtain information about newer buildings, additions, remodeling, and renovations. Method: An online survey was developed, and announcements of survey availability posted to three major email discussion lists: Medical Library Association (MLA), Association of Academic Health Sciences Libraries (AAHSL), and MEDLIB-L. Previous discussions of library building projects on email discussion lists, a literature review, personal communications, and the author's consulting experiences identified additional projects. Results: Seventy-eight health sciences library building projects at seventy-three institutions are reported. Twenty-two are newer facilities built within the last ten years; two are space expansions; forty-five are renovation projects; and nine are combinations of new and renovated space. Six institutions report multiple or ongoing renovation projects during the last ten years. Conclusions: The survey results confirm a continuing migration from print-based to digitally based collections and reveal trends in library space design. Some health sciences libraries report loss of space as they move toward creating space for “community” building. Libraries are becoming more proactive in using or retooling space for concentration, collaboration, contemplation, communication, and socialization. All are moving toward a clearer operational vision of the library as the institution's information nexus and not merely as a physical location with print collections. PMID:20428277

Software reuse example and challenges at NSIDC

NASA Astrophysics Data System (ADS)

Billingsley, B. W.; Brodzik, M.; Collins, J. A.

2009-12-01

NSIDC has created a new data discovery and access system, Searchlight, to provide users with the data they want in the format they want. NSIDC Searchlight supports discovery and access to disparate data types with on-the-fly reprojection, regridding and reformatting. Architected to both reuse open source systems and be reused itself, Searchlight reuses GDAL and Proj4 for manipulating data and format conversions, the netCDF Java library for creating netCDF output, MapServer and OpenLayers for defining spatial criteria and the JTS Topology Suite (JTS) in conjunction with Hibernate Spatial for database interaction and rich OGC-compliant spatial objects. The application reuses popular Java and Java Script libraries including Struts 2, Spring, JPA (Hibernate), Sitemesh, JFreeChart, JQuery, DOJO and a PostGIS PostgreSQL database. Future reuse of Searchlight components is supported at varying architecture levels, ranging from the database and model components to web services. We present the tools, libraries and programs that Searchlight has reused. We describe the architecture of Searchlight and explain the strategies deployed for reusing existing software and how Searchlight is built for reuse. We will discuss NSIDC reuse of the Searchlight components to support rapid development of new data delivery systems.

A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties

PubMed Central

Tiller, Thomas; Schuster, Ingrid; Deppe, Dorothée; Siegers, Katja; Strohner, Ralf; Herrmann, Tanja; Berenguer, Marion; Poujol, Dominique; Stehle, Jennifer; Stark, Yvonne; Heßling, Martin; Daubert, Daniela; Felderer, Karin; Kaden, Stefan; Kölln, Johanna; Enzelberger, Markus; Urlinger, Stefanie

2013-01-01

This report describes the design, generation and testing of Ylanthia, a fully synthetic human Fab antibody library with 1.3E+11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) variable heavy (VH)/variable light (VL) chain pairs, which cover a broad range of canonical complementarity-determining region (CDR) structures. The variable Ig heavy and Ig light (VH/VL) chain pairs were selected for biophysical characteristics favorable to manufacturing and development. The selection process included multiple parameters, e.g., assessment of protein expression yield, thermal stability and aggregation propensity in fragment antigen binding (Fab) and IgG1 formats, and relative Fab display rate on phage. The framework regions are fixed and the diversified CDRs were designed based on a systematic analysis of a large set of rearranged human antibody sequences. Care was taken to minimize the occurrence of potential posttranslational modification sites within the CDRs. Phage selection was performed against various antigens and unique antibodies with excellent biophysical properties were isolated. Our results confirm that quality can be built into an antibody library by prudent selection of unmodified, fully human VH/VL pairs as scaffolds. PMID:23571156

Open-Source Python Tools for Deploying Interactive GIS Dashboards for a Billion Datapoints on a Laptop

NASA Astrophysics Data System (ADS)

Steinberg, P. D.; Bednar, J. A.; Rudiger, P.; Stevens, J. L. R.; Ball, C. E.; Christensen, S. D.; Pothina, D.

2017-12-01

The rich variety of software libraries available in the Python scientific ecosystem provides a flexible and powerful alternative to traditional integrated GIS (geographic information system) programs. Each such library focuses on doing a certain set of general-purpose tasks well, and Python makes it relatively simple to glue the libraries together to solve a wide range of complex, open-ended problems in Earth science. However, choosing an appropriate set of libraries can be challenging, and it is difficult to predict how much "glue code" will be needed for any particular combination of libraries and tasks. Here we present a set of libraries that have been designed to work well together to build interactive analyses and visualizations of large geographic datasets, in standard web browsers. The resulting workflows run on ordinary laptops even for billions of data points, and easily scale up to larger compute clusters when available. The declarative top-level interface used in these libraries means that even complex, fully interactive applications can be built and deployed as web services using only a few dozen lines of code, making it simple to create and share custom interactive applications even for datasets too large for most traditional GIS systems. The libraries we will cover include GeoViews (HoloViews extended for geographic applications) for declaring visualizable/plottable objects, Bokeh for building visual web applications from GeoViews objects, Datashader for rendering arbitrarily large datasets faithfully as fixed-size images, Param for specifying user-modifiable parameters that model your domain, Xarray for computing with n-dimensional array data, Dask for flexibly dispatching computational tasks across processors, and Numba for compiling array-based Python code down to fast machine code. We will show how to use the resulting workflow with static datasets and with simulators such as GSSHA or AdH, allowing you to deploy flexible, high-performance web-based dashboards for your GIS data or simulations without needing major investments in code development or maintenance.

Renovated, repurposed, and still “one sweet library”: a case study on loss of space from the Health Sciences and Human Services Library, University of Maryland, Baltimore

PubMed Central

Tooey, Mary Joan (M.J.)

2010-01-01

Setting: The Health Sciences and Human Services Library (HS/HSL), University of Maryland, Baltimore (UMB), is located in an urban environment on the west side of downtown Baltimore. Founded in 1813, the library opened its current building in 1998 and is one of the largest health sciences libraries in the United States, with 6 floors and over 180,000 gross square and 118,000 net assignable square feet (NASF). Project: The initial discussions in late 2005 involved moving campus offices into the library. Almost immediately, it was recognized that a much larger renovation was needed due to the scope of the work. The vice president for academic affairs, the library executive director, and campus planners agreed that if the renovation was done thoughtfully, multiple needs could be met, including new office spaces, better user spaces, and synergy with the new campus center being built next door. Planning: The planning, design, and construction process was multifaceted and on a fast track. Although the final piece of the renovation was completed in June 2009, the majority of the planning, design, and construction took place between March 2006 and June 2008. All tenants were involved with office design. Library staff were involved in designing the public spaces and planning the strategy for weeding and shifting. Outcomes: Approximately 8,000 NASF was reallocated to new office space from shelving space, amounting to approximately 6.7% of the building NASF and approximately 10.6% of the public space in the building. The majority of new offices in the building report to the same vice president and are student focused and service oriented, with similar missions to that of the library resulting in a very harmonious cohabitation. Additional units with these missions and reporting structure are located in the new campus center, creating a synergy between the two buildings. PMID:20098653

Self Perceptions of Leadership Potential: A Study of Teacher-Leaders Educated to Be School Library Media Specialists Who Lead

ERIC Educational Resources Information Center

Smith, Daniella

2009-01-01

The purpose of this study was to determine the factors that impacted the level of self-perceived transformational leadership potential in pre-service school library media specialists who participated in a master's degree program in library and information studies focusing on leadership development. The participants of the study were a cohort of 30…

Jordanian Pre-Service Teachers' Perceptions of the Portfolio as a Reflective Learning Tool

ERIC Educational Resources Information Center

Bataineh, Ruba Fahmi; Al-Karasneh, Samih Mahmoud; Al-Barakat, Ali Ahmad; Bataineh, Rula Fahmi

2007-01-01

This study investigates how portfolios support pre-service teachers' learning to teach. The findings revealed that the portfolio provides pre-service teachers with productive learning experiences which help them develop their "library use, knowledge, skills, attitudes, personal traits, motivation to learn, interpersonal relationships"…

DPPP: Default Pre-Processing Pipeline

NASA Astrophysics Data System (ADS)

van Diepen, Ger; Dijkema, Tammo Jan

2018-04-01

DPPP (Default Pre-Processing Pipeline, also referred to as NDPPP) reads and writes radio-interferometric data in the form of Measurement Sets, mainly those that are created by the LOFAR telescope. It goes through visibilities in time order and contains standard operations like averaging, phase-shifting and flagging bad stations. Between the steps in a pipeline, the data is not written to disk, making this tool suitable for operations where I/O dominates. More advanced procedures such as gain calibration are also included. Other computing steps can be provided by loading a shared library; currently supported external steps are the AOFlagger (ascl:1010.017) and a bridge that enables loading python steps.

Mass of materials: the impact of designers on construction ergonomics.

PubMed

Smallwood, John

2012-01-01

Many construction injuries are musculoskeletal related in the form of sprains and strains arising from the handling of materials, which are specified by designers. The paper presents the results of a study conducted among delegates attending two 'designing for H&S' (DfH&S) seminars using a questionnaire. The salient findings include: the level of knowledge relative to the mass and density of materials is limited; designers generally do not consider the mass and density of materials when designing structures and elements and specifying materials; to a degree designers appreciate that the mass and density of materials impact on construction ergonomics; designers rate their knowledge of the mass and density of materials as limited, and designers appreciate the potential of the consideration of the mass and density of materials to contribute to an improvement in construction ergonomics. Conclusions include: designers lack the requisite knowledge relative to the mass and density of materials; designers are thus precluded from conducting optimum design hazard identification and risk assessments, and tertiary built environment designer education does not enlighten designers relative to construction ergonomics. Recommendations include: tertiary built environment designer education should construction ergonomics; professional associations should raise the level of awareness relative to construction ergonomics, and design practices should include a category 'mass and density of materials' in their practice libraries.

Information Management. VALA National Conference on Library Automation Proceedings (2nd, Melbourne, Australia, November 28-December 1, 1983). Volume 1.

ERIC Educational Resources Information Center

Cheney, B. J., Ed.

The first of two volumes of a conference proceedings, this document contains the welcome, the opening, the keynote addresses, and the invited papers, as well as a submitted paper by John Gillam which was not available for publication in the pre-prints (Volume 2) prior to the conference. Three addresses are not included in these proceedings and…

Training Effectiveness Evaluation of Device A/F37A-T59

DTIC Science & Technology

1982-07-01

selected airplane by manually setting track, crosstrack, and altitude on thE control panel. Posi ion is maintained by flying the attitude director...simulator’s other design capabilities includes full SKE airdrop simulation, radar simulation, manual or pre-programmed malfunctions, a library of...during IFS testing, this feature was not available for this study. Thus, the instructors had to manually program all mission profiles prior to each

Simulation-Based Abdominal Ultrasound Training - A Systematic Review.

PubMed

Østergaard, M L; Ewertsen, C; Konge, L; Albrecht-Beste, E; Bachmann Nielsen, M

2016-06-01

The aim is to provide a complete overview of the different simulation-based training options for abdominal ultrasound and to explore the evidence of their effect. This systematic review was performed according to the PRISMA guidelines and Medline, Embase, Web of Science, and the Cochrane Library was searched. Articles were divided into three categories based on study design (randomized controlled trials, before-and-after studies and descriptive studies) and assessed for level of evidence using the Oxford Centre for Evidence Based Medicine (OCEBM) system and for bias using the Cochrane Collaboration risk of bias assessment tool. Seventeen studies were included in the analysis: four randomized controlled trials, eight before-and-after studies with pre- and post-test evaluations, and five descriptive studies. No studies scored the highest level of evidence, and 14 had the lowest level. Bias was high for 11 studies, low for four, and unclear for two. No studies used a test with established evidence of validity or examined the correlation between obtained skills on the simulators and real-life clinical skills. Only one study used blinded assessors. The included studies were heterogeneous in the choice of simulator, study design, participants, and outcome measures, and the level of evidence for effect was inadequate. In all studies simulation training was equally or more beneficial than other instructions or no instructions. Study designs had significant built-in bias and confounding issues; therefore, further research should be based on randomized controlled trials using tests with validity evidence and blinded assessors. © Georg Thieme Verlag KG Stuttgart · New York.

The Chandra X-ray Observatory PSF Library

NASA Astrophysics Data System (ADS)

Karovska, M.; Beikman, S. J.; Elvis, M. S.; Flanagan, J. M.; Gaetz, T.; Glotfelty, K. J.; Jerius, D.; McDowell, J. C.; Rots, A. H.

Pre-flight and on-orbit calibration of the Chandra X-Ray Observatory provided a unique base for developing detailed models of the optics and detectors. Using these models we have produced a set of simulations of the Chandra point spread function (PSF) which is available to the users via PSF library files. We describe here how the PSF models are generated and the design and content of the Chandra PSF library files.

Interactive Exhibits Foster Partnership and Engage Diverse Learners at Their Local Libraries

NASA Astrophysics Data System (ADS)

LaConte, K.; Dusenbery, P.; Fitzhugh, G.; Harold, J. B.; Holland, A.

2016-12-01

Learners frequently need to access increasingly complex information to help them understand our changing world. More and more libraries are transforming themselves into places where learners not only access STEM information, but interact with professionals and undertake hands-on learning. Libraries are beginning to position themselves as part of learning ecosystems that contribute to a collective impact on the community. Traveling STEM exhibits are catalyzing these partnerships and engaging students, families, and adults in repeat visits through an accessible venue: their public library. The impact of the STAR Library Education Network's (STAR_Net) Discover Earth: A Century of Change exhibit on partnerships, the circulation of STEM resources, and the engagement of learners was studied by an external evaluation team. The STAR_Net project's summative evaluation utilized mixed methods to investigate project implementation and its outcomes. Methods included pre- and post-exhibit surveys administered to staff from each library that hosted the exhibits; interviews with staff from host libraries; patron surveys; exhibit-related circulation records; web metrics regarding the online STAR_Net community of practice; and site visits. A subset of host libraries recruited professionals, who delivered programming that connected Earth systems science, weather, climate, and conservation themes from the exhibit to local issues. Library patrons improved their knowledge about STEM topics presented in the exhibits and associated programming, and patrons viewing the exhibit reflected the demographics of their communities. In a follow-up survey, patrons reported spending an average of 60 minutes looking at the exhibit over their cumulative visits to the library. In contrast, visitors might visit a museum only once to look at a comparably-sized traveling exhibit due to barriers such as cost and distance. Exhibit host libraries reported an increase in the circulation of Earth science materials of 27% while the exhibit was at their library. The summative evaluation results, as well as tips for working with your local library, will be shared.

Rapid Prototyping in PVS

NASA Technical Reports Server (NTRS)

Munoz, Cesar A.; Butler, Ricky (Technical Monitor)

2003-01-01

PVSio is a conservative extension to the PVS prelude library that provides basic input/output capabilities to the PVS ground evaluator. It supports rapid prototyping in PVS by enhancing the specification language with built-in constructs for string manipulation, floating point arithmetic, and input/output operations.

A study of issues in administering library services to nursing studies students at Glasgow Caledonian University.

PubMed

Crawford, John

2002-06-01

Glasgow Caledonian University has had a Scottish Office pre-registration nursing and midwifery contract since 1996. Nursing studies students seemed dissatisfied with the library service and there were frequent complaints. A major study was undertaken during 2000 consisting of: an initial lis-link enquiry, separate analysis of returns from nursing studies students of the Library's annual general satisfaction survey (conducted every February), separate analysis of returns from nursing studies students of the Library's opening hours planning survey, and four focus groups held in October 2000. These studies showed the concerns of nursing studies students to be similar to other students but more strongly felt. The four main issues were textbook availability, journal availability, opening hours and staff helpfulness. Working conditions, placement requirements, study requirements and domestic circumstances were all found to be important factors. IT skill levels tended to be low but there is a growing appreciation of the need for training in this area. Concluded that: Library's services to nursing studies students have become enmeshed with the problems of delivery and assessment of education for nurses. Greatly extended opening hours are essential including evening opening during vacations. The problem of access to textbooks is so severe that conventional solutions are not going to work. Programmes of core text digitization and the promotion of e-books are needed. Reciprocal access programmes with local hospital libraries is essential.

A Padawan Programmer's Guide to Developing Software Libraries.

PubMed

Yurkovich, James T; Yurkovich, Benjamin J; Dräger, Andreas; Palsson, Bernhard O; King, Zachary A

2017-11-22

With the rapid adoption of computational tools in the life sciences, scientists are taking on the challenge of developing their own software libraries and releasing them for public use. This trend is being accelerated by popular technologies and platforms, such as GitHub, Jupyter, R/Shiny, that make it easier to develop scientific software and by open-source licenses that make it easier to release software. But how do you build a software library that people will use? And what characteristics do the best libraries have that make them enduringly popular? Here, we provide a reference guide, based on our own experiences, for developing software libraries along with real-world examples to help provide context for scientists who are learning about these concepts for the first time. While we can only scratch the surface of these topics, we hope that this article will act as a guide for scientists who want to write great software that is built to last. Copyright © 2017 Elsevier Inc. All rights reserved.

A portable MPI-based parallel vector template library

NASA Technical Reports Server (NTRS)

Sheffler, Thomas J.

1995-01-01

This paper discusses the design and implementation of a polymorphic collection library for distributed address-space parallel computers. The library provides a data-parallel programming model for C++ by providing three main components: a single generic collection class, generic algorithms over collections, and generic algebraic combining functions. Collection elements are the fourth component of a program written using the library and may be either of the built-in types of C or of user-defined types. Many ideas are borrowed from the Standard Template Library (STL) of C++, although a restricted programming model is proposed because of the distributed address-space memory model assumed. Whereas the STL provides standard collections and implementations of algorithms for uniprocessors, this paper advocates standardizing interfaces that may be customized for different parallel computers. Just as the STL attempts to increase programmer productivity through code reuse, a similar standard for parallel computers could provide programmers with a standard set of algorithms portable across many different architectures. The efficacy of this approach is verified by examining performance data collected from an initial implementation of the library running on an IBM SP-2 and an Intel Paragon.

A Portable MPI-Based Parallel Vector Template Library

NASA Technical Reports Server (NTRS)

Sheffler, Thomas J.

1995-01-01

This paper discusses the design and implementation of a polymorphic collection library for distributed address-space parallel computers. The library provides a data-parallel programming model for C + + by providing three main components: a single generic collection class, generic algorithms over collections, and generic algebraic combining functions. Collection elements are the fourth component of a program written using the library and may be either of the built-in types of c or of user-defined types. Many ideas are borrowed from the Standard Template Library (STL) of C++, although a restricted programming model is proposed because of the distributed address-space memory model assumed. Whereas the STL provides standard collections and implementations of algorithms for uniprocessors, this paper advocates standardizing interfaces that may be customized for different parallel computers. Just as the STL attempts to increase programmer productivity through code reuse, a similar standard for parallel computers could provide programmers with a standard set of algorithms portable across many different architectures. The efficacy of this approach is verified by examining performance data collected from an initial implementation of the library running on an IBM SP-2 and an Intel Paragon.

Fortran graphics routines for the Macintosh

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shore, B.W.

1992-06-01

The Language Systems MPW Fortran is a popular Fortran compiler for the Macintosh. Unfortunately, it does not have any built-in calls to graphics routines (such as are available with Graflib on the NLTSS), so there is no simple way to make x-y plots from calls within Fortran. Instead, a file of data must be created and a commercial plotting routine (such as IGOR or KALEIDAGRAPH) or a spreadsheet with graphics (such as WINGZ) must be applied to post-process the data. The Macintosh does have available many built-in calls (to the Macintosh Toolbox) that allow drawing shapes and lines with quickdraw,more » but these are not designed for plotting functions and are difficult to learn to use. This work outlines some Fortran routines that can be called from LS Fortran to make the necessary calls to the Macintosh toolbox to create simple two-dimensional plots or contour plots. The source code DEMOGRAF.F shows how these routines may be used. DEMOGRAF.F simply demonstrates some Fortran subroutines that can be called with language systems MPW Fortran on the Macintosh to plot arrays of numbers. The subroutines essentially mimic the functionality that has been available at LTSS and NLTSS and UNICOS at LLNL. The graphics primitives are kept in four separate files, each containing several subroutines. The subroutines are compiled and stored in a library file, LIBgraf.o. Makefile is used to link this library to the source code. A discussion is included on requirements for interactive plotting of functions.« less

Development of Communities of Practice in School Library Education

ERIC Educational Resources Information Center

Burns, Elizabeth A.; Howard, Jody K.; Kimmel, Sue C.

2016-01-01

To properly prepare pre-service school librarians, school library educators in online courses must provide opportunities for collaborative engagement. This collaborative education should also recognize the pedagogical benefit of the organic formation of communities of practice that develop within areas outside of curriculum content. This…

Climate tools in mainstream Linux distributions

NASA Astrophysics Data System (ADS)

McKinstry, Alastair

2015-04-01

Debian/meterology is a project to integrate climate tools and analysis software into the mainstream Debian/Ubuntu Linux distributions. This work describes lessons learnt, and recommends practices for scientific software to be adopted and maintained in OS distributions. In addition to standard analysis tools (cdo,, grads, ferret, metview, ncl, etc.), software used by the Earth System Grid Federation was chosen for integraion, to enable ESGF portals to be built on this base; however exposing scientific codes via web APIs enables security weaknesses, normally ignorable, to be exposed. How tools are hardened, and what changes are required to handle security upgrades, are described. Secondly, to enable libraries and components (e.g. Python modules) to be integrated requires planning by writers: it is not sufficient to assume users can upgrade their code when you make incompatible changes. Here, practices are recommended to enable upgrades and co-installability of C, C++, Fortran and Python codes. Finally, software packages such as NetCDF and HDF5 can be built in multiple configurations. Tools may then expect incompatible versions of these libraries (e.g. serial and parallel) to be simultaneously available; how this was solved in Debian using "pkg-config" and shared library interfaces is described, and best practices for software writers to enable this are summarised.

Performance of Matrix-Assisted Laser Desorption Ionization−Time of Flight Mass Spectrometry for Identification of Aspergillus, Scedosporium, and Fusarium spp. in the Australian Clinical Setting

PubMed Central

Sleiman, Sue; Halliday, Catriona L.; Chapman, Belinda; Brown, Mitchell; Nitschke, Joanne; Lau, Anna F.

2016-01-01

We developed an Australian database for the identification of Aspergillus, Scedosporium, and Fusarium species (n = 28) by matrix-assisted laser desorption ionization−time of flight mass spectrometry (MALDI-TOF MS). In a challenge against 117 isolates, species identification significantly improved when the in-house-built database was combined with the Bruker Filamentous Fungi Library compared with that for the Bruker library alone (Aspergillus, 93% versus 69%; Fusarium, 84% versus 42%; and Scedosporium, 94% versus 18%, respectively). PMID:27252460

OSCAR4: a flexible architecture for chemical text-mining.

PubMed

Jessop, David M; Adams, Sam E; Willighagen, Egon L; Hawizy, Lezan; Murray-Rust, Peter

2011-10-14

The Open-Source Chemistry Analysis Routines (OSCAR) software, a toolkit for the recognition of named entities and data in chemistry publications, has been developed since 2002. Recent work has resulted in the separation of the core OSCAR functionality and its release as the OSCAR4 library. This library features a modular API (based on reduction of surface coupling) that permits client programmers to easily incorporate it into external applications. OSCAR4 offers a domain-independent architecture upon which chemistry specific text-mining tools can be built, and its development and usage are discussed.

Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library.

PubMed

Huschmann, Franziska U; Linnik, Janina; Sparta, Karine; Ühlein, Monika; Wang, Xiaojie; Metz, Alexander; Schiebel, Johannes; Heine, Andreas; Klebe, Gerhard; Weiss, Manfred S; Mueller, Uwe

2016-05-01

Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screening in both academia and industry. The library is selected from already existing protein-ligand structures and is characterized by a broad ligand diversity, including buffer ingredients, carbohydrates, nucleotides, amino acids, peptide-like fragments and various drug-like organic compounds. When applied to the model protease endothiapepsin in a crystallographic screening experiment, a hit rate of nearly 10% was obtained. In comparison to other fragment libraries and considering that no pre-screening was performed, this hit rate is remarkably high. This demonstrates the general suitability of the selected compounds for an initial fragment-screening campaign. The library composition, experimental considerations and time requirements for a complete crystallographic fragment-screening campaign are discussed as well as the nine fully refined obtained endothiapepsin-fragment structures. While most of the fragments bind close to the catalytic centre of endothiapepsin in poses that have been observed previously, two fragments address new sites on the protein surface. ITC measurements show that the fragments bind to endothiapepsin with millimolar affinity.

Structures of endothiapepsin–fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library

PubMed Central

Huschmann, Franziska U.; Linnik, Janina; Sparta, Karine; Ühlein, Monika; Wang, Xiaojie; Metz, Alexander; Schiebel, Johannes; Heine, Andreas; Klebe, Gerhard; Weiss, Manfred S.; Mueller, Uwe

2016-01-01

Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screening in both academia and industry. The library is selected from already existing protein–ligand structures and is characterized by a broad ligand diversity, including buffer ingredients, carbohydrates, nucleotides, amino acids, peptide-like fragments and various drug-like organic compounds. When applied to the model protease endothiapepsin in a crystallographic screening experiment, a hit rate of nearly 10% was obtained. In comparison to other fragment libraries and considering that no pre-screening was performed, this hit rate is remarkably high. This demonstrates the general suitability of the selected compounds for an initial fragment-screening campaign. The library composition, experimental considerations and time requirements for a complete crystallographic fragment-screening campaign are discussed as well as the nine fully refined obtained endothiapepsin–fragment structures. While most of the fragments bind close to the catalytic centre of endothiapepsin in poses that have been observed previously, two fragments address new sites on the protein surface. ITC measurements show that the fragments bind to endothiapepsin with millimolar affinity. PMID:27139825

Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep).

PubMed

Guellouz, Asma; Valerio-Lepiniec, Marie; Urvoas, Agathe; Chevrel, Anne; Graille, Marc; Fourati-Kammoun, Zaineb; Desmadril, Michel; van Tilbeurgh, Herman; Minard, Philippe

2013-01-01

We previously designed a new family of artificial proteins named αRep based on a subgroup of thermostable helicoidal HEAT-like repeats. We have now assembled a large optimized αRep library. In this library, the side chains at each variable position are not fully randomized but instead encoded by a distribution of codons based on the natural frequency of side chains of the natural repeats family. The library construction is based on a polymerization of micro-genes and therefore results in a distribution of proteins with a variable number of repeats. We improved the library construction process using a "filtration" procedure to retain only fully coding modules that were recombined to recreate sequence diversity. The final library named Lib2.1 contains 1.7×10(9) independent clones. Here, we used phage display to select, from the previously described library or from the new library, new specific αRep proteins binding to four different non-related predefined protein targets. Specific binders were selected in each case. The results show that binders with various sizes are selected including relatively long sequences, with up to 7 repeats. ITC-measured affinities vary with Kd values ranging from micromolar to nanomolar ranges. The formation of complexes is associated with a significant thermal stabilization of the bound target protein. The crystal structures of two complexes between αRep and their cognate targets were solved and show that the new interfaces are established by the variable surfaces of the repeated modules, as well by the variable N-cap residues. These results suggest that αRep library is a new and versatile source of tight and specific binding proteins with favorable biophysical properties.

Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)

PubMed Central

Chevrel, Anne; Graille, Marc; Fourati-Kammoun, Zaineb; Desmadril, Michel; van Tilbeurgh, Herman; Minard, Philippe

2013-01-01

We previously designed a new family of artificial proteins named αRep based on a subgroup of thermostable helicoidal HEAT-like repeats. We have now assembled a large optimized αRep library. In this library, the side chains at each variable position are not fully randomized but instead encoded by a distribution of codons based on the natural frequency of side chains of the natural repeats family. The library construction is based on a polymerization of micro-genes and therefore results in a distribution of proteins with a variable number of repeats. We improved the library construction process using a “filtration” procedure to retain only fully coding modules that were recombined to recreate sequence diversity. The final library named Lib2.1 contains 1.7×109 independent clones. Here, we used phage display to select, from the previously described library or from the new library, new specific αRep proteins binding to four different non-related predefined protein targets. Specific binders were selected in each case. The results show that binders with various sizes are selected including relatively long sequences, with up to 7 repeats. ITC-measured affinities vary with Kd values ranging from micromolar to nanomolar ranges. The formation of complexes is associated with a significant thermal stabilization of the bound target protein. The crystal structures of two complexes between αRep and their cognate targets were solved and show that the new interfaces are established by the variable surfaces of the repeated modules, as well by the variable N-cap residues. These results suggest that αRep library is a new and versatile source of tight and specific binding proteins with favorable biophysical properties. PMID:24014183

Casting an ergonomic eye on university libraries.

PubMed

Ferrer, Nicole; Villarouco, Vilma

2012-01-01

Research in the field of Ergonomics of the Built Environment has been developed with a view to consolidating studies in this area, the objective of which is to provide evidence that the joint participation of users and designers on drawing up projects is important. In this context, the theme of this study is to investigate the interactions between users and the environment in a university library. To do so, well-established techniques from Ergonomics, Architecture and Environmental Psychology were used to make a functional and behavioral evaluation to identify the level of user satisfaction in six libraries in the various study centers of the Federal University of Pernambuco in Recife, northeast Brazil, so as to identify the strengths and also weaknesses in these spatial structures.

Preparing for ENDF/B-VIII

NASA Astrophysics Data System (ADS)

Brown, David

2017-09-01

Although the next major release of the ENDF/B library is not due until the 2017-2018 time frame, ENDF/B-VIII is already positioned to become the most important release of the library in some time. ENDF/B-VIII will be built around the Neutron Reaction Standards as well as the 1H, 16O, 56Fe, 235U, 238U and 239Pu evaluations developed as part of the Coordinated International Evaluation Library Organization (CIELO) pilot project. In this contribution, we summarize these improvements as well as the many other improvements to ENDF that have already been made or are scheduled to be made in the next year. Improvements already included in the ENDF/B-VIII beta releases: • Aggressive use of the flexible and physically correct LRF=7 resolved resonance format in 12 updated evaluations (35,37Cl, 40Ca, 54,56,57Fe, 63,65Cu and 182,183,184,186W) • Thermal capture gammas from the EGAF project (6,7Li, 11B, 19F, 23Na, 27Al, 28Si, 35,37Cl) • Thermal Scattering Law evaluations from NCSU (α and β phase SiO2, SiC, lucite, BeO, and polyethylene) and from the CAB-CNL collaboration (heavy and light water) • Many new evaluations in the neutron sublibrary (n, 12,13C, 40Ar, 54,57,58Fe, 58,59,60,61,62,64Ni, 63,65Cu, 73As, 120Sn, 236m1Np) Inclusion of Red Cullen's EPICS2014 library, updating the photo-atomic, electron and atomic-relaxation sublibraries. Many improvements are planned in the next year including new evaluations such as charged particle evaluations translated from LLNL's ECPL. In addition to these major changes, ENDF/B-VIII will be the first official library released simultaneously in the legacy ENDF-6 and the newly developed Generalized Nuclear Data (GND) formats.

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Markley, Andrew L.; Begemann, Matthew B.; Clarke, Ryan E.

The application of synthetic biology requires characterized tools to precisely control gene expression. This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002. To address this gap, two orthogonal constitutive promoter libraries, one based on a cyanobacterial promoter and the other ported from Escherichia coli, were built and tested in PCC 7002. The libraries demonstrated 3 and 2.5 log dynamic ranges, respectively, but correlated poorly with E. coli expression levels. These promoter libraries were then combined to create and optimize a series of IPTG inducible cassettes. The resultant induction system hadmore » a 48-fold dynamic range and was shown to out-perform P trc constructs. Finally, a RBS library was designed and tested in PCC 7002. The presented synthetic biology toolbox will enable accelerated engineering of PCC 7002.« less

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

DOE PAGES

Markley, Andrew L.; Begemann, Matthew B.; Clarke, Ryan E.; ...

2014-09-12

The application of synthetic biology requires characterized tools to precisely control gene expression. This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002. To address this gap, two orthogonal constitutive promoter libraries, one based on a cyanobacterial promoter and the other ported from Escherichia coli, were built and tested in PCC 7002. The libraries demonstrated 3 and 2.5 log dynamic ranges, respectively, but correlated poorly with E. coli expression levels. These promoter libraries were then combined to create and optimize a series of IPTG inducible cassettes. The resultant induction system hadmore » a 48-fold dynamic range and was shown to out-perform P trc constructs. Finally, a RBS library was designed and tested in PCC 7002. The presented synthetic biology toolbox will enable accelerated engineering of PCC 7002.« less

The Effect of Automation on Job Duties, Classifications, Staffing Patterns, and Labor Costs in the UBC Library's Cataloguing Divisions: A Comparison of 1973 and 1986.

ERIC Educational Resources Information Center

de Bruijn, Erik

This report discusses an ex post facto study that was done to examine the effect that the implementation of automated systems has had on libraries and support staff, labor costs, and productivity in the cataloging divisions of the library of the University of British Columbia. A comparison was made between two years: 1973, a pre-automated period…

Structure and Governance of Library Networks: A Theme Conference Summary. Issues for Consideration. White House Conference on Library and Information Services: Pre-Conference Meetings on Special Themes, November 6-8, 1978.

ERIC Educational Resources Information Center

Galvin, Thomas J.

This paper constitutes a summary of the major topics discussed by the nearly 500 librarians, information specialists, representatives of the information industry, and other interested individuals who participated in a national forum for the identification, elucidation, and discussion of issues relating to library networks, as a contribution to the…

Avionics System Architecture Tool

NASA Technical Reports Server (NTRS)

Chau, Savio; Hall, Ronald; Traylor, marcus; Whitfield, Adrian

2005-01-01

Avionics System Architecture Tool (ASAT) is a computer program intended for use during the avionics-system-architecture- design phase of the process of designing a spacecraft for a specific mission. ASAT enables simulation of the dynamics of the command-and-data-handling functions of the spacecraft avionics in the scenarios in which the spacecraft is expected to operate. ASAT is built upon I-Logix Statemate MAGNUM, providing a complement of dynamic system modeling tools, including a graphical user interface (GUI), modeling checking capabilities, and a simulation engine. ASAT augments this with a library of predefined avionics components and additional software to support building and analyzing avionics hardware architectures using these components.

Information empowerment: predeparture resource training for students in global health.

PubMed

Rana, Gurpreet K

2014-04-01

The Taubman Health Sciences Library (THL) collaborates with health sciences schools to provide information skills instruction for students preparing for international experiences. THL enhances students' global health learning through predeparture instruction for students who are involved in global health research, clinical internships, and international collaborations. This includes teaching international literature searching skills, providing country-specific data sources, building awareness of relevant mobile resources, and encouraging investigation of international news. Information skills empower creation of stronger global partnerships. Use of information resources has enhanced international research and training experiences, built lifelong learning foundations, and contributed to the university's global engagement. THL continues to assess predeparture instruction.

Question-Negotiation and Information Seeking in Libraries

ERIC Educational Resources Information Center

Taylor, Robert S.

2015-01-01

Seekers of information in libraries either go through a librarian intermediary or they help themselves. When they go through librarians they must develop their questions through four levels of need, referred to here as the visceral, conscious, formalized, and compromised needs. In his pre-search interview with an information-seeker the reference…

Sirocco Storage Server v. pre-alpha 0.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curry, Matthew L.; Danielson, Geoffrey; Ward, H. Lee

Sirocco is a parallel storage system under development, designed for write-intensive workloads on large-scale HPC platforms. It implements a keyvalue object store on top of a set of loosely federated storage servers that cooperate to ensure data integrity and performance. It includes support for a range of different types of storage transactions. This software release constitutes a conformant storage server, along with the client-side libraries to access the storage over a network.

A Guide to the Study of the United States of America. Representative Books Reflecting the Development of American Life and Thought. Supplement 1956-1965.

ERIC Educational Resources Information Center

Orr, Oliver H., Jr.; And Others

This supplement to the 1960 edition of "A Guide to the Study of the United States of America" contains titles held by the Library of Congress that reflect the development of the United States and were published between 1956 and 1965. In some instances a few pre-1956 publications are entered. These include parts of series or multivolume…

Aerospace Toolbox---a flight vehicle design, analysis, simulation ,and software development environment: I. An introduction and tutorial

NASA Astrophysics Data System (ADS)

Christian, Paul M.; Wells, Randy

2001-09-01

This paper presents a demonstrated approach to significantly reduce the cost and schedule of non real-time modeling and simulation, real-time HWIL simulation, and embedded code development. The tool and the methodology presented capitalize on a paradigm that has become a standard operating procedure in the automotive industry. The tool described is known as the Aerospace Toolbox, and it is based on the MathWorks Matlab/Simulink framework, which is a COTS application. Extrapolation of automotive industry data and initial applications in the aerospace industry show that the use of the Aerospace Toolbox can make significant contributions in the quest by NASA and other government agencies to meet aggressive cost reduction goals in development programs. The part I of this paper provides a detailed description of the GUI based Aerospace Toolbox and how it is used in every step of a development program; from quick prototyping of concept developments that leverage built-in point of departure simulations through to detailed design, analysis, and testing. Some of the attributes addressed include its versatility in modeling 3 to 6 degrees of freedom, its library of flight test validated library of models (including physics, environments, hardware, and error sources), and its built-in Monte Carlo capability. Other topics to be covered in this part include flight vehicle models and algorithms, and the covariance analysis package, Navigation System Covariance Analysis Tools (NavSCAT). Part II of this paper, to be published at a later date, will conclude with a description of how the Aerospace Toolbox is an integral part of developing embedded code directly from the simulation models by using the Mathworks Real Time Workshop and optimization tools. It will also address how the Toolbox can be used as a design hub for Internet based collaborative engineering tools such as NASA's Intelligent Synthesis Environment (ISE) and Lockheed Martin's Interactive Missile Design Environment (IMD).

