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Sample records for independent-set optimization transitions

  1. Network Conduciveness with Application to the Graph-Coloring and Independent-Set Optimization Transitions

    PubMed Central

    Barbosa, Valmir C.

    2010-01-01

    Background Given an undirected graph, we consider the two problems of combinatorial optimization, which ask that its chromatic and independence numbers be found. Although both problems are NP-hard, when either one is solved on the incrementally denser graphs of a random sequence, at certain critical values of the number of edges, it happens that the transition to the next value causes optimal solutions to be obtainable substantially more easily than right before it. Methodology/Principal Findings We introduce the notion of a network's conduciveness, a probabilistically interpretable measure of how the network's structure allows it to be conducive to roaming agents, in certain conditions, from one portion of the network to another. We demonstrate that the performance jumps of graph coloring and independent sets at the critical-value transitions in the number of edges can be understood by resorting to the network that represents the solution space of the problems for each graph and examining its conduciveness between the non-optimal solutions and the optimal ones. Right past each transition, this network becomes strikingly more conducive in the direction of the optimal solutions than it was just before it, while at the same time becoming less conducive in the opposite direction. Conclusions/Significance Network conduciveness provides a useful conceptual framework for explaining the performance jumps associated with graph coloring and independent sets. We believe it may also become instrumental in helping clarify further issues related to NP-hardness that remain poorly understood. Additionally, it may become useful also in other areas in which network theory has a role to play. PMID:20628597

  2. Statistical mechanics of maximal independent sets

    NASA Astrophysics Data System (ADS)

    Dall'Asta, Luca; Pin, Paolo; Ramezanpour, Abolfazl

    2009-12-01

    The graph theoretic concept of maximal independent set arises in several practical problems in computer science as well as in game theory. A maximal independent set is defined by the set of occupied nodes that satisfy some packing and covering constraints. It is known that finding minimum and maximum-density maximal independent sets are hard optimization problems. In this paper, we use cavity method of statistical physics and Monte Carlo simulations to study the corresponding constraint satisfaction problem on random graphs. We obtain the entropy of maximal independent sets within the replica symmetric and one-step replica symmetry breaking frameworks, shedding light on the metric structure of the landscape of solutions and suggesting a class of possible algorithms. This is of particular relevance for the application to the study of strategic interactions in social and economic networks, where maximal independent sets correspond to pure Nash equilibria of a graphical game of public goods allocation.

  3. Maximum independent set on diluted triangular lattices

    NASA Astrophysics Data System (ADS)

    Fay, C. W., IV; Liu, J. W.; Duxbury, P. M.

    2006-05-01

    Core percolation and maximum independent set on random graphs have recently been characterized using the methods of statistical physics. Here we present a statistical physics study of these problems on bond diluted triangular lattices. Core percolation critical behavior is found to be consistent with the standard percolation values, though there are strong finite size effects. A transfer matrix method is developed and applied to find accurate values of the density and degeneracy of the maximum independent set on lattices of limited width but large length. An extrapolation of these results to the infinite lattice limit yields high precision results, which are tabulated. These results are compared to results found using both vertex based and edge based local probability recursion algorithms, which have proven useful in the analysis of hard computational problems, such as the satisfiability problem.

  4. Counting independent sets using the Bethe approximation

    SciTech Connect

    Chertkov, Michael; Chandrasekaran, V; Gamarmik, D; Shah, D; Sin, J

    2009-01-01

    The authors consider the problem of counting the number of independent sets or the partition function of a hard-core model in a graph. The problem in general is computationally hard (P hard). They study the quality of the approximation provided by the Bethe free energy. Belief propagation (BP) is a message-passing algorithm can be used to compute fixed points of the Bethe approximation; however, BP is not always guarantee to converge. As the first result, they propose a simple message-passing algorithm that converges to a BP fixed pont for any grapy. They find that their algorithm converges within a multiplicative error 1 + {var_epsilon} of a fixed point in {Omicron}(n{sup 2}E{sup -4} log{sup 3}(nE{sup -1})) iterations for any bounded degree graph of n nodes. In a nutshell, the algorithm can be thought of as a modification of BP with 'time-varying' message-passing. Next, they analyze the resulting error to the number of independent sets provided by such a fixed point of the Bethe approximation. Using the recently developed loop calculus approach by Vhertkov and Chernyak, they establish that for any bounded graph with large enough girth, the error is {Omicron}(n{sup -{gamma}}) for some {gamma} > 0. As an application, they find that for random 3-regular graph, Bethe approximation of log-partition function (log of the number of independent sets) is within o(1) of corret log-partition - this is quite surprising as previous physics-based predictions were expecting an error of o(n). In sum, their results provide a systematic way to find Bethe fixed points for any graph quickly and allow for estimating error in Bethe approximation using novel combinatorial techniques.

  5. Optimal BLS: Optimizing transit-signal detection for Keplerian dynamics

    NASA Astrophysics Data System (ADS)

    Ofir, Aviv

    2015-08-01

    Transit surveys, both ground- and space-based, have already accumulated a large number of light curves that span several years. We optimize the search for transit signals for both detection and computational efficiencies by assuming that the searched systems can be described by Keplerian, and propagating the effects of different system parameters to the detection parameters. Importnantly, we mainly consider the information content of the transit signal and not any specific algorithm - and use BLS (Kovács, Zucker, & Mazeh 2002) just as a specific example.We show that the frequency information content of the light curve is primarily determined by the duty cycle of the transit signal, and thus the optimal frequency sampling is found to be cubic and not linear. Further optimization is achieved by considering duty-cycle dependent binning of the phased light curve. By using the (standard) BLS, one is either fairly insensitive to long-period planets or less sensitive to short-period planets and computationally slower by a significant factor of ~330 (for a 3 yr long dataset). We also show how the physical system parameters, such as the host star's size and mass, directly affect transit detection. This understanding can then be used to optimize the search for every star individually.By considering Keplerian dynamics explicitly rather than implicitly one can optimally search the transit signal parameter space. The presented Optimal BLS enhances the detectability of both very short and very long period planets, while allowing such searches to be done with much reduced resources and time. The Matlab/Octave source code for Optimal BLS is made available.

  6. Phase transitions in Pareto optimal complex networks

    NASA Astrophysics Data System (ADS)

    Seoane, Luís F.; Solé, Ricard

    2015-09-01

    The organization of interactions in complex systems can be described by networks connecting different units. These graphs are useful representations of the local and global complexity of the underlying systems. The origin of their topological structure can be diverse, resulting from different mechanisms including multiplicative processes and optimization. In spatial networks or in graphs where cost constraints are at work, as it occurs in a plethora of situations from power grids to the wiring of neurons in the brain, optimization plays an important part in shaping their organization. In this paper we study network designs resulting from a Pareto optimization process, where different simultaneous constraints are the targets of selection. We analyze three variations on a problem, finding phase transitions of different kinds. Distinct phases are associated with different arrangements of the connections, but the need of drastic topological changes does not determine the presence or the nature of the phase transitions encountered. Instead, the functions under optimization do play a determinant role. This reinforces the view that phase transitions do not arise from intrinsic properties of a system alone, but from the interplay of that system with its external constraints.

  7. Optimal guidance for the space shuttle transition.

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.

    1972-01-01

    A guidance method for the space shuttle's transition from hypersonic entry to subsonic cruising flight is presented. The method evolves from a numerical trajectory optimization technique in which kinetic energy and total energy (per unit weight) replace velocity and time in the dynamic equations. This allows the open end-time problem to be transformed to one of fixed terminal energy. In its ultimate form, 'E-Guidance' obtains energy balance (including dynamic-pressure-rate damping) and path length control by angle-of-attack modulation and cross-range control by roll angle modulation. The guidance functions also form the basis for a pilot display of instantaneous maneuver limits and destination. Numerical results illustrate the E-Guidance concept and the optimal trajectories on which it is based.

  8. Optimal guidance for the space shuttle transition

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.

    1974-01-01

    A guidance method for the space shuttle's transition from hypersonic entry to subsonic cruising flight is presented. The method evolves from a numerical trajectory optimization technique in which kinetic energy and total energy (per unit weight) replace velocity and time in the dynamic equations. This allows the open end-time problem to be transformed to one of fixed terminal energy. In its ultimate form, E-Guidance obtains energy balance (including dynamic-pressure-rate damping) and path length control by angle-of-attack modulation and cross-range control by roll angle modulation. The guidance functions also form the basis for a pilot display of instantaneous maneuver limits and destination. Numerical results illustrate the E-Guidance concept and the optimal trajectories on which it is based.

  9. Optimal guidance for the space shuttle transition

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.

    1972-01-01

    A guidance method for the space shuttle's transition from hypersonic entry to subsonic cruising flight is presented. The method evolves from a numerical trajectory optimization technique in which kinetic energy and total energy (per unit weight) replace velocity and time in the dynamic equations. This allows the open end-time problem to be transformed to one of fixed terminal energy. In its ultimate form, E-Guidance obtains energy balance (including dynamic-pressure-rate damping) and path length control by angle-of-attack modulation and cross-range control by roll angle modulation. The guidance functions also form the basis for a pilot display of instantaneous maneuver limits and destination. Numerical results illustrate the E-Guidance concept and the optimal trajectories on which it is based.

  10. Beyond Maximum Independent Set: AN Extended Model for Point-Feature Label Placement

    NASA Astrophysics Data System (ADS)

    Haunert, Jan-Henrik; Wolff, Alexander

    2016-06-01

    Map labeling is a classical problem of cartography that has frequently been approached by combinatorial optimization. Given a set of features in the map and for each feature a set of label candidates, a common problem is to select an independent set of labels (that is, a labeling without label-label overlaps) that contains as many labels as possible and at most one label for each feature. To obtain solutions of high cartographic quality, the labels can be weighted and one can maximize the total weight (rather than the number) of the selected labels. We argue, however, that when maximizing the weight of the labeling, interdependences between labels are insufficiently addressed. Furthermore, in a maximum-weight labeling, the labels tend to be densely packed and thus the map background can be occluded too much. We propose extensions of an existing model to overcome these limitations. Since even without our extensions the problem is NP-hard, we cannot hope for an efficient exact algorithm for the problem. Therefore, we present a formalization of our model as an integer linear program (ILP). This allows us to compute optimal solutions in reasonable time, which we demonstrate for randomly generated instances.

  11. Optimized pulse sequences for suppressing unwanted transitions in quantum systems

    SciTech Connect

    Schroeder, C. A.; Agarwal, G. S.

    2011-01-15

    We investigate the nature of the pulse sequence so that unwanted transitions in quantum systems can be inhibited optimally. For this purpose we show that the sequence of pulses proposed by Uhrig [Phys. Rev. Lett. 98, 100504 (2007)] in the context of inhibition of environmental dephasing effects is optimal. We derive exact results for inhibiting the transitions and confirm the results numerically. We posit a very significant improvement by usage of the Uhrig sequence over an equidistant sequence in decoupling a quantum system from unwanted transitions. The physics of inhibition is the destructive interference between transition amplitudes before and after each pulse.

  12. Quantum optimal control theory applied to transitions in diatomic molecules

    NASA Astrophysics Data System (ADS)

    Lysebo, Marius; Veseth, Leif

    2014-12-01

    Quantum optimal control theory is applied to control electric dipole transitions in a real multilevel system. The specific system studied in the present work is comprised of a multitude of hyperfine levels in the electronic ground state of the OH molecule. Spectroscopic constants are used to obtain accurate energy eigenstates and electric dipole matrix elements. The goal is to calculate the optimal time-dependent electric field that yields a maximum of the transition probability for a specified initial and final state. A further important objective was to study the detailed quantum processes that take place during such a prescribed transition in a multilevel system. Two specific transitions are studied in detail. The computed optimal electric fields as well as the paths taken through the multitude of levels reveal quite interesting quantum phenomena.

  13. Optimal Control of Transitions between Nonequilibrium Steady States

    PubMed Central

    Zulkowski, Patrick R.; Sivak, David A.; DeWeese, Michael R.

    2013-01-01

    Biological systems fundamentally exist out of equilibrium in order to preserve organized structures and processes. Many changing cellular conditions can be represented as transitions between nonequilibrium steady states, and organisms have an interest in optimizing such transitions. Using the Hatano-Sasa Y-value, we extend a recently developed geometrical framework for determining optimal protocols so that it can be applied to systems driven from nonequilibrium steady states. We calculate and numerically verify optimal protocols for a colloidal particle dragged through solution by a translating optical trap with two controllable parameters. We offer experimental predictions, specifically that optimal protocols are significantly less costly than naive ones. Optimal protocols similar to these may ultimately point to design principles for biological energy transduction systems and guide the design of artificial molecular machines. PMID:24386112

  14. Optimized pulse sequences for suppressing unwanted transitions in quantum systems

    NASA Astrophysics Data System (ADS)

    Schroeder, C. A.; Agarwal, G. S.

    2011-01-01

    We investigate the nature of the pulse sequence so that unwanted transitions in quantum systems can be inhibited optimally. For this purpose we show that the sequence of pulses proposed by Uhrig [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.98.100504 98, 100504 (2007)] in the context of inhibition of environmental dephasing effects is optimal. We derive exact results for inhibiting the transitions and confirm the results numerically. We posit a very significant improvement by usage of the Uhrig sequence over an equidistant sequence in decoupling a quantum system from unwanted transitions. The physics of inhibition is the destructive interference between transition amplitudes before and after each pulse.

  15. Optimal and robust control of transition

    NASA Technical Reports Server (NTRS)

    Bewley, T. R.; Agarwal, R.

    1996-01-01

    Optimal and robust control theories are used to determine feedback control rules that effectively stabilize a linearly unstable flow in a plane channel. Wall transpiration (unsteady blowing/suction) with zero net mass flux is used as the control. Control algorithms are considered that depend both on full flowfield information and on estimates of that flowfield based on wall skin-friction measurements only. The development of these control algorithms accounts for modeling errors and measurement noise in a rigorous fashion; these disturbances are considered in both a structured (Gaussian) and unstructured ('worst case') sense. The performance of these algorithms is analyzed in terms of the eigenmodes of the resulting controlled systems, and the sensitivity of individual eigenmodes to both control and observation is quantified.

  16. Optimal disturbances and bypass transition in boundary layers

    NASA Astrophysics Data System (ADS)

    Andersson, Paul; Berggren, Martin; Henningson, Dan S.

    1999-01-01

    Streamwise streaks are ubiquitous in transitional boundary layers, particularly when subjected to high levels of free-stream turbulence. Using the steady boundary-layer approximation, the upstream disturbances experiencing maximum spatial energy growth are numerically calculated. The calculations use techniques commonly employed when solving optimal-control problems for distributed parameter systems. The calculated optimal disturbances consist of streamwise vortices developing into streamwise streaks. The maximum spatial energy growth was found to scale linearly with the distance from the leading edge. Based on these results, a simple model for prediction of transition location is proposed. Available experiments have been used to correlate the single constant appearing in the model.

  17. Transition state ensemble optimization for reactions of arbitrary complexity

    NASA Astrophysics Data System (ADS)

    Zinovjev, Kirill; Tuñón, Iñaki

    2015-10-01

    In the present work, we use Variational Transition State Theory (VTST) to develop a practical method for transition state ensemble optimization by looking for an optimal hyperplanar dividing surface in a space of meaningful trial collective variables. These might be interatomic distances, angles, electrostatic potentials, etc. Restrained molecular dynamics simulations are used to obtain on-the-fly estimates of ensemble averages that guide the variations of the hyperplane maximizing the transmission coefficient. A central result of our work is an expression that quantitatively estimates the importance of the coordinates used for the localization of the transition state ensemble. Starting from an arbitrarily large set of trial coordinates, one can distinguish those that are indeed essential for the advance of the reaction. This facilitates the use of VTST as a practical theory to study reaction mechanisms of complex processes. The technique was applied to the reaction catalyzed by an isochorismate pyruvate lyase. This reaction involves two simultaneous chemical steps and has a shallow transition state region, making it challenging to define a good reaction coordinate. Nevertheless, the hyperplanar transition state optimized in the space of 18 geometrical coordinates provides a transmission coefficient of 0.8 and a committor histogram well-peaked about 0.5, proving the strength of the method. We have also tested the approach with the study of the NaCl dissociation in aqueous solution, a stringest test for a method based on transition state theory. We were able to find essential degrees of freedom consistent with the previous studies and to improve the transmission coefficient with respect to the value obtained using solely the NaCl distance as the reaction coordinate.

  18. Preferred and Energetically Optimal Transition Speeds During Backward Human Locomotion

    PubMed Central

    Hreljac, Alan; Imamura, Rodney; Escamilla, Rafael F.; Casebolt, Jeffrey; Sison, Mitell

    2005-01-01

    Some aspects of backward locomotion are similar to forward locomotion, while other aspects are not related to their forward counterpart. The backward preferred transition speed (BPTS) has never been directly compared to the energetically optimal transition speed (EOTS), nor has it been compared to the preferred transition speed (PTS) during forward locomotion. The purpose of this study was to determine whether the BPTS occurs at the EOTS, and to examine the relationship between the backward and forward preferred gait transition speeds. The preferred backward and forward transition speeds of 12 healthy, young subjects (7 males, 5 females) were determined after subjects were familiarized with forward and backward treadmill locomotion. On a subsequent day, subjects walked backward at speeds of 70, 80, 90, 100, and 110% of the BPTS and ran backward at speeds of 60, 75, 90, 100, and 120% of the BPTS while VO2 and RPE data were collected. After subtracting standing VO2, exercise VO2 was normalized to body mass and speed. For each subject, energy-speed curves for walking and running were fit to the normalized data points. The intersection of these curves was defined as the EOTS which was compared to the BPTS using a paired t-test (p < 0.05). RPE and VO2 at the BPTS were also compared between walking and running conditions, and the correlation between BPTS and PTS was calculated. The EOTS (1.85 ± 0.09 m·s-1) was significantly greater than the BPTS (1.63 ± 0.11 m·s-1). Even though RPE was equal for walking and running at the BPTS, VO2 was significantly greater when running. There was a strong correlation (r = 0.82) between the BPTS and the PTS. Similar to forward locomotion, the determinants of the BPTS must include factors other than metabolic energy. The gait transition during backward locomotion exhibits several similarities to its forward counterpart. Key Points The backward preferred transition speed (1.63 ± 0.11 m·s-1) was significantly less than the

  19. Thermal conductivity switch: Optimal semiconductor/metal melting transition

    NASA Astrophysics Data System (ADS)

    Kim, Kwangnam; Kaviany, Massoud

    2016-10-01

    Scrutinizing distinct solid/liquid (s /l ) and solid/solid (s /s ) phase transitions (passive transitions) for large change in bulk (and homogenous) thermal conductivity, we find the s /l semiconductor/metal (S/M) transition produces the largest dimensionless thermal conductivity switch (TCS) figure of merit ZTCS (change in thermal conductivity divided by smaller conductivity). At melting temperature, the solid phonon and liquid molecular thermal conductivities are comparable and generally small, so the TCS requires localized electron solid and delocalized electron liquid states. For cyclic phase reversibility, the congruent phase transition (no change in composition) is as important as the thermal transport. We identify X Sb and X As (X =Al , Cd, Ga, In, Zn) and describe atomic-structural metrics for large ZTCS, then show the superiority of S/M phonon- to electron-dominated transport melting transition. We use existing experimental results and theoretical and ab initio calculations of the related properties for both phases (including the Kubo-Greenwood and Bridgman formulations of liquid conductivities). The 5 p orbital of Sb contributes to the semiconductor behavior in the solid-phase band gap and upon disorder and bond-length changes in the liquid phase this changes to metallic, creating the large contrast in thermal conductivity. The charge density distribution, electronic localization function, and electron density of states are used to mark this S/M transition. For optimal TCS, we examine the elemental selection from the transition, basic, and semimetals and semiconductor groups. For CdSb, addition of residual Ag suppresses the bipolar conductivity and its ZTCS is over 7, and for Zn3Sb2 it is expected to be over 14, based on the structure and transport properties of the better-known β -Zn4Sb3 . This is the highest ZTCS identified. In addition to the metallic melting, the high ZTCS is due to the electron-poor nature of II-V semiconductors, leading to the

  20. GreedyMAX-type Algorithms for the Maximum Independent Set Problem

    NASA Astrophysics Data System (ADS)

    Borowiecki, Piotr; Göring, Frank

    A maximum independent set problem for a simple graph G = (V,E) is to find the largest subset of pairwise nonadjacent vertices. The problem is known to be NP-hard and it is also hard to approximate. Within this article we introduce a non-negative integer valued function p defined on the vertex set V(G) and called a potential function of a graph G, while P(G) = max v ∈ V(G) p(v) is called a potential of G. For any graph P(G) ≤ Δ(G), where Δ(G) is the maximum degree of G. Moreover, Δ(G) - P(G) may be arbitrarily large. A potential of a vertex lets us get a closer insight into the properties of its neighborhood which leads to the definition of the family of GreedyMAX-type algorithms having the classical GreedyMAX algorithm as their origin. We establish a lower bound 1/(P + 1) for the performance ratio of GreedyMAX-type algorithms which favorably compares with the bound 1/(Δ + 1) known to hold for GreedyMAX. The cardinality of an independent set generated by any GreedyMAX-type algorithm is at least sum_{vin V(G)} (p(v)+1)^{-1}, which strengthens the bounds of Turán and Caro-Wei stated in terms of vertex degrees.

  1. Soil Vapor Extraction System Optimization, Transition, and Closure Guidance

    SciTech Connect

    Truex, Michael J.; Becker, Dave; Simon, Michelle A.; Oostrom, Martinus; Rice, Amy K.; Johnson, Christian D.

    2013-02-08

    Soil vapor extraction (SVE) is a prevalent remediation approach for volatile contaminants in the vadose zone. A diminishing rate of contaminant extraction over time is typically observed due to 1) diminishing contaminant mass, and/or 2) slow rates of removal for contamination in low-permeability zones. After a SVE system begins to show indications of diminishing contaminant removal rate, SVE performance needs to be evaluated to determine whether the system should be optimized, terminated, or transitioned to another technology to replace or augment SVE. This guidance specifically addresses the elements of this type of performance assessment. While not specifically presented, the approach and analyses in this guidance could also be applied at the onset of remediation selection for a site as a way to evaluate current or future impacts to groundwater from vadose zone contamination. The guidance presented here builds from existing guidance for SVE design, operation, optimization, and closure from the U.S. Environmental Protection Agency, U.S. Army Corps of Engineers, and the Air Force Center for Engineering and the Environment. The purpose of the material herein is to clarify and focus on the specific actions and decisions related to SVE optimization, transition, and/or closure.

  2. Transition Delay in Hypersonic Boundary Layers via Optimal Perturbations

    NASA Technical Reports Server (NTRS)

    Paredes, Pedro; Choudhari, Meelan M.; Li, Fei

    2016-01-01

    The effect of nonlinear optimal streaks on disturbance growth in a Mach 6 axisymmetric flow over a 7deg half-angle cone is investigated in an e ort to expand the range of available techniques for transition control. Plane-marching parabolized stability equations are used to characterize the boundary layer instability in the presence of azimuthally periodic streaks. The streaks are observed to stabilize nominally planar Mack mode instabilities, although oblique Mack mode disturbances are destabilized. Experimentally measured transition onset in the absence of any streaks correlates with an amplification factor of N = 6 for the planar Mack modes. For high enough streak amplitudes, the transition threshold of N = 6 is not reached by the Mack mode instabilities within the length of the cone, but subharmonic first mode instabilities, which are destabilized by the presence of the streaks, reach N = 6 near the end of the cone. These results suggest a passive flow control strategy of using micro vortex generators to induce streaks that would delay transition in hypersonic boundary layers.

  3. Simple neural-like p systems for maximal independent set selection.

    PubMed

    Xu, Lei; Jeavons, Peter

    2013-06-01

    Membrane systems (P systems) are distributed computing models inspired by living cells where a collection of processors jointly achieves a computing task. The problem of maximal independent set (MIS) selection in a graph is to choose a set of nonadjacent nodes to which no further nodes can be added. In this letter, we design a class of simple neural-like P systems to solve the MIS selection problem efficiently in a distributed way. This new class of systems possesses two features that are attractive for both distributed computing and membrane computing: first, the individual processors do not need any information about the overall size of the graph; second, they communicate using only one-bit messages.

  4. A numerical scheme for optimal transition paths of stochastic chemical kinetic systems

    SciTech Connect

    Liu Di

    2008-10-01

    We present a new framework for finding the optimal transition paths of metastable stochastic chemical kinetic systems with large system size. The optimal transition paths are identified to be the most probable paths according to the Large Deviation Theory of stochastic processes. Dynamical equations for the optimal transition paths are derived using the variational principle. A modified Minimum Action Method (MAM) is proposed as a numerical scheme to solve the optimal transition paths. Applications to Gene Regulatory Networks such as the toggle switch model and the Lactose Operon Model in Escherichia coli are presented as numerical examples.

  5. Density functional theory optimized basis sets for gradient corrected functionals: 3d transition metal systems.

    PubMed

    Calaminici, Patrizia; Janetzko, Florian; Köster, Andreas M; Mejia-Olvera, Roberto; Zuniga-Gutierrez, Bernardo

    2007-01-28

    Density functional theory optimized basis sets for gradient corrected functionals for 3d transition metal atoms are presented. Double zeta valence polarization and triple zeta valence polarization basis sets are optimized with the PW86 functional. The performance of the newly optimized basis sets is tested in atomic and molecular calculations. Excitation energies of 3d transition metal atoms, as well as electronic configurations, structural parameters, dissociation energies, and harmonic vibrational frequencies of a large number of molecules containing 3d transition metal elements, are presented. The obtained results are compared with available experimental data as well as with other theoretical data from the literature.

  6. Fibonacci and Nonadjacent Numbers on the Characterization of Fibonacci Numbers as Maximal Independent Sets of Vertices of Certain Trees.

    DTIC Science & Technology

    1987-08-11

    A183 M FIN MCI AM NONADJACENT NUIERS ON THE CHRACTERIZRTION OF FIBONACCI MU.. (U) GEORGIA UNIV ATHENS DEPT OF CNENISTRY S EL-IASIL 11 AUG 67 TR-50...Code 4007001-6 0Technical Report No. 50 Fibonacci and Nonadjacent Numbers On the Characterization of Fibonacci Numbers as Maximal Independent Sets of...aide It necessary and Identify’ by block nuinbet) Graph Theory Fibonacci Numbers Nonadjacent Numbers King Patterns 15anzen inWdrnrarhnnc 20r ANSTRAC lCni

  7. On the optimality equation for average cost Markov control processes with Feller transition probabilities

    NASA Astrophysics Data System (ADS)

    Jaskiewicz, Anna; Nowak, Andrzej S.

    2006-04-01

    We consider Markov control processes with Borel state space and Feller transition probabilities, satisfying some generalized geometric ergodicity conditions. We provide a new theorem on the existence of a solution to the average cost optimality equation.

  8. Feelings of Optimism and Pessimism in Japanese Students' Transition to Junior High School.

    ERIC Educational Resources Information Center

    Koizumi, Reizo

    1995-01-01

    Generalized future expectancies of personal life success (optimism) and failure (pessimism) were examined in a cross-sectional study, with Japanese fifth- through ninth-grade students (n=584). Average optimism scores were lower and average pessimism scores were higher after the transition to junior high school. (JBJ)

  9. Transit telescope designs optimized for multiple object spectroscopy with fibers

    NASA Technical Reports Server (NTRS)

    Angel, J. R. P.

    1982-01-01

    Instruments to simultaneously study the spectra of many objects in the field of view of a telescope can be made using fused silica fibers. The spectrograph at the 2.3m telescope of the University of Arizona has been modified for such operation, and is used routinely to study the dynamics of galaxy clusters. Consideration has been given to how the multifiber technique can best be used to obtain spectra of the many faint objects identified by deep transit survey instruments and new space and radio telescopes. A transit survey such as that planned by McGraw et al. (1980), with CCDs at the focus of a 2m transit telescope, will identify objects down to 24th magnitude, and down to 22nd magnitude will give very complete data on variability and optical energy distribution. A telescope with much larger aperture is required for spectroscopic follow up. It is suggested that large telescopes dedicated to this type of work can be made and operated for only a fraction of the cost of a general-purpose telescope.

  10. Advanced Nuclear Fuel Cycle Transitions: Optimization, Modeling Choices, and Disruptions

    NASA Astrophysics Data System (ADS)

    Carlsen, Robert W.

    Many nuclear fuel cycle simulators have evolved over time to help understan the nuclear industry/ecosystem at a macroscopic level. Cyclus is one of th first fuel cycle simulators to accommodate larger-scale analysis with it liberal open-source licensing and first-class Linux support. Cyclus also ha features that uniquely enable investigating the effects of modeling choices o fuel cycle simulators and scenarios. This work is divided into thre experiments focusing on optimization, effects of modeling choices, and fue cycle uncertainty. Effective optimization techniques are developed for automatically determinin desirable facility deployment schedules with Cyclus. A novel method fo mapping optimization variables to deployment schedules is developed. Thi allows relationships between reactor types and scenario constraints to b represented implicitly in the variable definitions enabling the usage o optimizers lacking constraint support. It also prevents wasting computationa resources evaluating infeasible deployment schedules. Deployed power capacit over time and deployment of non-reactor facilities are also included a optimization variables There are many fuel cycle simulators built with different combinations o modeling choices. Comparing results between them is often difficult. Cyclus flexibility allows comparing effects of many such modeling choices. Reacto refueling cycle synchronization and inter-facility competition among othe effects are compared in four cases each using combinations of fleet of individually modeled reactors with 1-month or 3-month time steps. There are noticeable differences in results for the different cases. The larges differences occur during periods of constrained reactor fuel availability This and similar work can help improve the quality of fuel cycle analysi generally There is significant uncertainty associated deploying new nuclear technologie such as time-frames for technology availability and the cost of buildin advanced reactors

  11. Subcritical transition scenarios via linear and nonlinear localized optimal perturbations in plane Poiseuille flow

    NASA Astrophysics Data System (ADS)

    Farano, Mirko; Cherubini, Stefania; Robinet, Jean-Christophe; De Palma, Pietro

    2016-12-01

    Subcritical transition in plane Poiseuille flow is investigated by means of a Lagrange-multiplier direct-adjoint optimization procedure with the aim of finding localized three-dimensional perturbations optimally growing in a given time interval (target time). Space localization of these optimal perturbations (OPs) is achieved by choosing as objective function either a p-norm (with p\\gg 1) of the perturbation energy density in a linear framework; or the classical (1-norm) perturbation energy, including nonlinear effects. This work aims at analyzing the structure of linear and nonlinear localized OPs for Poiseuille flow, and comparing their transition thresholds and scenarios. The nonlinear optimization approach provides three types of solutions: a weakly nonlinear, a hairpin-like and a highly nonlinear optimal perturbation, depending on the value of the initial energy and the target time. The former shows localization only in the wall-normal direction, whereas the latter appears much more localized and breaks the spanwise symmetry found at lower target times. Both solutions show spanwise inclined vortices and large values of the streamwise component of velocity already at the initial time. On the other hand, p-norm optimal perturbations, although being strongly localized in space, keep a shape similar to linear 1-norm optimal perturbations, showing streamwise-aligned vortices characterized by low values of the streamwise velocity component. When used for initializing direct numerical simulations, in most of the cases nonlinear OPs provide the most efficient route to transition in terms of time to transition and initial energy, even when they are less localized in space than the p-norm OP. The p-norm OP follows a transition path similar to the oblique transition scenario, with slightly oscillating streaks which saturate and eventually experience secondary instability. On the other hand, the nonlinear OP rapidly forms large-amplitude bent streaks and skips the phases

  12. Optimal network modification for spectral radius dependent phase transitions

    NASA Astrophysics Data System (ADS)

    Rosen, Yonatan; Kirsch, Lior; Louzoun, Yoram

    2016-09-01

    The dynamics of contact processes on networks is often determined by the spectral radius of the networks adjacency matrices. A decrease of the spectral radius can prevent the outbreak of an epidemic, or impact the synchronization among systems of coupled oscillators. The spectral radius is thus tightly linked to network dynamics and function. As such, finding the minimal change in network structure necessary to reach the intended spectral radius is important theoretically and practically. Given contemporary big data resources such as large scale communication or social networks, this problem should be solved with a low runtime complexity. We introduce a novel method for the minimal decrease in weights of edges required to reach a given spectral radius. The problem is formulated as a convex optimization problem, where a global optimum is guaranteed. The method can be easily adjusted to an efficient discrete removal of edges. We introduce a variant of the method which finds optimal decrease with a focus on weights of vertices. The proposed algorithm is exceptionally scalable, solving the problem for real networks of tens of millions of edges in a short time.

  13. Optimal precursor of the transition from Kuroshio large meander to straight path

    NASA Astrophysics Data System (ADS)

    Wang, Qiang; Ma, Libin; Xu, Qiangqiang

    2013-09-01

    We used the conditional nonlinear optimal perturbation (CNOP) method to explore the optimal precursor of the transition from Kuroshio large meander (LM) to straight path within a barotropic inflowout-flow model, and found that large amplitudes of the optimal precursor are mainly located in the east of Kyushu, which implies that perturbations in the region are important for the transition from LM to straight path. Furthermore, we investigated the transition processes caused by the optimal precursor, and found that these processes could be divided into three stages. In the first stage, a cyclonic eddy is advected to the formation region of the Kuroshio large meander, which enhances the LM path and causes a cyclonic eddy to shed from the Kuroshio mainstream. This process causes the LM path to change into a small meander path. Subsequently, the small meander is maintained for a period because the vorticity advection is balanced by the beta effect in the second stage. In the third stage, the small meander weakens and the straight path ultimately forms. The positive vorticity advecting downstream is responsible for this process. The exploration of the optimal precursor will conduce to improve the prediction of the transition processes from LM path to straight path, and its spatial structure can be used to guide Kuroshio targeted observation studies.

  14. Optimal Control of Markov Processes with Age-Dependent Transition Rates

    SciTech Connect

    Ghosh, Mrinal K. Saha, Subhamay

    2012-10-15

    We study optimal control of Markov processes with age-dependent transition rates. The control policy is chosen continuously over time based on the state of the process and its age. We study infinite horizon discounted cost and infinite horizon average cost problems. Our approach is via the construction of an equivalent semi-Markov decision process. We characterise the value function and optimal controls for both discounted and average cost cases.

  15. Phase transitions and optimal transport in stochastic roundabout traffic

    NASA Astrophysics Data System (ADS)

    Foulaadvand, M. Ebrahim; Maass, Philipp

    2016-07-01

    We study traffic in a roundabout model, where the dynamics along the interior lane of the roundabout are described by the totally asymmetric simple exclusion process (TASEP). Vehicles can enter the interior lane or exit from it via S intersecting streets with given rates, and locally modified dynamics at the junctions take into account that collisions of entering vehicles with vehicles approaching the entrance point from the interior lane should be avoided. A route matrix specifies the probabilities for vehicles to arrive from and to exit to certain intersecting streets. By subdividing the interior lane into segments between consecutive intersecting streets with effective entrance and exit rates, a classification of the stationary roundabout traffic in terms of TASEP multiphases is given, where each segment can be in either the low-density, high-density, or maximum current TASEP phase. A general methodology is developed, which allows one to calculate the multiphases and optimal throughput conditions based on a mean-field treatment. Explicit analytical results from this treatment are derived for equivalent interesting streets. The results are shown to be in good agreement with kinetic Monte Carlo simulations.

  16. Phase transitions and optimal transport in stochastic roundabout traffic.

    PubMed

    Foulaadvand, M Ebrahim; Maass, Philipp

    2016-07-01

    We study traffic in a roundabout model, where the dynamics along the interior lane of the roundabout are described by the totally asymmetric simple exclusion process (TASEP). Vehicles can enter the interior lane or exit from it via S intersecting streets with given rates, and locally modified dynamics at the junctions take into account that collisions of entering vehicles with vehicles approaching the entrance point from the interior lane should be avoided. A route matrix specifies the probabilities for vehicles to arrive from and to exit to certain intersecting streets. By subdividing the interior lane into segments between consecutive intersecting streets with effective entrance and exit rates, a classification of the stationary roundabout traffic in terms of TASEP multiphases is given, where each segment can be in either the low-density, high-density, or maximum current TASEP phase. A general methodology is developed, which allows one to calculate the multiphases and optimal throughput conditions based on a mean-field treatment. Explicit analytical results from this treatment are derived for equivalent interesting streets. The results are shown to be in good agreement with kinetic Monte Carlo simulations.

  17. Optimal nonlinear coherent mode transitions in Bose-Einstein condensates utilizing spatiotemporal controls

    NASA Astrophysics Data System (ADS)

    Hocker, David; Yan, Julia; Rabitz, Herschel

    2016-05-01

    Bose-Einstein condensates (BECs) offer the potential to examine quantum behavior at large length and time scales, as well as forming promising candidates for quantum technology applications. Thus, the manipulation of BECs using control fields is a topic of prime interest. We consider BECs in the mean-field model of the Gross-Pitaevskii equation (GPE), which contains linear and nonlinear features, both of which are subject to control. In this work we report successful optimal control simulations of a one-dimensional GPE by modulation of the linear and nonlinear terms to stimulate transitions into excited coherent modes. The linear and nonlinear controls are allowed to freely vary over space and time to seek their optimal forms. The determination of the excited coherent modes targeted for optimization is numerically performed through an adaptive imaginary time propagation method. Numerical simulations are performed for optimal control of mode-to-mode transitions between the ground coherent mode and the excited modes of a BEC trapped in a harmonic well. The results show greater than 99 % success for nearly all trials utilizing reasonable initial guesses for the controls, and analysis of the optimal controls reveals primarily direct transitions between initial and target modes. The success of using solely the nonlinearity term as a control opens up further research toward exploring novel control mechanisms inaccessible to linear Schrödinger-type systems.

  18. Optimization of transition edge sensor arrays for cosmic microwave background observations with the south pole telescope

    SciTech Connect

    Ding, Junjia; Ade, P. A. R.; Anderson, A. J.; Avva, J.; Ahmed, Z.; Arnold, K.; Austermann, J. E.; Bender, A. N.; Benson, B. A.; Bleem, L. E.; Byrum, K.; Carlstrom, J. E.; Carter, F. W.; Chang, C. L.; Cho, H. M.; Cliche, J. F.; Cukierman, A.; Czaplewski, D.; Divan, R.; de Haan, T.; Dobbs, M. A.; Dutcher, D.; Everett, W.; Gilbert, A.; Gannon, R.; Guyser, R.; Halverson, N. W.; Harrington, N. L.; Hattori, K.; Henning, J. W.; Hilton, G. C.; Holzapfel, W. L.; Hubmayr, J.; Huang, N.; Irwin, K. D.; Jeong, O.; Khaire, T.; Kubik, D.; Kuo, C. L.; Lee, A. T.; Leitch, E. M.; Meyer, S. S.; Miller, C. S.; Montgomery, J.; Nadolski, A.; Natoli, T.; Nguyen, H.; Novosad, V.; Padin, S.; Pan, Z.; Pearson, J.; Posada, C. M.; Rahlin, A.; Reichardt, C. L.; Ruhl, J. E.; Saliwanchik, B. R.; Sayre, J. T.; Shariff, J. A.; Shirley, I.; Shirokoff, E.; Smecher, G.; Sobrin, J.; Stan, L.; Stark, A. A.; Story, K.; Suzuki, A.; Tang, Q. Y.; Thakur, R. B.; Thompson, K. L.; Tucker, C.; Vanderlinde, K.; Vieira, J. D.; Wang, G.; Whitehorn, N.; Wu, W. L. K.; Yefremenko, V.; Yoon, K. W.

    2016-12-15

    In this study, we describe the optimization of transition-edge-sensor (TES) detector arrays for the thirdgeneration camera for the South PoleTelescope.The camera,which contains ~16 000 detectors, will make high-angular-resolution maps of the temperature and polarization of the cosmic microwave background. Our key results are scatter in the transition temperature of Ti/Au TESs is reduced by fabricating the TESs on a thin Ti(5 nm)/Au(5 nm) buffer layer and the thermal conductivity of the legs that support our detector islands is dominated by the SiOx dielectric in the microstrip transmission lines that run along

  19. Optimization of film synthesized rare earth transition metal permanent magnet systems

    SciTech Connect

    Cadieu, F.J.

    1990-01-01

    This report reviews work on the optimization of film synthesized rare earth transition metal permanent magnet systems. Topics include: high coercivity in Sm-Fe-Ti-V, Sm-Fe-V, and two element systems; ThMn{sub 12} type pseudobinary SmFe{sub 12 {minus} X}T{sub X}; and sputter process control for the synthesis of precisely textured RE-TM magnetic films. (JL)

  20. Anticipatory Control of Motion-to-Force Transitions With the Fingertips Adapts Optimally to Task Difficulty

    PubMed Central

    Cianchetti, Flor A.

    2010-01-01

    Moving our fingertips toward objects to produce well-directed forces immediately upon contact is fundamental to dexterous manipulation. This apparently simple motion-to-force transition in fact involves a time-critical, predictive switch in control strategy. Given that dexterous manipulation must accommodate multiple mechanical conditions, we investigated whether and how this transition adapts to task difficulty. Eight adults (19–39 yr) produced ramps of isometric vertical fingertip force against a rigid surface immediately following a tapping motion. By changing target surface friction and size, we defined an easier (sandpaper, 11 mm diam) versus a more difficult (polished steel, 5 mm diam) task. As in prior work, we assembled fine-wire electromyograms from all seven muscles of the index finger into a seven-dimensional vector defining the full muscle coordination pattern—and quantified its temporal evolution as its alignment with a reference coordination pattern vector for steady-state force production. As predicted by numerical optimizations to neuromuscular delays, our empirical and sigmoidal nonlinear regression analyses show that the coordination pattern transitions begin sooner for the more difficult tasks than for the easier tasks (∼120 ms, P < 0.02, and ∼115 ms, P < 0.015, respectively) and that the coordination pattern transition in alignment is well represented by a sigmoidal trend (R^2 > 0.7 in most cases). Importantly, the force vector following contact had smaller directional error (P < 0.02) for the more difficult task even though the transition in coordination pattern was less stereotypical and uniform than for the easier task. These adaptations of transition strategy to task difficulty are compatible with an optimization to counteract neuromuscular delays and noise to enable this fundamental element of dexterous manipulation. PMID:19889857

  1. Anticipatory control of motion-to-force transitions with the fingertips adapts optimally to task difficulty.

    PubMed

    Cianchetti, Flor A; Valero-Cuevas, Francisco J

    2010-01-01

    Moving our fingertips toward objects to produce well-directed forces immediately upon contact is fundamental to dexterous manipulation. This apparently simple motion-to-force transition in fact involves a time-critical, predictive switch in control strategy. Given that dexterous manipulation must accommodate multiple mechanical conditions, we investigated whether and how this transition adapts to task difficulty. Eight adults (19-39 yr) produced ramps of isometric vertical fingertip force against a rigid surface immediately following a tapping motion. By changing target surface friction and size, we defined an easier (sandpaper, 11 mm diam) versus a more difficult (polished steel, 5 mm diam) task. As in prior work, we assembled fine-wire electromyograms from all seven muscles of the index finger into a seven-dimensional vector defining the full muscle coordination pattern-and quantified its temporal evolution as its alignment with a reference coordination pattern vector for steady-state force production. As predicted by numerical optimizations to neuromuscular delays, our empirical and sigmoidal nonlinear regression analyses show that the coordination pattern transitions begin sooner for the more difficult tasks than for the easier tasks ( approximately 120 ms, P < 0.02, and approximately 115 ms, P < 0.015, respectively) and that the coordination pattern transition in alignment is well represented by a sigmoidal trend (R;2 > 0.7 in most cases). Importantly, the force vector following contact had smaller directional error (P < 0.02) for the more difficult task even though the transition in coordination pattern was less stereotypical and uniform than for the easier task. These adaptations of transition strategy to task difficulty are compatible with an optimization to counteract neuromuscular delays and noise to enable this fundamental element of dexterous manipulation.

  2. Some Results on the Analysis of Stochastic Processes with Uncertain Transition Probabilities and Robust Optimal Control

    SciTech Connect

    Keyong Li; Seong-Cheol Kang; I. Ch. Paschalidis

    2007-09-01

    This paper investigates stochastic processes that are modeled by a finite number of states but whose transition probabilities are uncertain and possibly time-varying. The treatment of uncertain transition probabilities is important because there appears to be a disconnection between the practice and theory of stochastic processes due to the difficulty of assigning exact probabilities to real-world events. Also, when the finite-state process comes as a reduced model of one that is more complicated in nature (possibly in a continuous state space), existing results do not facilitate rigorous analysis. Two approaches are introduced here. The first focuses on processes with one terminal state and the properties that affect their convergence rates. When a process is on a complicated graph, the bound of the convergence rate is not trivially related to that of the probabilities of individual transitions. Discovering the connection between the two led us to define two concepts which we call 'progressivity' and 'sortedness', and to a new comparison theorem for stochastic processes. An optimality criterion for robust optimal control also derives from this comparison theorem. In addition, this result is applied to the case of mission-oriented autonomous robot control to produce performance estimate within a control framework that we propose. The second approach is in the MDP frame work. We will introduce our preliminary work on optimistic robust optimization, which aims at finding solutions that guarantee the upper bounds of the accumulative discounted cost with prescribed probabilities. The motivation here is to address the issue that the standard robust optimal solution tends to be overly conservative.

  3. Utilizing Direct Numerical Simulations of Transition and Turbulence in Design Optimization

    NASA Technical Reports Server (NTRS)

    Rai, Man M.

    2015-01-01

    Design optimization methods that use the Reynolds-averaged Navier-Stokes equations with the associated turbulence and transition models, or other model-based forms of the governing equations, may result in aerodynamic designs with actual performance levels that are noticeably different from the expected values because of the complexity of modeling turbulence/transition accurately in certain flows. Flow phenomena such as wake-blade interaction and trailing edge vortex shedding in turbines and compressors (examples of such flows) may require a computational approach that is free of transition/turbulence models, such as direct numerical simulations (DNS), for the underlying physics to be computed accurately. Here we explore the possibility of utilizing DNS data in designing a turbine blade section. The ultimate objective is to substantially reduce differences between predicted performance metrics and those obtained in reality. The redesign of a typical low-pressure turbine blade section with the goal of reducing total pressure loss in the row is provided as an example. The basic ideas presented here are of course just as applicable elsewhere in aerodynamic shape optimization as long as the computational costs are not excessive.

  4. An optimization approach for analysing nonlinear stability with transition to turbulence in fluids as an exemplar.

    PubMed

    Kerswell, R R; Pringle, C C T; Willis, A P

    2014-08-01

    This article introduces and reviews recent work using a simple optimization technique for analysing the nonlinear stability of a state in a dynamical system. The technique can be used to identify the most efficient way to disturb a system such that it transits from one stable state to another. The key idea is introduced within the framework of a finite-dimensional set of ordinary differential equations (ODEs) and then illustrated for a very simple system of two ODEs which possesses bistability. Then the transition to turbulence problem in fluid mechanics is used to show how the technique can be formulated for a spatially-extended system described by a set of partial differential equations (the well-known Navier-Stokes equations). Within that context, the optimization technique bridges the gap between (linear) optimal perturbation theory and the (nonlinear) dynamical systems approach to fluid flows. The fact that the technique has now been recently shown to work in this very high dimensional setting augurs well for its utility in other physical systems.

  5. The ReSTAGE Collaboration: Defining Optimal Bleeding Criteria for Onset of Early Menopausal Transition

    PubMed Central

    Harlow, Siobán D.; Mitchell, Ellen S.; Crawford, Sybil; Nan, Bin; Little, Roderick; Taffe, John

    2008-01-01

    Study objective Criteria for staging the menopausal transition are not established. This paper evaluates five bleeding criteria for defining early transition and provides empirically-based guidance regarding optimal criteria. Design/Setting Prospective menstrual calendar data from four population-based cohorts: TREMIN, Melbourne Women’s Midlife Health Project(MWMHP), Seattle Midlife Women’s Health Study(SMWHS), and Study of Women’s Health Across the Nation(SWAN) with annual serum follicle stimulating hormone (FSH) from MWMHP and SWAN. Participants 735 TREMIN, 279 SMWHS, 216 MWMHP, and 2270 SWAN women aged 35-57 at baseline who maintained menstrual calendars. Main outcome measure(s) Age at and time to menopause for: standard deviation >6 and >8 days, persistent difference in consecutive segments >6 days, irregularity, and >=45 day segment. Serum follicle stimulating hormone concentration. Results Most women experienced each of the bleeding criteria. Except for persistent >6 day difference which occurs earlier, the criteria occur at a similar age and at approximately the same age as late transition in a large proportion of women. FSH was associated with all proposed markers. Conclusions The early transition may be best described by ovarian activity consistent with the persistent >6 day difference, but further study is needed, as other proposed criterion are consistent with later menstrual changes. PMID:17681300

  6. Theory of ultrafast nonresonant multiphoton transitions in polyatomic molecules: Basics and application to optimal control theory

    SciTech Connect

    May, Volkhard; Ambrosek, David; Oppel, Markus; Gonzalez, Leticia

    2007-10-14

    A systematic approach is presented to describe nonresonant multiphoton transitions, i.e., transitions between two electronic states without the presence of additional intermediate states resonant with the single-photon energy. The method is well suited to describe femtosecond spectroscopic experiments and, in particular, attempts to achieve laser pulse control of molecular dynamics. The obtained effective time-dependent Schroedinger equation includes effective couplings to the radiation field which combine powers of the field strength and effective transition dipole operators between the initial and final states. To arrive at time-local equations our derivation combines the well-known rotating wave approximation with the approximation of slowly varying amplitudes. Under these terms, the optimal control formalism can be readily extended to also account for nonresonant multiphoton events. Exemplary, nonresonant two- and three-photon processes, similar to those occurring in the recent femtosecond pulse-shaping experiments on CpMn(CO){sub 3}, are treated using related ab initio potential energy surfaces.

  7. Excited meson radiative transitions from lattice QCD using variationally optimized operators

    SciTech Connect

    Shultz, Christian J.; Dudek, Jozef J.; Edwards, Robert G.

    2015-06-02

    We explore the use of 'optimized' operators, designed to interpolate only a single meson eigenstate, in three-point correlation functions with a vector-current insertion. These operators are constructed as linear combinations in a large basis of meson interpolating fields using a variational analysis of matrices of two-point correlation functions. After performing such a determination at both zero and non-zero momentum, we compute three-point functions and are able to study radiative transition matrix elements featuring excited state mesons. The required two- and three-point correlation functions are efficiently computed using the distillation framework in which there is a factorization between quark propagation and operator construction, allowing for a large number of meson operators of definite momentum to be considered. We illustrate the method with a calculation using anisotopic lattices having three flavors of dynamical quark all tuned to the physical strange quark mass, considering form-factors and transitions of pseudoscalar and vector meson excitations. In conclusion, the dependence on photon virtuality for a number of form-factors and transitions is extracted and some discussion of excited-state phenomenology is presented.

  8. Explaining patterns in the school-to-work transition: An analysis using optimal matching.

    PubMed

    Dorsett, Richard; Lucchino, Paolo

    2014-12-01

    This paper studies the school to work transition in the UK with the aim of achieving a richer understanding of individuals' trajectories in the five years after reaching school leaving age. By applying the technique of 'optimal matching' on data from 1991 to 2008, we group individuals' trajectories post-16, and identify a small number of distinct transition patterns. Our results suggest that while 9 out of 10 young people have generally positive experiences post-16, the remaining individuals exhibit a variety of histories that might warrant policy attention. We assess the extent to which characteristics at age 16 can predict which type of trajectory a young person will follow. Our analysis shows that, despite the apparent heterogeneity, virtually all at-risk trajectories are associated with a relatively small set of key 'risk factors': early pregnancy; low educational attainment and self-confidence; and disadvantaged family background. These characteristics are known to be strongly correlated across individuals and raise concerns about the degree of socio-economic polarisation in the transition from school to work.

  9. Excited meson radiative transitions from lattice QCD using variationally optimized operators

    NASA Astrophysics Data System (ADS)

    Shultz, Christian J.; Dudek, Jozef J.; Edwards, Robert G.; Hadron Spectrum Collaboration

    2015-06-01

    We explore the use of "optimized" operators, designed to interpolate only a single meson eigenstate, in three-point correlation functions with a vector-current insertion. These operators are constructed as linear combinations in a large basis of meson interpolating fields using a variational analysis of matrices of two-point correlation functions. After performing such a determination at both zero and nonzero momentum, we compute three-point functions and are able to study radiative transition matrix elements featuring excited-state mesons. The required two- and three-point correlation functions are efficiently computed using the distillation framework in which there is a factorization between quark propagation and operator construction, allowing for a large number of meson operators of definite momentum to be considered. We illustrate the method with a calculation using anisotopic lattices having three flavors of dynamical quark all tuned to the physical strange quark mass, considering form factors and transitions of pseudoscalar and vector meson excitations. The dependence on photon virtuality for a number of form factors and transitions is extracted, and some discussion of excited-state phenomenology is presented.

  10. Limb darkening and exoplanets - II. Choosing the best law for optimal retrieval of transit parameters

    NASA Astrophysics Data System (ADS)

    Espinoza, Néstor; Jordán, Andrés

    2016-04-01

    Very precise measurements of exoplanet transit light curves both from ground- and space-based observatories make it now possible to fit the limb-darkening coefficients in the transit-fitting procedure rather than fix them to theoretical values. This strategy has been shown to give better results, as fixing the coefficients to theoretical values can give rise to important systematic errors which directly impact the physical properties of the system derived from such light curves such as the planetary radius. However, studies of the effect of limb-darkening assumptions on the retrieved parameters have mostly focused on the widely used quadratic limb-darkening law, leaving out other proposed laws that are either simpler or better descriptions of model intensity profiles. In this work, we show that laws such as the logarithmic, square-root and three-parameter law do a better job that the quadratic and linear laws when deriving parameters from transit light curves, both in terms of bias and precision, for a wide range of situations. We therefore recommend to study which law to use on a case-by-case basis. We provide code to guide the decision of when to use each of these laws and select the optimal one in a mean-square error sense, which we note has a dependence on both stellar and transit parameters. Finally, we demonstrate that the so-called exponential law is non-physical as it typically produces negative intensities close to the limb and should therefore not be used.

