Science.gov

Sample records for indirect approach focusing

  1. Science Focus: The Salters' Approach.

    ERIC Educational Resources Information Center

    Berg, Kevin de

    1995-01-01

    Outlines the Salter's approach to teaching and learning science at the Junior Secondary level by showing how the phenomenon of fire is treated in curriculum materials. Discusses contents of the teachers' guide, student texts, and assessment pack. Gives an evaluation of the usefulness of the approach in the Australian context. (Author/MKR)

  2. Organisational Change: A Solution-Focused Approach

    ERIC Educational Resources Information Center

    Morgan, Gavin

    2016-01-01

    This study investigates the effectiveness of a solution-focused approach to organisational change. Planning Alternative Tomorrows with Hope (PATH) is an intervention more commonly applied to individuals. In this study the intervention is used with groups of people working in educational organisations to help manage the change process. The approach…

  3. Reading Comprehension of Informative Texts in Secondary School: A Focus on Direct and Indirect Effects of Reader's Prior Knowledge

    ERIC Educational Resources Information Center

    Tarchi, Christian

    2010-01-01

    Text comprehension plays a fundamental role in the processes of acquisition, sharing, and construction of knowledge. Most definitions share the focus on the interaction between text and reader's prior knowledge. In this paper both direct and indirect effects of prior knowledge on reading comprehension have been analyzed, along with other…

  4. Direct and Indirect Approaches to Increasing Conceptual Survey Gains

    NASA Astrophysics Data System (ADS)

    Kohl, Patrick B.; Pearl, Charles; Kuo, H. Vincent

    2010-10-01

    Conceptual surveys like the FCI and CSEM are common, and course reforms often have the goal of improving student gains on these surveys. There exist various approaches to improving said gains, and there is occasionally concern that such methods "teach to the test" excessively. To our knowledge, however, there has been little direct experimentation on whether teaching to the test, even intentionally, has the expected result. In this paper, we report on a simple two-semester experiment involving ˜900 students where we tried two different approaches to improving CSEM gains in an introductory E&M class. In the first trial, we gave students many of the questions from the CSEM as Peer Instruction-style clicker questions in lecture. In the second, we redeveloped parts of our Studio physics curriculum to target CSEM concepts without replicating CSEM questions. Comparing the CSEM gains in the experimental sections to the previous year's sections, we find that the first trial resulted in significant (˜0.20) shifts in normalized gains on the relevant questions, while the second trial resulted in minimal or no shifts.

  5. The Surrogate Method - An Indirect Approach to Compound-Nucleus Reactions

    SciTech Connect

    Escher, J; Ahle, L; Bernstein, L; Burke, J; Church, J A; Dietrich, F; Forssen, C; Hoffman, R; Gueorguiev, V

    2005-04-06

    An indirect method for determining cross sections for reactions proceeding through a compound nucleus is presented. Exploring indirect approaches for obtaining reaction cross sections is important since a large number of reactions relevant to astrophysics cannot be measured with currently available techniques. Of particular importance are reactions involving unstable nuclei. Some applications of the Surrogate nuclear reactions method are considered and challenges that need to be addressed are outlined.

  6. A New Approach to Calculate Indirect GWPs using the UIUC 2-D CRT and RTM Model

    NASA Astrophysics Data System (ADS)

    Li, Y.; Youn, D.; Patten, K.; Wuebbles, D.

    2006-12-01

    Global warming potentials (GWPs) are defined to be the total impact over time of adding a unit mass of a greenhouse gas to the atmosphere. Indirect GWPs are due to ozone depletion effects in the stratosphere for a certain compound and therefore stand for the long-term global cooling effects. Previously, indirect GWPs were calculated using a box model, which was not able to consider the complex processes in the atmosphere. As a step towards obtaining indirect GWPs through a more robust approach, the UIUC 2-D CRT model was used as the computational tool to derive ozone changes. The 2-D model has more realistic chemical, physical, and dynamical processes in the atmosphere and a relatively complete transport system, which makes it useful for a more accurate analysis. Furthermore, the University of Illinois at Urbana-Champaign (UIUC) radiative transfer model (RTM) is employed to derive the corresponding time-dependent radiative forcings from the 2-D CRT outputs. Two Halon compounds, Halon-1211 and Halon-1301, were selected to be studied for their indirect GWPs. The results showed that instantaneous and stratospheric adjusted indirect GWPs for a 100-year horizon are -10004.8 and -10237.1 for Halon-1211, while for Halon-1301 they are -19218.0 and -19627.6. The indirect GWPs for Halon-1211 and -1301 presented here are two to three times smaller compared to the results in WMO (2006) draft. Further analysis on indirect GWPs will be carried out using our 3-D MOZART-3 model.

  7. Reducing uncertainty of aerosol indirect effects using a joint satellite-reanalysis approach

    NASA Astrophysics Data System (ADS)

    Block, Karoline; Quaas, Johannes

    2015-04-01

    Aerosols are known to have a significant impact on cloud microphysics, acting as cloud condensation nuclei (CCN) and thereby altering cloud properties. Global estimates of indirect aerosol effects purely from satellites are very uncertain and often give insignificant results. To improve observationally based estimates we use a joint multi-component approach combining cloud retrievals from the A-Train satellite instruments and aerosol information from the MACC-II reanalysis. We show the ability of this approach to compute CCN and validate the results with insitu measurements. Furthermore we discuss the impact of these findings for computing cloud droplet numbers and cloud albedo to fill the gap in the chain leading to an accurate estimate of the first aerosol indirect radiative forcing.

  8. A Green's Function Approach to Simulate DNA Damage by the Indirect Effect

    NASA Technical Reports Server (NTRS)

    Plante, Ianik; Cicinotta, Francis A.

    2013-01-01

    The DNA damage is of fundamental importance in the understanding of the effects of ionizing radiation. DNA is damaged by the direct effect of radiation (e.g. direct ionization) and by indirect effect (e.g. damage by.OH radicals created by the radiolysis of water). Despite years of research, many questions on the DNA damage by ionizing radiation remains. In the recent years, the Green's functions of the diffusion equation (GFDE) have been used extensively in biochemistry [1], notably to simulate biochemical networks in time and space [2]. In our future work on DNA damage, we wish to use an approach based on the GFDE to refine existing models on the indirect effect of ionizing radiation on DNA. To do so, we will use the code RITRACKS [3] developed at the NASA Johnson Space Center to simulate the radiation track structure and calculate the position of radiolytic species after irradiation. We have also recently developed an efficient Monte-Carlo sampling algorithm for the GFDE of reversible reactions with an intermediate state [4], which can be modified and adapted to simulate DNA damage by free radicals. To do so, we will use the known reaction rate constants between radicals (OH, eaq, H,...) and the DNA bases, sugars and phosphates and use the sampling algorithms to simulate the diffusion of free radicals and chemical reactions with DNA. These techniques should help the understanding of the contribution of the indirect effect in the formation of DNA damage and double-strand breaks.

  9. An automated approach to the segmentation of HEp-2 cells for the indirect immunofluorescence ANA test.

    PubMed

    Tonti, Simone; Di Cataldo, Santa; Bottino, Andrea; Ficarra, Elisa

    2015-03-01

    The automatization of the analysis of Indirect Immunofluorescence (IIF) images is of paramount importance for the diagnosis of autoimmune diseases. This paper proposes a solution to one of the most challenging steps of this process, the segmentation of HEp-2 cells, through an adaptive marker-controlled watershed approach. Our algorithm automatically conforms the marker selection pipeline to the peculiar characteristics of the input image, hence it is able to cope with different fluorescent intensities and staining patterns without any a priori knowledge. Furthermore, it shows a reduced sensitivity to over-segmentation errors and uneven illumination, that are typical issues of IIF imaging.

  10. The laparoscopic approach for repair of indirect inguinal hernias in infants and children

    PubMed Central

    Juang, David; Fraser, Jason D.

    2016-01-01

    Repair of an indirect inguinal hernia is one of the most common operations performed around the world by pediatric surgeons. Until the last 15 years, most inguinal hernia repairs were performed using an inguinal crease incision and extraperitoneal ligation of the patent processes vaginalis. However, since 2000, the laparoscopic approach has gained popularity and there have been increasing descriptions about various techniques for laparoscopic hernia (LH) repair. At our institution, we have transitioned the majority of inguinal hernia repairs to the laparoscopic approach. In this article, we will describe the technique that is utilized at Children’s Mercy Hospital in Kansas City, Missouri (USA) and express our thoughts on the current debate regarding laparoscopic versus open inguinal hernia repair in infants and children. PMID:27867843

  11. Solution-focused approach therapy for mental health nursing students.

    PubMed

    Evans, Nicola; Evans, Anne-Marie

    Solution-focused therapy is a model of therapy that builds on the client's strengths, is future-focused and can be generally offered as a brief intervention. It can be used across multiple clinical settings and is not limited to being useful for clients accessing mental health services. Learning the underlying principles and developing a foundation level of skill in the approach was found to be achievable in an undergraduate nursing course, with students reporting an increase in their knowledge of the model and confidence in basic therapeutic skills in just one day of training. In this paper, we introduce the solution-focused approach in relation to nursing practice. We describe the template used for the training day offered to undergraduate mental health nurses. Students reported that this method of learning a therapeutic approach was helpful and increased both their knowledge and skill base.

  12. New Approach to Characterize the Configuration of Fractured Rock Surface Indirectly

    NASA Astrophysics Data System (ADS)

    Li, Ye Xue; Li, Zheng; Fan, Jian Hui; Jia, Zhi Yong

    2015-11-01

    A novel approach called the YUV dimension method is proposed in this study to indirectly characterize fractured rock surface topography. This model is based on YUV color model theory in iconography and graphics. The process is described in detail as follows. A true-color photo with m pixels is selected. Y is denoted by gray scale, U by hue, and V by the saturation components of the pixel color. These components are applied to create the z, x and y coordinates of the point in the coordinate system that originates from the pixel. A similar method is applied in each pixel. M points are created in the coordinate space. The number of created points is equivalent to one of the pixels. The m points are then connected and a rough YUV surface is established. Otherwise, the calculation method for the self-affine dimension of a n - 1 n-dimensional fractal body is presented by fractal Brownian motion theory and then degenerated to one between the 2D and 3D case. The approach is applied to evaluate the dimension of the YUV surface, i.e. the YUV dimension. To validate the feasibility of YUV dimension theory, numerical studies on the YUV dimension are conducted through a laser profilometer scanning experiment and scanning electron microscopy with the same specimens. The surface characteristics of similar samples are analyzed by probing into the YUV, general and grayscale dimensions of the specimens. The comparison shows that the YUV and general dimensions of similar specimens are fundamentally identical, and the complete trends of the YUV and gray dimensions remain consistent with changing specimens. The result indicates that YUV dimension theory is reasonable and feasible. In short, the YUV dimension is a new method that exhibits more advantages than the general and grayscale dimensions. This method characterizes surface configuration indirectly.

  13. Sound focusing in rooms: the time-reversal approach.

    PubMed

    Yon, Sylvain; Tanter, Mickael; Fink, Mathias

    2003-03-01

    New perspectives in audible range acoustics, such as virtual sound space creation and active noise control, rely on the ability of the rendering system to recreate precisely a desired sound field. This ability to control sound in a given volume of a room is directly linked to the capacity to focus acoustical energy both in space and time. However, sound focusing in rooms remains a complicated problem, essentially because of the multiple reflections on obstacles and walls occurring during propagation. In this paper, the technique of time-reversal focusing, well known in ultrasound, is experimentally applied to audible range acoustics. Compared to classical focusing techniques such as delay law focusing, time reversal appears to considerably improve quality of both temporal and spatial focusing. This so-called super-resolution phenomenon is due to the ability of time reversal to take into account all of the different sound paths between the emitting antenna and the focal point, thus creating an adaptive spatial and temporal matched filter for the considered propagation medium. Experiments emphasize the strong robustness of time-reversal focusing towards small modifications in the medium, such as people in motion or temperature variations. Sound focusing through walls using the time-reversal approach is also experimentally demonstrated.

  14. Focused Ubiquity: A Purposeful Approach to Providing Students with Laptops

    ERIC Educational Resources Information Center

    Keppler, Mike; Weiler, Spencer C.; Maas, Dan

    2014-01-01

    Laptops have been introduced into classroom across the nation as a way to improve teaching and learning. In 2007 Littleton Public Schools (LPS) introduced a focused approach to providing all students with a laptop at a significantly lower cost to the traditional ubiquitous laptop programs. The purpose of this study was to document the LPS model…

  15. Teachers' Perceptions of Bullying: A Focus Group Approach

    ERIC Educational Resources Information Center

    Rosen, Lisa H.; Scott, Shannon R.; DeOrnellas, Kathy

    2017-01-01

    The current qualitative study used a focus group approach to examine teachers' perceptions of student aggressors and victims. Participants in the current study included 35 teachers from public elementary, middle, and high schools. Teachers' responses to five questions about risk factors for aggression and victimization, adaptive and maladaptive…

  16. THE DUAL-FOCUS APPROACH TO CREATING BILINGUAL MEASURES

    PubMed Central

    ERKUT, SUMRU; ALARCÓN, ODETTE; GARCÍA COLL, CYNTHIA; TROPP, LINDA R.; GARCÍA, HEIDIE A. VÁZQUEZ

    2011-01-01

    The dual-focus approach to creating bilingual research protocols requires a bilingual/bicultural research team, including indigenous researchers from the cultures being studied. The presence of indigenous researchers as full and equal members of the research team can guard against an unexamined exportation of ideas and methods developed in one culture to other cultural/linguistic communities. The team develops the research plan and a research protocol that express a given concept with equal clarity, affect, and level of usage simultaneously in two languages. The dual-focus method employs a concept-driven rather than a translation-driven approach to attain conceptual and linguistic equivalence. Examples of the application of this approach to creating new measures in Spanish and English, adapting existing measures, revising instructions to research participants, and correcting official translations are provided. PMID:21552397

  17. Teaching the Indirect Method of the Statement of Cash Flows in Introductory Financial Accounting: A Comprehensive, Problem-Based Approach

    ERIC Educational Resources Information Center

    Brickner, Daniel R.; McCombs, Gary B.

    2004-01-01

    In this article, the authors provide an instructional resource for presenting the indirect method of the statement of cash flows (SCF) in an introductory financial accounting course. The authors focus primarily on presenting a comprehensive example that illustrates the "why" of SCF preparation and show how journal entries and T-accounts can be…

  18. Alternative Approaches for Measuring Values: Direct and Indirect Assessments in Performance Prediction.

    ERIC Educational Resources Information Center

    Mumford, Michael D.; Connelly, Mary Shane; Helton, Whitney B.; Van Doorn, Judy R.; Osburn, Holly K.

    2002-01-01

    Undergraduates (n=195) completed direct and indirect measures of values before working on entrepreneurial, consulting, and marketing tasks. Regression analysis showed both types of measures were effective predictors. Indirect measures yielded better prediction and better discrimination of cross-task performance differences. (Contains 55…

  19. Indirect composite resin crowns as an esthetic approach to treating ectodermal dysplasia: a case report.

    PubMed

    Ellis, R K; Donly, K J; Wild, T W

    1992-11-01

    This article presents a case report describing the indirect fabrication of composite resin crowns for the restoration of primary anterior teeth. A 3-year-old with a confirmed diagnosis of hypohidrotic ectodermal dysplasia was provided with composite resin crowns that were both esthetic and functional. The indirect method decreases clinical time, provides a durable restoration, and allows treatment of patients who lack the cooperative ability to endure prolonged direct bonding appointments. The indirect technique may be feasible for the restoration of carious teeth as well as the presented case.

  20. Solution focused teaching: a transformative approach to teaching nursing.

    PubMed

    McAllister, Margaret; Venturato, Lorraine; Johnston, Amy; Rowe, Jennifer; Tower, Marion; Moyle, Wendy

    2006-01-01

    Nurses work in complex health care systems, which today are based not only on medical treatment and cure, but also on enabling individuals and strengthening communities. This paper describes a curriculum approach to teaching nursing in an Australian university which seeks to prepare students for this environment. Underpinned by transformative education principles, and termed Solution Focused Nursing, specific teaching and learning strategies are discussed. A goal is to cultivate critical thinkers and knowledge workers, that is, nurses who are not only able to work skillfully, strategically, and respectfully with clients, but who also demonstrate discernment, optimism, and vision about nursing and health care.

  1. Direct vs. Indirect Moral Enhancement.

    PubMed

    Schaefer, G Owen

    2015-09-01

    Moral enhancement is an ostensibly laudable project. Who wouldn't want people to become more moral? Still, the project's approach is crucial. We can distinguish between two approaches for moral enhancement: direct and indirect. Direct moral enhancements aim at bringing about particular ideas, motives or behaviors. Indirect moral enhancements, by contrast, aim at making people more reliably produce the morally correct ideas, motives or behaviors without committing to the content of those ideas, motives and/or actions. I will argue, on Millian grounds, that the value of disagreement puts serious pressure on proposals for relatively widespread direct moral enhancement. A more acceptable path would be to focus instead on indirect moral enhancements while staying neutral, for the most part, on a wide range of substantive moral claims. I will outline what such indirect moral enhancement might look like, and why we should expect it to lead to general moral improvement.

  2. Inertial fusion energy development approaches for direct and indirect-drive

    SciTech Connect

    Logan, B.G.; Lindl, J.D.; Meier, W.R.

    1996-08-20

    Consideration of different driver and target requirements for inertial fusion energy (IFE) power plants together with the potential energy gains of direct and indirect-drive targets leads to different optimal combinations of driver and target options for each type of target. In addition, different fusion chamber concepts are likely to be most compatible with these different driver and target combinations. For example, heavy-ion drivers appear to be well matched to indirect=drive targets with all-liquid-protected-wall chambers requiring two-sided illuminations, while diode-pumped, solid- state laser drivers are better matched to direct-drive targets with chambers using solid walls or flow-guiding structures to allow spherically symmetric illuminations. R&D on the critical issues of drivers, targets, and chambers for both direct and indirect-drive options should be pursued until the ultimate gain of either type of target for IFE is better understood.

  3. Determining Cross Sections for Reactions on Unstable Nuclei: A Consideration of Indirect Approaches

    SciTech Connect

    Escher, J.; Dietrich, F.S.

    2005-10-14

    An indirect method for determining cross sections for reactions proceeding through a compound nucleus is presented. The appropriate theoretical framework for applications of this method is reviewed and theoretical and experimental challenges that need to be addressed in applications of the method are outlined. Two approximations are considered and their advantages and limitations are discussed.

  4. Determining Cross Sections for Reactions on Unstable Nuclei: A Consideration of Indirect Approaches

    SciTech Connect

    Escher, J; Dietrich, F S

    2005-05-24

    An indirect method for determining cross sections for reactions proceeding through a compound nucleus is presented. The appropriate theoretical framework for applications of this method is reviewed and theoretical and experimental challenges that need to be addressed in applications of the method are outlined. Two approximations are considered and their advantages and limitations are discussed.

  5. Regional economic activity and absenteeism: a new approach to estimating the indirect costs of employee productivity loss.

    PubMed

    Bankert, Brian; Coberley, Carter; Pope, James E; Wells, Aaron

    2015-02-01

    This paper presents a new approach to estimating the indirect costs of health-related absenteeism. Productivity losses related to employee absenteeism have negative business implications for employers and these losses effectively deprive the business of an expected level of employee labor. The approach herein quantifies absenteeism cost using an output per labor hour-based method and extends employer-level results to the region. This new approach was applied to the employed population of 3 health insurance carriers. The economic cost of absenteeism was estimated to be $6.8 million, $0.8 million, and $0.7 million on average for the 3 employers; regional losses were roughly twice the magnitude of employer-specific losses. The new approach suggests that costs related to absenteeism for high output per labor hour industries exceed similar estimates derived from application of the human capital approach. The materially higher costs under the new approach emphasize the importance of accurately estimating productivity losses.

  6. Separating direct and indirect effects of global change: a population dynamic modeling approach using readily available field data.

    PubMed

    Farrer, Emily C; Ashton, Isabel W; Knape, Jonas; Suding, Katharine N

    2014-04-01

    Two sources of complexity make predicting plant community response to global change particularly challenging. First, realistic global change scenarios involve multiple drivers of environmental change that can interact with one another to produce non-additive effects. Second, in addition to these direct effects, global change drivers can indirectly affect plants by modifying species interactions. In order to tackle both of these challenges, we propose a novel population modeling approach, requiring only measurements of abundance and climate over time. To demonstrate the applicability of this approach, we model population dynamics of eight abundant plant species in a multifactorial global change experiment in alpine tundra where we manipulated nitrogen, precipitation, and temperature over 7 years. We test whether indirect and interactive effects are important to population dynamics and whether explicitly incorporating species interactions can change predictions when models are forecast under future climate change scenarios. For three of the eight species, population dynamics were best explained by direct effect models, for one species neither direct nor indirect effects were important, and for the other four species indirect effects mattered. Overall, global change had negative effects on species population growth, although species responded to different global change drivers, and single-factor effects were slightly more common than interactive direct effects. When the fitted population dynamic models were extrapolated under changing climatic conditions to the end of the century, forecasts of community dynamics and diversity loss were largely similar using direct effect models that do not explicitly incorporate species interactions or best-fit models; however, inclusion of species interactions was important in refining the predictions for two of the species. The modeling approach proposed here is a powerful way of analyzing readily available datasets which should be

  7. New Modeling Approaches to Study DNA Damage by the Direct and Indirect Effects of Ionizing Radiation

    NASA Technical Reports Server (NTRS)

    Plante, Ianik; Cucinotta, Francis A.

    2012-01-01

    DNA is damaged both by the direct and indirect effects of radiation. In the direct effect, the DNA itself is ionized, whereas the indirect effect involves the radiolysis of the water molecules surrounding the DNA and the subsequent reaction of the DNA with radical products. While this problem has been studied for many years, many unknowns still exist. To study this problem, we have developed the computer code RITRACKS [1], which simulates the radiation track structure for heavy ions and electrons, calculating all energy deposition events and the coordinates of all species produced by the water radiolysis. In this work, we plan to simulate DNA damage by using the crystal structure of a nucleosome and calculations performed by RITRACKS. The energy deposition events are used to calculate the dose deposited in nanovolumes [2] and therefore can be used to simulate the direct effect of the radiation. Using the positions of the radiolytic species with a radiation chemistry code [3] it will be possible to simulate DNA damage by indirect effect. The simulation results can be compared with results from previous calculations such as the frequencies of simple and complex strand breaks [4] and with newer experimental data using surrogate markers of DNA double ]strand breaks such as . ]H2AX foci [5].

  8. A Quasi-Dynamic Approach to modelling Hydrodynamic Focusing

    NASA Astrophysics Data System (ADS)

    Kommajosula, Aditya; Xu, Songzhe; Wu, Chueh-Yu; di Carlo, Dino; Ganapathysubramanian, Baskar; ComPM Lab Team; Di Carlo Lab Collaboration

    2016-11-01

    We examine a particle's tendency at different spatial locations to shift/rotate towards the equilibrium location, by constrained simulation. Although studies in the past have used this procedure in conjunction with FSI methods to great effect, the current work in 2D explores an alternative approach by utilizing a modified trust-region-based root-finding algorithm to solve for particle position and velocities at equilibrium, using "snapshots" of finite-element solutions to the steady-state Navier-Stokes equations iteratively over a computational domain attached to the particle reference frame. Through an assortment of test cases comprising circular and non-circular particle geometries, an incorporation of stability theory as applicable to dynamical systems is demonstrated, to locate the final focusing location and velocities. The results are compared with previous experimental/numerical reports, and found to be in close agreement. A thousand-fold increase is observed in computational time for the current workflow from its transient counterpart, for an illustrative case. The current framework is formulated in 2D for 3 Degrees-of-Freedom, and will be extended to 3D. This framework potentially allows for quick, high-throughput parametric space studies of equilibrium scaling laws.

  9. Evaluation of direct and indirect ethanol biomarkers using a likelihood ratio approach to identify chronic alcohol abusers for forensic purposes.

    PubMed

    Alladio, Eugenio; Martyna, Agnieszka; Salomone, Alberto; Pirro, Valentina; Vincenti, Marco; Zadora, Grzegorz

    2017-02-01

    The detection of direct ethanol metabolites, such as ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs), in scalp hair is considered the optimal strategy to effectively recognize chronic alcohol misuses by means of specific cut-offs suggested by the Society of Hair Testing. However, several factors (e.g. hair treatments) may alter the correlation between alcohol intake and biomarkers concentrations, possibly introducing bias in the interpretative process and conclusions. 125 subjects with various drinking habits were subjected to blood and hair sampling to determine indirect (e.g. CDT) and direct alcohol biomarkers. The overall data were investigated using several multivariate statistical methods. A likelihood ratio (LR) approach was used for the first time to provide predictive models for the diagnosis of alcohol abuse, based on different combinations of direct and indirect alcohol biomarkers. LR strategies provide a more robust outcome than the plain comparison with cut-off values, where tiny changes in the analytical results can lead to dramatic divergence in the way they are interpreted. An LR model combining EtG and FAEEs hair concentrations proved to discriminate non-chronic from chronic consumers with ideal correct classification rates, whereas the contribution of indirect biomarkers proved to be negligible. Optimal results were observed using a novel approach that associates LR methods with multivariate statistics. In particular, the combination of LR approach with either Principal Component Analysis (PCA) or Linear Discriminant Analysis (LDA) proved successful in discriminating chronic from non-chronic alcohol drinkers. These LR models were subsequently tested on an independent dataset of 43 individuals, which confirmed their high efficiency. These models proved to be less prone to bias than EtG and FAEEs independently considered. In conclusion, LR models may represent an efficient strategy to sustain the diagnosis of chronic alcohol consumption

  10. Hazard and risk assessment for indirect potable reuse schemes: An approach for use in developing Water Safety Plans.

    PubMed

    Dominguez-Chicas, Angelina; Scrimshaw, Mark D

    2010-12-01

    This paper describes research undertaken to develop an approach for facilitating an initial hazard assessment and risk characterisation for a proposed indirect potable reuse scheme, as part of the water safety plan recommended by the World Health Organization. The process involved a description and evaluation of the catchment, which was the sewerage system supplying the sewage treatment works that would provide the effluent to supply the pilot scale indirect potable reuse water treatment plant. Hazards, sources and barriers throughout the proposed system were identified and evaluated. An initial assessment of the possible hazards, highlighted chemical hazards as predominating, and assessment of risks, using a heat map as output, categorised most hazards as medium or high risk. However, this outcome has been influenced by a precautionary approach which assigned a high likelihood to the occurrence of hazards where no data was available on their occurrence in the system. As more data becomes available, and the waster safety plan develops, it is anticipated that the risk heat map will become more specific. Additionally, high quality targets, to drinking water standards, have been set, although water from the potable reuse plant will be discharged to receiving waters where it will undergo natural attenuation prior to further treatment to potable standards before distribution. The assessment has demonstrated the usefulness of the approach where data is initially limited, in generating a heat map allowing for prioritisation of hazards to a practical level.

  11. Effective Student Focus Groups: The Bright and Early Approach.

    ERIC Educational Resources Information Center

    Gowdy, E. Alana

    1996-01-01

    At Mount Royal College (Alberta), the perceptions of enrolled college students are seen as an important part of academic program review, but identification of appropriate scheduling of meetings may be difficult. The solution found was to obtain faculty assistance in selecting students and to schedule focus groups as breakfast meetings, which…

  12. Family Based Services: A Solution-Focused Approach.

    ERIC Educational Resources Information Center

    Berg, Insoo Kim

    Drawing on the field of family therapy, this step-by-step guide applies principles of brief, solution-focused therapy to family-based services (FBS) in ways that empower clients, increase cooperation, and aid the survival of social workers. Based on the author's experience at the Brief Family Therapy Center in Milwaukee, Wisconsin, the book is…

  13. Individualized Child-Focused Curriculum: A Differentiated Approach

    ERIC Educational Resources Information Center

    Gronlund, Gaye

    2016-01-01

    How do you focus on each individual child in a full classroom? Learn to integrate individualized curriculum into daily practice with this step-­by-­step guide. Even good observers and documenters do not always use these insights to inform their curriculum planning. Using Developmental Studies, a new tool created and successfully field­-tested by…

  14. A Comparison of Three Approaches to Correct for Direct and Indirect Range Restrictions: A Simulation Study

    ERIC Educational Resources Information Center

    Pfaffel, Andreas; Schober, Barbara; Spiel, Christiane

    2016-01-01

    A common methodological problem in the evaluation of the predictive validity of selection methods, e.g. in educational and employment selection, is that the correlation between predictor and criterion is biased. Thorndike's (1949) formulas are commonly used to correct for this biased correlation. An alternative approach is to view the selection…

  15. The indirect nature of social motives: the relation of social approach and avoidance motives with likeability via extraversion and agreeableness.

    PubMed

    Nikitin, Jana; Freund, Alexandra M

    2015-02-01

    The current study tested assumptions derived from the whole-trait theory (Fleeson, 2012), which proposes a connection between personality and motivation. We hypothesized that individual differences in social approach and avoidance motives are associated with personality as observed by others. In addition, we expected that observed personality links social approach and avoidance motives to interpersonal outcomes. The sample was composed of 83 young adults (25.3% males, Mage  = 21.66 years) who had recently moved into a shared apartment. Roommates (N = 83; 50.6% males, Mage  = 22.83 years) evaluated the newcomers on Extraversion, Agreeableness, and likeability. Approach motives had an indirect positive effect on likeability through other-reported Extraversion and Agreeableness. Although avoidance motives had some negative effects on likeability mediated through low Extraversion, they were positively associated with Agreeableness. These results demonstrate the complexity of social approach and avoidance motives. Moreover, they highlight the importance of motivational factors for observed personality.

  16. Strengthening the Focus on Business Results: The Need for Systems Approaches in Organizational Behavior Management

    ERIC Educational Resources Information Center

    Hyten, Cloyd

    2009-01-01

    Current Organizational Behavior Management (OBM) research and practice may be characterized as either behavior focused or results focused. These two approaches stem from different origins and have different characteristics. The behavior-focused approach stems from applied behavior analysis (ABA) methods and emphasizes direct observation of and…

  17. Indirection and computer security.

    SciTech Connect

    Berg, Michael J.

    2011-09-01

    The discipline of computer science is built on indirection. David Wheeler famously said, 'All problems in computer science can be solved by another layer of indirection. But that usually will create another problem'. We propose that every computer security vulnerability is yet another problem created by the indirections in system designs and that focusing on the indirections involved is a better way to design, evaluate, and compare security solutions. We are not proposing that indirection be avoided when solving problems, but that understanding the relationships between indirections and vulnerabilities is key to securing computer systems. Using this perspective, we analyze common vulnerabilities that plague our computer systems, consider the effectiveness of currently available security solutions, and propose several new security solutions.

  18. Rapid determination of enantiomeric excess: a focus on optical approaches.

    PubMed

    Leung, Diana; Kang, Sung Ok; Anslyn, Eric V

    2012-01-07

    High-throughput screening (HTS) methods are becoming increasingly essential in discovering chiral catalysts or auxiliaries for asymmetric transformations due to the advent of parallel synthesis and combinatorial chemistry. Both parallel synthesis and combinatorial chemistry can lead to the exploration of a range of structural candidates and reaction conditions as a means to obtain the highest enantiomeric excess (ee) of a desired transformation. One current bottleneck in these approaches to asymmetric reactions is the determination of ee, which has led researchers to explore a wide range of HTS techniques. To be truly high-throughput, it has been proposed that a technique that can analyse a thousand or more samples per day is needed. Many of the current approaches to this goal are based on optical methods because they allow for a rapid determination of ee due to quick data collection and their parallel analysis capabilities. In this critical review these techniques are reviewed with a discussion of their respective advantages and drawbacks, and with a contrast to chromatographic methods (180 references).

  19. Session Two Outcome of the Formula First Session Task in Problem- and Solution-Focused Approaches.

    ERIC Educational Resources Information Center

    Jordan, Karin; Quinn, William H.

    1994-01-01

    Evaluated treatment effects in single session process using problem-focused approach and solution-focused approach. Findings indicated significant difference between two approaches when dealing with client's perceived problem improvement, outcome expectancy, session depth, session smoothness, and session positivity. Found no significant…

  20. A Practical Approach to Excessive Daytime Sleepiness: A Focused Review.

    PubMed

    Murray, Brian J

    2016-01-01

    Excessive daytime sleepiness (EDS) is a common problem that is important to recognize and address. Initial steps in management are generally straightforward and only the most advanced cases would require referral to a subspecialist. Of particular concern is that of driving safety. There is a broad differential diagnosis for conditions contributing to EDS but a few common conditions account for the majority of clinical presentations. Subjective self-reporting will often lead to identification of potential problems, but this is often unreliable. Traditional neurophysiologic tests can help in objectively quantifying symptoms but current tests are not always practical clinically and may have little validation in real world situations. There are many treatment options that should generally be able to sufficiently manage most patients presenting with hypersomnolence. This review provides a practical clinical approach to the problem based on current guidelines.

  1. Food Composition Database Format and Structure: A User Focused Approach

    PubMed Central

    Clancy, Annabel K.; Woods, Kaitlyn; McMahon, Anne; Probst, Yasmine

    2015-01-01

    This study aimed to investigate the needs of Australian food composition database user’s regarding database format and relate this to the format of databases available globally. Three semi structured synchronous online focus groups (M = 3, F = 11) and n = 6 female key informant interviews were recorded. Beliefs surrounding the use, training, understanding, benefits and limitations of food composition data and databases were explored. Verbatim transcriptions underwent preliminary coding followed by thematic analysis with NVivo qualitative analysis software to extract the final themes. Schematic analysis was applied to the final themes related to database format. Desktop analysis also examined the format of six key globally available databases. 24 dominant themes were established, of which five related to format; database use, food classification, framework, accessibility and availability, and data derivation. Desktop analysis revealed that food classification systems varied considerably between databases. Microsoft Excel was a common file format used in all databases, and available software varied between countries. User’s also recognised that food composition databases format should ideally be designed specifically for the intended use, have a user-friendly food classification system, incorporate accurate data with clear explanation of data derivation and feature user input. However, such databases are limited by data availability and resources. Further exploration of data sharing options should be considered. Furthermore, user’s understanding of food composition data and databases limitations is inherent to the correct application of non-specific databases. Therefore, further exploration of user FCDB training should also be considered. PMID:26554836

  2. Introduction to Focus Issue: Quantitative Approaches to Genetic Networks

    NASA Astrophysics Data System (ADS)

    Albert, Réka; Collins, James J.; Glass, Leon

    2013-06-01

    All cells of living organisms contain similar genetic instructions encoded in the organism's DNA. In any particular cell, the control of the expression of each different gene is regulated, in part, by binding of molecular complexes to specific regions of the DNA. The molecular complexes are composed of protein molecules, called transcription factors, combined with various other molecules such as hormones and drugs. Since transcription factors are coded by genes, cellular function is partially determined by genetic networks. Recent research is making large strides to understand both the structure and the function of these networks. Further, the emerging discipline of synthetic biology is engineering novel gene circuits with specific dynamic properties to advance both basic science and potential practical applications. Although there is not yet a universally accepted mathematical framework for studying the properties of genetic networks, the strong analogies between the activation and inhibition of gene expression and electric circuits suggest frameworks based on logical switching circuits. This focus issue provides a selection of papers reflecting current research directions in the quantitative analysis of genetic networks. The work extends from molecular models for the binding of proteins, to realistic detailed models of cellular metabolism. Between these extremes are simplified models in which genetic dynamics are modeled using classical methods of systems engineering, Boolean switching networks, differential equations that are continuous analogues of Boolean switching networks, and differential equations in which control is based on power law functions. The mathematical techniques are applied to study: (i) naturally occurring gene networks in living organisms including: cyanobacteria, Mycoplasma genitalium, fruit flies, immune cells in mammals; (ii) synthetic gene circuits in Escherichia coli and yeast; and (iii) electronic circuits modeling genetic networks

  3. Introduction to focus issue: quantitative approaches to genetic networks.

    PubMed

    Albert, Réka; Collins, James J; Glass, Leon

    2013-06-01

    All cells of living organisms contain similar genetic instructions encoded in the organism's DNA. In any particular cell, the control of the expression of each different gene is regulated, in part, by binding of molecular complexes to specific regions of the DNA. The molecular complexes are composed of protein molecules, called transcription factors, combined with various other molecules such as hormones and drugs. Since transcription factors are coded by genes, cellular function is partially determined by genetic networks. Recent research is making large strides to understand both the structure and the function of these networks. Further, the emerging discipline of synthetic biology is engineering novel gene circuits with specific dynamic properties to advance both basic science and potential practical applications. Although there is not yet a universally accepted mathematical framework for studying the properties of genetic networks, the strong analogies between the activation and inhibition of gene expression and electric circuits suggest frameworks based on logical switching circuits. This focus issue provides a selection of papers reflecting current research directions in the quantitative analysis of genetic networks. The work extends from molecular models for the binding of proteins, to realistic detailed models of cellular metabolism. Between these extremes are simplified models in which genetic dynamics are modeled using classical methods of systems engineering, Boolean switching networks, differential equations that are continuous analogues of Boolean switching networks, and differential equations in which control is based on power law functions. The mathematical techniques are applied to study: (i) naturally occurring gene networks in living organisms including: cyanobacteria, Mycoplasma genitalium, fruit flies, immune cells in mammals; (ii) synthetic gene circuits in Escherichia coli and yeast; and (iii) electronic circuits modeling genetic networks

  4. The Direct and Indirect Effect of Motivation for Learning on Students' Approaches to Learning through the Perceptions of Workload and Task Complexity

    ERIC Educational Resources Information Center

    Kyndt, Eva; Dochy, Filip; Struyven, Katrien; Cascallar, Eduardo

    2011-01-01

    The present study investigates the direct and indirect influence of motivation for learning, as understood by the self-determination theory, on students' approaches to learning. Concerning the direct influence of motivation, results show that autonomous motivation is positively related to a deep approach to learning and negatively to a surface…

  5. A Missing Data Approach to Correct for Direct and Indirect Range Restrictions with a Dichotomous Criterion: A Simulation Study

    PubMed Central

    Pfaffel, Andreas; Kollmayer, Marlene; Schober, Barbara; Spiel, Christiane

    2016-01-01

    A recurring methodological problem in the evaluation of the predictive validity of selection methods is that the values of the criterion variable are available for selected applicants only. This so-called range restriction problem causes biased population estimates. Correction methods for direct and indirect range restriction scenarios have widely studied for continuous criterion variables but not for dichotomous ones. The few existing approaches are inapplicable because they do not consider the unknown base rate of success. Hence, there is a lack of scientific research on suitable correction methods and the systematic analysis of their accuracies in the cases of a naturally or artificially dichotomous criterion. We aim to overcome this deficiency by viewing the range restriction problem as a missing data mechanism. We used multiple imputation by chained equations to generate complete criterion data before estimating the predictive validity and the base rate of success. Monte Carlo simulations were conducted to investigate the accuracy of the proposed correction in dependence of selection ratio, predictive validity, and base rate of success in an experimental design. In addition, we compared our proposed missing data approach with Thorndike’s well-known correction formulas that have only been used in the case of continuous criterion variables so far. The results show that the missing data approach is more accurate in estimating the predictive validity than Thorndike’s correction formulas. The accuracy of our proposed correction increases as the selection ratio and the correlation between predictor and criterion increase. Furthermore, the missing data approach provides a valid estimate of the unknown base rate of success. On the basis of our findings, we argue for the use of multiple imputation by chained equations in the evaluation of the predictive validity of selection methods when the criterion is dichotomous. PMID:27019277

  6. Teacher and Student-Focused Approaches: Influence of Learning Approach and Self-Efficacy in a Psychology Postgraduate Sample

    ERIC Educational Resources Information Center

    Kaye, Linda K.; Brewer, Gayle

    2013-01-01

    The current study examined approaches to teaching in a postgraduate psychology sample. This included considering teaching-focused (information transfer) and student-focused (conceptual changes in understanding) approaches to teaching. Postgraduate teachers of psychology (N = 113) completed a questionnaire measuring their use of a teacher- or…

  7. Applying Form-Focused Approaches to L2 Vocabulary Instruction through Video Podcasts

    ERIC Educational Resources Information Center

    Marefat, Fahimeh; Hassanzadeh, Mohammad

    2016-01-01

    Since its inception, form-focused instruction (FFI) has been associated with grammar, with only a handful of studies examining its potential for vocabulary development (e.g., Laufer, 2006). Meanwhile, there has been an unresolved dispute between the two approaches of Focus on Form (FonF) and Focus on Forms (FonFs) in terms of their degree of…

  8. From Nonlinear Optimization to Convex Optimization through Firefly Algorithm and Indirect Approach with Applications to CAD/CAM

    PubMed Central

    Gálvez, Akemi; Iglesias, Andrés

    2013-01-01

    Fitting spline curves to data points is a very important issue in many applied fields. It is also challenging, because these curves typically depend on many continuous variables in a highly interrelated nonlinear way. In general, it is not possible to compute these parameters analytically, so the problem is formulated as a continuous nonlinear optimization problem, for which traditional optimization techniques usually fail. This paper presents a new bioinspired method to tackle this issue. In this method, optimization is performed through a combination of two techniques. Firstly, we apply the indirect approach to the knots, in which they are not initially the subject of optimization but precomputed with a coarse approximation scheme. Secondly, a powerful bioinspired metaheuristic technique, the firefly algorithm, is applied to optimization of data parameterization; then, the knot vector is refined by using De Boor's method, thus yielding a better approximation to the optimal knot vector. This scheme converts the original nonlinear continuous optimization problem into a convex optimization problem, solved by singular value decomposition. Our method is applied to some illustrative real-world examples from the CAD/CAM field. Our experimental results show that the proposed scheme can solve the original continuous nonlinear optimization problem very efficiently. PMID:24376380

  9. Indirect radio-chemo-beta therapy: a targeted approach to increase biological efficiency of x-rays based on energy

    NASA Astrophysics Data System (ADS)

    Oktaria, Sianne; Corde, Stéphanie; Lerch, Michael L. F.; Konstantinov, Konstantin; Rosenfeld, Anatoly B.; Tehei, Moeava

    2015-10-01

    Despite the use of multimodal treatments incorporating surgery, chemotherapy and radiotherapy, local control of gliomas remains a major challenge. The potential of a new treatment approach called indirect radio-chemo-beta therapy using the synergy created by combining methotrexate (MTX) with bromodeoxyuridine (BrUdR) under optimum energy x-ray irradiation is assessed. 9L rat gliosarcoma cells pre-treated with 0.01 μM MTX and/or 10 μM BrUdR were irradiated in vitro with 50 kVp, 125 kVp, 250 kVp, 6 MV and 10 MV x-rays. The cytotoxicity was assessed using clonogenic survival as the radiobiological endpoint. The photon energy with maximum effect was determined using radiation sensitization enhancement factors at 10% clonogenic survival (SER10%). The cell cycle distribution was investigated using flow cytometric analysis with propidium iodide staining. Incorporation of BrUdR in the DNA was detected by the fluorescence of labelled anti-BrUdR antibodies. The radiation sensitization enhancement exhibits energy dependence with a maximum of 2.3 at 125 kVp for the combined drug treated cells. At this energy, the shape of the clonogenic survival curve of the pharmacological agents treated cells changes substantially. This change is interpreted as an increased lethality of the local radiation environment and is attributed to supplemented inhibition of DNA repair. Radiation induced chemo-beta therapy was demonstrated in vitro by the targeted activation of combined pharmacological agents with optimized energy tuning of x-ray beams on 9 L cells. Our results show that this is a highly effective form of chemo-radiation therapy.

  10. Indirect radio-chemo-beta therapy: a targeted approach to increase biological efficiency of x-rays based on energy.

    PubMed

    Oktaria, Sianne; Corde, Stéphanie; Lerch, Michael L F; Konstantinov, Konstantin; Rosenfeld, Anatoly B; Tehei, Moeava

    2015-10-21

    Despite the use of multimodal treatments incorporating surgery, chemotherapy and radiotherapy, local control of gliomas remains a major challenge. The potential of a new treatment approach called indirect radio-chemo-beta therapy using the synergy created by combining methotrexate (MTX) with bromodeoxyuridine (BrUdR) under optimum energy x-ray irradiation is assessed. 9L rat gliosarcoma cells pre-treated with 0.01 μM MTX and/or 10 μM BrUdR were irradiated in vitro with 50 kVp, 125 kVp, 250 kVp, 6 MV and 10 MV x-rays. The cytotoxicity was assessed using clonogenic survival as the radiobiological endpoint. The photon energy with maximum effect was determined using radiation sensitization enhancement factors at 10% clonogenic survival (SER10%). The cell cycle distribution was investigated using flow cytometric analysis with propidium iodide staining. Incorporation of BrUdR in the DNA was detected by the fluorescence of labelled anti-BrUdR antibodies. The radiation sensitization enhancement exhibits energy dependence with a maximum of 2.3 at 125 kVp for the combined drug treated cells. At this energy, the shape of the clonogenic survival curve of the pharmacological agents treated cells changes substantially. This change is interpreted as an increased lethality of the local radiation environment and is attributed to supplemented inhibition of DNA repair. Radiation induced chemo-beta therapy was demonstrated in vitro by the targeted activation of combined pharmacological agents with optimized energy tuning of x-ray beams on 9 L cells. Our results show that this is a highly effective form of chemo-radiation therapy.

  11. Extending the Use of Constructivist Approaches in Career Guidance and Counselling: Solution-Focused Strategies

    ERIC Educational Resources Information Center

    Miller, Judi H.

    2004-01-01

    This article focuses on the use of constructivist approaches by career counsellors. A three phase solution-focused model is presented that will enable career counselling practitioners to use brief, positively oriented strategies in an integrated manner with their clients. In addition, possible ways counsellors might integrate systems thinking in…

  12. New approaches in the indirect quantification of thermal rock properties in sedimentary basins: the well-log perspective

    NASA Astrophysics Data System (ADS)

    Fuchs, Sven; Balling, Niels; Förster, Andrea

    2016-04-01

    Numerical temperature models generated for geodynamic studies as well as for geothermal energy solutions heavily depend on rock thermal properties. Best practice for the determination of those parameters is the measurement of rock samples in the laboratory. Given the necessity to enlarge databases of subsurface rock parameters beyond drill core measurements an approach for the indirect determination of these parameters is developed, for rocks as well a for geological formations. We present new and universally applicable prediction equations for thermal conductivity, thermal diffusivity and specific heat capacity in sedimentary rocks derived from data provided by standard geophysical well logs. The approach is based on a data set of synthetic sedimentary rocks (clastic rocks, carbonates and evaporates) composed of mineral assemblages with variable contents of 15 major rock-forming minerals and porosities varying between 0 and 30%. Petrophysical properties are assigned to both the rock-forming minerals and the pore-filling fluids. Using multivariate statistics, relationships then were explored between each thermal property and well-logged petrophysical parameters (density, sonic interval transit time, hydrogen index, volume fraction of shale and photoelectric absorption index) on a regression sub set of data (70% of data) (Fuchs et al., 2015). Prediction quality was quantified on the remaining test sub set (30% of data). The combination of three to five well-log parameters results in predictions on the order of <15% for thermal conductivity and thermal diffusivity, and of <10% for specific heat capacity. Comparison of predicted and benchmark laboratory thermal conductivity from deep boreholes of the Norwegian-Danish Basin, the North German Basin, and the Molasse Basin results in 3 to 5% larger uncertainties with regard to the test data set. With regard to temperature models, the use of calculated TC borehole profiles approximate measured temperature logs with an

  13. Assessing the contents of polycyclic aromatic hydrocarbons in the tollbooths of a highway toll station via direct and indirect approaches.

    PubMed

    Tsai, Perng-Jy; Shih, Tung-Sheng; Chen, Hsiao-Lung; Lee, Wen-Jhy; Lai, Ching-Huang; Liou, Saou-Hsing

    2002-11-15

    The present study was set out to assess the contents of polycyclic aromatic hydrocarbons (PAHs) in three types of tollbooths at a highway toll station via direct and indirect approaches. Direct sampling results show that no significant difference could be found in the PAH homologue distributions for samples collected from the car lane/ticket-payment and car lane/cash-payment tollbooths, but both were significantly different from that for the bus/ truck lane tollbooth. The above results could be due to the former two types of tollbooths that were designed for the same type of traffic (i.e., cars and vans), but the latter was designed for a different type of traffic (i.e., buses and trucks). For any given type of tollbooth, the total-PAH content (C(Total-PAHs)) found during the day shift (= 9,370-15,500 ng/m3) were not significantly different from that found during the night shift (= 9,550-14,900 ng/m3), but both were significantly higher than that found during the late-night shift (= 5,560-11,100 ng/m3). During any given work shift we found C(Total-PAH5) for the three types of tollbooths as the following: bus/truck lane (= 11,100-15,500 ng/m3) > car lane/ticket-payment (= 7,260-13,500 ng/m3) > car lane/ cash-payment (= 5,560-9,550 ng/m3). After conducting multivariate regression analyses, we found that none of the three environmental factors (i.e., wind speed,temperature, and relative humidity), except for the vehicle flow rate (Q(Vehicle)) had a significant effect on C(Total-PAHs) for any given type of tollbooth. Considering directly measuring PAH contents was labor-consuming and costly, and the above results suggest the possibility of using Q(Vehicle) to predict C(Total-PAHs) for any given type of tollbooth. After conducting simple linear regression analyses, we found that (1) all resultant regression coefficients were found with positive values indicating that an increase in the Q(Vehicle) would lead to an increase in the C(Total-PHHs). (2) from the magnitude of

  14. An Integrated Approach for Strategic Development of Engineering Curricula: Focus on Students' Design Skills

    ERIC Educational Resources Information Center

    Rehman, H.-u.; Said, R. A.; Al-assaf, Y.

    2009-01-01

    This paper proposes an integrated approach for developing the engineering curricula with a specific focus on engineering design. The proposed approach allows a continuous and coherent development of engineering students' design skills throughout the entire undergraduate curriculum. This ongoing design experience is delivered at an involvement and…

  15. Comparison of Integrated Systemic and Emotionally Focused Approaches to Couples Therapy.

    ERIC Educational Resources Information Center

    Goldman, A.; Greenberg, L.

    1992-01-01

    Compared couples receiving 2 marital therapy approaches and control group over 10-week treatment period. Integrated systemic therapy (IST) and emotionally focused approach (EFT) both were found to be superior to control and to be equally effective in alleviating marital distress, facilitating conflict resolution and goal attainment, and reducing…

  16. Family-focused autism spectrum disorder research: a review of the utility of family systems approaches.

    PubMed

    Cridland, Elizabeth K; Jones, Sandra C; Magee, Christopher A; Caputi, Peter

    2014-04-01

    A family member with an autism spectrum disorder presents pervasive and bidirectional influences on the entire family system, suggesting a need for family-focused autism spectrum disorder research. While there has been increasing interest in this research area, family-focused autism spectrum disorder research can still be considered relatively recent, and there are limitations to the existing literature. The purpose of this article is to provide theoretical and methodological directions for future family-focused autism spectrum disorder research. In particular, this article proposes Family Systems approaches as a common theoretical framework for future family-focused autism spectrum disorder research by considering theoretical concepts such as Boundaries, Ambiguous Loss, Resilience and Traumatic Growth. We discuss reasons why these concepts are important to researching families living with autism spectrum disorder and provide recommendations for future research. The potential for research grounded in Family Systems approaches to influence clinical support services is also discussed.

  17. A 3-Component Approach Incorporating Focus Groups in Strategic Planning for Sexual Violence Prevention.

    PubMed

    Cruz, Theresa H; Hess, Julia Meredith; Woelk, Leona; Bear, Samantha

    2016-01-01

    Sexual violence is of special concern in New Mexico because of the presence of large priority populations in which its prevalence is high. This article describes a 3-component approach to developing a strategic plan to prevent sexual violence in the state that consisted of an advisory group, subject matter experts, and focus groups from geographically and demographically diverse communities. Both common and community-specific themes emerged from the focus groups and were included in the strategic plan. By incorporating community needs and experiences, this approach fosters increased investment in plan implementation.

  18. A new approach of indirect enzyme-linked immunosorbent assay for determination of D-glutamic acid through in situ conjugation.

    PubMed

    Sakamoto, Seiichi; Nagamitsu, Rika; Matsuura, Yurino; Tsuneura, Yumi; Kurose, Hitoshi; Tanaka, Hiroyuki; Morimoto, Satoshi

    2016-01-01

    We propose a new approach of an indirect enzyme-linked immunosorbent assay (ELISA) for determination of D-glutamic acid (D-Glu) using a monoclonal antibody against D-glutamic acid (D-Glu-MAb), which recognizes D-Glu-glutaraldehyde (GA) molecule but not D-Glu molecule. Human serum albumin (HSA) was coated on an immunoplate and reacted with D-Glu via GA to produce D-Glu-GA-HSA conjugates in situ in the well to be recognized by D-Glu-MAb, which enabled the development of an indirect ELISA for the determination of free D-Glu. In this indirect ELISA, D-Glu can be specifically detected with limit of detection of 7.81 μ g/mL. Since anti-conjugate antibodies are often produced, even though anti-hapten antibodies are desired, this new approach could be very useful as an application of anti-conjugate antibodies to the development of quantitative analysis for detecting hapten.