Dollars and Sense: A Review of Economic Analyses of Pre-K. Pre-K Now Research Series

ERIC Educational Resources Information Center

Wat, Albert

2007-01-01

The momentum behind high-quality, voluntary pre-kindergarten is growing dramatically across the country--in families, in communities, and in the halls of academia and government. Thanks to this strong wave of support, state spending on pre-k increased from $2.4 billion to $4.2 billion nationwide between 2002 and 2007. This investment is built upon…

Evaluation of the built environment: staff and family satisfaction pre- and post-occupancy of the Children's Hospital.

PubMed

Kotzer, Anne Marie; Zacharakis, Susan Koch; Raynolds, Mary; Buenning, Fred

2011-01-01

To evaluate and compare the impact of an existing and newly built hospital environment on family and staff satisfaction related to light, noise, temperature, aesthetics, and amenities, as well as safety, security, and privacy. The United States is engaged in an unprecedented healthcare building boom driven by the need to replace aging facilities, understand the impact of the built environment on quality and safety, incorporate rapidly emerging technologies, and enhance patient- and family-centered care. More importantly, there is heightened attention to creating optimal physical environments to achieve the best possible outcomes for patients, families, and staff. Using a pre-post descriptive survey design, all nursing, social work, therapy staff, and families on selected inpatient units were invited to participate. A demographic form and Family and Staff Satisfaction Surveys were developed and administered pre- and post-occupancy of the new facility. Pre/post mean scores for staff satisfaction improved on all survey subscales with statistically significant improvement (p < .05) in most areas. The most improvement was seen with layout of the patient room, natural light, storage and writing surfaces, and comfort and appeal. Family satisfaction demonstrated statistically significant improvement on all subscales (p ≤ .01), especially for natural light, quiet space, parking, and the child's room as a healing environment. Families and staff reported greater satisfaction with the newly built hospital environment compared to the old facility. Study results will help guide future architectural design decisions, attract and retain staff at a world-class facility, and create the most effective healing environments.

Light-ion Production from O, Si, Fe and Bi Induced by 175 MeV Quasi-monoenergetic Neutrons

NASA Astrophysics Data System (ADS)

Bevilacqua, R.; Pomp, S.; Jansson, K.; Gustavsson, C.; Österlund, M.; Simutkin, V.; Hayashi, M.; Hirayama, S.; Naitou, Y.; Watanabe, Y.; Hjalmarsson, A.; Prokofiev, A.; Tippawan, U.; Lecolley, F.-R.; Marie, N.; Leray, S.; David, J.-C.; Mashnik, S.

2014-05-01

We have measured double-differential cross sections in the interaction of 175 MeV quasi-monoenergetic neutrons with O, Si, Fe and Bi. We have compared these results with model calculations with INCL4.5-Abla07, MCNP6 and TALYS-1.2. We have also compared our data with PHITS calculations, where the pre-equilibrium stage of the reaction was accounted respectively using the JENDL/HE-2007 evaluated data library, the quantum molecular dynamics model (QMD) and a modified version of QMD (MQMD) to include a surface coalescence model. The most crucial aspect is the formation and emission of composite particles in the pre-equilibrium stage.

Strongly Coupled Fluid-Body Dynamics in the Immersed Boundary Projection Method

NASA Astrophysics Data System (ADS)

Wang, Chengjie; Eldredge, Jeff D.

2014-11-01

A computational algorithm is developed to simulate dynamically coupled interaction between fluid and rigid bodies. The basic computational framework is built upon a multi-domain immersed boundary method library, whirl, developed in previous work. In this library, the Navier-Stokes equations for incompressible flow are solved on a uniform Cartesian grid by the vorticity-based immersed boundary projection method of Colonius and Taira. A solver for the dynamics of rigid-body systems is also included. The fluid and rigid-body solvers are strongly coupled with an iterative approach based on the block Gauss-Seidel method. Interfacial force, with its intimate connection with the Lagrange multipliers used in the fluid solver, is used as the primary iteration variable. Relaxation, developed from a stability analysis of the iterative scheme, is used to achieve convergence in only 2-4 iterations per time step. Several two- and three-dimensional numerical tests are conducted to validate and demonstrate the method, including flapping of flexible wings, self-excited oscillations of a system of linked plates and three-dimensional propulsion of flexible fluked tail. This work has been supported by AFOSR, under Award FA9550-11-1-0098.

Immune Antibody Libraries: Manipulating The Diverse Immune Repertoire for Antibody Discovery.

PubMed

Lim, Theam Soon; Chan, Soo Khim

2016-01-01

Antibody phage display is highly dependent on the availability of antibody libraries. There are several forms of libraries depending mainly on the origin of the source materials. There are three major classes of libraries, mainly the naïve, immune and synthetic libraries. Immune antibody libraries are designed to isolate specific and high affinity antibodies against disease antigens. The pre-exposure of the host to an infection results in the production of a skewed population of antibodies against the particular infection. This characteristic takes advantage of the in vivo editing machinery to generate bias and specific immune repertoire. The skewed but diverse repertoire of immune libraries has been adapted successfully in the generation of antibodies against a wide range of diseases. We envisage immune antibody libraries to play a greater role in the discovery of antibodies for diseases in the near future. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

OPAL: An Open-Source MPI-IO Library over Cray XT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Weikuan; Vetter, Jeffrey S; Canon, Richard Shane

Parallel IO over Cray XT is supported by a vendor-supplied MPI-IO package. This package contains a proprietary ADIO implementation built on top of the sysio library. While it is reasonable to maintain a stable code base for application scientists' convenience, it is also very important to the system developers and researchers to analyze and assess the effectiveness of parallel IO software, and accordingly, tune and optimize the MPI-IO implementation. A proprietary parallel IO code base relinquishes such flexibilities. On the other hand, a generic UFS-based MPI-IO implementation is typically used on many Linux-based platforms. We have developed an open-source MPI-IOmore » package over Lustre, referred to as OPAL (OPportunistic and Adaptive MPI-IO Library over Lustre). OPAL provides a single source-code base for MPI-IO over Lustre on Cray XT and Linux platforms. Compared to Cray implementation, OPAL provides a number of good features, including arbitrary specification of striping patterns and Lustre-stripe aligned file domain partitioning. This paper presents the performance comparisons between OPAL and Cray's proprietary implementation. Our evaluation demonstrates that OPAL achieves the performance comparable to the Cray implementation. We also exemplify the benefits of an open source package in revealing the underpinning of the parallel IO performance.« less

Signal processing and general purpose data acquisition system for on-line tomographic measurements

NASA Astrophysics Data System (ADS)

Murari, A.; Martin, P.; Hemming, O.; Manduchi, G.; Marrelli, L.; Taliercio, C.; Hoffmann, A.

1997-01-01

New analog signal conditioning electronics and data acquisition systems have been developed for the soft x-ray and bolometric tomography diagnostic in the reverse field pinch experiment (RFX). For the soft x-ray detectors the analog signal processing includes a fully differential current to voltage conversion, with up to a 200 kHz bandwidth. For the bolometers, a 50 kHz carrier frequency amplifier allows a maximum bandwidth of 10 kHz. In both cases the analog signals are digitized with a 1 MHz sampling rate close to the diagnostic and are transmitted via a transparent asynchronous xmitter/receiver interface (TAXI) link to purpose built Versa Module Europa (VME) modules which perform data acquisition. A software library has been developed for data preprocessing and tomographic reconstruction. It has been written in C language and is self-contained, i.e., no additional mathematical library is required. The package is therefore platform-free: in particular it can perform online analysis in a real-time application, such as continuous display and feedback, and is portable for long duration fusion or other physical experiments. Due to the modular organization of the library, new preprocessing and analysis modules can be easily integrated in the environment. This software is implemented in RFX over three different platforms: open VMS, digital Unix, and VME 68040 CPU.

Pre-pregnancy care for women with pre-gestational diabetes mellitus: a systematic review and meta-analysis.

PubMed

Wahabi, Hayfaa A; Alzeidan, Rasmieh A; Esmaeil, Samia A

2012-09-17

Pre-gestational diabetes mellitus is associated with increased risk for maternal and fetal adverse outcomes. This systematic review was carried out to evaluate the effectiveness and safety of pre-pregnancy care in improving the rate of congenital malformations and perinatal mortality for women with pre-gestational diabetes mellitus. We searched the following databases, MEDLINE, EMBASE, WEB OF SCIENCE, Cochrane Library, including the CENTRAL register of controlled trials and CINHAL up to December 2011, without language restriction, for any pre-pregnancy care aiming at health promotion, glycemic control and screening and treatment of diabetes complications in women with type I or type II diabetes mellitus. Study design were trials (randomized and non-randomized), cohort and case-control studies. Of the 2452 title scanned 54 full papers were retrieved of those 21 studies were included in this review. Twelve cohort studies at low and medium risk of bias, with 3088 women, were included in the meta-analysis. Meta-analysis suggested that pre-pregnancy care is effective in reducing congenital malformation, Risk Ratio (RR) 0.25 (95% CI 0.16-0.37), number needed to treat (NNT) 19 (95% CI 14-24), and perinatal mortality RR 0.34 (95% CI 0.15-0.75), NNT = 46 (95% CI 28-115). Pre-pregnancy care lowers glycosylated hemoglobin A1c (HbA1c) in the first trimester of pregnancy by an average of 1.92% (95% CI -2.05 to -1.79). However women who received pre-pregnancy care were at increased risk of hypoglycemia during the first trimester of pregnancy RR 1.51 (95% CI 1.15-1.99). Pre-pregnancy care for women with pre-gestational type 1 or type 2 diabetes mellitus is effective in improving rates of congenital malformations, perinatal mortality and in reducing maternal HbA1C in the first trimester of pregnancy. Pre-pregnancy care might cause maternal hypoglycemia in the first trimester of pregnancy.

Breast Cancer Tissue Bioreactor for Direct Interrogation and Observation of Response to Antitumor Therapies

DTIC Science & Technology

2012-07-01

regulate microfluidic flow rates within the TTB, including flow channel height variation and incorporation of valves (see Figure 2 and Supplemental...cartridge. As an alternative to individual channel TURN valve -adjusted flow regulators, we investigated use of pre-fabricated microfluidic flow resistance...Small Parts, Inc. and B) Microfluidic manifolds with built-in TURN valves . Supplemental Figure S3. Simplified 2D and 3D diffusional model

Exploring the Influence of Environment on the Spatial Behavior of Older Adults in a Purpose-Built Acute Care Dementia Unit.

PubMed

Mazzei, Francesco; Gillan, Roslyn; Cloutier, Denise

2014-06-01

Limited research explores the experience of individuals with dementia in acute care geriatric psychiatry units. This observational case study examines the influence of the physical environment on behavior (wandering, pacing, door testing, congregation and seclusions) among residents in a traditional geriatric psychiatry unit who were then relocated to a purpose-built acute care unit. Purpose-built environments should be well suited to the needs of residents with dementia. Observed trends revealed differences in spatial behaviors in the pre- and post- environments attributable to the physical environment. Person-centred modifications to the current environment including concerted efforts to know residents are meaningful in fostering quality of life. Color coded environments (rooms vs dining areas etc.) to improve wayfinding and opportunities to personalize rooms that address the `hominess' of the setting also have potential. Future research could also seek the opinions of staff about the impact of the environment on them as well as residents. © The Author(s) 2013.

Graduate Student Library Research Skills: Is Online Instruction Effective?

ERIC Educational Resources Information Center

Shaffer, Barbara A.

2011-01-01

Graduate students are a significant segment in online instruction programs, yet little is known about how well they learn the necessary library research skills in this increasingly popular mode of distance learning. This pre- and posttest study and citation analysis examined learning and confidence among students in graduate education programs,…

PlantCAZyme: a database for plant carbohydrate-active enzymes

PubMed Central

Ekstrom, Alexander; Taujale, Rahil; McGinn, Nathan; Yin, Yanbin

2014-01-01

PlantCAZyme is a database built upon dbCAN (database for automated carbohydrate active enzyme annotation), aiming to provide pre-computed sequence and annotation data of carbohydrate active enzymes (CAZymes) to plant carbohydrate and bioenergy research communities. The current version contains data of 43 790 CAZymes of 159 protein families from 35 plants (including angiosperms, gymnosperms, lycophyte and bryophyte mosses) and chlorophyte algae with fully sequenced genomes. Useful features of the database include: (i) a BLAST server and a HMMER server that allow users to search against our pre-computed sequence data for annotation purpose, (ii) a download page to allow batch downloading data of a specific CAZyme family or species and (iii) protein browse pages to provide an easy access to the most comprehensive sequence and annotation data. Database URL: http://cys.bios.niu.edu/plantcazyme/ PMID:25125445

The development of a vulnerabilities indicator library for coastal flood risk management at a European scale

NASA Astrophysics Data System (ADS)

Owen, Damon; Viavattene, Christophe; Priest, Sally; Micou, Paula; Parker, Dennis

2015-04-01

Recent and historic low-frequency, high-impact events (Xynthia, Ligurian Flash Floods, the 1953 North Sea storm surge etc) have demonstrated the flood risks faced by exposed coastal areas in Europe. The hazard probability is likely to increase due to a changing climate with more frequent and violent instances of surge-driven floods, wind damage, erosion, overtopping and rain-driven flash flooding. The number and value of receptors in the coastal area also increases due to continued economic development and population growth. As part of the FP7 EU RISCKIT (Resilience-Increasing Strategies for Coasts toolkit) project, a coastal vulnerability indicator library has been produced incorporating ecosystems, built environment, human population, critical infrastructure and the overall characteristics of the coastal system. The library will include data at European, national and local levels and will be gathered, in large part, through a multitude of interviews with various members of the coastal community at 11 case study sites across Europe. The presentation will give a brief outline of the challenges in developing vulnerability indicators - particularly for countries where specific data is limited or lacking - and how the library will be organised to facilitate the use of the data. Finally, the presentation will describe how the vulnerability library will feed into a Coastal Risk Assessment Framework (CRAF). The CRAF will evaluate coastal risk at regional scale and identify "hot spots" to assist coastal practitioners to choose the best prevention, mitigation and preparedness measures for their coast. The work described in this abstract was supported by the European Community's 7th Framework Programme through the grant to the budget of RISC-KIT, contract no. 603458, and by contributions by the partner institutes.

Architecting New Library Frameworks

ERIC Educational Resources Information Center

Breeding, Marshall

2010-01-01

People live in an era of social, enterprise-oriented, and increasingly cloud-based technology; a dramatic shift away from stand-alone isolated silos that previously dominated. Computing systems can flourish today only when built to easily exchange data and services. An application that stands alone may provide practical functionality but may not…

Designed for Learning: Inside and Out.

ERIC Educational Resources Information Center

Sutton, Rodney K.

1996-01-01

Built 7 years after the original plan and budget were approved, Brunswick High School (Maine) houses 1,200 students on 50 acres and contains the latest technological features. Among these are energy management systems that students can see firsthand, a traditional library with 21st-century features, and interactive environmental learning from…

Design and Development of Web-Based Information Literacy Tutorials

ERIC Educational Resources Information Center

Su, Shiao-Feng; Kuo, Jane

2010-01-01

The current study conducts a thorough content analysis of recently built or up-to-date high-quality web-based information literacy tutorials contributed by academic libraries in a peer-reviewed database, PRIMO. This research analyzes the topics/skills PRIMO tutorials consider essential and the teaching strategies they consider effective. The…

SLEEC: Semantics-Rich Libraries for Effective Exascale Computation. Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milind, Kulkarni

SLEEC (Semantics-rich Libraries for Effective Exascale Computation) was a project funded by the Department of Energy X-Stack Program, award number DE-SC0008629. The initial project period was September 2012–August 2015. The project was renewed for an additional year, expiring August 2016. Finally, the project received a no-cost extension, leading to a final expiry date of August 2017. Modern applications, especially those intended to run at exascale, are not written from scratch. Instead, they are built by stitching together various carefully-written, hand-tuned libraries. Correctly composing these libraries is difficult, but traditional compilers are unable to effectively analyze and transform across abstraction layers.more » Domain specific compilers integrate semantic knowledge into compilers, allowing them to transform applications that use particular domain-specific languages, or domain libraries. But they do not help when new domains are developed, or applications span multiple domains. SLEEC aims to fix these problems. To do so, we are building generic compiler and runtime infrastructures that are semantics-aware but not domain-specific. By performing optimizations related to the semantics of a domain library, the same infrastructure can be made generic and apply across multiple domains.« less

A Compilation of MATLAB Scripts and Functions for MACGMC Analyses

NASA Technical Reports Server (NTRS)

Murthy, Pappu L. N.; Bednarcyk, Brett A.; Mital, Subodh K.

2017-01-01

The primary aim of the current effort is to provide scripts that automate many of the repetitive pre- and post-processing tasks associated with composite materials analyses using the Micromechanics Analysis Code with the Generalized Method of Cells. This document consists of a compilation of hundreds of scripts that were developed in MATLAB (The Mathworks, Inc., Natick, MA) programming language and consolidated into 16 MATLAB functions. (MACGMC). MACGMC is a composite material and laminate analysis software code developed at NASA Glenn Research Center. The software package has been built around the generalized method of cells (GMC) family of micromechanics theories. The computer code is developed with a user-friendly framework, along with a library of local inelastic, damage, and failure models. Further, application of simulated thermo-mechanical loading, generation of output results, and selection of architectures to represent the composite material have been automated to increase the user friendliness, as well as to make it more robust in terms of input preparation and code execution. Finally, classical lamination theory has been implemented within the software, wherein GMC is used to model the composite material response of each ply. Thus, the full range of GMC composite material capabilities is available for analysis of arbitrary laminate configurations as well. The pre-processing tasks include generation of a multitude of different repeating unit cells (RUCs) for CMCs and PMCs, visualization of RUCs from MACGMC input and output files and generation of the RUC section of a MACGMC input file. The post-processing tasks include visualization of the predicted composite response, such as local stress and strain contours, damage initiation and progression, stress-strain behavior, and fatigue response. In addition to the above, several miscellaneous scripts have been developed that can be used to perform repeated Monte-Carlo simulations to enable probabilistic simulations with minimal manual intervention. This document is formatted to provide MATLAB source files and descriptions of how to utilize them. It is assumed that the user has a basic understanding of how MATLAB scripts work and some MATLAB programming experience.

Performance of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Aspergillus, Scedosporium, and Fusarium spp. in the Australian Clinical Setting.

PubMed

Sleiman, Sue; Halliday, Catriona L; Chapman, Belinda; Brown, Mitchell; Nitschke, Joanne; Lau, Anna F; Chen, Sharon C-A

2016-08-01

We developed an Australian database for the identification of Aspergillus, Scedosporium, and Fusarium species (n = 28) by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). In a challenge against 117 isolates, species identification significantly improved when the in-house-built database was combined with the Bruker Filamentous Fungi Library compared with that for the Bruker library alone (Aspergillus, 93% versus 69%; Fusarium, 84% versus 42%; and Scedosporium, 94% versus 18%, respectively). Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Logic Model Checking of Time-Periodic Real-Time Systems

NASA Technical Reports Server (NTRS)

Florian, Mihai; Gamble, Ed; Holzmann, Gerard

2012-01-01

In this paper we report on the work we performed to extend the logic model checker SPIN with built-in support for the verification of periodic, real-time embedded software systems, as commonly used in aircraft, automobiles, and spacecraft. We first extended the SPIN verification algorithms to model priority based scheduling policies. Next, we added a library to support the modeling of periodic tasks. This library was used in a recent application of the SPIN model checker to verify the engine control software of an automobile, to study the feasibility of software triggers for unintended acceleration events.

OSCAR4: a flexible architecture for chemical text-mining

PubMed Central

2011-01-01

The Open-Source Chemistry Analysis Routines (OSCAR) software, a toolkit for the recognition of named entities and data in chemistry publications, has been developed since 2002. Recent work has resulted in the separation of the core OSCAR functionality and its release as the OSCAR4 library. This library features a modular API (based on reduction of surface coupling) that permits client programmers to easily incorporate it into external applications. OSCAR4 offers a domain-independent architecture upon which chemistry specific text-mining tools can be built, and its development and usage are discussed. PMID:21999457

It Can Be Done: With Advocacy, Libraries Can Thrive on Pacific Islands. Selected Papers from PIALA 2007, Pacific Islands Association of Libraries, Archives and Museums Annual Conference (17th, Tinian and Saipan, Commonwealth of the Northern Mariana Islands, November 12-17, 2007)

ERIC Educational Resources Information Center

Horie, Ruth H., Ed.

2010-01-01

This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. The volume begins with a listing of the members of the PIALA 2007 Planning Committee, the Officers and Executive Board, and Acknowledgements, followed by the Pre-Conference Workshop…

Strategies for the construction and use of peptide and antibody libraries displayed on phages.

PubMed

Pini, Alessandro; Giuliani, Andrea; Ricci, Claudia; Runci, Ylenia; Bracci, Luisa

2004-12-01

Combinatorial chemistry and biology have become popular methods for the identification of bio-active molecules in drug discovery. A widely used technique in combinatorial biology is "phage display", by which peptides, antibody fragments and enzymes are displayed on the surface of bacteriophages, and can be selected by simple procedures of biopanning. The construction of phage libraries of peptides or antibody fragments provides a huge source of ligands and bio-active molecules that can be isolated from the library without laborious studies on antigen characteristics and prediction of ligand structure. This "irrational" approach for the construction of new drugs is extremely rapid and is now used by thousands of laboratories world-wide. The bottleneck in this procedure is the availability of large reliable libraries that can be used repeatedly over the years without loss of ligand expression and diversity. Construction of personalized libraries is therefore important for public and private laboratories engaged in the isolation of specific molecules for therapeutic or diagnostic use. Here we report the general strategies for constructing large phage peptide and antibody libraries, based on the experience of researchers who built the world's most widely used libraries. Particular attention is paid to advanced strategies for the construction, preservation and panning.

Case study: the health SmartLibrary experiences in web personalization and customization at the Galter health sciences library, Northwestern University.

PubMed

Shedlock, James; Frisque, Michelle; Hunt, Steve; Walton, Linda; Handler, Jonathan; Gillam, Michael

2010-04-01

How can the user's access to health information, especially full-text articles, be improved? The solution is building and evaluating the Health SmartLibrary (HSL). The setting is the Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University. The HSL was built on web-based personalization and customization tools: My E-Resources, Stay Current, Quick Search, and File Cabinet. Personalization and customization data were tracked to show user activity with these value-added, online services. Registration data indicated that users were receptive to personalized resource selection and that the automated application of specialty-based, personalized HSLs was more frequently adopted than manual customization by users. Those who did customize customized My E-Resources and Stay Current more often than Quick Search and File Cabinet. Most of those who customized did so only once. Users did not always take advantage of the services designed to aid their library research experiences. When personalization is available at registration, users readily accepted it. Customization tools were used less frequently; however, more research is needed to determine why this was the case.

The long tail: a usage analysis of pre-1993 print biomedical journal literature

PubMed Central

Starr, Susan; Williams, Jeff

2008-01-01

Objective: The research analyzes usage of a major biomedical library's pre-1993 print journal collection. Methodology: In July 2003, in preparation for a renovation and expansion project, the Biomedical Library at the University of California, San Diego, moved all of its pre-1993 journal volumes off-site, with the exception of twenty-two heavily used titles. Patrons wishing to consult one of these stored volumes could request that it be delivered to the library for their use. In the spring of 2006, an analysis was made of these requests. Results: By July of 2006, 79,827 journal volumes published in 1992 or earlier had been requested from storage. The number of requests received declined with age of publication. The usage distribution exhibited a “long tail”: 50% of the 79,827 requests were for journal volumes published before 1986. The availability of electronic access dramatically reduced the chance that corresponding print journal volumes would be requested. Conclusions: The older biomedical print journal literature appears to be of continued value to the biomedical research community. When electronic access was provided to the older literature, demand for older print volumes declined dramatically. PMID:18219377

A Physics-Based Approach for Power Integrity in Multi-Layered PCBs

NASA Astrophysics Data System (ADS)

Zhao, Biyao

Developing a power distribution network (PDN) for ASICs and ICs to achieve the low-voltage ripple specifications for current digital designs is challenging with the high-speed and low-voltage ICs. Present methods are typically guided by best engineering practices for low impedance looking into the PDN from the IC. A pre-layout design methodology for power integrity in multi-layered PCB PDN geometry is proposed in the thesis. The PCB PDN geometry is segmented into four parts and every part is modelled using different methods based on the geometry details of the part. Physics-based circuit models are built for every part and the four parts are re-assembled into one model. The influence of geometry details is clearly revealed in this methodology. Based on the physics-based circuit mode, the procedures of using the pre-layout design methodology as a guideline during the PDN design is illustrated. Some common used geometries are used to build design space, and the design curves with the geometry details are provided to be a look up library for engineering use. The pre-layout methodology is based on the resonant cavity model of parallel planes for the cavity structures, and parallel-plane PEEC (PPP) for the irregular shaped plane inductance, and PEEC for the decoupling capacitor connection above the top most or bottom most power-return planes. PCB PDN is analyzed based on the input impedance looking into the PCB from the IC. The pre-layout design methodology can be used to obtain the best possible PCB PDN design. With the switching current profile, the target impedance can be selected to evaluate the PDN performance, and the frequency domain PDN input impedance can be used to obtain the voltage ripple in the time domain to give intuitive insight of the geometry impact on the voltage ripple.

Detailed finite element analysis and preliminary study of the effects of friction and fastener pre-tension on the mechanical behavior of fastened built-up members

NASA Astrophysics Data System (ADS)

Bonachera Martin, Francisco Javier

The characterization of fatigue resistance is one of the main concerns in structural engineering, a concern that is particularly important in the evaluation of existing bridge members designed or erected before the development of fatigue design provisions. The ability of a structural member to develop alternate load paths after the failure of a component is known as member-level or internal redundancy. In fastened built-up members, these alternate load paths are affected by the combination of fastener pre-tension and friction between the structural member components in contact. In this study, a finite element methodology to model and analyze riveted and bolted built-up members was developed in ABAQUS and validated with experimental results. This methodology was used to created finite element models of three fastened plates subjected to tension, in which the middle plate had failed, in order to investigate the fundamental effects of combined fastener pre-tension and friction on their mechanical behavior. Detailed finite element models of riveted and bolted built-up flexural members were created and analyze to understand the effect of fastener pre-tension in member-level redundancy and resistance to fatigue and fracture. The obtained results showed that bolted members are able to re-distribute a larger portion of the load away from the failing component into the rest of the member than riveted members, and that this transfer of load also took place over a smaller length. Superior pre-tension of bolts, in comparison to rivets, results in larger frictional forces that develop at the contact interfaces between components and constitute additional alternate load paths that increase member-level redundancy which increase the fatigue and fracture resistance of the structural member during the failure of one of its components. Although fatigue and fracture potential may be mitigated by compressive stresses developing around the fastener hole due to fastener pre-tension, it was also observed, that at the surface of the fastener hole and at the contact interface with another plate, tensional stresses could develop; however, further computational and experimental work should be performed to verify this claim.

SOME PRACTICAL MODIFICATIONS ON HIGH FREQUENCY ION SOURCES (in Hungarian)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagy, J.; Gombos, P.

1962-05-01

A radiofrequency ion source was constructed for the 800-kv cascade type accelerator and 300-kv neutron generator built in the Institute. Besides the usual transversal magnetic field of 50 gauss, an axial magnetic field of 250 gauss intensity was also applied in the immediate neighborhood of the probe. As a result of this, the service life of the discharge tube was increased by several hundred hours but in comparison with the measurements of other authors the percentage of protons underwent no change. The quartz calyx which was built to surround the probe, contributed considerably to an increase of the service life.more » Measurements concerning the selection of the pre-focusing lens are summarized. With a probe of 1.3-mm canal diameter, a maximum 1.9 ma pre-focused ion current was obtained in H/sub 2/ with a gas consumption of 8 to 10 cm/sup 3//hr, (With a probe of 1.7-mm canal diameter, at a gas consumption of 25 cm/sup 3//hr, 2.7 ma current was obtained.) The total consumption of the ion source amounted to 800 w with prefocusing. The energy-spread of the ion beam was found to be 200 ev. Having built it into the cascade type accelerator 1 ma current was measured on the target at an accelerating voltage of 500 kv, where this amount included the secondary electrons as well. (auth)« less

Design and "restoration": the Roots of Architecture Porject for the Built

NASA Astrophysics Data System (ADS)

Campanella, C.

2017-05-01

It is absolutely essential now to prepare a project of pre-critical understanding of the building which will be the object of action, free from preconceived notions of value, fully committed to the implementation of a variety of useful and indispensable to determine that operating margin and freedom that each architecture has not being linked uniquely to the precise original function. This is the margin that you can leverage to implement the architectural project for the built that mutuerà inside knowledge, conservation and innovation at the same time. The binomials in the lead paragraph as all sides of the same coin that merge into one integrated design process that takes charge of design including those different styles of drafting of survey (in all aspects) of an existing architecture.

The Keck keyword layer

NASA Technical Reports Server (NTRS)

Conrad, A. R.; Lupton, W. F.

1992-01-01

Each Keck instrument presents a consistent software view to the user interface programmer. The view consists of a small library of functions, which are identical for all instruments, and a large set of keywords, that vary from instrument to instrument. All knowledge of the underlying task structure is hidden from the application programmer by the keyword layer. Image capture software uses the same function library to collect data for the image header. Because the image capture software and the instrument control software are built on top of the same keyword layer, a given observation can be 'replayed' by extracting keyword-value pairs from the image header and passing them back to the control system. The keyword layer features non-blocking as well as blocking I/O. A non-blocking keyword write operation (such as setting a filter position) specifies a callback to be invoked when the operation is complete. A non-blocking keyword read operation specifies a callback to be invoked whenever the keyword changes state. The keyword-callback style meshes well with the widget-callback style commonly used in X window programs. The first keyword library was built for the two Keck optical instruments. More recently, keyword libraries have been developed for the infrared instruments and for telescope control. Although the underlying mechanisms used for inter-process communication by each of these systems vary widely (Lick MUSIC, Sun RPC, and direct socket I/O, respectively), a basic user interface has been written that can be used with any of these systems. Since the keyword libraries are bound to user interface programs dynamically at run time, only a single set of user interface executables is needed. For example, the same program, 'xshow', can be used to display continuously the telescope's position, the time left in an instrument's exposure, or both values simultaneously. Less generic tools that operate on specific keywords, for example an X display that controls optical instrument exposures, have also been written using the keyword layer.

Assessing the Utilization Level of E-Learning Resources among ODL Based Pre-Service Teacher Trainees

ERIC Educational Resources Information Center

Olaniran, Sunday O.; Duma, M. A. N.; Nzima, D. R.

2017-01-01

Electronic resources have become a dominant feature of higher education, both traditional and distance learning based. Unlike in the past when universities relied majorly on the physical library and hard copy of books, e-books accessible through e-libraries are the dominant features of this century's institutions of higher learning. This study…

Monte Carlo simulation of energy-dispersive x-ray fluorescence and applications

NASA Astrophysics Data System (ADS)

Li, Fusheng

Four key components with regards to Monte Carlo Library Least Squares (MCLLS) have been developed by the author. These include: a comprehensive and accurate Monte Carlo simulation code - CEARXRF5 with Differential Operators (DO) and coincidence sampling, Detector Response Function (DRF), an integrated Monte Carlo - Library Least-Squares (MCLLS) Graphical User Interface (GUI) visualization System (MCLLSPro) and a new reproducible and flexible benchmark experiment setup. All these developments or upgrades enable the MCLLS approach to be a useful and powerful tool for a tremendous variety of elemental analysis applications. CEARXRF, a comprehensive and accurate Monte Carlo code for simulating the total and individual library spectral responses of all elements, has been recently upgraded to version 5 by the author. The new version has several key improvements: input file format fully compatible with MCNP5, a new efficient general geometry tracking code, versatile source definitions, various variance reduction techniques (e.g. weight window mesh and splitting, stratifying sampling, etc.), a new cross section data storage and accessing method which improves the simulation speed by a factor of four and new cross section data, upgraded differential operators (DO) calculation capability, and also an updated coincidence sampling scheme which including K-L and L-L coincidence X-Rays, while keeping all the capabilities of the previous version. The new Differential Operators method is powerful for measurement sensitivity study and system optimization. For our Monte Carlo EDXRF elemental analysis system, it becomes an important technique for quantifying the matrix effect in near real time when combined with the MCLLS approach. An integrated visualization GUI system has been developed by the author to perform elemental analysis using iterated Library Least-Squares method for various samples when an initial guess is provided. This software was built on the Borland C++ Builder platform and has a user-friendly interface to accomplish all qualitative and quantitative tasks easily. That is to say, the software enables users to run the forward Monte Carlo simulation (if necessary) or use previously calculated Monte Carlo library spectra to obtain the sample elemental composition estimation within a minute. The GUI software is easy to use with user-friendly features and has the capability to accomplish all related tasks in a visualization environment. It can be a powerful tool for EDXRF analysts. A reproducible experiment setup has been built and experiments have been performed to benchmark the system. Two types of Standard Reference Materials (SRM), stainless steel samples from National Institute of Standards and Technology (NIST) and aluminum alloy samples from Alcoa Inc., with certified elemental compositions, are tested with this reproducible prototype system using a 109Cd radioisotope source (20mCi) and a liquid nitrogen cooled Si(Li) detector. The results show excellent agreement between the calculated sample compositions and their reference values and the approach is very fast.

MyGeoHub: A Collaborative Geospatial Research and Education Platform

NASA Astrophysics Data System (ADS)

Kalyanam, R.; Zhao, L.; Biehl, L. L.; Song, C. X.; Merwade, V.; Villoria, N.

2017-12-01

Scientific research is increasingly collaborative and globally distributed; research groups now rely on web-based scientific tools and data management systems to simplify their day-to-day collaborative workflows. However, such tools often lack seamless interfaces, requiring researchers to contend with manual data transfers, annotation and sharing. MyGeoHub is a web platform that supports out-of-the-box, seamless workflows involving data ingestion, metadata extraction, analysis, sharing and publication. MyGeoHub is built on the HUBzero cyberinfrastructure platform and adds general-purpose software building blocks (GABBs), for geospatial data management, visualization and analysis. A data management building block iData, processes geospatial files, extracting metadata for keyword and map-based search while enabling quick previews. iData is pervasive, allowing access through a web interface, scientific tools on MyGeoHub or even mobile field devices via a data service API. GABBs includes a Python map library as well as map widgets that in a few lines of code, generate complete geospatial visualization web interfaces for scientific tools. GABBs also includes powerful tools that can be used with no programming effort. The GeoBuilder tool provides an intuitive wizard for importing multi-variable, geo-located time series data (typical of sensor readings, GPS trackers) to build visualizations supporting data filtering and plotting. MyGeoHub has been used in tutorials at scientific conferences and educational activities for K-12 students. MyGeoHub is also constantly evolving; the recent addition of Jupyter and R Shiny notebook environments enable reproducible, richly interactive geospatial analyses and applications ranging from simple pre-processing to published tools. MyGeoHub is not a monolithic geospatial science gateway, instead it supports diverse needs ranging from just a feature-rich data management system, to complex scientific tools and workflows.

Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis.

