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Sample records for including brofaromine harmine

  1. Brofaromine: a monoamine oxidase-A and serotonin uptake inhibitor.

    PubMed

    Waldmeier, P C; Glatt, A; Jaekel, J; Bittiger, H

    1993-01-01

    Brofaromine is a tight-binding, reversible inhibitor of monoamine oxidase-A (MAO-A), with concomitant serotonin (5-HT) uptake-inhibiting properties. In psychopharmacologic investigations, the compound shows the properties expected of an MAO inhibitor, antagonizing the effects of reserpine, tetrabenazine, and 5-hydroxytryptophan in rats and mice, and suppressing rapid eye movement sleep in cats. Brofaromine showed antidepressant-like activity in a rat social conflict test. In radioligand binding assays, brofaromine exhibited weak or no interaction with alpha 1- and alpha 2-noradrenergic, 5-HT1, 5-HT2, 5-HT3, cholinergic, histamine H1 and H2, mu-opiate, GABAA, benzodiazepine, adenosine, neurotensin, and substance P receptors. Comparison of in vitro and in vivo potencies to inhibit 5-HT uptake with those of reference drugs, and direct evidence in patients and volunteers suggest that 5-HT uptake inhibition plays a role in the clinical profile of brofaromine.

  2. Harmine stimulates proliferation of human neural progenitors

    PubMed Central

    Dakic, Vanja; Maciel, Renata de Moraes; Drummond, Hannah; Nascimento, Juliana M.; Trindade, Pablo

    2016-01-01

    Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive) derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A), which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY), and an irreversible selective inhibitor of monoamine oxidase (MAO) but not DYRK1A (pargyline). INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo. PMID:27957390

  3. Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling

    SciTech Connect

    Yonezawa, Takayuki; Lee, Ji-Won; Hibino, Ayaka; Asai, Midori; Hojo, Hironori; Cha, Byung-Yoon; Teruya, Toshiaki; Nagai, Kazuo; Chung, Ung-Il; Yagasaki, Kazumi; and others

    2011-06-03

    Highlights: {yields} Harmine promotes the activity and mRNA expression of ALP. {yields} Harmine enhances the expressions of osteocalcin mRNA and protein. {yields} Harmine induces osteoblastic mineralization. {yields} Harmine upregulates the mRNA expressions of BMPs, Runx2 and Osterix. {yields} BMP signaling pathways are involved in the actions of harmine. -- Abstract: Bone mass is regulated by osteoblast-mediated bone formation and osteoclast-mediated bone resorption. We previously reported that harmine, a {beta}-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo. In this study, we investigated the effects of harmine on osteoblast proliferation, differentiation and mineralization. Harmine promoted alkaline phosphatase (ALP) activity in MC3T3-E1 cells without affecting their proliferation. Harmine also increased the mRNA expressions of the osteoblast marker genes ALP and Osteocalcin. Furthermore, the mineralization of MC3T3-E1 cells was enhanced by treatment with harmine. Harmine also induced osteoblast differentiation in primary calvarial osteoblasts and mesenchymal stem cell line C3H10T1/2 cells. Structure-activity relationship studies using harmine-related {beta}-carboline alkaloids revealed that the C3-C4 double bond and 7-hydroxy or 7-methoxy group of harmine were important for its osteogenic activity. The bone morphogenetic protein (BMP) antagonist noggin and its receptor kinase inhibitors dorsomorphin and LDN-193189 attenuated harmine-promoted ALP activity. In addition, harmine increased the mRNA expressions of Bmp-2, Bmp-4, Bmp-6, Bmp-7 and its target gene Id1. Harmine also enhanced the mRNA expressions of Runx2 and Osterix, which are key transcription factors in osteoblast differentiation. Furthermore, BMP-responsive and Runx2-responsive reporters were activated by harmine treatment. Taken together, these results indicate that harmine enhances osteoblast differentiation probably by inducing the expressions of

  4. Developments in harmine pharmacology--implications for ayahuasca use and drug-dependence treatment.

    PubMed

    Brierley, Daniel I; Davidson, Colin

    2012-12-03

    Ayahuasca is a hallucinogenic botanical mixture originating in the Amazon area where it is used ritually, but is now being taken globally. The 2 main constituents of ayahuasca are N,N-dimethyltryptamine (DMT), a hallucinogen, and harmine, a monoamine oxidase inhibitor (MAOI) which attenuates the breakdown of DMT, which would otherwise be broken down very quickly after oral consumption. Recent developments in ayahuasca use include the sale of these compounds on the internet and the substitution of related botanical (anahuasca) or synthetic (pharmahuasca) compounds to achieve the same desired hallucinogenic effects. One intriguing result of ayahuasca use appears to be improved mental health and a reduction in recidivism to alternate (alcohol, cocaine) drug use. In this review we discuss the pharmacology of ayahuasca, with a focus on harmine, and suggest pharmacological mechanisms for the putative reduction in recidivism to alcohol and cocaine misuse. These pharmacological mechanisms include MAOI, effects at 5-HT(2A) and imidazoline receptors and inhibition of dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) and the dopamine transporter. We also speculate on the therapeutic potential of harmine in other CNS conditions.

  5. Harmine, A Natural Beta-Carboline Alkaloid, Upregulates Astroglial Glutamate Transporter Expression

    PubMed Central

    Li, Yun; Sattler, Rita; Yang, Eun Ju; Nunes, Alice; Ayukawa, Yoko; Akhtar, Sadia; Ji, Grace; Zhang, Ping-Wu; Rothstein, Jeffrey D.

    2011-01-01

    Glutamate is the predominant excitatory amino acid neurotransmitter in the mammalian central nervous system (CNS). Glutamate transporter EAAT2 /GLT-1 is the physiologically dominant astroglial protein that inactivates synaptic glutamate. Previous studies have shown that EAAT2 dysfunction leads to excessive extracellular glutamate and may contribute to various neurological disorders including amyotrophic lateral sclerosis (ALS). The recent discovery of the neuroprotective properties of ceftriaxone, a beta lactam antibiotic, suggested that increasing EAAT2 /GLT-1 gene expression might be beneficial in ALS and other neurological/psychiatric disorders by augmenting astrocytic glutamate uptake. Here we report our efforts to develop a new screening assay for identifying compounds that activate EAAT2 gene expression. We generated fetal derived-human immortalized astroglial cells that are stably expressing a firefly luciferase reporter under the control of the human EAAT2 promoter. When screening a library of 1040 FDA approved compounds and natural products, we identified harmine, a naturally occurring beta-carboline alkaloid, as one of the top hits for activating the EAAT2 promoter. We further tested harmine in our in vitro cell culture systems and confirmed its ability to increase EAAT2/GLT1 gene expression and functional glutamate uptake activity. We next tested its efficacy in both wild type animals and in an ALS animal model of disease and demonstrated that harmine effectively increased GLT-1 protein and glutamate transporter activity in vivo. Our studies provide potential novel neurotherapeutics by modulating the activity of glutamate transporters via gene activation. PMID:21034752

  6. Pharmacological evaluation of alcohol withdrawal-induced inhibition of exploratory behaviour and supersensitivity to harmine-induced tremor.

    PubMed

    Meert, T F

    1994-01-01

    Rats given a liquid diet containing 10% (v/v) alcohol consume high quantities of alcohol. Within 8 hr after cessation of the alcohol intake, the animals will show alcohol-withdrawal reactions including a supersensitivity to harmine-induced tremor and an inhibition of exploratory behaviour in a neutral environment. Several drugs can overcome one or more of these alcohol-withdrawal reactions. A reduction of the alcohol withdrawal-induced inhibition of exploration, in terms of both the number of transits into the open field and the time spent in the open field, was obtained with chlordiazepoxide, ritanserin, mianserin and propranolol. Of these four compounds, propranolol and mianserin were also active against the supersensitivity to both 5.00 and 10.00 mg/kg harmine-induced tremor. Chlordiazepoxide and ritanserin were only active against 5.00 mg/kg harmine. Other compounds that reversed the supersensitivity to harmine-induced tremor during alcohol withdrawal included buspirone, fluoxetine, haloperidol, clonidine, flunarizine and baclofen. Very limited effects on both alcohol-withdrawal reactions were observed with ondansetron, nimodipine and MK-801. Risperidone and SCH 23390 were inactive. These results demonstrate that some alcohol withdrawal reactions can be studied in a systematic way and that various pharmacological agents can differentially interact with these alcohol withdrawal reactions.

  7. Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine.

    PubMed

    Vignoni, Mariana; Erra-Balsells, Rosa; Epe, Bernd; Cabrerizo, Franco M

    2014-03-05

    It is known that β-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine and 9-methyl-harmine under UVA irradiation in V79 cells, together with the associated generation of micronuclei and photocytotoxicity. The results indicate that the most frequent photoproducts generated in the cellular DNA are modified purines such as 8-oxo-7,8-dihydroguanine. Only relatively few single-strand breaks were observed. CPDs were absent, although they were generated in cell-free DNA irradiated under the same conditions. The overall extent of DNA damage in the cells was considerably smaller than the one observed in cell free DNA. The generation of cellular DNA damage was associated with a significant generation of micronuclei and decreased cell proliferation. The data indicate that β-carbolines act as photosensitizers in mammalian cells. The spectrum of DNA modification, and therefore the mechanism of DNA damage generation, differs considerably from that observed with cell-free DNA.

  8. Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis

    PubMed Central

    Nie, Tao; Hui, Xiaoyan; Mao, Liufeng; Nie, Baoming; Li, Kuai; Sun, Wei; Gao, Xuefei; Tang, Xiaofeng; Xu, Yong; Jiang, Baishan; Tu, Zhengcao; Li, Peng; Ding, Ke; Han, Weiping; Zhang, Shaoping; Xu, Aimin; Ding, Sheng; Liu, Pentao; Patterson, Adam; Cooper, Garth; Wu, Donghai

    2016-01-01

    Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we reveal that harmine antagonizes high fat diet-induced adiposity. Harmine-treated mice gained less weight on a high fat diet and displayed increased energy expenditure and adipose tissue thermogenesis. In vitro, harmine potently induced the expression of thermogenic genes in both brown and white adipocytes, which was largely abolished by inhibition of RAC1/MEK/ERK pathway. Post-transcriptional modification analysis revealed that chromodomain helicase DNA binding protein 4 (CHD4) is a potential downstream target of harmine-mediated ERK activation. CHD4 directly binds the proximal promoter region of Ucp1, which is displaced upon treatment of harmine, thereby serving as a negative modulator of Ucp1. Thus, here we reveal a new application of harmine in combating obesity via this off-target effect in adipocytes. PMID:27805061

  9. Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma

    PubMed Central

    2011-01-01

    Background Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells. Methods B16F-10 melanoma cells were treated in the presence and absence of harmine in vitro. Morphological changes, cell cycle and expression of various pro and anti- apoptotic genes were analyzed for the study of apoptosis. Results Morphological observation and DNA laddering assay showed that harmine treated cells displayed marked apoptotic characteristics, such as nuclear fragmentation, appearance of apoptotic bodies and DNA laddering fragment. TUNEL assay and flow cytometric analysis also confirmed apoptosis. Furthermore, RT-PCR analysis showed that harmine induced apoptosis in B16F-10 melanoma cells by up-regulating Bax and activating Caspase-3, 9 and p53 and down-regulating Bcl-2. Harmine also up-regulated Caspase-8 and Bid, indicating that harmine affected both extrinsic and intrinsic pathways of apoptosis. This study also showed inhibitory effects of harmine on some transcription factors and pro- inflammatory cytokines that protect cell from apoptosis. Conclusion Harmine activates both intrinsic and extrinsic pathways of apoptosis and regulates some transcription factors and pro-inflammatory cytokines. PMID:21429205

  10. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid ''Harmine''.

    PubMed

    Patel, K; Gadewar, M; Tripathi, R; Prasad, S K; Patel, Dinesh Kumar

    2012-08-01

    Harmine, a beta-carboline alkaloid, is widely distributed in the plants, marine creatures, insects, mammalians as well as in human tissues and body fluids. Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring. Harmine has various types of pharmacological activities such as antimicrobial, antifungal, antitumor, cytotoxic, antiplasmodial, antioxidaant, antimutagenic, antigenotoxic and hallucinogenic properties. It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor, enhances insulin sensitivity and also produces vasorelaxant effect. Harmine prevents bone loss by suppressing osteoclastogenesis. The current review gives an overview on pharmacological activity and analytical techniques of harmine, which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.

  11. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer

    PubMed Central

    2017-01-01

    Thyroid cancer is one of the most common types of cancer in endocrine system. In latest studies, harmine has been proved to inhibit the growth of several cancers in vitro and in vivo. In the current study, we evaluated the in vitro and in vivo anticancer efficiency of harmine against thyroid cancer cell line TPC-1. The in vitro cytotoxicity of harmine evaluated by XTT assay indicated that harmine suppressed the proliferation of TPC-1 cells in a dose- and time-dependent manner. Moreover, harmine dose-dependently induced apoptosis of TPC-1 cells through regulating the ratio of Bcl-2/Bax. The colony forming ability of TPC-1 cells was also time-dependently inhibited by harmine. The inhibitory effects of harmine on migration and invasion of TPC-1 cells were studied by wound scratching and Transwell assays. In vivo evaluation showed that harmine effectively inhibited the growth of thyroid cancer in a dose-dependent manner in nude mice. Therefore, harmine might be a promising herbal medicine in the therapy of thyroid cancer and further efforts are needed to explore this therapeutic strategy. PMID:28270853

  12. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury

    PubMed Central

    ZHONG, ZEQI; TAO, YUAN; YANG, HUI

    2015-01-01

    Traumatic brain injury (TBI) is a leading cause of mortality in young individuals, and results in motor and cognitive deficiency. Excitotoxicity is an important process during neuronal cell death, which is caused by excessive release of glutamate following TBI. Astrocytic glutamate transporters have a predominant role in maintaining extracellular glutamate concentrations below excitotoxic levels, and glutamate transporter 1 (GLT-1) may account for >90% of glutamate uptake in the brain. The β-carboline alkaloid harmine has been demonstrated to exert neuroprotective actions in vivo, and the beneficial effects were specifically due to elevation of GLT-1. However, whether harmine provides neuroprotection following TBI remains to be elucidated. The present study performed intraperitoneal harmine injections in rats (30 mg/kg per day for up to 5 days), in order to investigate whether harmine treatment attenuates brain edema and improves functional recovery in a rat model of TBI. The neuronal survival ratio and the protein expression of apoptosis-associated caspase 3 were also assessed in the hippocampus of the rat brain. Furthermore, the expression levels of GLT-1 and inflammatory cytokines were detected, in order to determine the underlying mechanisms. The results of the present study demonstrated that administration of harmine significantly attenuated cerebral edema, and improved learning and memory ability. In addition, harmine significantly increased the protein expression of GLT-1, and markedly attenuated the expression levels of interleukin-1β and tumor necrosis factor-α, thereby attenuating apoptotic neuronal death in the hippocampus. These results provided in vivo evidence that harmine may exert neuroprotective effects by synergistically reducing excitotoxicity and inflammation following TBI. PMID:26496827

  13. Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain

    PubMed Central

    Réus, Gislaine Z.; Stringari, Roberto B.; Gonçalves, Cinara L.; Scaini, Giselli; Carvalho-Silva, Milena; Jeremias, Gabriela C.; Jeremias, Isabela C.; Ferreira, Gabriela K.; Streck, Emílio L.; Hallak, Jaime E.; Zuardi, Antônio W.; Crippa, José A.; Quevedo, João

    2012-01-01

    The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg); harmine (15 mg/kg) decreased creatine kinase. In the chronic treatment occurred an increase of creatine kinase with imipramine (20 mg/kg), harmine (5 mg/kg) in the prefrontal with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg) in the striatum. In the acute treatment, the complex I increased in the prefrontal with harmine (15 mg/kg) and in the striatum with harmine (10 mg/kg); the complex II decreased with imipramine (20 and 30 mg/kg) in the striatum; the complex IV increased with imipramine (30 mg/kg) in the striatum. In the chronic treatment, the complex I increased with harmine (5 mg/kg) in the prefrontal; the complex II increased with imipramine (20 mg/kg) in the prefrontal; the complex IV increased with harmine (5 mg/kg) in the striatum. Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function. PMID:21969912

  14. The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells.

    PubMed

    Egusa, Hiroshi; Doi, Masanori; Saeki, Makio; Fukuyasu, Sho; Akashi, Yoshihiro; Yokota, Yoshifumi; Yatani, Hirofumi; Kamisaki, Yoshinori

    2011-08-01

    Small molecule compounds that potently affect osteoclastogenesis could be useful as chemical probes for elucidating the mechanisms of various biological phenomena and as effective therapeutic strategies against bone resorption. An osteoclast progenitor cell-based high-throughput screening system was designed to target activation of NFAT, which is a key event for osteoclastogenesis. Orphan ligand library screening using this system identified the β-carboline derivative harmine, which is a highly potent inhibitor of dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), to be an NFAT regulator in osteoclasts. RAW264.7 cells highly expressed DYRK1A protein, and in vitro phosphorylation assay demonstrated that harmine directly inhibited the DYRK1A-mediated phosphorylation (in-activation) of NFATc1. Harmine promoted the dephosphorylation (activation) of NFATc1 in RAW264.7 cells within 24h, and it significantly increased the expression of NFATc1 in RAW264.7 cells and mouse primary bone marrow macrophages (BMMs) both in the presence and absence of RANKL stimulation. Although harmine promoted NFATc1 expression and stimulated target genes for osteoclastogenesis, cell-cell fusion and the formation of TRAP-positive multinucleated osteoclasts from RAW264.7 cells and BMMs was significantly inhibited by harmine treatment. Meanwhile, harmine remarkably promoted the expression of inhibitor of DNA binding/differentiation-2 (Id2), which is a negative regulator for osteoclastogenesis, in RAW264.7 cells and BMMs. An Id2-null-mutant showed slightly increased osteoclast formation from BMMs, and the harmine-mediated inhibition of osteoclast formation was abolished in the BMMs of Id2-null-mutant mice. These results suggest that harmine is a potent activator of NFATc1 that interferes with the function of DYRK1A in osteoclast precursors and also up-regulates Id2 protein, which may dominantly inhibit expression pathways associated with cell-cell fusion, thereby leading to

  15. Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus

    PubMed Central

    Réus, Gislaine Z.; Stringari, Roberto B.; de Souza, Bruna; Petronilho, Fabrícia; Dal-Pizzol, Felipe; Hallak, Jaime E.; Zuardi, Antônio W.; Crippa, José A.; Quevedo, João

    2010-01-01

    A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine and harmine reduced lipid and protein oxidation, compared to control group in prefrontal cortex and hippocampus. The SOD and CAT activities increased with acute and chronic treatments with imipramine and harmine, compared to control group in prefrontal cortex and hippocampus. In conclusion, our results indicate positive effects of imipramine antidepressant and β-carboline harmine of oxidative stress parameters, increasing SOD and CAT activities and decreasing lipid and protein oxidation. PMID:21150338

  16. Novel 2DG-based harmine derivatives for targeted cancer therapy

    NASA Astrophysics Data System (ADS)

    Wang, Aqin; Chen, Yuqi; Chen, Wei R.; Gu, Yueqing

    2013-02-01

    Harmine is a beta-carboline alkaloid from the plant Peganum harmala. These alkaloids were stimulated by their promising antitumor activities in the recent years. In this study, we designed and synthesized two harmine derivatives #1and #2 modified at position-9 of harmine with ethyl and phenylpropyl, respectively. To improve the tumor targeting capability, #1' and #2' were synthesized by conjugating 2-amino-2-deoxy-D-glucose (2DG) to the derivatives #1 and #2, respectively. The MTT assays of all these compounds in vitro against L02, HepG2 showed all compounds had low toxicity to normal cells (L02) and significantly enhanced carcinoma cell inhibitory rate compared to harmine. Cytotoxicity against liver cancer cell lines of compound #1' #2' is higher than #1 #2, and even the compound #2' is better than positive drug 5-FU. The compound #2', a novel 2DG-based harmine derivatives, could become a promising drug for targeted cancer therapy and combination therapy with other antitumor drugs.

  17. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.

    PubMed

    Owaisat, Suzan; Raffa, Robert B; Rawls, Scott M

    2012-09-06

    Harmine is a β-carboline compound that targets glutamatergic, monoaminergic, and GABAergic pathways underlying drug addiction. We compared the efficacy of harmine against different psychoactive drugs using an invertebrate (planarian) assay designed to quantify 'C-shape' responses. Harmine itself (0.01-10 μM) did not produce C-shapes. However, when applied over the same concentration range, harmine significantly inhibited C-shapes elicited by cocaine, with a concentration of 0.1 μM producing almost 90% inhibition. Consistent with its putative actions, harmine produced a similar, though less efficacious, inhibition of C-shapes elicited by the substituted amphetamines methamphetamine and mephedrone (4-methylmethcathinone) but was much less effective against nicotine. When tested in the presence of the glutamate transporter inhibitor dihydrokainate (DHK) (0.1, 1 μM), harmine (0.1 μM) efficacy against cocaine-induced C-shapes was significantly reduced. Harmine also attenuated C-shapes elicited by N-methyl-d-aspartate (NMDA) and by glutamate itself. The present data suggest that harmine displays preferential efficacy against different addictive substances (cocaine>amphetamines>nicotine) and, at least for cocaine, is dependent on the glutamate system.

  18. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism

    PubMed Central

    Owaisat, Suzan; Raffa, Robert B.; Rawls, Scott M.

    2012-01-01

    Harmine is a β-carboline compound that targets glutamatergic, monoaminergic, and GABAergic pathways underlying drug addiction. We compared the efficacy of harmine against different psychoactive drugs using an invertebrate (planarian) assay designed to quantify ‘C-shape’ responses. Harmine itself (0.01 – 10 µM) did not produce C-shapes. However, when applied over the same concentration range, harmine significantly inhibited C-shapes elicited by cocaine, with a concentration of 0.1 µM producing almost 90% inhibition. Consistent with its putative actions, harmine produced a similar, though less efficacious, inhibition of C-shapes elicited by the substituted amphetamines methamphetamine and mephedrone (4-methylmethcathinone) but was much less effective against nicotine. When tested in the presence of the glutamate transporter inhibitor dihydrokainate (DHK) (0.1, 1 µM), harmine (0.1 µM) efficacy against cocaine-induced C-shapes was significantly reduced. Harmine also attenuated C-shapes elicited by N-methyl-D-aspartate (NMDA) and by glutamate itself. The present data suggest that harmine displays preferential efficacy against different addictive substances (cocaine > amphetamines > nicotine) and, at least for cocaine, is dependent on the glutamate system. PMID:22877698

  19. Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta.

    PubMed

    Berrougui, Hicham; Martín-Cordero, Carmen; Khalil, Abdelouahed; Hmamouchi, Mohammed; Ettaib, Abdelkader; Marhuenda, Elisa; Herrera, María Dolores

    2006-08-01

    The present work describes the mechanisms involved in the vasorelaxant effect of harmine and harmaline. These alkaloids induce in a dose-dependent manner the relaxation in the aorta precontracted with noradrenaline or KCl. However, the removal of endothelium or pre-treatment of intact aortic ring with L-NAME (inhibitor of NOSe synthetase) or with indomethacin (non-specific inhibitor of cyclo-oxygenase), reduces significantly the vasorelaxant response of harmaline but not harmine. According to their IC50 values, prazosin (inhibitor of alpha-adrenorecepteors) reduces the vasorelaxant effect only of harmaline, whereas, pre-treatment with IBMX (non-specific inhibitor of phosphodiesterase) affects both the harmaline and harmine-responses. Inhibitions of L-type voltage-dependent Ca2+ channels (VOCs) in endothelium-intact aortic rings with diltiazem depress the relaxation evoked by harmaline as well as by harmine. Pre-treatment with harmaline or harmine (3, 10 or 30 microM) shifted the phenylephrine-induced dose response curves to the right and the maximum response was attenuated indicating that the antagonist effect of both alkaloids on alpha1-adrenorecepteors was non-competitive. These two alkaloids also exert an antioxidant activity by scavenging the free radical generated by DPPH. Therefore, the present results suggest that the vasorelaxant effect of harmaline but not harmine is related to its action on the prostacyclin pathway and on the endothelial cells to release NO. However, both alkaloids can act as blockers VOCs, as inhibitors of phosphodiesterase resulting in an increase of the second messenger (cAMP and cGMP) levels and finally reduce the levels of free radicals in tissues.

  20. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells

    PubMed Central

    Zhang, Lei; Zhang, Fan; Zhang, Wenjun; Chen, Lu; Gao, Neng; Men, Yulong; Xu, Xiaojun; Jiang, Ying

    2015-01-01

    To avoid cell cycle arrest or apoptosis, rapidly proliferating cancer cells have to promote DNA double strand break (DSB) repair to fix replication stress induced DSBs. Therefore, developing drugs blocking homologous recombination (HR) and nonhomologous end joining (NHEJ) – 2 major DSB repair pathways – holds great potential for cancer therapy. Over the last few decades, much attention has been paid to explore drugs targeting DSB repair pathways for cancer therapy. Here, using 2 well-established reporters for analyzing HR and NHEJ efficiency, we found that both HR and NHEJ are elevated in hepatoma cell lines Hep3B and HuH7 compared with normal liver cell lines Chang liver and QSG-7701. Our further study found that Harmine, a natural compound, negatively regulates HR but not NHEJ by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine. Taken together, our study suggested that Harmine holds great promise as an oncologic drug and combination of Harmine with a NHEJ inhibitor might be an effective strategy for anti-cancer treatment. PMID:26382920

  1. Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy.

    PubMed

    Zhao, Ting; Zheng, Shan-Song; Zhang, Bin-Feng; Li, Yuan-Yuan; Bligh, S W Annie; Wang, Chang-Hong; Wang, Zheng-Tao

    2012-09-15

    The β-carboline alkaloids, harmaline and harmine, are present in hallucinogenic plants Ayahuasca and Peganum harmala, and in a variety of foods. In order to establish the metabolic pathway and bioactivities of endogenous and xenobiotic bioactive β-carbolines, high-performance liquid chromatography, coupled with mass spectrometry, was used to identify these metabolites in human liver microsomes (HLMs) in vitro and in rat urine and bile samples after oral administration of the alkaloids. Three metabolites of harmaline and two of harmine were found in the HLMs. Nine metabolites for harmaline and seven metabolites for harmine, from the rat urine and bile samples, were identified. Among them, four in vivo metabolites were isolated and fully characterised by NMR analysis. For the first time, harmaline is shown transforming to harmine by oxidative dehydrogenation in rat. Five metabolic pathways were therefore proposed, namely, oxidative dehydrogenation, 7-O-demethylation, hydroxylation, O-glucuronide conjugation and O-sulphate conjugation.

  2. HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.

    PubMed

    Kartal, M; Altun, M L; Kurucu, S

    2003-02-26

    A simple and sensitive method for separation and determination of harmol, harmalol, harmine and harmaline has been developed and validated. Harmol, harmalol, harmine and harmaline were separated using a Metasil ODS column by isocratic elution with flow rate 1.5 ml/min. The mobile phase composition was Isopropyl alcohol-Acetonitrile-Water-Formic acid (100:100:300:0.3) (v/v/v/v) and pH adjusted 8.6 with triethylamine. Spectrophotometric detection was carried out at 330 nm. The linear range of detection for harmol, harmalol, harmine and harmaline were between 9.375-250, 30.750-246, 31.250-500 and 31.000-248 microg/ml, respectively. The method described was suitable for the determination of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.

  3. Dietary effects of harmine, a β-carboline alkaloid, on development, energy reserves and α-amylase activity of Plodia interpunctella Hübner (Lepidoptera: Pyralidae)

    PubMed Central

    Bouayad, Noureddin; Rharrabe, Kacem; Lamhamdi, Mostafa; Nourouti, Naima Ghailani; Sayah, Fouad

    2010-01-01

    The physiological and developmental effects of harmine, a β-carboline alkaloid, on the insect pest Plodia interpunctella have been analyzed. When added at the larval diet, harmine induced a strong reduction of larvae weight, cannibalism between larvae, in addition to significant mortality. On the other hand, it caused a remarkable development disruption, manifested by both delay and reduction of pupation and adult emergence. Using spectrophotometric assays, we have shown that harmine ingestion provoked a severe reduction in protein, glycogen and lipid contents. Beside, when larvae fed harmine, the activity of the digestive enzyme α-amylase was strongly reduced. In conclusion, our experiments clearly show the susceptibility of P. interpunctella to harmine ingestion revealing the potent bioinsecticidal effect of harmine. PMID:23961164

  4. A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells.

    PubMed

    Dai, Fujun; Chen, Yihua; Song, Yajuan; Huang, Li; Zhai, Dong; Dong, Yanmin; Lai, Li; Zhang, Tao; Li, Dali; Pang, Xiufeng; Liu, Mingyao; Yi, Zhengfang

    2012-01-01

    Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy. Several classes of small-molecules that activate the p53 pathway have been discovered using various approaches. Here, we identified harmine (β-carboline alkaloid) as a novel activator of p53 signaling involved in inhibition of angiogenesis and tumor growth. Harmine induced p53 phosphorylation and disrupted the p53-MDM2 interaction. Harmine also prevented p53 degradation in the presence of cycloheximide and activated nuclear accumulation of p53 followed by increasing its transcriptional activity in endothelial cells. Moreover, harmine not only induced endothelial cell cycle arrest and apoptosis, but also suppressed endothelial cell migration and tube formation as well as induction of neovascularity in a mouse corneal micropocket assay. Finally, harmine inhibited tumor growth by reducing tumor angiogenesis, as demonstrated by a xenograft tumor model. Our results suggested a novel mechanism and bioactivity of harmine, which inhibited tumor growth by activating the p53 signaling pathway and blocking angiogenesis in endothelial cells.

  5. Spectroscopic and structural studies on the interaction of an anticancer β-carboline alkaloid, harmine with GC and AT specific DNA oligonucleotides.

    PubMed

    Sharma, Shweta; Yadav, Monika; Gupta, Surendra P; Pandav, Kumud; Kumar, Surat

    2016-12-25

    Harmine, a tricyclic β-carboline alkaloid possesses anticancer properties. Thus, its binding studies with DNA are considerably important because mechanism of action of anticancer drug involves DNA binding. On the other hand, the DNA binding study is also useful in drug designing and synthesis of new compounds with enhanced biological properties. Hence, the binding of harmine with sequence specific DNA oligonucleotides has been studied using various biophysical techniques i.e. absorption, fluorescence and molecular docking techniques. UV absorption study, Fluorescence quenching and Iodide quenching experiments revealed intercalation type of binding of harmine with short sequence specific DNA oligonucleotides. Fluorescence and absorption studies also concluded binding constants of harmine with GC rich DNA sequence in the order of 10(5) M(-1) while with AT rich sequences it was in the order of 10(3) M(-1) which clearly indicated that harmine showed greater intercalation with GC rich sequences as compared to AT rich sequences. From thermodynamic studies, it was concluded that harmine-DNA complex formation was spontaneous, exothermic and energetically favorable process. Molecular docking studies confirmed that harmine intercalates between the base pairs of DNA structure but energetically prefers intercalation between GC base pairs. Molecular docking studies and the calculated thermodynamic parameters, i.e. Gibbs free energy (ΔG), Enthalpy change (ΔH) and Entropy change (ΔS) indicated that H-bonds, van der Waals interactions and hydrophobic interactions play a major role in the binding of harmine to DNA oligomers.

  6. Structure-based design and synthesis of Harmine derivatives with different selectivity profiles in kinase vs monoamine oxidase inhibition.

    PubMed

    Balint, Balazs; Weber, Csaba; Cruzalegui, Francisco; Burbridge, Mike; Kotschy, Andras

    2017-03-06

    DYRK1A is an emerging biological target with implications in diverse therapeutic areas such as neurological disorders (Down syndrome in particular), metabolism, and oncology. Harmine, a natural product that selectively inhibits DYRK1A amongst kinases could serve as a tool compound to better understand the biological processes that arise from DYRK1A inhibition. On the other hand harmine is also a potent inhibitor of monoamine oxidase A (MAO-A). Using structure-based design we have synthesized a collection of harmine analogs with tunable selectivity towards these two enzymes. Modifications in position 7 typically decreased affinity for DYRK1A while substitution in position 9 had a similar effect on MAO-A inhibition while maintaining DYRK1A inhibition. The resulting collection of compounds can help to understand the biological role of DYRK1A and also to assess the interference in the biological effect originating in MAO-A inhibition.

  7. Short Communication: Evaluation of antimicrobial activities of Harmine, Harmaline, Nicotine and their complexes.

    PubMed

    Salman, Saad; Idrees, Fariha; Pervaiz, Sadia; Shah, Fahad Hassan; Badshah, Sareer; Abdullah; Usman, Mohammad; Halimi, Sm Ashhad; Idrees, Jawaria

    2016-07-01

    Harmine, Harmaline, Nicotine and its various complexes synthesized have been characterized by physical, spectral and analytical methods and curtained for in-vitro antimicrobial activity against different bacterial and fungal species at two different concentrations i.e.100μ/100µl and 200μ/100µl dose level respectively. Analysis showed that Nicotine, Zinc-Nico, Cd-Nico, Hg-Nico, Ni-Nico, Cu-Nico, Co-Nico, Harmine, and Harmaline having conc. of 100ug/ 100ul had antibacterial activity on zero, 5, 4, 10, zero, 5, 7, zero, zero strain of bacteria having an average of zero (SD=0.0000), 15.2000 (SD=1.30384), 18.2500 (SD=3.30404), 20.2000 (SD=1.39841), zero (SD=0.0000), 14.6000 (SD=0.89443), 15.8571 (SD=1.34519), zero (SD=0.0000), zero (SD=0.0000) respectively. Zinc (II) chloride, Cadmium (II) Iodide, Mercury (II) chloride, Nickel (II) chloride, Copper (II) chloride, Cobalt (II) chloride, Mercury (II) chloride, Mercury (II) harmine, Mercury (II) harmaline at 100ug/100ul is valid for 7, 8, 9, 2, 7, 8, 9, 10, 8 strains of bacteria with an average of 7.1429 (SD=1.06904), 10.0000 (SD=5.01427), 14.8889 (SD=6.00925), 6.0000 (SD=0.0000), 8.5714 (SD=4.27618), 8.2500 (SD=0.88641), 14.8889 (SD=6.00925), 18.6000 (SD=2.45855), 18.5000 (SD=1.85164) respectively. The above given compounds at the conc. of 200 μ/100ul is valid for 10, 9, 10, 8, 8, 10, 10, 10, 10 strains of bacteria with an average of 8.1 (SD=1.66333), 11.7778 (SD=5.28625), 16.1000 (SD=6.36745), 6.5000 (SD=0.92582), 9.7500 (SD=4.43203), 9.9000 (SD=2.76687), 16.1000 (SD=6.36745), 22.0000 (SD=2.44949), 20.4000 (SD=2.75681) respectively. The above given compounds at conc. of 200 μ/100ul showed antibacterial action on 3, 8, 8, 10, 3, 9, 8, zero, 3 strains of bacteria with an average of 14(SD=0.000), 16.8750 (SD=1.35620), 18.2500 (SD=3.45378), 22.7000 (SD=1.82878), 14.3333 (SD=0.57735), 16.7778 (SD=1.71594), zero (SD=0.000), 12.0000 (SD=1.00000) respectively. Hence according to the average value of the zone of inhibition

  8. Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies.

    PubMed

    Dos Santos, Rafael G; Hallak, Jaime E C

    2017-01-01

    Harmine is a natural β-carboline alkaloid found in several botanical species, such as the Banisteriopsis caapi vine used in the preparation of the hallucinogenic beverage ayahuasca and the seeds of Syrian rue (Peganum harmala). Preclinical studies suggest that harmine may have neuroprotective and cognitive-enhancing effects, and retrospective/observational investigations of the mental health of long-term ayahuasca users suggest that prolonged use of this harmine-rich hallucinogen is associated with better neuropsychological functioning. Thus, in order to better investigate these possibilities, we performed a systematic literature review of preclinical studies analyzing the effects of harmine on hippocampal neurons and in memory-related behavioral tasks in animal models. We found two studies involving hippocampal cell cultures and nine studies using animal models. Harmine administration was associated with neuroprotective effects such as reduced excitotoxicity, inflammation, and oxidative stress, and increased brain-derived neurotrophic factor (BDNF) levels. Harmine also improved memory/learning in several animal models. These effects seem be mediated by monoamine oxidase or acetylcholinesterase inhibition, upregulation of glutamate transporters, decreases in reactive oxygen species, increases in neurotrophic factors, and anti-inflammatory effects. The neuroprotective and cognitive-enhancing effects of harmine should be further investigated in both preclinical and human studies.

  9. Chemical structure and intra-molecular effects on NMR-NQR tensors of harmine and harmaline alkaloids

    NASA Astrophysics Data System (ADS)

    Ahmadinejad, Neda; Tahan, Arezoo; Talebi Tari, Mostafa

    2016-02-01

    Density functional theory (DFT) methods were used to analyze the effects of molecular structure and ring currents on the NMR chemical shielding tensors and NQR frequencies of harmine and harmaline alkaloids in the gas phase. The results demonstrated that NMR tensors and NQR frequencies of 15N nuclei in these compounds depend on chemical environment and resonance interactions. Hence, their values are obviously different in the mentioned structures. The interpretation of natural bond orbital (NBO) data suggests that in harmine structure, the lone pair participation of N9 in π-system electron clouds causes to development of aromaticity nature in pyrrole ring. However, the chemical shielding around N9 atom in harmine structure is higher than in harmaline, while in harmaline structure, lone pair participation of N2 in π-system electron clouds causes to development of aromaticity nature in pyridine ring. Hence, chemical shielding around N2 atom in harmaline structure is higher than in harmine. It can be deduced that by increasing lone pair electrons contribution of nitrogen atoms in ring resonance interactions and aromaticity development, the values of NMR chemical shielding around them increase, while χ and q zz values of these nuclei decrease.

  10. Genotoxic effects of the alkaloids harman and harmine assessed by comet assay and chromosome aberration test in mammalian cells in vitro.

    PubMed

    Boeira, J M; da Silva, J; Erdtmann, B; Henriques, J A

    2001-12-01

    Harman and harmine are beta-carboline alkaloids which are present in plants widely used in medical practice, in beverages used for religious purposes in Brazil, as well as in tobacco smoke and over cooked food. In view of the controversial results observed in the literature about the mutagenic effects of these alkaloids, we studied their cytotoxic and genotoxic effects in V79 Chinese hamster lung fibroblasts in vitro using single-cell gel assay, Comet assay, either in the presence or in absence of an exogenous metabolic activation system (S9-mix), and by the chromosome aberration test without S9-mix. Harmine was more cytotoxic than harman. Both harman and harmine increased aberrant cell frequency and induced DNA damage by the Comet assay. These results suggest that harman and harmine are genotoxic in V79 cells, probably as a consequence of their ability to induce DNA strand breaks.

  11. Cytotoxic and insecticidal activities of derivatives of harmine, a natural insecticidal component isolated from Peganum harmala.

    PubMed

    Zeng, Yong; Zhang, Yaomou; Weng, Qunfang; Hu, Meiying; Zhong, Guohua

    2010-11-02

    In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1,3-substituted β-carboline derivatives have been synthesized and evaluated for their cytotoxicity against insect cultured Sf9 cell line in vitro and insecticidal activities against 4th instar larvae of mosquitos, Culex pipiens quinquefasciatus and mustard aphid, Lipaphis erysimi. The results demonstrated that 1-phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (compound 2) and methyl 1-phenyl-β-carboline-3-carboxylate (compound 13) represented the best potential compounds, with Sf9 cells inhibition rates of 71.55% and 60.21% after 24 h treatment at concentrations of 50-200 mg/L, respectively. Both compounds 2 and 13 also showed strong insecticidal activity towards 4th instar larvae of mosquitos with LC(50) values of 20.82 mg/L and 23.98 mg/L, and their LC(90) values were 88.29 mg/L and 295.13 mg/L, respectively. Furthermore, the LC(50) values of compounds 2 and 13 against mustard aphids were 53.16 mg/L and 68.05 mg/L, and their LC(90) values were 240.10 mg/L and 418.63 mg/L after 48 h treatment. The in vitro cytotoxicity of these compounds was consistent with the insecticidal activity in vivo. The results indicated that the 1- and 3-positions of the β-carboline ring deserve further investigation to develop biorational insecticides based on the natural compound harmine as a lead compound.

  12. Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation.

    PubMed

    Berrougui, Hicham; Isabelle, Maxim; Cloutier, Martin; Hmamouchi, Mohammed; Khalil, Abdelouahed

    2006-07-01

    Oxidative modification of low-density lipoprotein (LDL) particles has been implicated in the process of atherogenesis. Antioxidants that prevent LDL from oxidation may reduce atherosclerosis. We have investigated the protective effect of Peganum harmala-extract (P-extract) and the two major alkaloids (harmine and harmaline) from the seeds of P. harmala against CuSO4-induced LDL oxidation. Through determination of the formation of malondialdehyde (MDA) and conjugated diene as well as the lag phase, the extract (P-extract) and compounds were found to possess an inhibitory effect. Moreover, harmaline and harmine reduced the rate of vitamin E disappearance and exhibited a significant free radical scavenging capacity (DPPH*). However, harmaline had a markedly higher antioxidant capacity than harmine in scavenging or preventive capacity against free radicals as well as inhibiting the aggregation of the LDL protein moiety (apolipoprotein B) induced by oxidation. The results suggested that P. harmala compounds could be a major source of compounds that inhibit LDL oxidative modification induced by copper.

  13. Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice.

    PubMed

    He, Dandan; Wu, Hui; Wei, Yue; Liu, Wei; Huang, Fei; Shi, Hailian; Zhang, Beibei; Wu, Xiaojun; Wang, Changhong

    2015-12-05

    Harmine, a β-carboline alkaloid present in Peganum harmala with a wide spectrum of pharmacological activities, has been shown to exert strong inhibition against acetylcholinesterase in vitro. However, whether it can rescue the impaired cognition has not been elucidated yet. In current study, we examined its effects on scopolamine-induced memory impairment mice and APP/PS1 transgenic mice, one of the models for Alzheimer's disease, using Morris Water Maze test. In addition, whether harmine could penetrate blood brain barrier, interact with and inhibit acetylcholinesterase, and activate downstream signaling network was also investigated. Our results showed that harmine (20mg/kg) administered by oral gavage for 2 weeks could effectively enhance the spatial cognition of C57BL/6 mice impaired by intraperitoneal injection of scopolamine (1mg/kg). Meanwhile, long-term consumption of harmine (20mg/kg) for 10 weeks also slightly benefited the impaired memory of APP/PS1 mice. Furthermore, harmine could pass through blood brain barrier, penetrate into the brain parenchyma shortly after oral administration, and modulate the expression of Egr-1, c-Jun and c-Fos. Molecular docking assay disclosed that harmine molecule could directly dock into the catalytic active site of acetylcholinesterase, which was partially confirmed by its in vivo inhibitory activity on acetylcholinesterase. Taken together, all these results suggested that harmine could ameliorate impaired memory by enhancement of cholinergic neurotransmission via inhibiting the activity of acetylcholinesterase, which may contribute to its clinical use in the therapy of neurological diseases characterized with acetylcholinesterase deficiency.