  11. Optimal and robust control and estimation of transition, convection, and turbulence

    NASA Astrophysics Data System (ADS)

    Bewley, Thomas Robinson

    The large increases in drag, cyclic structural loading, internal stresses, mixing, and heat transfer caused by turbulence in flows of engineering interest have motivated engineers to study turbulence and attempt to alter its effects. Recent advances in MEMS capabilities may soon make it possible to measure small-scale turbulent fluctuations of a flow and, subsequently, to apply coordinated small-scale forcing to the flow in order to achieve a desired large-scale effect. The present work attempts to develop techniques to derive the necessary control strategies for such control problems from first principles, leveraging our knowledge of the Navier-Stokes equation which governs these flows and our ability to simulate this equation accurately in simple configurations. By so doing, we bypass the ad hoc assumptions about the turbulence dynamics often used to determine such control strategies and develop several new tools for analysis of flow systems in the control setting. Approaching this difficult problem in steps of gradually increasing complexity, optimal and robust control theories are used in the present work to derive and demonstrate effective control and estimation strategies for three important model problems in fluid mechanics. The model problems considered are: (1)the application of linear optimal/robust control theory to the linear paths to transition in a plane channel, (2)the application of linear optimal/robust control theory to a low-order nonlinear chaotic convection problem, and (3)the application of optimal control theory in a DNS-based predictive control setting to the fully nonlinear problem of turbulence. In order to develop feedback algorithms for practical (disturbed) environments, it is recognized that a degree of robustness will be necessary in the control rules. In the final section of this work, a general framework for robust control for problems governed by the Navier-Stokes equation is established by mathematical analysis, laying the

  12. An Information-theoretic Approach to Optimize JWST Observations and Retrievals of Transiting Exoplanet Atmospheres

    NASA Astrophysics Data System (ADS)

    Howe, Alex R.; Burrows, Adam; Deming, Drake

    2017-01-01

    We provide an example of an analysis to explore the optimization of observations of transiting hot Jupiters with the James Webb Space Telescope (JWST) to characterize their atmospheres based on a simple three-parameter forward model. We construct expansive forward model sets for 11 hot Jupiters, 10 of which are relatively well characterized, exploring a range of parameters such as equilibrium temperature and metallicity, as well as considering host stars over a wide range in brightness. We compute posterior distributions of our model parameters for each planet with all of the available JWST spectroscopic modes and several programs of combined observations and compute their effectiveness using the metric of estimated mutual information per degree of freedom. From these simulations, clear trends emerge that provide guidelines for designing a JWST observing program. We demonstrate that these guidelines apply over a wide range of planet parameters and target brightnesses for our simple forward model.

  13. Optimizing Transition Edge Sensors for High-Resolution X-ray Spectroscopy

    SciTech Connect

    Saab, Tarek; Bandler, Simon R.; Boyce, Kevin; Chervenak, James A.; Figueroa-Feliciano, Enectali; Iyomoto, Naoko; Kelley, Richard L.; Kilbourne, Caroline A.; Porter, Frederick S.; Sadleir, John E

    2006-09-07

    Transition Edge Sensors (TES) have found applications as astronomical detectors ranging from the microwave to the gamma ray energy bands. Each energy band, however, imposes a different set of requirements on the TES such as energy and timing resolution, focal plane coverage, and the mechanisms by which the signal is coupled to the detector. This paper focuses on the development of TESs optimized for the 0.1-10 keV energy range at the NASA Goddard Space Flight Center. Such detectors are suitable candidates for some of the upcoming X-ray observatories such as NeXT and Constellation-X. Ongoing efforts at producing, characterizing, and modeling such devices, as well as the latest results, are discussed.

  14. Quantum Efficiency Characterization and Optimization of a Tungsten Transition-Edge Sensor for ALPS II

    NASA Astrophysics Data System (ADS)

    Bastidon, Noëmie; Horns, Dieter; Lindner, Axel

    2016-07-01

    The ALPS II experiment, Any Light Particle Search II at DESY in Hamburg, will look for sub-eV mass new fundamental bosons (e.g., axion-like particles, hidden photons, and other weakly interacting sub-eV particles) in the next years by means of a light-shining-through-wall setup. The ALPS II photosensor is a tungsten transition-edge sensor (W-TES) optimized for 1064 nm photons. This TES, operated at 80 mK, has already allowed single infrared photon detections as well as non-dispersive spectroscopy with very low background rates. The demonstrated quantum efficiency for such TES is up to 95 % (1064 nm) as has been already demonstrated by the US National Institute of Standards and Technology. A back-to-back measurement of the ALPS TES quantum efficiency using a calibrated charge-coupled device camera has lead to a first estimation of 30 %. Improvement methods are discussed.

  15. Nonlinear optimal control of bypass transition in a boundary layer flow

    NASA Astrophysics Data System (ADS)

    Xiao, Dandan; Papadakis, George

    2016-11-01

    Bypass transition is observed in a flat-plate boundary-layer flow when high levels of free stream turbulence are present. This scenario is characterized by the formation of streamwise elongated streaks inside the boundary layer, their break down into turbulent spots and eventually fully turbulent flow. In the current work, we perform DNS simulations of control of bypass transition in a zero-pressure-gradient boundary layer. A non-linear optimal control algorithm is developed that employs the direct-adjoint approach to minimise a quadratic cost function based on the deviation from the Blasius velocity profile. Using the Lagrange variational approach, the distribution of the blowing/suction control velocity is found by solving iteratively the non-linear Navier-Stokes and its adjoint equations in a forward/backward loop. The optimisation is performed over a finite time horizon during which the Lagrange functional is to be minimised. Large values of optimisation horizon result in instability of the adjoint equations. The results show that the controller is able to reduce the turbulent kinetic energy of the flow in the region where the objective function is defined and the velocity profile is seen to approach the Blasius solution. Significant drag reduction is also achieved.

  16. An optimized transit peptide for effective targeting of diverse foreign proteins into chloroplasts in rice

    PubMed Central

    Shen, Bo-Ran; Zhu, Cheng-Hua; Yao, Zhen; Cui, Li-Li; Zhang, Jian-Jun; Yang, Cheng-Wei; He, Zheng-Hui; Peng, Xin-Xiang

    2017-01-01

    Various chloroplast transit peptides (CTP) have been used to successfully target some foreign proteins into chloroplasts, but for other proteins these same CTPs have reduced localization efficiencies or fail completely. The underlying cause of the failures remains an open question, and more effective CTPs are needed. In this study, we initially observed that two E.coli enzymes, EcTSR and EcGCL, failed to be targeted into rice chloroplasts by the commonly-used rice rbcS transit peptide (rCTP) and were subsequently degraded. Further analyses revealed that the N-terminal unfolded region of cargo proteins is critical for their localization capability, and that a length of about 20 amino acids is required to attain the maximum localization efficiency. We considered that the unfolded region may alleviate the steric hindrance produced by the cargo protein, by functioning as a spacer to which cytosolic translocators can bind. Based on this inference, an optimized CTP, named RC2, was constructed. Analyses showed that RC2 can more effectively target diverse proteins, including EcTSR and EcGCL, into rice chloroplasts. Collectively, our results provide further insight into the mechanism of CTP-mediated chloroplastic localization, and more importantly, RC2 can be widely applied in future chloroplastic metabolic engineering, particularly for crop plants.

  17. Transition.

    ERIC Educational Resources Information Center

    Thompson, Sandy, Ed.; And Others

    1990-01-01

    This "feature issue" focuses on transition from school to adult life for persons with disabilities. Included are "success stories," brief program descriptions, and a list of resources. Individual articles include the following titles and authors: "Transition: An Energizing Concept" (Paul Bates); "Transition…

  18. Combinatorial optimization using dynamical phase transitions in driven-dissipative systems

    NASA Astrophysics Data System (ADS)

    Leleu, Timothée; Yamamoto, Yoshihisa; Utsunomiya, Shoko; Aihara, Kazuyuki

    2017-02-01

    The dynamics of driven-dissipative systems is shown to be well-fitted for achieving efficient combinatorial optimization. The proposed method can be applied to solve any combinatorial optimization problem that is equivalent to minimizing an Ising Hamiltonian. Moreover, the dynamics considered can be implemented using various physical systems as it is based on generic dynamics—the normal form of the supercritical pitchfork bifurcation. The computational principle of the proposed method relies on an hybrid analog-digital representation of the binary Ising spins by considering the gradient descent of a Lyapunov function that is the sum of an analog Ising Hamiltonian and archetypal single or double-well potentials. By gradually changing the shape of the latter potentials from a single to double well shape, it can be shown that the first nonzero steady states to become stable are associated with global minima of the Ising Hamiltonian, under the approximation that all analog spins have the same amplitude. In the more general case, the heterogeneity in amplitude between analog spins induces the stabilization of local minima, which reduces the quality of solutions to combinatorial optimization problems. However, we show that the heterogeneity in amplitude can be reduced by setting the parameters of the driving signal near a regime, called the dynamic phase transition, where the analog spins' DC components map more accurately the global minima of the Ising Hamiltonian which, in turn, increases the quality of solutions found. Last, we discuss the possibility of a physical implementation of the proposed method using networks of degenerate optical parametric oscillators.

  19. Anthropogenic carbon estimates in the Weddell Sea using an optimized CFC based transit time distribution approach

    NASA Astrophysics Data System (ADS)

    Huhn, Oliver; Hauck, Judith; Hoppema, Mario; Rhein, Monika; Roether, Wolfgang

    2010-05-01

    We use a 20 year time series of chlorofluorocarbon (CFC) observations along the Prime Meridian to determine the temporal evolution of anthropogenic carbon (Cant) in the two deep boundary currents which enter the Weddell Basin in the south and leave it in the north. The Cant is inferred from transit time distributions (TTDs), with parameters (mean transit time and dispersion) adjusted to the observed mean CFC histories in these recently ventilated deep boundary currents. We optimize that "classic" TTD approach by accounting for water exchange of the boundary currents with an old but not CFC and Cant free interior reservoir. This reservoir in turn, is replenished by the boundary currents, which we parameterize as first order mixing. Furthermore, we account for the time-dependence of the CFC and Cant source water saturation. A conceptual model of an ideal saturated mixed layer and exchange with adjacent water is adjusted to observed CFC saturations in the source regions. The time-dependence for the CFC saturation appears to be much weaker than for Cant. We find a mean transit time of 14 years and an advection/dispersion ratio of 5 for the deep southern boundary current. For the northern boundary current we find a mean transit time of 8 years and a much advection/dispersion ratio of 140. The fractions directly supplied by the boundary currents are in both cases in the order of 10%, while 90% are admixed from the interior reservoirs, which are replenished with a renewal time of about 14 years. We determine Cant ~ 11 umol/kg (reference year 2006) in the deep water entering the Weddell Sea in the south (~2.1 Sv), and 12 umol/kg for the deep water leaving the Weddell Sea in the north (~2.7 Sv). These Cant estimates are, however, upper limits, considering that the Cant source water saturation is likely to be lower than that for the CFCs. Comparison with Cant intrusion estimates based on extended multiple linear regression (using potential temperature, salinity, oxygen, and

  20. Optimization of group delay response of (apodized) tapered fiber Bragg grating by shaping taper transition and apodization window

    NASA Astrophysics Data System (ADS)

    Markowski, Konrad; Jedrzejewski, Kazimierz; Osuch, Tomasz

    2016-09-01

    This article presents implementation of the Simulated Annealing (SA) algorithm for tapered fiber Bragg gratings (TFBGs) design. Particularly, together with well-known Coupled Mode Theory (CMT) and Transfer Matrix Method (TMM) the algorithm optimizes the group delay response of TFBG, by simultaneous shaping of both apodization function and tapered fiber transition profile. Prior to the optimization process, numerical model for TFBG design has been validated. Preliminary results reveal great potential of the SA-based approach and with proper definition of the design criteria may be even applied for optimization of the spectral properties of TFBGs.

  1. Managing the Transition: The Role of Optimism and Self-Efficacy for First-Year Australian University Students

    ERIC Educational Resources Information Center

    Morton, Stephen; Mergler, Amanda; Boman, Peter

    2014-01-01

    Students making the transition from high school to university often encounter many stressors and new experiences. Many students adjust successfully to university; however, some students do not, often resulting in attrition from the university and mental health issues. The primary aim of the current study was to examine the effects that optimism,…

  2. Study of the bus dynamic coscheduling optimization method under urban rail transit line emergency.

    PubMed

    Wang, Yun; Yan, Xuedong; Zhou, Yu; Wang, Jiaxi; Chen, Shasha

    2014-01-01

    As one of the most important urban commuter transportation modes, urban rail transit (URT) has been acting as a key solution for supporting mobility needs in high-density urban areas. However, in recent years, high frequency of unexpected events has caused serious service disruptions in URT system, greatly harming passenger safety and resulting in severe traffic delays. Therefore, there is an urgent need to study emergency evacuation problem in URT. In this paper, a method of bus dynamic coscheduling is proposed and two models are built based on different evacuation destinations including URT stations and surrounding bus parking spots. A dynamic coscheduling scheme for buses can be obtained by the models. In the model solution process, a new concept-the equivalent parking spot-is proposed to transform the nonlinear model into an integer linear programming (ILP) problem. A case study is conducted to verify the feasibility of models. Also, sensitivity analysis of two vital factors is carried out to analyze their effects on the total evacuation time. The results reveal that the designed capacity of buses has a negative influence on the total evacuation time, while an increase in the number of passengers has a positive effect. Finally, some significant optimizing strategies are proposed.

  3. Study of the Bus Dynamic Coscheduling Optimization Method under Urban Rail Transit Line Emergency

    PubMed Central

    Yan, Xuedong; Wang, Jiaxi; Chen, Shasha

    2014-01-01

    As one of the most important urban commuter transportation modes, urban rail transit (URT) has been acting as a key solution for supporting mobility needs in high-density urban areas. However, in recent years, high frequency of unexpected events has caused serious service disruptions in URT system, greatly harming passenger safety and resulting in severe traffic delays. Therefore, there is an urgent need to study emergency evacuation problem in URT. In this paper, a method of bus dynamic coscheduling is proposed and two models are built based on different evacuation destinations including URT stations and surrounding bus parking spots. A dynamic coscheduling scheme for buses can be obtained by the models. In the model solution process, a new concept—the equivalent parking spot—is proposed to transform the nonlinear model into an integer linear programming (ILP) problem. A case study is conducted to verify the feasibility of models. Also, sensitivity analysis of two vital factors is carried out to analyze their effects on the total evacuation time. The results reveal that the designed capacity of buses has a negative influence on the total evacuation time, while an increase in the number of passengers has a positive effect. Finally, some significant optimizing strategies are proposed. PMID:25530750

  4. Optimizing Transition-Edge Sensor Design for High Count-Rate Applications

    SciTech Connect

    Smith, Stephen J.; Adams, Joe S.; Bandler, Simon R.; Brekosky, Regis P.; Brown, Ari-D.; Chervenak, James A.; Eckart, Megan E.; Kelley, Richard L.; Kilbourne, Caroline A.; Scott Porter, F.; Finkbeiner, Fred M.; Sadleir, John E.

    2009-12-16

    We are developing transition-edge sensor (TES) X-ray detectors optimized for high count-rate applications. These devices are fabricated on thick (300 {mu}m) Si substrates, resulting in a 20 times increase in thermal conductance to the heat sink compared to our conventional membrane isolated TES's. Operating a TES with higher heat sink conductance requires 4.5 times more bias current. This results in a 2.7 times increase in {beta}, the logarithmic derivative of resistance with respect to current. Noise measurements show a lower limit on the TES excess noise scales as (2{beta}){sup 1/2}, consistent with the near-equilibrium, non-linear expansion of the Ohmic Johnson noise. This is consistent with our membrane devices though the increased {beta} means the theoretical best attainable resolution is degraded by 25-35%. We have tested devices with different contact geometries between the absorber, and the TES and substrate. This allows us to investigate the loss of athermal phonons to the substrate, which can degrade the resolution. Results show a correlation between the stem contact area and a low-energy tail in the spectral response at 5.9 keV due to the athermal phonon loss. In several devices tested we demonstrate a resolution of 4.1-5.6 eV, coupled with detector time constants as fast as 44 {mu}s, representing an increase in detector response by 7 times compared to the membrane devices.

  5. Streamlining the Design-to-Build Transition with Build-Optimization Software Tools.

    PubMed

    Oberortner, Ernst; Cheng, Jan-Fang; Hillson, Nathan J; Deutsch, Samuel

    2017-03-17

    Scaling-up capabilities for the design, build, and test of synthetic biology constructs holds great promise for the development of new applications in fuels, chemical production, or cellular-behavior engineering. Construct design is an essential component in this process; however, not every designed DNA sequence can be readily manufactured, even using state-of-the-art DNA synthesis methods. Current biological computer-aided design and manufacture tools (bioCAD/CAM) do not adequately consider the limitations of DNA synthesis technologies when generating their outputs. Designed sequences that violate DNA synthesis constraints may require substantial sequence redesign or lead to price-premiums and temporal delays, which adversely impact the efficiency of the DNA manufacturing process. We have developed a suite of build-optimization software tools (BOOST) to streamline the design-build transition in synthetic biology engineering workflows. BOOST incorporates knowledge of DNA synthesis success determinants into the design process to output ready-to-build sequences, preempting the need for sequence redesign. The BOOST web application is available at https://boost.jgi.doe.gov and its Application Program Interfaces (API) enable integration into automated, customized DNA design processes. The herein presented results highlight the effectiveness of BOOST in reducing DNA synthesis costs and timelines.

  6. Near-optimal energy transitions for energy-state trajectories of hypersonic aircraft

    NASA Technical Reports Server (NTRS)

    Ardema, M. D.; Bowles, J. V.; Terjesen, E. J.; Whittaker, T.

    1992-01-01

    A problem of the instantaneous energy transition that occurs in energy-state approximation is considered. The transitions are modeled as a sequence of two load-factor bounded paths (either climb-dive or dive-climb). The boundary-layer equations associated with the energy-state dynamic model are analyzed to determine the precise location of the transition.

  7. Optimization of film synthesized rare earth transition metal permanent magnet systems. Progress report, August 1, 1989--July 1990

    SciTech Connect

    Cadieu, F.J.

    1990-12-31

    This report reviews work on the optimization of film synthesized rare earth transition metal permanent magnet systems. Topics include: high coercivity in Sm-Fe-Ti-V, Sm-Fe-V, and two element systems; ThMn{sub 12} type pseudobinary SmFe{sub 12 {minus} X}T{sub X}; and sputter process control for the synthesis of precisely textured RE-TM magnetic films. (JL)

  8. Role of Physical Therapists in Reducing Hospital Readmissions: Optimizing Outcomes for Older Adults During Care Transitions From Hospital to Community

    PubMed Central

    Burke, Robert E.; Malone, Daniel; Ridgeway, Kyle J.; McManus, Beth M.; Stevens-Lapsley, Jennifer E.

    2016-01-01

    Hospital readmissions in older adult populations are an emerging quality indicator for acute care hospitals. Recent evidence has linked functional decline during and after hospitalization with an elevated risk of hospital readmission. However, models of care that have been developed to reduce hospital readmission rates do not adequately address functional deficits. Physical therapists, as experts in optimizing physical function, have a strong opportunity to contribute meaningfully to care transition models and demonstrate the value of physical therapy interventions in reducing readmissions. Thus, the purposes of this perspective article are: (1) to describe the need for physical therapist input during care transitions for older adults and (2) to outline strategies for expanding physical therapy participation in care transitions for older adults, with an overall goal of reducing avoidable 30-day hospital readmissions. PMID:26939601

  9. Increasing the sampling efficiency of protein conformational transition using velocity-scaling optimized hybrid explicit/implicit solvent REMD simulation

    SciTech Connect

    Yu, Yuqi; Wang, Jinan; Shao, Qiang E-mail: Jiye.Shi@ucb.com Zhu, Weiliang E-mail: Jiye.Shi@ucb.com; Shi, Jiye E-mail: Jiye.Shi@ucb.com

    2015-03-28

    The application of temperature replica exchange molecular dynamics (REMD) simulation on protein motion is limited by its huge requirement of computational resource, particularly when explicit solvent model is implemented. In the previous study, we developed a velocity-scaling optimized hybrid explicit/implicit solvent REMD method with the hope to reduce the temperature (replica) number on the premise of maintaining high sampling efficiency. In this study, we utilized this method to characterize and energetically identify the conformational transition pathway of a protein model, the N-terminal domain of calmodulin. In comparison to the standard explicit solvent REMD simulation, the hybrid REMD is much less computationally expensive but, meanwhile, gives accurate evaluation of the structural and thermodynamic properties of the conformational transition which are in well agreement with the standard REMD simulation. Therefore, the hybrid REMD could highly increase the computational efficiency and thus expand the application of REMD simulation to larger-size protein systems.

  10. Structural and magnetic phase transitions near optimal superconductivity in BaFe2(As1-xPx)2

    DOE PAGES

    Hu, Ding; Lu, Xingye; Zhang, Wenliang; ...

    2015-04-17

    In this study, we use nuclear magnetic resonance (NMR), high-resolution x-ray and neutron scattering to study structural and magnetic phase transitions in phosphorus-doped BaFe2(As1-xPx)2. Thus, previous transport, NMR, specific heat, and magnetic penetration depth measurements have provided compelling evidence for the presence of a quantum critical point (QCP) near optimal superconductivity at x = 0.3. However, we show that the tetragonal-to-orthorhombic structural (Ts) and paramagnetic to antiferromagnetic (AF, TN) transitions in BaFe2(As1-xPx)2 are always coupled and approach to TN ≈ Ts ≥ Tc (≈ 29 K) for x = 0.29 before vanishing abruptly for x ≥ 0.3. These results suggestmore » that AF order in BaFe2(As1-xPx)2 disappears in a weakly first order fashion near optimal superconductivity, much like the electron-doped iron pnictides with an avoided QCP.« less

  11. Extending single-photon optimized superconducting transition edge sensors beyond the single-photon counting regime.

    PubMed

    Gerrits, Thomas; Calkins, Brice; Tomlin, Nathan; Lita, Adriana E; Migdall, Alan; Mirin, Richard; Nam, Sae Woo

    2012-10-08

    Typically, transition edge sensors resolve photon number of up to 10 or 20 photons, depending on the wavelength and TES design. We extend that dynamic range up to 1000 photons, while maintaining sub-shot noise detection process uncertainty of the number of detected photons and beyond that show a monotonic response up to ≈ 6 · 10(6) photons in a single light pulse. This mode of operation, which heats the sensor far beyond its transition edge into the normal conductive regime, offers a technique for connecting single-photon-counting measurements to radiant-power measurements at picowatt levels. Connecting these two usually incompatible operating regimes in a single detector offers significant potential for directly tying photon counting measurements to conventional cryogenic radiometric standards. In addition, our measurements highlight the advantages of a photon-number state source over a coherent pulse source as a tool for characterizing such a detector.

  12. Optimization of film synthesized rare earth transition metal permanent magnet systems

    SciTech Connect

    Cadieu, F.J.

    1992-01-01

    Progress is reported in three areas: high coercivity Sm-Fe-Ti-V, Sm-Fe-Zr, and two element Sm-Fe Sm{sub 5}(Fe,T){sub 17} type crystalline phases; ThMn{sub 12} type pseudobinary SmFe{sub 12-x}T{sub x}(0{le}{times}{le}1.5); and sputter process control for the synthesis of precisely textured rare earth-transition metal magnetic films. (DLC)

  13. Phase transitions in optimal search times: How random walkers should combine resetting and flight scales.

    PubMed

    Campos, Daniel; Méndez, Vicenç

    2015-12-01

    Recent works have explored the properties of Lévy flights with resetting in one-dimensional domains and have reported the existence of phase transitions in the phase space of parameters which minimizes the mean first passage time (MFPT) through the origin [L. Kusmierz et al., Phys. Rev. Lett. 113, 220602 (2014)]. Here, we show how actually an interesting dynamics, including also phase transitions for the minimization of the MFPT, can also be obtained without invoking the use of Lévy statistics but for the simpler case of random walks with exponentially distributed flights of constant speed. We explore this dynamics both in the case of finite and infinite domains, and for different implementations of the resetting mechanism to show that different ways to introduce resetting consistently lead to a quite similar dynamics. The use of exponential flights has the strong advantage that exact solutions can be obtained easily for the MFPT through the origin, so a complete analytical characterization of the system dynamics can be provided. Furthermore, we discuss in detail how the phase transitions observed in random walks with resetting are closely related to several ideas recurrently used in the field of random search theory, in particular, to other mechanisms proposed to understand random search in space as mortal random walks or multiscale random walks. As a whole, we corroborate that one of the essential ingredients behind MFPT minimization lies in the combination of multiple movement scales (regardless of their specific origin).

  14. New Constraints on ΩM, ΩΛ, and w from an Independent Set of 11 High-Redshift Supernovae Observed with the Hubble Space Telescope

    NASA Astrophysics Data System (ADS)

    Knop, R. A.; Aldering, G.; Amanullah, R.; Astier, P.; Blanc, G.; Burns, M. S.; Conley, A.; Deustua, S. E.; Doi, M.; Ellis, R.; Fabbro, S.; Folatelli, G.; Fruchter, A. S.; Garavini, G.; Garmond, S.; Garton, K.; Gibbons, R.; Goldhaber, G.; Goobar, A.; Groom, D. E.; Hardin, D.; Hook, I.; Howell, D. A.; Kim, A. G.; Lee, B. C.; Lidman, C.; Mendez, J.; Nobili, S.; Nugent, P. E.; Pain, R.; Panagia, N.; Pennypacker, C. R.; Perlmutter, S.; Quimby, R.; Raux, J.; Regnault, N.; Ruiz-Lapuente, P.; Sainton, G.; Schaefer, B.; Schahmaneche, K.; Smith, E.; Spadafora, A. L.; Stanishev, V.; Sullivan, M.; Walton, N. A.; Wang, L.; Wood-Vasey, W. M.; Yasuda, N.

    2003-11-01

    We report measurements of ΩM, ΩΛ, and w from 11 supernovae (SNe) at z=0.36-0.86 with high-quality light curves measured using WFPC2 on the Hubble Space Telescope (HST). This is an independent set of high-redshift SNe that confirms previous SN evidence for an accelerating universe. The high-quality light curves available from photometry on WFPC2 make it possible for these 11 SNe alone to provide measurements of the cosmological parameters comparable in statistical weight to the previous results. Combined with earlier Supernova Cosmology Project data, the new SNe yield a measurement of the mass density ΩM=0.25+0.07-0.06(statistical)+/-0.04 (identified systematics), or equivalently, a cosmological constant of ΩΛ=0.75+0.06-0.07(statistical)+/-0.04 (identified systematics), under the assumptions of a flat universe and that the dark energy equation-of-state parameter has a constant value w=-1. When the SN results are combined with independent flat-universe measurements of ΩM from cosmic microwave background and galaxy redshift distortion data, they provide a measurement of w=-1.05+0.15-0.20(statistical)+/-0.09 (identified systematic), if w is assumed to be constant in time. In addition to high-precision light-curve measurements, the new data offer greatly improved color measurements of the high-redshift SNe and hence improved host galaxy extinction estimates. These extinction measurements show no anomalous negative E(B-V) at high redshift. The precision of the measurements is such that it is possible to perform a host galaxy extinction correction directly for individual SNe without any assumptions or priors on the parent E(B-V) distribution. Our cosmological fits using full extinction corrections confirm that dark energy is required with P(ΩΛ>0)>0.99, a result consistent with previous and current SN analyses that rely on the identification of a low-extinction subset or prior assumptions concerning the intrinsic extinction distribution. Based in part on

  15. Propulsion system-flight control integration and optimization: Flight evaluation and technology transition

    NASA Technical Reports Server (NTRS)

    Burcham, Frank W., Jr.; Gilyard, Glenn B.; Myers, Lawrence P.

    1990-01-01

    Integration of propulsion and flight control systems and their optimization offers significant performance improvements. Research programs were conducted which have developed new propulsion and flight control integration concepts, implemented designs on high-performance airplanes, demonstrated these designs in flight, and measured the performance improvements. These programs, first on the YF-12 airplane, and later on the F-15, demonstrated increased thrust, reduced fuel consumption, increased engine life, and improved airplane performance; with improvements in the 5 to 10 percent range achieved with integration and with no changes to hardware. The design, software and hardware developments, and testing requirements were shown to be practical.

  16. Optimizing the superconducting transition temperature and upper critical field of Sn1-xInxTe

    NASA Astrophysics Data System (ADS)

    Zhong, R. D.; Schneeloch, J. A.; Shi, X. Y.; Xu, Z. J.; Zhang, C.; Tranquada, J. M.; Li, Q.; Gu, G. D.

    2013-07-01

    Sn1-xInxTe is a possible candidate for topological superconductivity. Previous work has shown that substitution of In for Sn in the topological crystalline insulator SnTe results in superconductivity, with the transition temperature, Tc, growing with In concentration. We have performed a systematic investigation of Sn1-xInxTe for a broad range of x, synthesizing single crystals (by a modified floating-zone method) as well as polycrystalline samples. The samples have been characterized by x-ray diffraction, resistivity, and magnetization. For the single crystals, the maximum Tc is obtained at x=0.45 with a value of 4.5 K, as determined by the onset of diamagnetism.

  17. A self-contained, automated methodology for optimal flow control validated for transition delay

    NASA Technical Reports Server (NTRS)

    Joslin, Ronald D.; Gunzburger, Max D.; Nicolaides, R. A.; Erlebacher, Gordon; Hussaini, M. Yousuff

    1995-01-01

    This paper describes a self-contained, automated methodology for flow control along with a validation of the methodology for the problem of boundary layer instability suppression. The objective of control is to match the stress vector along a portion of the boundary to a given vector; instability suppression is achieved by choosing the given vector to be that of a steady base flow, e.g., Blasius boundary layer. Control is effected through the injection or suction of fluid through a single orifice on the boundary. The present approach couples the time-dependent Navier-Stokes system with an adjoint Navier-Stokes system and optimality conditions from which optimal states, i.e., unsteady flow fields, and control, e.g., actuators, may be determined. The results demonstrate that instability suppression can be achieved without any a priori knowledge of the disturbance, which is significant because other control techniques have required some knowledge of the flow unsteadiness such as frequencies, instability type, etc.

  18. Vortex phase transition and anisotropy behavior of optimized (Li1-x Fe x OH)FeSe single crystals

    NASA Astrophysics Data System (ADS)

    Yi, Xiaolei; Wang, Chunlei; Tang, Qingbin; Peng, Tao; Qiu, Yang; Xu, Junqi; Sun, Haibin; Luo, Yongsong; Yu, Benhai

    2016-10-01

    (Li1-x Fe x OH)FeSe single crystals have been successfully synthesized by a hydrothermal ion-exchange technique. We have carried out systematic research on the influence of the concentration of selenourea (c m) on the superconducting properties of (Li1-x Fe x OH)FeSe single crystals. The optimized specimens possess an onset superconducting transition temperature T c of up to 42 K obtained at c m = 0.8 mol l-1, and the corresponding residual resistivity ratio (RRR = ρ (300 K)/ρ (T c)) is estimated to be 11. The vortex liquid-to-glass phase transition has been discussed based on the collective pinning model. The large distance between the H g and H c2 lines, as well as the much narrower region of the pinned vortex-liquid phase, indicate a weak vortex-pinning ability in (Li1-x Fe x OH)FeSe single crystals. The big out-plane anisotropy behavior versus temperature has been explored according to the anisotropic Ginzburg-Landau theory, and the anisotropy factor Γ displays linear behavior towards temperature similar to that of SmFeAsO1-x F x superconductors.

  19. Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana

    PubMed Central

    Gawroński, Piotr; Górecka, Magdalena; Bederska, Magdalena; Rusaczonek, Anna; Ślesak, Ireneusz; Kruk, Jerzy; Karpiński, Stanisław

    2013-01-01

    Isochorismate synthase 1 (ICS1) is a crucial enzyme in the salicylic acid (SA) synthesis pathway, and thus it is important for immune defences. The ics1 mutant is used in experiments on plant–pathogen interactions, and ICS1 is required for the appropriate hypersensitive disease defence response. However, ICS1 also takes part in the synthesis of phylloquinone, which is incorporated into photosystem I and is an important component of photosynthetic electron transport in plants. Therefore, photosynthetic and molecular analysis of the ics1 mutant in comparison with wild-type and SA-degrading transgenic NahG Arabidopsis thaliana plants was performed. Photosynthetic parameters in the ics1 mutant, when compared with the wild type, were changed in a manner observed previously for state transition-impaired plants (STN7 kinase recessive mutant, stn7). In contrast to stn7, deregulation of the redox status of the plastoquinone pool (measured as 1–q p) in ics1 showed significant variation depending on the leaf age. SA-degrading transgenic NahG plants targeted to the cytoplasm or chloroplasts displayed normal (wild-type-like) state transition. However, ics1 plants treated with a phylloquinone precursor displayed symptoms of phenotypic reversion towards the wild type. ics1 also showed altered thylakoid structure with an increased number of stacked thylakoids per granum which indicates the role of ICS1 in regulation of state transition. The results presented here suggest the role of ICS1 in integration of the chloroplast ultrastructure, the redox status of the plastoquinone pool, and organization of the photosystems, which all are important for optimal immune defence and light acclimatory responses. PMID:23956412

  20. Optimization of crystal nucleation close to a metastable fluid-fluid phase transition.

    PubMed

    Wedekind, Jan; Xu, Limei; Buldyrev, Sergey V; Stanley, H Eugene; Reguera, David; Franzese, Giancarlo

    2015-06-22

    The presence of a metastable fluid-fluid critical point is thought to dramatically influence the crystallization pathway, increasing the nucleation rate by many orders of magnitude over the predictions of classical nucleation theory. We use molecular dynamics simulations to study the kinetics of crystallization in the vicinity of this metastable critical point and throughout the metastable fluid-fluid phase diagram. To quantitatively understand how the fluid-fluid phase separation affects the crystal nucleation, we evaluate accurately the kinetics and reconstruct the thermodynamic free-energy landscape of crystal formation. Contrary to expectations, we find no special advantage of the proximity of the metastable critical point on the crystallization rates. However, we find that the ultrafast formation of a dense liquid phase causes the crystallization to accelerate both near the metastable critical point and almost everywhere below the fluid-fluid spinodal line. These results unveil three different scenarios for crystallization that could guide the optimization of the process in experiments.

  1. Dielectric functions of Pd and Zr transition metals: an application of Drude-Lorentz models with simulated annealing optimization.

    PubMed

    Vargas, William E

    2017-02-01

    An accepted-probability-controlled simulated annealing (APCSA) method has shown to be a valuable tool to describe, in parametric form, by means of an extended Drude-Lorentz model, the dielectric function of several metals through infrared, visible, and ultraviolet photon energies [Appl. Opt.37, 5271 (1998)APOPAI0003-693510.1364/AO.37.005271]. In this work, an improved APCSA approach is used to estimate the parameters involved in an extended Drude-Lorentz type model which incorporates the dielectric constant due to a background electronic polarization in the Drude term and the normalization of the individual oscillation strengths involved in the Lorentz contributions to the dielectric function. This last approach allows us to introduce a new parameter z to be optimized: the number density ratio, i.e., the ratio between number density of conduction electrons and number density of metal ions. From the optimization of the z value within this novel approach, we evaluate other parameters: electrical resistivity, electron mean free path, effective mass of conduction electrons and relaxation time, Fermi energy, electronic density of states at the Fermi level, and electronic heat capacity coefficient. Application of the model is carried out to describe the dielectric functions of two transition metals, Pd and Zr, through ultraviolet, visible, and infrared photon energies.

  2. Optimization of crystal nucleation close to a metastable fluid-fluid phase transition

    PubMed Central

    Wedekind, Jan; Xu, Limei; Buldyrev, Sergey V.; Stanley, H. Eugene; Reguera, David; Franzese, Giancarlo

    2015-01-01

    The presence of a metastable fluid-fluid critical point is thought to dramatically influence the crystallization pathway, increasing the nucleation rate by many orders of magnitude over the predictions of classical nucleation theory. We use molecular dynamics simulations to study the kinetics of crystallization in the vicinity of this metastable critical point and throughout the metastable fluid-fluid phase diagram. To quantitatively understand how the fluid-fluid phase separation affects the crystal nucleation, we evaluate accurately the kinetics and reconstruct the thermodynamic free-energy landscape of crystal formation. Contrary to expectations, we find no special advantage of the proximity of the metastable critical point on the crystallization rates. However, we find that the ultrafast formation of a dense liquid phase causes the crystallization to accelerate both near the metastable critical point and almost everywhere below the fluid-fluid spinodal line. These results unveil three different scenarios for crystallization that could guide the optimization of the process in experiments PMID:26095898

  3. Tracing the transition path between optimal strategies combinations within a competitive market of innovative industrial products

    NASA Astrophysics Data System (ADS)

    Batzias, Dimitris F.; Pollalis, Yannis A.

    2012-12-01

    In several cases, a competitive market can be simulated by a game, where each company/opponent is referred to as a player. In order to accommodate the fact that each player (alone or with alliances) is working against some others' interest, the rather conservative maximin criterion is frequently used for selecting the strategy or the combination of strategies that yield the best of the worst possible outcomes for each one of the players. Under this criterion, an optimal solution is obtained when neither player finds it beneficial to alter his strategy, which means that an equilibrium has been achieved, giving also the value of the game. If conditions change as regards a player, e.g., because of either achieving an unexpected successful result in developing an innovative industrial product or obtaining higher liquidity permitting him to increase advertisement in order to acquire a larger market share, then a new equilibrium is reached. The identification of the path between the old and the new equilibrium points may prove to be valuable for investigating the robustness of the solution by means of sensitivity analysis, since uncertainty plays a critical role in this situation, where evaluation of the payoff matrix is usually based on experts' estimates. In this work, the development of a standard methodology (including 16 activity stages and 7 decision nodes) for tracing this path is presented while a numerical implementation follows to prove its functionality.

  4. Optimism

    PubMed Central

    Carver, Charles S.; Scheier, Michael F.; Segerstrom, Suzanne C.

    2010-01-01

    Optimism is an individual difference variable that reflects the extent to which people hold generalized favorable expectancies for their future. Higher levels of optimism have been related prospectively to better subjective well-being in times of adversity or difficulty (i.e., controlling for previous well-being). Consistent with such findings, optimism has been linked to higher levels of engagement coping and lower levels of avoidance, or disengagement, coping. There is evidence that optimism is associated with taking proactive steps to protect one's health, whereas pessimism is associated with health-damaging behaviors. Consistent with such findings, optimism is also related to indicators of better physical health. The energetic, task-focused approach that optimists take to goals also relates to benefits in the socioeconomic world. Some evidence suggests that optimism relates to more persistence in educational efforts and to higher later income. Optimists also appear to fare better than pessimists in relationships. Although there are instances in which optimism fails to convey an advantage, and instances in which it may convey a disadvantage, those instances are relatively rare. In sum, the behavioral patterns of optimists appear to provide models of living for others to learn from. PMID:20170998

  5. Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

    PubMed Central

    Roy, Sudeshna; Šileikytė, Justina; Schiavone, Marco; Neuenswander, Benjamin; Argenton, Francesco; Aubé, Jeffrey; Hedrick, Michael P.; Chung, Thomas D. Y.

    2015-01-01

    The mitochondrial permeability transition pore (mtPTP) is a Ca2+-requiring mega-channel which, under pathological conditions, leads to the deregulated release of Ca2+ and mitochondrial dysfunction, ultimately resulting in cell death. Although the mtPTP is a potential therapeutic target for many human pathologies, its potential as a drug target is currently unrealized. Herein we describe an optimization effort initiated around hit 1, 5-(3-hydroxyphenyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide, which was found to possess promising inhibitory activity against mitochondrial swelling (EC50 < 0.39 µm) and showed no interference on the inner mitochondrial membrane potential (rhodamine 123 uptake EC50 > 100 µm). This enabled the construction of a series of picomolar mtPTP inhibitors that also potently increase the calcium retention capacity of the mitochondria. Finally, the therapeutic potential and in vivo efficacy of one of the most potent analogues, N-(3-chloro-2-methylphenyl)-5-(4-fluoro-3-hydroxyphenyl)isoxazole-3-carboxamide (60), was validated in a biologically relevant zebrafish model of collagen VI congenital muscular dystrophies. PMID:26286375

  6. Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.

    PubMed

    Roy, Sudeshna; Šileikytė, Justina; Schiavone, Marco; Neuenswander, Benjamin; Argenton, Francesco; Aubé, Jeffrey; Hedrick, Michael P; Chung, Thomas D Y; Forte, Michael A; Bernardi, Paolo; Schoenen, Frank J

    2015-10-01

    The mitochondrial permeability transition pore (mtPTP) is a Ca(2+) -requiring mega-channel which, under pathological conditions, leads to the deregulated release of Ca(2+) and mitochondrial dysfunction, ultimately resulting in cell death. Although the mtPTP is a potential therapeutic target for many human pathologies, its potential as a drug target is currently unrealized. Herein we describe an optimization effort initiated around hit 1, 5-(3-hydroxyphenyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide, which was found to possess promising inhibitory activity against mitochondrial swelling (EC50 <0.39 μM) and showed no interference on the inner mitochondrial membrane potential (rhodamine 123 uptake EC50 >100 μM). This enabled the construction of a series of picomolar mtPTP inhibitors that also potently increase the calcium retention capacity of the mitochondria. Finally, the therapeutic potential and in vivo efficacy of one of the most potent analogues, N-(3-chloro-2-methylphenyl)-5-(4-fluoro-3-hydroxyphenyl)isoxazole-3-carboxamide (60), was validated in a biologically relevant zebrafish model of collagen VI congenital muscular dystrophies.

  7. Muscle activities during walking and running at energetically optimal transition speed under normobaric hypoxia on gradient slopes

    PubMed Central

    Fukuoka, Yoshiyuki; Horiuchi, Masahiro

    2017-01-01

    Energy cost of transport per unit distance (CoT; J·kg-1·km-1) displays a U-shaped fashion in walking and a linear fashion in running as a function of gait speed (v; km·h-1). There exists an intersection between U-shaped and linear CoT-v relationships, being termed energetically optimal transition speed (EOTS; km·h-1). Combined effects of gradient and moderate normobaric hypoxia (15.0% O2) were investigated when walking and running at the EOTS in fifteen young males. The CoT values were determined at eight walking speeds (2.4–7.3 km·h-1) and four running speeds (7.3–9.4 km·h-1) on level and gradient slopes (±5%) at normoxia and hypoxia. Since an alteration of tibialis anterior (TA) activity has been known as a trigger for gait transition, electromyogram was recorded from TA and its antagonists (gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)) for about 30 steps during walking and running corresponding to the individual EOTS in each experimental condition. Mean power frequency (MPF; Hz) of each muscle was quantified to evaluate alterations of muscle fiber recruitment pattern. The EOTS was not significantly different between normoxia and hypoxia on any slopes (ranging from 7.412 to 7.679 km·h-1 at normoxia and 7.516 to 7.678 km·h-1 at hypoxia) due to upward shifts (enhanced metabolic rate) of both U-shaped and linear CoT-v relationships at hypoxia. GM, but not GL, activated more when switching from walking to running on level and gentle downhill slopes. Significant decreases in the muscular activity and/or MPF were observed only in the TA when switching the gait pattern. Taken together, the EOTS was not slowed by moderate hypoxia in the population of this study. Muscular activities of lower leg extremities and those muscle fiber recruitment patterns are dependent on the gradient when walking and running at the EOTS. PMID:28301525

  8. Differential transition-state stabilization in enzyme catalysis: quantum chemical analysis of interactions in the chorismate mutase reaction and prediction of the optimal catalytic field.

    PubMed

    Szefczyk, Borys; Mulholland, Adrian J; Ranaghan, Kara E; Sokalski, W Andrzej

    2004-12-15

    Chorismate mutase is a key model system in the development of theories of enzyme catalysis. To analyze the physical nature of catalytic interactions within the enzyme active site and to estimate the stabilization of the transition state (TS) relative to the substrate (differential transition state stabilization, DTSS), we have carried out nonempirical variation-perturbation analysis of the electrostatic, exchange, delocalization, and correlation interactions of the enzyme-bound substrate and transition-state structures derived from ab initio QM/MM modeling of Bacillus subtilis chorismate mutase. Significant TS stabilization by approximately -23 kcal/mol [MP2/6-31G(d)] relative to the bound substrate is in agreement with that of previous QM/MM modeling and contrasts with suggestions that catalysis by this enzyme arises purely from conformational selection effects. The most important contributions to DTSS come from the residues, Arg90, Arg7, Glu78, a crystallographic water molecule, Arg116, and Arg63, and are dominated by electrostatic effects. Analysis of the differential electrostatic potential of the TS and substrate allows calculation of the catalytic field, predicting the optimal location of charged groups to achieve maximal DTSS. Comparison with the active site of the enzyme from those of several species shows that the positions of charged active site residues correspond closely to the optimal catalytic field, showing that the enzyme has evolved specifically to stabilize the TS relative to the substrate.

  9. SANS study of vortex lattice structural transition in optimally doped (Ba1-x K x )Fe2As2

    NASA Astrophysics Data System (ADS)

    Demirdiş, S.; van der Beek, C. J.; Mühlbauer, S.; Su, Y.; Wolf, Th

    2016-10-01

    Small-angle neutron scattering on high quality single crystalline Ba1-x K x Fe2As2 reveals the transition from a low-field vortex solid phase with orientational order to a vortex polycrystal at high magnetic field. The vortex order-disorder transition is correlated with the second-peak feature in isothermal hysteresis loops, and is interpreted in terms of the generation of supplementary vortex solid dislocations. The sharp drop of the structure factor above the second peak field is explained by the dynamics of freezing of the vortex ensemble in the high field phase.

  10. SANS study of vortex lattice structural transition in optimally doped (Ba1-x K x )Fe2As2.

    PubMed

    Demirdiş, S; van der Beek, C J; Mühlbauer, S; Su, Y; Wolf, Th

    2016-10-26

    Small-angle neutron scattering on high quality single crystalline Ba1-x K x Fe2As2 reveals the transition from a low-field vortex solid phase with orientational order to a vortex polycrystal at high magnetic field. The vortex order-disorder transition is correlated with the second-peak feature in isothermal hysteresis loops, and is interpreted in terms of the generation of supplementary vortex solid dislocations. The sharp drop of the structure factor above the second peak field is explained by the dynamics of freezing of the vortex ensemble in the high field phase.

  11. Absence of an Appreciable Iron Isotope Effect on the Transition Temperature of the Optimally Doped SmFeAsO1-y Superconductor

    NASA Astrophysics Data System (ADS)

    Shirage, Parasharam M.; Miyazawa, Kiichi; Kihou, Kunihiro; Kito, Hijiri; Yoshida, Yoshiyuki; Tanaka, Yasumoto; Eisaki, Hiroshi; Iyo, Akira

    2010-07-01

    We report the iron (Fe) isotope effect on the transition temperature (Tc) in oxygen-deficient SmFeAsO1-y, a 50-K-class, Fe-based superconductor. For the optimally doped samples with Tc=54K, a change of the average atomic mass of Fe (MFe) causes a negligibly small shift in Tc, with the Fe isotope coefficient (αFe) as small as -0.024±0.015 (where αFe=-dln⁡Tc/dln⁡MFe). This result contrasts with the finite, inverse isotope shift observed in optimally doped (Ba,K)Fe2As2, indicating that the contribution of the electron-phonon interaction markedly differs between these two Fe-based high-Tc superconductors.

  12. Optimization of the GAFF force field to describe liquid crystal molecules: the path to a dramatic improvement in transition temperature predictions.

    PubMed

    Boyd, Nicola Jane; Wilson, Mark R

    2015-10-14

    The physical properties and phase transitions of thermotropic liquid crystals are highly sensitive to small changes in chemical structure. However, these changes are challenging to model, as both the phase diagram and mesophase properties obtained from fully atomistic simulations are strongly dependent on the force field model employed, and the current generation of chemical force fields has not proved accurate enough to provide reliable predictions of transition temperatures for many liquid crystals. This paper presents a strategy for improving the nematic clearing point, TNI, in atomistic simulations, by systematic optimization of the General Amber Force Field (GAFF) for key mesogenic fragments. We show that with careful optimization of the parameters describing a series of liquid crystal fragment molecules, it is possible to transfer these parameters to larger liquid crystal molecules and make accurate predictions for nematic mesophase formation. This new force field, GAFF-LCFF, is used to predict the nematic-isotropic clearing point to within 5 °C for the nematogen 1,3-benzenedicarboxylic acid,1,3-bis(4-butylphenyl)ester, an improvement of 60 °C over the standard GAFF force field.

  13. Optimization of film synthesized rare earth transition metal permanent magnet systems. Progress report, August 1, 1991--July 31, 1992

    SciTech Connect

    Cadieu, F.J.

    1992-08-01

    Progress is reported in three areas: high coercivity Sm-Fe-Ti-V, Sm-Fe-Zr, and two element Sm-Fe Sm{sub 5}(Fe,T){sub 17} type crystalline phases; ThMn{sub 12} type pseudobinary SmFe{sub 12-x}T{sub x}(0{le}{times}{le}1.5); and sputter process control for the synthesis of precisely textured rare earth-transition metal magnetic films. (DLC)

  14. Stepped MS(All) Relied Transition (SMART): An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules.

    PubMed

    Ye, Hui; Zhu, Lin; Wang, Lin; Liu, Huiying; Zhang, Jun; Wu, Mengqiu; Wang, Guangji; Hao, Haiping

    2016-02-11

    Multiple reaction monitoring (MRM) is a universal approach for quantitative analysis because of its high specificity and sensitivity. Nevertheless, optimization of MRM parameters remains as a time and labor-intensive task particularly in multiplexed quantitative analysis of small molecules in complex mixtures. In this study, we have developed an approach named Stepped MS(All) Relied Transition (SMART) to predict the optimal MRM parameters of small molecules. SMART requires firstly a rapid and high-throughput analysis of samples using a Stepped MS(All) technique (sMS(All)) on a Q-TOF, which consists of serial MS(All) events acquired from low CE to gradually stepped-up CE values in a cycle. The optimal CE values can then be determined by comparing the extracted ion chromatograms for the ion pairs of interest among serial scans. The SMART-predicted parameters were found to agree well with the parameters optimized on a triple quadrupole from the same vendor using a mixture of standards. The parameters optimized on a triple quadrupole from a different vendor was also employed for comparison, and found to be linearly correlated with the SMART-predicted parameters, suggesting the potential applications of the SMART approach among different instrumental platforms. This approach was further validated by applying to simultaneous quantification of 31 herbal components in the plasma of rats treated with a herbal prescription. Because the sMS(All) acquisition can be accomplished in a single run for multiple components independent of standards, the SMART approach are expected to find its wide application in the multiplexed quantitative analysis of complex mixtures.

  15. β- transitions of 16 7N9 → 16 8O8 with optimized SDI residual interaction using pnTDA and TDA approximations

    NASA Astrophysics Data System (ADS)

    Pahlavani, M. R.; Firoozi, B.

    2015-11-01

    Within a developed particle-hole approach, a systematic study of the β- transition from the ground state of the 16N nucleus to the ground and some exited states of the 16O nucleus has been carried out. The energy spectrum and the wave functions of pure configuration of the 16N and 16O nuclei are numerically obtained using the mean-field shell model with respect to the Woods-Saxon nuclear potential accompanying spin-orbit and Coulomb interaction. Considering SDI residual interaction, mixed configuration of ground and excited pnTDA and TDA states are extracted for the aforementioned nucleus. These energy spectra and corresponding eigenstates are highly correspondent to the experimental energy spectrum and eigenstates after adjusting the residual potential parameters using the Nelder-Mead (NM) algorithm. In this approach, the endpoint energy, log ft and the partial half-lives of some possible transitions are calculated. The obtained results using the optimized SDI approach are reasonably close to the available experimental data.

  16. In silico optimization of phase-change materials for digital memories: a survey of first-row transition-metal dopants for Ge2Sb2Te5

    NASA Astrophysics Data System (ADS)

    Skelton, J. M.; Elliott, S. R.

    2013-05-01

    Phase-change materials are the alloys at the heart of an emerging class of next-generation, non-volatile digital memory technologies. However, the widely studied Ge-Sb-Te system possesses several undesirable properties, and enhancing its properties, e.g. by doping, is an area of active research. Various first-row transition-metal dopants have been shown to impart useful property enhancements, but a systematic study of the entire period has yet to be undertaken, and little has been done to investigate their interaction with the host material at the atomic level. We have carried out first-principles computer simulations of the complete phase-change cycle in Ge2Sb2Te5 doped with each of the ten first-row transition metals. In this article, we present a comprehensive survey of the electronic, magnetic and optical properties of these doped materials. We discuss in detail their atomic-level structure, and relate the microscopic behaviours of the dopant atoms to their influence on the Ge2Sb2Te5 host. By considering an entire family of similar materials, we identify trends and patterns which might be used to predict suitable dopants for optimizing materials for specific phase-change applications. The computational method employed here is general, and this materials-discovery approach could be applied in the future to study other families of potential dopants for such materials.

  17. In silico optimization of phase-change materials for digital memories: a survey of first-row transition-metal dopants for Ge₂Sb₂Te₅.

    PubMed

    Skelton, J M; Elliott, S R

    2013-05-22

    Phase-change materials are the alloys at the heart of an emerging class of next-generation, non-volatile digital memory technologies. However, the widely studied Ge-Sb-Te system possesses several undesirable properties, and enhancing its properties, e.g. by doping, is an area of active research. Various first-row transition-metal dopants have been shown to impart useful property enhancements, but a systematic study of the entire period has yet to be undertaken, and little has been done to investigate their interaction with the host material at the atomic level. We have carried out first-principles computer simulations of the complete phase-change cycle in Ge2Sb2Te5 doped with each of the ten first-row transition metals. In this article, we present a comprehensive survey of the electronic, magnetic and optical properties of these doped materials. We discuss in detail their atomic-level structure, and relate the microscopic behaviours of the dopant atoms to their influence on the Ge2Sb2Te5 host. By considering an entire family of similar materials, we identify trends and patterns which might be used to predict suitable dopants for optimizing materials for specific phase-change applications. The computational method employed here is general, and this materials-discovery approach could be applied in the future to study other families of potential dopants for such materials.

  18. Laser pulse design using optimal control theory-based adaptive simulated annealing technique: vibrational transitions and photo-dissociation

    NASA Astrophysics Data System (ADS)

    Nath, Bikram; Mondal, Chandan Kumar

    2014-08-01

    We have designed and optimised a combined laser pulse using optimal control theory-based adaptive simulated annealing technique for selective vibrational excitations and photo-dissociation. Since proper choice of pulses for specific excitation and dissociation phenomena is very difficult, we have designed a linearly combined pulse for such processes and optimised the different parameters involved in those pulses so that we can get an efficient combined pulse. The technique makes us free from choosing any arbitrary type of pulses and makes a ground to check their suitability. We have also emphasised on how we can improve the performance of simulated annealing technique by introducing an adaptive step length of the different variables during the optimisation processes. We have also pointed out on how we can choose the initial temperature for the optimisation process by introducing heating/cooling step to reduce the annealing steps so that the method becomes cost effective.