PubMed

Smith, Toby; Pelpola, Kelum; Ball, Martin; Ong, Alice; Myint, Phyo Kyaw

2014-07-01

hip fracture is a common and serious condition associated with high mortality. This study aimed to identify pre-operative characteristics which are associated with an increased risk of mortality after hip fracture surgery. systematic search of published and unpublished literature databases, including EMBASE, MEDLINE, AMED, CINAHL, PubMed and the Cochrane Library, was undertaken to identify all clinical studies on pre-operative predictors of mortality after surgery in hip fracture with at least 3-month follow-up. Data pertaining to the study objectives was extracted by two reviewers independently. Where study homogeneity was evidence, a meta-analysis of pooled relative risk and 95% confidence intervals was performed for mortality against pre-admission characteristics. fifty-three studies including 544,733 participants were included. Thirteen characteristics were identified as possible pre-operative indicators for mortality. Following meta-analysis, the four key characteristics associated with the risk of mortality up to 12 months were abnormal ECG (RR: 2.00; 95% CI: 1.45, 2.76), cognitive impairment (RR: 1.91; 95% CI: 1.35, 2.70), age >85 years (RR: 0.42; 95% CI: 0.20, 0.90) and pre-fracture mobility (RR: 0.13; 95% CI: 0.05, 0.34). Other statistically significant pre-fracture predictors of increased mortality were male gender, being resident in a care institution, intra-capsular fracture type, high ASA grade and high Charlson comorbidity score on admission. this review has identified the characteristics of patients with a high risk of mortality after a hip fracture surgery beyond the peri-operative period who may benefit from comprehensive assessment and appropriate management. CRD42012002107. © The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Technical Assistance for the Conservation of Built Heritage at Bagan, Myanmar

NASA Astrophysics Data System (ADS)

Mezzino, D.; Santana Quintero, M.; Ma Pwint, P.; Tin Htut Latt, W.; Rellensmann, C.

2016-06-01

Presenting the outcomes of a capacity building activity, this contribution illustrates a replicable recording methodology to obtain timely, relevant and accurate information about conditions, materials and transformations of heritage structures. The purpose of the presented training activity consisted in developing local capabilities for the documentation of the built heritage at Bagan, Myanmar, employing different IT-supported techniques. Under the Director of UNESCO, the direct supervision of the chief of the culture unit, and in close consultation and cooperation with the Association of Myanmar Architects, the Department of Archaeology National Museum and Library (DoA) a documentation strategy has been developed in order to set up a recording methodology for the over three thousand Bagan monuments. The site, located in central Myanmar, in South East Asia, was developed between the IX and the XIII century as capital of the Myanmar kingdom. In the last years, this outstanding site has been exposed to an increasing number of natural hazards including earthquakes and flooding that strongly affected its built structures. Therefore, a documentation strategy to quickly capture shape, color, geometry and conditions of the monuments, in order to develop proper conservation projects, was needed. The scope of the training activity consisted in setting up a recording strategy updating the existing Bagan inventory, using three Buddhist temples as pilot cases study. The three documented temples were different in size, construction period, conditions and shape. The documentation included several IT-supported techniques including: Electronic Distance Measurements (EDM), SFM Photogrammetry, Laser Scanning, Record Photography as well as hand measurement and field notes. The monuments' surveying has been developed in accordance with the guidelines and standards established by the ICOMOS International Committee for Documentation of Cultural Heritage (CIPA). Recommendations on how to extend the adopted methodology to the other Bagan monuments have been also elaborated.

Design and Operation of the RHIC 80-K Cooler

NASA Astrophysics Data System (ADS)

Nicoletti, A.; Reuter, A.; Sidi-Yekhlef, A.; Talty, P.; Quimby, E.

2004-06-01

A stand-alone cryogenic system designed to maintain the magnets of the Relativistic Heavy Ion Collider (RHIC) at between 80 and 100 K during accelerator shutdown periods has been conceived and designed at Brookhaven National Laboratory and built by PHPK Technologies of Columbus, Ohio. Since most thermal contraction occurs above this temperature, this unit, referred to as the 80-K Cooler, will eliminate the stresses associated with thermal cycling. The cooling system will provide the necessary refrigeration by circulating cooled helium gas at approximately 1500 kPA through the RHIC heat shields and magnets. This helium is cooled by heat exchange with liquid nitrogen and circulated via three cold centrifugal pumps. The nominal delivered cooling capacity required to maintain the magnets at temperature is approximately 36 kW, primarily intercepted at the heat shield. The system also has separate heat exchangers for use as a pre-cooler from room temperature to 82 K. Selection of sextant or sextants for pre-cooling is designed into the RHIC cryogenic distribution system. Topics covered include Cooler design decisions, details of the Cooler as built, integration into the existing RHIC cryogenic system and initial operating experience.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Wei; Liu, Yang; Zu, Xiangyang

Highlights: {yields} Successfully selected specific PreS1-interacting peptides by using phage displayed library. {yields} Alignment of the positive phage clones revealed a consensus PreS1 binding motif. {yields} A highly enriched peptide named P7 had a strong binding ability for PreS1. {yields} P7 could block PreS1 attachment. -- Abstract: The PreS1 protein is present on the outermost part of the hepatitis B virus (HBV) surface and has been shown to have a pivotal function in viral infectivity and assembly. The development of reagents with high affinity and specificity for PreS1 is of great significance for early diagnosis and treatment of HBV infection.more » A phage display library of dodecapeptide was screened for interactions with purified PreS1 protein. Alignment of the positive phage clones revealed a putative consensus PreS1 binding motif of HX{sub n}HX{sub m}HP/R. Moreover, a peptide named P7 (KHMHWHPPALNT) was highly enriched and occurred with a surprisingly high frequency of 72%. A thermodynamic study revealed that P7 has a higher binding affinity to PreS1 than the other peptides. Furthermore, P7 was able to abrogate the binding of HBV virions to the PreS1 antibody, suggesting that P7 covers key functional sites on the native PreS1 protein. This newly isolated peptide may, therefore, be a new therapeutic candidate for the treatment of HBV. The consensus motif could be modified to deliver imaging, diagnostic, and therapeutic agents to tissues affected by HBV.« less

[Aged woman's vulnerability related to AIDS].

PubMed

Silva, Carla Marins; Lopes, Fernanda Maria do Valle Martins; Vargens, Octavio Muniz da Costa

2010-09-01

This article is a systhematic literature review including the period from 1994 to 2009, whose objective was to discuss the aged woman's vulnerability in relation to Acquired Imunodeficiency Syndrome (Aids). The search for scientific texts was accomplished in the following databases: Biblioteca Virtual em Saúde, Scientific Eletronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) and Medical Literature Analysis and Retrieval System Online (MEDLINE). The descriptors used were vulnerability, woman and Aids. Eighteen texts were analyzed, including articles in scientific journals, thesis and dissertations. As a conclusion, it was noted that aged women and vulnerability to Aids are directly related, through gender characteristics including submission and that were built historical and socially. We consider as fundamental the development of studies which may generate publications accessible to women, in order to help them see themselves as persons vulnerable to Aids contagion just for being women.

American-built hardware for ASPT undergoes pre-delivery preparations

NASA Image and Video Library

1974-09-11

S74-28295 (September 1974) --- American-built hardware for the joint U.S.-USSR Apollo-Soyuz Test Project mission undergoes pre-delivery preparations in the giant clean room at Rockwell International Corporation?s Space Division at Downey, California. The U.S. portion of the ASTP docking system is in the right foreground. In the right background is the cylindrical-shaped docking module, which is designed to link the Apollo and Soyuz spacecraft when they dock in Earth orbit next summer. In the left background is the Apollo Command Module which they will carry the three American astronauts into Earth orbit. Photo credit: NASA

a Webgis for the Knowledge and Conservation of the Historical Wall Structures of the 13TH-18TH Centuries

NASA Astrophysics Data System (ADS)

Vacca, G.; Pili, D.; Fiorino, D. R.; Pintus, V.

2017-05-01

The presented work is part of the research project, titled "Tecniche murarie tradizionali: conoscenza per la conservazione ed il miglioramento prestazionale" (Traditional building techniques: from knowledge to conservation and performance improvement), with the purpose of studying the building techniques of the 13th-18th centuries in the Sardinia Region (Italy) for their knowledge, conservation, and promotion. The end purpose of the entire study is to improve the performance of the examined structures. In particular, the task of the authors within the research project was to build a WebGIS to manage the data collected during the examination and study phases. This infrastructure was entirely built using Open Source software. The work consisted of designing a database built in PostgreSQL and its spatial extension PostGIS, which allows to store and manage feature geometries and spatial data. The data input is performed via a form built in HTML and PHP. The HTML part is based on Bootstrap, an open tools library for websites and web applications. The implementation of this template used both PHP and Javascript code. The PHP code manages the reading and writing of data to the database, using embedded SQL queries. As of today, we surveyed and archived more than 300 buildings, belonging to three main macro categories: fortification architectures, religious architectures, residential architectures. The masonry samples investigated in relation to the construction techniques are more than 150. The database is published on the Internet as a WebGIS built using the Leaflet Javascript open libraries, which allows creating map sites with background maps and navigation, input and query tools. This too uses an interaction of HTML, Javascript, PHP and SQL code.

14. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN Reach by foot ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN Reach by foot from E end of Vine St. St. Louis and San Francisco RR bridge. Bridge built 1887, replaced, 1969. Credit: Evans Memorial Library, Aberdeen, Ms. No date. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Columbus, Lowndes County, MS

The Pain in Storage: Work Safety in a High-Density Shelving Facility

ERIC Educational Resources Information Center

Atkins, Stephanie A.

2005-01-01

An increasing number of academic and research libraries have built high-density shelving facilities to address overcrowding conditions in their regular stacks. However, the work performed in these facilities is physically strenuous and highly repetitive in nature and may require the use of potentially dangerous equipment. This article will examine…

Point of View--Political Glitches

ERIC Educational Resources Information Center

Shaw, Robert

2004-01-01

Students in Mr. Shaw's classes used to be free to discover the joy of reading books of their own choosing. But that kind of spontaneity is vanishing under No Child Left Behind. This article describes the classroom library Mr. Shaw has built throughout the years and the joy it has brought to his students and their learning.

The Invention Factory: Thomas Edison's Laboratories. Teaching with Historic Places.

ERIC Educational Resources Information Center

Bolger, Benjamin

This lesson explores the group of buildings in West Orange, New Jersey, built in 1887, that formed the core of Thomas Edison's research and development complex. They consisted of chemistry, physics, and metallurgy laboratories; machine shop; pattern shop; research library; and rooms for experiments. The lesson explains that the prototypes (ideas…

Building of Causality: A Future for School Librarianship Research and Practice

ERIC Educational Resources Information Center

Mardis, Marcia A.; Kimmel, Sue C.; Pasquini, Laura A.

2018-01-01

The Colorado Study (Lance, Wellborn, and Hamilton-Pennell 1993) and its many replications in other states have demonstrated that when educators and learners had access to a qualified school librarian in the context of a thoughtfully built, adequately resourced, technology rich, and widely accessible school library, learners tended to flourish on…

A Tale of Two Cultures: Building Community by Researching Community

ERIC Educational Resources Information Center

Drane, Jon; Cai, Wenjie; Wechsler, Andrea; Mussi, Eveline; Shi, Ye; Crommelin, Laura

2012-01-01

Upon beginning postgraduate research at the Faculty of Built Environment at UNSW, the authors were surprised to find themselves working in a library-like environment, where a culture of silence prevailed. Assuming initially that this was just how postgraduate research was, they soon learned that the building also housed a second postgraduate lab…

Outline of Standards for Migration to Integrated Online System.

ERIC Educational Resources Information Center

Millen, Celeste; And Others

Intended to describe an ideal system for William Madison Randall Library at the University of North Carolina-Wilmington, this outline presents specific system requirements that would build on and enhance features available on the current system while moving toward a truly integrated system with built-in possibilities for expansion and improvements…

Integrating the Apache Big Data Stack with HPC for Big Data

NASA Astrophysics Data System (ADS)

Fox, G. C.; Qiu, J.; Jha, S.

2014-12-01

There is perhaps a broad consensus as to important issues in practical parallel computing as applied to large scale simulations; this is reflected in supercomputer architectures, algorithms, libraries, languages, compilers and best practice for application development. However, the same is not so true for data intensive computing, even though commercially clouds devote much more resources to data analytics than supercomputers devote to simulations. We look at a sample of over 50 big data applications to identify characteristics of data intensive applications and to deduce needed runtime and architectures. We suggest a big data version of the famous Berkeley dwarfs and NAS parallel benchmarks and use these to identify a few key classes of hardware/software architectures. Our analysis builds on combining HPC and ABDS the Apache big data software stack that is well used in modern cloud computing. Initial results on clouds and HPC systems are encouraging. We propose the development of SPIDAL - Scalable Parallel Interoperable Data Analytics Library -- built on system aand data abstractions suggested by the HPC-ABDS architecture. We discuss how it can be used in several application areas including Polar Science.

Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

PubMed

Schuster, Daniela; Nashev, Lyubomir G; Kirchmair, Johannes; Laggner, Christian; Wolber, Gerhard; Langer, Thierry; Odermatt, Alex

2008-07-24

17Beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) plays a pivotal role in the local synthesis of the most potent estrogen estradiol. Its expression is a prognostic marker for the outcome of patients with breast cancer and inhibition of 17beta-HSD1 is currently under consideration for breast cancer prevention and treatment. We aimed to identify nonsteroidal 17beta-HSD1 inhibitor scaffolds by virtual screening with pharmacophore models built from crystal structures containing steroidal compounds. The most promising model was validated by comparing predicted and experimentally determined inhibitory activities of several flavonoids. Subsequently, a virtual library of nonsteroidal compounds was screened against the 3D pharmacophore. Analysis of 14 selected compounds yielded four that inhibited the activity of human 17beta-HSD1 (IC 50 below 50 microM). Specificity assessment of identified 17beta-HSD1 inhibitors emphasized the importance of including related short-chain dehydrogenase/reductase (SDR) members to analyze off-target effects. Compound 29 displayed at least 10-fold selectivity over the related SDR enzymes tested.

Roof Type Selection Based on Patch-Based Classification Using Deep Learning for High Resolution Satellite Imagery

NASA Astrophysics Data System (ADS)

Partovi, T.; Fraundorfer, F.; Azimi, S.; Marmanis, D.; Reinartz, P.

2017-05-01

3D building reconstruction from remote sensing image data from satellites is still an active research topic and very valuable for 3D city modelling. The roof model is the most important component to reconstruct the Level of Details 2 (LoD2) for a building in 3D modelling. While the general solution for roof modelling relies on the detailed cues (such as lines, corners and planes) extracted from a Digital Surface Model (DSM), the correct detection of the roof type and its modelling can fail due to low quality of the DSM generated by dense stereo matching. To reduce dependencies of roof modelling on DSMs, the pansharpened satellite images as a rich resource of information are used in addition. In this paper, two strategies are employed for roof type classification. In the first one, building roof types are classified in a state-of-the-art supervised pre-trained convolutional neural network (CNN) framework. In the second strategy, deep features from deep layers of different pre-trained CNN model are extracted and then an RBF kernel using SVM is employed to classify the building roof type. Based on roof complexity of the scene, a roof library including seven types of roofs is defined. A new semi-automatic method is proposed to generate training and test patches of each roof type in the library. Using the pre-trained CNN model does not only decrease the computation time for training significantly but also increases the classification accuracy.

Pre-Hospital Emergency in Iran: A Systematic Review.

PubMed

Bahadori, Mohammadkarim; Ghardashi, Fatemeh; Izadi, Ahmad Reza; Ravangard, Ramin; Mirhashemi, Sedigheh; Hosseini, Seyed Mojtaba

2016-05-01

Pre-hospital care plays a vital role in saving trauma patients. This study aims to review studies conducted on the pre-hospital emergency status in Iran. Data were sourced from Iranian electronic databases, including SID, IranMedex, IranDoc, Magiran, and non-Iranian electronic databases, such as Medline, Embase, Cochrane Library, Scopus, and Google Scholar. In addition, available data and statistics for the country were used. All Persian-language articles published in Iranian scientific journals and related English-language articles published in Iranian and non-Iranian journals indexed on valid sites for September 2005 - 2014 were systematically reviewed. To review the selected articles, a data extraction form developed by the researchers as per the study's objective was adopted. The articles were examined under two categories: structure and function of pre-hospital emergency. A total of 19 articles were selected, including six descriptive studies (42%), four descriptive-analytical studies (21%), five review articles (16%), two qualitative studies (10.5%), and two interventional (experimental) studies (10.5%). In addition, of these, 14 articles (73.5%) had been published in the English language. The focus of these selected articles were experts (31.5%), bases of emergency medical services (26%), injured (16%), data reviews (16%), and employees (10.5%). A majority of the studies (68%) investigated pre-hospital emergency functions and 32% reviewed the pre-hospital emergency structure. The number of studies conducted on pre-hospital emergency services in Iran is limited. To promote public health, consideration of prevention areas, processes to provide pre-hospital emergency services, policymaking, foresight, systemic view, comprehensive research programs and roadmaps, and assessments of research needs in pre-hospital emergency seem necessary.

Management of pre-eclampsia: issues for anaesthetists.

PubMed

Dennis, A T

2012-09-01

Pre-eclampsia is a leading cause of maternal morbidity and mortality. Substandard care is often present and many deaths are preventable. The aim of this review is to summarise the key management issues for anaesthetists in the light of the current literature. A systematic literature search of electronic databases was undertaken including MEDLINE, EMBASE and the Cochrane Library using the key words obstetrics, pregnancy, pregnancy complications, maternal, pre-eclampsia, preeclampsia, cardiac function, haemodynamics, haemolysis, elevated liver enzymes, low platelets (HELLP), eclampsia, anaesthesia, anesthesia, neuraxial. Relevant Colleges and Societies websites were examined for pertinent guidelines. The disease is defined within the context of hypertensive diseases, and early recognition of pre-eclampsia and its complications, as well as multidisciplinary expert team management is highlighted. Accurate monitoring and recording of observations including the use of transthoracic echocardiography is discussed. The importance of the treatment of systolic blood pressure>180 mmHg and the use of intravenous antihypertensive medication as well as the use of parenteral magnesium sulphate for the treatment and prevention of eclampsia is emphasised . Restricted intravenous fluid therapy and avoidance of ergometrine is discussed. Neuraxial analgesia and anaesthesia, and general anaesthesia for birth is summarised as well as postpartum management including analgesia, thromboprophylaxis, management of acute pulmonary oedema and the use of pharmacological agents in the setting of breastfeeding. Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.

Digitization and the Creation of Virtual Libraries: The Princeton University Image Card Catalog--Reaping the Benefits of Imaging.

ERIC Educational Resources Information Center

Henthorne, Eileen

1995-01-01

Describes a project at the Princeton University libraries that converted the pre-1981 public card catalog, using digital imaging and optical character recognition technology, to fully tagged and indexed records of text in MARC format that are available on an online database and will be added to the online catalog. (LRW)

Building a Hypertextual Digital Library in the Humanities: A Case Study on London.

ERIC Educational Resources Information Center

Crane, Gregory; Smith, David A.; Wulfman, Clifford E.

This paper describes the creation of a new humanities digital library collection: 11,000,000 words and 10,000 images representing books, images, and maps on pre-twentieth century London and its environs. The London collection contained far more dense and precise information than the materials from the Greco-Roman world. The London collection thus…

Nanostructured Ti-Ta thin films synthesized by combinatorial glancing angle sputter deposition

NASA Astrophysics Data System (ADS)

Motemani, Yahya; Khare, Chinmay; Savan, Alan; Hans, Michael; Paulsen, Alexander; Frenzel, Jan; Somsen, Christoph; Mücklich, Frank; Eggeler, Gunther; Ludwig, Alfred

2016-12-01

Ti-Ta alloys are attractive materials for applications in actuators as well as biomedical implants. When fabricated as thin films, these alloys can potentially be employed as microactuators, components for micro-implantable devices and coatings on surgical implants. In this study, Ti100-x Ta x (x = 21, 30) nanocolumnar thin films are fabricated by glancing angle deposition (GLAD) at room temperature using Ti73Ta27 and Ta sputter targets. Crystal structure, morphology and microstructure of the nanostructured thin films are systematically investigated by XRD, SEM and TEM, respectively. Nanocolumns of ˜150-160 nm in width are oriented perpendicular to the substrate for both Ti79Ta21 and Ti70Ta30 compositions. The disordered α″ martensite phase with orthorhombic structure is formed in room temperature as-deposited thin films. The columns are found to be elongated small single crystals which are aligned perpendicular to the (20\\bar{4}) and (204) planes of α″ martensite, indicating that the films’ growth orientation is mainly dominated by these crystallographic planes. Laser pre-patterned substrates are utilized to obtain periodic nanocolumnar arrays. The differences in seed pattern, and inter-seed distances lead to growth of multi-level porous nanostructures. Using a unique sputter deposition geometry consisting of Ti73Ta27 and Ta sputter sources, a nanocolumnar Ti-Ta materials library was fabricated on a static substrate by a co-deposition process (combinatorial-GLAD approach). In this library, a composition spread developed between Ti72.8Ta27.2 and Ti64.4Ta35.6, as confirmed by high-throughput EDX analysis. The morphology over the materials library varies from well-isolated nanocolumns to fan-like nanocolumnar structures. The influence of two sputter sources is investigated by studying the resulting column angle on the materials library. The presented nanostructuring methods including the use of the GLAD technique along with pre-patterning and a combinatorial materials library fabrication strategy offer a promising technological approach for investigating Ti-Ta thin films for a range of applications. The proposed approaches can be similarly implemented for other materials systems which can benefit from the formation of a nanocolumnar morphology.

Introducing a New Software for Geodetic Analysis

NASA Astrophysics Data System (ADS)

Hjelle, G. A.; Dähnn, M.; Fausk, I.; Kirkvik, A. S.; Mysen, E.

2016-12-01

At the Norwegian Mapping Authority, we are currently developing Where, a newsoftware for geodetic analysis. Where is built on our experiences with theGeosat software, and will be able to analyse and combine data from VLBI, SLR,GNSS and DORIS. The software is mainly written in Python which has proved veryfruitful. The code is quick to write and the architecture is easily extendableand maintainable. The Python community provides a rich eco-system of tools fordoing data-analysis, including effective data storage and powerfulvisualization. Python interfaces well with other languages so that we can easilyreuse existing, well-tested code like the SOFA and IERS libraries. This presentation will show some of the current capabilities of Where,including benchmarks against other software packages. In addition we will reporton some simple investigations we have done using the software, and outline ourplans for further progress.

MHOST: An efficient finite element program for inelastic analysis of solids and structures

NASA Technical Reports Server (NTRS)

Nakazawa, S.

1988-01-01

An efficient finite element program for 3-D inelastic analysis of gas turbine hot section components was constructed and validated. A novel mixed iterative solution strategy is derived from the augmented Hu-Washizu variational principle in order to nodally interpolate coordinates, displacements, deformation, strains, stresses and material properties. A series of increasingly sophisticated material models incorporated in MHOST include elasticity, secant plasticity, infinitesimal and finite deformation plasticity, creep and unified viscoplastic constitutive model proposed by Walker. A library of high performance elements is built into this computer program utilizing the concepts of selective reduced integrations and independent strain interpolations. A family of efficient solution algorithms is implemented in MHOST for linear and nonlinear equation solution including the classical Newton-Raphson, modified, quasi and secant Newton methods with optional line search and the conjugate gradient method.

The NITON{reg_sign} XL-800 Series Multi-Element Spectrum Analyzer (Alloy Analyzer). Innovative Technology Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2000-04-01

The NITON{reg_sign} 800 series analyzer is a hand-held, battery operated unit that measures 8-in x 3-in x 2-in and weighs 2.5 pounds. The analyzer uses x-ray fluorescence spectrum analysis to identify and quantify elements in metal and then compares the readings to a built-in library to determine a metal's alloy. The library contains 300 elements and alloys, and can be customized to identify other elements and alloys (depending on the sources in the instrument). The basic unit utilizes a Cadmium-109 source, but each analyzer unit can hold up to two sources. These sources include Iron-55 and Americium-241. Pushing a safetymore » button located on the side of the unit and placing it against a surface opens the shutter window. Within seconds the unit beeps, and displays the results. The analyzer stores up to 1,000 data sets, including sample identification codes using a barcode reader. The data is easily downloaded to a conventional computer when sampling has been completed. Batteries are good for 8-hrs and charge in less than 2 hours and it can be carried, shipped, or transported without exterior labeling, conforming to 49 CFR 143.421.« less

RF wave simulation for cold edge plasmas using the MFEM library

NASA Astrophysics Data System (ADS)

Shiraiwa, S.; Wright, J. C.; Bonoli, P. T.; Kolev, T.; Stowell, M.

2017-10-01

A newly developed generic electro-magnetic (EM) simulation tool for modeling RF wave propagation in SOL plasmas is presented. The primary motivation of this development is to extend the domain partitioning approach for incorporating arbitrarily shaped SOL plasmas and antenna to the TORIC core ICRF solver, which was previously demonstrated in the 2D geometry [S. Shiraiwa, et. al., "HISTORIC: extending core ICRF wave simulation to include realistic SOL plasmas", Nucl. Fusion in press], to larger and more complicated simulations by including a 3D realistic antenna and integrating RF rectified sheath potential model. Such an extension requires a scalable high fidelity 3D edge plasma wave simulation. We used the MFEM [http://mfem.org], open source scalable C++ finite element method library, and developed a Python wrapper for MFEM (PyMFEM), and then a radio frequency (RF) wave physics module in Python. This approach allows for building a physics layer rapidly, while separating the physics implementation being apart from the numerical FEM implementation. An interactive modeling interface was built on pScope [S Shiraiwa, et. al. Fusion Eng. Des. 112, 835] to work with an RF simulation model in a complicated geometry.

A universal phage display system for the seamless construction of Fab libraries.

PubMed

Nelson, Renae S; Valadon, Philippe

2017-11-01

The construction of Fab phage libraries requires the cloning of domains from both the light and the heavy chain of antibodies. Despite the advent of powerful strategies such as splicing-by-overlap extension PCR, obtaining high quality libraries with excellent coverage remains challenging. Here, we explored the use of type IIS restriction enzymes for the seamless cloning of Fab libraries. We analyzed human, murine and rabbit germline antibody repertoires and identified combinations of restriction enzymes that exhibit very few or no recognition sites in the antibody sequences. We describe three phagemid vectors, pUP-22Hb, pUP-22Mc and pUP-22Rc, which were employed for cloning the Fab repertoire of these hosts using BsmBI and SapI (human) or SapI alone (mouse and rabbit). Using human serum albumin as a model immunization, we built a mouse/human chimeric Fab library and a mouse Fab library in a single step ligation and successfully panned multiple cognate antibodies. The overall process is highly scalable and faster than PCR-based techniques, with a Fab insertion success rate of around 80%. By using carefully chosen overhangs on each end of the antibody domains, this approach paves the way to the universal, sequence- and vector-independent cloning and reformatting of antibody libraries. Copyright © 2017 Elsevier B.V. All rights reserved.

Mechanical integrity and sustainability of pre-stressed concrete bridge girders repaired by epoxy injection – phase 1.

DOT National Transportation Integrated Search

2017-02-02

At present, there is a need to assess the mechanical integrity and sustainability of pre-stressed concrete beams during the entire life cycle of the built infrastructure. According to the NCHRP (Tadros et al., 2010), further research to develop fi...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koning, A.J.; Bersillon, O.; Forrest, R. A.

The status of the Joint Evaluated Fission and Fusion file (JEFF) is described. The next version of the library, JEFF-3.1, comprises a significant update of actinide evaluations, evaluations emerging from European nuclear data projects, the activation library JEFF-3/A, the decay data and fission yield library, and fusion-related data files from the EFF project. The revisions were motivated by the availability of new measurements, modelling capabilities, or trends from integral experiments. Various pre-release validation efforts are underway, mainly for criticality and shielding of thermal and fast systems. This JEFF-3.1 library is expected to provide improved performances with respect to previous releasesmore » for a variety of scientific and industrial applications.« less

Pre-pregnancy care for women with pre-gestational diabetes mellitus: a systematic review and meta-analysis

PubMed Central

2012-01-01

Background Pre-gestational diabetes mellitus is associated with increased risk for maternal and fetal adverse outcomes. This systematic review was carried out to evaluate the effectiveness and safety of pre-pregnancy care in improving the rate of congenital malformations and perinatal mortality for women with pre-gestational diabetes mellitus. Methods We searched the following databases, MEDLINE, EMBASE, WEB OF SCIENCE, Cochrane Library, including the CENTRAL register of controlled trials and CINHAL up to December 2011, without language restriction, for any pre-pregnancy care aiming at health promotion, glycemic control and screening and treatment of diabetes complications in women with type I or type II diabetes mellitus. Study design were trials (randomized and non-randomized), cohort and case–control studies. Results Of the 2452 title scanned 54 full papers were retrieved of those 21 studies were included in this review. Twelve cohort studies at low and medium risk of bias, with 3088 women, were included in the meta-analysis. Meta-analysis suggested that pre-pregnancy care is effective in reducing congenital malformation, Risk Ratio (RR) 0.25 (95% CI 0.16-0.37), number needed to treat (NNT) 19 (95% CI 14–24), and perinatal mortality RR 0.34 (95% CI 0.15-0.75), NNT = 46 (95% CI 28–115). Pre-pregnancy care lowers glycosylated hemoglobin A1c (HbA1c) in the first trimester of pregnancy by an average of 1.92% (95% CI −2.05 to −1.79). However women who received pre-pregnancy care were at increased risk of hypoglycemia during the first trimester of pregnancy RR 1.51 (95% CI 1.15-1.99). Conclusion Pre-pregnancy care for women with pre-gestational type 1 or type 2 diabetes mellitus is effective in improving rates of congenital malformations, perinatal mortality and in reducing maternal HbA1C in the first trimester of pregnancy. Pre-pregnancy care might cause maternal hypoglycemia in the first trimester of pregnancy. PMID:22978747

Evaluating a Pre-Session Homework Exercise in a Standalone Information Literacy Class

ERIC Educational Resources Information Center

Goetz, Joseph E.; Barber, Catherine R.

2015-01-01

In this study, researchers evaluate a homework exercise assigned before a standalone information literacy session. Students in a Master of Education program completed a worksheet using the ERIC database thesaurus. The researchers conducted pre- and posttests within a single library session to assess student learning, using a control group for…

The Role of Mentoring in the Leadership Development of Pre-Service School Librarians

ERIC Educational Resources Information Center

Smith, Daniella L.

2013-01-01

The purpose of this study was to determine how providing pre-service school librarians with mentors during their degree program impacted their level of self-perceived transformational leadership potential. The study consisted of 30 participants enrolled in a school library certification master's degree program emphasizing leadership. The findings…

Comparing published scientific journal articles to their pre-print versions

DOE PAGES

Klein, Martin; Broadwell, Peter; Farb, Sharon E.; ...

2018-02-05

Academic publishers claim that they add value to scholarly communications by coordinating reviews and contributing and enhancing text during publication. These contributions come at a considerable cost: US academic libraries paid $1.7 billion for serial subscriptions in 2008 alone. Library budgets, in contrast, are flat and not able to keep pace with serial price inflation. Here, we have investigated the publishers’ value proposition by conducting a comparative study of pre-print papers from two distinct science, technology, and medicine corpora and their final published counterparts. This comparison had two working assumptions: (1) If the publishers’ argument is valid, the text ofmore » a pre-print paper should vary measurably from its corresponding final published version, and (2) by applying standard similarity measures, we should be able to detect and quantify such differences. Our analysis revealed that the text contents of the scientific papers generally changed very little from their pre-print to final published versions. These findings contribute empirical indicators to discussions of the added value of commercial publishers and therefore should influence libraries’ economic decisions regarding access to scholarly publications.« less

Comparing published scientific journal articles to their pre-print versions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, Martin; Broadwell, Peter; Farb, Sharon E.

Academic publishers claim that they add value to scholarly communications by coordinating reviews and contributing and enhancing text during publication. These contributions come at a considerable cost: US academic libraries paid $1.7 billion for serial subscriptions in 2008 alone. Library budgets, in contrast, are flat and not able to keep pace with serial price inflation. Here, we have investigated the publishers’ value proposition by conducting a comparative study of pre-print papers from two distinct science, technology, and medicine corpora and their final published counterparts. This comparison had two working assumptions: (1) If the publishers’ argument is valid, the text ofmore » a pre-print paper should vary measurably from its corresponding final published version, and (2) by applying standard similarity measures, we should be able to detect and quantify such differences. Our analysis revealed that the text contents of the scientific papers generally changed very little from their pre-print to final published versions. These findings contribute empirical indicators to discussions of the added value of commercial publishers and therefore should influence libraries’ economic decisions regarding access to scholarly publications.« less

The Word ("Qara'a") (Read) in the Holy Koran and Pre-Islamic Poetry

ERIC Educational Resources Information Center

Al Deeky, Mahmoud

2016-01-01

This research deals with the verb "qara'a" (read) and with what is derived from or built on in Qur'an and pre Islam poetry. The research stems from the assumption that this item (read) did not appear in pre-Islam Arabic in the meaning agreed upon regarding the concept of reading a written text, and what is stated in the Qur'an regarding…

Case study: the Health SmartLibrary* experiences in web personalization and customization at the Galter Health Sciences Library, Northwestern University

PubMed Central

Shedlock, James; Frisque, Michelle; Hunt, Steve; Walton, Linda; Handler, Jonathan; Gillam, Michael

2010-01-01

Question: How can the user's access to health information, especially full-text articles, be improved? The solution is building and evaluating the Health SmartLibrary (HSL). Setting: The setting is the Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University. Method: The HSL was built on web-based personalization and customization tools: My E-Resources, Stay Current, Quick Search, and File Cabinet. Personalization and customization data were tracked to show user activity with these value-added, online services. Main Results: Registration data indicated that users were receptive to personalized resource selection and that the automated application of specialty-based, personalized HSLs was more frequently adopted than manual customization by users. Those who did customize customized My E-Resources and Stay Current more often than Quick Search and File Cabinet. Most of those who customized did so only once. Conclusion: Users did not always take advantage of the services designed to aid their library research experiences. When personalization is available at registration, users readily accepted it. Customization tools were used less frequently; however, more research is needed to determine why this was the case. PMID:20428276

The Data Conservancy

NASA Astrophysics Data System (ADS)

Choudhury, S.; Duerr, R. E.

2009-12-01

NSF's Sustainable Digital Data Preservation and Access Network Partners program is an ambitious attempt to integrate a wide variety of expertise and infrastructure into a network for providing "reliable digital preservation, access, integration, and analysis capabilities for science." One of the first two DataNet award recipients, the Data Conservancy, is itself a network of widely diverse partners led by the libraries at the Johns Hopkins University. The Data Conservancy is built on existing exemplar scientific projects, communities, and virtual organizations that have deep engagement with their user communities, and extensive experience with large-scale distributed system development. Data Conservancy members embrace a shared vision that data curation is not an end, but rather a means to collect, organize, validate, and preserve data needed to address the grand research challenges that face society. Data Conservancy members holdings encompass the entire range of earth, life, and space science data. New to the Data Conservancy is the concept that University libraries will be part of the distributed network of data centers and that data science will become a path in the library and information science curricula. As noted by Winston Tabb (JHU Dean of Libraries) "Data Centers are the new library stacks."

Monetary benefits of preventing childhood lead poisoning with lead-safe window replacement.

PubMed

Nevin, Rick; Jacobs, David E; Berg, Michael; Cohen, Jonathan

2008-03-01

Previous estimates of childhood lead poisoning prevention benefits have quantified the present value of some health benefits, but not the costs of lead paint hazard control or the benefits associated with housing and energy markets. Because older housing with lead paint constitutes the main exposure source today in the US, we quantify health benefits, costs, market value benefits, energy savings, and net economic benefits of lead-safe window replacement (which includes paint stabilization and other measures). The benefit per resident child from improved lifetime earnings alone is $21,195 in pre-1940 housing and $8685 in 1940-59 housing (in 2005 dollars). Annual energy savings are $130-486 per housing unit, with or without young resident children, with an associated increase in housing market value of $5900-14,300 per housing unit, depending on home size and number of windows replaced. Net benefits are $4490-5,629 for each housing unit built before 1940, and $491-1629 for each unit built from 1940-1959, depending on home size and number of windows replaced. Lead-safe window replacement in all pre-1960 US housing would yield net benefits of at least $67 billion, which does not include many other benefits. These other benefits, which are shown in this paper, include avoided Attention Deficit Hyperactivity Disorder, other medical costs of childhood lead exposure, avoided special education, and reduced crime and juvenile delinquency in later life. In addition, such a window replacement effort would reduce peak demand for electricity, carbon emissions from power plants, and associated long-term costs of climate change.

NOAA Photo Library - NOAA People - Portraits in Time Collection

Science.gov Websites

Collections page. Takes you to the search page. Takes you to the Links page. NOAA People - Portraits in Time Collage of NOAA People Organizations are built by individuals. An organization is the sum total of the view ALL current images. NOAA People Portraits in Time ~ Albums Coast surveyors in tent Coast &

Homesteading on the Web: The Queensland Department of Education Virtual Library.

ERIC Educational Resources Information Center

Cram, Jennifer; Allison, Myrl

1996-01-01

The Queensland Department of Education (Australia) developed a homesteading model as an alternative to the urban-built environment model of large multi-purpose networks. This resulted in the in-house development of a low-cost, stand-alone server and homepage. The charette technique was used to plan and design the Queensland Department of Education…

Should You? May You? Can You? Factors in Selecting Rare Books and Special Collections for Digitization

ERIC Educational Resources Information Center

Gertz, Janet

2013-01-01

Selection for digitization is about more than which items to scan. Selection is what shapes the online collections that are built by libraries, archives, historical societies, and other cultural heritage institutions. By selecting well, institutions can concentrate on the parts of their collections that are best suited to digitization, that make…

Characteristics and use of urban health indicator tools by municipal built environment policy and decision-makers: a systematic review protocol.