  14. Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.

    PubMed

    Liu, Jiming; Li, Qiang; Liu, Zhilong; Lin, Liuming; Zhang, Xiangqiang; Cao, Mingrong; Jiang, Jianwei

    2016-06-01

    Harmine, a β-carboline alkaloid isolated from the seeds of Peganum harmala, possesses both antitumor and anti‑nociceptive effects and inhibits human DNA topoisomerase. However, no detailed data are available concerning the mechanisms of harmine in human colorectal carcinoma SW620 cells. In the present study, we demonstrated that harmine inhibited the proliferation of SW620 cells in a dose-dependent manner using MTT and clone formation assays, and the IC50 value of harmine on the growth inhibition of SW620 cells for 48 h was 5.13 µg/ml. PI staining showed that harmine altered the cell cycle distribution by decreasing the proportion of cells in the G0-G1 phase and increasing the proportion in the S and G2-M phase. The expression level of cyclin D1 was decreased, while the expression of cyclin A, E2 and B1, CDK1/cdc2, Myt-1 and p-cdc2 (Tyr15) were increased, which was in accordance with the S and G2/M phase arrest. Hoechst 33258 staining revealed nuclear fragmentation, chromosomal condensation and cell shrinkage in the SW620 cells treated with harmine. Flow cytometry revealed that the percentage of apoptotic sub-G1 cells increased from 7.19 to 26.58%, while in the control group, sub-G1 cells only increased from 1.53 to 1.60%. Furthermore, early and late apoptotic cells were increased from 11.96 to 26.38% when incubated with the indicated concentration of harmine for 48 h, while in the control group, <8% of cells underwent apoptosis. JC-1 staining revealed that harmine decreased mitochondrial transmembrane potential (ΔΨm). The apoptosis of SW620 cells was also detected by western blot analysis, showing caspase-3 and -9, and PARP activation; the downregulation of Bcl-2, Mcl-1, Bcl-xL; and the upregulation of Bax. The expression of p-ERK, p-Akt (Ser473) and p-Akt (Thr308) was inhibited, and phosphorylation of downstream targets of Akt, such as p-FoxO3a and p-GSK‑3β were also attenuated. In conclusion, harmine induces cell cycle arrest and

  15. Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing

    PubMed Central

    Mennenga, Sarah E.; Gerson, Julia E.; Dunckley, Travis; Bimonte-Nelson, Heather A.

    2015-01-01

    Harmine is a naturally occurring monoamine oxidase inhibitor that has recently been shown to selectively inhibit the dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A). We investigated the cognitive effects of 1 mg (low) Harmine and 5 mg (high) Harmine using the delayed-match-to-sample (DMS) asymmetrical 3-choice water maze task to evaluate spatial working and recent memory, and the Morris water maze task (MM) to test spatial reference memory. Animals were also tested on the visible platform task, a water-escape task with the same motor, motivational, and reinforcement components as the other tasks used to evaluate cognition, but differing in its greater simplicity and that the platform was visible above the surface of the water. A subset of the Harmine-high treated animals showed clear motor impairments on all behavioral tasks, and the visible platform task confirmed a lack of competence to perform the procedural components of water maze testing. After excluding animals from the high dose group that could not perform the procedural components of a swim task, it was revealed that both high- and low-dose treatment with Harmine enhanced performance on the latter portion of DMS testing, but had no effect on MM performance. Thus, this study demonstrates the importance of confirming motor and visual competence when studying animal cognition, and verifies the one-day visible platform task as a reliable measure of ability to perform the procedural components necessary for completion of a swim task. PMID:25250831

  16. Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents

    PubMed Central

    Zhang, Xiao-Fei; Sun, Rong-qin; Jia, Yi-fan; Chen, Qing; Tu, Rong-Fu; Li, Ke-ke; Zhang, Xiao-Dong; Du, Run-Lei; Cao, Ri-hui

    2016-01-01

    A series of novel harmine derivatives bearing a benzylindine substituent in position-1 of β-carboline ring were synthesized and evaluated as antitumor agents. The N2-benzylated β-carboline derivatives 3a–g represented the most interesting anticancer activities and compound 3c was found to be the most active agent to diverse cancer cell lines such as gastric carcinoma, melanoma and colorectal cancer. Notably, compound 3c showed low toxicity to normal cells. The treatment significantly induced cell apoptosis. Mechanistically, PI3K/AKT signaling pathway mediated compound 3c-induced apoptosis. Compound 3c inhibited phosphorylation of AKT and promoted the production of reactive oxygen species (ROS). The ROS scavenger, LNAC and GSH, could disturb the effect of compound 3c induced apoptosis and PI3K activity inhibitor LY294002 synergistically enhanced compound 3c efficacy. Moreover, the results from nude mice xenograft model showed that compound 3c treatment effectively inhibited tumor growth and decreased tumor weight. Collectively, our results demonstrated that compound 3c exerts apoptotic effect in cancer cells via suppression of phosphorylated AKT and evocation of ROS generation, which suggested that compound 3c might be served as a promising therapeutic agent for cancer treatment. PMID:27625151

  17. Determination of Harmine and Harmaline in Peganum harmala Seeds by High-Performance Liquid Chromatography

    NASA Astrophysics Data System (ADS)

    Monsef-Esfahani, Hamid Reza; Faramarzi, Mohammad Ali; Mortezaee, Venus; Amini, Mohsen; Rouini, Mohammad Reza

    A High-Performance Liquid Chromatography (HPLC) method was developed for determination of harmine, harmaline, harmol and harmalol in the extract of Peganum harmala seeds. The sample preparation was performed using liquid-liquid extraction. Chromatographic separation was achieved with a Tracer Excel 120 ODSA (150x4.6 mm) column, using a mixture of potassium phosphate buffer (10 mM, pH 7.0): acetonitrile (100:30; v/v) as mobile phase, in an isocratic mode at 1.5 mL min-1. UV detection (λ = 330 nm) was used. The calibration curves were linear (r2>0.998) in the concentration range of 0.5-20 μg mL-1 for all analytes. The lower limit of quantification for all analytes was 0.5 μg mL-1. The within and between day precisions in the measurement of QC samples at three tested concentrations were in the range of 0.6-10.2% for all analytes. The HPLC method is able to measure the harmala alkaloids in the plant extract. The method has suitable reproducibility, sensitivity and resolution for routine and accurate use with UV detection.

  18. Separation and purification of harmine and harmaline from Peganum harmala using pH-zone-refining counter-current chromatography.

    PubMed

    Wang, Xiao; Geng, Yanling; Wang, Daijie; Shi, Xingang; Liu, Jianhua

    2008-10-01

    pH-zone-refining counter-current chromatography was successfully applied to the separation of alkaloids from a crude extract of Peganum harmala L. using a multilayer coil planet centrifuge. The experiment was performed with a two-phase solvent system composed of methyl tert-butyl ether/THF/water (2:2:3 by volume) where triethylamine (10 mM) was added to the upper organic stationary phase as a retainer and hydrochloric acid (5 mM) to the aqueous mobile phase as an eluter. From 1.2 g of the crude extract, 554 mg harmine and 325 mg harmaline were obtained each with a purity of over 96% as determined by HPLC. The structures of the isolated compounds were identified by electron ionization MS (EI-MS), (1)H NMR, and (13)C NMR.

  19. Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro

    PubMed Central

    Chen, Wei-liang; Yuan, Zhi-Qiang; Liu, Yang; Yang, Shu-di; Zhang, Chun-ge; Li, Ji-zhao; Zhu, Wen-jing; Li, Fang; Zhou, Xiao-feng; Lin, Yi-mei; Zhang, Xue-nong

    2016-01-01

    In this study, harmine liposomes (HM-lip) were prepared through the thin-film hydration–pH-gradient method and then coated with N-trimethyl chitosan (TMC). Particle size, zeta potential, entrapment efficiency, and in vitro release of HM-lip and TMC-coated harmine liposomes (TMC-HM-lip) were also determined. Sprague Dawley rats were further used to investigate the pharmacokinetics in vivo. Retention behavior in mouse gastrointestinal tract (GIT) was studied through high-performance liquid chromatography and near-infrared imaging. Degradation was further evaluated through incubation with Caco-2 cell homogenates, and a Caco-2 monolayer cell model was used to investigate the uptake and transport of drugs. HM-lip and TMC-HM-lip with particle size of 150–170 nm, an entrapment efficiency of about 81%, and a zeta potential of negative and positive, respectively, were prepared. The release of HM from HM-lip and TMC-HM-lip was slower than that from HM solution and was sensitive to pH. TMC-HM-lip exhibited higher oral bioavailability and had prolonged retention time in GIT. HM-lip and TMC-HM-lip could also protect HM against degradation in Caco-2 cell homogenates. The uptake amount of TMC-HM-lip was higher than that of HM and HM-lip. TMC-HM-lip further demonstrated higher apparent permeability coefficient (Papp) from the apical to the basolateral side than HM and HM-lip because of its higher uptake and capability to open tight junctions in the cell monolayers. TMC-HM-lip can prolong the retention time in the GIT, protect HM against enzyme degradation, and improve transport across Caco-2 cell monolayers, thus enhancing the oral bioavailability of HM. PMID:26855571

  20. High-performance thin-layer chromatography densitometric method for the quantification of harmine, harmaline, vasicine, and vasicinone in Peganum harmala.

    PubMed

    Pulpati, Harsha; Biradar, Yogesh S; Rajani, Mandapati

    2008-01-01

    Peganum harmala Linn. seed is a reputed drug of the Indian systems of medicine. We report a simple high-performance thin-layer chromatography (HPTLC) densitometric method for the quantification of 4 alkaloids, viz., harmine, harmaline, vasicine, and vasicinone from P. harmala seed. The 4 compounds were resolved in ethyl acetate-methanol-ammonia (7 + 1 + 0.3, v/v/v) mobile phase. The method was validated for precision, repeatability, and accuracy. Instrumental precision was 0.27, 1.53, 0.39, and 1.15% [relative standard deviation (RSD)] and repeatability of the method was 1.01, 0.79, 0.13, and 1.62% RSD for harmine, harmaline, vasicine, and vasicinone, respectively. Accuracy of the method was checked by a recovery study conducted at 3 different levels, and the average recovery was 97.88% for harmine, 97.69% for harmaline, 98.38% for vasicine, and 98.28% for vasicinone. The 4 compounds were quantified in P. harmala seed using the method, and it was found to contain 0.44, 0.096, 0.25, and 0.0007% (w/w) of each, respectively. The proposed HPTLC densitometric method for the quantification of the 4 compounds was found to be simple, precise, specific, sensitive, and accurate. It can be used for routine quality control of P. harmala seed and has the ability to quantify the 4 marker compounds in the formulations containing P. harmala. It also can be used to quantify any of these marker compounds in other herbal drugs.

  1. Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression

    PubMed Central

    SUN, KUN; TANG, XIAO-HE; XIE, YI-KUI

    2015-01-01

    Cyclooxygenase-2 (COX-2) has a critical role in the invasiveness and metastasis of gastric cancer. In addition, paclitaxel (PTX) and harmine (HM) were reported to be potential therapeutic drug candidates for cancer therapy; however, the synergistic antitumor effect of PTX and HM combined treatment on the human gastric cancer cells remains to be elucidated. The aim of the present study was to evaluate the effects of PTX and/or HM on the cell migration and invasion in two human gastric cancer cell lines, SGC-7901 and MKN-45. MTT assay was used to detect the growth inhibition induced by PTX and HM. The Transwell assay was employed to assess the effects of PTX and HM on the cell migration and invasion. The expression levels of COX-2 and matrix metalloproteinase-9 (MMP-9) were analyzed by western blot analysis. The results demonstrated that PTX and HM inhibited cell proliferation in a dose-dependent manner. Individually PTX and HM were able to inhibit the migration and invasion of two human gastric cancer cells; however, the combination of PTX and HM exerted synergistic effects on migration and invasion inhibition, with downregulation of COX-2 and matrix metalloproteinase (MMP)-9. In conclusion, the results of the present study indicated that combination chemotherapy using PTX with HM exerted an antitumor effect, which may be implicated for the treatment of gastric cancer. Of note, the combination of the two drugs inhibited migration and invasion more effectively compared with each drug alone, the mechanism of which proceeded via the downregulation of COX-2 expression. PMID:26622726

  2. Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [(11)C] Harmine Positron Emission Tomography Study.

    PubMed

    Kolla, Nathan J; Matthews, Brittany; Wilson, Alan A; Houle, Sylvain; Bagby, R Michael; Links, Paul; Simpson, Alexander I; Hussain, Amina; Meyer, Jeffrey H

    2015-10-01

    Antisocial personality disorder (ASPD) often presents with highly impulsive, violent behavior, and pathological changes in the orbitofrontal cortex (OFC) and ventral striatum (VS) are implicated. Several compelling reasons support a relationship between low monoamine oxidase-A (MAO-A), an enzyme that regulates neurotransmitters, and ASPD. These include MAO-A knockout models in rodents evidencing impulsive aggression and positron emission tomography (PET) studies of healthy subjects reporting associations between low brain MAO-A levels and greater impulsivity or aggression. However, a fundamental gap in the literature is that it is unknown whether brain MAO-A levels are low in more severe, clinical disorders of impulsivity, such as ASPD. To address this issue, we applied [(11)C] harmine PET to measure MAO-A total distribution volume (MAO-A VT), an index of MAO-A density, in 18 male ASPD participants and 18 age- and sex-matched controls. OFC and VS MAO-A VT were lower in ASPD compared with controls (multivariate analysis of variance (MANOVA): F2,33=6.8, P=0.003; OFC and VS MAO-A VT each lower by 19%). Similar effects were observed in other brain regions: prefrontal cortex, anterior cingulate cortex, dorsal putamen, thalamus, hippocampus, and midbrain (MANOVA: F7,28=2.7, P=0.029). In ASPD, VS MAO-A VT was consistently negatively correlated with self-report and behavioral measures of impulsivity (r=-0.50 to -0.52, all P-values<0.05). This study is the first to demonstrate lower brain MAO-A levels in ASPD. Our results support an important extension of preclinical models of impulsive aggression into a human disorder marked by pathological aggression and impulsivity.

  3. Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

    PubMed Central

    Kolla, Nathan J; Matthews, Brittany; Wilson, Alan A; Houle, Sylvain; Michael Bagby, R; Links, Paul; Simpson, Alexander I; Hussain, Amina; Meyer, Jeffrey H

    2015-01-01

    Antisocial personality disorder (ASPD) often presents with highly impulsive, violent behavior, and pathological changes in the orbitofrontal cortex (OFC) and ventral striatum (VS) are implicated. Several compelling reasons support a relationship between low monoamine oxidase-A (MAO-A), an enzyme that regulates neurotransmitters, and ASPD. These include MAO-A knockout models in rodents evidencing impulsive aggression and positron emission tomography (PET) studies of healthy subjects reporting associations between low brain MAO-A levels and greater impulsivity or aggression. However, a fundamental gap in the literature is that it is unknown whether brain MAO-A levels are low in more severe, clinical disorders of impulsivity, such as ASPD. To address this issue, we applied [11C] harmine PET to measure MAO-A total distribution volume (MAO-A VT), an index of MAO-A density, in 18 male ASPD participants and 18 age- and sex-matched controls. OFC and VS MAO-A VT were lower in ASPD compared with controls (multivariate analysis of variance (MANOVA): F2,33=6.8, P=0.003; OFC and VS MAO-A VT each lower by 19%). Similar effects were observed in other brain regions: prefrontal cortex, anterior cingulate cortex, dorsal putamen, thalamus, hippocampus, and midbrain (MANOVA: F7,28=2.7, P=0.029). In ASPD, VS MAO-A VT was consistently negatively correlated with self-report and behavioral measures of impulsivity (r=−0.50 to −0.52, all P-values<0.05). This study is the first to demonstrate lower brain MAO-A levels in ASPD. Our results support an important extension of preclinical models of impulsive aggression into a human disorder marked by pathological aggression and impulsivity. PMID:26081301

  4. Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice.

    PubMed

    Biradar, S M; Joshi, Hanumanthachar; Tarak, K C

    2013-12-01

    The aim of the study was to isolate the harmine alkaloids from the seeds of Peganum harmala (TAPH) and its cerebroprotective effect on cognitive deficit mice. The tested doses of TAPH were screened for Sodium nitrite induced hypoxia and Ethanol induced neurodegeneration using behavioral models. The TAPH was found to be non-neurotoxic and Psychoactive by preventing the motor impairment and increasing the locomotion activity of animals in Rota rod and Actophotometer respectively. TAPH (5, 2.5 and 1.25 mg kg(-1) p.o.) significantly (p < 0.001) protected the Sodium nitrite induced memory impairment by decreasing the time require to find the water bottle in special water bottle case model. In Elevated Plus Maze (EPM) and Passive Shock Avoidance paradigm (PSA) the TAPH shown improved acquisition and retention memory significantly (p < 0.001) by decreasing the Transverse Latency Time (TLT) and increasing the Step Down Latency (SDL), respectively in dose dependent manner. The results were well supported by biochemical parameters, by inhibiting the Acetylcholinestrase (p < 0.01) activity, increasing the GSH (p < 0.001) level and decreasing the TBARS (p < 0.001) level of whole brain. Moreover TAPH has shown the significant Monoamine oxidase-A (MAO-A) inhibition action (p < 0.001), hence it reduces the metabolism of epinephrine, 5-HT and other monoamines and enhances the action of these neurotransmitters indirectly; this adrenergic system plays an important role in learning and memory. Further, TAPH (5 mg kg(-1)) protect the DNA fragmentation of frontotemporal cortex of the brain from hypoxic effect induced by Sodium nitrite in Gel Electrophoresis studies. The results were comparable to their respective standards. Hence, harmine alkaloids are potential enough to utilize in the management of Neurodegenerative disorders of the type Alzheimer's diseases.

  5. Preparation and characterization of a new harmine-based antiproliferative compound in complex with cyclodextrin: Increasing solubility while maintaining biological activity.

    PubMed

    Meinguet, Céline; Masereel, Bernard; Wouters, Johan

    2015-09-18

    The trisubstituted harmine derivative, 2, present a submicromolar antiproliferative activity on 5 cancer cell lines but a moderate kinetic solubility in pH 7.4 buffer. The aim of this work was to develop a 2-cyclodextrin complex in order to increase the drug solubility while maintaining the biological activity. Firstly, the 2 increasing solubility in presence of several cyclodextrins (CDs) has been shown, with a maximum for 7 glucose subunit CD (βCD and 2 HP-βCD). Phase solubility experiment in presence of 2 HP-βCD has underline an AL-type profile until 80 mM which suggest a 1:1 stoichiometry and a K1:1 of 116 M(-1) and a CE of 0.28 have been calculated. This 1:1 stoichiometry was confirmed by Job Plot experiment, following the CD H-3 proton by (1)H NMR. Secondly, (1)H NMR study of compound 2 in presence of βCD and geometry optimization of the complex has underline an inclusion of 2 into the CD, via the indole part of the drug. Finally, the efficiency of the 2 antiproliferative effect is not affected by the complexation, as shown by viability test.

  6. Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

    PubMed Central

    Yu, Xiao-Juan; Sun, Kun; Tang, Xiao-He; Zhou, Cun-Jin; Sun, Hui; Yan, Zhe; Fang, Ling; Wu, Hong-Wen; Xie, Yi-Kui; Gu, Bin

    2016-01-01

    Cyclooxygenase-2 (COX-2) serves an important role in the carcinogenesis and progression of gastric cancer. Harmine (HM) and paclitaxel (PTX) are reported as promising drug candidates for cancer therapy, but whether a synergistic anti-tumor effect of HM combined with PTX exists in human gastric cancer remains unknown. The present study evaluated the effects of HM and/or PTX on cell proliferation and apoptosis in a gastric cancer cell line, SGC-7901. HM and PTX inhibited cell proliferation in a dose-dependent manner. Both HM and PTX alone induced apoptosis in gastric cancer cells. The combination of HM and PTX exerted synergistic effects on proliferation inhibition and apoptosis induction in SGC-7901 cells, with down-regulation of COX-2, PCNA and Bcl-2 and up-regulation of Bax expression. The results indicated that combination chemotherapy using HM with PTX exerts an anti-tumor effect for treating gastric cancer. The combination of the two drugs inhibits gastric cancer development more effectively than each drug alone through down-regulation of COX-2 expression. PMID:27446381

  7. Simultaneous determination of harmine, harmaline and their metabolites harmol and harmalol in beagle dog plasma by UPLC-ESI-MS/MS and its application to a pharmacokinetic study.

    PubMed

    Zhang, Lei; Teng, Liang; Gong, Can; Liu, Wei; Cheng, Xuemei; Gu, Shenghua; Deng, Zhongping; Wang, Zhengtao; Wang, Changhong

    2013-11-01

    Harmine (HAR) and harmaline (HAL) were metabolized by demethylation to form harmol (HOL) and harmalol (HAM) both in vivo and in vitro. It has been demonstrated tremendous value of HAR, HAL and their metabolites in the therapy of Alzheimer's disease. A rapid, selective and sensitive UPLC-ESI-MS/MS method was firstly developed and validated for the simultaneous determination of HAR, HAL, HOL, and HAM in beagle dog plasma with 9-aminoacridine as the internal standard (IS). After protein precipitation with acetonitrile, the analytes were separated within 4.5 min on an ACQUITY UPLC BEH C18 column with a gradient elution system composed of 0.1% formic acid and acetonitrile at a flow rate of 0.4 ml/min. Detection was performed using multiple reactions monitoring mode under a positive ionization condition. The calibration curves of four analytes showed good linearity (r(2)>0.9959) within the tested concentration ranges. The low limit of quantification for HAR, HAL, HOL, and HAM were all 1.00 ng/ml. The mean accuracy of the analytes was within the range of 94.56-112.23%, the R.S.D. values of intra-day and the inter-day precision were less than 6.26% and 7.51%, respectively. Matrix effects and extraction recoveries of the analytes from the beagle dog plasma were within the range of 94.48-105.77% and 89.07-101.44%, respectively. The validated method was successfully applied to a pharmacokinetic study of HAR, HAL, HOL, and HAM in beagle dogs after intravenous administration of HAR and HAL both of 1.0mg/kg. The main pharmacokinetic parameters of Cmax, Vd, CL, AUC and MRT, except Ke and t1/2 values, showed significant difference between the two parent drug HAR and HAL, respectively (p<0.05-0.001). Because of the different metabolic rate of HAR and HAL in vivo, the two metabolites, HOL and HAM, exhibited unique pharmacokinetic properties.

  8. Pump apparatus including deconsolidator

    DOEpatents

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  9. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  10. Including Jews in Multiculturalism.

    ERIC Educational Resources Information Center

    Langman, Peter F.

    1995-01-01

    Discusses reasons for the lack of attention to Jews as an ethnic minority within multiculturalism both by Jews and non-Jews; why Jews and Jewish issues need to be included; and addresses some of the issues involved in the ethical treatment of Jewish clients. (Author)

  11. Nutritional therapies (including fosteum).

    PubMed

    Nieves, Jeri W

    2009-03-01

    Nutrition is important in promoting bone health and in managing an individual with low bone mass or osteoporosis. In adult women and men, known losses of bone mass and microarchitecture occur, and nutrition can help minimize these losses. In every patient, a healthy diet with adequate protein, fruits, vegetables, calcium, and vitamin D is required to maintain bone health. Recent reports on nutritional remedies for osteoporosis have highlighted the importance of calcium in youth and continued importance in conjunction with vitamin D as the population ages. It is likely that a calcium intake of 1200 mg/d is ideal, and there are some concerns about excessive calcium intakes. However, vitamin D intake needs to be increased in most populations. The ability of soy products, particularly genistein aglycone, to provide skeletal benefit has been recently studied, including some data that support a new medical food marketed as Fosteum (Primus Pharmaceuticals, Scottsdale, AZ).

  12. Refraction, including prisms.

    PubMed

    Hiatt, R L

    1991-02-01

    The literature in the past year on refraction is replete with several isolated but very important topics that have been of interest to strabismologists and refractionists for many decades. The refractive changes in scleral buckling procedures include an increase in axial length as well as an increase in myopia, as would be expected. Tinted lenses in dyslexia show little positive effect in the nonasthmatic patients in one study. The use of spectacles or bifocals as a way to control increase in myopia is refuted in another report. It has been shown that in accommodative esotropia not all patients will be able to escape the use of bifocals in the teenage years, even though surgery might be performed. The hope that disposable contact lenses would cut down on the instance of giant papillary conjunctivitis and keratitis has been given some credence, and the conventional theory that sclerosis alone is the cause of presbyopia is attacked. Also, gas permeable bifocal contact lenses are reviewed and the difficulties of correcting presbyopia by this method outlined. The practice of giving an aphakic less bifocal addition instead of a nonaphakic, based on the presumption of increased effective power, is challenged. In the review of prisms, the majority of articles concern prism adaption. The most significant report is that of the Prism Adaptation Study Research Group (Arch Ophthalmol 1990, 108:1248-1256), showing that acquired esotropia in particular has an increased incidence of stable and full corrections surgically in the prism adaptation group versus the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Environmental Sustainability - Including Land and Water Use

    EPA Science Inventory

    Assessments of environmental sustainability can be conducted in many ways with one of the most quantitative methods including Life Cycle Impact Assessment (LCIA). While historically LCIA has included a comprehensive list of impact categories including: ozone depletion, global c...

  14. Haemophilus influenzae Disease (Including Hib) Symptoms

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Haemophilus influenzae Disease (Including Hib) Note: Javascript is disabled or ... and Symptoms Recommend on Facebook Tweet Share Compartir Haemophilus influenzae , including Hib, disease causes different symptoms depending on ...

  15. Article Including Environmental Barrier Coating System

    NASA Technical Reports Server (NTRS)

    Lee, Kang N. (Inventor)

    2015-01-01

    An enhanced environmental barrier coating for a silicon containing substrate. The enhanced barrier coating may include a bond coat doped with at least one of an alkali metal oxide and an alkali earth metal oxide. The enhanced barrier coating may include a composite mullite bond coat including BSAS and another distinct second phase oxide applied over said surface.

  16. Composite Pressure Vessel Including Crack Arresting Barrier

    NASA Technical Reports Server (NTRS)

    DeLay, Thomas K. (Inventor)

    2013-01-01

    A pressure vessel includes a ported fitting having an annular flange formed on an end thereof and a tank that envelopes the annular flange. A crack arresting barrier is bonded to and forming a lining of the tank within the outer surface thereof. The crack arresting barrier includes a cured resin having a post-curing ductility rating of at least approximately 60% through the cured resin, and further includes randomly-oriented fibers positioned in and throughout the cured resin.

  17. 47 CFR 1.9005 - Included services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Included services. 1.9005 Section 1.9005 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Spectrum Leasing Scope and Authority § 1.9005 Included services. The spectrum leasing policies and rules of this subpart apply to...

  18. 47 CFR 1.9005 - Included services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Included services. 1.9005 Section 1.9005 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Spectrum Leasing Scope and Authority § 1.9005 Included services. The spectrum leasing policies and rules...

  19. 47 CFR 1.9005 - Included services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Included services. 1.9005 Section 1.9005 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Spectrum Leasing Scope and Authority § 1.9005 Included services. The spectrum leasing policies and rules...

  20. 47 CFR 1.9005 - Included services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Included services. 1.9005 Section 1.9005 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Spectrum Leasing Scope and Authority § 1.9005 Included services. The spectrum leasing policies and rules of this subpart apply to...

  1. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  2. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  3. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  4. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  5. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  6. Server-Side Includes Made Simple.

    ERIC Educational Resources Information Center

    Fagan, Jody Condit

    2002-01-01

    Describes server-side include (SSI) codes which allow Webmasters to insert content into Web pages without programming knowledge. Explains how to enable the codes on a Web server, provides a step-by-step process for implementing them, discusses tags and syntax errors, and includes examples of their use on the Web site for Southern Illinois…

  7. 47 CFR 1.9005 - Included services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Spectrum Leasing Scope and Authority § 1.9005 Included services. Link to an amendment published at 79 FR 48533, August 15, 2014. The spectrum leasing policies and rules of this subpart apply to the...

  8. 42 CFR 410.100 - Included services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... function or dysfunction of the neuromuscular, musculoskeletal, cardiovascular and respiratory systems; and... create difficulties in communication. (e) Respiratory therapy services. (1) Respiratory therapy services... cardiopulmonary function. (2) Respiratory therapy services include the following: (i) Application of...

  9. 42 CFR 410.100 - Included services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... function or dysfunction of the neuromuscular, musculoskeletal, cardiovascular and respiratory systems; and... create difficulties in communication. (e) Respiratory therapy services. (1) Respiratory therapy services... cardiopulmonary function. (2) Respiratory therapy services include the following: (i) Application of...

  10. 42 CFR 410.100 - Included services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... function or dysfunction of the neuromuscular, musculoskeletal, cardiovascular and respiratory systems; and... create difficulties in communication. (e) Respiratory therapy services. (1) Respiratory therapy services... cardiopulmonary function. (2) Respiratory therapy services include the following: (i) Application of...

  11. 42 CFR 410.100 - Included services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... function or dysfunction of the neuromuscular, musculoskeletal, cardiovascular and respiratory systems; and... create difficulties in communication. (e) Respiratory therapy services. (1) Respiratory therapy services... cardiopulmonary function. (2) Respiratory therapy services include the following: (i) Application of...

  12. 42 CFR 410.100 - Included services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... function or dysfunction of the neuromuscular, musculoskeletal, cardiovascular and respiratory systems; and... create difficulties in communication. (e) Respiratory therapy services. (1) Respiratory therapy services... cardiopulmonary function. (2) Respiratory therapy services include the following: (i) Application of...

  13. Include Passive Solar in Your Renovations.

    ERIC Educational Resources Information Center

    Bender, Gerald F.; Probasco, Jack F.

    1981-01-01

    A checklist covers potential energy saving modifications in a building scheduled for renovation, and includes suggestions for room utilization, landscaping, and building envelope, solar control, and active system modifications. (Author)

  14. Lung Disease Including Asthma and Adult Vaccination

    MedlinePlus

    ... Healthcare Professionals Lung Disease including Asthma and Adult Vaccination Language: English Español (Spanish) Recommend on Facebook Tweet ... more about health insurance options. Learn about adult vaccination and other health conditions Asplenia Diabetes Heart Disease, ...

  15. Communications circuit including a linear quadratic estimator

    DOEpatents

    Ferguson, Dennis D.

    2015-07-07

    A circuit includes a linear quadratic estimator (LQE) configured to receive a plurality of measurements a signal. The LQE is configured to weight the measurements based on their respective uncertainties to produce weighted averages. The circuit further includes a controller coupled to the LQE and configured to selectively adjust at least one data link parameter associated with a communication channel in response to receiving the weighted averages.

  16. Gas storage materials, including hydrogen storage materials

    DOEpatents

    Mohtadi, Rana F; Wicks, George G; Heung, Leung K; Nakamura, Kenji

    2014-11-25

    A material for the storage and release of gases comprises a plurality of hollow elements, each hollow element comprising a porous wall enclosing an interior cavity, the interior cavity including structures of a solid-state storage material. In particular examples, the storage material is a hydrogen storage material, such as a solid state hydride. An improved method for forming such materials includes the solution diffusion of a storage material solution through a porous wall of a hollow element into an interior cavity.

  17. Gas storage materials, including hydrogen storage materials

    DOEpatents

    Mohtadi, Rana F; Wicks, George G; Heung, Leung K; Nakamura, Kenji

    2013-02-19

    A material for the storage and release of gases comprises a plurality of hollow elements, each hollow element comprising a porous wall enclosing an interior cavity, the interior cavity including structures of a solid-state storage material. In particular examples, the storage material is a hydrogen storage material such as a solid state hydride. An improved method for forming such materials includes the solution diffusion of a storage material solution through a porous wall of a hollow element into an interior cavity.

  18. Eddy Resolving Global Ocean Prediction including Tides

    DTIC Science & Technology

    2013-09-30

    tensor scheme reduced at supercritical slopes, and their scalar sisters, a Nycander scalar limited in shallow water , and the Jayne and St. Laurent [2001...NAVOCEANO) starting in FY14. The model will include shallow water and provide boundary conditions to finer resolution coastal models that may use HYCOM or a...latter out to 30 days in many deep water regions, including regions of high Navy interest such as the Western Pacific and the Arabian Sea/Gulf of

  19. Weather information network including graphical display

    NASA Technical Reports Server (NTRS)

    Leger, Daniel R. (Inventor); Burdon, David (Inventor); Son, Robert S. (Inventor); Martin, Kevin D. (Inventor); Harrison, John (Inventor); Hughes, Keith R. (Inventor)

    2006-01-01

    An apparatus for providing weather information onboard an aircraft includes a processor unit and a graphical user interface. The processor unit processes weather information after it is received onboard the aircraft from a ground-based source, and the graphical user interface provides a graphical presentation of the weather information to a user onboard the aircraft. Preferably, the graphical user interface includes one or more user-selectable options for graphically displaying at least one of convection information, turbulence information, icing information, weather satellite information, SIGMET information, significant weather prognosis information, and winds aloft information.

  20. Transmission line including support means with barriers

    DOEpatents

    Cookson, Alan H.

    1982-01-01

    A gas insulated transmission line includes an elongated outer sheath, a plurality of inner conductors disposed within and extending along the outer sheath, and an insulating gas which electrically insulates the inner conductors from the outer sheath. A support insulator insulatably supports the inner conductors within the outer sheath, with the support insulator comprising a main body portion including a plurality of legs extending to the outer sheath, and barrier portions which extend between the legs. The barrier portions have openings therein adjacent the main body portion through which the inner conductors extend.

  1. Electric Power Monthly, August 1990. [Glossary included

    SciTech Connect

    Not Available

    1990-11-29

    The Electric Power Monthly (EPM) presents monthly summaries of electric utility statistics at the national, Census division, and State level. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data includes generation by energy source (coal, oil, gas, hydroelectric, and nuclear); generation by region; consumption of fossil fuels for power generation; sales of electric power, cost data; and unusual occurrences. A glossary is included.

  2. 47 CFR 65.820 - Included items.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Included items. 65.820 Section 65.820 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) INTERSTATE RATE...) Cash working capital. The average amount of investor-supplied capital needed to provide funds for...

  3. Parachute Line Hook Includes Integral Loop Expander

    NASA Technical Reports Server (NTRS)

    Bayless, G. B.

    1983-01-01

    Parachute packing simplified with modified line hook. One person packs parachutes for test recovery vehicles faster than previously two-person team. New line hook includes expander that opens up two locking loops so parachute lines are pulled through them. Parachutes are packed at high pressure to be compressed into limited space available in test vehicles.

  4. Including Students with Visual Impairments: Softball

    ERIC Educational Resources Information Center

    Brian, Ali; Haegele, Justin A.

    2014-01-01

    Research has shown that while students with visual impairments are likely to be included in general physical education programs, they may not be as active as their typically developing peers. This article provides ideas for equipment modifications and game-like progressions for one popular physical education unit, softball. The purpose of these…

  5. Including the Excluded: One School for All.

    ERIC Educational Resources Information Center

    EFA 2000 Bulletin, 1998

    1998-01-01

    This issue of "EFA 2000" focuses on the theme of inclusive education, i.e., including children with disabilities in general education classrooms. The cover story discusses a 1995 UNESCO survey of 63 countries that showed that integration of children with disabilities in regular schools is a declared policy in almost every country.…

  6. Effects of Including Humor in Test Items.

    ERIC Educational Resources Information Center

    McMorris, Robert F.; And Others

    Two 50-item multiple-choice forms of a grammar test were developed differing only in humor being included in 20 items of one form. One hundred twenty-six (126) eighth graders received the test plus alternate forms of a questionnaire. Humor inclusion did not affect grammar scores on matched humorous/nonhumorous items nor on common post-treatment…

  7. Nuclear Chemistry: Include It in Your Curriculum.

    ERIC Educational Resources Information Center

    Atwood, Charles H.; Sheline, R. K.

    1989-01-01

    Some of the topics that might be included in a nuclear chemistry section are explored. Offers radioactivity, closed shells in nuclei, energy of nuclear processes, nuclear reactions, and fission and fusion as topics of interest. Provided are ideas and examples for each. (MVL)

  8. 34 CFR 300.20 - Include.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Include. 300.20 Section 300.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

  9. 34 CFR 300.20 - Include.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Include. 300.20 Section 300.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

  10. 34 CFR 300.20 - Include.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include. 300.20 Section 300.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

  11. A group of VIPs, including Orville Wright

    NASA Technical Reports Server (NTRS)

    1939-01-01

    A group of VIPs, including Orville Wright, center. Left to right bottom row ?, Walter Reiser, Elton Miller, Orville Wright, Starr Truscutt, Addison Rothrock, Eastman Jacobs, Dr. Lewis Top row Gus Crowley, Ernie Johnson, Carlton Kemper, H.J.E. Reid, Smith DeFrance, Theodore Theodorsen.

  12. Dynamic Analyses Including Joints Of Truss Structures

    NASA Technical Reports Server (NTRS)

    Belvin, W. Keith

    1991-01-01

    Method for mathematically modeling joints to assess influences of joints on dynamic response of truss structures developed in study. Only structures with low-frequency oscillations considered; only Coulomb friction and viscous damping included in analysis. Focus of effort to obtain finite-element mathematical models of joints exhibiting load-vs.-deflection behavior similar to measured load-vs.-deflection behavior of real joints. Experiments performed to determine stiffness and damping nonlinearities typical of joint hardware. Algorithm for computing coefficients of analytical joint models based on test data developed to enable study of linear and nonlinear effects of joints on global structural response. Besides intended application to large space structures, applications in nonaerospace community include ground-based antennas and earthquake-resistant steel-framed buildings.

  13. Photoactive devices including porphyrinoids with coordinating additives

    DOEpatents

    Forrest, Stephen R; Zimmerman, Jeramy; Yu, Eric K; Thompson, Mark E; Trinh, Cong; Whited, Matthew; Diev, Vlacheslav

    2015-05-12

    Coordinating additives are included in porphyrinoid-based materials to promote intermolecular organization and improve one or more photoelectric characteristics of the materials. The coordinating additives are selected from fullerene compounds and organic compounds having free electron pairs. Combinations of different coordinating additives can be used to tailor the characteristic properties of such porphyrinoid-based materials, including porphyrin oligomers. Bidentate ligands are one type of coordinating additive that can form coordination bonds with a central metal ion of two different porphyrinoid compounds to promote porphyrinoid alignment and/or pi-stacking. The coordinating additives can shift the absorption spectrum of a photoactive material toward higher wavelengths, increase the external quantum efficiency of the material, or both.

  14. SKIRT: Stellar Kinematics Including Radiative Transfer

    NASA Astrophysics Data System (ADS)

    Baes, Maarten; Dejonghe, Herwig; Davies, Jonathan

    2011-09-01

    SKIRT is a radiative transfer code based on the Monte Carlo technique. The name SKIRT, acronym for Stellar Kinematics Including Radiative Transfer, reflects the original motivation for its creation: it has been developed to study the effects of dust absorption and scattering on the observed kinematics of dusty galaxies. In a second stage, the SKIRT code was extended with a module to self-consistently calculate the dust emission spectrum under the assumption of local thermal equilibrium. This LTE version of SKIRT has been used to model the dust extinction and emission of various types of galaxies, as well as circumstellar discs and clumpy tori around active galactic nuclei. A new, extended version of SKIRT code can perform efficient 3D radiative transfer calculations including a self-consistent calculation of the dust temperature distribution and the associated FIR/submm emission with a full incorporation of the emission of transiently heated grains and PAH molecules.

  15. Rotor assembly including superconducting magnetic coil

    DOEpatents

    Snitchler, Gregory L.; Gamble, Bruce B.; Voccio, John P.

    2003-01-01

    Superconducting coils and methods of manufacture include a superconductor tape wound concentrically about and disposed along an axis of the coil to define an opening having a dimension which gradually decreases, in the direction along the axis, from a first end to a second end of the coil. Each turn of the superconductor tape has a broad surface maintained substantially parallel to the axis of the coil.

  16. Power generation method including membrane separation

    DOEpatents

    Lokhandwala, Kaaeid A.

    2000-01-01

    A method for generating electric power, such as at, or close to, natural gas fields. The method includes conditioning natural gas containing C.sub.3+ hydrocarbons and/or acid gas by means of a membrane separation step. This step creates a leaner, sweeter, drier gas, which is then used as combustion fuel to run a turbine, which is in turn used for power generation.

  17. Nuclear reactor shield including magnesium oxide

    DOEpatents

    Rouse, Carl A.; Simnad, Massoud T.

    1981-01-01

    An improvement in nuclear reactor shielding of a type used in reactor applications involving significant amounts of fast neutron flux, the reactor shielding including means providing structural support, neutron moderator material, neutron absorber material and other components as described below, wherein at least a portion of the neutron moderator material is magnesium in the form of magnesium oxide either alone or in combination with other moderator materials such as graphite and iron.

  18. Electric power monthly, September 1990. [Glossary included

    SciTech Connect

    Not Available

    1990-12-17

    The purpose of this report is to provide energy decision makers with accurate and timely information that may be used in forming various perspectives on electric issues. The power plants considered include coal, petroleum, natural gas, hydroelectric, and nuclear power plants. Data are presented for power generation, fuel consumption, fuel receipts and cost, sales of electricity, and unusual occurrences at power plants. Data are compared at the national, Census division, and state levels. 4 figs., 52 tabs. (CK)

  19. Inverse transonic airfoil design including viscous interaction

    NASA Technical Reports Server (NTRS)

    Carlson, L. A.

    1976-01-01

    A numerical technique was developed for the analysis of specified transonic airfoils or for the design of airfoils having a prescribed pressure distribution, including the effect of weak viscous interaction. The method uses the full potential equation, a stretched Cartesian coordinate system, and the Nash-MacDonald turbulent boundary layer method. Comparisons with experimental data for typical transonic airfoils show excellent agreement. An example shows the application of the method to design a thick aft-cambered airfoil, and the effects of viscous interaction on its performance are discussed.

  20. Fuel delivery system including heat exchanger means

    NASA Technical Reports Server (NTRS)

    Coffinberry, G. A. (Inventor)

    1978-01-01

    A fuel delivery system is presented wherein first and second heat exchanger means are each adapted to provide the transfer of heat between the fuel and a second fluid such as lubricating oil associated with the gas turbine engine. Valve means are included which are operative in a first mode to provide for flow of the second fluid through both first and second heat exchange means and further operative in a second mode for bypassing the second fluid around the second heat exchanger means.

  1. View of northeastern Italy including Venice

    NASA Technical Reports Server (NTRS)

    1973-01-01

    A near vertical view of northeastern Italy including the Venice (Venezia) area is seen in this Skylab 3 Earth Resources Experiments Package S190-B (five-inch earth terrain camera) infrared photograph taken from the Skylab space station in Earth orbit. The mountainous area is the Dolomite Alps. The most conspicuous stream northeast of Venice is the Piave River. The city near the center of the picture on the Brenta River is Bassano del Grappa. The large city of Padua (Padova) is on the western bank of the Grenta near the clock.