  19. Study on traffic states and jamming transitions for two-lane highway including a bus by using a model with calibrated optimal velocity function

    NASA Astrophysics Data System (ADS)

    Li, Zhipeng; Yi, Yi

    2014-07-01

    In this paper, traffic states and jamming transitions on two-lane highway including a bus are studied by using a car following model with a calibrated optimal velocity function. We derive a new flow-density diagram with four distinctly separated traffic states, which is different from that of the earlier study obtained by applying the OVM with theoretical optimal velocity function. The spatio-temporal diagrams are presented to illustrate phase characteristics of each traffic state. It is found that the phase characteristic features of two of four states are different from any state of the earlier result, and traffic flow of state 2 and state 3 can reproduce some characteristics observed from empirical investigations such as centralized lane-changing, hanging tail of cluster, and synchronized flow. In addition, we have clarified the lane-changing behaviors and their effects on two-lane traffic flow including a bus. It is shown that the velocity oscillations behind the bus can help the lane-changing in state 2 and the behaviors of lane-changing are the important reason of forming of the synchronized flow in state 3. It is also concluded that lane-changing can only improve the current in the region of middle density.

  20. Strong Combination of Ant Colony Optimization with Constraint Programming Optimization

    NASA Astrophysics Data System (ADS)

    Khichane, Madjid; Albert, Patrick; Solnon, Christine

    We introduce an approach which combines ACO (Ant Colony Optimization) and IBM ILOG CP Optimizer for solving COPs (Combinatorial Optimization Problems). The problem is modeled using the CP Optimizer modeling API. Then, it is solved in a generic way by a two-phase algorithm. The first phase aims at creating a hot start for the second: it samples the solution space and applies reinforcement learning techniques as implemented in ACO to create pheromone trails. During the second phase, CP Optimizer performs a complete tree search guided by the pheromone trails previously accumulated. The first experimental results on knapsack, quadratic assignment and maximum independent set problems show that this new algorithm enhances the performance of CP Optimizer alone.

  1. Optimally combined confidence limits

    NASA Astrophysics Data System (ADS)

    Janot, P.; Le Diberder, F.

    1998-02-01

    An analytical and optimal procedure to combine statistically independent sets of confidence levels on a quantity is presented. This procedure does not impose any constraint on the methods followed by each analysis to derive its own limit. It incorporates the a priori statistical power of each of the analyses to be combined, in order to optimize the overall sensitivity. It can, in particular, be used to combine the mass limits obtained by several analyses searching for the Higgs boson in different decay channels, with different selection efficiencies, mass resolution and expected background. It can also be used to combine the mass limits obtained by several experiments (e.g. ALEPH, DELPHI, L3 and OPAL, at LEP 2) independently of the method followed by each of these experiments to derive their own limit. A method to derive the limit set by one analysis is also presented, along with an unbiased prescription to optimize the expected mass limit in the no-signal-hypothesis.

  2. Integrated Network Decompositions and Dynamic Programming for Graph Optimization (INDDGO)

    SciTech Connect

    2012-05-31

    The INDDGO software package offers a set of tools for finding exact solutions to graph optimization problems via tree decompositions and dynamic programming algorithms. Currently the framework offers serial and parallel (distributed memory) algorithms for finding tree decompositions and solving the maximum weighted independent set problem. The parallel dynamic programming algorithm is implemented on top of the MADNESS task-based runtime.

  3. Optimization on magnetic transitions and magnetostriction in TbxDyyNdz(Fe0.9Co0.1)1.93 compounds

    NASA Astrophysics Data System (ADS)

    Hu, C. C.; Shi, Y. G.; Shi, D. N.; Zhou, X. G.; Fan, J. Y.; Lv, L. Y.; Tang, S. L.

    2013-10-01

    The structure, magnetic transitions, and magnetostriction of TbxDyyNdz(Fe0.9Co0.1)1.93 polycrystalline compounds have been investigated, with the ratio of x, y, and z spanning the line of minimum magnetic anisotropy. Anisotropy compensation with lower Tb content was realized in Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 compound. The spin configuration diagram accompanied with different crystal structures was constructed to illustrate the arrangement for the easy magnetization direction and crystal structure. An optimized effect on magnetostriction especially at the relatively low field of 1 kOe (197 ppm) was observed in Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 compound, which is about two times larger than that of the sample free of Nd (62 ppm). Meanwhile, the polycrystalline saturation magnetostriction (λs=945 ppm) of Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 is even much larger than that of the Ho-doped multicomponent single crystal compound Tb0.2Dy0.22Ho0.58Fe2 (λs=530 ppm). Low content of heavy rare earth Tb, high Curie temperature, and large ratio between magnetostriction and the absolute value of the first anisotropy constant λa/|K1| were obtained in Tb0.253Dy0.657Nd0.09(Fe0.9Co0.1)1.93 compound, which may make it a potential material for magnetostrictive application.

  4. Variational Transition State Theory

    SciTech Connect

    Truhlar, Donald G.

    2016-09-29

    This is the final report on a project involving the development and applications of variational transition state theory. This project involved the development of variational transition state theory for gas-phase reactions, including optimized multidimensional tunneling contributions and the application of this theory to gas-phase reactions with a special emphasis on developing reaction rate theory in directions that are important for applications to combustion. The development of variational transition state theory with optimized multidimensional tunneling as a useful computational tool for combustion kinetics involved eight objectives.

  5. Gravitationally induced quantum transitions

    NASA Astrophysics Data System (ADS)

    Landry, A.; Paranjape, M. B.

    2016-06-01

    In this paper, we calculate the probability for resonantly inducing transitions in quantum states due to time-dependent gravitational perturbations. Contrary to common wisdom, the probability of inducing transitions is not infinitesimally small. We consider a system of ultracold neutrons, which are organized according to the energy levels of the Schrödinger equation in the presence of the Earth's gravitational field. Transitions between energy levels are induced by an oscillating driving force of frequency ω . The driving force is created by oscillating a macroscopic mass in the neighborhood of the system of neutrons. The neutron lifetime is approximately 880 sec while the probability of transitions increases as t2. Hence, the optimal strategy is to drive the system for two lifetimes. The transition amplitude then is of the order of 1.06 ×10-5, and hence with a million ultracold neutrons, one should be able to observe transitions.

  6. Transition Planning

    ERIC Educational Resources Information Center

    Statfeld, Jenna L.

    2011-01-01

    Post-school transition is the movement of a child with disabilities from school to activities that occur after the completion of school. This paper provides information about: (1) post-school transition; (2) transition plan; (3) transition services; (4) transition planning; (5) vocational rehabilitation services; (6) services that are available…

  7. Parallel Algorithms for Graph Optimization using Tree Decompositions

    SciTech Connect

    Sullivan, Blair D; Weerapurage, Dinesh P; Groer, Christopher S

    2012-06-01

    Although many $\\cal{NP}$-hard graph optimization problems can be solved in polynomial time on graphs of bounded tree-width, the adoption of these techniques into mainstream scientific computation has been limited due to the high memory requirements of the necessary dynamic programming tables and excessive runtimes of sequential implementations. This work addresses both challenges by proposing a set of new parallel algorithms for all steps of a tree decomposition-based approach to solve the maximum weighted independent set problem. A hybrid OpenMP/MPI implementation includes a highly scalable parallel dynamic programming algorithm leveraging the MADNESS task-based runtime, and computational results demonstrate scaling. This work enables a significant expansion of the scale of graphs on which exact solutions to maximum weighted independent set can be obtained, and forms a framework for solving additional graph optimization problems with similar techniques.

  8. Structural and magnetic phase transitions near optimal superconductivity in BaFe2(As1-xPx)2

    SciTech Connect

    Hu, Ding; Lu, Xingye; Zhang, Wenliang; Luo, Huiqian; Li, Shiliang; Wang, Peipei; Chen, Genfu; Han, Fei; Banjara, Shree R.; Sapkota, A.; Kreyssig, A.; Goldman, A. I.; Yamani, Z.; Niedermayer, Christof; Skoulatos, Markos; Georgii, Robert; Keller, T.; Wang, Pengshuai; Yu, Weiqiang; Dai, Pengcheng

    2015-04-17

    In this study, we use nuclear magnetic resonance (NMR), high-resolution x-ray and neutron scattering to study structural and magnetic phase transitions in phosphorus-doped BaFe2(As1-xPx)2. Thus, previous transport, NMR, specific heat, and magnetic penetration depth measurements have provided compelling evidence for the presence of a quantum critical point (QCP) near optimal superconductivity at x = 0.3. However, we show that the tetragonal-to-orthorhombic structural (Ts) and paramagnetic to antiferromagnetic (AF, TN) transitions in BaFe2(As1-xPx)2 are always coupled and approach to TN ≈ Ts ≥ Tc (≈ 29 K) for x = 0.29 before vanishing abruptly for x ≥ 0.3. These results suggest that AF order in BaFe2(As1-xPx)2 disappears in a weakly first order fashion near optimal superconductivity, much like the electron-doped iron pnictides with an avoided QCP.

  9. Numerical optimization of the electrical characteristics of an EUV laser on 3 p-3 s transition in neonlike argon ions in low-inductance capillary-type discharge

    NASA Astrophysics Data System (ADS)

    Burtsev, V. A.; Kalinin, N. V.; Vaganov, S. A.

    2017-01-01

    Electrical characteristics of low-inductance capillary-type discharge have been determined by numerical model calculations, which ensure high efficiency of energy supply to a plasma column with an aspect ratio of 1: 100. The EUV argon laser based on this discharge provides a gain of g + > 1 cm-1 on the operating transition and ensures single-pass spontaneous lasing with g + l > 25 (where l is the active medium length).

  10. Assessment of density functional theory optimized basis sets for gradient corrected functionals to transition metal systems: the case of small Nin (n

    PubMed

    López Arvizu, Gregorio; Calaminici, Patrizia

    2007-05-21

    Density functional calculations have been performed for small nickel clusters, Ni(n), Ni(n) (+), and Ni(n)(-) (noptimized for generalized gradient approximation (GGA) as well as an all-electron basis set optimized for the local density approximation were employed. For both neutral and charged systems, several isomers and different multiplicities were studied in order to determine the lowest energy structures. A vibrational analysis was performed in order to characterize these isomers. Structural parameters, harmonic frequencies, binding energies, ionization potentials, and electron affinities are reported. This work shows that the employed GGA basis sets for the nickel atom are important for the correct prediction of the ground state structures of small nickel clusters and that the structural assignment of these systems can be performed, with a good resolution, over the ionization potential.

  11. Improved metal-insulator-transition characteristics of ultrathin VO{sub 2} epitaxial films by optimized surface preparation of rutile TiO{sub 2} substrates

    SciTech Connect

    Martens, Koen; Aetukuri, Nagaphani; Jeong, Jaewoo; Samant, Mahesh G.; Parkin, Stuart S. P.

    2014-02-24

    Key to the growth of epitaxial, atomically thin films is the preparation of the substrates on which they are deposited. Here, we report the growth of atomically smooth, ultrathin films of VO{sub 2} (001), only ∼2 nm thick, which exhibit pronounced metal-insulator transitions, with a change in resistivity of ∼500 times, at a temperature that is close to that of films five times thicker. These films were prepared by pulsed laser deposition on single crystalline TiO{sub 2}(001) substrates that were treated by dipping in acetone, HCl and HF in successive order, followed by an anneal at 700–750  °C in flowing oxygen. This pretreatment removes surface contaminants, TiO{sub 2} defects, and provides a terraced, atomically smooth surface.

  12. Work transitions.

    PubMed

    Fouad, Nadya A; Bynner, John

    2008-01-01

    Individuals make choices in, and adjust to, a world of work that is often a moving target. Because work is so central to human functioning, and transitions in and out of work can have major mental health repercussions, the authors argue that applied psychologists in health services need to understand those transitions. This article focuses on the different types of transition throughout a person's working life and the resources needed at different stages to ensure the success of these transitions. The authors start by examining the roles of capability and adaptability in supporting and facilitating adjustment to work transitions and their relation to identity development. They then examine the role of social and institutional contexts in shaping work transitions and their outcomes. The authors focus on voluntary versus involuntary transitions and then broaden the lens in discussing the policy implications of research on work transitions.

  13. The copper intrauterine device for emergency contraception: an opportunity to provide the optimal emergency contraception method and transition to highly effective contraception.

    PubMed

    Dermish, Amna I; Turok, David K

    2013-07-01

    Worldwide, 40% of all pregnancies are unintended. Widespread, over-the-counter availability of oral emergency contraception (EC) has not reduced unintended pregnancy rates. The EC visit presents an opportunity to initiate a highly effective method of contraception in a population at high risk of unintended pregnancy who are actively seeking to avoid pregnancy. The copper intrauterine device (IUD), the most effective method of EC, continues to provide contraception as effective as sterilization for up to 12 years, and it should be offered as the first-line method of EC wherever possible. Increased demand for and supply of the copper IUD for EC may have an important role in reducing rates of unintended pregnancy. The EC visit should include access to the copper IUD as optimal care but should ideally include access to all highly effective methods of contraception.

  14. The puhE gene of Rhodobacter capsulatus is needed for optimal transition from aerobic to photosynthetic growth and encodes a putative negative modulator of bacteriochlorophyll production.

    PubMed

    Aklujkar, Muktak; Prince, Roger C; Beatty, J Thomas

    2005-05-15

    A conserved orf of previously unknown function (herein designated as puhE) is located 3' of the reaction centre H (puhA) gene in purple photosynthetic bacteria, in the order puhABCE in Rhodobacter capsulatus. Disruptions of R. capsulatus puhE resulted in a long lag in the growth of photosynthetic cultures inoculated with cells grown under high aeration, and increased the level of the peripheral antenna, light-harvesting complex 2 (LH2). The amount of the photosynthetic reaction centre (RC) and its core antenna, light-harvesting complex 1 (LH1), was reduced; however, there was no decrease in expression of a lacZ reporter fused to the puf (RC and LH1) promoter, in RC assembly in the absence of LH1, or in LH1 assembly in the absence of the RC. In strains that lack LH2, disruption of puhE increased the in vivo absorption at 780 nm, which we attribute to excess bacteriochlorophyll a (BChl) pigment production. This effect was seen in the presence and absence of PufQ, a protein that stimulates BChl biosynthesis. Expression of puhE from a plasmid reduced A(780) production in puhE mutants. We suggest that PuhE modulates BChl biosynthesis independently of PufQ, and that the presence of excess BChl in PuhE(-)LH2(+) strains results in excess LH2 assembly and also interferes with the adaptation of cells during the transition from aerobic respiratory to anaerobic photosynthetic growth.

  15. Optimal search strategies on complex multi-linked networks

    PubMed Central

    Di Patti, Francesca; Fanelli, Duccio; Piazza, Francesco

    2015-01-01

    In this paper we consider the problem of optimal search strategies on multi-linked networks, i.e. graphs whose nodes are endowed with several independent sets of links. We focus preliminarily on agents randomly hopping along the links of a graph, with the additional possibility of performing non-local hops to randomly chosen nodes with a given probability. We show that an optimal combination of the two jump rules exists that maximises the efficiency of target search, the optimum reflecting the topology of the network. We then generalize our results to multi-linked networks with an arbitrary number of mutually interfering link sets. PMID:25950716

  16. Transition States and transition state analogue interactions with enzymes.

    PubMed

    Schramm, Vern L

    2015-04-21

    evolved enzymatic geometry to form the transition state. Evolution to efficient catalysis optimized this geometry and its stabilization by a transition state mimic results in tight binding. Release rates of transition state analogues are orders of magnitude slower than product release in normal catalytic function. During catalysis, product release is facilitated by altered chemistry. Compared to the weak associations found in Michaelis complexes, transition state analogues involve strong interactions related to those in the transition state. Optimum binding of transition state analogues occurs when the complex retains the system motions intrinsic to transition state formation. Conserved dynamic motion retains the entropic components of inhibitor complexes, improving the thermodynamics of analogue binding.

  17. Transitional Care

    ERIC Educational Resources Information Center

    Naylor, Mary; Keating, Stacen A.

    2008-01-01

    Transitional care encompasses a broad range of services and environments designed to promote the safe and timely passage of patients between levels of health care and across care settings. High-quality transitional care is especially important for older adults with multiple chronic conditions and complex therapeutic regimens, as well as for their…

  18. Optimally Stopped Optimization

    NASA Astrophysics Data System (ADS)

    Vinci, Walter; Lidar, Daniel A.

    2016-11-01

    We combine the fields of heuristic optimization and optimal stopping. We propose a strategy for benchmarking randomized optimization algorithms that minimizes the expected total cost for obtaining a good solution with an optimal number of calls to the solver. To do so, rather than letting the objective function alone define a cost to be minimized, we introduce a further cost-per-call of the algorithm. We show that this problem can be formulated using optimal stopping theory. The expected cost is a flexible figure of merit for benchmarking probabilistic solvers that can be computed when the optimal solution is not known and that avoids the biases and arbitrariness that affect other measures. The optimal stopping formulation of benchmarking directly leads to a real-time optimal-utilization strategy for probabilistic optimizers with practical impact. We apply our formulation to benchmark simulated annealing on a class of maximum-2-satisfiability (MAX2SAT) problems. We also compare the performance of a D-Wave 2X quantum annealer to the Hamze-Freitas-Selby (HFS) solver, a specialized classical heuristic algorithm designed for low-tree-width graphs. On a set of frustrated-loop instances with planted solutions defined on up to N =1098 variables, the D-Wave device is 2 orders of magnitude faster than the HFS solver, and, modulo known caveats related to suboptimal annealing times, exhibits identical scaling with problem size.

  19. Transition metals

    PubMed Central

    Rodrigo-Moreno, Ana; Poschenrieder, Charlotte; Shabala, Sergey

    2013-01-01

    Transition metals such as Iron (Fe) and Copper (Cu) are essential for plant cell development. At the same time, due their capability to generate hydroxyl radicals they can be potentially toxic to plant metabolism. Recent works on hydroxyl-radical activation of ion transporters suggest that hydroxyl radicals generated by transition metals could play an important role in plant growth and adaptation to imbalanced environments. In this mini-review, the relation between transition metals uptake and utilization and oxidative stress-activated ion transport in plant cells is analyzed, and a new model depicting both apoplastic and cytosolic mode of ROS signaling to plasma membrane transporters is suggested. PMID:23333964

  20. Structural transitions in clusters.

    PubMed

    Hartke, Bernd

    2002-05-03

    If one adds more particles to a cluster, the energetically optimal structure is neither preserved nor does it change in a continuous fashion. Instead, one finds several cluster size regions where one structural principle dominates almost without exception, and rather narrow boundary regions in-between. The structure of the solid is usually reached only at relatively large sizes, after more than one structural transition. The occurrence of this general phenomenon of size-dependent structural transitions does not seem to depend on the nature of the particles, it is found for atomic, molecular, homogeneous, and heterogeneous clusters alike. Clearly, it is a collective many-body phenomenon which can in principle be calculated but not understood in a fully reductionistic manner. Actual calculations with sufficient accuracy are not feasible today, because of the enormous computational expense, even when unconventional evolutionary algorithms are employed for global geometry optimization. Therefore, simple rules for cluster structures are highly desirable. In fact, we are dealing here not just with the academic quest for linkages between cluster structure and features of the potential energy surface, but structural transitions in clusters are also of immediate relevance for many natural and industrial processes, ranging from crystal growth all the way to nanotechnology. This article provides an exemplary overview of research on this topic, from simple model systems where first qualitative explanations start to be successful, up to more realistic complex systems which are still beyond our understanding.

  1. Optimal domain decomposition strategies

    NASA Technical Reports Server (NTRS)

    Yoon, Yonghyun; Soni, Bharat K.

    1995-01-01

    The primary interest of the authors is in the area of grid generation, in particular, optimal domain decomposition about realistic configurations. A grid generation procedure with optimal blocking strategies has been developed to generate multi-block grids for a circular-to-rectangular transition duct. The focus of this study is the domain decomposition which optimizes solution algorithm/block compatibility based on geometrical complexities as well as the physical characteristics of flow field. The progress realized in this study is summarized in this paper.

  2. Research in bus and rail transit operations

    SciTech Connect

    Chatterjee, A.; Wegmann, F.J.; Ceder, A.; Levinson, H.S.; Hollander, A.

    1989-01-01

    The 10 papers in the report deal with the following areas: Private Sector Involvement in Sponsoring Sunday Bus Service; Optimal Design of Transit Short-Turn Trips; New York City's Unfranchised Buses: Case Study in Deregulation; Critical Factors in Planning Multimodal Passenger Terminals; Use of Travelers' Attitudes in Rail Service Design; Driven, Attended, and Fully Automated Transit; Qualitative Comparison; Impact on Transit Patronage of Cessation or Inauguration of Rail Service; Use of Productivity Factors in Estimating LRT Operating Costs; Simulation Study To Evaluate Spare Ratios in Bus Transit Systems; Statistical Evaluation of Spare Ratio in Transit Rolling Stock.

  3. Presidential Transitions

    DTIC Science & Technology

    2006-06-09

    Podesta for the Heads of Executive Departments and Agencies, “Presidential Transition Guidance,” Nov. 13, 2000. 89 U.S. General Services Administration...2000, presidential election, White House Chief of Staff John Podesta issued a November 13, 2000, memorandum to executive branch agencies stating that

  4. Tessellations & Transitions.

    ERIC Educational Resources Information Center

    Cassidy, Joan

    1998-01-01

    Describes two sixth-grade lessons on the work of M. C. Escher: (1) the first lesson instructs students on tessellations, or tiles that interlock in a repeated pattern; (2) the second lesson explores Escher's drawings of transitions from two- to three-dimensional space. (DSK)

  5. Eliminating Transitions

    ERIC Educational Resources Information Center

    Gallick, Barb; Lee, Lisa

    2010-01-01

    Adults often find themselves transitioning from one activity to another in a short time span. Most of the time, they do not feel they have a lot of control over their schedules, but wish that they could carve out extended time to relax and focus on one project. Picture a group of children in the block area who have spent 15 or 20 minutes building…

  6. Optimizing Locomotion

    NASA Astrophysics Data System (ADS)

    Hosoi, Anette

    2006-11-01

    In this talk we will discuss two optimization topics related to low Reynolds number locomotion: optimal stroke patterns in linked swimmers and optimal fluid material properties in adhesive locomotion. In contrast to many optimization problems, we do not consider geometry, rather we optimize the swimming kinematics or fluid material properties for a given geometrical configuration. In the first case, we begin by optimizing stroke patterns for Purcell's 3-link swimmer. We model the swimmer as a jointed chain of three slender links moving in an inertialess flow. The swimmer is optimized for both efficiency and speed. In the second case, we analyze the adhesive locomotion used by common gastropods such as snails and slugs. Such organisms crawl on a solid substrate by propagating muscular waves of shear stress on a viscoelastic mucus. Using a simple mechanical model, we derive criteria for favorable fluid material properties to lower the energetic cost of locomotion.

  7. Topological Lifshitz transitions

    NASA Astrophysics Data System (ADS)

    Volovik, G. E.

    2017-01-01

    Different types of Lifshitz transitions are governed by topology in momentum space. They involve the topological transitions with the change of topology of Fermi surfaces, Weyl and Dirac points, nodal lines, and also the transitions between the fully gapped states.

  8. Transitions: A Personal Perspective.

    ERIC Educational Resources Information Center

    Wood, Ann Stace

    1995-01-01

    Distinguishes between unchosen transitions (children maturing and leaving, parents aging, companies downsizing) and chosen ones (moving, divorce, marriage, career changes). Describes the steps one goes through: uneasiness, renewed energy, complaining, exploration, partial transition, and the completed transition. (JOW)

  9. Radionuclide transit in esophageal varices

    SciTech Connect

    Yeh, S.H.; Wang, S.J.; Wu, L.C.; Liu, R.S.; Tsai, Y.T.; Chiang, T.T.

    1985-05-01

    This study assessed esophageal motility in patients with esophageal varices by radionuclide transit studies. Data were acquired in list mode after an oral dose of 0.5 mCi Tc-99m sulfur colloid in 10 ml of water in the supine position above a low-energy all-purpose collimator of a gamma camera. The condensed image (CI) superimposed with a centroid curve was also produced in each case. Twenty-five normal subjects (N) and 32 patients (pts) with esophageal varices by endoscopy (large varices in Grades IV and V in 8 and small varices in Grade III or less in 24) were studied. TMTT, RTT, RF, and RI were all significantly increased in pts as compared to N. Especially, the transit time for the middle third (6.7 +- 2.6 sec vs 3.5 +- 0.9 sec in N, rho < 0.005) had the optimal sensitivy and specificity of 88% each at the cutoff value of 4.2 sec as determined by ROC analysis. In summary, radionuclide transit disorders occur in the majority of pts with esopageal varices. The middle RTT and CI are both optimal in sensitivity and specificity for detecting the abnormalities.

  10. On the Bellman's principle of optimality

    NASA Astrophysics Data System (ADS)

    Gross, Eitan

    2016-11-01

    Bellman's equation is widely used in solving stochastic optimal control problems in a variety of applications including investment planning, scheduling problems and routing problems. Building on Markov decision processes for stationary policies, we present a new proof for Bellman's equation of optimality. Our proof rests its case on the availability of an explicit model of the environment that embodies transition probabilities and associated costs.

  11. Tips for Transition

    ERIC Educational Resources Information Center

    Kellems, Ryan, Comp.; Morningstar, Mary E., Comp.

    2009-01-01

    The Tips for Transition contains 134 Transition Tips submitted from all over the country by practitioners. The purpose of the Tips was to identify grassroots transition practices being used by practitioners. Tips are categorized into the following domains: (1) Transition Planning; (2) Student Involvement; (3) Family Involvement; (4) Curriculum and…

  12. Nonconvex optimization and jamming

    NASA Astrophysics Data System (ADS)

    Kallus, Yoav

    Recent work on the jamming transition of particles with short-range interactions has drawn connections with models based on minimization problems with linear inequality constraints and a concave objective. These properties reduce the continuous optimization problem to a discrete search among the corners of the feasible polytope. I will discuss results from simulations of models with and without quenched disorder, exhibiting critical power laws, scaling collapse, and protocol dependence. These models are also well-suited for study using tools of algebraic topology, which I will discuss briefly. Supported by an Omidyar Fellowship at the Santa Fe Institute.

  13. Optimality in neuromuscular systems.

    PubMed

    Theodorou, Evangelos; Valero-Cuevas, Francisco J

    2010-01-01

    We provide an overview of optimal control methods to nonlinear neuromuscular systems and discuss their limitations. Moreover we extend current optimal control methods to their application to neuromuscular models with realistically numerous musculotendons; as most prior work is limited to torque-driven systems. Recent work on computational motor control has explored the used of control theory and estimation as a conceptual tool to understand the underlying computational principles of neuromuscular systems. After all, successful biological systems regularly meet conditions for stability, robustness and performance for multiple classes of complex tasks. Among a variety of proposed control theory frameworks to explain this, stochastic optimal control has become a dominant framework to the point of being a standard computational technique to reproduce kinematic trajectories of reaching movements (see [12]) In particular, we demonstrate the application of optimal control to a neuromuscular model of the index finger with all seven musculotendons producing a tapping task. Our simulations include 1) a muscle model that includes force- length and force-velocity characteristics; 2) an anatomically plausible biomechanical model of the index finger that includes a tendinous network for the extensor mechanism and 3) a contact model that is based on a nonlinear spring-damper attached at the end effector of the index finger. We demonstrate that it is feasible to apply optimal control to systems with realistically large state vectors and conclude that, while optimal control is an adequate formalism to create computational models of neuro-musculoskeletal systems, there remain important challenges and limitations that need to be considered and overcome such as contact transitions, curse of dimensionality, and constraints on states and controls.

  14. Distributed Optimization

    NASA Technical Reports Server (NTRS)

    Macready, William; Wolpert, David

    2005-01-01

    We demonstrate a new framework for analyzing and controlling distributed systems, by solving constrained optimization problems with an algorithm based on that framework. The framework is ar. information-theoretic extension of conventional full-rationality game theory to allow bounded rational agents. The associated optimization algorithm is a game in which agents control the variables of the optimization problem. They do this by jointly minimizing a Lagrangian of (the probability distribution of) their joint state. The updating of the Lagrange parameters in that Lagrangian is a form of automated annealing, one that focuses the multi-agent system on the optimal pure strategy. We present computer experiments for the k-sat constraint satisfaction problem and for unconstrained minimization of NK functions.

  15. Transiting Exoplanet Observations at Grinnell College

    NASA Astrophysics Data System (ADS)

    Sauerhaft, Julia; Slough, P.; Cale, B.; Kempton, E.

    2014-01-01

    Grinnell College, a small liberal arts college in Grinnell, Iowa with 1600 undergraduate students, is home to the Grant O. Gale Observatory. Over the past year, we have successfully detected extrasolar planets using the transit method with our 24-inch Cassegrain reflecting telescope equipped with a CCD camera. With little light pollution and an easily accessible observatory, Grinnell College is an optimal location for transiting exoplanet observations. With the current telescope set-up and CCD camera, we have taken time series data and created image calibration and post-processing programs that detect exoplanet transits at high photometric precision. In the future, we will continue to use these observation and data reduction procedures to conduct transiting exoplanet research. Goals for our research program include performing follow-up observations of transiting exoplanet candidates to confirm their planetary nature, searching for additional exoplanets in known planetary systems using the transit timing detection method, tracking long period transiting planets, and refining properties of exoplanets and their host stars. Ground-based transiting planet science is especially important in the post-Kepler era, and our dedicated mid-sized telescope with plenty of access to dark clear nights provides an ideal resource for a variety of follow up and exoplanet detection efforts.

  16. Optimal Protocols and Optimal Transport in Stochastic Thermodynamics

    NASA Astrophysics Data System (ADS)

    Aurell, Erik; Mejía-Monasterio, Carlos; Muratore-Ginanneschi, Paolo

    2011-06-01

    Thermodynamics of small systems has become an important field of statistical physics. Such systems are driven out of equilibrium by a control, and the question is naturally posed how such a control can be optimized. We show that optimization problems in small system thermodynamics are solved by (deterministic) optimal transport, for which very efficient numerical methods have been developed, and of which there are applications in cosmology, fluid mechanics, logistics, and many other fields. We show, in particular, that minimizing expected heat released or work done during a nonequilibrium transition in finite time is solved by the Burgers equation and mass transport by the Burgers velocity field. Our contribution hence considerably extends the range of solvable optimization problems in small system thermodynamics.

  17. Gas turbine combustor transition

    DOEpatents

    Coslow, Billy Joe; Whidden, Graydon Lane

    1999-01-01

    A method of converting a steam cooled transition to an air cooled transition in a gas turbine having a compressor in fluid communication with a combustor, a turbine section in fluid communication with the combustor, the transition disposed in a combustor shell and having a cooling circuit connecting a steam outlet and a steam inlet and wherein hot gas flows from the combustor through the transition and to the turbine section, includes forming an air outlet in the transition in fluid communication with the cooling circuit and providing for an air inlet in the transition in fluid communication with the cooling circuit.

  18. Gas turbine combustor transition

    DOEpatents

    Coslow, B.J.; Whidden, G.L.

    1999-05-25

    A method is described for converting a steam cooled transition to an air cooled transition in a gas turbine having a compressor in fluid communication with a combustor, a turbine section in fluid communication with the combustor, the transition disposed in a combustor shell and having a cooling circuit connecting a steam outlet and a steam inlet and wherein hot gas flows from the combustor through the transition and to the turbine section, includes forming an air outlet in the transition in fluid communication with the cooling circuit and providing for an air inlet in the transition in fluid communication with the cooling circuit. 7 figs.

  19. Prospective Optimization.

    PubMed

    Sejnowski, Terrence J; Poizner, Howard; Lynch, Gary; Gepshtein, Sergei; Greenspan, Ralph J

    2014-05-01

    Human performance approaches that of an ideal observer and optimal actor in some perceptual and motor tasks. These optimal abilities depend on the capacity of the cerebral cortex to store an immense amount of information and to flexibly make rapid decisions. However, behavior only approaches these limits after a long period of learning while the cerebral cortex interacts with the basal ganglia, an ancient part of the vertebrate brain that is responsible for learning sequences of actions directed toward achieving goals. Progress has been made in understanding the algorithms used by the brain during reinforcement learning, which is an online approximation of dynamic programming. Humans also make plans that depend on past experience by simulating different scenarios, which is called prospective optimization. The same brain structures in the cortex and basal ganglia that are active online during optimal behavior are also active offline during prospective optimization. The emergence of general principles and algorithms for goal-directed behavior has consequences for the development of autonomous devices in engineering applications.

  20. Prospective Optimization

    PubMed Central

    Sejnowski, Terrence J.; Poizner, Howard; Lynch, Gary; Gepshtein, Sergei; Greenspan, Ralph J.

    2014-01-01

    Human performance approaches that of an ideal observer and optimal actor in some perceptual and motor tasks. These optimal abilities depend on the capacity of the cerebral cortex to store an immense amount of information and to flexibly make rapid decisions. However, behavior only approaches these limits after a long period of learning while the cerebral cortex interacts with the basal ganglia, an ancient part of the vertebrate brain that is responsible for learning sequences of actions directed toward achieving goals. Progress has been made in understanding the algorithms used by the brain during reinforcement learning, which is an online approximation of dynamic programming. Humans also make plans that depend on past experience by simulating different scenarios, which is called prospective optimization. The same brain structures in the cortex and basal ganglia that are active online during optimal behavior are also active offline during prospective optimization. The emergence of general principles and algorithms for goal-directed behavior has consequences for the development of autonomous devices in engineering applications. PMID:25328167

  1. Conceptualizing Transitions to Adulthood

    ERIC Educational Resources Information Center

    Wyn, Johanna

    2014-01-01

    This chapter provides an overview of theories of the transition to young adulthood. It sets out the argument for conceptual renewal and discusses some implications of new patterns of transition for adult education.

  2. Transition to Adulthood

    MedlinePlus

    ... fix that! Keep reading… Back to top IDEA’s Definition of Transition Services Any discussion of transition services ... from special education. Back to top Considering the Definition A number of key words in the definition ...

  3. Optimal back-to-front airplane boarding.

    PubMed

    Bachmat, Eitan; Khachaturov, Vassilii; Kuperman, Ran

    2013-06-01

    The problem of finding an optimal back-to-front airplane boarding policy is explored, using a mathematical model that is related to the 1+1 polynuclear growth model with concave boundary conditions and to causal sets in gravity. We study all airplane configurations and boarding group sizes. Optimal boarding policies for various airplane configurations are presented. Detailed calculations are provided along with simulations that support the main conclusions of the theory. We show that the effectiveness of back-to-front policies undergoes a phase transition when passing from lightly congested airplanes to heavily congested airplanes. The phase transition also affects the nature of the optimal or near-optimal policies. Under what we consider to be realistic conditions, optimal back-to-front policies lead to a modest 8-12% improvement in boarding time over random (no policy) boarding, using two boarding groups. Having more than two groups is not effective.

  4. Psychologists and the transition from pediatrics to adult healthcare

    PubMed Central

    Gray, Wendy N.; Monaghan, Maureen C.; Marchak, Jordan Gilleland; Driscoll, Kimberly A.; Hilliard, Marisa E.

    2015-01-01

    Purpose Guidelines for optimal transition call for multidisciplinary teams, including psychologists, to address youth and young adults’ multifactorial needs. This study aimed to characterize psychologists’ roles in and barriers to involvement in transition from pediatric to adult healthcare. Methods Psychologists were invited via professional listservs to complete an online survey about practice settings, roles in transition programming, barriers to involvement, and funding sources. Participants also responded to open-ended questions about their experiences in transition programs. Results One hundred participants responded to the survey. Involvement in transition was reported at multiple levels from individual patient care to institutional transition programming, and 65% reported more than one level of involvement. Direct clinical care (88%), transition-related research (50%) and/or leadership (44%) involvement were reported, with 59% reporting more than one role. Respondents often described advocating for their involvement on transition teams. Various sources of funding were reported, yet 23% reported no funding for their work. Barriers to work in transition were common and included healthcare systems issues such as poor coordination among providers or lack of a clear transition plan within the clinic/institution. Conclusions Psychologists assume numerous roles in the transition of adolescents from pediatric to adult healthcare. With training in healthcare transition-related issues, psychologists are ideally positioned to partner with other health professionals to develop and implement transition programs in multi-disciplinary settings, provided healthcare system barriers can be overcome. PMID:26499856

  5. Transition in Turbines

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The concept of a large disturbance bypass mechanism for the initiation of transition is reviewed and studied. This mechanism, or some manifestation thereof, is suspected to be at work in the boundary layers present in a turbine flow passage. Discussion is presented on four relevant subtopics: (1) the effect of upstream disturbances and wakes on transition; (2) transition prediction models, code development, and verification; (3) transition and turbulence measurement techniques; and (4) the hydrodynamic condition of low Reynolds number boundary layers.

  6. Cosmological phase transitions

    SciTech Connect

    Kolb, E.W. |

    1993-10-01

    If modern ideas about the role of spontaneous symmetry breaking in fundamental physics are correct, then the Universe should have undergone a series of phase transitions early in its history. The study of cosmological phase transitions has become an important aspect of early-Universe cosmology. In this lecture I review some very recent work on three aspects of phase transitions: the electroweak transition, texture, and axions.

  7. Optimal Fluoridation

    PubMed Central

    Lee, John R.

    1975-01-01

    Optimal fluoridation has been defined as that fluoride exposure which confers maximal cariostasis with minimal toxicity and its values have been previously determined to be 0.5 to 1 mg per day for infants and 1 to 1.5 mg per day for an average child. Total fluoride ingestion and urine excretion were studied in Marin County, California, children in 1973 before municipal water fluoridation. Results showed fluoride exposure to be higher than anticipated and fulfilled previously accepted criteria for optimal fluoridation. Present and future water fluoridation plans need to be reevaluated in light of total environmental fluoride exposure. PMID:1130041

  8. Transition: Preschool to Kindergarten

    ERIC Educational Resources Information Center

    Arizona Department of Education, 2007

    2007-01-01

    Transition is movement or change without interruption. It should be a smooth flow from one place or condition to another. While the transition plan for a student receiving special education services is designed to prepare him or her for life after high school, transition can start when a child enters preschool. The second of six distinct stages of…

  9. Transition. Feature Issue.

    ERIC Educational Resources Information Center

    Wallace, Teri, Ed.; And Others

    1992-01-01

    This feature issue of a quarterly bulletin on community integration addresses the topic of transition services for preparing youth with disabilities for adult community living. It contains articles with the following titles and authors: "Transition: The Next Five Years" (David R. Johnson and others); "Transition Policy in the 1990s:…

  10. Optimization by record dynamics

    NASA Astrophysics Data System (ADS)

    Barettin, Daniele; Sibani, Paolo

    2014-03-01

    Large dynamical changes in thermalizing glassy systems are triggered by trajectories crossing record sized barriers, a behavior revealing the presence of a hierarchical structure in configuration space. The observation is here turned into a novel local search optimization algorithm dubbed record dynamics optimization, or RDO. RDO uses the Metropolis rule to accept or reject candidate solutions depending on the value of a parameter akin to the temperature and minimizes the cost function of the problem at hand through cycles where its ‘temperature’ is raised and subsequently decreased in order to expediently generate record high (and low) values of the cost function. Below, RDO is introduced and then tested by searching for the ground state of the Edwards-Anderson spin-glass model, in two and three spatial dimensions. A popular and highly efficient optimization algorithm, parallel tempering (PT), is applied to the same problem as a benchmark. RDO and PT turn out to produce solutions of similar quality for similar numerical effort, but RDO is simpler to program and additionally yields geometrical information on the system’s configuration space which is of interest in many applications. In particular, the effectiveness of RDO strongly indicates the presence of the above mentioned hierarchically organized configuration space, with metastable regions indexed by the cost (or energy) of the transition states connecting them.

  11. The Transition to Secondary Progressive Multiple Sclerosis

    PubMed Central

    Wood, Fiona; Brain, Katherine E.; Edwards, Michelle; Jones, Rhiannon; Wallbank, Rachel; Robertson, Neil P.; Edwards, Adrian

    2016-01-01

    Background: Identifying the transition from relapsing-remitting to secondary progressive multiple sclerosis (SPMS) can be challenging for clinicians. Little previous research has explored how professionals experience working with patients during this specific stage of the disease. We explored the experiences of a group of multidisciplinary professionals who support patients in the transition to SPMS to describe this stage from a professional perspective. Methods: This qualitative semistructured interview study included 11 professionals (medical, nursing, and allied health professionals; specialists and generalists) working with patients with MS in South Wales, United Kingdom. Thematic analysis of the interview data was performed. Results: Two overarching themes were identified: the transition and providing support. The transition theme comprised issues related to recognizing and communicating about SPMS. Uncertainty influenced recognizing the transition and knowing how to discuss it with patients. The providing support theme included descriptions of challenging aspects of patient care, providing support for caregivers, using the multidisciplinary team, and working within service constraints. Providing adequate psychological support and engaging patients with self-management approaches were seen as particularly challenging. Conclusions: Caring for patients in the transition to SPMS generates specific challenges for professionals. Further research on health-care interactions and patients'/professionals' experiences regarding the transition phase may help identify strategies for professional development and learning and how to optimize the patient experience at this difficult stage of disease. PMID:27803641

  12. Gear optimization

    NASA Technical Reports Server (NTRS)

    Vanderplaats, G. N.; Chen, Xiang; Zhang, Ning-Tian

    1988-01-01

    The use of formal numerical optimization methods for the design of gears is investigated. To achieve this, computer codes were developed for the analysis of spur gears and spiral bevel gears. These codes calculate the life, dynamic load, bending strength, surface durability, gear weight and size, and various geometric parameters. It is necessary to calculate all such important responses because they all represent competing requirements in the design process. The codes developed here were written in subroutine form and coupled to the COPES/ADS general purpose optimization program. This code allows the user to define the optimization problem at the time of program execution. Typical design variables include face width, number of teeth and diametral pitch. The user is free to choose any calculated response as the design objective to minimize or maximize and may impose lower and upper bounds on any calculated responses. Typical examples include life maximization with limits on dynamic load, stress, weight, etc. or minimization of weight subject to limits on life, dynamic load, etc. The research codes were written in modular form for easy expansion and so that they could be combined to create a multiple reduction optimization capability in future.

  13. Financing pharmaceuticals in transition economies.

    PubMed

    Kanavos, P

    1999-06-01

    This paper (a) provides a methodological taxonomy of pricing, financing, reimbursement, and cost containment methodologies for pharmaceuticals; (b) analyzes complex agency relationships and the health versus industrial policy tradeoff; (c) pinpoints financing measures to balance safety and effectiveness of medicines and their affordability by publicly funded systems in transition; and (d) highlights viable options for policy-makers for the financing of pharmaceuticals in transition. Three categories of measures and their implications for pharmaceutical policy cost containing are analyzed: supply-side measures, targeting manufacturers, proxy demand-side measures, targeting physicians and pharmacists, and demand-side measures, targeting patients. In pursuing supply side measures, we explore free pricing for pharmaceuticals, direct price controls, cost-plus and cost pricing, average pricing and international price comparisons, profit control, reference pricing, the introduction of a fourth hurdle, positive and negative lists, and other price control measures. The analysis of proxy-demand measures includes budgets for physicians, generic policies, practice guidelines, monitoring the authorizing behavior of physicians, and disease management schemes. Demand-side measures explore the effectiveness of patient co-payments, the impact of allowing products over-the-counter and health promotion programs. Global policies should operate simultaneously on the supply, the proxy demand, and the demand-side. Policy-making needs to have a continuous long-term planning. The importation of policies into transition economy may require extensive and expensive adaptation, and/or lead to sub-optimal policy outcomes.

  14. Transit pricing and performance

    SciTech Connect

    Pickerell, D.H.; Abkowitz, M.; Tozzi, J.; McCord, M.R.; Cheng, L.H.

    1986-01-01

    The 9 papers in the report deal with the following areas: Federal operating assistance for urban mass transit; a decade of experience; transit route characteristics and headway-based reliability control; day-of-week and part-of-month variation in bus ridership; job satisfaction and transit operator recognition programs; results of a survey of muni operators; bus marketing costs: the experience of 18 section 15 reporters from 1981 to 1983; prospects for differential transit pricing in the United States; an initial analysis of total factor productivity for public-transit coordination of transportation resources: the Georgia experience; absenteeism, accidents, and attrition: part-time versus full-time bus drivers.

  15. Biocapacity optimization in regional planning

    NASA Astrophysics Data System (ADS)

    Guo, Jianjun; Yue, Dongxia; Li, Kai; Hui, Cang

    2017-01-01

    Ecological overshoot has been accelerating across the globe. Optimizing biocapacity has become a key to resolve the overshoot of ecological demand in regional sustainable development. However, most literature has focused on reducing ecological footprint but ignores the potential of spatial optimization of biocapacity through regional planning of land use. Here we develop a spatial probability model and present four scenarios for optimizing biocapacity of a river basin in Northwest China. The potential of enhanced biocapacity and its effects on ecological overshoot and water consumption in the region were explored. Two scenarios with no restrictions on croplands and water use reduced the overshoot by 29 to 53%, and another two scenarios which do not allow croplands and water use to increase worsened the overshoot by 11 to 15%. More spatially flexible transition rules of land use led to higher magnitude of change after optimization. However, biocapacity optimization required a large amount of additional water resources, casting considerable pressure on the already water-scarce socio-ecological system. Our results highlight the potential for policy makers to manage/optimize regional land use which addresses ecological overshoot. Investigation on the feasibility of such spatial optimization complies with the forward-looking policies for sustainable development and deserves further attention.

  16. Biocapacity optimization in regional planning

    PubMed Central

    Guo, Jianjun; Yue, Dongxia; Li, Kai; Hui, Cang

    2017-01-01

    Ecological overshoot has been accelerating across the globe. Optimizing biocapacity has become a key to resolve the overshoot of ecological demand in regional sustainable development. However, most literature has focused on reducing ecological footprint but ignores the potential of spatial optimization of biocapacity through regional planning of land use. Here we develop a spatial probability model and present four scenarios for optimizing biocapacity of a river basin in Northwest China. The potential of enhanced biocapacity and its effects on ecological overshoot and water consumption in the region were explored. Two scenarios with no restrictions on croplands and water use reduced the overshoot by 29 to 53%, and another two scenarios which do not allow croplands and water use to increase worsened the overshoot by 11 to 15%. More spatially flexible transition rules of land use led to higher magnitude of change after optimization. However, biocapacity optimization required a large amount of additional water resources, casting considerable pressure on the already water-scarce socio-ecological system. Our results highlight the potential for policy makers to manage/optimize regional land use which addresses ecological overshoot. Investigation on the feasibility of such spatial optimization complies with the forward-looking policies for sustainable development and deserves further attention. PMID:28112224

  17. Optimal protocols for slowly driven quantum systems

    NASA Astrophysics Data System (ADS)

    Zulkowski, Patrick R.; DeWeese, Michael R.

    2015-09-01

    The design of efficient quantum information processing will rely on optimal nonequilibrium transitions of driven quantum systems. Building on a recently developed geometric framework for computing optimal protocols for classical systems driven in finite time, we construct a general framework for optimizing the average information entropy for driven quantum systems. Geodesics on the parameter manifold endowed with a positive semidefinite metric correspond to protocols that minimize the average information entropy production in finite time. We use this framework to explicitly compute the optimal entropy production for a simple two-state quantum system coupled to a heat bath of bosonic oscillators, which has applications to quantum annealing.

  18. Optimal Search and Interdiction Planning

    DTIC Science & Technology

    2014-06-18

    use (United Nations Office on Drugs and Crime , 2012, p. 1) and over 1,500 metric tons of illegal drugs are seized in transit to United States annually...Naval Research, Mathe - matical Optimization and Operations Research Program. References Alpern, S., Gal, S., 2003. The Theory of Search Games and...and Crime , 2012. World Drug Report. United Nations, New York, NY. US Department of Justice, 2014. National Drug Threat Assessment. Retrieved June 3

  19. Enhanced optical transmission at the cutoff transition.

    PubMed

    Laux, E; Genet, C; Ebbesen, T W

    2009-04-27

    The phenomenon of extraordinary transmission in the optical regime for circular hole arrays in optically thick metal films is studied as a function of hole size and depth. In the limit of small holes compared to the depth, the transmission properties follow a waveguide type behavior. By describing the transmission process as resulting from the interference between a resonant and a non-resonant contribution, a transition is clearly revealed through the specific spectral variations of the resonance at a given hole depth. This transition is associated to a change in the attenuation through the hole as its size increases, and corresponds to the optimal condition for surface plasmon excitation.

  20. Transiting Exoplanet Survey Satellite (TESS)

    NASA Astrophysics Data System (ADS)

    Ricker, George R.; Winn, Joshua N.; Vanderspek, Roland; Latham, David W.; Bakos, Gáspár. Á.; Bean, Jacob L.; Berta-Thompson, Zachory K.; Brown, Timothy M.; Buchhave, Lars; Butler, Nathaniel R.; Butler, R. Paul; Chaplin, William J.; Charbonneau, David; Christensen-Dalsgaard, Jørgen; Clampin, Mark; Deming, Drake; Doty, John; De Lee, Nathan; Dressing, Courtney; Dunham, E. W.; Endl, Michael; Fressin, Francois; Ge, Jian; Henning, Thomas; Holman, Matthew J.; Howard, Andrew W.; Ida, Shigeru; Jenkins, Jon; Jernigan, Garrett; Johnson, John A.; Kaltenegger, Lisa; Kawai, Nobuyuki; Kjeldsen, Hans; Laughlin, Gregory; Levine, Alan M.; Lin, Douglas; Lissauer, Jack J.; MacQueen, Phillip; Marcy, Geoffrey; McCullough, P. R.; Morton, Timothy D.; Narita, Norio; Paegert, Martin; Palle, Enric; Pepe, Francesco; Pepper, Joshua; Quirrenbach, Andreas; Rinehart, S. A.; Sasselov, Dimitar; Sato, Bun'ei; Seager, Sara; Sozzetti, Alessandro; Stassun, Keivan G.; Sullivan, Peter; Szentgyorgyi, Andrew; Torres, Guillermo; Udry, Stephane; Villasenor, Joel

    2014-08-01

    The Transiting Exoplanet Survey Satellite (TESS ) will search for planets transiting bright and nearby stars. TESS has been selected by NASA for launch in 2017 as an Astrophysics Explorer mission. The spacecraft will be placed into a highly elliptical 13.7-day orbit around the Earth. During its two-year mission, TESS will employ four wide-field optical CCD cameras to monitor at least 200,000 main-sequence dwarf stars with IC (approximately less than) 13 for temporary drops in brightness caused by planetary transits. Each star will be observed for an interval ranging from one month to one year, depending mainly on the star's ecliptic latitude. The longest observing intervals will be for stars near the ecliptic poles, which are the optimal locations for follow-up observations with the James Webb Space Telescope. Brightness measurements of preselected target stars will be recorded every 2 min, and full frame images will be recorded every 30 min. TESS stars will be 10-100 times brighter than those surveyed by the pioneering Kepler mission. This will make TESS planets easier to characterize with follow-up observations. TESS is expected to find more than a thousand planets smaller than Neptune, including dozens that are comparable in size to the Earth. Public data releases will occur every four months, inviting immediate community-wide efforts to study the new planets. The TESS legacy will be a catalog of the nearest and brightest stars hosting transiting planets, which will endure as highly favorable targets for detailed investigations.

  1. Transiting Exoplanet Survey Satellite (TESS)

    NASA Astrophysics Data System (ADS)

    Ricker, George R.; Winn, Joshua N.; Vanderspek, Roland; Latham, David W.; Bakos, Gáspár Á.; Bean, Jacob L.; Berta-Thompson, Zachory K.; Brown, Timothy M.; Buchhave, Lars; Butler, Nathaniel R.; Butler, R. Paul; Chaplin, William J.; Charbonneau, David; Christensen-Dalsgaard, Jørgen; Clampin, Mark; Deming, Drake; Doty, John; De Lee, Nathan; Dressing, Courtney; Dunham, Edward W.; Endl, Michael; Fressin, Francois; Ge, Jian; Henning, Thomas; Holman, Matthew J.; Howard, Andrew W.; Ida, Shigeru; Jenkins, Jon M.; Jernigan, Garrett; Johnson, John Asher; Kaltenegger, Lisa; Kawai, Nobuyuki; Kjeldsen, Hans; Laughlin, Gregory; Levine, Alan M.; Lin, Douglas; Lissauer, Jack J.; MacQueen, Phillip; Marcy, Geoffrey; McCullough, Peter R.; Morton, Timothy D.; Narita, Norio; Paegert, Martin; Palle, Enric; Pepe, Francesco; Pepper, Joshua; Quirrenbach, Andreas; Rinehart, Stephen A.; Sasselov, Dimitar; Sato, Bun'ei; Seager, Sara; Sozzetti, Alessandro; Stassun, Keivan G.; Sullivan, Peter; Szentgyorgyi, Andrew; Torres, Guillermo; Udry, Stephane; Villasenor, Joel

    2015-01-01

    The Transiting Exoplanet Survey Satellite (TESS) will search for planets transiting bright and nearby stars. TESS has been selected by NASA for launch in 2017 as an Astrophysics Explorer mission. The spacecraft will be placed into a highly elliptical 13.7-day orbit around the Earth. During its 2-year mission, TESS will employ four wide-field optical charge-coupled device cameras to monitor at least 200,000 main-sequence dwarf stars with IC≈4-13 for temporary drops in brightness caused by planetary transits. Each star will be observed for an interval ranging from 1 month to 1 year, depending mainly on the star's ecliptic latitude. The longest observing intervals will be for stars near the ecliptic poles, which are the optimal locations for follow-up observations with the James Webb Space Telescope. Brightness measurements of preselected target stars will be recorded every 2 min, and full frame images will be recorded every 30 min. TESS stars will be 10 to 100 times brighter than those surveyed by the pioneering Kepler mission. This will make TESS planets easier to characterize with follow-up observations. TESS is expected to find more than a thousand planets smaller than Neptune, including dozens that are comparable in size to the Earth. Public data releases will occur every 4 months, inviting immediate community-wide efforts to study the new planets. The TESS legacy will be a catalog of the nearest and brightest stars hosting transiting planets, which will endure as highly favorable targets for detailed investigations.

  2. Multidisciplinary optimization

    SciTech Connect

    Dennis, J.; Lewis, R.M.; Cramer, E.J.; Frank, P.M.; Shubin, G.R.