  19. Concern-Focused Evaluation for Ambiguous and Conflicting Policies: An Approach from the Environmental Field

    ERIC Educational Resources Information Center

    Mermet, Laurent; Bille, Raphael; Leroy, Maya

    2010-01-01

    Environment and sustainable development show how policies are becoming ever more complex and ambiguous. This trend calls for new evaluation approaches. They need to be more clearly focused on specific, explicit concerns. They must be driven by a strategic concept of use to overcome the vulnerability to manipulation of many integrative, essentially…

  20. Family Involvement in the Treatment of Anorexia Nervosa: A Solution-Focused Approach.

    ERIC Educational Resources Information Center

    O'Halloran, M. Sean

    1999-01-01

    Presents example of solution-focused brief therapy with an anorexic client that has implications for treating clients with less severe eating disorders. Approach emphasizes acceptance of client's problem-oriented descriptions, and views client as expert on his/her own life. Process builds on what client would like to see changed. (Author/JDM)

  1. Influence of a Parent-Child Interaction Focused Bookmaking Approach on Maternal Parenting Self-Efficacy

    ERIC Educational Resources Information Center

    Boyce, Lisa K.; Seedall, Ryan B.; Innocenti, Mark S.; Roggman, Lori A.; Cook, Gina A.; Hagman, Amanda M.; Jump Norman, Vonda K.

    2017-01-01

    We examined the effects of our parent-child interaction focused bookmaking intervention with 89 families and their toddlers receiving early intervention services. Participating early intervention providers (N = 24) were assigned to either continue providing services as usual or participate in training to implement the bookmaking approach in their…

  2. Assessing Students' Perceptions of Campus Community: A Focus Group Approach. Professional File. Number 95, Spring 2005

    ERIC Educational Resources Information Center

    Cheng, David X.

    2005-01-01

    This paper offers a focus group approach to the understanding of student perceptions of campus community. Using the Strange and Banning (2001) framework of community, the author argues that students' sense of campus community should be studied as it exists within the institutional environment. The results of the study include: 1) There is a strong…

  3. Indirect inversions

    NASA Astrophysics Data System (ADS)

    Sergienko, Olga

    2013-04-01

    Since Doug MacAyeal's pioneering studies of the ice-stream basal traction optimizations by control methods, inversions for unknown parameters (e.g., basal traction, accumulation patterns, etc) have become a hallmark of the present-day ice-sheet modeling. The common feature of such inversion exercises is a direct relationship between optimized parameters and observations used in the optimization procedure. For instance, in the standard optimization for basal traction by the control method, ice-stream surface velocities constitute the control data. The optimized basal traction parameters explicitly appear in the momentum equations for the ice-stream velocities (compared to the control data). The inversion for basal traction is carried out by minimization of the cost (or objective, misfit) function that includes the momentum equations facilitated by the Lagrange multipliers. Here, we build upon this idea, and demonstrate how to optimize for parameters indirectly related to observed data using a suite of nested constraints (like Russian dolls) with additional sets of Lagrange multipliers in the cost function. This method opens the opportunity to use data from a variety of sources and types (e.g., velocities, radar layers, surface elevation changes, etc.) in the same optimization process.

  4. IR spectral density of weak H-bonds involving indirect damping. I. A new approach using non-Hermitean effective Hamiltonians

    NASA Astrophysics Data System (ADS)

    Belharaya, Khedidja; Blaise, Paul; Henri-Rousseau, Olivier

    2003-08-01

    A new approach of the combined effects of quantum direct and indirect dampings (within the adiabatic approximation) on the infrared lineshapes of the νX-H stretching mode of simple and single weak H-bonds is proposed. The approach is based on our precedent model dealing only with bare weak H-bonds [B. Boulil, O. Henri-Rousseau , P. Blaise Chem. Phys. 126 (1988) 263; B. Boulil, J.-L. Déjardin, N. El-Ghandour, O. Henri-Rousseau, J. Mol. Struct. (Theochem) 314 (1994) 83]. As in this initial model, the indirect relaxation of the H-bond bridge is described by the aid of the driven damped quantum harmonic oscillator model [W. Louisell, L. Walker, Phys. Rev. 137 (1965) 204]. It is shown that the Hamiltonian characterizing the driven damped quantum harmonic oscillator may be obtained in a non-Hermitean reduced form, allowing, contrarily to the initial approach, the possibility of generalizations to more complex situations than those of bare H-bonds.

  5. Semiclassical limit of the focusing NLS: Whitham equations and the Riemann-Hilbert Problem approach

    NASA Astrophysics Data System (ADS)

    Tovbis, Alexander; El, Gennady A.

    2016-10-01

    The main goal of this paper is to put together: a) the Whitham theory applicable to slowly modulated N-phase nonlinear wave solutions to the focusing nonlinear Schrödinger (fNLS) equation, and b) the Riemann-Hilbert Problem approach to particular solutions of the fNLS in the semiclassical (small dispersion) limit that develop slowly modulated N-phase nonlinear wave in the process of evolution. Both approaches have their own merits and limitations. Understanding of the interrelations between them could prove beneficial for a broad range of problems involving the semiclassical fNLS.

  6. A Compassion-Focused Approach to Working With Someone Diagnosed With Schizophrenia.

    PubMed

    Kennedy, Angela; Ellerby, Mark

    2016-02-01

    This case report is a shared, compassion-focused therapy account between a therapist and someone with a 20-year history of schizophrenia. It shows the usefulness of compassion in facilitating the courage to address the worst symptoms of psychosis. It does this by promoting a mindfulness of mind and emotional regulation. This approach helped create an alternative position from which to ground and anchor the self so psychotic fears were less able to dominate.

  7. Indirect role of microRNAs and transcription factors in the regulation of important cancer genes: A network biology approach.

    PubMed

    Ahmadi, M; Jafari, R; Marashi, S A; Farazmand, A

    2015-10-30

    Cancer is one of the leading causes of death worldwide. Although the mechanisms of gene regulation in cancer have been the subject of intense investigation during the last decades, the precise role of regulatory processes in cancer is largely unknown. More specifically, it is not completely understood how microRNAs and transcription factors regulate and influence the cancer-related processes. In the present study, using cancer-specific biological networks we examine the role of microRNAs and transcription factors (TFs) in regulation of important cancer genes. The importance measures which are used in this study consider both network structure information and biological data on miRNA- and TF-based gene regulation. By analyzing cancer-specific PPI, signaling and metabolic networks, it was shown that microRNAs and transcription factors tend to regulate those genes which are in the neighborhood of important components of cancer-specific PPI, signaling, and metabolic networks. The role of microRNAs was found to be particularly important, which confirms our previously-published results on the importance of microRNAs in detecting important network components. Moreover, we highlight that the miRNAs appear to apply their function via regulating the "neighbors" of important cancer genes, which implies their indirect role in cancer, and presumably, in fine-tuning the effect of other cancer-related genes.

  8. A principal stratification approach for evaluating natural direct and indirect effects in the presence of treatment-induced intermediate confounding.

    PubMed

    Taguri, Masataka; Chiba, Yasutaka

    2015-01-15

    Recently, several authors have shown that natural direct and indirect effects (NDEs and NIEs) can be identified under the sequential ignorability assumptions, as long as there is no mediator-outcome confounder that is affected by the treatment. However, if such a confounder exists, NDEs and NIEs will generally not be identified without making additional identifying assumptions. In this article, we propose novel identification assumptions and estimators for evaluating NDEs and NIEs under the usual sequential ignorability assumptions, using the principal stratification framework. It is assumed that the treatment and the mediator are dichotomous. We must impose strong assumptions for identification. However, even if these assumptions were violated, the bias of our estimator would be small under typical conditions, which can be easily evaluated from the observed data. This conjecture is confirmed for binary outcomes by deriving the bounds of the bias terms. In addition, the advantage of our estimator is illustrated through a simulation study. We also propose a method of sensitivity analysis that examines what happens when our assumptions are violated. We apply the proposed method to data from the National Center for Health Statistics.

  9. Direct and indirect indicators to identify potential leakage of contaminants associated with unconventional oil and gas development based on conceptual geochemical and isotopic monitoring approaches

    NASA Astrophysics Data System (ADS)

    Humez, P.; Mayer, B.; Negrel, P. J.; Lions, J.; Lagneau, V.; Kloppmann, W.; Ing, J.; Becker, V.; Nightingale, M.

    2014-12-01

    The extraction of tightly bound natural gas and oil raises environmental concerns regarding shallow drinking water resources. These concerns include impacts of migration of contaminants through induced and natural fractures, drilling imperfections, wastewater discharge and accidental spills. Improved understanding of the fate and transport of contaminants through long-term monitoring, and sharing of data between industry, regulators and researchers will help to effectively manage risks for shallow water resources associated with the unconventional gas and oil industry. Based on the North-American experiences related to unconventional oil and gas resources and monitoring approaches developed in the Carbon Capture and Storage (CCS) context, we suggest conceptual models for monitoring the potential contamination of shallow aquifers overlying production zones. The strength of sensitive geochemical tracers is demonstrated based on conceptual approaches (e.g. diffusion model) and field and tracer studies (e.g. geochemical and isotopic monitoring) with three objectives: 1) characterize subsurface derived contaminants as direct geochemical and isotopic indicators; 2) assess geochemical processes enhanced by the fluid intrusion; 3) understand parameters and processes which could impact or alter the geochemical and isotopic signatures of the contaminants (e.g. microbial oxidation, migration or transport processes etc.) to determine indirect indicators of potential contaminant leakage. This comprehensive geochemical and isotope approach using direct and indirect indicators with the analyses of major and minor ions, trace elements, and δ11B, δ7Li, δ34SSO4, δ18OSO4, 87Sr/86Sr, δ18OH2O, and δ2HH2O values in the CO2FIELDLAB project (Humez et al., 2014) allowed discriminating reactive mechanisms from non-reactive mixing processes associated with gas leakage within a shallow aquifer. These and other results indicate that this conceptual approach is promising for monitoring

  10. A comparison of consumptive-use estimates derived from the simplified surface energy balance approach and indirect reporting methods

    USGS Publications Warehouse

    Maupin, Molly A.; Senay, Gabriel B.; Kenny, Joan F.; Savoca, Mark E.

    2012-01-01

    Recent advances in remote-sensing technology and Simplified Surface Energy Balance (SSEB) methods can provide accurate and repeatable estimates of evapotranspiration (ET) when used with satellite observations of irrigated lands. Estimates of ET are generally considered equivalent to consumptive use (CU) because they represent the part of applied irrigation water that is evaporated, transpired, or otherwise not available for immediate reuse. The U.S. Geological Survey compared ET estimates from SSEB methods to CU data collected for 1995 using indirect methods as part of the National Water Use Information Program (NWUIP). Ten-year (2000-2009) average ET estimates from SSEB methods were derived using Moderate Resolution Imaging Spectroradiometer (MODIS) 1-kilometer satellite land surface temperature and gridded weather datasets from the Global Data Assimilation System (GDAS). County-level CU estimates for 1995 were assembled and referenced to 1-kilometer grid cells to synchronize with the SSEB ET estimates. Both datasets were seasonally and spatially weighted to represent the irrigation season (June-September) and those lands that were identified in the county as irrigated. A strong relation (R2 greater than 0.7) was determined between NWUIP CU and SSEB ET data. Regionally, the relation is stronger in arid western states than in humid eastern states, and positive and negative biases are both present at state-level comparisons. SSEB ET estimates can play a major role in monitoring and updating county-based CU estimates by providing a quick and cost-effective method to detect major year-to-year changes at county levels, as well as providing a means to disaggregate county-based ET estimates to sub-county levels. More research is needed to identify the causes for differences in state-based relations.

  11. Indirect resin composites

    PubMed Central

    Nandini, Suresh

    2010-01-01

    Aesthetic dentistry continues to evolve through innovations in bonding agents, restorative materials, and conservative preparation techniques. The use of direct composite restoration in posterior teeth is limited to relatively small cavities due to polymerization stresses. Indirect composites offer an esthetic alternative to ceramics for posterior teeth. This review article focuses on the material aspect of the newer generation of composites. This review was based on a PubMed database search which we limited to peer-reviewed articles in English that were published between 1990 and 2010 in dental journals. The key words used were ‘indirect resin composites,’ composite inlays,’ and ‘fiber-reinforced composites.’ PMID:21217945

  12. Predicting how individuals approach enrichment: regulatory focus in cotton-top tamarins (Sanguinus oedipus).

    PubMed

    Franks, Becca; Reiss, Diana; Cole, Patricia; Friedrich, Volney; Thompson, Nicole; Higgins, E Tory

    2013-01-01

    Evidence is mounting that personality is associated with health and well-being in humans and other animals. In a step towards increasing our understanding of this link, we applied regulatory focus theory, a motivational perspective from social psychology, to the behavior of zoo-housed cotton top tamarins. We tested whether regulatory focus "personality," that is stable differences in whether an individual is motivated by gains versus safety, would 1) produce individual differences in behavior and 2) predict how individuals interact with enrichment. First, we characterized individuals with respect to several key behaviors: eating in the open, hiding, and time spent near the front of the exhibit. The monkeys were consistent in their behavioral tendencies across the 6-month study, allowing regulatory focus classification. One monkey showed evidence of being a promotion-individual, that is, more motivated by gains than safety. One monkey showed evidence of being a prevention-individual, that is, more motivated by safety than gains. The other monkeys were stable in their behavior and showed evidence of being intermediate-individuals, that is, they favored neither gains nor safety. Using these characterizations, we predicted distinct patterns of individual-object interactions with enrichment. For example, we predicted that a promotion-individual (favoring gains over safety) would approach potential gains faster than a prevention-individual (favoring safety over gains). Counter-intuitively, however, we also predicted that a promotion-individual would approach non-gains slower than a prevention-individual concerned with safety. We found support for our predictions, which suggests that regulatory focus theory could be a useful tool for understanding how and why individuals interact with environmental enrichment.

  13. Cultural dissonance among generations: a solution-focused approach with East Asian elders and their families.

    PubMed

    Lee, Mo Yee; Mjelde-Mossey, LeeAnn

    2004-10-01

    In traditional East Asian cultures, high value is assigned to family harmony and filial piety coupled with the expectation that elders will be honored and obeyed. A lifetime of such expectations shapes how elders perceive their role and status in the family. Problems can arise when younger, less traditional, generations do not share these expectations. This article describes a solution-focused approach that facilitates the family in creating a beneficial harmony in situations of cultural dissonance. Family members are empowered to draw on personal strengths in which multiple worldviews and values of individual members are recognized, incorporated, and negotiated.

  14. Approaching confidentiality at a familial level in genomic medicine: a focus group study with healthcare professionals

    PubMed Central

    Dheensa, Sandi; Fenwick, Angela; Lucassen, Anneke

    2017-01-01

    Objectives Clinical genetics guidelines from 2011 conceptualise genetic information as confidential to families, not individuals. The normative consequence of this is that the family's interest is the primary consideration and genetic information is shared unless there are good reasons not to do so. We investigated healthcare professionals' (HCPs') views about, and reasoning around, individual and familial approaches to confidentiality and how such views influenced their practice. Method 16 focus groups with 80 HCPs working in/with clinical genetics services were analysed, drawing on grounded theory. Results Participants raised seven problems with, and arguments against, going beyond the individual approach to confidentiality. These problems fell into two overlapping categories: ‘relationships’ and ‘structures’. Most participants had never considered ways to—or thought it was impossible to—treat familial genetic information and personal information differently. They worried that putting the familial approach into practice could disrupt family dynamics and erode patient trust in the health service. They also thought they had insufficient resources to share information and feared that sharing might change the standard of care and make them more vulnerable to liability. Conclusions A familial approach to confidentiality has not been accepted or adopted as a standard, but wider research suggests that some of the problems HCPs perceived are surmountable and sharing in the interest of the family can be achieved. However, further research is needed to explore how personal and familial genetic information can be separated in practice. Our findings are relevant to HCPs across health services who are starting to use genome tests as part of their routine investigations. PMID:28159847

  15. Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction

    PubMed Central

    Saunders, Benjamin T.; Richard, Jocelyn M.; Janak, Patricia H.

    2015-01-01

    Tying complex psychological processes to precisely defined neural circuits is a major goal of systems and behavioural neuroscience. This is critical for understanding adaptive behaviour, and also how neural systems are altered in states of psychopathology, such as addiction. Efforts to relate psychological processes relevant to addiction to activity within defined neural circuits have been complicated by neural heterogeneity. Recent advances in technology allow for manipulation and mapping of genetically and anatomically defined neurons, which when used in concert with sophisticated behavioural models, have the potential to provide great insight into neural circuit bases of behaviour. Here we discuss contemporary approaches for understanding reward and addiction, with a focus on midbrain dopamine and cortico-striato-pallidal circuits. PMID:26240425

  16. The feminist/emotionally focused therapy practice model: an integrated approach for couple therapy.

    PubMed

    Vatcher, C A; Bogo, M

    2001-01-01

    Emotionally focused therapy (EFT) is a well-developed, empirically tested practice model for couple therapy that integrates systems, experiential, and attachment theories. Feminist family therapy theory has provided a critique of biased assumptions about gender at play in traditional family therapy practice and the historical absence of discussions of power in family therapy theory. This article presents an integrated feminist/EFT practice model for use in couple therapy, using a case from practice to illustrate key concepts. Broadly, the integrated model addresses gender roles and individual emotional experience using a systemic framework for understanding couple interaction. The model provides practitioners with a sophisticated, comprehensive, and relevant practice approach for working with the issues and challenges emerging for contemporary heterosexual couples.

  17. Applying a solution-focused approach to support a worker who is under stress.

    PubMed

    Mishima, Norio; Kubota, Shinya; Nagata, Shoji

    2005-06-01

    The solution-focused approach (SFA) developed by Insoo Kim Berg and Steve de Shazer at the Brief Family Therapy Center, Milwaukee, USA is classified as brief psychotherapy. We believe that SFA can give an occupational healthcare staff useful tools that will positively influence their relationships with workers, because it focuses on workers' strengths rather than their weaknesses when the staff interviews them using SFA. In this report, we explain the case of a worker who was under stress and was interviewed using SFA. Although the worker came to the interview because of his physical symptoms, he disclosed that he was under considerable stress at work and that his main concern was his relationship with his superior. One of the authors interviewed him using SFA. In the interview the worker discovered his own resources and strengths, and finally defined his goal. In the end, he discovered solutions by himself, and has been doing well in follow-up. We describe this process in detail, and discuss potential applications of SFA in occupational medicine.

  18. Usefulness of a trauma-focused treatment approach for travel phobia.

    PubMed

    de Jongh, Ad; Holmshaw, Manda; Carswell, Wilson; van Wijk, Arjen

    2011-01-01

    Despite its prevalence and potential impact on functioning, there are surprisingly little data regarding the treatment responsiveness of travel phobia. The purpose of this non-randomized study was to evaluate the usefulness of a trauma-focused treatment approach for travel phobia, or milder travel anxiety arising as a result of a road traffic accident. Trauma-focused Cognitive Behavioural Therapy (TF-CBT), and Eye Movement Desensitization and Reprocessing were used to treat a sample of 184 patients, who were referred to a psychological rehabilitation provider. Patients in both treatment groups were encouraged to encounter their feared objects and situations between sessions. Specific (i.e., travel) phobia was diagnosed in 57% of cases. Patients in both treatment conditions showed equally large, and clinically significant, decreases in symptoms as indexed by three validated measures (Impact of Event Scale, Hospital Anxiety and Depression Scale, and General Health Questionnaire), therapist ratings of treatment outcome, and a return to driving or travelling by car or motorbike. These improvements were obtained within an average course of 7.3 sessions of 1 hour each. Patients with travel phobia responded with a greater reduction of anxiety and post-traumatic stress disorder symptoms than those with milder travel anxiety. Passengers reported higher levels of trauma symptoms than drivers, but no difference in effectiveness of treatment was found between these groups. The results suggest that trauma-focused psychological interventions can be a treatment alternative for patients with travel anxiety. Given the seriousness of the clinical problems related to road traffic accidents more rigorous outcome research is warranted and needed.

  19. The Indirect Approach to Counterterrorism

    DTIC Science & Technology

    2008-01-01

    Jolmson, R. W. "Zimbabwe: The Case for Intervention." Current History no. 700 (May 2007): 233-235. KnobleI’, Stacey, Joshua Lederberg , Leslie A. Pray, and...Knobler, Joshua Leperberg, Leslie A. Pray, and Institute of Medicine . Forum on Emerging Infections. Considerations for Viral Disease Eradication

  20. Prediction of community prevalence of human onchocerciasis in the Amazonian onchocerciasis focus: Bayesian approach.

    PubMed Central

    Carabin, Hélène; Escalona, Marisela; Marshall, Clare; Vivas-Martínez, Sarai; Botto, Carlos; Joseph, Lawrence; Basáñez, María-Gloria

    2003-01-01

    OBJECTIVE: To develop a Bayesian hierarchical model for human onchocerciasis with which to explore the factors that influence prevalence of microfilariae in the Amazonian focus of onchocerciasis and predict the probability of any community being at least mesoendemic (>20% prevalence of microfilariae), and thus in need of priority ivermectin treatment. METHODS: Models were developed with data from 732 individuals aged > or =15 years who lived in 29 Yanomami communities along four rivers of the south Venezuelan Orinoco basin. The models' abilities to predict prevalences of microfilariae in communities were compared. The deviance information criterion, Bayesian P-values, and residual values were used to select the best model with an approximate cross-validation procedure. FINDINGS: A three-level model that acknowledged clustering of infection within communities performed best, with host age and sex included at the individual level, a river-dependent altitude effect at the community level, and additional clustering of communities along rivers. This model correctly classified 25/29 (86%) villages with respect to their need for priority ivermectin treatment. CONCLUSION: Bayesian methods are a flexible and useful approach for public health research and control planning. Our model acknowledges the clustering of infection within communities, allows investigation of links between individual- or community-specific characteristics and infection, incorporates additional uncertainty due to missing covariate data, and informs policy decisions by predicting the probability that a new community is at least mesoendemic. PMID:12973640

  1. Bioechnology of indirect liquefaction

    SciTech Connect

    Datta, R.; Jain, M.K.; Worden, R.M.; Grethlein, A.J.; Soni, B.; Zeikus, J.G.; Grethlein, H.

    1990-05-07

    The project on biotechnology of indirect liquefaction was focused on conversion of coal derived synthesis gas to liquid fuels using a two-stage, acidogenic and solventogenic, anaerobic bioconversion process. The acidogenic fermentation used a novel and versatile organism, Butyribacterium methylotrophicum, which was fully capable of using CO as the sole carbon and energy source for organic acid production. In extended batch CO fermentations the organism was induced to produce butyrate at the expense of acetate at low pH values. Long-term, steady-state operation was achieved during continuous CO fermentations with this organism, and at low pH values (a pH of 6.0 or less) minor amounts of butanol and ethanol were produced. During continuous, steady-state fermentations of CO with cell recycle, concentrations of mixed acids and alcohols were achieved (approximately 12 g/l and 2 g/l, respectively) which are high enough for efficient conversion in stage two of the indirect liquefaction process. The metabolic pathway to produce 4-carbon alcohols from CO was a novel discovery and is believed to be unique to our CO strain of B. methylotrophicum. In the solventogenic phase, the parent strain ATCC 4259 of Clostridium acetobutylicum was mutagenized using nitrosoguanidine and ethyl methane sulfonate. The E-604 mutant strain of Clostridium acetobutylicum showed improved characteristics as compared to parent strain ATCC 4259 in batch fermentation of carbohydrates.

  2. Tensions between Knowledge Transmission and Student-Focused Teaching Approaches to Assessment Purposes: Helping Students Improve through Transmission

    ERIC Educational Resources Information Center

    Chen, Junjun; Brown, Gavin T. L.

    2016-01-01

    This study surveyed 1064 Chinese school teachers' approaches to teaching and conceptions of assessment, and examined their inter-relationship using confirmatory factor analysis and structural equation modeling. Three approaches to teaching (i.e. Knowledge Transmission, Student-Focused, and Examination Preparation) and six conceptions of assessment…

  3. In the Case of a Depressed Woman: Solution-Focused or Narrative Therapy Approaches?

    ERIC Educational Resources Information Center

    Andrews, Jennifer; Clark, David

    1996-01-01

    Using a case example, provides an overview of postmodern therapies in family counseling. Focuses on solution-focused therapy and narrative therapy; presents an example of a solution-focused interview and a narrative interview. Emphasizes that different views lead to different therapeutic goals and practices. (RJM)

  4. Ethnographic Approach to Second Life in Education: A Focus on Technological Difficulties

    ERIC Educational Resources Information Center

    Sponsiello, Marta; Gallego-Arrufat, María-Jesús

    2016-01-01

    This paper moves from the data collected during an ethnographic research conducted in Second Life, which focuses on the observation of different technological difficulties in educational experiences. The main research interests focused on the social dynamics of educational experiences in Second Life and the opportunity to develop a proper research…

  5. Family-Focused Autism Spectrum Disorder Research: A Review of the Utility of Family Systems Approaches

    ERIC Educational Resources Information Center

    Cridland, Elizabeth K.; Jones, Sandra C.; Magee, Christopher A.; Caputi, Peter

    2014-01-01

    A family member with an autism spectrum disorder presents pervasive and bidirectional influences on the entire family system, suggesting a need for family-focused autism spectrum disorder research. While there has been increasing interest in this research area, family-focused autism spectrum disorder research can still be considered relatively…

  6. Approaching Adult Education Literature Using the Donlevy Template of Perspectives: A Focus on the Sociological Perspective.

    ERIC Educational Resources Information Center

    Donlevy, James G.; Donlevy, Tia Rice

    1999-01-01

    Discusses the field of adult education, focusing on writings authored from a sociological perspective. Both descriptive and communitarian in focus, this perspective emphasizes the full social world of adults and works to develop morals, values, attitudes, and practices that will preserve and sustain a common social fabric. (Author/LRW)

  7. A Solution-Focused Approach to Mental Health Intervention in School Settings.

    ERIC Educational Resources Information Center

    Gingerich, Wallace J.; Wabeke, Todd

    2001-01-01

    Describes the use of solution-focused brief therapy (SFBT) for working with children who present with mental health problems in the school setting. SFBT eschews a pathology-based model of mental health, focusing instead on the client's strengths and desire to change. Describes the techniques and application of SFBT and discusses the prevalence of…

  8. The Future of Indirect Evidence

    PubMed Central

    Efron, Bradley

    2009-01-01

    Familiar statistical tests and estimates are obtained by the direct observation of cases of interest: a clinical trial of a new drug, for instance, will compare the drug’s effects on a relevant set of patients and controls. Sometimes, though, indirect evidence may be temptingly available, perhaps the results of previous trials on closely related drugs. Very roughly speaking, the difference between direct and indirect statistical evidence marks the boundary between frequentist and Bayesian thinking. Twentieth-century statistical practice focused heavily on direct evidence, on the grounds of superior objectivity. Now, however, new scientific devices such as microarrays routinely produce enormous data sets involving thousands of related situations, where indirect evidence seems too important to ignore. Empirical Bayes methodology offers an attractive direct/indirect compromise. There is already some evidence of a shift toward a less rigid standard of statistical objectivity that allows better use of indirect evidence. This article is basically the text of a recent talk featuring some examples from current practice, with a little bit of futuristic speculation. PMID:21243111

  9. Volatile Organic Compounds source contributions in Paris: Measurement and modeling approaches. Focus on the traffic source

    NASA Astrophysics Data System (ADS)

    Gros, Valerie; Petetin, Hervé; Sarda-Estève, Roland; Kalogridis, Cerise; Baudic, Alexia; Bonnaire, Nicolas; Bonsang, Bernard; Xueref-Rémy, Irène; Ammoura, Lamia; Le Priol, Tiphaine; François Petit, Jean; Sanchez, Olivier; Rosso, Amandine; Perrussel, Olivier; Petit, Jean-Eudes; Sciare, Jean

    2013-04-01

    Paris is one of the few European megacities and with 11 Million inhabitants, almost 1/5 French population lives in Paris and its region. The EU-MEGAPOLI project allowed a detailed characterization of gaseous and particulate pollution in Paris in summer (July 2009) and winter (Jan-Feb 2010). Studies about VOCs source contributions performed for these periods have suggested the importance of traffic emissions, in contradiction with the local emission inventory, for which solvent source is the dominant VOC source in Paris. In order to examine the representativity of such conclusions, one-year (March 2010- March 2011) of continuous measurements of VOCs have been performed at the same urban site in Paris (as part of a French program PRIMEQUAL-FRANCIPOL). In addition, VOCs measurements (along with other gaseous and aerosol compounds) have been performed in a tunnel in order to better characterize the traffic source (October 2012, PRIMEQUAL -PREQUALIF project). Preliminary results will be presented here from this unique dataset, with a focus made on oxygenated compounds (methanol, acetaldehyde, acetone) and aromatic compounds (benzene, toluene, xylens...). We will show that the daily variability of oxygenated compounds is mainly linked to the local traffic source, as suggested by their co-variation with other compounds related to traffic emissions (CO, xylens...). In addition to this local source, we will show that oxygenated compounds baseline concentration levels are significantly enhanced during specific events (of a few day duration) characterized by continental air masses. Surprisingly other long-lived compounds (CO) appear to be much less affected by these events, providing evidences that the nature of these continental sources is not yet well established. Results from VOCs source contributions identification, quantification and geographical origin (Positive Matrix Factorization and Potential Source Contribution Function approaches) will be presented as well as

  10. Indirect pulp therapy and stepwise excavation.

    PubMed

    Bjørndal, Lars

    2008-01-01

    Various treatment concepts have been suggested to solve the deep carious lesion dilemma. Recent systematic reviews are presented. Their conclusions are based on very few studies, and the main message is that optimal randomized clinical studies are lacking. Observational studies on indirect pulp treatment and stepwise excavation demonstrate that these treatments avoid pulp exposures, but it cannot be said which approach is best. A less invasive modified stepwise excavation approach is described, focusing on changing on active lesion into on arrested lesion even without performing an excavation close to the pulp. In Denmark and Sweden a randomized clinical multi-center trial is currently taking place, the Caries and Pulp (CAP) trial. This trial is investigating the effects of stepwise excavation over 2 visits versus 1 complete excavation of deep caries in permanent teeth. Guidelines for treatment are presented.

  11. Indirect pulp therapy and stepwise excavation.

    PubMed

    Bjørndal, Lars

    2008-07-01

    Various treatment concepts have been suggested to solve the deep carious lesion dilemma. Recent systematic reviews are presented. Their conclusions are based on very few studies, and the main message is that optimal randomized clinical studies are lacking. Observational studies on indirect pulp treatment and stepwise excavation demonstrate that these treatments avoid pulp exposures, but it cannot be said which approach is best. A less invasive modified stepwise excavation approach is described, focusing on changing an active lesion into an arrested lesion even without performing an excavation close to the pulp. In Denmark and Sweden a randomized clinical multi-center trial is currently taking place, the Caries and Pulp (CAP) trial. This trial is investigating the effects of stepwise excavation over 2 visits versus 1 complete excavation of deep caries in permanent teeth. Guidelines for treatment are presented.

  12. The impact of culture and employee-focused criteria on productivity: A structural equation modelling approach

    NASA Astrophysics Data System (ADS)

    Ab Hamid, Mohd Rashid; Mustafa, Zainol; Mohd Suradi, Nur Riza; Idris, Fazli; Abdullah, Mokhtar

    2013-04-01

    Culture and employee-focused criteria are important factors for the success of any organization. These factors have to be aligned with the productivity initiatives in the organization in order to gear ahead for excellence. Therefore, this article investigated the impact of culture and employee-focused criteria on productivity in Higher Education Institutions (HEIs) in Malaysia using intangible indicators through core values. The hypothesized relationship was tested using Structural Equation Modeling (SEM) with the PLS estimation technique. 429 questionnaires were returned from the target population. The results of the modelling revealed that the PLS estimation confirmed all the hypotheses tested as in the hypothesized model. The results generally support significant relationships between culture values, employee-focused values and productivity-focused values. The study also confirmed the mediating role of employee-focused values for the relationship between culture values and productivity-focused values. In conclusion, the empirically validated results supported the adequacy of the hypothezised model of the impact of culture and employee-focused criteria on productivity in HEI through value-based indicators.

  13. Indirect Lightning Safety Assessment Methodology

    SciTech Connect

    Ong, M M; Perkins, M P; Brown, C G; Crull, E W; Streit, R D

    2009-04-24

    Lightning is a safety hazard for high-explosives (HE) and their detonators. In the However, the current flowing from the strike point through the rebar of the building The methodology for estimating the risk from indirect lighting effects will be presented. It has two parts: a method to determine the likelihood of a detonation given a lightning strike, and an approach for estimating the likelihood of a strike. The results of these two parts produce an overall probability of a detonation. The probability calculations are complex for five reasons: (1) lightning strikes are stochastic and relatively rare, (2) the quality of the Faraday cage varies from one facility to the next, (3) RF coupling is inherently a complex subject, (4) performance data for abnormally stressed detonators is scarce, and (5) the arc plasma physics is not well understood. Therefore, a rigorous mathematical analysis would be too complex. Instead, our methodology takes a more practical approach combining rigorous mathematical calculations where possible with empirical data when necessary. Where there is uncertainty, we compensate with conservative approximations. The goal is to determine a conservative estimate of the odds of a detonation. In Section 2, the methodology will be explained. This report will discuss topics at a high-level. The reasons for selecting an approach will be justified. For those interested in technical details, references will be provided. In Section 3, a simple hypothetical example will be given to reinforce the concepts. While the methodology will touch on all the items shown in Figure 1, the focus of this report is the indirect effect, i.e., determining the odds of a detonation from given EM fields. Professor Martin Uman from the University of Florida has been characterizing and defining extreme lightning strikes. Using Professor Uman's research, Dr. Kimball Merewether at Sandia National Laboratory in Albuquerque calculated the EM fields inside a Faraday-cage type

  14. A Focus on Purpose: Using a Genre Approach in an EFL Writing Class

    ERIC Educational Resources Information Center

    Myskow, Gordon; Gordon, Kana

    2010-01-01

    This article shows how a genre approach has been used in an EFL high school writing course to teach the university application letter genre to students preparing for post-secondary studies. The authors discuss specific classroom materials to illustrate how a genre-based approach can be employed, not simply to teach static textual patterns but to…

  15. Machine vision approach for improving accuracy of focus-based depth measurements

    NASA Astrophysics Data System (ADS)

    Bryll, Robert

    2008-02-01

    Focus-based depth (Z) measurements are used extensively in industrial metrology and microscopy. Typically, a peak in the focus figure-of-merit of a region is found while moving the lens towards or away from the surface, allowing local recovery of depth. These focus-based measurements are susceptible to errors caused by: (1) Optical aberrations and characteristics of the lens (astigmatism, field curvature); (2) Optical and image sensor misalignments; (3) Image sensor shape errors. Depth measurements of the same artifact can therefore significantly vary depending on the prevailing orientation of the surface texture (due to lens astigmatism) or on the specific position in the field of view. We present a vision-based algorithm to reduce errors in focus-based depth measurements. The algorithm consists of two steps: 1. Offline calibration: We generate a calibration table for the optical system, consisting of a set of Z calibration curves for different locations in the field of view. 2. Run-time correction: During measurement, we determine the Z correction to the focus position using the stored Z calibration curves and a measurement of the local orientation of the surface texture. In our tests, the correction algorithm reduced the depth measurement errors by a factor of 2, on average, for a wide range of surfaces and conditions.

  16. Re-engineering pharmaceutical care: towards a patient-focused care approach.

    PubMed

    al-Shaqha, W M; Zairi, M

    2000-01-01

    As healthcare reform takes shape, many challenges face hospital pharmacists. An opportunity exists to combine the principles of patient-focused care and pharmaceutical care to redesign the role of pharmacy. To achieve this objective, pharmacy departments should adopt business concepts such as process re-engineering. Process re-engineering is a change management tool which aims to produce dramatic improvement in performance measures by re-designing the process. The goal of restructuring is to increase the amount of time pharmacists spend providing pharmaceutical care to patients. The pharmaceutical care concept is a method of delivering pharmaceutical care services that match individual patient needs with the services provided. This article describes many hospital pharmacy department transitions to a patient focused care environment by adopting the patient focused care concept and the process re-engineering to improve the quality of patient care through systems improvement.

  17. Focus on the Customer: A New Approach to State-Level Accountability Reporting and Processes for Higher Education.

    ERIC Educational Resources Information Center

    Ruppert, Sandra S.

    This paper outlines the dimensions of a customer-focused system of accountability and describes approaches taken at the state level to respond to the information needs of a broader client base for higher education. Section 1 traces current trends in the development and implementation of state-level accountability policy for higher education. It…

  18. An Alternative Evaluation Approach for the Problem-Solving Training Program: A Utilization-Focused Evaluation Process.

    ERIC Educational Resources Information Center

    Patton, Michael Quinn

    1984-01-01

    A utilization-focused approach in evaluating a problem-solving skills training program (see TM 510 179) would have placed more emphasis on identifying evaluation users, their information needs, and likely use of findings. Other methods options are also discussed, along with how to prepare decision makers for utilization. (Author/BW)

  19. FDTD approach to optical forces of tightly focused vector beams on metal particles.

    PubMed

    Qin, Jian-Qi; Wang, Xi-Lin; Jia, Ding; Chen, Jing; Fan, Ya-Xian; Ding, Jianping; Wang, Hui-Tian

    2009-05-11

    We propose an improved FDTD method to calculate the optical forces of tightly focused beams on microscopic metal particles. Comparison study on different kinds of tightly focused beams indicates that trapping efficiency can be altered by adjusting the polarization of the incident field. The results also show the size-dependence of trapping forces exerted on metal particles. Transverse tapping forces produced by different illumination wavelengths are also evaluated. The numeric simulation demonstrates the possibility of trapping moderate-sized metal particles whose radii are comparable to wavelength.

  20. Indirect techniques in nuclear astrophysics: a review.

    PubMed

    Tribble, R E; Bertulani, C A; Cognata, M La; Mukhamedzhanov, A M; Spitaleri, C

    2014-10-01

    In this review, we discuss the present status of three indirect techniques that are used to determine reaction rates for stellar burning processes, asymptotic normalization coefficients, the Trojan Horse method and Coulomb dissociation. A comprehensive review of the theory behind each of these techniques is presented. This is followed by an overview of the experiments that have been carried out using these indirect approaches.

  1. Benefits, Barriers, and Cues to Action of Yoga Practice: A Focus Group Approach

    ERIC Educational Resources Information Center

    Atkinson, Nancy L.; Permuth-Levine, Rachel

    2009-01-01

    Objectives: To explore perceived benefits, barriers, and cues to action of yoga practice among adults. Methods: Focus groups were conducted with persons who had never practiced yoga, practitioners of one year or less, and practitioners for more than one year. The Health Belief Model was the theoretical foundation of inquiry. Results: All…

  2. Focus on the Hands: A Beginning Approach to Teaching Typing to Visually Impaired, Multiply Handicapped Students.

    ERIC Educational Resources Information Center

    Dibble, Frances J. Bauer

    1984-01-01

    The author describes the value to visually impaired and multiply handicapped students of a good typewriting curriculum. She discusses hand and finger exercises and notes benefits to students from focusing on the hands as well as on the rudiments and total communicative value of typing. (CL)

  3. Solution-Focused Brief Therapy: An Interventional Approach to Improving Negative Student Behaviors

    ERIC Educational Resources Information Center

    Vallaire-Thomas, Lola; Hicks, Jamilah; Growe, Roslin

    2011-01-01

    Inappropriate behaviors of elementary and middle school students are many times extremely difficult to change. These behaviors tend to be supported by reinforcement within the environment. When manifested in the classroom, these undesirable actions become the focus of negativity which translates into disciplinary problems and ultimately discipline…

  4. Learning Cycles and Focus Groups: A Complementary Approach to the A3 Thinking Methodology

    ERIC Educational Resources Information Center

    Tortorella, Guilherme Luz; Viana, Samanta; Fettermann, Diego

    2015-01-01

    Purpose: This study aims to propose a complementary method to the A3 information collection, data analysis and capturing and sharing knowledge to facilitate problem solving in a general framework. The incorporation of this method minimizes the difficulties identified in the literature focused on continuous improvement of processes. The method…

  5. A New Approach: The Cairo Conference. Focus: Education, Population, and Development.

    ERIC Educational Resources Information Center

    Jolis, Cilla Ungerth, Ed.

    1994-01-01

    This bulletin provides news on the follow-up to the World Conference on Education for All (Jomtien, Thailand, 1990) at which 155 countries pledged to provide education for all children and adults and massively reduce illiteracy before the year 2000. This bulletin focuses on the September 1994 Cairo (Egypt) Population Conference and the issues of…

  6. Solution-Focused Therapy as a Culturally Acknowledging Approach with American Indians

    ERIC Educational Resources Information Center

    Meyer, Dixie D.; Cottone, R. Rocco

    2013-01-01

    Limited literature is available applying specific theoretical orientations with American Indians. Solution-focused therapy may be appropriate, given the client-identified solutions, the egalitarian counselor/client relationship, the use of relationships, and the view that change is inevitable. However, adaption of scaling questions and the miracle…

  7. Evaluating the Impact of Professional Development: The Need for a Student-Focused Approach

    ERIC Educational Resources Information Center

    Earley, Peter; Porritt, Vivienne

    2014-01-01

    This article argues that evaluation of professional development (PD) requires a focus on student learning and an evidential baseline to enable practitioners and school leaders to determine the impact of the PD in which they are engaged. Several models of evaluating PD are briefly considered and it is suggested that most of these enable programme…

  8. Pulling on the Heart Strings: An Emotionally Focused Approach to Family Life Cycle Transitions.

    ERIC Educational Resources Information Center

    Dankoski, Mary E.

    2001-01-01

    Open communication and processing of primary attachment emotions are crucial when family systems change. Emotionally focused therapy (EFT) can be helpful by encouraging family members to express primary emotions. Expression then fosters renegotiation of bonds and clarification of attachment concerns. Case examples illustrate how EFT can be applied…

  9. A Program Guide for Counseling and Psychological Services in Catholic Schools: A Solution-Focused Approach

    ERIC Educational Resources Information Center

    Gonzalez, Andrea Kelly

    2013-01-01

    Historically, the Catholic school system has not regarded counseling services or comprehensive counseling programs as a required element in education. Only in recent years have most dioceses decreed that Catholic schools must implement a developmental counseling and guidance program. The focus of most research studies and the advancement of the…

  10. Virtual Focus Groups in Extension: A Useful Approach to Audience Analysis

    ERIC Educational Resources Information Center

    Warner, Laura A.

    2014-01-01

    As change agents, Extension educators may begin their program planning by identifying the audience's perceived barriers and benefits to adopting some behavior that will benefit the community. Extension professionals and researchers have used in-person focus groups to understand an audience, and they can also administer them as…

  11. Analytical approach to chromatic correction in the final focus system of circular colliders

    NASA Astrophysics Data System (ADS)

    Cai, Yunhai

    2016-11-01

    A conventional final focus system in particle accelerators is systematically analyzed. We find simple relations between the parameters of two focus modules in the final telescope. Using the relations, we derive the chromatic Courant-Snyder parameters for the telescope. The parameters are scaled approximately according to (L*/βy*)δ , where L* is the distance from the interaction point to the first quadrupole, βy* the vertical beta function at the interaction point, and δ the relative momentum deviation. Most importantly, we show how to compensate its chromaticity order by order in δ by a traditional correction module flanked by an asymmetric pair of harmonic multipoles. The method enables a circular Higgs collider with 2% momentum aperture and illuminates a path forward to 4% in the future.

  12. Time to reconsider our approach to echogenic intracardiac focus and choroid plexus cysts.

    PubMed

    Bethune, Michael

    2008-04-01

    Ultrasound soft markers are commonly reported at mid-trimester ultrasounds. Soft markers frequently arouse anxiety in the patient, her family, and the referring clinician. Recent publications have raised concerns that this anxiety may be unfounded. The significance of an echogenic intracardiac focus or choroid plexus cyst in particular is no longer certain. It may be time to discard these two markers; especially if they are reported in isolation and in a patient who is otherwise at low risk for aneuploidy.

  13. The mixed waste focus area mercury working group: an integrated approach for mercury treatment and disposal

    SciTech Connect

    Conley, T.B.; Morris, M.I.; Holmes-Burns, H.; Petersell, J.; Schwendiman, L.

    1997-02-01

    In May 1996, the U.S. Department of Energy (DOE) Mixed Waste Focus Area (MWFA) initiated the Mercury Work Group (HgWG), which was established to address and resolve the issues associated with mercury- contaminated mixed wastes. Three of the first four technology deficiencies identified during the MWFA technical baseline development process were related to mercury amalgamation, stabilization, and separation/removal. The HgWG will assist the MWFA in soliciting, identifying, initiating, and managing all the efforts required to address these deficiencies. The focus of the HgWG is to better establish the mercury-related treatment needs at the DOE sites, refine the MWFA technical baseline as it relates to mercury treatment, and make recommendations to the MWFA on how to most effectively address these needs. The team will initially focus on the sites with the most mercury-contaminated mixed wastes, whose representatives comprise the HgWG. However, the group will also work with the sites with less inventory to maximize the effectiveness of these efforts in addressing the mercury- related needs throughout the entire complex.

  14. The FLOWLENS: a focus-and-context visualization approach for exploration of blood flow in cerebral aneurysms.

    PubMed

    Gasteiger, Rocco; Neugebauer, Mathias; Beuing, Oliver; Preim, Bernhard

    2011-12-01

    Blood flow and derived data are essential to investigate the initiation and progression of cerebral aneurysms as well as their risk of rupture. An effective visual exploration of several hemodynamic attributes like the wall shear stress (WSS) and the inflow jet is necessary to understand the hemodynamics. Moreover, the correlation between focus-and-context attributes is of particular interest. An expressive visualization of these attributes and anatomic information requires appropriate visualization techniques to minimize visual clutter and occlusions. We present the FLOWLENS as a focus-and-context approach that addresses these requirements. We group relevant hemodynamic attributes to pairs of focus-and-context attributes and assign them to different anatomic scopes. For each scope, we propose several FLOWLENS visualization templates to provide a flexible visual filtering of the involved hemodynamic pairs. A template consists of the visualization of the focus attribute and the additional depiction of the context attribute inside the lens. Furthermore, the FLOWLENS supports local probing and the exploration of attribute changes over time. The FLOWLENS minimizes visual cluttering, occlusions, and provides a flexible exploration of a region of interest. We have applied our approach to seven representative datasets, including steady and unsteady flow data from CFD simulations and 4D PC-MRI measurements. Informal user interviews with three domain experts confirm the usefulness of our approach.

  15. Dual-core mass-balance approach for evaluating mercury and 210Pb atmospheric fallout and focusing to lakes.

    PubMed

    Van Metre, Peter C; Fuller, Christopher C

    2009-01-01

    Determining atmospheric deposition rates of mercury and other contaminants using lake sediment cores requires a quantitative understanding of sediment focusing. Here we present a novel approach that solves mass-balance equations fortwo cores algebraicallyto estimate contaminant contributions to sediment from direct atmospheric fallout and from watershed and in-lake focusing. The model is applied to excess 210Pb and Hg in coresfrom Hobbs Lake, a high-altitude lake in Wyoming. Model results for excess 210Pb are consistent with estimates of fallout and focusing factors computed using excess 210Pb burdens in lake cores and soil cores from the watershed and model results for Hg fallout are consistent with fallout estimated using the soil-core-based 210Pb focusing factors. The lake cores indicate small increases in mercury deposition beginning in the late 1800s and large increases after 1940, with the maximum at the tops of the cores of 16-20 microg/m2 x year. These results suggest that global Hg emissions and possibly regional emissions in the western United States are affecting the north-central Rocky Mountains. Hg fallout estimates are generally consistent with fallout reported from an ice core from the nearby Upper Fremont Glacier, but with several notable differences. The model might not work for lakes with complex geometries and multiple sediment inputs, but for lakes with simple geometries, like Hobbs, it can provide a quantitative approach for evaluating sediment focusing and estimating contaminant fallout.

  16. Dual-core mass-balance approach for evaluating mercury and210Pb atmospheric fallout and focusing to lakes

    USGS Publications Warehouse

    Van Metre, P.C.; Fuller, C.C.

    2009-01-01

    Determining atmospheric deposition rates of mercury and other contaminants using lake sediment cores requires a quantitative understanding of sediment focusing. Here we present a novel approach that solves mass-balance equations for two cores algebraically to estimate contaminant contributions to sediment from direct atmospheric fallout and from watershed and in-lake focusing. The model is applied to excess 210Pb and Hg in cores from Hobbs Lake, a high-altitude lake in Wyoming. Model results for excess 210Pb are consistent with estimates of fallout and focusing factors computed using excess 210Pb burdens in lake cores and soil cores from the watershed and model results for Hg fallout are consistent with fallout estimated using the soil-core-based 210Pb focusing factors. The lake cores indicate small increases in mercury deposition beginning in the late 1800s and large increases after 1940, with the maximum at the tops of the cores of 16-20 ??g/m 2year. These results suggest that global Hg emissions and possibly regional emissions in the western United States are affecting the north-central Rocky Mountains. Hg fallout estimates are generally consistent with fallout reported from an ice core from the nearby Upper Fremont Glacier, but with several notable differences. The model might not work for lakes with complex geometries and multiple sediment inputs, but for lakes with simple geometries, like Hobbs, it can provide a quantitative approach for evaluating sediment focusing and estimating contaminant fallout.

  17. A Dual Approach to Fostering Under-Prepared Student Success: Focusing on Doing and Becoming

    ERIC Educational Resources Information Center

    Shaffer, Suzanne C.; Eshbach, Barbara E.; Santiago-Blay, Jorge A.

    2015-01-01

    A paired course model for under-prepared college students incorporates a dual instructional approach, academic skill building and lifelong learning development, to help students do more academically and become stronger lifelong learners. In a reading support course, students improved their reading skills and applied them directly to the paired…

  18. Evaluating impacts using a BACI design, ratios, and a Bayesian approach with a focus on restoration.

    PubMed

    Conner, Mary M; Saunders, W Carl; Bouwes, Nicolaas; Jordan, Chris

    2015-10-01

    Before-after-control-impact (BACI) designs are an effective method to evaluate natural and human-induced perturbations on ecological variables when treatment sites cannot be randomly chosen. While effect sizes of interest can be tested with frequentist methods, using Bayesian Markov chain Monte Carlo (MCMC) sampling methods, probabilities of effect sizes, such as a ≥20 % increase in density after restoration, can be directly estimated. Although BACI and Bayesian methods are used widely for assessing natural and human-induced impacts for field experiments, the application of hierarchal Bayesian modeling with MCMC sampling to BACI designs is less common. Here, we combine these approaches and extend the typical presentation of results with an easy to interpret ratio, which provides an answer to the main study question-"How much impact did a management action or natural perturbation have?" As an example of this approach, we evaluate the impact of a restoration project, which implemented beaver dam analogs, on survival and density of juvenile steelhead. Results indicated the probabilities of a ≥30 % increase were high for survival and density after the dams were installed, 0.88 and 0.99, respectively, while probabilities for a higher increase of ≥50 % were variable, 0.17 and 0.82, respectively. This approach demonstrates a useful extension of Bayesian methods that can easily be generalized to other study designs from simple (e.g., single factor ANOVA, paired t test) to more complicated block designs (e.g., crossover, split-plot). This approach is valuable for estimating the probabilities of restoration impacts or other management actions.

  19. Controlled fabrication of nanopores using a direct focused ion beam approach with back face particle detection.

    PubMed

    Patterson, N; Adams, D P; Hodges, V C; Vasile, M J; Michael, J R; Kotula, P G

    2008-06-11

    We report a direct, ion drilling technique that enables the reproducible fabrication and placement of nanopores in membranes of different thickness. Using a 30 keV focused Ga ion beam column combined with an in situ, back face, multi-channelplate particle detector, nanopores are sputtered in Si(3)N(4) and W/Si(3)N(4) to have diameters as small as 12 nm. Transmission electron microscopy shows that focused ion beam-drilled holes are near-conical with the diameter decreasing from entry to exit side. By monitoring the detector signal during ion exposure, the drilled hole width can be minimized such that the exit-side diameter is smaller than the full width at half-maximum of the nominally Gaussian-shaped incident beam. Judicious choice of the beam defining aperture combined with back face particle detection allows for reproducible exit-side hole diameters between 18 and 100 nm. The nanopore direct drilling technique does not require potentially damaging broad area exposure to tailor hole sizes. Moreover, this technique successfully achieves breakthrough despite the effects of varying membrane thickness, redeposition, polycrystalline grain structure, and slight ion beam current fluctuations.