  2. Ocean management plan includes array of recommendations

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    When U.S. President Bill Clinton and Vice President Al Gore appeared in Monterey, California in June 1998 for a National Oceans Conference, some of the salt water spray from the Pacific Ocean must have clung to them.As a follow-up to the conference, the Clinton Administration on September 2 issued an interagency report to help guide federal efforts in establishing a comprehensive ocean policy.The report, which touches upon a number of global issues including the United Nations Convention on the Law of the Sea, contains nearly 150 recommendations.

  3. Including supplementary elements in a compositional biplot

    NASA Astrophysics Data System (ADS)

    Daunis-i-Estadella, J.; Thió-Henestrosa, S.; Mateu-Figueras, G.

    2011-05-01

    The biplot is a widely and powerful methodology used with multidimensional data sets to describe and display the relationships between observations and variables in an easy way. Compositional data are vectors with positive components, whose sum is constant because they represent a relative contribution of different parts to a whole; due to this property standard biplots cannot be performed with compositional data, instead of a previous transformation of the data is performed. In this paper, we extend the compositional biplot defined by Aitchison and Greenacre (2002), in order to include in the display supplementary elements which are not used in the definition of the compositional biplot. Different types of supplementary elements are considered: supplementary parts of the composition, supplementary continuous variables external to the composition, supplementary categorical variables and supplementary observations. The projection of supplementary parts of the composition is done by means of the equivalence of clr and lr biplots. The other supplementary projections are done by classical methodology. An application example with a real geological data is included.

  4. Aerosol simulation including chemical and nuclear reactions

    SciTech Connect

    Marwil, E.S.; Lemmon, E.C.

    1985-01-01

    The numerical simulation of aerosol transport, including the effects of chemical and nuclear reactions presents a challenging dynamic accounting problem. Particles of different sizes agglomerate and settle out due to various mechanisms, such as diffusion, diffusiophoresis, thermophoresis, gravitational settling, turbulent acceleration, and centrifugal acceleration. Particles also change size, due to the condensation and evaporation of materials on the particle. Heterogeneous chemical reactions occur at the interface between a particle and the suspending medium, or a surface and the gas in the aerosol. Homogeneous chemical reactions occur within the aersol suspending medium, within a particle, and on a surface. These reactions may include a phase change. Nuclear reactions occur in all locations. These spontaneous transmutations from one element form to another occur at greatly varying rates and may result in phase or chemical changes which complicate the accounting process. This paper presents an approach for inclusion of these effects on the transport of aerosols. The accounting system is very complex and results in a large set of stiff ordinary differential equations (ODEs). The techniques for numerical solution of these ODEs require special attention to achieve their solution in an efficient and affordable manner. 4 refs.

  5. Should family planning include STD services?

    PubMed

    Finger, W R

    1994-05-01

    Recent reviews suggest that the addition of programs aimed at preventing and controlling sexually transmitted diseases (STDs), specifically human immunodeficiency virus (HIV), to existing family planning programs does not necessarily dilute overall program effectiveness. In Colombia, Mexico, and Jamaica, where condom distribution and/or information to prevent HIV transmission was integrated into the activities of family planning field workers, no negative effect on the image of condoms as a pregnancy prevention method was observed and there was a great demand on the part of family planning clients for information about acquired immunodeficiency syndrome (AIDS). In Brazil, family planning staff are receiving training in HIV risk assessment and the counseling of women in partner negotiation skills. However, steps must be taken to reach men since it is their high-risk behavior that puts most women at risk of HIV. Both separate STD clinics for men and condom social marketing projects have yielded promising results. Obstacles to the addition of STD services to family planning programs include the need to treat male partners as well as female clients, a shortage of diagnostic tools and antibiotics for treatment, and the fact that the majority of women with STDs are asymptomatic. Indicative of the increased attention being given this approach, however, is the recent release of guidelines by the US Agency for International Development Office of Population on how family planning programs should approach integration. Suggested activities include condom promotion, behavior change, counseling, information, contraceptive development, and selected efforts at STD treatment.

  6. Treatment for pulmonary hypertension including lung transplantation.

    PubMed

    Kusano, Kengo F

    2011-08-01

    Pulmonary hypertension (PH) is a progressive disease characterized by sustained elevation in pulmonary arterial pressure and increased pulmonary vascular resistance, leading to right-sided ventricular failure. The untreated median survival period is 2-3 years from the time of diagnosis, with the cause of death usually being right-sided ventricular failure. However, outcomes have dramatically changed in recent years because of great advances in medical management of PH, including early diagnosis and new drugs such as prostaglandins, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors. Long-term continuous intravenous prostacyclin therapy has shown excellent results in patients with PH. More recently, a molecular-targeted agent, imatinib mesylate, that acts by specifically inhibiting a certain enzyme that is characteristic of a particular cancer cell, rather than nonspecifically inhibiting and killing all rapidly dividing cells, has also been shown to have a potential role in the treatment of PH. This drug has been shown to reduce both pulmonary arterial smooth muscle cell hypertrophy and hyperplasia in a variety of disease processes. We summarize here recent topics regarding PH and advances in treatments for PH, particularly pulmonary arterial hypertension, including lung transplantation.

  7. Simple model of membrane proteins including solvent.

    PubMed

    Pagan, D L; Shiryayev, A; Connor, T P; Gunton, J D

    2006-05-14

    We report a numerical simulation for the phase diagram of a simple two-dimensional model, similar to the one proposed by Noro and Frenkel [J. Chem. Phys. 114, 2477 (2001)] for membrane proteins, but one that includes the role of the solvent. We first use Gibbs ensemble Monte Carlo simulations to determine the phase behavior of particles interacting via a square-well potential in two dimensions for various values of the interaction range. A phenomenological model for the solute-solvent interactions is then studied to understand how the fluid-fluid coexistence curve is modified by solute-solvent interactions. It is shown that such a model can yield systems with liquid-liquid phase separation curves that have both upper and lower critical points, as well as closed loop phase diagrams, as is the case with the corresponding three-dimensional model.

  8. Including eddies in global ocean models

    NASA Astrophysics Data System (ADS)

    Semtner, Albert J.; Chervin, Robert M.

    The ocean is a turbulent fluid that is driven by winds and by surface exchanges of heat and moisture. It is as important as the atmosphere in governing climate through heat distribution, but so little is known about the ocean that it remains a “final frontier” on the face of the Earth. Many ocean currents are truly global in extent, such as the Antarctic Circumpolar Current and the “conveyor belt” that connects the North Atlantic and North Pacific oceans by flows around the southern tips of Africa and South America. It has long been a dream of some oceanographers to supplement the very limited observational knowledge by reconstructing the currents of the world ocean from the first principles of physics on a computer. However, until very recently, the prospect of doing this was thwarted by the fact that fluctuating currents known as “mesoscale eddies” could not be explicitly included in the calculation.

  9. DEVELOPMENT OF WATER CIRCULATION MODEL INCLUDING IRRIGATION

    NASA Astrophysics Data System (ADS)

    Kotsuki, Shunji; Tanaka, Kenji; Kojiri, Toshiharu; Hamaguchi, Toshio

    It is well known that since agricultural water withdrawal has much affect on water circulation system, accurate analysis of river discharge or water balance are difficult with less regard for it. In this study, water circulation model composed of land surface model and distributed runoff model is proposed at 10km 10km resolution. In this model, irrigation water, which is estimated with land surface model, is introduced to river discharge analysis. The model is applied to the Chao Phraya River in Thailand, and reproduced seasonal water balance. Additionally, the discharge on dry season simulated with the model is improved as a result of including irrigation. Since the model, which is basically developed from global data sets, simulated seasonal change of river discharge, it can be suggested that our model has university to other river basins.

  10. Eigenstates of Moebius nanostructures including curvature effects

    SciTech Connect

    Gravesen, J.; Willatzen, M.

    2005-09-15

    Moebius-shell structures and their physical properties have recently received considerable attention experimentally and theoretically. In this work, eigenstates and associated eigenenergies are determined for a quantum-mechanical particle bounded to a Moebius shell including curvature contributions to the kinetic-energy operator. This is done using a parametrization of the Moebius shell-found by minimizing the elastic energy of the full structure-and employing differential-geometry methods. It is shown that inclusion of curvature contributions to the kinetic energy leads to splitting of the otherwise doubly degenerate groundstate and significantly alters the form of the groundstate and excited-state wavefunctions. Hence, we anticipate qualitative changes in the physical properties of Moebius-shell structures due to surface confinement and curvature effects.

  11. Education Program on Fossil Resources Including Coal

    NASA Astrophysics Data System (ADS)

    Usami, Masahiro

    Fossil fuels including coal play a key role as crucial energies in contributing to economic development in Asia. On the other hand, its limited quantity and the environmental problems causing from its usage have become a serious global issue and a countermeasure to solve such problems is very much demanded. Along with the pursuit of sustainable development, environmentally-friendly use of highly efficient fossil resources should be therefore, accompanied. Kyushu-university‧s sophisticated research through long years of accumulated experience on the fossil resources and environmental sectors together with the advanced large-scale commercial and empirical equipments will enable us to foster cooperative research and provide internship program for the future researchers. Then, this program is executed as a consignment business from the Ministry of Economy, Trade and Industry from 2007 fiscal year to 2009 fiscal year. The lecture that uses the textbooks developed by this program is scheduled to be started a course in fiscal year 2010.

  12. Thermovoltaic semiconductor device including a plasma filter

    DOEpatents

    Baldasaro, Paul F.

    1999-01-01

    A thermovoltaic energy conversion device and related method for converting thermal energy into an electrical potential. An interference filter is provided on a semiconductor thermovoltaic cell to pre-filter black body radiation. The semiconductor thermovoltaic cell includes a P/N junction supported on a substrate which converts incident thermal energy below the semiconductor junction band gap into electrical potential. The semiconductor substrate is doped to provide a plasma filter which reflects back energy having a wavelength which is above the band gap and which is ineffectively filtered by the interference filter, through the P/N junction to the source of radiation thereby avoiding parasitic absorption of the unusable portion of the thermal radiation energy.

  13. Optical panel system including stackable waveguides

    DOEpatents

    DeSanto, Leonard; Veligdan, James T.

    2007-11-20

    An optical panel system including stackable waveguides is provided. The optical panel system displays a projected light image and comprises a plurality of planar optical waveguides in a stacked state. The optical panel system further comprises a support system that aligns and supports the waveguides in the stacked state. In one embodiment, the support system comprises at least one rod, wherein each waveguide contains at least one hole, and wherein each rod is positioned through a corresponding hole in each waveguide. In another embodiment, the support system comprises at least two opposing edge structures having the waveguides positioned therebetween, wherein each opposing edge structure contains a mating surface, wherein opposite edges of each waveguide contain mating surfaces which are complementary to the mating surfaces of the opposing edge structures, and wherein each mating surface of the opposing edge structures engages a corresponding complementary mating surface of the opposite edges of each waveguide.

  14. Optical panel system including stackable waveguides

    DOEpatents

    DeSanto, Leonard; Veligdan, James T.

    2007-03-06

    An optical panel system including stackable waveguides is provided. The optical panel system displays a projected light image and comprises a plurality of planar optical waveguides in a stacked state. The optical panel system further comprises a support system that aligns and supports the waveguides in the stacked state. In one embodiment, the support system comprises at least one rod, wherein each waveguide contains at least one hole, and wherein each rod is positioned through a corresponding hole in each waveguide. In another embodiment, the support system comprises at least two opposing edge structures having the waveguides positioned therebetween, wherein each opposing edge structure contains a mating surface, wherein opposite edges of each waveguide contain mating surfaces which are complementary to the mating surfaces of the opposing edge structures, and wherein each mating surface of the opposing edge structures engages a corresponding complementary mating surface of the opposite edges of each waveguide.

  15. Drapery assembly including insulated drapery liner

    DOEpatents

    Cukierski, Gwendolyn

    1983-01-01

    A drapery assembly is disclosed for covering a framed wall opening, the assembly including drapery panels hung on a horizontal traverse rod, the rod having a pair of master slides and means for displacing the master slides between open and closed positions. A pair of insulating liner panels are positioned behind the drapery, the remote side edges of the liner panels being connected with the side portions of the opening frame, and the adjacent side edges of the liner panels being connected with a pair of vertically arranged center support members adapted for sliding movement longitudinally of a horizontal track member secured to the upper horizontal portion of the opening frame. Pivotally arranged brackets connect the center support members with the master slides of the traverse rod whereby movement of the master slides to effect opening and closing of the drapery panels effects simultaneous opening and closing of the liner panels.

  16. Imaging of axial spondyloarthritis including ankylosing spondylitis.

    PubMed

    Braun, J; Baraliakos, X

    2011-03-01

    New bone formation of the vertebral column is pathognomonic for ankylosing spondylitis (AS), while acute and/or chronic changes in the sacroiliac joints are relevant for diagnosis. The 'gold standard' for assessment of structural changes in AS are conventional radiographs, while MRI is useful to assess inflammation. Recent MRI studies have shown that the lower half of the thoracic spine is most commonly affected in AS. Scoring tools for spinal inflammation such as the ASspiMRI-a have been proposed, successfully used in large clinical trials and compared in a multireader experiment; none was finally preferred by OMERACT. Quantification of structural spinal AS changes is performed by the modified Stokes AS Spine Score (mSASSS), which evaluates lateral cervical and lumbar radiographs. Two years was identified as the shortest possible follow-up time based on the reliability and sensitivity to change of the mSASSS. A potential disadvantage of the mSASSS is that the thoracic spine is not included. Recent data based on the mSASSS have suggested that tumour necrosis factor blockers do not inhibit radiographic progression in AS. Since the mean radiographic change is reported to be less than 1 syndesmophyte over 2 years, the sensitivity to change of the mSASSS has been questioned. However, in one study where continuous non-steroidal anti-inflammatory drugs use was compared with on-demand use, a difference between these two methods of drug intake was reported. The face and construct validity of the mSASSS has been criticised because a score of ´1´ contains a mixture of osteodestructive (erosions) and osteoproliferative changes (squaring and sclerosis). A new scoring system, the RASSS, which concentrates only on bone formation and which includes the lower part of the thoracic spine is currently being evaluated. The relationship between inflammation and new bone formation in AS has recently been investigated. Low sclerostin and DKK-1 serum levels, both inhibitors of bone

  17. Analysis of Smart Composite Structures Including Debonding

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Aditi; Seeley, Charles E.

    1997-01-01

    Smart composite structures with distributed sensors and actuators have the capability to actively respond to a changing environment while offering significant weight savings and additional passive controllability through ply tailoring. Piezoelectric sensing and actuation of composite laminates is the most promising concept due to the static and dynamic control capabilities. Essential to the implementation of these smart composites are the development of accurate and efficient modeling techniques and experimental validation. This research addresses each of these important topics. A refined higher order theory is developed to model composite structures with surface bonded or embedded piezoelectric transducers. These transducers are used as both sensors and actuators for closed loop control. The theory accurately captures the transverse shear deformation through the thickness of the smart composite laminate while satisfying stress free boundary conditions on the free surfaces. The theory is extended to include the effect of debonding at the actuator-laminate interface. The developed analytical model is implemented using the finite element method utilizing an induced strain approach for computational efficiency. This allows general laminate geometries and boundary conditions to be analyzed. The state space control equations are developed to allow flexibility in the design of the control system. Circuit concepts are also discussed. Static and dynamic results of smart composite structures, obtained using the higher order theory, are correlated with available analytical data. Comparisons, including debonded laminates, are also made with a general purpose finite element code and available experimental data. Overall, very good agreement is observed. Convergence of the finite element implementation of the higher order theory is shown with exact solutions. Additional results demonstrate the utility of the developed theory to study piezoelectric actuation of composite

  18. Reconsidering remineralization strategies to include nanoparticle hydroxyapatite.

    PubMed

    Kutsch, V Kim; Chaiyabutr, Yada; Milicich, Graeme

    2013-03-01

    Dental caries is a transmissible biofilm-mediated disease of the teeth that is defined by prolonged periods of low pH resulting in net mineral loss from the teeth. Hydroxyapatite, fluorapatite, and the carbonated forms of calcium phosphate form the main mineral content of dental hard tissues: enamel, dentin, and cementum. Active dental caries results when the biofilm pH on the tooth surface drops below the dissolution threshold for hydroxyapatite and fluorapatite. The clinical evidence of this net mineral loss is porosity, whitespot lesions, caries lesions, and/or cavitation. The potential to reverse this mineral loss through remineralization has been well documented, although previous remineralization strategies for dental hard tissues have focused on the use of fluorides and forms of calcium phosphate. This in-vitro study documented the deposition of nanoparticle hydroxyapatite on demineralized enamel surfaces after treatment with an experimental remineralization gel. This finding supports consideration of an additional approach to remineralization that includes pH neutralization strategies and nanoparticle hydroxyapatite crystals.

  19. Engine lubrication circuit including two pumps

    DOEpatents

    Lane, William H.

    2006-10-03

    A lubrication pump coupled to the engine is sized such that the it can supply the engine with a predetermined flow volume as soon as the engine reaches a peak torque engine speed. In engines that operate predominately at speeds above the peak torque engine speed, the lubrication pump is often producing lubrication fluid in excess of the predetermined flow volume that is bypassed back to a lubrication fluid source. This arguably results in wasted power. In order to more efficiently lubricate an engine, a lubrication circuit includes a lubrication pump and a variable delivery pump. The lubrication pump is operably coupled to the engine, and the variable delivery pump is in communication with a pump output controller that is operable to vary a lubrication fluid output from the variable delivery pump as a function of at least one of engine speed and lubrication flow volume or system pressure. Thus, the lubrication pump can be sized to produce the predetermined flow volume at a speed range at which the engine predominately operates while the variable delivery pump can supplement lubrication fluid delivery from the lubrication pump at engine speeds below the predominant engine speed range.

  20. [Contracts including performance and management of uncertainty].

    PubMed

    Duru, G; Garassus, P; Auray, J-P

    2013-09-01

    Since many decades in France, the most important part of ambulatory health care expenditure is represented by drug consumption. By the fact, French patient is indeed the greatest world consumer of pharmaceuticals treatments. Therefore, the regulation authorities by successive strategies, attempt to limit or even restrict market access for new drugs in the health care sector secured by public social insurance coverage. Common objectives are to assess the reimbursement to scientific studies and to fix the price of therapeutics at an acceptable level for both industries and government. New trends try then to determine recently the drug price in a dual approach, as a component of global and effective contract, including performance and outcome. The first diffusion authorization is diffusion concerned, but this concept takes into account the eventual success of new produces in long-term survey. Signed for a fixed period as reciprocal partnership between regulation authorities and pharmaceutics industries, the contract integrates two dimensions of incertitude. The first one is represented by the strategy of new treatments development according to efficacy and adapted price, and the second one is linked to the result of diffusion and determines adapted rules if eventual non-respects of the previous engagement are registered. This paper discusses problems related to this new dimension of incertitude affected by conditional drug prices in market access strategy and the adapted follow-up of new treatment diffusion fixed by "outcome" contract between French regulation administration and pharmaceutics industries in our recent economic context.

  1. Articles including thin film monolayers and multilayers

    DOEpatents

    Li, DeQuan; Swanson, Basil I.

    1995-01-01

    Articles of manufacture including: (a) a base substrate having an oxide surface layer, and a multidentate ligand, capable of binding a metal ion, attached to the oxide surface layer of the base substrate, (b) a base substrate having an oxide surface layer, a multidentate ligand, capable of binding a metal ion, attached to the oxide surface layer of the base substrate, and a metal species attached to the multidentate ligand, (c) a base substrate having an oxide surface layer, a multidentate ligand, capable of binding a metal ion, attached to the oxide surface layer of the base substrate, a metal species attached to the multidentate ligand, and a multifunctional organic ligand attached to the metal species, and (d) a base substrate having an oxide surface layer, a multidentate ligand, capable of binding a metal ion, attached to the oxide surface layer of the base substrate, a metal species attached to the multidentate ligand, a multifunctional organic ligand attached to the metal species, and a second metal species attached to the multifunctional organic ligand, are provided, such articles useful in detecting the presence of a selected target species, as nonliear optical materials, or as scavengers for selected target species.

  2. Extending Newtonian Dynamics to Include Stochastic Processes

    NASA Technical Reports Server (NTRS)

    Zak, Michail

    2009-01-01

    A paper presents further results of continuing research reported in several previous NASA Tech Briefs articles, the two most recent being Stochastic Representations of Chaos Using Terminal Attractors (NPO-41519), [Vol. 30, No. 5 (May 2006), page 57] and Physical Principle for Generation of Randomness (NPO-43822) [Vol. 33, No. 5 (May 2009), page 56]. This research focuses upon a mathematical formalism for describing post-instability motions of a dynamical system characterized by exponential divergences of trajectories leading to chaos (including turbulence as a form of chaos). The formalism involves fictitious control forces that couple the equations of motion of the system with a Liouville equation that describes the evolution of the probability density of errors in initial conditions. These stabilizing forces create a powerful terminal attractor in probability space that corresponds to occurrence of a target trajectory with probability one. The effect in configuration space (ordinary three-dimensional space as commonly perceived) is to suppress exponential divergences of neighboring trajectories without affecting the target trajectory. As a result, the post-instability motion is represented by a set of functions describing the evolution of such statistical quantities as expectations and higher moments, and this representation is stable.

  3. Design philosophy for reliable systems, including control

    SciTech Connect

    Gabriel, J.R.

    1984-04-01

    In the past, use of computers and software to manage physical plant has usually involved systems similar to the clockwork automata of the 17th century. The next generation of plant control will include intelligent systems - computer systems having knowledge of the plant and being capable of intelligent behavior, even though only some control functions will need such expertise. This report develops a framework for a universe of discourse usable by such non-human experts. It is based on the idea that a design has many features of a contract and may be described as a contract between humans and a machine, defining what each must do to attain a goal. Several points are discussed: the use of techniques in analytical redundancy and their place as analogues in administrative control for conventional techniques in physical control; the use of redundant computer systems to protect against hardware faults; the necessity to prove properties of software used in redundant hardware, because software faults are common modes across redundant hardware; and some issues in choosing a programming language for provable control software. Because proof of correctness is costly, it should be used only where necessary. This report concludes that the degree of reliability needed by the plant model used in analytic redundancy protection need not be nearly as reliable as the mechanism to detect discrepancy between plant and model.

  4. Optical design including characteristics of manufactured nanostructures

    NASA Astrophysics Data System (ADS)

    Wächter, Christoph; Müller, Martin; Förster, Erik; Oliva, Maria; Michaelis, Dirk

    2013-09-01

    Micro- and nanostructures enable specific optical functionalities, which rely on diffractive effects or effective medium features, depending on pattern dimension and wavelength. Performance predictions of optical systems which make use of nanostructured materials require having an accurate description of these materials ready to hand within the optical design. At the one hand, nanostructure characteristics which result from rigorous electromagnetic modeling can be used for the optical design. At the other hand, manufactured nanostructures may deviate from their idealized geometry, which will affect the performance of the optical system, wherein these artificial structures will be used. Thus, detailed optical characterization of the micro- or nanostructure functionality is prerequisite for accurate optical design and performance prediction. To this end, several characterization techniques can be applied depending on the scope of the optical design, finally. We report on a general route to include all accessible and required optical information about the nanostructured material within a corresponding model of the nanostructure as a specific optical component which can be used within a ray-trace engine, finally. This is illustrated by a meta-material with asymmetric transmission properties in some more detail.

  5. Including lifestyle medicine in undergraduate medical curricula

    PubMed Central

    Phillips, Edward; Pojednic, Rachele; Polak, Rani; Bush, Jennifer; Trilk, Jennifer

    2015-01-01

    Purpose Currently, there is no model to integrate the discipline of lifestyle medicine (LM) into undergraduate medical education. Furthermore, there are no guidelines, validated assessment tools, or evaluation or implementation plans in place. Background The World Health Organization predicts that by 2020, two-thirds of disease worldwide will be the result of poor lifestyle choices. Fewer than 50% of US primary care physicians routinely provide specific guidance on nutrition, physical activity, or weight control. Methods We are establishing a plan to integrate LM into medical school education in collaboration with the investing stakeholders, including medical school deans and students, medical curriculum developers and researchers, medical societies, governing bodies, and policy institutes. Three planning and strategy meetings are being held to address key areas of focus – with a particular interest in nutrition, physical activity, student self-care, and behavior change – to develop specific implementation guidelines and landmarks. Results After the first two meetings, the proposed areas of focus were determined to be: 1) supporting of deans and key personnel, 2) creation of federal and state policy commitments, 3) use of assessment as a driver of LM, 4) provision of high-quality evidence-based curricular material on an easily navigated site, and 5) engaging student interest. Implementation strategies for each focus area will be addressed in an upcoming planning meeting in early 2015. Conclusion This initiative is expected to have important public health implications by efficiently promoting the prevention and treatment of non-communicable chronic disease with a scalable and sustainable model to educate physicians in training and practice. PMID:25652118

  6. Including Tidal Effects in Tsunami Forecasting

    NASA Astrophysics Data System (ADS)

    Arcas, D.

    2015-12-01

    Recently a new tsunami forecast system SIFT (Short-term Inundation and Forecasting of Tsunamis) has been declared operational by the National Weather Service (NWS) Tsunami Warning Centers. The SIFT system assimilates real-time information from a network of observing systems deployed in the open ocean, to produce on-the-fly estimates of tsunami impact at specific coastal communities. These estimates are computed via the tsunami simulation code MOST (Method of Splitting Tsunami) and include forecast products such as tsunami arrival time, duration of the event, predicted tsunami currents, maximum sea surface elevation and expected inundation areas. These computations are performed under the assumption that the mean sea level remains constant at Mean High Water (MHW) during the entire tsunami event. This assumption produces conservative tsunami forecasts that tend to err on the side of caution with the possibility of substantial overestimates of the inundation areas. To avoid this problem and produce more accurate, operational tsunami forecasts, we investigate the effects of tsunami interaction with tides. The nonlinear dynamic interaction is simulated by first, simulating tidal elevations and currents with Oregon State University tidal model, to obtain boundary and initial conditions to force the MOST tsunami model. Tsunami boundary and initial conditions can be added to those for the tide to study the combined effect. Our results show that even at locations with strong tidal forcing, the tsunami/tide interaction effect has a weakly non-linear effect on the tsunami elevation waveform. This interaction, however, will have a significant effect on the extent of the inundation area. Based on these findings we propose a simple, linear correction to the standard MHW forecast for tsunami time series and inundation area, that can be performed on-the-fly by the SIFT system without the need for complex tidal models.

  7. Compact Radar Transceiver with Included Calibration

    NASA Technical Reports Server (NTRS)

    McLinden, Matthew; Rincon, Rafael

    2013-01-01

    The Digital Beamforming Synthetic Aperture Radar (DBSAR) is an eight-channel phased array radar system that employs solid-state radar transceivers, a microstrip patch antenna, and a reconfigurable waveform generator and processor unit. The original DBSAR transceiver design utilizes connectorized electronic components that tend to be physically large and heavy. To achieve increased functionality in a smaller volume, PCB (printed circuit board) transceivers were designed to replace the large connectorized transceivers. One of the most challenging problems designing the transceivers in a PCB format was achieving proper performance in the calibration path. For a radar loop-back calibration path, a portion of the transmit signal is coupled out of the antenna feed and fed back into the receiver. This is achieved using passive components for stability and repeatability. Some signal also leaks through the receive path. As these two signal paths are correlated via an unpredictable phase, the leakage through the receive path during transmit must be 30 dB below the calibration path. For DBSAR s design, this requirement called for a 100-dB isolation in the receiver path during transmit. A total of 16 solid-state L-band transceivers on a PCB format were designed. The transceivers include frequency conversion stages, T/R switching, and a calibration path capable of measuring the transmit power-receiver gain product during transmit for pulse-by-pulse calibration or matched filtering. In particular, this calibration path achieves 100-dB isolation between the transmitted signal and the low-noise amplifier through the use of a switching network and a section of physical walls achieving attenuation of radiated leakage. The transceivers were designed in microstrip PCBs with lumped elements and individually packaged components for compactness. Each transceiver was designed on a single PCB with a custom enclosure providing interior walls and compartments to isolate transceiver

  8. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    NASA Astrophysics Data System (ADS)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    The dilemma of designing an advanced undergraduate laboratory lies in the desire to teach and reinforce basic principles and techniques while at the same time exposing students to the excitement of research. We report here on a one-semester, project-based biochemistry laboratory that combines the best features of a cookbook approach (high success rate, achievement of defined goals) with those of an investigative, discovery-based approach (student involvement in the experimental design, excitement of real research). Individual modules may be selected and combined to meet the needs of different courses and different institutions. The central theme of this lab is protein purification and design. This laboratory accompanies the first semester of biochemistry (Structure and Function of Macromolecules, a course taken mainly by junior and senior chemistry and biological chemistry majors). The protein chosen as the object of study is the enzyme lysozyme, which is utilized in all projects. It is suitable for a student lab because it is easily and inexpensively obtained from egg white and is extremely stable, and its high isoelectric point (pI = 11) allows for efficient separation from other proteins by ion-exchange chromatography. Furthermore, a literature search conducted by the resourceful student reveals a wealth of information, since lysozyme has been the subject of numerous studies. It was the first enzyme whose structure was determined by crystallography (1). Hendrickson et al. (2) have previously described an intensive one-month laboratory course centered around lysozyme, although their emphasis is on protein stability rather than purification and engineering. Lysozyme continues to be the focus of much exciting new work on protein folding and dynamics, structure and activity (3 - 5). This lab course includes the following features: (i) reinforcement of basic techniques, such as preparation of buffers, simple enzyme kinetics, and absorption spectroscopy; (ii

  9. 76 FR 35026 - Hutchinson Technology, Inc., Including On-Site Workers Leased From Doherty, Including Workers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Doherty, Including Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Aramark Business..., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Aramark Business Facilities, LLC... wages reported under a separate unemployment insurance (UI) tax account under the name Aramark...

  10. Promoting Social Inclusion Counting with Everyone: Learning Communities and INCLUD-ED

    ERIC Educational Resources Information Center

    Gatt, Suzanne; Ojala, Mikko; Soler, Marta

    2011-01-01

    The scientific community has provided a wide range of evidence that family and community involvement in schools benefits not only students' learning but also their surrounding community. The INCLUD-ED project has conducted case studies of successful schools around Europe that have strong community participation. Some of them are engaged in the…

  11. Ionic liquids, electrolyte solutions including the ionic liquids, and energy storage devices including the ionic liquids

    SciTech Connect

    Gering, Kevin L.; Harrup, Mason K.; Rollins, Harry W.

    2015-12-08

    An ionic liquid including a phosphazene compound that has a plurality of phosphorus-nitrogen units and at least one pendant group bonded to each phosphorus atom of the plurality of phosphorus-nitrogen units. One pendant group of the at least one pendant group comprises a positively charged pendant group. Additional embodiments of ionic liquids are disclosed, as are electrolyte solutions and energy storage devices including the embodiments of the ionic liquid.

  12. Launch Lock Assemblies Including Axial Gap Amplification Devices and Spacecraft Isolation Systems Including the Same

    NASA Technical Reports Server (NTRS)

    Barber, Tim Daniel (Inventor); Hindle, Timothy (Inventor); Young, Ken (Inventor); Davis, Torey (Inventor)

    2014-01-01

    Embodiments of a launch lock assembly are provided, as are embodiments of a spacecraft isolation system including one or more launch lock assemblies. In one embodiment, the launch lock assembly includes first and second mount pieces, a releasable clamp device, and an axial gap amplification device. The releasable clamp device normally maintains the first and second mount pieces in clamped engagement; and, when actuated, releases the first and second mount pieces from clamped engagement to allow relative axial motion there between. The axial gap amplification device normally residing in a blocking position wherein the gap amplification device obstructs relative axial motion between the first and second mount pieces. The axial gap amplification device moves into a non-blocking position when the first and second mount pieces are released from clamped engagement to increase the range of axial motion between the first and second mount pieces.

  13. Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation.

    PubMed

    Im, Ji-Hyun; Jin, Yong-Ri; Lee, Jung-Jin; Yu, Ji-Yeon; Han, Xiang-Hua; Im, Se-Hyuk; Hong, Jin Tae; Yoo, Hwan-Soo; Pyo, Myoung-Yun; Yun, Yeo-Pyo

    2009-01-01

    Beta-carboline alkaloids including harmalol, harmaline, norharmane, harmol, harmine and harmane are important constituents of the medicinal plant, Perganum harmala L. (Zygophylaceae), which has been used in traditional medicine. In the present study, the antiplatelet activities of six beta-carboline alkaloid compounds were investigated in vitro. At a concentration of 200 microM, these compounds have no effect on arachidonic acid (AA)-, thrombin- and U46619 (a thromboxane A2 mimic)-stimulated platelet aggregation. On the contrary, it was revealed that collagen-induced platelet aggregation could be inhibited by these compounds with different potencies (harmane and harmine were most potent, harmol had medium potency, and harmol, norharmane, harmalol and harmaline had a weak, non significant effect), indicating a selective inhibition on collagen-mediated platelet activation. Consistently, further study revealed that collagen-mediated phospholipase (PL) Cgamma2 and protein tyrosine phosphorylation, cytosolic calcium mobilization and arachidonic acid liberation were completely inhibited by harmane and harmine in a concentration-dependent manner, while the other compounds were only partially or not effective at all. Taken together, these results indicate that three of these six beta-carboline alkaloids can selectively affect collagen-induced platelet aggregation with different potencies; in particular, harmane and harmine were most potent, and their antiplatelet activities may be mediated by inhibiting PLCgamma2 and protein tyrosine phosphorylation with sequential suppression of cytosolic calcium mobilization and arachidonic acid liberation, indicating that harmane and harmine have a potential to be developed as a novel agent for atherothrombotic diseases.

  14. 25 CFR 20.309 - What does unearned income include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... include? Unearned income includes, but is not limited to: (a) Income from interest; oil and gas and other... statute; (d) Income from sale of trust land and real or personal property that is set aside...

  15. Haemophilus influenzae Disease (Including Hib) Diagnosis and Treatment

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Haemophilus influenzae Disease (Including Hib) Note: Javascript is disabled or ... Compartir On this Page Diagnosis Treatment Complications Diagnosis Haemophilus influenzae , including Hib, disease is usually diagnosed with one ...

  16. Should Relational Aggression Be Included in DSM-V?

    ERIC Educational Resources Information Center

    Keenan, Kate; Coyne, Claire; Lahey, Benjamin B.

    2008-01-01

    The study examines whether relational aggression should be included in DSM-V disruptive behavior disorders. The results conclude that some additional information is gathered from assessing relational aggression but not enough to be included in DSM-V.

  17. Including Alternate Assessment Results in Accountability Decisions. NCEO Policy Directions.

    ERIC Educational Resources Information Center

    Quenemoen, Rachel; Thurlow, Martha

    Alternate assessments provide a mechanism for students with complex disabilities to be included in assessment systems. An integral part of maximizing the benefits of assessing students is to include the results of alternate assessments in school accountability systems. This report addresses policy options for including the results of alternate…

  18. 29 CFR 780.616 - Operations included in raising livestock.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Operations included in raising livestock. 780.616 Section... Employment in Agriculture and Livestock Auction Operations Under the Section 13(b)(13) Exemption Requirements for Exemption § 780.616 Operations included in raising livestock. Raising livestock includes...

  19. 20 CFR 220.114 - Evaluation of symptoms, including pain.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Evaluation of symptoms, including pain. 220... RETIREMENT ACT DETERMINING DISABILITY Medical Considerations § 220.114 Evaluation of symptoms, including pain...'s symptoms, including pain, and the extent to which the claimant's symptoms can reasonably...

  20. 20 CFR 220.114 - Evaluation of symptoms, including pain.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evaluation of symptoms, including pain. 220... RETIREMENT ACT DETERMINING DISABILITY Medical Considerations § 220.114 Evaluation of symptoms, including pain...'s symptoms, including pain, and the extent to which the claimant's symptoms can reasonably...

  1. 20 CFR 220.114 - Evaluation of symptoms, including pain.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Evaluation of symptoms, including pain. 220... RETIREMENT ACT DETERMINING DISABILITY Medical Considerations § 220.114 Evaluation of symptoms, including pain...'s symptoms, including pain, and the extent to which the claimant's symptoms can reasonably...

  2. 20 CFR 220.114 - Evaluation of symptoms, including pain.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Evaluation of symptoms, including pain. 220... RETIREMENT ACT DETERMINING DISABILITY Medical Considerations § 220.114 Evaluation of symptoms, including pain...'s symptoms, including pain, and the extent to which the claimant's symptoms can reasonably...

  3. 20 CFR 220.114 - Evaluation of symptoms, including pain.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Evaluation of symptoms, including pain. 220... RETIREMENT ACT DETERMINING DISABILITY Medical Considerations § 220.114 Evaluation of symptoms, including pain...'s symptoms, including pain, and the extent to which the claimant's symptoms can reasonably...

  4. 26 CFR 1.1013-1 - Property included in inventory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Property included in inventory. 1.1013-1... included in inventory. The basis of property required to be included in inventory is the last inventory... an inventory are stated in subpart D (section 471 and following), part II, subchapter E, chapter 1...

  5. Looking Northwest at Office Building Boiler Room, Including Cinderblock Walls, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking Northwest at Office Building Boiler Room, Including Cinderblock Walls, Fuel Tank and Scale Weights - Hematite Fuel Fabrication Facility, Office, 3300 State Road P, Festus, Jefferson County, MO

  6. WEST (FRONT) OF FURNACE COMPLEX, INCLUDING STACKS, WITH CHARGING BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST (FRONT) OF FURNACE COMPLEX, INCLUDING STACKS, WITH CHARGING BRIDGE AND TRESSLE, LOOKING SOUTHEAST. - Tannehill Furnace, 12632 Confederate Parkway, Tannehill Historical State Park, Bucksville, Tuscaloosa County, AL

  7. 21. DETAIL VIEW OF MARSICAL WORKS CONDENSERS INCLUDING QUICKSILVER COLLECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. DETAIL VIEW OF MARSICAL WORKS CONDENSERS INCLUDING QUICKSILVER COLLECTION CHANNEL AND COLLECTION BOX, CENTER FOREGROUND, LOOKING SOUTH, SOUTHEAST. - Mariscal Quicksilver Mine & Reduction Works, Terlingua, Brewster County, TX

  8. 10. PHOTOCOPY OF 1875 WOODCUT OF THE BRIDGE INCLUDING THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. PHOTOCOPY OF 1875 WOODCUT OF THE BRIDGE INCLUDING THE MANUFACTURERS ADVERTISING - Callowhill Street Bridge, Schuylkill River at Spring Garden & Callowhill Streets, Philadelphia, Philadelphia County, PA

  9. DETAIL VIEW OF MARISCAL WORKS CONDENSERS INCLUDING QUICKSILVER COLLECTION CHANNEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF MARISCAL WORKS CONDENSERS INCLUDING QUICKSILVER COLLECTION CHANNEL AND COLLECTION BOX, CENTER FOREGROUND, LOOKING SOUTH, SOUTHEAST. - Mariscal Quicksilver Mine & Reduction Works, Terlingua, Brewster County, TX

  10. VIEW OF MARISCAL WORKS INCLUDING (POSSIBLE SOOT FURNACE), FOREGROUND, CONDENSERS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF MARISCAL WORKS INCLUDING (POSSIBLE SOOT FURNACE), FOREGROUND, CONDENSERS AND ORE BIN FOUNDATION ABOVE, LOOKING NORTHWEST. - Mariscal Quicksilver Mine & Reduction Works, Terlingua, Brewster County, TX

  11. 18. VIEW OF MARISCAL WORKS INCLUDING (POSSIBLE SOOT FURNACE), FOREGROUND, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. VIEW OF MARISCAL WORKS INCLUDING (POSSIBLE SOOT FURNACE), FOREGROUND, CONDENSERS, AND ORE BIN FOUNDATION ABOVE, LOOKING NORTHWEST. - Mariscal Quicksilver Mine & Reduction Works, Terlingua, Brewster County, TX

  12. South side elevation view includes small buildings for communications equipment ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    South side elevation view includes small buildings for communications equipment and cellular communications tower in background. - Chelan Butte Lookout, Summit of Chelan Butte, Chelan, Chelan County, WA

  13. West side elevation view includes small buildings for communications equipment ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    West side elevation view includes small buildings for communications equipment and cellular communications tower in background. - Chelan Butte Lookout, Summit of Chelan Butte, Chelan, Chelan County, WA

  14. General education teachers' relationships with included students with autism.

    PubMed

    Robertson, Kristen; Chamberlain, Brandt; Kasari, Connie

    2003-04-01

    In this study, we examine the relationship between general education teachers and second- and third-grade included students with autism. We also examine the effect of childrens' behavior problems on these relationships, as well as inclusion within the social environment of the classroom. Included students with autism form multidimensional relationships with their general education teachers. These relationships are associated with student's display of behavior problems and level of inclusion in the class. Specifically, when teachers perceived their relationships with included students with autism to be more positive, children's levels of behavioral problems were lower and they were more socially included in the class.

  15. Solar Energy Education. Reader, Part II. Sun story. [Includes glossary

    SciTech Connect

    Not Available

    1981-05-01

    Magazine articles which focus on the subject of solar energy are presented. The booklet prepared is the second of a four part series of the Solar Energy Reader. Excerpts from the magazines include the history of solar energy, mythology and tales, and selected poetry on the sun. A glossary of energy related terms is included. (BCS)

  16. 40 CFR 1502.14 - Alternatives including the proposed action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Alternatives including the proposed action. 1502.14 Section 1502.14 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.14 Alternatives including the proposed action. This section is the heart of...

  17. 40 CFR 1502.14 - Alternatives including the proposed action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Alternatives including the proposed action. 1502.14 Section 1502.14 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.14 Alternatives including the proposed action. This section is the heart of...

  18. 40 CFR 1502.14 - Alternatives including the proposed action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Alternatives including the proposed action. 1502.14 Section 1502.14 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.14 Alternatives including the proposed action. This section is the heart of...

  19. 40 CFR 1502.14 - Alternatives including the proposed action.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Alternatives including the proposed action. 1502.14 Section 1502.14 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.14 Alternatives including the proposed action. This section is the heart of...

  20. 2 CFR 200.470 - Taxes (including Value Added Tax).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Taxes (including Value Added Tax). 200.470... Cost § 200.470 Taxes (including Value Added Tax). (a) For states, local governments and Indian tribes... Federal government for the taxes, interest, and penalties. (c) Value Added Tax (VAT) Foreign taxes...

  1. Microfluidic devices and methods including porous polymer monoliths

    DOEpatents

    Hatch, Anson V; Sommer, Gregory J; Singh, Anup K; Wang, Ying-Chih; Abhyankar, Vinay V

    2014-04-22

    Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.

  2. 14 CFR 29.1181 - Designated fire zones: regions included.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Designated fire zones: regions included. 29... Protection § 29.1181 Designated fire zones: regions included. (a) Designated fire zones are— (1) The engine power section of reciprocating engines; (2) The engine accessory section of reciprocating engines;...