    1994-12-31

    This talk will use aeroelastic design and reservoir characterization as examples to introduce some approaches to MDO, or Multidisciplinary Optimization. This problem arises especially in engineering design, where it is considered of paramount importance in today`s competitive global business climate. It is interesting to an optimizer because the constraints involve coupled dissimilar systems of parameterized partial differential equations each arising from a different discipline, like structural analysis, computational fluid dynamics, etc. Usually, these constraints are accessible only through pde solvers rather than through algebraic residual calculations as we are used to having. Thus, just finding a multidisciplinary feasible point is a daunting task. Many such problems have discrete variable disciplines, multiple objectives, and other challenging features. After discussing some interesting practical features of the design problem, we will give some standard ways to formulate the problem as well as some novel ways that lend themselves to divide-and-conquer parallelism.

  3. Characterizing the Superconducting-to-Normal Transition in Mo/Au Transition-Edge Sensor Bilayers

    NASA Technical Reports Server (NTRS)

    Smith, Stephen J.; Bandler, Simon R.; Brown, Ari. -D.; Chervenak, Jay A.; Finkbeiner, Fred M.; Iyomoto, Naoko; Kelley, Richard L.; Kilbourne, Caroline A.; Porter, Frederick S.; Sadleir, John E.

    2007-01-01

    We are developing arrays of Mo/Au bilayer transition-edge sensors (TES's) for applications in future X-ray astronomy missions such as NASA's Constellation-X. The physical properties of the superconducting-to-normal transition in our TES bilayers, while often reproducible and characterized, are not well understood. The addition of normal metal features on top of the bilayer are found to change the shape and temperature of the transition, and they typically reduce the unexplained 'excess' noise. In order to understand and potentially optimize the properties of the transition, we have been studying the temperature, widths and current dependence of these transitions. We report on the characterization of devices both deposited on silicon substrates and suspended on thin silicon nitride membranes. This includes key device parameters such as the logarithmic resistance sensitivity with temperature alpha, and the logarithmic resistance sensitivity with current beta, of the phase-transition. We investigate alpha and beta as a function of current, both at fixed and varying bias points in the transition. Using Ginzburg-Landau theory for the current dependence of the superconducting transition temperature, we investigate the relationship between alpha and beta and compare our measured and theoretical estimates.

  4. The periodontal prosthesis mode of transition to an implant-supported dentition.

    PubMed

    Hunt, Peter; Norkin, Frederic; Serrano, Julian

    2006-01-01

    In recent years, implant-supported reconstructions have become a welcome alternative to dentures for those who have lost their natural dentition. While the benefits of the final implant-supported reconstruction may be obvious, the planning and execution of therapy to achieve this result may be bewildering to many dentists. Four main modes of transfer have evolved: an uncontrolled or "haphazard" transition; the traditional "dentures first" mode, an immediate transition, and a staged transition. This article proposes an additional mode of transition called periodontal prosthesis, which has the potential to make the transition process smoother and more predictable while providing optimal retention of alveolar supporting structures and generating optimal esthetics.

  5. Transition Region Models

    NASA Astrophysics Data System (ADS)

    Hansteen, V.; Murdin, P.

    2000-11-01

    The SOLAR TRANSITION REGION comprises the PLASMA between the CHROMOSPHERE and the CORONA. In both of these regions the temperature is fairly uniform. The transition region, by contrast, is believed to be characterized by a very steep temperature rise from a chromospheric temperature of slightly less than 104 K to coronal temperatures on the order of 106 K. The goal of modeling the transition regi...

  6. Transitional Care in Inflammatory Bowel Disease

    PubMed Central

    2011-01-01

    Transitional care is an organized effort to provide pediatric patients with the tools and resources they need to assume personal responsibility for their medical care while facilitating their transfer from a pediatrician to an adult practitioner. Since inflammatory bowel disease (IBD) is usually chronic and up to 25% of IBD patients are diagnosed before the age of 18 years, transitional care is an important consideration for adolescent and young adult patients. The importance of transitional care for chronic diseases that begin in childhood has been recognized in a number of published recommendations. However, most of these recommendations arise from intuitive reasoning, as physicians lack information regarding the need for transitional care, optimal delivery protocols, and the efficacy of transition programs. Even fewer studies have been published regarding transitional care in IBD. Current guidelines stress the importance of providing patients with educational resources to help them develop the skills they need to manage their care as independent adults, introducing the concept of transfer to adult care in advance of the actual transfer, and developing routes of communication to facilitate the transfer from pediatric to adult care providers. Future studies should aim to elucidate which programs are effective and how they should be implemented. PMID:21346849

  7. Energy management during the space shuttle transition.

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.

    1972-01-01

    An approach to calculating optimal, gliding flight paths of the type associated with the space shuttle's transition from entry to cruising flight is presented. Kinetic energy and total energy (per unit weight) replace velocity and time in the dynamic equations, reducing the dimension and complexity of the problem. The capability for treating integral and terminal penalties (as well as Mach number effects) is retained in the numerical optimization; hence, stability and control boundaries can be observed as trajectories to the desired final energy, flight path angle, and range are determined. Numerical results show that the 'jump' to the 'front-side of the L/D curve' need not be made until the end of the transition and that the dynamic model provides a conservative range estimate. Alternatives for real-time trajectory control are discussed.

  8. Energy management during the space shuttle transition

    NASA Technical Reports Server (NTRS)

    Stengel, R. F.

    1972-01-01

    An approach to calculating optimal, gliding flight paths of the type associated with the space shuttle's transition from entry to cruising flight is presented. Kinetic energy and total energy (per unit weight) replace velocity and time in the dynamic equations, reducing the dimension and complexity of the problem. The capability for treating integral and terminal penalties (as well as Mach number effects) is retained in the numerical optimization; hence, stability and control boundaries can be observed as trajectories to the desired final energy, flight path angle, and range are determined. Numerical results show that the jump to the front-side of the L/D curve need not be made until the end of the transition and that the dynamic model provides a conservative range estimate. Alternatives for real time trajectory control are discussed.

  9. [From epidemiological transition to health transition].

    PubMed

    Meslé, F; Vallin, J

    2007-12-01

    The "Epidemiological Transition" concept proposed by Abdel Omran in 1971 was the first theory attempting to explain the extraordinary progess that industrialized countries have achieved in health since the 18th century. Within the broader framework of the demographic transition, an important implication of this concept was that life expectancy in modern societies would converge toward limits determined by the new epidemiological conditions. In the ensuing decades, however the convergence process appears to have stopped as a result of a number of setbacks including the health crisis in Eastern Europe and AIDS in Africa. These setbacks do not fundamentally contradict the theory. A much greater contradiction was the unexpected dramatic decrease in cardiovascular disease that began as early as the 70s and had a major positive impact on life expectancy. Based on the concept of "Health Transition" described by Julio Frenk et al., we propose a complete revision of the health implications of the demographic transition based the idea of successive cycles of divergences/convergences induced by the appearance and generalization of major breakthroughs in health technologies and strategies. Three such cycles can be clearly identified on an international level corresponding to control of infectious then cardiovascular diseases, and perhaps most recently to the initial successes achieved in the field of ageing.

  10. JTF CapMed Warrior Transition Division

    DTIC Science & Technology

    2011-01-25

    Injured Population  To understand the complexity of Warrior Care 2 2011 MHS Conference Warrior Transition Division Mission Provide coordination and...integration of non- medical and medical services to ensure optimal Warrior care throughout the NCR JOA 3 2011 MHS Conference Understanding the Definition of...hostile-related injury or illness requiring long-term care that will require a Medical Evaluation Board (MEB) or Physical Evaluation Board (PEB) to

  11. Coordinated and uncoordinated optimization of networks

    NASA Astrophysics Data System (ADS)

    Brede, Markus

    2010-06-01

    In this paper, we consider spatial networks that realize a balance between an infrastructure cost (the cost of wire needed to connect the network in space) and communication efficiency, measured by average shortest path length. A global optimization procedure yields network topologies in which this balance is optimized. These are compared with network topologies generated by a competitive process in which each node strives to optimize its own cost-communication balance. Three phases are observed in globally optimal configurations for different cost-communication trade offs: (i) regular small worlds, (ii) starlike networks, and (iii) trees with a center of interconnected hubs. In the latter regime, i.e., for very expensive wire, power laws in the link length distributions P(w)∝w-α are found, which can be explained by a hierarchical organization of the networks. In contrast, in the local optimization process the presence of sharp transitions between different network regimes depends on the dimension of the underlying space. Whereas for d=∞ sharp transitions between fully connected networks, regular small worlds, and highly cliquish periphery-core networks are found, for d=1 sharp transitions are absent and the power law behavior in the link length distribution persists over a much wider range of link cost parameters. The measured power law exponents are in agreement with the hypothesis that the locally optimized networks consist of multiple overlapping suboptimal hierarchical trees.

  12. Transitional Division Algorithms.

    ERIC Educational Resources Information Center

    Laing, Robert A.; Meyer, Ruth Ann

    1982-01-01

    A survey of general mathematics students whose teachers were taking an inservice workshop revealed that they had not yet mastered division. More direct introduction of the standard division algorithm is favored in elementary grades, with instruction of transitional processes curtailed. Weaknesses in transitional algorithms appear to outweigh…

  13. Expanding Views on Transition.

    ERIC Educational Resources Information Center

    Repetto, Jeanne B.; Correa, Vivian I.

    1996-01-01

    This position paper proposes an expanded definition of transition, based on common components of early childhood and secondary perspectives. It advocates for a seamless model of transition service delivery for students with disabilities, including program planning, from birth through age 21. The model addresses curriculum, location of services,…

  14. Transition to Living.

    ERIC Educational Resources Information Center

    Repetto, Jeanne B.

    2003-01-01

    Discussion of transition for students with disabilities emphasizes transition skills needed for life beyond work. The importance of assisting students in planning for their life roles as workers, family members, friends, consumers, and community members is discussed. Suggestions are offered to better prepare students for all their life roles by…

  15. Modeling the transition region

    NASA Astrophysics Data System (ADS)

    Singer, Bart A.

    1994-04-01

    The calculation of engineering flows undergoing laminar-turbulent transition presents special problems. Mean-flow quantities obey neither the fully laminar nor the fully turbulent correlations. In addition, local maxima in skin friction, wall temperature, and heat transfer often occur near the end of the transition region. Traditionally, modeling this region has been important for the design of turbine blades, where the transition region is long in relation to the chord length of the blade. More recently, the need for better transition-region models has been recognized by designers of hypersonic vehicles where the high Mach number, the low Reynolds number, and the low-disturbance flight environment emphasize the importance of the transition region. Needless to say, a model that might work well for the transitional flows typically found in gas turbines will not necessarily work well for the external surface of a hypersonic vehicle. In Section 2 of this report, some of the important flow features that control the transition region will be discussed. In Section 3, different approaches to the modeling problem will be summarized and cataloged. Fully turbulent flow models will be discussed in detail in Section 4; models specifically designed for transitional flow, in Section 5; and the evaluation of models, in Section 6.

  16. Seamless Transition for All

    ERIC Educational Resources Information Center

    Test, David W.

    2008-01-01

    Postschool outcomes for students with disabilities have been dismal for quite some time now. Although recent data from the National Longitudinal Transition Study 2 indicate some improvement, students with severe intellectual disabilities continue to transition into segregated employment at unacceptable rates in spite of a multitude of studies,…

  17. Transitioning between Clerkship Directors

    ERIC Educational Resources Information Center

    Soltys, Stephen M.; Pary, Robert J.; Robinson, Stephen W.; Markwell, Stephen J.

    2011-01-01

    Objective: The authors report on succession-planning for mid-level academic positions. Method: The authors describe the process of succession-planning between clerkship directors and the smooth transition resulting in one case. Results: Gradually transitioning allowed a new faculty person to assume the clerkship-director position with minimal…

  18. Transitions in Spousal Caregiving.

    ERIC Educational Resources Information Center

    Burton, Lynda C.; Zdaniuk, Bozena; Schulz, Richard; Jackson, Sharon; Hirsch, Calvin

    2003-01-01

    Describes transitions over 5 years among community-dwelling elderly spouses into and within caregiving roles and associated health outcomes. The trajectory of health outcomes associated with caregiving was generally downward. Those who transitioned to heavy caregiving had more symptoms of depression, and poorer self-reported health and health…

  19. Transitivity of Preferences

    ERIC Educational Resources Information Center

    Regenwetter, Michel; Dana, Jason; Davis-Stober, Clintin P.

    2011-01-01

    Transitivity of preferences is a fundamental principle shared by most major contemporary rational, prescriptive, and descriptive models of decision making. To have transitive preferences, a person, group, or society that prefers choice option "x" to "y" and "y" to "z" must prefer "x" to…

  20. Good Transitions = Great Starts!

    ERIC Educational Resources Information Center

    Our Children: The National PTA Magazine, 2012

    2012-01-01

    The smooth transition of outgoing and incoming board members and officers is of vital importance and can determine the PTA's success for years to come. The transition process is the responsibility of both incoming and outgoing officers and board members. It gives closure to those leaving their positions and allows those coming in to be properly…

  1. Transition Coordinators: Define Yourselves.

    ERIC Educational Resources Information Center

    Asselin, Susan B.; Todd-Allen, Mary; deFur, Sharon

    1998-01-01

    Describes a technique that was used successfully to identify the changing roles and responsibilities of special educators as transition coordinators. The Developing a Curriculum (DACUM) model uses people who are currently working in the occupation to define job responsibilities. The duties of a transition coordinator are identified. (CR)

  2. Matter in transition

    SciTech Connect

    Anderson, Lara B.; Gray, James; Raghuram, Nikhil; Taylor, Washington

    2016-04-13

    In this study, we explore a novel type of transition in certain 6D and 4D quantum field theories, in which the matter content of the theory changes while the gauge group and other parts of the spectrum remain invariant. Such transitions can occur, for example, for SU(6) and SU(7) gauge groups, where matter fields in a three-index antisymmetric representation and the fundamental representation are exchanged in the transition for matter in the two-index antisymmetric representation. These matter transitions are realized by passing through superconformal theories at the transition point. We explore these transitions in dual F-theory and heterotic descriptions, where a number of novel features arise. For example, in the heterotic description the relevant 6D SU(7) theories are described by bundles on K3 surfaces where the geometry of the K3 is constrained in addition to the bundle structure. On the F-theory side, non-standard representations such as the three-index antisymmetric representation of SU(N) require Weierstrass models that cannot be realized from the standard SU(N) Tate form. We also briefly describe some other situations, with groups such as Sp(3), SO(12), and SU(3), where analogous matter transitions can occur between different representations. For SU(3), in particular, we find a matter transition between adjoint matter and matter in the symmetric representation, giving an explicit Weierstrass model for the F-theory description of the symmetric representation that complements another recent analogous construction.

  3. Nonlinear Transient Growth and Boundary Layer Transition

    NASA Technical Reports Server (NTRS)

    Paredes, Pedro; Choudhari, Meelan M.; Li, Fei

    2016-01-01

    Parabolized stability equations (PSE) are used in a variational approach to study the optimal, non-modal disturbance growth in a Mach 3 at plate boundary layer and a Mach 6 circular cone boundary layer. As noted in previous works, the optimal initial disturbances correspond to steady counter-rotating streamwise vortices, which subsequently lead to the formation of streamwise-elongated structures, i.e., streaks, via a lift-up effect. The nonlinear evolution of the linearly optimal stationary perturbations is computed using the nonlinear plane-marching PSE for stationary perturbations. A fully implicit marching technique is used to facilitate the computation of nonlinear streaks with large amplitudes. To assess the effect of the finite-amplitude streaks on transition, the linear form of plane- marching PSE is used to investigate the instability of the boundary layer flow modified by spanwise periodic streaks. The onset of bypass transition is estimated by using an N- factor criterion based on the amplification of the streak instabilities. Results show that, for both flow configurations of interest, streaks of sufficiently large amplitude can lead to significantly earlier onset of transition than that in an unperturbed boundary layer without any streaks.

  4. Modeling and Fitting Exoplanet Transit Light Curves

    NASA Astrophysics Data System (ADS)

    Millholland, Sarah; Ruch, G. T.

    2013-01-01

    We present a numerical model along with an original fitting routine for the analysis of transiting extra-solar planet light curves. Our light curve model is unique in several ways from other available transit models, such as the analytic eclipse formulae of Mandel & Agol (2002) and Giménez (2006), the modified Eclipsing Binary Orbit Program (EBOP) model implemented in Southworth’s JKTEBOP code (Popper & Etzel 1981; Southworth et al. 2004), or the transit model developed as a part of the EXOFAST fitting suite (Eastman et al. in prep.). Our model employs Keplerian orbital dynamics about the system’s center of mass to properly account for stellar wobble and orbital eccentricity, uses a unique analytic solution derived from Kepler’s Second Law to calculate the projected distance between the centers of the star and planet, and calculates the effect of limb darkening using a simple technique that is different from the commonly used eclipse formulae. We have also devised a unique Monte Carlo style optimization routine for fitting the light curve model to observed transits. We demonstrate that, while the effect of stellar wobble on transit light curves is generally small, it becomes significant as the planet to stellar mass ratio increases and the semi-major axes of the orbits decrease. We also illustrate the appreciable effects of orbital ellipticity on the light curve and the necessity of accounting for its impacts for accurate modeling. We show that our simple limb darkening calculations are as accurate as the analytic equations of Mandel & Agol (2002). Although our Monte Carlo fitting algorithm is not as mathematically rigorous as the Markov Chain Monte Carlo based algorithms most often used to determine exoplanetary system parameters, we show that it is straightforward and returns reliable results. Finally, we show that analyses performed with our model and optimization routine compare favorably with exoplanet characterizations published by groups such as the

  5. Communication: Optimal parameters for basin-hopping global optimization based on Tsallis statistics

    SciTech Connect

    Shang, C. Wales, D. J.

    2014-08-21

    A fundamental problem associated with global optimization is the large free energy barrier for the corresponding solid-solid phase transitions for systems with multi-funnel energy landscapes. To address this issue we consider the Tsallis weight instead of the Boltzmann weight to define the acceptance ratio for basin-hopping global optimization. Benchmarks for atomic clusters show that using the optimal Tsallis weight can improve the efficiency by roughly a factor of two. We present a theory that connects the optimal parameters for the Tsallis weighting, and demonstrate that the predictions are verified for each of the test cases.

  6. On the Parameterized Complexity of Some Optimization Problems Related to Multiple-Interval Graphs

    NASA Astrophysics Data System (ADS)

    Jiang, Minghui

    We show that for any constant t ≥ 2, K -Independent Set and K-Dominating Set in t-track interval graphs are W[1]-hard. This settles an open question recently raised by Fellows, Hermelin, Rosamond, and Vialette. We also give an FPT algorithm for K-Clique in t-interval graphs, parameterized by both k and t, with running time max { t O(k), 2 O(klogk) } ·poly(n), where n is the number of vertices in the graph. This slightly improves the previous FPT algorithm by Fellows, Hermelin, Rosamond, and Vialette. Finally, we use the W[1]-hardness of K-Independent Set in t-track interval graphs to obtain the first parameterized intractability result for a recent bioinformatics problem called Maximal Strip Recovery (MSR). We show that MSR-d is W[1]-hard for any constant d ≥ 4 when the parameter is either the total length of the strips, or the total number of adjacencies in the strips, or the number of strips in the optimal solution.

  7. [SIAM conference on optimization

    SciTech Connect

    Not Available

    1992-05-10

    Abstracts are presented of 63 papers on the following topics: large-scale optimization, interior-point methods, algorithms for optimization, problems in control, network optimization methods, and parallel algorithms for optimization problems.

  8. Transition Implementation Guide. Instructor Materials.

    ERIC Educational Resources Information Center

    Boyer-Stephens, Arden, Ed.

    This transition model, called Guiding Education toward Adult Roles for Success (GEARS), provides a comprehensive framework from which transition services and programs can evolve. Three components of transition services are considered: transition partners, the transition process, and adult outcomes. After an introduction, the report's second…

  9. Extrasolar Planetary Transits

    NASA Astrophysics Data System (ADS)

    Cameron, Andrew Collier

    An extrasolar planet will transit the visible hemisphere of its host star if its orbital plane lies sufficiently close to the observer's line of sight. The resulting periodic dips in stellar flux reveal key system parameters, including the density of the host star and, if radial-velocity observations are available, the surface gravitational acceleration of the planet. In this chapter I present the essential methodology for modelling the time-dependent flux variation during a transit, and its use in determining the posterior probability distribution for the physical parameters of the system. Large-scale searches for transiting systems are an efficient way of discovering planets whose bulk densities, and hence compositions, can be accessed if their masses can also be determined. I present algorithms for detrending large ensembles of light curves, for searching for transit-like signals among them. I also discuss methods for identifying diluted stellar eclipsing binaries mimicking planetary transit signals, and validation of transit candidates too faint for radial-velocity follow-up. I review the use of time-resolved spectrophotometry and high-resolution spectroscopy during transits to identify the molecular constituents of exoplanetary atmospheres.

  10. Predictability of critical transitions

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaozhu; Kuehn, Christian; Hallerberg, Sarah

    2015-11-01

    Critical transitions in multistable systems have been discussed as models for a variety of phenomena ranging from the extinctions of species to socioeconomic changes and climate transitions between ice ages and warm ages. From bifurcation theory we can expect certain critical transitions to be preceded by a decreased recovery from external perturbations. The consequences of this critical slowing down have been observed as an increase in variance and autocorrelation prior to the transition. However, especially in the presence of noise, it is not clear whether these changes in observation variables are statistically relevant such that they could be used as indicators for critical transitions. In this contribution we investigate the predictability of critical transitions in conceptual models. We study the quadratic integrate-and-fire model and the van der Pol model under the influence of external noise. We focus especially on the statistical analysis of the success of predictions and the overall predictability of the system. The performance of different indicator variables turns out to be dependent on the specific model under study and the conditions of accessing it. Furthermore, we study the influence of the magnitude of transitions on the predictive performance.

  11. Phase Transitions in Living Neural Networks

    NASA Astrophysics Data System (ADS)

    Williams-Garcia, Rashid Vladimir

    Our nervous systems are composed of intricate webs of interconnected neurons interacting in complex ways. These complex interactions result in a wide range of collective behaviors with implications for features of brain function, e.g., information processing. Under certain conditions, such interactions can drive neural network dynamics towards critical phase transitions, where power-law scaling is conjectured to allow optimal behavior. Recent experimental evidence is consistent with this idea and it seems plausible that healthy neural networks would tend towards optimality. This hypothesis, however, is based on two problematic assumptions, which I describe and for which I present alternatives in this thesis. First, critical transitions may vanish due to the influence of an environment, e.g., a sensory stimulus, and so living neural networks may be incapable of achieving "critical" optimality. I develop a framework known as quasicriticality, in which a relative optimality can be achieved depending on the strength of the environmental influence. Second, the power-law scaling supporting this hypothesis is based on statistical analysis of cascades of activity known as neuronal avalanches, which conflate causal and non-causal activity, thus confounding important dynamical information. In this thesis, I present a new method to unveil causal links, known as causal webs, between neuronal activations, thus allowing for experimental tests of the quasicriticality hypothesis and other practical applications.

  12. Transition nozzle combustion system

    DOEpatents

    Kim, Won-Wook; McMahan, Kevin Weston; Maldonado, Jaime Javier

    2016-11-29

    The present application provides a combustion system for use with a cooling flow. The combustion system may include a head end, an aft end, a transition nozzle extending from the head end to the aft end, and an impingement sleeve surrounding the transition nozzle. The impingement sleeve may define a first cavity in communication with the head end for a first portion of the cooling flow and a second cavity in communication with the aft end for a second portion of the cooling flow. The transition nozzle may include a number of cooling holes thereon in communication with the second portion of the cooling flow.

  13. Holographic magnetic phase transition

    SciTech Connect

    Lifschytz, Gilad; Lippert, Matthew

    2009-09-15

    We study four-dimensional interacting fermions in a strong magnetic field, using the holographic Sakai-Sugimoto model of intersecting D4- and D8-branes in the deconfined, chiral-symmetric parallel phase. We find that as the magnetic field is varied, while staying in the parallel phase, the fermions exhibit a first-order phase transition in which their magnetization jumps discontinuously. Properties of this transition are consistent with a picture in which some of the fermions jump to the lowest Landau level. Similarities to known magnetic phase transitions are discussed.

  14. Momentum injection in tokamak plasmas and transitions to reduced transport.

    PubMed

    Parra, F I; Barnes, M; Highcock, E G; Schekochihin, A A; Cowley, S C

    2011-03-18

    The effect of momentum injection on the temperature gradient in tokamak plasmas is studied. A plausible scenario for transitions to reduced transport regimes is proposed. The transition happens when there is sufficient momentum input so that the velocity shear can suppress or reduce the turbulence. However, it is possible to drive too much velocity shear and rekindle the turbulent transport. The optimal level of momentum injection is determined. The reduction in transport is maximized in the regions of low or zero magnetic shear.

  15. Natural laminar-turbulent transition delay by dielectric barrier discharge

    NASA Astrophysics Data System (ADS)

    Ustinov, Maxim; Kogan, Mikhail; Litvinov, Vladimir; Uspensky, Alexander

    2011-12-01

    The use dielectric barrier discharge for the delay of laminar turbulent transition excited by natural flow disturbances in a quiet wind-tunnel was investigated experimentally. Optimal electrodes location and the operational regime of high-voltage impulse generator provided maximal downstream shift of transition location were found. It was demonstrated that the 10% increase of the laminar part of boundary layer can be obtained using barrier discharge with the cross-flow electrodes. This gives up to 20% friction drag reduction.

  16. Momentum Injection in Tokamak Plasmas and Transitions to Reduced Transport

    SciTech Connect

    Parra, F. I.; Highcock, E. G.; Schekochihin, A. A.; Barnes, M.

    2011-03-18

    The effect of momentum injection on the temperature gradient in tokamak plasmas is studied. A plausible scenario for transitions to reduced transport regimes is proposed. The transition happens when there is sufficient momentum input so that the velocity shear can suppress or reduce the turbulence. However, it is possible to drive too much velocity shear and rekindle the turbulent transport. The optimal level of momentum injection is determined. The reduction in transport is maximized in the regions of low or zero magnetic shear.

  17. Optimal refrigerator

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Hovhannisyan, Karen; Mahler, Guenter

    2010-05-01

    We study a refrigerator model which consists of two n -level systems interacting via a pulsed external field. Each system couples to its own thermal bath at temperatures Th and Tc , respectively (θ≡Tc/Th<1) . The refrigerator functions in two steps: thermally isolated interaction between the systems driven by the external field and isothermal relaxation back to equilibrium. There is a complementarity between the power of heat transfer from the cold bath and the efficiency: the latter nullifies when the former is maximized and vice versa. A reasonable compromise is achieved by optimizing the product of the heat-power and efficiency over the Hamiltonian of the two systems. The efficiency is then found to be bounded from below by ζCA=(1)/(1-θ)-1 (an analog of the Curzon-Ahlborn efficiency), besides being bound from above by the Carnot efficiency ζC=(1)/(1-θ)-1 . The lower bound is reached in the equilibrium limit θ→1 . The Carnot bound is reached (for a finite power and a finite amount of heat transferred per cycle) for lnn≫1 . If the above maximization is constrained by assuming homogeneous energy spectra for both systems, the efficiency is bounded from above by ζCA and converges to it for n≫1 .

  18. Superconductivity in transition metals.

    PubMed

    Slocombe, Daniel R; Kuznetsov, Vladimir L; Grochala, Wojciech; Williams, Robert J P; Edwards, Peter P

    2015-03-13

    A qualitative account of the occurrence and magnitude of superconductivity in the transition metals is presented, with a primary emphasis on elements of the first row. Correlations of the important parameters of the Bardeen-Cooper-Schrieffer theory of superconductivity are highlighted with respect to the number of d-shell electrons per atom of the transition elements. The relation between the systematics of superconductivity in the transition metals and the periodic table high-lights the importance of short-range or chemical bonding on the remarkable natural phenomenon of superconductivity in the chemical elements. A relationship between superconductivity and lattice instability appears naturally as a balance and competition between localized covalent bonding and so-called broken covalency, which favours d-electron delocalization and superconductivity. In this manner, the systematics of superconductivity and various other physical properties of the transition elements are related and unified.

  19. Coping with Transitions.

    ERIC Educational Resources Information Center

    Bendersky, Nora; And Others

    1984-01-01

    Describes a workshop for nine South American students at the Hebrew University of Jerusalem. The two-day session focussed on exploring coping behaviors that could help students adjust to transitions. (JAC)

  20. Transit Timing Variations

    NASA Video Gallery

    The animation shows the difference between planet transit timing of single and multiple planet system. In tightly packed planetary systems, the gravitational pull of the planets among themselves ca...

  1. Oligocyclopentadienyl transition metal complexes

    SciTech Connect

    de Azevedo, Cristina G.; Vollhardt, K. Peter C.

    2002-01-18

    Synthesis, characterization, and reactivity studies of oligocyclopentadienyl transition metal complexes, namely those of fulvalene, tercyclopentadienyl, quatercyclopentadienyl, and pentacyclopentadienyl(cyclopentadienyl) are the subject of this account. Thermal-, photo-, and redox chemistries of homo- and heteropolynuclear complexes are described.

  2. Alternative fuel transit buses

    SciTech Connect

    Motta, R.; Norton, P.; Kelly, K.

    1996-10-01

    The National Renewable Energy Laboratory (NREL) is a U.S. Department of Energy (DOE) national laboratory; this project was funded by DOE. One of NREL`s missions is to objectively evaluate the performance, emissions, and operating costs of alternative fuel vehicles so fleet managers can make informed decisions when purchasing them. Alternative fuels have made greater inroads into the transit bus market than into any other. Each year, the American Public Transit Association (APTA) surveys its members on their inventory and buying plans. The latest APTA data show that about 4% of the 50,000 transit buses in its survey run on an alternative fuel. Furthermore, 1 in 5 of the new transit buses that members have on order are alternative fuel buses. This program was designed to comprehensively and objectively evaluate the alternative fuels in use in the industry.

  3. Palaeontology: turtles in transition.

    PubMed

    Lee, Michael S Y

    2013-06-17

    One of the major remaining gaps in the vertebrate fossil record concerns the origin of turtles. The enigmatic little reptile Eunotosaurus could represent an important transitional form, as it has a rudimentary shell that resembles the turtle carapace.

  4. Urban guideway transit workshop: Proceedings

    SciTech Connect

    Larsen, H. )

    1992-03-01

    On March 20--21, 1991, EPRI sponsored a workshop on urban guideway transit. The purpose of this workshop was to provide utility managers with increased knowledge about urban guideway transit options, public policy regarding transit, and the effect of transit options on utility operations. With this information utilities should be better prepared to make decisions about transit development in their service areas. The workshop also provided EPRI with ideas and information for developing an R D project plan for urban guideway transit.

  5. Bridging the Transition Gap

    DTIC Science & Technology

    2013-05-23

    state and prevent instability agents from establishing 3Nicholas J. Armstrong and Jacqueline Chura-Beaver, Harnessing Post-Conflict Transition: A...reassessing the transition period with a wider range of stakeholder begins with a communal understanding of 118George K. Tanham, War without Guns ...Future.” Military Review (March/April 2006): 11. Armstrong, Nicholas J., and Jacqueline Chura-Beaver. Harnessing Post-Conflict. Carlisle, PA

  6. Quantum Phase Transitions

    DTIC Science & Technology

    2011-05-01

    Park, NC 27709-2211 15. SUBJECT TERMS Quantum Thoery Phase transitions Subir Sachdev Harvard University Office of Sponsored Research 1350...magnetism, and solvable models obtained from string theory. After introducing the basic theory, it moves on to a detailed description of the canonical...students and researchers in condensed matter physics and particle and string theory. Print | Close Quantum Phase Transitions 2nd Edition Subir Sachdev

  7. Matter in transition

    DOE PAGES

    Anderson, Lara B.; Gray, James; Raghuram, Nikhil; ...

    2016-04-13

    In this study, we explore a novel type of transition in certain 6D and 4D quantum field theories, in which the matter content of the theory changes while the gauge group and other parts of the spectrum remain invariant. Such transitions can occur, for example, for SU(6) and SU(7) gauge groups, where matter fields in a three-index antisymmetric representation and the fundamental representation are exchanged in the transition for matter in the two-index antisymmetric representation. These matter transitions are realized by passing through superconformal theories at the transition point. We explore these transitions in dual F-theory and heterotic descriptions, wheremore » a number of novel features arise. For example, in the heterotic description the relevant 6D SU(7) theories are described by bundles on K3 surfaces where the geometry of the K3 is constrained in addition to the bundle structure. On the F-theory side, non-standard representations such as the three-index antisymmetric representation of SU(N) require Weierstrass models that cannot be realized from the standard SU(N) Tate form. We also briefly describe some other situations, with groups such as Sp(3), SO(12), and SU(3), where analogous matter transitions can occur between different representations. For SU(3), in particular, we find a matter transition between adjoint matter and matter in the symmetric representation, giving an explicit Weierstrass model for the F-theory description of the symmetric representation that complements another recent analogous construction.« less

  8. Monotonic convergent optimal control theory with strict limitations on the spectrum of optimized laser fields.

    PubMed

    Gollub, Caroline; Kowalewski, Markus; de Vivie-Riedle, Regina

    2008-08-15

    We present a modified optimal control scheme based on the Krotov method, which allows for strict limitations on the spectrum of the optimized laser fields. A frequency constraint is introduced and derived mathematically correct, without losing monotonic convergence of the algorithm. The method guarantees a close link to learning loop control experiments and is demonstrated for the challenging control of nonresonant Raman transitions, which are used to implement a set of global quantum gates for molecular vibrational qubits.

  9. Frequency domain quantum optimal control under multiple constraints

    NASA Astrophysics Data System (ADS)

    Shu, Chuan-Cun; Ho, Tak-San; Xing, Xi; Rabitz, Herschel

    2016-03-01

    Optimal control of quantum systems with complex constrained external fields is one of the longstanding theoretical and numerical challenges at the frontier of quantum control research. Here, we present a theoretical method that can be utilized to optimize the control fields subject to multiple constraints while guaranteeing monotonic convergence towards desired physical objectives. This optimization method is formulated in the frequency domain in line with the current ultrafast pulse shaping technique, providing the possibility for performing quantum optimal control simulations and experiments in a unified fashion. For illustrations, this method is successfully employed to perform multiple constraint spectral-phase-only optimization for maximizing resonant multiphoton transitions with desired pulses.

  10. Venus Transit 2004

    NASA Astrophysics Data System (ADS)

    Mayo, L. A.; Odenwald, S. F.

    2002-09-01

    December 6th, 1882 was the last transit of the planet Venus across the disk of the sun. It was heralded as an event of immense interest and importance to the astronomical community as well as the public at large. There have been only six such occurrences since Galileo first trained his telescope on the heavens in 1609 and on Venus in 1610 where he concluded that Venus had phases like the moon and appeared to get larger and smaller over time. Many historians consider this the final nail in the coffin of the Ptolemaic, Earth centered solar system. In addition, each transit has provided unique opportunities for discovery such as measurement and refinement of the astronomical unit, calculation of longitudes on the earth, and detection of Venus' atmosphere. The NASA Sun Earth Connection Education Forum in partnership with the Solar System Exploration Forum, DPS, and a number of NASA space missions is developing plans for an international education program centered around the June 8, 2004 Venus transit. The transit will be visible in its entirety from Europe and partially from the East Coast of the United States. We will use a series of robotic observatories including the Telescopes In Education network distributed in latitude to provide observations of the transit that will allow middle and high school students to calculate the A.U. through application of parallax. We will also use Venus transit as a probe of episodes in American history (e.g. 1769: revolutionary era, 1882: post civil war era, and 2004: modern era). Museums and planetariums in the US and Europe will offer real time viewing of the transit and conduct educational programs through professional development seminars, public lectures, and planetarium shows. We are interested in soliciting advice from the research community to coordinate professional research interests with this program.

  11. A flexible transition state searching method for atmospheric reaction systems

    NASA Astrophysics Data System (ADS)

    Lin, Xiao-Xiao; Liu, Yi-Rong; Huang, Teng; Chen, Jiao; Jiang, Shuai; Huang, Wei

    2015-04-01

    The precise and rapid exploration of transition states (TSs) is a major challenge when studying atmospheric reactions due to their complexity. In this work, a Monte Carlo Transition State Search Method (MCTSSM), which integrates Monte Carlo sampling technique with transition state optimization methods using an efficient computer script, has been developed for transition state searches. The efficiency and the potential application in atmospheric reactions of this method have been demonstrated by three types of test suits related to the reactions of atmospheric volatile organic compounds (VOCs): (1) OH addition, (2) OH hydrogen-abstraction, and (3) the other reactive group (e.g. Cl, O3, NO3), especially for the reaction of β-pinene-sCI (stabilized Criegee Intermediates) with water. It was shown that the application of this method with effective restricted parameters has greatly simplified the time-consuming and tedious manual search procedure for transition state (TS) of the bimolecular reaction systems.

  12. A Flexible Transition State Searching Method for Atmospheric Reaction Systems

    SciTech Connect

    Lin, Xiao-Xiao; Liu, Yi-Rong; Huang, Teng; Chen, Jiao; Jiang, Shuai; Huang, Wei

    2015-04-01

    The precise and rapid exploration of transition states (TSs) is a major challenge when studying atmospheric reactions due to their complexity. In this work, a Monte Carlo Transition State Search Method (MCTSSM), which integrates Monte Carlo sampling technique with transition state optimization methods using an efficient computer script, has been developed for transition state searches. The efficiency and the potential application in atmospheric reactions of this method have been demonstrated by three types of test suits related to the reactions of atmospheric volatile organic compounds (VOCs): (1) OH addition, (2) OH hydrogen-abstraction, and (3) the other reactive group (e.g. Cl, O3, NO3), especially for the reaction of β-pinene-sCI (stabilized Criegee Intermediates) with water. It was shown that the application of this method with effective restricted parameters has greatly simplified the time-consuming and tedious manual search procedure for transition state (TS) of the bimolecular reaction systems.

  13. Critical transition in the constrained traveling salesman problem

    NASA Astrophysics Data System (ADS)

    Andrecut, M.; Ali, M. K.

    2001-04-01

    We investigate the finite size scaling of the mean optimal tour length as a function of density of obstacles in a constrained variant of the traveling salesman problem (TSP). The computational experience pointed out a critical transition (at ρc~85%) in the dependence between the excess of the mean optimal tour length over the Held-Karp lower bound and the density of obstacles.

  14. Measuring stellar granulation during planet transits

    NASA Astrophysics Data System (ADS)

    Chiavassa, A.; Caldas, A.; Selsis, F.; Leconte, J.; Von Paris, P.; Bordé, P.; Magic, Z.; Collet, R.; Asplund, M.

    2017-01-01

    Context. Stellar activity and convection-related surface structures might cause bias in planet detection and characterization that use these transits. Surface convection simulations help to quantify the granulation signal. Aims: We used realistic three-dimensional (3D) radiative hydrodynamical (RHD) simulations from the Stagger grid and synthetic images computed with the radiative transfer code Optim3D to model the transits of three prototype planets: a hot Jupiter, a hot Neptune, and a terrestrial planet. Methods: We computed intensity maps from RHD simulations of the Sun and a K-dwarf star at different wavelength bands from optical to far-infrared that cover the range of several ground- and space-based telescopes which observe exoplanet transits. We modeled the transit using synthetic stellar-disk images obtained with a spherical-tile imaging method and emulated the temporal variation of the granulation intensity generating random images covering a granulation time-series of 13.3 h. We measured the contribution of the stellar granulation on the light curves during the planet transit. Results: We identified two types of granulation noise that act simultaneously during the planet transit: (i) the intrinsic change in the granulation pattern with timescale (e.g., 10 min for solar-type stars assumed in this work) is smaller than the usual planet transit ( hours as in our prototype cases); and (ii) the fact that the transiting planet occults isolated regions of the photosphere that differ in local surface brightness as a result of convective-related surface structures. First, we showed that our modeling approach returns granulation timescale fluctuations that are comparable with what has been observed for the Sun. Then, our statistical approach shows that the granulation pattern of solar and K-dwarf-type stars have a non-negligible effect of the light curve depth during the transit, and, consequentially on the determination of the planet transit parameters such as the

  15. Improving Upon String Methods for Transition State Discovery.

    PubMed

    Chaffey-Millar, Hugh; Nikodem, Astrid; Matveev, Alexei V; Krüger, Sven; Rösch, Notker

    2012-02-14

    Transition state discovery via application of string methods has been researched on two fronts. The first front involves development of a new string method, named the Searching String method, while the second one aims at estimating transition states from a discretized reaction path. The Searching String method has been benchmarked against a number of previously existing string methods and the Nudged Elastic Band method. The developed methods have led to a reduction in the number of gradient calls required to optimize a transition state, as compared to existing methods. The Searching String method reported here places new beads on a reaction pathway at the midpoint between existing beads, such that the resolution of the path discretization in the region containing the transition state grows exponentially with the number of beads. This approach leads to favorable convergence behavior and generates more accurate estimates of transition states from which convergence to the final transition states occurs more readily. Several techniques for generating improved estimates of transition states from a converged string or nudged elastic band have been developed and benchmarked on 13 chemical test cases. Optimization approaches for string methods, and pitfalls therein, are discussed.

  16. Multiple Satellite Trajectory Optimization

    DTIC Science & Technology

    2004-12-01

    SOLVING OPTIMAL CONTROL PROBLEMS ........................................5...OPTIMIZATION A. SOLVING OPTIMAL CONTROL PROBLEMS The driving principle used to solve optimal control problems was first formalized by the Soviet...methods and processes of solving optimal control problems , this section will demonstrate how the formulations work as expected. Once coded, the

  17. Noise and Phase Transitions

    NASA Astrophysics Data System (ADS)

    Chen, Zhi; Yu, Clare C.

    2006-03-01

    Noise is present in many physical systems and is often viewed as a nuisance. Yet it can also be a probe of microscopic fluctuations. There have been indications recently that the noise in the resistivity increases in the vicinity of the metal-insulator transition. But what are the characteristics of the noise associated with well-understood first and second order phase transitions? It is well known that critical fluctuations are associated with second order phase transitions, but do these fluctuations lead to enhanced noise? We have addressed these questions using Monte Carlo simulations to study the noise in the 2D Ising model which undergoes a second order phase transition, and in the 5-state Potts model which undergoes a first order phase transition. We monitor these systems as the temperature drops below the critical temperature. At each temperature, after equilibration is established, we obtain the time series of quantities characterizing the properties of the system, i.e., the energy and magnetization per site. We apply different methods, such as the noise power spectrum, the Detrended Fluctuation Analysis (DFA) and the second spectrum of the noise, to analyze the fluctuations in these quantities.

  18. Examining hydrogen transitions.

    SciTech Connect

    Plotkin, S. E.; Energy Systems

    2007-03-01

    This report describes the results of an effort to identify key analytic issues associated with modeling a transition to hydrogen as a fuel for light duty vehicles, and using insights gained from this effort to suggest ways to improve ongoing modeling efforts. The study reported on here examined multiple hydrogen scenarios reported in the literature, identified modeling issues associated with those scenario analyses, and examined three DOE-sponsored hydrogen transition models in the context of those modeling issues. The three hydrogen transition models are HyTrans (contractor: Oak Ridge National Laboratory), MARKAL/DOE* (Brookhaven National Laboratory), and NEMS-H2 (OnLocation, Inc). The goals of these models are (1) to help DOE improve its R&D effort by identifying key technology and other roadblocks to a transition and testing its technical program goals to determine whether they are likely to lead to the market success of hydrogen technologies, (2) to evaluate alternative policies to promote a transition, and (3) to estimate the costs and benefits of alternative pathways to hydrogen development.

  19. RTGs on Transit

    NASA Astrophysics Data System (ADS)

    Dassoulas, John; McNutt, Ralph L.

    2007-01-01

    Transit, the US Navy's Navigation Satellite System was conceived at the Applied Physics Laboratory in 1957 by observing the Doppler shift while tracking Sputnik I. As spacecraft development proceeded there was concern about the ability of batteries to maintain the hermetic seal over a 5-year operational life requirement; therefore, alternate energy sources were investigated. The radioisotope thermoelectric generator (RTG) concept was pursued and resulted in the launch of SNAP 3s, providing partial power on both Transit 4A and 4B. SNAP 9s provided full power on three Transit 5BNs. All launches occurred in the early 1960s. When the U.S. conducted the high altitude nuclear test from Johnson Island, several spacecraft were lost due to artificial enhancement of charged particles in the Earth's magnetosphere resulting in rapid degradation of solar cell power production. This led to the decision to have both an RTG and Solar cell/battery design for Transit power systems; hence, a new RTG design, with a separable heat source and radiative coupling to the thermoelectric elements, was flown on TRIAD. This pioneering effort provided the impetus for future RTGs on interplanetary spacecraft. This paper describes the origin and purpose of the Transit program and provides details on the five satellites in that program that were powered by the first American RTGs used in space. The rationale and some of the challenges inherent in that use are also described.

  20. Variable-cell double-ended surface walking method for fast transition state location of solid phase transitions.

    PubMed

    Zhang, Xiao-Jie; Liu, Zhi-Pan

    2015-10-13

    To identify the low energy pathway for solid-to-solid phase transition has been a great challenge in physics and material science. This work develops a new theoretical method, namely, variable-cell double-ended surface walking (VC-DESW) to locate the transition state (TS) and deduce the pathway in solid phase transition. Inherited from the DESW method ( J. Chem. Theory Comput. 2013 , 9 , 5745 ) for molecular systems, the VC-DESW method implements an efficient mechanism to couple the lattice and atom degrees of freedom. The method features with fast pseudopathway building and accurate TS location for solid phase transition systems without requiring expensive Hessian computation and iterative pathway optimization. A generalized coordinate, consisting of the lattice vectors and the scaled atomic coordinates, is designed for describing the crystal potential energy surface (PES), which is able to capture the anisotropic behavior in phase transition. By comparing with the existing method for solid phase transition in different systems, we show that the VC-DESW method can be much more efficient for finding the TS in crystal phase transition. With the combination of the recently developed unbiased stochastic surface walking pathway sampling method, the VC-DESW is further utilized to resolve the lowest energy pathway of SiO2 α-quartz to quartz-II phase transition from many likely reaction pathways. These new methods provide a powerful platform for understanding and predicting the solid phase transition mechanism and kinetics.

  1. The Concept of Transition System

    ERIC Educational Resources Information Center

    Raffe, David

    2008-01-01

    The term "transition system" describes features of a country's institutional arrangements which shape young people's education-work transitions. It explains why national differences in transition processes and outcomes persist despite apparent pressures for convergence. This paper asks how the concept of transition system has been…

  2. Quantum interface unbinding transitions

    NASA Astrophysics Data System (ADS)

    Jakubczyk, P.

    2012-08-01

    We consider interfacial phenomena accompanying bulk quantum phase transitions in the presence of surface fields. On general grounds we argue that the surface contribution to the system free energy involves a line of singularities characteristic of an interfacial phase transition, occurring below the bulk transition temperature Tc down to T=0. This implies the occurrence of an interfacial quantum critical regime extending into finite temperatures and located within the portion of the phase diagram where the bulk is ordered. Even in situations where the bulk order sets in discontinuously at T=0, the system's behavior at the boundary may be controlled by a divergent length scale if the tricritical temperature is sufficiently low. Relying on an effective interfacial model we compute the surface phase diagram in bulk spatial dimensionality d⩾2 and extract the values of the exponents describing the interfacial singularities in d⩾3.

  3. Electroweak phase transitions

    SciTech Connect

    Anderson, G.W.

    1991-09-16

    An analytic treatment of the one Higgs doublet, electroweak phase transition is given. The phase transition is first order, occurs by the nucleation of thin walled bubbles and completes at a temperature where the order parameter, {l_angle}{phi}{r_angle}{sub T} is significantly smaller than it is when the origin becomes absolutely unstable. The rate of anomalous baryon number violation is an exponentially function of {l_angle}{phi}{r_angle}{sub T}. In very minimal extensions of the standard model it is quite easy to increase {l_angle}{phi}{r_angle}{sub T} so that anomalous baryon number violation is suppressed after completion of the phase transition. Hence baryogenesis at the electroweak phase transition is tenable in minimal of the standard model. In some cases additional phase transitions are possible. For a light Higgs boson, when the top quark mass is sufficiently large, the state where the Higgs field has a vacuum expectation value {l_angle}{phi}{r_angle} = 246 GeV is not the true minimum of the Higgs potential. When this is the case, and when the top quark mass exceeds some critical value, thermal fluctuations in the early universe would have rendered the state {l_angle}{phi}{r_angle} = 246 GeV unstable. The requirement that the state {l_angle}{phi}{r_angle} = 246 GeV is sufficiently long lived constrains the masses of the Higgs boson and the top quark. Finally, we consider whether local phase transitions can be induced by heavy particles which act as seeds for deformations in the scalar field.

  4. Electroweak phase transitions

    SciTech Connect

    Anderson, G.W.

    1991-09-16

    An analytic treatment of the one Higgs doublet, electroweak phase transition is given. The phase transition is first order, occurs by the nucleation of thin walled bubbles and completes at a temperature where the order parameter, {l angle}{phi}{r angle}{sub T} is significantly smaller than it is when the origin becomes absolutely unstable. The rate of anomalous baryon number violation is an exponentially function of {l angle}{phi}{r angle}{sub T}. In very minimal extensions of the standard model it is quite easy to increase {l angle}{phi}{r angle}{sub T} so that anomalous baryon number violation is suppressed after completion of the phase transition. Hence baryogenesis at the electroweak phase transition is tenable in minimal of the standard model. In some cases additional phase transitions are possible. For a light Higgs boson, when the top quark mass is sufficiently large, the state where the Higgs field has a vacuum expectation value {l angle}{phi}{r angle} = 246 GeV is not the true minimum of the Higgs potential. When this is the case, and when the top quark mass exceeds some critical value, thermal fluctuations in the early universe would have rendered the state {l angle}{phi}{r angle} = 246 GeV unstable. The requirement that the state {l angle}{phi}{r angle} = 246 GeV is sufficiently long lived constrains the masses of the Higgs boson and the top quark. Finally, we consider whether local phase transitions can be induced by heavy particles which act as seeds for deformations in the scalar field.

  5. UTM: Universal Transit Modeller

    NASA Astrophysics Data System (ADS)

    Deeg, Hans J.

    2014-12-01

    The Universal Transit Modeller (UTM) is a light-curve simulator for all kinds of transiting or eclipsing configurations between arbitrary numbers of several types of objects, which may be stars, planets, planetary moons, and planetary rings. A separate fitting program, UFIT (Universal Fitter) is part of the UTM distribution and may be used to derive best fits to light-curves for any set of continuously variable parameters. UTM/UFIT is written in IDL code and its source is released in the public domain under the GNU General Public License.

  6. Stellar Variability Effects on Transit Spectroscopy

    NASA Astrophysics Data System (ADS)

    Zellem, Robert Thomas; Swain, Mark R.; Shkolnik, Evgenya; Line, Michael R.; Llama, Joe

    2016-10-01

    Stellar variability caused by surface magnetic activity poses a great challenge to accurately and precisely characterize the atmospheres of transiting exoplanets. We present a preliminary analysis of the effects of unocculted star spots at IR wavelengths on planetary transmission and emission spectra. We will explore how stellar variability changes the derived exoplanet atmospheric parameters inferred through retrievals for a group of exoplanetary hosts stars. Our study includes stars ranging in activity levels from an inactive sun to a very active late-type star, and a range of planetary masses from super-Earths to Jupiters. These effects will be especially important for the high precision measurements (<100 ppm) needed to characterize the atmospheric composition of smaller planets. This work is critical for optimizing the exoplanet observing program of JWST, which will study known habitable zone transiting planets as well as new ones found by TESS orbiting nearby M dwarfs, which are more active than solar-type stars.

  7. Sequence Compaction to Preserve Transition Frequencies

    SciTech Connect

    Pinar, Ali; Liu, C.L.

    2002-12-12

    Simulation-based power estimation is commonly used for its high accuracy despite excessive computation times. Techniques have been proposed to speed it up by compacting an input sequence while preserving its power-consumption characteristics. We propose a novel method to compact a sequence that preserves transition frequencies. We prove the problem is NP-Complete, and propose a graph model to reduce it to that of finding a heaviest weighted trail on a directed graph, along with a heuristic utilizing this model. We also propose using multiple sequences for better accuracy with even shorter sequences. Experiments showed that power dissipation can be estimated with an error of only 2.3 percent, while simulation times are reduced by 10. Proposed methods effectively preserve transition frequencies and generated solutions that are very close to an optimal. Experiments also showed that multiple sequences granted more accurate results with even shorter sequences.

  8. Variational transition state theory

    SciTech Connect

    Truhlar, D.G.

    1993-12-01

    This research program involves the development of variational transition state theory (VTST) and semiclassical tunneling methods for the calculation of gas-phase reaction rates and selected applications. The applications are selected for their fundamental interest and/or their relevance to combustion.

  9. Youth Policy in Transition.

    ERIC Educational Resources Information Center

    Timpane, Michael; And Others

    A study team was commissioned to critically review three independent reports on youth and schooling: "Youth: Transition to Adulthood"; "The Education of Adolescents"; and "The Reform of Secondary Education." The study team examined the reports in light of the most recent available social science evidence. The three reports, presenting similar…

  10. Singing Smoothes Classroom Transitions

    ERIC Educational Resources Information Center

    Mathews, Sarah E.

    2012-01-01

    Just as humming a merry tune helped Snow White and her furry animal friends to quickly clean a filthy cottage in the movie "Snow White and the Seven Dwarfs" (Disney & Cottrell, 1937), singing can be an effective way to help keep young children fully engaged during classroom transitions. The purposes of this article are to: (1) consider why…

  11. A Transiting Jupiter Analog

    NASA Astrophysics Data System (ADS)

    Kipping, D. M.; Torres, G.; Henze, C.; Teachey, A.; Isaacson, H.; Petigura, E.; Marcy, G. W.; Buchhave, L. A.; Chen, J.; Bryson, S. T.; Sandford, E.

    2016-04-01

    Decadal-long radial velocity surveys have recently started to discover analogs to the most influential planet of our solar system, Jupiter. Detecting and characterizing these worlds is expected to shape our understanding of our uniqueness in the cosmos. Despite the great successes of recent transit surveys, Jupiter analogs represent a terra incognita, owing to the strong intrinsic bias of this method against long orbital periods. We here report on the first validated transiting Jupiter analog, Kepler-167e (KOI-490.02), discovered using Kepler archival photometry orbiting the K4-dwarf KIC-3239945. With a radius of (0.91+/- 0.02) {R}{{J}}, a low orbital eccentricity ({0.06}-0.04+0.10), and an equilibrium temperature of (131+/- 3) K, Kepler-167e bears many of the basic hallmarks of Jupiter. Kepler-167e is accompanied by three Super-Earths on compact orbits, which we also validate, leaving a large cavity of transiting worlds around the habitable-zone. With two transits and continuous photometric coverage, we are able to uniquely and precisely measure the orbital period of this post snow-line planet (1071.2323 ± 0.0006d), paving the way for follow-up of this K = 11.8 mag target.