  20. Acoustic characterization of high intensity focused ultrasound fields: A combined measurement and modeling approach

    PubMed Central

    Canney, Michael S.; Bailey, Michael R.; Crum, Lawrence A.; Khokhlova, Vera A.; Sapozhnikov, Oleg A.

    2008-01-01

    Acoustic characterization of high intensity focused ultrasound (HIFU) fields is important both for the accurate prediction of ultrasound induced bioeffects in tissues and for the development of regulatory standards for clinical HIFU devices. In this paper, a method to determine HIFU field parameters at and around the focus is proposed. Nonlinear pressure waveforms were measured and modeled in water and in a tissue-mimicking gel phantom for a 2 MHz transducer with an aperture and focal length of 4.4 cm. Measurements were performed with a fiber optic probe hydrophone at intensity levels up to 24 000 W∕cm2. The inputs to a Khokhlov–Zabolotskaya–Kuznetsov-type numerical model were determined based on experimental low amplitude beam plots. Strongly asymmetric waveforms with peak positive pressures up to 80 MPa and peak negative pressures up to 15 MPa were obtained both numerically and experimentally. Numerical simulations and experimental measurements agreed well; however, when steep shocks were present in the waveform at focal intensity levels higher than 6000 W∕cm2, lower values of the peak positive pressure were observed in the measured waveforms. This underrepresentation was attributed mainly to the limited hydrophone bandwidth of 100 MHz. It is shown that a combination of measurements and modeling is necessary to enable accurate characterization of HIFU fields. PMID:19062878

  1. Acoustic characterization of high intensity focused ultrasound fields: a combined measurement and modeling approach.

    PubMed

    Canney, Michael S; Bailey, Michael R; Crum, Lawrence A; Khokhlova, Vera A; Sapozhnikov, Oleg A

    2008-10-01

    Acoustic characterization of high intensity focused ultrasound (HIFU) fields is important both for the accurate prediction of ultrasound induced bioeffects in tissues and for the development of regulatory standards for clinical HIFU devices. In this paper, a method to determine HIFU field parameters at and around the focus is proposed. Nonlinear pressure waveforms were measured and modeled in water and in a tissue-mimicking gel phantom for a 2 MHz transducer with an aperture and focal length of 4.4 cm. Measurements were performed with a fiber optic probe hydrophone at intensity levels up to 24,000 W/cm(2). The inputs to a Khokhlov-Zabolotskaya-Kuznetsov-type numerical model were determined based on experimental low amplitude beam plots. Strongly asymmetric waveforms with peak positive pressures up to 80 MPa and peak negative pressures up to 15 MPa were obtained both numerically and experimentally. Numerical simulations and experimental measurements agreed well; however, when steep shocks were present in the waveform at focal intensity levels higher than 6000 W/cm(2), lower values of the peak positive pressure were observed in the measured waveforms. This underrepresentation was attributed mainly to the limited hydrophone bandwidth of 100 MHz. It is shown that a combination of measurements and modeling is necessary to enable accurate characterization of HIFU fields.

  2. New design approaches for a very high resolution spectrograph for the combined focus of the VLT

    NASA Astrophysics Data System (ADS)

    Spanò, Paolo; Delabre, Bernard; Dekker, Hans; Avila, Gerardo

    2008-07-01

    To achieve very-high spectral resolutions (R>100,000) with large telescopes (D>8m) new optical solutions have been investigated in the context of the ESPRESSO project for the VLT, starting from the initial design of CODEX for the E-ELT. ESPRESSO is a high-efficiency, high-stability, high-resolution visible spectrograph for the combined Coude focus of the VLT. Among these new solutions, we can mention: free-form optics, used to design an all-mirror anamorphic pupil slicer, large mosaic echelle grating, slanted VPH gratings, super-corrected atmospheric dispersion corrector. All these solutions have been usefully applied to design the spectrograph for ESPRESSO, and its Coude relay system.

  3. Size-Controlled Fabrication of Polyaniline Microfibers Based on 3D Hydrodynamic Focusing Approach.

    PubMed

    Yoo, Imsung; Song, Simon; Uh, Kyungchan; Lee, Chan Woo; Kim, Jong-Man

    2015-07-01

    Owing to the relatively high conductivity and unique redox behavior, polyaniline (PANI) has been one of the most technologically promising conducting polymers. Although various methodologies have been developed, fabrication of PANI microfibers has been a challenging task owing to the poor solubility in most organic solvents. By taking advantage of a microfluidic technology and organic soluble acid labile t-Boc-protected PANI (t-Boc-PANI) as the conducting polymer precursor, fabrication of PANI microfibers in a size-controlled manner is possible. Introduction of a THF solution containing t-Boc-PANI, and dodecylbenzenesulfonic acid (DBSA) as a core flow, and water as a sheath flow into a microfluidic channel with a 3D hydrodynamic focusing effect results in crystallization of the polymer fiber. By changing the flow rate, linear PANI microfibers that range from 16.2 to 39.4 μm in diameter are readily obtained.

  4. Current and future therapeutic approaches for metastatic pheochromocytoma and paraganglioma: focus on SDHB tumors

    PubMed Central

    Matro, Joey; Giubellino, Alessio; Pacak, Karel

    2012-01-01

    As a result of intense genetic studies of families with specific mutations, the road to better therapeutic intervention for pheochromocytoma (PHEOs) and parangangliomas (PGLs) has more recently become populated with several promising molecular targets. Consequently a change in paradigm from a previous view on nonspecific therapy has shifted towards more selective molecular targeted therapies. In particular, malignant PHEOs/PGLs, more specifically the tumors that result from mutations in succinate dehydrogenase subunit B (SDHB), are a clear concern, and novel therapies should be developed to address this problem. Here we summarize current and future therapeutic approaches. PMID:23322515

  5. Effective approach for calculations of absolute stability of proteins using focused dielectric constants.

    PubMed

    Vicatos, Spyridon; Roca, Maite; Warshel, Arieh

    2009-11-15

    The ability to predict the absolute stability of proteins based on their corresponding sequence and structure is a problem of great fundamental and practical importance. In this work, we report an extensive, refinement and validation of our recent approach (Roca et al., FEBS Lett 2007;581:2065-2071) for predicting absolute values of protein stability DeltaG(fold). This approach employs the semimacroscopic protein dipole Langevin dipole method in its linear response approximation version (PDLD/S-LRA) while using the best fitted values of the dielectric constants epsilon'(p) and epsilon'(eff) for the self energy and charge-charge interactions, respectively. The method is validated on a diverse set of 45 proteins. It is found that the best fitted values of both dielectric constants are around 40. However, the self energy of internal residues and the charge-charge interactions of Lys have to be treated with care, using a somewhat lower values of epsilon'(p) and epsilon'(eff). The predictions of DeltaG(fold) reported here, have an average error of only 1.8 kcal/mole compared to the observed values, making our method very promising for estimating protein stability. It also provides valuable insight into the complex electrostatic phenomena taking place in folded proteins.

  6. A Standardized, Bundled Approach to Providing Geriatric-Focused Acute Care

    PubMed Central

    Mattison, Melissa L.P.; Catic, Angela; Davis, Roger B.; Olveczky, Daniele; Moran, Julie; Yang, Julius; Aronson, Mark; Zeidel, Mark; Lipsitz, Lewis; Marcantonio, Edward R.

    2015-01-01

    Background Computerized provider order entry (CPOE) systems in the electronic medical record and checklists may present opportunities to improve care in older hospitalized adults. Objectives To determine if a bundled intervention can increase detection of delirium and facilitate safer use of high risk medications. Design Pre-post interventional trial Setting Large academic medical center Participants Patients ≥ 70 years (n=19,949) admitted 5/1/2008 to 9/30/2011. Patients ≥ 80 years admitted after 4/26/2010 received the intervention; those admitted prior were primary controls. Patients aged 70–79 were concurrent controls. Intervention The intervention uses a checklist promoting delirium prevention, recognition and management, and modifies the CPOE system to provide elder focused care. Measurements Frequency of orders for activating the rapid response team for altered mental status, frequency of orders for haloperidol > 0.5 mg or IV morphine > 2 mg, and discharge disposition. Results Patients receiving the intervention were 86.1 ± 4.6 years old and 58.2% female. The number of orders to activate the rapid response team for altered mental status increased in both patients receiving the bundle and in controls [odds ratio (OR) for the difference of differences = 1.23 (95% CI 0.68–2.24, p=0.49)]. Patients receiving the bundle were less likely to receive haloperidol > 0.5 mg IV/IM/PO [OR=0.60 (0.39–0.91) p = 0.02] and morphine > 2 mg IV [OR=0.52 (0.42–0.63), p < 0.0001]. More patients who received the bundle were discharged home than to extended care facilities [OR 1.18 (CI 1.04–1.35) p = 0.01]. Conclusion An intervention focused on delirium prevention and recognition by bedside staff combined with computerized decision support facilitates safer prescribing of high risk medications, and possibly results in less need for extended care. PMID:24749723

  7. NIMROD: A Customer Focused, Team Driven Approach for Fusion Code Development

    NASA Astrophysics Data System (ADS)

    Karandikar, H. M.; Schnack, D. D.

    1996-11-01

    NIMROD is a new code that will be used for the analysis of existing fusion experiments, prediction of operational limits, and design of future devices. An approach called Integrated Product Development (IPD) is being used for the development of NIMROD. It is a dramatic departure from existing practice in the fusion program. Code development is being done by a self-directed, multi-disciplinary, multi-institutional team that consists of experts in plasma theory, experiment, computational physics, and computer science. Customer representatives (ITER, US experiments) are an integral part of the team. The team is using techniques such as Quality Function Deployment (QFD), Pugh Concept Selection, Rapid Prototyping, and Risk Management, during the design phase of NIMROD. Extensive use is made of communication and internet technology to support collaborative work. Our experience with using these team techniques for such a complex software development project will be reported.

  8. A systems biology approach to nutritional immunology - focus on innate immunity.

    PubMed

    Afacan, Nicole J; Fjell, Christopher D; Hancock, Robert E W

    2012-02-01

    Innate immunity and nutrient metabolism are complex biological systems that must work in concert to sustain and preserve life. The effector cells of the innate immune system rely on essential nutrients to generate energy, produce metabolic precursors for macromolecule biosynthesis and tune their responses to infectious agents. Thus disruptions to nutritional status have a substantial impact on immune competence and can result in increased susceptibility to infection in the case of nutrient deficiency, or chronic inflammation in the case of over-nutrition. The traditional, reductionist methods used in the study of nutritional immunology are incapable of exploring the extremely complex interactions between nutrient metabolism and innate immunity. Here, we review a relatively new analytical approach, systems biology, and highlight how it can be applied to nutritional immunology to provide a comprehensive view of the mechanisms behind nutritional regulation of the innate immune system.

  9. Evaluation of approaches focused on modelling of organic carbon stocks using the RothC model

    NASA Astrophysics Data System (ADS)

    Koco, Štefan; Skalský, Rastislav; Makovníková, Jarmila; Tarasovičová, Zuzana; Barančíková, Gabriela

    2014-05-01

    The aim of current efforts in the European area is the protection of soil organic matter, which is included in all relevant documents related to the protection of soil. The use of modelling of organic carbon stocks for anticipated climate change, respectively for land management can significantly help in short and long-term forecasting of the state of soil organic matter. RothC model can be applied in the time period of several years to centuries and has been tested in long-term experiments within a large range of soil types and climatic conditions in Europe. For the initialization of the RothC model, knowledge about the carbon pool sizes is essential. Pool size characterization can be obtained from equilibrium model runs, but this approach is time consuming and tedious, especially for larger scale simulations. Due to this complexity we search for new possibilities how to simplify and accelerate this process. The paper presents a comparison of two approaches for SOC stocks modelling in the same area. The modelling has been carried out on the basis of unique input of land use, management and soil data for each simulation unit separately. We modeled 1617 simulation units of 1x1 km grid on the territory of agroclimatic region Žitný ostrov in the southwest of Slovakia. The first approach represents the creation of groups of simulation units based on the evaluation of results for simulation unit with similar input values. The groups were created after the testing and validation of modelling results for individual simulation units with results of modelling the average values of inputs for the whole group. Tests of equilibrium model for interval in the range 5 t.ha-1 from initial SOC stock showed minimal differences in results comparing with result for average value of whole interval. Management inputs data from plant residues and farmyard manure for modelling of carbon turnover were also the same for more simulation units. Combining these groups (intervals of initial

  10. A systemic approach to cancer treatment: tumor cell reprogramming focused on endocrine-related cancers.

    PubMed

    Biava, P M; Nicolini, A; Ferrari, P; Carpi, A; Sell, S

    2014-01-01

    The term "cancer cell reprogramming" is used to define any kind of intervention aimed at transforming cancer cells into terminally differentiated cells. Using this approach, new technologies have been applied with different methods for a more systemic approach to cancer treatment. This review reports on advances of these technologies, including our personal contributions, mainly carried out on endocrine-related cancers. Some of the interventions, aimed at reverting cancer cells into a normal phenotype, are based on the evidence that tumor development is suppressed by the embryonic microenvironment. On the basis of this rationale, experiments have been conducted using stem cell differentiation stage factors (SCDSFs) taken at different stages of development of Zebrafish embryos, oocyte extracts, or naïve human umbilical cord matrix derived stem cells (UMDSCs). SCDSFs induce significant growth inhibition on different tumor cell lines in vitro, likely because of increases in cell cycle regulatory molecules, such as p53 and pRb. Treatment with these factors activates apoptosis and differentiation related to caspase-3. This is achieved via p73 apoptotic-dependent pathway activation with a concurrent normalization of the E-cadherin and beta-catenin ratio. Extracts from prophase amphibian oocytes could reprogram relevant epigenetic alterations in MCF-7 and HCC1954 breast cancer cell lines, while un-engineered (naïve) human UMDSCs attenuated growth of MDA-231 human breast carcinoma cells. A product prepared for human treatments, containing SCDSFs at very low doses, yielded favorable results in breast cancer and in intermediate-advanced hepatocellular carcinoma. Other reprogramming interventions used in the models of breast, prostate and ovarian cancer cell lines are described. Finally, current and future perspectives of this novel technology are discussed and a new hallmark of cancer is suggested: the loss of differentiation of cancer cells.

  11. Translational approach to develop novel medications on alcohol addiction: Focus on neuropeptides

    PubMed Central

    Ubaldi, Massimo; Bifone, Angelo; Ciccocioppo, Roberto

    2013-01-01

    Research on alcohol and drug dependence has shown that the development of addiction depends on a complex interplay of psychological factors, genetic or epigenetic predisposing factors, and neurobiological adaptations induced by drug consumption. A greater understanding of the mechanisms leading to alcohol abuse will allow researchers to identify genetic variation that corresponds to a specific biological vulnerability to addiction, thus defining robust endophenotypes that might help deconstruct these complex syndromes into more tractable components. To this end, it is critical to develop a translational framework that links alterations at the molecular level, to changes in neuronal function, and ultimately to changes at the behavioral and clinical levels. Translational phenotypes can be identified by the combination of animal and human studies designed to elucidate the neurofunctional, anatomical and pharmacological mechanisms underlying the etiology of alcohol addiction. The present article offers an overview of medication development in alcoholism with a focus on the critical aspect of translational research. Moreover, significant examples of promising targets from neuropeptidergic systems, namely nociceptin/orphanin FQ and neuropeptide S are given. PMID:23648086

  12. Mediators of effects of a selective family-focused violence prevention approach for middle school students.

    PubMed

    2012-02-01

    This study examined how parenting and family characteristics targeted in a selective prevention program mediated effects on key youth proximal outcomes related to violence perpetration. The selective intervention was evaluated within the context of a multi-site trial involving random assignment of 37 schools to four conditions: a universal intervention composed of a student social-cognitive curriculum and teacher training, a selective family-focused intervention with a subset of high-risk students, a condition combining these two interventions, and a no-intervention control condition. Two cohorts of sixth-grade students (total N = 1,062) exhibiting high levels of aggression and social influence were the sample for this study. Analyses of pre-post change compared to controls using intent-to-treat analyses found no significant effects. However, estimates incorporating participation of those assigned to the intervention and predicted participation among those not assigned revealed significant positive effects on student aggression, use of aggressive strategies for conflict management, and parental estimation of student's valuing of achievement. Findings also indicated intervention effects on two targeted family processes: discipline practices and family cohesion. Mediation analyses found evidence that change in these processes mediated effects on some outcomes, notably aggressive behavior and valuing of school achievement. Results support the notion that changing parenting practices and the quality of family relationships can prevent the escalation in aggression and maintain positive school engagement for high-risk youth.

  13. Utilizing Focus Groups with Potential Participants and Their Parents: An Approach to Inform Study Design in a Large Clinical Trial

    PubMed Central

    Kadimpati, Sandeep; McCormick, Jennifer B; Chiu, Yichen; Parker, Ashley B.; Iftikhar, Aliya Z.; Flick, Randall P.; Warner, David O.

    2014-01-01

    Background In the recent literature, there has been some evidence that exposure of children to anesthetic procedures during the first two years of life may impair cognitive function and learning in later life. We planned a clinical study to quantify this risk, a study involving testing 1,000 children for neurodevelopmental deficits. As a part of this planning, we conducted focus groups involving potential participants and their parents to elicit information regarding three issues: communications with the community and potential participants, recruitment and consent processes, and the return of neurodevelopmental testing results. Methods Three focus groups were conducted with the parents of potential participants and one focus group was conducted with an 18-19 year old group; each group consisted of 6-10 participants. The moderated discussions had questions about recruitment, consenting issues, and expectations from the study about return of both overall trial findings and individual research test results. Results The focus group data gave us an insight on potential participants’ views on recruitment, consenting, communications about the study, and expectations about return of both overall trial findings and individual research test results. The concerns expressed were largely addressable. In addition, the concern we had about some parents enrolling their children in the study solely for the sake of getting their child's cognitive function results was dispelled. Conclusions We found that the individuals participating in our focus groups were generally enthusiastic about the large clinical study and could see the value in answering the study question. The data from the focus groups were used to inform changes to the recruitment and consent process. Focus group input was also instrumental in affirming the study design regarding return of results. Our experience suggests that the approach we used may serve as a model for other investigators to help inform the various

  14. Genomic approaches for designing durum wheat ready for climate change with a focus on drought.

    PubMed

    Habash, D Z; Kehel, Z; Nachit, M

    2009-01-01

    Climate change is projected to have a significant impact on temperature and precipitation profiles in the Mediterranean basin. The incidence and severity of drought will become commonplace and this will reduce the productivity of rain-fed crops such as durum wheat. Genetic diversity is the material basis for crop improvement and plant breeding has exploited naturally occurring variation to deliver cultivars with improved resistance to abiotic stresses. The coupling of new genomic tools, technologies, and resources with genetic approaches is essential to underpin wheat breeding through marker-assisted selection and hence mitigate climate change. Improvements in crop performance under abiotic stresses have primarily targeted yield-related traits and it is anticipated that the application of genomic technologies will introduce new target traits for consideration in wheat breeding for resistance to drought. Many traits relating to the plant's response and adaptation to drought are complex and multigenic, and quantitative genetics coupled with genomic technologies have the potential to dissect complex genetic traits and to identify regulatory loci, genes and networks. Full realization of our abilities to manipulate metabolism, transduction pathways, and transcription factors for crop improvement ultimately relies on our basic understanding of the regulation of plant networks at all levels of function.

  15. Novel Therapeutic Approach for Autism Spectrum Disorder: Focus on SHANK3

    PubMed Central

    Uchino, Shigeo; Waga, Chikako

    2015-01-01

    SHANK3 is a synaptic scaffolding protein and plays an important role in neuronal development. SHANK3 interacts with various synaptic molecules, including post-synaptic density-95 (PSD-95), homer and GluR1 AMPA receptor. SHANK3 gene is a causable gene of the Phelan- McDermid syndrome (also known as the 22q13.3 deletion syndrome), whose manifestation is global developmental delay and autistic behavior, especially shows severe speech and language deficit. Additionally since cumulative gene analysis in autistic subjects identified several mutations in SHANK3 gene, including deletion and duplication in a particular region, abnormality of SHANK3 gene is thought the be related with the neuropathology of autism spectrum disorder (ASD). We here review the recent findings in regard to the roles of SHANK3 in higher brain functions, molecular-biologic studies of the complex expression of Shank3 transcripts and production of SHANK3 isoforms, and behavioral studies of Shank3-mutant mice, including our recent findings, and discuss a novel therapeutic approach for ASD. PMID:26511836

  16. TERRORIST PROTECTION PLANNING USING A RELATIVE RISK REDUCTION APPROACH, SESSION VIII: TECHNOLOGY FORUM FOCUS GROUPS.

    SciTech Connect

    INDUSI,J.P.

    2003-06-16

    Since the events of 9/11, there have been considerable concerns and associated efforts to prevent or respond to acts of terrorism. Very often we hear calls to reduce the threat from or correct vulnerabilities to various terrorist acts. Others fall victim to anxiety over potential scenarios with the gravest of consequences involving hundreds of thousands of casualties. The problem is complicated by the fact that planners have limited, albeit in some cases significant, resources and less than perfect intelligence on potential terrorist plans. However, valuable resources must be used prudently to reduce the overall risk to the nation. A systematic approach to this process of asset allocation is to reduce the overall risk and not just an individual element of risk such as vulnerabilities. Hence, we define risk as a function of three variables: the threat (the likelihood and scenario of the terrorist act), the vulnerability (the vulnerability of potential targets to the threat), and the consequences (health and safety, economic, etc.) resulting from a successful terrorist scenario. Both the vulnerability and consequences from a postulated adversary scenario can be reasonably well estimated. However, the threat likelihood and scenarios are much more difficult to estimate. A possible path forward is to develop scenarios for each potential target in question using experts from many disciplines. This should yield a finite but large number of target-scenario pairs. The vulnerabilities and consequences for each are estimated and then ranked relative to one another. The resulting relative risk ranking will have targets near the top of the ranking for which the threat is estimated to be more likely, the vulnerability greatest, and the consequences the most grave. In the absence of perfect intelligence, this may be the best we can do.

  17. An innovative interdisciplinary approach to self-directed learning with a focus on the continuum of patient care.

    PubMed

    Faucher, Dina; Everson, Claire R

    2004-01-01

    Current regulatory review standards emphasize the hospital's role in providing continuum of care. Today, patient care staff must know more about the "continuum of care" concept so they can help patients more fully understand their treatment and take an active role in their own care. One of the challenges is finding creative and effective ways to get the message across to everyone on the staff. This article describes one approach to self-directed learning that takes into consideration individual learning styles and level of proficiency with a focus on the continuum of patient care.

  18. The Strength-Focused and Meaning-Oriented Approach to Resilience and Transformation (SMART): A body-mind-spirit approach to trauma management.

    PubMed

    Chan, Cecilia L W; Chan, Timothy H Y; Ng, Siv Man

    2006-01-01

    This article introduces the Strength-focused and Meaning- oriented Approach to Resilience and Transformation (SMART) as a model of crisis intervention, which aims at discovering inner strengths through meaning reconstruction. Limitations of conventional crisis management and current findings in post-traumatic growth research are discussed. Instead of adopting a pathological framework, the SMART approach holds a holistic view of health, employs facilitative strategies, and promotes dynamic coping. Intervention components include Eastern spiritual teachings, physical techniques such as yoga and meditation, and psycho-education that promotes meaning reconstruction. Efficacy of the SMART model is assessed with reference to two pilot studies conducted in Hong Kong at the time when the SARS pandemic caused widespread fear and anxiety in the community. Response to potential criticisms of the SMART model is attempted.

  19. Indirect Methods for Nuclear Reaction Data

    SciTech Connect

    Escher, J E; Dietrich, F S

    2005-11-18

    Several indirect approaches for obtaining reaction cross sections are briefly reviewed. The Surrogate Nuclear Reactions method, which aims at determining cross sections for compound-nuclear reactions, is discussed in some detail. The validity of the Weisskopf-Ewing approximation in the Surrogate approach is studied for the example of neutron-induced fission of an actinide nucleus.

  20. Indirect microbial detection

    NASA Technical Reports Server (NTRS)

    Wilkins, J. R.

    1980-01-01

    Indirect method for detection of microbial growth utilizes flow of charged particles across barrier that physically separated growing cells from electrodes and measures resulting difference in potential between two platinum electrodes. Technique allows simplified noncontact monitoring of all growth in highly infectious cultures or in critical biochemical studies.

  1. Nervous system development in Spinicaudata and Cyclestherida (Crustacea, Branchiopoda)--comparing two different modes of indirect development by using an event pairing approach.

    PubMed

    Fritsch, Martin; Richter, Stefan

    2012-07-01

    Cladocera are the ecologically most important group within the Branchiopoda. They are unquestionably branchiopods but their evolutionary origin remains unclear. One favored explanation of their origin is that they evolved from a reproductive larva of a clam shrimp-like ancestor. To reveal a transformation and identify (potential) changes in chronology (heterochrony), we investigated and compared the development of representatives of two clam shrimp taxa, one of the Spinicaudata (Leptestheria dahalacensis) and one of the Cyclestherida (Cyclestheria hislopi), the sister group of Cladocera. Both taxa develop indirectly although the exact modes are quite different. The development of the nervous system, labeled and analyzed using immunohistochemical techniques and confocal microscopy, and that of the external morphology, scanned with an electron microscope, was investigated. L. dahalacensis hatch as a free-swimming nauplius and the nervous system and external morphology develop gradually. In C. hislopi, on the other hand, several internal and external structures develop before the hatching of a nonswimming embryo-like larva which is still carried in a dorsal brood pouch. The development in L. dahalacensis is directed from anterior to posterior, whereas in C. hislopi a more synchronous anterior and posterior differentiation is present. A comparison of both developmental sequences gives us the first indications of the evolutionary transformation which the Cladocera may have undergone from a clam shrimp-like ancestor.

  2. Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.

    PubMed

    Mattsson, Niklas; Zegers, Ingrid; Andreasson, Ulf; Bjerke, Maria; Blankenstein, Marinus A; Bowser, Robert; Carrillo, Maria C; Gobom, Johan; Heath, Theresa; Jenkins, Rand; Jeromin, Andreas; Kaplow, June; Kidd, Daniel; Laterza, Omar F; Lockhart, Andrew; Lunn, Michael P; Martone, Robert L; Mills, Kevin; Pannee, Josef; Ratcliffe, Marianne; Shaw, Leslie M; Simon, Adam J; Soares, Holly; Teunissen, Charlotte E; Verbeek, Marcel M; Umek, Robert M; Vanderstichele, Hugo; Zetterberg, Henrik; Blennow, Kaj; Portelius, Erik

    2012-08-01

    Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in clinical settings, research and drug trials. However, their broad-scale use on different technology platforms is hampered by the lack of standardization at the level of sample handling, determination of concentrations of analytes and the absence of well-defined performance criteria for in vitro diagnostic or companion diagnostic assays, which influences the apparent concentration of the analytes measured and the subsequent interpretation of the data. There is a need for harmonization of CSF AD biomarker assays that can reliably, across centers, quantitate CSF biomarkers with high analytical precision, selectivity and stability over long time periods. In this position paper, we discuss reference procedures for the measurement of CSF AD biomarkers, especially amyloid β42 and tau. We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42.

  3. Scaling approach to tight-binding transport in realistic graphene devices: The case of transverse magnetic focusing

    NASA Astrophysics Data System (ADS)

    Beconcini, M.; Valentini, S.; Kumar, R. Krishna; Auton, G. H.; Geim, A. K.; Ponomarenko, L. A.; Polini, M.; Taddei, F.

    2016-09-01

    Ultraclean graphene sheets encapsulated between hexagonal boron nitride crystals host two-dimensional electron systems in which low-temperature transport is solely limited by the sample size. We revisit the theoretical problem of carrying out microscopic calculations of nonlocal ballistic transport in such micron-scale devices. By employing the Landauer-Büttiker scattering theory, we propose a scaling approach to tight-binding nonlocal transport in realistic graphene devices. We test our numerical method against experimental data on transverse magnetic focusing (TMF), a textbook example of nonlocal ballistic transport in the presence of a transverse magnetic field. This comparison enables a clear physical interpretation of all the observed features of the TMF signal, including its oscillating sign.

  4. Indirect land use change and biofuel policy

    NASA Astrophysics Data System (ADS)

    Kocoloski, Matthew; Griffin, W. Michael; Matthews, H. Scott

    2009-09-01

    Biofuel debates often focus heavily on carbon emissions, with parties arguing for (or against) biofuels solely on the basis of whether the greenhouse gas emissions of biofuels are less than (or greater than) those of gasoline. Recent studies argue that land use change leads to significant greenhouse gas emissions, making some biofuels more carbon intensive than gasoline. We argue that evaluating the suitability and utility of biofuels or any alternative energy source within the limited framework of plus and minus carbon emissions is too narrow an approach. Biofuels have numerous impacts, and policy makers should seek compromises rather than relying solely on carbon emissions to determine policy. Here, we estimate that cellulosic ethanol, despite having potentially higher life cycle CO2 emissions (including from land use) than gasoline, would still be cost-effective at a CO2 price of 80 per ton or less, well above estimated CO2 mitigation costs for many alternatives. As an example of the broader approach to biofuel policy, we suggest the possibility of using the potential cost reductions of cellulosic ethanol relative to gasoline to balance out additional carbon emissions resulting from indirect land use change as an example of ways in which policies could be used to arrive at workable solutions.

  5. An Indirect Route for Ethanol Production

    SciTech Connect

    Eggeman, T.; Verser, D.; Weber, E.

    2005-04-29

    The ZeaChem indirect method is a radically new approach to producing fuel ethanol from renewable resources. Sugar and syngas processing platforms are combined in a novel way that allows all fractions of biomass feedstocks (e.g. carbohydrates, lignins, etc.) to contribute their energy directly into the ethanol product via fermentation and hydrogen based chemical process technologies. The goals of this project were: (1) Collect engineering data necessary for scale-up of the indirect route for ethanol production, and (2) Produce process and economic models to guide the development effort. Both goals were successfully accomplished. The projected economics of the Base Case developed in this work are comparable to today's corn based ethanol technology. Sensitivity analysis shows that significant improvements in economics for the indirect route would result if a biomass feedstock rather that starch hydrolyzate were used as the carbohydrate source. The energy ratio, defined as the ratio of green energy produced divided by the amount of fossil energy consumed, is projected to be 3.11 to 12.32 for the indirect route depending upon the details of implementation. Conventional technology has an energy ratio of 1.34, thus the indirect route will have a significant environmental advantage over today's technology. Energy savings of 7.48 trillion Btu/yr will result when 100 MMgal/yr (neat) of ethanol capacity via the indirect route is placed on-line by the year 2010.

  6. Biomass Indirect Liquefaction Strategy Workshop Summary Report

    SciTech Connect

    none,

    2014-07-01

    This report is based on the proceedings of the U.S. Department of Energy Bioenergy Technologies Office Biomass Indirect Liquefaction Strategy Workshop. The workshop, held March 20–21, 2014, in Golden, Colorado, discussed and detailed the research and development needs for biomass indirect liquefaction. Discussions focused on pathways that convert biomass-based syngas (or any carbon monoxide, hydrogen gaseous stream) to liquid intermediates (alcohols or acids) and further synthesize those intermediates to liquid hydrocarbons that are compatible as either a refinery feed or neat fuel.

  7. Novel approaches for the treatment of psychostimulant and opioid abuse – focus on opioid receptor-based therapies

    PubMed Central

    Bailey, Chris P.; Husbands, Steve M.

    2015-01-01

    Introduction Psychostimulant and opioid addiction are poorly treated. The majority of abstinent users relapse back to drug-taking within a year of abstinence, making ‘anti-relapse’ therapies the focus of much current research. There are two fundamental challenges to developing novel treatments for drug addiction. Firstly, there are 3 key stimuli that precipitate relapse back to drug-taking: stress, presentation of drug-conditioned cue, taking a small dose of drug. The most successful novel treatment would be effective against all 3 stimuli. Secondly, a large number of drug users are poly-drug users: taking more than one drug of abuse at a time. The ideal anti-addiction treatment would therefore be effective against all classes of drugs of abuse. Areas Covered In this review, the authors discuss the clinical need and animal models used to uncover potential novel treatments. There is a very broad range of potential treatment approaches and targets currently being examined as potential anti-relapse therapies. These broadly fit into 2 categories: ‘memory-based’ and ‘receptor-based’ and the authors discuss the key targets here within. Expert opinion Opioid receptors and ligands have been widely studied, and research into how different opioid subtypes affect behaviours related to addiction (reward, dysphoria, motivation) suggests that they are tractable targets as anti-relapse treatments. Regarding opioid ligands as novel ‘anti-relapse’ medications targets - research suggests that a ‘non-selective’ approach to targeting opioid receptors will be the most effective. PMID:25253272

  8. A unified approach to combine temperature estimation and elastography for thermal lesion determination in focused ultrasound thermal therapy

    NASA Astrophysics Data System (ADS)

    Liu, Hao-Li; Li, Meng-Lin; Tsui, Po-Hsiang; Lin, Ming-Shi; Huang, Sheng-Min; Bai, Jing

    2011-01-01

    Sonogram-based temperature estimation and elastography have both shown promise as methods of monitoring focused ultrasound (FUS) treatments to induce thermal ablation in tissue. However, each method has important limitations. Temperature estimates based on echo delays become invalid when the relationship between sound speed and temperature is nonlinear, and are further complicated by thermal expansion and other changes in tissue. Elastography can track thermal lesion formation over a wider range of elasticity, but with low specificity and high noise. Furthermore, this method is poor at small lesion detection. This study proposes integrating the two estimates to improve the quality of monitoring FUS-induced thermal lesions. Our unified computational kernel is tested on three types of phantoms. Experiments with type I and type II phantoms were conducted to calibrate the thermal mapping and elastography methods, respectively. The optimal settings were then used in experiments with the type III phantom, which contains ex vivo swine liver tissue. Three different spatial-peak temporal-average intensities (Ispta; 35, 133 and 240 W cm-2) were delivered with a sonication time of 60 s. The new procedure can closely monitor heating while identifying the dimensions of the thermal lesion, and is significantly better at the latter task than either approach alone. This work may help improve the current clinical practice, which employs sonograms to guide the FUS-induced thermal ablation procedure.

  9. A unified approach to combine temperature estimation and elastography for thermal lesion determination in focused ultrasound thermal therapy.

    PubMed

    Liu, Hao-Li; Li, Meng-Lin; Tsui, Po-Hsiang; Lin, Ming-Shi; Huang, Sheng-Min; Bai, Jing

    2011-01-07

    Sonogram-based temperature estimation and elastography have both shown promise as methods of monitoring focused ultrasound (FUS) treatments to induce thermal ablation in tissue. However, each method has important limitations. Temperature estimates based on echo delays become invalid when the relationship between sound speed and temperature is nonlinear, and are further complicated by thermal expansion and other changes in tissue. Elastography can track thermal lesion formation over a wider range of elasticity, but with low specificity and high noise. Furthermore, this method is poor at small lesion detection. This study proposes integrating the two estimates to improve the quality of monitoring FUS-induced thermal lesions. Our unified computational kernel is tested on three types of phantoms. Experiments with type I and type II phantoms were conducted to calibrate the thermal mapping and elastography methods, respectively. The optimal settings were then used in experiments with the type III phantom, which contains ex vivo swine liver tissue. Three different spatial-peak temporal-average intensities (I(spta); 35, 133 and 240 W cm(-2)) were delivered with a sonication time of 60 s. The new procedure can closely monitor heating while identifying the dimensions of the thermal lesion, and is significantly better at the latter task than either approach alone. This work may help improve the current clinical practice, which employs sonograms to guide the FUS-induced thermal ablation procedure.

  10. [Indirect costs in idiopathic Parkinson's disease].

    PubMed

    Barth, F; Baum, B; Bremen, D; Meuser, T; Jost, W H

    2005-04-01

    The economic impact of parkinsonism has been getting more significant due to the increasing prevalence of Parkinson's disease and the modern therapies available nowadays. The present study is supposed to update the existing databases and to provide a sound foundation for rational decision-making in the health care sector. It does not only focus on the direct costs of this disease incurred by 75 patients over a longer period, but also and for the first time, takes a look on the indirect cost as well. The study shows that the expenses for PD-related house rebuilding and early retirement make up for a substantial share among the indirect costs. In the overall analysis, the ratio between both, direct and indirect costs appear to be relatively balanced with slight domination of the direct costs.

  11. Conducting indirect-treatment-comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 2.

    PubMed

    Hoaglin, David C; Hawkins, Neil; Jansen, Jeroen P; Scott, David A; Itzler, Robbin; Cappelleri, Joseph C; Boersma, Cornelis; Thompson, David; Larholt, Kay M; Diaz, Mireya; Barrett, Annabel

    2011-06-01

    Evidence-based health care decision making requires comparison of all relevant competing interventions. In the absence of randomized controlled trials involving a direct comparison of all treatments of interest, indirect treatment comparisons and network meta-analysis provide useful evidence for judiciously selecting the best treatment(s). Mixed treatment comparisons, a special case of network meta-analysis, combine direct evidence and indirect evidence for particular pairwise comparisons, thereby synthesizing a greater share of the available evidence than traditional meta-analysis. This report from the International Society for Pharmacoeconomics and Outcomes Research Indirect Treatment Comparisons Good Research Practices Task Force provides guidance on technical aspects of conducting network meta-analyses (our use of this term includes most methods that involve meta-analysis in the context of a network of evidence). We start with a discussion of strategies for developing networks of evidence. Next we briefly review assumptions of network meta-analysis. Then we focus on the statistical analysis of the data: objectives, models (fixed-effects and random-effects), frequentist versus Bayesian approaches, and model validation. A checklist highlights key components of network meta-analysis, and substantial examples illustrate indirect treatment comparisons (both frequentist and Bayesian approaches) and network meta-analysis. A further section discusses eight key areas for future research.

  12. The FIGS (Focused Identification of Germplasm Strategy) Approach Identifies Traits Related to Drought Adaptation in Vicia faba Genetic Resources

    PubMed Central

    Khazaei, Hamid; Street, Kenneth; Bari, Abdallah; Mackay, Michael; Stoddard, Frederick L.

    2013-01-01

    Efficient methods to explore plant agro-biodiversity for climate change adaptive traits are urgently required. The focused identification of germplasm strategy (FIGS) is one such approach. FIGS works on the premise that germplasm is likely to reflect the selection pressures of the environment in which it developed. Environmental parameters describing plant germplasm collection sites are used as selection criteria to improve the probability of uncovering useful variation. This study was designed to test the effectiveness of FIGS to search a large faba bean (Vicia faba L.) collection for traits related to drought adaptation. Two sets of faba bean accessions were created, one from moisture-limited environments, and the other from wetter sites. The two sets were grown under well watered conditions and leaf morpho-physiological traits related to plant water use were measured. Machine-learning algorithms split the accessions into two groups based on the evaluation data and the groups created by this process were compared to the original climate-based FIGS sets. The sets defined by trait data were in almost perfect agreement to the FIGS sets, demonstrating that ecotypic differentiation driven by moisture availability has occurred within the faba bean genepool. Leaflet and canopy temperature as well as relative water content contributed more than other traits to the discrimination between sets, indicating that their utility as drought-tolerance selection criteria for faba bean germplasm. This study supports the assertion that FIGS could be an effective tool to enhance the discovery of new genes for abiotic stress adaptation. PMID:23667581

  13. Regularized focusing inversion of time-lapse electrical resistivity data: an approach to parametrize the minimum gradient support functional

    NASA Astrophysics Data System (ADS)

    Nguyen, Frédéric; Hermans, Thomas

    2015-04-01

    Inversion of time-lapse resistivity data allows obtaining 'snapshots' of changes occurring in monitored systems for applications such as aquifer storage, geothermal heat exchange, site remediation or tracer tests. Based on these snapshots, one can infer qualitative information on the location and morphology of changes occurring in the subsurface but also quantitative estimates on the degree of changes in certain property such as temperature or total dissolved solid content. Analysis of these changes can provide direct insight into flow and transport and associated processes and controlling parameters. However, the reliability of the analysis is dependent on survey geometry, measurement schemes, data error, and regularization. Survey design parameters may be optimized prior to the monitoring survey. Regularization, on the other hand, may be chosen depending on available information collected during the monitoring. Common approaches consider smoothing model changes both in space and time but it is often needed to obtain a sharp temporal anomaly, for example in fractured aquifers. We here propose to use the alternative regularization approach based on minimum gradient support (MGS) (Zhdanov, 2002) for time-lapse surveys which will focus the changes in tomograms snapshots. MGS will limit the occurrences of changes in electrical resistivity but will also restrict the variations of these changes inside the different zones. A commonly encountered difficulty by practitioners in this type of regularization is the choice of an additional parameter, the so-called β, required to define the MGS functional. To the best of our knowledge, there is no commonly accepted or standard methodology to optimize the MGS parameter β. The inversion algorithm used in this study is CRTomo (Kemna 2000). It uses a Gauss-Newton scheme to iteratively minimize an objective function which consists of a data misfit functional and a model constraint functional. A univariate line search is performed

  14. Indirect combustion noise of auxiliary power units

    NASA Astrophysics Data System (ADS)

    Tam, Christopher K. W.; Parrish, Sarah A.; Xu, Jun; Schuster, Bill

    2013-08-01

    Recent advances in noise suppression technology have significantly reduced jet and fan noise from commercial jet engines. This leads many investigators in the aeroacoustics community to suggest that core noise could well be the next aircraft noise barrier. Core noise consists of turbine noise and combustion noise. There is direct combustion noise generated by the combustion processes, and there is indirect combustion noise generated by the passage of combustion hot spots, or entropy waves, through constrictions in an engine. The present work focuses on indirect combustion noise. Indirect combustion noise has now been found in laboratory experiments. The primary objective of this work is to investigate whether indirect combustion noise is also generated in jet and other engines. In a jet engine, there are numerous noise sources. This makes the identification of indirect combustion noise a formidable task. Here, our effort concentrates exclusively on auxiliary power units (APUs). This choice is motivated by the fact that APUs are relatively simple engines with only a few noise sources. It is, therefore, expected that the chance of success is higher. Accordingly, a theoretical model study of the generation of indirect combustion noise in an Auxiliary Power Unit (APU) is carried out. The cross-sectional areas of an APU from the combustor to the turbine exit are scaled off to form an equivalent nozzle. A principal function of a turbine in an APU is to extract mechanical energy from the flow stream through the exertion of a resistive force. Therefore, the turbine is modeled by adding a negative body force to the momentum equation. This model is used to predict the ranges of frequencies over which there is a high probability for indirect combustion noise generation. Experimental spectra of internal pressure fluctuations and far-field noise of an RE220 APU are examined to identify anomalous peaks. These peaks are possible indirection combustion noise. In the case of the

  15. Assessing Mediational Models: Testing and Interval Estimation for Indirect Effects

    ERIC Educational Resources Information Center

    Biesanz, Jeremy C.; Falk, Carl F.; Savalei, Victoria

    2010-01-01

    Theoretical models specifying indirect or mediated effects are common in the social sciences. An indirect effect exists when an independent variable's influence on the dependent variable is mediated through an intervening variable. Classic approaches to assessing such mediational hypotheses (Baron & Kenny, 1986; Sobel, 1982) have in recent years…

  16. Influence Operations: Redefining the Indirect Approach

    DTIC Science & Technology

    2011-06-01

    cut Lima from mines in Junín and Pasco. In August, a Jesuit -run development and educational center was destroyed in Jarpa, along with communal farms...Today Show News Report on Hezbollah’s Theme Park483 The theme park‘s documentary provides a glimpse of its multi-tiered influence effects...memorials incorporating personalized documentaries in other countries. The park provides a three-dimensional medium that freezes an astutely cultivated

  17. Afghanistan, Counterinsurgency, and the Indirect Approach

    DTIC Science & Technology

    2010-04-01

    alienate them through highhandedness, villainy, or cruelty . Thus the American way of COIN flows directly into social-reen- gineering of societies with a...the American deployment.106 On Jolo Island, the U.S. military showed animated films to children, who got a bottle of water and paper bag of popcorn in

  18. Should HIV testing for all pregnant women continue? Cost-effectiveness of universal antenatal testing compared to focused approaches across high to very low HIV prevalence settings

    PubMed Central

    Ishikawa, Naoko; Dalal, Shona; Johnson, Cheryl; Hogan, Daniel R; Shimbo, Takuro; Shaffer, Nathan; Pendse, Razia N; Lo, Ying-Ru; Ghidinelli, Massimo N; Baggaley, Rachel

    2016-01-01

    Introduction HIV testing is the entry point for the elimination of mother-to-child transmission of HIV. Decreasing external funding for the HIV response in some low- and middle-income countries has triggered the question of whether a focused approach to HIV testing targeting pregnant women in high-burden areas should be considered. This study aimed at determining and comparing the cost-effectiveness of universal and focused HIV testing approaches for pregnant women across high to very low HIV prevalence settings. Methods We conducted a modelling analysis on health and cost outcomes of HIV testing for pregnant women using four country-based case scenarios (Namibia, Kenya, Haiti and Viet Nam) to illustrate high, intermediate, low and very low HIV prevalence settings. We used subnational prevalence data to divide each country into high-, medium- and low-burden areas, and modelled different antenatal and testing coverage in each. Results When HIV testing services were only focused in high-burden areas within a country, mother-to-child transmission rates remained high ranging from 18 to 23%, resulting in a 25 to 69% increase in new paediatric HIV infections and increased future treatment costs for children. Universal HIV testing was found to be dominant (i.e. more QALYs gained with less cost) compared to focused approaches in the Namibia, Kenya and Haiti scenarios. The universal approach was also very cost-effective compared to focused approaches, with $ 125 per quality-adjusted life years gained in the Viet Nam-based scenario of very low HIV prevalence. Sensitivity analysis further supported the findings. Conclusions Universal approach to antenatal HIV testing achieves the best health outcomes and is cost-saving or cost-effective in the long term across the range of HIV prevalence settings. It is further a prerequisite for quality maternal and child healthcare and for the elimination of mother-to-child transmission of HIV. PMID:27978939

  19. Solution-Focused Approaches in the Practice of UK Educational Psychologists: A Study of the Nature of Their Application and Evidence of Their Effectiveness

    ERIC Educational Resources Information Center

    Stobie, Ingeborg; Boyle, James; Woolfson, Lisa

    2005-01-01

    Solution-focused approaches are increasingly widely used in the practice of the applied educational psychologist (EP) (Ajmal and Rees, 2001; Durrant, 1993; Redpath and Harper, 1999; Rhodes and Ajmal, 1995). Based on a small-scale computer-mediated exploratory survey, this article examines the nature of such practice and investigates whether and…

  20. The Native Telehealth Outreach and Technical Assistance Program: A Community-Based Approach to the Development of Multimedia-Focused Health Care Information

    ERIC Educational Resources Information Center

    Dick, Rhonda Wiegman; Manson, Spero M.; Hansen, Amy L.; Huggins, Annie; Trullinger, Lori

    2007-01-01

    The development and dissemination of culturally relevant health care information has traditionally taken a "top-down" approach. Governmental funding agencies and research institutions have too often dictated the importance and focus of health-related research and information dissemination. In addition, the digital divide has affected rural…

  1. Through a Different Lens: Reflecting on a Strengths-Based, Talent-Focused Approach for Twice-Exceptional Learners

    ERIC Educational Resources Information Center

    Baum, Susan M.; Schader, Robin M.; Hébert, Thomas P.

    2014-01-01

    This study sought to understand the experiences of a cohort of students who entered a strengths-based private school for twice-exceptional students during middle school and successfully completed graduation requirements. Using a case study design, the researchers analyzed data collected from student and teacher interviews, parent focus groups,…

  2. Barriers and Solutions to Recruitment Strategies of Students into Post-Secondary Agricultural Education Programs: A Focus Group Approach

    ERIC Educational Resources Information Center

    Calvin, Jennifer; Pense, Seburn L.

    2013-01-01

    This qualitative study utilized focus group interviews of secondary Illinois agricultural education teachers to investigate the continuing problem of student recruitment into teacher preparation pro-grams of agricultural education. Using signal theory, image theory and person-organization fit theory, the researchers identified five themes relating…

  3. Back Translating: An Integrated Approach to Focus Learners' Attention on Their L2 Knowledge Gaps

    ERIC Educational Resources Information Center

    Zhang, Yun; Gao, Cun

    2014-01-01

    Integration of the four language skills can be enhanced by focusing on back translating--translating an English text into the students' first language and then back into English. This article describes a three-step process for using back translation in reading classes as a way to help students identify gaps in their English competence.

  4. Pilot Study in the Development of an Interactive Multimedia Learning Environment for Sexual Health Interventions: A Focus Group Approach

    ERIC Educational Resources Information Center

    Goold, P. C.; Bustard, S.; Ferguson, E.; Carlin, E. M.; Neal, K.; Bowman, C. A.

    2006-01-01

    In the UK there are high rates of sexually transmitted infections and unintended pregnancies amongst young people. There is limited and contradictory evidence that current sexual health education interventions are effective or that they improve access to appropriate sexual health services. This paper describes the outcome of focus group work with…

  5. Qualitative Inquiry into Church-Based Assets for HIV/AIDS Prevention and Control: A Forum Focus Group Discussion Approach

    ERIC Educational Resources Information Center

    Aja, Godwin N.; Modeste, Naomi N.; Montgomery, Susanne B.

    2012-01-01

    Assets church members believed they needed to engage in effective HIV/AIDS prevention and control activities. We used the three-step forum focus group discussion (FFGD) methodology to elicit responses from 32 church leaders and lay members, representing five denominations in Aba, Nigeria. Concrete resources, health expertise, finances,…

  6. A Tailored Approach to Launch Community Coalitions Focused on Achieving Structural Changes: Lessons Learned From a HIV Prevention Mobilization Study.

    PubMed

    Chutuape, Kate S; Willard, Nancy; Walker, Bendu C; Boyer, Cherrie B; Ellen, Jonathan

    2015-01-01

    Public health HIV prevention efforts have begun to focus on addressing social and structural factors contributing to HIV risk, such as unstable housing, unemployment, and access to health care. With a limited body of evidence-based structural interventions for HIV, communities tasked with developing structural changes need a defined process to clarify their purpose and goals. This article describes the adaptations made to a coalition development model with the purpose of improving the start-up phase for a second group of coalitions. Modifications focused on preparing coalitions to more efficiently apply structural change concepts to their strategic planning activities, create more objectives that met study goals, and enhance coalition procedures such as building distributed coalition leadership to better support the mobilization process. We report on primary modifications to the process, findings for the coalitions, and recommendations for public health practitioners who are seeking to start a similar coalition.

  7. A Tailored Approach to Launch Community Coalitions Focused on Achieving Structural Changes: Lessons Learned from a HIV Prevention Mobilization Study

    PubMed Central

    Chutuape, Kate S.; Willard, Nancy; Walker, Bendu C.; Boyer, Cherrie B.; Ellen, Jonathan

    2014-01-01

    Public health HIV prevention efforts have begun to focus on addressing social and structural factors contributing to HIV risk, such as unstable housing, unemployment and access to healthcare. With a limited body of evidence-based structural interventions for HIV, communities tasked with developing structural changes need a defined process to clarify their purpose and goals. This paper describes the adaptations made to a coalition development model with the purpose of improving the start-up phase for a second group of coalitions. Modifications focused on preparing coalitions to more efficiently apply structural change concepts to their strategic planning activities, create more objectives that met study goals, and enhance coalition procedures, such as building distributed coalition leadership, to better support the mobilization process. We report on primary modifications to the process, findings for the coalitions and recommendations for public health practitioners that are seeking to start a similar coalition. PMID:26785397

  8. Reshaping the Focus and Structure of Vocational Teacher Education and Training Strategy in Lithuania--A Systematic Approach

    ERIC Educational Resources Information Center

    Kestutis, Pukelis; Lauzackas, Rimantas

    2004-01-01

    In this article the contemporary state of pedagogical qualification of Lithuanian vocational teachers is discussed. The new role of VET teacher and VET school in vocational teacher training, following the lifelong learning paradigm, are discussed. Main approaches, principles and parameters of the new vocational teacher training strategy in…

  9. Assessing the children's views on foods and consumption of selected food groups: outcome from focus group approach

    PubMed Central

    Sharif Ishak, Sharifah Intan Zainun; Kandiah, Mirnalini

    2013-01-01

    The food choices in childhood have high a probability of being carried through into their adulthood life, which then contributes to the risk of many non-communicable diseases. Therefore, there is a need to gather some information about children's views on foods which may influence their food choices for planning a related dietary intervention or programme. This paper aimed to explore the views of children on foods and the types of foods which are usually consumed by children under four food groups (snacks, fast foods, cereals and cereal products; and milk and dairy products) by using focus group discussions. A total of 33 school children aged 7-9 years old from Selangor and Kuala Lumpur participated in the focus groups. Focus groups were audio-taped, transcribed and analyzed according to the listed themes. The outcomes show that the children usually consumed snacks such as white bread with spread or as a sandwich, local cakes, fruits such as papaya, mango and watermelon, biscuits or cookies, tea, chocolate drink and instant noodles. Their choices of fast foods included pizza, burgers, French fries and fried chicken. For cereal products, they usually consumed rice, bread and ready-to-eat cereals. Finally, their choices of dairy products included milk, cheese and yogurt. The reasons for the food liking were taste, nutritional value and the characteristics of food. The outcome of this study may provide additional information on the food choices among Malaysian children, especially in urban areas with regard to the food groups which have shown to have a relationship with the risk of childhood obesity. PMID:23610606

  10. Assessing the children's views on foods and consumption of selected food groups: outcome from focus group approach.

    PubMed

    Sharif Ishak, Sharifah Intan Zainun; Shohaimi, Shamarina; Kandiah, Mirnalini

    2013-04-01

    The food choices in childhood have high a probability of being carried through into their adulthood life, which then contributes to the risk of many non-communicable diseases. Therefore, there is a need to gather some information about children's views on foods which may influence their food choices for planning a related dietary intervention or programme. This paper aimed to explore the views of children on foods and the types of foods which are usually consumed by children under four food groups (snacks, fast foods, cereals and cereal products; and milk and dairy products) by using focus group discussions. A total of 33 school children aged 7-9 years old from Selangor and Kuala Lumpur participated in the focus groups. Focus groups were audio-taped, transcribed and analyzed according to the listed themes. The outcomes show that the children usually consumed snacks such as white bread with spread or as a sandwich, local cakes, fruits such as papaya, mango and watermelon, biscuits or cookies, tea, chocolate drink and instant noodles. Their choices of fast foods included pizza, burgers, French fries and fried chicken. For cereal products, they usually consumed rice, bread and ready-to-eat cereals. Finally, their choices of dairy products included milk, cheese and yogurt. The reasons for the food liking were taste, nutritional value and the characteristics of food. The outcome of this study may provide additional information on the food choices among Malaysian children, especially in urban areas with regard to the food groups which have shown to have a relationship with the risk of childhood obesity.