  3. 14 CFR 25.1181 - Designated fire zones; regions included.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Designated fire zones; regions included. 25... Protection § 25.1181 Designated fire zones; regions included. (a) Designated fire zones are— (1) The engine power section; (2) The engine accessory section; (3) Except for reciprocating engines, any...

  4. 14 CFR 23.1181 - Designated fire zones; regions included.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Designated fire zones; regions included. 23... Powerplant Powerplant Fire Protection § 23.1181 Designated fire zones; regions included. Designated fire zones are— (a) For reciprocating engines— (1) The power section; (2) The accessory section; (3)...

  5. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  6. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  7. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  8. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  9. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  10. Making Way and Making Sense: Including Newcomers in Interaction

    ERIC Educational Resources Information Center

    Pillet-Shore, Danielle

    2010-01-01

    In our everyday interactions as they unfold in real time, how do we do including? This article examines a specific set of interactional moments when the potential to be included (or not) recurs: when a newcomer arrives to some social scene where two or more already-present persons are actively engaged in some activity and that newcomer displays…

  11. 20 CFR 404.1312 - World War II service included.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  12. Microfluidic devices and methods including porous polymer monoliths

    SciTech Connect

    Hatch, Anson V.; Sommer, Gregory j.; Singh, Anup K.; Wang, Ying-Chih; Abhyankar, Vinay

    2015-12-01

    Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.

  13. 43 CFR 3902.24 - Associations, including partnerships.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Associations, including partnerships. 3902... Qualification Requirements § 3902.24 Associations, including partnerships. Associations that are applicants must... members of the association who own or control 10 percent or more of the association or partnership,...

  14. 43 CFR 3902.24 - Associations, including partnerships.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Associations, including partnerships. 3902... Qualification Requirements § 3902.24 Associations, including partnerships. Associations that are applicants must... members of the association who own or control 10 percent or more of the association or partnership,...

  15. 43 CFR 3902.24 - Associations, including partnerships.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Associations, including partnerships. 3902... Qualification Requirements § 3902.24 Associations, including partnerships. Associations that are applicants must... members of the association who own or control 10 percent or more of the association or partnership,...

  16. 43 CFR 3902.24 - Associations, including partnerships.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Associations, including partnerships. 3902... Qualification Requirements § 3902.24 Associations, including partnerships. Associations that are applicants must... members of the association who own or control 10 percent or more of the association or partnership,...

  17. 31 CFR 103.51 - Dollars as including foreign currency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Dollars as including foreign currency... RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS General Provisions § 103.51 Dollars as including foreign currency. Wherever in this part an amount is stated in dollars, it shall be deemed to...

  18. 142. ARAIII General plan of GCRE area, including electrical distribution ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    142. ARA-III General plan of GCRE area, including electrical distribution plan for power and lighting. Includes detail of floodlight and security lighting poles and fixtures. Aerojet-general 880-area/GCRE-406-1. Date: February 1958. Ineel index code no. 063-0406-00-013-102539. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

  19. 25 CFR 20.403 - What do protective services include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AND SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.403 What do protective services include? Protective services provided to a child, family or elderly person will be documented in... protective services; (2) Providing services to children, elderly, and families, including referrals...

  20. 7 CFR 201.7 - Purity (including variety).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Purity (including variety). 201.7 Section 201.7 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS Records for Agricultural and Vegetable Seeds § 201.7 Purity (including variety). The...

  1. 32 CFR 165.7 - Waivers (including reductions).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Waivers (including reductions). 165.7 Section... RECOUPMENT OF NONRECURRING COSTS ON SALES OF U.S. ITEMS § 165.7 Waivers (including reductions). (a) The “Arms... consideration of reductions or waivers for particular sales which, if made, significantly advance...

  2. 26 CFR 1.642(g)-2 - Deductions included.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Deductions included. 1.642(g)-2 Section 1.642(g... (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.642(g)-2 Deductions included. It is not required that the total deductions, or the total amount of any deduction, to which section 642(g)...

  3. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  4. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  5. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  6. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  7. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  8. 26 CFR 1.1013-1 - Property included in inventory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Property included in inventory. 1.1013-1 Section... inventory. The basis of property required to be included in inventory is the last inventory value of such property in the hands of the taxpayer. The requirements with respect to the valuation of an inventory...

  9. Including All Children in Standards-Based Physical Education.

    ERIC Educational Resources Information Center

    Johnson, Lynn V.; Kasser, Susan L.; Nichols, Beverly A.

    2002-01-01

    Discusses the inclusion of students with and without disabilities in physical education as the movement toward standards-based education progresses, examining whether standards should be applied to all students, obstacles to including all students, ways to include all students, and the importance of standards for teachers. An example of inclusive…

  10. 20 CFR 404.1312 - World War II service included.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  11. 20 CFR 404.1312 - World War II service included.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  12. 20 CFR 404.1312 - World War II service included.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  13. 20 CFR 404.1312 - World War II service included.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  14. Articles which include chevron film cooling holes, and related processes

    SciTech Connect

    Bunker, Ronald Scott; Lacy, Benjamin Paul

    2014-12-09

    An article is described, including an inner surface which can be exposed to a first fluid; an inlet; and an outer surface spaced from the inner surface, which can be exposed to a hotter second fluid. The article further includes at least one row or other pattern of passage holes. Each passage hole includes an inlet bore extending through the substrate from the inlet at the inner surface to a passage hole-exit proximate to the outer surface, with the inlet bore terminating in a chevron outlet adjacent the hole-exit. The chevron outlet includes a pair of wing troughs having a common surface region between them. The common surface region includes a valley which is adjacent the hole-exit; and a plateau adjacent the valley. The article can be an airfoil. Related methods for preparing the passage holes are also described.

  15. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids

    PubMed Central

    Moloudizargari, Milad; Mikaili, Peyman; Aghajanshakeri, Shahin; Asghari, Mohammad Hossein; Shayegh, Jalal

    2013-01-01

    Wild Syrian rue (Peganum harmala L. family Zygophyllaceae) is well-known in Iran and various parts of this plant including, its seeds, bark, and root have been used as folk medicine. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its active alkaloids, especially harmine and harmaline. Analytical studies on the chemical composition of the plant show that the most important constituents of this plant are beta-carboline alkaloids such as harmalol, harmaline, and harmine. Harmine is the most studied among these naturally occurring alkaloids. In addition to P. harmala (Syrian rue), these beta-carbolines are present in many other plants such as Banisteria caapi and are used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and individual active alkaloids of P. harmala (Syrian rue). PMID:24347928

  16. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids.

    PubMed

    Moloudizargari, Milad; Mikaili, Peyman; Aghajanshakeri, Shahin; Asghari, Mohammad Hossein; Shayegh, Jalal

    2013-07-01

    Wild Syrian rue (Peganum harmala L. family Zygophyllaceae) is well-known in Iran and various parts of this plant including, its seeds, bark, and root have been used as folk medicine. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its active alkaloids, especially harmine and harmaline. Analytical studies on the chemical composition of the plant show that the most important constituents of this plant are beta-carboline alkaloids such as harmalol, harmaline, and harmine. Harmine is the most studied among these naturally occurring alkaloids. In addition to P. harmala (Syrian rue), these beta-carbolines are present in many other plants such as Banisteria caapi and are used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and individual active alkaloids of P. harmala (Syrian rue).

  17. Turbomachine injection nozzle including a coolant delivery system

    DOEpatents

    Zuo, Baifang [Simpsonville, SC

    2012-02-14

    An injection nozzle for a turbomachine includes a main body having a first end portion that extends to a second end portion defining an exterior wall having an outer surface. A plurality of fluid delivery tubes extend through the main body. Each of the plurality of fluid delivery tubes includes a first fluid inlet for receiving a first fluid, a second fluid inlet for receiving a second fluid and an outlet. The injection nozzle further includes a coolant delivery system arranged within the main body. The coolant delivery system guides a coolant along at least one of a portion of the exterior wall and around the plurality of fluid delivery tubes.

  18. Electric drive systems including smoothing capacitor cooling devices and systems

    DOEpatents

    Dede, Ercan Mehmet; Zhou, Feng

    2017-02-28

    An electric drive system includes a smoothing capacitor including at least one terminal, a bus bar electrically coupled to the at least one terminal, a thermoelectric device including a first side and a second side positioned opposite the first side, where the first side is thermally coupled to at least one of the at least one terminal and the bus bar, and a cooling element thermally coupled to the second side of the thermoelectric device, where the cooling element dissipates heat from the thermoelectric device.

  19. High performance, durable polymers including poly(phenylene)

    DOEpatents

    Fujimoto, Cy; Pratt, Harry; Anderson, Travis Mark

    2017-02-28

    The present invention relates to functionalized polymers including a poly(phenylene) structure. In some embodiments, the polymers and copolymers of the invention include a highly localized concentration of acidic moieties, which facilitate proton transport and conduction through networks formed from these polymers. In addition, the polymers can include functional moieties, such as electron-withdrawing moieties, to protect the polymeric backbone, thereby extending its durability. Such enhanced proton transport and durability can be beneficial for any high performance platform that employs proton exchange polymeric membranes, such as in fuel cells or flow batteries.

  20. Contextual view including south (rear) of building 925, exercise in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view including south (rear) of building 925, exercise in foreground, and modern buildings in background. Facing northwest. - Travis Air Force Base, Building No. 925, W Street, Fairfield, Solano County, CA

  1. 1. AERIAL VIEW OF BRIDGE IN CONTEXT INCLUDING VICTORY CIRCLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. AERIAL VIEW OF BRIDGE IN CONTEXT INCLUDING VICTORY CIRCLE FROM SOUTH. LOOKING NORTH. - Rue Road Bridge, Rue Road, spanning Matchaponix Brook, .35 mile east of intersection with Route 613, Jamesburg, Middlesex County, NJ

  2. 13. EQUIPMENT USED IN CLEAN ROOM (102), INCLUDING ROYCO PARTICLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. EQUIPMENT USED IN CLEAN ROOM (102), INCLUDING ROYCO PARTICLE COUNTER (LEFT) AND STEREOSCOPE FOR MANUAL PARTICLE COUNTING (RIGHT) - Vandenberg Air Force Base, Space Launch Complex 3, Vehicle Support Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  3. Looking East on Third Floor of Pellet Plant Including Tops ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking East on Third Floor of Pellet Plant Including Tops of Line One and Blenders One, Two, and Three - Hematite Fuel Fabrication Facility, Pellet Plant, 3300 State Road P, Festus, Jefferson County, MO

  4. Looking South at North End of Rod Loading Line Including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking South at North End of Rod Loading Line Including Welding Area Within Rod Loading building - Hematite Fuel Fabrication Facility, Rod Loading Building, 3300 State Road P, Festus, Jefferson County, MO

  5. Looking Northwest Along South End of Rod Loading Building Including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking Northwest Along South End of Rod Loading Building Including Mezzanine and Gad Loading Area - Hematite Fuel Fabrication Facility, Rod Loading Building, 3300 State Road P, Festus, Jefferson County, MO

  6. Modeling Emergent Macrophyte Distributions: Including Sub-dominant Species

    EPA Science Inventory

    Mixed stands of emergent vegetation are often present following drawdowns but models of wetland plant distributions fail to include subdominant species when predicting distributions. Three variations of a spatial plant distribution cellular automaton model were developed to explo...

  7. 8. VIEW OF RADIOGRAPHY EQUIPMENT, TEST METHODS INCLUDED RADIOGRAPHY AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW OF RADIOGRAPHY EQUIPMENT, TEST METHODS INCLUDED RADIOGRAPHY AND BETA BACKSCATTERING. (7/13/56) - Rocky Flats Plant, Non-Nuclear Production Facility, South of Cottonwood Avenue, west of Seventh Avenue & east of Building 460, Golden, Jefferson County, CO

  8. Elevation view of front (east) side of milk barn includes ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation view of front (east) side of milk barn includes portion of creamery on left and main barn on right. - Kosai Farm, Milk Barn, B Street north of Northwest Twenty-ninth Street, Auburn, King County, WA

  9. Reduced Toxicity Fuel Satellite Propulsion System Including Plasmatron

    NASA Technical Reports Server (NTRS)

    Schneider, Steven J. (Inventor)

    2003-01-01

    A reduced toxicity fuel satellite propulsion system including a reduced toxicity propellant supply for consumption in an axial class thruster and an ACS class thruster. The system includes suitable valves and conduits for supplying the reduced toxicity propellant to the ACS decomposing element of an ACS thruster. The ACS decomposing element is operative to decompose the reduced toxicity propellant into hot propulsive gases. In addition the system includes suitable valves and conduits for supplying the reduced toxicity propellant to an axial decomposing element of the axial thruster. The axial decomposing element is operative to decompose the reduced toxicity propellant into hot gases. The system further includes suitable valves and conduits for supplying a second propellant to a combustion chamber of the axial thruster. whereby the hot gases and the second propellant auto-ignite and begin the combustion process for producing thrust.

  10. Interior view looking SW includes map hanging from ceiling and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view looking SW includes map hanging from ceiling and edge of fire finder stand on right. - Badger Mountain Lookout, .125 mile northwest of Badger Mountain summit, East Wenatchee, Douglas County, WA

  11. 4. Band Wheel and Walking Beam Mechanism, Including Remains of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Band Wheel and Walking Beam Mechanism, Including Remains of Frame Belt House, Looking Southeast - David Renfrew Oil Rig, East side of Connoquenessing Creek, 0.4 mile North of confluence with Thorn Creek, Renfrew, Butler County, PA

  12. Crane 55 at Drydock No. 2. View includes entire bone. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Crane 55 at Drydock No. 2. View includes entire bone. Building 43 is in background - Puget Sound Naval Shipyard, Portal Gantry Crane No. 55, Central Industrial Area, Farragut Avenue, Bremerton, Kitsap County, WA

  13. 5. EAST SPAN, FROM SOUTH, SHOWING STRUCTURAL CONFIGURATION, INCLUDING POLYGONAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. EAST SPAN, FROM SOUTH, SHOWING STRUCTURAL CONFIGURATION, INCLUDING POLYGONAL TOP CHORD, TRUSS PANELS, EAST ABUTMENT, AND CENTRAL PIER - Glendale Road Bridge, Spanning Deep Creek Lake on Glendale Road, McHenry, Garrett County, MD

  14. Initiatives to Develop Web Sites Including Information about Brownfields Properties

    EPA Pesticide Factsheets

    This web site was created to assist in planning, designing, and operating web sites that include information about individual brownfields properties. The report is of value to parties designing or managing such sites.

  15. 21 CFR 870.5300 - DC-defibrillator (including paddles).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... heart or to terminate other cardiac arrhythmias. This generic type of device includes low energy... defibrillating the atria or ventricles of the heart or to terminate other cardiac arrhythmias. The device...

  16. 21 CFR 870.5300 - DC-defibrillator (including paddles).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... heart or to terminate other cardiac arrhythmias. This generic type of device includes low energy... defibrillating the atria or ventricles of the heart or to terminate other cardiac arrhythmias. The device...

  17. 21 CFR 870.5300 - DC-defribrillator (including paddles).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... heart or to terminate other cardiac arrhythmias. This generic type of device includes low energy... defibrillating the atria or ventricles of the heart or to terminate other cardiac arrhythmias. The device...

  18. 21 CFR 870.5300 - DC-defribrillator (including paddles).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... heart or to terminate other cardiac arrhythmias. This generic type of device includes low energy... defibrillating the atria or ventricles of the heart or to terminate other cardiac arrhythmias. The device...

  19. 21 CFR 870.5300 - DC-defribrillator (including paddles).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... heart or to terminate other cardiac arrhythmias. This generic type of device includes low energy... defibrillating the atria or ventricles of the heart or to terminate other cardiac arrhythmias. The device...

  20. View looking south from sidewalk includes halfthrough west girder on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View looking south from sidewalk includes half-through west girder on left and raging river (upstream) on right. - Raging River Bridge No. 234A, Preston-Fall City Road & Southeast Forty-fourth Place, Fall City, King County, WA

  1. 24. POWER ROOM INTERIOR, DC WESTINGHOUSE EXCITER UNIT INCLUDING A ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. POWER ROOM INTERIOR, DC WESTINGHOUSE EXCITER UNIT INCLUDING A SHUNT WOUND GENERATOR AND FIELD RHEOSTAT, 1500 RPM, 85 VNL TO 15 VOLT 90 SFL - Death Valley Ranch, Power House, Death Valley Junction, Inyo County, CA

  2. Building No. 902, detail of Mechanical Room door, including vent ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Building No. 902, detail of Mechanical Room door, including vent and conduit - Presidio of San Francisco, Enlisted Men's Barracks Type, West end of Crissy Field, between Pearce & Maudlin Streets, San Francisco, San Francisco County, CA

  3. 21 CFR 886.1840 - Simulatan (including crossed cylinder).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... given object is clearly in focus, as the examiner uses different lenses). (b) Classification. Class I... cylinder). (a) Identification. A simulatan (including crossed cylinder) is a device that is a set of...

  4. 21 CFR 886.1840 - Simulatan (including crossed cylinder).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... given object is clearly in focus, as the examiner uses different lenses). (b) Classification. Class I... cylinder). (a) Identification. A simulatan (including crossed cylinder) is a device that is a set of...

  5. 12. SW corner of seating in Original Grandstand, including TV ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. SW corner of seating in Original Grandstand, including TV Center booth and reserved seating areas. Stairway above booth leads to turret on roof. Camera pointed SW. (May 1993) - Longacres, Original Grandstand, 1621 Southwest Sixteenth Street, Renton, King County, WA

  6. When Should Zero Be Included on a Scale Showing Magnitude?

    ERIC Educational Resources Information Center

    Kozak, Marcin

    2011-01-01

    This article addresses an important problem of graphing quantitative data: should one include zero on the scale showing magnitude? Based on a real time series example, the problem is discussed and some recommendations are proposed.

  7. View of North End of Oxide Building Interior Including Roof ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of North End of Oxide Building Interior Including Roof and Wall Juncture and Crane Trolley - Hematite Fuel Fabrication Facility, Oxide Building & Oxide Loading Dock, 3300 State Road P, Festus, Jefferson County, MO

  8. Looking West From rear (East) End of Office Building Including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking West From rear (East) End of Office Building Including Recycle Storage Area, Loading Docks, and Decontamination Zone - Hematite Fuel Fabrication Facility, Office, 3300 State Road P, Festus, Jefferson County, MO

  9. Looking South at south End of Green Room Including Scrubber ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking South at south End of Green Room Including Scrubber for Incinerator within Recycle Recovery Building - Hematite Fuel Fabrication Facility, Recycle Recovery Building, 3300 State Road P, Festus, Jefferson County, MO

  10. 41. OPERATING CORRIDOR PLAN AND SECTIONS, INCLUDING SOME ISOMETRIC DETAILS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. OPERATING CORRIDOR PLAN AND SECTIONS, INCLUDING SOME ISOMETRIC DETAILS. INEEL DRAWING NUMBER 200-0633-00-287-106455. FLUOR NUMBER 5775-CPP-633-P-60 - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  11. Stages of Plasma Cell Neoplasms (Including Multiple Myeloma)

    MedlinePlus

    ... Health Professional Plasma Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma Cell Neoplasms Go to Health Professional Version Key Points ...

  12. Treatment Options for Plasma Cell Neoplasms (Including Multiple Myeloma)

    MedlinePlus

    ... Health Professional Plasma Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma Cell Neoplasms Go to Health Professional Version Key Points ...

  13. 17. View of disassembled reduction gear parts including bull and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. View of disassembled reduction gear parts including bull and intermediate gears and pedestal bearing. - Hacienda Azucarera La Esperanza, Steam Engine & Mill, 2.65 Mi. N of PR Rt. 2 Bridge over Manati River, Manati, Manati Municipio, PR

  14. Pets: Your Plan Should Include All Family Members

    MedlinePlus

    ... Emergencies › Pets Pets Your Plan Should Include All Family Members The best way to protect your household ... Cabinet Red Cross Stories Governance Career Opportunities Military Families Disaster Relief What We Do Disaster Relief Health ...

  15. View of west end of Childs Powerhouse, including transformer station ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of west end of Childs Powerhouse, including transformer station and associated sheds. Looking downstream (east) - Childs-Irving Hydroelectric Project, Childs System, Childs Powerhouse, Forest Service Road 708/502, Camp Verde, Yavapai County, AZ

  16. 25 CFR 20.308 - What does earned income include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... profit, from activities by an employee or self-employed individual. Earned income includes: (a) Any one... self-employment, total profit from a business enterprise (i.e., gross receipts less expenses...

  17. 25 CFR 20.308 - What does earned income include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... profit, from activities by an employee or self-employed individual. Earned income includes: (a) Any one... self-employment, total profit from a business enterprise (i.e., gross receipts less expenses...

  18. 25 CFR 20.308 - What does earned income include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... profit, from activities by an employee or self-employed individual. Earned income includes: (a) Any one... self-employment, total profit from a business enterprise (i.e., gross receipts less expenses...

  19. 25 CFR 20.308 - What does earned income include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... profit, from activities by an employee or self-employed individual. Earned income includes: (a) Any one... self-employment, total profit from a business enterprise (i.e., gross receipts less expenses...

  20. INTERIOR VIEW WITH STOCK INCLUDING THESE GATE AND GLOBE VALVES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW WITH STOCK INCLUDING THESE GATE AND GLOBE VALVES FOR THE PULP AND PAPER INDUSTRIES READY FOR SHIPPING - Stockham Pipe & Fittings Company, Warehouse, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  1. Prototype solar heating and cooling systems, including potable hot water

    NASA Technical Reports Server (NTRS)

    Bloomquist, D.; Oonk, R. L.

    1977-01-01

    Progress made in the development, delivery, and support of two prototype solar heating and cooling systems including potable hot water is reported. The system consists of the following subsystems: collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition. A comparison of the proposed Solaron Heat Pump and Solar Desiccant Heating and Cooling Systems, installation drawings, data on the Akron House at Akron, Ohio, and other program activities are included.

  2. Good Security Practices for Electronic Commerce, Including Electronic Data Interchange

    DTIC Science & Technology

    1993-12-01

    FROM - TO) xx-xx-2002 to xx-xx-2002 4. TITLE AND SUBTITLE Good Security Practices for Electronic Commerce , Including Electronic Data Interchange...Report 12/1/1993 4. TITLE AND SUBTITLE Good Security Practices for Electronic Commerce , Including Electronic Data Interchange 5. FUNDING NUMBERS 6...Maximum 200 Words) Electronic commerce (EC) is the use of documents in electronic form, rather than paper, for carrying out functions of business or

  3. Inverse wing design in transonic flow including viscous interaction

    NASA Technical Reports Server (NTRS)

    Carlson, Leland A.; Ratcliff, Robert R.; Gally, Thomas A.; Campbell, Richard L.

    1989-01-01

    Several inverse methods were compared and initial results indicate that differences in results are primarily due to coordinate systems and fuselage representations and not to design procedures. Further, results from a direct-inverse method that includes 3-D wing boundary layer effects, wake curvature, and wake displacement are represented. These results show that boundary layer displacements must be included in the design process for accurate results.

  4. Hybrid powertrain system including smooth shifting automated transmission

    DOEpatents

    Beaty, Kevin D.; Nellums, Richard A.

    2006-10-24

    A powertrain system is provided that includes a prime mover and a change-gear transmission having an input, at least two gear ratios, and an output. The powertrain system also includes a power shunt configured to route power applied to the transmission by one of the input and the output to the other one of the input and the output. A transmission system and a method for facilitating shifting of a transmission system are also provided.

  5. [Origin of sennosides in health teas including Malva leaves].

    PubMed

    Kojima, T; Kishi, M; Sekita, S; Satake, M

    2001-06-01

    The aim of this study is to clarify whether sennosides are contained in the leaf of Malva verticillata L., and then to clarify the source of sennosides in health teas including malva leaves. The identification and determination of sennosides were performed with thin layer chromatography and high performance liquid chromatography. The leaf of Malva verticillata L. did not contain sennosides A or B and could be easily distinguished from senna leaf. Our previous report showed that sennosides are contained in weight-reducing herbal teas including malva leaves, and that senna leaf is a herbal component in some teas. Furthermore, in 10 samples of health tea including malva leaves that were bought last year, the smallest amount of sennosides was 6.1 mg/bag, and all health teas including malva leaves contained the leaf and midrib of senna. We suggest that sennosides A and B are not contained in the leaf of Malva verticillata L., and that the sennosides in health teas including malva leaves are not derived from malva leaf but from senna leaf.

  6. A sonic boom propagation model including mean flow atmospheric effects

    NASA Astrophysics Data System (ADS)

    Salamone, Joe; Sparrow, Victor W.

    2012-09-01

    This paper presents a time domain formulation of nonlinear lossy propagation in onedimension that also includes the effects of non-collinear mean flow in the acoustic medium. The model equation utilized is an augmented Burgers equation that includes the effects of nonlinearity, geometric spreading, atmospheric stratification, and also absorption and dispersion due to thermoviscous and molecular relaxation effects. All elements of the propagation are implemented in the time domain and the effects of non-collinear mean flow are accounted for in each term of the model equation. Previous authors have presented methods limited to showing the effects of wind on ray tracing and/or using an effective speed of sound in their model equation. The present work includes the effects of mean flow for all terms included in the augmented Burgers equation with all of the calculations performed in the time-domain. The capability to include the effects of mean flow in the acoustic medium allows one to make predictions more representative of real-world atmospheric conditions. Examples are presented for nonlinear propagation of N-waves and shaped sonic booms. [Work supported by Gulfstream Aerospace Corporation.

  7. A Framework for Including Family Health Spillovers in Economic Evaluation.

    PubMed

    Al-Janabi, Hareth; van Exel, Job; Brouwer, Werner; Coast, Joanna

    2016-02-01

    Health care interventions may affect the health of patients' family networks. It has been suggested that these "health spillovers" should be included in economic evaluation, but there is not a systematic method for doing this. In this article, we develop a framework for including health spillovers in economic evaluation. We focus on extra-welfarist economic evaluations where the objective is to maximize health benefits from a health care budget (the "health care perspective"). Our framework involves adapting the conventional cost-effectiveness decision rule to include 2 multiplier effects to internalize the spillover effects. These multiplier effects express the ratio of total health effects (for patients and their family networks) to patient health effects. One multiplier effect is specified for health benefit generated from providing a new intervention, one for health benefit displaced by funding this intervention. We show that using multiplier effects to internalize health spillovers could change the optimal funding decisions and generate additional health benefits to society.

  8. Model dielectric function for 2D semiconductors including substrate screening

    PubMed Central

    Trolle, Mads L.; Pedersen, Thomas G.; Véniard, Valerie

    2017-01-01

    Dielectric screening of excitons in 2D semiconductors is known to be a highly non-local effect, which in reciprocal space translates to a strong dependence on momentum transfer q. We present an analytical model dielectric function, including the full non-linear q-dependency, which may be used as an alternative to more numerically taxing ab initio screening functions. By verifying the good agreement between excitonic optical properties calculated using our model dielectric function, and those derived from ab initio methods, we demonstrate the versatility of this approach. Our test systems include: Monolayer hBN, monolayer MoS2, and the surface exciton of a 2 × 1 reconstructed Si(111) surface. Additionally, using our model, we easily take substrate screening effects into account. Hence, we include also a systematic study of the effects of substrate media on the excitonic optical properties of MoS2 and hBN. PMID:28117326

  9. Thin film solar cell including a spatially modulated intrinsic layer

    DOEpatents

    Guha, Subhendu; Yang, Chi-Chung; Ovshinsky, Stanford R.

    1989-03-28

    One or more thin film solar cells in which the intrinsic layer of substantially amorphous semiconductor alloy material thereof includes at least a first band gap portion and a narrower band gap portion. The band gap of the intrinsic layer is spatially graded through a portion of the bulk thickness, said graded portion including a region removed from the intrinsic layer-dopant layer interfaces. The band gap of the intrinsic layer is always less than the band gap of the doped layers. The gradation of the intrinsic layer is effected such that the open circuit voltage and/or the fill factor of the one or plural solar cell structure is enhanced.

  10. Solar Energy Education. Renewable energy: a background text. [Includes glossary

    SciTech Connect

    Not Available

    1985-01-01

    Some of the most common forms of renewable energy are presented in this textbook for students. The topics include solar energy, wind power hydroelectric power, biomass ocean thermal energy, and tidal and geothermal energy. The main emphasis of the text is on the sun and the solar energy that it yields. Discussions on the sun's composition and the relationship between the earth, sun and atmosphere are provided. Insolation, active and passive solar systems, and solar collectors are the subtopics included under solar energy. (BCS)

  11. Analysis and Synthesis of Microstrip Antennas Including Mutual Coupling

    DTIC Science & Technology

    1988-09-01

    E N 11. TITLE (/b*I* Secwfty OuodlCaUOn~) Analysis and Synthesis of Microstrip Antennas Including Mutual Coupling 12. PERSONAL AUTHOR(S) K~oichiro...GROUP SUB-GROUP Array Antennas, Microstrip Antennas, Array Analysis, Array Synthesis, Array Theory, Microwave Network Analysi! 19. ABSTRACT (Continue...VIRGI-J~NIA TECH ANALYSIS AND SYNTHESIS OF [. MICROSTRIP ANTENNAS INCLUDING MUTUAL COUPLING o0000 0 0 a o 0 0 0 0 0 o 0 00 0 00 o00000 0o000 0 0 0 a 0 0 0o

  12. Metal vapor laser including hot electrodes and integral wick

    DOEpatents

    Ault, Earl R.; Alger, Terry W.

    1995-01-01

    A metal vapor laser, specifically one utilizing copper vapor, is disclosed herein. This laser utilizes a plasma tube assembly including a thermally insulated plasma tube containing a specific metal, e.g., copper, and a buffer gas therein. The laser also utilizes means including hot electrodes located at opposite ends of the plasma tube for electrically exciting the metal vapor and heating its interior to a sufficiently high temperature to cause the metal contained therein to vaporize and for subjecting the vapor to an electrical discharge excitation in order to lase. The laser also utilizes external wicking arrangements, that is, wicking arrangements located outside the plasma tube.

  13. Metal vapor laser including hot electrodes and integral wick

    DOEpatents

    Ault, E.R.; Alger, T.W.

    1995-03-07

    A metal vapor laser, specifically one utilizing copper vapor, is disclosed herein. This laser utilizes a plasma tube assembly including a thermally insulated plasma tube containing a specific metal, e.g., copper, and a buffer gas therein. The laser also utilizes means including hot electrodes located at opposite ends of the plasma tube for electrically exciting the metal vapor and heating its interior to a sufficiently high temperature to cause the metal contained therein to vaporize and for subjecting the vapor to an electrical discharge excitation in order to lase. The laser also utilizes external wicking arrangements, that is, wicking arrangements located outside the plasma tube. 5 figs.

  14. Tunable cavity resonator including a plurality of MEMS beams

    DOEpatents

    Peroulis, Dimitrios; Fruehling, Adam; Small, Joshua Azariah; Liu, Xiaoguang; Irshad, Wasim; Arif, Muhammad Shoaib

    2015-10-20

    A tunable cavity resonator includes a substrate, a cap structure, and a tuning assembly. The cap structure extends from the substrate, and at least one of the substrate and the cap structure defines a resonator cavity. The tuning assembly is positioned at least partially within the resonator cavity. The tuning assembly includes a plurality of fixed-fixed MEMS beams configured for controllable movement relative to the substrate between an activated position and a deactivated position in order to tune a resonant frequency of the tunable cavity resonator.

  15. Methods of producing adsorption media including a metal oxide

    DOEpatents

    Mann, Nicholas R; Tranter, Troy J

    2014-03-04

    Methods of producing a metal oxide are disclosed. The method comprises dissolving a metal salt in a reaction solvent to form a metal salt/reaction solvent solution. The metal salt is converted to a metal oxide and a caustic solution is added to the metal oxide/reaction solvent solution to adjust the pH of the metal oxide/reaction solvent solution to less than approximately 7.0. The metal oxide is precipitated and recovered. A method of producing adsorption media including the metal oxide is also disclosed, as is a precursor of an active component including particles of a metal oxide.

  16. The International Project. 1992 Update. Including "Microfilming Projects Abroad."

    ERIC Educational Resources Information Center

    Rutimann, Hans

    This publication describes national and international book preservation programs, including: (l) the European Register of Microform Masters (EROMM), a cooperative effort in which the Commission on Preservation and Access is a partner; (2) national preservation programs in Germany, France, Ireland, Britain, Netherlands, Sweden, China, and Central…

  17. The Consequences of Including Seductive Details during Lecture

    ERIC Educational Resources Information Center

    Harp, Shannon F.; Maslich, Amy A.

    2005-01-01

    When text passages include seductive details (i.e., interesting, tangentially related adjuncts that are irrelevant to the lesson), students perform worse on recall (Garner, Gillingham, & White, 1989) and problem-solving tests (Harp & Mayer, 1997, 1998) than students reading the same material without seductive details. To determine whether…

  18. 40 CFR 1502.14 - Alternatives including the proposed action.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... impacts of the proposal and the alternatives in comparative form, thus sharply defining the issues and... alternatives which were eliminated from detailed study, briefly discuss the reasons for their having been... action so that reviewers may evaluate their comparative merits. (c) Include reasonable alternatives...

  19. Including Students with Disabilities in National Academic Assessments in Korea

    ERIC Educational Resources Information Center

    Choi, JongKeun; Lee, Daesik; Jung, Eunju

    2012-01-01

    In Korea, the effort to include students with disabilities in the educational accountability system has just begun. This paper reviews how Korean students with disabilities have been tested using the National Assessment of Educational Achievement (NAEA) and what issues have emerged as a result of the testing. Analysis of the 2009 and 2010 NAEA…

  20. TRUSS DETAILS. United Engineering Company Ltd., Alameda Shipyard. Includes crane ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TRUSS DETAILS. United Engineering Company Ltd., Alameda Shipyard. Includes crane girder section. No architect noted. Drawn by Penney. Plan no. 2-N-7. March 10, 1942, no revisions. U.S. Navy, Bureau of Yards & Docks, Contract no. bs 76, item no. 22A. Approved for construction October 9, 1943. blueprint - United Engineering Company Shipyard, Warehouse, 2900 Main Street, Alameda, Alameda County, CA

  1. 37 CFR 1.321 - Statutory disclaimers, including terminal disclaimers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Statutory disclaimers, including terminal disclaimers. 1.321 Section 1.321 Patents, Trademarks, and Copyrights UNITED STATES PATENT... that is not commonly owned but was disqualified as prior art as set forth in either §...

  2. 37 CFR 1.321 - Statutory disclaimers, including terminal disclaimers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Statutory disclaimers, including terminal disclaimers. 1.321 Section 1.321 Patents, Trademarks, and Copyrights UNITED STATES PATENT... that is not commonly owned but was disqualified as prior art as set forth in either §...

  3. Testing Intelligently Includes Double-Checking Wechsler IQ Scores

    ERIC Educational Resources Information Center

    Kuentzel, Jeffrey G.; Hetterscheidt, Lesley A.; Barnett, Douglas

    2011-01-01

    The rigors of standardized testing make for numerous opportunities for examiner error, including simple computational mistakes in scoring. Although experts recommend that test scoring be double-checked, the extent to which independent double-checking would reduce scoring errors is not known. A double-checking procedure was established at a…

  4. CONTROL ROOM WITH SPRINKLER SYSTEM CONTROLS, INCLUDING MANUAL CONTROL BOXES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTROL ROOM WITH SPRINKLER SYSTEM CONTROLS, INCLUDING MANUAL CONTROL BOXES FOR THE VENTILATION SYSTEM AND A PLC SWITCH FOR AUTOMATIC CO (CARBON MONOXIDE) SYSTEM. THE AIR TESTING SYSTEM IS FREE STANDING AND THE FANS ARE COMPUTER-OPERATED. - Alaskan Way Viaduct and Battery Street Tunnel, Seattle, King County, WA

  5. Information for Teachers (Including Classroom Activities), Skylab Student Project.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This program is intended to directly involve the educational community in space experiments, many of which can be related to existing curricula. Included in this first packet are: 1) a brief description of the Skylab Program and the National Science Teachers Association-National Aeronautics and Space Administration (NSTA-NASA) Skylab Student…

  6. 40 CFR 165.23 - Scope of pesticide products included.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Scope of pesticide products included. 165.23 Section 165.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL Nonrefillable Container Standards: Container Design and...

  7. 40 CFR 165.23 - Scope of pesticide products included.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Scope of pesticide products included. 165.23 Section 165.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL Nonrefillable Container Standards: Container Design and...

  8. 40 CFR 165.23 - Scope of pesticide products included.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Scope of pesticide products included. 165.23 Section 165.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL Nonrefillable Container Standards: Container Design and...

  9. 40 CFR 165.23 - Scope of pesticide products included.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Scope of pesticide products included. 165.23 Section 165.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL Nonrefillable Container Standards: Container Design and...

  10. Visual Impairments, "Including Blindness." NICHCY Disability Fact Sheet #13

    ERIC Educational Resources Information Center

    National Dissemination Center for Children with Disabilities, 2012

    2012-01-01

    Vision is one of the five senses. Being able to see gives tremendous access to learning about the world around--people's faces and the subtleties of expression, what different things look like and how big they are, and the physical environments, including approaching hazards. When a child has a visual impairment, it is cause for immediate…

  11. Including Leap Year in the Canonical Birthday Problem

    ERIC Educational Resources Information Center

    Nandor, M. J.

    2004-01-01

    The greatest benefit of including leap year in the calculation is not to increase precision, but to show students that a problem can be solved without such presumption. A birthday problem is analyzed showing that calculating a leap-year birthday probability is not a frivolous computation.

  12. Theory of nanorod antenna resonances including end-reflection phase

    NASA Astrophysics Data System (ADS)

    Su, Wei; Li, Xiangyin; Bornemann, Jens; Gordon, Reuven

    2015-04-01

    We present a fully analytic theory for nanorod resonances including the phase of reflection from the rounded ends using a transmission line approach. It combines the circuit theory response of spherical nanoparticles with standard transmission line theory using the Sommerfeld wave dispersion. The approach agrees well with comprehensive numerical calculations.

  13. 24 CFR 220.822 - Claim computation; items included.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Claim computation; items included. 220.822 Section 220.822 Housing and Urban Development Regulations Relating to Housing and...

  14. 24 CFR 220.822 - Claim computation; items included.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Claim computation; items included. 220.822 Section 220.822 Housing and Urban Development Regulations Relating to Housing and...

  15. 24 CFR 220.822 - Claim computation; items included.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Claim computation; items included. 220.822 Section 220.822 Housing and Urban Development Regulations Relating to Housing and...

  16. 24 CFR 220.822 - Claim computation; items included.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Claim computation; items included. 220.822 Section 220.822 Housing and Urban Development Regulations Relating to Housing and...

  17. Prototype solar heating and cooling systems including potable hot water

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Progress is reviewed in the development, delivery, and support of two prototype solar heating and cooling systems including potable hot water. The system consisted of the following subsystems: collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition.

  18. Oblique view of east and south sides, including component landscape ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Oblique view of east and south sides, including component landscape elements that surround the building, camera facing northwest - Naval Training Station, Senior Officers' Quarters District, Quarters No. 3, Naval Station Treasure Island, 3 Whiting Way, Yerba Buena Island, San Francisco, San Francisco County, CA

  19. 140. ARAIII Grading and drainage plan showing plot plan, including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    140. ARA-III Grading and drainage plan showing plot plan, including berms around waste storage tank and fuel oil storage tank. Aerojet-general 880-area-GCRE-101-1. Date: February 1958. Ineel index code no. 063-0101-00-013-102507. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

  20. 7. WEST PORTAL. NOTE DECORATIVE ELEMENTS, INCLUDING DECORATIVE CAPS COVERING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. WEST PORTAL. NOTE DECORATIVE ELEMENTS, INCLUDING DECORATIVE CAPS COVERING COMPRESSION BLOCKS. NAME OF THE BRIDGE COMPANY WITH HERALDIC CARTOUCHE BEARING NAMES OF THREE COUNTY COMMISSIONERS BELOW, AND OPEN SCROLL WORK IN WROUGHT IRON. - Peevy Road Bridge, Peevy Road spanning Perkiomen Creek in Upper Hanover Township, East Greenville, Montgomery County, PA

  1. Including Children with Cochlear Implants in General Education Elementary Classrooms

    ERIC Educational Resources Information Center

    Stith, Joanna L.; Drasgow, Erik

    2005-01-01

    Cochlear implants can provide partial hearing to individuals with substantial hearing loss. Because of improvements in early identification and intervention, more children with cochlear implants will be included in elementary school general education classrooms. Thus, general education teachers should be prepared for teaching children with…

  2. 36 CFR 1254.94 - What must my request include?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true What must my request include? 1254.94 Section 1254.94 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Microfilming...

  3. 36 CFR 1254.94 - What must my request include?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false What must my request include? 1254.94 Section 1254.94 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Microfilming...

  4. 36 CFR 1254.94 - What must my request include?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false What must my request include? 1254.94 Section 1254.94 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Microfilming...

  5. 36 CFR 1254.94 - What must my request include?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What must my request include? 1254.94 Section 1254.94 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Microfilming...

  6. Restructuring the Public School Curriculum To Include Parenting Education Classes.

    ERIC Educational Resources Information Center

    Tyree, Carolyn L.; And Others

    Although the current educational climate stresses a back-to-basics approach, there is nonetheless overwhelming evidence of a need for an appropriately structured parenting education program in the public school curriculum. Reasons for this need include the large number of teenage pregnancies and abortions. These lead teens to miss high school…

  7. DISC BRAKE SYSTEM (CENTER), INCLUDING BELT DRIVE TO SECONDARY GENERAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DISC BRAKE SYSTEM (CENTER), INCLUDING BELT DRIVE TO SECONDARY GENERAL MOTORS ENGINE (LEFT)AND FERREL REDUCTION GEAR CONNECTION TO ALLIS-CHALMERS DIESEL ENGINE (RIGHT), LOOKING NORTH. NOTE TORQUE CONVERTER (TOP) AND THROTTLE (BELOW) LINES CONNECTING TO PRIMARY ENGINE. - Mad River Glen, Single Chair Ski Lift, 62 Mad River Glen Resort Road, Fayston, Washington County, VT

  8. Including History in the Study of Psychological and Political Power

    ERIC Educational Resources Information Center

    Reich, Stephanie M.; Pinkard, Tracy; Davidson, Heather

    2008-01-01

    Isaac Prilleltensky's (2003) concept of psychopolitical validity stresses the need to consider both the political and the psychological nature of power in the study of wellness, oppression, and liberation. The authors advocate that psychopolitical validity would be strengthened if it included an explicit appreciation of historical context. The…

  9. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  10. 24 CFR 220.822 - Claim computation; items included.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Claim computation; items included. 220.822 Section 220.822 Housing and Urban Development Regulations Relating to Housing and...

  11. 31 CFR 306.87 - Partnerships (including nominee partnerships).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GOVERNING U.S. SECURITIES Assignments in Behalf of Private or Public Organizations § 306.87 Partnerships... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Partnerships (including nominee partnerships). 306.87 Section 306.87 Money and Finance: Treasury Regulations Relating to Money and...