  12. String mediated phase transitions

    NASA Technical Reports Server (NTRS)

    Copeland, ED; Haws, D.; Rivers, R.; Holbraad, S.

    1988-01-01

    It is demonstrated from first principles how the existence of string-like structures can cause a system to undergo a phase transition. In particular, the role of topologically stable cosmic string in the restoration of spontaneously broken symmetries is emphasized. How the thermodynamic properties of strings alter when stiffness and nearest neighbor string-string interactions are included is discussed.

  13. exorings: Exoring Transit Properties

    NASA Astrophysics Data System (ADS)

    Zuluaga, Jorge I.; Kipping, David M.; Sucerquia, Mario; Alvarado, Jaime A.

    2017-03-01

    Exorings is suitable for surveying entire catalogs of transiting planet candidates for exoring candidates, providing a subset of objects worthy of more detailed light curve analysis. Moreover, it is highly suited for uncovering evidence of a population of ringed planets by comparing the radius anomaly and PR-effects in ensemble studies.

  14. A Survey Transition Course

    ERIC Educational Resources Information Center

    Johnston, William; McAllister, Alex M.

    2012-01-01

    Successful outcomes for a "Transition Course in Mathematics" have resulted from two unique design features. The first is to run the course as a "survey course" in mathematics, introducing sophomore-level students to a broad set of mathematical fields. In this single mathematics course, undergraduates benefit from an introduction of proof…

  15. Tips for Transition

    ERIC Educational Resources Information Center

    Kellems, Ryan O.; Morningstar, Mary E.

    2010-01-01

    The Individuals With Disabilities Education Improvement Act of 2004 (IDEA) states that transition planning should begin at the earliest age appropriate and no later than age 16. IDEA requires schools to make collaborative efforts to provide students access to an array of postschool activities including integrated employment, postsecondary…

  16. Families in Transition.

    ERIC Educational Resources Information Center

    Britton, Patti O., Ed.; McGee, Michael, Ed.

    1987-01-01

    This issue of "Emphasis" deals with families in transition, providing some model programs for the new family and some historical perspectives on how families have developed over time. Articles include: (1) "Nostalgia on the Right" (Nancy Theriot); (2) "Heart to Heart" (Nancy Harrington-MacLennan); (3) "The Media Get the Message" (Janet Alyn); (4)…

  17. The TRANSITION Program.

    ERIC Educational Resources Information Center

    Office of the Assistant Secretary of Defense for Manpower and Reserve Affairs (DOD), Washington, DC.

    Operated on a voluntary, decentralized basis at 215 military bases (58 overseas), the TRANSITION Program is designed to provide maximum guidance and training or educational opportunities for servicemen during their last six months of duty to prepare them for productive reentry into civilian life. Public and private placement services are also…

  18. Selected Readings in Transition.

    ERIC Educational Resources Information Center

    Harnisch, Delwyn L.; And Others

    This collection of readings covers critical issues related to transition of youth with disabilities from school to post-school experiences. The first paper, titled "'Cognitive Return' of Schooling for Students with Disabilities: Preliminary Findings from 'High School and Beyond'" by Delwyn L. Harnisch and Ian A. G. Wilkinson, applies…

  19. Learning for Life Transitions

    ERIC Educational Resources Information Center

    Varmecky, Jane Hyde

    2012-01-01

    Many adults return to formal learning situations to pursue lifelong learning goals because their lives are in transition from dealing with real-life problems such as divorce and re-marriage. The purpose of this study was to describe what couples learned that contributed to the success of their subsequent marriages and how they learned it. The…

  20. Modeling of transitional flows

    NASA Technical Reports Server (NTRS)

    Lund, Thomas S.

    1988-01-01

    An effort directed at developing improved transitional models was initiated. The focus of this work was concentrated on the critical assessment of a popular existing transitional model developed by McDonald and Fish in 1972. The objective of this effort was to identify the shortcomings of the McDonald-Fish model and to use the insights gained to suggest modifications or alterations of the basic model. In order to evaluate the transitional model, a compressible boundary layer code was required. Accordingly, a two-dimensional compressible boundary layer code was developed. The program was based on a three-point fully implicit finite difference algorithm where the equations were solved in an uncoupled manner with second order extrapolation used to evaluate the non-linear coefficients. Iteration was offered as an option if the extrapolation error could not be tolerated. The differencing scheme was arranged to be second order in both spatial directions on an arbitrarily stretched mesh. A variety of boundary condition options were implemented including specification of an external pressure gradient, specification of a wall temperature distribution, and specification of an external temperature distribution. Overall the results of the initial phase of this work indicate that the McDonald-Fish model does a poor job at predicting the details of the turbulent flow structure during the transition region.

  1. Families in Transition .

    ERIC Educational Resources Information Center

    Bundy, Michael L., Ed.; Gumaer, James, Ed.

    1984-01-01

    Focuses on disrupted families and the role of the school counselor in helping children adjust. Describes characteristics of healthy families, and discusses the transition to the blended family, effects of divorce groups on children's classroom behavior, counseling children in stepfamilies, single-parent families, and parenting strengths of single…

  2. Immigration and Adult Transitions

    ERIC Educational Resources Information Center

    Rumbaut, Ruben G.; Komaie, Golnaz

    2010-01-01

    Almost 30 percent of the more than 68 million young adults aged eighteen to thirty-four in the United States today are either foreign born or of foreign parentage. As these newcomers make their transitions to adulthood, say Ruben Rumbaut and Golnaz Komaie, they differ significantly not only from one another but also from their native-parentage…

  3. Nursing Role Transition Preceptorship

    ERIC Educational Resources Information Center

    Batory, Susan M.

    2014-01-01

    The preceptorship clinical experience in a practical nursing (PN) program at a Midwestern community college is considered crucial to the PN students' transition from novice nurse to professional nurse. However, no research has been available to determine whether the preceptorship clinical accomplishes its purpose. A case study was conducted to…

  4. Administrative Theory in Transition.

    ERIC Educational Resources Information Center

    Griffiths, Daniel E.

    This monograph analyzes transition in educational administrative theory. A brief introductory section describes the theoretical movement, the substance and repercussions of Thomas Greenfield's critique of educational administrative theory in 1974, and emerging qualitative approaches. Seven readings, all written by the volume's author, view…

  5. Transition at hypersonic speeds

    NASA Technical Reports Server (NTRS)

    Morkovin, Mark V.

    1987-01-01

    Certain conjectures on the physics of instabilities in high-speed flows are discussed and the state of knowledge of hypersonic transition summarized. The case is made for an unpressured systematic research program in this area consisting of controlled microscopic experiments, theory, and numerical simulations.

  6. Transition and the Education of the New South African Citizen

    ERIC Educational Resources Information Center

    Hammett, Daniel; Staeheli, Lynn

    2013-01-01

    South Africa's democratic transition was a time of optimism, with immense hopes pinned on the youth who would be educated to see themselves as equal citizens. It was also a time of pragmatic decision making, not least in the education sector, which would shape the future of the country. Negotiating the imperatives of redress, development, and…

  7. Topic Transition in Educational Videos Using Visually Salient Words

    ERIC Educational Resources Information Center

    Gandhi, Ankit; Biswas, Arijit; Deshmukh, Om

    2015-01-01

    In this paper, we propose a visual saliency algorithm for automatically finding the topic transition points in an educational video. First, we propose a method for assigning a saliency score to each word extracted from an educational video. We design several mid-level features that are indicative of visual saliency. The optimal feature combination…

  8. Adaptation and optimization of biological transport networks.

    PubMed

    Hu, Dan; Cai, David

    2013-09-27

    It has been hypothesized that topological structures of biological transport networks are consequences of energy optimization. Motivated by experimental observation, we propose that adaptation dynamics may underlie this optimization. In contrast to the global nature of optimization, our adaptation dynamics responds only to local information and can naturally incorporate fluctuations in flow distributions. The adaptation dynamics minimizes the global energy consumption to produce optimal networks, which may possess hierarchical loop structures in the presence of strong fluctuations in flow distribution. We further show that there may exist a new phase transition as there is a critical open probability of sinks, above which there are only trees for network structures whereas below which loops begin to emerge.

  9. Transit of Extrasolar Planets

    NASA Technical Reports Server (NTRS)

    Doyle, Laurance R.

    1998-01-01

    During the past five years we have pursued the detection of extrasolar planets by the photometric transit method, i.e. the detection of a planet by watching for a drop in the brightness of the light as it crosses in front of a star. The planetary orbit must cross the line-of-sight and so most systems will not be lined up for such a transit to ever occur. However, we have looked at eclipsing binary systems which are already edge-on. Such systems must be very small in size as this makes the differential light change due to a transit much greater for a given planet size (the brightness difference will be proportional to the area of the transiting planet to the disc area of the star). Also, the planet forming region should be closer to the star as small stars are generally less luminous (that is, if the same thermal regime for planet formation applies as in the solar system). This led to studies of the habitable zone around other stars, as well. Finally, we discovered that our data could be used to detect giant planets without transits as we had been carefully timing the eclipses of the stars (using a GPS antenna for time) and this will drift by being offset by any giant planets orbiting around the system, as well. The best summary of our work may be to just summarize the 21 refereed papers produced during the time of this grant. This will be done is chronological order and in each section separately.

  10. Quantum Transition State Theory

    NASA Astrophysics Data System (ADS)

    Waalkens, Holger

    2009-03-01

    The main idea of Wigner's transition state theory (TST) is to compute reaction rates from the flux through a dividing surface placed between reactants and products. In order not to overestimate the rate the dividing surface needs to have the no- recrossing property, i.e. reactive trajectories cross the dividing surface exactly once, and nonreactive trajectories do not cross it at all. The long standing problem of how to construct such a diving surface for multi-degree-of-freedom systems was solved only recently using ideas from dynamical systems theory. Here a normal form allows for a local decoupling of the classical dynamics which leads to the explicit construction of the phase space structures that govern the reaction dynamics through transition states. The dividing surface is spanned by a normally hyperbolic manifold which is the mathematical manifestation of the transition state as an unstable invariant subsystem of one degree of freedom less than the full system. The mere existence of a quantum version of TST is discussed controversially in the literature. The key isssue is the presence of quantum mechanical tunneling which prohibits the existence of a local theory analogous to the classical case. Various approaches have been devloped to overcome this problem by propagating quantum wavefunctions through the transition state region. These approaches have in common that they are computationally very expensive which seriously limits their applicability. In contrast the approach by Roman Schubert, Stephen Wiggins and myself is local in nature. A quantum normal form allows us to locally decouple the quantum dynamics to any desired order in Planck's constant. This yields not only the location of the scattering and resonance wavefunctions relative to the classical phase space structures, but also leads to very efficient algorithms to compute cumulative reaction probabilities and Gamov-Siegert resonances which are the quantum imprints of the transition state.

  11. Electrothermal design aspects of transitioning solid armatures

    NASA Astrophysics Data System (ADS)

    Schoolderman, A. J.; de Zeeuw, W. A.; Koops, M.

    1993-01-01

    To optimize erosion-free rail accelerator launch of solid brush armatures, a 2D model and an analytical model are used to study the temperature distribution, the coefficient of friction and the transitioning behavior of U-shaped solid armatures made of Cu, Al, Mo, and Ti during electromagnetic launch. In order to experimentally verify the insights gained from these theoretical studies, recently developed diagnostics are applied. The growth potential of solid armatures for weapons applications is highlighted by considering such materials as Ti and Mo.

  12. Control of rare events in reaction and population systems by deterministically imposed transitions.

    PubMed

    Khasin, M; Dykman, M I

    2011-03-01

    We consider control of reaction and population systems by imposing transitions between states with different numbers of particles or individuals. The transitions take place at predetermined instants of time. Even where they are significantly less frequent than spontaneous transitions, they can exponentially strongly modify the rates of rare events, including switching between metastable states or population extinction. We also study optimal control of rare events. Specifically, we are interested in the optimal control of disease extinction for a limited vaccine supply. A comparison is made with control of rare events by modulating the rates of elementary transitions rather than imposing transitions deterministically. It is found that, unexpectedly, for the same mean control parameters, controlling the transitions rates can be more efficient.

  13. Improving care transitions: current practice and future opportunities for pharmacists.

    PubMed

    Hume, Anne L; Kirwin, Jennifer; Bieber, Heather L; Couchenour, Rachel L; Hall, Deanne L; Kennedy, Amy K; LaPointe, Nancy M Allen; Burkhardt, Crystal D O; Schilli, Kathleen; Seaton, Terry; Trujillo, Jennifer; Wiggins, Barbara

    2012-11-01

    During the past decade, patient safety issues during care transitions have gained greater attention at both the local and national level. Readmission rates to U.S. hospitals are high, often because of poor care transitions. Serious adverse drug events (ADEs) caused by an incomplete understanding of changes in complex drug regimens can be an important factor contributing to readmission rates. This paper describes the roles and responsibilities of pharmacists in ensuring optimal outcomes from drug therapy during care transitions. Barriers to effective care transitions, including inadequate communication, poor care coordination, and the lack of one clinician ultimately responsible for these transitions, are discussed. This paper also identifies specific patient populations at high risk of ADEs during care transitions. Several national initiatives and newer care transition models are discussed, including multi- and interdisciplinary programs with pharmacists as key members. Among their potential roles, pharmacists should participate on medical rounds where available, perform medication reconciliation and admission drug histories, apply their knowledge of drug therapy to anticipate and resolve problems during transitions, communicate changes in drug regimens between providers and care settings, assess the appropriateness and patient understanding of drug regimens, promote adherence, and assess health literacy. In addition, this paper identifies barriers and ongoing challenges limiting greater involvement of pharmacists from different practice settings during care transitions. Professional degree programs and residency training programs should increase their emphasis on pharmacists' roles, especially as part of interdisciplinary teams, in improving patient safety during care transitions in diverse practice settings. This paper also recommends that Accreditation Council for Pharmacy Education (ACPE) standards include specific language regarding the exposure of students to

  14. Alternative fuel transit buses: The Pierce Transit Success Story

    SciTech Connect

    1996-10-01

    The Pierce transit program for operating mass transit buses on compressed natural gas (CNG) is described. Cost, reliability, fuel efficiency, emission of combustion products, and future trends are discussed.

  15. "Views of Professionals on Aims and Outcomes of Transition for Young People with Learning Disabilities"

    ERIC Educational Resources Information Center

    Kaehne, Axel; Beyer, Stephen

    2009-01-01

    The paper reports the findings of a study of professionals in strategic and operational positions who were involved in transition planning for young people with learning disabilities. Respondents were asked to comment on what they regarded as the optimal aim and outcome of transition from school to post-school placements. The results illustrate…

  16. A Qualitative Analysis of an Advanced Practice Nurse-Directed Transitional Care Model Intervention

    ERIC Educational Resources Information Center

    Bradway, Christine; Trotta, Rebecca; Bixby, M. Brian; McPartland, Ellen; Wollman, M. Catherine; Kapustka, Heidi; McCauley, Kathleen; Naylor, Mary D.

    2012-01-01

    Purpose: The purpose of this study was to describe barriers and facilitators to implementing a transitional care intervention for cognitively impaired older adults and their caregivers lead by advanced practice nurses (APNs). Design and Methods: APNs implemented an evidence-based protocol to optimize transitions from hospital to home. An…

  17. Radiation Shielding Optimization on Mars

    NASA Technical Reports Server (NTRS)

    Slaba, Tony C.; Mertens, Chris J.; Blattnig, Steve R.

    2013-01-01

    Future space missions to Mars will require radiation shielding to be optimized for deep space transit and an extended stay on the surface. In deep space, increased shielding levels and material optimization will reduce the exposure from most solar particle events (SPE) but are less effective at shielding against galactic cosmic rays (GCR). On the surface, the shielding provided by the Martian atmosphere greatly reduces the exposure from most SPE, and long-term GCR exposure is a primary concern. Previous work has shown that in deep space, additional shielding of common materials such as aluminum or polyethylene does not significantly reduce the GCR exposure. In this work, it is shown that on the Martian surface, almost any amount of aluminum shielding increases exposure levels for humans. The increased exposure levels are attributed to neutron production in the shield and Martian regolith as well as the electromagnetic cascade induced in the Martian atmosphere. This result is significant for optimization of vehicle and shield designs intended for the surface of Mars.

  18. Optimal control of overdamped systems

    NASA Astrophysics Data System (ADS)

    Zulkowski, Patrick R.; DeWeese, Michael R.

    2015-09-01

    Nonequilibrium physics encompasses a broad range of natural and synthetic small-scale systems. Optimizing transitions of such systems will be crucial for the development of nanoscale technologies and may reveal the physical principles underlying biological processes at the molecular level. Recent work has demonstrated that when a thermodynamic system is driven away from equilibrium then the space of controllable parameters has a Riemannian geometry induced by a generalized inverse diffusion tensor. We derive a simple, compact expression for the inverse diffusion tensor that depends solely on equilibrium information for a broad class of potentials. We use this formula to compute the minimal dissipation for two model systems relevant to small-scale information processing and biological molecular motors. In the first model, we optimally erase a single classical bit of information modeled by an overdamped particle in a smooth double-well potential. In the second model, we find the minimal dissipation of a simple molecular motor model coupled to an optical trap. In both models, we find that the minimal dissipation for the optimal protocol of duration τ is proportional to 1 /τ , as expected, though the dissipation for the erasure model takes a different form than what we found previously for a similar system.

  19. Optimization of composite structures

    NASA Technical Reports Server (NTRS)

    Stroud, W. J.

    1982-01-01

    Structural optimization is introduced and examples which illustrate potential problems associated with optimized structures are presented. Optimized structures may have very low load carrying ability for an off design condition. They tend to have multiple modes of failure occurring simultaneously and can, therefore, be sensitive to imperfections. Because composite materials provide more design variables than do metals, they allow for more refined tailoring and more extensive optimization. As a result, optimized composite structures can be especially susceptible to these problems.

  20. Transitions: exploring the frontier.

    PubMed

    Corless, Inge B

    End-of-life experiences go by various terms, including near-death experiences (NDEs), death bed visions, death bed phenomena, death bed coincidences, and nearing death awareness. Death bed escorts is the term applied to the vision of deceased family members or friends who inform the dying person that they will be accompanied in the transition from life. In this article, I examine the subject of NDEs and death bed escorts, starting with the rich body of work provided by Robert and Beatrice Kastenbaum. A subject of some interest to Robert Kastenbaum, he explored this frontier in his many writings on dying, death, and bereavement. Ever the pioneer and having made the ultimate transition, he may yet be exploring new frontiers.

  1. Emergence and Phase Transitions

    NASA Astrophysics Data System (ADS)

    Sikkema, Arnold

    2006-05-01

    Phase transitions are well defined in physics through concepts such as spontaneous symmetry breaking, order parameter, entropy, and critical exponents. But emergence --- also exhibiting whole-part relations (such as top-down influence), unpredictability, and insensitivity to microscopic detail --- is a loosely-defined concept being used in many disciplines, particularly in psychology, biology, philosophy, as well as in physics[1,2]. I will review the concepts of emergence as used in the various fields and consider the extent to which the methods of phase transitions can clarify the usefulness of the concept of emergence both within the discipline of physics and beyond.1. Robert B. Laughlin, A Different Universe: Reinventing Physics from the Bottom Down (New York: Basic Books, 2005). 2. George F.R. Ellis, ``Physics and the Real World'', Physics Today, vol. 58, no. 7 (July 2005) pp. 49-54.

  2. The Need for Transition

    DTIC Science & Technology

    2013-05-01

    assumptions. According to the original plan and assumptions, the Iraqi Police forces, which intelligence sources asserted were going to capitulate and...higher. This was all a result of failed assumptions in the prewar planning. Colonel Gregory Gardner , a member of the Joint Staff and then also on the...Institute (PKSOI) held a two day conference with multiple forces and international partners involved just to try and define transition. Each one of these

  3. Stimulated coherent transition radiation

    SciTech Connect

    Hung-chi Lihn

    1996-03-01

    Coherent radiation emitted from a relativistic electron bunch consists of wavelengths longer than or comparable to the bunch length. The intensity of this radiation out-numbers that of its incoherent counterpart, which extends to wavelengths shorter than the bunch length, by a factor equal to the number of electrons in the bunch. In typical accelerators, this factor is about 8 to 11 orders of magnitude. The spectrum of the coherent radiation is determined by the Fourier transform of the electron bunch distribution and, therefore, contains information of the bunch distribution. Coherent transition radiation emitted from subpicosecond electron bunches at the Stanford SUNSHINE facility is observed in the far-infrared regime through a room-temperature pyroelectric bolometer and characterized through the electron bunch-length study. To measure the bunch length, a new frequency-resolved subpicosecond bunch-length measuring system is developed. This system uses a far-infrared Michelson interferometer to measure the spectrum of coherent transition radiation through optical autocorrelation with resolution far better than existing time-resolved methods. Hence, the radiation spectrum and the bunch length are deduced from the autocorrelation measurement. To study the stimulation of coherent transition radiation, a special cavity named BRAICER is invented. Far-infrared light pulses of coherent transition radiation emitted from electron bunches are delayed and circulated in the cavity to coincide with subsequent incoming electron bunches. This coincidence of light pulses with electron bunches enables the light to do work on electrons, and thus stimulates more radiated energy. The possibilities of extending the bunch-length measuring system to measure the three-dimensional bunch distribution and making the BRAICER cavity a broadband, high-intensity, coherent, far-infrared light source are also discussed.

  4. Transition Region Flows

    NASA Astrophysics Data System (ADS)

    Brekke, P.; Murdin, P.

    2000-11-01

    Ultraviolet emission lines emitted from the SOLAR TRANSITION REGION are often shifted from their expected rest wavelengths. Shifts of spectral lines are due to the so-called DOPPLER EFFECT, where the source of emission is moving either away from or towards the observer, causing a change in the apparent wavelength. The shifted emission lines are most often interpreted as a flow of plasma along ...

  5. The Myths of Mass Transit.

    ERIC Educational Resources Information Center

    Burke, Catherine G.

    1982-01-01

    Criticizes eight commonly held notions about the value of mass transit systems in public transportation programs. Alternative approaches for improving the quality and quantity of urban transit systems are discussed. (AM)

  6. Psychological Aspects of Transitive Verbs

    ERIC Educational Resources Information Center

    Polzella, Donald J.; Rohrman, Nicholas L.

    1970-01-01

    The experiments reported here confirmed the findings of earlier researchers that transitive verbs are more difficult to recall than intransitive ones and furthermore established a close relationship between transitive verbs and nouns. Implications for linguistic theory are discussed. (FB)

  7. Youths Transitioning as Adult Learners

    ERIC Educational Resources Information Center

    Davis, C. Amelia

    2014-01-01

    This chapter considers how transitions to adulthood have been historically represented and presents alternative ways of thinking about transitions to adulthood through the context of adult basic education programs.

  8. Transition mixing study

    NASA Technical Reports Server (NTRS)

    Reynolds, R.; White, C.

    1986-01-01

    A computer model capable of analyzing the flow field in the transition liner of small gas turbine engines is developed. A FORTRAN code has been assembled from existing codes and physical submodels and used to predict the flow in several test geometries which contain characteristics similar to transition liners, and for which experimental data was available. Comparisons between the predictions and measurements indicate that the code produces qualitative results but that the turbulence models, both K-E and algebraic Reynolds Stress, underestimate the cross-stream diffusion. The code has also been used to perform a numerical experiment to examine the effect of a variety of parameters on the mixing process in transition liners. Comparisons illustrate that geometries with significant curvature show a drift of the jet trajectory toward the convex wall and weaker wake region vortices and decreased penetration for jets located on the convex wall of the liner, when compared to jets located on concave walls. Also shown were the approximate equivalency of angled slots and round holes and a technique by which jet mixing correlations developed for rectangular channels can be used for can geometries.

  9. Dynamic rigidity transition

    NASA Astrophysics Data System (ADS)

    Åström, J. A.; Latva-Kokko, M.; Timonen, J.

    2003-01-01

    An inflated closed loop (or membrane) is used to demonstrate a dynamic rigidity transition that occurs when impact energy is added to the loop in static equilibrium at zero temperature. The only relevant parameter in this transition is the ratio of the energy needed to collapse the loop and the impact energy. When this ratio is below a threshold value close to unity, the loop collapses into a high-entropy floppy state, and it does not return to the rigid state unless the impact energy can escape. The internal oscillations are in the floppy state dominated by 1/f2 noise. When the ratio is above the threshold, the loop does not collapse, and the internal oscillations resulting from the impact are dominated by the eigenfrequencies of the stretched membrane. In this state, the loop can bounce for a long time. It is still an open question whether bouncing will eventually vanish or whether a stationary bouncing state will be reached. The dynamic transition between the floppy and the rigid state is discontinuous.

  10. NASA metric transition plan

    NASA Technical Reports Server (NTRS)

    1992-01-01

    NASA science publications have used the metric system of measurement since 1970. Although NASA has maintained a metric use policy since 1979, practical constraints have restricted actual use of metric units. In 1988, an amendment to the Metric Conversion Act of 1975 required the Federal Government to adopt the metric system except where impractical. In response to Public Law 100-418 and Executive Order 12770, NASA revised its metric use policy and developed this Metric Transition Plan. NASA's goal is to use the metric system for program development and functional support activities to the greatest practical extent by the end of 1995. The introduction of the metric system into new flight programs will determine the pace of the metric transition. Transition of institutional capabilities and support functions will be phased to enable use of the metric system in flight program development and operations. Externally oriented elements of this plan will introduce and actively support use of the metric system in education, public information, and small business programs. The plan also establishes a procedure for evaluating and approving waivers and exceptions to the required use of the metric system for new programs. Coordination with other Federal agencies and departments (through the Interagency Council on Metric Policy) and industry (directly and through professional societies and interest groups) will identify sources of external support and minimize duplication of effort.

  11. Column continuous transition functions

    NASA Astrophysics Data System (ADS)

    Li, Yangrong

    2007-04-01

    A column continuous transition function is by definition a standard transition function P(t) whose every column is continuous for t[greater-or-equal, slanted]0 in the norm topology of bounded sequence space l[infinity]. We will prove that it has a stable q-matrix and that there exists a one-to-one relationship between column continuous transition functions and increasing integrated semigroups on l[infinity]. Using the theory of integrated semigroups, we give some necessary and sufficient conditions under which the minimal q-function is column continuous, in terms of its generator (of the Markov semigroup) as well as its q-matrix. Furthermore, we will construct all column continuous Q-functions for a conservative, single-exit and column bounded q-matrix Q. As applications, we find that many interesting continuous-time Markov chains (CTMCs), say Feller-Reuter-Riley processes, monotone processes, birth-death processes and branching processes, etc., have column continuity.

  12. Computational Methods for Design, Control and Optimization

    DTIC Science & Technology

    2007-10-01

    34scenario" that applies to channel flows ( Poiseuille flows , Couette flow ) and pipe flows . Over the past 75 years many complex "transition theories" have... Simulation of Turbulent Flows , Springer Verlag, 2005. Additional Publications Supported by this Grant 1. J. Borggaard and T. Iliescu, Approximate Deconvolution...rigorous analysis of design algorithms that combine numerical simulation codes, approximate sensitivity calculations and optimization codes. The fundamental

  13. The transition to agricultural sustainability

    PubMed Central

    Ruttan, Vernon W.

    1999-01-01

    The transition to sustainable growth in agricultural production during the 21st century will take place within the context of a transition to a stable population and a possible transition to a stable level of material consumption. If the world fails to successfully navigate a transition to sustainable growth in agricultural production, the failure will be due more to a failure in the area of institutional innovation than to resource and environmental constraints. PMID:10339524

  14. Visual Analytics Technology Transition Progress

    SciTech Connect

    Scholtz, Jean; Cook, Kristin A.; Whiting, Mark A.; Lemon, Douglas K.; Greenblatt, Howard

    2009-09-23

    The authors provide a description of the transition process for visual analytic tools and contrast this with the transition process for more traditional software tools. This paper takes this into account and describes a user-oriented approach to technology transition including a discussion of key factors that should be considered and adapted to each situation. The progress made in transitioning visual analytic tools in the past five years is described and the challenges that remain are enumerated.

  15. Analyses of some exoplanets' transits and transit timing variations

    NASA Astrophysics Data System (ADS)

    Püsküllü, ćaǧlar; Soydugan, Faruk

    2017-02-01

    We present solutions of the transit light curves and transit timing variations (TTVs) analyses of the exoplanets HAT-P-5b, HAT-P-9b and HAT-P-25b. Transit light curves were collected at Çanakkale Onsekiz Mart University Observatory and TUBITAK National Observatory. The models were produced by WINFITTER program and stellar, planetary and orbital properties were obtained and discussed. We gave new transit times and generated TTVs with them by appending additional data based on Exoplanet Transit Database (ETD). Significant signals at the TTVs were also investigated.

  16. Slow Transit Constipation.

    PubMed

    Wald, Arnold

    2002-08-01

    The diagnosis of slow transit functional constipation is based upon diagnostic testing of patients with idiopathic constipation who responded poorly to conservative measures such as fiber supplements, fluids, and stimulant laxatives. These tests include barium enema or colonoscopy, colonic transit of radio-opaque markers, anorectal manometry, and expulsion of a water-filled balloon. Plain abdominal films can identify megacolon, which can be further characterized by barium or gastrografin studies. Colonic transit of radio-opaque markers identifies patients with slow transit with stasis of markers in the proximal colon. However, anorectal function should be characterized to exclude outlet dysfunction, which may coexist with colonic inertia. Because slow colonic transit is defined by studies during which patients consume a high-fiber diet, fiber supplements are generally not effective, nor are osmotic laxatives that consist of unabsorbed sugars. Stimulant laxatives are considered first-line therapy, although studies often show a diminished colonic motor response to such agents. There is no evidence to suggest that chronic use of such laxatives is harmful if they are used two to three times per week. Polyethylene glycol with or without electrolytes may be useful in a minority of patients, often combined with misoprostol. I prefer to start with misoprostol 200 mg every other morning and increase to tolerance or efficacy. I see no advantage in prescribing misoprostol on a TID or QID basis or even daily because it increases cramping unnecessarily. This drug is not acceptable in young women who wish to become pregnant. An alternative may be colchicine, which is reported to be effective when given as 0.6 mg TID. Long-term efficacy has not been studied. Finally, biofeedback is a risk-free approach that has been reported as effective in approximately 60% of patients with slow transit constipation in the absence of outlet dysfunction. Although difficult to understand

  17. Components of Comprehensive and Effective Transitional Care.

    PubMed

    Naylor, Mary D; Shaid, Elizabeth C; Carpenter, Deborah; Gass, Brianna; Levine, Carol; Li, Jing; Malley, Ann; McCauley, Kathleen; Nguyen, Huong Q; Watson, Heather; Brock, Jane; Mittman, Brian; Jack, Brian; Mitchell, Suzanne; Callicoatte, Becky; Schall, John; Williams, Mark V

    2017-04-03

    Transitional care (TC) has received widespread attention from researchers, health system leaders, clinicians, and policy makers as they attempt to improve health outcomes and reduce preventable hospital readmissions, yet little is known about the critical elements of effective TC and how they relate to patients' and caregivers' needs and experiences. To address this gap, the Patient-Centered Outcomes Research Institute (PCORI) funded a national study, Achieving patient-centered Care and optimized Health In care transitions by Evaluating the Value of Evidence (Project ACHIEVE). A primary aim of the study is the identification of TC components that yield desired patient and caregiver outcomes. Project ACHIEVE established a multistakeholder workgroup to recommend essential TC components for vulnerable Medicare beneficiaries. Guided by a review of published evidence, the workgroup identified and defined a preliminary set of components and then analyzed how well the set aligned with real-world patients' and caregivers' experiences. Through this process, the workgroup identified eight TC components: patient engagement, caregiver engagement, complexity and medication management, patient education, caregiver education, patients' and caregivers' well-being, care continuity, and accountability. Although the degree of attention given to each component will vary based on the specific needs of patients and caregivers, workgroup members agree that health systems need to address all components to ensure optimal TC for all Medicare beneficiaries.

  18. Particle Swarm Optimization Toolbox

    NASA Technical Reports Server (NTRS)

    Grant, Michael J.

    2010-01-01

    The Particle Swarm Optimization Toolbox is a library of evolutionary optimization tools developed in the MATLAB environment. The algorithms contained in the library include a genetic algorithm (GA), a single-objective particle swarm optimizer (SOPSO), and a multi-objective particle swarm optimizer (MOPSO). Development focused on both the SOPSO and MOPSO. A GA was included mainly for comparison purposes, and the particle swarm optimizers appeared to perform better for a wide variety of optimization problems. All algorithms are capable of performing unconstrained and constrained optimization. The particle swarm optimizers are capable of performing single and multi-objective optimization. The SOPSO and MOPSO algorithms are based on swarming theory and bird-flocking patterns to search the trade space for the optimal solution or optimal trade in competing objectives. The MOPSO generates Pareto fronts for objectives that are in competition. A GA, based on Darwin evolutionary theory, is also included in the library. The GA consists of individuals that form a population in the design space. The population mates to form offspring at new locations in the design space. These offspring contain traits from both of the parents. The algorithm is based on this combination of traits from parents to hopefully provide an improved solution than either of the original parents. As the algorithm progresses, individuals that hold these optimal traits will emerge as the optimal solutions. Due to the generic design of all optimization algorithms, each algorithm interfaces with a user-supplied objective function. This function serves as a "black-box" to the optimizers in which the only purpose of this function is to evaluate solutions provided by the optimizers. Hence, the user-supplied function can be numerical simulations, analytical functions, etc., since the specific detail of this function is of no concern to the optimizer. These algorithms were originally developed to support entry

  19. Alameda-Contra Costa Transit District (AC Transit) Fuel Cell Transit Buses: Preliminary Evaluation Results

    SciTech Connect

    Chandler, K.; Eudy, L.

    2007-03-01

    This report provides an evaluation of three prototype fuel cell-powered transit buses operating at AC Transit in Oakland, California, and six baseline diesel buses similar in design to the fuel cell buses.

  20. Structural transitions in nanoscale systems

    NASA Astrophysics Data System (ADS)

    Yoon, Mina

    In this work I investigate three different materials: nanoscale carbon systems, ferrofluid systems, and molecular-electronic devices. In particular, my study is focused on the theoretical understanding of structural changes and the associated electronic, mechanical, and magnetic properties of these materials. To study the equilibrium packing of fullerenes in carbon nanotube peapods optimization techniques were applied. In agreement with experimental measurements, my results for nanotubes containing fullerenes with 60--84 atoms indicate that the axial separation between the fullerenes is smaller than in the bulk crystal. The reduction of the inter-fullerene distance and also the structural relaxation of fullerenes result from a large internal pressure within the peapods. This naturally induced "static" pressure may qualify nanotubes as nanoscale autoclaves for chemical reactions. Combining total energy calculations with a search of phase space, I investigated the microscopic fusion mechanism of C60 fullerenes. I show that the (2+2) cycloaddition reaction, a necessary precursor for fullerene fusion, can be accelerated inside a nanotube. Fusion occurs along the minimum energy path as a finite sequence of Stone-Wales (SW) transformations. A detailed analysis of the transition states shows that Stone-Wales transformations are multi-step processes. I propose a new microscopic mechanism to explain the unusually fast fusion process of carbon nanotubes. The detailed pathway for two adjacent (5, 5) nanotubes to gradually merge into a (10, 10) tube, and the transition states have been identified. The propagation of the fused region is energetically favorable and proceeds in a morphology reminiscent of a Y-junction via a so called zipper mechanism, involving only SW bond rearrangements with low activation barriers. Using density functional theory, the equilibrium structure, stability, and electronic properties of nanostructured, hydrogen terminated diamond fragments have been

  1. Aristos Optimization Package

    SciTech Connect

    Ridzal, Danis

    2007-03-01

    Aristos is a Trilinos package for nonlinear continuous optimization, based on full-space sequential quadratic programming (SQP) methods. Aristos is specifically designed for the solution of large-scale constrained optimization problems in which the linearized constraint equations require iterative (i.e. inexact) linear solver techniques. Aristos' unique feature is an efficient handling of inexactness in linear system solves. Aristos currently supports the solution of equality-constrained convex and nonconvex optimization problems. It has been used successfully in the area of PDE-constrained optimization, for the solution of nonlinear optimal control, optimal design, and inverse problems.

  2. Interactive visualization and analysis of transitional flow.

    PubMed

    Johnson, Gregory P; Calo, Victor M; Gaither, Kelly P

    2008-01-01

    A stand-alone visualization application has been developed by a multi-disciplinary, collaborative team with the sole purpose of creating an interactive exploration environment allowing turbulent flow researchers to experiment and validate hypotheses using visualization. This system has specific optimizations made in data management, caching computations, and visualization allowing for the interactive exploration of datasets on the order of 1TB in size. Using this application, the user (co-author Calo) is able to interactively visualize and analyze all regions of a transitional flow volume, including the laminar, transitional and fully turbulent regions. The underlying goal of the visualizations produced from these transitional flow simulations is to localize turbulent spots in the laminar region of the boundary layer, determine under which conditions they form, and follow their evolution. The initiation of turbulent spots, which ultimately lead to full turbulence, was located via a proposed feature detection condition and verified by experimental results. The conditions under which these turbulent spots form and coalesce are validated and presented.

  3. Solar diameter with 2012 Venus Transit

    NASA Astrophysics Data System (ADS)

    Sigismondi, C.

    2012-06-01

    The role of Venus and Mercury transits is crucial to know the past history of the solar diameter. Through the W parameter, the logarithmic derivative of the radius with respect to the luminosity, the past values of the solar luminosity can be recovered. The black drop phenomenon affects the evaluation of the instants of internal and external contacts between the planetary disk and the solar limb. With these observed instants compared with the ephemerides the value of the solar diameter is recovered. The black drop and seeing effects are overcome with two fitting circles, to Venus and to the Sun, drawn in the undistorted part of the image. The corrections of ephemerides due to the atmospheric refraction will also be taken into account. The forthcoming transit of Venus will allow an accuracy on the diameter of the Sun better than 0.01 arcsec, with good images of the ingress and of the egress taken each second. Chinese solar observatories are in the optimal conditions to obtain valuable data for the measurement of the solar diameter with the Venus transit of 5/6 June 2012 with an unprecedented accuracy, and with absolute calibration given by the ephemerides.

  4. Measuring Solar Diameter with 2012 Venus Transits

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    The role of Venus and Mercury transits is crucial to know the past history of the solar diameter. Through the W parameter, the logarithmic derivative of the radius with respect to the luminosity, the past values of the solar luminosity can be recovered. The black drop phenomenon affects the evaluation of the instants of internal and external contacts between the planetary disk and the solar limb. With these observed instants compared with the ephemerides the value of the solar diameter is recovered. The black drop and seeing effects are overcome with two fitting circles, to Venus and to the Sun, drawn in the undistorted part of the image. The corrections of ephemerides due to the atmospheric refraction will also be taken into account. The forthcoming transit of Venus will allow an accuracy on the diameter of the Sun better than 0.01 arcsec, with good images of the ingress and of the egress taken each second. Chinese solar observatories are in the optimal conditions to obtain valuable data for the measurement of the solar diameter with the Venus transit of 5/6 June 2012 with an unprecedented accuracy, and with absolute calibration given by the ephemerides.

  5. Non-linear education gradient across the nutrition transition: mothers’ overweight and the population education transition

    PubMed Central

    Salinas, Daniel; Baker, David P

    2015-01-01

    Objective Previous studies found that developed and developing countries present opposite education-overweight gradients but have not considered the dynamics at different levels of national development. A U-inverted curve is hypothesized to best describe the education-overweight association. It is also hypothesized that as the nutrition transition unfolds within nations the shape of education-overweight curve change. Design Multi-level logistic regression estimates the moderating effect of the nutrition transition at the population level on education-overweight gradient. At the individual level, a non-linear estimate of the education association assesses the optimal functional form of the association across the nutrition transition. Setting Twenty-two administrations of the Demographic and Health Survey, collected at different time points across the nutrition transition in nine Latin American/Caribbean countries. Subjects Mothers of reproductive age (15–49) in each administration (n 143,258). Results In the pooled sample, a non-linear education gradient on mothers‘ overweight is found; each additional year of schooling increases the probability of being overweight up to the end of primary schooling, after which each additional year of schooling decreases the probability of overweight. Also, as access to diets of high animal fats and sweeteners increases over time, the curve‘s critical point moves to lower education levels, the detrimental positive effect of education diminishes, and both occur as the overall risk of overweight increases with greater access to harmful diets. Conclusions Both hypotheses are supported. As the nutrition transition progresses, the education-overweight curve steadily shifts to a negative linear association with higher average risk of overweight; and education, at increasingly lower levels, acts as a “social vaccine” against increasing risk of overweight. These empirical patterns fit the general “population education

  6. Pivotal Transitions - Historical and Today

    NASA Astrophysics Data System (ADS)

    Hurley, M.

    2008-08-01

    The goal of this paper is to enable readers to better "design" successful transitions that move Science and Technology or Research and Development (S&T/R&D) technologies and systems into operational capabilities for users. Transitions from S&T/R&D into acquisition and operations are challenging and critical to providing capab ilities to end users. Two historical examples, the Global Positioning System (GPS) and the Disaster Monitoring Constellation (DMC), are explored. Two current examples are also explored, including one from Operationally Responsive Space (ORS) which is in th e early stages of transition. While transitions are necessary, transition periods are inherently challenging and dynamically changing situations. These situations must be carefully managed and led in order to succeed. Characteristics, approaches, and incentives that foster effective transitions are discussed. Understanding the transition process and the communities involved allows one to maximize the chance of successfully moving an S&T/R&D development into an operational capability supporting end users.

  7. A translational evaluation of transitions.

    PubMed

    Jessel, Joshua; Hanley, Gregory P; Ghaemmaghami, Mahshid

    2016-06-01

    Transitions with nonhuman animals are typically framed as inescapable changes in signaled reinforcement schedules that result in a pause in responding unique to switches from rich to lean schedules. Pausing is considered to be a function of the aversive qualities of the contrasting reinforcement schedules. Transitions are typically framed in applied research as physical changes in location that evoke problem behavior maintained by the escape of an aversive event or resumption of a preferred event. We attempted to extend the basic framing of transitions to behaviors and contexts of social significance and evaluate a novel treatment for the problem of dawdling by 3 boys who had been diagnosed with autism spectrum disorder during rich-to-lean transitions. Dawdling during physical transitions was most readily observed when transitioning to lean contexts in Experiment 1. We then shortened transition duration in Experiment 2 by programming unsignaled and probabilistic rich reinforcement in the upcoming context.

  8. MINEHOUND: transition to production

    NASA Astrophysics Data System (ADS)

    Daniels, David J.; Curtis, Paul; Hunt, Nigel; Braunstein, Jürgen; Merz, Armin

    2007-04-01

    The UK Department for International Development (DfID), in collaboration with the German Foreign Ministry (Auswärtiges Amt), contracted ERA Technology to carry out extensive field trials in Cambodia, Bosnia and Angola of an advanced technology, dual sensor, and hand-held landmine detector system called MINEHOUND TM. This detector combines a metal detector with a Ground Penetrating Radar (GPR). As a result of extremely successful trials MINEHOUND TM was developed as a product by ERA Technology and Vallon GmbH and has been available for sale since late 2006. This paper describes the transition to production of the detector.

  9. Transition Path Theory

    NASA Astrophysics Data System (ADS)

    vanden-Eijnden, E.

    The dynamical behavior of many systems arising in physics, chemistry, biology, etc. is dominated by rare but important transition events between long lived states. For over 70 years, transition state theory (TST) has provided the main theoretical framework for the description of these events [17,33,34]. Yet, while TST and evolutions thereof based on the reactive flux formalism [1, 5] (see also [30,31]) give an accurate estimate of the transition rate of a reaction, at least in principle, the theory tells very little in terms of the mechanism of this reaction. Recent advances, such as transition path sampling (TPS) of Bolhuis, Chandler, Dellago, and Geissler [3, 7] or the action method of Elber [15, 16], may seem to go beyond TST in that respect: these techniques allow indeed to sample the ensemble of reactive trajectories, i.e. the trajectories by which the reaction occurs. And yet, the reactive trajectories may again be rather uninformative about the mechanism of the reaction. This may sound paradoxical at first: what more than actual reactive trajectories could one need to understand a reaction? The problem, however, is that the reactive trajectories by themselves give only a very indirect information about the statistical properties of these trajectories. This is similar to why statistical mechanics is not simply a footnote in books about classical mechanics. What is the probability density that a trajectory be at a given location in state-space conditional on it being reactive? What is the probability current of these reactive trajectories? What is their rate of appearance? These are the questions of interest and they are not easy to answer directly from the ensemble of reactive trajectories. The right framework to tackle these questions also goes beyond standard equilibrium statistical mechanics because of the nontrivial bias that the very definition of the reactive trajectories imply - they must be involved in a reaction. The aim of this chapter is to

  10. Transition Metal Switchable Mirror

    SciTech Connect

    2009-01-01

    The switchable-mirrors technology was developed by Tom Richardson and Jonathan Slack of Berkeley Lab's Environmental Energy Technologies Division. By using transition metals rather than the rare earth metals used in the first metal-hydride switchable mirrors, Richardson and Slack were able to lower the cost and simplify the manufacturing process. Energy performance is improved as well, because the new windows can reflect or transmit both visible and infrared light. Besides windows for offices and homes, possible applications include automobile sunroofs, signs and displays, aircraft windows, and spacecraft. More information at: http://windows.lbl.gov/materials/chromogenics/default.htm

  11. Transition Metal Switchable Mirror

    SciTech Connect

    2009-08-21

    The switchable-mirrors technology was developed by Tom Richardson and Jonathan Slack of Berkeley Lab's Environmental Energy Technologies Division. By using transition metals rather than the rare earth metals used in the first metal-hydride switchable mirrors, Richardson and Slack were able to lower the cost and simplify the manufacturing process. Energy performance is improved as well, because the new windows can reflect or transmit both visible and infrared light. Besides windows for offices and homes, possible applications include automobile sunroofs, signs and displays, aircraft windows, and spacecraft.

  12. Transition Metal Switchable Mirror

    ScienceCinema

    None

    2016-07-12

    The switchable-mirrors technology was developed by Tom Richardson and Jonathan Slack of Berkeley Lab's Environmental Energy Technologies Division. By using transition metals rather than the rare earth metals used in the first metal-hydride switchable mirrors, Richardson and Slack were able to lower the cost and simplify the manufacturing process. Energy performance is improved as well, because the new windows can reflect or transmit both visible and infrared light. Besides windows for offices and homes, possible applications include automobile sunroofs, signs and displays, aircraft windows, and spacecraft. More information at: http://windows.lbl.gov/materials/chromogenics/default.htm

  13. Transition Metal Switchable Mirror

    ScienceCinema

    None

    2016-07-12

    The switchable-mirrors technology was developed by Tom Richardson and Jonathan Slack of Berkeley Lab's Environmental Energy Technologies Division. By using transition metals rather than the rare earth metals used in the first metal-hydride switchable mirrors, Richardson and Slack were able to lower the cost and simplify the manufacturing process. Energy performance is improved as well, because the new windows can reflect or transmit both visible and infrared light. Besides windows for offices and homes, possible applications include automobile sunroofs, signs and displays, aircraft windows, and spacecraft.

  14. Multidisciplinary Optimization for Aerospace Using Genetic Optimization

    NASA Technical Reports Server (NTRS)

    Pak, Chan-gi; Hahn, Edward E.; Herrera, Claudia Y.

    2007-01-01

    In support of the ARMD guidelines NASA's Dryden Flight Research Center is developing a multidisciplinary design and optimization tool This tool will leverage existing tools and practices, and allow the easy integration and adoption of new state-of-the-art software. Optimization has made its way into many mainstream applications. For example NASTRAN(TradeMark) has its solution sequence 200 for Design Optimization, and MATLAB(TradeMark) has an Optimization Tool box. Other packages, such as ZAERO(TradeMark) aeroelastic panel code and the CFL3D(TradeMark) Navier-Stokes solver have no built in optimizer. The goal of the tool development is to generate a central executive capable of using disparate software packages ina cross platform network environment so as to quickly perform optimization and design tasks in a cohesive streamlined manner. A provided figure (Figure 1) shows a typical set of tools and their relation to the central executive. Optimization can take place within each individual too, or in a loop between the executive and the tool, or both.

  15. Optimally controlling the human connectome: the role of network topology

    PubMed Central

    Betzel, Richard F.; Gu, Shi; Medaglia, John D.; Pasqualetti, Fabio; Bassett, Danielle S.

    2016-01-01

    To meet ongoing cognitive demands, the human brain must seamlessly transition from one brain state to another, in the process drawing on different cognitive systems. How does the brain’s network of anatomical connections help facilitate such transitions? Which features of this network contribute to making one transition easy and another transition difficult? Here, we address these questions using network control theory. We calculate the optimal input signals to drive the brain to and from states dominated by different cognitive systems. The input signals allow us to assess the contributions made by different brain regions. We show that such contributions, which we measure as energy, are correlated with regions’ weighted degrees. We also show that the network communicability, a measure of direct and indirect connectedness between brain regions, predicts the extent to which brain regions compensate when input to another region is suppressed. Finally, we identify optimal states in which the brain should start (and finish) in order to minimize transition energy. We show that the optimal target states display high activity in hub regions, implicating the brain’s rich club. Furthermore, when rich club organization is destroyed, the energy cost associated with state transitions increases significantly, demonstrating that it is the richness of brain regions that makes them ideal targets. PMID:27468904

  16. Planet Demographics from Transits

    NASA Astrophysics Data System (ADS)

    Howard, Andrew

    2015-08-01

    From the demographics of planets detected by the Kepler mission, we have learned that there exists approximately one planet per star for planets larger than Earth orbiting inside of 1 AU. We have also learned the relative occurrence of these planets as a function of their orbital periods, sizes, and host star masses and metallicities. In this talk I will review the key statistical findings that the planet size distribution peaks in the range 1-3 times Earth-size, the orbital period distribution is characterized by a power-law cut off at short periods, small planets are more prevalent around small stars, and that approximately 20% of Sun-like stars hosts a planet 1-2 times Earth-size in a habitable zone. Looking forward, I will describe analysis of photometry from the K2 mission that is yielding initial planet discoveries and offering the opportunity to measure planet occurrence in widely separated regions of the galaxy. Finally, I will also discuss recent techniques to discover transiting planets in space-based photometry and to infer planet population properties from the ensemble of detected and non-detected transit signals.

  17. Physicians in transition.

    PubMed

    Bluestein, P

    1995-12-01

    The study of physicians as managed care executives has been relatively recent. Much of what was written in the past focused primarily on doctors who had taken hospital-based administrative positions, especially as medical directors or vice presidents of medical affairs.1 But the '80s brought rising health care costs and the emergence of the "O's"--HMOs, PPOs, UROs, EPOs, PHOs, H2Os, and Uh-Ohs--in response. It also brought a growing number of physicians who traded their white coats and their particular "ologies" for the blue suits of executive management. I am convinced that it is important now, and will be increasingly important in the future, to better understand that transition. That belief led me to undertake, with the help and support of ACPE, the survey that is reported in this article. A questionnaire was sent in 1994 to a random sample of 300 managed care physician executive members of ACPE. Responses were returned by 225 members, a response rate of better than 80 percent. Twenty-five of the responses were not applicable, having been returned by physicians who had never made a transition from clinical careers. The remaining 230 responses form the basis for this report.

  18. 309 Building transition plan

    SciTech Connect

    Graves, C.E.

    1994-08-31

    The preparation for decontamination and decommissioning (transition) of the 309 Building is projected to be completed by the end of the fiscal year (FY) 1998. The major stabilization and decontamination efforts include the Plutonium Recycle Test Reactor (PRTR), fuel storage and transfer pits, Transfer Waste (TW) tanks and the Ion Exchange Vaults. In addition to stabilizing contaminated areas, equipment, components, records, waste products, etc., will be dispositioned. All nonessential systems, i.e., heating, ventilation, and air conditioning (HVAC), electrical, monitoring, fluids, etc., will be shut down and drained/de-energized. This will allow securing of the process, laboratory, and office areas of the facility. After that, the facility will be operated at a level commensurate with its surveillance needs while awaiting D&D. The implementation costs for FY 1995 through FY 1998 for the transition activities are estimated to be $1,070K, $2,115K, $2,939K, and $4,762K, respectively. Costs include an assumed company overhead of 20% and a 30% out year contingency.

  19. Fluctuations and Redundancy in Optimal Transport Networks

    NASA Astrophysics Data System (ADS)

    Corson, Francis

    2010-01-01

    The structure of networks that provide optimal transport properties has been investigated in a variety of contexts. While many different formulations of this problem have been considered, it is recurrently found that optimal networks are trees. It is shown here that this result is contingent on the assumption of a stationary flow through the network. When time variations or fluctuations are allowed for, a different class of optimal structures is found, which share the hierarchical organization of trees yet contain loops. The transitions between different network topologies as the parameters of the problem vary are examined. These results may have strong implications for the structure and formation of natural networks, as is illustrated by the example of leaf venation networks.

  20. Optimal probabilistic search

    SciTech Connect

    Lokutsievskiy, Lev V

    2011-05-31

    This paper is concerned with the optimal search of an object at rest with unknown exact position in the n-dimensional space. A necessary condition for optimality of a trajectory is obtained. An explicit form of a differential equation for an optimal trajectory is found while searching over R-strongly convex sets. An existence theorem is also established. Bibliography: 8 titles.

  1. High pressure phase transition and elastic properties of americium telluride

    NASA Astrophysics Data System (ADS)

    Aynyas, Mahendra; Rukmangad, Aditi; Arya, B. S.; Sanyal, S. P.

    2013-06-01

    The structural and elastic properties of Americium Telluride (AmTe) have been investigated by using a modified inter-ionic potential theory (MIPT). This theory is capable of explaining first order phase transition with a crystallographic change NaCl to CsCl structure for this compound. The values of optimized lattice constant, phase transition pressure, zero pressure bulk modulus and second order elastic constants (C11, C44) agree well with their corresponding experimental data. Debye temperature (θD) is also calculated for this compound for the first time.

  2. Aircraft configuration optimization including optimized flight profiles

    NASA Technical Reports Server (NTRS)

    Mccullers, L. A.