  11. Separating astrophysical sources from indirect dark matter signals

    PubMed Central

    Siegal-Gaskins, Jennifer M.

    2015-01-01

    Indirect searches for products of dark matter annihilation and decay face the challenge of identifying an uncertain and subdominant signal in the presence of uncertain backgrounds. Two valuable approaches to this problem are (i) using analysis methods which take advantage of different features in the energy spectrum and angular distribution of the signal and backgrounds and (ii) more accurately characterizing backgrounds, which allows for more robust identification of possible signals. These two approaches are complementary and can be significantly strengthened when used together. I review the status of indirect searches with gamma rays using two promising targets, the Inner Galaxy and the isotropic gamma-ray background. For both targets, uncertainties in the properties of backgrounds are a major limitation to the sensitivity of indirect searches. I then highlight approaches which can enhance the sensitivity of indirect searches using these targets. PMID:25304638

  12. Separating astrophysical sources from indirect dark matter signals.

    PubMed

    Siegal-Gaskins, Jennifer M

    2015-10-06

    Indirect searches for products of dark matter annihilation and decay face the challenge of identifying an uncertain and subdominant signal in the presence of uncertain backgrounds. Two valuable approaches to this problem are (i) using analysis methods which take advantage of different features in the energy spectrum and angular distribution of the signal and backgrounds and (ii) more accurately characterizing backgrounds, which allows for more robust identification of possible signals. These two approaches are complementary and can be significantly strengthened when used together. I review the status of indirect searches with gamma rays using two promising targets, the Inner Galaxy and the isotropic gamma-ray background. For both targets, uncertainties in the properties of backgrounds are a major limitation to the sensitivity of indirect searches. I then highlight approaches which can enhance the sensitivity of indirect searches using these targets.

  13. Mixed Waste Focus Area Working Group: An Integrated Approach to Mercury Waste Treatment and Disposal. Revision 1

    SciTech Connect

    Morris, M.I.; Conley, T.B.; Osborne-Lee, I.W.

    1997-09-08

    May 1996, the U.S. Department of Energy (DOE) Mixed Waste Focus Area (MWFA) initiated the Mercury Work Group (HgWG). The HgWG was established to address and resolve the issues associated with Mercury- contaminated mixed wastes (MWs). During the initial technical baseline development process of the MWFA, three of the top four technology deficiencies identified were related to (1) amalgamation, (2) stabilization, and (3) separation and removal for the treatment of mercury and mercury-contaminated mixed waste (MW). The HgWG is assisting the MWFA in soliciting, identifying, initiating, and managing efforts to address these needs.

  14. Radiation reaction effects in cascade scattering of intense, tightly focused laser pulses by relativistic electrons: Classical approach

    NASA Astrophysics Data System (ADS)

    Zhidkov, A.; Masuda, S.; Bulanov, S. S.; Koga, J.; Hosokai, T.; Kodama, R.

    2014-05-01

    Nonlinear cascade scattering of intense, tightly focused laser pulses by relativistic electrons is studied numerically in the classical approximation including radiation damping for the quantum parameter ⟨ℏωxray⟩/ɛ <1 and an arbitrary radiation parameter χ. The electron's energy loss, along with its being scattered to the side by the ponderomotive force, makes scattering in the vicinity of a high laser field nearly impossible at high electron energies. The use of a second, copropagating laser pulse as a booster is shown to partially solve this problem.

  15. Reconstructing direct and indirect interactions in networked public goods game

    NASA Astrophysics Data System (ADS)

    Han, Xiao; Shen, Zhesi; Wang, Wen-Xu; Lai, Ying-Cheng; Grebogi, Celso

    2016-07-01

    Network reconstruction is a fundamental problem for understanding many complex systems with unknown interaction structures. In many complex systems, there are indirect interactions between two individuals without immediate connection but with common neighbors. Despite recent advances in network reconstruction, we continue to lack an approach for reconstructing complex networks with indirect interactions. Here we introduce a two-step strategy to resolve the reconstruction problem, where in the first step, we recover both direct and indirect interactions by employing the Lasso to solve a sparse signal reconstruction problem, and in the second step, we use matrix transformation and optimization to distinguish between direct and indirect interactions. The network structure corresponding to direct interactions can be fully uncovered. We exploit the public goods game occurring on complex networks as a paradigm for characterizing indirect interactions and test our reconstruction approach. We find that high reconstruction accuracy can be achieved for both homogeneous and heterogeneous networks, and a number of empirical networks in spite of insufficient data measurement contaminated by noise. Although a general framework for reconstructing complex networks with arbitrary types of indirect interactions is yet lacking, our approach opens new routes to separate direct and indirect interactions in a representative complex system.

  16. When is success not satisfying? Integrating regulatory focus and approach/avoidance motivation theories to explain the relation between core self-evaluation and job satisfaction.

    PubMed

    Ferris, D Lance; Johnson, Russell E; Rosen, Christopher C; Djurdjevic, Emilija; Chang, Chu-Hsiang Daisy; Tan, James A

    2013-03-01

    Integrating implications from regulatory focus and approach/avoidance motivation theories, we present a framework wherein motivational orientations toward positive (approach motivation orientation) or negative (avoidance motivation orientation) stimuli interact with workplace success to mediate the relation of core self-evaluation (CSE) with job satisfaction. Using data collected from supervisor-subordinate dyads (Sample 1) and time-lagged data (Sample 2), we found that the results from two studies indicated that the interaction of workplace success and avoidance motivation orientation mediated relations of CSE with job satisfaction. Although approach motivation orientation did not interact with workplace success, it did mediate the CSE-job satisfaction relation on its own. Implications for the CSE and approach/avoidance literatures are discussed.

  17. The development of malaria diagnostic techniques: a review of the approaches with focus on dielectrophoretic and magnetophoretic methods.

    PubMed

    Kasetsirikul, Surasak; Buranapong, Jirayut; Srituravanich, Werayut; Kaewthamasorn, Morakot; Pimpin, Alongkorn

    2016-07-12

    The large number of deaths caused by malaria each year has increased interest in the development of effective malaria diagnoses. At the early-stage of infection, patients show non-specific symptoms or are asymptomatic, which makes it difficult for clinical diagnosis, especially in non-endemic areas. Alternative diagnostic methods that are timely and effective are required to identify infections, particularly in field settings. This article reviews conventional malaria diagnostic methods together with recently developed techniques for both malaria detection and infected erythrocyte separation. Although many alternative techniques have recently been proposed and studied, dielectrophoretic and magnetophoretic approaches are among the promising new techniques due to their high specificity for malaria parasite-infected red blood cells. The two approaches are discussed in detail, including their principles, types, applications and limitations. In addition, other recently developed techniques, such as cell deformability and morphology, are also overviewed in this article.

  18. Approaches to adaptive digital control focusing on the second order modal descriptions of large, flexible spacecraft dynamics

    NASA Technical Reports Server (NTRS)

    Johnson, C. R., Jr.

    1979-01-01

    The widespread modal analysis of flexible spacecraft and recognition of the poor a priori parameterization possible of the modal descriptions of individual structures have prompted the consideration of adaptive modal control strategies for distributed parameter systems. The current major approaches to computationally efficient adaptive digital control useful in these endeavors are explained in an original, lucid manner using modal second order structure dynamics for algorithm explication. Difficulties in extending these lumped-parameter techniques to distributed-parameter system expansion control are cited.

  19. A multivariate approach for the determination of isoelectric point of human carbonic anhydrase isoforms by capillary isoelectric focusing.

    PubMed

    Lecoeur, Marie; Goossens, Jean-François; Vaccher, Claude; Bonte, Jean-Paul; Foulon, Catherine

    2011-10-01

    Human carbonic anhydrase (hCA) IX and XII are isoenzymes which are highly overexpressed in many cancer types. Recently, it has been shown that hCA IX contributes to the acidification of the tumor environment leading to chemoresistance with basic antitumoral drugs. The development of selective hCA inhibitors constitutes a new therapeutic axis. In order to elucidate the specific interactions between hCA and inhibitors, physico-chemical properties of hCA must be evaluated. This work reports the determination of the isoelectric point (pI) of a series of hCA isoforms by capillary isoelectric focusing. First, the method was optimized with synthetic UV-detectable pI markers using a central composite design. The separation was performed in a fused-silica capillary chemically derivatized with hydroxypropylcellulose and using a glycerol-water medium as the anticonvective gel. Three main factors (ampholyte content, focusing time and mobilization pressure) were optimized in order to obtain the best resolution, detection threshold and precision on the pI determination. Then, the model was validated through the analysis of standard proteins mixture having known pI values, before investigating the pI of hCA isoforms.

  20. The neural correlates of emotional face-processing in adolescent depression: a dimensional approach focusing on anhedonia and illness severity.

    PubMed

    Henderson, Sarah E; Vallejo, Ana I; Ely, Benjamin A; Kang, Guoxin; Krain Roy, Amy; Pine, Daniel S; Stern, Emily R; Gabbay, Vilma

    2014-12-30

    Deficits in emotion processing, a known clinical feature of major depressive disorder (MDD), have been widely investigated using emotional face paradigms and neuroimaging. However, most studies have not accounted for the high inter-subject variability of symptom severity. Similarly, only sparse research has focused on MDD in adolescence, early in the course of the illness. Here we sought to investigate neural responses to emotional faces using both categorical and dimensional analyses with a focus on anhedonia, a core symptom of MDD associated with poor outcomes. Nineteen medication-free depressed adolescents and 18 healthy controls (HC) were scanned during presentation of happy, sad, fearful, and neutral faces. ANCOVAs and regressions assessed group differences and relationships with illness and anhedonia severity, respectively. Findings included a group by valence interaction with depressed adolescents exhibiting decreased activity in the superior temporal gyrus (STG), putamen and premotor cortex. Post-hoc analyses confirmed decreased STG activity in MDD adolescents. Dimensional analyses revealed associations between illness severity and altered responses to negative faces in prefrontal, cingulate, striatal, and limbic regions. However, anhedonia severity was uniquely correlated with responses to happy faces in the prefrontal, cingulate, and insular regions. Our work highlights the need for studying specific symptoms dimensionally in psychiatric research.

  1. A systems approach to evaluating ionizing radiation: six focus areas to improve quality, efficiency, and patient safety.

    PubMed

    Perlin, Jonathan B; Mower, Laura; Bushe, Chris

    2015-01-01

    Ionizing radiation is an essential component of the care process. However, providers and patients may not be fully aware of the risks involved, the level of ionizing radiation delivered with various procedures, or the potential for harm through incidental overexposure or cumulative dose. Recent high-profile incidents demonstrating the devastating short-term consequences of radiation overexposure have drawn attention to these risks, but applicable solutions are lacking. Although various recommendations and guidelines have been proposed, organizational variability challenges providers to identify their own practical solutions. To identify potential failure modes and develop solutions to preserve patient safety within a large, national healthcare system, we assembled a multidisciplinary team to conduct a comprehensive analysis of practices surrounding the delivery of ionizing radiation. Workgroups were developed to analyze existing culture, processes, and technology to identify deficiencies and propose solutions. Six focus areas were identified: competency and certification; equipment; monitoring and auditing; education; clinical pathways; and communication and marketing. This manuscript summarizes this comprehensive, multidisciplinary, and systemic analysis of risk and provides examples to illustrate how these focus areas can be used to improve the use of ionizing radiation. The proposed solutions, once fully implemented, may advance patient safety and care.

  2. Mixed Waste Focus Area mercury contamination product line: An integrated approach to mercury waste treatment and disposal

    SciTech Connect

    Hulet, G.A.; Conley, T.B.; Morris, M.I.

    1998-07-01

    The US Department of Energy (DOE) Mixed Waste Focus Area (MWFA) is tasked with ensuring that solutions are available for the mixed waste treatment problems of the DOE complex. During the MWFA`s initial technical baseline development process, three of the top four technology deficiencies identified were related to the need for amalgamation, stabilization, and separation/removal technologies for the treatment of mercury and mercury-contaminated mixed waste. The focus area grouped mercury-waste-treatment activities into the mercury contamination product line under which development, demonstration, and deployment efforts are coordinated to provide tested technologies to meet the site needs. The Mercury Working Group (HgWG), a selected group of representatives from DOE sites with significant mercury waste inventories, is assisting the MWFA in soliciting, identifying, initiating, and managing efforts to address these areas. Based on the scope and magnitude of the mercury mixed waste problem, as defined by HgWG, solicitations and contract awards have been made to the private sector to demonstrate amalgamation and stabilization processes using actual mixed wastes. Development efforts are currently being funded under the product line that will address DOE`s needs for separation/removal processes. This paper discusses the technology selection process, development activities, and the accomplishments of the MWFA to date through these various activities.

  3. Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms.

    PubMed

    Wadhwa, Pathik D; Buss, Claudia; Entringer, Sonja; Swanson, James M

    2009-09-01

    "Barker's hypothesis" emerged almost 25 years ago from epidemiological studies of birth and death records that revealed a high geographic correlation between rates of infant mortality and certain classes of later adult deaths as well as an association between birthweight and rates of adult death from ischemic heart disease. These observations led to a theory that undernutrition during gestation was an important early origin of adult cardiac and metabolic disorders due to fetal programming that permanently shaped the body's structure, function, and metabolism and contributed to adult disease. This theory stimulated interest in the fetal origins of adult disorders, which expanded and coalesced approximately 5 years ago with the formation of an international society for developmental origins of health and disease (DOHaD). Here we review a few examples of the many emergent themes of the DOHaD approach, including theoretical advances related to predictive adaptive responses of the fetus to a broad range of environmental cues, empirical observations of effects of overnutrition and stress during pregnancy on outcomes in childhood and adulthood, and potential epigenetic mechanisms that may underlie these observations and theory. Next, we discuss the relevance of the DOHaD approach to reproductive medicine. Finally, we consider the next steps that might be taken to apply, evaluate, and extend the DOHaD approach.

  4. Focus stacking: Comparing commercial top-end set-ups with a semi-automatic low budget approach. A possible solution for mass digitization of type specimens.

    PubMed

    Brecko, Jonathan; Mathys, Aurore; Dekoninck, Wouter; Leponce, Maurice; VandenSpiegel, Didier; Semal, Patrick

    2014-01-01

    In this manuscript we present a focus stacking system, composed of commercial photographic equipment. The system is inexpensive compared to high-end commercial focus stacking solutions. We tested this system and compared the results with several different software packages (CombineZP, Auto-Montage, Helicon Focus and Zerene Stacker). We tested our final stacked picture with a picture obtained from two high-end focus stacking solutions: a Leica MZ16A with DFC500 and a Leica Z6APO with DFC290. Zerene Stacker and Helicon Focus both provided satisfactory results. However, Zerene Stacker gives the user more possibilities in terms of control of the software, batch processing and retouching. The outcome of the test on high-end solutions demonstrates that our approach performs better in several ways. The resolution of the tested extended focus pictures is much higher than those from the Leica systems. The flash lighting inside the Ikea closet creates an evenly illuminated picture, without struggling with filters, diffusers, etc. The largest benefit is the price of the set-up which is approximately € 3,000, which is 8 and 10 times less than the LeicaZ6APO and LeicaMZ16A set-up respectively. Overall, this enables institutions to purchase multiple solutions or to start digitising the type collection on a large scale even with a small budget.

  5. Focus stacking: Comparing commercial top-end set-ups with a semi-automatic low budget approach. A possible solution for mass digitization of type specimens

    PubMed Central

    Brecko, Jonathan; Mathys, Aurore; Dekoninck, Wouter; Leponce, Maurice; VandenSpiegel, Didier; Semal, Patrick

    2014-01-01

    Abstract In this manuscript we present a focus stacking system, composed of commercial photographic equipment. The system is inexpensive compared to high-end commercial focus stacking solutions. We tested this system and compared the results with several different software packages (CombineZP, Auto-Montage, Helicon Focus and Zerene Stacker). We tested our final stacked picture with a picture obtained from two high-end focus stacking solutions: a Leica MZ16A with DFC500 and a Leica Z6APO with DFC290. Zerene Stacker and Helicon Focus both provided satisfactory results. However, Zerene Stacker gives the user more possibilities in terms of control of the software, batch processing and retouching. The outcome of the test on high-end solutions demonstrates that our approach performs better in several ways. The resolution of the tested extended focus pictures is much higher than those from the Leica systems. The flash lighting inside the Ikea closet creates an evenly illuminated picture, without struggling with filters, diffusers, etc. The largest benefit is the price of the set-up which is approximately € 3,000, which is 8 and 10 times less than the LeicaZ6APO and LeicaMZ16A set-up respectively. Overall, this enables institutions to purchase multiple solutions or to start digitising the type collection on a large scale even with a small budget. PMID:25589866

  6. Indirect Comprehensive Review Board (ICRB). Final Report

    SciTech Connect

    1996-12-01

    Lockheed Martin Idaho Technologies Company (LMITCO) used a systems engineering approach to take the first step toward defining a requirements baseline for all indirect work at the Idaho National Engineering Laboratory. The intent of this effort was to define the requirements for indirect work, identify the activities necessary to meet the requirements, and to produce defensible cost estimates for the work. The result of this effort is a scrubbed-down, defensible budget for all indirect work in FY 1997. Buying power for each dollar of direct work was increased by $.02. Recommendations are identified for improvements to this process in FY 1998. The purpose of this report is twofold. First is to report the final results of the 1996 ICRB process, and second is to document the process used such that incremental improvements may be made in future years. Objectives, processes, and approaches are described to provide a trail for future boards. Appendices contain copies of board composition, documentation of the process, as well as the actual training materials.

  7. The logic of indirect speech

    PubMed Central

    Pinker, Steven; Nowak, Martin A.; Lee, James J.

    2008-01-01

    When people speak, they often insinuate their intent indirectly rather than stating it as a bald proposition. Examples include sexual come-ons, veiled threats, polite requests, and concealed bribes. We propose a three-part theory of indirect speech, based on the idea that human communication involves a mixture of cooperation and conflict. First, indirect requests allow for plausible deniability, in which a cooperative listener can accept the request, but an uncooperative one cannot react adversarially to it. This intuition is supported by a game-theoretic model that predicts the costs and benefits to a speaker of direct and indirect requests. Second, language has two functions: to convey information and to negotiate the type of relationship holding between speaker and hearer (in particular, dominance, communality, or reciprocity). The emotional costs of a mismatch in the assumed relationship type can create a need for plausible deniability and, thereby, select for indirectness even when there are no tangible costs. Third, people perceive language as a digital medium, which allows a sentence to generate common knowledge, to propagate a message with high fidelity, and to serve as a reference point in coordination games. This feature makes an indirect request qualitatively different from a direct one even when the speaker and listener can infer each other's intentions with high confidence. PMID:18199841

  8. Can ill-structured problems reveal beliefs about medical knowledge and knowing? A focus-group approach

    PubMed Central

    Roex, Ann; Clarebout, Geraldine; Dory, Valerie; Degryse, Jan

    2009-01-01

    Background Epistemological beliefs (EB) are an individual's cognitions about knowledge and knowing. In several non-medical domains, EB have been found to contribute to the way individuals reason when faced with ill-structured problems (i.e. problems with no clear-cut, right or wrong solutions). Such problems are very common in medical practice. Determining whether EB are also influential in reasoning processes with regard to medical issues to which there is no straightforward answer, could have implications for medical education. This study focused on 2 research questions: 1. Can ill-structured problems be used to elicit general practice trainees' and trainers' EB? and 2. What are the views of general practice trainees and trainers about knowledge and how do they justify knowing? Methods 2 focus groups of trainees (n = 18) were convened on 3 occasions during their 1st year of postgraduate GP training. 2 groups of GP trainers (n = 11) met on one occasion. Based on the methodology of the Reflective Judgement Interview (RJI), participants were asked to comment on 11 ill-structured problems. The sessions were audio taped and transcribed and an adapted version of the RJI scoring rules was used to assess the trainees' reasoning about ill-structured problems. Results Participants made a number of statements illustrating their EB and their importance in clinical reasoning. The level of EB varied widely form one meeting to another and depending on the problem addressed. Overall, the EB expressed by trainees did not differ from those of trainers except on a particular ill-structured problem regarding shoulder pain. Conclusion The use of focus groups has entailed some difficulties in the interpretation of the results, but a number of preliminary conclusions can be drawn. Ill-structured medical problems can be used to elicit EB. Most trainees and trainers displayed pre-reflective and quasi-reflective EB. The way trainees and doctors view and justify knowledge are likely to be

  9. Impact of developing technology on indirect liquefaction

    SciTech Connect

    Gray, D.; Lytton, M.; Neuworth, M.; Tomlinson, G.

    1980-11-01

    The status of commercial technology for indirect liquefaction, as exemplified by SASOL facilities in South Africa, is reviewed. The impact of substituting more advanced gasifiers and synthesis systems is then investigated. Slagging BGC/Lurgi, Texaco and Shell-Koppers gasifiers were substituted for the Dry Ash Lurgi units used at SASOL. SASOL SYNTHOL synthesis units were replaced by slurry phase Fischer-Tropsch units employing technology pioneered by Kolbel. The advanced systems were found to have a highly favorable impact on plant efficiency, product distribution and gasoline cost. If all the projected technical improvements can be realized for indirect liquefaction, the yields of refined transportation fuels per ton of coal will approach those anticipated for direct liquefaction processes.

  10. A culturally competent approach to cancer news and education in an inner city community: focus group findings.

    PubMed

    Marks, Jonnie P; Reed, Wornie; Colby, Kay; Dunn, R A; Mosavel, M; Ibrahim, Said A

    2004-01-01

    Ethnic minorities who live in socioeconomically disenfranchised communities suffer disproportionately from many health problems including cancer. In an effort to reduce these disparities, many health-care practitioners and scholars have promoted "culturally competent" health education efforts. One component of culturally competent education is a grounded knowledge base. To obtain knowledge about the cancer-related ideas of members of one African American community, researchers conducted focus groups with public housing residents and used the findings to develop a five-part television news series about breast, prostate, and cervix cancers. We found that participants gathered information from the folk, popular, and professional health sectors and constructed their cancer-related ideas from this information. Furthermore, experiences of racism, sexism, and classism colored their beliefs and behaviors regarding the prevention, detection, and treatment of common cancers. For this community "cancer" represents a giant screen upon which individual fears and societal ethnic, political, and economic tensions are projected.

  11. Bringing a Network-Oriented Approach to Domestic Violence Services: A Focus Group Exploration of Promising Practices.

    PubMed

    Goodman, Lisa A; Banyard, Victoria; Woulfe, Julie; Ash, Sarah; Mattern, Grace

    2016-01-01

    Despite powerful evidence that informal social support contributes to survivors' safety and well-being, mainstream domestic violence (DV) programs have not developed comprehensive models for helping isolated survivors re-engage with these networks. Although many advocates use network-oriented strategies informally, they often do so without resources, funding, or training. This qualitative focus group study explored advocates' use and perceptions of network-oriented strategies. Advocates working in a range of DV programs across one state described the importance of network-oriented work and articulated its five dimensions, including helping survivors build their capacity to form healthy relationships, identify helpful and harmful network members, re-engage with existing networks, develop new relationships, and respond more effectively to network members.

  12. Rangeland and pasture monitoring: an approach to interpretation of high-resolution imagery focused on observer calibration for repeatability.

    PubMed

    Duniway, Michael C; Karl, Jason W; Schrader, Scott; Baquera, Noemi; Herrick, Jeffrey E

    2012-06-01

    Collection of standardized assessment and monitoring data is critically important for supporting policy and management at local to continental scales. Remote sensing techniques, including image interpretation, have shown promise for collecting plant community composition and ground cover data efficiently. More work needs to be done, however, evaluating whether these techniques are sufficiently feasible, cost-effective, and repeatable to be applied in large programs. The goal of this study was to design and test an image-interpretation approach for collecting plant community composition and ground cover data appropriate for local and continental-scale assessment and monitoring of grassland, shrubland, savanna, and pasture ecosystems. We developed a geographic information system image-interpretation tool that uses points classified by experts to calibrate observers, including point-by-point training and quantitative quality control limits. To test this approach, field data and high-resolution imagery (∼3 cm ground sampling distance) were collected concurrently at 54 plots located around the USA. Seven observers with little prior experience used the system to classify 300 points in each plot into ten cover types (grass, shrub, soil, etc.). Good agreement among observers was achieved, with little detectable bias and low variability among observers (coefficient of variation in most plots <0.5). There was a predictable relationship between field and image-interpreter data (R (2) > 0.9), suggesting regression-based adjustments can be used to relate image and field data. This approach could extend the utility of expensive-to-collect field data by allowing it to serve as a validation data source for data collected via image interpretation.

  13. Cervical elastography during pregnancy: a critical review of current approaches with a focus on controversies and limitations.

    PubMed

    Fruscalzo, Arrigo; Mazza, Edoardo; Feltovich, Helen; Schmitz, Ralf

    2016-10-01

    In normal pregnancy, the cervix functions as a protective mechanical barrier that must remain tight and closed. Premature remodeling and consecutive shortening occur in many cases of spontaneous preterm birth. Although the complex underlying physiology of normal and abnormal cervical remodeling is not fully understood, it is clear that cervical softening occurs prior to delivery, and inappropriate timing seems to be associated with preterm delivery. Also, degree of cervical softness is a component of the Bishop score currently used clinically to predict successful induction of labor. Therefore, the assessment of changes in cervical stiffness with ultrasound elastography techniques might be useful in the prediction of preterm delivery or successful induction of labor. Two different approaches for cervical elastography for quantitative determination of the physical properties of the pregnant cervix have been developed: strain elastography and shear wave elastography. Recently, several feasibility studies showed the reliability of these cervical elastography techniques for the prediction of preterm delivery and successful labor induction. In this review, we contrast strain elastography, which determines only relative values of tissue stiffness because the applied transducer pressure is unknown, with shear wave elastography, which provides, in principle at least, a more objective description of tissue softness. While more promising preliminary results involving these approaches to assessing cervical softness have been recently published, current limitations in technical implementation need to be addressed before elastography techniques will become clinically useful. We discuss these limitations and present challenges for future studies and equipment development.

  14. Definition and use of Solution-focused Sustainability Assessment: A novel approach to generate, explore and decide on sustainable solutions for wicked problems.

    PubMed

    Zijp, Michiel C; Posthuma, Leo; Wintersen, Arjen; Devilee, Jeroen; Swartjes, Frank A

    2016-05-01

    This paper introduces Solution-focused Sustainability Assessment (SfSA), provides practical guidance formatted as a versatile process framework, and illustrates its utility for solving a wicked environmental management problem. Society faces complex and increasingly wicked environmental problems for which sustainable solutions are sought. Wicked problems are multi-faceted, and deriving of a management solution requires an approach that is participative, iterative, innovative, and transparent in its definition of sustainability and translation to sustainability metrics. We suggest to add the use of a solution-focused approach. The SfSA framework is collated from elements from risk assessment, risk governance, adaptive management and sustainability assessment frameworks, expanded with the 'solution-focused' paradigm as recently proposed in the context of risk assessment. The main innovation of this approach is the broad exploration of solutions upfront in assessment projects. The case study concerns the sustainable management of slightly contaminated sediments continuously formed in ditches in rural, agricultural areas. This problem is wicked, as disposal of contaminated sediment on adjacent land is potentially hazardous to humans, ecosystems and agricultural products. Non-removal would however reduce drainage capacity followed by increased risks of flooding, while contaminated sediment removal followed by offsite treatment implies high budget costs and soil subsidence. Application of the steps in the SfSA-framework served in solving this problem. Important elements were early exploration of a wide 'solution-space', stakeholder involvement from the onset of the assessment, clear agreements on the risk and sustainability metrics of the problem and on the interpretation and decision procedures, and adaptive management. Application of the key elements of the SfSA approach eventually resulted in adoption of a novel sediment management policy. The stakeholder

  15. Understanding Risk-taking Behavior in Bullies, Victims, and Bully Victims Using Cognitive- and Emotion-Focused Approaches.

    PubMed

    Poon, Kean

    2016-01-01

    Bullying and risky behavior are two common problems among adolescents and can strongly affect a youth's overall functioning when both coexist. Some studies suggest that bullying in adolescence may promote risky behavior as a coping strategy to deal with victimization related stress. Other studies consider bullying as an outcome of high-risk behavior. Despite the association between the two is well-established, no study has examined the risk-taking patterns among bullying groups (i.e., bully, victim, and bully victim). This study attempted to elucidate the potential relationships between bullying and risk-taking by addressing the two models: a cognitive-focused model and an emotion-focused model of risk taking, and to clarify how adolescents' characteristics in risk taking associate with bullying outcomes. Method: 136 Chinese adolescents (Mean Age = 14.5, M = 65, F = 71) were recruited and grouped according to bullying identity: Bully (n = 27), Victim (n = 20), Bully victim (n = 37) and Control (n = 52). Cognitive Appraisal of Risky Events (CARE) questionnaire was used to measure participants' expectancies about the risks, benefits and involvement associated with risky activities. Cambridge Gambling Task (CGT) was administered to capture the emotion-laden process in risk taking. Results: Cognitively, Bully was associated with an overestimation of risk while Victim was associated with an underestimation of risk and overrated benefit. Bully victim exhibited a unique pattern with an overestimation of benefit and risk. All study groups projected higher involvement in risky behavior. Behaviorally, both Bully and Bully victim were associated with high risk modulation whereas Victim was associated with impulsive decision-making. Interestingly, compared with bully, bully victim had significantly higher bullying scores, suggesting a wider range and more frequent bullying activities. In conclusion, Bully maybe a group of adolescents that is vigilant in situational

  16. Understanding Risk-taking Behavior in Bullies, Victims, and Bully Victims Using Cognitive- and Emotion-Focused Approaches

    PubMed Central

    Poon, Kean

    2016-01-01

    Bullying and risky behavior are two common problems among adolescents and can strongly affect a youth’s overall functioning when both coexist. Some studies suggest that bullying in adolescence may promote risky behavior as a coping strategy to deal with victimization related stress. Other studies consider bullying as an outcome of high-risk behavior. Despite the association between the two is well-established, no study has examined the risk-taking patterns among bullying groups (i.e., bully, victim, and bully victim). This study attempted to elucidate the potential relationships between bullying and risk-taking by addressing the two models: a cognitive-focused model and an emotion-focused model of risk taking, and to clarify how adolescents’ characteristics in risk taking associate with bullying outcomes. Method: 136 Chinese adolescents (Mean Age = 14.5, M = 65, F = 71) were recruited and grouped according to bullying identity: Bully (n = 27), Victim (n = 20), Bully victim (n = 37) and Control (n = 52). Cognitive Appraisal of Risky Events (CARE) questionnaire was used to measure participants’ expectancies about the risks, benefits and involvement associated with risky activities. Cambridge Gambling Task (CGT) was administered to capture the emotion-laden process in risk taking. Results: Cognitively, Bully was associated with an overestimation of risk while Victim was associated with an underestimation of risk and overrated benefit. Bully victim exhibited a unique pattern with an overestimation of benefit and risk. All study groups projected higher involvement in risky behavior. Behaviorally, both Bully and Bully victim were associated with high risk modulation whereas Victim was associated with impulsive decision-making. Interestingly, compared with bully, bully victim had significantly higher bullying scores, suggesting a wider range and more frequent bullying activities. In conclusion, Bully maybe a group of adolescents that is vigilant in situational

  17. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

    PubMed Central

    Navarro, Gemma; Morales, Paula; Rodríguez-Cueto, Carmen; Fernández-Ruiz, Javier; Jagerovic, Nadine; Franco, Rafael

    2016-01-01

    Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs), namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2 receptors appear as promising drugs to combat CNS diseases (Parkinson's disease, Huntington's chorea, cerebellar ataxia, amyotrohic lateral sclerosis). Differential localization of CB2 receptors in neural cell types and upregulation in neuroinflammation are keys to understand the therapeutic potential in inter alia diseases that imply progressive neurodegeneration. Medicinal chemistry approaches are now engaged to develop imaging tools to map receptors in the living human brain, to develop more efficacious agonists, and to investigate the possibility to develop allosteric modulators. PMID:27679556

  18. An equilibrium focused approach to calculating the Raman spectrum of the symmetric OH stretch in formic acid dimer

    NASA Astrophysics Data System (ADS)

    Barnes, George L.; Sibert, Edwin L.

    2008-06-01

    The recent reaction surface Hamiltonian model for the double proton tunneling in formic acid dimer of Barnes et al. [G.L. Barnes, S.M. Squires, E.L. Sibert, J. Phys. Chem. B. 112 (2008) 595.] has been applied to the calculation of the symmetric OH stretching Raman spectra. We interpret the full Raman spectra obtained through use of a simplified, single minimum spectrum. Extensive state mixing is found, leading to broad spectral features. Results compare well with the experimental measurements of Bertie et al. [J.E. Bertie, K.H. Michaelian, H.H. Eysel, D. Hager, J. Chem. Phys. 85 (9) (1986) 4779]. We also report improvements upon our previous approach and present ground state and fundamental frequencies as well as tunneling splittings obtained with our new method.

  19. SGLT2 inhibitors – an insulin-independent therapeutic approach for treatment of type 2 diabetes: focus on canagliflozin

    PubMed Central

    Seufert, Jochen

    2015-01-01

    Despite the availability of a great variety of medications, a significant proportion of people with type 2 diabetes mellitus (T2DM) are not able to achieve or maintain adequate glycemic control. Beyond improved glucose control, novel treatments would ideally provide a reduction of cardiovascular risk, with a favorable impact on excess weight, and a low intrinsic hypoglycemia risk, as well as a synergistic mechanism of action for broad combination therapy. With the development of sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic pharmacologic option has recently become available that comes close to meeting these requirements. For the first time, SGLT2 inhibitors offer a therapeutic approach acting directly on the kidneys without requiring insulin secretion or action. Canagliflozin, dapagliflozin, and empagliflozin are the SGLT2 inhibitors approved to date. Taken once a day, these medications can be combined with all other antidiabetic medications including insulin, due to their insulin-independent mechanism of action, with only a minimal risk of hypoglycemia. SGLT2 inhibitors provide additional reductions in body weight and blood pressure due to the therapeutically induced excretion of glucose and sodium through the kidneys. These “concomitant effects” are particularly interesting with regard to the increased cardiovascular risk in T2DM. In many cases, T2DM treatment requires a multidimensional approach where the treatment goals have to be adapted to the individual patient. While there is a consensus on the use of metformin as a first-line drug therapy, various antidiabetics are used for treatment intensification. New mechanisms of action like that of SGLT2 inhibitors such as canagliflozin, which can be used both in early and late stages of diabetes, are a welcome addition to expand the treatment options for patients at every stage of T2DM. The efficacy and tolerability of canagliflozin have been tested in an extensive clinical trial program

  20. SGLT2 inhibitors - an insulin-independent therapeutic approach for treatment of type 2 diabetes: focus on canagliflozin.

    PubMed

    Seufert, Jochen

    2015-01-01

    Despite the availability of a great variety of medications, a significant proportion of people with type 2 diabetes mellitus (T2DM) are not able to achieve or maintain adequate glycemic control. Beyond improved glucose control, novel treatments would ideally provide a reduction of cardiovascular risk, with a favorable impact on excess weight, and a low intrinsic hypoglycemia risk, as well as a synergistic mechanism of action for broad combination therapy. With the development of sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic pharmacologic option has recently become available that comes close to meeting these requirements. For the first time, SGLT2 inhibitors offer a therapeutic approach acting directly on the kidneys without requiring insulin secretion or action. Canagliflozin, dapagliflozin, and empagliflozin are the SGLT2 inhibitors approved to date. Taken once a day, these medications can be combined with all other antidiabetic medications including insulin, due to their insulin-independent mechanism of action, with only a minimal risk of hypoglycemia. SGLT2 inhibitors provide additional reductions in body weight and blood pressure due to the therapeutically induced excretion of glucose and sodium through the kidneys. These "concomitant effects" are particularly interesting with regard to the increased cardiovascular risk in T2DM. In many cases, T2DM treatment requires a multidimensional approach where the treatment goals have to be adapted to the individual patient. While there is a consensus on the use of metformin as a first-line drug therapy, various antidiabetics are used for treatment intensification. New mechanisms of action like that of SGLT2 inhibitors such as canagliflozin, which can be used both in early and late stages of diabetes, are a welcome addition to expand the treatment options for patients at every stage of T2DM. The efficacy and tolerability of canagliflozin have been tested in an extensive clinical trial program

  1. Depth and all-in-focus images obtained by multi-line-scan light-field approach

    NASA Astrophysics Data System (ADS)

    Štolc, Svorad; Huber-Mörk, Reinhold; Holländer, Branislav; Soukup, Daniel

    2014-03-01

    We present a light-field multi-line-scan image acquisition and processing system intended for the 2.5/3-D inspection of fine surface structures, such as small parts, security print, etc. in an industrial environment. The system consists of an area-scan camera, that allows for a small number of sensor lines to be extracted at high frame rates, and a mechanism for transporting the inspected object at a constant speed. During the acquisition, the object is moved orthogonally to the camera's optical axis as well as the orientation of the sensor lines. In each time step, a predefined subset of lines is read out from the sensor and stored. Afterward, by collecting all corresponding lines acquired over time, a 3-D light field is generated, which consists of multiple views of the object observed from different viewing angles while transported w.r.t. the acquisition device. This structure allows for the construction of so-called epipolar plane images (EPIs) and subsequent EPI-based analysis in order to achieve two main goals: (i) the reliable estimation of a dense depth model and (ii) the construction of an all-in-focus intensity image. Beside specifics of our hardware setup, we also provide a detailed description of algorithmic solutions for the mentioned tasks. Two alternative methods for EPI-based analysis are compared based on artificial and real-world data.

  2. Assessing natural direct and indirect effects for a continuous exposure and a dichotomous outcome.

    PubMed

    Wang, Wei; Zhang, Bo

    2016-01-01

    Recent advances in the literature on mediation have extended from traditional linear structural equation modeling approach to causal mediation analysis using potential outcomes framework. Pearl proposed a mediation formula to calculate expected potential outcomes used in the natural direct and indirect effects definition under the key sequential ignorability assumptions. Current methods mainly focused on binary exposure variables, and in this article, this approach is further extended to settings in which continuous exposures may be of interest. Focusing on a dichotomous outcome, we give precise definitions of the natural direct and indirect effects on both the risk difference and odds ratio scales utilizing the empirical joint distribution of the exposure and baseline covariates from the whole sample analysis population. A mediation-formula based approach is proposed to estimate the corresponding causal quantities. Simulation study is conducted to assess the statistical properties of the proposed method and we illustrate our approach by applying it to the Jackson Heart Study to estimate the mediation effects of diabetes on the relation between obesity and chronic kidney disease. Sensitivity analysis is performed to assess the impact of violation of no unmeasured mediator-outcome confounder assumption.

  3. Paediatric drug use with focus on off-label prescriptions in Lombardy and implications for therapeutic approaches.

    PubMed

    Carnovale, Carla; Conti, Valentino; Perrone, Valentina; Antoniazzi, Stefania; Pozzi, Marco; Merlino, Luca; Venegoni, Mauro; Clementi, Emilio; Radice, Sonia

    2013-12-01

    The persistent lack of information on the paediatric use of most medicinal products is a major hindrance towards an optimal treatment of paediatric patients. Several studies have documented the high prevalence of off-label use in paediatric population. No comprehensive studies, however, exist that analyse in full all prescriptions for all dispensed drugs, especially in view of the recent intervention by the European Medicine Agency to tackle this issue. We have assessed the drug prescription pattern in the paediatric outpatient population of Lombardy, which has a reliable record of such prescriptions focusing on off-label drug use. We analysed all dispensed outpatient prescriptions to children aged 0-18 years and the proportion of off-label drug use in 2011, using data from the regional administrative prescriptions database. A total of 4,027,119 prescriptions were dispensed, of which 133,619 (3.3 %) were off-label. The anatomical therapeutic chemical classes most involved in off-label prescriptions were antibiotics for systemic use (33,629), alimentary tract and metabolism (31,739) and respiratory tract (31,458). The highest rate (8 %) of off-label drug prescriptions was observed in the age range 0-1. The study revealed also an inappropriate prescription pattern for fluoroquinolones and drugs targeting the cardiovascular and musculoskeletal systems. We identified inappropriate prescriptions for specific drug classes, highlighting the need of increasing pharmacological studies in the paediatric patients and specific critical drugs/drug classes in which such studies are particularly urgent. Depending on the region, inappropriate paediatric drug prescriptions may affect different drug classes, indicating the need of tailoring specific programmes of information.

  4. Psychosomatic approach is the new medicine tailored for patient personality with a focus on ethics, economy, and quality.

    PubMed

    Fassino, S

    2010-09-01

    Over the last 40 years the proliferation of the biopsychosocial (BPS) model across clinical and theoretical research has shown that psychosocial factors can be shown to be causes, co-factors, or sequelae of many illnesses. Scientific presuppositions about the BPS model have been grounded firmly in psychobiological, psycho-behavioural, sociobiological, and socio-behavioural processes. According to the allostatic load model, stressful factors can be psychological ones or any other factor that is able to modify the stress-response system; these might include genetic factors or life experiences. Personality profiles, in particular, seem to be predictive of responses to different stressors. Stress responses preceding or following illness are clearly related, from a psychobiological point of view, to different personality traits, which themselves correlate to specific defence mechanisms. Neural processes underlying these mechanisms interact with the biological substrate of somatic illnesses. Recent advances in brain imaging with regard to neurobiological and behavioural interactions of empathy and alexithymia support the crucial role of the (psycho) therapeutic relationship across the whole of medical practice. Psychotherapies operate as biological factors on mind, brain, and body; indeed it is necessary to reconsider the doctor-patient relationship as a psychotherapeutic process. The basic methodological triad of observation (outer viewing), introspection (inner viewing), and dialogue (inter viewing) becomes essential in medical practice and in scientific research. Psychoanalytic processes such as transference, resistance, the therapeutic alliance, and attachment have been reconsidered from a neuroscientific perspective and reconceived as moments of meeting of the procedural memory and are therefore considered relevant to the relationship with patients in primary care. Indeed, they are useful to an ethical approach to understanding the meaning of illness, and they also

  5. Indirect Reciprocity; A Field Experiment

    PubMed Central

    van Apeldoorn, Jacobien; Schram, Arthur

    2016-01-01

    Indirect reciprocity involves cooperative acts towards strangers, either in response to their kindness to third parties (downstream) or after receiving kindness from others oneself (upstream). It is considered to be important for the evolution of cooperative behavior amongst humans. Though it has been widely studied theoretically, the empirical evidence of indirect reciprocity has thus far been limited and based solely on behavior in laboratory experiments. We provide evidence from an online environment where members can repeatedly ask and offer services to each other, free of charge. For the purpose of this study we created several new member profiles, which differ only in terms of their serving history. We then sent out a large number of service requests to different members from all over the world. We observe that a service request is more likely to be rewarded for those with a profile history of offering the service (to third parties) in the past. This provides clear evidence of (downstream) indirect reciprocity. We find no support for upstream indirect reciprocity (in this case, rewarding the service request after having previously received the service from third parties), however. Our evidence of downstream indirect reciprocity cannot be attributed to reputational effects concerning one’s trustworthiness as a service user. PMID:27043712

  6. Indirect dark matter searches in gamma and cosmic rays

    NASA Astrophysics Data System (ADS)

    Conrad, Jan; Reimer, Olaf

    2017-03-01

    Dark matter candidates such as weakly interacting massive particles are predicted to annihilate or decay into Standard Model particles, leaving behind distinctive signatures in gamma rays, neutrinos, positrons, antiprotons, or even antinuclei. Indirect dark matter searches, and in particular those based on gamma-ray observations and cosmic-ray measurements, could detect such signatures. Here we review the strengths and limitations of this approach and look into the future of indirect dark matter searches.

  7. Influence of ocean acidification on plankton community structure during a winter-to-summer succession: An imaging approach indicates that copepods can benefit from elevated CO2 via indirect food web effects.

    PubMed

    Taucher, Jan; Haunost, Mathias; Boxhammer, Tim; Bach, Lennart T; Algueró-Muñiz, María; Riebesell, Ulf

    2017-01-01

    Plankton communities play a key role in the marine food web and are expected to be highly sensitive to ongoing environmental change. Oceanic uptake of anthropogenic carbon dioxide (CO2) causes pronounced shifts in marine carbonate chemistry and a decrease in seawater pH. These changes-summarized by the term ocean acidification (OA)-can significantly affect the physiology of planktonic organisms. However, studies on the response of entire plankton communities to OA, which also include indirect effects via food-web interactions, are still relatively rare. Thus, it is presently unclear how OA could affect the functioning of entire ecosystems and biogeochemical element cycles. In this study, we report from a long-term in situ mesocosm experiment, where we investigated the response of natural plankton communities in temperate waters (Gullmarfjord, Sweden) to elevated CO2 concentrations and OA as expected for the end of the century (~760 μatm pCO2). Based on a plankton-imaging approach, we examined size structure, community composition and food web characteristics of the whole plankton assemblage, ranging from picoplankton to mesozooplankton, during an entire winter-to-summer succession. The plankton imaging system revealed pronounced temporal changes in the size structure of the copepod community over the course of the plankton bloom. The observed shift towards smaller individuals resulted in an overall decrease of copepod biomass by 25%, despite increasing numerical abundances. Furthermore, we observed distinct effects of elevated CO2 on biomass and size structure of the entire plankton community. Notably, the biomass of copepods, dominated by Pseudocalanus acuspes, displayed a tendency towards elevated biomass by up to 30-40% under simulated ocean acidification. This effect was significant for certain copepod size classes and was most likely driven by CO2-stimulated responses of primary producers and a complex interplay of trophic interactions that allowed this CO2

  8. Influence of ocean acidification on plankton community structure during a winter-to-summer succession: An imaging approach indicates that copepods can benefit from elevated CO2 via indirect food web effects

    PubMed Central

    Taucher, Jan; Haunost, Mathias; Boxhammer, Tim; Bach, Lennart T.; Algueró-Muñiz, María; Riebesell, Ulf

    2017-01-01

    Plankton communities play a key role in the marine food web and are expected to be highly sensitive to ongoing environmental change. Oceanic uptake of anthropogenic carbon dioxide (CO2) causes pronounced shifts in marine carbonate chemistry and a decrease in seawater pH. These changes–summarized by the term ocean acidification (OA)–can significantly affect the physiology of planktonic organisms. However, studies on the response of entire plankton communities to OA, which also include indirect effects via food-web interactions, are still relatively rare. Thus, it is presently unclear how OA could affect the functioning of entire ecosystems and biogeochemical element cycles. In this study, we report from a long-term in situ mesocosm experiment, where we investigated the response of natural plankton communities in temperate waters (Gullmarfjord, Sweden) to elevated CO2 concentrations and OA as expected for the end of the century (~760 μatm pCO2). Based on a plankton-imaging approach, we examined size structure, community composition and food web characteristics of the whole plankton assemblage, ranging from picoplankton to mesozooplankton, during an entire winter-to-summer succession. The plankton imaging system revealed pronounced temporal changes in the size structure of the copepod community over the course of the plankton bloom. The observed shift towards smaller individuals resulted in an overall decrease of copepod biomass by 25%, despite increasing numerical abundances. Furthermore, we observed distinct effects of elevated CO2 on biomass and size structure of the entire plankton community. Notably, the biomass of copepods, dominated by Pseudocalanus acuspes, displayed a tendency towards elevated biomass by up to 30–40% under simulated ocean acidification. This effect was significant for certain copepod size classes and was most likely driven by CO2-stimulated responses of primary producers and a complex interplay of trophic interactions that allowed this

  9. Evidence-based evolution of an integrated nutrition-focused agriculture approach to address the underlying determinants of stunting.

    PubMed

    Haselow, Nancy J; Stormer, Ame; Pries, Alissa

    2016-05-01

    Despite progress in reducing hunger and malnutrition since the 1990s, many still suffer from undernutrition and food insecurity, particularly women and young children, resulting in preterm birth, low birthweight and stunting, among other conditions. Helen Keller International (HKI) has addressed malnutrition and household food insecurity through implementation of an Enhanced Homestead Food Production (EHFP) programme that increases year-round availability and intake of diverse micronutrient-rich foods and promotes optimal nutrition and hygiene practices among poor households. This paper reviews the evolution and impact of HKI's EHFP programme and identifies core components of the model that address the underlying determinants of stunting. To date, evaluations of EHFP have shown impact on food production, consumption by women and children and household food security. Sale of surplus produce has increased household income, and the use of a transformative gender approach has empowered women. EHFP has also realized nutrition improvements in many project sites. Results from a randomized control trial (RCT) in Baitadi district, Nepal showed a significant improvement in a range of practices known to impact child growth, although no impact on stunting. Additional non-RCT evaluations in Kailali district of Nepal, demonstrated a 10.5% reduction in stunting and in the Chittagong Hill Tracts in Bangladesh, revealed an 18% decrease in stunting. Based on evidence, the EHFP has evolved into an integrated package that includes agriculture, nutrition, water/hygiene/sanitation, linkages to health care, women's empowerment, income generation and advocacy. Closing the stunting gap requires long-term exposure to targeted multi-sectoral solutions and rigorous evaluation to optimize impact.