PubMed

Pineo, Helen; Glonti, Ketevan; Rutter, Harry; Zimmermann, Nicole; Wilkinson, Paul; Davies, Michael

2017-01-13

There is wide agreement that there is a lack of attention to health in municipal environmental policy-making, such as urban planning and regeneration. Explanations for this include differing professional norms between health and urban environment professionals, system complexity and limited evidence for causality between attributes of the built environment and health outcomes. Data from urban health indicator (UHI) tools are potentially a valuable form of evidence for local government policy and decision-makers. Although many UHI tools have been specifically developed to inform policy, there is poor understanding of how they are used. This study aims to identify the nature and characteristics of UHI tools and their use by municipal built environment policy and decision-makers. Health and social sciences databases (ASSIA, Campbell Library, EMBASE, MEDLINE, Scopus, Social Policy and Practice and Web of Science Core Collection) will be searched for studies using UHI tools alongside hand-searching of key journals and citation searches of included studies. Advanced searches of practitioner websites and Google will also be used to find grey literature. Search results will be screened for UHI tools, and for studies which report on or evaluate the use of such tools. Data about UHI tools will be extracted to compile a census and taxonomy of existing tools based on their specific characteristics and purpose. In addition, qualitative and quantitative studies about the use of these tools will be appraised using quality appraisal tools produced by the UK National Institute for Health and Care Excellence (NICE) and synthesised in order to gain insight into the perceptions, value and use of UHI tools in the municipal built environment policy and decision-making process. This review is not registered with PROSPERO. This systematic review focuses specifically on UHI tools that assess the physical environment's impact on health (such as transport, housing, air quality and greenspace). This study will help indicator producers understand whether this form of evidence is of value to built environment policy and decision-makers and how such tools should be tailored for this audience. N/A.

77 FR 32629 - Black Canyon Hydro, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... be viewed on the Web at http://www.ferc.gov , using the ``eLibrary'' link. Follow the directions for... review at the Commission in the Public Reference Room or may be viewed on the Commission's Web site ( http://www.ferc.gov ), using the ``eLibrary'' link. Enter the docket number, excluding the last three...

Effects of a Mathematics Intervention Program on the Computational Skills and Attitudes of Preservice Elementary and Secondary Teachers.

ERIC Educational Resources Information Center

Amodeo, Luiza B.; Emslie, Julia Rosa

Mathematics anxiety and competence of 57 Anglo and Hispanic pre-service teachers were measured before and after a 30-hour workshop using the training program EQUALS. Students were divided into three groups: elementary, secondary, and library media. Students in the library media class served as the control group; the other two groups were the…

Decide now, pay later: Early influences in math and science education

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malcom, S.

1995-12-31

Who are the people deciding to major in science, math or engineering in college? The early interest in science and math education which can lead to science and engineering careers, is shaped as much by the encompassing world of the child as it is by formal education experiences. This paper documents what we know and what we need to know about the influences on children from pre-kindergarten through sixth grade, including the home, pre-school groups, science and math programs in churches, community groups, the media, cultural institutions (museums, zoos, botanical gardens), libraries, and schools (curriculum, instruction, policies and assessment). Itmore » also covers the nature and quality of curricular and intervention programs, and identifies strategies that appear to be most effective for various groups.« less

Automatic Modeling and Simulation of Modular Robots

NASA Astrophysics Data System (ADS)

Jiang, C.; Wei, H.; Zhang, Y.

2018-03-01

The ability of reconfiguration makes modular robots have the ability of adaptable, low-cost, self-healing and fault-tolerant. It can also be applied to a variety of mission situations. In this manuscript, a robot platform which relied on the module library was designed, based on the screw theory and module theory. Then, the configuration design method of the modular robot was proposed. And the different configurations of modular robot system have been built, including industrial mechanical arms, the mobile platform, six-legged robot and 3D exoskeleton manipulator. Finally, the simulation and verification of one system among them have been made, using the analyses of screw kinematics and polynomial planning. The results of experiments demonstrate the feasibility and superiority of this modular system.

Introducing a New Software for Geodetic Analysis

NASA Astrophysics Data System (ADS)

Hjelle, Geir Arne; Dähnn, Michael; Fausk, Ingrid; Kirkvik, Ann-Silje; Mysen, Eirik

2017-04-01

At the Norwegian Mapping Authority, we are currently developing Where, a new software for geodetic analysis. Where is built on our experiences with the Geosat software, and will be able to analyse and combine data from VLBI, SLR, GNSS and DORIS. The software is mainly written in Python which has proved very fruitful. The code is quick to write and the architecture is easily extendable and maintainable, while at the same time taking advantage of well-tested code like the SOFA and IERS libraries. This presentation will show some of the current capabilities of Where, including benchmarks against other software packages, and outline our plans for further progress. In addition we will report on some investigations we have done experimenting with alternative weighting strategies for VLBI.

Robust Wave-front Correction in a Small Scale Adaptive Optics System Using a Membrane Deformable Mirror

NASA Astrophysics Data System (ADS)

Choi, Y.; Park, S.; Baik, S.; Jung, J.; Lee, S.; Yoo, J.

A small scale laboratory adaptive optics system using a Shack-Hartmann wave-front sensor (WFS) and a membrane deformable mirror (DM) has been built for robust image acquisition. In this study, an adaptive limited control technique is adopted to maintain the long-term correction stability of an adaptive optics system. To prevent the waste of dynamic correction range for correcting small residual wave-front distortions which are inefficient to correct, the built system tries to limit wave-front correction when a similar small difference wave-front pattern is repeatedly generated. Also, the effect of mechanical distortion in an adaptive optics system is studied and a pre-recognition method for the distortion is devised to prevent low-performance system operation. A confirmation process for a balanced work assignment among deformable mirror (DM) actuators is adopted for the pre-recognition. The corrected experimental results obtained by using a built small scale adaptive optics system are described in this paper.

Boston University Pre-Majors Program (BU Pre-Map): Promoting Diversity through First-Year Undergraduate Research

NASA Astrophysics Data System (ADS)

West, Andrew A.

2014-06-01

One of largest points of attrition for underrepresented minorities in STEM fields is the transition from high school to college. A report from Building Engineering and Science Talent (BEST) demonstrates that underrepresented minorities begin college interested in STEM fields at rates equal to (if nor slightly above) their representation in both college and the population (25%). However, by the time they graduate, underrepresented minorities make up only 15% of STEM majors and only 9% of the STEM advanced degrees. Most of the attrition occurs during the first year of college, when large classes, a lack of mentors and challenging courses lead many students (from all backgrounds) to consider other majors.In 2011 I started the Boston University Pre-Majors Program (or BU Pre-MaP), which is modeled after the University of Washington Pre-Majors in Astronomy Program (UW Pre-MAP), a program for recruiting, mentoring and training underrepresented, first-year introductory astronomy students (and of which I was an architect). As a significant part of the Pre-MAP (or Pre-MaP) model, first-year students are engaged in a research project with a faculty or grad-student mentor and learn many of the skills needed to be successful in science.The BU Pre-MaP uses weekly seminars to introduce students to BU and the college environment, discuss ways to be successful in and out of the classroom, highlights the importance of peer mentoring and cohort building and serves as a mechanism to introduce first-year students to research skills. In teams of two, the Pre-MaP students select (with assistance) a research mentor and work with him/her on a original research project.In addition, Pre-MaP students attend several field trips including (but not limited to) viewing original science documents at the Boston Public Library (including a first edition Copernicus) and an observing run at Lowell Observatory in Arizona.

Boston University Pre-Majors Program (BU Pre-Map): Promoting Diversity through First-Year Undergraduate Research

NASA Astrophysics Data System (ADS)

West, Andrew A.

2015-01-01

One of largest points of attrition for underrepresented minorities in STEM fields is the transition from high school to college. A report from Building Engineering and Science Talent (BEST) demonstrates that underrepresented minorities begin college interested in STEM fields at rates equal to (if nor slightly above) their representation in both college and the population (25%). However, by the time they graduate, underrepresented minorities make up only 15% of STEM majors and only 9% of the STEM advanced degrees. Most of the attrition occurs during the first year of college, when large classes, a lack of mentors and challenging courses lead many students (from all backgrounds) to consider other majors.In 2012 I started the Boston University Pre-Majors Program (or BU Pre-MaP), which is modeled after the University of Washington Pre-Majors in Astronomy Program (UW Pre-MAP), a program for recruiting, mentoring and training underrepresented, first-year introductory astronomy students (and of which I was an architect). As a significant part of the Pre-MAP (or Pre-MaP) model, first-year students are engaged in a research project with a faculty or grad-student mentor and learn many of the skills needed to be successful in science.The BU Pre-MaP uses weekly seminars to introduce students to BU and the college environment, discuss ways to be successful in and out of the classroom, highlights the importance of peer mentoring and cohort building and serves as a mechanism to introduce first-year students to research skills. In teams of two, the Pre-MaP students select (with assistance) a research mentor and work with him/her on a original research project.In addition, Pre-MaP students attend several field trips including (but not limited to) viewing original science documents at the Boston Public Library (including a first edition Copernicus) and an observing run at Lowell Observatory in Arizona.

Programming of a flexible computer simulation to visualize pharmacokinetic-pharmacodynamic models.

PubMed

Lötsch, J; Kobal, G; Geisslinger, G

2004-01-01

Teaching pharmacokinetic-pharmacodynamic (PK/PD) models can be made more effective using computer simulations. We propose the programming of educational PK or PK/PD computer simulations as an alternative to the use of pre-built simulation software. This approach has the advantage of adaptability to non-standard or complicated PK or PK/PD models. Simplicity of the programming procedure was achieved by selecting the LabVIEW programming environment. An intuitive user interface to visualize the time courses of drug concentrations or effects can be obtained with pre-built elements. The environment uses a wiring analogy that resembles electrical circuit diagrams rather than abstract programming code. The goal of high interactivity of the simulation was attained by allowing the program to run in continuously repeating loops. This makes the program behave flexibly to the user input. The programming is described with the aid of a 2-compartment PK simulation. Examples of more sophisticated simulation programs are also given where the PK/PD simulation shows drug input, concentrations in plasma, and at effect site and the effects themselves as a function of time. A multi-compartmental model of morphine, including metabolite kinetics and effects is also included. The programs are available for download from the World Wide Web at http:// www. klinik.uni-frankfurt.de/zpharm/klin/ PKPDsimulation/content.html. For pharmacokineticists who only program occasionally, there is the possibility of building the computer simulation, together with the flexible interactive simulation algorithm for clinical pharmacological teaching in the field of PK/PD models.

Flexible CRISPR library construction using parallel oligonucleotide retrieval

PubMed Central

Read, Abigail; Gao, Shaojian; Batchelor, Eric

2017-01-01

Abstract CRISPR/Cas9-based gene knockout libraries have emerged as a powerful tool for functional screens. We present here a set of pre-designed human and mouse sgRNA sequences that are optimized for both high on-target potency and low off-target effect. To maximize the chance of target gene inactivation, sgRNAs were curated to target both 5΄ constitutive exons and exons that encode conserved protein domains. We describe here a robust and cost-effective method to construct multiple small sized CRISPR library from a single oligo pool generated by array synthesis using parallel oligonucleotide retrieval. Together, these resources provide a convenient means for individual labs to generate customized CRISPR libraries of variable size and coverage depth for functional genomics application. PMID:28334828

CBCT-guided evolutive library for cervical adaptive IMRT.

PubMed

Rigaud, Bastien; Simon, Antoine; Gobeli, Maxime; Lafond, Caroline; Leseur, Julie; Barateau, Anais; Jaksic, Nicolas; Castelli, Joël; Williaume, Danièle; Haigron, Pascal; De Crevoisier, Renaud

2018-04-01

In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs [with empty (EB), intermediate (IB), and full (FB) bladder volumes], a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed. Five RT strategies were simulated for each patient: "Standard RT" was based on one IB planning CT; "internal target volume (ITV)-based RT" was an ITV built from the three planning CTs; "RT with one mid-treatment replanning (MidTtReplan)" corresponded to the standard RT with a replanning at 20 Gy; "Pretreatment library ART" using a planning library based on the three planning CTs; and the "Evolutive library ART", which was the "Pretreatment library ART" strategy enriched by including some CBCT anatomies into the library when the daily clinical target volume (CTV) shape differed from the ones in the library. Two planning target volume (PTV) margins of 7 and 10 mm were evaluated. All the strategies were geometrically compared in terms of the percentage of coverage by the PTV, for the CTV and the organs at risk (OAR) delineated on the CBCT. Inadequate coverage of the CTV and OARs by the PTV was also assessed using deformable image registration. The cumulated dose distributions of each strategy were likewise estimated and compared for one patient. The "Evolutive library ART" strategy involved a number of added CBCTs: 0 for 55%; 1 for 30%; 2 for 5%; and 3 for 10% of patients. Compared with the other four, this strategy provided the highest CTV geometric coverage by the PTV, with a mean (min-max) coverage of 98.5% (96.4-100) for 10 mm margins and 96.2% (93.0-99.7) for 7 mm margins (P < 0.05). Moreover, this strategy significantly decreased the geometric coverage of the bowel. CTV undercoverage by PTV occurred in the anterior and superior uterine regions for all strategies. The dosimetric analysis at 7 mm similarly demonstrated that the "Evolutive library ART" increased the V 42.75Gy of the CTV by 27%, 20%, 13%, and 28% compared with "Standard RT", "ITV-based RT", "MidTtReplan", and "Pretreatment library ART", respectively. The dose to the bowel was also decreased by the "Evolutive library ART" compared with that by the other strategies. The "Evolutive library ART" is a personalized ART strategy that comprises a pretreatment planning library of three CT scans, enriched for half of the patients by one to three per-treatment CBCTs. This original strategy increased both the CTV coverage and bowel sparing compared with all the other tested strategies and enables us to consider a PTV margin reduction. © 2018 American Association of Physicists in Medicine.

EarthCube GeoLink: Semantics and Linked Data for the Geosciences

NASA Astrophysics Data System (ADS)

Arko, R. A.; Carbotte, S. M.; Chandler, C. L.; Cheatham, M.; Fils, D.; Hitzler, P.; Janowicz, K.; Ji, P.; Jones, M. B.; Krisnadhi, A.; Lehnert, K. A.; Mickle, A.; Narock, T.; O'Brien, M.; Raymond, L. M.; Schildhauer, M.; Shepherd, A.; Wiebe, P. H.

2015-12-01

The NSF EarthCube initiative is building next-generation cyberinfrastructure to aid geoscientists in collecting, accessing, analyzing, sharing, and visualizing their data and knowledge. The EarthCube GeoLink Building Block project focuses on a specific set of software protocols and vocabularies, often characterized as the Semantic Web and "Linked Data", to publish data online in a way that is easily discoverable, accessible, and interoperable. GeoLink brings together specialists from the computer science, geoscience, and library science domains, and includes data from a network of NSF-funded repositories that support scientific studies in marine geology, marine ecosystems, biogeochemistry, and paleoclimatology. We are working collaboratively with closely-related Building Block projects including EarthCollab and CINERGI, and solicit feedback from RCN projects including Cyberinfrastructure for Paleogeosciences (C4P) and iSamples. GeoLink has developed a modular ontology that describes essential geoscience research concepts; published data from seven collections (to date) on the Web as geospatially-enabled Linked Data using this ontology; matched and mapped data between collections using shared identifiers for investigators, repositories, datasets, funding awards, platforms, research cruises, physical specimens, and gazetteer features; and aggregated the results in a shared knowledgebase that can be queried via a standard SPARQL endpoint. Client applications have been built around the knowledgebase, including a Web/map-based data browser using the Leaflet JavaScript library and a simple query service using the OpenSearch format. Future development will include extending and refining the GeoLink ontology, adding content from additional repositories, developing semi-automated algorithms to enhance metadata, and further work on client applications.

Developing a Website Directory for Young People: A Case Study Using Graduate Students in Library and Information Science

ERIC Educational Resources Information Center

Irwin, Enid; Haycock, Ken

2008-01-01

KidsClick! is a web-based instructional resource designed for K-12. In 2006 it was transferred to the San Jose State School of Library and Information Science, and was subsequently refocused for grades 4-9, ages 10-14, post-reading, and pre-adult reading level phases. This article describes three parts of the redesign project--content, interface,…

Geospatial analysis of spaceborne remote sensing data for assessing disaster impacts and modeling surface runoff in the built-environment

NASA Astrophysics Data System (ADS)

Wodajo, Bikila Teklu

Every year, coastal disasters such as hurricanes and floods claim hundreds of lives and severely damage homes, businesses, and lifeline infrastructure. This research was motivated by the 2005 Hurricane Katrina disaster, which devastated the Mississippi and Louisiana Gulf Coast. The primary objective was to develop a geospatial decision-support system for extracting built-up surfaces and estimating disaster impacts using spaceborne remote sensing satellite imagery. Pre-Katrina 1-m Ikonos imagery of a 5km x 10km area of Gulfport, Mississippi, was used as source data to develop the built-up area and natural surfaces or BANS classification methodology. Autocorrelation of 0.6 or higher values related to spectral reflectance values of groundtruth pixels were used to select spectral bands and establish the BANS decision criteria of unique ranges of reflectance values. Surface classification results using GeoMedia Pro geospatial analysis for Gulfport sample areas, based on BANS criteria and manually drawn polygons, were within +/-7% of the groundtruth. The difference between the BANS results and the groundtruth was statistically not significant. BANS is a significant improvement over other supervised classification methods, which showed only 50% correctly classified pixels. The storm debris and erosion estimation or SDE methodology was developed from analysis of pre- and post-Katrina surface classification results of Gulfport samples. The SDE severity level criteria considered hurricane and flood damages and vulnerability of inhabited built-environment. A linear regression model, with +0.93 Pearson R-value, was developed for predicting SDE as a function of pre-disaster percent built-up area. SDE predictions for Gulfport sample areas, used for validation, were within +/-4% of calculated values. The damage cost model considered maintenance, rehabilitation and reconstruction costs related to infrastructure damage and community impacts of Hurricane Katrina. The developed models were implemented for a study area along I-10 considering the predominantly flood-induced damages in New Orleans. The BANS methodology was calibrated for 0.6-m QuickBird2 multispectral imagery of Karachi Port area in Pakistan. The results were accurate within +/-6% of the groundtruth. Due to its computational simplicity, the unit hydrograph method is recommended for geospatial visualization of surface runoff in the built-environment using BANS surface classification maps and elevations data. Key words. geospatial analysis, satellite imagery, built-environment, hurricane, disaster impacts, runoff.

Application specific serial arithmetic arrays

NASA Technical Reports Server (NTRS)

Winters, K.; Mathews, D.; Thompson, T.

1990-01-01

High performance systolic arrays of serial-parallel multiplier elements may be rapidly constructed for specific applications by applying hardware description language techniques to a library of full-custom CMOS building blocks. Single clock pre-charged circuits have been implemented for these arrays at clock rates in excess of 100 Mhz using economical 2-micron (minimum feature size) CMOS processes, which may be quickly configured for a variety of applications. A number of application-specific arrays are presented, including a 2-D convolver for image processing, an integer polynomial solver, and a finite-field polynomial solver.

ChemTS: an efficient python library for de novo molecular generation.

PubMed

Yang, Xiufeng; Zhang, Jinzhe; Yoshizoe, Kazuki; Terayama, Kei; Tsuda, Koji

2017-01-01

Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network models such as variational autoencoders and recurrent neural networks (RNNs) are shown to be effective in de novo design of molecules without any predetermined fragments. This paper presents a novel Python library ChemTS that explores the chemical space by combining Monte Carlo tree search and an RNN. In a benchmarking problem of optimizing the octanol-water partition coefficient and synthesizability, our algorithm showed superior efficiency in finding high-scoring molecules. ChemTS is available at https://github.com/tsudalab/ChemTS.

ChemTS: an efficient python library for de novo molecular generation

NASA Astrophysics Data System (ADS)

Yang, Xiufeng; Zhang, Jinzhe; Yoshizoe, Kazuki; Terayama, Kei; Tsuda, Koji

2017-12-01

Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network models such as variational autoencoders and recurrent neural networks (RNNs) are shown to be effective in de novo design of molecules without any predetermined fragments. This paper presents a novel Python library ChemTS that explores the chemical space by combining Monte Carlo tree search and an RNN. In a benchmarking problem of optimizing the octanol-water partition coefficient and synthesizability, our algorithm showed superior efficiency in finding high-scoring molecules. ChemTS is available at https://github.com/tsudalab/ChemTS.

Use of integral experiments in support to the validation of JEFF-3.2 nuclear data evaluation

NASA Astrophysics Data System (ADS)

Leclaire, Nicolas; Cochet, Bertrand; Jinaphanh, Alexis; Haeck, Wim

2017-09-01

For many years now, IRSN has developed its own Monte Carlo continuous energy capability, which allows testing various nuclear data libraries. In that prospect, a validation database of 1136 experiments was built from cases used for the validation of the APOLLO2-MORET 5 multigroup route of the CRISTAL V2.0 package. In this paper, the keff obtained for more than 200 benchmarks using the JEFF-3.1.1 and JEFF-3.2 libraries are compared to benchmark keff values and main discrepancies are analyzed regarding the neutron spectrum. Special attention is paid on benchmarks for which the results have been highly modified between both JEFF-3 versions.

Customized Consensus Spectral Library Building for Untargeted Quantitative Metabolomics Analysis with Data Independent Acquisition Mass Spectrometry and MetaboDIA Workflow.

PubMed

Chen, Gengbo; Walmsley, Scott; Cheung, Gemmy C M; Chen, Liyan; Cheng, Ching-Yu; Beuerman, Roger W; Wong, Tien Yin; Zhou, Lei; Choi, Hyungwon

2017-05-02

Data independent acquisition-mass spectrometry (DIA-MS) coupled with liquid chromatography is a promising approach for rapid, automatic sampling of MS/MS data in untargeted metabolomics. However, wide isolation windows in DIA-MS generate MS/MS spectra containing a mixed population of fragment ions together with their precursor ions. This precursor-fragment ion map in a comprehensive MS/MS spectral library is crucial for relative quantification of fragment ions uniquely representative of each precursor ion. However, existing reference libraries are not sufficient for this purpose since the fragmentation patterns of small molecules can vary in different instrument setups. Here we developed a bioinformatics workflow called MetaboDIA to build customized MS/MS spectral libraries using a user's own data dependent acquisition (DDA) data and to perform MS/MS-based quantification with DIA data, thus complementing conventional MS1-based quantification. MetaboDIA also allows users to build a spectral library directly from DIA data in studies of a large sample size. Using a marine algae data set, we show that quantification of fragment ions extracted with a customized MS/MS library can provide as reliable quantitative data as the direct quantification of precursor ions based on MS1 data. To test its applicability in complex samples, we applied MetaboDIA to a clinical serum metabolomics data set, where we built a DDA-based spectral library containing consensus spectra for 1829 compounds. We performed fragment ion quantification using DIA data using this library, yielding sensitive differential expression analysis.

Dr. Mashup or, Why Educators Should Learn to Stop Worrying and Love the Remix

ERIC Educational Resources Information Center

Lamb, Brian

2007-01-01

A music track that lays a vocal from Madonna over guitars from the Sex Pistols. A classroom portal that presents automatically updated syndicated resources from the campus library, news sources, student events, weblogs, and podcasts and that was built quickly using free tools. A Web site that takes crime data from the Chicago Police and applies…

The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins

PubMed Central

Koide, Shohei; Sidhu, Sachdev S.

2010-01-01

Summary Combinatorial libraries built with severely restricted chemical diversity have yielded highly functional synthetic binding proteins. Structural analyses of these minimalist binding sites have revealed the dominant role of large tyrosine residues for mediating molecular contacts and of small serine/glycine residues for providing space and flexibility. The concept of using limited residue types to construct optimized binding proteins mirrors findings in the field of small molecule drug development, where it has been proposed that most drugs are built from a limited set of side chains presented by diverse frameworks. The physicochemical properties of tyrosine make it the amino acid that is most effective for mediating molecular recognition, and protein engineers have taken advantage of these characteristics to build tyrosine-rich protein binding sites that outperform natural proteins in terms of affinity and specificity. Knowledge from preceding studies can be used to improve current designs, and thus, synthetic protein libraries will continue to evolve and improve. In the near future, it seems likely that synthetic binding proteins will supersede natural antibodies for most purposes, and moreover, synthetic proteins will enable many new applications beyond the scope of natural proteins. PMID:19298050

The effects of signage and the physical environment on stair usage.

PubMed

Bungum, Tim; Meacham, Mindy; Truax, Nicole

2007-07-01

Physical activity (PA) is a health behavior that most Americans do not participate in at recommended levels. We sought to increase PA by use of motivational signs in selected buildings. Because physical environments are known to influence PA, the relationship of building characteristics and stair usage was also assessed. One pre- and two post-intervention observations were conducted. The proportion of those using the stairs increased from baseline to the second data collection, (chi2 = 39.31, p < 0.01) and baseline to a final data collection (chi2 = 10.1, p < 0.01). Built environment factors, including steps to the next higher floor and the number of floors in the building were consistent predictors of stair use. With signs positioned, the visibility of the stairs while standing in front of elevators became a significant predictor of stair usage. Motivational signs and characteristics of built environments are associated with increased stair usage.

ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis.

PubMed

Trümbach, Dietrich; Pfeiffer, Susanne; Poppe, Manuel; Scherb, Hagen; Doll, Sebastian; Wurst, Wolfgang; Schick, Joel A

2017-11-25

As CRISPR/Cas9 mediated screens with pooled guide libraries in somatic cells become increasingly established, an unmet need for rapid and accurate companion informatics tools has emerged. We have developed a lightweight and efficient software to easily manipulate large raw next generation sequencing datasets derived from such screens into informative relational context with graphical support. The advantages of the software entitled ENCoRE (Easy NGS-to-Gene CRISPR REsults) include a simple graphical workflow, platform independence, local and fast multithreaded processing, data pre-processing and gene mapping with custom library import. We demonstrate the capabilities of ENCoRE to interrogate results from a pooled CRISPR cellular viability screen following Tumor Necrosis Factor-alpha challenge. The results not only identified stereotypical players in extrinsic apoptotic signaling but two as yet uncharacterized members of the extrinsic apoptotic cascade, Smg7 and Ces2a. We further validated and characterized cell lines containing mutations in these genes against a panel of cell death stimuli and involvement in p53 signaling. In summary, this software enables bench scientists with sensitive data or without access to informatic cores to rapidly interpret results from large scale experiments resulting from pooled CRISPR/Cas9 library screens.

Librarian involvement in a nutrition undergraduate research course: preparing nutrition students for evidence-based practice.

PubMed

Smith, Susan C; Penumetcha, Meera

2010-01-01

Given the foundational importance of literature searching skills to later stages of research and, ultimately, evidence-based practice, the authors wanted to assess a unique strategy for teaching such skills. This pilot study describes the results of an undergraduate nutrition research course in which a librarian lead several class sessions. The goal of this study was to assess students' perceptions, attitudes and use of research literature and resources before and after a course partially taught by a librarian. Twenty-seven students enrolled in an undergraduate Introduction to Research course at Georgia State University were given pre- and post-test questionnaires at the beginning and end of a course that included three librarian-led class sessions. Most of the results indicate that the repeated involvement of a librarian enriched this particular undergraduate research course. By the end of the course, students were more comfortable in libraries and with using library resources; they used the campus library more frequently; they were more confident in their ability to find high-quality information on nutrition-related topics and identify strengths and weaknesses of different information sources; and they felt they gained skills that will help them achieve their educational and career goals.

A Framework for Evaluating Digital Library Services; Interdisciplinarity: The Road Ahead for Education in Digital Libraries; Federated Digital Rights Management: A Proposed DRM Solution for Research and Education; Learning Lessons Holistically in the Glasgow Digital Library.

ERIC Educational Resources Information Center

Choudhury, Sayeed; Hobbs, Benjamin; Lorie, Mark; Flores, Nicholas; Coleman, Anita; Martin, Mairead; Kuhlman, David L.; McNair, John H.; Rhodes, William A.; Tipton, Ron; Agnew, Grace; Nicholson, Dennis; Macgregor, George

2002-01-01

Includes four articles that address issues related to digital libraries. Highlights include a framework for evaluating digital library services, particularly academic research libraries; interdisciplinary approaches to education about digital libraries that includes library and information science and computing; digital rights management; and the…

Symposium on Presidential Libraries.

ERIC Educational Resources Information Center

Relyea, Harold C.; And Others

1994-01-01

Includes five articles that discuss presidential libraries. Highlights include an overview of the development of the federal presidential library system; the Ronald Reagan library; the Richard Nixon library archives; access at the Gerald Ford library; and computerizing the Jimmy Carter library. (LRW)

Gwyscan: a library to support non-equidistant scanning probe microscope measurements

NASA Astrophysics Data System (ADS)

Klapetek, Petr; Yacoot, Andrew; Grolich, Petr; Valtr, Miroslav; Nečas, David

2017-03-01

We present a software library and related methodology for enabling easy integration of adaptive step (non-equidistant) scanning techniques into metrological scanning probe microscopes or scanning probe microscopes where individual x, y position data are recorded during measurements. Scanning with adaptive steps can reduce the amount of data collected in SPM measurements thereby leading to faster data acquisition, a smaller amount of data collection required for a specific analytical task and less sensitivity to mechanical and thermal drift. Implementation of adaptive scanning routines into a custom built microscope is not normally an easy task: regular data are much easier to handle for previewing (e.g. levelling) and storage. We present an environment to make implementation of adaptive scanning easier for an instrument developer, specifically taking into account data acquisition approaches that are used in high accuracy microscopes as those developed by National Metrology Institutes. This includes a library with algorithms written in C and LabVIEW for handling data storage, regular mesh preview generation and planning the scan path on basis of different assumptions. A set of modules for Gwyddion open source software for handling these data and for their further analysis is presented. Using this combination of data acquisition and processing tools one can implement adaptive scanning in a relatively easy way into an instrument that was previously measuring on a regular grid. The performance of the presented approach is shown and general non-equidistant data processing steps are discussed.

Hyperspectral imaging of polymer banknotes for building and analysis of spectral library

NASA Astrophysics Data System (ADS)

Lim, Hoong-Ta; Murukeshan, Vadakke Matham

2017-11-01

The use of counterfeit banknotes increases crime rates and cripples the economy. New countermeasures are required to stop counterfeiters who use advancing technologies with criminal intent. Many countries started adopting polymer banknotes to replace paper notes, as polymer notes are more durable and have better quality. The research on authenticating such banknotes is of much interest to the forensic investigators. Hyperspectral imaging can be employed to build a spectral library of polymer notes, which can then be used for classification to authenticate these notes. This is however not widely reported and has become a research interest in forensic identification. This paper focuses on the use of hyperspectral imaging on polymer notes to build spectral libraries, using a pushbroom hyperspectral imager which has been previously reported. As an initial study, a spectral library will be built from three arbitrarily chosen regions of interest of five circulated genuine polymer notes. Principal component analysis is used for dimension reduction and to convert the information in the spectral library to principal components. A 99% confidence ellipse is formed around the cluster of principal component scores of each class and then used as classification criteria. The potential of the adopted methodology is demonstrated by the classification of the imaged regions as training samples.

Improving e-book access via a library-developed full-text search tool.

PubMed

Foust, Jill E; Bergen, Phillip; Maxeiner, Gretchen L; Pawlowski, Peter N

2007-01-01

This paper reports on the development of a tool for searching the contents of licensed full-text electronic book (e-book) collections. The Health Sciences Library System (HSLS) provides services to the University of Pittsburgh's medical programs and large academic health system. The HSLS has developed an innovative tool for federated searching of its e-book collections. Built using the XML-based Vivísimo development environment, the tool enables a user to perform a full-text search of over 2,500 titles from the library's seven most highly used e-book collections. From a single "Google-style" query, results are returned as an integrated set of links pointing directly to relevant sections of the full text. Results are also grouped into categories that enable more precise retrieval without reformulation of the search. A heuristic evaluation demonstrated the usability of the tool and a web server log analysis indicated an acceptable level of usage. Based on its success, there are plans to increase the number of online book collections searched. This library's first foray into federated searching has produced an effective tool for searching across large collections of full-text e-books and has provided a good foundation for the development of other library-based federated searching products.

Improving e-book access via a library-developed full-text search tool*

PubMed Central

Foust, Jill E.; Bergen, Phillip; Maxeiner, Gretchen L.; Pawlowski, Peter N.

2007-01-01

Purpose: This paper reports on the development of a tool for searching the contents of licensed full-text electronic book (e-book) collections. Setting: The Health Sciences Library System (HSLS) provides services to the University of Pittsburgh's medical programs and large academic health system. Brief Description: The HSLS has developed an innovative tool for federated searching of its e-book collections. Built using the XML-based Vivísimo development environment, the tool enables a user to perform a full-text search of over 2,500 titles from the library's seven most highly used e-book collections. From a single “Google-style” query, results are returned as an integrated set of links pointing directly to relevant sections of the full text. Results are also grouped into categories that enable more precise retrieval without reformulation of the search. Results/Evaluation: A heuristic evaluation demonstrated the usability of the tool and a web server log analysis indicated an acceptable level of usage. Based on its success, there are plans to increase the number of online book collections searched. Conclusion: This library's first foray into federated searching has produced an effective tool for searching across large collections of full-text e-books and has provided a good foundation for the development of other library-based federated searching products. PMID:17252065

SU-F-T-47: MRI T2 Exclusive Based Planning Using the Endocavitary/interstitial Gynecological Benidorm Applicator: A Proposed TPS Library and Preplan Efficient Methodology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richart, J; Otal, A; Rodriguez, S

Purpose: ABS and GEC-ESTRO have recommended MRI T2 for image guided brachytherapy. Recently, a new applicator (Benidorm Template, TB) has been developed in our Department (Rodriguez et al 2015). TB is fully MRI compatible because the Titanium needles and it allows the use of intrauterine tandem. Currently, TPS applicators library are not currently available for non-rigid applicators in case of interstitial component as the TB.The purpose of this work is to present the development of a library for the TB, together with its use on a pre-planning technique. Both new goals allow a very efficient and exclusive T2 MRI basedmore » planning clinical TB implementation. Methods: The developed library has been implemented in Oncentra Brachytherapy TPS, version 4.3.0 (Elekta) and now is being implemented on Sagiplan v 2.0 TPS (Eckert&Ziegler BEBIG). To model the TB, free and open software named FreeCAD and MeshLab have been used. The reconstruction process is based on three inserted A-vitamin pellets together with the data provided by the free length. The implemented preplanning procedure is as follow: 1) A MRI T2 acquisition is performed with the template in place just with the vaginal cylinder (no uterine tube nor needles). 2) The CTV is drawn and the required needles are selected using a developed Java based application and 3) A post-implant MRI T2 is performed. Results: This library procedure has been successfully applied by now in 25 patients. In this work the use of the developed library will be illustrated with clinical examples. The preplanning procedure has been applied by now in 6 patients, having significant advantages: needle depth estimation, needle positions and number are optimized a priori, time saving, etc Conclusion: TB library and pre-plan techniques are feasible and very efficient and their use will be illustrated in this work.« less

Comparison of several chemometric methods of libraries and classifiers for the analysis of expired drugs based on Raman spectra.

PubMed

Gao, Qun; Liu, Yan; Li, Hao; Chen, Hui; Chai, Yifeng; Lu, Feng

2014-06-01

Some expired drugs are difficult to detect by conventional means. If they are repackaged and sold back into market, they will constitute a new public health challenge. For the detection of repackaged expired drugs within specification, paracetamol tablet from a manufacturer was used as a model drug in this study for comparison of Raman spectra-based library verification and classification methods. Raman spectra of different batches of paracetamol tablets were collected and a library including standard spectra of unexpired batches of tablets was established. The Raman spectrum of each sample was identified by cosine and correlation with the standard spectrum. The average HQI of the suspicious samples and the standard spectrum were calculated. The optimum threshold values were 0.997 and 0.998 respectively as a result of ROC and four evaluations, for which the accuracy was up to 97%. Three supervised classifiers, PLS-DA, SVM and k-NN, were chosen to establish two-class classification models and compared subsequently. They were used to establish a classification of expired batches and an unexpired batch, and predict the suspect samples. The average accuracy was 90.12%, 96.80% and 89.37% respectively. Different pre-processing techniques were tried to find that first derivative was optimal for methods of libraries and max-min normalization was optimal for that of classifiers. The results obtained from these studies indicated both libraries and classifier methods could detect the expired drugs effectively, and they should be used complementarily in the fast-screening. Copyright © 2014 Elsevier B.V. All rights reserved.