    1984-01-01

    The Flight Optimization System (FLOPS) is an aircraft configuration optimization program developed for use in conceptual design of new aircraft and in the assessment of the impact of advanced technology. The modular makeup of the program is illustrated. It contains modules for preliminary weights estimation, preliminary aerodynamics, detailed mission performance, takeoff and landing, and execution control. An optimization module is used to drive the overall design and in defining optimized profiles in the mission performance. Propulsion data, usually received from engine manufacturers, are used in both the mission performance and the takeoff and landing analyses. Although executed as a single in-core program, the modules are stored separately so that the user may select the appropriate modules (e.g., fighter weights versus transport weights) or leave out modules that are not needed.

  3. Heuristic optimization of the scanning path of particle therapy beams.

    PubMed

    Pardo, J; Donetti, M; Bourhaleb, F; Ansarinejad, A; Attili, A; Cirio, R; Garella, M A; Giordanengo, S; Givehchi, N; La Rosa, A; Marchetto, F; Monaco, V; Pecka, A; Peroni, C; Russo, G; Sacchi, R

    2009-06-01

    Quasidiscrete scanning is a delivery strategy for proton and ion beam therapy in which the beam is turned off when a slice is finished and a new energy must be set but not during the scanning between consecutive spots. Different scanning paths lead to different dose distributions due to the contribution of the unintended transit dose between spots. In this work an algorithm to optimize the scanning path for quasidiscrete scanned beams is presented. The classical simulated annealing algorithm is used. It is a heuristic algorithm frequently used in combinatorial optimization problems, which allows us to obtain nearly optimal solutions in acceptable running times. A study focused on the best choice of operational parameters on which the algorithm performance depends is presented. The convergence properties of the algorithm have been further improved by using the next-neighbor algorithm to generate the starting paths. Scanning paths for two clinical treatments have been optimized. The optimized paths are found to be shorter than the back-and-forth, top-to-bottom (zigzag) paths generally provided by the treatment planning systems. The gamma method has been applied to quantify the improvement achieved on the dose distribution. Results show a reduction of the transit dose when the optimized paths are used. The benefit is clear especially when the fluence per spot is low, as in the case of repainting. The minimization of the transit dose can potentially allow the use of higher beam intensities, thus decreasing the treatment time. The algorithm implemented for this work can optimize efficiently the scanning path of quasidiscrete scanned particle beams. Optimized scanning paths decrease the transit dose and lead to better dose distributions.

  4. Optimal driving of Bose-Einstein condensates in optical cavities

    SciTech Connect

    Caneva, T.; Calarco, T.; Montangero, S.

    2014-12-04

    We apply quantum optimal control to enhance the performance of the experimental setup of Ref. [1], speeding up the system dynamics at time scales of the order of the quantum speed limit. We perform a fast crossing of the quantum phase transition the system undergoes under realistic experimental conditions, and we present a new scaling-based strategy to compute optimal pulses for systems at the thermodynamical limit.

  5. Optimization of computations

    SciTech Connect

    Mikhalevich, V.S.; Sergienko, I.V.; Zadiraka, V.K.; Babich, M.D.

    1994-11-01

    This article examines some topics of optimization of computations, which have been discussed at 25 seminar-schools and symposia organized by the V.M. Glushkov Institute of Cybernetics of the Ukrainian Academy of Sciences since 1969. We describe the main directions in the development of computational mathematics and present some of our own results that reflect a certain design conception of speed-optimal and accuracy-optimal (or nearly optimal) algorithms for various classes of problems, as well as a certain approach to optimization of computer computations.

  6. Hope, optimism and delusion

    PubMed Central

    McGuire-Snieckus, Rebecca

    2014-01-01

    Optimism is generally accepted by psychiatrists, psychologists and other caring professionals as a feature of mental health. Interventions typically rely on cognitive-behavioural tools to encourage individuals to ‘stop negative thought cycles’ and to ‘challenge unhelpful thoughts’. However, evidence suggests that most individuals have persistent biases of optimism and that excessive optimism is not conducive to mental health. How helpful is it to facilitate optimism in individuals who are likely to exhibit biases of optimism already? By locating the cause of distress at the individual level and ‘unhelpful’ cognitions, does this minimise wider systemic social and economic influences on mental health? PMID:25237497

  7. Transit Timing Study of Kepler Planets

    NASA Astrophysics Data System (ADS)

    Xie, Jiwei

    2015-08-01

    Kepler space telescope has found over 4000 transiting planet candidates. Transit timing is a powerful tool to study these transit planet candidates. In this talk, I will talk about two transit timing techniques, i.e., transit timing variation (TTV) and transit duration (TD), which enable confirming their planetary nature and obtaining insight into their orbital properties.

  8. Sampling Policy that Guarantees Reliability of Optimal Policy in Reinforcement Learning

    NASA Astrophysics Data System (ADS)

    Senda, Kei; Iwasaki, Yoshimitsu; Fujii, Shinji

    This study defines the certification sampling that guarantees with specified reliability the optimal policy being correct to the real transition probability, where the optimal policy was derived from a estimated probability. It then discusses the sampling policy as follows that efficiently obtains the certification sampling. The the transition probability is estimated by sampling, and it leads the optimal policy. On the other hand, it calculates the desired accuracy of the estimated transition probability that is necessary to guarantee the correct optimal policy. This study proposes the sampling policy that efficiently achieves the certification sampling with the desired accuracy of the estimated transition probability. The proposed method is efficient in number of samples because it automatically selects states and actions to be sampled and stops sampling when the condition is satisfied.

  9. Particle Swarm Optimization

    NASA Technical Reports Server (NTRS)

    Venter, Gerhard; Sobieszczanski-Sobieski Jaroslaw

    2002-01-01

    The purpose of this paper is to show how the search algorithm known as particle swarm optimization performs. Here, particle swarm optimization is applied to structural design problems, but the method has a much wider range of possible applications. The paper's new contributions are improvements to the particle swarm optimization algorithm and conclusions and recommendations as to the utility of the algorithm, Results of numerical experiments for both continuous and discrete applications are presented in the paper. The results indicate that the particle swarm optimization algorithm does locate the constrained minimum design in continuous applications with very good precision, albeit at a much higher computational cost than that of a typical gradient based optimizer. However, the true potential of particle swarm optimization is primarily in applications with discrete and/or discontinuous functions and variables. Additionally, particle swarm optimization has the potential of efficient computation with very large numbers of concurrently operating processors.

  10. Integrated controls design optimization

    DOEpatents

    Lou, Xinsheng; Neuschaefer, Carl H.

    2015-09-01

    A control system (207) for optimizing a chemical looping process of a power plant includes an optimizer (420), an income algorithm (230) and a cost algorithm (225) and a chemical looping process models. The process models are used to predict the process outputs from process input variables. Some of the process in puts and output variables are related to the income of the plant; and some others are related to the cost of the plant operations. The income algorithm (230) provides an income input to the optimizer (420) based on a plurality of input parameters (215) of the power plant. The cost algorithm (225) provides a cost input to the optimizer (420) based on a plurality of output parameters (220) of the power plant. The optimizer (420) determines an optimized operating parameter solution based on at least one of the income input and the cost input, and supplies the optimized operating parameter solution to the power plant.

  11. Partnership Transitions and Maternal Parenting

    PubMed Central

    Beck, Audrey N.; Cooper, Carey E.; McLanahan, Sara; Brooks-Gunn, Jeanne

    2011-01-01

    We use data from the Fragile Families and Child Wellbeing Study (N = 1,975) to examine the association between mothers’ partnership changes and parenting behavior during the first five years of their children’s lives. We compare coresidential with dating transitions, and recent with more distal transitions. We also examine interactions between transitions and race/ethnicity, maternal education and family structure at birth. Findings indicate that both coresidential and dating transitions were associated with higher levels of maternal stress and harsh parenting; recent transitions had stronger associations than distal transitions. Maternal education significantly moderates these associations, with less educated mothers responding more negatively to instability in terms of maternal stress, and more educated mothers responding more negatively in terms of literacy activities. PMID:21423848

  12. Pubertal transitions in health.

    PubMed

    Patton, George C; Viner, Russell

    2007-03-31

    Puberty is accompanied by physical, psychological, and emotional changes adapted to ensure reproductive and parenting success. Human puberty stands out in the animal world for its association with brain maturation and physical growth. Its effects on health and wellbeing are profound and paradoxical. On the one hand, physical maturation propels an individual into adolescence with peaks in strength, speed, and fitness. Clinicians have viewed puberty as a point of maturing out of childhood-onset conditions. However, puberty's relevance for health has shifted with a modern rise in psychosocial disorders of young people. It marks a transition in risks for depression and other mental disorders, psychosomatic syndromes, substance misuse, and antisocial behaviours. Recent secular trends in these psychosocial disorders coincide with a growing mismatch between biological and social maturation, and the emergence of more dominant youth cultures.

  13. Nonadiabatic transition path sampling

    NASA Astrophysics Data System (ADS)

    Sherman, M. C.; Corcelli, S. A.

    2016-07-01

    Fewest-switches surface hopping (FSSH) is combined with transition path sampling (TPS) to produce a new method called nonadiabatic path sampling (NAPS). The NAPS method is validated on a model electron transfer system coupled to a Langevin bath. Numerically exact rate constants are computed using the reactive flux (RF) method over a broad range of solvent frictions that span from the energy diffusion (low friction) regime to the spatial diffusion (high friction) regime. The NAPS method is shown to quantitatively reproduce the RF benchmark rate constants over the full range of solvent friction. Integrating FSSH within the TPS framework expands the applicability of both approaches and creates a new method that will be helpful in determining detailed mechanisms for nonadiabatic reactions in the condensed-phase.

  14. Phases and Phase Transitions

    NASA Astrophysics Data System (ADS)

    Gitterman, Moshe

    2014-09-01

    In discussing phase transitions, the first thing that we have to do is to define a phase. This is a concept from thermodynamics and statistical mechanics, where a phase is defined as a homogeneous system. As a simple example, let us consider instant coffee. This consists of coffee powder dissolved in water, and after stirring it we have a homogeneous mixture, i.e., a single phase. If we add to a cup of coffee a spoonful of sugar and stir it well, we still have a single phase -- sweet coffee. However, if we add ten spoonfuls of sugar, then the contents of the cup will no longer be homogeneous, but rather a mixture of two homogeneous systems or phases, sweet liquid coffee on top and coffee-flavored wet sugar at the bottom...

  15. Hybrid Electric Transit Bus

    NASA Technical Reports Server (NTRS)

    Viterna, Larry A.

    1997-01-01

    A government, industry, and university cooperative is developing an advanced hybrid electric city transit bus. Goals of this effort include doubling the fuel economy compared to current buses and reducing emissions to one-tenth of current EPA standards. Unique aspects of the vehicle's power system include the use of ultra-capacitors as an energy storage system, and a planned natural gas fueled turbogenerator developed from a small jet engine. Power from both the generator and energy storage system is provided to a variable speed electric motor attached to the rear axle. At over 15000 kg gross weight, this is the largest vehicle of its kind ever built using ultra-capacitor energy storage. This paper describes the overall power system architecture, the evolution of the control strategy, and its performance over industry standard drive cycles.

  16. Approximating random quantum optimization problems

    NASA Astrophysics Data System (ADS)

    Hsu, B.; Laumann, C. R.; Läuchli, A. M.; Moessner, R.; Sondhi, S. L.

    2013-06-01

    We report a cluster of results regarding the difficulty of finding approximate ground states to typical instances of the quantum satisfiability problem k-body quantum satisfiability (k-QSAT) on large random graphs. As an approximation strategy, we optimize the solution space over “classical” product states, which in turn introduces a novel autonomous classical optimization problem, PSAT, over a space of continuous degrees of freedom rather than discrete bits. Our central results are (i) the derivation of a set of bounds and approximations in various limits of the problem, several of which we believe may be amenable to a rigorous treatment; (ii) a demonstration that an approximation based on a greedy algorithm borrowed from the study of frustrated magnetism performs well over a wide range in parameter space, and its performance reflects the structure of the solution space of random k-QSAT. Simulated annealing exhibits metastability in similar “hard” regions of parameter space; and (iii) a generalization of belief propagation algorithms introduced for classical problems to the case of continuous spins. This yields both approximate solutions, as well as insights into the free energy “landscape” of the approximation problem, including a so-called dynamical transition near the satisfiability threshold. Taken together, these results allow us to elucidate the phase diagram of random k-QSAT in a two-dimensional energy-density-clause-density space.

  17. Sharp transitions in low-number quantum dots Bayesian magnetometry

    PubMed Central

    Mazurek, Paweł; Horodecki, Michał; Czekaj, Łukasz; Horodecki, Paweł

    2016-01-01

    We consider Bayesian estimate of static magnetic field, characterized by a prior Gaussian probability distribution, in systems of a few electron quantum dot spins interacting with infinite temperature spin environment via hyperfine interaction. Sudden transitions among optimal states and measurements are observed. Usefulness of measuring occupation levels is shown for all times of the evolution, together with the role of entanglement in the optimal scenario. For low values of magnetic field, memory effects stemming from the interaction with environment provide limited metrological advantage. PMID:27686417

  18. Transit satellite system timing capabilities

    NASA Technical Reports Server (NTRS)

    Finsod, T. D.

    1978-01-01

    Current time transfer capabilities of the Transit Satellite System are reviewed. Potential improvements in the changes in equipment and operational procedures using operational satellites are discussed.

  19. Diverse types of percolation transitions

    NASA Astrophysics Data System (ADS)

    Lee, Deokjae; Cho, Y. S.; Kahng, B.

    2016-12-01

    Percolation has long served as a model for diverse phenomena and systems. The percolation transition, that is, the formation of a giant cluster on a macroscopic scale, is known as one of the most robust continuous transitions. Recently, however, many abrupt percolation transitions have been observed in complex systems. To illustrate such phenomena, considerable effort has been made to introduce models and construct theoretical frameworks for explosive, discontinuous, and hybrid percolation transitions. Experimental results have also been reported. In this review article, we describe such percolation models, their critical behaviors and universal features, and real-world phenomena.

  20. Transit administration and planning research

    SciTech Connect

    de Corla-Souza; Gupta.

    1989-01-01

    The 10 papers in the report deal with the following areas: Evaluation of demand-management strategies for Toledo's year 2010 transportation plan; Accommodating deaf and hard-of-hearing persons on public transportation systems in Massachusetts; Quick approach to compare highway and bus transit alternatives using the arterial analysis package; Panel survey approach to measuring transit route service elasticity of demand; UMTA and major investments: evaluation process and results; Using early performance to project transit route ridership: comparison of methods; Institutional requirements for competition: labor issues; Updating ride checks with multiple point checks; Producing section 15 service-consumed data: challenge for large transit; Parkrose targeted marketing campaign pass-incentive program.

  1. Transit clairvoyance: enhancing TESS follow-up using artificial neural networks

    NASA Astrophysics Data System (ADS)

    Kipping, David M.; Lam, Christopher

    2017-03-01

    The upcoming Transiting Exoplanet Survey Satellite (TESS) mission is expected to find thousands of transiting planets around bright stars, yet for three-quarters of the fields observed the temporal coverage will limit discoveries to planets with orbital periods below 13.7 d. From the Kepler catalogue, the mean probability of these short-period transiting planets having additional longer period transiters (which would be missed by TESS) is 18 per cent, a value 10 times higher than the average star. In this work, we show how this probability is not uniform but functionally dependent upon the properties of the observed short-period transiters, ranging from less than 1 per cent up to over 50 per cent. Using artificial neural networks (ANNs) trained on the Kepler catalogue and making careful feature selection to account for the differing sensitivity of TESS, we are able to predict the most likely short-period transiters to be accompanied by additional transiters. Through cross-validation, we predict that a targeted, optimized TESS transit and/or radial velocity follow-up programme using our trained ANN would have a discovery yield improved by a factor of 2. Our work enables a near-optimal follow-up strategy for surveys following TESS targets for additional planets, improving the science yield derived from TESS and particularly beneficial in the search for habitable-zone transiting worlds.

  2. Health Care Transition Experiences of Young Adults With Cerebral Palsy.

    PubMed

    Carroll, Ellen McLaughlin

    2015-01-01

    Health care transition (HCT) describes the purposeful, planned movement of adolescents from child to adult-orientated care. The purpose of this qualitative study is to uncover the meaning of transition to adult-centered care as experienced by young adults with cerebral palsy (YA-CP) through the research question: What are the lived experiences of young adults with cerebral palsy transitioning from pediatric to adult healthcare? Six females and 3 males, aged 19-25 years of age, who identified as carrying the diagnosis of cerebral palsy without cognitive impairment, were interviewed. Giorgi's (1985) method for analysis of phenomenology was the framework for the study and guided the phenomenological reduction. The meaning of the lived experiences of YA-CPs transition to adult health care is expert novices with evidence and experience-based expectations, negotiating new systems interdependently and accepting less than was expected. More information and support is needed for the YA-CP during transition to ensure a well-organized move to appropriate adult-oriented health care that is considerate of the lifelong impact of the disorder. The nurses' role as advocate, mentor and guide can optimize the individual's response to the transition process.

  3. Essentials of Transition Planning. Brookes Transition to Adulthood Series

    ERIC Educational Resources Information Center

    Wehman, Paul

    2011-01-01

    For young people with disabilities, crossing the bridge to adulthood will be empowering instead of intimidating--when their support teams know the essentials of effective transition planning. Now all the fundamentals of well-crafted transition plans are collected in one concise quick-guide, straight from one of the top authorities on helping young…

  4. Transitions to Least Restrictive Environments: A Guide to Transition. Revised.

    ERIC Educational Resources Information Center

    Beninghof, Anne M.

    This guide to the transition of special education students to less restrictive environments or from school to work stresses the importance of planning and communication during the entire process, from initial plans through implementation and follow-up. Section 1 consists of a "Transition Process Checklist" to aid in the organization and follow…

  5. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    SciTech Connect

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  6. Phase transitions in disordered systems

    NASA Astrophysics Data System (ADS)

    Hrahsheh, Fawaz Y.

    Disorder can have a wide variety of consequences for the physics of phase transitions. Some transitions remain unchanged in the presence of disorder while others are completely destroyed. In this thesis we study the effects of disorder on several classical and quantum phase transitions in condensed matter systems. After a brief introduction, we study the ferromagnetic phase transition in a randomly layered Heisenberg magnet using large-scale Monte-Carlo simulations. Our results provide numerical evidence for the exotic infinite-randomness scenario. We study classical and quantum smeared phase transitions in substitutional alloys A1-xBx. Our results show that the disorder completely destroys the phase transition with a pronounced tail of the ordered phase developing for all compositions x < 1. In addition, we find that short-ranged disorder correlations can have a dramatic effect on the transition. Moreover, we show an experimental realization of the composition-tuned ferromagnetic-to-paramagnetic quantum phase transition in Sr1-xCa xRuO3. We investigate the effects of disorder on first-order quantum phase transitions on the example of the N-color quantum Ashkin-Teller model. By means of a strong disorder renormalization group, we demonstrate that disorder rounds the first-order transition to a continuous one for both weak and strong coupling between the colors. Finally, we investigate the superfluid-insulator quantum phase transition of one-dimensional bosons with off-diagonal disorder by means of large-scale Monte-Carlo simulations. Beyond a critical disorder strength, we find nonuniversal, disorder dependent critical behavior.

  7. Light Scattering in Exoplanet Transits

    NASA Astrophysics Data System (ADS)

    Robinson, Tyler D.; Fortney, Jonathan J.

    2016-10-01

    Transit spectroscopy is currently the leading technique for studying exoplanet atmospheric composition, and has led to the detection of molecular species, clouds, and/or hazes for numerous worlds outside the Solar System. The field of exoplanet transit spectroscopy will be revolutionized with the anticipated launch of NASA's James Webb Space Telescope (JWST) in 2018. Over the course of the design five year mission for JWST, the observatory is expected to provide in-depth observations of many tens of transiting exoplanets, including some worlds in the poorly understood 2-4 Earth-mass regime. As the quality of transit spectrum observations continues to improve, so should models of exoplanet transits. Thus, certain processes initially thought to be of second-order importance should be revisited and possibly added to modeling tools. For example, atmospheric refraction, which was commonly omitted from early transit spectrum models, has recently been shown to be of critical importance in some terrestrial exoplanet transits. Beyond refraction, another process that has seen little study with regards to exoplanet transits is light multiple scattering. In most cases, scattering opacity in exoplanet transits has been treated as equivalent to absorption opacity. However, this equivalence cannot always hold, such as in the case of a strongly forward scattering, weakly absorbing aerosol. In this presentation, we outline a theory of exoplanet transit spectroscopy that spans the geometric limit (used in most modern models) to a fully multiple scattering approach. We discuss a new technique for improving model efficiency that effectively separates photon paths, which tend to vary slowly in wavelength, from photon absorption, which can vary rapidly in wavelength. Using this newly developed approach, we explore situations where cloud or haze scattering may be important to JWST observations of gas giants, and comment on the conditions necessary for scattering to become a major

  8. Optimal divergence-free inflow perturbations in flow over an airfoil

    NASA Astrophysics Data System (ADS)

    Loh, Sean; Blackburn, Hugh; Mao, Xuerui

    2013-11-01

    Linear transient growth analysis has identified various key mechanisms in transition due to free-stream turbulence in canonical flow open flow configurations (Durbin & Wu, 2007). In the present work, the role of inflow disturbances in promoting transition for flow over airfoil type geometries is examined. Using an optimal control based methodology, optimal divergence-free inflow perturbations for linear transient energy growth are computed for a NACA 0012 airfoil at 4° angle of attack. At various low-to-moderate Reynolds numbers, the flow response to optimal two-dimensional inflow perturbations with varying streamwise length scale is analysed. The relationship between the flow physics induced by optimal inflow perturbations, optimal initial perturbations and leading linear instability modes is then examined. Durbin P & Wu X (2007), Transition beneath vortical disturbances, Annu. Rev. Fluid Mech. 39: 107. Supported by Australian Research Council grant DP1094851.

  9. Transitions in the Communication Capacity of Dissipative Qubit Channels

    NASA Astrophysics Data System (ADS)

    Daems, D.

    2009-05-01

    The information transmission is studied for quantum channels in which the noise includes dissipative effects, more specifically, nonunitality. Noise is usually a nuisance but can sometimes be helpful. For these channels, the communication capacity is shown to increase with the dissipative component of the noise and may exhibit transitions beyond which it increases faster. The optimal states are constructed analytically as well as the pertaining “phase” diagram.

  10. Rapid Mars transits with exhaust-modulated plasma propulsion

    NASA Technical Reports Server (NTRS)

    Chang-Diaz, Franklin R.; Braden, Ellen; Johnson, Ivan; Hsu, Michael M.; Yang, Tien Fang

    1995-01-01

    The operational characteristics of the Exhaust-Modulated Plasma Rocket are described. Four basic human and robotic mission scenarios to Mars are analyzed using numerical optimization techniques at variable specific impulse and constant power. The device is well suited for 'split-sprint' missions, allowing fast, one-way low-payload human transits of 90 to 104 days, as well as slower, 180-day, high-payload robotic precursor flights. Abort capabilities, essential for human missions, are also explored.

  11. Supercomputer optimizations for stochastic optimal control applications

    NASA Technical Reports Server (NTRS)

    Chung, Siu-Leung; Hanson, Floyd B.; Xu, Huihuang

    1991-01-01

    Supercomputer optimizations for a computational method of solving stochastic, multibody, dynamic programming problems are presented. The computational method is valid for a general class of optimal control problems that are nonlinear, multibody dynamical systems, perturbed by general Markov noise in continuous time, i.e., nonsmooth Gaussian as well as jump Poisson random white noise. Optimization techniques for vector multiprocessors or vectorizing supercomputers include advanced data structures, loop restructuring, loop collapsing, blocking, and compiler directives. These advanced computing techniques and superconducting hardware help alleviate Bellman's curse of dimensionality in dynamic programming computations, by permitting the solution of large multibody problems. Possible applications include lumped flight dynamics models for uncertain environments, such as large scale and background random aerospace fluctuations.

  12. Detection by Transit Photometry

    NASA Technical Reports Server (NTRS)

    Borucki, William J.; Koch, David G.; Jenkins, Jon M.; DeVincenzi, D. (Technical Monitor)

    2002-01-01

    A periodic sequence of planetary transits provides a valid detection of an orbiting planet and provides the relative size of the planet and its orbital period. Ancillary measurements of the stellar spectrum and the variations of the star's radial velocity or position combined with stellar models allow the absolute size of the planet and its mass to be obtained. The results of this approach have already shown that the planet orbiting HD209458 has only 70% of the mass of Jupiter, but is nearly 50% larger in radius. Based on models of planetary structure, these results imply that the planet must have spent most of its lifetime so close to the star that it has not been able to cool and contract as have the giant planets in our Solar System. Thus its density is much less than Jupiter and Saturn and is actually less than that of water; i.e., about 0.4 gr/cu cm. If more sensitive measurements of the light curve of stars with closely orbiting planets can be made that provide the varying amplitude of the light reflected by the planet at various phases in its orbit, then characteristics of the planetary atmosphere can be obtained. Potentially, these data can identify major molecular species present in the atmosphere and tell us if clouds are present and yield the phase function of the aerosols. Although such detail cannot be obtained for Earth-size planets because their signal amplitudes are too small, it is possible to get data critical to the determination of the structure of extrasolar planetary systems. In particular, the size distributions and their orbital distributions can be measured by the transit photometry missions now in development. The COROT mission should be able to find large terrestrial planets in short-period orbits while the more ambitious Kepler and Eddington missions should be able to detect planets even smaller than the Earth and at orbital distances that place them in the habitable zone of their stars.

  13. Search-based optimization.

    PubMed

    Wheeler, Ward C

    2003-08-01

    The problem of determining the minimum cost hypothetical ancestral sequences for a given cladogram is known to be NP-complete (Wang and Jiang, 1994). Traditionally, point estimations of hypothetical ancestral sequences have been used to gain heuristic, upper bounds on cladogram cost. These include procedures with such diverse approaches as non-additive optimization of multiple sequence alignment, direct optimization (Wheeler, 1996), and fixed-state character optimization (Wheeler, 1999). A method is proposed here which, by extending fixed-state character optimization, replaces the estimation process with a search. This form of optimization examines a diversity of potential state solutions for cost-efficient hypothetical ancestral sequences and can result in greatly more parsimonious cladograms. Additionally, such an approach can be applied to other NP-complete phylogenetic optimization problems such as genomic break-point analysis.

  14. Search-based optimization

    NASA Technical Reports Server (NTRS)

    Wheeler, Ward C.

    2003-01-01

    The problem of determining the minimum cost hypothetical ancestral sequences for a given cladogram is known to be NP-complete (Wang and Jiang, 1994). Traditionally, point estimations of hypothetical ancestral sequences have been used to gain heuristic, upper bounds on cladogram cost. These include procedures with such diverse approaches as non-additive optimization of multiple sequence alignment, direct optimization (Wheeler, 1996), and fixed-state character optimization (Wheeler, 1999). A method is proposed here which, by extending fixed-state character optimization, replaces the estimation process with a search. This form of optimization examines a diversity of potential state solutions for cost-efficient hypothetical ancestral sequences and can result in greatly more parsimonious cladograms. Additionally, such an approach can be applied to other NP-complete phylogenetic optimization problems such as genomic break-point analysis. c2003 The Willi Hennig Society. Published by Elsevier Science (USA). All rights reserved.

  15. Energy optimization system

    DOEpatents

    Zhou, Zhi; de Bedout, Juan Manuel; Kern, John Michael; Biyik, Emrah; Chandra, Ramu Sharat

    2013-01-22

    A system for optimizing customer utility usage in a utility network of customer sites, each having one or more utility devices, where customer site is communicated between each of the customer sites and an optimization server having software for optimizing customer utility usage over one or more networks, including private and public networks. A customer site model for each of the customer sites is generated based upon the customer site information, and the customer utility usage is optimized based upon the customer site information and the customer site model. The optimization server can be hosted by an external source or within the customer site. In addition, the optimization processing can be partitioned between the customer site and an external source.

  16. Optimization and optimal statistics in neuroscience

    NASA Astrophysics Data System (ADS)

    Brookings, Ted

    Complex systems have certain common properties, with power law statistics being nearly ubiquitous. Despite this commonality, we show that a variety of mechanisms can be responsible for complexity, illustrated by the example of a lattice on a Cayley Tree. Because of this, analysis must probe more deeply than merely looking for power laws, instead details of the dynamics must be examined. We show how optimality---a frequently-overlooked source of complexity---can produce typical features such as power laws, and describe inherent trade-offs in optimal systems, such as performance vs. robustness to rare disturbances. When applied to biological systems such as the nervous system, optimality is particularly appropriate because so many systems have identifiable purpose. We show that the "grid cells" in rats are extremely efficient in storing position information. Assuming the system to be optimal allows us to describe the number and organization of grid cells. By analyzing systems from an optimal perspective provides insights that permit description of features that would otherwise be difficult to observe. As well, careful analysis of complex systems requires diligent avoidance of assumptions that are unnecessary or unsupported. Attributing unwarranted meaning to ambiguous features, or assuming the existence of a priori constraints may quickly lead to faulty results. By eschewing unwarranted and unnecessary assumptions about the distribution of neural activity and instead carefully integrating information from EEG and fMRI, we are able to dramatically improve the quality of source-localization. Thus maintaining a watchful eye towards principles of optimality, while avoiding unnecessary statistical assumptions is an effective theoretical approach to neuroscience.

  17. Case report: microcystic transitional cell carcinoma of the urinary bladder.

    PubMed

    Radopoulos, Demetrios; Kalyvas, Konstantinos; Kotakidou, Rodi; Panagiotopoulou, Konstantina; Katsikas, Vasilios; Papathanasiou, Michalis

    2005-01-01

    We report a rare case of microcystic transitional cell carcinoma involving the urinary bladder, in a 38-year-old man, and we add our experience in the treatment of this neoplasm. The tumor was muscle invasive, and a radical cystectomy was performed. The patient received no postoperative chemotherapy or radiotherapy, and he has not signs of local recurrence or distal metastasis after 3 years of intense follow up. Even though the number of cases documented so far, is insufficient to draw safe conclusions regarding the optimal treatment of the microcystic variant of transitional cell carcinoma. Our case indicates that even in cases of microcystic transitional cell carcinoma with infiltrative nature, aggressive therapy is associated with good control of the disease locally and distally.

  18. Catalytic mechanism of transition-metal compounds on Mg hydrogen sorption reaction.

    PubMed

    Barkhordarian, Gagik; Klassen, Thomas; Bormann, Rüdiger

    2006-06-08

    The catalytic mechanisms of transition-metal compounds during the hydrogen sorption reaction of magnesium-based hydrides were investigated through relevant experiments. Catalytic activity was found to be influenced by four distinct physico-thermodynamic properties of the transition-metal compound: a high number of structural defects, a low stability of the compound, which however has to be high enough to avoid complete reduction of the transition metal under operating conditions, a high valence state of the transition-metal ion within the compound, and a high affinity of the transition-metal ion to hydrogen. On the basis of these results, further optimization of the selection of catalysts for improving sorption properties of magnesium-based hydrides is possible. In addition, utilization of transition-metal compounds as catalysts for other hydrogen storage materials is considered.

  19. Homotopy optimization methods for global optimization.

    SciTech Connect

    Dunlavy, Daniel M.; O'Leary, Dianne P. (University of Maryland, College Park, MD)

    2005-12-01

    We define a new method for global optimization, the Homotopy Optimization Method (HOM). This method differs from previous homotopy and continuation methods in that its aim is to find a minimizer for each of a set of values of the homotopy parameter, rather than to follow a path of minimizers. We define a second method, called HOPE, by allowing HOM to follow an ensemble of points obtained by perturbation of previous ones. We relate this new method to standard methods such as simulated annealing and show under what circumstances it is superior. We present results of extensive numerical experiments demonstrating performance of HOM and HOPE.

  20. Transition Planning for Foster Youth

    ERIC Educational Resources Information Center

    Geenen, Sarah J.; Powers, Laurie E.

    2006-01-01

    The study evaluated the IEPs/Individualized Transition Plans of 45 students who were in special education and foster care, and compared them to the plans of 45 students who were in special education only. Results indicate that the transition plans of foster youth with disabilities were poor in quality, both in absolute terms and in comparison to…

  1. Adult Transition Program without Walls

    ERIC Educational Resources Information Center

    Moberg, Eric

    2010-01-01

    Best practices in adult transition special education for moderate to severe students suggest student-centered planning that maximizes independence in adult life. Based on the above sources, school districts and governing boards would best serve moderate to severe transition special education students with increasing integration into the community…

  2. Nonadiabatic transitions and gauge structure

    SciTech Connect

    Nakamura, K. ); Rice, S.A. )

    1994-04-01

    We examine the role of fictitious gauge structure in nonadiabatic transitions for transport in open paths. Local features of the gauge potential modify the nature of the intersection of the adiabatic energy surfaces and thereby affect crucially the Landau-Zener formula for a single-passage transition rate.

  3. Role Transitions in Small Groups.

    ERIC Educational Resources Information Center

    Moreland, Richard L.; Levine, John M.

    This paper analyzes role transitions in small groups within the context of a more general model of group socialization that is based on the psychological processes of evaluation, commitment, and decision making. The major advantage of such an approach is that it specifies why role transitions in small groups occur. According to the model, groups…

  4. Conceptual design optimization study

    NASA Technical Reports Server (NTRS)

    Hollowell, S. J.; Beeman, E. R., II; Hiyama, R. M.

    1990-01-01

    The feasibility of applying multilevel functional decomposition and optimization techniques to conceptual design of advanced fighter aircraft was investigated. Applying the functional decomposition techniques to the conceptual design phase appears to be feasible. The initial implementation of the modified design process will optimize wing design variables. A hybrid approach, combining functional decomposition techniques for generation of aerodynamic and mass properties linear sensitivity derivatives with existing techniques for sizing mission performance and optimization, is proposed.

  5. Transition-Independent Decentralized Markov Decision Processes

    NASA Technical Reports Server (NTRS)

    Becker, Raphen; Silberstein, Shlomo; Lesser, Victor; Goldman, Claudia V.; Morris, Robert (Technical Monitor)

    2003-01-01

    There has been substantial progress with formal models for sequential decision making by individual agents using the Markov decision process (MDP). However, similar treatment of multi-agent systems is lacking. A recent complexity result, showing that solving decentralized MDPs is NEXP-hard, provides a partial explanation. To overcome this complexity barrier, we identify a general class of transition-independent decentralized MDPs that is widely applicable. The class consists of independent collaborating agents that are tied up by a global reward function that depends on both of their histories. We present a novel algorithm for solving this class of problems and examine its properties. The result is the first effective technique to solve optimally a class of decentralized MDPs. This lays the foundation for further work in this area on both exact and approximate solutions.

  6. LAMPF transition-region mechanical fabrication

    SciTech Connect

    Bush, E.D. Jr.; Gallegos, J.D.F.; Harrison, R.; Hart, V.E.; Hunter, W.T.; Rislove, S.E.; Sims, J.R.; Van Dyke, W.J.

    1984-07-01

    The primary purpose of the new Transition Region (TR-II) is to optimize the phase matching of the H/sup +/ and H/sup -/ beams during simultaneous transport. TR-II incorporates several design improvements that include larger aperture, a straight beam track, greater beam-path length adjustments, and utility lines integrated with the support system. The close pack density of magnets and beam-line hardware required innovative solutions to magnet design and mounting, vacuum manifolding, and utility routing. Critical magnet placement was accomplished using a new three-dimensional alignment system that does real-time vector calculations on a computer with input from two digital theodolites. All assembly and a large fraction of the mechanical fabrication were done by LAMPF personnel. The TR-II has been operational since September 1983 and routinely transports production beams up to 900-..mu..A current with no major problems.

  7. MODEL UPDATING: TRANSITION FROM RESEARCH TO PRACTICE?

    SciTech Connect

    D. C. ZIMMERMAN; F. M. HEMEZ

    2000-10-01

    This session offers an open forum to discuss issues associated with the transition of nearly two decades of engineering research into computational guided model updating into industry state-of-the-practice. Related technical issues are the model updating technology, model reduction, test-analysis correlation and optimization strategies. The session is organized as follows. Technical presentations review the state-of-the-art in finite element model updating and present examples of industrial applications. The results of a recent survey on the potential and usefulness of the model updating technology are discussed. Panel discussions and interaction with the audience discuss industrial needs, future trends and challenges and why negative model updating results are never discussed within the structural dynamics community.

  8. CosmoTransitions: Computing cosmological phase transition temperatures and bubble profiles with multiple fields

    NASA Astrophysics Data System (ADS)

    Wainwright, Carroll L.

    2012-09-01

    I present a numerical package (CosmoTransitions) for analyzing finite-temperature cosmological phase transitions driven by single or multiple scalar fields. The package analyzes the different vacua of a theory to determine their critical temperatures (where the vacuum energy levels are degenerate), their supercooling temperatures, and the bubble wall profiles which separate the phases and describe their tunneling dynamics. I introduce a new method of path deformation to find the profiles of both thin- and thick-walled bubbles. CosmoTransitions is freely available for public use.Program summaryProgram Title: CosmoTransitionsCatalogue identifier: AEML_v1_0Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEML_v1_0.htmlProgram obtainable from: CPC Program Library, Queen's University, Belfast, N. IrelandLicensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.htmlNo. of lines in distributed program, including test data, etc.: 8775No. of bytes in distributed program, including test data, etc.: 621096Distribution format: tar.gzProgramming language: Python.Computer: Developed on a 2009 MacBook Pro. No computer-specific optimization was performed.Operating system: Designed and tested on Mac OS X 10.6.8. Compatible with any OS with Python installed.RAM: Approximately 50 MB, mostly for loading plotting packages.Classification: 1.9, 11.1.External routines: SciPy, NumPy, matplotLibNature of problem: I describe a program to analyze early-Universe finite-temperature phase transitions with multiple scalar fields. The goal is to analyze the phase structure of an input theory, determine the amount of supercooling at each phase transition, and find the bubble-wall profiles of the nucleated bubbles that drive the transitions.Solution method: To find the bubble-wall profile, the program assumes that tunneling happens along a fixed path in field space. This reduces the equations of motion to one dimension, which can then be solved using the overshoot

  9. Control and optimization system

    DOEpatents

    Xinsheng, Lou

    2013-02-12

    A system for optimizing a power plant includes a chemical loop having an input for receiving an input parameter (270) and an output for outputting an output parameter (280), a control system operably connected to the chemical loop and having a multiple controller part (230) comprising a model-free controller. The control system receives the output parameter (280), optimizes the input parameter (270) based on the received output parameter (280), and outputs an optimized input parameter (270) to the input of the chemical loop to control a process of the chemical loop in an optimized manner.

  10. High-Fidelity Aerodynamic Shape Optimization for Natural Laminar Flow

    NASA Astrophysics Data System (ADS)

    Rashad, Ramy

    To ensure the long-term sustainability of aviation, serious effort is underway to mitigate the escalating economic, environmental, and social concerns of the industry. Significant improvement to the energy efficiency of air transportation is required through the research and development of advanced and unconventional airframe and engine technologies. In the quest to reduce airframe drag, this thesis is concerned with the development and demonstration of an effective design tool for improving the aerodynamic efficiency of subsonic and transonic airfoils. The objective is to advance the state-of-the-art in high-fidelity aerodynamic shape optimization by incorporating and exploiting the phenomenon of laminar-turbulent transition in an efficient manner. A framework for the design and optimization of Natural Laminar Flow (NLF) airfoils is developed and demonstrated with transition prediction capable of accounting for the effects of Reynolds number, freestream turbulence intensity, Mach number, and pressure gradients. First, a two-dimensional Reynolds-averaged Navier-Stokes (RANS) flow solver has been extended to incorporate an iterative laminar-turbulent transition prediction methodology. The natural transition locations due to Tollmien-Schlichting instabilities are predicted using the simplified eN envelope method of Drela and Giles or, alternatively, the compressible form of the Arnal-Habiballah-Delcourt criterion. The boundary-layer properties are obtained directly from the Navier-Stokes flow solution, and the transition to turbulent flow is modeled using an intermittency function in conjunction with the Spalart-Allmaras turbulence model. The RANS solver is subsequently employed in a gradient-based sequential quadratic programming shape optimization framework. The laminar-turbulent transition criteria are tightly coupled into the objective and gradient evaluations. The gradients are obtained using a new augmented discrete-adjoint formulation for non-local transition

  11. Assessing transitional phenomena with the transitional object memory probe.

    PubMed

    Fowler, C; Hilsenroth, M J; Handler, L

    1998-01-01

    Winnicott's concept of transitional relatedness has captured the interest of psychoanalysts because it provides an understanding of the dialectical process occurring between inner and outer reality, and by extension, between analyst and analysand. Clinical observations related to transitional phenomena have led the authors to develop a projective early memory probe that assesses transitional phenomena. The transitional object early memory probe was tested both for its empirical validity and for its clinical utility in psychodynamic psychotherapy. Construct validity was assessed by comparing memory scores to the Rorschach Transitional Object Scale, as well as to therapist ratings of patient behaviors. Results demonstrated moderate correlations between early memory scores and Rorschach scale scores. Equally important was the finding that early memory scores were significantly correlated with therapist ratings of key behavioral patterns in therapy. A case vignette highlights the clinical application of the transitional object probe in assessing the capacity for transitional relatedness. In this case, the data gleaned from the patient's memories provided the therapist with a sharper focus on their role in the patient's growing capacity for more vital and creative contact with reality.

  12. Ant groups optimally amplify the effect of transiently informed individuals.

    PubMed

    Gelblum, Aviram; Pinkoviezky, Itai; Fonio, Ehud; Ghosh, Abhijit; Gov, Nir; Feinerman, Ofer

    2015-07-28

    To cooperatively transport a large load, it is important that carriers conform in their efforts and align their forces. A downside of behavioural conformism is that it may decrease the group's responsiveness to external information. Combining experiment and theory, we show how ants optimize collective transport. On the single-ant scale, optimization stems from decision rules that balance individuality and compliance. Macroscopically, these rules poise the system at the transition between random walk and ballistic motion where the collective response to the steering of a single informed ant is maximized. We relate this peak in response to the divergence of susceptibility at a phase transition. Our theoretical models predict that the ant-load system can be transitioned through the critical point of this mesoscopic system by varying its size; we present experiments supporting these predictions. Our findings show that efficient group-level processes can arise from transient amplification of individual-based knowledge.

  13. Ant groups optimally amplify the effect of transiently informed individuals

    PubMed Central

    Gelblum, Aviram; Pinkoviezky, Itai; Fonio, Ehud; Ghosh, Abhijit; Gov, Nir; Feinerman, Ofer

    2015-01-01

    To cooperatively transport a large load, it is important that carriers conform in their efforts and align their forces. A downside of behavioural conformism is that it may decrease the group's responsiveness to external information. Combining experiment and theory, we show how ants optimize collective transport. On the single-ant scale, optimization stems from decision rules that balance individuality and compliance. Macroscopically, these rules poise the system at the transition between random walk and ballistic motion where the collective response to the steering of a single informed ant is maximized. We relate this peak in response to the divergence of susceptibility at a phase transition. Our theoretical models predict that the ant-load system can be transitioned through the critical point of this mesoscopic system by varying its size; we present experiments supporting these predictions. Our findings show that efficient group-level processes can arise from transient amplification of individual-based knowledge. PMID:26218613

  14. Optimal Disturbances in Boundary Layers Subject to Streamwise Pressure Gradient

    NASA Technical Reports Server (NTRS)

    Tumin, Anatoli; Ashpis, David E.

    2003-01-01

    Laminar-turbulent transition in shear flows is still an enigma in the area of fluid mechanics. The conventional explanation of the phenomenon is based on the instability of the shear flow with respect to infinitesimal disturbances. The conventional hydrodynamic stability theory deals with the analysis of normal modes that might be unstable. The latter circumstance is accompanied by an exponential growth of the disturbances that might lead to laminar-turbulent transition. Nevertheless, in many cases, the transition scenario bypasses the exponential growth stage associated with the normal modes. This type of transition is called bypass transition. An understanding of the phenomenon has eluded us to this day. One possibility is that bypass transition is associated with so-called algebraic (non-modal) growth of disturbances in shear flows. In the present work, an analysis of the optimal disturbances/streamwise vortices associated with the transient growth mechanism is performed for boundary layers in the presence of a streamwise pressure gradient. The theory will provide the optimal spacing of the control elements in the spanwise direction and their placement in the streamwise direction.

  15. Combining Transit and Radial Velocity Data

    NASA Astrophysics Data System (ADS)

    Rogers, Leslie A.

    2016-10-01

    The Kepler Mission, combined with ground based radial velocity (RV) follow-up, has revolutionized the observational constraints on sub-Neptune-size planet compositions. Kepler's unprecedentedly large and homogeneous samples of planets with both mass and radius constraints open the possibility of statistical studies of the underlying planet composition distribution. This presentation describes the application of hierarchical Bayesian models to constrain the underlying planet composition distribution from a sample of noisy mass-radius measurements. This approach represents a promising avenue toward a quantitative measurement of the amount of physical scatter in small planet compositions, the identification of planet sub-populations that may be tied to distinct formation pathways, and empirical constraints on the dominant compositional trends in the planet sample. Both the transit and radial velocity techniques are subject to selection effects, and approaches to mitigate the resulting biases will be addressed. In addition to distilling composition-distribution insights from the current sample of Kepler planets with RV masses, this framework may be used to optimize the target selection for future transiting planet RV follow-up surveys.

  16. The KELT Survey for Transiting Planets

    NASA Astrophysics Data System (ADS)

    Oberst, T. E.; Beatty, T. G.; Bieryla, A.; Bozza, V.; Collins, K.; D'Ago, G.; Eastman, J. D.; Gaudi, B. S.; Jang-Condell, H.; Jensen, E. L. N.; Kielkopf, J.; Lund, M. B.; Manner, M.; McLeod, K. K.; Novati, S. C.; Penny, M. T.; Pepper, J.; Reed, P. A.; Rodriguez, J. E.; Scarpetta, G.; Siverd, R. J.; Stassun, K. G.; Street, R. A.

    2014-03-01

    KELT (the Kilodegree Extremely Little Telescope) is a transit survey for new exoplanets orbiting bright (8 < V < 10) stars. Such systems are ideally suited for high signal-to-noise follow-up studies of planetary atmospheres and compositions by current ground- and spaced-based observatories. KELT consists of two small-aperture, wide-field, robotic telescopes which have been monitoring ~ 50 % of the northern and southern skies for 6 and 3.5 years, respectively. Identification and vetting of candidates is ongoing. The survey has thus far discovered and confirmed three transiting planets - hot Jupiters KELT-2Ab and KELT-3b, and hot Saturn KELT- 6b - as well as the 27 MJ brown dwarf KELT-1b. The KELT Follow-up Network, a collaboration of over 20 amateur and professional astronomers and institutions, is actively confirming additional KELT discoveries. The Network has also started observing other interesting targets. While KELT is optimized for detecting gas giant companions of FGK stars, the Network is helping to observe Kepler-discovered eclipsing binaries and circumbinary planetary systems, potential super-Earths orbiting M dwarfs, and other variable stars and eclipsing binaries.

  17. Management of Klinefelter syndrome during transition.

    PubMed

    Gies, Inge; Unuane, David; Velkeniers, Brigitte; De Schepper, Jean

    2014-08-01

    Klinefelter syndrome (KS) is the most common sex chromosomal disorder in males. Key findings in older adolescents and young men are small testes with variable hypo-androgenism, but almost universal azoospermia, most frequently in combination with a history of learning difficulties and behavior problems. Males with KS may come to medical attention through different medical presentations, given its association with several congenital malformations, and psychiatric, endocrine, and metabolic disorders. Preventive care is to be provided from diagnosis, preferentially through a multidisciplinary approach, including that from an endocrinologist, clinical psychologist or psychiatrist, neurologist, urologist, geneticist, sexologist, and a fertility team. Accurate information about the condition and assessment of associated medical conditions should be offered at diagnosis and should be followed by psychological counseling. Medical treatment during transition into adulthood is focused on fertility preservation and testosterone replacement therapy in the case of hypo-androgenism, and alleviation of current or future consequences of testicular fibrosis. However, more research is needed to determine the need for pro-active testosterone treatment in adolescence, as well as the conditions for an optimal testosterone replacement and sperm retrieval in adolescents and young men with KS. Furthermore, screening for associated diseases such as metabolic syndrome, autoimmune diseases, thyroid dysfunction, and malignancies is warranted during this period of life. The practical medical management during transition and, more specifically, the role of the endocrinologist are discussed in this article.

  18. Design optimization of a magnetorheological brake in powered knee orthosis

    NASA Astrophysics Data System (ADS)

    Ma, Hao; Liao, Wei-Hsin

    2015-04-01

    Magneto-rheological (MR) fluids have been utilized in devices like orthoses and prostheses to generate controllable braking torque. In this paper, a flat shape rotary MR brake is designed for powered knee orthosis to provide adjustable resistance. Multiple disk structure with interior inner coil is adopted in the MR brake configuration. In order to increase the maximal magnetic flux, a novel internal structure design with smooth transition surface is proposed. Based on this design, a parameterized model of the MR brake is built for geometrical optimization. Multiple factors are considered in the optimization objective: braking torque, weight, and, particularly, average power consumption. The optimization is then performed with Finite Element Analysis (FEA), and the optimal design is obtained among the Pareto-optimal set considering the trade-offs in design objectives.

  19. Selenophene transition metal complexes

    SciTech Connect

    White, Carter James

    1994-07-27

    This research shows that selenophene transition metal complexes have a chemistry that is similar to their thiophene analogs. Selenophene coordination has been demonstrated and confirmed by molecular structure in both the η5- and the η1(Se)-coordination modes. The reaction chemistry of selenophene complexes closely resembles that of the analogous thiophene complexes. One major difference, however, is that selenophene is a better donor ligand than thiophene making the selenophene complexes more stable than the corresponding thiophene complexes. The 77Se NMR chemical shift values for selenophene complexes fall within distinct regions primarily depending on the coordination mode of the selenophene ligand. In the final paper, the C-H bond activation of η1(S)-bound thiophenes, η1(S)-benzothiophene and η1(Se)-bound selenophenes has been demonstrated. The deprotonation and rearrangement of the η1(E)-bound ligand to the carbon bound L-yl complex readily occurs in the presence of base. Reprotonation with a strong acid gives a carbene complex that is unreactive towards nucleophilic attack at the carbene carbon and is stable towards exposure to air. The molecular structure of [Cp(NO)(PPh3)Re(2-benzothioenylcarbene)]O3SCF3 was determined and contains a Re-C bond with substantial double bond character. Methyl substitution for the thienylcarbene or selenylcarbene gives a carbene that rearranges thermally to give back the η1(E)-bound complex. Based on these model reactions, a new mechanism for the H/D exchange of thiophene over the hydrodesulfurization catalyst has been proposed.

  20. Unusual spin transitions

    NASA Astrophysics Data System (ADS)

    Ovcharenko, V. I.; Fokin, S. V.; Romanenko, G. V.; Ikorskii, V. N.; Tretyakov, E. V.; Vasilevsky, S. F.; Sagdeev, R. Z.

    New heterospin complexes of Cu(hfac) 2 (hfac, hexafluoroacetylacetonate) with pyrazole-substituted nitronyl nitroxides have been found that in the solid state exhibit thermally induced spin transitions analogous to spin crossover. For the first complex, [Cu(hfac) 2 L i-Pr ], at room temperature, the Cu - O L distances, where O L is the oxygen atom of the nitroxyl group, are very short (2.143 Å). This leads to a strong antiferromagnetic exchange (~-120 cm -1 ) in the > N - •O - Cu 2+ - O •- N< exchange clusters. The CuO 6 coordination units formed by four O atoms of the two hfac anions and by the nitroxyl O atoms of the two bridging nitroxides have a rare form of flattened octahedra, transformed at low temperatures into elongated octahedra with shorter Cu - O L distances (2.143 Å ⇔2.002 Å) and two longer Cu - O hfac distances (2.130 Å ⇔2.293 Å). For the second complex, [Cu(hfac) 2 L Bu ·0.5C 6 H 14 ], unusual low temperature structural dynamics of heterospin systems have been found. It is characterized by the formation of two types of CuO 6 unit. The axial Cu - O L distances are lengthened in one unit (2.250 Å 2.347 Å) and shortened in the other (2.250 Å ⇔2.006 Å). This leads to a sophisticated μeff ( T ) dependence with μeff drastically decreased at 163 K as a result of full coupling of two spins in half of all >N - •O - Cu 2+ - O •- N< exchange clusters and to a shift from antiferromagnetic to ferromagnetic exchange in the other half.

  1. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  2. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  3. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  4. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  5. 22 CFR 41.71 - Transit aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Transit aliens. 41.71 Section 41.71 Foreign... NATIONALITY ACT, AS AMENDED Transit Aliens § 41.71 Transit aliens. (a) Transit aliens—general. An alien is classifiable as a nonimmigrant transit alien under INA 101(a) (15) (C) if the consular officer is...

  6. Elastic swimming I: Optimization

    NASA Astrophysics Data System (ADS)

    Lauga, Eric; Yu, Tony; Hosoi, Anette

    2006-03-01

    We consider the problem of swimming at low Reynolds number by oscillating an elastic filament in a viscous liquid, as investigated by Wiggins and Goldstein (1998, Phys Rev Lett). In this first part of the study, we characterize the optimal forcing conditions of the swimming strategy and its optimal geometrical characteristics.

  7. Electronic Transitions of Yttrium Monophosphide

    NASA Astrophysics Data System (ADS)

    Cheung, Allan S. C.; Li, Biu Wa; Chan, MAN-CHOR

    2015-06-01

    Electronic transition spectrum of the yttrium monophosphide (YP) molecule in the visible region between 715 nm and 880 nm has been recorded using laser ablation/reaction free-jet expansion and laser induced fluorescence spectroscopy. The YP molecule was produced by reacting laser - ablated yttrium atoms with PH3 seeded in argon. Thirteen vibrational bands were analyzed and five electronic transition systems have identified, namely the [12.2] Ω = 3 - X3 Π_2 transition, [13.3] Ω = 3 - X3 Π_2 transition, [13.4] Ω = 3 - X3 Π_2 transition, [13.5] Ω = 3 - X3 Π_2 transition, and [13.4] Ω = 2 - X3 Π_2 transition. Least squares fits of the measured rotational lines yielded molecular constants for the ground and excited states. The ground state symmetry and the bond length r_0 of the YP molecule have been determined to be a X3 Π_2 state and 2.4413 Å respectively in this work. A molecular orbital energy level diagram has been used to help the assignment of the observed electronic states. This work represents the first experimental investigation of the spectrum of the YP molecule.