  12. 31 CFR 306.87 - Partnerships (including nominee partnerships).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... GOVERNING U.S. SECURITIES Assignments in Behalf of Private or Public Organizations § 306.87 Partnerships... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Partnerships (including nominee partnerships). 306.87 Section 306.87 Money and Finance: Treasury Regulations Relating to Money and...

  13. 10 CFR 905.11 - What must an IRP include?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... data (such as service area, geographical characteristics, customer mix, historical loads, projected... consumer. (iii) Considerations that may be used to develop potential options include cost, market potential... customer must make the load forecasting data available to Western upon request. (6) Measurement...

  14. 48 CFR 536.213-370 - Bids that include alternates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Special Aspects of... features essential to a sound and adequate building design. If it appears that funds available for a project may be insufficient to include all desired features in the base bid, you may issue a...

  15. 48 CFR 536.213-370 - Bids that include alternates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Special Aspects of... features essential to a sound and adequate building design. If it appears that funds available for a project may be insufficient to include all desired features in the base bid, you may issue a...

  16. Mixture including hydrogen and hydrocarbon having pressure-temperature stability

    NASA Technical Reports Server (NTRS)

    Mao, Wendy L. (Inventor); Mao, Ho-Kwang (Inventor)

    2009-01-01

    The invention relates to a method of storing hydrogen that employs a mixture of hydrogen and a hydrocarbon that can both be used as fuel. In one embodiment, the method involves maintaining a mixture including hydrogen and a hydrocarbon in the solid state at ambient pressure and a temperature in excess of about 10 K.

  17. cDNA encoding a polypeptide including a hevein sequence

    DOEpatents

    Raikhel, N.V.; Broekaert, W.F.; Namhai Chua; Kush, A.

    1993-02-16

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1,018 nucleotides long and includes an open reading frame of 204 amino acids.

  18. A Guide to Running a Recycling Project. [Includes Recycling Handbook].

    ERIC Educational Resources Information Center

    Oregon Recycling Information and Organizing Network, Portland.

    This guide, designed for both students and adults, is intended for individuals who feel they might be interested in establishing a recycling depot. The guide includes such pertinent information as deciding how to set up a depot, markets and transportation, preparation of materials, where to place the depot and when to operate it, publicity and…

  19. IET area plot and utilities plan. Includes drainage. Ralph M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    IET area plot and utilities plan. Includes drainage. Ralph M. Parsons 902-4-ANP-U-310. Date: February 1954. Approved by INEEL Classification Office for public release. INEEL code no. 035-0100-00-693-106898 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

  20. Interviewing Objects: Including Educational Technologies as Qualitative Research Participants

    ERIC Educational Resources Information Center

    Adams, Catherine A.; Thompson, Terrie Lynn

    2011-01-01

    This article argues the importance of including significant technologies-in-use as key qualitative research participants when studying today's digitally enhanced learning environments. We gather a set of eight heuristics to assist qualitative researchers in "interviewing" technologies-in-use (or other relevant objects), drawing on concrete…

  1. Including Parents in School Governance: Rhetoric or Reality

    ERIC Educational Resources Information Center

    Ng, Shun Wing

    2013-01-01

    Purpose: The purpose of this paper is to report a qualitative study exploring how parents have been included in school governance in Hong Kong and in what ways their roles have been evolving in state education. Design/methodology/approach: The qualitative method was adopted in this exploratory study, the findings of which help provide insights for…

  2. Fluidics research, including vortex and jet pipe valves

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The research at the Systems and Control Laboratory is reported. Topics discussed include: response characteristics of laminar fluidic amplifiers, power amplification with a vortex valve, pulse-supply-mode fluidics, speed control system employing a jet pipe valve, and the fluidics reference center.

  3. 30 CFR 250.1007 - What to include in applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... mitigation measures such as the use of helical strakes or anchoring devices. (5) The application shall... schematic drawing showing the size, weight, grade, wall thickness, and type of line pipe and risers; pressure-regulating devices (including back-pressure regulators); sensing devices with associated...

  4. 30 CFR 250.1007 - What to include in applications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... applicable regulations. (2) A schematic drawing showing the size, weight, grade, wall thickness, and type of line pipe and risers; pressure-regulating devices (including back-pressure regulators); sensing devices... external pipeline coating system; (iii) Description of internal protective measures; (iv) Specific...

  5. Excellence in Faculty Evaluation...Includes Faculty Buy-in!

    ERIC Educational Resources Information Center

    Andrews, Hans A.; Erwin, John

    This document presents the results of a forum on faculty evaluation that took place at the 1999 conference of the American Association of Community Colleges. Thirty-four persons participated in the dialogue, including 31 Deans, Vice-Presidents of Instruction or Students, and Presidents; and 3 faculty members. Participants were asked to respond to…

  6. 37. PLAN OF ACCESS CORRIDOR PIPING INCLUDES WASTE HOLD TANK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. PLAN OF ACCESS CORRIDOR PIPING INCLUDES WASTE HOLD TANK CELL, OFFGAS CELL, ADSORBER CELL, AND OFFGAS FILTER CELL. INEEL DRAWING NUMBER 200-0633-00-287-106453. FLUOR NUMBER 5775-CPP-P-58. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  7. 38. SECTIONS OF ACCESS CORRIDOR, INCLUDES SECTION SHOWING ARRANGEMENT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. SECTIONS OF ACCESS CORRIDOR, INCLUDES SECTION SHOWING ARRANGEMENT OF NAVY GUN BARRELS. INEEL DRAWING NUMBER 200-0633-00-287-106454. FLUOR NUMBER 5775-CPP-633-P-59. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID

  8. 34 CFR 429.20 - What must an application include?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What must an application include? 429.20 Section 429.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BILINGUAL VOCATIONAL MATERIALS, METHODS, AND TECHNIQUES...

  9. Including Non-Traditional Instrumentation in Undergraduate Environmental Chemistry Courses

    ERIC Educational Resources Information Center

    Jenkins, J. David; Orvis, Jessica N.; Smith, C. Jimmy; Manley, Citabria; Rice, Jeanette K. 2

    2004-01-01

    Non-traditional instrumentation was obtained for Georgia Southern undergraduates to attain fundamental environmental education through unique laboratory experiences. In this context, the method for including a direct mercury analyzer into both major and non-major environmental laboratories is reported.

  10. 25 CFR 20.403 - What do protective services include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... allegations of child abuse and neglect, abandonment, and conditions that may require referrals (such as mental... AND SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.403 What do protective services include? Protective services provided to a child, family or elderly person will be documented...

  11. 25 CFR 20.403 - What do protective services include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... allegations of child abuse and neglect, abandonment, and conditions that may require referrals (such as mental... AND SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.403 What do protective services include? Protective services provided to a child, family or elderly person will be documented...

  12. 25 CFR 20.403 - What do protective services include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of child abuse and neglect, abandonment, and conditions that may require referrals (such as mental or... SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.403 What do protective services include? Protective services provided to a child, family or elderly person will be documented in the...

  13. 30 CFR 250.1007 - What to include in applications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 250.1007 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE... showing major features and other pertinent data including area, lease, and block designations; water... schematic drawing shall also show input source(s), e.g., wells, pumps, compressors, and vessels;...

  14. 30 CFR 250.1007 - What to include in applications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 250.1007 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE... showing major features and other pertinent data including area, lease, and block designations; water... schematic drawing shall also show input source(s), e.g., wells, pumps, compressors, and vessels;...

  15. 30 CFR 250.1007 - What to include in applications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 250.1007 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE... showing major features and other pertinent data including area, lease, and block designations; water... schematic drawing shall also show input source(s), e.g., wells, pumps, compressors, and vessels;...

  16. 13. Historic drawing of rocket engine test facility layout, including ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic drawing of rocket engine test facility layout, including Buildings 202, 205, 206, and 206A, February 3, 1984. NASA GRC drawing number CF-101539. On file at NASA Glenn Research Center. - Rocket Engine Testing Facility, NASA Glenn Research Center, Cleveland, Cuyahoga County, OH

  17. 14 CFR 29.1181 - Designated fire zones: regions included.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... sections of turbine engine installations except sections that do not contain lines and components carrying... Protection § 29.1181 Designated fire zones: regions included. (a) Designated fire zones are— (1) The engine power section of reciprocating engines; (2) The engine accessory section of reciprocating engines;...

  18. 14 CFR 29.1181 - Designated fire zones: regions included.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... sections of turbine engine installations except sections that do not contain lines and components carrying... Protection § 29.1181 Designated fire zones: regions included. (a) Designated fire zones are— (1) The engine power section of reciprocating engines; (2) The engine accessory section of reciprocating engines;...

  19. Catalog of Programmed Instructional Material. (Including Change I).

    ERIC Educational Resources Information Center

    Bureau of Naval Personnel, Washington, DC.

    A catalog lists programed instruction material for military tasks that has been developed by the U.S. Navy. Part one of the catalog lists programed material alphabetically by subject area. Information provided for each program includes title, classification, identification code to be used when requesting copies of the program, population for whom…

  20. Assessing the Doctoral Thesis When It Includes Published Work

    ERIC Educational Resources Information Center

    Sharmini, Sharon; Spronken-Smith, Rachel; Golding, Clinton; Harland, Tony

    2015-01-01

    In this article we explore how examiners assess a thesis that includes published work. An online survey was used to gather data on approaches to assessing publication-based theses (PBTs). The respondents were 62 supervisors who had experience examining PBTs across a range of disciplines at a research-intensive university in New Zealand. Nearly…

  1. 1. Context view includes Building 59 (second from left). Camera ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Context view includes Building 59 (second from left). Camera is pointed ENE along Farragut Aveune. Buildings on left side of street are, from left: Building 856, Building 59 and Building 107. On right side of street they are, from right; Building 38, Building 452 and Building 460. - Puget Sound Naval Shipyard, Pattern Shop, Farragut Avenue, Bremerton, Kitsap County, WA

  2. 30 CFR 250.211 - What must the EP include?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....211 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and.... Examples of exploration activities include exploration drilling, well test flaring, installing a...

  3. 30 CFR 550.211 - What must the EP include?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....211 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... include exploration drilling, well test flaring, installing a well protection structure, and temporary... well and the locations of all associated drilling unit anchors. (c) Drilling unit. A description of...

  4. 30 CFR 550.211 - What must the EP include?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....211 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... include exploration drilling, well test flaring, installing a well protection structure, and temporary... well and the locations of all associated drilling unit anchors. (c) Drilling unit. A description of...

  5. 30 CFR 550.211 - What must the EP include?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....211 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... include exploration drilling, well test flaring, installing a well protection structure, and temporary... well and the locations of all associated drilling unit anchors. (c) Drilling unit. A description of...

  6. 10 CFR 905.11 - What must an IRP include?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... contracts and conventional and renewable generation options. (ii) Demand-side options alter the customer's... resources that evaluates the full range of alternatives, including new generating capacity, power purchases... renewable energy resources, to provide adequate and reliable service to a customer's electric consumers....

  7. 10 CFR 905.11 - What must an IRP include?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... contracts and conventional and renewable generation options. (ii) Demand-side options alter the customer's... resources that evaluates the full range of alternatives, including new generating capacity, power purchases... renewable energy resources, to provide adequate and reliable service to a customer's electric consumers....

  8. 10 CFR 905.11 - What must an IRP include?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... contracts and conventional and renewable generation options. (ii) Demand-side options alter the customer's... resources that evaluates the full range of alternatives, including new generating capacity, power purchases... renewable energy resources, to provide adequate and reliable service to a customer's electric consumers....

  9. 10 CFR 905.11 - What must an IRP include?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... contracts and conventional and renewable generation options. (ii) Demand-side options alter the customer's... resources that evaluates the full range of alternatives, including new generating capacity, power purchases... renewable energy resources, to provide adequate and reliable service to a customer's electric consumers....

  10. Payment Services for Global Online Systems Including Internet.

    ERIC Educational Resources Information Center

    Seebeck, Bill; And Others

    1995-01-01

    A panel of four conference presenters address issues related to paying for services provided through online systems. Discussion includes the following topics: metering devices; electronic/digital cash; working within existing banking/credit card structures; provision of payment mechanisms in countries without extensive credit card usage; and…

  11. Including Children with Hearing Loss in Early Childhood Programs

    ERIC Educational Resources Information Center

    Katz, Laurie; Schery, Teris K.

    2006-01-01

    These are typical scenarios of children with hearing loss who are being included increasingly in early childhood settings. Recent federal legislation encourages states to develop programs to screen the hearing of all infants before they leave the hospital, and currently 39 states have adopted newborn infant hearing screening mandates (ASHA 2005).…

  12. 3. GENERAL VIEW, INCLUDING NORTH AND WEST ELEVATIONS (CROPPED PRINT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. GENERAL VIEW, INCLUDING NORTH AND WEST ELEVATIONS (CROPPED PRINT FROM 2-1/4 x 2-3/4 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  13. XFEL OSCILLATOR SIMULATION INCLUDING ANGLE-DEPENDENT CRYSTAL REFLECTIVITY

    SciTech Connect

    Fawley, William; Lindberg, Ryan; Kim, K-J; Shvyd'ko, Yuri

    2010-08-23

    The oscillator package within the GINGER FEL simulation code has now been extended to include angle-dependent reflectivity properties of Bragg crystals. Previously, the package was modified to include frequencydependent reflectivity in order to model x-ray FEL oscillators from start-up from shot noise through to saturation. We present a summary of the algorithms used for modeling the crystal reflectivity and radiation propagation outside the undulator, discussing various numerical issues relevant to the domain of high Fresnel number and efficient Hankel transforms. We give some sample XFEL-O simulation results obtained with the angle-dependent reflectivity model, with particular attention directed to the longitudinal and transverse coherence of the radiation output.

  14. Microfluidic System Simulation Including the Electro-Viscous Effect

    NASA Technical Reports Server (NTRS)

    Rojas, Eileen; Chen, C. P.; Majumdar, Alok

    2007-01-01

    This paper describes a practical approach using a general purpose lumped-parameter computer program, GFSSP (Generalized Fluid System Simulation Program) for calculating flow distribution in a network of micro-channels including electro-viscous effects due to the existence of electrical double layer (EDL). In this study, an empirical formulation for calculating an effective viscosity of ionic solutions based on dimensional analysis is described to account for surface charge and bulk fluid conductivity, which give rise to electro-viscous effect in microfluidics network. Two dimensional slit micro flow data was used to determine the model coefficients. Geometry effect is then included through a Poiseuille number correlation in GFSSP. The bi-power model was used to calculate flow distribution of isotropically etched straight channel and T-junction microflows involving ionic solutions. Performance of the proposed model is assessed against experimental test data.

  15. The bispectrum of cosmic string temperature fluctuations including recombination effects

    SciTech Connect

    Regan, Donough; Hindmarsh, Mark E-mail: m.b.hindmarsh@sussex.ac.uk

    2015-10-01

    We calculate the cosmic microwave background temperature bispectrum from cosmic strings, including the contributions from the last scattering surface, using a well-established Gaussian model for the string energy-momentum correlation functions, and a simplified model for the cosmic fluid. We check our approximation for the integrated Sachs-Wolfe (ISW) contribution against the bispectrum obtained from the full sky map of the cosmic string ISW signal used by the Planck team, obtaining good agreement. We validate our model for the last scattering surface contribution by comparing the predicted temperature power spectrum with that obtained from a full Boltzmann code treatment applied to the Unconnected Segment Model of a string network. We find that including the last scattering contribution has only a small impact on the upper limit on the string tension resulting from the bispectrum at Planck resolutions, and argue that the bispectrum is unlikely to be competitive with the power spectrum at any resolution.

  16. Iterative optimal subcritical aerodynamic design code including profile drag

    NASA Technical Reports Server (NTRS)

    Kuhlman, J. M.

    1983-01-01

    A subcritical aerodynamic design computer code has been developed, which uses linearized aerodynamics along with sweep theory and airfoil data to obtain minimum total drag preliminary designs for multiple planform configurations. These optimum designs consist of incidence distributions yielding minimum total drag at design values of Mach number and lift and pitching moment coefficients. Linear lofting is used between airfoil stations. Solutions for isolated transport wings have shown that the solution is unique, and that including profile drag effects decreases tip loading and incidence relative to values obtained for minimum induced drag solutions. Further, including effects of variation of profile drag with Reynolds number can cause appreciable changes in the optimal design for tapered wings. Example solutions are also discussed for multiple planform configurations.

  17. Unsteady three-dimensional marginal separation, including breakdown

    NASA Technical Reports Server (NTRS)

    Duck, Peter W.

    1990-01-01

    A situation involving a three-dimensional marginal separation is considered, where a (steady) boundary layer flow is on the verge of separating at a point (located along a line of symmetry/centerline). At this point, a triple-deck is included, thereby permitting a small amount of interaction to occur. Unsteadiness is included within this interaction region through some external means. It is shown that the problem reduces to the solution of a nonlinear, unsteady, partial-integro system, which is solved numerically by means of time-marching together with a pseudo-spectral method spatially. A number of solutions to this system are presented which strongly suggest a breakdown of this system may occur, at a finite spatial position, at a finite time. The structure and details of this breakdown are then described.

  18. Simulating synchrotron radiation in accelerators including diffuse and specular reflections

    NASA Astrophysics Data System (ADS)

    Dugan, G.; Sagan, D.

    2017-02-01

    An accurate calculation of the synchrotron radiation flux within the vacuum chamber of an accelerator is needed for a number of applications. These include simulations of electron cloud effects and the design of radiation masking systems. To properly simulate the synchrotron radiation, it is important to include the scattering of the radiation at the vacuum chamber walls. To this end, a program called synrad3d has been developed which simulates the production and propagation of synchrotron radiation using a collection of photons. Photons generated by a charged particle beam are tracked from birth until they strike the vacuum chamber wall where the photon is either absorbed or scattered. Both specular and diffuse scattering is simulated. If a photon is scattered, it is further tracked through multiple encounters with the wall until it is finally absorbed. This paper describes the synrad3d program, with a focus on the details of its scattering model, and presents some examples of the program's use.

  19. Suddenly included: cultural differences in experiencing re-inclusion.

    PubMed

    Pfundmair, Michaela; Graupmann, Verena; Du, Hongfei; Frey, Dieter; Aydin, Nilüfer

    2015-03-01

    In the current research, we examined whether re-inclusion (i.e. the change from a previous state of exclusion to a new state of inclusion) was perceived differently by people with individualistic and collectivistic cultural backgrounds. Individualists (German and Austrian participants) but not collectivists (Chinese participants) experienced re-inclusion differently than continued inclusion: While collectivistic participants did not differentiate between both kinds of inclusion, individualistic participants showed reduced fulfilment of their psychological needs under re-inclusion compared to continued inclusion. The results moreover revealed that only participants from individualistic cultures expressed more feelings of exclusion when re-included than when continually included. These exclusionary feelings partially mediated the relationship between the different states of inclusion and basic need fulfilment.

  20. Sonic-boom-induced building structure responses including damage.

    NASA Technical Reports Server (NTRS)

    Clarkson, B. L.; Mayes, W. H.

    1972-01-01

    Concepts of sonic-boom pressure loading of building structures and the associated responses are reviewed, and results of pertinent theoretical and experimental research programs are summarized. The significance of sonic-boom load time histories, including waveshape effects, are illustrated with the aid of simple structural elements such as beams and plates. Also included are discussions of the significance of such other phenomena as three-dimensional loading effects, air cavity coupling, multimodal responses, and structural nonlinearities. Measured deflection, acceleration, and strain data from laboratory models and full-scale building tests are summarized, and these data are compared, where possible, with predicted values. Damage complaint and claim experience due both to controlled and uncontrolled supersonic flights over communities are summarized with particular reference to residential, commercial, and historic buildings. Sonic-boom-induced building responses are compared with those from other impulsive loadings due to natural and cultural events and from laboratory simulation tests.

  1. GNSS-Based Space Weather Systems Including COSMIC Ionospheric Measurements

    NASA Technical Reports Server (NTRS)

    Komjathy, Attila; Mandrake, Lukas; Wilson, Brian; Iijima, Byron; Pi, Xiaoqing; Hajj, George; Mannucci, Anthony J.

    2006-01-01

    The presentation outline includes University Corporation for Atmospheric Research (UCAR) and Jet Propulsion Laboratory (JPL) product comparisons, assimilating ground-based global positioning satellites (GPS) and COSMIC into JPL/University of Southern California (USC) Global Assimilative Ionospheric Model (GAIM), and JPL/USC GAIM validation. The discussion of comparisons examines Abel profiles and calibrated TEC. The JPL/USC GAIM validation uses Arecibo ISR, Jason-2 VTEC, and Abel profiles.

  2. Pump for spawning channels includes a turbine and motor. Turbine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Pump for spawning channels includes a turbine and motor. Turbine is Berkeley H-17500, model 8C2PH, Serial No. 2889, B.M. No. 4886 - Berkeley Pump Co. The Motor is G.E. Induction Motor, model 5K4256XA3YI, serial no. GAJ728337, Tri-Clad. View looking northeast. - Prairie Creek Fish Hatchery, Hwy. 101, Orick, Humboldt County, CA

  3. EXTERIOR VIEW WITH HISTORIC LOCOMOTIVES, COAL AND PASSENGER CARS INCLUDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW WITH HISTORIC LOCOMOTIVES, COAL AND PASSENGER CARS INCLUDING THE WOODWARD IRON COMPANY NO. 38 LOCOMOTIVE AND TENDER LOCATED IN THE HEART OF DIXIE MUSEUM'S POWELL AVENUE YARD AND SOUTHERN RAILROAD BOXCARS ON ACTIVE TRACKS OF BIRMINGHAM'S RAILROAD RESERVATION. IN BACKGROUND AT RIGHT AND CENTER IS THE BIRMINGHAM CITY CENTER. - Heart of Dixie Railroad, Rolling Stock, 1800 Block Powell Avenue, Birmingham, Jefferson County, AL

  4. Roof plan, Combat Operations Center, Building No. 2605. (Also includes ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Roof plan, Combat Operations Center, Building No. 2605. (Also includes a typical roof section, with new fiberglass and urethane insulation layers.) By Federal Builders, 575 Carreon Drive, Colton, California. Sheet 1 of 1, dated 18 May 1992. Scale one-eighth inch to one foot. 24x36 inches. ink on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

  5. Rehabilitation of a triple amputee including a hip disarticulation.

    PubMed

    Shin, J C; Park, C I; Kim, Y C; Jang, S H; Bang, I K; Shin, J S

    1998-12-01

    A multiple amputee more severe than a triple amputee is uncommon. There have been no reports on the rehabilitation outcome of a triple amputee, including hip disarticulation and transtibial amputation. The authors report the rehabilitation of a patient with left hip disarticulation, right trans-tibial amputation, and left trans-humeral amputation due to a train accident. He has successfully completed the rehabilitation programme and has become independent in prosthetic ambulation, activities of daily living, and driving.

  6. A Monograph of Papuan Psychodidae, Including Phlebotomus (Diptera)

    DTIC Science & Technology

    1967-10-10

    Phlebotomus utilize dark, shaded areas for daytime resting sites, which include tree holes and bark crevices, the interspaces of tree buttresses...L. & S. Quate. Specimens of this species were taken in permanently shaded parts of low-lying virgin rain forest. In this habitat they were collected...only other psychodine which lacks the eye bridges and might be confused with Notiocnaris is Paratelmatoscopus. The features of the wing venation and

  7. Interventions to Prevent Sexually Transmitted Infections, Including HIV Infection

    PubMed Central

    Cates, Willard

    2011-01-01

    The Centers for Disease Control and Prevention (CDC) Sexually Transmitted Disease (STD) Treatment Guidelines were last updated in 2006. To update the “Clinical Guide to Prevention Services” section of the 2010 CDC STD Treatment Guidelines, we reviewed the recent science with reference to interventions designed to prevent acquisition of STDs, including human immunodeficiency virus (HIV) infection. Major interval developments include (1) licensure and uptake of immunization against genital human papillomavirus, (2) validation of male circumcision as a potent prevention tool against acquisition of HIV and some other sexually transmitted infections (STIs), (3) failure of a promising HIV vaccine candidate to afford protection against HIV acquisition, (4) encouragement about the use of antiretroviral agents as preexposure prophylaxis to reduce risk of HIV and herpes simplex virus acquisition, (5) enhanced emphasis on expedited partner management and rescreening for persons infected with Chlamydia trachomatis and Neisseria gonorrhoeae, (6) recognition that behavioral interventions will be needed to address a new trend of sexually transmitted hepatitis C among men who have sex with men, and (7) the availability of a modified female condom. A range of preventive interventions is needed to reduce the risks of acquiring STI, including HIV infection, among sexually active people, and a flexible approach targeted to specific populations should integrate combinations of biomedical, behavioral, and structural interventions. These would ideally involve an array of prevention contexts, including (1) communications and practices among sexual partners, (2) transactions between individual clients and their healthcare providers, and (3) comprehensive population-level strategies for prioritizing prevention research, ensuring accurate outcome assessment, and formulating health policy. PMID:22080271

  8. Tuneable photonic device including an array of metamaterial resonators

    DOEpatents

    Brener, Igal; Wanke, Michael; Benz, Alexander

    2017-03-14

    A photonic apparatus includes a metamaterial resonator array overlying and electromagnetically coupled to a vertically stacked plurality of quantum wells defined in a semiconductor body. An arrangement of electrical contact layers is provided for facilitating the application of a bias voltage across the quantum well stack. Those portions of the semiconductor body that lie between the electrical contact layers are conformed to provide an electrically conductive path between the contact layers and through the quantum well stack.

  9. 12. FLOOR BEAMS, BRACKETS, STRINGERS. (Also includes a schedule of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. FLOOR BEAMS, BRACKETS, STRINGERS. (Also includes a schedule of parts.) American Bridge Company, Ambridge Plant No. 5, sheet no. 2, dated April 2, 1928 (revised 4-24-28), order no. F5073. For U.S. Steel Products Company, Pacific Coast Depot, order no. SF578. For Southern Pacific Company, order no. 8873-P-28746. Scale 1/4 inch to one foot. - Napa River Railroad Bridge, Spanning Napa River, east of Soscol Avenue, Napa, Napa County, CA

  10. Electrolytes including fluorinated solvents for use in electrochemical cells

    DOEpatents

    Tikhonov, Konstantin; Yip, Ka Ki; Lin, Tzu-Yuan

    2015-07-07

    Provided are electrochemical cells and electrolytes used to build such cells. The electrolytes include ion-supplying salts and fluorinated solvents capable of maintaining single phase solutions with the salts at between about -30.degree. C. to about 80.degree. C. The fluorinated solvents, such as fluorinated carbonates, fluorinated esters, and fluorinated esters, are less flammable than their non-fluorinated counterparts and increase safety characteristics of cells containing these solvents. The amount of fluorinated solvents in electrolytes may be between about 30% and 80% by weight not accounting weight of the salts. Fluorinated salts, such as fluoroalkyl-substituted LiPF.sub.6, fluoroalkyl-substituted LiBF.sub.4 salts, linear and cyclic imide salts as well as methide salts including fluorinated alkyl groups, may be used due to their solubility in the fluorinated solvents. In some embodiments, the electrolyte may also include a flame retardant, such as a phosphazene or, more specifically, a cyclic phosphazene and/or one or more ionic liquids.

  11. Modeling heart rate variability including the effect of sleep stages.

    PubMed

    Soliński, Mateusz; Gierałtowski, Jan; Żebrowski, Jan

    2016-02-01

    We propose a model for heart rate variability (HRV) of a healthy individual during sleep with the assumption that the heart rate variability is predominantly a random process. Autonomic nervous system activity has different properties during different sleep stages, and this affects many physiological systems including the cardiovascular system. Different properties of HRV can be observed during each particular sleep stage. We believe that taking into account the sleep architecture is crucial for modeling the human nighttime HRV. The stochastic model of HRV introduced by Kantelhardt et al. was used as the initial starting point. We studied the statistical properties of sleep in healthy adults, analyzing 30 polysomnographic recordings, which provided realistic information about sleep architecture. Next, we generated synthetic hypnograms and included them in the modeling of nighttime RR interval series. The results of standard HRV linear analysis and of nonlinear analysis (Shannon entropy, Poincaré plots, and multiscale multifractal analysis) show that-in comparison with real data-the HRV signals obtained from our model have very similar properties, in particular including the multifractal characteristics at different time scales. The model described in this paper is discussed in the context of normal sleep. However, its construction is such that it should allow to model heart rate variability in sleep disorders. This possibility is briefly discussed.

  12. Multi-processor including data flow accelerator module

    DOEpatents

    Davidson, George S.; Pierce, Paul E.

    1990-01-01

    An accelerator module for a data flow computer includes an intelligent memory. The module is added to a multiprocessor arrangement and uses a shared tagged memory architecture in the data flow computer. The intelligent memory module assigns locations for holding data values in correspondence with arcs leading to a node in a data dependency graph. Each primitive computation is associated with a corresponding memory cell, including a number of slots for operands needed to execute a primitive computation, a primitive identifying pointer, and linking slots for distributing the result of the cell computation to other cells requiring that result as an operand. Circuitry is provided for utilizing tag bits to determine automatically when all operands required by a processor are available and for scheduling the primitive for execution in a queue. Each memory cell of the module may be associated with any of the primitives, and the particular primitive to be executed by the processor associated with the cell is identified by providing an index, such as the cell number for the primitive, to the primitive lookup table of starting addresses. The module thus serves to perform functions previously performed by a number of sections of data flow architectures and coexists with conventional shared memory therein. A multiprocessing system including the module operates in a hybrid mode, wherein the same processing modules are used to perform some processing in a sequential mode, under immediate control of an operating system, while performing other processing in a data flow mode.

  13. Conversion of geothermal waste to commercial products including silica

    DOEpatents

    Premuzic, Eugene T.; Lin, Mow S.

    2003-01-01

    A process for the treatment of geothermal residue includes contacting the pigmented amorphous silica-containing component with a depigmenting reagent one or more times to depigment the silica and produce a mixture containing depigmented amorphous silica and depigmenting reagent containing pigment material; separating the depigmented amorphous silica and from the depigmenting reagent to yield depigmented amorphous silica. Before or after the depigmenting contacting, the geothermal residue or depigmented silica can be treated with a metal solubilizing agent to produce another mixture containing pigmented or unpigmented amorphous silica-containing component and a solubilized metal-containing component; separating these components from each other to produce an amorphous silica product substantially devoid of metals and at least partially devoid of pigment. The amorphous silica product can be neutralized and thereafter dried at a temperature from about 25.degree. C. to 300.degree. C. The morphology of the silica product can be varied through the process conditions including sequence contacting steps, pH of depigmenting reagent, neutralization and drying conditions to tailor the amorphous silica for commercial use in products including filler for paint, paper, rubber and polymers, and chromatographic material.

  14. Transport Phenomena in Thin Rotating Liquid Films Including: Nucleate Boiling

    NASA Technical Reports Server (NTRS)

    Faghri, Amir

    2005-01-01

    In this grant, experimental, numerical and analytical studies of heat transfer in a thin liquid film flowing over a rotating disk have been conducted. Heat transfer coefficients were measured experimentally in a rotating disk heat transfer apparatus where the disk was heated from below with electrical resistance heaters. The heat transfer measurements were supplemented by experimental characterization of the liquid film thickness using a novel laser based technique. The heat transfer measurements show that the disk rotation plays an important role on enhancement of heat transfer primarily through the thinning of the liquid film. Experiments covered both momentum and rotation dominated regimes of the flow and heat transfer in this apparatus. Heat transfer measurements have been extended to include evaporation and nucleate boiling and these experiments are continuing in our laboratory. Empirical correlations have also been developed to provide useful information for design of compact high efficiency heat transfer devices. The experimental work has been supplemented by numerical and analytical analyses of the same problem. Both numerical and analytical results have been found to agree reasonably well with the experimental results on liquid film thickness and heat transfer Coefficients/Nusselt numbers. The numerical simulations include the free surface liquid film flow and heat transfer under disk rotation including the conjugate effects. The analytical analysis utilizes an integral boundary layer approach from which

  15. Modeling heart rate variability including the effect of sleep stages

    NASA Astrophysics Data System (ADS)

    Soliński, Mateusz; Gierałtowski, Jan; Żebrowski, Jan

    2016-02-01

    We propose a model for heart rate variability (HRV) of a healthy individual during sleep with the assumption that the heart rate variability is predominantly a random process. Autonomic nervous system activity has different properties during different sleep stages, and this affects many physiological systems including the cardiovascular system. Different properties of HRV can be observed during each particular sleep stage. We believe that taking into account the sleep architecture is crucial for modeling the human nighttime HRV. The stochastic model of HRV introduced by Kantelhardt et al. was used as the initial starting point. We studied the statistical properties of sleep in healthy adults, analyzing 30 polysomnographic recordings, which provided realistic information about sleep architecture. Next, we generated synthetic hypnograms and included them in the modeling of nighttime RR interval series. The results of standard HRV linear analysis and of nonlinear analysis (Shannon entropy, Poincaré plots, and multiscale multifractal analysis) show that—in comparison with real data—the HRV signals obtained from our model have very similar properties, in particular including the multifractal characteristics at different time scales. The model described in this paper is discussed in the context of normal sleep. However, its construction is such that it should allow to model heart rate variability in sleep disorders. This possibility is briefly discussed.

  16. Upcoming treatments in Parkinson's disease, including gene therapy.

    PubMed

    Rodnitzky, Robert L

    2012-01-01

    Progress is being made in the development of three categories of therapy for Parkinson's disease: (1) Symptomatic, (2) Neuroprotective, (3) Neurorestorative. Evolving approaches to symptomatic therapy, already in clinical trials, include the use of adenosine 2(A) antagonists, novel glutamate antagonists, and serotonin receptor antagonists, the latter for the therapy of Parkinson's psychosis and/or levodopa-induced dyskinesias. Examples of promising neuroprotective therapies under evaluation include the administration of creatine, urate-inducing compounds, calcium channel blockers, and pioglitazone, a peroxisome proliferator-activated receptor agonist. Cell-based restorative therapies are not the subject of this presentation, but various forms of gene therapy have shown promise in human Parkinson's disease trials. These protocols typically involve gene transfer into the CNS through the use of viral vectors. Currently, the most advanced studies of this technique involve delivery of an adeno-associated viral vector encoding glutamic acid decarboxylase into the subthalamic nucleus. This treatment has shown modest benefit in early clinical trials. Other gene therapies, in various stages of human clinical trials, include gene transfer for the production of trophic factors, for aromatic amino acid decarboxylase alone, and most recently, a lentiviral vector transfer of an enzymatic dopamine "factory" consisting of three essential enzymes required for production for this neurotransmitter.

  17. 77 FR 9969 - Clow Water Systems Company Including On-Site Leased Workers From Carol Harris Stafffing Including...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... Harris Stafffing Including Workers Whose Unemployment Insurance (UI) Wages Are Reported Through McWane... Clow Water Systems Company had their wages reported through a separate unemployment insurance (UI) tax... workers of the subject firm whose unemployment insurance (UI) wages are reported through McWane, Inc....

  18. United States/Mexico electricity trade study. [Glossary included

    SciTech Connect

    Not Available

    1991-03-01

    During energy discussions between the United States and Mexico, it was suggested that the two countries revisit the issue of enhanced electricity trade because 10 years had elapsed since this issue was first studied. Responsibility to organize the updated study was jointly assigned to the US and to the Comision Federal de Electricidad (CFE). The study highlights the opportunities for increased cooperation among the electric utilities in the U.S. and Mexico. Direct benefits could include increased reliability of electric power service and cost savings through diversity of peak demand patterns and locational benefits associated with the siting of new generation sources. Indirect benefits could include improved economic and employment opportunities, especially in the border areas of both countries. While the study indicates that increased electricity trade is possible, there are significant technical and economic issues to consider. Any major increase in electricity trade would require a higher level of cooperation and coordination among utilities in both countries and would need to be preceded by a detailed analysis of associated benefits and costs (including environmental impacts) on both a short-term and a long-term basis. Whether US utilities and CFE decide to pursue specific projects will depend upon the need for and economics of those projects. The study recommends that the work begun by the two utility groups be continued. The study also recommends that regulators at all levels consider policies to increase coordination and review among all relevant parties so that unnecessary delays in planning and constructing needed facilities are avoided. 12 figs., 17 tabs.

  19. Monte Carlo modeling of cometary atmospheres including polarization

    NASA Astrophysics Data System (ADS)

    Moreno, F.; Muñoz, O.; Molina, A.

    We present a Monte Carlo model for the transfer of radiation by dust in spherical-shell cometary atmospheres. Our model, which includes the effects of polarization, constitutes an improved version of that by Salo cite{bib31}. The code has been designed to compute both the input radiation on the nucleus surface and the output radiation. This has specific applications regarding the interpretation of near-nucleus photometry, polarimetry, and imaging such as planned for the near future space probes. After showing the appropriate validations of the code with other modeling results, we address here the effect of including the full 4 times 4 scattering matrix into the calculations of the radiative flux impinging on cometary nuclei. As input of the code we use realistic single scattering phase matrices derived by fitting the observed behavior of the linear polarization versus phase angle in cometary atmospheres. The observed single scattering linear polarization phase curves of comets are found to be fairly well represented by a mixture of Mg-rich olivine particles and small carbonaceous particles. The input matrix of the code is thus given by the phase matrix for olivine as obtained in the laboratory cite{bib27} plus a variable scattering fraction phase matrix for absorbing carbonaceous particles. Particularly, these fractions are found to be 3.5% for comet Halley and 6% for comet Hale-Bopp, for which the greatest percentage of all the observed comets was found. The total input fluxes computed by ignoring the polarization effects are found to show differences as large as 10% with respect to the fluxes obtained when the full scattering matrix is included in the calculations.

  20. Composite material including nanocrystals and methods of making

    DOEpatents

    Bawendi, Moungi G.; Sundar, Vikram C.

    2008-02-05

    Temperature-sensing compositions can include an inorganic material, such as a semiconductor nanocrystal. The nanocrystal can be a dependable and accurate indicator of temperature. The intensity of emission of the nanocrystal varies with temperature and can be highly sensitive to surface temperature. The nanocrystals can be processed with a binder to form a matrix, which can be varied by altering the chemical nature of the surface of the nanocrystal. A nanocrystal with a compatibilizing outer layer can be incorporated into a coating formulation and retain its temperature sensitive emissive properties

  1. Harmonic measure for percolation and ising clusters including rare events.

    PubMed

    Adams, David A; Sander, Leonard M; Ziff, Robert M

    2008-10-03

    We obtain the harmonic measure of the hulls of critical percolation clusters and Ising-model Fortuin-Kastelyn clusters using a biased random-walk sampling technique which allows us to measure probabilities as small as 10{-300}. We find the multifractal D(q) spectrum including regions of small and negative q. Our results for external hulls agree with Duplantier's theoretical predictions for D(q) and his exponent -23/24 for the harmonic measure probability distribution for percolation. For the complete hull, we find the probability decays with an exponent of -1 for both systems.

  2. The need to include animal protection in public health policies.

    PubMed

    Akhtar, Aysha

    2013-11-01

    Many critical public health issues require non-traditional approaches. Although many novel strategies are used, one approach not widely applied involves improving the treatment of animals. Emerging infectious diseases are pressing public health challenges that could benefit from improving the treatment of animals. Other human health issues, that overlap with animal treatment issues, and that warrant further exploration, are medical research and domestic violence. The diverse nature of these health issues and their connection with animal treatment suggest that there may be other similar intersections. Public health would benefit by including the treatment of animals as a topic of study and policy development.

  3. Characteristics of Six Propellers Including the High-Speed Range

    NASA Technical Reports Server (NTRS)

    Theodorsen, Theodore; Stickle, George W; Brevoort, M J

    1937-01-01

    This investigation is part of an extensive experimental study that has been carried out at full scale in the NACA 20-foot tunnel, the purpose of which has been to furnish information in regard to the functioning of the propeller-cowling-nacelle unit under all conditions of take-off, climbing, and normal flight. This report presents the results of tests of six propellers in the normal and high-speed flight range and also includes a study of the take-off characteristics.

  4. Effect of environmental pollutants on human reproduction, including birth defects

    SciTech Connect

    Kurzel, R.B.; Cetrulo, C.L.

    1981-06-01

    Because chemicals from a wide range of environmental sources have been implicated in birth defects and reproductive failures, the effects on human reproduction of chemicals in air, in the terrestrial ecosystem, and in food were studied. Chemicals considered included nicotine, cadmium, polycyclic aromatic compounds, red dye number2, DES, PCB's, TCDD, mercury, molybdenum, nickel, selenium, strontium, and zinc. The most serious source of chemical exposure to pregnant women is cigarette smoke which exposes unborn babies to high levels of carbon monoxide, cadmium, nicotine, and benzo-a-pyrene. Fetal exposure to all teratogenic compounds must be minimized.

  5. Composite material including nanocrystals and methods of making

    DOEpatents

    Bawendi, Moungi G.; Sundar, Vikram C.

    2010-04-06

    Temperature-sensing compositions can include an inorganic material, such as a semiconductor nanocrystal. The nanocrystal can be a dependable and accurate indicator of temperature. The intensity of emission of the nanocrystal varies with temperature and can be highly sensitive to surface temperature. The nanocrystals can be processed with a binder to form a matrix, which can be varied by altering the chemical nature of the surface of the nanocrystal. A nanocrystal with a compatibilizing outer layer can be incorporated into a coating formulation and retain its temperature sensitive emissive properties.

  6. Composite armor, armor system and vehicle including armor system

    DOEpatents

    Chu, Henry S.; Jones, Warren F.; Lacy, Jeffrey M.; Thinnes, Gary L.

    2013-01-01

    Composite armor panels are disclosed. Each panel comprises a plurality of functional layers comprising at least an outermost layer, an intermediate layer and a base layer. An armor system incorporating armor panels is also disclosed. Armor panels are mounted on carriages movably secured to adjacent rails of a rail system. Each panel may be moved on its associated rail and into partially overlapping relationship with another panel on an adjacent rail for protection against incoming ordnance from various directions. The rail system may be configured as at least a part of a ring, and be disposed about a hatch on a vehicle. Vehicles including an armor system are also disclosed.

  7. Cont-Bouchaud Percolation Model Including Tobin Tax

    NASA Astrophysics Data System (ADS)

    Ehrenstein, Gudrun

    The Tobin tax is an often discussed method to tame speculation and get a source of income. The discussion is especially heated when the financial markets are in crisis. In this article we refer to the foreign exchange markets. The Tobin tax should be a small international tax affecting all currency transactions and thus consequently reducing destabilizing speculations. In this way this tax should take over a control function. By including the Tobin tax in the microscopic model of Cont and Bouchaud one finds that this tax could be the right method to control foreign exchange operations and to get a good source of income.

  8. Next-Generation Technologies for Multiomics Approaches Including Interactome Sequencing

    PubMed Central

    Ohashi, Hiroyuki; Miyamoto-Sato, Etsuko

    2015-01-01

    The development of high-speed analytical techniques such as next-generation sequencing and microarrays allows high-throughput analysis of biological information at a low cost. These techniques contribute to medical and bioscience advancements and provide new avenues for scientific research. Here, we outline a variety of new innovative techniques and discuss their use in omics research (e.g., genomics, transcriptomics, metabolomics, proteomics, and interactomics). We also discuss the possible applications of these methods, including an interactome sequencing technology that we developed, in future medical and life science research. PMID:25649523

  9. Computation of eigenfrequencies for equilibrium models including turbulent pressure

    NASA Astrophysics Data System (ADS)

    Sonoi, T.; Belkacem, K.; Dupret, M.-A.; Samadi, R.; Ludwig, H.-G.; Caffau, E.; Mosser, B.