Improving the quality of health care: using international collaboration to inform guideline programmes by founding the Guidelines International Network (G-I-N)*

PubMed Central

Ollenschlager, G; Marshall, C; Qureshi, S; Rosenbrand, K; Burgers, J; Makela, M; Slutsky, J; t for

2004-01-01



 Clinical practice guidelines are regarded as powerful tools to achieve effective health care. Although many countries have built up experience in the development, appraisal, and implementation of guidelines, until recently there has been no established forum for collaboration at an international level. As a result, in different countries seeking similar goals and using similar strategies, efforts have been unnecessarily duplicated and opportunities for harmonisation lost because of the lack of a supporting organisational framework. This triggered a proposal in 2001 for an international guidelines network built on existing partnerships. A baseline survey confirmed a strong demand for such an entity. A multinational group of guideline experts initiated the development of a non-profit organisation aimed at promotion of systematic guideline development and implementation. The Guidelines International Network (G-I-N) was founded in November 2002. One year later the Network released the International Guideline Library, a searchable database which now contains more than 2000 guideline resources including published guidelines, guidelines under development, "guidelines for guidelines", training materials, and patient information tools. By June 2004, 52 organisations from 27 countries had joined the network including institutions from Oceania, North America, and Europe, and WHO. This paper describes the process that led to the foundation of the G-I-N, its characteristics, prime activities, and ideas on future projects and collaboration. PMID:15576708

Computer-Aided Design for Built-In-Test (CADBIT) - Software Specification. Volume 3

DTIC Science & Technology

1989-10-01

CADD COMAN WIDO IO-CNURET MSL PPLYING~ TET ATEN Figur 3-13- TUTORIA FIGUR PLCMI IN CAD-NVIOMENT ON BOAR SEFTST- 1"os-rnenu, long-tur d nnnih que- list...have software package for reliability calculation A-8 LIBRARY ELEMENT DATA SHE T’" BIT TECHNIQUE: ON-BOARD ROM CATEGORY: L’ONG TUTORIA PAGE ,5 of 14

A Book Club for a Nation, Built Chapter by Chapter. The Big Read. Final Report

ERIC Educational Resources Information Center

Sloan, Kay; Honeyford, Michelle; Bass, Kristin

2008-01-01

This report shares the findings from a nineteen-month study of The Big Read, an initiative of the National Endowment for the Arts, in partnership with the Institute of Museum and Library Services and Arts Midwest, designed to restore reading to the center of American culture. Piloted in early 2006 and launched nationwide later that year, The Big…

KSC-06pd0396

NASA Image and Video Library

2006-03-01

KENNEDY SPACE CENTER, FLA. - The Operations Support Building II at NASA's Kennedy Space Center is seen here, newly built and landscaped. The building replaced modular housing and trailers in the Launch Complex 39 area. The five-story, 189,000-square-foot building consists of approximately 860 office spaces, training rooms, computer rooms, multimedia conference rooms, technical libraries, and a 352-person mission conference center with observation deck. Photo credit: Cory Huston

The Secure Medical Research Workspace: An IT Infrastructure to Enable Secure Research on Clinical Data

PubMed Central

Owen, Phillips; Mostafa, Javed; Lamm, Brent; Wang, Xiaoshu; Schmitt, Charles P.; Ahalt, Stanley C.

2013-01-01

Abstract Clinical data have tremendous value for translational research, but only if security and privacy concerns can be addressed satisfactorily. A collaboration of clinical and informatics teams, including RENCI, NC TraCS, UNC's School of Information and Library Science, Information Technology Service's Research Computing and other partners at the University of North Carolina at Chapel Hill have developed a system called the Secure Medical Research Workspace (SMRW) that enables researchers to use clinical data securely for research. SMRW significantly minimizes the risk presented when using identified clinical data, thereby protecting patients, researchers, and institutions associated with the data. The SMRW is built on a novel combination of virtualization and data leakage protection and can be combined with other protection methodologies and scaled to production levels. PMID:23751029

Pre-exposure rabies prophylaxis: a systematic review.

PubMed

Kessels, Jocelyn A; Recuenco, Sergio; Navarro-Vela, Ana Maria; Deray, Raffy; Vigilato, Marco; Ertl, Hildegund; Durrheim, David; Rees, Helen; Nel, Louis H; Abela-Ridder, Bernadette; Briggs, Deborah

2017-03-01

To review the safety and immunogenicity of pre-exposure rabies prophylaxis (including accelerated schedules, co-administration with other vaccines and booster doses), its cost-effectiveness and recommendations for use, particularly in high-risk settings. We searched the PubMed, Centre for Agriculture and Biosciences International, Cochrane Library and Web of Science databases for papers on pre-exposure rabies prophylaxis published between 2007 and 29 January 2016. We reviewed field data from pre-exposure prophylaxis campaigns in Peru and the Philippines. Pre-exposure rabies prophylaxis was safe and immunogenic in children and adults, also when co-administered with routine childhood vaccinations and the Japanese encephalitis vaccine. The evidence available indicates that shorter regimens and regimens involving fewer doses are safe and immunogenic and that booster intervals could be extended up to 10 years. The few studies on cost suggest that, at current vaccine and delivery costs, pre-exposure prophylaxis campaigns would not be cost-effective in most situations. Although pre-exposure prophylaxis has been advocated for high-risk populations, only Peru and the Philippines have implemented appropriate national programmes. In the future, accelerated regimens and novel vaccines could simplify delivery and increase affordability. Pre-exposure rabies prophylaxis is safe and immunogenic and should be considered: (i) where access to postexposure prophylaxis is limited or delayed; (ii) where the risk of exposure is high and may go unrecognized; and (iii) where controlling rabies in the animal reservoir is difficult. Pre-exposure prophylaxis should not distract from canine vaccination efforts, provision of postexposure prophylaxis or education to increase rabies awareness in local communities.

Pre-exposure rabies prophylaxis: a systematic review

PubMed Central

Recuenco, Sergio; Navarro-Vela, Ana Maria; Deray, Raffy; Vigilato, Marco; Ertl, Hildegund; Durrheim, David; Rees, Helen; Nel, Louis H; Abela-Ridder, Bernadette; Briggs, Deborah

2017-01-01

Abstract Objective To review the safety and immunogenicity of pre-exposure rabies prophylaxis (including accelerated schedules, co-administration with other vaccines and booster doses), its cost–effectiveness and recommendations for use, particularly in high-risk settings. Methods We searched the PubMed, Centre for Agriculture and Biosciences International, Cochrane Library and Web of Science databases for papers on pre-exposure rabies prophylaxis published between 2007 and 29 January 2016. We reviewed field data from pre-exposure prophylaxis campaigns in Peru and the Philippines. Findings Pre-exposure rabies prophylaxis was safe and immunogenic in children and adults, also when co-administered with routine childhood vaccinations and the Japanese encephalitis vaccine. The evidence available indicates that shorter regimens and regimens involving fewer doses are safe and immunogenic and that booster intervals could be extended up to 10 years. The few studies on cost suggest that, at current vaccine and delivery costs, pre-exposure prophylaxis campaigns would not be cost-effective in most situations. Although pre-exposure prophylaxis has been advocated for high-risk populations, only Peru and the Philippines have implemented appropriate national programmes. In the future, accelerated regimens and novel vaccines could simplify delivery and increase affordability. Conclusion Pre-exposure rabies prophylaxis is safe and immunogenic and should be considered: (i) where access to postexposure prophylaxis is limited or delayed; (ii) where the risk of exposure is high and may go unrecognized; and (iii) where controlling rabies in the animal reservoir is difficult. Pre-exposure prophylaxis should not distract from canine vaccination efforts, provision of postexposure prophylaxis or education to increase rabies awareness in local communities. PMID:28250534

CHEMICAL EVOLUTION LIBRARY FOR GALAXY FORMATION SIMULATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saitoh, Takayuki R., E-mail: saitoh@elsi.jp

We have developed a software library for chemical evolution simulations of galaxy formation under the simple stellar population (SSP) approximation. In this library, all of the necessary components concerning chemical evolution, such as initial mass functions, stellar lifetimes, yields from Type II and Type Ia supernovae, asymptotic giant branch stars, and neutron star mergers, are compiled from the literature. Various models are pre-implemented in this library so that users can choose their favorite combination of models. Subroutines of this library return released energy and masses of individual elements depending on a given event type. Since the redistribution manner of thesemore » quantities depends on the implementation of users’ simulation codes, this library leaves it up to the simulation code. As demonstrations, we carry out both one-zone, closed-box simulations and 3D simulations of a collapsing gas and dark matter system using this library. In these simulations, we can easily compare the impact of individual models on the chemical evolution of galaxies, just by changing the control flags and parameters of the library. Since this library only deals with the part of chemical evolution under the SSP approximation, any simulation codes that use the SSP approximation—namely, particle-base and mesh codes, as well as semianalytical models—can use it. This library is named “CELib” after the term “Chemical Evolution Library” and is made available to the community.« less

ChemTS: an efficient python library for de novo molecular generation

PubMed Central

Yang, Xiufeng; Zhang, Jinzhe; Yoshizoe, Kazuki; Terayama, Kei; Tsuda, Koji

2017-01-01

Abstract Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network models such as variational autoencoders and recurrent neural networks (RNNs) are shown to be effective in de novo design of molecules without any predetermined fragments. This paper presents a novel Python library ChemTS that explores the chemical space by combining Monte Carlo tree search and an RNN. In a benchmarking problem of optimizing the octanol-water partition coefficient and synthesizability, our algorithm showed superior efficiency in finding high-scoring molecules. ChemTS is available at https://github.com/tsudalab/ChemTS. PMID:29435094

Global magnetosphere simulations using constrained-transport Hall-MHD with CWENO reconstruction

NASA Astrophysics Data System (ADS)

Lin, L.; Germaschewski, K.; Maynard, K. M.; Abbott, S.; Bhattacharjee, A.; Raeder, J.

2013-12-01

We present a new CWENO (Centrally-Weighted Essentially Non-Oscillatory) reconstruction based MHD solver for the OpenGGCM global magnetosphere code. The solver was built using libMRC, a library for creating efficient parallel PDE solvers on structured grids. The use of libMRC gives us access to its core functionality of providing an automated code generation framework which takes a user provided PDE right hand side in symbolic form to generate an efficient, computer architecture specific, parallel code. libMRC also supports block-structured adaptive mesh refinement and implicit-time stepping through integration with the PETSc library. We validate the new CWENO Hall-MHD solver against existing solvers both in standard test problems as well as in global magnetosphere simulations.

Summer Workshop in Metagenomics: One Week Plus Eight Students Equals Gigabases of Cloned DNA †

PubMed Central

Rios-Velazquez, Carlos; Williamson, Lynn L.; Cloud-Hansen, Karen A.; Allen, Heather K.; McMahon, Mathew D.; Sabree, Zakee L.; Donato, Justin J.; Handelsman, Jo

2011-01-01

We designed a week-long laboratory workshop in metagenomics for a cohort of undergraduate student researchers. During this course, students learned and utilized molecular biology and microbiology techniques to construct a metagenomic library from Puerto Rican soil. Pre-and postworkshop assessments indicated student learning gains in technical knowledge, skills, and confidence in a research environment. Postworkshop construction of additional libraries demonstrated retention of research techniques by the students. PMID:23653755

Third World Libraries; Is There an American Role?

ERIC Educational Resources Information Center

Sager, Donald J.

1994-01-01

Presents viewpoints of four library professionals on the role of American libraries in the development of third world libraries. Topics discussed include the role of libraries in democracies; financial and human resource needs; the role of library associations; and staff exchange programs, including the American Library Association's Library…

United States Department of Agriculture-Agricultural Research Service research on alternatives to methyl bromide: pre-plant and post-harvest.

PubMed

Schneider, Sally M; Rosskopf, Erin N; Leesch, James G; Chellemi, Daniel O; Bull, Carolee T; Mazzola, Mark

2003-01-01

Methyl bromide is a widely used fumigant for both pre-plant and post-harvest pest and pathogen control. The Montreal Protocol and the US Clean Air Act mandate a phase-out of the import and manufacture of methyl bromide, beginning in 2001 and culminating with a complete ban, except for quarantine and certain pre-shipment uses and exempted critical uses, in January 2005. In 1995, ARS built on its existing programs in soil-borne plant pathology and post-harvest entomology and plant pathology to initiate a national research program to develop alternatives to methyl bromide. The focus has been on strawberry, pepper, tomato, perennial and nursery cropping systems for pre-plant methyl bromide use and fresh and durable commodities for post-harvest use. Recently the program has been expanded to include research on alternatives for the ornamental and cut flower cropping systems. An overview of the national research program is presented. Results from four specific research trials are presented, ranging from organic to conventional systems. Good progress on short-term alternatives is being made. These will be used as the foundation of integrated management systems which begin with pre-plant management decisions and continue through post-harvest processing.

The Ways We Serve.

ERIC Educational Resources Information Center

Leonard, Gloria; And Others

1991-01-01

Four articles discuss library services to diverse user groups. Highlights include the Seattle Public Library's Human Diversity Training Program for library staff; cultural diversity at the University of Northern Colorado, including library collection development; information needs of physicists in special libraries; and library services to…

Perl-speaks-NONMEM (PsN)--a Perl module for NONMEM related programming.

PubMed

Lindbom, Lars; Ribbing, Jakob; Jonsson, E Niclas

2004-08-01

The NONMEM program is the most widely used nonlinear regression software in population pharmacokinetic/pharmacodynamic (PK/PD) analyses. In this article we describe a programming library, Perl-speaks-NONMEM (PsN), intended for programmers that aim at using the computational capability of NONMEM in external applications. The library is object oriented and written in the programming language Perl. The classes of the library are built around NONMEM's data, model and output files. The specification of the NONMEM model is easily set or changed through the model and data file classes while the output from a model fit is accessed through the output file class. The classes have methods that help the programmer perform common repetitive tasks, e.g. summarising the output from a NONMEM run, setting the initial estimates of a model based on a previous run or truncating values over a certain threshold in the data file. PsN creates a basis for the development of high-level software using NONMEM as the regression tool.

Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes.

PubMed

Lee, Nam-Kyung; Bidlingmaier, Scott; Su, Yang; Liu, Bin

2018-01-01

Monoclonal antibodies and antibody-derived therapeutics have emerged as a rapidly growing class of biological drugs for the treatment of cancer, autoimmunity, infection, and neurological diseases. To support the development of human antibodies, various display techniques based on antibody gene repertoires have been constructed over the last two decades. In particular, scFv-antibody phage display has been extensively utilized to select lead antibodies against a variety of target antigens. To construct a scFv phage display that enables efficient antibody discovery, and optimization, it is desirable to develop a system that allows modular assembly of highly diverse variable heavy chain and light chain (Vκ and Vλ) repertoires. Here, we describe modular construction of large non-immune human antibody phage-display libraries built on variable gene cassettes from heavy chain and light chain repertoires (Vκ- and Vλ-light can be made into independent cassettes). We describe utility of such libraries in antibody discovery and optimization through chain shuffling.

Knowledge Preservation and Web-tools

NASA Technical Reports Server (NTRS)

Moreman, Douglas; Dyer, John; Ahmad, Rashed

1998-01-01

We propose a library of "netbooks" as part of a national effort, preserving the wisdom of the early Space Program. NASA is losing its rocket scientists who designed the great systems of the past. Few new systems of similar ambition are being built; much of the expertise that took us to the Moon is evaporating. With retiring NASA designers, we work to preserve something of the expertise of these individuals, developed at great national cost. We show others the tools that make preservation easy and cheap. Retiring engineers and scientists can be coached into speaking (without charge) into recording devices about ideas not widely appreciated but of potential future value. Transcripts of the recordings and the audio itself are combined (cheaply) in netbooks accessible via a standard web-browser (free). Selected netbooks are indexed into a rapidly searchable system, an electronic Library. We recruit support in establishing a standards committee for that Library. The system is to be a model for access by the blind as well as for preservation of important, technical knowledge.

How to use MPI communication in highly parallel climate simulations more easily and more efficiently.

NASA Astrophysics Data System (ADS)

Behrens, Jörg; Hanke, Moritz; Jahns, Thomas

2014-05-01

In this talk we present a way to facilitate efficient use of MPI communication for developers of climate models. Exploitation of the performance potential of today's highly parallel supercomputers with real world simulations is a complex task. This is partly caused by the low level nature of the MPI communication library which is the dominant communication tool at least for inter-node communication. In order to manage the complexity of the task, climate simulations with non-trivial communication patterns often use an internal abstraction layer above MPI without exploiting the benefits of communication aggregation or MPI-datatypes. The solution for the complexity and performance problem we propose is the communication library YAXT. This library is built on top of MPI and takes high level descriptions of arbitrary domain decompositions and automatically derives an efficient collective data exchange. Several exchanges can be aggregated in order to reduce latency costs. Examples are given which demonstrate the simplicity and the performance gains for selected climate applications.

Communication library for run-time visualization of distributed, asynchronous data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rowlan, J.; Wightman, B.T.

1994-04-01

In this paper we present a method for collecting and visualizing data generated by a parallel computational simulation during run time. Data distributed across multiple processes is sent across parallel communication lines to a remote workstation, which sorts and queues the data for visualization. We have implemented our method in a set of tools called PORTAL (for Parallel aRchitecture data-TrAnsfer Library). The tools comprise generic routines for sending data from a parallel program (callable from either C or FORTRAN), a semi-parallel communication scheme currently built upon Unix Sockets, and a real-time connection to the scientific visualization program AVS. Our methodmore » is most valuable when used to examine large datasets that can be efficiently generated and do not need to be stored on disk. The PORTAL source libraries, detailed documentation, and a working example can be obtained by anonymous ftp from info.mcs.anl.gov from the file portal.tar.Z from the directory pub/portal.« less

An Interaction Library for the FcεRI Signaling Network

DOE PAGES

Chylek, Lily A.; Holowka, David A.; Baird, Barbara A.; ...

2014-04-15

Antigen receptors play a central role in adaptive immune responses. Although the molecular networks associated with these receptors have been extensively studied, we currently lack a systems-level understanding of how combinations of non-covalent interactions and post-translational modifications are regulated during signaling to impact cellular decision-making. To fill this knowledge gap, it will be necessary to formalize and piece together information about individual molecular mechanisms to form large-scale computational models of signaling networks. To this end, we have developed an interaction library for signaling by the high-affinity IgE receptor, FcεRI. The library consists of executable rules for protein–protein and protein–lipid interactions.more » This library extends earlier models for FcεRI signaling and introduces new interactions that have not previously been considered in a model. Thus, this interaction library is a toolkit with which existing models can be expanded and from which new models can be built. As an example, we present models of branching pathways from the adaptor protein Lat, which influence production of the phospholipid PIP 3 at the plasma membrane and the soluble second messenger IP 3. We find that inclusion of a positive feedback loop gives rise to a bistable switch, which may ensure robust responses to stimulation above a threshold level. In addition, the library is visualized to facilitate understanding of network circuitry and identification of network motifs.« less

Systematic design methodology for robust genetic transistors based on I/O specifications via promoter-RBS libraries.

PubMed

Lee, Yi-Ying; Hsu, Chih-Yuan; Lin, Ling-Jiun; Chang, Chih-Chun; Cheng, Hsiao-Chun; Yeh, Tsung-Hsien; Hu, Rei-Hsing; Lin, Che; Xie, Zhen; Chen, Bor-Sen

2013-10-27

Synthetic genetic transistors are vital for signal amplification and switching in genetic circuits. However, it is still problematic to efficiently select the adequate promoters, Ribosome Binding Sides (RBSs) and inducer concentrations to construct a genetic transistor with the desired linear amplification or switching in the Input/Output (I/O) characteristics for practical applications. Three kinds of promoter-RBS libraries, i.e., a constitutive promoter-RBS library, a repressor-regulated promoter-RBS library and an activator-regulated promoter-RBS library, are constructed for systematic genetic circuit design using the identified kinetic strengths of their promoter-RBS components.According to the dynamic model of genetic transistors, a design methodology for genetic transistors via a Genetic Algorithm (GA)-based searching algorithm is developed to search for a set of promoter-RBS components and adequate concentrations of inducers to achieve the prescribed I/O characteristics of a genetic transistor. Furthermore, according to design specifications for different types of genetic transistors, a look-up table is built for genetic transistor design, from which we could easily select an adequate set of promoter-RBS components and adequate concentrations of external inducers for a specific genetic transistor. This systematic design method will reduce the time spent using trial-and-error methods in the experimental procedure for a genetic transistor with a desired I/O characteristic. We demonstrate the applicability of our design methodology to genetic transistors that have desirable linear amplification or switching by employing promoter-RBS library searching.

Systematic design methodology for robust genetic transistors based on I/O specifications via promoter-RBS libraries

PubMed Central

2013-01-01

Background Synthetic genetic transistors are vital for signal amplification and switching in genetic circuits. However, it is still problematic to efficiently select the adequate promoters, Ribosome Binding Sides (RBSs) and inducer concentrations to construct a genetic transistor with the desired linear amplification or switching in the Input/Output (I/O) characteristics for practical applications. Results Three kinds of promoter-RBS libraries, i.e., a constitutive promoter-RBS library, a repressor-regulated promoter-RBS library and an activator-regulated promoter-RBS library, are constructed for systematic genetic circuit design using the identified kinetic strengths of their promoter-RBS components. According to the dynamic model of genetic transistors, a design methodology for genetic transistors via a Genetic Algorithm (GA)-based searching algorithm is developed to search for a set of promoter-RBS components and adequate concentrations of inducers to achieve the prescribed I/O characteristics of a genetic transistor. Furthermore, according to design specifications for different types of genetic transistors, a look-up table is built for genetic transistor design, from which we could easily select an adequate set of promoter-RBS components and adequate concentrations of external inducers for a specific genetic transistor. Conclusion This systematic design method will reduce the time spent using trial-and-error methods in the experimental procedure for a genetic transistor with a desired I/O characteristic. We demonstrate the applicability of our design methodology to genetic transistors that have desirable linear amplification or switching by employing promoter-RBS library searching. PMID:24160305

An Interaction Library for the FcεRI Signaling Network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chylek, Lily A.; Holowka, David A.; Baird, Barbara A.

Antigen receptors play a central role in adaptive immune responses. Although the molecular networks associated with these receptors have been extensively studied, we currently lack a systems-level understanding of how combinations of non-covalent interactions and post-translational modifications are regulated during signaling to impact cellular decision-making. To fill this knowledge gap, it will be necessary to formalize and piece together information about individual molecular mechanisms to form large-scale computational models of signaling networks. To this end, we have developed an interaction library for signaling by the high-affinity IgE receptor, FcεRI. The library consists of executable rules for protein–protein and protein–lipid interactions.more » This library extends earlier models for FcεRI signaling and introduces new interactions that have not previously been considered in a model. Thus, this interaction library is a toolkit with which existing models can be expanded and from which new models can be built. As an example, we present models of branching pathways from the adaptor protein Lat, which influence production of the phospholipid PIP 3 at the plasma membrane and the soluble second messenger IP 3. We find that inclusion of a positive feedback loop gives rise to a bistable switch, which may ensure robust responses to stimulation above a threshold level. In addition, the library is visualized to facilitate understanding of network circuitry and identification of network motifs.« less

The Gaia FGK benchmark stars. High resolution spectral library

NASA Astrophysics Data System (ADS)

Blanco-Cuaresma, S.; Soubiran, C.; Jofré, P.; Heiter, U.

2014-06-01

Context. An increasing number of high-resolution stellar spectra is available today thanks to many past and ongoing spectroscopic surveys. Consequently, numerous methods have been developed to perform an automatic spectral analysis on a massive amount of data. When reviewing published results, biases arise and they need to be addressed and minimized. Aims: We are providing a homogeneous library with a common set of calibration stars (known as the Gaia FGK benchmark stars) that will allow us to assess stellar analysis methods and calibrate spectroscopic surveys. Methods: High-resolution and signal-to-noise spectra were compiled from different instruments. We developed an automatic process to homogenize the observed data and assess the quality of the resulting library. Results: We built a high-quality library that will facilitate the assessment of spectral analyses and the calibration of present and future spectroscopic surveys. The automation of the process minimizes the human subjectivity and ensures reproducibility. Additionally, it allows us to quickly adapt the library to specific needs that can arise from future spectroscopic analyses. Based on NARVAL and HARPS data obtained within the Gaia Data Processing and Analysis Consortium (DPAC) and coordinated by the GBOG (Ground-Based Observations for Gaia) working group, and on data retrieved from the ESO-ADP database.The library of spectra is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/566/A98

Characteristics of personal health records: findings of the Medical Library Association/National Library of Medicine Joint Electronic Personal Health Record Task Force.

PubMed

Jones, Dixie A; Shipman, Jean P; Plaut, Daphne A; Selden, Catherine R

2010-07-01

The Medical Library Association (MLA)/National Library of Medicine (NLM) Joint Electronic Personal Health Record Task Force examined the current state of personal health records (PHRs). A working definition of PHRs was formulated, and a database was built with fields for specified PHR characteristics. PHRs were identified and listed. Each task force member was assigned a portion of the list for data gathering. Findings were recorded in the database. Of the 117 PHRs identified, 91 were viable. Almost half were standalone products. A number used national standards for nomenclature and/or record structure. Less than half were mobile device enabled. Some were publicly available, and others were offered only to enrollees of particular health plans or employees at particular institutions. A few were targeted to special health conditions. The PHR field is very dynamic. While most PHR products have some common elements, their features can vary. PHRs can link their users with librarians and information resources. MLA and NLM have taken an active role in making this connection and in encouraging librarians to assume this assistance role with PHRs.

Implementation of Open-Source Web Mapping Technologies to Support Monitoring of Governmental Schemes

NASA Astrophysics Data System (ADS)

Pulsani, B. R.

2015-10-01

Several schemes are undertaken by the government to uplift social and economic condition of people. The monitoring of these schemes is done through information technology where involvement of Geographic Information System (GIS) is lacking. To demonstrate the benefits of thematic mapping as a tool for assisting the officials in making decisions, a web mapping application for three government programs such as Mother and Child Tracking system (MCTS), Telangana State Housing Corporation Limited (TSHCL) and Ground Water Quality Mapping (GWQM) has been built. Indeed the three applications depicted the distribution of various parameters thematically and helped in identifying the areas with higher and weaker distributions. Based on the three applications, the study tends to find similarities of many government schemes reflecting the nature of thematic mapping and hence deduces to implement this kind of approach for other schemes as well. These applications have been developed using SharpMap Csharp library which is a free and open source mapping library for developing geospatial applications. The study highlights upon the cost benefits of SharpMap and brings out the advantage of this library over proprietary vendors and further discusses its advantages over other open source libraries as well.

Automated reuseable components system study results

NASA Technical Reports Server (NTRS)

Gilroy, Kathy

1989-01-01

The Automated Reusable Components System (ARCS) was developed under a Phase 1 Small Business Innovative Research (SBIR) contract for the U.S. Army CECOM. The objectives of the ARCS program were: (1) to investigate issues associated with automated reuse of software components, identify alternative approaches, and select promising technologies, and (2) to develop tools that support component classification and retrieval. The approach followed was to research emerging techniques and experimental applications associated with reusable software libraries, to investigate the more mature information retrieval technologies for applicability, and to investigate the applicability of specialized technologies to improve the effectiveness of a reusable component library. Various classification schemes and retrieval techniques were identified and evaluated for potential application in an automated library system for reusable components. Strategies for library organization and management, component submittal and storage, and component search and retrieval were developed. A prototype ARCS was built to demonstrate the feasibility of automating the reuse process. The prototype was created using a subset of the classification and retrieval techniques that were investigated. The demonstration system was exercised and evaluated using reusable Ada components selected from the public domain. A requirements specification for a production-quality ARCS was also developed.

Library Research and Statistics. Research on Libraries and Librarianship in 2002; Number of Libraries in the United States and Canada; Highlights of NCES Surveys; Library Acquisition Expenditures, 2001-2002: U.S. Public, Academic, Special, and Government Libraries; LJ Budget Report: A Precarious Holding Pattern; Price Indexes for Public and Academic Libraries; Library Buildings 2002: The Building Buck Doesn't Stop Here.

ERIC Educational Resources Information Center

Lynch, Mary Jo; Oder, Norman; Halstead, Kent; Fox, Bette-Lee

2003-01-01

Includes seven reports that discuss research on libraries and librarianship, including academic, public, and school libraries; awards and grants; number of libraries in the United States and Canada; National Center for Education Statistics results; library expenditures for public, academic, special, and government libraries; library budgets; price…

Efficient engineering of chromosomal ribosome binding site libraries in mismatch repair proficient Escherichia coli.

PubMed

Oesterle, Sabine; Gerngross, Daniel; Schmitt, Steven; Roberts, Tania Michelle; Panke, Sven

2017-09-26

Multiplexed gene expression optimization via modulation of gene translation efficiency through ribosome binding site (RBS) engineering is a valuable approach for optimizing artificial properties in bacteria, ranging from genetic circuits to production pathways. Established algorithms design smart RBS-libraries based on a single partially-degenerate sequence that efficiently samples the entire space of translation initiation rates. However, the sequence space that is accessible when integrating the library by CRISPR/Cas9-based genome editing is severely restricted by DNA mismatch repair (MMR) systems. MMR efficiency depends on the type and length of the mismatch and thus effectively removes potential library members from the pool. Rather than working in MMR-deficient strains, which accumulate off-target mutations, or depending on temporary MMR inactivation, which requires additional steps, we eliminate this limitation by developing a pre-selection rule of genome-library-optimized-sequences (GLOS) that enables introducing large functional diversity into MMR-proficient strains with sequences that are no longer subject to MMR-processing. We implement several GLOS-libraries in Escherichia coli and show that GLOS-libraries indeed retain diversity during genome editing and that such libraries can be used in complex genome editing operations such as concomitant deletions. We argue that this approach allows for stable and efficient fine tuning of chromosomal functions with minimal effort.

Advances in Software Tools for Pre-processing and Post-processing of Overset Grid Computations

NASA Technical Reports Server (NTRS)

Chan, William M.

2004-01-01

Recent developments in three pieces of software for performing pre-processing and post-processing work on numerical computations using overset grids are presented. The first is the OVERGRID graphical interface which provides a unified environment for the visualization, manipulation, generation and diagnostics of geometry and grids. Modules are also available for automatic boundary conditions detection, flow solver input preparation, multiple component dynamics input preparation and dynamics animation, simple solution viewing for moving components, and debris trajectory analysis input preparation. The second is a grid generation script library that enables rapid creation of grid generation scripts. A sample of recent applications will be described. The third is the OVERPLOT graphical interface for displaying and analyzing history files generated by the flow solver. Data displayed include residuals, component forces and moments, number of supersonic and reverse flow points, and various dynamics parameters.

Educational activities of remote sensing archaeology (Conference Presentation)

NASA Astrophysics Data System (ADS)

Hadjimitsis, Diofantos G.; Agapiou, Athos; Lysandrou, Vasilki; Themistocleous, Kyriacos; Cuca, Branka; Nisantzi, Argyro; Lasaponara, Rosa; Masini, Nicola; Krauss, Thomas; Cerra, Daniele; Gessner, Ursula; Schreier, Gunter

2016-10-01

Remote sensing science is increasingly being used to support archaeological and cultural heritage research in various ways. Satellite sensors either passive or active are currently used in a systematic basis to detect buried archaeological remains and to systematic monitor tangible heritage. In addition, airborne and low altitude systems are being used for documentation purposes. Ground surveys using remote sensing tools such as spectroradiometers and ground penetrating radars can detect variations of vegetation and soil respectively, which are linked to the presence of underground archaeological features. Education activities and training of remote sensing archaeology to young people is characterized of highly importance. Specific remote sensing tools relevant for archaeological research can be developed including web tools, small libraries, interactive learning games etc. These tools can be then combined and aligned with archaeology and cultural heritage. This can be achieved by presenting historical and pre-historical records, excavated sites or even artifacts under a "remote sensing" approach. Using such non-form educational approach, the students can be involved, ask, read, and seek to learn more about remote sensing and of course to learn about history. The paper aims to present a modern didactical concept and some examples of practical implementation of remote sensing archaeology in secondary schools in Cyprus. The idea was built upon an ongoing project (ATHENA) focused on the sue of remote sensing for archaeological research in Cyprus. Through H2020 ATHENA project, the Remote Sensing Science and Geo-Environment Research Laboratory at the Cyprus University of Technology (CUT), with the support of the National Research Council of Italy (CNR) and the German Aerospace Centre (DLR) aims to enhance its performance in all these new technologies.

PROFIT: Bayesian profile fitting of galaxy images

NASA Astrophysics Data System (ADS)

Robotham, A. S. G.; Taranu, D. S.; Tobar, R.; Moffett, A.; Driver, S. P.

2017-04-01

We present PROFIT, a new code for Bayesian two-dimensional photometric galaxy profile modelling. PROFIT consists of a low-level C++ library (libprofit), accessible via a command-line interface and documented API, along with high-level R (PROFIT) and PYTHON (PyProFit) interfaces (available at github.com/ICRAR/libprofit, github.com/ICRAR/ProFit, and github.com/ICRAR/pyprofit, respectively). R PROFIT is also available pre-built from CRAN; however, this version will be slightly behind the latest GitHub version. libprofit offers fast and accurate two-dimensional integration for a useful number of profiles, including Sérsic, Core-Sérsic, broken-exponential, Ferrer, Moffat, empirical King, point-source, and sky, with a simple mechanism for adding new profiles. We show detailed comparisons between libprofit and GALFIT. libprofit is both faster and more accurate than GALFIT at integrating the ubiquitous Sérsic profile for the most common values of the Sérsic index n (0.5 < n < 8). The high-level fitting code PROFIT is tested on a sample of galaxies with both SDSS and deeper KiDS imaging. We find good agreement in the fit parameters, with larger scatter in best-fitting parameters from fitting images from different sources (SDSS versus KiDS) than from using different codes (PROFIT versus GALFIT). A large suite of Monte Carlo-simulated images are used to assess prospects for automated bulge-disc decomposition with PROFIT on SDSS, KiDS, and future LSST imaging. We find that the biggest increases in fit quality come from moving from SDSS- to KiDS-quality data, with less significant gains moving from KiDS to LSST.

Remote sensing based on hyperspectral data analysis

NASA Astrophysics Data System (ADS)

Sharifahmadian, Ershad

In remote sensing, accurate identification of far objects, especially concealed objects is difficult. In this study, to improve object detection from a distance, the hyperspecral imaging and wideband technology are employed with the emphasis on wideband radar. As the wideband data includes a broad range of frequencies, it can reveal information about both the surface of the object and its content. Two main contributions are made in this study: 1) Developing concept of return loss for target detection: Unlike typical radar detection methods which uses radar cross section to detect an object, it is possible to enhance the process of detection and identification of concealed targets using the wideband radar based on the electromagnetic characteristics --conductivity, permeability, permittivity, and return loss-- of materials. During the identification process, collected wideband data is evaluated with information from wideband signature library which has already been built. In fact, several classes (e.g. metal, wood, etc.) and subclasses (ex. metals with high conductivity) have been defined based on their electromagnetic characteristics. Materials in a scene are then classified based on these classes. As an example, materials with high electrical conductivity can be conveniently detected. In fact, increasing relative conductivity leads to a reduction in the return loss. Therefore, metals with high conductivity (ex. copper) shows stronger radar reflections compared with metals with low conductivity (ex. stainless steel). Thus, it is possible to appropriately discriminate copper from stainless steel. 2) Target recognition techniques: To detect and identify targets, several techniques have been proposed, in particular the Multi-Spectral Wideband Radar Image (MSWRI) which is able to localize and identify concealed targets. The MSWRI is based on the theory of robust capon beamformer. During identification process, information from wideband signature library is utilized. The WB signature library includes such parameters as conductivity, permeability, permittivity, and return loss at different frequencies for possible materials related to a target. In the MSWRI approach, identification procedure is performed by calculating the RLs at different selected frequencies. Based on similarity of the calculated RLs and RL from WB signature library, targets are detected and identified. Based on the simulation and experimental results, it is concluded that the MSWRI technique is a promising approach for standoff target detection.

Modelica buildings library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wetter, Michael; Zuo, Wangda; Nouidui, Thierry S.

This paper describes the Buildings library, a free open-source library that is implemented in Modelica, an equation-based object-oriented modeling language. The library supports rapid prototyping, as well as design and operation of building energy and control systems. First, we describe the scope of the library, which covers HVAC systems, multi-zone heat transfer and multi-zone airflow and contaminant transport. Next, we describe differentiability requirements and address how we implemented them. We describe the class hierarchy that allows implementing component models by extending partial implementations of base models of heat and mass exchangers, and by instantiating basic models for conservation equations andmore » flow resistances. We also describe associated tools for pre- and post-processing, regression tests, co-simulation and real-time data exchange with building automation systems. Furthermore, the paper closes with an example of a chilled water plant, with and without water-side economizer, in which we analyzed the system-level efficiency for different control setpoints.« less

PrecisePrimer: an easy-to-use web server for designing PCR primers for DNA library cloning and DNA shuffling.