  8. Observational biases for transiting planets

    NASA Astrophysics Data System (ADS)

    Kipping, David M.; Sandford, Emily

    2016-12-01

    Observational biases distort our view of nature, such that the patterns we see within a surveyed population of interest are often unrepresentative of the truth we seek. Transiting planets currently represent the most informative data set on the ensemble properties of exoplanets within 1 au of their star. However, the transit method is inherently biased due to both geometric and detection-driven effects. In this work, we derive the overall observational biases affecting the most basic transit parameters from first principles. By assuming a trapezoidal transit and using conditional probability, we infer the expected distribution of these terms both as a joint distribution and in a marginalized form. These general analytic results provide a baseline against which to compare trends predicted by mission-tailored injection/recovery simulations and offer a simple way to correct for observational bias. Our results explain why the observed population of transiting planets displays a non-uniform impact parameter distribution, with a bias towards near-equatorial geometries. We also find that the geometric bias towards observed planets transiting near periastron is attenuated by the longer durations which occur near apoastron. Finally, we predict that the observational bias with respect to ratio-of-radii is super-quadratic, scaling as (RP/R⋆)5/2, driven by an enhanced geometric transit probability and modestly longer durations.

  9. The Visibility of Earth Transits

    NASA Technical Reports Server (NTRS)

    Castellano, Timothy P.; Doyle, Laurance; McIntosh, Dawn; DeVincenzi, Donald (Technical Monitor)

    2000-01-01

    The recent photometric detection of planetary transits of the solar-like star HD 209458 at a distance of 47 parsecs suggest that transits can reveal the presence of Jupiter-size planetary companions in the solar neighborhood. Recent space-based transit searches have achieved photometric precision within an order of magnitude of that required to detect the much smaller transit signal of an earth-size planet across a solar-size star. Laboratory experiments in the presence of realistic noise sources have shown that CCDs can achieve photometric precision adequate to detect the 9.6 E-5 dimming of the Sun due to a transit of the Earth. Space-based solar irradiance monitoring has shown that the intrinsic variability of the Sun would not preclude such a detection. Transits of the Sun by the Earth would be detectable by observers that reside within a narrow band of sky positions near the ecliptic plane, if the observers possess current Earth epoch levels of technology and astronomical expertise. A catalog of solar-like stars that satisfy the geometric condition for Earth transit visibility are presented.

  10. The Visibility of Earth Transits

    NASA Technical Reports Server (NTRS)

    Castellano, Tim; DeVincenzi, Donald L. (Technical Monitor)

    2000-01-01

    The recent detection of planetary transits of the solar-like star HD 209458 at a distance of 47 parsecs suggest that transits can reveal the presence of Jupiter-size planetary companions in the solar neighborhood. Recent space-based transit searches have achieved photometric precision within an order of magnitude of that required to detect the much smaller transit signal of an earth-size planet around a solar-size star. Laboratory experiments in the presence of realistic noise sources have shown that CCDs can achieve photometric precision adequate to detect the 9.6 E-5 dimming, of the Sun due to a transit of the Earth. Space-based solar irradiance monitoring has shown that the intrinsic variability of the Sun would not preclude such a detection. Transits of the Sun by the Earth would be detectable by observers that reside within a narrow band of sky positions near the ecliptic plane, if the observers possess current Earth epoch levels of technology and astronomical expertise. A catalog of candidate target stars, their properties, and simulations of the photometric Earth transit signal detectability at each target is presented.

  11. Major evolutionary transitions in individuality

    PubMed Central

    West, Stuart A.; Fisher, Roberta M.; Gardner, Andy; Kiers, E. Toby

    2015-01-01

    The evolution of life on earth has been driven by a small number of major evolutionary transitions. These transitions have been characterized by individuals that could previously replicate independently, cooperating to form a new, more complex life form. For example, archaea and eubacteria formed eukaryotic cells, and cells formed multicellular organisms. However, not all cooperative groups are en route to major transitions. How can we explain why major evolutionary transitions have or haven’t taken place on different branches of the tree of life? We break down major transitions into two steps: the formation of a cooperative group and the transformation of that group into an integrated entity. We show how these steps require cooperation, division of labor, communication, mutual dependence, and negligible within-group conflict. We find that certain ecological conditions and the ways in which groups form have played recurrent roles in driving multiple transitions. In contrast, we find that other factors have played relatively minor roles at many key points, such as within-group kin discrimination and mechanisms to actively repress competition. More generally, by identifying the small number of factors that have driven major transitions, we provide a simpler and more unified description of how life on earth has evolved. PMID:25964342

  12. Reentry trajectory optimization based on a multistage pseudospectral method.

    PubMed

    Zhao, Jiang; Zhou, Rui; Jin, Xuelian

    2014-01-01

    Of the many direct numerical methods, the pseudospectral method serves as an effective tool to solve the reentry trajectory optimization for hypersonic vehicles. However, the traditional pseudospectral method is time-consuming due to large number of discretization points. For the purpose of autonomous and adaptive reentry guidance, the research herein presents a multistage trajectory control strategy based on the pseudospectral method, capable of dealing with the unexpected situations in reentry flight. The strategy typically includes two subproblems: the trajectory estimation and trajectory refining. In each processing stage, the proposed method generates a specified range of trajectory with the transition of the flight state. The full glide trajectory consists of several optimal trajectory sequences. The newly focused geographic constraints in actual flight are discussed thereafter. Numerical examples of free-space flight, target transition flight, and threat avoidance flight are used to show the feasible application of multistage pseudospectral method in reentry trajectory optimization.

  13. Reentry Trajectory Optimization Based on a Multistage Pseudospectral Method

    PubMed Central

    Zhou, Rui; Jin, Xuelian

    2014-01-01

    Of the many direct numerical methods, the pseudospectral method serves as an effective tool to solve the reentry trajectory optimization for hypersonic vehicles. However, the traditional pseudospectral method is time-consuming due to large number of discretization points. For the purpose of autonomous and adaptive reentry guidance, the research herein presents a multistage trajectory control strategy based on the pseudospectral method, capable of dealing with the unexpected situations in reentry flight. The strategy typically includes two subproblems: the trajectory estimation and trajectory refining. In each processing stage, the proposed method generates a specified range of trajectory with the transition of the flight state. The full glide trajectory consists of several optimal trajectory sequences. The newly focused geographic constraints in actual flight are discussed thereafter. Numerical examples of free-space flight, target transition flight, and threat avoidance flight are used to show the feasible application of multistage pseudospectral method in reentry trajectory optimization. PMID:24574929

  14. Complex quantum networks: From universal breakdown to optimal transport.

    PubMed

    Mülken, Oliver; Dolgushev, Maxim; Galiceanu, Mircea

    2016-02-01

    We study the transport efficiency of excitations on complex quantum networks with loops. For this we consider sequentially growing networks with different topologies of the sequential subgraphs. This can lead either to a universal complete breakdown of transport for complete-graph-like sequential subgraphs or to optimal transport for ringlike sequential subgraphs. The transition to optimal transport can be triggered by systematically reducing the number of loops of complete-graph-like sequential subgraphs in a small-world procedure. These effects are explained on the basis of the spectral properties of the network's Hamiltonian. Our theoretical considerations are supported by numerical Monte Carlo simulations for complex quantum networks with a scale-free size distribution of sequential subgraphs and a small-world-type transition to optimal transport.

  15. Complex quantum networks: From universal breakdown to optimal transport

    NASA Astrophysics Data System (ADS)

    Mülken, Oliver; Dolgushev, Maxim; Galiceanu, Mircea

    2016-02-01

    We study the transport efficiency of excitations on complex quantum networks with loops. For this we consider sequentially growing networks with different topologies of the sequential subgraphs. This can lead either to a universal complete breakdown of transport for complete-graph-like sequential subgraphs or to optimal transport for ringlike sequential subgraphs. The transition to optimal transport can be triggered by systematically reducing the number of loops of complete-graph-like sequential subgraphs in a small-world procedure. These effects are explained on the basis of the spectral properties of the network's Hamiltonian. Our theoretical considerations are supported by numerical Monte Carlo simulations for complex quantum networks with a scale-free size distribution of sequential subgraphs and a small-world-type transition to optimal transport.

  16. Optimal stretching of fluid for enhancing reaction growth

    NASA Astrophysics Data System (ADS)

    Nevins, Thomas; Kelley, Douglas

    2016-11-01

    When a biological or chemical scalar grows in flowing fluid, the resulting reacted region is dependent on both the details of the flow, and the reaction kinetics. We simultaneously film reaction state and flow in a laboratory model of reactive mixing in order to examine reactive mixing in physical, time-dependent flows. Using the excitable Belousov-Zhabotinsky (BZ) reaction, we find an optimal stretching range in which the flow enhances reaction, but larger stretching causes reaction blowout. We observe the transition from flow mostly helping to mostly blowout is not associated with the transition to turbulence, and that stretching fields (closely related to finite-time Lyapunov exponents) inside the optimal range appear to have a large effect on reaction growth rate locally. We also present estimates of the optimal stretching for BZ, and hypothesize that it is a feature exclusive to excitable reactions.

  17. Optimal synchronization in space.

    PubMed

    Brede, Markus

    2010-02-01

    In this Rapid Communication we investigate spatially constrained networks that realize optimal synchronization properties. After arguing that spatial constraints can be imposed by limiting the amount of "wire" available to connect nodes distributed in space, we use numerical optimization methods to construct networks that realize different trade offs between optimal synchronization and spatial constraints. Over a large range of parameters such optimal networks are found to have a link length distribution characterized by power-law tails P(l) proportional to l(-alpha), with exponents alpha increasing as the networks become more constrained in space. It is also shown that the optimal networks, which constitute a particular type of small world network, are characterized by the presence of nodes of distinctly larger than average degree around which long-distance links are centered.

  18. Optimal Limited Contingency Planning

    NASA Technical Reports Server (NTRS)

    Meuleau, Nicolas; Smith, David E.

    2003-01-01

    For a given problem, the optimal Markov policy over a finite horizon is a conditional plan containing a potentially large number of branches. However, there are applications where it is desirable to strictly limit the number of decision points and branches in a plan. This raises the question of how one goes about finding optimal plans containing only a limited number of branches. In this paper, we present an any-time algorithm for optimal k-contingency planning. It is the first optimal algorithm for limited contingency planning that is not an explicit enumeration of possible contingent plans. By modelling the problem as a partially observable Markov decision process, it implements the Bellman optimality principle and prunes the solution space. We present experimental results of applying this algorithm to some simple test cases.

  19. Optimal synchronization in space

    NASA Astrophysics Data System (ADS)

    Brede, Markus

    2010-02-01

    In this Rapid Communication we investigate spatially constrained networks that realize optimal synchronization properties. After arguing that spatial constraints can be imposed by limiting the amount of “wire” available to connect nodes distributed in space, we use numerical optimization methods to construct networks that realize different trade offs between optimal synchronization and spatial constraints. Over a large range of parameters such optimal networks are found to have a link length distribution characterized by power-law tails P(l)∝l-α , with exponents α increasing as the networks become more constrained in space. It is also shown that the optimal networks, which constitute a particular type of small world network, are characterized by the presence of nodes of distinctly larger than average degree around which long-distance links are centered.

  20. Algorithms for bilevel optimization

    NASA Technical Reports Server (NTRS)

    Alexandrov, Natalia; Dennis, J. E., Jr.

    1994-01-01

    General multilevel nonlinear optimization problems arise in design of complex systems and can be used as a means of regularization for multi-criteria optimization problems. Here, for clarity in displaying our ideas, we restrict ourselves to general bi-level optimization problems, and we present two solution approaches. Both approaches use a trust-region globalization strategy, and they can be easily extended to handle the general multilevel problem. We make no convexity assumptions, but we do assume that the problem has a nondegenerate feasible set. We consider necessary optimality conditions for the bi-level problem formulations and discuss results that can be extended to obtain multilevel optimization formulations with constraints at each level.

  1. Use of glass transitions in carbohydrate excipient design for lyophilized protein formulations

    PubMed Central

    Roughton, Brock C.; Topp, E.M.; Camarda, Kyle V.

    2013-01-01

    This work describes an effort to apply methods from process systems engineering to a pharmaceutical product design problem, with a novel application of statistical approaches to comparing solutions. A computational molecular design framework was employed to design carbohydrate molecules with high glass transition temperatures and low water content in the maximally freeze-concentrated matrix, with the objective of stabilizing lyophilized protein formulations. Quantitative structure–property relationships were developed for glass transition temperature of the anhydrous solute, glass transition temperature of the maximally concentrated solute, melting point of ice and Gordon–Taylor constant for carbohydrates. An optimization problem was formulated to design an excipient with optimal property values. Use of a stochastic optimization algorithm, Tabu search, provided several carbohydrate excipient candidates with statistically similar property values, as indicated by prediction intervals calculated for each property. PMID:24385675

  2. Fluctuation driven electroweak phase transition

    NASA Technical Reports Server (NTRS)

    Gleiser, Marcelo; Kolb, Edward W.

    1991-01-01

    We examine the dynamics of the electroweak phase transition in the early Universe. For Higgs masses in the range 46 less than or = M sub H less than or = 150 GeV and top quark masses less than 200 GeV, regions of symmetric and asymmetric vacuum coexist to below the critical temperature, with thermal equilibrium between the two phases maintained by fluctuations of both phases. We propose that the transition to the asymmetric vacuum is completed by percolation of these subcritical fluctuations. Our results are relevant to scenarios of baryogenesis that invoke a weakly first-order phase transition at the electroweak scale.

  3. Transition circumnstellar disks in Lupus

    NASA Astrophysics Data System (ADS)

    Romero, G. A.; Schreiber, M. R.; Cieza, L. A.; Rebassa-Manssergas, A.; Williams, J. P.; Merin, B.; Smith-Castelli, A.; Orellana, M.

    2011-10-01

    Based on Spitzer selected YSOs, we present a study of transition disks located in Lupus. Several mechanisms have been proposed to explain their defining characteristic: an inner opacity hole and an optically thick outer disk. These processes are: planet formation, grain growth, photoevaporation, tidal truncation in close binaries. We have carried out Adaptive Optics (AO) imaging, submillimeter photometry, and echelle spectroscopy in order to observationally characterize our transition disk sample. With the analyzed data we can distinguish the four scenarios and identify candidate transition disk systems that are currently forming planets. Such objects are excellent targets to be followed-up with Herschel and ALMA.

  4. Menstruation and the menopausal transition.

    PubMed

    Harlow, Siobán D; Paramsothy, Pangaja

    2011-09-01

    This paper characterizes changes in menstrual bleeding during perimenopause,including bleeding changes that represent markers of the menopausal transition. Recent results from the Study of Women's Health Across the Nation and other cohort studies are reviewed. Emerging data describing subpopulation differences in the transition experience are highlighted. When treating women in the midlife, clinicians should pay careful attention to medical factors, including both conditions and treatments, that may increase menstrual blood loss or alter menstrual cycle characteristics sufficiently to obscure the onset of the menopausal transition or the final menstrual period.

  5. Theory on instability and transition

    NASA Technical Reports Server (NTRS)

    Smith, Frank T.

    1990-01-01

    The fundamental fluid dynamics governing instability and transition to turbulence in boundary layers are considered, and attention is focused on the key aspects of nonlinear dynamics central to the transition process and to turbulent boundary-layer phenomena. Emphasis is placed on truly nonlinear theories, in which the boundary layer mean-flow profile is completely altered from its original form. Nonlinear TS transitions, Euler-stage interactions, and vortex/wave interactions are discussed, and compressible boundary layers are analyzed. Connections with experiments and computations are outlined, along with overall trends including the extension of the nonlinear theory and the advancement in the compressible and other flow regimes.

  6. The 2012 Transit of Venus

    NASA Astrophysics Data System (ADS)

    Deans, P.

    2012-08-01

    On June 5-6, 2012, much of the world will experience an event that will not occur again for another 105 years - a transit of Venus. During the 18th and 19th centuries, astronomers made arduous trips to remote corners of Earth to make Venus transit observations in an attempt to calculate the Earth-Sun distance. Today a transit of Venus is simply a rare spectacle. But it is important to take care when viewing it, because observing the Sun is dangerous if proper filters for eye protection are not used.

  7. Nonradiative transition dynamics in alexandrite

    NASA Technical Reports Server (NTRS)

    Gayen, S. K.; Wang, W. B.; Petricevic, V.; Alfano, R. R.

    1986-01-01

    The first direct picosecond time-resolved measurement of the nonradiative transition dynamics between the excited 4T2 pump band and the metastable 2E storage level of the trivalent chromium ion in alexandrite is reported. The nonradiative relaxation times of 17 ps for intra-4T2 vibrational transitions, and 27 ps for 4T2-2E electronic transition are obtained. The thermal repopulation rate of the 4T2 state from the metastable 2E level is of the order 3.5 x 10 to the 9th per s.

  8. Phase transition in Liouville theory

    SciTech Connect

    Johnston, D. )

    1989-11-15

    We suggest that the vortices arising in a Kosterlitz-Thouless phase transition in Liouville theory correspond to transitions between different genera, producing the plumber's nightmare'' and other phases that have been predicted in fluid membrane theory from energetic considerations. This transition has previously been invoked by Cates to explain the degeneration of numerical simulations of Gaussian random surfaces into branched polymers. The difficulty in quantizing Liouville theory for {ital d}{gt}1 is conjectured to be due to our insistence on working at a fixed genus.

  9. Phase transition in Liouville theory

    NASA Astrophysics Data System (ADS)

    Johnston, D.

    1989-11-01

    We suggest that the vortices arising in a Kosterlitz-Thouless phase transition in Liouville theory correspond to transitions between different genera, producing the ``plumber's nightmare'' and other phases that have been predicted in fluid membrane theory from energetic considerations. This transition has previously been invoked by Cates to explain the degeneration of numerical simulations of Gaussian random surfaces into branched polymers. The difficulty in quantizing Liouville theory for d>1 is conjectured to be due to our insistence on working at a fixed genus.

  10. Reaction Path Optimization with Holonomic Constraints and Kinetic Energy Potentials

    SciTech Connect

    Brokaw, Jason B.; Haas, Kevin R.; Chu, Jhih-wei

    2009-08-11

    Two methods are developed to enhance the stability, efficiency, and robustness of reaction path optimization using a chain of replicas. First, distances between replicas are kept equal during path optimization via holonomic constraints. Finding a reaction path is, thus, transformed into a constrained optimization problem. This approach avoids force projections for finding minimum energy paths (MEPs), and fast-converging schemes such as quasi-Newton methods can be readily applied. Second, we define a new objective function - the total Hamiltonian - for reaction path optimization, by combining the kinetic energy potential of each replica with its potential energy function. Minimizing the total Hamiltonian of a chain determines a minimum Hamiltonian path (MHP). If the distances between replicas are kept equal and a consistent force constant is used, then the kinetic energy potentials of all replicas have the same value. The MHP in this case is the most probable isokinetic path. Our results indicate that low-temperature kinetic energy potentials (<5 K) can be used to prevent the development of kinks during path optimization and can significantly reduce the required steps of minimization by 2-3 times without causing noticeable differences between a MHP and MEP. These methods are applied to three test cases, the C₇eq-to-Cax isomerization of an alanine dipeptide, the ⁴C₁- to-¹C₄ transition of an α-D-glucopyranose, and the helix-to-sheet transition of a GNNQQNY heptapeptide. By applying the methods developed in this work, convergence of reaction path optimization can be achieved for these complex transitions, involving full atomic details and a large number of replicas (>100). For the case of helix-to-sheet transition, we identify pathways whose energy barriers are consistent with experimental measurements. Further, we develop a method based on the work energy theorem to quantify the accuracy of reaction paths and to determine whether the atoms used to define a

  11. Reaction Path Optimization with Holonomic Constraints and Kinetic Energy Potentials.

    PubMed

    Brokaw, Jason B; Haas, Kevin R; Chu, Jhih-Wei

    2009-08-11

    Two methods are developed to enhance the stability, efficiency, and robustness of reaction path optimization using a chain of replicas. First, distances between replicas are kept equal during path optimization via holonomic constraints. Finding a reaction path is, thus, transformed into a constrained optimization problem. This approach avoids force projections for finding minimum energy paths (MEPs), and fast-converging schemes such as quasi-Newton methods can be readily applied. Second, we define a new objective function - the total Hamiltonian - for reaction path optimization, by combining the kinetic energy potential of each replica with its potential energy function. Minimizing the total Hamiltonian of a chain determines a minimum Hamiltonian path (MHP). If the distances between replicas are kept equal and a consistent force constant is used, then the kinetic energy potentials of all replicas have the same value. The MHP in this case is the most probable isokinetic path. Our results indicate that low-temperature kinetic energy potentials (<5 K) can be used to prevent the development of kinks during path optimization and can significantly reduce the required steps of minimization by 2-3 times without causing noticeable differences between a MHP and MEP. These methods are applied to three test cases, the C7eq-to-Cax isomerization of an alanine dipeptide, the (4)C1-to-(1)C4 transition of an α-d-glucopyranose, and the helix-to-sheet transition of a GNNQQNY heptapeptide. By applying the methods developed in this work, convergence of reaction path optimization can be achieved for these complex transitions, involving full atomic details and a large number of replicas (>100). For the case of helix-to-sheet transition, we identify pathways whose energy barriers are consistent with experimental measurements. Further, we develop a method based on the work energy theorem to quantify the accuracy of reaction paths and to determine whether the atoms used to define a path

  12. Unsteady transitions of separation patterns in single expansion ramp nozzle

    NASA Astrophysics Data System (ADS)

    Yu, Y.; Xu, J.; Yu, K.; Mo, J.

    2015-11-01

    The single expansion ramp nozzle is one of the optimal configurations for a planar rocket-based combined cycle engine because of its good integration and self-adaptability at off-design operation. The single expansion ramp nozzle is seriously overexpanded when the vehicle is at low speed, resulting in complex flow separation phenomena. Several separation patterns have been found in the single expansion ramp nozzle. Numerical simulations have shown that the transition between these separation patterns occurs in the nozzle startup and shutdown processes. However, only a few relevant experimental studies have been reported. This study reproduces the nozzle startup and shutdown processes using wind tunnel experiments. Two restricted shock separation patterns are observed in the experiment, namely, a separation bubble either forms on the ramp or the flap. The detailed flow fields in the transition processes are captured using a high-speed camera. The shock wave structures in the two separation patterns, influences of the nozzle pressure ratio (NPR) on the separation patterns and changes of the shock waves in the transition processes are discussed in detail. Shock wave instabilities accompany the separation transition, which usually takes less than 5 ms. The nozzle pressure ratios corresponding to the separation pattern transition are different in the startup and shutdown processes, which leads to a hysteresis effect.

  13. Evolution of weighted complex bus transit networks with flow

    NASA Astrophysics Data System (ADS)

    Huang, Ailing; Xiong, Jie; Shen, Jinsheng; Guan, Wei

    2016-02-01

    Study on the intrinsic properties and evolutional mechanism of urban public transit networks (PTNs) has great significance for transit planning and control, particularly considering passengers’ dynamic behaviors. This paper presents an empirical analysis for exploring the complex properties of Beijing’s weighted bus transit network (BTN) based on passenger flow in L-space, and proposes a bi-level evolution model to simulate the development of transit routes from the view of complex network. The model is an iterative process that is driven by passengers’ travel demands and dual-controlled interest mechanism, which is composed of passengers’ spatio-temporal requirements and cost constraint of transit agencies. Also, the flow’s dynamic behaviors, including the evolutions of travel demand, sectional flow attracted by a new link and flow perturbation triggered in nearby routes, are taken into consideration in the evolutional process. We present the numerical experiment to validate the model, where the main parameters are estimated by using distribution functions that are deduced from real-world data. The results obtained have proven that our model can generate a BTN with complex properties, such as the scale-free behavior or small-world phenomenon, which shows an agreement with our empirical results. Our study’s results can be exploited to optimize the real BTN’s structure and improve the network’s robustness.

  14. Dual Transition Edge Sensor Bolometer for Enhanced Dynamic Range

    NASA Technical Reports Server (NTRS)

    Chervenak, J. A.; Benford, D. J.; Moseley, S. H.; Irwin, K. D.

    2004-01-01

    Broadband surveys at the millimeter and submillimeter wavelengths will require bolometers that can reach new limits of sensitivity and also operate under high background conditions. To address this need, we present results on a dual transition edge sensor (TES) device with two operating modes: one for low background, ultrasensitive detection and one for high background, enhanced dynamic range detection. The device consists of a detector element with two transition temperatures (T(sub c)) of 0.25 and 0.51 K located on the same micromachined, thermally isolated membrane structure. It can be biased on either transition, and features phonon-limited noise performance at the lower T(sub c). We measure noise performance on the lower transition 7 x 10(exp -18) W/rt(Hz) and the bias power on the upper transition of 12.5 pW, giving a factor of 10 enhancement of the dynamic range for the device. We discuss the biasable range of this type of device and present a design concept to optimize utility of the device.

  15. Presence of state transitions in the cryptophyte alga Guillardia theta.

    PubMed

    Cheregi, Otilia; Kotabová, Eva; Prášil, Ondřej; Schröder, Wolfgang P; Kaňa, Radek; Funk, Christiane

    2015-10-01

    Plants and algae have developed various regulatory mechanisms for optimal delivery of excitation energy to the photosystems even during fluctuating light conditions; these include state transitions as well as non-photochemical quenching. The former process maintains the balance by redistributing antennae excitation between the photosystems, meanwhile the latter by dissipating excessive excitation inside the antennae. In the present study, these mechanisms have been analysed in the cryptophyte alga Guillardia theta. Photoprotective non-photochemical quenching was observed in cultures only after they had entered the stationary growth phase. These cells displayed a diminished overall photosynthetic efficiency, measured as CO2 assimilation rate and electron transport rate. However, in the logarithmic growth phase G. theta cells redistributed excitation energy via a mechanism similar to state transitions. These state transitions were triggered by blue light absorbed by the membrane integrated chlorophyll a/c antennae, and green light absorbed by the lumenal biliproteins was ineffective. It is proposed that state transitions in G. theta are induced by small re-arrangements of the intrinsic antennae proteins, resulting in their coupling/uncoupling to the photosystems in state 1 or state 2, respectively. G. theta therefore represents a chromalveolate algae able to perform state transitions.

  16. Recent progress in the development of transition radiation detectors

    NASA Technical Reports Server (NTRS)

    Cherry, M. L.; Hartmann, G.; Prince, T.; Mueller, D.

    1978-01-01

    Transition-radiation detectors have been used in several recent cosmic-ray experiments for particle identification at energies E/mc-squared of at least about 1000. In order to optimize the design of such detectors and to use them for energy measurements over a broad energy range, it is necessary to study the details of the transition-radiation process. Experimental results are presented which test the theoretical predictions more precisely and at higher energies than in previous experiments. The dependence of the interference pattern in the frequency spectrum on the radiator dimensions is studied, and the total transition-radiation yield generated by electrons in various radiators is measured over a very wide energy range, from 5 to 300 GeV. The significance of the individual experimental parameters in the design of transition radiation detectors is reviewed, and the characteristics of transition-radiation detectors capable of measuring particle energies over the range E/mc-squared from about 300 to 100,000 are discussed.

  17. Abrupt transition to complete congestion on complex networks and control.

    PubMed

    Wang, Wen-Xu; Wu, Zhi-Xi; Jiang, Rui; Chen, Guanrong; Lai, Ying-Cheng

    2009-09-01

    Previous works on traffic-flow dynamics on complex networks have mostly focused on continuous phase transition from a free-flow state to a locally congested state as a parameter, such as the packet-generating rate, is increased through a critical value. Above the transition point congestion occurs on a small subset of nodes. Utilizing a conventional traffic-flow model based on the packet birth-death process and more importantly, taking into account the fact that in realistic networks nodes have only finite buffers, we find an abrupt transition from free flow to complete congestion. Slightly below the transition point, the network can support the maximum amount of traffic for some optimal value of the routing parameter. We develop a mean-field theory to explain the surprising transition phenomenon and provide numerical support. Furthermore, we propose a control strategy based on the idea of random packet dropping to prevent/break complete congestion. Our finding provides insights into realistic communication networks where complete congestion can occur directly from a free-flow state without any apparent precursor, and our control strategy can be effective to restore traffic flow once complete congestion has occurred.

  18. Empowering Students in Transition

    PubMed Central

    Sullivan, Ann-Catherine

    2016-01-01

    The purpose of this study was to (a) identify potential benefits for students with disabilities taking part in a physical activity program with same-age typical peers on a Midwest university campus and (b) to determine if the program impacted the students with disabilities empowerment. Empowerment theory was used to determine how transition students’ attitudes change over the course of the semester while participating in a workout buddy program with same-age college peers. The program was structured to provide a sense of empowerment to students to make their own decisions and learn for themselves so they do not feel a lack of power in their lives. This study implemented elements of a quantitative design but a majority utilized a qualitative design based on the assumptions of the Interpretivist paradigm. The quantitative design elements focused on the analysis of two questionnaires: Sports Questionnaire and the Perceived Control Scale Questionnaire. The analysis of the focus group data revealed the following themes as positive effects of the intervention: positive effect on empowerment, how happy the program made the students, what benefits the students gained from the program, the student’s familiarity with university students, and the environment, and, lastly, the students ability to ask for assistance when need. Findings from the study determined that the empowerment of the students with disabilities was impacted while participating in the program. In general, the findings of gaining empowerment were similar to previous studies in that students with disabilities are able to gain empowerment from participation in fitness and recreation programs. The researcher noted during focus groups that some of the Best of Both Worlds (BOBW) students were not confident in starting conversations with their university peers. Although the BOBW students felt a sense of losing empowerment with this specific instance, there was an overall positive impact on the BOBW students

  19. Immigration and adult transitions.

    PubMed

    Rumbaut, Rubén G; Komaie, Golnaz

    2010-01-01

    Almost 30 percent of the more than 68 million young adults aged eighteen to thirty-four in the United States today are either foreign born or of foreign parentage. As these newcomers make their transitions to adulthood, say Rubén Rumbaut and Golnaz Komaie, they differ significantly not only from one another but also from their native-parentage counterparts, including blacks and whites. The authors document the demographic changes in the United States over the past forty years and describe the ways in which generation and national origin shape the experiences of these newcomers as they become adults. Rumbaut and Komaie point out that immigrant groups experience gaps in social, economic, and legal status that are even greater than the gaps between native whites and blacks. By far the most-educated (Indians) and the least-educated (Mexicans) groups in the United States today are first-generation immigrants, as are the groups with the lowest poverty rate (Filipinos) and the highest poverty rate (Dominicans). These social and economic divides reflect three very different ways immigrants enter the country: through regular immigration channels, without legal authorization, or as state-sponsored refugees. For many ethnic groups, significant progress takes place from the first to the second generation. But, say the authors, for millions of young immigrants, a lack of legal permanent residency status blocks their prospects for social mobility. Having an undocumented status has become all the more consequential with the failure of Congress to pass comprehensive federal immigration reforms. In the coming two decades, as the U.S. native-parentage labor force continues to shrink, immigrants and their children are expected to account for most of the growth of the nation's labor force, with the fastest-growing occupations requiring college degrees. Rumbaut and Komaie stress that one key to the nation's future will be how it incorporates young adults of immigrant origin in its

  20. Empowering Students in Transition.

    PubMed

    Sullivan, Ann-Catherine

    2016-01-01

    The purpose of this study was to (a) identify potential benefits for students with disabilities taking part in a physical activity program with same-age typical peers on a Midwest university campus and (b) to determine if the program impacted the students with disabilities empowerment. Empowerment theory was used to determine how transition students' attitudes change over the course of the semester while participating in a workout buddy program with same-age college peers. The program was structured to provide a sense of empowerment to students to make their own decisions and learn for themselves so they do not feel a lack of power in their lives. This study implemented elements of a quantitative design but a majority utilized a qualitative design based on the assumptions of the Interpretivist paradigm. The quantitative design elements focused on the analysis of two questionnaires: Sports Questionnaire and the Perceived Control Scale Questionnaire. The analysis of the focus group data revealed the following themes as positive effects of the intervention: positive effect on empowerment, how happy the program made the students, what benefits the students gained from the program, the student's familiarity with university students, and the environment, and, lastly, the students ability to ask for assistance when need. Findings from the study determined that the empowerment of the students with disabilities was impacted while participating in the program. In general, the findings of gaining empowerment were similar to previous studies in that students with disabilities are able to gain empowerment from participation in fitness and recreation programs. The researcher noted during focus groups that some of the Best of Both Worlds (BOBW) students were not confident in starting conversations with their university peers. Although the BOBW students felt a sense of losing empowerment with this specific instance, there was an overall positive impact on the BOBW students

  1. Stochastic Optimal Control via Bellman's Principle

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G.; Sun, Jian Q.

    2003-01-01

    This paper presents a method for finding optimal controls of nonlinear systems subject to random excitations. The method is capable to generate global control solutions when state and control constraints are present. The solution is global in the sense that controls for all initial conditions in a region of the state space are obtained. The approach is based on Bellman's Principle of optimality, the Gaussian closure and the Short-time Gaussian approximation. Examples include a system with a state-dependent diffusion term, a system in which the infinite hierarchy of moment equations cannot be analytically closed, and an impact system with a elastic boundary. The uncontrolled and controlled dynamics are studied by creating a Markov chain with a control dependent transition probability matrix via the Generalized Cell Mapping method. In this fashion, both the transient and stationary controlled responses are evaluated. The results show excellent control performances.

  2. Hybrid percolation transition in complex networks

    NASA Astrophysics Data System (ADS)

    Kahng, Byungnam

    Percolation has been one of the most applied statistical models. Percolation transition is one of the most robust continuous transitions known thus far. However, recent extensive researches reveal that it exhibits diverse types of phase transitions such as discontinuous and hybrid phase transitions. Here hybrid phase transition means the phase transition exhibiting natures of both continuous and discontinuous phase transitions simultaneously. Examples include k-core percolation, cascading failures in interdependent networks, synchronization, etc. Thus far, it is not manifest if the critical behavior of hybrid percolation transitions conforms to the conventional scaling laws of second-order phase transition. Here, we investigate the critical behaviors of hybrid percolation transitions in the cascading failure model in inter-dependent networks and the restricted Erdos-Renyi model. We find that the critical behaviors of the hybrid percolation transitions contain some features that cannot be described by the conventional theory of second-order percolation transitions.

  3. Security Sector Reform: A Case Study Approach to Transition and Capacity Building

    DTIC Science & Technology

    2010-01-01

    African Unity in Cotonou , Benin, and agreed on a ceasefire effective on August 1, 1993, as well as the establishment of a National Transitional...Observer Mission in Liberia (UNOMIL), which augmented ECOMOG in implementing the Cotonou Agreement. UNOMIL’s initial mandate included both a...transitional government, comprised of the three warring parties, to prepare for general elections. 50 Despite the optimism surrounding Cotonou , an uneasy

  4. ISS Update: Transit of Venus

    NASA Video Gallery

    ISS Update commentator Brandi Dean interviews Mario Runco, NASA astronaut, about Venus's transit across the sun on June 5, 2012. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #...

  5. Magnetic fields from phase transitions

    NASA Astrophysics Data System (ADS)

    Hindmarsh, Mark; Everett, Allen

    1998-11-01

    The generation of primordial magnetic fields from cosmological phase transitions is discussed, paying particular attention to the electroweak transition and to the various definitions of the ``average'' field that have been put forward. It is emphasized that only the volume average has dynamical significance as a seed for galactic dynamos. On rather general grounds of causality and energy conservation, it is shown that, in the absence of MHD effects that transfer power in the magnetic field from small to large scales, processes occurring at the electroweak transition cannot generate fields stronger than 10-20 G on a scale of 0.5 Mpc. However, it is implausible that this upper bound could ever be reached, as it would require all the energy in the Universe to be turned into a magnetic field coherent at the horizon scale. Non-linear MHD effects seem therefore to be necessary if the electroweak transition is to create a primordial seed field.

  6. Moved by a Rapid Transit

    NASA Astrophysics Data System (ADS)

    Bueter, C.

    2013-04-01

    Enticing by virtue of its predictability, historical utility, and spectacle, the transit of Venus is a niche event among astronomical phenomena. Though the value of a transit for scientific purposes is now diminished, the brief appearance of Venus silhouetted against the background of the Sun in 2004 moved the artistic community to celebrate the rare alignment. Artists of all ages combined old traditions with fresh technology to create a 21st-century tapestry of music, sculpture, paintings, glasswork, quilts, sky shows, and digital imagery. A full catalog of transit-related art generated over the centuries would feature the sampling of entries presented here and at the Moved by a Rapid Transit website.

  7. Strong dependence of fluorescence quenching on the transition metal in layered transition metal dichalcogenide nanoflakes for nucleic acid detection.

    PubMed

    Loo, Adeline Huiling; Bonanni, Alessandra; Pumera, Martin

    2016-08-07

    In recent years, the application of transition metal dichalcogenides for the development of biosensors has been receiving widespread attention from researchers, as demonstrated by the surge in studies present in the field. While different transition metal dichalcogenide materials have been employed for the fabrication of fluorescent biosensors with superior performance, no research has been conducted to draw comparisons across materials containing different transition metals. Herein, the performance of MoS2 and WS2 nanoflakes for the fluorescence detection of nucleic acids is assessed. It is discovered that, at the optimal amount, MoS2 and WS2 nanoflakes exhibit a similar degree of fluorescence quenching, at 75% and 71% respectively. However, MoS2 nanoflakes have better performance in the areas of detection range and selectivity than WS2 nanoflakes. The detection range achieved with MoS2 nanoflakes is 9.60-366 nM while 13.3-143 nM with WS2 nanoflakes. In the context of selectivity, MoS2 nanoflakes display a signal difference of 97.8% between complementary and non-complementary DNA targets, whereas WS2 nanoflakes only exhibit 44.3%. Such research is highly beneficial as it delivers vital insights on how the performance of a fluorescent biosensor can be affected by the transition metal present. Furthermore, these insights can assist in the selection of suitable transition metal dichalcogenide materials for utilization in biosensor development.

  8. Phase Transitions in Brownian Pumps

    NASA Astrophysics Data System (ADS)

    Dierl, Marcel; Dieterich, Wolfgang; Einax, Mario; Maass, Philipp

    2014-04-01

    We study stochastic particle transport between two reservoirs along a channel, where the particles are pumped against a bias by a traveling wave potential. It is shown that phase transitions of period-averaged densities or currents occur inside the channel when exclusion interactions between the particles are taken into account. These transitions reflect those known for the asymmetric simple exclusion process. We argue that their occurrence is a generic feature of Brownian motors operating in open systems.

  9. Universal Keplerian state transition matrix

    NASA Technical Reports Server (NTRS)

    Shepperd, S. W.

    1985-01-01

    A completely general method for computing the Keplerian state transition matrix in terms of Goodyear's universal variables is presented. This includes a new scheme for solving Kepler's problem which is a necessary first step to computing the transition matrix. The Kepler problem is solved in terms of a new independent variable requiring the evaluation of only one transcendental function. Furthermore, this transcendental function may be conveniently evaluated by means of a Gaussian continued fraction.

  10. Optimal quantum pumps.

    PubMed

    Avron, J E; Elgart, A; Graf, G M; Sadun, L

    2001-12-03

    We study adiabatic quantum pumps on time scales that are short relative to the cycle of the pump. In this regime the pump is characterized by the matrix of energy shift which we introduce as the dual to Wigner's time delay. The energy shift determines the charge transport, the dissipation, the noise, and the entropy production. We prove a general lower bound on dissipation in a quantum channel and define optimal pumps as those that saturate the bound. We give a geometric characterization of optimal pumps and show that they are noiseless and transport integral charge in a cycle. Finally we discuss an example of an optimal pump related to the Hall effect.

  11. Optimal control computer programs

    NASA Technical Reports Server (NTRS)

    Kuo, F.

    1992-01-01

    The solution of the optimal control problem, even with low order dynamical systems, can usually strain the analytical ability of most engineers. The understanding of this subject matter, therefore, would be greatly enhanced if a software package existed that could simulate simple generic problems. Surprisingly, despite a great abundance of commercially available control software, few, if any, address the part of optimal control in its most generic form. The purpose of this paper is, therefore, to present a simple computer program that will perform simulations of optimal control problems that arise from the first necessary condition and the Pontryagin's maximum principle.

  12. Optimal Linear Control.

    DTIC Science & Technology

    1979-12-01

    OPTIMAL LINEAR CONTROL C.A. HARVEY M.G. SAFO NOV G. STEIN J.C. DOYLE HONEYWELL SYSTEMS & RESEARCH CENTER j 2600 RIDGWAY PARKWAY j [ MINNEAPOLIS...RECIPIENT’S CAT ALC-’ W.IMIJUff’? * J~’ CR2 15-238-4F TP P EI)ŕll * (~ Optimal Linear Control ~iOGRPR UBA m a M.G Lnar o Con_ _ _ _ _ _ R PORT__ _ _ I RE...Characterizations of optimal linear controls have been derived, from which guides for selecting the structure of the control system and the weights in

  13. Contingency contractor optimization.

    SciTech Connect

    Gearhart, Jared Lee; Adair, Kristin Lynn; Jones, Katherine A.; Bandlow, Alisa; Detry, Richard Joseph; Durfee, Justin David.; Jones, Dean A.; Martin, Nathaniel; Nanco, Alan Stewart; Nozick, Linda Karen

    2013-06-01

    The goal of Phase 3 the OSD ATL Contingency Contractor Optimization (CCO) project is to create an engineering prototype of a tool for the contingency contractor element of total force planning during the Support for Strategic Analysis (SSA). An optimization model was developed to determine the optimal mix of military, Department of Defense (DoD) civilians, and contractors that accomplishes a set of user defined mission requirements at the lowest possible cost while honoring resource limitations and manpower use rules. An additional feature allows the model to understand the variability of the Total Force Mix when there is uncertainty in mission requirements.

  14. Contingency contractor optimization.

    SciTech Connect

    Gearhart, Jared Lee; Adair, Kristin Lynn; Jones, Katherine A.; Bandlow, Alisa; Durfee, Justin David.; Jones, Dean A.; Martin, Nathaniel; Detry, Richard Joseph; Nanco, Alan Stewart; Nozick, Linda Karen

    2013-10-01

    The goal of Phase 3 the OSD ATL Contingency Contractor Optimization (CCO) project is to create an engineering prototype of a tool for the contingency contractor element of total force planning during the Support for Strategic Analysis (SSA). An optimization model was developed to determine the optimal mix of military, Department of Defense (DoD) civilians, and contractors that accomplishes a set of user defined mission requirements at the lowest possible cost while honoring resource limitations and manpower use rules. An additional feature allows the model to understand the variability of the Total Force Mix when there is uncertainty in mission requirements.

  15. Rapid Optimization Library

    SciTech Connect

    Denis Rldzal, Drew Kouri

    2014-05-13

    ROL provides interfaces to and implementations of algorithms for gradient-based unconstrained and constrained optimization. ROL can be used to optimize the response of any client simulation code that evaluates scalar-valued response functions. If the client code can provide gradient information for the response function, ROL will take advantage of it, resulting in faster runtimes. ROL's interfaces are matrix-free, in other words ROL only uses evaluations of scalar-valued and vector-valued functions. ROL can be used to solve optimal design problems and inverse problems based on a variety of simulation software.

  16. Markers of Endothelial-to-Mesenchymal Transition: Evidence for Antibody-Endothelium Interaction during Antibody-Mediated Rejection in Kidney Recipients.

    PubMed

    Xu-Dubois, Yi-Chun; Peltier, Julie; Brocheriou, Isabelle; Suberbielle-Boissel, Caroline; Djamali, Arjang; Reese, Shannon; Mooney, Nuala; Keuylian, Zela; Lion, Julien; Ouali, Nacéra; Levy, Pierre P; Jouanneau, Chantal; Rondeau, Eric; Hertig, Alexandre

    2016-01-01

    Antibody-mediated rejection (ABMR) is a leading cause of allograft loss. Treatment efficacy depends on accurate diagnosis at an early stage. However, sensitive and reliable markers of antibody-endothelium interaction during ABMR are not available for routine use. Using immunohistochemistry, we retrospectively studied the diagnostic value of three markers of endothelial-to-mesenchymal transition (EndMT), fascin1, vimentin, and heat shock protein 47, for ABMR in 53 renal transplant biopsy specimens, including 20 ABMR specimens, 24 cell-mediated rejection specimens, and nine normal grafts. We validated our results in an independent set of 74 unselected biopsy specimens. Endothelial cells of the peritubular capillaries in grafts with ABMR expressed fascin1, vimentin, and heat shock protein 47 strongly, whereas those from normal renal grafts did not. The level of EndMT marker expression was significantly associated with current ABMR criteria, including capillaritis, glomerulitis, peritubular capillary C4d deposition, and donor-specific antibodies. These markers allowed us to identify C4d-negative ABMR and to predict late occurrence of disease. EndMT markers were more specific than capillaritis for the diagnosis and prognosis of ABMR and predicted late (up to 4 years after biopsy) renal graft dysfunction and proteinuria. In the independent set of 74 renal graft biopsy specimens, the EndMT markers for the diagnosis of ABMR had a sensitivity of 100% and a specificity of 85%. Fascin1 expression in peritubular capillaries was also induced in a rat model of ABMR. In conclusion, EndMT markers are a sensitive and reliable diagnostic tool for detecting endothelial activation during ABMR and predicting late loss of allograft function.

  17. Boundary layer transition studies

    NASA Technical Reports Server (NTRS)

    Watmuff, Jonathan H.

    1995-01-01

    A small-scale wind tunnel previously used for turbulent boundary layer experiments was modified for two sets of boundary layer transition studies. The first study concerns a laminar separation/turbulent reattachment. The pressure gradient and unit Reynolds number are the same as the fully turbulent flow of Spalart and Watmuff. Without the trip wire, a laminar layer asymptotes to a Falkner & Skan similarity solution in the FPG. Application of the APG causes the layer to separate and a highly turbulent and approximately 2D mean flow reattachment occurs downstream. In an effort to gain some physical insight into the flow processes a small impulsive disturbance was introduced at the C(sub p) minimum. The facility is totally automated and phase-averaged data are measured on a point-by-point basis using unprecedently large grids. The evolution of the disturbance has been tracked all the way into the reattachment region and beyond into the fully turbulent boundary layer. At first, the amplitude decays exponentially with streamwise distance in the APG region, where the layer remains attached, i.e. the layer is viscously stable. After separation, the rate of decay slows, and a point of minimum amplitude is reached where the contours of the wave packet exhibit dispersive characteristics. From this point, exponential growth of the amplitude of the disturbance is observed in the detached shear layer, i.e. the dominant instability mechanism is inviscid. A group of large-scale 3D vortex loops emerges in the vicinity of the reattachment. Remarkably, the second loop retains its identify far downstream in the turbulent boundary layer. The results provide a level of detail usually associated with CFD. Substantial modifications were made to the facility for the second study concerning disturbances generated by Suction Holes for laminar flow Control (LFC). The test section incorporates suction through interchangeable porous test surfaces. Detailed studies have been made using isolated

  18. Boundary layer transition studies

    NASA Astrophysics Data System (ADS)

    Watmuff, Jonathan H.

    1995-02-01

    A small-scale wind tunnel previously used for turbulent boundary layer experiments was modified for two sets of boundary layer transition studies. The first study concerns a laminar separation/turbulent reattachment. The pressure gradient and unit Reynolds number are the same as the fully turbulent flow of Spalart and Watmuff. Without the trip wire, a laminar layer asymptotes to a Falkner & Skan similarity solution in the FPG. Application of the APG causes the layer to separate and a highly turbulent and approximately 2D mean flow reattachment occurs downstream. In an effort to gain some physical insight into the flow processes a small impulsive disturbance was introduced at the C(sub p) minimum. The facility is totally automated and phase-averaged data are measured on a point-by-point basis using unprecedently large grids. The evolution of the disturbance has been tracked all the way into the reattachment region and beyond into the fully turbulent boundary layer. At first, the amplitude decays exponentially with streamwise distance in the APG region, where the layer remains attached, i.e. the layer is viscously stable. After separation, the rate of decay slows, and a point of minimum amplitude is reached where the contours of the wave packet exhibit dispersive characteristics. From this point, exponential growth of the amplitude of the disturbance is observed in the detached shear layer, i.e. the dominant instability mechanism is inviscid. A group of large-scale 3D vortex loops emerges in the vicinity of the reattachment. Remarkably, the second loop retains its identify far downstream in the turbulent boundary layer. The results provide a level of detail usually associated with CFD. Substantial modifications were made to the facility for the second study concerning disturbances generated by Suction Holes for laminar flow Control (LFC). The test section incorporates suction through interchangeable porous test surfaces. Detailed studies have been made using isolated

  19. Numerical optimization of conical flow waveriders including detailed viscous effects

    NASA Technical Reports Server (NTRS)

    Bowcutt, Kevin G.; Anderson, John D., Jr.; Capriotti, Diego

    1987-01-01

    A family of optimized hypersonic waveriders is generated and studied wherein detailed viscous effects are included within the optimization process itself. This is in contrast to previous optimized waverider work, wherein purely inviscid flow is used to obtain the waverider shapes. For the present waveriders, the undersurface is a streamsurface of an inviscid conical flowfield, the upper surface is a streamsurface of the inviscid flow over a tapered cylinder (calculated by the axisymmetric method of characteristics), and the viscous effects are treated by integral solutions of the boundary layer equations. Transition from laminar to turbulent flow is included within the viscous calculations. The optimization is carried out using a nonlinear simplex method. The resulting family of viscous hypersonic waveriders yields predicted high values of lift/drag, high enough to break the L/D barrier based on experience with other hypersonic configurations. Moreover, the numerical optimization process for the viscous waveriders results in distinctly different shapes compared to previous work with inviscid-designed waveriders. Also, the fine details of the viscous solution, such as how the shear stress is distributed over the surface, and the location of transition, are crucial to the details of the resulting waverider geometry. Finally, the moment coefficient variations and heat transfer distributions associated with the viscous optimized waveriders are studied.

  20. Computational analysis of flow in 3D propulsive transition ducts

    NASA Technical Reports Server (NTRS)

    Sepri, Paavo

    1990-01-01

    A numerical analysis of fully three dimensional, statistically steady flows in propulsive transition ducts being considered for use in future aircraft of higher maneuverability is investigated. The purpose of the transition duct is to convert axisymmetric flow from conventional propulsion systems to that of a rectangular geometry of high aspect ratio. In an optimal design, the transition duct would be of minimal length in order to reduce the weight penalty, while the geometrical change would be gradual enough to avoid detrimental flow perturbations. Recent experiments conducted at the Propulsion Aerodynamics Branch have indicated that thrust losses in ducts of superelliptic cross-section can be surprisingly low, even if flow separation occurs near the divergent walls. In order to address the objective of developing a rational design procedure for optimal transition ducts, it is necessary to have available a reliable computational tool for the analysis of flows achieved in a sequence of configurations. Current CFD efforts involving complicated geometries usually must contend with two separate but interactive aspects: namely, grid generation and flow solution. The first two avenues of the present investigation were comprised of suitable grid generation for a class of transition ducts of superelliptic cross-section, and the subsequent application of the flow solver PAB3D to this geometry. The code, PAB3D, was developed as a comprehensive tool for the solution of both internal and external high speed flows. The third avenue of investigation has involved analytical formulations to aid in the understanding of the nature of duct flows, and also to provide a basis of comparison for subsequent numerical solutions. Numerical results to date include the generation of two preliminary grid systems for duct flows, and the initial application of PAB3D to the corresponding geometries, which are of the class tested experimentally.

  1. Deducing the Kinetics of Protein Synthesis In Vivo from the Transition Rates Measured In Vitro

    PubMed Central

    Rudorf, Sophia; Thommen, Michael; Rodnina, Marina V.; Lipowsky, Reinhard

    2014-01-01

    The molecular machinery of life relies on complex multistep processes that involve numerous individual transitions, such as molecular association and dissociation steps, chemical reactions, and mechanical movements. The corresponding transition rates can be typically measured in vitro but not in vivo. Here, we develop a general method to deduce the in-vivo rates from their in-vitro values. The method has two basic components. First, we introduce the kinetic distance, a new concept by which we can quantitatively compare the kinetics of a multistep process in different environments. The kinetic distance depends logarithmically on the transition rates and can be interpreted in terms of the underlying free energy barriers. Second, we minimize the kinetic distance between the in-vitro and the in-vivo process, imposing the constraint that the deduced rates reproduce a known global property such as the overall in-vivo speed. In order to demonstrate the predictive power of our method, we apply it to protein synthesis by ribosomes, a key process of gene expression. We describe the latter process by a codon-specific Markov model with three reaction pathways, corresponding to the initial binding of cognate, near-cognate, and non-cognate tRNA, for which we determine all individual transition rates in vitro. We then predict the in-vivo rates by the constrained minimization procedure and validate these rates by three independent sets of in-vivo data, obtained for codon-dependent translation speeds, codon-specific translation dynamics, and missense error frequencies. In all cases, we find good agreement between theory and experiment without adjusting any fit parameter. The deduced in-vivo rates lead to smaller error frequencies than the known in-vitro rates, primarily by an improved initial selection of tRNA. The method introduced here is relatively simple from a computational point of view and can be applied to any biomolecular process, for which we have detailed information

  2. RF Gun Optimization Study

    SciTech Connect

    Alicia Hofler; Pavel Evtushenko

    2007-07-03

    Injector gun design is an iterative process where the designer optimizes a few nonlinearly interdependent beam parameters to achieve the required beam quality for a particle accelerator. Few tools exist to automate the optimization process and thoroughly explore the parameter space. The challenging beam requirements of new accelerator applications such as light sources and electron cooling devices drive the development of RF and SRF photo injectors. A genetic algorithm (GA) has been successfully used to optimize DC photo injector designs at Cornell University [1] and Jefferson Lab [2]. We propose to apply GA techniques to the design of RF and SRF gun injectors. In this paper, we report on the initial phase of the study where we model and optimize a system that has been benchmarked with beam measurements and simulation.

  3. Flyby Geometry Optimization Tool

    NASA Technical Reports Server (NTRS)

    Karlgaard, Christopher D.

    2007-01-01

    The Flyby Geometry Optimization Tool is a computer program for computing trajectories and trajectory-altering impulsive maneuvers for spacecraft used in radio relay of scientific data to Earth from an exploratory airplane flying in the atmosphere of Mars.