    2017-03-01

    Context. The space-borne missions CoRoT and Kepler have provided a wealth of highly accurate data. However, our inability to properly model the upper-most region of solar-like stars prevents us from making the best of these observations. This problem is called "surface effect" and a key ingredient to solve it is turbulent pressure for the computation of both the equilibrium models and the oscillations. While 3D hydrodynamic simulations help to include properly the turbulent pressure in the equilibrium models, the way this surface effect is included in the computation of stellar oscillations is still subject to uncertainties. Aims: We aim at determining how to properly include the effect of turbulent pressure and its Lagrangian perturbation in the adiabatic computation of the oscillations. We also discuss the validity of the gas-gamma model and reduced gamma model approximations, which have been used to compute adiabatic oscillations of equilibrium models including turbulent pressure. Methods: We use a patched model of the Sun with an inner part constructed by a 1D stellar evolution code (CESTAM) and an outer part by the 3D hydrodynamical code (CO5BOLD). Then, the adiabatic oscillations are computed using the ADIPLS code for the gas-gamma and reduced gamma model approximations and with the MAD code imposing the adiabatic condition on an existing time-dependent convection formalism. Finally, all those results are compared to the observed solar frequencies. Results: We show that the computation of the oscillations using the time-dependent convection formalism in the adiabatic limit improves significantly the agreement with the observed frequencies compared to the gas-gamma and reduced gamma model approximations. Of the components of the perturbation of the turbulent pressure, the perturbation of the density and advection term is found to contribute most to the frequency shift. Conclusions: The turbulent pressure is certainly the dominant factor responsible for the

  10. cDNA encoding a polypeptide including a hevein sequence

    DOEpatents

    Raikhel, Natasha V.; Broekaert, Willem F.; Chua, Nam-Hai; Kush, Anil

    1993-02-16

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a pu GOVERNMENT RIGHTS This application was funded under Department of Energy Contract DE-AC02-76ER01338. The U.S. Government has certain rights under this application and any patent issuing thereon.

  11. Including auroral oval boundaries in the IRI model

    NASA Technical Reports Server (NTRS)

    Bilitza, A.

    1995-01-01

    At the last International Reference Ionosphere (IRI) Workshop it was decided that future editions of the model should include a representationof the aurroral oval boundaries. In this paper we review the different existing parameterizations of the auroral oval discussing their data base, boundary criteria, matematical formation, and overall usefulness for IRI. As a first candidate for incorporation into IRI we recomment the parameterization of the Feldstein ovals by Holzworth and Meng. Ways of implementing this model into IRI are discussed. We will also address adjustability with user-provided boundaries or boundary-related parameters, to better support strom-related studies.

  12. Supersonic flow past oscillating airfoils including nonlinear thickness effects

    NASA Technical Reports Server (NTRS)

    Van Dyke, Milton D

    1954-01-01

    A solution to second order in thickness is derived for harmonically oscillating two-dimensional airfoils in supersonic flow. For slow oscillations of an arbitrary profile, the result is found as a series including the third power of frequency. For arbitrary frequencies, the method of solution for any specific profile is indicated, and the explicit solution derived for a single wedge. Nonlinear thickness effects are found generally to reduce the torsional damping, and so enlarge the range of Mach numbers within which torsional instability is possible.

  13. The need to include animal protection in public health policies

    PubMed Central

    Akhtar, Aysha

    2013-01-01

    Many critical public health issues require non-traditional approaches. Although many novel strategies are used, one approach not widely applied involves improving the treatment of animals. Emerging infectious diseases are pressing public health challenges that could benefit from improving the treatment of animals. Other human health issues, that overlap with animal treatment issues, and that warrant further exploration, are medical research and domestic violence. The diverse nature of these health issues and their connection with animal treatment suggest that there may be other similar intersections. Public health would benefit by including the treatment of animals as a topic of study and policy development. PMID:23803712

  14. Numerical optimization of conical flow waveriders including detailed viscous effects

    NASA Technical Reports Server (NTRS)

    Bowcutt, Kevin G.; Anderson, John D., Jr.; Capriotti, Diego

    1987-01-01

    A family of optimized hypersonic waveriders is generated and studied wherein detailed viscous effects are included within the optimization process itself. This is in contrast to previous optimized waverider work, wherein purely inviscid flow is used to obtain the waverider shapes. For the present waveriders, the undersurface is a streamsurface of an inviscid conical flowfield, the upper surface is a streamsurface of the inviscid flow over a tapered cylinder (calculated by the axisymmetric method of characteristics), and the viscous effects are treated by integral solutions of the boundary layer equations. Transition from laminar to turbulent flow is included within the viscous calculations. The optimization is carried out using a nonlinear simplex method. The resulting family of viscous hypersonic waveriders yields predicted high values of lift/drag, high enough to break the L/D barrier based on experience with other hypersonic configurations. Moreover, the numerical optimization process for the viscous waveriders results in distinctly different shapes compared to previous work with inviscid-designed waveriders. Also, the fine details of the viscous solution, such as how the shear stress is distributed over the surface, and the location of transition, are crucial to the details of the resulting waverider geometry. Finally, the moment coefficient variations and heat transfer distributions associated with the viscous optimized waveriders are studied.

  15. Community Assessment Tool for Public Health Emergencies Including Pandemic Influenza

    SciTech Connect

    ORAU's Oak Ridge Institute for Science Education

    2011-04-14

    The Community Assessment Tool (CAT) for Public Health Emergencies Including Pandemic Influenza (hereafter referred to as the CAT) was developed as a result of feedback received from several communities. These communities participated in workshops focused on influenza pandemic planning and response. The 2008 through 2011 workshops were sponsored by the Centers for Disease Control and Prevention (CDC). Feedback during those workshops indicated the need for a tool that a community can use to assess its readiness for a disaster - readiness from a total healthcare perspective, not just hospitals, but the whole healthcare system. The CAT intends to do just that - help strengthen existing preparedness plans by allowing the healthcare system and other agencies to work together during an influenza pandemic. It helps reveal each core agency partners (sectors) capabilities and resources, and highlights cases of the same vendors being used for resource supplies (e.g., personal protective equipment [PPE] and oxygen) by the partners (e.g., public health departments, clinics, or hospitals). The CAT also addresses gaps in the community's capabilities or potential shortages in resources. This tool has been reviewed by a variety of key subject matter experts from federal, state, and local agencies and organizations. It also has been piloted with various communities that consist of different population sizes, to include large urban to small rural communities.

  16. Magnetic properties of nickel halide hydrates including deuteration effects

    NASA Astrophysics Data System (ADS)

    DeFotis, G. C.; Van Dongen, M. J.; Hampton, A. S.; Komatsu, C. H.; Trowell, K. T.; Havas, K. C.; Davis, C. M.; DeSanto, C. L.; Hays, K.; Wagner, M. J.

    2017-01-01

    Magnetic measurements on variously hydrated nickel chlorides and bromides, including deuterated forms, are reported. Results include locations and sizes of susceptibility maxima, Tmax and χmax, ordering temperatures Tc, Curie constants and Weiss theta in the paramagnetic regime, and primary and secondary exchange interactions from analysis of low temperature data. For the latter a 2D Heisenberg model augmented by interlayer exchange in a mean-field approximation is applied. Magnetization data to 16 kG as a function of temperature show curvature and hysteresis characteristics quite system dependent. For four materials high field magnetization data to 70 kG at 2.00 K are also obtained. Comparison is made with theoretical relations for spin-1 models. Trends are apparent, primarily that Tmax of each bromide hydrate is less than for the corresponding chloride, and that for a given halide nD2O (n=1 or 2) deuterates exhibit lesser Tmax than do nH2O hydrates. A monoclinic unit cell determined from powder X-ray diffraction data on NiBr2·2D2O is different from and slightly larger than that of NiBr2·2H2O. This provides some rationale for the difference in magnetic properties between these.

  17. Confidence in climate models including those with suspended particles

    NASA Astrophysics Data System (ADS)

    Reck, Ruth A.

    1982-05-01

    Confidence in the predictions of atmospheric models is limited, (1) by the uncertainty in our knowledge of the existing atmospheric system as it is defined by input data, and (2) by the ability of the model to describe all pertinent atmospheric processes. This paper describes a thermal sensitivity study of the global parameters in one version of the Manabe-Wetherald radiative-convective model which inclkudes Mie scattering particles. The relative importance of the usual global model parameters is identified in addition to other atmospheric constituents not commonly included in climate models. In particular this work emphasizes the role of Mie scattering suspended aerosol particles, a component which is seldom included in climate models. Here we discuss the major sources of particles, how the optical properties of individual particles determine the radiative effects of a particle layer, and also illustrate the separate role of absorption and backscatter in determining the sign of the surface temperature change. In addition, the coupling of the particle effects to surface albedo is indicated. Finally, the sign of the surface temperature change from anthropogenic particles is estimated using (1) global maps of particle abundance developed by Kellogg, (2) previous calculations for the Northern Hemisphere published by the author and (3) the surface albedo maps of Hummel and Reck.

  18. Remote Observations of Reentering Spacecraft Including the Space Shuttle Orbiter

    NASA Technical Reports Server (NTRS)

    Horvath, Thomas J.; Cagle, Melinda F.; Grinstead, jay H.; Gibson, David

    2013-01-01

    Flight measurement is a critical phase in development, validation and certification processes of technologies destined for future civilian and military operational capabilities. This paper focuses on several recent NASA-sponsored remote observations that have provided unique engineering and scientific insights of reentry vehicle flight phenomenology and performance that could not necessarily be obtained with more traditional instrumentation methods such as onboard discrete surface sensors. The missions highlighted include multiple spatially-resolved infrared observations of the NASA Space Shuttle Orbiter during hypersonic reentry from 2009 to 2011, and emission spectroscopy of comparatively small-sized sample return capsules returning from exploration missions. Emphasis has been placed upon identifying the challenges associated with these remote sensing missions with focus on end-to-end aspects that include the initial science objective, selection of the appropriate imaging platform and instrumentation suite, target flight path analysis and acquisition strategy, pre-mission simulations to optimize sensor configuration, logistics and communications during the actual observation. Explored are collaborative opportunities and technology investments required to develop a next-generation quantitative imaging system (i.e., an intelligent sensor and platform) with greater capability, which could more affordably support cross cutting civilian and military flight test needs.

  19. A Mixed Mode Cochlear Amplifier Including Neural Feedback

    NASA Astrophysics Data System (ADS)

    Flax, Matthew R.; Holmes, W. Harvey

    2011-11-01

    The mixed mode cochlear amplifier (MMCA) model is derived from the physiology of the cochlea. It is comprised of three main elements of the peripheral hearing system: the cochlear mechanics, hair cell motility, and neurophysiology. This model expresses both active compression wave and active traveling wave modes of operation. The inclusion of a neural loop with a time delay, and a new paradigm for the mechanical response of the outer hair cells, are believed to be unique features of the MMCA. These elements combine to form an active feedback loop to constitute the cochlear amplifier, whose input is a passive traveling wave vibration. The result is a cycle-by-cycle amplifier with nonlinear response. This system can assume an infinite number of different operating states. The stable state and the first few amplitude-limited unstable (Hopf-bifurcated) states are significant in describing the operation of the peripheral hearing system. A hierarchy of models can be constructed from this concept, depending on the amount of detail included. The simplest model of the MMCA is a nonlinear delay line resonator. It was found that even this simple MMCA version can explain a large number of hearing phenomena, at least qualitatively. This paper concentrates on explaining the fractional octave shift from the living to postmortem response in terms of the new model. Other mechanical, hair cell and neurological phenomena can also be accounted for by the MMCA, including two-tone suppression behavior, distortion product responses, otoacoustic emissions and neural spontaneous rates.

  20. Remote observations of reentering spacecraft including the space shuttle orbiter

    NASA Astrophysics Data System (ADS)

    Horvath, Thomas J.; Cagle, Melinda F.; Grinstead, Jay H.; Gibson, David M.

    Flight measurement is a critical phase in development, validation and certification processes of technologies destined for future civilian and military operational capabilities. This paper focuses on several recent NASA-sponsored remote observations that have provided unique engineering and scientific insights of reentry vehicle flight phenomenology and performance that could not necessarily be obtained with more traditional instrumentation methods such as onboard discrete surface sensors. The missions highlighted include multiple spatially-resolved infrared observations of the NASA Space Shuttle Orbiter during hypersonic reentry from 2009 to 2011, and emission spectroscopy of comparatively small-sized sample return capsules returning from exploration missions. Emphasis has been placed upon identifying the challenges associated with these remote sensing missions with focus on end-to-end aspects that include the initial science objective, selection of the appropriate imaging platform and instrumentation suite, target flight path analysis and acquisition strategy, pre-mission simulations to optimize sensor configuration, logistics and communications during the actual observation. Explored are collaborative opportunities and technology investments required to develop a next-generation quantitative imaging system (i.e., an intelligent sensor and platform) with greater capability, which could more affordably support cross cutting civilian and military flight test needs.

  1. Photodissociation dynamics of phenol: multistate trajectory simulations including tunneling.

    PubMed

    Xu, Xuefei; Zheng, Jingjing; Yang, Ke R; Truhlar, Donald G

    2014-11-19

    We report multistate trajectory simulations, including coherence, decoherence, and multidimensional tunneling, of phenol photodissociation dynamics. The calculations are based on full-dimensional anchor-points reactive potential surfaces and state couplings fit to electronic structure calculations including dynamical correlation with an augmented correlation-consistent polarized valence double-ζ basis set. The calculations successfully reproduce the experimentally observed bimodal character of the total kinetic energy release spectra and confirm the interpretation of the most recent experiments that the photodissociation process is dominated by tunneling. Analysis of the trajectories uncovers an unexpected dissociation pathway for one quantum excitation of the O-H stretching mode of the S1 state, namely, tunneling in a coherent mixture of states starting in a smaller ROH (∼0.9-1.0 Å) region than has previously been invoked. The simulations also show that most trajectories do not pass close to the S1-S2 conical intersection (they have a minimum gap greater than 0.6 eV), they provide statistics on the out-of-plane angles at the locations of the minimum energy adiabatic gap, and they reveal information about which vibrational modes are most highly activated in the products.

  2. Optical properties of dielectric thin films including quantum dots

    NASA Astrophysics Data System (ADS)

    Flory, F.; Chen, Y. J.; Lee, C. C.; Escoubas, L.; Simon, J. J.; Torchio, P.; Le Rouzo, J.; Vedraine, S.; Derbal-Habak, Hassina; Ackermann, Jorg; Shupyk, Ivan; Didane, Yahia

    2010-08-01

    Depending on the minimum size of their micro/nano structure, thin films can exhibit very different behaviors and optical properties. From optical waveguides down to artificial anisotropy, through diffractive optics and photonic crystals, the application changes when decreasing the minimum feature size. Rigorous electromagnetic theory can be used to model most of the components but when the size is of a few nanometers, quantum theory has also to be used. These materials including quantum structures are of particular interest for other applications, in particular for solar cells, because of their luminescent and electronic properties. We show that the properties of electrons in multiple quantum wells can be easily modeled with a formalism similar to that used for multilayer waveguides. The effects of different parameters, in particular coupling between wells and well thickness dispersion, on possible discrete energy levels or energy band of electrons and on electron wave functions is given. When such quantum confinement appears the spectral absorption and the extinction coefficient dispersion with wavelength is modified. The dispersion of the real part of the refractive index can then be deduced from the Kramers- Krönig relations. Associated with homogenization theory this approach gives a new model of refractive index for thin films including quantum dots. Absorption spectra of samples composed of ZnO quantum dots in PMMA layers are in preparation are given.

  3. Constant-Pressure Combustion Charts Including Effects of Diluent Addition

    NASA Technical Reports Server (NTRS)

    Turner, L Richard; Bogart, Donald

    1949-01-01

    Charts are presented for the calculation of (a) the final temperatures and the temperature changes involved in constant-pressure combustion processes of air and in products of combustion of air and hydrocarbon fuels, and (b) the quantity of hydrocarbon fuels required in order to attain a specified combustion temperature when water, alcohol, water-alcohol mixtures, liquid ammonia, liquid carbon dioxide, liquid nitrogen, liquid oxygen, or their mixtures are added to air as diluents or refrigerants. The ideal combustion process and combustion with incomplete heat release from the primary fuel and from combustible diluents are considered. The effect of preheating the mixture of air and diluents and the effect of an initial water-vapor content in the combustion air on the required fuel quantity are also included. The charts are applicable only to processes in which the final mixture is leaner than stoichiometric and at temperatures where dissociation is unimportant. A chart is also included to permit the calculation of the stoichiometric ratio of hydrocarbon fuel to air with diluent addition. The use of the charts is illustrated by numerical examples.

  4. Cogeneration handbook for the textile industry. [Includes glossary

    SciTech Connect

    Not Available

    1984-02-01

    The US Department of Energy (DOE) contracted with Pacific Northwest Laboratory (PNL) to provide the textile plant manager or company energy coordinator with a framework for making a preliminary assessment of the feasibility and viability of cogeneration at a particular plant. The handbook is intended to provide an understanding of the potential of several standardized cogeneration systems, as well as their limitations. However, because the deicision to cogenerate is very site specific, the handbook cannot provide all of the answers. It does attempt, however, to bring to light the major issues that should be addressed in the decision-making process. The decision of whether to cogenerate involves several considerations, including technical, economic, environmental, legal, and regulatory issues. Each of these issues is addressed separately in this handbook. In addition, a chapter is included on preparing a three-phase work statement, which is needed to guide the design of a cogeneration system. Experience has shown that a well-defined work statement can be the key to a rapid and cost-effective design effort. Discussion is presented under the headings: Data Base Development; Matching Cogeneration System Designs; Economic Analysis; Financial Strategies; Environmental Issues; Legal and Contractual Issues; and Three-Phase Work Statements. 18 references, 36 figures, 30 tables.

  5. Radiometric sensor performance model including atmospheric and IR clutter effects

    NASA Astrophysics Data System (ADS)

    Richter, Rudolf; Davis, Joel S.; Duggin, Michael J.

    1997-06-01

    The computer code SENSAT developed for radiometric investigations in remote sensing was extended to include two statistical clutter models of infrared background and the prediction of the target detection probability. The first one is based on the standard deviation of scene clutter estimated from scene data, the second one is based on the power spectral density of different classes of IR background as a function of temporal or spatial frequency. The overall code consists of modules describing the optoelectronic sensor (optics, detector, signal processor), a radiative transfer code (MODTRAN) to include the atmospheric effects, and the scene module consisting of target and background. The scene is evaluated for a certain pixel at a time. However, a sequence of pixels can be simulated by varying the range, view angle, atmospheric condition, or the clutter level. The target consists of one or two subpixel surface elements, the remaining part of the pixels represents background. Multiple paths, e.g. sun-ground-target-sensor, can also be selected. An expert system, based upon the IDL language, provides user-friendly input menus, performs consistency checks, and submits the required MODTRAN and SENSAT runs. A sample case of the detection probability of a sub-pixel target in a marine cluttered background is discussed.

  6. Enhanced simulation of an RF ion funnel including gas turbulence.

    PubMed

    Tridas, Eric; Anthony, J Mark; Guldiken, Rasim; Schlaf, Rudy

    2015-01-01

    Electrodynamic ion funnels are used to enhance the transmission of ions in electrospray-based ion injection systems in 0.1 to 30 Torr pressure range. Jet disrupters are commonly employed to prevent droplets and high pressure jets from entering subsequent vacuum regions. This study presents the simulation and testing of an ion funnel containing a jet disrupter using computational fluid dynamics (CFD) and SIMION ion trajectory simulations. Traditional modeling approaches have utilized approximations for the bulk fluid flow fields without including the time-varying nature of the turbulent flow present in the system, thus yielding idealized results. In this study, the fluid flow fields are calculated using CFD. In an effort to include time dependence, a random velocity vector, whose magnitude is proportional to the square root of the turbulence kinetic energy, was calculated at each time step and added to the velocity of the background gas. These simulations predicted that the transmitted ion current is effectively modulated by the variation of the jet disrupter voltage. The addition of the random velocity vector produced results that closely matched the experiments. The simulations yielded the dependence of the transmission on the jet disrupter voltage, and the voltage necessary for maximum ion throughput was accurately predicted. In addition, the magnitude of the predicted transmission closely matched that of the experimental results. This modeling approach could be extended to similar ion transport and filtering systems in which the effects of turbulent fluid flow cannot be ignored.

  7. Chronic lymphocytic leukemia: a clinical review including Korean cohorts

    PubMed Central

    Jeon, Young-Woo; Cho, Seok-Goo

    2016-01-01

    Only 5th decade ago, chronic lymphocytic leukemia (CLL) was only recognized as disease group of presenting features like peripheral lymphocytosis, organomegaly including of splenomegaly. As understanding of disease biology and molecular diagnostic tools are getting improved gradually, characterization of variation in CLL’s clinical courses was facilitated, resulting in better risk stratification and targeted treatments. Consequently multiple new targeted agents have been used in treatment of CLL, it makes improved clinical outcome. Rituximab containing chemoimmunotherapy (combination of rituximab, fludarabine, and cyclophosphamide) have shown better overall response rate and progression-free survival on fit patients’ group in front-line setting, result in standard first-line therapeutic option for CLL. Furthermore, after introducing that the B-cell receptor is crucial for the evolution and progression of CLL, emerging treatments targeting highly activated surface antigens and oncogenic signaling pathways have been associated with several successes in recent decades. These include new anti-CD 20 monoclonal antibody (obinutuzumab), the bruton tyrosine kinase inhibitor (ibrutinib), the phosphatidylinositol 3-kinase inhibitor (idelalisib), and B-cell CLL/lymphoma 2 inhibitor (ABT-199 and ABT-263). So, we discuss not only general pathophysiology of CLL, but also rapidly advancing treatment strategies that are being studied or approved for treatment of CLL. PMID:27044858

  8. SPICE: Simulation Package for Including Flavor in Collider Events

    NASA Astrophysics Data System (ADS)

    Engelhard, Guy; Feng, Jonathan L.; Galon, Iftah; Sanford, David; Yu, Felix

    2010-01-01

    We describe SPICE: Simulation Package for Including Flavor in Collider Events. SPICE takes as input two ingredients: a standard flavor-conserving supersymmetric spectrum and a set of flavor-violating slepton mass parameters, both of which are specified at some high "mediation" scale. SPICE then combines these two ingredients to form a flavor-violating model, determines the resulting low-energy spectrum and branching ratios, and outputs HERWIG and SUSY Les Houches files, which may be used to generate collider events. The flavor-conserving model may be any of the standard supersymmetric models, including minimal supergravity, minimal gauge-mediated supersymmetry breaking, and anomaly-mediated supersymmetry breaking supplemented by a universal scalar mass. The flavor-violating contributions may be specified in a number of ways, from specifying charges of fields under horizontal symmetries to completely specifying all flavor-violating parameters. SPICE is fully documented and publicly available, and is intended to be a user-friendly aid in the study of flavor at the Large Hadron Collider and other future colliders. Program summaryProgram title: SPICE Catalogue identifier: AEFL_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEFL_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 8153 No. of bytes in distributed program, including test data, etc.: 67 291 Distribution format: tar.gz Programming language: C++ Computer: Personal computer Operating system: Tested on Scientific Linux 4.x Classification: 11.1 External routines: SOFTSUSY [1,2] and SUSYHIT [3] Nature of problem: Simulation programs are required to compare theoretical models in particle physics with present and future data at particle colliders. SPICE determines the masses and decay branching ratios of

  9. Improving Planck calibration by including frequency-dependent relativistic corrections

    SciTech Connect

    Quartin, Miguel; Notari, Alessio E-mail: notari@ffn.ub.es

    2015-09-01

    The Planck satellite detectors are calibrated in the 2015 release using the 'orbital dipole', which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10{sup −3}, due to coupling with the 'solar dipole' (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  10. A Case for Including Transactions in OpenMP

    SciTech Connect

    Wong, M; Bihari, B L; de Supinski, B R; Wu, P; Michael, M; Liu, Y; Chen, W

    2010-01-25

    Transactional Memory (TM) has received significant attention recently as a mechanism to reduce the complexity of shared memory programming. We explore the potential of TM to improve OpenMP applications. We combine a software TM (STM) system to support transactions with an OpenMP implementation to start thread teams and provide task and loop-level parallelization. We apply this system to two application scenarios that reflect realistic TM use cases. Our results with this system demonstrate that even with the relatively high overheads of STM, transactions can outperform OpenMP critical sections by 10%. Overall, our study demonstrates that extending OpenMP to include transactions would ease programming effort while allowing improved performance.

  11. Dye laser amplifier including a specifically designed diffuser assembly

    DOEpatents

    Davin, James; Johnston, James P.

    1992-01-01

    A large (high flow rate) dye laser amplifier in which a continuous replened supply of dye is excited by a first light beam, specifically a copper vapor laser beam, in order to amplify the intensity of a second different light beam, specifically a dye beam, passing through the dye is disclosed herein. This amplifier includes a dye cell defining a dye chamber through which a continuous stream of dye is caused to pass at a relatively high flow rate and a specifically designed diffuser assembly for slowing down the flow of dye while, at the same time, assuring that as the dye stream flows through the diffuser assembly it does so in a stable manner.

  12. Registration efficiency of some SSNTDs with source area included

    NASA Astrophysics Data System (ADS)

    El-Samman, H.; Mansy, M.; Hussein, A.; El-Hawary, M.; El Sersy, A.

    1999-09-01

    In this work, registration efficiency dependence on alpha particle energy and incident angle of some SSNTDs has been studied where the source area ( 241Am thin source) was included in the calculations. Ratio of the number of recorded track density rate ( ρ/ t) to the incident flux ( φ) has been determined using LR-115, CN-85 and CR-39 track detectors etched in the most recommended optimum etching conditions. It was found that the detector registration efficiency is independent on the source-to-detector distance ( d) if the flux is accurately calculated and the point source approximation is worked only for d greater than six times the source diameter when irradiation is performed in air. Results of the present work are discussed within the framework of alpha particle interaction with track detectors where the geometrical configuration of the source and detector arrangement is taken into consideration.

  13. Second floor plan. (Also includes a roof plan and finish ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Second floor plan. (Also includes a roof plan and finish schedule.) March Air Force Base, Riverside, California, Combat Operations Center, Combat Operations Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 13, approved March, 1962; specifications no. OCI-62-66; D.O. series AW 1596/13, Rev. "C"; file drawer 1290. Last revised 7 February 1984. Roof plan scale one-sixteenth inch to one foot; second floor plan scale one-eighth inch to one foot. 28.75x41 inches. pencil on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

  14. Recent progress and advances in iterative software (including parallel aspects)

    SciTech Connect

    Carey, G.; Young, D.M.; Kincaid, D.

    1994-12-31

    The purpose of the workshop is to provide a forum for discussion of the current state of iterative software packages. Of particular interest is software for large scale engineering and scientific applications, especially for distributed parallel systems. However, the authors will also review the state of software development for conventional architectures. This workshop will complement the other proposed workshops on iterative BLAS kernels and applications. The format for the workshop is as follows: To provide some structure, there will be brief presentations, each of less than five minutes duration and dealing with specific facets of the subject. These will be designed to focus the discussion and to stimulate an exchange with the participants. Issues to be covered include: The evolution of iterative packages, current state of the art, the parallel computing challenge, applications viewpoint, standards, and future directions and open problems.

  15. Lunar surface cosmic ray experiment. [including solar flare studies

    NASA Technical Reports Server (NTRS)

    Price, P. B.

    1974-01-01

    The galactic cosmic ray and solar flare experiment on Apollo 16 is reported. The published papers presented describe the experiment, equipment, data processing techniques, and operational history. The principle findings include: (1) The composition of heavy ions in interplanetary space at energies between approximately 30 and 130 MeV/nucleon is the same, within experimental errors. (2) The ability of a Lexan stack to determine simultaneously the energy spectra of major elements from He up to Fe in the energy interval 0.2 to 30 MeV/nucleon revealed systematic changes in the composition of solar flare particles as a function of energy. (3) Heavy ions emitted in a solar flare appear to be completely stripped of electrons, and are not in charge equilibrium at the time of acceleration and releases from the sun.

  16. Pubertal induction in hypogonadism: Current approaches including use of gonadotrophins.

    PubMed

    Zacharin, Margaret

    2015-06-01

    Primary disorders of the gonad or those secondary to abnormalities of the hypothalamic pituitary axis result in hypogonadism. The range of health problems of childhood and adolescence that affect this axis has increased, as most children now survive chronic illness, but many have persisting deficits in gonadal function as a result of their underlying condition or its treatment. An integrated approach to hormone replacement is needed to optimize adult hormonal and bone health, and to offer opportunities for fertility induction and preservation that were not considered possible in the past. Timing of presentation ranges from birth, with disorders of sexual development, through adolescent pubertal failure, to adult fertility problems. This review addresses diagnosis and management of hypogonadism and focuses on new management strategies to address current concerns with fertility preservation. These include Turner syndrome, and fertility presevation prior to childhood cancer treatment. New strategies for male hormone replacement therapy that may impinge upon future fertility are emphasized.

  17. Including the poor: the fiscal impacts of Medicaid expansion.

    PubMed

    Thorpe, K E; Siegel, J E; Dailey, T

    1989-02-17

    This article presents the fiscal impacts of the comprehensive reform of the Medicaid program put forth by the Health Policy Agenda for the American People. Proposed reforms include establishment of improved uniform eligibility standards, improvement in the scope and depth of coverage in state Medicaid programs, and increased provider payment rates. We estimate that expanding Medicaid coverage to all currently uninsured nonelderly persons below the federal poverty line would cost approximately $9 billion. A substantial portion of these costs would offset current spending elsewhere in the health care system. Improvement of state packages and increased provider payment could result in sharp increases in costs. We provide a range of estimates considering both the set of benefits provided and the behavior of the private insurance market.

  18. [Oats can be included in gluten-free diet].

    PubMed

    Hallert, C; Olsson, M; Störsrud, S; Lenner, R A; Kilander, A; Stenhammar, L

    1999-07-28

    In the management of coeliac disease, it has been widely accepted that oats must also be excluded from the diet, along with wheat, rye and barley. The article consists in a review of published reports, and an account of our experience of including oats in the gluten-free diets of adults. Oats were found to be safe and well tolerated by adults with coeliac disease and dermatitis herpetiformis, though the risk of wheat contamination of commercial oat products remains a cause of concern. Similar findings were reported from a study of adolescents, but no such studies have been made of small children. Thus, the inclusion of oats, known to be a fibre-rich, naturally gluten-free food, would broaden the range of foodstuffs tolerable to coeliac patients, though for safety reasons they should be used only by adults until more information is available.

  19. Ball Screw Actuator Including a Compliant Ball Screw Stop

    NASA Technical Reports Server (NTRS)

    Wingett, Paul T. (Inventor); Hanlon, Casey (Inventor)

    2017-01-01

    An actuator includes a ball nut, a ball screw, and a ball screw stop. The ball nut is adapted to receive an input torque and in response rotates and supplies a drive force. The ball screw extends through the ball nut and has a first end and a second end. The ball screw receives the drive force from the ball nut and in response selectively translates between a retract position and a extend position. The ball screw stop is mounted on the ball screw proximate the first end to translate therewith. The ball screw stop engages the ball nut when the ball screw is in the extend position, translates, with compliance, a predetermined distance toward the first end upon engaging the ball nut, and prevents further rotation of the ball screw upon translating the predetermined distance.

  20. Copper laser modulator driving assembly including a magnetic compression laser

    DOEpatents

    Cook, Edward G.; Birx, Daniel L.; Ball, Don G.

    1994-01-01

    A laser modulator (10) having a low voltage assembly (12) with a plurality of low voltage modules (14) with first stage magnetic compression circuits (20) and magnetic assist inductors (28) with a common core (91), such that timing of the first stage magnetic switches (30b) is thereby synchronized. A bipolar second stage of magnetic compression (42) is coupled to the low voltage modules (14) through a bipolar pulse transformer (36) and a third stage of magnetic compression (44) is directly coupled to the second stage of magnetic compression (42). The low voltage assembly (12) includes pressurized boxes (117) for improving voltage standoff between the primary winding assemblies (34) and secondary winding (40) contained therein.

  1. Benefits of including methane measurements in selection strategies.

    PubMed

    Robinson, D L; Oddy, V H

    2016-09-01

    Estimates of genetic/phenotypic covariances and economic values for slaughter weight, growth, feed intake and efficiency, and three potential methane traits were compiled to explore the effect of incorporating methane measurements in breeding objectives for cattle and meat sheep. The cost of methane emissions was assumed to be zero (scenario A), A$476/t (based on A$14/t CO equivalent and methane's 100-yr global warming potential [GWP] of 34; scenario B), or A$2,580/t (A$30/t CO equivalent combined with methane's 20-yr GWP of 86; scenario C). Methane traits were methane yield (MY; methane production divided by feed intake based on measurements over 1 d in respiration chambers) or short-term measurements of methane production adjusted for live weight (MPadjWt) in grazing animals, e.g., 40-60 min measurements in portable accumulation chambers (PAC) on 1 or 3 occasions, or measurements for 1 wk using a GreenFeed Emissions Monitor (GEM) on 1 or 3 occasions. Feed costs included the cost of maintaining the breeding herd and growth from weaning to slaughter. Sheep were assumed to be grown and finished on pasture (A$50/t DM). Feed costs for cattle included 365 d on pasture for the breeding herd and averages of 200 d postweaning grow-out on pasture and 100 d feedlot finishing. The greatest benefit of including methane in the breeding objective for both sheep and cattle was as a proxy for feed intake. For cattle, 3 GEM measurements were estimated to increase profit from 1 round of selection in scenario A (no payment for methane) by A$6.24/animal (from A$20.69 to A$26.93) because of reduced feed costs relative to gains in slaughter weight and by A$7.16 and A$12.09/animal, respectively, for scenarios B and C, which have payments for reduced methane emissions. For sheep, the improvements were more modest. Returns from 1 round of selection (no methane measurements) were A$5.06 (scenario A), A$4.85 (scenario B), and A$3.89 (scenario C) compared to A$5.26 (scenario A), A$5

  2. Standard line broadening impact theory for hydrogen including penetrating collisions

    NASA Astrophysics Data System (ADS)

    Alexiou, S.; Poquérusse, A.

    2005-10-01

    In recent years there has been significant interest in the emission spectra from high-density plasmas, as manifested by a number of experiments. At these high densities short range (small impact parameter) interactions become important and these cannot be adequately handled by the standard theory, whose predictions depend on some cutoffs, necessary to preserve unitarity, the long range approximation, and to ensure the validity of a semiclassical picture. Very recently, as a result of a debate concerning the broadening of isolated ion lines, the importance of penetration of bound electron wave functions by plasma electrons has been realized. By softening the interaction, penetration makes perturbative treatments more valid. The penetration effect has now been included analytically into the standard theory. It turns out that the integrations may be done in closed form in terms of the modified Bessel functions K0 and K1 . This work develops the new theory and applies it to experimental measurements.

  3. Global model including multistep ionizations in helium plasmas

    NASA Astrophysics Data System (ADS)

    Oh, Seung-Ju; Lee, Hyo-Chang; Chung, Chin-Wook

    2016-12-01

    Particle and power balance equations including stepwise ionizations are derived and solved in helium plasmas. In the balance equations, two metastable states (21S1 in singlet and 23S1 triplet) are considered and the followings are obtained. The plasma density linearly increases and the electron temperature is relatively in a constant value against the absorbed power. It is also found that the contribution to multi-step ionization with respect to the single-step ionization is in the range of 8%-23%, as the gas pressure increases from 10 mTorr to 100 mTorr. Compared to the results in the argon plasma, there is little variation in the collisional energy loss per electron-ion pair created (ɛc) with absorbed power and gas pressure due to the small collision cross section and higher inelastic collision threshold energy.

  4. Extending a clinical repository to include multiple sites.

    PubMed Central

    Marrs, K. A.; Kahn, M. G.

    1995-01-01

    With the consolidation of health care organizations and services, a clinical repository comprising data from a single site is no longer sufficient. Individual patient data are now spread across multiple sites comprising a single enterprise. Users require an integrated view, or at least a common view, of these clinical data across multiple sites. Many issues arise when one tries to merge data from multiple, distinct organizations into an existing schema. We have addressed these issues while extending our clinical repository for Barnes Hospital with data from Jewish Hospital, both of which are members of the recently formed BJC Health System. We describe the architecture of our existing repository, approaches and issues in extending this repository to include multiple sites, and the specific issues we addressed in our system. PMID:8563308

  5. Cosmic-Ray Effects of Propagating Shocks Including the Heliosheath

    NASA Astrophysics Data System (ADS)

    Jokipii, J. R.; Kota, J.

    2001-08-01

    It has been known for a long time (Jokipii, et al, 1993) that the e~@ects of tt he heliosphere on cosmic rays extends beyond the termination shock and into the heliosheath. The inclusion of the region beyond the termination shock into models of modulation is still relatively recent. The previously-published model resultshave all been for a stationary system. We have modi~Aed our two-dimensional heliosperic cosmic-ray simulation code to be time dependent and to include a propagating shock wave which propagates out from the Sun and into the Heliosheath. The code follows the time variation of the intensity of both galacticand anomalous cosmic rays as the shock propagates past the point of observation and beyond. The results from the model simulations will be compared with recent observational results suggesting e~@ects of the heliosheath on galacticc and anomalous cosmic rays.

  6. Actuator assembly including a single axis of rotation locking member

    DOEpatents

    Quitmeyer, James N.; Benson, Dwayne M.; Geck, Kellan P.

    2009-12-08

    An actuator assembly including an actuator housing assembly and a single axis of rotation locking member fixedly attached to a portion of the actuator housing assembly and an external mounting structure. The single axis of rotation locking member restricting rotational movement of the actuator housing assembly about at least one axis. The single axis of rotation locking member is coupled at a first end to the actuator housing assembly about a Y axis and at a 90.degree. angle to an X and Z axis providing rotation of the actuator housing assembly about the Y axis. The single axis of rotation locking member is coupled at a second end to a mounting structure, and more particularly a mounting pin, about an X axis and at a 90.degree. angle to a Y and Z axis providing rotation of the actuator housing assembly about the X axis. The actuator assembly is thereby restricted from rotation about the Z axis.

  7. Electra-optical device including a nitrogen containing electrolyte

    DOEpatents

    Bates, J.B.; Dudney, N.J.; Gruzalski, G.R.; Luck, C.F.

    1995-10-03

    Described is a thin-film battery, especially a thin-film microbattery, and a method for making same having application as a backup or primary integrated power source for electronic devices. The battery includes a novel electrolyte which is electrochemically stable and does not react with the lithium anode and a novel vanadium oxide cathode. Configured as a microbattery, the battery can be fabricated directly onto a semiconductor chip, onto the semiconductor die or onto any portion of the chip carrier. The battery can be fabricated to any specified size or shape to meet the requirements of a particular application. The battery is fabricated of solid state materials and is capable of operation between {minus}15 C and 150 C.

  8. Electra-optical device including a nitrogen containing electrolyte

    DOEpatents

    Bates, John B.; Dudney, Nancy J.; Gruzalski, Greg R.; Luck, Christopher F.

    1995-01-01

    Described is a thin-film battery, especially a thin-film microbattery, and a method for making same having application as a backup or primary integrated power source for electronic devices. The battery includes a novel electrolyte which is electrochemically stable and does not react with the lithium anode and a novel vanadium oxide cathode Configured as a microbattery, the battery can be fabricated directly onto a semiconductor chip, onto the semiconductor die or onto any portion of the chip carrier. The battery can be fabricated to any specified size or shape to meet the requirements of a particular application. The battery is fabricated of solid state materials and is capable of operation between -15.degree. C. and 150.degree. C.

  9. Numerical Simulation of Liquid Jet Atomization Including Turbulence Effects

    NASA Technical Reports Server (NTRS)

    Trinh, Huu P.; Chen, C. P.; Balasubramanyam, M. S.

    2005-01-01

    This paper describes numerical implementation of a newly developed hybrid model, T-blob/T-TAB, into an existing computational fluid dynamics (CFD) program for primary and secondary breakup simulation of liquid jet atomization. This model extend two widely used models, the Kelvin-Helmholtz (KH) instability of Reitz (blob model) and the Taylor-Analogy-Breakup (TAB) secondary droplet breakup by O'Rourke and Amsden to include turbulence effects. In the primary breakup model, the level of the turbulence effect on the liquid breakup depends on the characteristic scales and the initial flow conditions. For the secondary breakup, an additional turbulence force acted on parent drops is modeled and integrated into the TAB governing equation. Several assessment studies are presented and the results indicate that the existing KH and TAB models tend to under-predict the product drop size and spray angle, while the current model provides superior results when compared with the measured data.

  10. Meson-exchange currents including energy transfer effects

    SciTech Connect

    Hwang, W.P.; Walker, G.E.

    1985-01-01

    The standard formalism of meson-exchange currents is extended to incorporate energy transfer effects. It is possible to make such an extension, in a chirally invariant way, for several exchange currents including those involving an intermediate isobar. It is found that the ''extended'' currents still satisfy conservation of the polar vector current (CVC) and partial conservation of the axial vector current (PCAC) where appropriate. The hypothesis of axial locality is found to be valid for the currents considered. Deuteron photodisintegration at intermediate energies is then used to illustrate the numerical importance of the energy transfer effects. A brief survey is carried out for other reactions where the inclusion of energy transfer effects in the evaluation of selected meson-exchange currents is believed important.

  11. Simulation of Accident Sequences Including Emergency Operating Procedures

    SciTech Connect

    Queral, Cesar; Exposito, Antonio; Hortal, Javier

    2004-07-01

    Operator actions play an important role in accident sequences. However, design analysis (Safety Analysis Report, SAR) seldom includes consideration of operator actions, although they are required by compulsory Emergency Operating Procedures (EOP) to perform some checks and actions from the very beginning of the accident. The basic aim of the project is to develop a procedure validation system which consists of the combination of three elements: a plant transient simulation code TRETA (a C based modular program) developed by the CSN, a computerized procedure system COPMA-III (Java technology based program) developed by the OECD-Halden Reactor Project and adapted for simulation with the contribution of our group and a software interface that provides the communication between COPMA-III and TRETA. The new combined system is going to be applied in a pilot study in order to analyze sequences initiated by secondary side breaks in a Pressurized Water Reactors (PWR) plant. (authors)

  12. Sea Surface Temperature from EUMETSAT Including Sentinel-3 SLSTR

    NASA Astrophysics Data System (ADS)

    O'Carroll, Anne; Bonekamp, Hans; Montagner, Francois; Santacesaria, Vincenzo; Tomazic, Igor

    2015-12-01

    The paper gives an overview of sea surface temperature (SST) activities at EUMETSAT including information on SST planned from the Sea and Land Surface Temperature Radiometer (SLSTR). Operational oceanography activities within the Marine Applications group at EUMETSAT continue with a focus on SST, sea surface winds, sea-ice products, radiative fluxes, significant wave height and sea surface topography. These are achieved through the mandatory, optional and third-party programmes, and for some products with the EUMETSAT Ocean and Sea-Ice Satellite Application Facility (OSI SAF). Progress towards products from sea-ice surface temperature, ocean colour products, turbidity and aerosol optical depth over water continue. Information on oceanography products from EUMETSAT can be found through the product navigator (http://navigator.eumetsat.int). EUMETSAT have been collaborating with ESA for a number of years on the development of SST for SLSTR.