PubMed

Pauthenier, Cyrille; Faulon, Jean-Loup

2014-07-01

PrecisePrimer is a web-based primer design software made to assist experimentalists in any repetitive primer design task such as preparing, cloning and shuffling DNA libraries. Unlike other popular primer design tools, it is conceived to generate primer libraries with popular PCR polymerase buffers proposed as pre-set options. PrecisePrimer is also meant to design primers in batches, such as for DNA libraries creation of DNA shuffling experiments and to have the simplest interface possible. It integrates the most up-to-date melting temperature algorithms validated with experimental data, and cross validated with other computational tools. We generated a library of primers for the extraction and cloning of 61 genes from yeast DNA genomic extract using default parameters. All primer pairs efficiently amplified their target without any optimization of the PCR conditions. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Modelica buildings library

DOE PAGES

Wetter, Michael; Zuo, Wangda; Nouidui, Thierry S.; ...

2013-03-13

This paper describes the Buildings library, a free open-source library that is implemented in Modelica, an equation-based object-oriented modeling language. The library supports rapid prototyping, as well as design and operation of building energy and control systems. First, we describe the scope of the library, which covers HVAC systems, multi-zone heat transfer and multi-zone airflow and contaminant transport. Next, we describe differentiability requirements and address how we implemented them. We describe the class hierarchy that allows implementing component models by extending partial implementations of base models of heat and mass exchangers, and by instantiating basic models for conservation equations andmore » flow resistances. We also describe associated tools for pre- and post-processing, regression tests, co-simulation and real-time data exchange with building automation systems. Furthermore, the paper closes with an example of a chilled water plant, with and without water-side economizer, in which we analyzed the system-level efficiency for different control setpoints.« less

Architecture Adaptive Computing Environment

NASA Technical Reports Server (NTRS)

Dorband, John E.

2006-01-01

Architecture Adaptive Computing Environment (aCe) is a software system that includes a language, compiler, and run-time library for parallel computing. aCe was developed to enable programmers to write programs, more easily than was previously possible, for a variety of parallel computing architectures. Heretofore, it has been perceived to be difficult to write parallel programs for parallel computers and more difficult to port the programs to different parallel computing architectures. In contrast, aCe is supportable on all high-performance computing architectures. Currently, it is supported on LINUX clusters. aCe uses parallel programming constructs that facilitate writing of parallel programs. Such constructs were used in single-instruction/multiple-data (SIMD) programming languages of the 1980s, including Parallel Pascal, Parallel Forth, C*, *LISP, and MasPar MPL. In aCe, these constructs are extended and implemented for both SIMD and multiple- instruction/multiple-data (MIMD) architectures. Two new constructs incorporated in aCe are those of (1) scalar and virtual variables and (2) pre-computed paths. The scalar-and-virtual-variables construct increases flexibility in optimizing memory utilization in various architectures. The pre-computed-paths construct enables the compiler to pre-compute part of a communication operation once, rather than computing it every time the communication operation is performed.

VIP: Vortex Image Processing Package for High-contrast Direct Imaging

NASA Astrophysics Data System (ADS)

Gomez Gonzalez, Carlos Alberto; Wertz, Olivier; Absil, Olivier; Christiaens, Valentin; Defrère, Denis; Mawet, Dimitri; Milli, Julien; Absil, Pierre-Antoine; Van Droogenbroeck, Marc; Cantalloube, Faustine; Hinz, Philip M.; Skemer, Andrew J.; Karlsson, Mikael; Surdej, Jean

2017-07-01

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to provide a flexible framework for high-contrast data and image processing. In this paper, we describe the capabilities of VIP related to processing image sequences acquired using the angular differential imaging (ADI) observing technique. VIP implements functionalities for building high-contrast data processing pipelines, encompassing pre- and post-processing algorithms, potential source position and flux estimation, and sensitivity curve generation. Among the reference point-spread function subtraction techniques for ADI post-processing, VIP includes several flavors of principal component analysis (PCA) based algorithms, such as annular PCA and incremental PCA algorithms capable of processing big datacubes (of several gigabytes) on a computer with limited memory. Also, we present a novel ADI algorithm based on non-negative matrix factorization, which comes from the same family of low-rank matrix approximations as PCA and provides fairly similar results. We showcase the ADI capabilities of the VIP library using a deep sequence on HR 8799 taken with the LBTI/LMIRCam and its recently commissioned L-band vortex coronagraph. Using VIP, we investigated the presence of additional companions around HR 8799 and did not find any significant additional point source beyond the four known planets. VIP is available at http://github.com/vortex-exoplanet/VIP and is accompanied with Jupyter notebook tutorials illustrating the main functionalities of the library.

Managing Digital Archives Using Open Source Software Tools

NASA Astrophysics Data System (ADS)

Barve, S.; Dongare, S.

2007-10-01

This paper describes the use of open source software tools such as MySQL and PHP for creating database-backed websites. Such websites offer many advantages over ones built from static HTML pages. This paper will discuss how OSS tools are used and their benefits, and after the successful implementation of these tools how the library took the initiative in implementing an institutional repository using DSpace open source software.

Implications of Transaction Costs for Acquisition Program Cost Breaches

DTIC Science & Technology

2013-06-01

scope of the work, communicating the basis on which the estimate is built, identifying the quality of the data, determining the level of risk, and...projects such as bases, schools, missile storage facilities, maintenance facilities, medical/ dental clinics, libraries, and military family housing...was established as a threshold for measuring cost growth. This prevents a program from rebaselining to avoid a Nunn- McCurdy cost threshold breach. In

Public Relations in Special Libraries.

ERIC Educational Resources Information Center

Rutkowski, Hollace Ann; And Others

1991-01-01

This theme issue includes 11 articles on public relations (PR) in special libraries. Highlights include PR at the Special Libraries Association (SLA); sources for marketing research for libraries; developing a library image; sample PR releases; brand strategies for libraries; case studies; publicizing a consortium; and a bibliography of pertinent…

Mineral Information Extraction Based on GAOFEN-5'S Thermal Infrared Data

NASA Astrophysics Data System (ADS)

Liu, L.; Shang, K.

2018-04-01

Gaofen-5 carries six instruments aimed at various land and atmosphere applications, and it's an important unit of China High-resolution Earth Observation System. As Gaofen-5's thermal infrared payload is similar to that of ASTER, which is widely used in mineral exploration, application of Gaofen-5's thermal infrared data is discussed regarding its capability in mineral classification and silica content estimation. First, spectra of silicate, carbonate, sulfate minerals from a spectral library are used to conduct spectral feature analysis on Gaofen-5's thermal infrared emissivities. Spectral indices of band emissivities are proposed, and by setting thresholds of these spectral indices, it can classify three types of minerals mentioned above. This classification method is tested on a simulated Gaofen-5 emissivity image. With samples acquired from the study area, this method is proven to be feasible. Second, with band emissivities of silicate and their silica content from the same spectral library, correlation models have been tried to be built for silica content inversion. However, the highest correlation coefficient is merely 0.592, which is much lower than that of correlation model built on ASTER thermal infrared emissivity. It can be concluded that GF-5's thermal infrared data can be utilized in mineral classification but not in silica content inversion.

SOGC–GOC–SCC Joint Policy Statement. No. 255, March 2011. Cervical cancer prevention in low-resource settings.

PubMed

Elit, Laurie; Jimenez, Waldo; McAlpine, Jessica; Ghatage, Prafull; Miller, Dianne; Plante, Marie

2011-03-01

To help care providers understand the current status of cervical cancer in low-resource countries. The most effective and practical options for cervical screening and treatment in low-resource countries are evaluated. Improvement in rates of prevention and early detection of cervical cancer in low-resource countries. PubMed or Medline, CINAHL, and The Cochrane Library were searched for studies published in English between January 2006 and December 2009. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies. The quality of evidence was rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care. Recommendations for practice were ranked according to the method described in that report (Table). RECOMMENDATIONS 1. All girls 9 years old or over should have access to the cervical cancer vaccine before they become sexually active. (I-A) 2. Cervical cancer screening by visual inspection with acetic acid is suggested for low-resource settings acceptable. Cervical cytology or human papillomavirus testing may also be used when practical. (II-2B) 3. Cryotherapy is a safe, effective, and low-cost therapy that should be included in pre-invasive cervical cancer treatment. (III-B) 4. All countries should have a documented cervical cancer prevention strategy that includes public education built on existing outreach programs. (III-C) 5. Countries should define a centre or centres of excellence for the management of cervical cancer. (III-C) Because these units would serve a larger population, they would be able to identify leaders and develop their skills, and would be able to invest in costly radiation equipment. 6. All women with cervical cancer should have access to pain management. (III-C).

In Silico Studies of the Toxcast Chemicals Interacting with Biomolecular targets

EPA Science Inventory

Molecular docking, a structure-based in silico tool for chemical library pre-screening in drug discovery, can be used to explore the potential toxicity of environmental chemicals acting at specific biomelcular targets.

International Reports. International Federation of Library Associations and Institutions; Canada's Libraries in 2002: A Year of Partnerships; A Golden Celebration: The National Library of Canada at 50.

ERIC Educational Resources Information Center

Wiggins, Beacher; Adams, Karen G.; Starr, Mary Jane

2003-01-01

These three reports discuss international library organization issues, including awards and grants, digital technology, and membership; and Canadian library issues, including federal information policy issues, library services, projected shortage of librarians, mergers, digital divide, and a history of the National Library of Canada. (LRW)

Heating and current drive on NSTX

NASA Astrophysics Data System (ADS)

Wilson, J. R.; Batchelor, D.; Carter, M.; Hosea, J.; Ignat, D.; LeBlanc, B.; Majeski, R.; Ono, M.; Phillips, C. K.; Rogers, J. H.; Schilling, G.

1997-04-01

Low aspect ratio tokamaks pose interesting new challenges for heating and current drive. The NSTX (National Spherical Tokamak Experiment) device to be built at Princeton is a low aspect ratio toroidal device that has the achievement of high toroidal beta (˜45%) and non-inductive operation as two of its main research goals. To achieve these goals significant auxiliary heating and current drive systems are required. Present plans include ECH (Electron cyclotron heating) for pre-ionization and start-up assist, HHFW (high harmonic fast wave) for heating and current drive and eventually NBI (neutral beam injection) for heating, current drive and plasma rotation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ronald W.

With the addition of the 3D volume slicer widget, VERAView now relies on Mayavi and its dependents. Enthought's Canopy Python environment provides everything VERAView needs, and pre-built Canopy versions for Windows, Mac OSX, and Linux can be downloaded.

Arkansas People Participating in Lead Education (APPLE): results of a lead-safe training program.

PubMed

Ferguson, Alesia; Bursac, Zoran; Kern, David F

2011-06-01

Lead is still seen as one of the most harmful environmental toxins for young children, with the predominant source being deteriorating lead-based paint. Those at continued risk include those living in homes built before 1978, renovators and remodelers, and especially those with limited access to proper healthcare and diets. Proper training on lead-safe work practices focused on preventing and reducing the spread of lead dust can help reduce lead exposure. Presented in this paper are experiences in delivering lead-safe work practices training in six Arkansas cities, and results from pre- and post- surveys delivered before and immediately after the training. Pre- and post-surveys assess strong and weak areas of training. Participants demonstrated positive shifts in attitude and behavior towards lead-safe work practices following training. However, our research found that more emphasis should be focused on clarifying current lead exposure sources and routes for children.

Ultrafast pre-breakdown dynamics in Al₂O₃SiO₂ reflector by femtosecond UV laser spectroscopy.

PubMed

Du, Juan; Li, Zehan; Xue, Bing; Kobayashi, Takayoshi; Han, Dongjia; Zhao, Yuanan; Leng, Yuxin

2015-06-29

Ultrafast carrier dynamics in Al2O3/SiO2 high reflectors has been investigated by UV femtosecond laser. It is identified by laser spectroscopy that, the carrier dynamics contributed from the front few layers of Al2O3 play a dominating role in the initial laser-induced damage of the UV reflector. Time-resolved reflection decrease after the UV excitation is observed, and conduction electrons is found to relaxed to a mid-gap defect state locating about one photon below the conduction band . To interpret the laser induced carrier dynamics further, a theoretical model including electrons relaxation to a mid-gap state is built, and agrees very well with the experimental results.. To the best of our knowledge, this is the first study on the pre-damage dynamics in UV high reflector induced by femtosecond UV laser.

Enterprise Reference Library

NASA Technical Reports Server (NTRS)

Bickham, Grandin; Saile, Lynn; Havelka, Jacque; Fitts, Mary

2011-01-01

Introduction: Johnson Space Center (JSC) offers two extensive libraries that contain journals, research literature and electronic resources. Searching capabilities are available to those individuals residing onsite or through a librarian s search. Many individuals have rich collections of references, but no mechanisms to share reference libraries across researchers, projects, or directorates exist. Likewise, information regarding which references are provided to which individuals is not available, resulting in duplicate requests, redundant labor costs and associated copying fees. In addition, this tends to limit collaboration between colleagues and promotes the establishment of individual, unshared silos of information The Integrated Medical Model (IMM) team has utilized a centralized reference management tool during the development, test, and operational phases of this project. The Enterprise Reference Library project expands the capabilities developed for IMM to address the above issues and enhance collaboration across JSC. Method: After significant market analysis for a multi-user reference management tool, no available commercial tool was found to meet this need, so a software program was built around a commercial tool, Reference Manager 12 by The Thomson Corporation. A use case approach guided the requirements development phase. The premise of the design is that individuals use their own reference management software and export to SharePoint when their library is incorporated into the Enterprise Reference Library. This results in a searchable user-specific library application. An accompanying share folder will warehouse the electronic full-text articles, which allows the global user community to access full -text articles. Discussion: An enterprise reference library solution can provide a multidisciplinary collection of full text articles. This approach improves efficiency in obtaining and storing reference material while greatly reducing labor, purchasing and duplication costs. Most importantly, increasing collaboration across research groups provides unprecedented access to information relevant to NASA s mission. Conclusion: This project is an expansion and cost-effective leveraging of the existing JSC centralized library. Adding key word and author search capabilities and an alert function for notifications about new articles, based on users profiles, represent examples of future enhancements.

The Engineering and Science Issues Test (ESIT): a discipline-specific approach to assessing moral judgment.

PubMed

Borenstein, Jason; Drake, Matthew J; Kirkman, Robert; Swann, Julie L

2010-06-01

To assess ethics pedagogy in science and engineering, we developed a new tool called the Engineering and Science Issues Test (ESIT). ESIT measures moral judgment in a manner similar to the Defining Issues Test, second edition, but is built around technical dilemmas in science and engineering. We used a quasi-experimental approach with pre- and post-tests, and we compared the results to those of a control group with no overt ethics instruction. Our findings are that several (but not all) stand-alone classes showed a significant improvement compared to the control group when the metric includes multiple stages of moral development. We also found that the written test had a higher response rate and sensitivity to pedagogy than the electronic version. We do not find significant differences on pre-test scores with respect to age, education level, gender or political leanings, but we do on whether subjects were native English speakers. We did not find significant differences on pre-test scores based on whether subjects had previous ethics instruction; this could suggest a lack of a long-term effect from the instruction.

IFLA General Conference, 1992. Division of Libraries Serving the General Public: Section on Library Services to Multicultural Populations; Section on School Libraries; Section on Public Libraries. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, London (England).

Eleven papers delivered for the Division of Libraries Serving the General Public at the International Federation of Library Associations and Institutions 1992 annual meeting are presented. Most deal with library services to multicultural populations, including those of developing countries. The following papers are included: (1) "Library…

Character Education Connections for School, Home and Community: A Guide for Integrating Character Education. Grades Pre-K through 12. 2nd Edition.

ERIC Educational Resources Information Center

Stirling, Diane

This character education guide, for grades Pre-K through 12, presents field-generated, field-tested ideas for integrating character education with daily learning. The ideas are varied in design, scope, and developmental levels and range from half-hour lessons to school-wide events to year-long courses. Each unit (50 in all) is built on particular…

Character Education Connections for School, Home and Community: A Guide for Integrating Character Education. Grades Pre-K through 12. Revised 2002. Third Edition.

ERIC Educational Resources Information Center

Stirling, Diane

This character-education guide, for grades Pre-K through 12, presents field-generated, field-tested ideas for integrating character education with daily learning. The ideas are varied in design, scope, and developmental levels, and range from half-hour lessons to schoolwide events to year-long courses. Each unit (50 in all) is built on particular…

acme: The Amendable Coal-Fire Modeling Exercise. A C++ Class Library for the Numerical Simulation of Coal-Fires

NASA Astrophysics Data System (ADS)

Wuttke, Manfred W.

2017-04-01

At LIAG, we use numerical models to develop and enhance understanding of coupled transport processes and to predict the dynamics of the system under consideration. Topics include geothermal heat utilization, subrosion processes, and spontaneous underground coal fires. Although the details make it inconvenient if not impossible to apply a single code implementation to all systems, their investigations go along similar paths: They all depend on the solution of coupled transport equations. We thus saw a need for a modular code system with open access for the various communities to maximize the shared synergistic effects. To this purpose we develop the oops! ( open object-oriented parallel solutions) - toolkit, a C++ class library for the numerical solution of mathematical models of coupled thermal, hydraulic and chemical processes. This is used to develop problem-specific libraries like acme( amendable coal-fire modeling exercise), a class library for the numerical simulation of coal-fires and applications like kobra (Kohlebrand, german for coal-fire), a numerical simulation code for standard coal-fire models. Basic principle of the oops!-code system is the provision of data types for the description of space and time dependent data fields, description of terms of partial differential equations (pde), their discretisation and solving methods. Coupling of different processes, described by their particular pde is modeled by an automatic timescale-ordered operator-splitting technique. acme is a derived coal-fire specific application library, depending on oops!. If specific functionalities of general interest are implemented and have been tested they will be assimilated into the main oops!-library. Interfaces to external pre- and post-processing tools are easily implemented. Thus a construction kit which can be arbitrarily amended is formed. With the kobra-application constructed with acme we study the processes and propagation of shallow coal seam fires in particular in Xinjiang, China, as well as analyze and interpret results from lab experiments.

Library/Information Science Education, Placement, and Salaries.

ERIC Educational Resources Information Center

Davis, Darlena; Gregory, Vicki L.; Wohlmuth, Sonia Ramirez

2001-01-01

Includes five articles: a guide to employment sources in the library and information professions, including the Internet, library joblines, specialized associations, state agencies, and overseas exchange programs; placements and salaries in 1999; accredited master's programs in library and information studies; library scholarship sources; and…

Library Employment Sources on the Internet

ERIC Educational Resources Information Center

Barr, Catherine

2012-01-01

This article presents a list of online resources for library job seekers. This includes general sites/portals like American Library Association (ALA): Education & Careers and Canadian Library Association: Library Careers. It also includes sites by sector, employment agencies/commercial services, listservs and networking sites.

Upsize This! Libraries Need Relationship Marketing.

ERIC Educational Resources Information Center

Besant, Larry X.; Sharp, Deborah

2000-01-01

Describes relationship marketing, which emphasizes customers, and explains why libraries should be interested in it. Topics include the lack of marketing that libraries have done; creating new paradigms for marketing; and various markets that libraries should address, including the users, library employees, and suppliers. (LRW)

Florida: Library Networking and Technology Development.

ERIC Educational Resources Information Center

Wilkins, Barratt, Ed.

1996-01-01

Explains the development of library networks in Florida and the role of the state library. Topics include regional multitype library consortia; a statewide bibliographic database; interlibrary loan; Internet access in public libraries; government information, including remote public access; automation projects; telecommunications; and free-nets.…

IFLA General Conference, 1985. Division on Libraries Serving the General Public. Section on Public Libraries. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

This document includes papers on public libraries which were presented at the 1985 International Federation of Library Associations (IFLA) conference. The first paper, "International Guidelines for Public Libraries," is the report of an IFLA working group and it includes guidelines in six areas: public library services; media of…

The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting: a systematic review of the literature.

PubMed

Goodwin, Nicholas S; Spinks, Anneliese; Wasiak, Jason

2016-08-01

The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language articles published through September 2014. Reference lists, conference proceedings and non-indexed academic journals were manually searched. A separate search was conducted using the Internet search engine Google to source additional studies from burns advisory agencies, first aid bodies, military institutions, manufacturer and paramedic websites. Two authors independently assessed study eligibility and relevance of non-traditional data forms for inclusion. Studies were independently assessed and included if Hydrogel-based burn dressings (HBD) were examined in first aid practices in the pre-hospital setting. A total of 129 studies were considered for inclusion, of which no pre-hospital studies were identified. The review highlights that current use of HBD in the pre-hospital setting appears to be driven by sources of information that do not reflect the paramedic environment. We recommend researchers in the pre-hospital settings undertake clinical trials in this field. More so, the review supports the need for expert consensus to identify key demographic, clinical and injury outcomes for clinicians and researchers undertaking further research into the use of dressings as a first aid measure. © 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

QUICK - AN INTERACTIVE SOFTWARE ENVIRONMENT FOR ENGINEERING DESIGN

NASA Technical Reports Server (NTRS)

Schlaifer, R. S.

1994-01-01

QUICK provides the computer user with the facilities of a sophisticated desk calculator which can perform scalar, vector and matrix arithmetic, propagate conic orbits, determine planetary and satellite coordinates and perform other related astrodynamic calculations within a Fortran-like environment. QUICK is an interpreter, therefore eliminating the need to use a compiler or a linker to run QUICK code. QUICK capabilities include options for automated printing of results, the ability to submit operating system commands on some systems, and access to a plotting package (MASL)and a text editor without leaving QUICK. Mathematical and programming features of QUICK include the ability to handle arbitrary algebraic expressions, the capability to define user functions in terms of other functions, built-in constants such as pi, direct access to useful COMMON areas, matrix capabilities, extensive use of double precision calculations, and the ability to automatically load user functions from a standard library. The MASL (The Multi-mission Analysis Software Library) plotting package, included in the QUICK package, is a set of FORTRAN 77 compatible subroutines designed to facilitate the plotting of engineering data by allowing programmers to write plotting device independent applications. Its universality lies in the number of plotting devices it puts at the user's disposal. The MASL package of routines has proved very useful and easy to work with, yielding good plots for most new users on the first or second try. The functions provided include routines for creating histograms, "wire mesh" surface plots and contour plots as well as normal graphs with a large variety of axis types. The library has routines for plotting on cartesian, polar, log, mercator, cyclic, calendar, and stereographic axes, and for performing automatic or explicit scaling. The lengths of the axes of a plot are completely under the control of the program using the library. Programs written to use the MASL subroutines can be made to output to the Calcomp 1055 plotter, the Hewlett-Packard 2648 graphics terminal, the HP 7221, 7475 and 7550 pen plotters, the Tektronix 40xx and 41xx series graphics terminals, the DEC VT125/VT240 graphics terminals, the QMS 800 laser printer, the Sun Microsystems monochrome display, the Ridge Computers monochrome display, the IBM/PC color display, or a "dumb" terminal or printer. Programs using this library can be written so that they always use the same type of plotter or they can allow the choice of plotter type to be deferred until after program execution. QUICK is written in RATFOR for use on Sun4 series computers running SunOS. No source code is provided. The standard distribution medium for this program is a .25 inch streaming magnetic tape cartridge in UNIX tar format. An electronic copy of the documentation in ASCII format is included on the distribution medium. QUICK was developed in 1991 and is a copyrighted work with all copyright vested in NASA.

Interactive Light Stimulus Generation with High Performance Real-Time Image Processing and Simple Scripting.

PubMed

Szécsi, László; Kacsó, Ágota; Zeck, Günther; Hantz, Péter

2017-01-01

Light stimulation with precise and complex spatial and temporal modulation is demanded by a series of research fields like visual neuroscience, optogenetics, ophthalmology, and visual psychophysics. We developed a user-friendly and flexible stimulus generating framework (GEARS GPU-based Eye And Retina Stimulation Software), which offers access to GPU computing power, and allows interactive modification of stimulus parameters during experiments. Furthermore, it has built-in support for driving external equipment, as well as for synchronization tasks, via USB ports. The use of GEARS does not require elaborate programming skills. The necessary scripting is visually aided by an intuitive interface, while the details of the underlying software and hardware components remain hidden. Internally, the software is a C++/Python hybrid using OpenGL graphics. Computations are performed on the GPU, and are defined in the GLSL shading language. However, all GPU settings, including the GPU shader programs, are automatically generated by GEARS. This is configured through a method encountered in game programming, which allows high flexibility: stimuli are straightforwardly composed using a broad library of basic components. Stimulus rendering is implemented solely in C++, therefore intermediary libraries for interfacing could be omitted. This enables the program to perform computationally demanding tasks like en-masse random number generation or real-time image processing by local and global operations.

Dynamic Modeling and Soil Mechanics for Path Planning of the Mars Exploration Rovers

NASA Technical Reports Server (NTRS)

Trease, Brian

2011-01-01

To help minimize risk of high sinkage and slippage during drives and to better understand soil properties and rover terramechanics from drive data, a multidisciplinary team was formed under the Mars Exploration Rover project to develop and utilize dynamic computer-based models for rover drives over realistic terrains. The resulting system, named ARTEMIS (Adams-based Rover Terramechanics and Mobility Interaction System), consists of the dynamic model, a library of terramechanics subroutines, and the high-resolution digital elevation maps of the Mars surface. A 200-element model of the rovers was developed and validated for drop tests before launch, using Adams dynamic modeling software. The external library was built in Fortran and called by Adams to model the wheel-soil interactions include the rut-formation effect of deformable soils, lateral and longitudinal forces, bull-dozing effects, and applied wheel torque. The paper presents the details and implementation of the system. To validate the developed system, one study case is presented from a realistic drive on Mars of the Opportunity rover. The simulation results match well from the measurement of on-board telemetry data. In its final form, ARTEMIS will be used in a predictive manner to assess terrain navigability and will become part of the overall effort in path planning and navigation for both Martian and lunar rovers.

Lowering the Barrier to Reproducible Research by Publishing Provenance from Common Analytical Tools

NASA Astrophysics Data System (ADS)

Jones, M. B.; Slaughter, P.; Walker, L.; Jones, C. S.; Missier, P.; Ludäscher, B.; Cao, Y.; McPhillips, T.; Schildhauer, M.

2015-12-01

Scientific provenance describes the authenticity, origin, and processing history of research products and promotes scientific transparency by detailing the steps in computational workflows that produce derived products. These products include papers, findings, input data, software products to perform computations, and derived data and visualizations. The geosciences community values this type of information, and, at least theoretically, strives to base conclusions on computationally replicable findings. In practice, capturing detailed provenance is laborious and thus has been a low priority; beyond a lab notebook describing methods and results, few researchers capture and preserve detailed records of scientific provenance. We have built tools for capturing and publishing provenance that integrate into analytical environments that are in widespread use by geoscientists (R and Matlab). These tools lower the barrier to provenance generation by automating capture of critical information as researchers prepare data for analysis, develop, test, and execute models, and create visualizations. The 'recordr' library in R and the `matlab-dataone` library in Matlab provide shared functions to capture provenance with minimal changes to normal working procedures. Researchers can capture both scripted and interactive sessions, tag and manage these executions as they iterate over analyses, and then prune and publish provenance metadata and derived products to the DataONE federation of archival repositories. Provenance traces conform to the ProvONE model extension of W3C PROV, enabling interoperability across tools and languages. The capture system supports fine-grained versioning of science products and provenance traces. By assigning global identifiers such as DOIs, reseachers can cite the computational processes used to reach findings. And, finally, DataONE has built a web portal to search, browse, and clearly display provenance relationships between input data, the software used to execute analyses and models, and derived data and products that arise from these computations. This provenance is vital to interpretation and understanding of science, and provides an audit trail that researchers can use to understand and replicate computational workflows in the geosciences.

Development and Validation of a Prototype Vacuum Sensing Unit for the DD2011 Chairside Amalgam Separators

DTIC Science & Technology

2015-10-30

pressure values onto the SD card. The addition of free and open-source Arduino libraries allowed for the seamless integration of the shield into the...alert the user when replacing the separator is necessary. Methods: A sensor was built to measure and record differential pressure values within the...from the transducers during simulated blockages were transformed into pressure values using linear regression equations from the calibration data

Suitability of Unidata Metapps for Incorporation in Platform-Independent User-Customized Aviation Weather Products Generation Software

DTIC Science & Technology

2002-03-08

Figure 7. Standard, simplified view of the Facade software design pattern. Adapted from an original diagram by Shalloway and Trott (Shalloway...and Trott , 2002). 31 set of interfaces. The motivation behind using this design pattern is that it helps reduce complexity and minimizes the...libraries and in turn built more complex components. Although brave and innovative , these forays into the cutting edge of geophysical

Development of SRS.php, a Simple Object Access Protocol-based library for data acquisition from integrated biological databases.

PubMed

Barbosa-Silva, A; Pafilis, E; Ortega, J M; Schneider, R

2007-12-11

Data integration has become an important task for biological database providers. The current model for data exchange among different sources simplifies the manner that distinct information is accessed by users. The evolution of data representation from HTML to XML enabled programs, instead of humans, to interact with biological databases. We present here SRS.php, a PHP library that can interact with the data integration Sequence Retrieval System (SRS). The library has been written using SOAP definitions, and permits the programmatic communication through webservices with the SRS. The interactions are possible by invoking the methods described in WSDL by exchanging XML messages. The current functions available in the library have been built to access specific data stored in any of the 90 different databases (such as UNIPROT, KEGG and GO) using the same query syntax format. The inclusion of the described functions in the source of scripts written in PHP enables them as webservice clients to the SRS server. The functions permit one to query the whole content of any SRS database, to list specific records in these databases, to get specific fields from the records, and to link any record among any pair of linked databases. The case study presented exemplifies the library usage to retrieve information regarding registries of a Plant Defense Mechanisms database. The Plant Defense Mechanisms database is currently being developed, and the proposal of SRS.php library usage is to enable the data acquisition for the further warehousing tasks related to its setup and maintenance.

High precision series solutions of differential equations: Ordinary and regular singular points of second order ODEs

NASA Astrophysics Data System (ADS)

Noreen, Amna; Olaussen, Kåre

2012-10-01

A subroutine for a very-high-precision numerical solution of a class of ordinary differential equations is provided. For a given evaluation point and equation parameters the memory requirement scales linearly with precision P, and the number of algebraic operations scales roughly linearly with P when P becomes sufficiently large. We discuss results from extensive tests of the code, and how one, for a given evaluation point and equation parameters, may estimate precision loss and computing time in advance. Program summary Program title: seriesSolveOde1 Catalogue identifier: AEMW_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEMW_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 991 No. of bytes in distributed program, including test data, etc.: 488116 Distribution format: tar.gz Programming language: C++ Computer: PC's or higher performance computers. Operating system: Linux and MacOS RAM: Few to many megabytes (problem dependent). Classification: 2.7, 4.3 External routines: CLN — Class Library for Numbers [1] built with the GNU MP library [2], and GSL — GNU Scientific Library [3] (only for time measurements). Nature of problem: The differential equation -s2({d2}/{dz2}+{1-ν+-ν-}/{z}{d}/{dz}+{ν+ν-}/{z2})ψ(z)+{1}/{z} ∑n=0N vnznψ(z)=0, is solved numerically to very high precision. The evaluation point z and some or all of the equation parameters may be complex numbers; some or all of them may be represented exactly in terms of rational numbers. Solution method: The solution ψ(z), and optionally ψ'(z), is evaluated at the point z by executing the recursion A(z)={s-2}/{(m+1+ν-ν+)(m+1+ν-ν-)} ∑n=0N Vn(z)A(z), ψ(z)=ψ(z)+A(z), to sufficiently large m. Here ν is either ν+ or ν-, and Vn(z)=vnz. The recursion is initialized by A(z)=δzν,for n=0,1,…,N ψ(z)=A0(z). Restrictions: No solution is computed if z=0, or s=0, or if ν=ν- (assuming Reν+≥Reν-) with ν+-ν- an integer, except when ν+-ν-=1 and v =0 (i.e. when z is an ordinary point for zψ(z)). Additional comments: The code of the main algorithm is in the file seriesSolveOde1.cc, which "#include" the file checkForBreakOde1.cc. These routines, and the programs using them, must "#include" the file seriesSolveOde1.cc. Running time: On a Linux PC that is a few years old, at y=√{10} to an accuracy of P=200 decimal digits, evaluating the ground state wavefunction of the anharmonic oscillator (with the eigenvalue known in advance); (cf. Eq. (6)) takes about 2 ms, and about 40 min at an accuracy of P=100000 decimal digits. References: [1] B. Haible and R.B. Kreckel, CLN — Class Library for Numbers, http://www.ginac.de/CLN/ [2] T. Granlund and collaborators, GMP — The GNU Multiple Precision Arithmetic Library, http://gmplib.org/ [3] M. Galassi et al., GNU Scientific Library Reference Manual (3rd Ed.), ISBN 0954612078., http://www.gnu.org/software/gsl/

Umberto Eco on Libraries: A Discussion of "De Biblioteca."

ERIC Educational Resources Information Center

Winter, Michael F.

1994-01-01

Discusses a scholar's reactions to libraries made by Umberto Eco in "De Biblioteca." Topics addressed include functions of libraries, including collecting; accessibility of materials; the scholar's creative use of libraries, and discovering materials not looked for or known about; North American research libraries; photocopying; and…

Library of the Future: Croydon's New Central Library Complex.

ERIC Educational Resources Information Center

Batt, Chris

1993-01-01

A new library and cultural center in Croyden (England) is described. Function-based areas include library, administration, technical services, museum and galleries, museum offices and store, cinema, tourist information center, and local government offices. Information technology systems include the library management system, office automation, and…

47 CFR 54.511 - Ordering services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... eligible services shall not charge schools, school districts, libraries, library consortia, or consortia... under § 54.501 or consortium that includes an eligible school or library and a service provider shall be... December 31, 1998. (2) For a school, library, or consortium that includes an eligible school or library...

Fifty Years of Promoting Library History: A Chronology of the ALA (American) Library History Round Table, 1947-1997.

ERIC Educational Resources Information Center

Wertheimer, Andrew B.; Marshall, John David

2000-01-01

Presents a chronology of the Library History Round Table of the American Library Association. Includes topics and presenters of programs; awards, including the Justin Winsor Prize and the Phyllis Dain Library Dissertation Award; and leadership. (LRW)

Multifunctional microcontrollable interface module

NASA Astrophysics Data System (ADS)

Spitzer, Mark B.; Zavracky, Paul M.; Rensing, Noa M.; Crawford, J.; Hockman, Angela H.; Aquilino, P. D.; Girolamo, Henry J.

2001-08-01

This paper reports the development of a complete eyeglass- mounted computer interface system including display, camera and audio subsystems. The display system provides an SVGA image with a 20 degree horizontal field of view. The camera system has been optimized for face recognition and provides a 19 degree horizontal field of view. A microphone and built-in pre-amp optimized for voice recognition and a speaker on an articulated arm are included for audio. An important feature of the system is a high degree of adjustability and reconfigurability. The system has been developed for testing by the Military Police, in a complete system comprising the eyeglass-mounted interface, a wearable computer, and an RF link. Details of the design, construction, and performance of the eyeglass-based system are discussed.

Health sciences library building projects, 1998 survey.

PubMed Central

Bowden, V M

1999-01-01

Twenty-eight health sciences library building projects are briefly described, including twelve new buildings and sixteen additions, remodelings, and renovations. The libraries range in size from 2,144 square feet to 190,000 gross square feet. Twelve libraries are described in detail. These include three hospital libraries, one information center sponsored by ten institutions, and eight academic health sciences libraries. Images PMID:10550027

The Whole Library Handbook 3: Current Data, Professional Advice, and Curiosa about Libraries and Library Services.

ERIC Educational Resources Information Center

Eberhart, George M., Comp.

This handbook contains articles, guidelines, and other information from the field of library science organized into the following chapters: (1) "Libraries," including some basic figures, academic libraries, public libraries, school libraries, special libraries, national libraries, state libraries, small libraries, facilities, the past, and the…

Do changes to the local street environment alter behaviour and quality of life of older adults? The 'DIY Streets' intervention.

PubMed

Ward Thompson, Catharine; Curl, Angela; Aspinall, Peter; Alves, Susana; Zuin, Affonso

2014-07-01

The burden of ill-health due to inactivity has recently been highlighted. Better studies on environments that support physical activity are called for, including longitudinal studies of environmental interventions. A programme of residential street improvements in the UK (Sustrans 'DIY Streets') allowed a rare opportunity for a prospective, longitudinal study of the effect of such changes on older adults' activities, health and quality of life. Pre-post, cross-sectional surveys were carried out in locations across England, Wales and Scotland; participants were aged 65+ living in intervention or comparison streets. A questionnaire covered health and quality of life, frequency of outdoor trips, time outdoors in different activities and a 38-item scale on neighbourhood open space. A cohort study explored changes in self-report activity and well-being postintervention. Activity levels were also measured by accelerometer and accompanying diary records. The cross-sectional surveys showed outdoor activity predicted by having a clean, nuisance-free local park, attractive, barrier-free routes to it and other natural environments nearby. Being able to park one's car outside the house also predicted time outdoors. The environmental changes had an impact on perceptions of street walkability and safety at night, but not on overall activity levels, health or quality of life. Participants' moderate-to-vigorous activity levels rarely met UK health recommendations. Our study contributes to methodology in a longitudinal, pre-post design and points to factors in the built environment that support active ageing. We include an example of knowledge exchange guidance on age-friendly built environments for policy-makers and planners. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

libRoadRunner: a high performance SBML simulation and analysis library

PubMed Central

Somogyi, Endre T.; Bouteiller, Jean-Marie; Glazier, James A.; König, Matthias; Medley, J. Kyle; Swat, Maciej H.; Sauro, Herbert M.