  4. Optimizing influenza vaccine distribution.

    PubMed

    Medlock, Jan; Galvani, Alison P

    2009-09-25

    The criteria to assess public health policies are fundamental to policy optimization. Using a model parametrized with survey-based contact data and mortality data from influenza pandemics, we determined optimal vaccine allocation for five outcome measures: deaths, infections, years of life lost, contingent valuation, and economic costs. We find that optimal vaccination is achieved by prioritization of schoolchildren and adults aged 30 to 39 years. Schoolchildren are most responsible for transmission, and their parents serve as bridges to the rest of the population. Our results indicate that consideration of age-specific transmission dynamics is paramount to the optimal allocation of influenza vaccines. We also found that previous and new recommendations from the U.S. Centers for Disease Control and Prevention both for the novel swine-origin influenza and, particularly, for seasonal influenza, are suboptimal for all outcome measures.

  5. General shape optimization capability

    NASA Technical Reports Server (NTRS)

    Chargin, Mladen K.; Raasch, Ingo; Bruns, Rudolf; Deuermeyer, Dawson

    1991-01-01

    A method is described for calculating shape sensitivities, within MSC/NASTRAN, in a simple manner without resort to external programs. The method uses natural design variables to define the shape changes in a given structure. Once the shape sensitivities are obtained, the shape optimization process is carried out in a manner similar to property optimization processes. The capability of this method is illustrated by two examples: the shape optimization of a cantilever beam with holes, loaded by a point load at the free end (with the shape of the holes and the thickness of the beam selected as the design variables), and the shape optimization of a connecting rod subjected to several different loading and boundary conditions.

  6. Transition boiling heat transfer and the film transition regime

    NASA Technical Reports Server (NTRS)

    Ramilison, J. M.; Lienhard, J. H.

    1987-01-01

    The Berenson (1960) flat-plate transition-boiling experiment has been recreated with a reduced thermal resistance in the heater, and an improved access to those portions of the transition boiling regime that have a steep negative slope. Tests have been made in Freon-113, acetone, benzene, and n-pentane boiling on horizontal flat copper heaters that have been mirror-polished, 'roughened', or teflon-coated. The resulting data reproduce and clarify certain features observed by Berenson: the modest surface finish dependence of boiling burnout, and the influence of surface chemistry on both the minimum heat flux and the mode of transition boiling, for example. A rational scheme of correlation yields a prediction of the heat flux in what Witte and Lienhard (1982) previously identified as the 'film-transition boiling' region. It is also shown how to calculate the heat flux at the boundary between the pure-film, and the film-transition, boiling regimes, as a function of the advancing contact angle.

  7. Depth Optimization Study

    DOE Data Explorer

    Kawase, Mitsuhiro

    2009-11-22

    The zipped file contains a directory of data and routines used in the NNMREC turbine depth optimization study (Kawase et al., 2011), and calculation results thereof. For further info, please contact Mitsuhiro Kawase at kawase@uw.edu. Reference: Mitsuhiro Kawase, Patricia Beba, and Brian Fabien (2011), Finding an Optimal Placement Depth for a Tidal In-Stream Conversion Device in an Energetic, Baroclinic Tidal Channel, NNMREC Technical Report.

  8. Optimized Bolted Joint

    NASA Technical Reports Server (NTRS)

    Hart-Smith, L. J.; Bunin, B. L.; Watts, D. J.

    1986-01-01

    Computer technique aids joint optimization. Load-sharing between fasteners in multirow bolted composite joints computed by nonlinear-analysis computer program. Input to analysis was load-deflection data from 180 specimens tested as part of program to develop technology of structural joints for advanced transport aircraft. Bolt design optimization technique applicable to major joints in composite materials for primary and secondary structures and generally applicable for metal joints as well.

  9. Optimization Of Simulated Trajectories

    NASA Technical Reports Server (NTRS)

    Brauer, Garry L.; Olson, David W.; Stevenson, Robert

    1989-01-01

    Program To Optimize Simulated Trajectories (POST) provides ability to target and optimize trajectories of point-mass powered or unpowered vehicle operating at or near rotating planet. Used successfully to solve wide variety of problems in mechanics of atmospheric flight and transfer between orbits. Generality of program demonstrated by its capability to simulate up to 900 distinct trajectory phases, including generalized models of planets and vehicles. VAX version written in FORTRAN 77 and CDC version in FORTRAN V.

  10. Modeling using optimization routines

    NASA Technical Reports Server (NTRS)

    Thomas, Theodore

    1995-01-01

    Modeling using mathematical optimization dynamics is a design tool used in magnetic suspension system development. MATLAB (software) is used to calculate minimum cost and other desired constraints. The parameters to be measured are programmed into mathematical equations. MATLAB will calculate answers for each set of inputs; inputs cover the boundary limits of the design. A Magnetic Suspension System using Electromagnets Mounted in a Plannar Array is a design system that makes use of optimization modeling.

  11. Introduction: optimization in networks.

    PubMed

    Motter, Adilson E; Toroczkai, Zoltan

    2007-06-01

    The recent surge in the network modeling of complex systems has set the stage for a new era in the study of fundamental and applied aspects of optimization in collective behavior. This Focus Issue presents an extended view of the state of the art in this field and includes articles from a large variety of domains in which optimization manifests itself, including physical, biological, social, and technological networked systems.

  12. Optimizing homogenization by chaotic unmixing?

    NASA Astrophysics Data System (ADS)

    Weijs, Joost; Bartolo, Denis

    2016-11-01

    A number of industrial processes rely on the homogeneous dispersion of non-brownian particles in a viscous fluid. An ideal mixing would yield a so-called hyperuniform particle distribution. Such configurations are characterized by density fluctuations that grow slower than the standard √{ N}-fluctuations. Even though such distributions have been found in several natural structures, e.g. retina receptors in birds, they have remained out of experimental reach until very recently. Over the last 5 years independent experiments and numerical simulations have shown that periodically driven suspensions can self-assemble hyperuniformally. Simple as the recipe may be, it has one important disadvantage. The emergence of hyperuniform states co-occurs with a critical phase transition from reversible to non reversible particle dynamics. As a consequence the homogenization dynamics occurs over a time that diverges with the system size (critical slowing down). Here, we discuss how this process can be sped up by exploiting the stirring properties of chaotic advection. Among the questions that we answer are: What are the physical mechanisms in a chaotic flow that are relevant for hyperuniformity? How can we tune the flow parameters such to obtain optimal hyperuniformity in the fastest way? JW acknowledges funding by NWO (Netherlands Organisation for Scientific Research) through a Rubicon Grant.

  13. Cyclone performance and optimization

    SciTech Connect

    Leith, D.

    1990-09-15

    The objectives of this project are: to characterize the gas flow pattern within cyclones, to revise the theory for cyclone performance on the basis of these findings, and to design and test cyclones whose dimensions have been optimized using revised performance theory. This work is important because its successful completion will aid in the technology for combustion of coal in pressurized, fluidized beds. This quarter, an empirical model for predicting pressure drop across a cyclone was developed through a statistical analysis of pressure drop data for 98 cyclone designs. The model is shown to perform better than the pressure drop models of First (1950), Alexander (1949), Barth (1956), Stairmand (1949), and Shepherd-Lapple (1940). This model is used with the efficiency model of Iozia and Leith (1990) to develop an optimization curve which predicts the minimum pressure drop and the dimension rations of the optimized cyclone for a given aerodynamic cut diameter, d{sub 50}. The effect of variation in cyclone height, cyclone diameter, and flow on the optimization curve is determined. The optimization results are used to develop a design procedure for optimized cyclones. 37 refs., 10 figs., 4 tabs.

  14. Regularizing portfolio optimization

    NASA Astrophysics Data System (ADS)

    Still, Susanne; Kondor, Imre

    2010-07-01

    The optimization of large portfolios displays an inherent instability due to estimation error. This poses a fundamental problem, because solutions that are not stable under sample fluctuations may look optimal for a given sample, but are, in effect, very far from optimal with respect to the average risk. In this paper, we approach the problem from the point of view of statistical learning theory. The occurrence of the instability is intimately related to over-fitting, which can be avoided using known regularization methods. We show how regularized portfolio optimization with the expected shortfall as a risk measure is related to support vector regression. The budget constraint dictates a modification. We present the resulting optimization problem and discuss the solution. The L2 norm of the weight vector is used as a regularizer, which corresponds to a diversification 'pressure'. This means that diversification, besides counteracting downward fluctuations in some assets by upward fluctuations in others, is also crucial because it improves the stability of the solution. The approach we provide here allows for the simultaneous treatment of optimization and diversification in one framework that enables the investor to trade off between the two, depending on the size of the available dataset.

  15. Training a quantum optimizer

    NASA Astrophysics Data System (ADS)

    Wecker, Dave; Hastings, Matthew B.; Troyer, Matthias

    2016-08-01

    We study a variant of the quantum approximate optimization algorithm [E. Farhi, J. Goldstone, and S. Gutmann, arXiv:1411.4028] with a slightly different parametrization and a different objective: rather than looking for a state which approximately solves an optimization problem, our goal is to find a quantum algorithm that, given an instance of the maximum 2-satisfiability problem (MAX-2-SAT), will produce a state with high overlap with the optimal state. Using a machine learning approach, we chose a "training set" of instances and optimized the parameters to produce a large overlap for the training set. We then tested these optimized parameters on a larger instance set. As a training set, we used a subset of the hard instances studied by Crosson, Farhi, C. Y.-Y. Lin, H.-H. Lin, and P. Shor (CFLLS) (arXiv:1401.7320). When tested, on the full set, the parameters that we find produce a significantly larger overlap than the optimized annealing times of CFLLS. Testing on other random instances from 20 to 28 bits continues to show improvement over annealing, with the improvement being most notable on the hardest instances. Further tests on instances of MAX-3-SAT also showed improvement on the hardest instances. This algorithm may be a possible application for near-term quantum computers with limited coherence times.

  16. Role of Transitional Care Measures in the Prevention of Readmission After Critical Illness.

    PubMed

    Peters, Jessica S

    2017-02-01

    Transitioning from the critical care unit to the medical-surgical care area is vital to patients' recovery and resolution of critical illness. Such transitions are necessary to optimize use of available hospital resources to meet patient care needs. One in 10 patients discharged from the intensive care unit are readmitted to the unit during their hospitalization. Critical care readmission is associated with significant increases in illness acuity, overall length of stay, and health care costs as well as a potential 4-fold increased risk of mortality. Patients with complex illness, multiple comorbid conditions, and a prolonged initial stay in the critical care unit are at an increased risk of being readmitted to the critical care unit and experiencing poor outcomes. Implementing nurse-driven measures that support continuity of care and consistent communication practices such as critical care outreach services, transitional communication tools, discharge planning, and transitional care units improves transitions of patients from the critical care environment and reduces readmission rates.

  17. Physical implication of transition voltage in organic nano-floating-gate nonvolatile memories

    NASA Astrophysics Data System (ADS)

    Wang, Shun; Gao, Xu; Zhong, Ya-Nan; Zhang, Zhong-Da; Xu, Jian-Long; Wang, Sui-Dong

    2016-07-01

    High-performance pentacene-based organic field-effect transistor nonvolatile memories, using polystyrene as a tunneling dielectric and Au nanoparticles as a nano-floating-gate, show parallelogram-like transfer characteristics with a featured transition point. The transition voltage at the transition point corresponds to a threshold electric field in the tunneling dielectric, over which stored electrons in the nano-floating-gate will start to leak out. The transition voltage can be modulated depending on the bias configuration and device structure. For p-type active layers, optimized transition voltage should be on the negative side of but close to the reading voltage, which can simultaneously achieve a high ON/OFF ratio and good memory retention.

  18. Alternative method to characterize continuous and discontinuous phase transitions in surface reaction models.

    PubMed

    Fernandes, Henrique A; da Silva, Roberto; Santos, Eder D; Gomes, Paulo F; Arashiro, Everaldo

    2016-08-01

    In this paper we revisited the Ziff-Gulari-Barshad model to study its phase transitions and critical exponents through time-dependent Monte Carlo simulations. We use a method proposed recently to locate the nonequilibrium second-order phase transitions and that has been successfully used in systems with defined Hamiltonians and with absorbing states. This method, which is based on optimization of the coefficient of determination of the order parameter, was able to characterize the continuous phase transition of the model, as well as its upper spinodal point, a pseudocritical point located near the discontinuous phase transition. The static critical exponents β, ν_{∥}, and ν_{⊥}, as well as the dynamic critical exponents θ and z for the continuous transition point, were also estimated and are in excellent agreement with results found in literature.

  19. Phase transitions of the random-bond Potts chain with long-range interactions

    NASA Astrophysics Data System (ADS)

    Anglès d'Auriac, Jean-Christian; Iglói, Ferenc

    2016-12-01

    We study phase transitions of the ferromagnetic q -state Potts chain with random nearest-neighbor couplings having a variance Δ2 and with homogeneous long-range interactions, which decay with distance as a power r-(1 +σ ), σ >0 . In the large-q limit the free-energy of random samples of length L ≤2048 is calculated exactly by a combinatorial optimization algorithm. The phase transition stays first order for σ <σc(Δ ) ≤0.5 , while the correlation length becomes divergent at the transition point for σc(Δ ) <σ <1 . In the latter regime the average magnetization is continuous for small enough Δ , but for larger Δ —according to the numerical results—it becomes discontinuous at the transition point, thus the phase transition is expected of mixed order.

  20. GATE (Gaia Transiting Exoplanets): Detecting Transiting Exoplanets with Gaia

    NASA Astrophysics Data System (ADS)

    Zucker, Shay; Eyer, Laurent; Hodgkin, Simon; Clementini, Gisella

    2016-10-01

    Gaia will have a revolutionary impact on most fields of astronomy. However, its scanning law is too sparse for traditional transit detection approaches (de Bruijne 2012). Practically, only stars brighter than 16th magnitude are relevant for follow-up of transiting exoplanets. For those stars, Gaia's precision is of the order of 1 mmag (Eyer et al. 2015). On average, Gaia will have sampled each target 70 times, but certain stars may be observed as many as 200 times (Voss et al. 2013). Hipparcos scanning law was similar, but its precision much worse. Nevertheless the transit of HD209458 could be seen, aposteriori, in Hipparcos' data (Söderhelm 1999). This inspired our GATE initiative.

  1. Transitions of care in heart failure: a scientific statement from the American Heart Association.

    PubMed

    Albert, Nancy M; Barnason, Susan; Deswal, Anita; Hernandez, Adrian; Kociol, Robb; Lee, Eunyoung; Paul, Sara; Ryan, Catherine J; White-Williams, Connie

    2015-03-01

    In patients with heart failure (HF), use of 30-day rehospitalization as a healthcare metric and increased pressure to provide value-based care compel healthcare providers to improve efficiency and to use an integrated care approach. Transition programs are being used to achieve goals. Transition of care in the context of HF management refers to individual interventions and programs with multiple activities that are designed to improve shifts or transitions from one setting to the next, most often from hospital to home. As transitional care programs become the new normal for patients with chronic HF, it is important to understand the current state of the science of transitional care, as discussed in the available research literature. Of transitional care reports, there was much heterogeneity in research designs, methods, study aims, and program targets, or they were not well described. Often, programs used bundled interventions, making it difficult to discuss the efficiency and effectiveness of specific interventions. Thus, further HF transition care research is needed to ensure best practices related to economically and clinically effective and feasible transition interventions that can be broadly applicable. This statement provides an overview of the complexity of HF management and includes patient, hospital, and healthcare provider barriers to understanding end points that best reflect clinical benefits and to achieving optimal clinical outcomes. The statement describes transitional care interventions and outcomes and discusses implications and recommendations for research and clinical practice to enhance patient-centered outcomes.

  2. Regardless of age: Incorporating principles from geriatric medicine to improve care transitions for patients with complex needs.

    PubMed

    Arbaje, Alicia I; Kansagara, Devan L; Salanitro, Amanda H; Englander, Honora L; Kripalani, Sunil; Jencks, Stephen F; Lindquist, Lee A

    2014-06-01

    With its focus on holistic approaches to patient care, caregiver support, and delivery system redesign, geriatrics has advanced our understanding of optimal care during transitions. This article provides a framework for incorporating geriatrics principles into care transition activities by discussing the following elements: (1) identifying factors that make transitions more complex, (2) engaging care "receivers" and tailoring home care to meet patient needs, (3) building "recovery plans" into transitional care, (4) predicting and avoiding preventable readmissions, and (5) adopting a palliative approach, when appropriate, that optimizes patient and family goals of care. The article concludes with a discussion of practical aspects of designing, implementing, and evaluating care transitions programs for those with complex care needs, as well as implications for public policy.

  3. Finding Optimal Apertures in Kepler Data

    NASA Astrophysics Data System (ADS)

    Smith, Jeffrey C.; Morris, Robert L.; Jenkins, Jon M.; Bryson, Stephen T.; Caldwell, Douglas A.; Girouard, Forrest R.

    2016-12-01

    With the loss of two spacecraft reaction wheels precluding further data collection for the Kepler primary mission, even greater pressure is placed on the processing pipeline to eke out every last transit signal in the data. To that end, we have developed a new method to optimize the Kepler Simple Aperture Photometry (SAP) photometric apertures for both planet detection and minimization of systematic effects. The approach uses a per cadence modeling of the raw pixel data and then performs an aperture optimization based on signal-to-noise ratio and the Kepler Combined Differential Photometric Precision (CDPP), which is a measure of the noise over the duration of a reference transit signal. We have found the new apertures to be superior to the previous Kepler apertures. We can now also find a per cadence flux fraction in aperture and crowding metric. The new approach has also been proven to be robust at finding apertures in K2 data that help mitigate the larger motion-induced systematics in the photometry. The method further allows us to identify errors in the Kepler and K2 input catalogs.

  4. Reliable Transition State Searches Integrated with the Growing String Method.

    PubMed

    Zimmerman, Paul

    2013-07-09

    The growing string method (GSM) is highly useful for locating reaction paths connecting two molecular intermediates. GSM has often been used in a two-step procedure to locate exact transition states (TS), where GSM creates a quality initial structure for a local TS search. This procedure and others like it, however, do not always converge to the desired transition state because the local search is sensitive to the quality of the initial guess. This article describes an integrated technique for simultaneous reaction path and exact transition state search. This is achieved by implementing an eigenvector following optimization algorithm in internal coordinates with Hessian update techniques. After partial convergence of the string, an exact saddle point search begins under the constraint that the maximized eigenmode of the TS node Hessian has significant overlap with the string tangent near the TS. Subsequent optimization maintains connectivity of the string to the TS as well as locks in the TS direction, all but eliminating the possibility that the local search leads to the wrong TS. To verify the robustness of this approach, reaction paths and TSs are found for a benchmark set of more than 100 elementary reactions.

  5. Performance Assessment for Pump-and-Treat Closure or Transition

    SciTech Connect

    Truex, Michael J.; Johnson, Christian D.; Becker, Dave J.; Lee, Michelle H.; Nimmons, Michael J.

    2015-09-29

    A structured performance assessment approach is useful to evaluate pump-and-treat (P&T) groundwater remediation, which has been applied at numerous sites. Consistent with the U.S. Environmental Protection Agency’s Groundwater Road Map, performance assessment during remedy implementation may be needed, and should consider remedy optimization, transition to alternative remedies, or remedy closure. In addition, a recent National Research Council study examined groundwater remediation at complex contaminated sites and concluded that it may be beneficial to evaluate remedy performance and the potential need for transition to alternative approaches at these sites. The intent of this document is to provide a structured approach for assessing P&T performance to support a decision to optimize, transition, or close a P&T remedy. The process presented in this document for gathering information and performing evaluations to support P&T remedy decisions includes use of decision elements to distinguish between potential outcomes of a remedy decision. Case studies are used to augment descriptions of decision elements and to illustrate each type of outcome identified in the performance assessment approach. The document provides references to resources for tools and other guidance relevant to conducting the P&T assessment.

  6. Electronic Transitions of Ruthenium Monoxide

    NASA Astrophysics Data System (ADS)

    Wang, Na; Ng, Y. W.; Cheung, A. S.-C.

    2013-06-01

    The electronic transition spectrum of ruthenium monoxide (RuO) molecule in the spectral region between 545nm to 640nm has been recorded and analyzed using laser ablation/reaction free-jet expansion and laser induced fluorescence spectroscopy. The RuO molecule was produced by reacting laser- ablated ruthenium atoms with N_{2}O seeded in argon. Nine vibrational bands were recorded and they are identified to be belonging to four electronic transition systems, namely the [18.1]Ω = 4 - X^{5} Δ_4 transition, [16.0]^{5} Φ_5 - X^{5} Δ_4 transition, [18.1]Ω = 3 - X^{5} Δ_3, and [15.8] ^{5} Φ_4 - X^{5} Δ_3 transition. RuO has been determined to have a X^{5} Δ_4 ground state. A least squares fit of the measured rotational lines yielded molecular constants for the ground and the low-lying electronic states. A molecular orbital energy level diagram has been used to help with the assignment of the observed electronic states.

  7. Observation of optomechanical buckling transitions

    PubMed Central

    Xu, H.; Kemiktarak, U.; Fan, J.; Ragole, S.; Lawall, J.; Taylor, J. M.

    2017-01-01

    Correlated phases of matter provide long-term stability for systems as diverse as solids, magnets and potential exotic quantum materials. Mechanical systems, such as buckling transition spring switches, can have engineered, stable configurations whose dependence on a control variable is reminiscent of non-equilibrium phase transitions. In hybrid optomechanical systems, light and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, storing and processing information, and ultimately probing and controlling behaviour at the quantum level. Here we report the observation of first- and second-order buckling transitions between stable mechanical states in an optomechanical system, in which full control of the nature of the transition is obtained by means of the laser power and detuning. The underlying multiwell confining potential we create is highly tunable, with a sub-nanometre distance between potential wells. Our results enable new applications in photonics and information technology, and may enable explorations of quantum phase transitions and macroscopic quantum tunnelling in mechanical systems. PMID:28248293

  8. Electromechanical transition in quantum dots

    NASA Astrophysics Data System (ADS)

    Micchi, G.; Avriller, R.; Pistolesi, F.

    2016-09-01

    The strong coupling between electronic transport in a single-level quantum dot and a capacitively coupled nanomechanical oscillator may lead to a transition towards a mechanically bistable and blocked-current state. Its observation is at reach in carbon-nanotube state-of-art experiments. In a recent publication [Phys. Rev. Lett. 115, 206802 (2015), 10.1103/PhysRevLett.115.206802] we have shown that this transition is characterized by pronounced signatures on the oscillator mechanical properties: the susceptibility, the displacement fluctuation spectrum, and the ring-down time. These properties are extracted from transport measurements, however the relation between the mechanical quantities and the electronic signal is not always straightforward. Moreover the dependence of the same quantities on temperature, bias or gate voltage, and external dissipation has not been studied. The purpose of this paper is to fill this gap and provide a detailed description of the transition. Specifically we find (i) the relation between the current-noise and the displacement spectrum; (ii) the peculiar behavior of the gate-voltage dependence of these spectra at the transition; (iii) the robustness of the transition towards the effect of external fluctuations and dissipation.

  9. Observation of optomechanical buckling transitions

    NASA Astrophysics Data System (ADS)

    Xu, H.; Kemiktarak, U.; Fan, J.; Ragole, S.; Lawall, J.; Taylor, J. M.

    2017-03-01

    Correlated phases of matter provide long-term stability for systems as diverse as solids, magnets and potential exotic quantum materials. Mechanical systems, such as buckling transition spring switches, can have engineered, stable configurations whose dependence on a control variable is reminiscent of non-equilibrium phase transitions. In hybrid optomechanical systems, light and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, storing and processing information, and ultimately probing and controlling behaviour at the quantum level. Here we report the observation of first- and second-order buckling transitions between stable mechanical states in an optomechanical system, in which full control of the nature of the transition is obtained by means of the laser power and detuning. The underlying multiwell confining potential we create is highly tunable, with a sub-nanometre distance between potential wells. Our results enable new applications in photonics and information technology, and may enable explorations of quantum phase transitions and macroscopic quantum tunnelling in mechanical systems.

  10. Simulation methods for looping transitions.

    PubMed

    Gaffney, B J; Silverstone, H J

    1998-09-01

    Looping transitions occur in field-swept electron magnetic resonance spectra near avoided crossings and involve a single pair of energy levels that are in resonance at two magnetic field strengths, before and after the avoided crossing. When the distance between the two resonances approaches a linewidth, the usual simulation of the spectra, which results from a linear approximation of the dependence of the transition frequency on magnetic field, breaks down. A cubic approximation to the transition frequency, which can be obtained from the two resonance fields and the field-derivatives of the transition frequencies, along with linear (or better) interpolation of the transition-probability factor, restores accurate simulation. The difference is crucial for accurate line shapes at fixed angles, as in an oriented single crystal, but the difference turns out to be a smaller change in relative intensity for a powder spectrum. Spin-3/2 Cr3+ in ruby and spin-5/2 Fe3+ in transferrin oxalate are treated as examples.

  11. Major transitions in human evolution

    PubMed Central

    Foley, Robert A.; Martin, Lawrence; Mirazón Lahr, Marta; Stringer, Chris

    2016-01-01

    Evolutionary problems are often considered in terms of ‘origins', and research in human evolution seen as a search for human origins. However, evolution, including human evolution, is a process of transitions from one state to another, and so questions are best put in terms of understanding the nature of those transitions. This paper discusses how the contributions to the themed issue ‘Major transitions in human evolution’ throw light on the pattern of change in hominin evolution. Four questions are addressed: (1) Is there a major divide between early (australopithecine) and later (Homo) evolution? (2) Does the pattern of change fit a model of short transformations, or gradual evolution? (3) Why is the role of Africa so prominent? (4) How are different aspects of adaptation—genes, phenotypes and behaviour—integrated across the transitions? The importance of developing technologies and approaches and the enduring role of fieldwork are emphasized. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298461

  12. Observation of optomechanical buckling transitions.

    PubMed

    Xu, H; Kemiktarak, U; Fan, J; Ragole, S; Lawall, J; Taylor, J M

    2017-03-01

    Correlated phases of matter provide long-term stability for systems as diverse as solids, magnets and potential exotic quantum materials. Mechanical systems, such as buckling transition spring switches, can have engineered, stable configurations whose dependence on a control variable is reminiscent of non-equilibrium phase transitions. In hybrid optomechanical systems, light and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, storing and processing information, and ultimately probing and controlling behaviour at the quantum level. Here we report the observation of first- and second-order buckling transitions between stable mechanical states in an optomechanical system, in which full control of the nature of the transition is obtained by means of the laser power and detuning. The underlying multiwell confining potential we create is highly tunable, with a sub-nanometre distance between potential wells. Our results enable new applications in photonics and information technology, and may enable explorations of quantum phase transitions and macroscopic quantum tunnelling in mechanical systems.

  13. Phonon Analysis in Multiphonon Transitions

    NASA Astrophysics Data System (ADS)

    Huang, Kun; Gu, Zongquan

    In the investigation of multiphonon transitions, single-mode or single-frequency models are widely used. In view of the fact that such oversimplified models can be seriously inadequate, the present work bridges the gap between the complexity of the general formal theory and the simplicity required for concrete applications by introducing the concept of multi-frequency models. That is, the theory is so formulated that a general system can be approximated by multi-frequency models of any degree of elaboration. A statistical thermodynamic formalism is developed for treating such multi-frequency models, which, on the one hand, greatly reduces the labour of calculation with such models and, on the other hand, leads directly to a simple statistical distribution law for numbers of phonons of each frequency participating in a multiphonon transition. Applications of the theory to concrete models lead to certain general conclusions on frequency dispersion effects in multiphonon transitions. The use of the theory is further demonstrated by fully accounting for the paradoxical experimental results reported by Jia and Yen that the isotopic substitution of H by D in CsMn Cl3· 2H2O reduces the multiphonon nonradiative transition probability of excited Mn2+ ion by more than ten-fold, and yet leaves the corresponding luminescence phonon sideband little changed. In the last section of the paper, the relation between the statistical thermodynamic formalism and existing multiphonon transition theory is elucidated, thereby the theoretical basis of the statistical formalism becomes clearly defined.

  14. The major synthetic evolutionary transitions

    PubMed Central

    Solé, Ricard

    2016-01-01

    Evolution is marked by well-defined events involving profound innovations that are known as ‘major evolutionary transitions'. They involve the integration of autonomous elements into a new, higher-level organization whereby the former isolated units interact in novel ways, losing their original autonomy. All major transitions, which include the origin of life, cells, multicellular systems, societies or language (among other examples), took place millions of years ago. Are these transitions unique, rare events? Have they instead universal traits that make them almost inevitable when the right pieces are in place? Are there general laws of evolutionary innovation? In order to approach this problem under a novel perspective, we argue that a parallel class of evolutionary transitions can be explored involving the use of artificial evolutionary experiments where alternative paths to innovation can be explored. These ‘synthetic’ transitions include, for example, the artificial evolution of multicellular systems or the emergence of language in evolved communicating robots. These alternative scenarios could help us to understand the underlying laws that predate the rise of major innovations and the possibility for general laws of evolved complexity. Several key examples and theoretical approaches are summarized and future challenges are outlined. This article is part of the themed issue ‘The major synthetic evolutionary transitions’. PMID:27431528

  15. 33 CFR 401.74 - Transit declaration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Transit declaration. 401.74... Transit declaration. (a) Seaway Transit Declaration Form (Cargo and Passenger) shall be forwarded to the... ships, within fourteen days after the vessel enters the Seaway on any upbound or downbound transit....

  16. 33 CFR 401.74 - Transit declaration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Transit declaration. 401.74... Transit declaration. (a) A Seaway Transit Declaration Form (Cargo and Passenger) shall be forwarded to the... bound transit. The form may be obtained from the St. Lawrence Management Corporation, 151 Ecluse...

  17. 33 CFR 401.74 - Transit declaration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Transit declaration. 401.74... Transit declaration. (a) Seaway Transit Declaration Form (Cargo and Passenger) shall be forwarded to the... ships, within fourteen days after the vessel enters the Seaway on any upbound or downbound transit....

  18. 33 CFR 401.74 - Transit declaration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Transit declaration. 401.74... Transit declaration. (a) Seaway Transit Declaration Form (Cargo and Passenger) shall be forwarded to the... ships, within fourteen days after the vessel enters the Seaway on any upbound or downbound transit....

  19. 33 CFR 401.74 - Transit declaration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Transit declaration. 401.74... Transit declaration. (a) Seaway Transit Declaration Form (Cargo and Passenger) shall be forwarded to the... ships, within fourteen days after the vessel enters the Seaway on any upbound or downbound transit....

  20. Individualized Transition Plans (ITP): A National Perspective.

    ERIC Educational Resources Information Center

    Repetto, Jeanne B.; And Others

    1990-01-01

    Information concerning implementation of Individualized Transition Plans (ITP) was collected from 46 states and analyzed to determine documentation used in transition planning, relationship between the ITP and Individualized Education Programs, age for beginning transition planning, individuals involved in transition planning, and issues addressed…

  1. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  2. 29 CFR 36.230 - Transition plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Transition plans. 36.230 Section 36.230 Labor Office of the... FEDERAL FINANCIAL ASSISTANCE Coverage § 36.230 Transition plans. (a) Submission of plans. An institution... submit either a single transition plan applicable to all such units, or a separate transition...

  3. 18 CFR 1317.230 - Transition plans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Transition plans. 1317... Coverage § 1317.230 Transition plans. (a) Submission of plans. An institution to which § 1317.225 applies... transition plan applicable to all such units, or a separate transition plan applicable to each such unit....

  4. 7 CFR 15a.18 - Transition plans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Transition plans. 15a.18 Section 15a.18 Agriculture... FEDERAL FINANCIAL ASSISTANCE Coverage § 15a.18 Transition plans. (a) Submission of plans. An institution... submit either a single transition plan applicable to all such units, or a separate transition...

  5. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  6. 36 CFR 1211.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Transition plans. 1211.230... FINANCIAL ASSISTANCE Coverage § 1211.230 Transition plans. (a) Submission of plans. An institution to which... a single transition plan applicable to all such units, or a separate transition plan applicable...

  7. 7 CFR 15a.18 - Transition plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Transition plans. 15a.18 Section 15a.18 Agriculture... FEDERAL FINANCIAL ASSISTANCE Coverage § 15a.18 Transition plans. (a) Submission of plans. An institution... submit either a single transition plan applicable to all such units, or a separate transition...

  8. 44 CFR 19.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Transition plans. 19.230... RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 19.230 Transition plans. (a) Submission of plans. An... submit either a single transition plan applicable to all such units, or a separate transition...

  9. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  10. 45 CFR 2555.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Transition plans. 2555.230 Section 2555.230 Public... Coverage § 2555.230 Transition plans. (a) Submission of plans. An institution to which § 2555.225 applies... transition plan applicable to all such units, or a separate transition plan applicable to each such unit....

  11. 29 CFR 36.230 - Transition plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Transition plans. 36.230 Section 36.230 Labor Office of the... FEDERAL FINANCIAL ASSISTANCE Coverage § 36.230 Transition plans. (a) Submission of plans. An institution... submit either a single transition plan applicable to all such units, or a separate transition...

  12. 7 CFR 15a.18 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Transition plans. 15a.18 Section 15a.18 Agriculture... FEDERAL FINANCIAL ASSISTANCE Coverage § 15a.18 Transition plans. (a) Submission of plans. An institution... submit either a single transition plan applicable to all such units, or a separate transition...

  13. 32 CFR 196.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Transition plans. 196.230 Section 196.230... FINANCIAL ASSISTANCE Coverage § 196.230 Transition plans. (a) Submission of plans. An institution to which... a single transition plan applicable to all such units, or a separate transition plan applicable...

  14. 32 CFR 196.230 - Transition plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Transition plans. 196.230 Section 196.230... FINANCIAL ASSISTANCE Coverage § 196.230 Transition plans. (a) Submission of plans. An institution to which... a single transition plan applicable to all such units, or a separate transition plan applicable...

  15. 36 CFR 1211.230 - Transition plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Transition plans. 1211.230... FINANCIAL ASSISTANCE Coverage § 1211.230 Transition plans. (a) Submission of plans. An institution to which... a single transition plan applicable to all such units, or a separate transition plan applicable...

  16. 32 CFR 196.230 - Transition plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Transition plans. 196.230 Section 196.230... FINANCIAL ASSISTANCE Coverage § 196.230 Transition plans. (a) Submission of plans. An institution to which... a single transition plan applicable to all such units, or a separate transition plan applicable...

  17. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  18. 7 CFR 15a.18 - Transition plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Transition plans. 15a.18 Section 15a.18 Agriculture... FEDERAL FINANCIAL ASSISTANCE Coverage § 15a.18 Transition plans. (a) Submission of plans. An institution... submit either a single transition plan applicable to all such units, or a separate transition...

  19. Rapid near-optimal aerospace plane trajectory generation and guidance

    NASA Technical Reports Server (NTRS)

    Corban, J. E.; Calise, A. J.; Flandro, G. A.

    1991-01-01

    Problems associated with onboard trajectory optimization, propulsion system cycle selection, and the synthesis of guidance laws are addressed for ascent to low earth orbit of an airbreathing, single-stage-to-orbit vehicle. A multicycle propulsion system is assumed that incorporates turbojet, ramjet, scramjet, and rocket engines. An energy state approximation is applied to a singularly perturbed, four-state dynamic model for flight of a point mass over a spherical nonrotating earth. An algorithm is then derived for generating both the fuel-optimal climb profile and the guidance commands required to follow that profile. In particular, analytic switching conditions are derived that, under appropriate assumptions, efficiently govern optimal transition from one propulsion cycle to another. The algorithm proves to be computationally efficient and suitable for real-time implementation. The paper concludes with the presentation of representative numerical results that illustrate the nature of the fuel-optimal climb paths and the tracking performance of the guidance algorithm.

  20. Structure of the optimal path to a fluctuation

    NASA Astrophysics Data System (ADS)

    Tizón-Escamilla, N.; Hurtado, P. I.; Garrido, P. L.

    2017-03-01

    Macroscopic fluctuations have become an essential tool to understand physics far from equilibrium due to the link between their statistics and nonequilibrium ensembles. The optimal path leading to a fluctuation encodes key information on this problem, shedding light on, e.g., the physics behind the enhanced probability of rare events out of equilibrium, the possibility of dynamic phase transitions, and new symmetries. This makes the understanding of the properties of these optimal paths a central issue. Here we derive a fundamental relation which strongly constrains the architecture of these optimal paths for general d -dimensional nonequilibrium diffusive systems, and implies a nontrivial structure for the dominant current vector fields. Interestingly, this general relation (which encompasses and explains previous results) makes manifest the spatiotemporal nonlocality of the current statistics and the associated optimal trajectories.

  1. Do Transitive Preferences Always Result in Indifferent Divisions?

    NASA Astrophysics Data System (ADS)

    Makowski, Marcin; Piotrowski, Edward; Sładkowski, Jan

    2015-03-01

    The transitivity of preferences is one of the basic assumptions used in the theory of games and decisions. It is often equated with rationality of choice and is considered useful in building rankings. Intransitive preferences are considered paradoxical and undesirable. This problem is discussed by many social and natural sciences. The paper discusses a simple model of sequential game in which two players in each iteration of the game choose one of the two elements. They make their decisions in different contexts defined by the rules of the game. It appears that the optimal strategy of one of the players can only be intransitive! (the so-called \\textsl{relevant intransitive strategies}.) On the other hand, the optimal strategy for the second player can be either transitive or intransitive. A quantum model of the game using pure one-qubit strategies is considered. In this model, an increase in importance of intransitive strategies is observed -- there is a certain course of the game where intransitive strategies are the only optimal strategies for both players. The study of decision-making models using quantum information theory tools may shed some new light on the understanding of mechanisms that drive the formation of types of preferences.

  2. Sliding Over a Phase Transition

    NASA Astrophysics Data System (ADS)

    Tosatti, Erio; Benassi, Andrea; Vanossi, Andrea; Santoro, Giuseppe E.

    2011-03-01

    The frictional response experienced by a stick-slip slider when a phase transition occurs in the underlying solid substrate is a potentially exciting, poorly explored problem. We show, based on 2-dimensional simulations modeling the sliding of a nanotip, that indeed friction may be heavily affected by a continuous structural transition. First, friction turns nonmonotonic as temperature crosses the transition, peaking at the critical temperature Tc where fluctuations are strongest. Second, below Tc friction depends upon order parameter directions, and is much larger for those where the frictional slip can cause a local flip. This may open a route towards control of atomic scale friction by switching the order parameter direction by an external field or strain, with possible application to e.g., displacive ferroelectrics such as BaTi O3 , as well as ferro- and antiferro-distortive materials. Supported by project ESF FANAS/AFRI sponsored by the Italian Research Council (CNR).

  3. Electronic transitions of iridium monophosphide

    NASA Astrophysics Data System (ADS)

    Yang, M.; Chan, Man-Chor; Cheung, A. S.-C.

    2016-05-01

    Laser induced fluorescence spectrum of IrP in the near infrared spectral region between 720 and 820 nm has been recorded and analyzed. Six vibrational bands with resolved rotational structure for both 191IrP and 193IrP were analyzed, they have been grouped into three new electronic transitions: the [13.6] Ω = 2 - a3Π2, the [12.3]1Π1-X1Σ+, and the [12.7]1Π1-X1Σ+ transitions. Ab initio calculation results were used to aid the assignment of the observed transitions. A new triplet state has been observed for the first time. The observed electronic states of IrP are compared with those of the isovalent IrN molecule.

  4. Alternative approaches to fertility transition.

    PubMed

    Micheli, G A

    1995-01-01

    "Using anomalies of the Italian case as the basis, the aim of this article is to verify how the theoretical framework [of demographic transition] put forward by Lesthaeghe can be interpreted.... While the changes in mores in the Italy of the economic boom were a component of the large-scale processes of secularization, rationalization and modernization specific to the [first demographic transition], the practices, values and models of the collective imagination characterizing the second phase of Lesthaeghe's [second demographic transition] are marked by a state of mind that cannot be put down to the 'spirit of the age' during the years of large-scale modernization, but to the emancipatory and 'rational' falling away of many of the barriers to the unfolding of individual life destiny over and above that based on class, gender and age."

  5. Transition metals in superheat melts

    NASA Technical Reports Server (NTRS)

    Jakes, Petr; Wolfbauer, Michael-Patrick

    1993-01-01

    A series of experiments with silicate melts doped with transition element oxides was carried out at atmospheric pressures of inert gas at temperatures exceeding liquidus. As predicted from the shape of fO2 buffer curves in T-fO2 diagrams the reducing conditions for a particular oxide-metal pair can be achieved through the T increase if the released oxygen is continuously removed. Experimental studies suggest that transition metals such as Cr or V behave as siderophile elements at temperatures exceeding liquidus temperatures if the system is not buffered by the presence of other oxide of more siderophile element. For example the presence of FeO prevents the reduction of Cr2O3. The sequence of decreasing siderophility of transition elements at superheat conditions (Mo, Ni, Fe, Cr) matches the decreasing degree of depletion of siderophile elements in mantle rocks as compared to chondrites.

  6. Reactivity of transition metal solvates

    NASA Astrophysics Data System (ADS)

    Berezin, Boris D.

    1991-09-01

    Reactivity data are generalised for one of the most important classes of complexes, solvates, which are quantitatively nearly unstudied. Various approaches to studying and describing the reactivity are compared with respect to solvation of the reagents and the transition state. The specifics and mechanism of ligand substitution in pure and mixed organic solvents are found. The reactivity of simple (homoleptic) and mixed solvates toward macrocycles is examined in detail using porphyrins as an example. The kinetic method of indicator reactions is applied to porphyrins in order to study the state of transition metal salts in organic solvents and the stability of the coordination spheres of acidosalts (MXnn-2), acidosolvates (MX2Sn-2) and their transition states. The concentration dependence of the rate constant of an indicator reaction is demonstrated to be due to a change in the inner coordination sphere and a shift of equilibria between the various coordination complexes. The bibliography includes 38 references.

  7. Shape optimization and CAD

    NASA Technical Reports Server (NTRS)

    Rasmussen, John

    1990-01-01

    Structural optimization has attracted the attention since the days of Galileo. Olhoff and Taylor have produced an excellent overview of the classical research within this field. However, the interest in structural optimization has increased greatly during the last decade due to the advent of reliable general numerical analysis methods and the computer power necessary to use them efficiently. This has created the possibility of developing general numerical systems for shape optimization. Several authors, eg., Esping; Braibant & Fleury; Bennet & Botkin; Botkin, Yang, and Bennet; and Stanton have published practical and successful applications of general optimization systems. Ding and Homlein have produced extensive overviews of available systems. Furthermore, a number of commercial optimization systems based on well-established finite element codes have been introduced. Systems like ANSYS, IDEAS, OASIS, and NISAOPT are widely known examples. In parallel to this development, the technology of computer aided design (CAD) has gained a large influence on the design process of mechanical engineering. The CAD technology has already lived through a rapid development driven by the drastically growing capabilities of digital computers. However, the systems of today are still considered as being only the first generation of a long row of computer integrated manufacturing (CIM) systems. These systems to come will offer an integrated environment for design, analysis, and fabrication of products of almost any character. Thus, the CAD system could be regarded as simply a database for geometrical information equipped with a number of tools with the purpose of helping the user in the design process. Among these tools are facilities for structural analysis and optimization as well as present standard CAD features like drawing, modeling, and visualization tools. The state of the art of structural optimization is that a large amount of mathematical and mechanical techniques are

  8. Target of Opportunity: New Transiting Exoplanets

    NASA Astrophysics Data System (ADS)

    Harrington, Joseph; Bakos, Gaspar; Deming, Drake; Fischer, Debra; Seager, Sara; Wheatley, Peter

    2007-05-01

    We propose a Target of Opportunity (ToO) program to observe eclipses of new extrasolar planets. The measured band fluxes constrain models of composition, chemistry, and atmospheric dynamics. They also provide the basic information needed for follow-on work. Since the spacecraft is nearing the end of its limited lifetime, rapid characterization is crucial. Well below Spitzer's nominal sensitivity, these measurements are challenging, and optimized observing and analysis techniques that are not obvious are required to bring in the best signal. Many Discretionary Time proposals have been approved on this topic. Our goals, achieved with our Cycle-3 ToO program and continued here, are to ensure that each bandpass is observed for every planet with good predicted S/N, to obtain the best possible observations, to make these high-impact data public for everyone to use in planning followups, and to make the process of observing exoplanets smooth for observers and Spitzer by allocating a predictable number of events for the community through the TAC process. Based on actual discovery statistics and the known quantities of survey data in hand, we confidently predict about 22 new transiting-planet announcements in the coming year. Of these, one may be bright enough to measure in six bandpasses, and several may be marginal for Spitzer. We thus request 120 hours to cover about 18 6:40-hour eclipse events in low-impact ToOs. We provide quantitative criteria for activating ToOs. Our archival product will be calibrated lightcurves, to be submitted as electronic attachments with journal articles. Transiting extrasolar planets are among the least anticipated and most productive targets for Spitzer. They are also among the most publicly stimulating. These direct measurements provide the only emission fluxes possible with current telescopes for extrasolar planets, and stand as a Spitzer legacy for posterity. The next opportunity to observe them is with JWST.

  9. Optimized Kernel Entropy Components.

    PubMed

    Izquierdo-Verdiguier, Emma; Laparra, Valero; Jenssen, Robert; Gomez-Chova, Luis; Camps-Valls, Gustau

    2016-02-25

    This brief addresses two main issues of the standard kernel entropy component analysis (KECA) algorithm: the optimization of the kernel decomposition and the optimization of the Gaussian kernel parameter. KECA roughly reduces to a sorting of the importance of kernel eigenvectors by entropy instead of variance, as in the kernel principal components analysis. In this brief, we propose an extension of the KECA method, named optimized KECA (OKECA), that directly extracts the optimal features retaining most of the data entropy by means of compacting the information in very few features (often in just one or two). The proposed method produces features which have higher expressive power. In particular, it is based on the independent component analysis framework, and introduces an extra rotation to the eigen decomposition, which is optimized via gradient-ascent search. This maximum entropy preservation suggests that OKECA features are more efficient than KECA features for density estimation. In addition, a critical issue in both the methods is the selection of the kernel parameter, since it critically affects the resulting performance. Here, we analyze the most common kernel length-scale selection criteria. The results of both the methods are illustrated in different synthetic and real problems. Results show that OKECA returns projections with more expressive power than KECA, the most successful rule for estimating the kernel parameter is based on maximum likelihood, and OKECA is more robust to the selection of the length-scale parameter in kernel density estimation.

  10. Optimization of Heat Exchangers

    SciTech Connect

    Ivan Catton

    2010-10-01

    The objective of this research is to develop tools to design and optimize heat exchangers (HE) and compact heat exchangers (CHE) for intermediate loop heat transport systems found in the very high temperature reator (VHTR) and other Generation IV designs by addressing heat transfer surface augmentation and conjugate modeling. To optimize heat exchanger, a fast running model must be created that will allow for multiple designs to be compared quickly. To model a heat exchanger, volume averaging theory, VAT, is used. VAT allows for the conservation of mass, momentum and energy to be solved for point by point in a 3 dimensional computer model of a heat exchanger. The end product of this project is a computer code that can predict an optimal configuration for a heat exchanger given only a few constraints (input fluids, size, cost, etc.). As VAT computer code can be used to model characteristics )pumping power, temperatures, and cost) of heat exchangers more quickly than traditional CFD or experiment, optimization of every geometric parameter simultaneously can be made. Using design of experiment, DOE and genetric algorithms, GE, to optimize the results of the computer code will improve heat exchanger disign.

  11. On optimal Bayes detection

    SciTech Connect

    Nielsen, P. |

    1991-08-12

    The following is intended to be a short introduction to the design and analysis of a Bayes-optimal detector, and Middleton`s Locally Optimum Bayes Detector (LOBD). The relationship between these two detectors is clarified. There are three examples of varying complexity included to illustrate the design of these detectors. The final example illustrates the difficulty involved in choosing the bias function for the LOBD. For the examples, the corrupting noise is Gaussian. This allows for a relatively easy solution to the optimal and the LOBD structures. As will be shown, for Bayes detection, the threshold is determined by the costs associated with making a decision and the a priori probabilities of each hypothesis. The threshold of the test cannot be set by simulation. One will notice that the optimal Bayes detector and the LOBD look very much like the Neyman-Pearson optimal and locally optimal detectors respectively. In the latter cases though, the threshold is set by a constraint on the false alarm probability. Note that this allows the threshold to be set by simulation.

  12. On optimal Bayes detection

    SciTech Connect

    Nielsen, P. Arizona Univ., Tucson, AZ . Dept. of Electrical and Computer Engineering)

    1991-08-12

    The following is intended to be a short introduction to the design and analysis of a Bayes-optimal detector, and Middleton's Locally Optimum Bayes Detector (LOBD). The relationship between these two detectors is clarified. There are three examples of varying complexity included to illustrate the design of these detectors. The final example illustrates the difficulty involved in choosing the bias function for the LOBD. For the examples, the corrupting noise is Gaussian. This allows for a relatively easy solution to the optimal and the LOBD structures. As will be shown, for Bayes detection, the threshold is determined by the costs associated with making a decision and the a priori probabilities of each hypothesis. The threshold of the test cannot be set by simulation. One will notice that the optimal Bayes detector and the LOBD look very much like the Neyman-Pearson optimal and locally optimal detectors respectively. In the latter cases though, the threshold is set by a constraint on the false alarm probability. Note that this allows the threshold to be set by simulation.

  13. Presidential Transition Teams: Fostering a Collaborative Transition Process

    ERIC Educational Resources Information Center

    Artman, Richard B.; Franz, Mark

    2009-01-01

    Whether hiring a sitting president or one beginning a first presidency, the board of trustees should be keenly interested in ensuring that the new president's first months in office flow as smoothly as possible. Increasing attention has been paid in recent years to the idea of using a transition team to assist the new president. Using a transition…

  14. Wetting transition on patterned surfaces: transition states and energy barriers.

    PubMed

    Ren, Weiqing

    2014-03-18

    We study the wetting transition on microstructured hydrophobic surfaces. We use the string method [J. Chem. Phys. 2007, 126, 164103; J. Chem. Phys. 2013, 138, 134105] to accurately compute the transition states, the energy barriers, and the minimum energy paths for the wetting transition from the Cassie-Baxter state to the Wenzel state. Numerical results are obtained for the wetting of a hydrophobic surface textured with a square lattice of pillars. It is found that the wetting of the solid substrate occurs via infiltration of the liquid in a single groove, followed by lateral propagation of the liquid front. The propagation of the liquid front proceeds in a stepwise manner, and a zipping mechanism is observed during the infiltration of each layer. The minimum energy path for the wetting transition goes through a sequence of intermediate metastable states, whose wetted areas reflect the microstructure of the patterned surface. We also study the dependence of the energy barrier on the drop size and the gap between the pillars.

  15. Theoretical Studies of Atomic Transitions

    SciTech Connect

    Charlotte Froese Fischer

    2005-07-08

    Atomic structure calculations were performed for properties such as energy levels, binding energies, transition probabilities, lifetimes, hyperfine structure, and isotope shifts. Accurate computational procedures were devised so that properties could be predicted even when they could not be obtained from experiment, and to assist in the identification of observed data. The method used was the multiconfiguration Hartree-Fock (MCHF) method, optionally corrected for relativistic effects in the Breit-Pauli approximation. Fully relativistic Dirac-Fock calculations also were performed using the GRASP code A database of energy levels, lifetimes, and transition probabilities was designed and implemented and, at present, includes many results for Be-like to Ar-like.

  16. Thailand's Work and Health Transition.

    PubMed

    Kelly, Matthew; Strazdins, Lyndall; Dellora, Tarie; Khamman, Suwanee; Seubsman, Sam-Ang; Sleigh, Adrian C

    2010-09-01

    Thailand has experienced a rapid economic transition from agriculture to industry and services, and from informal to formal employment. It has much less state regulation and worker representation relative to developed nations, who underwent these transitions more slowly and sequentially, decades earlier. We examine the strengthening of Thai government policy and legislation affecting worker's health, responding to international norms, a new democratic constitution, fear of foreign importer embargos and several fatal workplace disasters. We identify key challenges remaining for Thai policy makers, including legislation enforcement and the measurement of impacts on worker's mental and physical health.

  17. William Crabtree's Venus transit observation

    NASA Astrophysics Data System (ADS)

    Kollerstrom, Nicholas

    2005-04-01

    The close collaboration between the two North-country astronomers Jeremiah Horrocks and William Crabtree gave them special insight into the new astronomy published by the recently-deceased Kepler, whereby Horrocks became the only person to apprehend that the Rudolphine tables were in fact predicting a Venus transit in 1639. This paper focuses especially upon William Crabtree's role and contribution. A comparison is made with an earlier, unsuccessful endeavour by these two concerning a possible transit of Mercury. Much of the record of their work was lost during the civil war. Finally, thanks to Christiaan Huygens, Horrock's manuscript was published by Johannes Hevelius in Danzig, in 1662.

  18. Mode Transition of Trichel pulses

    NASA Astrophysics Data System (ADS)

    Kexin, Zhang; Yongjun, Piao; Miao, Tang; Jingfeng, Tang; Liqiu, Wei; Chaohai, Zhang

    2015-11-01

    The trichel pulse is a typical kind of negative corona current observed in electronegative gases. In this work, stochastic behavior of the trichel pulse has been investigated. The experiment is performed in a negative corona reactor consisting of a stainless steel pin and a stainless steel powered by a dc high voltage source. The characteristic parameters distributions of corona current pulses, including the amplitude, rise time, half-wave time, and repetition frequency, are analyzed statistically. The results show there is a mode transition during the period of voltage increasing. This transition process happens in a certain voltage region, and change of pulse amplitude is the main difference between the two modes.

  19. Probabilities of transversions and transitions.

    PubMed

    Vol'kenshtein, M V

    1976-01-01

    The values of the mean relative probabilities of transversions and transitions have been refined on the basis of the data collected by Jukes and found to be equal to 0.34 and 0.66, respectively. Evolutionary factors increase the probability of transversions to 0.44. The relative probabilities of individual substitutions have been determined, and a detailed classification of the nonsense mutations has been given. Such mutations are especially probable in the UGG (Trp) codon. The highest probability of AG, GA transitions correlates with the lowest mean change in the hydrophobic nature of the amino acids coded.

  20. Epigenetic switches and network transitions

    NASA Astrophysics Data System (ADS)

    Sasai, Masaki

    2012-02-01

    We investigate dynamics of gene networks which are regulated by both the fast binding/unbinding of transcription factors to/from DNA and the slow processes of chromatin structural change or histone modification. This heterogeneous dynamics consisting of different time scales is analyzed by the mean-field approximation and the stochastic simulation to show that the network exhibits multiple metastable states and is characterized by transitions among them. We discuss distribution and fluctuation of states of the core gene network of embryonic stem cells as an example of such heterogeneous dynamics and the simulated transitions are compared with the experimental data on the distribution of stem cell states.