  10. Implementing Child-focused Activity Meter Utilization into the Elementary School Classroom Setting Using a Collaborative Community-based Approach

    PubMed Central

    Lynch, BA; Jones, A; Biggs, BK; Kaufman, T; Cristiani, V; Kumar, S; Quigg, S; Maxson, J; Swenson, L; Jacobson, N

    2016-01-01

    Introduction The prevalence of pediatric obesity has increased over the past 3 decades and is a pressing public health program. New technology advancements that can encourage more physical in children are needed. The Zamzee program is an activity meter linked to a motivational website designed for children 8–14 years of age. The objective of the study was to use a collaborative approach between a medical center, the private sector and local school staff to assess the feasibility of using the Zamzee Program in the school-based setting to improve physical activity levels in children. Methods This was a pilot 8-week observational study offered to all children in one fifth grade classroom. Body mass index (BMI), the amount of physical activity by 3-day recall survey, and satisfaction with usability of the Zamzee Program were measured pre- and post-study. Results Out of 11 children who enrolled in the study, 7 completed all study activities. In those who completed the study, the median (interquartile range) total activity time by survey increased by 17 (1042) minutes and the BMI percentile change was 0 (8). Both children and their caregivers found the Zamzee Activity Meter (6/7) and website (6/7) “very easy” or “easy” to use. Conclusion The Zamzee Program was found to be usable but did not significantly improve physical activity levels or BMI. Collaborative obesity intervention projects involving medical centers, the private sector and local schools are feasible but the effectiveness needs to be evaluated in larger-scale studies. PMID:27042382

  11. The Use of Total Human Bone Marrow Fraction in a Direct Three-Dimensional Expansion Approach for Bone Tissue Engineering Applications: Focus on Angiogenesis and Osteogenesis

    PubMed Central

    Oliveira, Hugo; Catros, Sylvain; Siadous, Robin; Derkaoui, Sidi-Mohammed; Bareille, Reine; Letourneur, Didier; Amédée, Joëlle

    2015-01-01

    Current approaches in bone tissue engineering have shown limited success, mostly owing to insufficient vascularization of the construct. A common approach consists of co-culture of endothelial cells and osteoblastic cells. This strategy uses cells from different sources and differentiation states, thus increasing the complexity upstream of a clinical application. The source of reparative cells is paramount for the success of bone tissue engineering applications. In this context, stem cells obtained from human bone marrow hold much promise. Here, we analyzed the potential of human whole bone marrow cells directly expanded in a three-dimensional (3D) polymer matrix and focused on the further characterization of this heterogeneous population and on their ability to promote angiogenesis and osteogenesis, both in vitro and in vivo, in a subcutaneous model. Cellular aggregates were formed within 24 h and over the 12-day culture period expressed endothelial and bone-specific markers and a specific junctional protein. Ectopic implantation of the tissue-engineered constructs revealed osteoid tissue and vessel formation both at the periphery and within the implant. This work sheds light on the potential clinical use of human whole bone marrow for bone regeneration strategies, focusing on a simplified approach to develop a direct 3D culture without two-dimensional isolation or expansion. PMID:25333855

  12. A Novel Approach to Realizing Routine HIV Screening and Enhancing Linkage to Care in the United States: Protocol of the FOCUS Program and Early Results

    PubMed Central

    Sullivan, Patrick S; Rothman, Richard E; Brown, Emily H; Fitzpatrick, Lisa K; Wood, Angela F; Hernandez, Paloma I; Nunn, Amy S; Serota, Martin L; Moreno-Walton, Lisa

    2014-01-01

    Background The United States health care system remains far from implementing the Centers for Disease Control and Prevention's recommendation of routine human immunodeficiency virus (HIV) screening as part of health care for adults. Although consensus for the importance of screening has grown, innovations in implementing routine screening are still lacking. HIV on the Frontlines of Communities in the United States (FOCUS) was launched in 2010 to provide an environment for testing innovative approaches to routine HIV screening and linkage to care. Objective The strategy of the FOCUS program was to develop models that maximize the use of information systems, fully integrate HIV screening into clinical practice, transform basic perceptions about routine HIV screening, and capitalize on emerging technologies in health care settings and laboratories. Methods In 10 of the most highly impacted cities, the FOCUS program supports 153 partnerships to increase routine HIV screening in clinical and community settings. Results From program launch in 2010 through October 2013, the partnerships have resulted in a total of 799,573 HIV tests and 0.68% (5425/799,573) tested positive. Conclusions The FOCUS program is a unique model that will identify best practices for HIV screening and linkage to care. PMID:25093431

  13. Indirect methods in nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Bertulani, C. A.; Shubhchintak; Mukhamedzhanov, A.; Kadyrov, A. S.; Kruppa, A.; Pang, D. Y.

    2016-04-01

    We discuss recent developments in indirect methods used in nuclear astrophysics to determine the capture cross sections and subsequent rates of various stellar burning processes, when it is difficult to perform the corresponding direct measurements. We discuss in brief, the basic concepts of Asymptotic Normalization Coefficients, the Trojan Horse Method, the Coulomb Dissociation Method, (d,p), and charge-exchange reactions.

  14. An analytical approach to estimating aberrations in curved multilayer optics for hard x-rays: 2. Interpretation and application to focusing experiments.

    PubMed

    Morawe, Ch; Guigay, J-P; Mocella, V; Ferrero, C

    2008-09-29

    Aberration effects are studied in parabolic and elliptic multilayer mirrors for hard x-rays, basing on a simple analytical approach. The interpretation of the underlying equations provides insight into fundamental limitations of the focusing properties of curved multilayers. Using realistic values for the multilayer parameters the potential impact on the broadening of the focal spot is evaluated. Within the limits of this model, systematic contributions to the spot size can be described. The work is complemented by a comparison with experimental results obtained with a W/B(4)C curved multilayer mirror.

  15. 19 CFR 10.879 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.879 Section 10.879 Customs... of Origin § 10.879 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  16. 19 CFR 10.816 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.816 Section 10.816 Customs... Rules of Origin § 10.816 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  17. 19 CFR 10.816 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.816 Section 10.816 Customs... Rules of Origin § 10.816 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  18. 19 CFR 10.879 - Indirect materials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Indirect materials. 10.879 Section 10.879 Customs... of Origin § 10.879 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  19. 19 CFR 10.816 - Indirect materials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Indirect materials. 10.816 Section 10.816 Customs... Rules of Origin § 10.816 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  20. 19 CFR 10.776 - Indirect materials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Indirect materials. 10.776 Section 10.776 Customs... Rules of Origin § 10.776 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  1. 19 CFR 10.879 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.879 Section 10.879 Customs... of Origin § 10.879 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  2. 19 CFR 10.776 - Indirect materials.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect materials. 10.776 Section 10.776 Customs... Rules of Origin § 10.776 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  3. 19 CFR 10.776 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.776 Section 10.776 Customs... Rules of Origin § 10.776 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  4. 19 CFR 10.776 - Indirect materials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Indirect materials. 10.776 Section 10.776 Customs... Rules of Origin § 10.776 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  5. 19 CFR 10.816 - Indirect materials.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect materials. 10.816 Section 10.816 Customs... Rules of Origin § 10.816 Indirect materials. Indirect materials are to be disregarded in determining..., except that the cost of such indirect materials may be included in meeting the value-content...

  6. Quantifying nonadditive selection caused by indirect ecological effects.

    PubMed

    TerHorst, Casey P; Lau, Jennifer A; Cooper, Idelle A; Keller, Kane R; La Rosa, Raffica J; Royer, Anne M; Schultheis, Elizabeth H; Suwa, Tomomi; Conner, Jeffrey K

    2015-09-01

    In natural biological communities, species interact with many other species. Multiple species interactions can lead to indirect ecological effects that have important fitness consequences and can cause nonadditive patterns of natural selection. Given that indirect ecological effects are common in nature, nonadditive selection may also be quite common. As a result, quantifying nonadditive selection resulting from indirect ecological effects may be critical for understanding adaptation in natural communities composed of many interacting species. We describe how to quantify the relative strength of nonadditive selection resulting from indirect ecological effects compared to the strength of pairwise selection. We develop a clear method for testing for nonadditive selection caused by indirect ecological effects and consider how it might affect adaptation in multispecies communities. We use two case studies to illustrate how our method can be applied to empirical data sets. Our results suggest that nonadditive selection caused by indirect ecological effects may be common in nature. Our hope is that trait-based approaches, combined with multifactorial experiments, will result in more estimates of nonadditive selection that reveal the relative importance of indirect ecological effects for evolution in a community context.

  7. Parent-only vs. parent-child (family-focused) approaches for weight loss in obese and overweight children: a systematic review and meta-analysis.

    PubMed

    Jull, A; Chen, R

    2013-09-01

    Families are recommended as the agents of change for weight loss in overweight and obese children; family approaches are more effective than those that focus on the child alone. However, interventions that focus on parents alone have not been summarized. The objective of this review was to assess the effectiveness of interventions that compared a parent-only (PO) condition with a parent-child (PC) condition. Four trials using a similar between-group background approaches to overweight and obese children's weight loss met the inclusion criteria, but only one trial reported sufficient data for meta-analysis. Further information was obtained from authors. Meta-analysis showed no significant difference in z-BMI from baseline to end of treatment between the conditions (three trials) or to end of follow up (two trials). The trials were at risk of bias and no single trial was at lower risk of bias than others. There is an absence of high quality evidence regarding the effect of parent-only interventions for weight loss in children compared to parent-child interventions, but current evidence suggests the need for further investigation.

  8. Indirect Aggression, Bullying and Female Teen Victimization: A Literature Review

    ERIC Educational Resources Information Center

    Catanzaro, Mary F.

    2011-01-01

    This article assesses the literature in relation to youth bullying in the United Kingdom, Scandinavia and North America, focusing in particular on female aggression as it is expressed in adolescent peer relationships. It addresses the escalating problems of indirect aggression, especially those involving social networking interchanges such as…

  9. Bioechnology of indirect liquefaction. Final report

    SciTech Connect

    Datta, R.; Jain, M.K.; Worden, R.M.; Grethlein, A.J.; Soni, B.; Zeikus, J.G.; Grethlein, H.

    1990-05-07

    The project on biotechnology of indirect liquefaction was focused on conversion of coal derived synthesis gas to liquid fuels using a two-stage, acidogenic and solventogenic, anaerobic bioconversion process. The acidogenic fermentation used a novel and versatile organism, Butyribacterium methylotrophicum, which was fully capable of using CO as the sole carbon and energy source for organic acid production. In extended batch CO fermentations the organism was induced to produce butyrate at the expense of acetate at low pH values. Long-term, steady-state operation was achieved during continuous CO fermentations with this organism, and at low pH values (a pH of 6.0 or less) minor amounts of butanol and ethanol were produced. During continuous, steady-state fermentations of CO with cell recycle, concentrations of mixed acids and alcohols were achieved (approximately 12 g/l and 2 g/l, respectively) which are high enough for efficient conversion in stage two of the indirect liquefaction process. The metabolic pathway to produce 4-carbon alcohols from CO was a novel discovery and is believed to be unique to our CO strain of B. methylotrophicum. In the solventogenic phase, the parent strain ATCC 4259 of Clostridium acetobutylicum was mutagenized using nitrosoguanidine and ethyl methane sulfonate. The E-604 mutant strain of Clostridium acetobutylicum showed improved characteristics as compared to parent strain ATCC 4259 in batch fermentation of carbohydrates.

  10. The Native Telehealth Outreach and Technical Assistance Program: a community-based approach to the development of multimedia-focused health care information.

    PubMed

    Dick, Rhonda Wiegman; Manson, Spero M; Hansen, Amy L; Huggins, Annie; Trullinger, Lori

    2007-01-01

    The development and dissemination of culturally relevant health care information has traditionally taken a "top-down" approach. Governmental funding agencies and research institutions have too often dictated the importance and focus of health-related research and information dissemination. In addition, the digital divide has affected rural communities in such a way that their members often do not possess the knowledge or experience necessary to use technological resources. And, even when they do, their skills may be limited, adequate only for implementing applications and programs designed by others who live and work outside of these communities. This need became the driving force in the creation of the Native Telehealth Outreach and Technical Assistance Program. The goal of the program is to equip Native community members, at both the lay and professional levels, with the means to use technology to address tribal health care needs. The transfer of relevant technical knowledge and skills enables participants to develop projects which enhance the community-wide dissemination of health care information. Nine community health advocates and professionals participated in the initial cohort. Eight of the participants successfully developed multimedia-based projects including Web sites, interactive CD-ROMs, and video focusing on a variety of health concerns. At the conclusion of the 18-month program period, projects were disseminated throughout rural communities. The NTOTAP staff continues to evaluate the use of these projects and their benefits within the rural communities.

  11. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with...

  12. Ion focusing

    DOEpatents

    Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

    2017-01-17

    The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

  13. Ion focusing

    SciTech Connect

    Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

    2015-11-10

    The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

  14. An integrated approach to the evaluation of a metabolomic fingerprint for a phytocomplex. Focus on artichoke [Cynara cardunculus subsp. scolymus] leaf.

    PubMed

    Fodaroni, Giada; Burico, Michela; Gaetano, Anna; Maidecchi, Anna; Pagiotti, Rita; Mattoli, Luisa; Traldi, Pietro; Ragazzi, Eugenio

    2014-04-01

    The availability of reliable herbal formulations is essential in order to assure the maximal activity and to limit unwanted side-effects. The correct concentration of declared components of herbal products is a matter of health legislation and regulation, but is still a topic under debate in the field of quality control assessment. In the present work specific constituents of artichoke leaf extracts, considered as a test herbal product, were measured by standard spectrophotometric and HPLC methods (for quantitative determination of some components only), and results were correlated with the ESI-MS (showing the full metabolomic fingerprint). Phytocomplex stability over time was also investigated in batches submitted to different storage conditions. The results indicated excellent agreement between the two approaches in the measurement of total caffeoylquinic acids and chlorogenic acid contents, but the metabolomic ESI-MS method approach provides a more complete evaluation and monitoring of the composition of a herbal product, without focusing only on a single/few compound measurements. Therefore, the ESI-MS method can be proposed for the evaluation of the quality of complex matrices, such as those in a phytocomplex. Another aspect lies in the possibility to obtain a broad-spectrum stability control of herbal formulations, requiring minimal sample pre-processing procedures.

  15. A Radiological Survey Approach to Use Prior to Decommissioning: Results from a Technology Scanning and Assessment Project Focused on the Chornobyl NPP

    SciTech Connect

    Milchikov, A.; Hund, G.; Davidko, M.

    1999-10-20

    The primary objectives of this project are to learn how to plan and execute the Technology Scanning and Assessment (TSA) approach by conducting a project and to be able to provide the approach as a capability to the Chernobyl Nuclear Power Plant (ChNPP) and potentially elsewhere. A secondary objective is to learn specifics about decommissioning and in particular about radiological surveying to be performed prior to decommissioning to help ChNPP decision makers. TSA is a multi-faceted capability that monitors and analyzes scientific, technical, regulatory, and business factors and trends for decision makers and company leaders. It is a management tool where information is systematically gathered, analyzed, and used in business planning and decision making. It helps managers by organizing the flow of critical information and provides managers with information they can act upon. The focus of this TSA project is on radiological surveying with the target being ChNPP's Unit 1. This reactor was stopped on November 30, 1996. At this time, Ukraine failed to have a regulatory basis to provide guidelines for nuclear site decommissioning. This situation has not changed as of today. A number of documents have been prepared to become a basis for a combined study of the ChNPP Unit 1 from the engineering and radiological perspectives. The results of such a study are expected to be used when a detailed decommissioning plan is created.

  16. Physiologic and weight-focused treatment strategies for managing type 2 diabetes mellitus: the metformin, glucagon-like peptide-1 receptor agonist, and insulin (MGI) approach.

    PubMed

    Nadeau, Daniel A

    2013-05-01

    The prevalence of type 2 diabetes mellitus (T2DM) is rising in association with an increase in obesity rates. Current treatment options for patients with T2DM include lifestyle modifications and numerous antidiabetic medications. Despite the availability of effective and well-tolerated treatments, many patients do not achieve recommended glycemic targets. Lack of efficacy is complicated by the wide range of available agents and little specificity in treatment guidelines, thus challenging clinicians to understand the relative benefits and risks of individual options for each patient. In this article, lifestyle intervention strategies and current antidiabetic agents are evaluated for their efficacy, safety, and weight-loss potential. Because of the heterogeneous and progressive nature of T2DM, physicians should advocate approaches that emphasize weight management, limit the risk of hypoglycemia and adverse events, and focus on the core pathophysiologic defects in patients with T2DM. A healthy, plant-based diet that is low in saturated fat and refined carbohydrates but high in whole grains, vegetables, legumes, and fruits, coupled with resistance and aerobic exercise regimens, are recommended for patients with T2DM. When necessary, drug intervention, described in this article as the MGI (metformin, glucagon-like peptide-1 receptor agonist, and insulin) approach, should begin with metformin and progress to the early addition of glucagon-like peptide-1 receptor agonists because of their weight loss potential and ability to target multiple pathophysiologic defects in patients with T2DM. For most patients, treatments that induce weight gain and hypoglycemia should be avoided. Long-acting insulin should be initiated if glycemic control is not achieved with metformin and glucagon-like peptide-1 receptor agonist combination therapy, focusing on long-acting insulin analogs that induce the least weight gain and have the lowest hypoglycemic risk. Ultimately, a patient

  17. Application of a multivariate approach for analyte focusing by micelle collapse-micellar electrokinetic chromatography for analyzing sunscreen agents in cosmetics.

    PubMed

    Lin, Yi-Hui; Lu, Chi-Yu; Jiang, Shiuh-Jen; Hsiao, Wen-Yao; Cheng, Hui-Ling; Chen, Yen-Ling

    2015-10-01

    The operating parameters that affect the performance of the online preconcentration technique "analyte focusing by micelle collapse-MEKC (AFMC-MEKC)" were examined using a multivariate approach involving experimental design to determine the sunscreen agents in cosmetics. Compared to the single-variable approach, the advantage of the multivariate approach was that many factors could be investigated simultaneously to obtain the best separation condition. A fractional factorial design was used to identify the fewest significant factors in the central composite design (cCD). The cCD was adopted for evaluating the location of the minimum or maximum response in this study. The influences of the experimental variables on the response were investigated by applying a chromatographic exponential function. The optimized condition and the relationship between the experimental variables were acquired using the JMP software. The ANOVA analysis indicated that the Tris pH value, SDS concentration, and ethanol percentage influenced the separation quality and significantly contributed to the model. The optimized condition of the running buffer was 10 mM Tris buffer (pH 9.5) containing 60 mM SDS, 7 mM γ-CD, and 20% v/v ethanol. The sample was prepared in 100 mM Tris buffer (pH 9.0) containing 7.5 mM SDS and 20% v/v ethanol. The SDS concentration in the sample matrix was slightly greater than the CMC value that makes the micelle be easily collapsed and the analytes be accumulated in the capillary. In addition, sunscreen agents in cosmetics after 1000-fold dilution were successfully determined by AFMC-MEKC.

  18. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Indirect costs. 2903.4 Section 2903.4 Agriculture... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with...

  19. 7 CFR 3430.54 - Indirect costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Indirect costs. 3430.54 Section 3430.54 Agriculture... Post-Award and Closeout § 3430.54 Indirect costs. Indirect cost rates for grants and cooperative agreements shall be determined in accordance with the applicable assistance regulations and cost...

  20. 48 CFR 31.203 - Indirect costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Indirect costs. 31.203... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.203 Indirect costs. (a) For contracts subject to full CAS coverage, allocation of indirect costs shall be based...

  1. 48 CFR 31.203 - Indirect costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Indirect costs. 31.203... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.203 Indirect costs. (a) For contracts subject to full CAS coverage, allocation of indirect costs shall be based...

  2. 46 CFR 154.1720 - Indirect refrigeration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Indirect refrigeration. 154.1720 Section 154.1720... § 154.1720 Indirect refrigeration. A refrigeration system that is used to cool acetaldehyde, ethylene oxide, or methyl bromide, must be an indirect refrigeration system that does not use vapor compression....

  3. 46 CFR 154.1720 - Indirect refrigeration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Indirect refrigeration. 154.1720 Section 154.1720... § 154.1720 Indirect refrigeration. A refrigeration system that is used to cool acetaldehyde, ethylene oxide, or methyl bromide, must be an indirect refrigeration system that does not use vapor compression....

  4. 46 CFR 154.1720 - Indirect refrigeration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Indirect refrigeration. 154.1720 Section 154.1720... § 154.1720 Indirect refrigeration. A refrigeration system that is used to cool acetaldehyde, ethylene oxide, or methyl bromide, must be an indirect refrigeration system that does not use vapor compression....

  5. 46 CFR 154.1720 - Indirect refrigeration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Indirect refrigeration. 154.1720 Section 154.1720... § 154.1720 Indirect refrigeration. A refrigeration system that is used to cool acetaldehyde, ethylene oxide, or methyl bromide, must be an indirect refrigeration system that does not use vapor compression....

  6. 46 CFR 154.1720 - Indirect refrigeration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Indirect refrigeration. 154.1720 Section 154.1720... § 154.1720 Indirect refrigeration. A refrigeration system that is used to cool acetaldehyde, ethylene oxide, or methyl bromide, must be an indirect refrigeration system that does not use vapor compression....

  7. 19 CFR 10.460 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.460 Section 10.460 Customs... of Origin § 10.460 Indirect materials. An indirect material, as defined in § 10.402(o), will be considered to be an originating material without regard to where it is produced. Example. Chilean Producer...

  8. 19 CFR 10.603 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.603 Section 10.603 Customs... States Free Trade Agreement Rules of Origin § 10.603 Indirect materials. An indirect material, as defined in § 10.582(m) of this subpart, will be considered to be an originating material without regard...

  9. 19 CFR 10.460 - Indirect materials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Indirect materials. 10.460 Section 10.460 Customs... of Origin § 10.460 Indirect materials. An indirect material, as defined in § 10.402(o), will be considered to be an originating material without regard to where it is produced. Example. Chilean Producer...

  10. 19 CFR 10.460 - Indirect materials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Indirect materials. 10.460 Section 10.460 Customs... of Origin § 10.460 Indirect materials. An indirect material, as defined in § 10.402(o), will be considered to be an originating material without regard to where it is produced. Example. Chilean Producer...

  11. 19 CFR 10.2024 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.2024 Section 10.2024... Agreement Rules of Origin § 10.2024 Indirect materials. An indirect material, as defined in § 10.2013(i), will be considered to be an originating material without regard to where it is produced....

  12. 19 CFR 10.541 - Indirect materials.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect materials. 10.541 Section 10.541 Customs... Rules of Origin § 10.541 Indirect materials. An indirect material, as defined in § 10.502(j) of this subpart, will be considered to be an originating material without regard to where it is produced, and...

  13. 19 CFR 10.541 - Indirect materials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Indirect materials. 10.541 Section 10.541 Customs... Rules of Origin § 10.541 Indirect materials. An indirect material, as defined in § 10.502(j) of this subpart, will be considered to be an originating material without regard to where it is produced, and...

  14. 19 CFR 10.541 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.541 Section 10.541 Customs... Rules of Origin § 10.541 Indirect materials. An indirect material, as defined in § 10.502(j) of this subpart, will be considered to be an originating material without regard to where it is produced, and...

  15. 19 CFR 10.541 - Indirect materials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Indirect materials. 10.541 Section 10.541 Customs... Rules of Origin § 10.541 Indirect materials. An indirect material, as defined in § 10.502(j) of this subpart, will be considered to be an originating material without regard to where it is produced, and...

  16. 19 CFR 10.1024 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.1024 Section 10.1024... Agreement Rules of Origin § 10.1024 Indirect materials. An indirect material, as defined in § 10.1002(n) of.... Korean Producer A produces good C using non-originating material B. Producer A imports...

  17. 19 CFR 10.603 - Indirect materials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Indirect materials. 10.603 Section 10.603 Customs... States Free Trade Agreement Rules of Origin § 10.603 Indirect materials. An indirect material, as defined in § 10.582(m) of this subpart, will be considered to be an originating material without regard...

  18. 19 CFR 10.924 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.924 Section 10.924 Customs... Rules of Origin § 10.924 Indirect materials. An indirect material, as defined in § 10.902(m) of this subpart, will be considered to be an originating material without regard to where it is produced....

  19. 19 CFR 10.3024 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.3024 Section 10.3024... Promotion Agreement Rules of Origin § 10.3024 Indirect materials. An indirect material, as defined in § 10.3013(h), will be considered to be an originating material without regard to where it is...

  20. 19 CFR 10.603 - Indirect materials.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect materials. 10.603 Section 10.603 Customs... States Free Trade Agreement Rules of Origin § 10.603 Indirect materials. An indirect material, as defined in § 10.582(m) of this subpart, will be considered to be an originating material without regard...

  1. 19 CFR 10.603 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.603 Section 10.603 Customs... States Free Trade Agreement Rules of Origin § 10.603 Indirect materials. An indirect material, as defined in § 10.582(m) of this subpart, will be considered to be an originating material without regard...

  2. 19 CFR 10.460 - Indirect materials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Indirect materials. 10.460 Section 10.460 Customs... of Origin § 10.460 Indirect materials. An indirect material, as defined in § 10.402(o), will be considered to be an originating material without regard to where it is produced. Example. Chilean Producer...

  3. 19 CFR 10.603 - Indirect materials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Indirect materials. 10.603 Section 10.603 Customs... States Free Trade Agreement Rules of Origin § 10.603 Indirect materials. An indirect material, as defined in § 10.582(m) of this subpart, will be considered to be an originating material without regard...

  4. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with the... funds. Grantees electing this alternative will not be allowed to charge, as direct costs, indirect...

  5. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with the... funds. Grantees electing this alternative will not be allowed to charge, as direct costs, indirect...

  6. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with the... funds. Grantees electing this alternative will not be allowed to charge, as direct costs, indirect...

  7. Indirect reciprocity with trinary reputations.

    PubMed

    Tanabe, Shoma; Suzuki, Hideyuki; Masuda, Naoki

    2013-01-21

    Indirect reciprocity is a reputation-based mechanism for cooperation in social dilemma situations when individuals do not repeatedly meet. The conditions under which cooperation based on indirect reciprocity occurs have been examined in great details. Most previous theoretical analysis assumed for mathematical tractability that an individual possesses a binary reputation value, i.e., good or bad, which depends on their past actions and other factors. However, in real situations, reputations of individuals may be multiple valued. Another puzzling discrepancy between the theory and experiments is the status of the so-called image scoring, in which cooperation and defection are judged to be good and bad, respectively, independent of other factors. Such an assessment rule is found in behavioral experiments, whereas it is known to be unstable in theory. In the present study, we fill both gaps by analyzing a trinary reputation model. By an exhaustive search, we identify all the cooperative and stable equilibria composed of a homogeneous population or a heterogeneous population containing two types of players. Some results derived for the trinary reputation model are direct extensions of those for the binary model. However, we find that the trinary model allows cooperation under image scoring under some mild conditions.

  8. Indirect costs of rheumatoid arthritis

    PubMed Central

    Raciborski, Filip; Kwiatkowska, Brygida

    2015-01-01

    It is estimated that in Poland about 400,000 persons in general suffer from inflammatory joint diseases, including rheumatoid arthritis (RA). Epidemiological surveys documenting the frequency and disturbance of musculoskeletal disorders in the Polish population are few in number. Most of the estimations are based on epidemiological data from other countries (prevalence of 0.5–1%). According to the data of the National Health Fund in Poland 135,000–157,000 persons in total are treated because of rheumatoid arthritis per year [ICD10 (International Statistical Classification of Diseases and Related Health Problems): M05, M06]. In the case of this group of diseases indirect costs significantly outweigh the direct costs. Indirect costs increase together with activity level of the disease. The cost analysis of productivity loss of RA patients indicates that sickness absenteeism and informal care are the most burdensome. At the national level it amounts in total from 1.2 billion to 2.8 billion PLN per year, depending on the method of analysis. These costs could be significantly reduced through early diagnosis and introduction of effective treatment. PMID:27407258

  9. Indirect Teaching and Assessment: Are They Mutually Exclusive?

    ERIC Educational Resources Information Center

    Pope, Carol A.

    1990-01-01

    Principals may wonder how to evaluate teachers using student-centered, indirect teaching strategies with an assessment instrument geared to reward a more teacher-centered approach. This article offers some suggestions concerning the instructional cycle, classroom observation techniques, postobservation conferences, and the formal writeup. (MLH)

  10. The indirect electrochemical refining of lunar ores

    NASA Technical Reports Server (NTRS)

    Semkow, Krystyna W.; Sammells, Anthony F.

    1987-01-01

    Recent work performed on an electrolytic cell is reported which addresses the implicit limitations in various approaches to refining lunar ores. The cell uses an oxygen vacancy conducting stabilized zirconia solid electrolyte to effect separation between a molten salt catholyte compartment where alkali metals are deposited, and an oxygen-evolving anode of composition La(0.89)Sr(0.1)MnO3. The cell configuration is shown and discussed along with a polarization curve and a steady-state current-voltage curve. In a practical cell, cathodically deposited liquid lithium would be continuously removed from the electrolytic cell and used as a valuable reducing agent for ore refining under lunar conditions. Oxygen would be indirectly electrochemically extracted from lunar ores for breathing purposes.

  11. Global Search Capabilities of Indirect Methods for Impulsive Transfers

    NASA Astrophysics Data System (ADS)

    Shen, Hong-Xin; Casalino, Lorenzo; Luo, Ya-Zhong

    2015-09-01

    An optimization method which combines an indirect method with homotopic approach is proposed and applied to impulsive trajectories. Minimum-fuel, multiple-impulse solutions, with either fixed or open time are obtained. The homotopic approach at hand is relatively straightforward to implement and does not require an initial guess of adjoints, unlike previous adjoints estimation methods. A multiple-revolution Lambert solver is used to find multiple starting solutions for the homotopic procedure; this approach can guarantee to obtain multiple local solutions without relying on the user's intuition, thus efficiently exploring the solution space to find the global optimum. The indirect/homotopic approach proves to be quite effective and efficient in finding optimal solutions, and outperforms the joint use of evolutionary algorithms and deterministic methods in the test cases.

  12. Neutron-capture Cross Sections from Indirect Measurements

    SciTech Connect

    Escher, J E; Burke, J T; Dietrich, F S; Ressler, J J; Scielzo, N D; Thompson, I J

    2011-10-18

    Cross sections for compound-nuclear reactions play an important role in models of astrophysical environments and simulations of the nuclear fuel cycle. Providing reliable cross section data remains a formidable task, and direct measurements have to be complemented by theoretical predictions and indirect methods. The surrogate nuclear reactions method provides an indirect approach for determining cross sections for reactions on unstable isotopes, which are difficult or impossible to measure otherwise. Current implementations of the method provide useful cross sections for (n,f) reactions, but need to be improved upon for applications to capture reactions.

  13. Separate spheres and indirect benefits

    PubMed Central

    Brock, Dan W

    2003-01-01

    On any plausible account of the basis for health care resource prioritization, the benefits and costs of different alternative resource uses are relevant considerations in the prioritization process. Consequentialists hold that the maximization of benefits with available resources is the only relevant consideration. Non-consequentialists do not reject the relevance of consequences of benefits and costs, but insist that other considerations, and in particular the distribution of benefits and costs, are morally important as well. Whatever one's particular account of morally justified standards for the prioritization of different health interventions, we must be able to measure those interventions' benefits and costs. There are many theoretical and practical difficulties in that measurement, such as how to weigh extending life against improving health and quality of life as well as how different quality of life improvements should be valued, but they are not my concern here. This paper addresses two related issues in assessing benefits and costs for health resource prioritization. First, should benefits be restricted only to health benefits, or include as well other non health benefits such as economic benefits to employers from reducing the lost work time due to illness of their employees? I shall call this the Separate Spheres problem. Second, should only the direct benefits, such as extending life or reducing disability, and direct costs, such as costs of medical personnel and supplies, of health interventions be counted, or should other indirect benefits and costs be counted as well? I shall call this the Indirect Benefits problem. These two issues can have great importance for a ranking of different health interventions by either a cost/benefit or cost effectiveness analysis (CEA) standard. PMID:12773217

  14. Indirect Global Warming Potentials of Halons Using Atmospheric Models

    NASA Astrophysics Data System (ADS)

    Youn, D.; Patten, K. O.; Wuebbles, D. J.

    2007-05-01

    Emission of bromochlorofluorocarbons, or Halons, results in stratospheric ozone depletion. This leads to cooling of the climate system in the opposite direction to direct warming contribution of the Halons as greenhouse gases. This cooling is a key indirect effect of Halons on radiative forcing or climate. The Global Warming Potential (GWP) is a relative index used to compare the climate impact of an emitted greenhouse gas, relative to an equal amount of carbon dioxide. Until now, indirect GWPs have been calculated based on the concept of Equivalent Effective Stratospheric Chlorine (EESC), which oversimplifies the complex processes in the atmosphere. As a step towards obtaining indirect GWPs through a more robust approach, 2-D and 3-D global chemical transport models (CTM) were used as the computational tool to derive more realistic ozone changes caused by pulse perturbation of Halons at the surface. Indirect GWPs of Halon-1211 and -1301 for a 100-year time horizon were explicitly calculated based on the University of Illinois at Urbana-Champaign (UIUC) 2-D global CTM and radiative transport model (RTM) and the 3-D CTM, MOZART-3.1. The 2-D and 3-D model simulations show acceptable temporal variations in the atmosphere as well as derived lifetimes and direct GWP values of the Halons. The 2-D model-based indirect GWPs for a 100-year horizon are -16,294 for Halon-1211 and -33,648 for Halon-1301. 3-D indirect GWP for Halon-1211 is -18,216. The indirect GWPs for Halon-1211 presented here are much smaller than previous published results using the previous simplified appraoch.

  15. Infant feeding counselling in Uganda in a changing environment with focus on the general population and HIV-positive mothers - a mixed method approach

    PubMed Central

    2010-01-01

    Background Health workers' counselling practices are essential to improve infant feeding practices. This paper will assess how infant feeding counselling was done and experienced by counsellors and mothers in Eastern Uganda in the context of previous guidelines. This has implications for implementation of the new infant feeding guidelines from 2009. Methods This paper combines qualitative and quantitative data from Mbale District in Eastern Uganda. Data was collected from 2003 to 2005 in a mixed methods approach. This includes: key-informant interviews among eighteen health workers in the public hospital, health clinics and non-governmental organisations working with people living with HIV, fifteen focus group discussions in the general population and among clients from an HIV clinic, two cross-sectional surveys including 727 mothers from the general population and 235 HIV-positive mothers. Results The counselling sessions were often improvised. Health workers frequently had pragmatic approaches to infant feeding as many clients struggled with poverty, stigma and non-disclosure of HIV. The feasibility of the infant feeding recommendations was perceived as challenging among health workers, both for HIV-positive mothers and in the general population. Group counselling with large groups was common in the public health service. Some extra infant feeding teaching capacities were mobilised for care-takers of undernourished children. A tendency to simplify messages giving one-sided information was seen. Different health workers presented contradicting simplified perspectives in some cases. Outdated training was a common concern with many health workers not being given courses or seminars on infant feeding since professional graduation. Other problems were minimal staffing, lack of resources, and programs being started and subsequently stopped abruptly. Many of the HIV-counsellors in the non-governmental organisations got extended training in counselling which seemed to be

  16. Supporting Risk Assessment: Accounting for Indirect Risk to Ecosystem Components.

    PubMed

    Murray, Cathryn Clarke; Mach, Megan E; Martone, Rebecca G; Singh, Gerald G; O, Miriam; Chan, Kai M A

    2016-01-01

    The multi-scalar complexity of social-ecological systems makes it challenging to quantify impacts from human activities on ecosystems, inspiring risk-based approaches to assessments of potential effects of human activities on valued ecosystem components. Risk assessments do not commonly include the risk from indirect effects as mediated via habitat and prey. In this case study from British Columbia, Canada, we illustrate how such "indirect risks" can be incorporated into risk assessments for seventeen ecosystem components. We ask whether (i) the addition of indirect risk changes the at-risk ranking of the seventeen ecosystem components and if (ii) risk scores correlate with trophic prey and habitat linkages in the food web. Even with conservative assumptions about the transfer of impacts or risks from prey species and habitats, the addition of indirect risks in the cumulative risk score changes the ranking of priorities for management. In particular, resident orca, Steller sea lion, and Pacific herring all increase in relative risk, more closely aligning these species with their "at-risk status" designations. Risk assessments are not a replacement for impact assessments, but-by considering the potential for indirect risks as we demonstrate here-they offer a crucial complementary perspective for the management of ecosystems and the organisms within.

  17. Supporting Risk Assessment: Accounting for Indirect Risk to Ecosystem Components

    PubMed Central

    Mach, Megan E.; Martone, Rebecca G.; Singh, Gerald G.; O, Miriam; Chan, Kai M. A.

    2016-01-01

    The multi-scalar complexity of social-ecological systems makes it challenging to quantify impacts from human activities on ecosystems, inspiring risk-based approaches to assessments of potential effects of human activities on valued ecosystem components. Risk assessments do not commonly include the risk from indirect effects as mediated via habitat and prey. In this case study from British Columbia, Canada, we illustrate how such “indirect risks” can be incorporated into risk assessments for seventeen ecosystem components. We ask whether (i) the addition of indirect risk changes the at-risk ranking of the seventeen ecosystem components and if (ii) risk scores correlate with trophic prey and habitat linkages in the food web. Even with conservative assumptions about the transfer of impacts or risks from prey species and habitats, the addition of indirect risks in the cumulative risk score changes the ranking of priorities for management. In particular, resident orca, Steller sea lion, and Pacific herring all increase in relative risk, more closely aligning these species with their “at-risk status” designations. Risk assessments are not a replacement for impact assessments, but—by considering the potential for indirect risks as we demonstrate here—they offer a crucial complementary perspective for the management of ecosystems and the organisms within. PMID:27632287

  18. Electrophoretic Focusing

    NASA Technical Reports Server (NTRS)

    Snyder, Robert S.

    2001-01-01

    Electrophoretic focusing is a new method of continuous flow electrophoresis that introduces precision flow control to achieve high resolution separations. The electric field is applied perpendicular to an incoming sample lamina and buffer but also perpendicular to the broad faces of the thin rectangular chamber. A uniform fluid cross-flow then enters and exits the separation chamber through the same broad faces which are porous. A balance is achieved by adjusting either the electric field or the cross-flow so the desired sample fraction with its specific migration velocity encounters an opposing flow of the same velocity. Applying an electric field transverse to the incoming sample lamina and opposing this field with a carefully configured buffer flow, a sample constituent can be selected and focused into a narrow stream for subsequent analysis. Monotonically changing either electric field or buffer cross-flow will yield a scan of all constituents of the sample. Stopping the scan increases the collection time for minor constituents to improve their analysis. Using the high voltage gradients and/or cross-flow to rapidly deflect extraneous sample through the porous screens and into either of the side (purge) chambers, the selected sample is focused in the center plane of the separation chamber and collected without contact or interaction with the separation chamber walls. Results will be presented on the separation of a range of materials including dyes, proteins, and monodisperse polystyrene latexes. Sources of sample dispersion inherent in other electrokinetic techniques will be shown to be negligible for a variety of sample concentrations, buffer properties and operating conditions.

  19. Indirect-Cost Management Guide: Navigating the Sea of Overhead

    DTIC Science & Technology

    2001-10-01

    for each cost pool) are developed by industry in a very disciplined manner as an in- tegral part of the corporate- business planning process. This...sary for managing indirect costs. The business planning process represents top management decisions that focus on how the corporation plans to be...phases of business planning . The business planning process results in the prepa- ration of a mathematical model of the total cor- poration; therefore

  20. Indirect discrimination and breast screening.

    PubMed

    Botha, J L; Manku-Scott, T K; Moledina, F; Williams, A

    1993-01-01

    Uptake of screening services in inner-city communities has been low, particularly in older age groups, lower social classes, and ethnic minorities. In Leicester City, where up to 25% of the population belong to ethnic minorities, this may have important implications for breast screening. We randomly sampled 701 inner-city women aged 45 to 64 years, stratified by neighborhood and by women's "likely home language." Trained interviewers succeeded in interviewing 79% of those eligible, and we report here a preliminary analysis of 413 respondents. Knowledge of breast cancer and screening varied markedly and significantly by actual language: 60.4% of English-speaking and 12.5% of non-English-speaking women correctly answered 10 or more questions (of 14) about breast cancer and screening (chi 2(1) = 89.884; P = .000). Despite that, 80% or more women stated their intention to attend for screening and assessment if necessary, irrespective of neighborhood, language, age, or social class. We suggest that the difference in knowledge between language groups arose from indirect discrimination in the way in which health-related information is disseminated in British society. However, after providing appropriate screening information, we report similarly high intended acceptance rates in the two language groups.

  1. Indirect cytotoxicity evaluation of pseudowollastonite.

    PubMed

    Dufrane, D; Delloye, C; McKay, I J; De Aza, P N; De Aza, S; Schneider, Y J; Anseau, M

    2003-01-01

    This study aimed to evaluate the cytotoxicity of substances leached by pseudowollastonite (CaSiO(3)). It has been previously shown that calcium (Ca(2+)) and silicate (SiO(3)(-)) ions are released from pseudowollastonite into biological solutions. Both of these ions are known to influence the biological metabolism of osteoblastic cells essential in the mineralization process and bone-bonding mechanism. The indirect toxicity evaluation was performed by extraction method, according to International Standard Organization (ISO). Pseudowollastonite pellets obtained by solid-state reaction were incubated, in culture medium, during 24, 48, 72 or 168 h at different concentrations (5, 10, 15, 50, 100, 200 mg/ml). The cytotoxicity of each extract in presence of human osteoblastic cell line (SaOS-2) was quantitatively assessed by measuring the viability (succinate dehydrogenase activity, MTT), the membrane integrity (the uptake of the neutral red by viable cells, NR) as well as the cell necrosis by measuring the lactate dehydrogenase (LDH) released in the culture medium. No significant alteration of membrane integrity or cell suffering was detectable. However, increased cell metabolism was observed for cells exposed to pseudowollastonite extract with longest extraction time (168 h). In conclusion, mineral elements leached by pseudowollastonite do not significantly affect the metabolism of osteoblastic cells.

  2. Direct and indirect measurements on electrocaloric effect: Recent developments and perspectives

    NASA Astrophysics Data System (ADS)

    Liu, Yang; Scott, James F.; Dkhil, Brahim

    2016-09-01

    It has been ten years since the discovery of the giant electrocaloric effect in ferroelectric materials showed that it is possible to employ this effect for substantial cooling applications. This last decade has been marked by increasing research interest, especially in characterizing and measuring the electrocaloric effect using both the so-called indirect and direct approaches. In this context, a comprehensive summary and careful reexamination of these approaches are very timely and of great importance to justify the assumptions used in different measurement techniques. This review is therefore dedicated to cover recent important and rapid advances from both the indirect and direct measurements and provides critical insights relevant for quantifying the electrocaloric effect. It involves electrocaloric materials from normal ferroelectrics, antiferroelectrics, and relaxors, and it fundamentally focuses on how the electrocaloric entropy changes in response to electric field in these typical electrocalorics. The article addresses recent developments, especially during the past three years, such as technical selection of proper polarization-electric field loops, negative electrocaloric effect in antiferroelectrics and relaxors, the controversial debate on the indirect method in relaxors, the important role of field dependence of specific heat, kinetic factors, and so on. Moreover, this review also is concerned with extracting reliable data by direct measurements. Four typical techniques and devices used recently, such as thermocouples, differential scanning calorimeters, specifically designed calorimeters, and scanning thermal microscopy, are briefly reviewed, while infrared cameras are emphasized. We hope that our review will not only provide a useful background to understand fundamentally the electrocaloric effect and what one really measures but also may act as a practical guide to exploit and develop electrocalorics towards the design of suitable devices.

  3. Decontamination & decommissioning focus area

    SciTech Connect

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  4. Indirect Self-Destructiveness and Emotional Intelligence.

    PubMed

    Tsirigotis, Konstantinos

    2016-06-01

    While emotional intelligence may have a favourable influence on the life and psychological and social functioning of the individual, indirect self-destructiveness exerts a rather negative influence. The aim of this study has been to explore possible relations between indirect self-destructiveness and emotional intelligence. A population of 260 individuals (130 females and 130 males) aged 20-30 (mean age of 24.5) was studied by using the Polish version of the chronic self-destructiveness scale and INTE, i.e., the Polish version of the assessing emotions scale. Indirect self-destructiveness has significant correlations with all variables of INTE (overall score, factor I, factor II), and these correlations are negative. The intensity of indirect self-destructiveness differentiates significantly the height of the emotional intelligence and vice versa: the height of the emotional intelligence differentiates significantly the intensity of indirect self-destructiveness. Indirect self-destructiveness has negative correlations with emotional intelligence as well as its components: the ability to recognize emotions and the ability to utilize emotions. The height of emotional intelligence differentiates the intensity of indirect self-destructiveness, and vice versa: the intensity of indirect self-destructiveness differentiates the height of emotional intelligence. It seems advisable to use emotional intelligence in the prophylactic and therapeutic work with persons with various types of disorders, especially with the syndrome of indirect self-destructiveness.

  5. Two stage indirect evaporative cooling system

    SciTech Connect

    Bourne, Richard C.; Lee, Brian E.; Callaway, Duncan

    2005-08-23

    A two stage indirect evaporative cooler that moves air from a blower mounted above the unit, vertically downward into dry air passages in an indirect stage and turns the air flow horizontally before leaving the indirect stage. After leaving the dry passages, a major air portion travels into the direct stage and the remainder of the air is induced by a pressure drop in the direct stage to turn 180.degree. and returns horizontally through wet passages in the indirect stage and out of the unit as exhaust air.

  6. Plutonium focus area

    SciTech Connect

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  7. Comparison of indirect cost multipliers for vehicle manufacturing

    SciTech Connect

    Vyas, A.; Santini, D.; Cuenca, R.

    2000-05-16

    In the process of manufacturing and selling vehicles, a manufacturer incurs certain costs. Among these costs are those incurred directly as a part of manufacturing operations and those incurred indirectly in the processes of manufacturing and selling. The indirect costs may be production-related, such as R and D and engineering; business-related, such as corporate staff salaries and pensions; or retail-sales-related, such as dealer support and marketing. These indirect costs are recovered by allocating them to each vehicle. Under a stable, high-volume production process, the allocation of these indirect costs can be approximated as multipliers (or factors) applied to the direct cost of manufacturing. A manufacturer usually allocates indirect costs to finished vehicles according to a corporation-specific pricing strategy. Because the volumes of sales and production vary widely by model within a corporation, the internal corporate percent allocation of various accounting categories (such as profit or corporate overheat) can vary widely among individual models. Approaches also vary across corporations. For these purposes, an average value is constructed, by means of a generic representative method, for vehicle models produced at high volume. To accomplish this, staff at Argonne National Laboratory's (ANL's) Center for Transportation Research analyzed the conventional vehicle cost structure and developed indirect cost multipliers for passenger vehicles. This memorandum summarizes the results of an effort to compare and put on a common basis the cost multipliers used in ANL's electric and hybrid electric vehicle cost estimation procedures with those resulting from two other methodologies. One of the two compared methodologies is derived from a 1996 presentation by Dr. Chris Borroni-Bird of Chrysler Corporation, the other is by Energy and Environmental Analysis, Inc. (EEA), as described in a 1995 report by the Office of Technology Assessment (OTA), Congress of the United

  8. Resource construction and evaluation for indirect opinion mining of drug reviews.

    PubMed

    Noferesti, Samira; Shamsfard, Mehrnoush

    2015-01-01

    Opinion mining is a well-known problem in natural language processing that has attracted increasing attention in recent years. Existing approaches are mainly limited to the identification of direct opinions and are mostly dedicated to explicit opinions. However, in some domains such as medical, the opinions about an entity are not usually expressed by opinion words directly, but they are expressed indirectly by describing the effect of that entity on other ones. Therefore, ignoring indirect opinions can lead to the loss of valuable information and noticeable decline in overall accuracy of opinion mining systems. In this paper, we first introduce the task of indirect opinion mining. Then, we present a novel approach to construct a knowledge base of indirect opinions, called OpinionKB, which aims to be a resource for automatically classifying people's opinions about drugs. Using our approach, we have extracted 896 quadruples of indirect opinions at a precision of 88.08 percent. Furthermore, experiments on drug reviews demonstrate that our approach can achieve 85.25 percent precision in polarity detection task, and outperforms the state-of-the-art opinion mining methods. We also build a corpus of indirect opinions about drugs, which can be used as a basis for supervised indirect opinion mining. The proposed approach for corpus construction achieves the precision of 88.42 percent.

  9. Path To Ignition: US Indirect Target Physics (LIRPP Vol. 12)

    NASA Astrophysics Data System (ADS)

    Cray, M.; Campbell, E. M.

    2016-10-01

    The United States ICF Program has been pursuing an aggressive research program in preparation for an ignition demonstration on the National Ignition Facility. Los Alamos and Livermore laboratories have collaborated on resolving indirect drive target physics issues on the Nova laser at Livermore National Laboratory. This combined with detailed modeling of laser heated indirectly driven targets likely to achieve ignition, has provided the basis for planning for the NIF. A detailed understanding of target physics, laser performance, and target fabrication is required for developing robust ignition targets. We have developed large-scale computational models to simulate complex physics which occurs in an indirectly driven target. For ignition, detailed understanding of hohlraum and implosion physics is required in order to control competing processes at the few percent level. From crucial experiments performed by Los Alamos and Livermore on the Nova laser, a comprehensive indirect drive database has been assembled. Time integrated and time dependent measurements of radiation drive and symmetry coupled with a detailed set of plasma instability measurements have confirmed our ability to predict hohlraum energetics. Implosion physics campaigns are focused on underdstanding detailed capsule hydrodynamics and instability growth. Target fabrication technology is also an active area of research at Los Alamos, Livermore, and General Atomics for NIF. NIF targets require developing technology in cryogenics and manufacturing in such areas as beryllium shell manufacture. Descriptions of our NIF target designs, experimental results, and fabrication technology supporting NIF target performance predictions will be given.

  10. 29 CFR 452.119 - Indirect elections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Indirect elections. 452.119 Section 452.119 Labor... STANDARDS GENERAL STATEMENT CONCERNING THE ELECTION PROVISIONS OF THE LABOR-MANAGEMENT REPORTING AND DISCLOSURE ACT OF 1959 Election Procedures; Rights of Members § 452.119 Indirect elections. National...

  11. Sliding indirect hernia containing both ovaries.

    PubMed

    Fowler, Carol L

    2005-09-01

    Although sliding indirect inguinal hernias containing the ipsilateral ovary and fallopian tube are not uncommon in infant girls, sliding hernias containing both ovaries are rare. This report describes a large indirect inguinal hernia in a 1-year-old infant girl that contained the left uterine fundus, left bladder ear, as well as both ovaries and fallopian tubes.

  12. 77 FR 41899 - Indirect Food Additives: Polymers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 177 Indirect Food Additives: Polymers AGENCY... CFR part 177 is amended as follows: PART 177--INDIRECT FOOD ADDITIVES: POLYMERS 0 1. The...

  13. 27 CFR 6.26 - Indirect interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Indirect interest. 6.26 Section 6.26 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Interest in Retail License § 6.26 Indirect interest. Industry member interest in...

  14. 27 CFR 6.32 - Indirect interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Indirect interest. 6.32 Section 6.32 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Interest in Retail Property § 6.32 Indirect interest. Industry member interest in...

  15. Effectiveness of structured patient-clinician communication with a solution focused approach (DIALOG+) in community treatment of patients with psychosis – a cluster randomised controlled trial

    PubMed Central

    2013-01-01

    Background Large numbers of patients with psychosis have regular meetings with key clinicians in the community. There is little evidence on how these meetings should be conducted to be therapeutically effective. DIALOG, a computer mediated procedure, was shown to improve outcomes in a European multi-centre trial. DIALOG structures the patient-clinician communication and makes it patient-centred, but does not guide clinicians as to how to respond to patients’ concerns. DIALOG has been further developed into DIALOG+, which uses advanced software and, additionally, provides a four step approach - based on a solution focused model - for addressing patients’ concerns. We designed a cluster randomised controlled trial to test the effectiveness of DIALOG+ in improving treatment outcomes of patients with psychosis in the community. Methods/design Key workers are recruited from community mental health teams in East London and randomly allocated to either the intervention or control group. Out of their case loads, we identify patients with schizophrenia (F 20–29) and a moderate or lower level of subjective quality of life (MANSA score <5), who are treated according to the allocation of their key workers. Key workers in the intervention group are trained in using DIALOG+ and use it with each patient over a six-month period. Control patients rate their satisfaction with life and treatment on a tablet to control for the effect of regular ratings and the use of modern technology. We are recruiting up to 42 key workers to reach a total sample size of 180 patients. Clinical and social outcomes including costs are assessed after 3, 6 and 12 months. Primary outcome is subjective quality-of-life at 6 months. Discussion The trial aims to evaluate the effectiveness of a novel intervention (DIALOG+) which uses modern technology to support routine patient-clinician meetings in community care, makes the communication patient centred and guides patients and clinicians to address

  16. Sensitivity of Aerosol Indirect Effects to Representation of Autoconversion

    NASA Astrophysics Data System (ADS)

    Hsieh, W.; Adams, P. J.; Seinfeld, J. H.; Nenes, A.

    2008-12-01

    We study the sensitivity of aerosol indirect effects to the approach used for computing autoconversion of cloudwater into rain. The NASA GISS II-prime GCM, with online simulation of aerosol and cloud droplet number (using the activation parameterization of Fountoukis and Nenes, 2005) are used for simulating the sensitivity of climate and aerosol indirect effects to autoconversion schemes. Simulations are done using the autoconversion parameterizations of Liu and Daum (2004) [P6], Khairoutdinov and Kogan, (2000) [KK], Manton and Cotton, (1977) [MC] and direct integration of the kinetic collection equation (KCE) using a gravitational (GRV) collection kernel with and without enhancement from turbulence (TUR). Given the uncertainty associated with the importance of turbulence on droplet collection, we carry out simulations using two published kernels with substantially different sensitivity to turbulence. Simulations show that increased aerosol associated with anthropogenic activity increase annual mean LWP from changes in autoconversion; strongest effects are seen in highly polluted areas. The spatial distribution of indirect forcing strongly correlates with simulated changes in LWP between pre-industrial and present day simulations; strongest cooling is seen in SE Asia, Western Europe, and eastern US. The combined first and second indirect effect is quite sensitive to the autoconversion scheme used, being -1.30 W m-2 using P6, - 2.05 W m-2 for KK, and, -1.53 W m-2 MC. Using KCE, a smaller indirect effect is simulated, being -0.89 W m- 2 when gravitational collection is only considered, and, equal to -1.03 W m-2 when also enhanced by turbulence. The spatial and temporal distribution of cloud droplet number, effective radius and liquid water content and their sensitivity to the approach used for autoconversion is also assessed.