2015-01-01

Motivation: This article presents libRoadRunner, an extensible, high-performance, cross-platform, open-source software library for the simulation and analysis of models expressed using Systems Biology Markup Language (SBML). SBML is the most widely used standard for representing dynamic networks, especially biochemical networks. libRoadRunner is fast enough to support large-scale problems such as tissue models, studies that require large numbers of repeated runs and interactive simulations. Results: libRoadRunner is a self-contained library, able to run both as a component inside other tools via its C++ and C bindings, and interactively through its Python interface. Its Python Application Programming Interface (API) is similar to the APIs of MATLAB (www.mathworks.com) and SciPy (http://www.scipy.org/), making it fast and easy to learn. libRoadRunner uses a custom Just-In-Time (JIT) compiler built on the widely used LLVM JIT compiler framework. It compiles SBML-specified models directly into native machine code for a variety of processors, making it appropriate for solving extremely large models or repeated runs. libRoadRunner is flexible, supporting the bulk of the SBML specification (except for delay and non-linear algebraic equations) including several SBML extensions (composition and distributions). It offers multiple deterministic and stochastic integrators, as well as tools for steady-state analysis, stability analysis and structural analysis of the stoichiometric matrix. Availability and implementation: libRoadRunner binary distributions are available for Mac OS X, Linux and Windows. The library is licensed under Apache License Version 2.0. libRoadRunner is also available for ARM-based computers such as the Raspberry Pi. http://www.libroadrunner.org provides online documentation, full build instructions, binaries and a git source repository. Contacts: hsauro@u.washington.edu or somogyie@indiana.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:26085503

libRoadRunner: a high performance SBML simulation and analysis library.

PubMed

Somogyi, Endre T; Bouteiller, Jean-Marie; Glazier, James A; König, Matthias; Medley, J Kyle; Swat, Maciej H; Sauro, Herbert M

2015-10-15

This article presents libRoadRunner, an extensible, high-performance, cross-platform, open-source software library for the simulation and analysis of models expressed using Systems Biology Markup Language (SBML). SBML is the most widely used standard for representing dynamic networks, especially biochemical networks. libRoadRunner is fast enough to support large-scale problems such as tissue models, studies that require large numbers of repeated runs and interactive simulations. libRoadRunner is a self-contained library, able to run both as a component inside other tools via its C++ and C bindings, and interactively through its Python interface. Its Python Application Programming Interface (API) is similar to the APIs of MATLAB ( WWWMATHWORKSCOM: ) and SciPy ( HTTP//WWWSCIPYORG/: ), making it fast and easy to learn. libRoadRunner uses a custom Just-In-Time (JIT) compiler built on the widely used LLVM JIT compiler framework. It compiles SBML-specified models directly into native machine code for a variety of processors, making it appropriate for solving extremely large models or repeated runs. libRoadRunner is flexible, supporting the bulk of the SBML specification (except for delay and non-linear algebraic equations) including several SBML extensions (composition and distributions). It offers multiple deterministic and stochastic integrators, as well as tools for steady-state analysis, stability analysis and structural analysis of the stoichiometric matrix. libRoadRunner binary distributions are available for Mac OS X, Linux and Windows. The library is licensed under Apache License Version 2.0. libRoadRunner is also available for ARM-based computers such as the Raspberry Pi. http://www.libroadrunner.org provides online documentation, full build instructions, binaries and a git source repository. hsauro@u.washington.edu or somogyie@indiana.edu Supplementary data are available at Bioinformatics online. Published by Oxford University Press 2015. This work is written by US Government employees and is in the public domain in the US.

Fundamentals of the Slide Library.

ERIC Educational Resources Information Center

Boerner, Susan Zee

This paper is an introduction to the fundamentals of the art (including architecture) slide library, with some emphasis on basic procedures of the science slide library. Information in this paper is particularly relevant to the college, university, and museum slide library. Topics addressed include: (1) history of the slide library; (2) duties of…

Idaho Library Laws, 1996-1997. Full Edition.

ERIC Educational Resources Information Center

Idaho State Library, Boise.

This new edition of the "Idaho Library Laws" contains changes through the 1996 legislative session and includes "Idaho Code" sections that legally affect city, school-community or district libraries, or the Idaho State Library. These sections include the basic library laws in "Idaho Code" Title 33, Chapters 25, 26,…

Meeting the Information Needs of Interdisciplinary Scholars: Issues for Administrators of Large University Libraries.

ERIC Educational Resources Information Center

Searing, Susan E.

1996-01-01

Provides an overview of administrative issues in supporting interdisciplinary library use at large universities. Topics include information resources; cataloging and classification; library services to users, including library use education and reference services; library organization; the campus context; and the politics of interdisciplinarity.…

Concept of Price in a Library Context.

ERIC Educational Resources Information Center

Talaga, James A.

1991-01-01

Discusses pricing problems of public library service. The meaning of price in a library context is examined, including amount charged and patron's cost; components of price setting are described, including the impact of demand, cost, and competition; and library pricing strategies are suggested that should help achieve the library's goals. (13…

Finding Information on the State Virtual Libraries

ERIC Educational Resources Information Center

Pappas, Marjorie L.

2004-01-01

The number of state virtual libraries is rapidly expanding. These virtual libraries might include collections of subscription databases; state weblinks and resources; digital collections of primary source documents; and a state union catalog or links to school, public, and academic library catalogs. Most of these virtual libraries include an…

Complications to Avoid with Pre-Diabetes

MedlinePlus

... and Live Our Interactive Cardiovascular Library has detailed animations and illustrations to help you learn about conditions, treatments and procedures related to heart disease and stroke. Popular Articles 1 Understanding Blood Pressure Readings 2 Sodium and Salt 3 Heart Attack Symptoms ...

Quality evaluation of tandem mass spectral libraries.

PubMed

Oberacher, Herbert; Weinmann, Wolfgang; Dresen, Sebastian

2011-06-01

Tandem mass spectral libraries are gaining more and more importance for the identification of unknowns in different fields of research, including metabolomics, forensics, toxicology, and environmental analysis. Particularly, the recent invention of reliable, robust, and transferable libraries has increased the general acceptance of these tools. Herein, we report on results obtained from thorough evaluation of the match reliabilities of two tandem mass spectral libraries: the MSforID library established by the Oberacher group in Innsbruck and the Weinmann library established by the Weinmann group in Freiburg. Three different experiments were performed: (1) Spectra of the libraries were searched against their corresponding library after excluding either this single compound-specific spectrum or all compound-specific spectra prior to searching; (2) the libraries were searched against each other using either library as reference set or sample set; (3) spectra acquired on different mass spectrometric instruments were matched to both libraries. Almost 13,000 tandem mass spectra were included in this study. The MSforID search algorithm was used for spectral matching. Statistical evaluation of the library search results revealed that principally both libraries enable the sensitive and specific identification of compounds. Due to higher mass accuracy of the QqTOF compared with the QTrap instrument, matches to the MSforID library were more reliable when comparing spectra with both libraries. Furthermore, only the MSforID library was shown to be efficiently transferable to different kinds of tandem mass spectrometers, including "tandem-in-time" instruments; this is due to the coverage of a large range of different collision energy settings-including the very low range-which is an outstanding characteristics of the MSforID library.

Pre-flight calibration and initial data processing for the ChemCam laser-induced breakdown spectroscopy instrument on the Mars Science Laboratory rover

USGS Publications Warehouse

Wiens, R.C.; Maurice, S.; Lasue, J.; Forni, O.; Anderson, R.B.; Clegg, S.; Bender, S.; Blaney, D.; Barraclough, B.L.; Cousin, A.; DeFlores, L.; Delapp, D.; Dyar, M.D.; Fabre, C.; Gasnault, O.; Lanza, N.; Mazoyer, J.; Melikechi, N.; Meslin, P.-Y.; Newsom, H.; Ollila, A.; Perez, R.; Tokar, R.; Vaniman, D.

2013-01-01

The ChemCam instrument package on the Mars Science Laboratory rover, Curiosity, is the first planetary science instrument to employ laser-induced breakdown spectroscopy (LIBS) to determine the compositions of geological samples on another planet. Pre-processing of the spectra involves subtracting the ambient light background, removing noise, removing the electron continuum, calibrating for the wavelength, correcting for the variable distance to the target, and applying a wavelength-dependent correction for the instrument response. Further processing of the data uses multivariate and univariate comparisons with a LIBS spectral library developed prior to launch as well as comparisons with several on-board standards post-landing. The level-2 data products include semi-quantitative abundances derived from partial least squares regression. A LIBS spectral library was developed using 69 rock standards in the form of pressed powder disks, glasses, and ceramics to minimize heterogeneity on the scale of the observation (350–550 μm dia.). The standards covered typical compositional ranges of igneous materials and also included sulfates, carbonates, and phyllosilicates. The provenance and elemental and mineralogical compositions of these standards are described. Spectral characteristics of this data set are presented, including the size distribution and integrated irradiances of the plasmas, and a proxy for plasma temperature as a function of distance from the instrument. Two laboratory-based clones of ChemCam reside in Los Alamos and Toulouse for the purpose of adding new spectra to the database as the need arises. Sensitivity to differences in wavelength correlation to spectral channels and spectral resolution has been investigated, indicating that spectral registration needs to be within half a pixel and resolution needs to match within 1.5 to 2.6 pixels. Absolute errors are tabulated for derived compositions of each major element in each standard using PLS regression. Sources of errors are investigated and discussed, and methods for improving the analytical accuracy of compositions derived from ChemCam spectra are discussed.

High performance geospatial and climate data visualization using GeoJS

NASA Astrophysics Data System (ADS)

Chaudhary, A.; Beezley, J. D.

2015-12-01

GeoJS (https://github.com/OpenGeoscience/geojs) is an open-source library developed to support interactive scientific and geospatial visualization of climate and earth science datasets in a web environment. GeoJS has a convenient application programming interface (API) that enables users to harness the fast performance of WebGL and Canvas 2D APIs with sophisticated Scalable Vector Graphics (SVG) features in a consistent and convenient manner. We started the project in response to the need for an open-source JavaScript library that can combine traditional geographic information systems (GIS) and scientific visualization on the web. Many libraries, some of which are open source, support mapping or other GIS capabilities, but lack the features required to visualize scientific and other geospatial datasets. For instance, such libraries are not be capable of rendering climate plots from NetCDF files, and some libraries are limited in regards to geoinformatics (infovis in a geospatial environment). While libraries such as d3.js are extremely powerful for these kinds of plots, in order to integrate them into other GIS libraries, the construction of geoinformatics visualizations must be completed manually and separately, or the code must somehow be mixed in an unintuitive way.We developed GeoJS with the following motivations:• To create an open-source geovisualization and GIS library that combines scientific visualization with GIS and informatics• To develop an extensible library that can combine data from multiple sources and render them using multiple backends• To build a library that works well with existing scientific visualizations tools such as VTKWe have successfully deployed GeoJS-based applications for multiple domains across various projects. The ClimatePipes project funded by the Department of Energy, for example, used GeoJS to visualize NetCDF datasets from climate data archives. Other projects built visualizations using GeoJS for interactively exploring data and analysis regarding 1) the human trafficking domain, 2) New York City taxi drop-offs and pick-ups, and 3) the Ebola outbreak. GeoJS supports advanced visualization features such as picking and selecting, as well as clustering. It also supports 2D contour plots, vector plots, heat maps, and geospatial graphs.

Documentation and Monitoring of Built Heritage in Abu Dhabi, Uae

NASA Astrophysics Data System (ADS)

Muhammad, S.

2013-07-01

The ancient oasis-city of Al Ain in Abu Dhabi Emirate still retains the most important and outstanding cultural heritage of United Arab Emirates (UAE). The larger area of Abu Dhabi Emirate comprised of archaeological sites, cultural landscapes and historic buildings dating back to 3rd millennium to the recent pre-oil era. Traditional materials like stone, earth and palm wood were used in combination with local construction methods. For the last seven years the newly formed Abu Dhabi Tourism & Culture Authority (TCA Abu Dhabi)1 has been actively involved in conservation of built heritage in Abu Dhabi Emirate with the help of its Conservation Section. Documentation prior to any conservation and restoration works is considered as a basic pre-requisite for understanding an historic building or site. It is a process which continues during the conservation of any monument and is the only accurate tool for recording information in order to understand the structure, ultimately leading to the management of cultural heritage. Application and use of tools, ranging from basic manual techniques to 3D laser scanning, based on the best practices and international guidelines the exercise will help in establishing a documentation lab with standard procedures, specifications and tools for the documentation and monitoring the built heritage of Abu Dhabi Emirate. This paper will discuss a range of case studies and will demonstrate how documentation and monitoring of the built heritage has augmented the various conservation initiatives on a variety of building types.

Special Problems in the Library Setting.

ERIC Educational Resources Information Center

Keller, Daniel P.

1997-01-01

Discussion of violence in the workplace focuses on libraries. Highlights include types of violence in libraries; recognizing warning signs of employee violence; preventive action; and strategies for a safer library, including appropriate security systems and other devices. (LRW)

Library Functions, Scholarly Communication, and the Foundation of the Digital Library: Laying Claim to the Control Zone.

ERIC Educational Resources Information Center

Atkinson, Ross

1996-01-01

Discussion of academic libraries and online systems focuses on core library services and a digital library which could serve as an alternative publishing mechanism for specialized scholarly communication. Highlights include adding value to sources of information; conflicts, including those with commercial publishers; and standardization and…

Idaho Library Laws, 1999-2000. Full Edition.

ERIC Educational Resources Information Center

Idaho State Library, Boise.

This new edition of the Idaho Library Laws contains changes through the 1998 legislative session and includes Idaho Code sections that legally affect city, school-community or district libraries, or the Idaho State Library. These sections include the basic library laws in Idaho Code Title 33, Chapters 25, 26, and 27, additional sections of the law…

E-Books and New Library Service Models: An Analysis of the Impact of E-Book Technology on Academic Libraries.

ERIC Educational Resources Information Center

Jantz, Ronald

2001-01-01

Analyzes the implications of electronic book technology (e-books) on academic libraries. Discusses new business models for publishers, including self-publishing, Internet publishing, and partnerships with libraries as publishers; impact on library services, including cataloging, circulation, and digital preservation; user benefits; standards;…

EggLib: processing, analysis and simulation tools for population genetics and genomics

PubMed Central

2012-01-01

Background With the considerable growth of available nucleotide sequence data over the last decade, integrated and flexible analytical tools have become a necessity. In particular, in the field of population genetics, there is a strong need for automated and reliable procedures to conduct repeatable and rapid polymorphism analyses, coalescent simulations, data manipulation and estimation of demographic parameters under a variety of scenarios. Results In this context, we present EggLib (Evolutionary Genetics and Genomics Library), a flexible and powerful C++/Python software package providing efficient and easy to use computational tools for sequence data management and extensive population genetic analyses on nucleotide sequence data. EggLib is a multifaceted project involving several integrated modules: an underlying computationally efficient C++ library (which can be used independently in pure C++ applications); two C++ programs; a Python package providing, among other features, a high level Python interface to the C++ library; and the egglib script which provides direct access to pre-programmed Python applications. Conclusions EggLib has been designed aiming to be both efficient and easy to use. A wide array of methods are implemented, including file format conversion, sequence alignment edition, coalescent simulations, neutrality tests and estimation of demographic parameters by Approximate Bayesian Computation (ABC). Classes implementing different demographic scenarios for ABC analyses can easily be developed by the user and included to the package. EggLib source code is distributed freely under the GNU General Public License (GPL) from its website http://egglib.sourceforge.net/ where a full documentation and a manual can also be found and downloaded. PMID:22494792

EggLib: processing, analysis and simulation tools for population genetics and genomics.

PubMed

De Mita, Stéphane; Siol, Mathieu

2012-04-11

With the considerable growth of available nucleotide sequence data over the last decade, integrated and flexible analytical tools have become a necessity. In particular, in the field of population genetics, there is a strong need for automated and reliable procedures to conduct repeatable and rapid polymorphism analyses, coalescent simulations, data manipulation and estimation of demographic parameters under a variety of scenarios. In this context, we present EggLib (Evolutionary Genetics and Genomics Library), a flexible and powerful C++/Python software package providing efficient and easy to use computational tools for sequence data management and extensive population genetic analyses on nucleotide sequence data. EggLib is a multifaceted project involving several integrated modules: an underlying computationally efficient C++ library (which can be used independently in pure C++ applications); two C++ programs; a Python package providing, among other features, a high level Python interface to the C++ library; and the egglib script which provides direct access to pre-programmed Python applications. EggLib has been designed aiming to be both efficient and easy to use. A wide array of methods are implemented, including file format conversion, sequence alignment edition, coalescent simulations, neutrality tests and estimation of demographic parameters by Approximate Bayesian Computation (ABC). Classes implementing different demographic scenarios for ABC analyses can easily be developed by the user and included to the package. EggLib source code is distributed freely under the GNU General Public License (GPL) from its website http://egglib.sourceforge.net/ where a full documentation and a manual can also be found and downloaded.

Libraries on the MOVE.

ERIC Educational Resources Information Center

Edgar, Jim; And Others

1986-01-01

Presents papers from Illinois State Library and Shawnee Library System's "Libraries on the MOVE" conference focusing on how libraries can impact economic/cultural climate of an area. Topics addressed included information services of rural libraries; marketing; rural library development; library law; information access; interagency…

Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search.

PubMed

Li, Tingting; Cao, Jingjing; Li, Zhen; Wang, Xian; He, Pingli

2016-02-01

Broad screening and identification of β-agonists in feed, serum, urine, muscle and liver samples was achieved in a quick and highly sensitive manner using ultra high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) combined with a spectra library search. Solid-phase extraction technology was employed for sample purification and enrichment. After extraction and purification, the samples were analyzed using a Q-Orbitrap high-resolution mass spectrometer under full-scan and data-dependent MS/MS mode. The acquired mass spectra were compared with an in-house library (compound library and MS/MS mass spectral library) built with TraceFinder Software which contained the M/Z of the precursor ion, chemical formula, retention time, character fragment ions and the entire MS/MS spectra of 32 β-agonist standards. Screening was achieved by comparing 5 key mass spectral results and positive matches were marked. Using the developed method, the identification results from 10 spiked samples and 238 actual samples indicated that only 2% of acquired mass spectra produced false identities. The method validation results showed that the limit of detection ranged from 0.021-3.854 μg kg(-1)and 0.015-1.198 ng mL(-1) for solid and liquid samples, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

Union List of Serials in Pacific Island Libraries.

ERIC Educational Resources Information Center

Cohen, Arlene G., Comp.; Yoshida, Patricia, Comp.

This union list contains the serial holdings from Pacific Island libraries, including the University of the South Pacific Library (Fiji), the University of Guam Robert F. Kennedy Library, Guam Public Library, College of Micronesia-FSM Library, College of the Marshall Islands Library, Micronesian Seminar Library, Palau Community College Library,…

Git as an Encrypted Distributed Version Control System

DTIC Science & Technology

2015-03-01

options. The algorithm uses AES- 256 counter mode with an IV derived from SHA -1-HMAC hash (this is nearly identical to the GCM mode discussed earlier...built into the internal structure of Git. Every file in a Git repository is check summed with a SHA -1 hash, a one-way function with arbitrarily long...implementation. Git-encrypt calls OpenSSL cryptography library command line functions. The default cipher used is AES- 256 - Electronic Code Book (ECB), which is

Biofidelic Human Activity Modeling and Simulation with Large Variability

DTIC Science & Technology

2014-11-25

A systematic approach was developed for biofidelic human activity modeling and simulation by using body scan data and motion capture data to...replicate a human activity in 3D space. Since technologies for simultaneously capturing human motion and dynamic shapes are not yet ready for practical use, a...that can replicate a human activity in 3D space with the true shape and true motion of a human. Using this approach, a model library was built to

The Model Analyst’s Toolkit: Scientific Model Development, Analysis, and Validation

DTIC Science & Technology

2013-05-20

Charles River’s Metronome framework. This framework is built on top of the same Equinox libraries that the popular Eclipse Development Environment uses...the names are fully visible (see Figure 8). The Metronome framework also provides functionality for undo and redo, so the user can easily correct...mistakes. Figure 8. Changing Pane sizes and layouts in the new Metronome -enhanced MAT This period, we also improved the MAT project file format so

Chrono: A Parallel Physics Library for Rigid-Body, Flexible-Body, and Fluid Dynamics

DTIC Science & Technology

2013-08-01

big data. Chrono::Render is capable of using 320 cores and is built around Pixar’s RenderMan. All these components combine to produce Chrono, a multi...rather small collection of rigid and/or deformable bodies of complex geometry (hourglass wall, wheel, track shoe, excava- tor blade, dipper ), and a...motivated by the scope of arbitrary data sets and the potentially immense scene complexity that results from big data; REYES, the underlying architecture

Smartphone-Based Cardiac Rehabilitation Program: Feasibility Study.

PubMed

Chung, Heewon; Ko, Hoon; Thap, Tharoeun; Jeong, Changwon; Noh, Se-Eung; Yoon, Kwon-Ha; Lee, Jinseok

2016-01-01

We introduce a cardiac rehabilitation program (CRP) that utilizes only a smartphone, with no external devices. As an efficient guide for cardiac rehabilitation exercise, we developed an application to automatically indicate the exercise intensity by comparing the estimated heart rate (HR) with the target heart rate zone (THZ). The HR is estimated using video images of a fingertip taken by the smartphone's built-in camera. The introduced CRP app includes pre-exercise, exercise with intensity guidance, and post-exercise. In the pre-exercise period, information such as THZ, exercise type, exercise stage order, and duration of each stage are set up. In the exercise with intensity guidance, the app estimates HR from the pulse obtained using the smartphone's built-in camera and compares the estimated HR with the THZ. Based on this comparison, the app adjusts the exercise intensity to shift the patient's HR to the THZ during exercise. In the post-exercise period, the app manages the ratio of the estimated HR to the THZ and provides a questionnaire on factors such as chest pain, shortness of breath, and leg pain during exercise, as objective and subjective evaluation indicators. As a key issue, HR estimation upon signal corruption due to motion artifacts is also considered. Through the smartphone-based CRP, we estimated the HR accuracy as mean absolute error and root mean squared error of 6.16 and 4.30bpm, respectively, with signal corruption due to motion artifacts being detected by combining the turning point ratio and kurtosis.

The association between body-built and injury occurrence in pre-professional ballet dancers - Separated analysis for the injured body-locations.

PubMed

Zaletel, Petra; Sekulić, Damir; Zenić, Nataša; Esco, Michael R; Šajber, Dorica; Kondrič, Miran

2017-02-21

This study has aimed at identifying prevalence of injury-occurrence in 24 pre-professional-ballet-dancers (females, 16-18 years of age), and identifying the associations between the body-built and prevalence of injuries. The sample of variables included: body mass, body height, and 3 somatotype characteristics (mesomorph, ectomorph and endomorph) and data on injuries over the preceding year. Dancers were mostly ectomorphic-mesomorph (endomorphy: 2.6±0.54, mesomorphy: 3.99±0.77, ectomorphy: 3.23±0.54). The most commonly injured locations were the foot (17% of all injuries) and ankle (17%). Majority of the injuries occurred while practising but 37% of hip-injuries occurred while performing. Ankle-injuries resulted in longest absence from ballet. Endomorphy was related to ankle-injury (odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.4-2.3), ectomorphy to foot injury (OR = 1.7, 95% CI: 1.1-2.9), and body-mass to injury to the toes (OR = 1.7, 95% CI: 1.4-3.1). The results of this study allow for recognizing those dancers who are particularly vulnerable to injuries of certain body location. A more profound analysis of the possible mechanisms that lead to hip-injury during performance is needed. Int J Occup Med Environ Health 2017;30(1):151-159. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

EvoBuild: A Quickstart Toolkit for Programming Agent-Based Models of Evolutionary Processes

NASA Astrophysics Data System (ADS)

Wagh, Aditi; Wilensky, Uri

2018-04-01

Extensive research has shown that one of the benefits of programming to learn about scientific phenomena is that it facilitates learning about mechanisms underlying the phenomenon. However, using programming activities in classrooms is associated with costs such as requiring additional time to learn to program or students needing prior experience with programming. This paper presents a class of programming environments that we call quickstart: Environments with a negligible threshold for entry into programming and a modest ceiling. We posit that such environments can provide benefits of programming for learning without incurring associated costs for novice programmers. To make this claim, we present a design-based research study conducted to compare programming models of evolutionary processes with a quickstart toolkit with exploring pre-built models of the same processes. The study was conducted in six seventh grade science classes in two schools. Students in the programming condition used EvoBuild, a quickstart toolkit for programming agent-based models of evolutionary processes, to build their NetLogo models. Students in the exploration condition used pre-built NetLogo models. We demonstrate that although students came from a range of academic backgrounds without prior programming experience, and all students spent the same number of class periods on the activities including the time students took to learn programming in this environment, EvoBuild students showed greater learning about evolutionary mechanisms. We discuss the implications of this work for design research on programming environments in K-12 science education.

Smartphone-Based Cardiac Rehabilitation Program: Feasibility Study

PubMed Central

Chung, Heewon; Yoon, Kwon-Ha; Lee, Jinseok

2016-01-01

We introduce a cardiac rehabilitation program (CRP) that utilizes only a smartphone, with no external devices. As an efficient guide for cardiac rehabilitation exercise, we developed an application to automatically indicate the exercise intensity by comparing the estimated heart rate (HR) with the target heart rate zone (THZ). The HR is estimated using video images of a fingertip taken by the smartphone’s built-in camera. The introduced CRP app includes pre-exercise, exercise with intensity guidance, and post-exercise. In the pre-exercise period, information such as THZ, exercise type, exercise stage order, and duration of each stage are set up. In the exercise with intensity guidance, the app estimates HR from the pulse obtained using the smartphone’s built-in camera and compares the estimated HR with the THZ. Based on this comparison, the app adjusts the exercise intensity to shift the patient’s HR to the THZ during exercise. In the post-exercise period, the app manages the ratio of the estimated HR to the THZ and provides a questionnaire on factors such as chest pain, shortness of breath, and leg pain during exercise, as objective and subjective evaluation indicators. As a key issue, HR estimation upon signal corruption due to motion artifacts is also considered. Through the smartphone-based CRP, we estimated the HR accuracy as mean absolute error and root mean squared error of 6.16 and 4.30bpm, respectively, with signal corruption due to motion artifacts being detected by combining the turning point ratio and kurtosis. PMID:27551969

By-product formation in repetitive PCR amplification of DNA libraries during SELEX.

PubMed

Tolle, Fabian; Wilke, Julian; Wengel, Jesper; Mayer, Günter

2014-01-01

The selection of nucleic acid aptamers is an increasingly important approach to generate specific ligands binding to virtually any molecule of choice. However, selection-inherent amplification procedures are prone to artificial by-product formation that prohibits the enrichment of target-recognizing aptamers. Little is known about the formation of such by-products when employing nucleic acid libraries as templates. We report on the formation of two different forms of by-products, named ladder- and non-ladder-type observed during repetitive amplification in the course of in vitro selection experiments. Based on sequence information and the amplification behaviour of defined enriched nucleic acid molecules we suppose a molecular mechanism through which these amplification by-products are built. Better understanding of these mechanisms might help to find solutions minimizing by-product formation and improving the success rate of aptamer selection.

Interaction of Dams and Landslides--Case Studies and Mitigation

USGS Publications Warehouse

Schuster, Robert L.

2006-01-01

In the first half of the 20th century, engineering geology and geotechnical engineering were in their infancy, and dams were often built where landslides provided valley constrictions, often without expert site investigation. Only the most important projects were subjected to careful geologic examination. Thus, dams were often built without complete understanding of the possible geotechnical problems occurring in foundations or abutments. Most of these dams still exist, although many have undergone costly repairs because of stability or leakage problems. Today, however, every effort is made in the selection of damsites, including those sited on landslides, to provide foundations and abutments that are generally impervious and capable of withstanding the stresses imposed by the proposed dam and reservoir, and possible landslides. By means of a literature search, technical interviews, and field inventory, I have located 254 large (at least 10 m high) dams worldwide that directly interact with landslides; that is, they have been built on pre-existing landslides or have been subjected to landslide activity during or after construction. A table (Appendix table A) summarizes dam characteristics, landslide conditions, and remedial measures at each of the dams. Of the 254 dams, 164 are earthfill, 23 are rockfill, and 18 are earthfill-rockfill; these are flexible dam types that generally perform better on the possibly unstable foundations provided by landslides than do more rigid concrete dams. Any pre-existing landslides that might impinge on the foundation or abutments of a dam should be carefully investigated. If a landslide is recognized in a dam foundation or abutment, the landslide deposits commonly are avoided in siting the dam or are removed during stripping of the dam foundation and abutment contacts. Contrarily, it has often been found to be technically feasible and economically desirable to site and construct dams on known landslides or on the remnants of these features. In these cases, proven preventive and remedial measures have been used to ensure the stability of the foundations and abutments, and to reduce seepage to acceptable levels.

Placement on the Hierarchy.

ERIC Educational Resources Information Center

Woolls, Blanche

1991-01-01

Discusses the image of school library media specialists, particularly their self-image. Topics discussed include reasons for poor self-image; comparisons with other libraries, including number of professionals, education level, and budget; similarities and differences among libraries; and services of school library media centers. (eight…

Library Skills.

ERIC Educational Resources Information Center

Paul, Karin; Kuhlthau, Carol C.; Branch, Jennifer L.; Solowan, Diane Galloway; Case, Roland; Abilock, Debbie; Eisenberg, Michael B.; Koechlin, Carol; Zwaan, Sandi; Hughes, Sandra; Low, Ann; Litch, Margaret; Lowry, Cindy; Irvine, Linda; Stimson, Margaret; Schlarb, Irene; Wilson, Janet; Warriner, Emily; Parsons, Les; Luongo-Orlando, Katherine; Hamilton, Donald

2003-01-01

Includes 19 articles that address issues related to library skills and Canadian school libraries. Topics include information literacy; inquiry learning; critical thinking and electronic research; collaborative inquiry; information skills and the Big 6 approach to problem solving; student use of online databases; library skills; Internet accuracy;…

Cappuccino Bars and Fragrance Gardens.

ERIC Educational Resources Information Center

Hicks, Jack Alan

1994-01-01

Examines the effects of bookstores on public libraries. Topics discussed include the role of libraries as organizers of information; bookstores as competition; reading trends; library collections; libraries' emphasis on user services, including interlibrary loans; partnership programs; marketing strategies; user needs; hours of operation; and…

Distributed Lag Models: Examining Associations between the Built Environment and Health

PubMed Central

Baek, Jonggyu; Sánchez, Brisa N.; Berrocal, Veronica J.; Sanchez-Vaznaugh, Emma V.

2016-01-01

Built environment factors constrain individual level behaviors and choices, and thus are receiving increasing attention to assess their influence on health. Traditional regression methods have been widely used to examine associations between built environment measures and health outcomes, where a fixed, pre-specified spatial scale (e.g., 1 mile buffer) is used to construct environment measures. However, the spatial scale for these associations remains largely unknown and misspecifying it introduces bias. We propose the use of distributed lag models (DLMs) to describe the association between built environment features and health as a function of distance from the locations of interest and circumvent a-priori selection of a spatial scale. Based on simulation studies, we demonstrate that traditional regression models produce associations biased away from the null when there is spatial correlation among the built environment features. Inference based on DLMs is robust under a range of scenarios of the built environment. We use this innovative application of DLMs to examine the association between the availability of convenience stores near California public schools, which may affect children’s dietary choices both through direct access to junk food and exposure to advertisement, and children’s body mass index z-scores (BMIz). PMID:26414942

Titian: Data Provenance Support in Spark

PubMed Central

Interlandi, Matteo; Shah, Kshitij; Tetali, Sai Deep; Gulzar, Muhammad Ali; Yoo, Seunghyun; Kim, Miryung; Millstein, Todd; Condie, Tyson

2015-01-01

Debugging data processing logic in Data-Intensive Scalable Computing (DISC) systems is a difficult and time consuming effort. Today’s DISC systems offer very little tooling for debugging programs, and as a result programmers spend countless hours collecting evidence (e.g., from log files) and performing trial and error debugging. To aid this effort, we built Titian, a library that enables data provenance—tracking data through transformations—in Apache Spark. Data scientists using the Titian Spark extension will be able to quickly identify the input data at the root cause of a potential bug or outlier result. Titian is built directly into the Spark platform and offers data provenance support at interactive speeds—orders-of-magnitude faster than alternative solutions—while minimally impacting Spark job performance; observed overheads for capturing data lineage rarely exceed 30% above the baseline job execution time. PMID:26726305

BgCut: automatic ship detection from UAV images.

PubMed

Xu, Chao; Zhang, Dongping; Zhang, Zhengning; Feng, Zhiyong

2014-01-01

Ship detection in static UAV aerial images is a fundamental challenge in sea target detection and precise positioning. In this paper, an improved universal background model based on Grabcut algorithm is proposed to segment foreground objects from sea automatically. First, a sea template library including images in different natural conditions is built to provide an initial template to the model. Then the background trimap is obtained by combing some templates matching with region growing algorithm. The output trimap initializes Grabcut background instead of manual intervention and the process of segmentation without iteration. The effectiveness of our proposed model is demonstrated by extensive experiments on a certain area of real UAV aerial images by an airborne Canon 5D Mark. The proposed algorithm is not only adaptive but also with good segmentation. Furthermore, the model in this paper can be well applied in the automated processing of industrial images for related researches.

Prototyping a Hybrid Cooperative and Tele-robotic Surgical System for Retinal Microsurgery.

PubMed

Balicki, Marcin; Xia, Tian; Jung, Min Yang; Deguet, Anton; Vagvolgyi, Balazs; Kazanzides, Peter; Taylor, Russell

2011-06-01

This paper presents the design of a tele-robotic microsurgical platform designed for development of cooperative and tele-operative control schemes, sensor based smart instruments, user interfaces and new surgical techniques with eye surgery as the driving application. The system is built using the distributed component-based cisst libraries and the Surgical Assistant Workstation framework. It includes a cooperatively controlled EyeRobot2, a da Vinci Master manipulator, and a remote stereo visualization system. We use constrained optimization based virtual fixture control to provide Virtual Remote-Center-of-Motion (vRCM) and haptic feedback. Such system can be used in a hybrid setup, combining local cooperative control with remote tele-operation, where an experienced surgeon can provide hand-over-hand tutoring to a novice user. In another scheme, the system can provide haptic feedback based on virtual fixtures constructed from real-time force and proximity sensor information.

Prototyping a Hybrid Cooperative and Tele-robotic Surgical System for Retinal Microsurgery

PubMed Central

Balicki, Marcin; Xia, Tian; Jung, Min Yang; Deguet, Anton; Vagvolgyi, Balazs; Kazanzides, Peter; Taylor, Russell

2013-01-01

This paper presents the design of a tele-robotic microsurgical platform designed for development of cooperative and tele-operative control schemes, sensor based smart instruments, user interfaces and new surgical techniques with eye surgery as the driving application. The system is built using the distributed component-based cisst libraries and the Surgical Assistant Workstation framework. It includes a cooperatively controlled EyeRobot2, a da Vinci Master manipulator, and a remote stereo visualization system. We use constrained optimization based virtual fixture control to provide Virtual Remote-Center-of-Motion (vRCM) and haptic feedback. Such system can be used in a hybrid setup, combining local cooperative control with remote tele-operation, where an experienced surgeon can provide hand-over-hand tutoring to a novice user. In another scheme, the system can provide haptic feedback based on virtual fixtures constructed from real-time force and proximity sensor information. PMID:24398557

BgCut: Automatic Ship Detection from UAV Images

PubMed Central

Zhang, Zhengning; Feng, Zhiyong

2014-01-01

Ship detection in static UAV aerial images is a fundamental challenge in sea target detection and precise positioning. In this paper, an improved universal background model based on Grabcut algorithm is proposed to segment foreground objects from sea automatically. First, a sea template library including images in different natural conditions is built to provide an initial template to the model. Then the background trimap is obtained by combing some templates matching with region growing algorithm. The output trimap initializes Grabcut background instead of manual intervention and the process of segmentation without iteration. The effectiveness of our proposed model is demonstrated by extensive experiments on a certain area of real UAV aerial images by an airborne Canon 5D Mark. The proposed algorithm is not only adaptive but also with good segmentation. Furthermore, the model in this paper can be well applied in the automated processing of industrial images for related researches. PMID:24977182

The community distribution of bacteria and fungi on ancient wall paintings of the Mogao Grottoes

PubMed Central

Ma, Yantian; Zhang, He; Du, Ye; Tian, Tian; Xiang, Ting; Liu, Xiande; Wu, Fasi; An, Lizhe; Wang, Wanfu; Gu, Ji-Dong; Feng, Huyuan

2015-01-01

In this study, we compared the microbial communities colonising ancient cave wall paintings of the Mogao Grottoes exhibiting signs of biodeterioration. Ten samples were collected from five different caves built during different time periods and analysed using culture-independent and culture-dependent methods. The clone library results revealed high microbial diversity, including the bacterial groups Firmicutes, Proteobacteria, Actinobacteria, Acidobacteria, Cyanobacteria, Bacteroidetes, Gemmatimonadetes, Planctomycetes, and Chloroflexi and the fungal groups Euascomycetes, Dothideomycetes, Eurotiomycetes, Sordariomycetes, Saccharomycetes, Plectomycetes, Pezizomycetes, Zygomycota, and Basidiomycota. The bacterial community structures differed among the samples, with no consistent temporal or spatial trends. However, the fungal community diversity index correlated with the building time of the caves independent of environmental factors (e.g., temperature or relative humidity). The enrichment cultures revealed that many culturable strains were highly resistant to various stresses and thus may be responsible for the damage to cave paintings in the Mogao Grottoes. PMID:25583346

The community distribution of bacteria and fungi on ancient wall paintings of the Mogao Grottoes.