  13. Intermediary LEO propagation including higher order zonal harmonics

    NASA Astrophysics Data System (ADS)

    Hautesserres, Denis; Lara, Martin

    2017-04-01

    Two new intermediary orbits of the artificial satellite problem are proposed. The analytical solutions include higher order effects of the geopotential, and are obtained by means of a torsion transformation applied to the quasi-Keplerian system resulting after the elimination of the parallax simplification, for the first intermediary, and after the elimination of the parallax and perigee simplifications, for the second one. The new intermediaries perform notably well for low Earth orbits propagation, are free from special functions, and result advantageous, both in accuracy and efficiency, when compared to the standard Cowell integration of the J_2 problem, thus providing appealing alternatives for onboard, short-term, orbit propagation under limited computational resources.

  14. Improving Planck calibration by including frequency-dependent relativistic corrections

    NASA Astrophysics Data System (ADS)

    Quartin, Miguel; Notari, Alessio

    2015-09-01

    The Planck satellite detectors are calibrated in the 2015 release using the "orbital dipole", which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10-3, due to coupling with the "solar dipole" (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  15. First floor plan. (Also includes a door schedule and door ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    First floor plan. (Also includes a door schedule and door elevations). March Air Force Base, Riverside, California, Combat Operations Center, Combat Operations Building. By Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 12, approved March 1962; specifications no. OCI-62-66; D.O. series AW 1596/12, Rev. "C"; file drawer 1290. Last revised 25 August 1975. Scale one-eighth inch to one foot. 28.5x 41 inches. pencil on paper - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

  16. Cellular automata simulation of traffic including cars and bicycles

    NASA Astrophysics Data System (ADS)

    Vasic, Jelena; Ruskin, Heather J.

    2012-04-01

    As 'greening' of all aspects of human activity becomes mainstream, transportation science is also increasingly focused around sustainability. Modal co-existence between motorised and non-motorised traffic on urban networks is, in this context, of particular interest for traffic flow modelling. The main modelling problems here are posed by the heterogeneity of vehicles, including size and dynamics, and by the complex interactions at intersections. Herein we address these with a novel technique, based on one-dimensional cellular automata components, for modelling network infrastructure and its occupancy by vehicles. We use this modelling approach, together with a corresponding vehicle behaviour model, to simulate combined car and bicycle traffic for two elemental scenarios-examples of components that would be used in the building of an arbitrary network. Results of simulations performed on these scenarios, (i) a stretch of road and (ii) an intersection causing conflict between cars and bicycles sharing a lane, are presented and analysed.

  17. Ball Screw Actuator Including a Compliant Ball Screw Stop

    NASA Technical Reports Server (NTRS)

    Wingett, Paul T. (Inventor); Hanlon, Casey (Inventor)

    2015-01-01

    An actuator includes a ball nut, a ball screw, and a ball screw stop. The ball nut is adapted to receive an input torque and in response rotates and supplies a drive force. The ball screw extends through the ball nut and has a first end and a second end. The ball screw receives the drive force from the ball nut and in response selectively translates between a retract position and a extend position. The ball screw stop is mounted on the ball screw proximate the first end to translate therewith. The ball screw stop engages the ball nut when the ball screw is in the extend position, translates, with compliance, a predetermined distance toward the first end upon engaging the ball nut, and prevents further rotation of the ball screw upon translating the predetermined distance.

  18. Ball Screw Actuator Including an Axial Soft Stop

    NASA Technical Reports Server (NTRS)

    Wingett, Paul T. (Inventor); Forrest, Steven Talbert (Inventor); Abel, Steve (Inventor); Woessner, George (Inventor); Hanlon, Casey (Inventor)

    2016-01-01

    An actuator includes an actuator housing, a ball screw, and an axial soft stop assembly. The ball screw extends through the actuator housing and has a first end and a second end. The ball screw is coupled to receive a drive force and is configured, upon receipt of the drive force, to selectively move in a retract direction and an extend direction. The axial soft stop assembly is disposed within the actuator housing. The axial soft stop assembly is configured to be selectively engaged by the ball screw and, upon being engaged thereby, to translate, with compliance, a predetermined distance in the extend direction, and to prevent further movement of the ball screw upon translating the predetermined distance.

  19. A model of Barchan dunes including lateral shear stress.

    PubMed

    Schwämmle, V; Herrmann, H J

    2005-01-01

    Barchan dunes are found where sand availability is low and wind direction quite constant. The two dimensional shear stress of the wind field and the sand movement by saltation and avalanches over a barchan dune are simulated. The model with one dimensional shear stress is extended including surface diffusion and lateral shear stress. The resulting final shape is compared to the results of the model with a one dimensional shear stress and confirmed by comparison to measurements. We found agreement and improvements with respect to the model with one dimensional shear stress. Additionally, a characteristic edge at the center of the windward side is discovered which is also observed for big barchans. Diffusion effects reduce this effect for small dunes.

  20. Fuel cell repeater unit including frame and separator plate

    DOEpatents

    Yamanis, Jean; Hawkes, Justin R; Chiapetta, Jr., Louis; Bird, Connie E; Sun, Ellen Y; Croteau, Paul F

    2013-11-05

    An example fuel cell repeater includes a separator plate and a frame establishing at least a portion of a flow path that is operative to communicate fuel to or from at least one fuel cell held by the frame relative to the separator plate. The flow path has a perimeter and any fuel within the perimeter flow across the at least one fuel cell in a first direction. The separator plate, the frame, or both establish at least one conduit positioned outside the flow path perimeter. The conduit is outside of the flow path perimeter and is configured to direct flow in a second, different direction. The conduit is fluidly coupled with the flow path.

  1. Numerical Modeling of Electroacoustic Logging Including Joule Heating

    NASA Astrophysics Data System (ADS)

    Plyushchenkov, Boris D.; Nikitin, Anatoly A.; Turchaninov, Victor I.

    It is well known that electromagnetic field excites acoustic wave in a porous elastic medium saturated with fluid electrolyte due to electrokinetic conversion effect. Pride's equations describing this process are written in isothermal approximation. Update of these equations, which allows to take influence of Joule heating on acoustic waves propagation into account, is proposed here. This update includes terms describing the initiation of additional acoustic waves excited by thermoelastic stresses and the heat conduction equation with right side defined by Joule heating. Results of numerical modeling of several problems of propagation of acoustic waves excited by an electric field source with and without consideration of Joule heating effect in their statements are presented. From these results, it follows that influence of Joule heating should be taken into account at the numerical simulation of electroacoustic logging and at the interpretation of its log data.

  2. Equipment Location Plan, partial basement plan. (Includes identification of each ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Equipment Location Plan, partial basement plan. (Includes identification of each separate CPU, tape drive, hard drive, printer, keyboard, etc., within the data processing center in the southeast part of the basement.) March Air Force Base, Riverside, California, Combat Operations Center, 465-L DPC. By International Electric Corporation, Paramus, New Jersey (3/5/62); for Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 100, approved March, 1962; specifications no. OCI-62-66; D.O. series AW 1596/100, Rev. "A"; file drawer 1290. Last revised 3 October 1966. Scale one-quarter inch to one foot. 28.75x40.5 inches. ink on linen - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

  3. Equipment Location Plan, partial first floor plan. (Includes identification of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Equipment Location Plan, partial first floor plan. (Includes identification of each separate CPU, tape drive, hard drive, printer, keyboard, etc., within the data processing center in the southwest part of the first floor.) March Air Force Base, Riverside, California, Combat Operations Center, 465-L EDTCC/EDLCC. By International Electric Corporation, Paramus, New Jersey (3/5/62); for Moffatt and Nichol, Engineers, 122 West Fifth Street, Long Beach, California; for the Corps of Engineers, U.S. Army, Office of the District Engineer, Los Angeles, California. Drawing no. AW-60-02-03, sheet no. 85, approved March, 1962; specifications no. OCI-62-66; D.O. series AW 1596/85, Rev. "A"; file drawer 1290. Last revised 3 October 1966. Scale one-quarter inch to one foot. 28.75x40.5 inches. ink on linen - March Air Force Base, Strategic Air Command, Combat Operations Center, 5220 Riverside Drive, Moreno Valley, Riverside County, CA

  4. Atomic electron energies including relativistic effects and quantum electrodynamic corrections

    NASA Technical Reports Server (NTRS)

    Aoyagi, M.; Chen, M. H.; Crasemann, B.; Huang, K. N.; Mark, H.

    1977-01-01

    Atomic electron energies have been calculated relativistically. Hartree-Fock-Slater wave functions served as zeroth-order eigenfunctions to compute the expectation of the total Hamiltonian. A first order correction to the local approximation was thus included. Quantum-electrodynamic corrections were made. For all orbitals in all atoms with 2 less than or equal to Z less than or equal to 106, the following quantities are listed: total energies, electron kinetic energies, electron-nucleus potential energies, electron-electron potential energies consisting of electrostatic and Breit interaction (magnetic and retardation) terms, and vacuum polarization energies. These results will serve for detailed comparison of calculations based on other approaches. The magnitude of quantum electrodynamic corrections is exhibited quantitatively for each state.

  5. Ball Screw Actuator Including a Stop with an Integral Guide

    NASA Technical Reports Server (NTRS)

    Wingett, Paul T. (Inventor); Perek, John (Inventor); Geck, Kellan (Inventor)

    2015-01-01

    An actuator includes a housing assembly, a ball nut, a ball screw, and a ball screw stop. The ball nut is rotationally mounted in the housing assembly, is adapted to receive an input torque, and is configured, upon receipt thereof, to rotate and supply a drive force. The ball screw is mounted within the housing assembly and extends through the ball nut. The ball screw has a first end and a second end, and is coupled to receive the drive force from the ball nut. The ball screw is configured, upon receipt of the drive force, to selectively translate between a stow position and a deploy position. The ball screw stop is mounted on the ball screw to translate therewith and is configured to at selectively engage the housing assembly while the ball screw is translating, and engage the ball nut when the ball screw is in the deploy position.

  6. Pulse transmission transmitter including a higher order time derivate filter

    DOEpatents

    Dress, Jr., William B.; Smith, Stephen F.

    2003-09-23

    Systems and methods for pulse-transmission low-power communication modes are disclosed. A pulse transmission transmitter includes: a clock; a pseudorandom polynomial generator coupled to the clock, the pseudorandom polynomial generator having a polynomial load input; an exclusive-OR gate coupled to the pseudorandom polynomial generator, the exclusive-OR gate having a serial data input; a programmable delay circuit coupled to both the clock and the exclusive-OR gate; a pulse generator coupled to the programmable delay circuit; and a higher order time derivative filter coupled to the pulse generator. The systems and methods significantly reduce lower-frequency emissions from pulse transmission spread-spectrum communication modes, which reduces potentially harmful interference to existing radio frequency services and users and also simultaneously permit transmission of multiple data bits by utilizing specific pulse shapes.

  7. Preferential Biases for Texts That Include Neuroscientific Jargon.

    PubMed

    Tabacchi, Marco E; Cardaci, Maurizio

    2016-06-01

    The results of an experiment of preferential biases for texts that include neuroscientific jargon are presented. Such preferential bias has been reported even when the presented jargon is meaningless. In a variation of the well-known Weisberg et al. experiment, a group of undergraduate students (N = 150; females 48%, males 52%, other 0%; M age = 22.4 year, SD = 2.6) chose between two possible explanations for a psychological phenomenon: a correct explanation or a circular restatement of facts. Unrelated neuroscientific terms were added to one of the explanations. Participants were asked to choose the correct explanation. There was a statistically significant preference for the explanation without neuroscientific terms. These findings differ from Weisberg et al.'s experiment and a number of others. The implications of this discrepancy are discussed.

  8. Hydraulic engine valve actuation system including independent feedback control

    DOEpatents

    Marriott, Craig D

    2013-06-04

    A hydraulic valve actuation assembly may include a housing, a piston, a supply control valve, a closing control valve, and an opening control valve. The housing may define a first fluid chamber, a second fluid chamber, and a third fluid chamber. The piston may be axially secured to an engine valve and located within the first, second and third fluid chambers. The supply control valve may control a hydraulic fluid supply to the piston. The closing control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the second fluid chamber to the supply control valve. The opening control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the supply control valve to the second fluid chamber.

  9. Precision Obesity Treatments Including Pharmacogenetic and Nutrigenetic Approaches.

    PubMed

    Solas, Maite; Milagro, Fermin I; Martínez-Urbistondo, Diego; Ramirez, Maria J; Martínez, J Alfredo

    2016-07-01

    Five pharmaceutical strategies are currently approved by the US FDA for the treatment of obesity: orlistat, lorcaserin, liraglutide, phentermine/topiramate, and bupropion/naltrexone. The most effective treatment seems to be the combined administration of phentermine/topiramate followed by lorcaserin and bupropion/naltrexone. In relation to the management of excessive weight, other aspects also need to be considered, including comorbidities accompanying obesity, drug interactions, and the risk of negative collateral effects, as well as individualized treatments based on the genetic make-up. This review aims to provide an overview of the approved anti-obesity drugs and newer molecules that could affect different targets in the central nervous system or peripheral tissues, the molecular mechanisms, emerging dietary treatments and phytogenic compounds, and pharmacogenetic/nutrigenetic approaches for personalized obesity management.

  10. Magnetic reconnection in Hall-MHD including electron inertia

    NASA Astrophysics Data System (ADS)

    Gomez, D. O.; Andres, N.; Martin, L. N.; Dmitruk, P.

    2013-12-01

    Magnetic reconnection is an important energy conversion process in highly conducting plasmas, such as those present in the solar corona or in planetary magnetospheres. Within the framework of resistive one-fluid MHD, the Sweet-Parker model leads to extremely low reconnection rates for virtually all space physics applications. Kinetic plasma effects introduce new spatial and temporal scales into the theoretical description, which might significantly increase the reconnection rates. Within the more general framework of two-fluid MHD for a fully ionized hydrogen plasma, we retain the effects of the Hall current and electron inertia. We performed 2.5D Hall MHD simulations including electron inertia using a pseudo-spectral code which yields exact conservation (to round-off errors) of all the ideal invariants. We obtain finite reconnection rates even in the case of zero resistivity, thus showing the important influence of the electron inertia.

  11. Double-photoionization of helium including quadrupole radiation effects

    SciTech Connect

    Colgan, James; Ludlow, J A; Lee, Teck - Ghee; Pindzola, M S; Robicheaux, F

    2009-01-01

    Non-perturbative time-dependent close-coupling calculations are carried out for the double photoionization of helium including both dipole and quadrupole radiation effects. At a photon energy of 800 eV, accessible at CUlTent synchrotron light sources, the quadrupole interaction contributes around 6% to the total integral double photoionization cross section. The pure quadrupole single energy differential cross section shows a local maxima at equal energy sharing, as opposed to the minimum found in the pure dipole single energy differential cross section. The sum of the pure dipole and pure quadrupole single energy differentials is insensitive to non-dipole effects at 800 eV. However, the triple differential cross section at equal energy sharing of the two ejected electrons shows strong non-dipole effects due to the quadrupole interaction that may be experimentally observable.

  12. A model for including thermal conduction in molecular dynamics simulations

    NASA Technical Reports Server (NTRS)

    Wu, Yue; Friauf, Robert J.

    1989-01-01

    A technique is introduced for including thermal conduction in molecular dynamics simulations for solids. A model is developed to allow energy flow between the computational cell and the bulk of the solid when periodic boundary conditions cannot be used. Thermal conduction is achieved by scaling the velocities of atoms in a transitional boundary layer. The scaling factor is obtained from the thermal diffusivity, and the results show good agreement with the solution for a continuous medium at long times. The effects of different temperature and size of the system, and of variations in strength parameter, atomic mass, and thermal diffusivity were investigated. In all cases, no significant change in simulation results has been found.

  13. Oscillatory burning of solid propellants including gas phase time lag.

    NASA Technical Reports Server (NTRS)

    T'Ien, J. S.

    1972-01-01

    An analysis has been performed for oscillatory burning of solid propellants including gas phase time lag. The gaseous flame is assumed to be premixed and laminar with a one-step overall chemical reaction. The propellant is assumed to decompose according to the Arrenhius Law, with no condensed phase reaction. With this model, strong gas phase resonance has been found in certain cases at the characteristic gas-phase frequencies, but the peaking of the acoustic admittance is in the direction favoring the damping of pressure waves. At still higher frequencies, moderate wave-amplifying ability was found. The limit of low frequency response obtained previously by Denison and Baum was recovered, and the limitations of the quasi-steady theory were investigated.

  14. Extending Vulnerability Assessment to Include Life Stages Considerations

    PubMed Central

    Hodgson, Emma E.; Essington, Timothy E.; Kaplan, Isaac C.

    2016-01-01

    Species are experiencing a suite of novel stressors from anthropogenic activities that have impacts at multiple scales. Vulnerability assessment is one tool to evaluate the likely impacts that these stressors pose to species so that high-vulnerability cases can be identified and prioritized for monitoring, protection, or mitigation. Commonly used semi-quantitative methods lack a framework to explicitly account for differences in exposure to stressors and organism responses across life stages. Here we propose a modification to commonly used spatial vulnerability assessment methods that includes such an approach, using ocean acidification in the California Current as an illustrative case study. Life stage considerations were included by assessing vulnerability of each life stage to ocean acidification and were used to estimate population vulnerability in two ways. We set population vulnerability equal to: (1) the maximum stage vulnerability and (2) a weighted mean across all stages, with weights calculated using Lefkovitch matrix models. Vulnerability was found to vary across life stages for the six species explored in this case study: two krill–Euphausia pacifica and Thysanoessa spinifera, pteropod–Limacina helicina, pink shrimp–Pandalus jordani, Dungeness crab–Metacarcinus magister and Pacific hake–Merluccius productus. The maximum vulnerability estimates ranged from larval to subadult and adult stages with no consistent stage having maximum vulnerability across species. Similarly, integrated vulnerability metrics varied greatly across species. A comparison showed that some species had vulnerabilities that were similar between the two metrics, while other species’ vulnerabilities varied substantially between the two metrics. These differences primarily resulted from cases where the most vulnerable stage had a low relative weight. We compare these methods and explore circumstances where each method may be appropriate. PMID:27416031

  15. Extending Vulnerability Assessment to Include Life Stages Considerations.

    PubMed

    Hodgson, Emma E; Essington, Timothy E; Kaplan, Isaac C

    2016-01-01

    Species are experiencing a suite of novel stressors from anthropogenic activities that have impacts at multiple scales. Vulnerability assessment is one tool to evaluate the likely impacts that these stressors pose to species so that high-vulnerability cases can be identified and prioritized for monitoring, protection, or mitigation. Commonly used semi-quantitative methods lack a framework to explicitly account for differences in exposure to stressors and organism responses across life stages. Here we propose a modification to commonly used spatial vulnerability assessment methods that includes such an approach, using ocean acidification in the California Current as an illustrative case study. Life stage considerations were included by assessing vulnerability of each life stage to ocean acidification and were used to estimate population vulnerability in two ways. We set population vulnerability equal to: (1) the maximum stage vulnerability and (2) a weighted mean across all stages, with weights calculated using Lefkovitch matrix models. Vulnerability was found to vary across life stages for the six species explored in this case study: two krill-Euphausia pacifica and Thysanoessa spinifera, pteropod-Limacina helicina, pink shrimp-Pandalus jordani, Dungeness crab-Metacarcinus magister and Pacific hake-Merluccius productus. The maximum vulnerability estimates ranged from larval to subadult and adult stages with no consistent stage having maximum vulnerability across species. Similarly, integrated vulnerability metrics varied greatly across species. A comparison showed that some species had vulnerabilities that were similar between the two metrics, while other species' vulnerabilities varied substantially between the two metrics. These differences primarily resulted from cases where the most vulnerable stage had a low relative weight. We compare these methods and explore circumstances where each method may be appropriate.

  16. Suggestions for revised definitions of noise quantities, including quantum effects

    NASA Astrophysics Data System (ADS)

    Kerr, A. R.

    1999-03-01

    Recent advances in millimeter- and submillimeter-wavelength receivers and the development of low-noise optical amplifiers focus attention on inconsistencies and ambiguities in the standard definitions of noise quantities and the procedures for measuring them. The difficulty is caused by the zero-point (quantum) noise hf/2 W/Hz, which is present even at absolute zero temperature, and also by the nonlinear dependence at low temperature of the thermal noise power of a resistor on its physical temperature, as given by the Planck law. Until recently, these effects were insignificant in all but the most exotic experiments, and the familiar Rayleigh-Jeans noise formula P=kT W/Hz could safely be used in most situations, Now, particularly in low-noise millimeter-wave and photonic devices, the quantum noise is prominent and the nonlinearity of the Planck law can no longer be neglected. The IEEE Standard Dictionary of Electrical and Electronics Terms gives several definitions of the noise temperature of a resistor or a port, which include: 1) the physical temperature of the resistor and 2) its available noise power density divided by Boltzmann's constant-definitions which are incompatible because of the nature of the Planck radiation law. In addition, there is no indication of whether the zero-point noise should be included as part of the noise temperature. Revised definitions of the common noise quantities are suggested, which resolve the shortcomings of the present definitions. The revised definitions have only a small effect on most RF and microwave measurements, but they provide a common consistent noise terminology from dc to light frequencies.

  17. Benchmark Composite Wing Design Including Joint Analysis and Optimization

    NASA Astrophysics Data System (ADS)

    Albers, Robert G.

    A composite wing panel software package, named WING Joint OpTimization and Analysis (WINGJOTA) featuring bolted joint analysis, is created and presented in this research. Three areas of focus were the development of an analytic composite bolted joint analysis suitable for fast evaluation; a more realistic wing design than what has been considered in the open literature; and the application of two optimization algorithms for composite wing design. Optimization results from 14 wing load cases applied to a composite wing panel with joints are presented. The composite bolted joint analysis consists of an elasticity solution that provides the stress state at a characteristic distance away from the bolt holes. The stresses at the characteristic distance are compared to a failure criterion on a ply-by-ply basis that not only determines first ply failure but also the failure mode. The loads in the multi-fastener joints used in this study were determined by an iterative scheme that provides the bearing-bypass loads to the elasticity analysis. A preliminary design of a composite subsonic transport wing was developed, based around a mid-size, twin-aisle aircraft. The benchmark design includes the leading and trailing edge structures and the center box inside the fuselage. Wing masses were included as point loads, and fuel loads were incorporated as distributed loads. The side-of-body boundary condition was modeled using high stiffness springs, and the aerodynamic loads were applied using an approximate point load scheme. The entire wing structure was modeled using the finite element code ANSYS to provide the internal loads needed as boundary conditions for the wing panel analyzed by WINGJOTA. The software package WINGJOTA combines the composite bolted joint analysis, a composite plate finite element analysis, a wing aeroelastic cycle, and two optimization algorithms to form the basis of a computer code for analysis and optimization. Both the Improving Hit-and-Run (IHR) and

  18. Universal health coverage in 'One ASEAN': are migrants included?

    PubMed

    Guinto, Ramon Lorenzo Luis R; Curran, Ufara Zuwasti; Suphanchaimat, Rapeepong; Pocock, Nicola S

    2015-01-01

    Background As the Association of South East Asian Nations (ASEAN) gears toward full regional integration by 2015, the cross-border mobility of workers and citizens at large is expected to further intensify in the coming years. While ASEAN member countries have already signed the Declaration on the Protection and Promotion of the Rights of Migrant Workers, the health rights of migrants still need to be addressed, especially with ongoing universal health coverage (UHC) reforms in most ASEAN countries. This paper seeks to examine the inclusion of migrants in the UHC systems of five ASEAN countries which exhibit diverse migration profiles and are currently undergoing varying stages of UHC development. Design A scoping review of current migration trends and policies as well as ongoing UHC developments and migrant inclusion in UHC in Indonesia, Malaysia, Philippines, Singapore, and Thailand was conducted. Results In general, all five countries, whether receiving or sending, have schemes that cover migrants to varying extents. Thailand even allows undocumented migrants to opt into its Compulsory Migrant Health Insurance scheme, while Malaysia and Singapore are still yet to consider including migrants in their government-run UHC systems. In terms of predominantly sending countries, the Philippines's social health insurance provides outbound migrants with portable insurance yet with limited benefits, while Indonesia still needs to strengthen the implementation of its compulsory migrant insurance which has a health insurance component. Overall, the five ASEAN countries continue to face implementation challenges, and will need to improve on their UHC design in order to ensure genuine inclusion of migrants, including undocumented migrants. However, such reforms will require strong political decisions from agencies outside the health sector that govern migration and labor policies. Furthermore, countries must engage in multilateral and bilateral dialogue as they redefine UHC

  19. C -parameter distribution at N3LL' including power corrections

    NASA Astrophysics Data System (ADS)

    Hoang, André H.; Kolodrubetz, Daniel W.; Mateu, Vicent; Stewart, Iain W.

    2015-05-01

    We compute the e+e- C -parameter distribution using the soft-collinear effective theory with a resummation to next-to-next-to-next-to-leading-log prime accuracy of the most singular partonic terms. This includes the known fixed-order QCD results up to O (αs3), a numerical determination of the two-loop nonlogarithmic term of the soft function, and all logarithmic terms in the jet and soft functions up to three loops. Our result holds for C in the peak, tail, and far tail regions. Additionally, we treat hadronization effects using a field theoretic nonperturbative soft function, with moments Ωn. To eliminate an O (ΛQCD) renormalon ambiguity in the soft function, we switch from the MS ¯ to a short distance "Rgap" scheme to define the leading power correction parameter Ω1. We show how to simultaneously account for running effects in Ω1 due to renormalon subtractions and hadron-mass effects, enabling power correction universality between C -parameter and thrust to be tested in our setup. We discuss in detail the impact of resummation and renormalon subtractions on the convergence. In the relevant fit region for αs(mZ) and Ω1, the perturbative uncertainty in our cross section is ≃ 2.5 % at Q =mZ.

  20. Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays.

    PubMed

    Varney, Michael W; Aslam, Dean M; Janoudi, Abed; Chan, Ho-Yin; Wang, Donna H

    2011-08-15

    Diamond is a material of interest due to its unique combination of properties, including its chemical inertness and biocompatibility. Polycrystalline diamond (poly-C) has been used in experimental biosensors that utilize electrochemical methods and antigen-antibody binding for the detection of biological molecules. Boron-doped poly-C electrodes have been found to be very advantageous for electrochemical applications due to their large potential window, low background current and noise, and low detection limits (as low as 500 fM). The biocompatibility of poly-C is found to be comparable, or superior to, other materials commonly used for implants, such as titanium and 316 stainless steel. We have developed a diamond-based, neural microelectrode-array (MEA), due to the desirability of poly-C as a biosensor. These diamond probes have been used for in vivo electrical recording and in vitro electrochemical detection. Poly-C electrodes have been used for electrical recording of neural activity. In vitro studies indicate that the diamond probe can detect norepinephrine at a 5 nM level. We propose a combination of diamond micro-machining and surface functionalization for manufacturing diamond pathogen-microsensors.

  1. Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays

    PubMed Central

    Varney, Michael W.; Aslam, Dean M.; Janoudi, Abed; Chan, Ho-Yin; Wang, Donna H.

    2011-01-01

    Diamond is a material of interest due to its unique combination of properties, including its chemical inertness and biocompatibility. Polycrystalline diamond (poly-C) has been used in experimental biosensors that utilize electrochemical methods and antigen-antibody binding for the detection of biological molecules. Boron-doped poly-C electrodes have been found to be very advantageous for electrochemical applications due to their large potential window, low background current and noise, and low detection limits (as low as 500 fM). The biocompatibility of poly-C is found to be comparable, or superior to, other materials commonly used for implants, such as titanium and 316 stainless steel. We have developed a diamond-based, neural microelectrode-array (MEA), due to the desirability of poly-C as a biosensor. These diamond probes have been used for in vivo electrical recording and in vitro electrochemical detection. Poly-C electrodes have been used for electrical recording of neural activity. In vitro studies indicate that the diamond probe can detect norepinephrine at a 5 nM level. We propose a combination of diamond micro-machining and surface functionalization for manufacturing diamond pathogen-microsensors. PMID:25586924

  2. A new solar cycle model including meridional circulation

    NASA Technical Reports Server (NTRS)

    Wang, Y.-M.; Sheeley, N. R., Jr.; Nash, A. G.

    1991-01-01

    A kinematic model is presented for the solar cycle which includes not only the transport of magnetic flux by supergranular diffusion and a poleward bulk flow at the sun's surface, but also the effects of turbulent diffusion and an equatorward 'return flow' beneath the surface. As in the earlier models of Babcock and Leighton, the rotational shearing of a subsurface poloidal field generates toroidal flux that erupts at the surface in the form of bipolar magnetic regions. However, such eruptions do not result in any net loss of toroidal flux from the sun (as assumed by Babcock and Leighton); instead, the large-scale toroidal field is destroyed both by 'unwinding' as the local poloidal field reverses its polarity, and by diffusion as the toroidal flux is transported equatorward by the subsurface flow and merged with its opposite hemisphere counterpart. The inclusion of meridional circulation allows stable oscillations of the magnetic field, accompanied by the equatorward progression of flux eruptions, to be achieved even in the absence of a radial gradient in the angular velocity. An illustrative case in which a subsurface flow speed of order 1 m/s and subsurface diffusion rate of order 10 sq km/s yield 22-yr oscillations in qualitative agreement with observations.

  3. Hydrous mantle transition zone indicated by ringwoodite included within diamond.

    PubMed

    Pearson, D G; Brenker, F E; Nestola, F; McNeill, J; Nasdala, L; Hutchison, M T; Matveev, S; Mather, K; Silversmit, G; Schmitz, S; Vekemans, B; Vincze, L

    2014-03-13

    The ultimate origin of water in the Earth's hydrosphere is in the deep Earth--the mantle. Theory and experiments have shown that although the water storage capacity of olivine-dominated shallow mantle is limited, the Earth's transition zone, at depths between 410 and 660 kilometres, could be a major repository for water, owing to the ability of the higher-pressure polymorphs of olivine--wadsleyite and ringwoodite--to host enough water to comprise up to around 2.5 per cent of their weight. A hydrous transition zone may have a key role in terrestrial magmatism and plate tectonics, yet despite experimental demonstration of the water-bearing capacity of these phases, geophysical probes such as electrical conductivity have provided conflicting results, and the issue of whether the transition zone contains abundant water remains highly controversial. Here we report X-ray diffraction, Raman and infrared spectroscopic data that provide, to our knowledge, the first evidence for the terrestrial occurrence of any higher-pressure polymorph of olivine: we find ringwoodite included in a diamond from Juína, Brazil. The water-rich nature of this inclusion, indicated by infrared absorption, along with the preservation of the ringwoodite, is direct evidence that, at least locally, the transition zone is hydrous, to about 1 weight per cent. The finding also indicates that some kimberlites must have their primary sources in this deep mantle region.

  4. SAGE II aerosol validation: selected altitude measurements, including particle micromeasurements.

    PubMed

    Oberbeck, V R; Livingston, J M; Russell, P B; Pueschel, R F; Rosen, J N; Osborn, M T; Kritz, M A; Snetsinger, K G; Ferry, G V

    1989-06-20

    Correlative aerosol measurements taken at a limited number of altitudes during coordinated field experiments are used to test the validity of particulate extinction coefficients derived from limb path solar radiance measurements taken by the Stratospheric Aerosol and Gas Experiment (SAGE) II Sun photometer. In particular, results are presented from correlative measurement missions that were conducted during January 1985, August 1985, and July 1986. Correlative sensors included impactors, laser spectrometers, and filter samplers aboard an U-2-airplane, an upward pointing lidar aboard a P-3 airplane, and balloon-borne optical particle counters (dustsondes). The main body of this paper focuses on the July 29, 1986, validation experiment, which minimized the many difficulties (e.g., spatial and temporal inhomogeneities, imperfect coincidences) that can complicate the validation process. On this day, correlative aerosol measurements taken at an altitude of 20.5 km agreed with each other within their respective uncertainties, and particulate extinction values calculated at SAGE II wavelengths from these measurements validated corresponding SAGE II values. Additional validation efforts on days when measurement and logistical conditions were much less favorable for validation are discussed in an appendix.

  5. Advances in pleural disease management including updated procedural coding.

    PubMed

    Haas, Andrew R; Sterman, Daniel H

    2014-08-01

    Over 1.5 million pleural effusions occur in the United States every year as a consequence of a variety of inflammatory, infectious, and malignant conditions. Although rarely fatal in isolation, pleural effusions are often a marker of a serious underlying medical condition and contribute to significant patient morbidity, quality-of-life reduction, and mortality. Pleural effusion management centers on pleural fluid drainage to relieve symptoms and to investigate pleural fluid accumulation etiology. Many recent studies have demonstrated important advances in pleural disease management approaches for a variety of pleural fluid etiologies, including malignant pleural effusion, complicated parapneumonic effusion and empyema, and chest tube size. The last decade has seen greater implementation of real-time imaging assistance for pleural effusion management and increasing use of smaller bore percutaneous chest tubes. This article will briefly review recent pleural effusion management literature and update the latest changes in common procedural terminology billing codes as reflected in the changing landscape of imaging use and percutaneous approaches to pleural disease management.

  6. Interim performance criteria for photovoltaic energy systems. [Glossary included

    SciTech Connect

    DeBlasio, R.; Forman, S.; Hogan, S.; Nuss, G.; Post, H.; Ross, R.; Schafft, H.

    1980-12-01

    This document is a response to the Photovoltaic Research, Development, and Demonstration Act of 1978 (P.L. 95-590) which required the generation of performance criteria for photovoltaic energy systems. Since the document is evolutionary and will be updated, the term interim is used. More than 50 experts in the photovoltaic field have contributed in the writing and review of the 179 performance criteria listed in this document. The performance criteria address characteristics of present-day photovoltaic systems that are of interest to manufacturers, government agencies, purchasers, and all others interested in various aspects of photovoltaic system performance and safety. The performance criteria apply to the system as a whole and to its possible subsystems: array, power conditioning, monitor and control, storage, cabling, and power distribution. They are further categorized according to the following performance attributes: electrical, thermal, mechanical/structural, safety, durability/reliability, installation/operation/maintenance, and building/site. Each criterion contains a statement of expected performance (nonprescriptive), a method of evaluation, and a commentary with further information or justification. Over 50 references for background information are also given. A glossary with definitions relevant to photovoltaic systems and a section on test methods are presented in the appendices. Twenty test methods are included to measure performance characteristics of the subsystem elements. These test methods and other parts of the document will be expanded or revised as future experience and needs dictate.

  7. Including public perspectives in industrial biotechnology and the biobased economy.

    PubMed

    Paula, Lino; Birrer, Frans

    2006-01-01

    Industrial ("white") biotechnology promises to contribute to a more sustainable future. Compared to current production processes, cases have been identified where industrial biotechnology can decrease the amount of energy and raw materials used to make products and also reduce the amount of emissions and waste produced during production. However, switching from products based on chemical production processes and fossil fuels towards "biobased" products is at present not necessarily economically viable. This is especially true for bulk products, for example ethanol production from biomass. Therefore, scientists are also turning to genetic modification as a means to develop organisms that can produce at lower costs. These include not only micro-organisms, but also organisms used in agriculture for food and feed. The use of genetic modification for "deliberate release" purposes, in particular, has met great opposition in Europe. Many industrial biotechnology applications may, due to their scale, entail deliberate releases of GM organisms. Thus, the biobased economy brings back a familiar question; is it ethically justifiable, and acceptable to citizens, to expose the environment and society to the risks associated with GM, in order to protect that same environment and to sustain our affluent way of life? For a successful innovation towards a biobased economy, its proponents, especially producers, need to take into account (take responsibility for) such issues when developing new products and processes. These issues, and how scientists can interact with citizens about them in a timely way, are further explored in projects at Delft University and Leiden University, also in collaboration with Utrecht University.

  8. cDNA encoding a polypeptide including a hevein sequence

    DOEpatents

    Raikhel, N.V.; Broekaert, W.F.; Chua, N.H.; Kush, A.

    1995-03-21

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1,018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a putative signal sequence of 17 amino acid residues followed by a 187 amino acid polypeptide. The amino-terminal region (43 amino acids) is identical to hevein and shows homology to several chitin-binding proteins and to the amino-termini of wound-induced genes in potato and poplar. The carboxyl-terminal portion of the polypeptide (144 amino acids) is 74--79% homologous to the carboxyl-terminal region of wound-inducible genes of potato. Wounding, as well as application of the plant hormones abscisic acid and ethylene, resulted in accumulation of hevein transcripts in leaves, stems and latex, but not in roots, as shown by using the cDNA as a probe. A fusion protein was produced in E. coli from the protein of the present invention and maltose binding protein produced by the E. coli. 11 figures.

  9. Accurate SHAPE-directed RNA secondary structure modeling, including pseudoknots

    PubMed Central

    Hajdin, Christine E.; Bellaousov, Stanislav; Huggins, Wayne; Leonard, Christopher W.; Mathews, David H.; Weeks, Kevin M.

    2013-01-01

    A pseudoknot forms in an RNA when nucleotides in a loop pair with a region outside the helices that close the loop. Pseudoknots occur relatively rarely in RNA but are highly overrepresented in functionally critical motifs in large catalytic RNAs, in riboswitches, and in regulatory elements of viruses. Pseudoknots are usually excluded from RNA structure prediction algorithms. When included, these pairings are difficult to model accurately, especially in large RNAs, because allowing this structure dramatically increases the number of possible incorrect folds and because it is difficult to search the fold space for an optimal structure. We have developed a concise secondary structure modeling approach that combines SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension) experimental chemical probing information and a simple, but robust, energy model for the entropic cost of single pseudoknot formation. Structures are predicted with iterative refinement, using a dynamic programming algorithm. This melded experimental and thermodynamic energy function predicted the secondary structures and the pseudoknots for a set of 21 challenging RNAs of known structure ranging in size from 34 to 530 nt. On average, 93% of known base pairs were predicted, and all pseudoknots in well-folded RNAs were identified. PMID:23503844

  10. cDNA encoding a polypeptide including a hevein sequence

    DOEpatents

    Raikhel, N.V.; Broekaert, W.F.; Chua, N.H.; Kush, A.

    1999-05-04

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a putative signal sequence of 17 amino acid residues followed by a 187 amino acid polypeptide. The amino-terminal region (43 amino acids) is identical to hevein and shows homology to several chitin-binding proteins and to the amino-termini of wound-induced genes in potato and poplar. The carboxyl-terminal portion of the polypeptide (144 amino acids) is 74--79% homologous to the carboxyl-terminal region of wound-inducible genes of potato. Wounding, as well as application of the plant hormones abscisic acid and ethylene, resulted in accumulation of hevein transcripts in leaves, stems and latex, but not in roots, as shown by using the cDNA as a probe. A fusion protein was produced in E. coli from the protein of the present invention and maltose binding protein produced by the E. coli. 12 figs.

  11. CDNA encoding a polypeptide including a hevein sequence

    DOEpatents

    Raikhel, Natasha V.; Broekaert, Willem F.; Chua, Nam-Hai; Kush, Anil

    1995-03-21

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a putative signal sequence of 17 amino acid residues followed by a 187 amino acid polypeptide. The amino-terminal region (43 amino acids) is identical to hevein and shows homology to several chitin-binding proteins and to the amino-termini of wound-induced genes in potato and poplar. The carboxyl-terminal portion of the polypeptide (144 amino acids) is 74-79% homologous to the carboxyl-terminal region of wound-inducible genes of potato. Wounding, as well as application of the plant hormones abscisic acid and ethylene, resulted in accumulation of hevein transcripts in leaves, stems and latex, but not in roots, as shown by using the cDNA as a probe. A fusion protein was produced in E. coli from the protein of the present invention and maltose binding protein produced by the E. coli.

  12. cDNA encoding a polypeptide including a hevein sequence

    DOEpatents

    Raikhel, Natasha V.; Broekaert, Willem F.; Chua, Nam-Hai; Kush, Anil

    1999-05-04

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a putative signal sequence of 17 amino acid residues followed by a 187 amino acid polypeptide. The amino-terminal region (43 amino acids) is identical to hevein and shows homology to several chitin-binding proteins and to the amino-termini of wound-induced genes in potato and poplar. The carboxyl-terminal portion of the polypeptide (144 amino acids) is 74-79% homologous to the carboxyl-terminal region of wound-inducible genes of potato. Wounding, as well as application of the plant hormones abscisic acid and ethylene, resulted in accumulation of hevein transcripts in leaves, stems and latex, but not in roots, as shown by using the cDNA as a probe. A fusion protein was produced in E. coli from the protein of the present invention and maltose binding protein produced by the E. coli.

  13. Extending GLCM to include Color Information for Texture Recognition

    NASA Astrophysics Data System (ADS)

    Hossain, Kunal; Parekh, Ranjan

    2010-10-01

    This paper proposes an automated system for texture recognition using an extended form of Grey Level Co-occurrence Matrix (GLCM). GLCM provides a popular statistical method for texture recognition, however its basic limitation is that it can only capture information from grey-scale images. To improve recognition accuracies this paper studies the possibilities of including color information from color texture images. Color information is captured by applying GLCM to each of the color channels r, g, b, both individually and in pairs providing 9 Color GLCM (C-GLCM) combinations i.e. rr, gg, bb, rg, rb, gr, gb, br, bg. Symmetrical normalized C-GLCMs computed along four directions 0°, 45°, 90° and 135°, from each of the 9 combinations are used to compute two features viz. GLCM Contrast and GLCM Mean, which are used for texture recognition. Experimental results indicate that C-GLCMs provide better recognition accuracies as compared to standard GLCMs on greyscale images.

  14. DETECTION OF SUBSURFACE FACILITIES INCLUDING NON-METALLIC PIPE

    SciTech Connect

    Mr. Herb Duvoisin

    2003-05-26

    CyTerra has leveraged our unique, shallow buried plastic target detection technology developed under US Army contracts into deeper buried subsurface facilities and including nonmetallic pipe detection. This Final Report describes a portable, low-cost, real-time, and user-friendly subsurface plastic pipe detector (LULU- Low Cost Utility Location Unit) that relates to the goal of maintaining the integrity and reliability of the nation's natural gas transmission and distribution network by preventing third party damage, by detecting potential infringements. Except for frequency band and antenna size, the LULU unit is almost identical to those developed for the US Army. CyTerra designed, fabricated, and tested two frequency stepped GPR systems, spanning the frequencies of importance (200 to 1600 MHz), one low and one high frequency system. Data collection and testing was done at a variety of locations (selected for soil type variations) on both targets of opportunity and selected buried targets. We developed algorithms and signal processing techniques that provide for the automatic detection of the buried utility lines. The real time output produces a sound as the radar passes over the utility line alerting the operator to the presence of a buried object. Our unique, low noise/high performance RF hardware, combined with our field tested detection algorithms, represents an important advancement toward achieving the DOE potential infringement goal.