  17. Surrogate Nuclear Reactions - An Indirect Method for Determining Reaction Cross Sections

    SciTech Connect

    Escher, J; Ahle, L; Bernstein, L; Burke, J; Church, J A; Dietrich, F; Forssen, C; Hoffman, R; Gueorguiev, V

    2005-03-23

    An indirect method for determining cross sections of reactions proceeding through a compound nucleus is presented. Some applications of the Surrogate nuclear reaction approach are considered and challenges that need to be addressed are outlined.

  18. Focus on First Graders.

    ERIC Educational Resources Information Center

    Schwartz, Shari S.

    The result of a collaboration between the El Paso, Texas, school district and community agencies, the Focus on First Graders program provides early intervention and prevention using a comprehensive approach to providing a variety of services at the school to at-risk first graders from low income families. Teachers and parents were surveyed to…

  19. [Focus: Family Communication].

    ERIC Educational Resources Information Center

    Barnes, Richard E., Ed.

    1977-01-01

    This issue of the "Journal of the Wisconsin Communication Association" focuses on family communication and contains the following articles: "Marital Typologies: An Alternative Approach to the Study of Communication in Enduring Relations" by Mary Anne Fitzpatrick, "Intimate Communication and the Family" by Marilyn D. LaCourt, and "A Study in…

  20. Evaluating aerosol indirect effect through marine stratocumulus clouds

    SciTech Connect

    Kogan, Z.N.; Kogan, Y.L.; Lilly, D.K.

    1996-04-01

    During the last decade much attention has been focused on anthropogenic aerosols and their radiative influence on the global climate. Charlson et al. and Penner et al. have demonstrated that tropospheric aerosols and particularly anthropogenic sulfate aerosols may significantly contribute to the radiative forcing exerting a cooling influence on climate (-1 to -2 W/m{sup 2}) which is comparable in magnitude to greenhouse forcing, but opposite in sign. Aerosol particles affect the earth`s radiative budget either directly by scattering and absorption of solar radiation by themselves or indirectly by altering the cloud radiative properties through changes in cloud microstructure. Marine stratocumulus cloud layers and their possible cooling influence on the atmosphere as a result of pollution are of special interest because of their high reflectivity, durability, and large global cover. We present an estimate of thet aerosol indirect effect, or, forcing due to anthropogenic sulfate aerosols.

  1. Capillary electrophoresis with indirect amperometric detection.

    PubMed

    Olefirowicz, T M; Ewing, A G

    1990-01-19

    The use of indirect amperometric detection with capillary electrophoresis is demonstrated. The system consists of a porous glass coupler which allows amperometric detection at a carbon fiber electrode placed in the end of the capillary. 3,4-Dihydroxybenzylamine is added to the buffer system as a continuously eluting electrophore. Indirect amperometric detection in 9-mumol I.D. capillaries provides detection limits as low as 380 attomole for the amino acid arginine. Finally, both direct and indirect amperometric detection can be accomplished simultaneously.

  2. Precision protection through indirect correlations

    SciTech Connect

    Jin, Yao

    2016-04-15

    The dynamics of the quantum Fisher information of the parameters of the initial atomic state is studied, in the framework of open quantum systems, for a pair of static two-level atoms coupled to a bath of fluctuating vacuum scalar fields. Our results show that the correlations between the two atoms as well as the precision limit in quantum metrology are determined by the separation between the two atoms. Remarkably, when the separation between the two atoms approaches zero, the quantum Fisher information, thus the precision limit of the estimation of the parameters of the initial atomic state will be survived from the vacuum fluctuations after long time evolution.

  3. Indirect suppression of photosynthesis on individual leaves by arthropod herbivory

    PubMed Central

    Nabity, Paul D.; Zavala, Jorge A.; DeLucia, Evan H.

    2009-01-01

    Background Herbivory reduces leaf area, disrupts the function of leaves, and ultimately alters yield and productivity. Herbivore damage to foliage typically is assessed in the field by measuring the amount of leaf tissue removed and disrupted. This approach assumes the remaining tissues are unaltered, and plant photosynthesis and water balance function normally. However, recent application of thermal and fluorescent imaging technologies revealed that alterations to photosynthesis and transpiration propagate into remaining undamaged leaf tissue. Scope and Conclusions This review briefly examines the indirect effects of herbivory on photosynthesis, measured by gas exchange or chlorophyll fluorescence, and identifies four mechanisms contributing to the indirect suppression of photosynthesis in remaining leaf tissues: severed vasculature, altered sink demand, defence-induced autotoxicity, and defence-induced down-regulation of photosynthesis. We review the chlorophyll fluorescence and thermal imaging techniques used to gather layers of spatial data and discuss methods for compiling these layers to achieve greater insight into mechanisms contributing to the indirect suppression of photosynthesis. We also elaborate on a few herbivore-induced gene-regulating mechanisms which modulate photosynthesis and discuss the difficult nature of measuring spatial heterogeneity when combining fluorescence imaging and gas exchange technology. Although few studies have characterized herbivore-induced indirect effects on photosynthesis at the leaf level, an emerging literature suggests that the loss of photosynthetic capacity following herbivory may be greater than direct loss of photosynthetic tissues. Depending on the damage guild, ignoring the indirect suppression of photosynthesis by arthropods and other organisms may lead to an underestimate of their physiological and ecological impacts. PMID:18660492

  4. Indirect punishment and generosity toward strangers.

    PubMed

    Ule, Aljaz; Schram, Arthur; Riedl, Arno; Cason, Timothy N

    2009-12-18

    Many people incur costs to reward strangers who have been kind to others. Theoretical and experimental evidence suggests that such "indirect rewarding" sustains cooperation between unrelated humans. Its emergence is surprising, because rewarders incur costs but receive no immediate benefits. It can prevail in the long run only if rewarders earn higher payoffs than "defectors" who ignore strangers' kindness. We provide experimental evidence regarding the payoffs received by individuals who employ these and other strategies, such as "indirect punishment," by imposing costs on unkind strangers. We find that if unkind strangers cannot be punished, defection earns most. If they can be punished, however, then indirect rewarding earns most. Indirect punishment plays this important role, even if it gives a low payoff and is rarely implemented.

  5. Indirect Lighting--a Matter of Economics

    ERIC Educational Resources Information Center

    Modern Schools, 1977

    1977-01-01

    Recent developments in the field of indirect lighting and the use of high intensity discharge light sources reveal that the most efficient lighting system can also be the most economical. (Author/MLF)

  6. Indirect Ultraviolet-Reactivation of Phage λ

    PubMed Central

    George, Jacqueline; Devoret, Raymond; Radman, Miroslav

    1974-01-01

    When an F- recipient Escherichia coli K12 bacterium receives Hfr or F-lac+ DNA from an ultraviolet-irradiated donor, its capacity to promote DNA repair and mutagenesis of ultraviolet-damaged phage λ is substantially increased. We call this phenomenon indirect ultraviolet-reactivation, since its features are essentially the same as those of ultraviolet-reactivation; this repair process occurs in pyrimidine dimer excision-deficient strains and produces clear plaque mutations of the restored phage. Moreover, this process is similar to indirect ultraviolet-induction of prophage λ, since it is promoted by conjugation. However, contrarily to indirect induction, it is produced by Hfr donors and occurs in recipients restricting the incoming ultraviolet-damaged donor DNA. The occurrence of indirect ultraviolet-reactivation provides evidence for the existence in E. coli of an inducible error-prone mechanism for the repair of DNA. PMID:4589889

  7. AN INTEGRATED APPROACH TO AIR QUALITY USING IN SITU, SATELLITE, AND MODELED DATA - FOCUSED ON THE FUTURE OF EARTH OBSERVATIONS SYSTEM (EOS)

    EPA Science Inventory

    EPA through statutory mandates has monitored air, water, land and human health for the past several decades. The design of the ambient air monitoring networks, for the most part, has been loosely tied single-pollutant networks focused on large urban areas. These networks supply t...

  8. Direct and indirect effects in causal networks

    NASA Astrophysics Data System (ADS)

    Krämer, Andreas

    2013-03-01

    Literature-derived networks of biomolecular interactions representing cause-effect relationships generally contain many indirect relationships where the actually observed causal effect results from a sequence of events represented in the same network. A statistical method is developed, based on an Ising-like spin model operating on the edges of the network, to distinguish between direct and indirect effects using only the network structure itself. This allows to identify paths representing likely causation mechanisms.

  9. Indirect Liquefaction of Biomass to Transportation Fuels Via Mixed Oxygenated Intermediates

    SciTech Connect

    Tan, Eric C.D.

    2016-11-14

    This paper presents a comparative techno-economic analysis of four emerging conversion pathways from biomass to gasoline-, jet-, and diesel-range hydrocarbons via indirect liquefaction with specific focus on pathways utilizing oxygenated intermediates. The processing steps include: biomass-to-syngas via indirect gasification, gas cleanup, conversion of syngas to alcohols/oxygenates followed by conversion of alcohols/oxygenates to hydrocarbon blendstocks via dehydration, oligomerization, and hydrogenation.

  10. 48 CFR 742.770 - Negotiated indirect cost rate agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 742.770 Negotiated indirect cost... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Negotiated indirect cost... Negotiated Indirect Cost Rate Agreement, executed by both parties. The Negotiated Indirect Cost...

  11. 14 CFR 296.3 - Indirect cargo air carrier.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Indirect cargo air carrier. 296.3 Section... PROCEEDINGS) ECONOMIC REGULATIONS INDIRECT AIR TRANSPORTATION OF PROPERTY General § 296.3 Indirect cargo air carrier. An indirect cargo air carrier is any U.S. citizen who undertakes to engage indirectly in...

  12. 14 CFR 296.3 - Indirect cargo air carrier.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Indirect cargo air carrier. 296.3 Section... PROCEEDINGS) ECONOMIC REGULATIONS INDIRECT AIR TRANSPORTATION OF PROPERTY General § 296.3 Indirect cargo air carrier. An indirect cargo air carrier is any U.S. citizen who undertakes to engage indirectly in...

  13. Acknowledging adult bias: a focus-group approach to utilizing beauty salons as health-education portals for inner-city adolescent girls.

    PubMed

    Lieberman, Alexis; Harris, Diana

    2007-04-01

    To assess the feasibility of using beauticians as health literacy agents and beauty salons as health-education portals for adolescent, inner-city, African American girls, the authors conducted focus groups with 25 women: salon clients, salon owners, and medical students. Facilitators to program development included (a) beautician-client relationships, (b) teens' access to health information, and (c) beauticians as information resources. Barriers included (a) adult opinions of teen behaviors, (b) teen mistrust of adults, and (c) low health literacy of beauticians. In developing a health-education program for this population, beauticians and salons may be excellent health information agents and portals if barriers including beautician poor health literacy, adolescent mistrust in adults, and adults' anti-adolescent bias are improved. Program implementation must not solely focus on teens but should also include adult salon users, with the goal of reaching the teens first through these adults and, with time and trust, reaching the teens directly.

  14. A Focus on Problems of National Interest in the College General Chemistry Laboratory: The Effects of the Problem-Oriented Method Compared with Those of the Traditional Approach.

    ERIC Educational Resources Information Center

    Neman, Robert Lynn

    This study was designed to assess the effects of the problem-oriented method compared to those of the traditional approach in general chemistry at the college level. The problem-oriented course included topics such as air and water pollution, drug addiction and analysis, tetraethyl-lead additives, insecticides in the environment, and recycling of…

  15. An Outcomes-Focused Approach to the Accreditation Self-Study: A Description of the University of San Francisco Self-Study Process.

    ERIC Educational Resources Information Center

    Newton, Robert R.

    A structured approach to a 1980 accreditation self-study conducted at the University of San Francisco in preparation for a reaccreditation visit of the Western Association of Schools and Colleges is described. Assumptions and principles that governed the design of the self-study, steps in the study, and recommendations for future self-studies are…

  16. The Problems with a "Fact"-Focused Approach in Environmental Communication: The Case of Environmental Risk Information about Tidal Flat Developments in Japan

    ERIC Educational Resources Information Center

    Yamashita, Hiromi

    2015-01-01

    One of the main approaches used in communicating environmental issues to citizens is conveying "factual" information about a particular environment. However, despite previous research and recommendations made by critical environmental educators, there still seems to be a belief that the more "factual" information one can…

  17. The Value of Indirect Teaching Strategies in Enhancing Student-Coaches' Learning Engagement.

    PubMed

    Mesquita, Isabel; Coutinho, Patrícia; De Martin-Silva, Luciana; Parente, Bruno; Faria, Mário; Afonso, José

    2015-09-01

    This study aimed to examine the indirect teaching strategies adopted by a coach educator in terms of promoting student-coaches' engagement in a positive and active learning environment. The participants were an expert coach educator and seven student-coaches from an academic coaching setting. A mix method approach was used to collect data. Whilst video-recording and participant observations were used to collect data from the lessons, focus groups were adopted to recall the perceptions of student-coaches. The results showed that indirect teaching strategies (i.e., asking questions, showing signs of autonomy by monitoring the pace at which they completed tasks and actively engaging in the search for solutions to tasks) implemented by the coach educator promoted a supportive and challenging learning environment which, in turn, encouraged student-coaches to be more actively involved in the lessons. Additionally, the affective aspects of the relationship established with student-coaches (tone of voice, gestures, facial expressions, eye contact, physical contact and humor) led them to feel confident in exposing their doubts and opinions, and in learning in a more autonomous manner. Moreover, the practical lessons proved to be crucial in helping student-coaches to reach broader and deeper forms of understanding by allowing the application of theory to coaching practice. In conclusion, this study reinforces the value of indirect teaching strategies to stimulate an active learning environment. It further highlights the value of practical learning environments to better prepare neophyte coaches for dealing with the complex and dynamic nature of their professional reality. Key pointsBoth instructional and affective teaching indirect strategies used by the coach educator promoted a positive and challenging learning environment to student-coaches.The directness profile used by this coach educator (questioning, giving autonomy for problem solving and responsibility to regulate

  18. The Value of Indirect Teaching Strategies in Enhancing Student-Coaches’ Learning Engagement

    PubMed Central

    Mesquita, Isabel; Coutinho, Patrícia; De Martin-Silva, Luciana; Parente, Bruno; Faria, Mário; Afonso, José

    2015-01-01

    This study aimed to examine the indirect teaching strategies adopted by a coach educator in terms of promoting student-coaches’ engagement in a positive and active learning environment. The participants were an expert coach educator and seven student-coaches from an academic coaching setting. A mix method approach was used to collect data. Whilst video-recording and participant observations were used to collect data from the lessons, focus groups were adopted to recall the perceptions of student-coaches. The results showed that indirect teaching strategies (i.e., asking questions, showing signs of autonomy by monitoring the pace at which they completed tasks and actively engaging in the search for solutions to tasks) implemented by the coach educator promoted a supportive and challenging learning environment which, in turn, encouraged student-coaches to be more actively involved in the lessons. Additionally, the affective aspects of the relationship established with student-coaches (tone of voice, gestures, facial expressions, eye contact, physical contact and humor) led them to feel confident in exposing their doubts and opinions, and in learning in a more autonomous manner. Moreover, the practical lessons proved to be crucial in helping student-coaches to reach broader and deeper forms of understanding by allowing the application of theory to coaching practice. In conclusion, this study reinforces the value of indirect teaching strategies to stimulate an active learning environment. It further highlights the value of practical learning environments to better prepare neophyte coaches for dealing with the complex and dynamic nature of their professional reality. Key points Both instructional and affective teaching indirect strategies used by the coach educator promoted a positive and challenging learning environment to student-coaches. The directness profile used by this coach educator (questioning, giving autonomy for problem solving and responsibility to

  19. Known unknowns: indirect energy effects of information and communication technology

    NASA Astrophysics Data System (ADS)

    Horner, Nathaniel C.; Shehabi, Arman; Azevedo, Inês L.

    2016-10-01

    Background. There has been sustained and growing interest in characterizing the net energy impact of information and communication technology (ICT), which results from indirect effects offsetting (or amplifying) the energy directly consumed by ICT equipment. These indirect effects may be either positive or negative, and there is considerable disagreement as to the direction of this sign as well as the effect magnitude. Literature in this area ranges from studies focused on a single service (such as e-commerce versus traditional retail) to macroeconomic studies attempting to characterize the overall impact of ICT. Methods. We review the literature on the indirect energy effect of ICT found via Google Scholar, our own research, and input from other researchers in the field. The various studies are linked to an effect taxonomy, which is synthesized from several different hierarchies present in the literature. References are further grouped according to ICT service (e.g., e-commerce, telework) and summarized by scope, method, and quantitative and qualitative findings. Review results. Uncertainty persists in understanding the net energy effects of ICT. Results of indirect energy effect studies are highly sensitive to scoping decisions and assumptions made by the analyst. Uncertainty increases as the impact scope broadens, due to complex and interconnected effects. However, there is general agreement that ICT has large energy savings potential, but that the realization of this potential is highly dependent on deployment details and user behavior. Discussion. While the overall net effect of ICT is likely to remain unknown, this review suggests several guidelines for improving research quality in this area, including increased data collection, enhancing traditional modeling studies with sensitivity analysis, greater care in scoping, less confidence in characterizing aggregate impacts, more effort on understanding user behavior, and more contextual integration across the

  20. The association of personal resilience with stress, coping, and diabetes outcomes in adolescents with type 1 diabetes: variable- and person-focused approaches.

    PubMed

    Yi-Frazier, Joyce P; Yaptangco, Mona; Semana, Sharla; Buscaino, Emil; Thompson, Valeria; Cochrane, Katie; Tabile, Marissa; Alving, Erin; Rosenberg, Abby R

    2015-09-01

    This study explored the association between personal resilience and distress, coping, and diabetes outcomes in 50 adolescents with type 1 diabetes. Resilience was defined by a factor score derived from validated instruments measuring self-efficacy, optimism, and self-esteem. Variable- and person-focused methodologies were used to explore these associations. Low resilience was associated with higher distress, poor quality of life, and poor glycemic control. Participants with low resilience used more maladaptive coping strategies and were at greatest risk of poor outcomes. Findings suggest that resilience is a promising candidate for interventions designed to reduce distress and improve outcomes for adolescents with type 1 diabetes.

  1. A Bayesian approach for estimating under-reported dengue incidence with a focus on non-linear associations between climate and dengue in Dhaka, Bangladesh.

    PubMed

    Sharmin, Sifat; Glass, Kathryn; Viennet, Elvina; Harley, David

    2016-05-13

    Determining the relation between climate and dengue incidence is challenging due to under-reporting of disease and consequent biased incidence estimates. Non-linear associations between climate and incidence compound this. Here, we introduce a modelling framework to estimate dengue incidence from passive surveillance data while incorporating non-linear climate effects. We estimated the true number of cases per month using a Bayesian generalised linear model, developed in stages to adjust for under-reporting. A semi-parametric thin-plate spline approach was used to quantify non-linear climate effects. The approach was applied to data collected from the national dengue surveillance system of Bangladesh. The model estimated that only 2.8% (95% credible interval 2.7-2.8) of all cases in the capital Dhaka were reported through passive case reporting. The optimal mean monthly temperature for dengue transmission is 29℃ and average monthly rainfall above 15 mm decreases transmission. Our approach provides an estimate of true incidence and an understanding of the effects of temperature and rainfall on dengue transmission in Dhaka, Bangladesh.

  2. Estradiol: a rhythmic, inhibitory, indirect control of meal size.

    PubMed

    Eckel, Lisa A

    2004-08-01

    The classic analyses of the inhibitory effects of cholecystokinin (CCK) on meal size, conducted by Professor Gerard P. Smith and his colleagues at the Bourne Laboratory, inspired my initial interest in this field. My current research, which investigates the role of estradiol in the control of meal size, continues to be guided by Gerry's thoughtful, scientific approach to the study of ingestive behavior. In 1996, the year I arrived as a Postdoctoral Fellow at the Bourne Laboratory, Gerry published a new theory of the controls of meal size. In this important paper, Gerry proposed that the controls of meal size can be either direct or indirect. He argued that direct controls of meal size interact with peripheral, preabsorptive receptors that are sensitive to the chemical, mechanical, and colligative properties of ingested food and that indirect controls of meal size function to modulate the activity of direct controls. The purpose of this review is to illustrate how Gerry's theory has guided much of what is known about the mechanism by which estradiol inhibits food intake in female rats. I will provide evidence, primarily from behavioral studies of gonadally intact and ovariectomized rats, that estradiol exerts phasic and tonic inhibitory effects on food intake by acting as a rhythmic, inhibitory, indirect control of meal size.

  3. Direct and Indirect Dark Matter Detection in Gauge Theories

    SciTech Connect

    Queiroz, Farinaldo

    2013-01-01

    The Dark matter (DM) problem constitutes a key question at the interface among Particle Physics, Astrophysics and Cosmology. The observational data which have been accumulated in the last years point to an existence of non baryonic amount of DM. Since the Standard Model (SM) does not provide any candidate for such non-baryonic DM, the evidence of DM is a major indication for new physics beyond the SM. We will study in this work one of the most popular DM candidates, the so called WIMPs (Weakly Interacting Massive Particles) from a direct and indirect detection perspective. In order to approach the direct and indirect dection of DM in the context of Particle Physics in a more pedagogic way, we will begin our discussion talking about a minimal extension of the SM. Later we will work on the subject in a 3-3-1 model. Next, we will study the role of WIMPs in the Big Bang Nucleosynthesis. Lastly, we will look for indirect DM signals in the center of our galaxy using the NASA Satellite, called Fermi-LAT. Through a comprehensive analysis of the data events observed by Fermi-LAT and some background models, we will constrain the dark matter annihilation cross section for several annihilation channels and dark matter halo profiles.

  4. Household Health Costs: Direct, Indirect and Intangible

    PubMed Central

    YOUSEFI, Mehdi; ASSARI ARANI, Abbas; SAHABI, Bahram; KAZEMNEJAD, Anoshirvan; FAZAELI, Somayeh

    2014-01-01

    Abstract Background This study aimed at identifying components of the household health costs. Methods This study was a qualitative research conducted in two main phases. The first phase consisted of interviews with sample households selected in eight provinces of Iran. They were to identify components of the household health costs. In the second phase, components were determined as direct, indirect and intangible based on a content analysis. Results In the first phase of the study, 93 components of households’ health costs were identified. According to the content analysis, 44 components were categorized as direct costs, 10 components were indirect and 39 components were categorized as intangible. Conclusion All components of households’ health costs including: direct, indirect and intangible costs, should be considered in the planning and policy-making in the health system. PMID:26060744

  5. Bibliotherapy: an indirect approach to treatment of childhood aggression.

    PubMed

    Shechtman, Z

    1999-01-01

    The process of group therapy with five aggressive young boys, utilizing bibliotherapy as its primary mode of intervention, was investigated and is illustrated in this paper. The rationale for using affective bibliotherapy in a group context is given, the content of the program is described, and the process is fully displayed. The effectiveness of the treatment was studied in a single-subject design, comparing treatment children with their matched counterparts. Results pointed to reduced aggression of all the five treatment students, compared with no change in the control children, by self- and teacher report. In addition, results based on an analysis of transcripts showed increased constructive behavior in group for all participants. Although these results should not be generalized, they suggest an interesting line of research for future investigation.

  6. Exposure Assessment Tools by Approaches - Indirect Estimation (Scenario Evaluation)

    EPA Pesticide Factsheets

    EPA ExpoBox is a toolbox for exposure assessors. Its purpose is to provide a compendium of exposure assessment and risk characterization tools that will present comprehensive step-by-step guidance and links to relevant exposure assessment data bases, mode

  7. Unraveling the Persian Knot: Indirect Approaches towards Iran

    DTIC Science & Technology

    2009-05-01

    funds severely limiting clerical financial resources. As the clerical community became increasingly alienated , Khomeini publically emerged as the...rising rampant inflation. These price fixing measures greatly angered the bazaaris. Increasingly alienated bazaaris now believed the regime to be “an... Skull Press, Inc., 2005. Alexander, Yohah and Nanes, Allan, The United States and Iran, A Documentary History, Frederick, Maryland: University

  8. Contemporary Security Challenges: Irregular Warfare and Indirect Approaches

    DTIC Science & Technology

    2009-02-01

    Yarger Ph.D., History, Professor of National Security Policy , U.S. Army War College and JSOU Associate Fellow On the cover. A U.S. Special Forces...views, policy or position of the United States Government, Department of Defense, United States Special Operations Command, or the Joint Special...officer, provides an analysis of surrogate warfare, mandating changes in policy and doctrine to include “comprehensive guidance” from the U.S. government

  9. A hierarchic approach to examining panArctic vegetation with a focus on the linkages between remote sensing and plot-based studies.

    NASA Astrophysics Data System (ADS)

    Walker, D. A.; Daniëls, F. J. A.; Alsos, I. G.; Bhatt, U. S.; Breen, A. L.; Buchhorn, M.; Bültmann, H.; Edwards, M. E.; Ehrich, D.; Epstein, H. E.; Gould, W. A.; Ims, R. A.; Meltofte, H.; Murray, D. F.; Raynolds, M. K.; Talbot, S. S.

    2015-12-01

    A circumpolar view of Arctic vegetation developed with the advent of satellite-derived remote-sensing products. Interpretations of what the revealed patterns mean are dependent on a foundation of in-situ plot-based observations. Despite the importance of ground-based observations, only a few areas have been intensively sampled and mapped, mainly in the vicinity of permanent Arctic observatories. Much of the information is project specific and is based on sampling protocols that are difficult to compare across sites. Here, we demonstrate a more consistent multi-level hierarchic approach for vegetation description and analysis at the Toolik Lake Field Station, Alaska. We advocate for a well-coordinated, interdisciplinary network of vegetation observation stations. Key recommendations include: (1) Complete local floras for many more areas in than presently exist. Species names should be standardized using the Pan-Arctic Flora. (2) Permanently marked and replicated vegetation monitoring plots in the full range of habitats at each station. Methods of establishing and monitoring the plots should include consistent internationally accepted standards for vegetation data collection, vegetation classification, plot markings, and standardized approaches to describe the local environment, including photo points showing the vegetation and soils up close and in landscape view. (3) Standardized approaches for collecting in-situ time-series of spectral data. Standardized methods for collecting and analyzing phytomass data are especially needed. (4) Interdisciplinary studies. Vegetation observations should be conducted in concert with observations of soils, permafrost, animals and ecosystem processes at the same plots. (5) Periodic (perhaps every 5-10 years) ground-based surveys. These should include surveys of species composition, canopy structure, biomass, leaf-area index, and NDVI, along with high-resolution satellite-based remote-sensing products at the same time.

  10. Quantification of progress in indirect coal liquefaction

    SciTech Connect

    Gray, D.; ElSawy, A.; Tomlinson, G.

    1991-01-01

    The objective of this study is to quantify the economic and technical impact of incorporating various advanced technologies into the indirect coal liquefaction system. These advanced technologies include entrained flow Shell gasification and slurry-phase Fischer-Tropsch (F-T) synthesis. This objective was accomplished by substituting the Shell entrained goal gasifier system for the Lurgi and the advanced slurry F-T reactor for the Synthol and ARGE F-T systems in a SASOL-type indirect liquefaction facility. 4 refs., 3 figs., 2 tabs.

  11. The focal account: Indirect lie detection need not access unconscious, implicit knowledge.

    PubMed

    Street, Chris N H; Richardson, Daniel C

    2015-12-01

    People are poor lie detectors, but accuracy can be improved by making the judgment indirectly. In a typical demonstration, participants are not told that the experiment is about deception at all. Instead, they judge whether the speaker appears, say, tense or not. Surprisingly, these indirect judgments better reflect the speaker's veracity. A common explanation is that participants have an implicit awareness of deceptive behavior, even when they cannot explicitly identify it. We propose an alternative explanation. Attending to a range of behaviors, as explicit raters do, can lead to conflict: A speaker may be thinking hard (indicating deception) but not tense (indicating honesty). In 2 experiments, we show that the judgment (and in turn the correct classification rate) is the result of attending to a single behavior, as indirect raters are instructed to do. Indirect lie detection does not access implicit knowledge, but simply focuses the perceiver on more useful cues.

  12. Indirect Fourier transform in the context of statistical inference.

    PubMed

    Muthig, Michael; Prévost, Sylvain; Orglmeister, Reinhold; Gradzielski, Michael

    2016-09-01

    Inferring structural information from the intensity of a small-angle scattering (SAS) experiment is an ill-posed inverse problem. Thus, the determination of a solution is in general non-trivial. In this work, the indirect Fourier transform (IFT), which determines the pair distance distribution function from the intensity and hence yields structural information, is discussed within two different statistical inference approaches, namely a frequentist one and a Bayesian one, in order to determine a solution objectively From the frequentist approach the cross-validation method is obtained as a good practical objective function for selecting an IFT solution. Moreover, modern machine learning methods are employed to suppress oscillatory behaviour of the solution, hence extracting only meaningful features of the solution. By comparing the results yielded by the different methods presented here, the reliability of the outcome can be improved and thus the approach should enable more reliable information to be deduced from SAS experiments.

  13. A risk-based focused decision-management approach for justifying characterization of Hanford tank waste. June 1996, Revision 1; April 1997, Revision 2

    SciTech Connect

    Colson, S.D.; Gephart, R.E.; Hunter, V.L.; Janata, J.; Morgan, L.G.

    1997-12-31

    This report describes a disciplined, risk-based decision-making approach for determining characterization needs and resolving safety issues during the storage and remediation of radioactive waste stored in Hanford tanks. The strategy recommended uses interactive problem evaluation and decision analysis methods commonly used in industry to solve problems under conditions of uncertainty (i.e., lack of perfect knowledge). It acknowledges that problem resolution comes through both the application of high-quality science and human decisions based upon preferences and sometimes hard-to-compare choices. It recognizes that to firmly resolve a safety problem, the controlling waste characteristics and chemical phenomena must be measurable or estimated to an acceptable level of confidence tailored to the decision being made.

  14. Host resistance, population structure and the long-term persistence of bubonic plague: contributions of a modelling approach in the Malagasy focus.

    PubMed

    Gascuel, Fanny; Choisy, Marc; Duplantier, Jean-Marc; Débarre, Florence; Brouat, Carine

    2013-01-01

    Although bubonic plague is an endemic zoonosis in many countries around the world, the factors responsible for the persistence of this highly virulent disease remain poorly known. Classically, the endemic persistence of plague is suspected to be due to the coexistence of plague resistant and plague susceptible rodents in natural foci, and/or to a metapopulation structure of reservoirs. Here, we test separately the effect of each of these factors on the long-term persistence of plague. We analyse the dynamics and equilibria of a model of plague propagation, consistent with plague ecology in Madagascar, a major focus where this disease is endemic since the 1920s in central highlands. By combining deterministic and stochastic analyses of this model, and including sensitivity analyses, we show that (i) endemicity is favoured by intermediate host population sizes, (ii) in large host populations, the presence of resistant rats is sufficient to explain long-term persistence of plague, and (iii) the metapopulation structure of susceptible host populations alone can also account for plague endemicity, thanks to both subdivision and the subsequent reduction in the size of subpopulations, and extinction-recolonization dynamics of the disease. In the light of these results, we suggest scenarios to explain the localized presence of plague in Madagascar.

  15. ENHANCING RESEARCH ETHICS REVIEW SYSTEMS IN EGYPT: THE FOCUS OF AN INTERNATIONAL TRAINING PROGRAM INFORMED BY AN ECOLOGICAL DEVELOPMENTAL APPROACH TO ENHANCING RESEARCH ETHICS CAPACITY

    PubMed Central

    Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry

    2014-01-01

    Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed “too great an emphasis on guidelines and research ethics review”, which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities. PMID:24894063

  16. Enhancing Research Ethics Review Systems in Egypt: The Focus of an International Training Program Informed by an Ecological Developmental Approach to Enhancing Research Ethics Capacity.

    PubMed

    Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry

    2015-12-01

    Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed 'too great an emphasis on guidelines and research ethics review', which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities.

  17. Approaches to phase 1 clinical trial design focused on safety, efficiency, and selected patient populations: a report from the clinical trial design task force of the national cancer institute investigational drug steering committee.

    PubMed

    Ivy, S Percy; Siu, Lillian L; Garrett-Mayer, Elizabeth; Rubinstein, Larry

    2010-03-15

    The goals and objectives of phase 1 clinical trials are changing to include further evaluation of endpoints such as molecular targeted effects, in addition to dose-toxicity profile of the investigational agent. Because of these changes in focus, the National Cancer Institute and Investigational Drug Steering Committee's Task Force on Clinical Trial Design met to evaluate the most efficient ways to design and implement early clinical trials with novel therapeutics. Clinical approaches discussed included the conventional 3 + 3 cohort expansion phase 1 design, multi-institutional phase 1 studies, accelerated titration designs, continual reassessment methods, the study of specific target patient populations, and phase 0 studies. Each of these approaches uniquely contributes to some aspect of the phase 1 study, with all focused on dose and schedule determination, patient safety, and limited patient exposure to ineffective doses of investigational agent. The benefit of labor-intensive generation of preliminary biomarker evidence of target inhibition, as well as the value of molecular profiling of the study population, is considered. New drug development is expensive and the failure rate remains high. By identifying patient populations expected to respond to the study agent and tailoring the treatment with a novel drug, investigators will be one step closer to personalizing cancer treatment. The "fail early and fast" approach is acceptable if the appropriate patient population is evaluated in the phase 1 trial. The approaches outlined in this overview address the merits, advantages, disadvantages, and obstacles encountered during first in human studies.

  18. 19 CFR 10.924 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.924 Section 10.924 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Peru Trade Promotion...

  19. 19 CFR 10.924 - Indirect materials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Indirect materials. 10.924 Section 10.924 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Peru Trade Promotion...

  20. 19 CFR 10.1024 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.1024 Section 10.1024 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Korea Free...

  1. 19 CFR 10.1024 - Indirect materials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Indirect materials. 10.1024 Section 10.1024 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Korea Free...

  2. Have Indirect Emissions from Biofuels Been Exaggerated?

    NASA Astrophysics Data System (ADS)

    Kicklighter, D. W.; Gurgel, A.; Melillo, J. M.; Reilly, J. M.; Cronin, T.; Felzer, B. S.; Paltsev, S.; Schlosser, C. A.; Sokolov, A. P.

    2009-12-01

    The production of biofuels may lead to enhanced greenhouse gas (GHG) emissions from land to the atmosphere either by directly converting land to biofuel crops, or indirectly, by causing the displacement of food production and other land uses which then require additional land conversions. The importance of indirect GHG emissions from biofuel-related displacement of food production and other land uses is not known and is highly controversial. Here, we examine the direct and indirect land-use emissions over the 21st century from an expanded global bioenergy program, using a linked economic and terrestrial biogeochemistry modeling system under two different land use policies. We account for the dynamics of potential carbon losses or gains from land-use change along with nitrous oxide emissions from increased N fertilizer application. We find that: 1) indirect emissions from land use are responsible for substantially more carbon loss (up to twice as much) than direct land use; 2) increased nitrous oxide emissions over the century are more important to the GHG balance than the carbon losses themselves; 3) the GHG effects of biofuels change in both sign and magnitude over time so that the GHG cost/benefit of biofuels depends on the time horizon considered; and 4) the economics of biofuels become favorable sooner with the protection of forests. While biofuels can be an effective low carbon energy source from a GHG balance perspective, the associated land conversions may lead to an unacceptable loss of other ecosystem services.

  3. Time Spent in Indirect Nursing Care

    DTIC Science & Technology

    1983-09-01

    Part of the FY 83 Army Study Program and intended to augment the FY 81 completed study titled ’ Nursing Care Hours Standards’ by providing valid and...reliable percentages for hospital patient nursing care unit requirements (i.e., direct care, indirect care, and non-productive time). These data

  4. 19 CFR 10.776 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.776 Section 10.776 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Morocco Free Trade...

  5. Indirect processes in electron-ion scattering

    SciTech Connect

    Bottcher, C.; Griffin, D.C.; Pindzola, M.S.; Phaneuf, R.A.

    1983-10-01

    A summary is given of an informal workshop held at Oak Ridge National Laboratory on June 22-23, 1983, in which the current status of theoretical calculations of indirect processes in electron-ion scattering was reviewed. Processes of particular interest in astrophysical and fusion plasmas were emphasized. Topics discussed include atomic structure effects, electron-impact ionization, and dielectronic recombination.

  6. Astrophysical Reaction Rates Obtained By Indirect Techniques

    SciTech Connect

    Tribble, R. E.; Al-Abdullah, T.; Alharbi, A.; Banu, A.; Chen, X.; Clark, H. L.; Fu, C.; Gagliardi, C. A.; Hardy, J. C.; Iacob, V. E.; Lui, Y.-W.; McCleskey, M.; Mukhamedzhanov, A.; Nica, N.; Park, H. I.; Roeder, B.; Simmons, E.; Tabacaru, G.; Tokimoto, Y.; Trache, L.

    2010-08-12

    Indirect techniques have been used to obtain information about reaction rates for several proton capture reactions that occur on short-lived nuclei. The techniques used to carry out the measurements are reviewed and the results obtained are presented. Also future prospects for further measurements with a new facility, T-REX are discussed.

  7. 19 CFR 18.43 - Indirect exportation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... port to another for actual exportation at the second port, any export declarations required to be... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect exportation. 18.43 Section 18.43 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Merchandise Not Otherwise Subject to Customs Control...

  8. 19 CFR 18.26 - Indirect exportation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... merchandise to be exported and provide such evidence of exportation as required by the port director under... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect exportation. 18.26 Section 18.26 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Exportation from Customs Custody of Merchandise Unentered...

  9. 19 CFR 10.460 - Indirect materials.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect materials. 10.460 Section 10.460 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Chile Free Trade Agreement...

  10. An Indirect Test of Oral Proficiency.

    ERIC Educational Resources Information Center

    Herzog, Martha; Shaw, Victor

    The development of an indirect oral proficiency test for foreign languages by the Defense Language Institute is described. The technique uses taped questions to elicit answers, also taped, that are evaluated according to the Foreign Service Institute's oral proficiency rating scale of 0 to 5. Tape recordings are used because of the large numbers…

  11. 19 CFR 10.541 - Indirect materials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Indirect materials. 10.541 Section 10.541 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. United States-Singapore Free Trade...

  12. Utilization of adjuvant arthritis model for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress.

    PubMed

    Bauerová, Katarína; Poništ, Silvester; Mihalová, Danica; Dráfi, František; Kuncírová, Viera

    2011-03-01

    As a number of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration, increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The safety of long-term therapy of RA is very important as patients with RA are usually treated for two or more decades. This experimental overview is focused on some promising substances and their combinations with the standard antirheumatic drug - methotrexate (Mtx) for treatment of rheumatoid arthritis. The adjuvant arthritis model in Lewis rats was used for evaluation of antiinflammatory efficacy of the substances evaluated. Mtx was administered in the oral dose of 0.3 mg/kg b.w. twice a week. Natural and synthetic antioxidants were administered in the daily oral dose of 20 mg/kg b.w for coenzyme Q(10) (CoQ(10)), 150 mg/kg b.w for carnosine (Carn), 15 mg/kg b.w. for stobadine dipalmitate (Stb) and its derivative SMe1.2HCl (SMe1), and 30 mg/kg b.w. for pinosylvin (Pin) or pterostilbene (Pte). Mtx in the oral dose of 0.4 mg/kg b.w. twice a week was combined with Pin in the oral daily dose of 50 mg/kg b.w. Clinical (hind paw volume - HPV), biochemical (activity of GGT in joint and level of TBARS in plasma), and immunological (IL-1 in plasma) parameters were assessed. Our results achieved with different antioxidants in monotherapies showed a reduction of oxidative stress in adjuvant arthritis independently of the chemical structure of the compounds. Pin was the most effective antioxidant tested in decreasing HPV. All combinations tested showed a higher efficacy in affecting biochemical or immunological parameters than Mtx administered in monotherapy. The findings showed the benefit of antioxidant compounds for their use in combination therapy with methotrexate.

  13. A multidisciplinary approach to study a couple of monozygotic twins discordant for the chronic fatigue syndrome: a focus on potential salivary biomarkers

    PubMed Central

    2013-01-01

    Background Chronic Fatigue Syndrome (CFS) is a severe, systemic illness characterized by persistent, debilitating and medically unexplained fatigue. The etiology and pathophysiology of CFS remains obscure, and diagnosis is formulated through the patient’s history and exclusion of other medical causes. Thereby, the availability of biomarkers for CFS could be useful for clinical research. In the present study, we used a proteomic approach to evaluate the global changes in the salivary profile in a couple of monozygotic twins who were discordant for CFS. The aim was to evaluate differences of salivary protein expression in the CFS patient in respect to his healthy twin. Methods Saliva samples were submitted to two-dimensional electrophoresis (2DE). The gels were stained with Sypro, and a comparison between CFS subject and the healthy one was performed by the software Progenesis Same Spot including the Analysis of variance (ANOVA test). The proteins spot found with a ≥2-fold spot quantity change and p<0.05 were identified by Nano-liquid chromatography electrospray ionization tandem mass spectrometry. To validate the expression changes found with 2DE of 5 proteins (14-3-3 protein zeta/delta, cyclophilin A, Cystatin-C, Protein S100-A7, and zinc-alpha-2-glycoprotein), we used the western blot analysis. Moreover, proteins differentially expressed were functionally analyzed using the Ingenuity Pathways Analysis software with the aim to determine the predominant canonical pathways and the interaction network involved. Results The analysis of the protein profiles allowed us to find 13 proteins with a different expression in CFS in respect to control. Nine spots were up-regulated in CFS and 4 down-regulated. These proteins belong to different functional classes, such as inflammatory response, immune system and metabolism. In particular, as shown by the pathway analysis, the network built with our proteins highlights the involvement of inflammatory response in CFS

  14. An exploration of a restorative space: a creative approach to reflection for nurse lecturer's focused on experiences of compassion in the workplace.

    PubMed

    Smith, Stephen; Gentleman, Mandy; Loads, Daphne; Pullin, Simon

    2014-09-01

    This study was undertaken as part of a larger programme of research; the Leadership in Compassionate Care Programme. The aim of this study was to explore and respond to the perceptions of nurse lecturers in regard to experiences of compassion in the workplace. A participatory action research approach was adopted. The study took place in a large school of nursing and midwifery in the United Kingdom, eight lecturers participated in this study. A series of four facilitated reflective workshops titled a restorative space were provided and participants used the medium of collage as a process for reflection. Data was gathered in the form of collages, field and reflective notes. Data analysis involved an iterative process between facilitators and participants during the workshops and resulting actions were implemented. Findings from this study identified three key themes related to compassion in the workplace; leadership, culture, professional and personal development. Actions identified and implemented as a consequence of these findings included opportunities for lecturers to participate in a leadership development programme and implementing rapid feedback processes between lecturers and the senior management team. The restorative space workshops and utilisation of the creative medium of collage provided a valuable process for practitioners to collaboratively reflect on their workplace experiences.

  15. Focus cues affect perceived depth

    PubMed Central

    Watt, Simon J.; Akeley, Kurt; Ernst, Marc O.; Banks, Martin S.

    2007-01-01

    Depth information from focus cues—accommodation and the gradient of retinal blur—is typically incorrect in three-dimensional (3-D) displays because the light comes from a planar display surface. If the visual system incorporates information from focus cues into its calculation of 3-D scene parameters, this could cause distortions in perceived depth even when the 2-D retinal images are geometrically correct. In Experiment 1 we measured the direct contribution of focus cues to perceived slant by varying independently the physical slant of the display surface and the slant of a simulated surface specified by binocular disparity (binocular viewing) or perspective/texture (monocular viewing). In the binocular condition, slant estimates were unaffected by display slant. In the monocular condition, display slant had a systematic effect on slant estimates. Estimates were consistent with a weighted average of slant from focus cues and slant from disparity/texture, where the cue weights are determined by the reliability of each cue. In Experiment 2, we examined whether focus cues also have an indirect effect on perceived slant via the distance estimate used in disparity scaling. We varied independently the simulated distance and the focal distance to a disparity-defined 3-D stimulus. Perceived slant was systematically affected by changes in focal distance. Accordingly, depth constancy (with respect to simulated distance) was significantly reduced when focal distance was held constant compared to when it varied appropriately with the simulated distance to the stimulus. The results of both experiments show that focus cues can contribute to estimates of 3-D scene parameters. Inappropriate focus cues in typical 3-D displays may therefore contribute to distortions in perceived space. PMID:16441189

  16. Cruel intentions on television and in real life: can viewing indirect aggression increase viewers' subsequent indirect aggression?

    PubMed

    Coyne, Sarah M; Archer, John; Eslea, Mike

    2004-07-01

    Numerous studies have shown that viewing violence in the media can influence an individual's subsequent aggression, but none have examined the effect of viewing indirect aggression. This study examines the immediate effect of viewing indirect and direct aggression on subsequent indirect aggression among 199 children ages 11 to 14 years. They were shown an indirect, direct, or no-aggression video and their subsequent indirect aggression was measured by negative evaluation of a confederate and responses to a vignette. Participants viewing indirect or direct aggression gave a more negative evaluation of and less money to a confederate than participants viewing no-aggression. Participants viewing indirect aggression gave less money to the confederate than those viewing direct aggression. Participants viewing indirect aggression gave more indirectly aggressive responses to an ambiguous situation and participants viewing direct aggression gave more directly aggressive responses. This study provides the first evidence that viewing indirect aggression in the media can have an immediate impact on subsequent aggression.

  17. The true cost of cardiovascular imaging: focusing on downstream, indirect, and environmental costs

    PubMed Central

    2013-01-01

    To develop a more realistic assessment of costs, herein named “true” costs, the extra-cancer from medical radiation, environmental damage from imaging paraphernalia and radioactive wastes must be included as long-term costs from imaging examinations. It is urgent to define the “true” costs across imaging modalities as it interferes on physicians’ decision to request an exam and on research projects such as cost-effectiveness analysis. Cardiology is the specialty that most will benefit from the outcome as cardiovascular exams represent almost 30% of the total exams acquired annually worldwide. PMID:23594829

  18. Mexican Indirection: How To Help Mexican ESL Writers Channel Their Energies into Focused Essays.

    ERIC Educational Resources Information Center

    Ransdell, D. R.

    The fact that a writer's culture influences the composing style is undeniable. Spanish speakers writing in English often allow their points to "leap around," perhaps constituting a pattern the instructor does not see. In "Beyond Culture," Edward Hall explains that cultures operate under either "monochronic" or…

  19. Indirect emissions from biofuels: how important?

    PubMed

    Melillo, Jerry M; Reilly, John M; Kicklighter, David W; Gurgel, Angelo C; Cronin, Timothy W; Paltsev, Sergey; Felzer, Benjamin S; Wang, Xiaodong; Sokolov, Andrei P; Schlosser, C Adam

    2009-12-04

    A global biofuels program will lead to intense pressures on land supply and can increase greenhouse gas emissions from land-use changes. Using linked economic and terrestrial biogeochemistry models, we examined direct and indirect effects of possible land-use changes from an expanded global cellulosic bioenergy program on greenhouse gas emissions over the 21st century. Our model predicts that indirect land use will be responsible for substantially more carbon loss (up to twice as much) than direct land use; however, because of predicted increases in fertilizer use, nitrous oxide emissions will be more important than carbon losses themselves in terms of warming potential. A global greenhouse gas emissions policy that protects forests and encourages best practices for nitrogen fertilizer use can dramatically reduce emissions associated with biofuels production.

  20. Real medical benefit assessed by indirect comparison.

    PubMed

    Falissard, Bruno; Zylberman, Myriam; Cucherat, Michel; Izard, Valérie; Meyer, François

    2009-01-01

    Frequently, in data packages submitted for Marketing Approval to the CHMP, there is a lack of relevant head-to-head comparisons of medicinal products that could enable national authorities responsible for the approval of reimbursement to assess the Added Therapeutic Value (ASMR) of new clinical entities or line extensions of existing therapies.Indirect or mixed treatment comparisons (MTC) are methods stemming from the field of meta-analysis that have been designed to tackle this problem. Adjusted indirect comparisons, meta-regressions, mixed models, Bayesian network analyses pool results of randomised controlled trials (RCTs), enabling a quantitative synthesis.The REAL procedure, recently developed by the HAS (French National Authority for Health), is a mixture of an MTC and effect model based on expert opinions. It is intended to translate the efficacy observed in the trials into effectiveness expected in day-to-day clinical practice in France.

  1. Indirect Acquisition of Information in Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Ballesteros, M.; Fraas, M.; Fröhlich, J.; Schubnel, B.

    2016-02-01

    Long sequences of successive direct (projective) measurements or observations of just a few "uninteresting" physical quantities pertaining to a quantum system, such as clicks of some detectors, may reveal indirect, but precise and unambiguous information on the values of some very "interesting" observables of the system. In this paper, the mathematics underlying this claim is developed; i.e., we attempt to contribute to a mathematical theory of indirect and, in particular, non-demolition observations and measurements in quantum mechanics. Our attempt leads us to make some novel uses of classical notions and results of probability theory, such as the "algebra of functions measurable at infinity", the Central Limit Theorem, results concerning relative entropy and its role in the theory of large deviations, etc.

  2. Color indirect effects on melatonin regulation

    NASA Astrophysics Data System (ADS)

    Mian, Tian; Liu, Timon C.; Li, Yan

    2002-04-01

    Color indirect effect (CIE) is referred to as the physiological and psychological effects of color resulting from color vision. In previous papers, we have studied CIE from the viewpoints of the integrated western and Chinese traditional medicine, put forward the color-autonomic- nervous-subsystem model (CAM), and provided its time-theory foundation. In this paper, we applied it to study light effects on melatonin regulation in humans, and suggested that it is CIE that mediates light effects on melatonin suppression.

  3. Aerosol indirect effect dictated by liquid clouds

    NASA Astrophysics Data System (ADS)

    Christensen, Matthew W.; Chen, Yi-Chun; Stephens, Graeme L.

    2016-12-01

    Anthropogenic aerosols have been shown to enhance the solar reflection from warm liquid clouds and mask part of the warming due to the buildup of greenhouse gases. However, very little is known about the effects of aerosol on mixed-phase stratiform clouds as well as other cloud regimes including cumulus, altocumulus, nimbostratus, deep convection, and anvil cirrus. These additional cloud categories are ubiquitous and typically overlooked in satellite-based assessments of the global aerosol indirect forcing. Here we provide their contribution to the aerosol indirect forcing estimate using satellite data collected from several colocated sensors in the A-train for the period 2006-2010. Cloud type is determined according to the 2B-CLDCLASS-LIDAR CloudSat product, and the observations are matched to the radiative flux measurements from CERES (Clouds and the Earth's Radiant Energy System) and aerosol retrievals from MODIS (MODerate resolution Imaging Spectroradiometer). The oceanic mean aerosol indirect forcing is estimated to be -0.20 ± 0.31 W m-2 with warm low-level cloud largely dictating the strength of the response (-0.36 ± 0.21 W m-2) due to their abundance and strong cloud albedo effect. Contributions from mixed-phase low-level cloud (0.01 ± 0.06 W m-2) and convective cloud (0.15 ± 0.23 W m-2) are positive and buffer the system due to strong aerosol-cloud feedbacks that reduce the cloud albedo effect and/or lead to convective invigoration causing a countering positive longwave warming response. By combining all major cloud categories together, aerosol indirect forcing decreases and now contains positive values in the uncertainty estimate.

  4. Effects of Direct and Indirect Instruction on Fostering Decision-Making Competence in Socioscientific Issues

    ERIC Educational Resources Information Center

    Bottcher, Florian; Meisert, Anke

    2013-01-01

    In this study the effects of different learning environments on the promotion of decision-making competence for the socioscientific issue of genetically modified crops is investigated. The comparison focuses on direct vs. indirect instructions. Therefore on the one hand a sophisticated decision-making strategy was presented to the directly…

  5. Accounting for the Full Cost of Research. A Study of Indirect Costs.

    ERIC Educational Resources Information Center

    Zuiches, James J.; Vallely, Rebecca

    Faculty and administrative concern over the rising indirect cost rates at Cornell University (New York) precipitated this study, focusing on research funding and the expenses not easily identifiable with specific projects. Some of the questions addressed include: what are the costs, who pays for them, and which arrangements, policies,…

  6. Fishing indirectly structures macroalgal assemblages by altering herbivore behavior.

    PubMed

    Madin, Elizabeth M P; Gaines, Steven D; Madin, Joshua S; Warner, Robert R

    2010-12-01

    Fishing has clear direct effects on harvested species, but its cascading, indirect effects are less well understood. Fishing disproportionately removes larger, predatory fishes from marine food webs. Most studies of the consequent indirect effects focus on density-mediated interactions where predator removal alternately drives increases and decreases in abundances of successively lower trophic-level species. While prey may increase in number with fewer predators, they may also alter their behavior. When such behavioral responses impact the food resources of prey species, behaviorally mediated trophic cascades can dramatically shape landscapes. It remains unclear whether this pathway of change is typically triggered by ocean fishing. By coupling a simple foraging model with empirical observations from coral reefs, we provide a mechanistic basis for understanding and predicting how predator harvest can alter the landscape of risk for herbivores and consequently drive dramatic changes in primary producer distributions. These results broaden trophic cascade predictions for fisheries to include behavioral changes. They also provide a framework for detecting the presence and magnitude of behaviorally mediated cascades. This knowledge will help to reconcile the disparity between expected and observed patterns of fishing-induced cascades in the sea.