PubMed

Ma, Yantian; Zhang, He; Du, Ye; Tian, Tian; Xiang, Ting; Liu, Xiande; Wu, Fasi; An, Lizhe; Wang, Wanfu; Gu, Ji-Dong; Feng, Huyuan

2015-01-13

In this study, we compared the microbial communities colonising ancient cave wall paintings of the Mogao Grottoes exhibiting signs of biodeterioration. Ten samples were collected from five different caves built during different time periods and analysed using culture-independent and culture-dependent methods. The clone library results revealed high microbial diversity, including the bacterial groups Firmicutes, Proteobacteria, Actinobacteria, Acidobacteria, Cyanobacteria, Bacteroidetes, Gemmatimonadetes, Planctomycetes, and Chloroflexi and the fungal groups Euascomycetes, Dothideomycetes, Eurotiomycetes, Sordariomycetes, Saccharomycetes, Plectomycetes, Pezizomycetes, Zygomycota, and Basidiomycota. The bacterial community structures differed among the samples, with no consistent temporal or spatial trends. However, the fungal community diversity index correlated with the building time of the caves independent of environmental factors (e.g., temperature or relative humidity). The enrichment cultures revealed that many culturable strains were highly resistant to various stresses and thus may be responsible for the damage to cave paintings in the Mogao Grottoes.

76 FR 4651 - Gresham Municipal Utilities; Notice of Intent To File License Application, Filing of Pre...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... Red Lake Dam Hydroelectric Project. f. Location: On Red River in Shawano County, Wisconsin. No federal... Reference Room or may be viewed on the Commission's Web site ( http://www.ferc.gov ), using the ``eLibrary...

The Governance of Public Libraries: Findings of the PLA Governance of Public Libraries Committee.

ERIC Educational Resources Information Center

Scheppke, Jim

1991-01-01

Describes a survey of library development officers in state library agencies that was conducted to investigate the types of governance structures of public libraries. Highlights include consolidation of public library services, public library boards, trends in public library governance, financial support and managerial effectiveness, and…

QuTiP: An open-source Python framework for the dynamics of open quantum systems

NASA Astrophysics Data System (ADS)

Johansson, J. R.; Nation, P. D.; Nori, Franco

2012-08-01

We present an object-oriented open-source framework for solving the dynamics of open quantum systems written in Python. Arbitrary Hamiltonians, including time-dependent systems, may be built up from operators and states defined by a quantum object class, and then passed on to a choice of master equation or Monte Carlo solvers. We give an overview of the basic structure for the framework before detailing the numerical simulation of open system dynamics. Several examples are given to illustrate the build up to a complete calculation. Finally, we measure the performance of our library against that of current implementations. The framework described here is particularly well suited to the fields of quantum optics, superconducting circuit devices, nanomechanics, and trapped ions, while also being ideal for use in classroom instruction. Catalogue identifier: AEMB_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEMB_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 16 482 No. of bytes in distributed program, including test data, etc.: 213 438 Distribution format: tar.gz Programming language: Python Computer: i386, x86-64 Operating system: Linux, Mac OSX, Windows RAM: 2+ Gigabytes Classification: 7 External routines: NumPy (http://numpy.scipy.org/), SciPy (http://www.scipy.org/), Matplotlib (http://matplotlib.sourceforge.net/) Nature of problem: Dynamics of open quantum systems. Solution method: Numerical solutions to Lindblad master equation or Monte Carlo wave function method. Restrictions: Problems must meet the criteria for using the master equation in Lindblad form. Running time: A few seconds up to several tens of minutes, depending on size of underlying Hilbert space.

Study of Conical Pulsed Inductive Thruster with Multiple Modes of Operation

NASA Technical Reports Server (NTRS)

Miller, Robert; Eskridge, Richard; Martin, Adam; Rose, Frank

2008-01-01

An electrodeless, pulsed, inductively coupled thruster has several advantages over current electric propulsion designs. The efficiency of a pulsed inductive thruster is dependent upon the pulse characteristics of the device. Therefore, these thrusters are throttleable over a wide range of thrust levels by varying the pulse rate without affecting the thruster efficiency. In addition, by controlling the pulse energy and the mass bit together, the ISP of the thruster can also be varied with minimal efficiency loss over a wide range of ISP levels. Pulsed inductive thrusters will work with a multitude of propellants, including ammonia. Thus, a single pulsed inductive thruster could be used to handle a multitude of mission needs from high thrust to high ISP with one propulsion solution that would be variable in flight. A conical pulsed inductive lab thruster has been built to study this form of electric propulsion in detail. This thruster incorporates many advantages that are meant to enable this technology as a viable space propulsion technology. These advantages include incorporation of solid state switch technology for all switching needs of the thruster and pre-ionization of the propellant gas prior to acceleration. Pre-ionizing will significantly improve coupling efficiency between drive and bias fields and the plasma. This enables lower pulse energy levels without efficiency reduction. Pre-ionization can be accomplished at a small fraction of the drive pulse energy.

CD-ROM as a Library Equivalent.

ERIC Educational Resources Information Center

Reid, Harold T.

1992-01-01

Provides a brief overview of CD-ROM products that emulate a library's print collection. Highlights include reference works, including "Microsoft Bookshelf" and "Toolworks Reference Library"; the "New Grolier Electronic Encyclopedia"; periodicals and news services, including "Magazine Rack" and "Front…

Focus groups for allied health professionals and professions allied to technical services in the NHS--marketing opportunities, lessons learnt and recommendations.

PubMed

Chamberlain, David; Brook, Richard

2011-09-01

Worcestershire Health Libraries provides services to all NHS and social care staff in Worcestershire. Despite intensive marketing, statistics showed low usage of the library service for professions allied to technical services and allied health professionals. To discover why there was low usage of the library services using qualitative techniques and to use focus groups as a marketing opportunity. This article also aims to outline the processes involved in delivering focus groups, the results gained, and the actions taken in response to the results. Focus groups were conducted in two departments, Pathology and Occupational Therapy. The Biochemistry department (part of Pathology) had two focus groups. An additional focus group was conducted for all the Pathology education leads. Occupational Therapy had two meetings, one for hospital based staff, and the other for community staff. Issues centred on registration, inductions, time, library ambience, multi-disciplinary service and resources. The findings raised marketing opportunities and the process identified potential candidates for the role of team knowledge officer, to act as library champions within departments. It also identified areas in which the library service was not meeting user needs and expectations, and helped focus service development. Focus groups allowed an opportunity to speak to non-users face to face and to discover, and where appropriate challenge both their, and library staff's pre-conceived ideas about the service. The information revealed gave an opportunity to market services based on user needs. © 2011 The authors. Health Information and Libraries Journal © 2011 Health Libraries Group.

Digitally available interval-specific rock-sample data compiled from historical records, Nevada National Security Site and vicinity, Nye County, Nevada

USGS Publications Warehouse

Wood, David B.

2007-11-01

Between 1951 and 1992, 828 underground tests were conducted on the Nevada National Security Site, Nye County, Nevada. Prior to and following these nuclear tests, holes were drilled and mined to collect rock samples. These samples are organized and stored by depth of borehole or drift at the U.S. Geological Survey Core Library and Data Center at Mercury, Nevada, on the Nevada National Security Site. From these rock samples, rock properties were analyzed and interpreted and compiled into project files and in published reports that are maintained at the Core Library and at the U.S. Geological Survey office in Henderson, Nevada. These rock-sample data include lithologic descriptions, physical and mechanical properties, and fracture characteristics. Hydraulic properties also were compiled from holes completed in the water table. Rock samples are irreplaceable because pre-test, in-place conditions cannot be recreated and samples can not be recollected from the many holes destroyed by testing. Documenting these data in a published report will ensure availability for future investigators.

Emergency medical services and congestion : urban sprawl and pre-hospital emergency care time.

DOT National Transportation Integrated Search

2009-01-01

This research measured the association between urban sprawl and emergency medical service (EMS) response time. The purpose was to test the hypothesis that features of the built environment increase the probability of delayed ambulance arrival. Using ...

Accelerated load testing of geosynthetic base reinforced pavement test sections.

DOT National Transportation Integrated Search

2011-02-01

The main objective of this research is to evaluate the benefits of geosynthetic stabilization and reinforcement of subgrade/base aggregate layers in flexible pavements built on weak subgrades and the effect of pre-rut pavement sections, prior to the ...

Pre-eclampsia Diagnosis and Treatment Options: A Review of Published Economic Assessments.

PubMed

Zakiyah, Neily; Postma, Maarten J; Baker, Philip N; van Asselt, Antoinette D I

2015-10-01

Pre-eclampsia is a pregnancy complication affecting both mother and fetus. Although there is no proven effective method to prevent pre-eclampsia, early identification of women at risk of pre-eclampsia could enhance appropriate application of antenatal care, management and treatment. Very little is known about the cost effectiveness of these and other tests for pre-eclampsia, mainly because there is no clear treatment path. The aim of this study was to provide a comprehensive overview of the existing evidence on the health economics of screening, diagnosis and treatment options in pre-eclampsia. We searched three electronic databases (PubMed, EMBASE and the Cochrane Library) for studies on screening, diagnosis, treatment or prevention of pre-eclampsia, published between 1994 and 2014. Only full papers written in English containing complete economic assessments in pre-eclampsia were included. From an initial total of 138 references, six papers fulfilled the inclusion criteria. Three studies were on the cost effectiveness of treatment of pre-eclampsia, two of which evaluated magnesium sulphate for prevention of seizures and the third evaluated the cost effectiveness of induction of labour versus expectant monitoring. The other three studies were aimed at screening and diagnosis, in combination with subsequent preventive measures. The two studies on magnesium sulphate were equivocal on the cost effectiveness in non-severe cases, and the other study suggested that induction of labour in term pre-eclampsia was more cost effective than expectant monitoring. The screening studies were quite diverse in their objectives as well as in their conclusions. One study concluded that screening is probably not worthwhile, while two other studies stated that in certain scenarios it may be cost effective to screen all pregnant women and prophylactically treat those who are found to be at high risk of developing pre-eclampsia. This study is the first to provide a comprehensive overview on the economic aspects of pre-eclampsia in its broadest sense, ranging from screening to treatment options. The main limitation of the present study lies in the variety of topics in combination with the limited number of papers that could be included; this restricted the comparisons that could be made. In conclusion, novel biomarkers in screening for and diagnosing pre-eclampsia show promise, but their accuracy is a major driver of cost effectiveness, as is prevalence. Universal screening for pre-eclampsia, using a biomarker, will be feasible only when accuracy is significantly increased.

America's Star Libraries, 2010: Top-Rated Libraries

ERIC Educational Resources Information Center

Lyons, Ray; Lance, Keith Curry

2010-01-01

The "LJ" Index of Public Library Service 2010, "Library Journal"'s national rating of public libraries, identifies 258 "star" libraries. Created by Ray Lyons and Keith Curry Lance, and based on 2008 data from the IMLS, it rates 7,407 public libraries. The top libraries in each group get five, four, or three stars. All included libraries, stars or…

America's Star Libraries: Top-Rated Libraries

ERIC Educational Resources Information Center

Lance, Keith Curry; Lyons, Ray

2009-01-01

"Library Journal"'s national rating of public libraries, the "LJ" Index of Public Library Service 2009, Round 2, identifies 258 "star" libraries. Created by Keith Curry Lance and Ray Lyons and based on 2007 data from the IMLS, it rates 7,268 public libraries. The top libraries in each group get five, four, or three stars. All included libraries,…

An Observation Analysis Tool for time-series analysis and sensor management in the FREEWAT GIS environment for water resources management

NASA Astrophysics Data System (ADS)

Cannata, Massimiliano; Neumann, Jakob; Cardoso, Mirko; Rossetto, Rudy; Foglia, Laura; Borsi, Iacopo

2017-04-01

In situ time-series are an important aspect of environmental modelling, especially with the advancement of numerical simulation techniques and increased model complexity. In order to make use of the increasing data available through the requirements of the EU Water Framework Directive, the FREEWAT GIS environment incorporates the newly developed Observation Analysis Tool for time-series analysis. The tool is used to import time-series data into QGIS from local CSV files, online sensors using the istSOS service, or MODFLOW model result files and enables visualisation, pre-processing of data for model development, and post-processing of model results. OAT can be used as a pre-processor for calibration observations, integrating the creation of observations for calibration directly from sensor time-series. The tool consists in an expandable Python library of processing methods and an interface integrated in the QGIS FREEWAT plug-in which includes a large number of modelling capabilities, data management tools and calibration capacity.

Spectra of late type dwarf stars of known abundance for stellar population models

NASA Technical Reports Server (NTRS)

Oconnell, R. W.

1990-01-01

The project consisted of two parts. The first was to obtain new low-dispersion, long-wavelength, high S/N IUE spectra of F-G-K dwarf stars with previously determined abundances, temperatures, and gravities. To insure high quality, the spectra are either trailed, or multiple exposures are taken within the large aperture. Second, the spectra are assembled into a library which combines the new data with existing IUE Archive data to yield mean spectral energy distributions for each important type of star. My principal responsibility is the construction and maintenance of this UV spectral library. It covers the spectral range 1200-3200A and is maintained in two parts: a version including complete wavelength coverage at the full spectral resolution of the Low Resolution cameras; and a selected bandpass version, consisting of the mean flux in pre-selected 20A bands. These bands are centered on spectral features or continuum regions of special utility - e.g. the C IV lambda 1550 or Mg II lambda 2800 feature. In the middle-UV region, special emphasis is given to those features (including continuum 'breaks') which are most useful in the study of F-G-K star spectra in the integrated light of old stellar populations.

IYA2009 NASA Programs: Midyear Status

NASA Astrophysics Data System (ADS)

Hasan, H.; Smith, D. A.

2010-08-01

NASA's Science Mission Directorate's (SMD) celebration of the International Year of Astronomy (IYA) 2009 was kicked off in January 2009 with a sneak preview of a multi-wavelength image of M101, and of other images from NASA's space science missions. Since then some of the exciting science generated by NASA's missions in astrophysics, planetary science and heliophysics, which has been given an IYA2009 flavor, has been made available to students, educators and the public worldwide. Some examples of the progress of NASA's programs are presented. The Visions of the Universe traveling exhibit of NASA images to public libraries around the country has been a spectacular success and is being extended to include more libraries. NASA IYA Student Ambassadors met at summer workshop and presented their projects. NASA's Afterschool Universe has provided IYA training to community-based organizations, while pre-launch teacher workshops associated with the Kepler and WISE missions have been designed to engage educators in the science of these missions. IYA activities have been associated with several missions launched this year. These include the Hubble Servicing Mission 4, Kepler, Herschel/Planck, and LCROSS. The NASA IYA website continues to be popular, getting visitors spanning a wide spectrum. NASA's IYA programs have captured the imagination of the public and continue to keep it engaged in the scientific exploration of the universe.

RIMS: An Integrated Mapping and Analysis System with Applications to Earth Sciences and Hydrology

NASA Astrophysics Data System (ADS)

Proussevitch, A. A.; Glidden, S.; Shiklomanov, A. I.; Lammers, R. B.

2011-12-01

A web-based information and computational system for analysis of spatially distributed Earth system, climate, and hydrologic data have been developed. The System allows visualization, data exploration, querying, manipulation and arbitrary calculations with any loaded gridded or vector polygon dataset. The system's acronym, RIMS, stands for its core functionality as a Rapid Integrated Mapping System. The system can be deployed for a Global scale projects as well as for regional hydrology and climatology studies. In particular, the Water Systems Analysis Group of the University of New Hampshire developed the global and regional (Northern Eurasia, pan-Arctic) versions of the system with different map projections and specific data. The system has demonstrated its potential for applications in other fields of Earth sciences and education. The key Web server/client components of the framework include (a) a visualization engine built on Open Source libraries (GDAL, PROJ.4, etc.) that are utilized in a MapServer; (b) multi-level data querying tools built on XML server-client communication protocols that allow downloading map data on-the-fly to a client web browser; and (c) data manipulation and grid cell level calculation tools that mimic desktop GIS software functionality via a web interface. Server side data management of the system is designed around a simple database of dataset metadata facilitating mounting of new data to the system and maintaining existing data in an easy manner. RIMS contains "built-in" river network data that allows for query of upstream areas on-demand which can be used for spatial data aggregation and analysis of sub-basin areas. RIMS is an ongoing effort and currently being used to serve a number of websites hosting a suite of hydrologic, environmental and other GIS data.

Tight control of mild-moderate pre-existing or non-proteinuric gestational hypertension.

PubMed

Nabhan, Ashraf F; Elsedawy, Maged M

2011-07-06

The question of the target blood pressure in pregnant women with mild-moderate hypertension continues to be an area of debate. To compare tight versus very tight control of mild-moderate pre-existing or non-proteinuric gestational hypertension for improving outcomes We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2011), CENTRAL (The Cochrane Library 2011, Issue 3), MEDLINE (January 1966 to March 2011), and the metaRegister of Controlled Trials (31 March 2011). We handsearched citation lists of relevant publications, review articles, and included studies. Randomized controlled trials of tight versus very tight control in pregnant women with mild or moderate pre-existing or non-proteinuric gestational hypertension. Two authors independently assessed trial quality and extracted data. We expressed results as risk ratio (RR) or mean differences, together with their 95% confidence intervals (CI). We included two studies (256 participants) with mild-moderate pre-existing or non-proteinuric gestational hypertension. There was no evidence of a difference between tight and very tight control groups regarding severe pre-eclampsia (risk ratio (RR) 1.28, 95% CI 0.97 to 1.70; two trials, 256 participants). More women in the tight group were hospitalized during their pregnancy (RR 2.53, 95% CI 1.14 to 5.63; one trial, 125 participants). There was no evidence of a difference in other outcome measures including fetal distress, IUGR, neonatal admission to a NICU, perinatal deaths, induction of labor and cesarean delivery between the tight and the very tight control groups. Gestational age at delivery had a non-significant mean difference (MD) of -0.15 weeks between the tight and very tight control groups (MD -0.15, 95% CI -1.52 to 1.21, random-effects, T² = 0.75, I² = 77%; two trials, 256 participants). The MD in birthweight between the tight and the very tight control group was not significant (MD -100.00 grams, 95% CI -363.69 to 163.69; one trial, 125 participants). For pregnant women with non-severe pre-existing or non-proteinuric gestational hypertension, there is insufficient evidence to determine how tight control of hypertension should be achieved to improve maternal and fetal-neonatal outcomes.

The Next Stage: Moving from Isolated Digital Collections to Interoperable Digital Libraries.

ERIC Educational Resources Information Center

Besser, Howard

2002-01-01

Presents a conceptual framework for digital library development and discusses how to move from isolated digital collections to interoperable digital libraries. Topics include a history of digital libraries; user-centered architecture; stages of technological development; standards, including metadata; and best practices. (Author/LRW)

Building Earth's Largest Library: Driving into the Future.

ERIC Educational Resources Information Center

Coffman, Steve

1999-01-01

Examines the Amazon.com online bookstore as a blueprint for designing the world's largest library. Topics include selection; accessibility and convenience; quality of Web sites and search tools; personalized service; library collection development, including interlibrary loan; library catalogs and catalog records; a circulation system; costs;…

42 CFR 4.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS NATIONAL LIBRARY OF MEDICINE..., videotapes, recordings, manuscripts, and other resource materials of the library. It does not include data..., nor does it include “records” of the Library as defined in 45 CFR 5.5. Records of the Library are...

Temple University Libraries in the Mid-Seventies: A Status Report.

ERIC Educational Resources Information Center

Nitecki, Joseph Z.

Present central library operations are discussed in terms of emerging needs and possible direction for future development. Library objectives include acquiring and organizing relevant records of knowledge, and providing satisfactory information service standards. Issues relating to objectives include the library's involvement in planning and…

42 CFR 4.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS NATIONAL LIBRARY OF MEDICINE..., videotapes, recordings, manuscripts, and other resource materials of the library. It does not include data..., nor does it include “records” of the Library as defined in 45 CFR 5.5. Records of the Library are...

42 CFR 4.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS NATIONAL LIBRARY OF MEDICINE..., videotapes, recordings, manuscripts, and other resource materials of the library. It does not include data..., nor does it include “records” of the Library as defined in 45 CFR 5.5. Records of the Library are...

42 CFR 4.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS NATIONAL LIBRARY OF MEDICINE..., videotapes, recordings, manuscripts, and other resource materials of the library. It does not include data..., nor does it include “records” of the Library as defined in 45 CFR 5.5. Records of the Library are...

User's guide for mapIMG 3--Map image re-projection software package

USGS Publications Warehouse

Finn, Michael P.; Mattli, David M.

2012-01-01

Version 0.0 (1995), Dan Steinwand, U.S. Geological Survey (USGS)/Earth Resources Observation Systems (EROS) Data Center (EDC)--Version 0.0 was a command line version for UNIX that required four arguments: the input metadata, the output metadata, the input data file, and the output destination path. Version 1.0 (2003), Stephen Posch and Michael P. Finn, USGS/Mid-Continent Mapping Center (MCMC--Version 1.0 added a GUI interface that was built using the Qt library for cross platform development. Version 1.01 (2004), Jason Trent and Michael P. Finn, USGS/MCMC--Version 1.01 suggested bounds for the parameters of each projection. Support was added for larger input files, storage of the last used input and output folders, and for TIFF/ GeoTIFF input images. Version 2.0 (2005), Robert Buehler, Jason Trent, and Michael P. Finn, USGS/National Geospatial Technical Operations Center (NGTOC)--Version 2.0 added Resampling Methods (Mean, Mode, Min, Max, and Sum), updated the GUI design, and added the viewer/pre-viewer. The metadata style was changed to XML and was switched to a new naming convention. Version 3.0 (2009), David Mattli and Michael P. Finn, USGS/Center of Excellence for Geospatial Information Science (CEGIS)--Version 3.0 brings optimized resampling methods, an updated GUI, support for less than global datasets, UTM support and the whole codebase was ported to Qt4.

Re-inventing Data Libraries: Ensuring Continuing Access To Curated (Value-added) Data

NASA Astrophysics Data System (ADS)

Burnhill, P.; Medyckyj-Scott, D.

2008-12-01

How many years of inexperience do we need in using, and in particular sharing, digital data generated by others? That history pre-dates, but must also gain leverage from, the emergence of the digital library. Much of this sharing was done within research groups but recent attention to spatial data infrastructure highlights the importance of achieving several 'right mixes': * between Internet-standards, geo-specific referencing, and domain-specific vocabulary (cf ontology); * between attention to user-focus'd services and machine-to-machine interoperability; * between the demands of current high-quality services, the practice of data curation, and the need for long term preservation. This presentation will draw upon ideas and experience data library services in research universities, a national (UK) academic data centre, and developments in digital curation. It will be argued that the 1980s term 'data library' has some polemic value in that we have yet to learn what it means to 'do library' for data: more than "a bit like inter-galactic library loan", perhaps. Illustration will be drawn from multi-faceted database of digitized boundaries (UKBORDERS), through the first Internet map delivery of national mapping agency data (Digimap), to strategic positioning to help geo-enable academic and scientific data and so enhance research (in the UK, in Europe, and beyond).

Library Law Handbook: State Laws Relating to Michigan Libraries. 1993 Edition.

ERIC Educational Resources Information Center

Michigan Library, Lansing.

This document is a compilation of state laws relating to Michigan libraries, intended as a tool for library managers and as an expression of continued commitment to strengthening library services throughout the state. It reprints legislation directly related to libraries of all levels, including: library networks; regional libraries: district…

America's Star Libraries

ERIC Educational Resources Information Center

Lyons, Ray; Lance, Keith Curry

2009-01-01

"Library Journal"'s new national rating of public libraries, the "LJ" Index of Public Library Service, identifies 256 "star" libraries. It rates 7,115 public libraries. The top libraries in each group get five, four, or three Michelin guide-like stars. All included libraries, stars or not, can use their scores to learn from their peers and improve…

Interior effects on comfort in healthcare waiting areas.

PubMed

Bazley, C; Vink, P; Montgomery, J; Hedge, A

2016-07-21

This study compared the effects of pre-experience and expectations on participant comfort upon waking, arrival to, and after an appointment, as well as the assessment of properly placed Feng Shui elements in three healthcare waiting rooms. Participants assessed comfort levels using self-report surveys. The researcher conducted 'intention interviews' with each doctor to assess the goals of each waiting area design, and conducted a Feng Shui assessment of each waiting area for properly placed Feng Shui elements. The waiting area designed by the Feng Shui expert rated 'most comfortable', followed by the waiting area design by a doctor, and the lowest comfort rating for the conventional waiting room design. Results show a sufficiently strong effect to warrant further research. Awareness of the external environment, paired with pre-experience and expectation, influences comfort for people over time. Fostering and encouraging a holistic approach to comfort utilizing eastern and western concepts and ergonomic principles creates a sense of "placeness" and balance in the design for comfort in built environments. This is new research information on the influences of the comfort experience over time, to include pre-experience, expectations and the placement of elements in the external environment.

RESOURCES OF CANADIAN ACADEMIC AND RESEARCH LIBRARIES.

ERIC Educational Resources Information Center

DOWNS, ROBERT B.

ALTHOUGH IT EMPHASIZES ACADEMIC LIBRARIES, THIS STUDY ALSO INCLUDES THE NATIONAL AND PROVINCIAL LIBRARIES, LARGE PUBLIC LIBRARIES, AND SPECIAL LIBRARIES THAT SERVE CANADIAN SCHOLARS, STUDENTS, AND RESEARCH WORKERS. WITH THE DATA OBTAINED FROM A QUESTIONNAIRE ON LIBRARY STATISTICS AND HOLDINGS, VISITS TO THE LIBRARIES, INTERVIEWS WITH LIBRARIANS…

Computer-Aided Design for Built-In-Test (CADBIT) - BIT Library. Volume 2

DTIC Science & Technology

1989-10-01

TECHNIQUE: ON-BOARD RONI CATEGORY: LONG TUTORIA \\L PAG E 5 of 14I SUBCATEGORY: BIT TECHNIQUE ATTRIBUTES DATA TYPE: TEXT El LIST E] TABLE [ GRAPHIC E...SHIFT REGISTER (MISR) CATEGORY: LONG TUTORIA -L PAGE i Of 13 SUBCATEGORY: BIT TECH-{MQUE ATTRIBUTES DATA TYPE: TEXT LIST El TABLE GRAPHIC E EQUATIONS...ELEMENT DATA SHEET BIT TECHNIQUE: UTILIZING REDUNDANCY CATEGORY: LONG TUTORIA L PAGE 9 of 10 SUBCATEGORY: PARTS DATA TABLE DATA TYPE: TEXT F1 UST C3

Fully-Implicit Navier-Stokes (FIN-S)

NASA Technical Reports Server (NTRS)

Kirk, Benjamin S.

2010-01-01

FIN-S is a SUPG finite element code for flow problems under active development at NASA Lyndon B. Johnson Space Center and within PECOS: a) The code is built on top of the libMesh parallel, adaptive finite element library. b) The initial implementation of the code targeted supersonic/hypersonic laminar calorically perfect gas flows & conjugate heat transfer. c) Initial extension to thermochemical nonequilibrium about 9 months ago. d) The technologies in FIN-S have been enhanced through a strongly collaborative research effort with Sandia National Labs.

SNLSimMagic v 2.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

This software is an iOS (Apple) Augmented Reality (AR) application that runs on the iPhone and iPad. It is designed to scan in a photograph or graphic and "play" an associated video. This release, SNLSimMagic, was built using Wikitude Augmented Reality (AR) software development kit (SDK) integrated into Apple iOS SDK application and the Cordova libraries. These codes enable the generation of runtime targets using cloud recognition and developer-defined target features which are then accessed by means of a custom application.

An Embedded Librarian Program: Eight Years On.

PubMed

Freiburger, Gary; Martin, Jennifer R; Nuñez, Annabelle V

2016-01-01

This article examines an embedded librarian program eight years after implementation in a large academic health center. Librarians were physically moved into the colleges of pharmacy, public health, and nursing. Statistics are reported as well as comments from the participating librarians and faculty members. Strong relationships have been built between librarians, faculty members, and students. Locating the librarians among faculty and students led to a better understanding of client needs and an increased awareness of librarian competencies and services resulting in partnerships and greater utilization of library services.

IFLA General Conference, 1984. General Research Libraries Division. Section on Parliamentary Libraries; Section on Public Libraries; Section on University and Other General Research Libraries. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on government libraries, public libraries, and research libraries presented at the 1984 IFLA general conference include: (1) "Library Services for Research" (Maria S. Pla de Menendez, Colombia); (2) "Interlibrary Loans, Present and Future: A Consideration for Academic Library Management" (Geoffrey G. Allen, Australia);…

California Dreaming.

ERIC Educational Resources Information Center

Quinn, Judy

1992-01-01

Describes the design plans for San Francisco Public Library's new Main Library. Highlights include administrative issues, including the role of branch libraries; funding; technology, both for the building itself and for the collections; accessibility for the physically impaired; special collections; and future plans, including an integrated…

Vertical Directionality of Low Frequency Ambient Noise in the South Fiji Basin.

DTIC Science & Technology

1982-01-21

6611 MAW- 10 414 -F- SIM04 To get a perspective on the size of the Autobuoy, it is shown here in a pre- deployment mode over the stern of an AGOR ship...The only practical limitation regarding noise measurements is a reluctance to deploy and retrieve in high sea I . , i, i j i, H i iii i • S TD6611 DAY...Diachok) 7 NOSC, San Diego (J. R. Lovett; J. L. Stewart (Code 724); Library) 3 NPS, Monterey (Prof. C. N. Mooers, Prof. H . Medwin, Library) 3 NORDA, NSTL

Tobacco Industry Promotional Strategies Targeting American Indians/Alaska Natives and Exploiting Tribal Sovereignty.

PubMed

Lempert, Lauren K; Glantz, Stanton A

2018-03-12

American Indians/Alaska Natives have the highest commercial tobacco use in the United States, resulting in higher tobacco-caused deaths and diseases than the general population. Some American Indians/Alaska Natives use commercial tobacco for ceremonial as well as recreational uses. Because federally-recognized Tribal lands are sovereign, they are not subject to state cigarette taxes and smokefree laws. This study analyzes tobacco industry promotional efforts specifically targeting American Indians/Alaska Natives and exploiting Tribal lands to understand appropriate policy responses in light of American Indians'/Alaska Natives' unique sovereign status and culture. We analyzed previously secret tobacco industry documents available at the Truth Tobacco Documents Library (https://industrydocuments.library.ucsf.edu/tobacco/). Tobacco companies used promotional strategies targeting American Indians/Alaska Natives and exploiting Tribal lands that leveraged the federally-recognized Tribes' unique sovereign status exempting them from state cigarette taxes and smokefree laws, and exploited some Tribes' existing traditional uses of ceremonial tobacco and poverty. Tactics included price reductions, coupons, giveaways, gaming promotions, charitable contributions and sponsorships. Additionally, tobacco companies built alliances with Tribal leaders to help improve their corporate image, advance ineffective "youth smoking prevention" programs, and defeat tobacco control policies. The industry's promotional tactics likely contribute to disparities in smoking prevalence and smoking-related diseases among American Indians//Alaska Natives. Proven policy interventions to address these disparities including tobacco price increases, cigarette taxes, comprehensive smokefree laws, and industry denormalization campaigns to reduce smoking prevalence and smoking-related disease could be considered by Tribal communities. The sovereign status of federally-recognized Tribes does not prevent them from adopting these measures.

Directed Chemical Evolution with an Outsized Genetic Code

PubMed Central

Krusemark, Casey J.; Tilmans, Nicolas P.; Brown, Patrick O.; Harbury, Pehr B.

2016-01-01

The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a powerful tool that now dominates all aspects of protein engineering. A challenge has been to extend this scientific advance into synthetic chemical space: to enable the directed evolution of abiotic molecules. The problem has been tackled in many ways. These include expanding the natural genetic code to include unnatural amino acids, engineering polyketide and polypeptide synthases to produce novel products, and tagging combinatorial chemistry libraries with DNA. Importantly, there is still no small-molecule analog of directed protein evolution, i.e. a substantiated approach for optimizing complex (≥ 10^9 diversity) populations of synthetic small molecules over successive generations. We present a key advance towards this goal: a tool for genetically-programmed synthesis of small-molecule libraries from large chemical alphabets. The approach accommodates alphabets that are one to two orders of magnitude larger than any in Nature, and facilitates evolution within the chemical spaces they create. This is critical for small molecules, which are built up from numerous and highly varied chemical fragments. We report a proof-of-concept chemical evolution experiment utilizing an outsized genetic code, and demonstrate that fitness traits can be passed from an initial small-molecule population through to the great-grandchildren of that population. The results establish the practical feasibility of engineering synthetic small molecules through accelerated evolution. PMID:27508294

MsSpec-1.0: A multiple scattering package for electron spectroscopies in material science

NASA Astrophysics Data System (ADS)

Sébilleau, Didier; Natoli, Calogero; Gavaza, George M.; Zhao, Haifeng; Da Pieve, Fabiana; Hatada, Keisuke

2011-12-01

We present a multiple scattering package to calculate the cross-section of various spectroscopies namely photoelectron diffraction (PED), Auger electron diffraction (AED), X-ray absorption (XAS), low-energy electron diffraction (LEED) and Auger photoelectron coincidence spectroscopy (APECS). This package is composed of three main codes, computing respectively the cluster, the potential and the cross-section. In the latter case, in order to cover a range of energies as wide as possible, three different algorithms are provided to perform the multiple scattering calculation: full matrix inversion, series expansion or correlation expansion of the multiple scattering matrix. Numerous other small Fortran codes or bash/csh shell scripts are also provided to perform specific tasks. The cross-section code is built by the user from a library of subroutines using a makefile. Program summaryProgram title: MsSpec-1.0 Catalogue identifier: AEJT_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEJT_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 504 438 No. of bytes in distributed program, including test data, etc.: 14 448 180 Distribution format: tar.gz Programming language: Fortran 77 Computer: Any Operating system: Linux, MacOs RAM: Bytes Classification: 7.2 External routines: Lapack ( http://www.netlib.org/lapack/) Nature of problem: Calculation of the cross-section of various spectroscopies. Solution method: Multiple scattering. Running time: The test runs provided only take a few seconds to run.

Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides.

PubMed

Duffy, Fergal J; O'Donovan, Darragh; Devocelle, Marc; Moran, Niamh; O'Connell, David J; Shields, Denis C

2015-03-23

Protein-protein and protein-peptide interactions are responsible for the vast majority of biological functions in vivo, but targeting these interactions with small molecules has historically been difficult. What is required are efficient combined computational and experimental screening methods to choose among a number of potential protein interfaces worthy of targeting lead macrocyclic compounds for further investigation. To achieve this, we have generated combinatorial 3D virtual libraries of short disulfide-bonded peptides and compared them to pharmacophore models of important protein-protein and protein-peptide structures, including short linear motifs (SLiMs), protein-binding peptides, and turn structures at protein-protein interfaces, built from 3D models available in the Protein Data Bank. We prepared a total of 372 reference pharmacophores, which were matched against 108,659 multiconformer cyclic peptides. After normalization to exclude nonspecific cyclic peptides, the top hits notably are enriched for mimetics of turn structures, including a turn at the interaction surface of human α thrombin, and also feature several protein-binding peptides. The top cyclic peptide hits also cover the critical "hot spot" interaction sites predicted from the interaction crystal structure. We have validated our method by testing cyclic peptides predicted to inhibit thrombin, a key protein in the blood coagulation pathway of important therapeutic interest, identifying a cyclic peptide inhibitor with lead-like activity. We conclude that protein interfaces most readily targetable by cyclic peptides and related macrocyclic drugs may be identified computationally among a set of candidate interfaces, accelerating the choice of interfaces against which lead compounds may be screened.