  15. LOSS ESTIMATE FOR ITER ECH TRANSMISSION LINE INCLUDING MULTIMODE PROPAGATION

    SciTech Connect

    Shapiro, Michael; Bigelow, Tim S; Caughman, John B; Rasmussen, David A

    2010-01-01

    The ITER electron cyclotron heating (ECH) transmission lines (TLs) are 63.5-mm-diam corrugated waveguides that will each carry 1 MW of power at 170 GHz. The TL is defined here as the corrugated wave guide system connecting the gyrotron mirror optics unit (MO U) to the entrance of the ECH launcher and includes miter bends and other corrugated wave guide components. The losses on the ITER TL have been calculated for four possible cases corresponding to having HE(11) mode purity at the input of the TL of 100, 97, 90, and 80%. The losses due to coupling, ohmic, and mode conversion loss are evaluated in detail using a numerical code and analytical approaches. Estimates of the calorimetric loss on the line show that the output power is reduced by about 5, +/- 1% because of ohmic loss in each of the four cases. Estimates of the mode conversion loss show that the fraction of output power in the HE(11) mode is similar to 3% smaller than the fraction of input power in the HE(11) mode. High output mode purity therefore can be achieved only with significantly higher input mode purity. Combining both ohmic and mode conversion loss, the efficiency of the TL from the gyrotron MOU to the ECH launcher can be roughly estimated in theory as 92% times the fraction of input power in the HE(11) mode.

  16. Allogeneic transplantation strategies including haploidentical transplantation in sickle cell disease.

    PubMed

    Gluckman, Eliane

    2013-01-01

    Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Despite antenatal counseling and neonatal screening programs implemented in higher income countries, SCD is still associated with multiple morbidities and early mortality. To date, the only curative approach to SCD is hematopoietic stem cell transplantation, but this therapy is not yet established worldwide. The registries of the European Blood and Marrow Transplant (EBMT) and the Centre for International Blood and Marrow Transplant Research (CIBMTR) account, respectively, for 611 and 627 patients receiving transplantations for SCD. Most of these patients were transplanted with grafts from an HLA-identical sibling donor. The main obstacles to increasing the number of transplantations are a lack of awareness on the part of physicians and families, the absence of reliable prognostic factors for severity, and the perceived risk that transplantation complications may outweigh the benefits of early transplantation. Results show that more than 90% of patients having undergone an HLA-identical sibling transplantation after myeloablative conditioning are cured, with very limited complications. Major improvement is expected from the use of new reduced-toxicity conditioning regimens and the use of alternative donors, including unrelated cord blood transplantations and related haploidentical bone marrow or peripheral blood stem cell transplantations.

  17. Development of an Aeroelastic Analysis Including a Viscous Flow Model

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.; Bakhle, Milind A.

    2001-01-01

    Under this grant, Version 4 of the three-dimensional Navier-Stokes aeroelastic code (TURBO-AE) has been developed and verified. The TURBO-AE Version 4 aeroelastic code allows flutter calculations for a fan, compressor, or turbine blade row. This code models a vibrating three-dimensional bladed disk configuration and the associated unsteady flow (including shocks, and viscous effects) to calculate the aeroelastic instability using a work-per-cycle approach. Phase-lagged (time-shift) periodic boundary conditions are used to model the phase lag between adjacent vibrating blades. The direct-store approach is used for this purpose to reduce the computational domain to a single interblade passage. A disk storage option, implemented using direct access files, is available to reduce the large memory requirements of the direct-store approach. Other researchers have implemented 3D inlet/exit boundary conditions based on eigen-analysis. Appendix A: Aeroelastic calculations based on three-dimensional euler analysis. Appendix B: Unsteady aerodynamic modeling of blade vibration using the turbo-V3.1 code.

  18. C -parameter distribution at N 3 LL ' including power corrections

    DOE PAGES

    Hoang, André H.; Kolodrubetz, Daniel W.; Mateu, Vicent; ...

    2015-05-15

    We compute the e⁺e⁻ C-parameter distribution using the soft-collinear effective theory with a resummation to next-to-next-to-next-to-leading-log prime accuracy of the most singular partonic terms. This includes the known fixed-order QCD results up to O(α3s), a numerical determination of the two-loop nonlogarithmic term of the soft function, and all logarithmic terms in the jet and soft functions up to three loops. Our result holds for C in the peak, tail, and far tail regions. Additionally, we treat hadronization effects using a field theoretic nonperturbative soft function, with moments Ωn. To eliminate an O(ΛQCD) renormalon ambiguity in the soft function, we switchmore » from the MS¯ to a short distance “Rgap” scheme to define the leading power correction parameter Ω1. We show how to simultaneously account for running effects in Ω1 due to renormalon subtractions and hadron-mass effects, enabling power correction universality between C-parameter and thrust to be tested in our setup. We discuss in detail the impact of resummation and renormalon subtractions on the convergence. In the relevant fit region for αs(mZ) and Ω1, the perturbative uncertainty in our cross section is ≅ 2.5% at Q=mZ.« less

  19. Materials issues in some advanced forming techniques, including superplasticity

    SciTech Connect

    Wadsworth, J.; Henshall, G.A.; Nieh, T.G.

    1995-08-22

    From mechanics and macroscopic viewpoints, the sensitivity of the flow stress of a material to the strain rate, i.e. the strain rate sensitivity (m), governs the development of neck formation and therefore has a strong influence on the tensile ductility and hence formability of materials. Values of strain rate sensitivity range from unity, for the case of Newtonian viscous materials, to less than 0.1 for some dispersion strengthened alloys. Intermediate values of m = 0.5 are associated with classical superplastic materials which contain very fine grain sizes following specialized processing. An overview is given of the influence of strain rate sensitivity on tensile ductility and of the various materials groups that can exhibit high values of strain rate sensitivity. Recent examples of enhanced formability (or extended tensile ductility) in specific regimes between m = 1 and m = 0.3 are described, and potential areas for commercial exploitation are noted. These examples include: internal stress superplasticity, superplastic ceramics, superplastic intermetallics, superplastic laminated composites, superplastic behavior over six orders of magnitude of strain rate in a range of aluminum-based alloys and composites, and enhanced ductility in Al-Mg alloys that require no special processing for microstructural development.

  20. ERA's Open Rotor Studies Including Shielding for Noise Reduction

    NASA Technical Reports Server (NTRS)

    Van Zante, Dale; Thomas, Russell

    2012-01-01

    The Open Rotor is a modern version of the UnDucted Fan (UDF) that was flight tested in the late 1980's through a partnership between NASA and General Electric (GE). Tests were conducted in the 9' x 15' Low Speed Wind Tunnel and the 8' x 6' Supersonic Wind Tunnel starting in late 2009 and completed in early 2012. Aerodynamic and acoustic data were obtained for takeoff, approach and cruise simulations. GE was the primary partner, but other organizations were involved such as Boeing and Airbus who provided additional hardware for fuselage simulations. This test campaign provided the acoustic and performance characteristics for modern open rotor blades designs." NASA and GE conducted joint systems analysis to evaluate how well new blade designs would perform on a B737 class aircraft, and compared the results to an advanced higher bypass ratio turbofan." Acoustic shielding experiments were performed at NASA GRC and Boeing LSAF facilities to provide data for noise estimates of unconventional aircraft configurations with Open Rotor propulsion systems." The work was sponsored by NASA's aeronautics programs, including the Subsonic Fixed Wing (SFW) and the Environmentally Responsible Aviation (ERA) projects."

  1. Progress Towards an LES Wall Model Including Unresolved Roughness

    NASA Astrophysics Data System (ADS)

    Craft, Kyle; Redman, Andrew; Aikens, Kurt

    2015-11-01

    Wall models used in large eddy simulations (LES) are often based on theories for hydraulically smooth walls. While this is reasonable for many applications, there are also many where the impact of surface roughness is important. A previously developed wall model has been used primarily for jet engine aeroacoustics. However, jet simulations have not accurately captured thick initial shear layers found in some experimental data. This may partly be due to nozzle wall roughness used in the experiments to promote turbulent boundary layers. As a result, the wall model is extended to include the effects of unresolved wall roughness through appropriate alterations to the log-law. The methodology is tested for incompressible flat plate boundary layers with different surface roughness. Correct trends are noted for the impact of surface roughness on the velocity profile. However, velocity deficit profiles and the Reynolds stresses do not collapse as well as expected. Possible reasons for the discrepancies as well as future work will be presented. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number ACI-1053575. Computational resources on TACC Stampede were provided under XSEDE allocation ENG150001.

  2. Generalization of Equivalent Crystal Theory to Include Angular Dependence

    NASA Technical Reports Server (NTRS)

    Ferrante, John; Zypman, Fredy R.

    2004-01-01

    In the original Equivalent Crystal Theory, each atomic site in the real crystal is assigned an equivalent lattice constant, in general different from the ground state one. This parameter corresponds to a local compression or expansion of the lattice. The basic method considers these volumetric transformations and, in addition, introduces the possibility that the reference lattice is anisotropically distorted. These distortions however, were introduced ad-hoc. In this work, we generalize the original Equivalent Crystal Theory by systematically introducing site-dependent directional distortions of the lattice, whose corresponding distortions account for the dependence of the energy on anisotropic local density variations. This is done in the spirit of the original framework, but including a gradient term in the density. This approach is introduced to correct a deficiency in the original Equivalent Crystal Theory and other semiempirical methods in quantitatively obtaining the correct ratios of the surface energies of low index planes of cubic metals (100), (110), and (111). We develop here the basic framework, and apply it to the calculation of Fe (110) and Fe (111) surface energy formation. The results, compared with first principles calculations, show an improvement over previous semiempirical approaches.

  3. Toothpaste microstructure and rheological behaviors including aging and partial rejuvenation

    NASA Astrophysics Data System (ADS)

    Liu, Zhiwei; Liu, Lei; Zhou, Huan; Wang, Jiali; Deng, Linhong

    2015-08-01

    Toothpastes are mainly composed of a dense suspension of abrasive substances, flavors, and therapeutic ingredients in a background liquid of humectants and water, and usually exhibit complex rheological behaviors. However, the relationship between the rheology and microstructure of toothpaste remains to be studied. In this paper, three commonly used toothpastes, namely Colgate, Darlie and Yunnan Baiyao (Ynby), were qualitatively and quantitatively studied as soft glassy materials. We found that although the three toothpastes generally behaved in similar fashion in terms of rheology, each particular one was distinct from others in terms of the quantitative magnitude of the rheologcial properties including thixotropy, creep and relaxation, yield stress, and power-law dependence of modulus on frequency. In addition, the history-dependent effects were interpreted in terms of aging and rejuvenation phenomena, analogous to those existing in glassy systems, and Ynby seemed to result in greater extent of aging and rejuvenation as compared to the other two. All these differences in toothpaste rheology may well be attributed to the different microscopic network microstructures as observed in this study. Therefore, this study provides first evidence of microstructurebased rheological behaviors of toothpaste, which may be useful for optimizing its composition, manufacturing processing as well as end-user applications.

  4. Expanding marine protected areas to include degraded coral reefs.

    PubMed

    Abelson, A; Nelson, P A; Edgar, G J; Shashar, N; Reed, D C; Belmaker, J; Krause, G; Beck, M W; Brokovich, E; France, R; Gaines, S D

    2016-12-01

    Marine protected areas (MPAs) are a commonly applied solution to coral reef degradation, yet coral reefs continue to decline worldwide. We argue that expanding the range of MPAs to include degraded reefs (DR-MPA) could help reverse this trend. This approach requires new ecological criteria for MPA design, siting, and management. Rather than focusing solely on preserving healthy reefs, our approach focuses on the potential for biodiversity recovery and renewal of ecosystem services. The new criteria would help identify sites with the highest potential for recovery and the greatest resistance to future threats (e.g., increased temperature and acidification) and sites that contribute to MPA connectivity. The DR-MPA approach is a compliment rather than a substitute for traditional MPA design approaches. We believe that the DR-MPA approach can enhance the natural, or restoration-assisted, recovery of DRs and their ecosystem services; increase total reef area available for protection; promote more resilient and better-connected MPA networks; and improve conditions for human communities dependent on MPA ecosystem services.

  5. Extractant composition including crown ether and calixarene extractants

    DOEpatents

    Meikrantz, David H.; Todd, Terry A.; Riddle, Catherine L.; Law, Jack D.; Peterman, Dean R.; Mincher, Bruce J.; McGrath, Christopher A.; Baker, John D.

    2009-04-28

    An extractant composition comprising a mixed extractant solvent consisting of calix[4] arene-bis-(tert-octylbenzo)-crown-6 ("BOBCalixC6"), 4',4',(5')-di-(t-butyldicyclo-hexano)-18-crown-6 ("DtBu18C6"), and at least one modifier dissolved in a diluent. The DtBu18C6 may be present at from approximately 0.01M to approximately 0.4M, such as at from approximately 0.086 M to approximately 0.108 M. The modifier may be 1-(2,2,3,3-tetrafluoropropoxy)-3-(4-sec-butylphenoxy)-2-propanol ("Cs-7SB") and may be present at from approximately 0.01M to approximately 0.8M. In one embodiment, the mixed extractant solvent includes approximately 0.15M DtBu18C6, approximately 0.007M BOBCalixC6, and approximately 0.75M Cs-7SB modifier dissolved in an isoparaffinic hydrocarbon diluent. The extractant composition further comprises an aqueous phase. The mixed extractant solvent may be used to remove cesium and strontium from the aqueous phase.

  6. cDNA encoding a polypeptide including a hevein sequence

    SciTech Connect

    Raikhel, N.V.; Broekaert, W.F.; Chua, N.H.; Kush, A.

    2000-07-04

    A cDNA clone (HEV1) encoding hevein was isolated via polymerase chain reaction (PCR) using mixed oligonucleotides corresponding to two regions of hevein as primers and a Hevea brasiliensis latex cDNA library as a template. HEV1 is 1018 nucleotides long and includes an open reading frame of 204 amino acids. The deduced amino acid sequence contains a putative signal sequence of 17 amino acid residues followed by a 187 amino acid polypeptide. The amino-terminal region (43 amino acids) is identical to hevein and shows homology to several chitin-binding proteins and to the amino-termini of wound-induced genes in potato and poplar. The carboxyl-terminal portion of the polypeptide (144 amino acids) is 74--79% homologous to the carboxyl-terminal region of wound-inducible genes of potato. Wounding, as well as application of the plant hormones abscisic acid and ethylene, resulted in accumulation of hevein transcripts in leaves, stems and latex, but not in roots, as shown by using the cDNA as a probe. A fusion protein was produced in E. coli from the protein of the present invention and maltose binding protein produced by the E. coli.

  7. A model of electrical conduction in cardiac tissue including fibroblasts.

    PubMed

    Sachse, Frank B; Moreno, A P; Seemann, G; Abildskov, J A

    2009-05-01

    Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, fibroblasts, and the extracellular space. The model is an extension of established cardiac bidomain models, which include a description of intra-myocyte and extracellular conductivities, currents and potentials in addition to transmembrane voltages of myocytes. Our extension added a description of fibroblasts, which are electrically coupled with each other and with myocytes. We applied the extended model in exemplary computational simulations of plane waves and conduction in a thin tissue slice assuming an isotropic conductivity of the intra-fibroblast domain. In simulations of plane waves, increased myocyte-fibroblast coupling and fibroblast-myocyte ratio reduced peak voltage and maximal upstroke velocity of myocytes as well as amplitudes and maximal downstroke velocity of extracellular potentials. Simulations with the thin tissue slice showed that inter-fibroblast coupling affected rather transversal than longitudinal conduction velocity. Our results suggest that fibroblast coupling becomes relevant for small intra-myocyte and/or large intra-fibroblast conductivity. In summary, the study demonstrated the feasibility of the extended bidomain model and supports the hypothesis that fibroblasts contribute to cardiac electrophysiology in various manners.

  8. A study of helicopter stability and control including blade dynamics

    NASA Technical Reports Server (NTRS)

    Zhao, Xin; Curtiss, H. C., Jr.

    1988-01-01

    A linearized model of rotorcraft dynamics has been developed through the use of symbolic automatic equation generating techniques. The dynamic model has been formulated in a unique way such that it can be used to analyze a variety of rotor/body coupling problems including a rotor mounted on a flexible shaft with a number of modes as well as free-flight stability and control characteristics. Direct comparison of the time response to longitudinal, lateral and directional control inputs at various trim conditions shows that the linear model yields good to very good correlation with flight test. In particular it is shown that a dynamic inflow model is essential to obtain good time response correlation, especially for the hover trim condition. It also is shown that the main rotor wake interaction with the tail rotor and fixed tail surfaces is a significant contributor to the response at translational flight trim conditions. A relatively simple model for the downwash and sidewash at the tail surfaces based on flat vortex wake theory is shown to produce good agreement. Then, the influence of rotor flap and lag dynamics on automatic control systems feedback gain limitations is investigated with the model. It is shown that the blade dynamics, especially lagging dynamics, can severly limit the useable values of the feedback gain for simple feedback control and that multivariable optimal control theory is a powerful tool to design high gain augmentation control system. The frequency-shaped optimal control design can offer much better flight dynamic characteristics and a stable margin for the feedback system without need to model the lagging dynamics.

  9. Community Assessment Tool for Public Health Emergencies Including Pandemic Influenza

    SciTech Connect

    HCTT-CHE

    2011-04-14

    The Community Assessment Tool (CAT) for Public Health Emergencies Including Pandemic Influenza (hereafter referred to as the CAT) was developed as a result of feedback received from several communities. These communities participated in workshops focused on influenza pandemic planning and response. The 2008 through 2011 workshops were sponsored by the Centers for Disease Control and Prevention (CDC). Feedback during those workshops indicated the need for a tool that a community can use to assess its readiness for a disaster—readiness from a total healthcare perspective, not just hospitals, but the whole healthcare system. The CAT intends to do just that—help strengthen existing preparedness plans by allowing the healthcare system and other agencies to work together during an influenza pandemic. It helps reveal each core agency partners' (sectors) capabilities and resources, and highlights cases of the same vendors being used for resource supplies (e.g., personal protective equipment [PPE] and oxygen) by the partners (e.g., public health departments, clinics, or hospitals). The CAT also addresses gaps in the community's capabilities or potential shortages in resources. While the purpose of the CAT is to further prepare the community for an influenza pandemic, its framework is an extension of the traditional all-hazards approach to planning and preparedness. As such, the information gathered by the tool is useful in preparation for most widespread public health emergencies. This tool is primarily intended for use by those involved in healthcare emergency preparedness (e.g., community planners, community disaster preparedness coordinators, 9-1-1 directors, hospital emergency preparedness coordinators). It is divided into sections based on the core agency partners, which may be involved in the community's influenza pandemic influenza response.

  10. Deformable registration of multi-modal data including rigid structures

    SciTech Connect

    Huesman, Ronald H.; Klein, Gregory J.; Kimdon, Joey A.; Kuo, Chaincy; Majumdar, Sharmila

    2003-05-02

    Multi-modality imaging studies are becoming more widely utilized in the analysis of medical data. Anatomical data from CT and MRI are useful for analyzing or further processing functional data from techniques such as PET and SPECT. When data are not acquired simultaneously, even when these data are acquired on a dual-imaging device using the same bed, motion can occur that requires registration between the reconstructed image volumes. As the human torso can allow non-rigid motion, this type of motion should be estimated and corrected. We report a deformation registration technique that utilizes rigid registration for bony structures, while allowing elastic transformation of soft tissue to more accurately register the entire image volume. The technique is applied to the registration of CT and MR images of the lumbar spine. First a global rigid registration is performed to approximately align features. Bony structures are then segmented from the CT data using semi-automated process, and bounding boxes for each vertebra are established. Each CT subvolume is then individually registered to the MRI data using a piece-wise rigid registration algorithm and a mutual information image similarity measure. The resulting set of rigid transformations allows for accurate registration of the parts of the CT and MRI data representing the vertebrae, but not the adjacent soft tissue. To align the soft tissue, a smoothly-varying deformation is computed using a thin platespline(TPS) algorithm. The TPS technique requires a sparse set of landmarks that are to be brought into correspondence. These landmarks are automatically obtained from the segmented data using simple edge-detection techniques and random sampling from the edge candidates. A smoothness parameter is also included in the TPS formulation for characterization of the stiffness of the soft tissue. Estimation of an appropriate stiffness factor is obtained iteratively by using the mutual information cost function on the result

  11. Clinical Reasoning Terms Included in Clinical Problem Solving Exercises?

    PubMed

    Musgrove, John L; Morris, Jason; Estrada, Carlos A; Kraemer, Ryan R

    2016-05-01

    Background Published clinical problem solving exercises have emerged as a common tool to illustrate aspects of the clinical reasoning process. The specific clinical reasoning terms mentioned in such exercises is unknown. Objective We identified which clinical reasoning terms are mentioned in published clinical problem solving exercises and compared them to clinical reasoning terms given high priority by clinician educators. Methods A convenience sample of clinician educators prioritized a list of clinical reasoning terms (whether to include, weight percentage of top 20 terms). The authors then electronically searched the terms in the text of published reports of 4 internal medicine journals between January 2010 and May 2013. Results The top 5 clinical reasoning terms ranked by educators were dual-process thinking (weight percentage = 24%), problem representation (12%), illness scripts (9%), hypothesis generation (7%), and problem categorization (7%). The top clinical reasoning terms mentioned in the text of 79 published reports were context specificity (n = 20, 25%), bias (n = 13, 17%), dual-process thinking (n = 11, 14%), illness scripts (n = 11, 14%), and problem representation (n = 10, 13%). Context specificity and bias were not ranked highly by educators. Conclusions Some core concepts of modern clinical reasoning theory ranked highly by educators are mentioned explicitly in published clinical problem solving exercises. However, some highly ranked terms were not used, and some terms used were not ranked by the clinician educators. Effort to teach clinical reasoning to trainees may benefit from a common nomenclature of clinical reasoning terms.

  12. Thermospheric Density Model Including High-Latitude Energy Sources

    NASA Astrophysics Data System (ADS)

    Moe, O. K.; Moe, M. M.

    2006-12-01

    As was predicted long ago by Sydney Chapman, there is a major contribution to thermospheric energy from the magnetosphere at all times. The contribution of this magnetospheric energy source produces a neutral density bulge at high latitudes even during geomagnetically quiet times. We present an analytical, semi- empirical model of the global neutral density at such quiet times. The total density is expressed as the sum of two terms: The first term describes the combined effects of the solar ultra-violet heating and various other contributions like the semi-annual variation; the second term gives the contribution to the density associated with particle precipitation and joule heating coming from magnetospheric sources during times of low geomagnetic activity. The region of density enhancement at high latitudes is associated with the locations of the dayside cusps. Therefore the model produces a density distribution which depends on universal time as well as on altitude, latitude, local time, and the usual solar UV energy source. The numerical values of the parameters in the empirical model were originally determined 30 years ago from density data collected by the Bell-MESA accelerometer on the LOGACS satellite and the pressure gauge on the SPADES satellite. As an example of the model output, we show a Mercator projection of the global density distribution at 400 km altitude at 12 hours GMT in late May at a time of moderate solar activity and low geomagnetic activity. The parameters in the model can now be substantially improved by using recent advances like the latest description of the semi-annual variation and by incorporating the precise density measurements made by the accelerometers on board the CHAMP and GRACE satellites. In the original model, density values at times of high geomagnetic activity were included in the second density term. The parameters in that term can also be improved as accurate storm-time densities become available.

  13. Using Scaling for accurate stochastic macroweather forecasts (including the "pause")

    NASA Astrophysics Data System (ADS)

    Lovejoy, Shaun; del Rio Amador, Lenin

    2015-04-01

    At scales corresponding to the lifetimes of structures of planetary extent (about 5 - 10 days), atmospheric processes undergo a drastic "dimensional transition" from high frequency weather to lower frequency macroweather processes. While conventional GCM's generally well reproduce both the transition and the corresponding (scaling) statistics, due to their sensitive dependence on initial conditions, the role of the weather scale processes is to provide random perturbations to the macroweather processes. The main problem with GCM's is thus that their long term (control run, unforced) statistics converge to the GCM climate and this is somewhat different from the real climate. This is the motivation for using a stochastic model and exploiting the empirical scaling properties and past data to make a stochastic model. It turns out that macroweather intermittency is typically low (the multifractal corrections are small) so that they can be approximated by fractional Gaussian Noise (fGN) processes whose memory can be enormous. For example for annual forecasts, and using the observed global temperature exponent, even 50 years of global temperature data would only allow us to exploit 90% of the available memory (for ocean regions, the figure increases to 600 years). The only complication is that anthropogenic effects dominate the global statistics at time scales beyond about 20 years. However, these are easy to remove using the CO2 forcing as a linear surrogate for all the anthropogenic effects. Using this theoretical framework, we show how to make accurate stochastic macroweather forecasts. We illustrate this on monthly and annual scale series of global and northern hemisphere surface temperatures (including nearly perfect hindcasts of the "pause" in the warming since 1998). We obtain forecast skill nearly as high as the theoretical (scaling) predictability limits allow. These scaling hindcasts - using a single effective climate sensitivity and single scaling exponent are

  14. Laser surgery and medicine including photodynamic therapy in China today

    NASA Astrophysics Data System (ADS)

    Li, Junheng

    2000-10-01

    The development of laser medicine in China is correlated with the development of laser science in China. After the first Chinese laser, ruby laser came into being in 1961, Chinese medical scientists began to do the studies about laser medicine in the middle 1960s. For example, ruby laser was adopted for the retina coagulation experiment in 1965. Since 1970s, through the free choice of utilizing Co2, He-Ne, Nd:YAG argon, ruby lasers, laser surgery and medicine has been widely applied to the treatment for diseases of the eyes, ENT, dermatology, surgery, gynecology, tumors and diseases suitable to physical therapy or acupuncture with satisfactory effects. In June 1977, a nation-wide laser medicine symposium was held at Wuhan, Hubei Province with 200 participants including medical doctors and laser technologies from 23 provinces and municipal towns. Till the end of seventies, utilization of lasers has been extended to Nd glass laser, N laser and tunable dye lasers. The scope covered most of the clinical sections. After Dr. Thomas J. Dougherty developed the PDT for cancers in Roswell Park Memorial Institute in Buffalo in late 1970s and Professor Yoshihiro Hayata successfully applied the PDT in clinical treatment for lung cancer in 1980, Chinese pharmacists successfully produced the Chinese HpD and the first case of PDT, a lower eyelid basal cell carcinoma patient was treated with the Chinese laser equipment in 1981 in Beijing. Its success brought attention establishing a research group supported by the government in 1982. The members of the group consisted the experts on preclinical and clinical research, pharmaceutical chemistry, laser physicists and technologists. A systemic research on PDT was then carried out and obvious result was achieved. The step taken for PDT also accelerated the researchers on other kinds of laser medicine and surgery because the medical doctors had begun to master the knowledge about laser science. The prosperous situation of rapid

  15. Combination DMARD therapy including corticosteroids in early rheumatoid arthritis.

    PubMed

    Möttönen, T T; Hannonen, P J; Boers, M

    1999-01-01

    A number of reports indicating the growing acceptance of simultaneous therapy with multiple disease-modifying anti-rheumatic drugs (DMARDs), as well as the use of more aggressive treatment measures in the early phases of disease to combat rheumatoid arthritis (RA), have appeared during the last decade. However, only a few randomized controlled clinical trials have been conducted on the use of DMARD combinations in early RA. We review these trials in this article. In two separate one-year studies combination therapy with sulphasalazine (SSZ) and methotrexate (MTX) seemed to offer no benefits compared to either drug used as monotherapy. On the other hand, the DMARD combinations so far proven to be superior to single DMARDs have initially also included a corticosteroid component. In the COBRA study (Combinatietherapie Bij Reumatoide Artritis) the combination of SSZ (2 gm/day), MTX (7.5 mg/week for 40 weeks), and prednisolone (Prd) (initially 60 mg/day, tapered in 6 weekly steps to 7.5 mg/day and stopped after 28 weeks) compared to SSZ alone (2 gm/day) resulted in significantly better clinical outcomes at week 28. Although the difference in clinical response between the treatment arms was lost at week 58, the progression of joint damage remained statistically significantly slower at week 80 in the patients initially assigned to the combination therapy. Furthermore, in the FIN-RACo trial (Finnish Rheumatoid Arthritis Combination Therapy Trial), therapy using a "tailored-steps" strategy with SSZ (1-2 gm/day), MTX (7.5-1.5 mg/week), hydroxychloroquine (300 mg/day), and Prd (up to 10 mg/day) yielded a significantly increased remission rate and less peripheral joint damage at two years than the single DMARD treatment strategy (initially SSZ 2 gm/day), with or without Prd. Adverse effects in both study arms were comparable. Two additional preliminary reports (in abstract form) suggest that intensive local therapy in the form of intra-articular injections added to single or

  16. Practical uses for ecdysteroids in mammals including humans: an update

    PubMed Central

    Lafont, R.; Dinan, L.

    2003-01-01

    Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail. First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers. A second set of questions arose in fact much earlier with the pioneering “heterophylic” studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved. All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or “adaptogenic” properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses. It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances. Abbreviation: 20E 20-hydroxyecdysone 2d20E 2-deoxy-20-hydroxyecdysone 2dE 2-deoxyecdysone BAH bisacylhydrazine BmEcR Bombyx mori EcR CfEcR Choristoneura

  17. Including data quality concepts into the GEOSS Portal

    NASA Astrophysics Data System (ADS)

    Masó, Joan; Nust, Daniel; Diaz, Daniel; Closa, Guillem; Lush, Victoria; Zabala, Alaitz; Nativi, Stefano

    2014-05-01

    The EC FP7 GeoViQua project has focussed in including quality information into the GEO Portal to increase the visibility of it and increase trust in the GEOSS data products. GeoViQua has fully adopted and extended the ISO19115 metadata model and the XML encoding, incorporating the ISO19157 concepts as new XML elements (pending the official XML encoding) but adding new elements detected as missing aspects in the model. This makes possible an easy transition and coexistence of both models in the GEO portal. The GEOSS Portal enables the user to discover data introducing keywords and other filtering criteria. Once the list of results is returned, the user can read more about each result based on the metadata available in the GEOSS catalogues. In GeoViQua, we developed several metadata-based visualization tools through applying an XSLT allowing specialized visualization focused in different aspects. A provenance-based visualization tool emphasising the sequence of processes and data sources and its detailed description, has been integrated. It is also possible to assess the completeness of the metadata records using an extension of an initially developed by NOAA tool that is now enriched with quality indicators assessment. A metadata comparison tool is able to present metadata document side-by-side allowing parallel reading of the different metadata tags. Furthermore, numerical values are automatically compared and the best one is illuminated in green background colour, and a star plot and a parallel coordinates plot are used to easily show a graph with the best dataset as the large polygon and the highest line. Each summary result combines both producer metadata with the possibility for the user to submit feedback consisting in ratings, comments, expert reviews, links to documentation and new quality indicators. Previous feedback items, coming for other users are shown next to the summary producer metadata. Also the both summaries and extended descriptions of each

  18. Goldilocks models of higher-dimensional inflation (including modulus stabilization)

    NASA Astrophysics Data System (ADS)

    Burgess, C. P.; Enns, Jared J. H.; Hayman, Peter; Patil, Subodh P.

    2016-08-01

    We explore the mechanics of inflation within simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like inasmuch as they are just complicated enough to include a mechanism to stabilize the extra-dimensional size (or modulus), yet simple enough to solve explicitly the full extra-dimensional field equations using only simple tools. The solutions are not restricted to the effective 4D regime with H ll mKK (the latter referring to the characteristic mass splitting of the Kaluza-Klein excitations) because the full extra-dimensional Einstein equations are solved. This allows an exploration of inflationary physics in a controlled calculational regime away from the usual four-dimensional lamp-post. The inclusion of modulus stabilization is important because experience with string models teaches that this is usually what makes models fail: stabilization energies easily dominate the shallow potentials required by slow roll and so open up directions to evolve that are steeper than those of the putative inflationary direction. We explore (numerically and analytically) three representative kinds of inflationary scenarios within this simple setup. In one the radion is trapped in an inflaton-dependent local minimum whose non-zero energy drives inflation. Inflation ends as this energy relaxes to zero when the inflaton finds its own minimum. The other two involve power-law scaling solutions during inflation. One of these is a dynamical attractor whose features are relatively insensitive to initial conditions but whose slow-roll parameters cannot be arbitrarily small; the other is not an attractor but can roll much more slowly, until eventually transitioning to the attractor. The scaling solutions can satisfy H > mKK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict η simeq 0 and so r simeq 0.11 when ns simeq 0.96 and so

  19. Polarimetric Models of Circumstellar Discs Including Aggregate Dust Grains

    NASA Astrophysics Data System (ADS)

    Mohan, Mahesh

    output files and to apply a size distribution to the data. The second circumstellar disc investigated is the debris disc of the M dwarf star AU Mic. The disc was modelled, using the radiative transfer code Hyperion, based on F606W (HST) and JHK0-band (Keck II) scattered light observations and F606Wband polarized light observations. Initially, the disc is modelled as a two component structure using two grain types: compact silicate grains and porous dirty ice water. Both models are able to reproduce the observed SED and the F606W and H-band surface brightness profiles, but are unable to fit the observed F606W degree of polarization. Therefore, a more complex/realistic grain model was examined (ballistic aggregate particles). In addition, recent millimetre observations suggest the existence of a planetesimal belt < 3 AU from the central star. This belt is included in the BAM2 model and was successful in fitting the observed SED, F606W and H-band surface brightness and F606W polarization. These results demonstrate the limitations of spherical grain models and indicate the importance of modelling more realistic dust grains.

  20. Mantle Samples Included in Volcanic Rocks: Xenoliths and Diamonds

    NASA Astrophysics Data System (ADS)

    Pearson, D. G.; Canil, D.; Shirey, S. B.

    2003-12-01

    Occurrence and ClassificationFragments of the Earth's mantle are frequently transported to the surface via volcanic rocks that are dominantly alkaline in nature. These fragments range up to sizes in excess of 1 m across. The term "mantle xenoliths" or "mantle nodules" is applied to all rock and mineral inclusions of presumed mantle derivation that are found within host rocks of volcanic origin. The purpose of this contribution is to review the geochemistry of mantle xenoliths. For detailed petrological descriptions of individual locations and suites, together with their geological setting, the reader is referred to the major reference work by Nixon (1987).Despite peridotite xenoliths in basalts being recognized for several centuries and comparisons being made to lherzolite massifs (Lacroix, 1893), it was not until work on garnet peridotites and diamonds in kimberlites by Fermor (1913) and Wagner (1914) that such xenoliths were conceptually associated with a peridotite zone in the Earth beneath the crust, i.e., the zone that we now identify as the mantle. Mantle xenoliths provide snapshots of the lithospheric mantle beneath particular regions at the time of their eruption and hence are crucial direct evidence of the nature of the mantle beneath regions where no samples have been exposed by tectonic activity. As such, xenoliths are an essential compliment to tectonically exposed bodies of mantle (orogenic peridotites and ophiolites) that occur at plate boundaries (see Chapter 2.04). One obvious contrast between the mantle samples provided by xenoliths and those provided by peridotite massifs is the lack of field relationships available for xenoliths. Other drawbacks include the small size of many xenoliths. This makes accurate estimation of bulk compositions difficult and accentuates modal heterogeneities. The frequent infiltration of the host magma also complicates their chemical signature. Despite these drawbacks, xenoliths are of immense value, being the only

  1. Including Ideology

    ERIC Educational Resources Information Center

    Allan, Julie

    2013-01-01

    Ellen Brantlinger's paper, "Using ideology: cases of non-recognition of the politics of research and practice in special education" (Brantlinger, E. 1997. "Using ideology: Cases of nonrecognition of the politics of research and practice in special education." "Review of Educational Research" 67, no. 4: 425-59),…

  2. 76 FR 41521 - In the Matter of Certain Integrated Circuits, Chipsets, and Products Containing Same Including...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... COMMISSION In the Matter of Certain Integrated Circuits, Chipsets, and Products Containing Same Including... integrated circuits, chipsets, and products containing same including televisions by reason of infringement... integrated circuits, chipsets, and products containing same including televisions that infringe one or...

  3. 77 FR 34063 - Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... COMMISSION Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof... devices, including mobile phones and tablet computers, and components thereof by reason of infringement of... certain electronics devices, including mobile phones and tablet computers, and components thereof...

  4. 77 FR 27078 - Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof...

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    2012-05-08

    ... COMMISSION Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof... Trade Commission has received a complaint entitled Certain Electronic Devices, Including Mobile Phones... electronic devices, including mobile phones and tablet computers, and components thereof. The complaint...

  5. 76 FR 36154 - In the Matter of Certain Equipment for Communications Networks, Including Switches, Routers...

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    2011-06-21

    ... COMMISSION In the Matter of Certain Equipment for Communications Networks, Including Switches, Routers... United States after importation of certain equipment for communications networks, including switches... networks, including switches, routers, gateways, bridges, wireless access points, cable modems, IP...

  6. 76 FR 45878 - Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena...

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    2011-08-01

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena Park, CA; Alticor, Inc., Including Access Business Group International LLC and..., Ada, MI; Alticor, Inc., Including Access Business Group International LLC and Amway...

  7. 75 FR 32221 - Alticor, Inc., Including Access Business Group International, LLC, and Amway Corporation...

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    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International, LLC, and..., applicable to workers of Alticor, Inc., including Access Business Group International, LLC and Amway... location of Alticor, Inc., including Access Business Group International, LLC and Amway Corporation....

  8. 77 FR 18860 - Certain Consumer Electronics, Including Mobile Phones and Tablets; Notice of Receipt of Complaint...

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    2012-03-28

    ... COMMISSION Certain Consumer Electronics, Including Mobile Phones and Tablets; Notice of Receipt of Complaint... complaint entitled Certain Consumer Electronics, Including Mobile Phones and Tablets, DN 2885; the... importation of certain consumer electronics, including mobile phones and tablets. The complaint names...

  9. 75 FR 22630 - Nautilus, Inc., Currently Known as Med-Fit Systems Incorporated, Commercial Division, Including...

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    2010-04-29

    ..., Commercial Division, Including On-Site Workers From Select Staffing, Independence, VA; Amended Certification... Nautilus, Inc., Commercial Division, including on-site leased workers from Select Staffing,...

  10. 76 FR 4724 - Emerson Transportation Division, a Division of Emerson Electric, Including Workers Located...

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    2011-01-26

    ..., Including Workers Located Throughout the United States; Bridgeton, MO; Amended Certification Regarding... Emerson Transportation Division, a division of Emerson Electric, including workers located throughout...

  11. Composite materials and bodies including silicon carbide and titanium diboride and methods of forming same

    DOEpatents

    Lillo, Thomas M.; Chu, Henry S.; Harrison, William M.; Bailey, Derek

    2013-01-22

    Methods of forming composite materials include coating particles of titanium dioxide with a substance including boron (e.g., boron carbide) and a substance including carbon, and reacting the titanium dioxide with the substance including boron and the substance including carbon to form titanium diboride. The methods may be used to form ceramic composite bodies and materials, such as, for example, a ceramic composite body or material including silicon carbide and titanium diboride. Such bodies and materials may be used as armor bodies and armor materials. Such methods may include forming a green body and sintering the green body to a desirable final density. Green bodies formed in accordance with such methods may include particles comprising titanium dioxide and a coating at least partially covering exterior surfaces thereof, the coating comprising a substance including boron (e.g., boron carbide) and a substance including carbon.

  12. Momentum relation and classical limit in the future-not-included complex action theory

    NASA Astrophysics Data System (ADS)

    Nagao, Keiichi; Nielsen, Holger Bech

    2013-07-01

    Studying the time development of the expectation value in the future-not-included complex action theory, we point out that the momentum relation (the relation analogous to p=frac {partial L}{partial dot {q}}), which was derived via the Feynman path integral and was shown to be correct in the future-included theory in our previous papers, is not valid in the future-not-included theory. We provide the correct momentum relation in the future-not-included theory, and argue that the future-not-included classical theory is described by a certain real action. In addition, we provide another way to understand the time development of the future-not-included theory by utilizing the future-included theory. Furthermore, properly applying the method used in our previous paper to the future-not-included theory by introducing a formal Lagrangian, we derive the correct momentum relation in the future-not-included theory.

  13. 76 FR 19467 - Weyerhaeuser Company, Corporate Headquarters Including On-Site Leased Workers From Volt Services...

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    ... Employment and Training Administration Weyerhaeuser Company, Corporate Headquarters Including On-Site Leased... to workers of Weyerhaeuser Company, Corporate Headquarters, including on-site leased workers from Volt Services, Adecco, and Manpower, Federal Way, Washington. The workers supply corporate...

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    ... Employment and Training Administration Hewlett-Packard Company Division of Corporate Administration and... Division of Corporate Administration and Shared Services Including On- Site Leased Workers From Manpower... Company, Division of Corporate Administration and Shared Services, including on- site leased workers...

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    ... COMMISSION Certain Integrated Circuits, Chipsets, and Products Containing Same Including Televisions, Receipt... Commission has received a complaint entitled In Re Certain Integrated Circuits, Chipsets, And Products... importation of certain integrated circuits, chipsets, and products containing same including televisions....

  16. 76 FR 34101 - In the Matter of Certain Integrated Circuits, Chipsets, and Products Containing Same Including...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of Certain Integrated Circuits, Chipsets, and Products Containing Same Including... integrated circuits, chipsets, and products containing same including televisions, media players, and...

  17. 76 FR 27366 - Blue Heron Paper Company, Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

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    ... Employment and Training Administration Blue Heron Paper Company, Including Workers Whose Unemployment... reported under a separated unemployment insurance (UI) tax account under the name Barrett Business Services... issued as follows: All workers of Blue Heron Paper Company, including workers whose...

  18. 75 FR 22630 - Vital Signs Minnesota, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

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    ... Employment and Training Administration Vital Signs Minnesota, Inc., Including Workers Whose Unemployment... separate unemployment insurance (UI) tax account under the name Biomedical Dynamics Corporation... unemployment insurance (UI) wages are paid through Biomedical Dynamics Corporation, including on-site...

  19. 75 FR 55613 - General Motors Corporation, Renaissance Center, Including On-Site Leased Workers From Accretive...

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    2010-09-13

    ... Employment and Training Administration General Motors Corporation, Renaissance Center, Including On-Site... of General Motors Corporation, Renaissance Center, including on-site leased workers from Accretive... location of General Motors Corporation, Renaissance Center. The Department has determined that...

  20. 76 FR 43349 - General Motors Corporation, Renaissance Center, including On-Site Leased Workers From Accretive...

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    2011-07-20

    ... Employment and Training Administration General Motors Corporation, Renaissance Center, including On-Site... 23, 2010, applicable to workers of General Motors Corporation, Renaissance Center, including on-site... Detroit, Michigan location of General Motors Corporation, Renaissance Center. The Department...