  7. Indirectly Encoding Running and Jumping Sodarace Creatures for Artificial Life.

    PubMed

    Szerlip, Paul; Stanley, Kenneth O

    2015-01-01

    This article presents a lightweight platform for evolving two-dimensional artificial creatures. The aim of providing such a platform is to reduce the barrier to entry for researchers interested in evolving creatures for artificial life experiments. In effect the novel platform, which is inspired by the Sodarace construction set, makes it easy to set up creative scenarios that test the abilities of Sodarace-like creatures made of masses and springs. In this way it allows the researcher to focus on evolutionary algorithms and dynamics. The new indirectly encoded Sodarace (IESoR) system introduced in this article extends the original Sodarace by enabling the evolution of significantly more complex and regular creature morphologies. These morphologies are themselves encoded by compositional pattern-producing networks (CPPNs), an indirect encoding previously shown effective at encoding regularities and symmetries in structure. The capability of this lightweight system to facilitate research in artificial life is then demonstrated through both walking and jumping domains, in which IESoR discovers a wide breadth of strategies through novelty search with local competition.

  8. Friends of friends: are indirect connections in social networks important to animal behaviour?

    PubMed Central

    Brent, Lauren J. N.

    2015-01-01

    Friend of a friend relationships, or the indirect connections between people, influence our health, well-being, financial success and reproductive output. As with humans, social behaviours in other animals often occur within a broad interconnected network of social ties. Yet studies of animal social behaviour tend to focus on associations between pairs of individuals. With the increase in popularity of social network analysis, researchers have started to look beyond the dyad to examine the role of indirect connections in animal societies. Here, I provide an overview of the new knowledge that has been uncovered by these studies. I focus on research that has addressed both the causes of social behaviours, i.e. the cognitive and genetic basis of indirect connections, as well as their consequences, i.e. the impact of indirect connections on social cohesion, information transfer, cultural practices and fitness. From these studies, it is apparent that indirect connections play an important role in animal behaviour, although future research is needed to clarify their contribution. PMID:25937639

  9. Friends of friends: are indirect connections in social networks important to animal behaviour?

    PubMed

    Brent, Lauren J N

    2015-05-01

    Friend of a friend relationships, or the indirect connections between people, influence our health, well-being, financial success and reproductive output. As with humans, social behaviours in other animals often occur within a broad interconnected network of social ties. Yet studies of animal social behaviour tend to focus on associations between pairs of individuals. With the increase in popularity of social network analysis, researchers have started to look beyond the dyad to examine the role of indirect connections in animal societies. Here, I provide an overview of the new knowledge that has been uncovered by these studies. I focus on research that has addressed both the causes of social behaviours, i.e. the cognitive and genetic basis of indirect connections, as well as their consequences, i.e. the impact of indirect connections on social cohesion, information transfer, cultural practices and fitness. From these studies, it is apparent that indirect connections play an important role in animal behaviour, although future research is needed to clarify their contribution.

  10. SPSS and SAS procedures for estimating indirect effects in simple mediation models.

    PubMed

    Preacher, Kristopher J; Hayes, Andrew F

    2004-11-01

    Researchers often conduct mediation analysis in order to indirectly assess the effect of a proposed cause on some outcome through a proposed mediator. The utility of mediation analysis stems from its ability to go beyond the merely descriptive to a more functional understanding of the relationships among variables. A necessary component of mediation is a statistically and practically significant indirect effect. Although mediation hypotheses are frequently explored in psychological research, formal significance tests of indirect effects are rarely conducted. After a brief overview of mediation, we argue the importance of directly testing the significance of indirect effects and provide SPSS and SAS macros that facilitate estimation of the indirect effect with a normal theory approach and a bootstrap approach to obtaining confidence intervals, as well as the traditional approach advocated by Baron and Kenny (1986). We hope that this discussion and the macros will enhance the frequency of formal mediation tests in the psychology literature. Electronic copies of these macros may be downloaded from the Psychonomic Society's Web archive at www.psychonomic.org/archive/.

  11. Spatially indirect excitons in coupled quantum wells

    SciTech Connect

    Lai, Chih-Wei Eddy

    2004-03-01

    Microscopic quantum phenomena such as interference or phase coherence between different quantum states are rarely manifest in macroscopic systems due to a lack of significant correlation between different states. An exciton system is one candidate for observation of possible quantum collective effects. In the dilute limit, excitons in semiconductors behave as bosons and are expected to undergo Bose-Einstein condensation (BEC) at a temperature several orders of magnitude higher than for atomic BEC because of their light mass. Furthermore, well-developed modern semiconductor technologies offer flexible manipulations of an exciton system. Realization of BEC in solid-state systems can thus provide new opportunities for macroscopic quantum coherence research. In semiconductor coupled quantum wells (CQW) under across-well static electric field, excitons exist as separately confined electron-hole pairs. These spatially indirect excitons exhibit a radiative recombination time much longer than their thermal relaxation time a unique feature in direct band gap semiconductor based structures. Their mutual repulsive dipole interaction further stabilizes the exciton system at low temperature and screens in-plane disorder more effectively. All these features make indirect excitons in CQW a promising system to search for quantum collective effects. Properties of indirect excitons in CQW have been analyzed and investigated extensively. The experimental results based on time-integrated or time-resolved spatially-resolved photoluminescence (PL) spectroscopy and imaging are reported in two categories. (i) Generic indirect exciton systems: general properties of indirect excitons such as the dependence of exciton energy and lifetime on electric fields and densities were examined. (ii) Quasi-two-dimensional confined exciton systems: highly statistically degenerate exciton systems containing more than tens of thousands of excitons within areas as small as (10 micrometer)2 were

  12. Transport of indirect excitons in high magnetic fields

    NASA Astrophysics Data System (ADS)

    Kuznetsova, Y. Y.; Dorow, C. J.; Calman, E. V.; Butov, L. V.; Wilkes, J.; Muljarov, E. A.; Campman, K. L.; Gossard, A. C.

    2017-03-01

    We present spatially and spectrally resolved photoluminescence measurements of indirect excitons in high magnetic fields. Long indirect exciton lifetimes give the opportunity to measure magnetoexciton transport by optical imaging. Indirect excitons formed from electrons and holes at zeroth Landau levels (0e-0h indirect magnetoexcitons) travel over large distances and form a ring emission pattern around the excitation spot. In contrast, the spatial profiles of 1e-1h and 2e-2h indirect magnetoexciton emission closely follow the laser excitation profile. The 0e-0h indirect magnetoexciton transport distance reduces with increasing magnetic field. These effects are explained in terms of magnetoexciton energy relaxation and effective mass enhancement.

  13. [Autoantibody detection by indirect immunofluorescence on HEp-2 cells].

    PubMed

    Sack, U; Conrad, K; Csernok, E; Frank, I; Hiepe, F; Krieger, T; Kromminga, A; Landenberg, P von; Messer, G; Witte, T; Mierau, R

    2009-06-01

    Systemic autoimmune diseases are characterized by the presence of antinuclear autoantibodies (ANA). Diluted patient sera are typically used to screen for the presence of ANA by immunfluorescence microscopy with fixed HEp-2 cells. Despite high-quality test kits, reports of different laboratories frequently present controversial results. This article recommends unified processing and interpretation of HEp-2 based screening for autoantibodies. Suggestions are made for the selection of high-quality test kits, optimized processing and diagnostic procedures. In addition to a relevant clinical diagnosis and an experienced laboratory specialist, the following procedure is highly recommended to achieve good laboratory practice: Initial HEp-2 based screening by indirect immunofluorescence, starting with a 1:80 serum dilution, and evaluation in a bright fluorescence microscope, pathological values from a titer of 1:160 upwards, internal quality checks and unified interpretation. We aim to improve diagnosis and care of patients with autoimmune diseases as a central focus of the European Autoimmunity Standardization Initiative (EASI).

  14. Indirect excitons in hydrogen-doped ZnO

    NASA Astrophysics Data System (ADS)

    Zhu, Liangchen; Lem, Laurent L. C.; Nguyen, Thien-Phap; Fair, Kit; Ali, Sajid; Ford, Michael J.; Phillips, Matthew R.; Ton-That, Cuong

    2017-03-01

    We present a correlative experimental and theoretical study of bound excitons in hydrogen-doped ZnO, with a particular focus on the dynamics of their metastable state confined in the sub-surface region, using a combination of surface-sensitive characterisation techniques and density functional theory calculations. A metastable sub-surface emission at 3.31 eV found in H-doped ZnO is attributed to the radiative recombination of indirect excitons localised at basal plane stacking faults (BSFs) where the excitonic transition involves electrons bound to bond-centre hydrogen donors in the potential well of the BSF. Additionally, our work shows the electrical transport of ZnO Schottky junctions is dominated by electrons confined at BSFs in the near-surface region.

  15. The SWOT Team Approach: Focusing on Minorities.

    ERIC Educational Resources Information Center

    Gorski, Susan E.

    1991-01-01

    Underscores the applicability of marketing principles to minority student recruitment and retention at community colleges. Proposes the assessment of an institution's Strengths, Weaknesses, and external Opportunities and Threats (SWOT) to strategically market the college. Considers the development of a plan for action based on the SWOT analysis.…

  16. Indirect drive ignition at the National Ignition Facility

    DOE PAGES

    Meezan, N. B.; Edwards, M. J.; Hurricane, O. A.; ...

    2016-10-27

    This article reviews scientific results from the pursuit of indirect drive ignition on the National Ignition Facility (NIF) and describes the program's forward looking research directions. In indirect drive on the NIF, laser beams heat an x-ray enclosure called a hohlraum that surrounds a spherical pellet. X-ray radiation ablates the surface of the pellet, imploding a thin shell of deuterium/tritium (DT) that must accelerate to high velocity (v > 350 km s-1) and compress by a factor of several thousand. Since 2009, substantial progress has been made in understanding the major challenges to ignition: Rayleigh Taylor (RT) instability seeded bymore » target imperfections; and low-mode asymmetries in the hohlraum x-ray drive, exacerbated by laser-plasma instabilities (LPI). Requirements on velocity, symmetry, and compression have been demonstrated separately on the NIF but have not been achieved simultaneously. We now know that the RT instability, seeded mainly by the capsule support tent, severely degraded DT implosions from 2009–2012. Experiments using a 'high-foot' drive with demonstrated lower RT growth improved the thermonuclear yield by a factor of 10, resulting in yield amplification due to alpha particle heating by more than a factor of 2. However, large time dependent drive asymmetry in the LPI-dominated hohlraums remains unchanged, preventing further improvements. High fidelity 3D hydrodynamic calculations explain these results. In conclusion, future research efforts focus on improved capsule mounting techniques and on hohlraums with little LPI and controllable symmetry. In parallel, we are pursuing improvements to the basic physics models used in the design codes through focused physics experiments.« less

  17. Indirect drive ignition at the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Meezan, N. B.; Edwards, M. J.; Hurricane, O. A.; Patel, P. K.; Callahan, D. A.; Hsing, W. W.; Town, R. P. J.; Albert, F.; Amendt, P. A.; Berzak Hopkins, L. F.; Bradley, D. K.; Casey, D. T.; Clark, D. S.; Dewald, E. L.; Dittrich, T. R.; Divol, L.; Döppner, T.; Field, J. E.; Haan, S. W.; Hall, G. N.; Hammel, B. A.; Hinkel, D. E.; Ho, D. D.; Hohenberger, M.; Izumi, N.; Jones, O. S.; Khan, S. F.; Kline, J. L.; Kritcher, A. L.; Landen, O. L.; LePape, S.; Ma, T.; MacKinnon, A. J.; MacPhee, A. G.; Masse, L.; Milovich, J. L.; Nikroo, A.; Pak, A.; Park, H.-S.; Peterson, J. L.; Robey, H. F.; Ross, J. S.; Salmonson, J. D.; Smalyuk, V. A.; Spears, B. K.; Stadermann, M.; Suter, L. J.; Thomas, C. A.; Tommasini, R.; Turnbull, D. P.; Weber, C. R.

    2017-01-01

    This paper reviews scientific results from the pursuit of indirect drive ignition on the National Ignition Facility (NIF) and describes the program’s forward looking research directions. In indirect drive on the NIF, laser beams heat an x-ray enclosure called a hohlraum that surrounds a spherical pellet. X-ray radiation ablates the surface of the pellet, imploding a thin shell of deuterium/tritium (DT) that must accelerate to high velocity (v  >  350 km s-1) and compress by a factor of several thousand. Since 2009, substantial progress has been made in understanding the major challenges to ignition: Rayleigh Taylor (RT) instability seeded by target imperfections; and low-mode asymmetries in the hohlraum x-ray drive, exacerbated by laser-plasma instabilities (LPI). Requirements on velocity, symmetry, and compression have been demonstrated separately on the NIF but have not been achieved simultaneously. We now know that the RT instability, seeded mainly by the capsule support tent, severely degraded DT implosions from 2009-2012. Experiments using a ‘high-foot’ drive with demonstrated lower RT growth improved the thermonuclear yield by a factor of 10, resulting in yield amplification due to alpha particle heating by more than a factor of 2. However, large time dependent drive asymmetry in the LPI-dominated hohlraums remains unchanged, preventing further improvements. High fidelity 3D hydrodynamic calculations explain these results. Future research efforts focus on improved capsule mounting techniques and on hohlraums with little LPI and controllable symmetry. In parallel, we are pursuing improvements to the basic physics models used in the design codes through focused physics experiments.

  18. Indirect drive ignition at the National Ignition Facility

    SciTech Connect

    Meezan, N. B.; Edwards, M. J.; Hurricane, O. A.; Patel, P. K.; Callahan, D. A.; Hsing, W. W.; Town, R. P. J.; Albert, F.; Amendt, P. A.; Berzak Hopkins, L. F.; Bradley, D. K.; Casey, D. T.; Clark, D. S.; Dewald, E. L.; Dittrich, T. R.; Divol, L.; Döppner, T.; Field, J. E.; Haan, S. W.; Hall, G. N.; Hammel, B. A.; Hinkel, D. E.; Ho, D. D.; Hohenberger, M.; Izumi, N.; Jones, O. S.; Khan, S. F.; Kline, J. L.; Kritcher, A. L.; Landen, O. L.; LePape, S.; Ma, T.; MacKinnon, A. J.; MacPhee, A. G.; Masse, L.; Milovich, J. L.; Nikroo, A.; Pak, A.; Park, H-S; Peterson, J. L.; Robey, H. F.; Ross, J. S.; Salmonson, J. D.; Smalyuk, V. A.; Spears, B. K.; Stadermann, M.; Suter, L. J.; Thomas, C. A.; Tommasini, R.; Turnbull, D. P.; Weber, C. R.

    2016-10-27

    This article reviews scientific results from the pursuit of indirect drive ignition on the National Ignition Facility (NIF) and describes the program's forward looking research directions. In indirect drive on the NIF, laser beams heat an x-ray enclosure called a hohlraum that surrounds a spherical pellet. X-ray radiation ablates the surface of the pellet, imploding a thin shell of deuterium/tritium (DT) that must accelerate to high velocity (v > 350 km s-1) and compress by a factor of several thousand. Since 2009, substantial progress has been made in understanding the major challenges to ignition: Rayleigh Taylor (RT) instability seeded by target imperfections; and low-mode asymmetries in the hohlraum x-ray drive, exacerbated by laser-plasma instabilities (LPI). Requirements on velocity, symmetry, and compression have been demonstrated separately on the NIF but have not been achieved simultaneously. We now know that the RT instability, seeded mainly by the capsule support tent, severely degraded DT implosions from 2009–2012. Experiments using a 'high-foot' drive with demonstrated lower RT growth improved the thermonuclear yield by a factor of 10, resulting in yield amplification due to alpha particle heating by more than a factor of 2. However, large time dependent drive asymmetry in the LPI-dominated hohlraums remains unchanged, preventing further improvements. High fidelity 3D hydrodynamic calculations explain these results. In conclusion, future research efforts focus on improved capsule mounting techniques and on hohlraums with little LPI and controllable symmetry. In parallel, we are pursuing improvements to the basic physics models used in the design codes through focused physics experiments.

  19. Adiabat-shaping in indirect drive inertial confinement fusion

    SciTech Connect

    Baker, K. L.; Robey, H. F.; Milovich, J. L.; Jones, O. S.; Smalyuk, V. A.; Casey, D. T.; MacPhee, A. G.; Pak, A.; Celliers, P. M.; Clark, D. S.; Landen, O. L.; Peterson, J. L.; Berzak-Hopkins, L. F.; Weber, C. R.; Haan, S. W.; Döppner, T. D.; Dixit, S.; Hamza, A. V.; Jancaitis, K. S.; Kroll, J. J.; and others

    2015-05-15

    Adiabat-shaping techniques were investigated in indirect drive inertial confinement fusion experiments on the National Ignition Facility as a means to improve implosion stability, while still maintaining a low adiabat in the fuel. Adiabat-shaping was accomplished in these indirect drive experiments by altering the ratio of the picket and trough energies in the laser pulse shape, thus driving a decaying first shock in the ablator. This decaying first shock is designed to place the ablation front on a high adiabat while keeping the fuel on a low adiabat. These experiments were conducted using the keyhole experimental platform for both three and four shock laser pulses. This platform enabled direct measurement of the shock velocities driven in the glow-discharge polymer capsule and in the liquid deuterium, the surrogate fuel for a DT ignition target. The measured shock velocities and radiation drive histories are compared to previous three and four shock laser pulses. This comparison indicates that in the case of adiabat shaping the ablation front initially drives a high shock velocity, and therefore, a high shock pressure and adiabat. The shock then decays as it travels through the ablator to pressures similar to the original low-adiabat pulses when it reaches the fuel. This approach takes advantage of initial high ablation velocity, which favors stability, and high-compression, which favors high stagnation pressures.

  20. The athlete's biological passport and indirect markers of blood doping.

    PubMed

    Sottas, Pierre-Edouard; Robinson, Neil; Saugy, Martial

    2010-01-01

    In the fight against doping, disciplinary sanctions have up to now been primarily based on the discovery of an exogenous substance in a biological fluid of the athlete. However, indirect markers of altered erythropoiesis can provide enough evidence to differentiate between natural variations and blood doping. Forensic techniques for the evaluation of the evidence, and more particularly Bayesian networks, allow antidoping authorities to take into account firstly the natural variations of indirect markers - through a mathematical formalism based on probabilities - and secondly the complexity due to the multiplicity of causes and confounding effects - through a distributed and flexible graphical representation. The information stored in an athlete's biological passport may be then sufficient to launch a disciplinary procedure against the athlete. The strength of the passport is that it relies on a statistical approach based on sound empirical testing on large populations and justifiable protocols. Interestingly, its introduction coincides with the paradigm shift that is materializing today in forensic identification science, from archaic assumptions of absolute certainty and perfection to a more defensible empirical and probabilistic foundation.

  1. Evaluating The Indirect Effect of Cirrus Clouds

    NASA Astrophysics Data System (ADS)

    Dobbie, S.; Jonas, P. R.

    What effect would an increase in nucleating aerosols have on the radiative and cloud properties? What error would be incurred by evaluating the indirect effect by taking an evolved cloud and fixing the integrated water content and vary the number of ice crystals? These questions will be addressed in this work. We will use the UK LES cloud resolving model to perform a sensitivity study for cirrus clouds to the indirect effect, and will evaluate approximate methods in the process. In this work, we will initialize the base (no increase of aerosol) cirrus clouds so that the double moment scheme is constrained to agree with observations through the ef- fective radius. Effective radius is calculated using the local concentration and the ice water content. We then perform a sensitivity experiment to investigate the dependence of the average IWC, effective size, and radiative properties (including heating rates) to variations in the nucleation rate. Conclusions will be draw as to the possible ef- fect of changes in aerosol amounts on cirrus. We will determine how sensitive the cloud and radiative properties are to various aerosol increases. We will also discuss the applicability of the Meyer et al. (1992) nucleation formulae for our simulations. It is important to stress that in this work we only change the nucleation rate for the newly forming cloud. By doing this, we are not fixing the total water content and redistributing the water amongst increased ice crystals. We increase the number of aerosols available to be nucleated and allow the model to evolve the size distributions. In this way, there is competition for the water vapour, the ice particles are evolved dynamically with different fall speeds, the conversion rates to other hydrometers (such as aggregates) are affected, and the heating rates are different due to the different size distributions that evolve. We will look at how the water content, the distribution of water, and the radiative properties are affected

  2. [Direct and indirect costs of schizophrenia].

    PubMed

    Kissling, W; Höffler, J; Seemann, U; Müller, P; Rüther, E; Trenckmann, U; Uber, A; Graf von der Schulenburg, J M; Glaser, P; Glaser, T; Mast, O; Schmidt, D

    1999-01-01

    In the present study the costs of schizophrenia in Germany were studied using the "bottom up" prevalence-based method. In a random sample of 180 schizophrenic patients stratified according to the most important care institutions, direct and indirect costs were retrospectively documented for a 12-month period. Depending on the place of recruitment and the extent of care provided, total yearly costs result between about DM 33,000 for a patient treated predominantly on an outpatient basis and about DM 126,000 for a patient requiring hospital care and about DM 135,000 for a patient in job rehabilitation. The direct yearly treatment costs were, as expected, lowest for patients recruited in the private practice of a psychiatrist and predominantly treated on an outpatient basis (DM 5,788), and were the highest in the psychiatric hospital (DM 64,661) and in job rehabilitation (DM 79,996). In the patients recruited in the outpatient domain, doctors' fees and medication together were responsible for only 4.5% of the total costs, whereas the indirect costs (e.g., through work incapacity) were responsible for 87% of the total yearly costs. For methodological reasons the total costs caused by schizophrenic psychoses in Germany per year can at present be estimated only roughly. A conservative estimate is between 8.5 and 18 billion DM per year. The study shows that schizophrenia is a very expensive illness, the direct and indirect costs of which are on the whole comparable to those of the common somatic illnesses. Therefore, also for economical reasons, sufficient financial means should be invested in the research and treatment of this severe illness.

  3. Alliance-focused training.

    PubMed

    Eubanks-Carter, Catherine; Muran, J Christopher; Safran, Jeremy D

    2015-06-01

    Alliance-focused training (AFT) aims to increase therapists' ability to recognize, tolerate, and negotiate alliance ruptures by increasing the therapeutic skills of self-awareness, affect regulation, and interpersonal sensitivity. In AFT, therapists are encouraged to draw on these skills when metacommunicating about ruptures with patients. In this article, we present the 3 main supervisory tasks of AFT: videotape analysis of rupture moments, awareness-oriented role-plays, and mindfulness training. We describe the theoretical and empirical support for each supervisory task, provide examples based on actual supervision sessions, and present feedback about the usefulness of the techniques from trainees in our program. We also note some of the challenges involved in conducting AFT and the importance of maintaining a strong supervisory alliance when using this training approach.

  4. Focus awards 2002.

    PubMed

    Davis, Naomi

    2003-03-22

    The dental team at Zetland House Clinic are a particularly innovative group. As a result of their parent hospital being the first to complete a whole organization clinical governance programme run by the NHS Modernization Agency, they were consequently the first dental team to do so. Now the clinic is a better place to work where the staff are proud of their clinic and the work that they do. The changes that resulted through their experiences of the program have benefited the patients and staff alike, and was such a success story that they have been taken as an example for the Modernisation Agency website to illustrate good practice in clinical governance. These changes and the way they approached their involvement in the program also earned the Zetland House team a place on the finalist list of the 2002 Focus Awards.

  5. Indirect Dietary Residential Exposure Assessment Model (IDREAM) Implementation

    EPA Pesticide Factsheets

    The Indirect Dietary Residential Exposure Assessment Model (IDREAM) estimates indirect ingestion exposure to disinfectants used in residential settings on hard surfaces where there may be inadvertent transfer to edible items prepared on those surfaces.

  6. Focusing on customer service.

    PubMed

    1996-01-01

    This booklet is devoted to a consideration of how good customer service in family planning programs can generate demand for products and services, bring customers back, and reduce costs. Customer service is defined as increasing client satisfaction through continuous concern for client preferences, staff accountability to clients, and respect for the rights of clients. Issues discussed include the introduction of a customer service approach and gaining staff commitment. The experience of PROSALUD in Bolivia in recruiting appropriate staff, supervising staff, soliciting client feedback, and marketing services is offered as an example of a successful customer service approach. The key customer service functions are described as 1) establishing a welcoming atmosphere, 2) streamlining client flow, 3) personalizing client services, and 4) organizing and providing clear information to clients. The role of the manager in developing procedures is explored, and the COPE (Client-Oriented Provider-Efficient) process is presented as a good way to begin to make improvements. Techniques in staff training in customer service include brainstorming, role playing, using case studies (examples of which are provided), and engaging in practice sessions. Training also leads to the development of effective customer service attitudes, and the differences between these and organizational/staff-focused attitudes are illustrated in a chart. The use of communication skills (asking open-ended questions, helping clients express their concerns, engaging in active listening, and handling difficult situations) is considered. Good recovery skills are important when things go wrong. Gathering and using client feedback is the next topic considered. This involves identifying, recording, and discussing customer service issues as well as taking action on these issues and evaluating the results. The booklet ends by providing a sample of customer service indicators, considering the maintenance of a

  7. "Only" and Focus.

    ERIC Educational Resources Information Center

    Vallduvi, Enric

    The relationship of the word "only," one of a class of words known as scalar particles, focus adverbs, focus inducers, or focus-sensitive particles, with the "focus" of the sentence is examined. It is suggested, based on analysis of discourse structure, that this "association with focus" is not an inherent property of…

  8. Plutonium focus area: Technology summary

    SciTech Connect

    1996-03-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this approach, EM developed a management structure and principles that led to creation of specific focus areas. These organizations were designed to focus scientific and technical talent throughout DOE and the national scientific community on major environmental restoration and waste management problems facing DOE. The focus area approach provides the framework for inter-site cooperation and leveraging of resources on common problems. After the original establishment of five major focus areas within the Office of Technology Development (EM-50), the Nuclear Materials Stabilization Task Group (NMSTG, EM-66) followed EM-50`s structure and chartered the Plutonium Focus Area (PFA). NMSTG`s charter to the PFA, described in detail later in this book, plays a major role in meeting the EM-66 commitments to the Defense Nuclear Facilities Safety Board (DNFSB). The PFA is a new program for FY96 and as such, the primary focus of revision 0 of this Technology Summary is an introduction to the Focus Area; its history, development, and management structure, including summaries of selected technologies being developed. Revision 1 to the Plutonium Focus Area Technology Summary is slated to include details on all technologies being developed, and is currently planned for release in August 1996. The following report outlines the scope and mission of the Office of Environmental Management, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  9. Indirect genomic effects on survival from gene expression data

    PubMed Central

    Ferkingstad, Egil; Frigessi, Arnoldo; Lyng, Heidi

    2008-01-01

    In cancer, genes may have indirect effects on patient survival, mediated through interactions with other genes. Methods to study the indirect effects that contribute significantly to survival are not available. We propose a novel methodology to detect and quantify indirect effects from gene expression data. We discover indirect effects through several target genes of transcription factors in cancer microarray data, pointing to genetic interactions that play a significant role in tumor progression. PMID:18358079

  10. 49 CFR 30.9 - Citizenship: Direct or indirect control.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Citizenship: Direct or indirect control. 30.9... Citizenship: Direct or indirect control. A contractor, subcontractor, or person providing a service shall be considered to be a citizen or national of a foreign country, or controlled directly or indirectly by...

  11. 23 CFR 140.907 - Overhead and indirect construction costs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... which assure proper control and distribution of the overhead and indirect construction costs. ... 23 Highways 1 2012-04-01 2012-04-01 false Overhead and indirect construction costs. 140.907... REIMBURSEMENT Reimbursement for Railroad Work § 140.907 Overhead and indirect construction costs. (a) A...

  12. 48 CFR 1342.703-2 - Certificate of indirect costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... costs. 1342.703-2 Section 1342.703-2 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 1342.703-2 Certificate of indirect costs... indirect cost rates is set forth in CAM 1301.70....

  13. 48 CFR 742.770 - Negotiated indirect cost rate agreement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Negotiated indirect cost rate agreement. 742.770 Section 742.770 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 742.770 Negotiated indirect...

  14. 48 CFR 3442.705 - Final indirect cost rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Final indirect cost rates. 3442.705 Section 3442.705 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 3442.705 Final indirect cost...

  15. 48 CFR 1542.705 - Final indirect cost rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Final indirect cost rates. 1542.705 Section 1542.705 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 1542.705 Final indirect cost rates. (a)...

  16. 21 CFR 870.3640 - Indirect pacemaker generator function analyzer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Indirect pacemaker generator function analyzer. 870.3640 Section 870.3640 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Indirect pacemaker generator function analyzer. (a) Identification. An indirect pacemaker...

  17. 21 CFR 870.3640 - Indirect pacemaker generator function analyzer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Indirect pacemaker generator function analyzer. 870.3640 Section 870.3640 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Indirect pacemaker generator function analyzer. (a) Identification. An indirect pacemaker...

  18. 21 CFR 870.3640 - Indirect pacemaker generator function analyzer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Indirect pacemaker generator function analyzer. 870.3640 Section 870.3640 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Indirect pacemaker generator function analyzer. (a) Identification. An indirect pacemaker...

  19. 21 CFR 870.3640 - Indirect pacemaker generator function analyzer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Indirect pacemaker generator function analyzer. 870.3640 Section 870.3640 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Indirect pacemaker generator function analyzer. (a) Identification. An indirect pacemaker...

  20. 21 CFR 870.3640 - Indirect pacemaker generator function analyzer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Indirect pacemaker generator function analyzer. 870.3640 Section 870.3640 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Indirect pacemaker generator function analyzer. (a) Identification. An indirect pacemaker...

  1. Effect of private information on indirect reciprocity.

    PubMed

    Uchida, Satoshi

    2010-09-01

    Indirect reciprocity is one of the key mechanisms for the evolution of cooperation. It relies on mutual monitoring and assessments, i.e., individuals collect information about the past behavior of others and judge whether that behavior is "good" or "bad." A player will not be helped if labeled with a bad image. There are many ways for assessing others, each of which can be interpreted as an elementary form of a moral sense (i.e., a view on what is good or bad). The information can be either public or private: private information can lead to mismatches between the opinions of individuals even when they share the same moral sense. In this paper, the effect of private information on the best-known assessment rules is investigated. In order to calculate payoffs, the concept of an image matrix is introduced. It describes who is good in the eyes of whom, and its time evolution is given by a probabilistic Boolean automaton. In contrast to the public information case, private information leads to the collapse of the sterner assessment rule. Alternatively, stable polymorphisms may subsist, with the milder rule and a more simple-minded rule coexisting together with unconditional cooperators; thus, cooperation can be sustained by indirect reciprocity even in the absence of public information.

  2. Effect of private information on indirect reciprocity

    NASA Astrophysics Data System (ADS)

    Uchida, Satoshi

    2010-09-01

    Indirect reciprocity is one of the key mechanisms for the evolution of cooperation. It relies on mutual monitoring and assessments, i.e., individuals collect information about the past behavior of others and judge whether that behavior is “good” or “bad.” A player will not be helped if labeled with a bad image. There are many ways for assessing others, each of which can be interpreted as an elementary form of a moral sense (i.e., a view on what is good or bad). The information can be either public or private: private information can lead to mismatches between the opinions of individuals even when they share the same moral sense. In this paper, the effect of private information on the best-known assessment rules is investigated. In order to calculate payoffs, the concept of an image matrix is introduced. It describes who is good in the eyes of whom, and its time evolution is given by a probabilistic Boolean automaton. In contrast to the public information case, private information leads to the collapse of the sterner assessment rule. Alternatively, stable polymorphisms may subsist, with the milder rule and a more simple-minded rule coexisting together with unconditional cooperators; thus, cooperation can be sustained by indirect reciprocity even in the absence of public information.

  3. Evolutionary indirect effects of biological invasions.

    PubMed

    Lau, Jennifer A

    2012-09-01

    Just as ecological indirect effects can have a wide range of consequences for community structure and ecosystem function, theory suggests that evolutionary indirect effects can also influence community dynamics and the outcome of species interactions. There is little empirical evidence documenting such effects, however. Here, I use a multi-generation selection experiment in the field to investigate: (1) how the exotic plant Medicago polymorpha and the exotic insect herbivore Hypera brunneipennis affect the evolution of anti-herbivore resistance traits in the native plant Lotus wrangelianus and (2) how observed Lotus evolutionary responses to Hypera alter interactions between Lotus and other members of the herbivore community. In one of two study populations, I document rapid evolutionary changes in Lotus resistance to Hypera in response to insecticide treatments that experimentally reduced Hypera abundance, and in response to Medicago-removal treatments that also reduced Hypera abundance. These evolutionary changes in response to Hypera result in reduced attack by aphids. Thus, an evolutionary change caused by one herbivore species alters interactions with other herbivore taxa, an example of an eco-evolutionary feedback. Given that many traits mediate interactions with multiple species, the effects of evolutionary changes in response to one key biotic selective agent may often cascade through interaction webs to influence additional community members.

  4. Cooperation under Indirect Reciprocity and Imitative Trust

    PubMed Central

    Saavedra, Serguei; Smith, David; Reed-Tsochas, Felix

    2010-01-01

    Indirect reciprocity, a key concept in behavioral experiments and evolutionary game theory, provides a mechanism that allows reciprocal altruism to emerge in a population of self-regarding individuals even when repeated interactions between pairs of actors are unlikely. Recent empirical evidence show that humans typically follow complex assessment strategies involving both reciprocity and social imitation when making cooperative decisions. However, currently, we have no systematic understanding of how imitation, a mechanism that may also generate negative effects via a process of cumulative advantage, affects cooperation when repeated interactions are unlikely or information about a recipient's reputation is unavailable. Here we extend existing evolutionary models, which use an image score for reputation to track how individuals cooperate by contributing resources, by introducing a new imitative-trust score, which tracks whether actors have been the recipients of cooperation in the past. We show that imitative trust can co-exist with indirect reciprocity mechanisms up to a threshold and then cooperation reverses -revealing the elusive nature of cooperation. Moreover, we find that when information about a recipient's reputation is limited, trusting the action of third parties towards her (i.e. imitating) does favor a higher collective cooperation compared to random-trusting and share-alike mechanisms. We believe these results shed new light on the factors favoring social imitation as an adaptive mechanism in populations of cooperating social actors. PMID:21048950

  5. Surface-modified complex SU-8 microstructures for indirect optical manipulation of single cells

    PubMed Central

    Aekbote, Badri L.; Fekete, Tamás; Jacak, Jaroslaw; Vizsnyiczai, Gaszton; Ormos, Pál; Kelemen, Lóránd

    2015-01-01

    We introduce a method that combines two-photon polymerization (TPP) and surface functionalization to enable the indirect optical manipulation of live cells. TPP-made 3D microstructures were coated specifically with a multilayer of the protein streptavidin and non-specifically with IgG antibody using polyethylene glycol diamine as a linker molecule. Protein density on their surfaces was quantified for various coating methods. The streptavidin-coated structures were shown to attach to biotinated cells reproducibly. We performed basic indirect optical micromanipulation tasks with attached structure-cell couples using complex structures and a multi-focus optical trap. The use of such extended manipulators for indirect optical trapping ensures to keep a safe distance between the trapping beams and the sensitive cell and enables their 6 degrees of freedom actuation. PMID:26819816

  6. Indirect measurements of nuclear astrophysics reactions at CIAE

    SciTech Connect

    Liu Weiping; Li Zhihong; Bai Xixiang; Wang Youbao; Lian Gang; Guo Bing; Zeng Sheng; Yan Shengquan; Wang Baoxiang; Su Jun; Shu Nengchuan; Chen Yongshou

    2006-11-02

    This paper described the nuclear astrophysical studies using the unstable ion beam facility GIRAFFE, by indirect measurements. We measured the angular distributions for some single proton or neutron transfer reactions, such as 7Be(d,n)8B, 11C(d,n)12N, 8Li(d,n)9Be, 8Li(d,p)9Li and 13N(d,n)14O in inverse kinematics, and derived the astrophysical S-factors or reaction rates of 7Be(p,{gamma})8B, 11C(p,{gamma})12N, 8Li(n,{gamma})9Li, 13N(p,{gamma})14O by asymptotic normalization coefficient, spectroscopic factor, and R-matrix approach at astrophysically relevant energies.

  7. AXAF SIM focus mechanism study

    NASA Astrophysics Data System (ADS)

    Tananbaum, H. D.; Whitbeck, E.

    1994-02-01

    is by counting motor steps. The 'backup' method is by a pot mounted on the drive ring. Neither method provides for a direct measurement of the quantity desired (focus position). This is of concern because of the long and indirect relationship between focus and the sensed quantity (drive ring rotation). There are three sinusoidal relationships and structural stiffness in the path, and the resulting calibration is likely to be highly nonlinear. These methods would require an accurate ground calibration. (3) Ground calibration (and verification) of focus vs. drive position must be done in 1-g on the ground. This calibration will be complicated by both the structural characteristics of the bipods and the fact that the CG of the translating portion of the SIM is not on the optical axis (thereby causing unwanted rotations and changing the focus position vs. motor step and pot readout relationships). focus position sensor is questionable in terms of reliability for a five year mission. The results of SAO's study of items 1, 2 and 3 described above are presented in this report.

  8. Cruel Intentions on Television and in Real Life: Can Viewing Indirect Aggression Increase Viewers' Subsequent Indirect Aggression?

    ERIC Educational Resources Information Center

    Coyne, Sarah M.; Archer, John; Eslea, Mike

    2004-01-01

    Numerous studies have shown that viewing violence in the media can influence an individual's subsequent aggression, but none have examined the effect of viewing indirect aggression. This study examines the immediate effect of viewing indirect and direct aggression on subsequent indirect aggression among 199 children ages 11 to 14 years. They were…

  9. On the characteristics of aerosol indirect effect based on dynamic regimes in global climate models

    NASA Astrophysics Data System (ADS)

    Zhang, Shipeng; Wang, Minghuai; Ghan, Steven J.; Ding, Aijun; Wang, Hailong; Zhang, Kai; Neubauer, David; Lohmann, Ulrike; Ferrachat, Sylvaine; Takeamura, Toshihiko; Gettelman, Andrew; Morrison, Hugh; Lee, Yunha; Shindell, Drew T.; Partridge, Daniel G.; Stier, Philip; Kipling, Zak; Fu, Congbin

    2016-03-01

    Aerosol-cloud interactions continue to constitute a major source of uncertainty for the estimate of climate radiative forcing. The variation of aerosol indirect effects (AIE) in climate models is investigated across different dynamical regimes, determined by monthly mean 500 hPa vertical pressure velocity (ω500), lower-tropospheric stability (LTS) and large-scale surface precipitation rate derived from several global climate models (GCMs), with a focus on liquid water path (LWP) response to cloud condensation nuclei (CCN) concentrations. The LWP sensitivity to aerosol perturbation within dynamic regimes is found to exhibit a large spread among these GCMs. It is in regimes of strong large-scale ascent (ω500 < -25 hPa day-1) and low clouds (stratocumulus and trade wind cumulus) where the models differ most. Shortwave aerosol indirect forcing is also found to differ significantly among different regimes. Shortwave aerosol indirect forcing in ascending regimes is close to that in subsidence regimes, which indicates that regimes with strong large-scale ascent are as important as stratocumulus regimes in studying AIE. It is further shown that shortwave aerosol indirect forcing over regions with high monthly large-scale surface precipitation rate (> 0.1 mm day-1) contributes the most to the total aerosol indirect forcing (from 64 to nearly 100 %). Results show that the uncertainty in AIE is even larger within specific dynamical regimes compared to the uncertainty in its global mean values, pointing to the need to reduce the uncertainty in AIE in different dynamical regimes.

  10. On the characteristics of aerosol indirect effect based on dynamic regimes in global climate models

    SciTech Connect

    Zhang, S.; Wang, Minghuai; Ghan, Steven J.; Ding, A.; Wang, Hailong; Zhang, Kai; Neubauer, David; Lohmann, U.; Ferrachat, S.; Takeamura, Toshihiko; Gettelman, A.; Morrison, H.; Lee, Y. H.; Shindell, D. T.; Partridge, Daniel; Stier, P.; Kipling, Z.; Fu, Congbin

    2016-03-04

    Aerosol-cloud interactions continue to constitute a major source of uncertainty for the estimate of climate radiative forcing. The variation of aerosol indirect effects (AIE) in climate models is investigated across different dynamical regimes, determined by monthly mean 500 hPa vertical pressure velocity (ω500), lower-tropospheric stability (LTS) and large-scale surface precipitation rate derived from several global climate models (GCMs), with a focus on liquid water path (LWP) response to cloud condensation nuclei (CCN) concentrations. The LWP sensitivity to aerosol perturbation within dynamic regimes is found to exhibit a large spread among these GCMs. It is in regimes of strong large-scale ascend (ω500 < -25 hPa/d) and low clouds (stratocumulus and trade wind cumulus) where the models differ most. Shortwave aerosol indirect forcing is also found to differ significantly among different regimes. Shortwave aerosol indirect forcing in ascending regimes is as large as that in stratocumulus regimes, which indicates that regimes with strong large-scale ascend are as important as stratocumulus regimes in studying AIE. 42" It is further shown that shortwave aerosol indirect forcing over regions with high monthly large-scale surface precipitation rate (> 0.1 mm/d) contributes the most to the total aerosol indirect forcing (from 64% to nearly 100%). Results show that the uncertainty in AIE is even larger within specific dynamical regimes than that globally, pointing to the need to reduce the uncertainty in AIE in different dynamical regimes.

  11. Organizing for Schooling. IDRA Focus.

    ERIC Educational Resources Information Center

    IDRA Newsletter, 1996

    1996-01-01

    This newsletter focuses on schoolwide approaches to issues of major concern to educators, from the perspective of providing equal education for all children. "Supporting School Improvement in Reading through Professional Development" (Rogelio Lopez del Bosque, Abelardo Villarreal) describes a professional development program that…

  12. Remote Leak Detection: Indirect Thermal Technique

    NASA Technical Reports Server (NTRS)

    Clements, Sandra

    2002-01-01

    Remote sensing technologies are being considered for efficient, low cost gas leak detection. Eleven specific techniques have been identified for further study and evaluation of several of these is underway. The Indirect Thermal Technique is one of the techniques that is being explored. For this technique, an infrared camera is used to detect the temperature change of a pipe or fitting at the site of a gas leak. This temperature change is caused by the change in temperature of the gas expanding from the leak site. During the 10-week NFFP program, the theory behind the technique was further developed, experiments were performed to determine the conditions for which the technique might be viable, and a proof-of-concept system was developed and tested in the laboratory.

  13. Indirect evaporative coolers with enhanced heat transfer

    DOEpatents

    Kozubal, Eric; Woods, Jason; Judkoff, Ron

    2015-09-22

    A separator plate assembly for use in an indirect evaporative cooler (IEC) with an air-to-air heat exchanger. The assembly includes a separator plate with a first surface defining a dry channel and a second surface defining a wet channel. The assembly includes heat transfer enhancements provided on the first surface for increasing heat transfer rates. The heat transfer enhancements may include slit fins with bodies extending outward from the first surface of separator plate or may take other forms including vortex generators, offset strip fins, and wavy fins. In slit fin implementations, the separator plate has holes proximate to each of the slit fins, and the separator plate assembly may include a sealing layer applied to the second surface of the separator plate to block air flow through the holes. The sealing layer can be a thickness of adhesive, and a layer of wicking material is applied to the adhesive.

  14. Organic waste destruction by indirect electrooxidation

    SciTech Connect

    Leffrang, U.; Ebert, K.; Flory, K.

    1995-04-01

    The destruction of organic model substances by indirect electrooxidation was investigated. The oxidation agent Co(III) was used because of the high redox potential of the Co(III)/Co(II) redox couple (E{sub O}=1.808 V). Experiments were performed in a batch and in a continuous electrolytic cell by using various model substances (especially phenol and different chlorophenols). Intermediate and final products of the oxidation were identified and quantified. Organic carbon is ultimately transformed to CO{sub 2} and to small amounts of CO. The residual carbon in the process solution was determined by TOC measurement to be about 20 ppm. Organic chlorine is oxidized via chlorate to perchlorate. The remaining amount of adsorbable organic halogens (AOX) was less than 3 ppm. Based on these results, a pilot plant was constructed and is presently in operation.

  15. The indirect binary n-cube array

    NASA Technical Reports Server (NTRS)

    Pease, M. C.

    1977-01-01

    The array is built from a large number (hundreds or thousands) of microprocessors or microcomputers linked through a switching network into an indirect binary n-cube array. Control is two level, the array operating synchronously, or in lock step, at the higher level, and with the broadcast commands being locally interpreted into rewritable microinstruction streams in the microprocessors and in the switch control units. The key to the design is the switching array. By properly programming it, the array can be made into a wide variety of virtual arrays which are well adapted to a wide range of applications. It is believed that the flexibility of the switching array can be used to obtain fault avoidance, which appears necessary in any highly parallel design.

  16. Aerosol indirect effects ? general circulation model intercomparison and evaluation with satellite data

    SciTech Connect

    Quaas, Johannes; Ming, Yi; Menon, Surabi; Takemura, Toshihiko; Wang, Minghuai; Penner, Joyce E.; Gettelman, Andrew; Lohmann, Ulrike; Bellouin, Nicolas; Boucher, Olivier; Sayer, Andrew M.; Thomas, Gareth E.; McComiskey, Allison; Feingold, Graham; Hoose, Corinna; Kristansson, Jon Egill; Liu, Xiaohong; Balkanski, Yves; Donner, Leo J.; Ginoux, Paul A.; Stier, Philip; Grandey, Benjamin; Feichter, Johann; Sednev, Igor; Bauer, Susanne E.; Koch, Dorothy; Grainger, Roy G.; Kirkevag, Alf; Iversen, Trond; Seland, Oyvind; Easter, Richard; Ghan, Steven J.; Rasch, Philip J.; Morrison, Hugh; Lamarque, Jean-Francois; Iacono, Michael J.; Kinne, Stefan; Schulz, Michael

    2010-03-12

    Aerosol indirect effects continue to constitute one of the most important uncertainties for anthropogenic climate perturbations. Within the international AEROCOM initiative, the representation of aerosol-cloud-radiation interactions in ten different general circulation models (GCMs) is evaluated using three satellite datasets. The focus is on stratiform liquid water clouds since most GCMs do not include ice nucleation effects, and none of the model explicitly parameterises aerosol effects on convective clouds. We compute statistical relationships between aerosol optical depth ({tau}{sub a}) and various cloud and radiation quantities in a manner that is consistent between the models and the satellite data. It is found that the model-simulated influence of aerosols on cloud droplet number concentration (N{sub d}) compares relatively well to the satellite data at least over the ocean. The relationship between {tau}{sub a} and liquid water path is simulated much too strongly by the models. This suggests that the implementation of the second aerosol indirect effect mainly in terms of an autoconversion parameterisation has to be revisited in the GCMs. A positive relationship between total cloud fraction (f{sub cld}) and {tau}{sub a} as found in the satellite data is simulated by the majority of the models, albeit less strongly than that in the satellite data in most of them. In a discussion of the hypotheses proposed in the literature to explain the satellite-derived strong f{sub cld} - {tau}{sub a} relationship, our results indicate that none can be identified as a unique explanation. Relationships similar to the ones found in satellite data between {tau}{sub a} and cloud top temperature or outgoing long-wave radiation (OLR) are simulated by only a few GCMs. The GCMs that simulate a negative OLR - {tau}{sub a} relationship show a strong positive correlation between {tau}{sub a} and f{sub cld} The short-wave total aerosol radiative forcing as simulated by the GCMs is

  17. Promotion of cooperation in social dilemma games via generalised indirect reciprocity

    NASA Astrophysics Data System (ADS)

    Chiong, Raymond; Kirley, Michael

    2015-10-01

    This paper presents a novel generalised indirect reciprocity approach for promoting cooperation in social dilemma games. Here, players decide upon an action to play in the game based on public information (or "external cues") rather than individual-specific information. The public information is constantly updated according to the underlying learning model. Comprehensive simulation experiments using the N-player Prisoner's Dilemma (PD) and Snowdrift (SD) games show that generalised indirect reciprocity promotes high levels of cooperation across a wide range of conditions. This is despite the fact that the make-up of player groups is continually changing. As expected, the extent of cooperative behaviour observed in the "constraint-relaxed" N-player SD game is significantly higher than the N-player PD game. Our proposed generalised indirect reciprocity model may shed light on the conundrum of cooperation between anonymous individuals.

  18. Swelling behavior detection of irradiated U-10Zr alloy fuel using indirect neutron radiography

    NASA Astrophysics Data System (ADS)

    Sun, Yong; Huo, He-yong; Wu, Yang; Li, Jiangbo; Zhou, Wei; Guo, Hai-bing; Li, Hang; Cao, Chao; Yin, Wei; Wang, Sheng; Liu, Bin; Feng, Qi-jie; Tang, Bin

    2016-11-01

    It is hopeful that fusion-fission hybrid energy system will become an effective approach to achieve long-term sustainable development of fission energy. U-10Zr alloy (which means the mass ratio of Zr is 10%) fuel is the key material of subcritical blanket for fusion-fission hybrid energy system which the irradiation performance need to be considered. Indirect neutron radiography is used to detect the irradiated U-10Zr alloy because of the high residual dose in this paper. Different burnup samples (0.1%, 0.3%, 0.5% and 0.7%) have been tested with a special indirect neutron radiography device at CMRR (China Mianyang Research Reactor). The resolution of the device is better than 50 μm and the quantitative analysis of swelling behaviors was carried out. The results show that the swelling behaviors relate well to burnup character which can be detected accurately by indirect neutron radiography.

  19. Isoelectric focusing in a drop.

    PubMed

    Weiss, Noah G; Hayes, Mark A; Garcia, Antonio A; Ansari, Rafat R

    2011-01-04

    A novel approach to molecular separations is investigated using a technique termed droplet-based isoelectric focusing. Drops are manipulated discretely on a superhydrophobic surface, subjected to low voltages for isoelectric focusing, and split-resulting in a preparative separation. A universal indicator dye demonstrates the generation of stable, reversible pH gradients (3-10) in ampholyte buffers, and these gradients lead to protein focusing within the drop length. Focusing was visually characterized, spectroscopically verified, and assessed quantitatively by noninvasive light scattering measurements. It was found to correlate with a quantitative model based on 1D steady-state theory. This work illustrates that molecular separations can be deployed within a single open drop, and the differential fractions can be separated into new discrete liquid elements.

  20. Focus on Form: A Critical Review

    ERIC Educational Resources Information Center

    Ellis, Rod

    2016-01-01

    "Focus on form" (FonF) is a central construct in task-based language teaching. The term was first introduced by Michael Long to refer to an approach where learners' attention is attracted to linguistic forms as they engage in the performance of tasks. It contrasts with a structure-based approach--"focus on forms" (FonFs)--where…

  1. Broadband geodesic pulses for three spin systems: time-optimal realization of effective trilinear coupling terms and indirect SWAP gates.

    PubMed

    Reiss, Timo O; Khaneja, Navin; Glaser, Steffen J

    2003-11-01

    Broadband implementations of time-optimal geodesic pulse elements are introduced for the efficient creation of effective trilinear coupling terms for spin systems consisting of three weakly coupled spins 1/2. Based on these pulse elements, the time-optimal implementation of indirect SWAP operations is demonstrated experimentally. The duration of indirect SWAP gates based on broadband geodesic sequence is reduced by 42.3% compared to conventional approaches.

  2. Focus Curriculum Manual; A Focus Dissemination Project.

    ERIC Educational Resources Information Center

    Human Resource Associates, Inc., Hastings, Minn.

    This training manual is for use in preparing staff members to use the Focus Model, which is a "school within a school" for disaffected high school students. The material is designed to be used as a resource aid following participation in an in-service workshop. Information is presented to help implement a contracting system to establish…

  3. A peculiar variety of indirect inguinal hernia (juxtacordal indirect inguinal hernia)

    PubMed Central

    Alkhateeb, Harith M.; Aljanabi, Thaer J.

    2015-01-01

    Background Indirect inguinal hernias are usually congenital, forming a sac in the core of the spermatic cord covered by the internal spermatic, cremasteric, and external spermatic fasciae1−3. Direct inguinal hernias are acquired; the sac lies beside/behind the cord1−3. A rare third type is a combination of indirect and direct sacs on both sides of inferior epigastric vessels1−3. We describe a rare fourth type, juxtacordal indirect oblique inguinal hernia (Fig. 1), in which the sac emerges through a weakness in the deep inguinal ring, lateral to inferior epigastric vessels, and passes into the inguinal canal beside and in contact with the cord but outside of its covering fasciae. Objective Describes a very rare variety of inguinal hernia. Design Case reports. Setting Tikrit Teaching Hospital/Salahuddin/Iraq. Participants: and presentation The first case; a 5-year-old male with right inguinal hernia, the second case; a 25-year-old man with right inguinal hernia, the third case; a 60-year-old man with right inguinal hernia. Interventions Surgery has been done electively for all. Results and discussion Because the sac emerges through the deep inguinal ring and passes through the inguinal canal, it is an indirect type and because it passes beside the spermatic cord we call it juxtacordal hernia. Because of the thick extraperitoneal fat layer over the sac, we think this hernia is acquired. Conclusions Knowing this type of hernia might reduce the risk of inferior epigastric vessels injury and lower the rate of recurrence. PMID:26052435

  4. Focus Intonation in Bengali

    ERIC Educational Resources Information Center

    Hasan, Md. Kamrul

    2015-01-01

    This work attempts to investigate the role of prosody in the syntax of focus in Bangla. The aim of this study is to show the intonation pattern of Bangla in emphasis and focus. In order to do that, the author has looked at the pattern of focus without-i/o as well as with the same. Do they really pose any different focus intonation pattern from…

  5. Direct versus Indirect Explicit Methods of Enhancing EFL Students' English Grammatical Competence: A Concept Checking-Based Consciousness-Raising Tasks Model

    ERIC Educational Resources Information Center

    Dang, Trang Thi Doan; Nguyen, Huong Thu

    2013-01-01

    Two approaches to grammar instruction are often discussed in the ESL literature: direct explicit grammar instruction (DEGI) (deduction) and indirect explicit grammar instruction (IEGI) (induction). This study aims to explore the effects of indirect explicit grammar instruction on EFL learners' mastery of English tenses. Ninety-four…

  6. Direct and indirect punishment among strangers in the field.

    PubMed

    Balafoutas, Loukas; Nikiforakis, Nikos; Rockenbach, Bettina

    2014-11-11

    Many interactions in modern human societies are among strangers. Explaining cooperation in such interactions is challenging. The two most prominent explanations critically depend on individuals' willingness to punish defectors: In models of direct punishment, individuals punish antisocial behavior at a personal cost, whereas in models of indirect reciprocity, they punish indirectly by withholding rewards. We investigate these competing explanations in a field experiment with real-life interactions among strangers. We find clear evidence of both direct and indirect punishment. Direct punishment is not rewarded by strangers and, in line with models of indirect reciprocity, is crowded out by indirect punishment opportunities. The existence of direct and indirect punishment in daily life indicates the importance of both means for understanding the evolution of cooperation.

  7. Alternating phase focused linacs

    DOEpatents

    Swenson, Donald A.

    1980-01-01

    A heavy particle linear accelerator employing rf fields for transverse and ongitudinal focusing as well as acceleration. Drift tube length and gap positions in a standing wave drift tube loaded structure are arranged so that particles are subject to acceleration and succession of focusing and defocusing forces which contain the beam without additional magnetic or electric focusing fields.

  8. Direct and indirect responses of a freshwater food web to a potent synthetic oestrogen

    PubMed Central

    Kidd, Karen A.; Paterson, Michael J.; Rennie, Michael D.; Podemski, Cheryl L.; Findlay, Dave L.; Blanchfield, Paul J.; Liber, Karsten

    2014-01-01

    Endocrine-disrupting chemicals (EDCs) in municipal effluents directly affect the sexual development and reproductive success of fishes, but indirect effects on invertebrate prey or fish predators through reduced predation or prey availability, respectively, are unknown. At the Experimental Lakes Area in northwestern Ontario, Canada, a long-term, whole-lake experiment was conducted using a before-after-control-impact design to determine both direct and indirect effects of the synthetic oestrogen used in the birth control pill, 17α-ethynyloestradiol (EE2). Algal, microbial, zooplankton and benthic invertebrate communities showed no declines in abundance during three summers of EE2 additions (5–6 ng l−1), indicating no direct toxic effects. Recruitment of fathead minnow (Pimephales promelas) failed, leading to a near-extirpation of this species both 2 years during (young-of-year, YOY) and 2 years following (adults and YOY) EE2 additions. Body condition of male lake trout (Salvelinus namaycush) and male and female white sucker (Catostomus commersonii) declined before changes in prey abundance, suggesting direct effects of EE2 on this endpoint. Evidence of indirect effects of EE2 was also observed. Increases in zooplankton, Chaoborus, and emerging insects were observed after 2 or 3 years of EE2 additions, strongly suggesting indirect effects mediated through the reduced abundance of several small-bodied fishes. Biomass of top predator lake trout declined by 23–42% during and after EE2 additions, most probably an indirect effect from the loss of its prey species, the fathead minnow and slimy sculpin (Cottus cognatus). Our results demonstrate that small-scale studies focusing solely on direct effects are likely to underestimate the true environmental impacts of oestrogens in municipal wastewaters and provide further evidence of the value of whole-ecosystem experiments for understanding indirect effects of EDCs and other aquatic stressors. PMID:25405967

  9. Exposure-response modeling of clinical end points using latent variable indirect response models.

    PubMed

    Hu, C

    2014-06-04

    Exposure-response modeling facilitates effective dosing regimen selection in clinical drug development, where the end points are often disease scores and not physiological variables. Appropriate models need to be consistent with pharmacology and identifiable from the time courses of available data. This article describes a general framework of applying mechanism-based models to various types of clinical end points. Placebo and drug model parameterization, interpretation, and assessment are discussed with a focus on the indirect response models.

  10. An indirect sensing technique for diesel fuel quantity control. Progress report, April 1--June 30, 1998

    SciTech Connect

    MacCarley, C.A.

    1998-08-31

    This reports on a project to develop an indirect sensing technique for diesel fuel quantity control. Development has continued on a vehicle-installed prototype for EPA certification and demonstration. Focus of development is on the use of this technology for retrofitting existing diesel vehicles to reduce emissions rather than exclusively upon deployment in the OEM market. Technical obstacles that have been encountered and their solutions and remaining project tasks are described.

  11. Exposure–Response Modeling of Clinical End Points Using Latent Variable Indirect Response Models

    PubMed Central

    Hu, C

    2014-01-01

    Exposure–response modeling facilitates effective dosing regimen selection in clinical drug development, where the end points are often disease scores and not physiological variables. Appropriate models need to be consistent with pharmacology and identifiable from the time courses of available data. This article describes a general framework of applying mechanism-based models to various types of clinical end points. Placebo and drug model parameterization, interpretation, and assessment are discussed with a focus on the indirect response models. PMID:24897307

  12. Establishment of indirect immunofluorescence assay for rotavirus.

    PubMed

    Tao, J; Zhang, J; Liu, X; Jin, H; Jiang, C; Yin, Y

    2016-03-01

    Rotavirus infection is the most frequent cause of infantile gastroenteritis worldwide and a significant cause of death in infants and young children, following severe diarrhea and dehydration. Rotavirus vaccines are considered the most effective way to prevent rotavirus infections. In the process of developing rotavirus vaccines, it is crucial to establish a reliable and standardized method to determine vaccine titer. In this study, we developed an indirect immunofluorescence assay (IFA) to determine the infectious titer of Lanzhou lamb rotavirus (LLR) vaccine grown in MA104 cells. The activating concentration of trypsin was 1 µg/ml for healthy monolayers of MA104 cells at 100% confluence. After incubation for 18 hr, a rabbit anti-SA11 polyclonal antibody, diluted at 1:800 in PBS, was added to all wells, followed by an Alexa-488-conjugated secondary antibody diluted at 1:500 in PBS. Cells were examined with a fluorescence microscope. Our results show that IFA was more reproducible, more sensitive, simpler, and more rapid than the log 50% cell culture infectious dose-ELISA (lgCCID50-ELISA) in measuring the rotavirus vaccines. IFA provided a reliable basis for the qualitative and quantitative analysis of rotavirus, and the certification of rotavirus vaccine production.

  13. Theoretical research on color indirect effects

    NASA Astrophysics Data System (ADS)

    Liu, T. C.; Liao, Changjun; Liu, Songhao

    1995-05-01

    Color indirect effects (CIE) means the physiological and psychological effects of color resulting from color vision. In this paper, we study CIE from the viewpoints of the integrated western and Chinese traditional medicine and the time quantum theory established by C. Y. Liu et al., respectively, and then put forward the color-automatic-nervous-subsystem model that could color excites parasympathetic subsystem and hot color excites sympathetic subsystem. Our theory is in agreement with modern color vision theory, and moreover, it leads to the resolution of the conflict between the color code theory and the time code theory oncolor vision. For the latitude phenomena on athlete stars number and the average lifespan, we also discuss the possibility of UV vision. The applications of our theory lead to our succeeding in explaining a number of physiological and psychological effects of color, in explaining the effects of age on color vision, and in explaining the Chinese chromophototherapy. We also discuss its application to neuroimmunology. This research provides the foundation of the clinical applications of chromophototherapy.

  14. Environmental risk analysis for indirect coal liquefaction

    SciTech Connect

    Barnthouse, L.W.; Suter, G.W. II; Baes, C.F. III; Bartell, S.M.; Cavendish, M.G.; Gardner, R.H.; O'Neill, R.V.; Rosen, A.E.

    1985-01-01

    This report presents an analysis of the risks to fish, water quality (due to noxious algal blooms), crops, forests, and wildlife of two technologies for the indirect liquefaction of coal: Lurgi and Koppers-Totzek gasification of coal for Fischer-Tropsch synthesis. A variety of analytical techniques were used to make maximum use of the available data to consider effects of effluents on different levels of ecological organization. The most significant toxicants to fish were found to be ammonia, cadmium, and acid gases. An analysis of whole-effluent toxicity indicated that the Lurgi effluent is more acutely toxic than the Koppers-Totzek effluent. Six effluent components appear to pose a potential threat of blue-green algal blooms, primarily because of their effects on higher trophic levels. The most important atmospheric emissions with respect to crops, forests, and wildlife were found to be the conventional combustion products SO/sub 2/ and NO/sub 2/. Of the materials deposited on the soil, arsenic, cadmium, and nickel appear of greatest concern for phytotoxicity. 147 references, 5 figures, 41 tables.

  15. Decentralized indirect methods for learning automata games.

    PubMed

    Tilak, Omkar; Martin, Ryan; Mukhopadhyay, Snehasis

    2011-10-01

    We discuss the application of indirect learning methods in zero-sum and identical payoff learning automata games. We propose a novel decentralized version of the well-known pursuit learning algorithm. Such a decentralized algorithm has significant computational advantages over its centralized counterpart. The theoretical study of such a decentralized algorithm requires the analysis to be carried out in a nonstationary environment. We use a novel bootstrapping argument to prove the convergence of the algorithm. To our knowledge, this is the first time that such analysis has been carried out for zero-sum and identical payoff games. Extensive simulation studies are reported, which demonstrate the proposed algorithm's fast and accurate convergence in a variety of game scenarios. We also introduce the framework of partial communication in the context of identical payoff games of learning automata. In such games, the automata may not communicate with each other or may communicate selectively. This comprehensive framework has the capability to model both centralized and decentralized games discussed in this paper.

  16. Spherical cows in dark matter indirect detection

    NASA Astrophysics Data System (ADS)

    Bernal, Nicolás; Necib, Lina; Slatyer, Tracy R.

    2016-12-01

    Dark matter (DM) halos have long been known to be triaxial, but in studies of possible annihilation and decay signals they are often treated as approximately spherical. In this work, we examine the asymmetry of potential indirect detection signals of DM annihilation and decay, exploiting the large statistics of the hydrodynamic simulation Illustris. We carefully investigate the effects of the baryons on the sphericity of annihilation and decay signals for both the case where the observer is at 8.5 kpc from the center of the halo (exemplified in the case of Milky Way-like halos), and for an observer situated well outside the halo. In the case of Galactic signals, we find that both annihilation and decay signals are expected to be quite symmetric, with axis ratios very different from 1 occurring rarely. In the case of extragalactic signals, while decay signals are still preferentially spherical, the axis ratio for annihilation signals has a much flatter distribution, with elongated profiles appearing frequently. Many of these elongated profiles are due to large subhalos and/or recent mergers. Comparing to gamma-ray emission from the Milky Way and X-ray maps of clusters, we find that the gamma-ray background appears less spherical/more elongated than the expected DM signal from the large majority of halos, and the Galactic gamma ray excess appears very spherical, while the X-ray data would be difficult to distinguish from a DM signal by elongation/sphericity measurements alone.

  17. 48 CFR 342.705 - Final indirect cost rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and local governments, colleges and universities, hospitals, and other nonprofit organizations. (b) The Division of Financial Advisory Services, NIH, shall establish indirect cost rates, fringe...

  18. Regulatory focus and work-related outcomes: a review and meta-analysis.

    PubMed

    Lanaj, Klodiana; Chang, Chu-Hsiang Daisy; Johnson, Russell E

    2012-09-01

    Regulatory focus theory (Higgins, 1997) has received growing attention in organizational psychology, necessitating a quantitative review that synthesizes its effects on important criteria. In addition, there is need for theoretical integration of regulatory focus theory with personality research. Theoretical integration is particularly relevant, since personality traits and dispositions are distal factors that are unlikely to have direct effects on work behaviors, yet they may have indirect effects via regulatory focus. The current meta-analysis introduces an integrative framework in which the effects of personality on work behaviors are best understood when considered in conjunction with more proximal motivational processes such as regulatory focus. Using a distal-proximal approach, we identify personality antecedents and work-related consequences of regulatory foci in a framework that considers both general and work-specific regulatory foci as proximal motivational processes. We present meta-analytic results for relations of regulatory focus with its antecedents (approach and avoid temperaments, conscientiousness, openness to experience, agreeableness, self-esteem, and self-efficacy) and its consequences (work behaviors and attitudes). In addition to estimates of bivariate relationships, we support a meta-analytic path model in which distal personality traits relate to work behaviors via the mediating effects of general and work-specific regulatory focus. Results from tests of incremental and relative validity indicated that regulatory foci predict unique variance in work behaviors after controlling for established personality, motivation, and attitudinal predictors. Consistent with regulatory focus theory and our integrative theoretical framework, regulatory focus has meaningful relations with work outcomes and is not redundant with other individual difference variables.

  19. Prostate Focused Ultrasound Therapy.

    PubMed

    Chapelon, Jean-Yves; Rouvière, Olivier; Crouzet, Sébastien; Gelet, Albert

    2016-01-01

    The tremendous progress in engineering and computing power coupled with ultrasound transducer technology and imaging modalities over the past 20 years have encouraged a revival of clinical interest in ultrasound therapy, mainly in High-Intensity Focused Ultrasound (HIFU). So far, the most extensive results from HIFU obtained in urology involve transrectal prostate ablation, which appears to be an effective therapeutic alternative for patients with malignant prostate tumors. Prostate cancer (PCa) is one of the most frequently diagnosed cancers in men. Several treatment options with different therapeutic approaches exist, including HIFU for localized PCa that has been in use for over 15 years. Since the early 2000s, two systems have been marketed for this application, and other devices are currently in clinical trials. HIFU treatment can be used either alone or in combination with (before- or after-) external beam radiotherapy (EBRT) (before or after HIFU) and can be repeated multiple times. HIFU treatment is performed under real-time monitoring with ultrasound or guided by MRI. Two indications are validated today: Primary care treatment and EBRT failure. The results of HIFU for primary care treatment are similar to standard conformal EBRT, even though no randomized comparative studies have been performed and no 10-year follow up data is yet available for HIFU. Salvage HIFU after EBRT failure is increasing with oncological outcomes, similar to those achieved with surgery but with the advantage of fewer adverse effects. HIFU is an evolving technology perfectly adapted for focal treatment. Thus, HIFU focal therapy is another pathway that must be explored when considering the accuracy and reliability for PCa mapping techniques. HIFU would be particularly suited for such a therapy since it is clear that HIFU outcomes and toxicity are relative to the volume of prostate treated.

  20. A novel automated indirect immunofluorescence autoantibody evaluation.

    PubMed

    Kivity, Shaye; Gilburd, Boris; Agmon-Levin, Nancy; Carrasco, Marina Garcia; Tzafrir, Yaron; Sofer, Yael; Mandel, Matilda; Buttner, Thomas; Roggenbuck, Dirk; Matucci-Cerinic, Marco; Danko, Katalin; Hoyos, Marcos López; Shoenfeld, Yehuda

    2012-03-01

    Autoantibodies (AAb), especially antinuclear (ANAs) and anticytoplasmatic antibodies (ACyA), are essential diagnosing markers for several autoimmune diseases. The current gold standard method for ANA detection is manual indirect immunofluorescence (IIF) on human epithelial-2 (HEp-2) cells. However, this technique is cost and time consuming, and characterized by considerable intra- and interlaboratory variability. Thus, an automated IIF-HEp-2 reader has been developed recently. In the current study, we compared the performance of the automated AAb IIF-HEp-2 interpretation to conventional detection methods. Autoantibody detection by IIF on HEp-2 cells was performed in a total of 260 sera of patients, including 34 with systemic lupus erythematosus, 111 with dermatomyositis or polymyositis, 74 with systemic sclerosis, 41 with rare AAb patterns, and 137 healthy individuals. Visual interpretation and routine immunoassays were compared with a novel automated IIF-HEp-2 system using Aklides pattern recognition algorithms. Positive AAbs were detected in 95-100% of rheumatic patients by automated interpretation, in 74-100% with manual reading, and in 64-100% by immunodot assay. Receiver operating characteristic curve analysis of fluorescent intensity revealed a high sensitivity and specificity for automated reading of AAb with an agreement ranging from 90% to 95% between manual and automated interpretation (kappa 0.554-0.69) for systemic sclerosis and myositis, respectively. This study demonstrates a good correlation between manual and automated interpretation of AAb including ANA and ACyA in patients with autoimmune diseases. Full automation of HEp-2 cell assay reading may minimize errors in ANA pattern interpretation and thus help in the standardization of ANA assessment.

  1. Gene network coherence based on prior knowledge using direct and indirect relationships.

    PubMed

    Gómez-Vela, Francisco; Lagares, José Antonio; Díaz-Díaz, Norberto

    2015-06-01

    Gene networks (GNs) have become one of the most important approaches for modeling biological processes. They are very useful to understand the different complex biological processes that may occur in living organisms. Currently, one of the biggest challenge in any study related with GN is to assure the quality of these GNs. In this sense, recent works use artificial data sets or a direct comparison with prior biological knowledge. However, these approaches are not entirely accurate as they only take into account direct gene-gene interactions for validation, leaving aside the weak (indirect) relationships. We propose a new measure, named gene network coherence (GNC), to rate the coherence of an input network according to different biological databases. In this sense, the measure considers not only the direct gene-gene relationships but also the indirect ones to perform a complete and fairer evaluation of the input network. Hence, our approach is able to use the whole information stored in the networks. A GNC JAVA-based implementation is available at: http://fgomezvela.github.io/GNC/. The results achieved in this work show that GNC outperforms the classical approaches for assessing GNs by means of three different experiments using different biological databases and input networks. According to the results, we can conclude that the proposed measure, which considers the inherent information stored in the direct and indirect gene-gene relationships, offers a new robust solution to the problem of GNs biological validation.

  2. Indirect ophthalmoscopic stereo video system using three-dimensional LCD

    NASA Astrophysics Data System (ADS)

    Kong, Hyoun-Joong; Seo, Jong Mo; Hwang, Jeong Min; Kim, Hee Chan

    2009-02-01

    Binocular indirect ophthalmoscope (BIO) provides a wider view of fundus with stereopsis contrary to the direct one. Proposed system is composed of portable BIO and 3D viewing unit. The illumination unit of BIO utilized high flux LED as a light source, LED condensing lens cap for beam focusing, color filters and small lithium ion battery. In optics unit of BIO, beam splitter was used to distribute an examinee's fundus image both to examiner's eye and to CMOS camera module attached to device. Captured retinal video stream data from stereo camera modules were sent to PC through USB 2.0 connectivity. For 3D viewing, two video streams having parallax between them were aligned vertically and horizontally and made into side-by-side video stream for cross-eyed stereoscopy. And the data were converted into autostereoscopic video stream using vertical interlacing for stereoscopic LCD which has glass 3D filter attached to the front side of it. Our newly devised system presented the real-time 3-D view of fundus to assistants with less dizziness than cross-eyed stereoscopy. And the BIO showed good performance compared to conventional portable BIO (Spectra Plus, Keeler Limited, Windsor, UK).

  3. Nonlinear indirect combustion noise for compact supercritical nozzle flows

    NASA Astrophysics Data System (ADS)

    Huet, M.

    2016-07-01

    In this paper, indirect combustion noise generated by the acceleration of entropy perturbations through a supercritical nozzle is investigated in the nonlinear regime and in the low-frequency limit (quasi-static hypothesis). This work completes the study of Huet and Giauque (Journal of Fluid Mechanics 733 (2013) 268-301) for nonlinear noise generation in nozzle flows without shock and particularly focuses on shocked flow regimes. It is based on the analytical model of Marble and Candel for compact nozzles (Journal of Sound and Vibration 55 (1977) 225-243), initially developed for excitations in the linear regime and rederived here for nonlinear perturbations. Full nonlinear analytical solutions are provided in the absence of shock as well as second-order analytical expressions when a shock is present in the diffuser. An analytical evaluation of the shock displacement inside the nozzle caused by the forcing is proposed and maximum possible forcings to avoid unchoke and 'over-choke' are discussed. The accuracy of the second-order model and the nonlinear contributions to the generated waves are then addressed. This model is found to be very accurate for the generated entropy wave with negligible nonlinear contributions. Nonlinearities are more visible, but still limited, for the downstream acoustic wave for large inlet Mach numbers. Analytical developments are validated thanks to comparisons with numerical simulations.

  4. Habitat restoration affects immature stages of a wetland butterfly through indirect effects on predation.

    PubMed

    Aschehoug, Erik T; Sivakoff, F S; Cayton, H L; Morris, W F; Haddad, N M

    2015-07-01

    Habitat loss worldwide has led to the widespread use of restoration practices for the recovery of imperiled species. However, recovery success may be hampered by focusing on plant communities, rather than the complex suite of direct and indirect interactions among trophic levels that occur in natural systems. Through a factorial field experiment, we tested the effects of wetland restoration on egg and juvenile survival of a locally rare butterfly, Satyrodes appalachia, via tree removal and damming. Tree removal more than tripled S. appalachia host plant abundance, but neither restoration action directly affected S. appalachia egg and juvenile survival. Instead, we found strong indirect effects of habitat manipulation on S. appalachia egg and juvenile survival that were mediated through predation. The interaction of tree removal and damming significantly decreased predation of S. appalachia eggs relative to each treatment alone. Damming alone had a significant positive indirect effect on the survival of S. appalachia juveniles, likely because increases in standing water reduced predator access. Our results emphasize the need for experiments that evaluate the demographic responses of imperiled species to habitat restoration prior to management action and quantify potential indirect effects mediated through higher trophic levels.

  5. Effects of Direct and Indirect Instruction on Fostering Decision-Making Competence in Socioscientific Issues

    NASA Astrophysics Data System (ADS)

    Böttcher, Florian; Meisert, Anke

    2013-04-01

    In this study the effects of different learning environments on the promotion of decision-making competence for the socioscientific issue of genetically modified crops is investigated. The comparison focuses on direct vs. indirect instructions. Therefore on the one hand a sophisticated decision-making strategy was presented to the directly instructed experimental group (1) and had to be applied correctly. On the other hand indirectly instructed students had to invent an appropriate strategy by themselves (2) based on the given information and the structure of the problem context. Group discussions are analysed qualitatively in order (1) to outline how the given strategy was understood and its results were reflected on by the students and (2) to explore the characteristics of invented strategies and their degree of complexity. Results indicate that the direct instruction of complex decision-making strategies may lead to a lack of understanding of the decision process when the given strategy is applied and therefore may cause rejection of the final decision. Indirectly instructed students were able to invent sophisticated decision-making strategies containing compensatory trade-offs. It is concluded that when directly instructing complex decision-making strategies, essential parts of reflection have to be integrated in order to gain greater transparency. Accordingly, empirical evidence has been found to consider indirect instruction as a possible way to foster decision-making strategies for complex socioscientific issues even if compensatory procedures are considered to be necessary.

  6. Automobile Industry Retail Price Equivalent and Indirect Cost Multipliers

    EPA Science Inventory

    This report develops a modified multiplier, referred to as an indirect cost (IC) multiplier, which specifically evaluates the components of indirect costs that are likely to be affected by vehicle modifications associated with environmental regulation. A range of IC multipliers a...

  7. Direct and Indirect Cues to Knowledge States during Word Learning

    ERIC Educational Resources Information Center

    Saylor, Megan M.; Carroll, C. Brooke

    2009-01-01

    The present study investigated three-year-olds' sensitivity to direct and indirect cues to others' knowledge states for word learning purposes. Children were given either direct, physical cues to knowledge or indirect, verbal cues to knowledge. Preschoolers revealed a better ability to learn words from a speaker following direct, physical cues to…

  8. A Comparison of Direct and Indirect Writing Assessment Methods.

    ERIC Educational Resources Information Center

    Stiggins, Richard J.

    An area of current concern is that of the advantages and disadvantages of measuring writing proficiency directly via writing samples, and indirectly via objective tests. Much research has been completed documenting the correlation between direct and indirect measures. However, there had not yet been a systematic and detailed conceptual analysis…

  9. 10 CFR 602.15 - Indirect cost limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Indirect cost limitations. 602.15 Section 602.15 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS EPIDEMIOLOGY AND OTHER HEALTH STUDIES FINANCIAL ASSISTANCE PROGRAM § 602.15 Indirect cost limitations. Awards issued under this part for conferences...

  10. Comprehension of Indirect Meaning in Spanish as a Foreign Language

    ERIC Educational Resources Information Center

    Taguchi, Naoko; Gomez-Laich, Maria Pia; Arrufat-Marques, Maria-Jose

    2016-01-01

    This study investigated comprehension of indirect meaning among learners of L2 Spanish via an original computer-delivered multimedia listening test. The comprehension of implied speaker intention is a type of indirect communication that involves the ability to understand implied intention by using linguistic knowledge, contextual cues, and the…

  11. 48 CFR 1542.703-2 - Certificate of indirect costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Certificate of indirect costs. 1542.703-2 Section 1542.703-2 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Indirect Cost Rates 1542.703-2 Certificate of...

  12. Alleged Approach-Avoidance Conflict for Food Stimuli in Binge Eating Disorder

    PubMed Central

    Leehr, Elisabeth J.; Schag, Kathrin; Brinkmann, Amelie; Ehlis, Ann-Christine; Fallgatter, Andreas J.; Zipfel, Stephan; Giel, Katrin E.; Dresler, Thomas

    2016-01-01

    Objective Food stimuli are omnipresent and naturally primary reinforcing stimuli. One explanation for the intake of high amounts of food in binge eating disorder (BED) is a deviant valuation process. Valuation of food stimuli is supposed to influence approach or avoidance behaviour towards food. Focusing on self-reported and indirect (facial electromyography) valuation process, motivational aspects in the processing of food stimuli were investigated. Methods We compared an overweight sample with BED (BED+) with an overweight sample without BED (BED-) and with normal weight controls (NWC) regarding their self-reported and indirect (via facial electromyography) valuation of food versus non-food stimuli. Results Regarding the self-reported valuation, the BED+ sample showed a significantly stronger food-bias compared to the BED- sample, as food stimuli were rated as significantly more positive than the non-food stimuli in the BED+ sample. This self-reported valuation pattern could not be displayed in the indirect valuation. Food stimuli evoked negative indirect valuation in all groups. The BED+ sample showed the plainest approach-avoidance conflict marked by a diverging self-reported (positive) and indirect (negative) valuation of food stimuli. Conclusions BED+ showed a deviant self-reported valuation of food as compared to BED-. The valuation process of the BED+ sample seems to be characterized by a motivational ambivalence. This ambivalence should be subject of further studies and may be of potential use for therapeutic interventions. PMID:27045169

  13. Modified habitats influence kelp epibiota via direct and indirect effects.

    PubMed

    Marzinelli, Ezequiel M; Underwood, Antony J; Coleman, Ross A

    2011-01-01

    Addition of man-made structures alters abiotic and biotic characteristics of natural habitats, which can influence abundances of biota directly and/or indirectly, by altering the ecology of competitors or predators. Marine epibiota in modified habitats were used to test hypotheses to distinguish between direct and indirect processes. In Sydney Harbour, kelps on pier-pilings supported greater covers of bryozoans, particularly of the non-indigenous species Membranipora membranacea, than found on natural reefs. Pilings influenced these patterns and processes directly due to the provision of shade and indirectly by altering abundances of sea-urchins which, in turn, affected covers of bryozoans. Indirect effects were more important than direct effects. This indicates that artificial structures affect organisms living on secondary substrata in complex ways, altering the biodiversity and indirectly affecting abundances of epibiota. Understanding how these components of habitats affect ecological processes is necessary to allow sensible prediction of the effects of modifying habitats on the ecology of organisms.

  14. Forecasting of indirect consumables for a Job Shop

    NASA Astrophysics Data System (ADS)

    Shakeel, M.; Khan, S.; Khan, W. A.

    2016-08-01

    A job shop has an arrangement where similar machines (Direct consumables) are grouped together and use indirect consumables to produce a product. The indirect consumables include hack saw blades, emery paper, painting brush etc. The job shop is serving various orders at a particular time for the optimal operation of job shop. Forecasting is required to predict the demand of direct and indirect consumables in a job shop. Forecasting is also needed to manage lead time, optimize inventory cost and stock outs. The objective of this research is to obtain the forecast for indirect consumables. The paper shows how job shop can manage their indirect consumables more accurately by establishing a new technique of forecasting. This results in profitable use of job shop by multiple users.

  15. Microfabricated particle focusing device

    DOEpatents

    Ravula, Surendra K.; Arrington, Christian L.; Sigman, Jennifer K.; Branch, Darren W.; Brener, Igal; Clem, Paul G.; James, Conrad D.; Hill, Martyn; Boltryk, Rosemary June

    2013-04-23

    A microfabricated particle focusing device comprises an acoustic portion to preconcentrate particles over large spatial dimensions into particle streams and a dielectrophoretic portion for finer particle focusing into single-file columns. The device can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

  16. FOCUS: Sustainable Mathematics Successes

    ERIC Educational Resources Information Center

    Mireles, Selina V.; Acee, Taylor W.; Gerber, Lindsey N.

    2014-01-01

    The FOCUS (Fundamentals of Conceptual Understanding and Success) Co-Requisite Model Intervention (FOCUS Intervention) for College Algebra was developed as part of the Developmental Education Demonstration Projects (DEDP) in Texas. The program was designed to use multiple services, courses, and best practices to support student completion of a…

  17. Focus, 2000-2001.

    ERIC Educational Resources Information Center

    Focus, 2001

    2001-01-01

    These three issues of 2000-2001 "Focus" present a collection of papers focusing on issues related to poverty. The first issue discusses child support enforcement policy and low-income families, highlighting such issues as fragile families and child wellbeing; low-income families and the child support enforcement system; child support…

  18. The Indirect Effect of Alcohol Use on GPA in First-Semester College Students: The Mediating Role of Academic Effort

    ERIC Educational Resources Information Center

    Conway, James M.; DiPlacido, Joanne

    2015-01-01

    This study focused on first-semester college students, investigating (a) indirect effects of aggregate alcohol use on grade point average (GPA) through academic effort (skipping class and time on schoolwork) and (b) daily effects of alcohol use on reduced effort. Eighty students reported daily alcohol use and academic effort (skipping class and…

  19. UAVEMI Project: Numerical and Experimental EM Immunity Assessment of UAV for HIRF and Lightning Indirect Effects

    NASA Astrophysics Data System (ADS)

    Garcia, Salvador G.; Silvia, Ferran; Escot, David; Pascual, Enrique; Pantoja, Mario F.; Riu, Pere; Anon, Manuel; Alvarez, Jesus; Cabello, M.; Pous, Marc; Fernandez, Sergio; Trallero, Rafael; Poyatos, David; Nuno, Luis

    2016-05-01

    The UAVEMI project, funded by the Spanish Ministry of Economy and Competitiveness, gathers a consortium formed by several research and development institutions and one industrial partner. The main goal is to develop innovative experimental and numerical approaches for the assessment of the electromagnetic compatibility of unmanned air vehicles, under high intensity radiated fields, lightning indirect effects and non-nuclear electromagnetic pulses. This contribution describes the capabilities currently being developed under the project.

  20. Fluorescence quenching as an indirect detection method for nitrated explosives.

    PubMed

    Goodpaster, J V; McGuffin, V L

    2001-05-01

    A novel approach based on fluorescence quenching is presented for the analysis of nitrated explosives. Seventeen common explosives and their degradation products are shown to be potent quenchers of pyrene, having Stern-Volmer constants that generally increase with the degree of nitration. Aromatic explosives such as 2,4,6-trinitrotoluene (2,4,6-TNT) are more effective quenchers than aliphatic or nitramine explosives. In addition, nitroaromatic explosives are found to have unique interactions with pyrene that lead to a wavelength dependence of their Stern-Volmer constants. This phenomenon allows for their differentiation from other nitrated explosives. The fluorescence quenching method is then applied to the determination of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazine(HMX), 2,4,6-TNT, nitromethane, and ammonium nitrate in various commercial explosive samples. The samples are separated by capillary liquid chromatography with post-column addition of the pyrene solution and detection by laser-induced fluorescence. The indirect fluorescence quenching method shows increased sensitivity and selectivity over traditional UV-visible absorbance as well as the ability to detect a wider range of organic and inorganic nitrated compounds.

  1. Improved Fischer-Tropsch catalysts for indirect coal liquefaction

    SciTech Connect

    Wilson, R.B. Jr.; Tong, G.T.; Chan, Y.W.; Huang, H.W.; McCarty, J.G.

    1989-02-01

    The Fischer-Tropsch synthesis (FTS)reaction is the established technology for the production of liquid fuels from coal by an indirect route using coal-derived syngas (CO + H{sub 2}). Modern FTS catalysts are potassium- and copper-promoted iron preparations. These catalysts exhibit moderate activity with carbon monoxide-rich feedstocks such as the syngas produced by advanced coal gasification processes. However, the relatively large yields of by-product methane and high-molecular-weight hydrocarbon waxes detract from the production of desired liquid products in the C{sub 5}-C{sub 16} range needed for motor and aviation fuel. The goal of this program is to decrease undesirable portions of the FTS hydrocarbon yield by altering the Schultz-Flory polymerization product distribution through design and formulation of improved catalysts. Two approaches were taken: (1) reducing the yield of high-molecular-weight hydrocarbon waxes by using highly dispersed catalysts produced from surface-confined multiatomic clusters on acid supports and (2) suppressing methane production by uniformly pretreating active, selective conventional FTS catalysts with submonolayer levels of sulfur.

  2. Indirect pulp therapy: an alternative to pulpotomy in primary teeth.

    PubMed

    Seale, N Sue

    2010-11-01

    Preservation of the primary teeth until their normal exfoliation is essential for normal oral function and facial growth of the child. To that end, treatment of primary teeth with large carious lesions approximating the pulp should be aimed at preserving the tooth. Currently, the pulpotomy is the most frequently used pulp treatment for cariously involved primary teeth. The purpose of this manuscript is to describe the use of an alternative to the pulpotomy, indirect pulp therapy (IPT), for the treatment of vital, primary teeth with carious involvement approaching the pulp. Accurate diagnosis of the vitality status of the pulp is critical to the success of IPT and involves careful radiographic and clinical assessment of the teeth to be sure they are healthy or at worst, reversibly inflamed. The indications for IPT are the same as for pulpotomy. The technique involves one appointment, requires that some carious dentin be left to avoid pulp exposure and requires the placement of a biologically sealing base and sealing final restoration. Teeth treated with IPT have success rates at least as good as those treated with pulpotomies, and IPT offers an acceptable alternative to pulpotomy as a treatment for vital, asymptomatic, cariously involved primary teeth.

  3. Performance evaluation of indirect evaporative cooler using clay pot

    NASA Astrophysics Data System (ADS)

    Ramkumar, R.; Ragupathy, A.

    2016-05-01

    The aim of the experimental study is to investigate the performance of indirect evaporator cooler in hot and humid regions. A novel approach is implemented in the cooler using clay pot with different position (single, double and three pots) and different orientation as aligned and staggered position for potential and feasibility study. The clay pot is the ceramic material where the water filled inside the pot and due to the property of porosity, the water comes outer surface of the pot and contact with the air passing over the pot surface and air get cooled. A test rig was designed and fabricated to collect experimental data. The clay pots were arranged in aligned and staggered position. In our study heat transfer was analysed with various air velocity of 1m/s to 5m/s. The air temperature, relative humidity, pressure drop and effectiveness were measured and the performance of the evaporative cooler was evaluated. The analysis of the data indicated that cooling effectiveness improve with decrease of air velocity at staggered position. It was shown that staggered position has the higher performance (57%) at 1 m/s air velocity comparison with aligned position values at three pots position.

  4. Algorithms for Labeling Focus Regions.

    PubMed

    Fink, M; Haunert, Jan-Henrik; Schulz, A; Spoerhase, J; Wolff, A

    2012-12-01

    In this paper, we investigate the problem of labeling point sites in focus regions of maps or diagrams. This problem occurs, for example, when the user of a mapping service wants to see the names of restaurants or other POIs in a crowded downtown area but keep the overview over a larger area. Our approach is to place the labels at the boundary of the focus region and connect each site with its label by a linear connection, which is called a leader. In this way, we move labels from the focus region to the less valuable context region surrounding it. In order to make the leader layout well readable, we present algorithms that rule out crossings between leaders and optimize other characteristics such as total leader length and distance between labels. This yields a new variant of the boundary labeling problem, which has been studied in the literature. Other than in traditional boundary labeling, where leaders are usually schematized polylines, we focus on leaders that are either straight-line segments or Bezier curves. Further, we present algorithms that, given the sites, find a position of the focus region that optimizes the above characteristics. We also consider a variant of the problem where we have more sites than space for labels. In this situation, we assume that the sites are prioritized by the user. Alternatively, we take a new facility-location perspective which yields a clustering of the sites. We label one representative of each cluster. If the user wishes, we apply our approach to the sites within a cluster, giving details on demand.

  5. Comparison of Direct and Indirect Measures of E-cigarette Risk Perceptions

    PubMed Central

    Wackowski, Olivia A.; Bover Manderski, Michelle T.; Delnevo, Cristine D.

    2015-01-01

    Objectives Risk perception measures of tobacco products relative to cigarettes are commonly used and important to tobacco research given that they may be associated with and predict tobacco use. However, results may differ based on measures used. This study compares direct and indirect approaches to measuring e-cigarette/cigarette risk perceptions. Methods We compared the responses of 519 current smokers on a nationally representative 2014 survey that gauged perceptions of e-cigarettes’ harm relative to cigarettes in two ways: 1) a single-item direct measure of comparative harm and a two-item indirect measure (which measured perceived levels of harm from e-cigarettes and cigarettes independently in two parallel questions). Results We found that 60% of smokers rated e-cigarettes “less harmful” than cigarettes when using a direct comparative risk measure versus 73% when using an indirect measure. Agreement between measure types was fair (Cohen’s Kappa=0.45) and was lower for males, Blacks, older and less educated smokers. Conclusions E-cigarettes were more likely to be rated by smokers as less harmful than cigarettes when using indirect versus direct measures. Additional methodology research into this area is warranted given the importance of risk perceptions to tobacco control interventions, communications, policy-making and regulation. PMID:26855966

  6. The price of being seen to be just: an intention signalling strategy for indirect reciprocity.

    PubMed

    Tanaka, Hiroki; Ohtsuki, Hisashi; Ohtsubo, Yohsuke

    2016-07-27

    Cooperation among strangers is a marked characteristic of human sociality. One prominent evolutionary explanation for this form of human cooperation is indirect reciprocity, whereby each individual selectively helps people with a 'good' reputation, but not those with a 'bad' reputation. Some evolutionary analyses have underscored the importance of second-order reputation information (the reputation of a current partner's previous partner) for indirect reciprocity as it allows players to discriminate justified 'good' defectors, who selectively deny giving help to 'bad' partners, from unjustified 'bad' defectors. Nevertheless, it is not clear whether people in fact make use of second-order information in indirect reciprocity settings. As an alternative, we propose the intention signalling strategy, whereby defectors are given the option to abandon a resource as a means of expunging their 'bad' reputation. Our model deviates from traditional modelling approaches in the indirect reciprocity literature in a crucial way-we show that first-order information is sufficient to maintain cooperation if players are given an option to signal their intention. Importantly, our model is robust against invasion by both unconditionally cooperative and uncooperative strategies, a first step towards demonstrating its viability as an evolutionarily stable strategy. Furthermore, in two behavioural experiments, when participants were given the option to abandon a resource so as to mend a tarnished reputation, participants not only spontaneously began to use this option, they also interpreted others' use of this option as a signal of cooperative intent.

  7. Focused ultrasound in ophthalmology

    PubMed Central

    Silverman, Ronald H

    2016-01-01

    The use of focused ultrasound to obtain diagnostically significant information about the eye goes back to the 1950s. This review describes the historical and technological development of ophthalmic ultrasound and its clinical application and impact. Ultrasound, like light, can be focused, which is crucial for formation of high-resolution, diagnostically useful images. Focused, single-element, mechanically scanned transducers are most common in ophthalmology. Specially designed transducers have been used to generate focused, high-intensity ultrasound that through thermal effects has been used to treat glaucoma (via ciliodestruction), tumors, and other pathologies. Linear and annular transducer arrays offer synthetic focusing in which precise timing of the excitation of independently addressable array elements allows formation of a converging wavefront to create a focus at one or more programmable depths. Most recently, linear array-based plane-wave ultrasound, in which the array emits an unfocused wavefront and focusing is performed solely on received data, has been demonstrated for imaging ocular anatomy and blood flow. While the history of ophthalmic ultrasound extends back over half-a-century, new and powerful technologic advances continue to be made, offering the prospect of novel diagnostic capabilities. PMID:27757007

  8. Focused ultrasound in ophthalmology.

    PubMed

    Silverman, Ronald H

    2016-01-01

    The use of focused ultrasound to obtain diagnostically significant information about the eye goes back to the 1950s. This review describes the historical and technological development of ophthalmic ultrasound and its clinical application and impact. Ultrasound, like light, can be focused, which is crucial for formation of high-resolution, diagnostically useful images. Focused, single-element, mechanically scanned transducers are most common in ophthalmology. Specially designed transducers have been used to generate focused, high-intensity ultrasound that through thermal effects has been used to treat glaucoma (via ciliodestruction), tumors, and other pathologies. Linear and annular transducer arrays offer synthetic focusing in which precise timing of the excitation of independently addressable array elements allows formation of a converging wavefront to create a focus at one or more programmable depths. Most recently, linear array-based plane-wave ultrasound, in which the array emits an unfocused wavefront and focusing is performed solely on received data, has been demonstrated for imaging ocular anatomy and blood flow. While the history of ophthalmic ultrasound extends back over half-a-century, new and powerful technologic advances continue to be made, offering the prospect of novel diagnostic capabilities.

  9. Flat Focusing Mirror

    PubMed Central

    Cheng, Y. C.; Kicas, S.; Trull, J.; Peckus, M.; Cojocaru, C.; Vilaseca, R.; Drazdys, R.; Staliunas, K.

    2014-01-01

    The control of spatial propagation properties of narrow light beams such as divergence, focusing or imaging are main objectives in optics and photonics. In this letter, we propose and demonstrate experimentally a flat focusing mirror, based on an especially designed dielectric structure without any optical axis. More generally, it also enables imaging any light pattern in reflection. The flat focusing mirror with a transversal invariance can largely increase the applicability of structured photonic materials for light beam propagation control in small-dimension photonic circuits. PMID:25228358

  10. On the characteristics of aerosol indirect effect based on dynamic regimes in global climate models

    DOE PAGES

    Zhang, Shipeng; Wang, Minghuai; Ghan, Steven J.; ...

    2016-03-04

    Aerosol–cloud interactions continue to constitute a major source of uncertainty for the estimate of climate radiative forcing. The variation of aerosol indirect effects (AIE) in climate models is investigated across different dynamical regimes, determined by monthly mean 500 hPa vertical pressure velocity (ω500), lower-tropospheric stability (LTS) and large-scale surface precipitation rate derived from several global climate models (GCMs), with a focus on liquid water path (LWP) response to cloud condensation nuclei (CCN) concentrations. The LWP sensitivity to aerosol perturbation within dynamic regimes is found to exhibit a large spread among these GCMs. It is in regimes of strong large-scale ascentmore » (ω500  <  −25 hPa day−1) and low clouds (stratocumulus and trade wind cumulus) where the models differ most. Shortwave aerosol indirect forcing is also found to differ significantly among different regimes. Shortwave aerosol indirect forcing in ascending regimes is close to that in subsidence regimes, which indicates that regimes with strong large-scale ascent are as important as stratocumulus regimes in studying AIE. It is further shown that shortwave aerosol indirect forcing over regions with high monthly large-scale surface precipitation rate (> 0.1 mm day−1) contributes the most to the total aerosol indirect forcing (from 64 to nearly 100 %). Results show that the uncertainty in AIE is even larger within specific dynamical regimes compared to the uncertainty in its global mean values, pointing to the need to reduce the uncertainty in AIE in different dynamical regimes.« less

  11. Food assistance programmes are indirectly associated with anaemia status in children <5 years old in Mexico.

    PubMed

    Shamah-Levy, Teresa; Méndez-Gómez-Humarán, Ignacio; Gaona-Pineda, Elsa B; Cuevas-Nasu, Lucia; Villalpando, Salvador

    2016-09-01

    Anaemia in children is a public health concern in Mexico; Federal food assistance programmes are being implemented to prevent it. We undertook this research to investigate the indirect association between food assistance programmes (FAP) and anaemia through dietary and socio-economic conditions of beneficiary children. A structural equation model (SEM) was constructed to assess associations among FAP, dietary and socio-economic conditions, as well as anaemia. A cross-sectional comparative study was conducted based on a sample of 1214 households with children <5 years old, beneficiaries of two FAP: Prospera and rescue from malnutrition with amaranth (RMA) and a comparison group in San Luis Potosí, Mexico. The SEM and a decomposition effect analysis revealed the existence of a significant indirect association of FAP on the prevalence of anaemia via dietary and socio-economic conditions in children under 5 years old. The Prospera assistance programme showed a significant indirect positive association with the prevalence of anaemia (standard coefficient=0·027, P<0·031), and the RMA programme showed a significant indirect negative association with the prevalence of anaemia (standard coefficient=-0·029, P=0·047). There was a direct association between FAP and dietary and socio-economic conditions. FAP could indirectly modify the prevalence of anaemia in young children with a direct improvement on dietary and socio-economic conditions. The unexpected finding of the association between RMA, dietary and socio-economic conditions and the prevalence of anaemia reflects differences in the focus of the programmes.

  12. How can we cope with the complexity of the environment? A "Learning by modelling" approach using qualitative reasoning for developing causal models and simulations with focus on Sustainable River Catchment Management

    NASA Astrophysics Data System (ADS)

    Poppe, Michaela; Zitek, Andreas; Salles, Paulo; Bredeweg, Bert; Muhar, Susanne

    2010-05-01

    land use in the catchments have created ecological problems. A sustainable, catchment-wide management of riverine landscapes is needed and stated by water right acts, e.g. the European Water Framework and Floods Directive. This interdisciplinary approach needs the integration of natural riverine processes, flood protection, resource management, landscape planning, and social and political aspects to achieve a sustainable development. Therefore the model shows the effects of different management strategies concerning flood protection, restoration measures and land use. The model illustrates the wide range of ecosystem services of riverine landscapes that contribute to human well-being such as water supply, hydropower generation, flood regulation, and recreational opportunities. The effects of different land use strategies in the catchment are highlighted by means of the Driver-Pressure-State-Impact-Response (DPSIR) framework. The model is used to support activities of students at the University as well as at High School within the DynaLearn Software to promote scientific culture in the secondary education system. Model fragments allow learners to re-use parts of the existing model at different levels of complexity. But learners can also construct their own conceptual system knowledge, either individually or in a collaborative setting, and using the model as a reference for comparisons of their own understanding. Of special interest for the DynaLearn project is the intended development of interdisciplinary and social skills like cooperative working, cross-linked thinking, problem solving, decision-making, and the identification of the conflicts between environment, economy, legislation, science, technology, and society. A comprehensive evaluation of the DynaLearn software is part of the project. To be effective, science education should focus on understanding scientific concepts and on application of scientific knowledge to everyday life. Conceptual knowledge of systems

  13. Facility Focus: Food Service.

    ERIC Educational Resources Information Center

    College Planning & Management, 2002

    2002-01-01

    Describes the Hawthorn Court Community Center at Iowa State University, Ames, and the HUB-Robeson Center at Pennsylvania State University. Focuses on the food service offered in these new student-life buildings. Includes photographs. (EV)

  14. Focusing corner cube

    DOEpatents

    Monjes, J.A.

    1985-09-12

    This invention retortreflects and focuses a beam of light. The invention comprises a modified corner cube reflector wherein one reflective surface is planar, a second reflective surface is spherical, and the third reflective surface may be planar or convex cylindrical.

  15. Inertial Focusing in Microfluidics

    PubMed Central

    Martel, Joseph M.; Toner, Mehmet

    2015-01-01

    When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent decades learning why such behavior occurred, finally understanding that it was caused by previously unknown forces on particles in an inertial flow. The advent of microfluidics opened a new realm of possibilities for inertial focusing in the processing of biological fluids and cellular suspensions and created a field that is now rapidly expanding. Over the past five years, inertial focusing has enabled high-throughput, simple, and precise manipulation of bodily fluids for a myriad of applications in point-of-care and clinical diagnostics. This review describes the theoretical developments that have made the field of inertial focusing what it is today and presents the key applications that will make inertial focusing a mainstream technology in the future. PMID:24905880

  16. Inertial focusing in microfluidics.

    PubMed

    Martel, Joseph M; Toner, Mehmet

    2014-07-11

    When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent decades learning why such behavior occurred, finally understanding that it was caused by previously unknown forces on particles in an inertial flow. The advent of microfluidics opened a new realm of possibilities for inertial focusing in the processing of biological fluids and cellular suspensions and created a field that is now rapidly expanding. Over the past five years, inertial focusing has enabled high-throughput, simple, and precise manipulation of bodily fluids for a myriad of applications in point-of-care and clinical diagnostics. This review describes the theoretical developments that have made the field of inertial focusing what it is today and presents the key applications that will make inertial focusing a mainstream technology in the future.

  17. Final focus nomenclature

    SciTech Connect

    Erickson, R.

    1986-08-08

    The formal names and common names for all devices in the final focus system of the SLC are listed. The formal names consist of a device type designator, microprocessor designator, and a four-digit unit number. (LEW)

  18. Final focus test beam

    SciTech Connect

    Not Available

    1991-03-01

    This report discusses the following: the Final Focus Test Beam Project; optical design; magnets; instrumentation; magnetic measurement and BPM calibration; mechanical alignment and stabilization; vacuum system; power supplies; control system; radiation shielding and personnel protection; infrastructure; and administration.

  19. Lateralized direct and indirect semantic priming effects in subjects with paranormal experiences and beliefs.

    PubMed

    Pizzagalli, D; Lehmann, D; Brugger, P

    2001-01-01

    The present investigation tested the hypothesis that, as an aspect of schizotypal thinking, the formation of paranormal beliefs was related to spreading activation characteristics within semantic networks. From a larger student population (n = 117) prescreened for paranormal belief, 12 strong believers and 12 strong disbelievers (all women) were invited for a lateralized semantic priming task with directly and indirectly related prime-target pairs. Believers showed stronger indirect (but not direct) semantic priming effects than disbelievers after left (but not right) visual field stimulation, indicating faster appreciation of distant semantic relations specifically by the right hemisphere, reportedly specialized in coarse rather than focused semantic processing. These results are discussed in the light of recent findings in schizophrenic patients with thought disorders. They suggest that a disinhibition with semantic networks may underlie the formation of paranormal belief. The potential usefulness of work with healthy subjects for neuropsychiatric research is stressed.

  20. Comparison of haemoglobin estimates using direct & indirect cyanmethaemoglobin methods

    PubMed Central

    Bansal, Priyanka Gupta; Toteja, Gurudayal Singh; Bhatia, Neena; Gupta, Sanjeev; Kaur, Manpreet; Adhikari, Tulsi; Garg, Ashok Kumar

    2016-01-01

    Background & objectives: Estimation of haemoglobin is the most widely used method to assess anaemia. Although direct cyanmethaemoglobin method is the recommended method for estimation of haemoglobin, but it may not be feasible under field conditions. Hence, the present study was undertaken to compare indirect cyanmethaemoglobin method against the conventional direct method for haemoglobin estimation. Methods: Haemoglobin levels were estimated for 888 adolescent girls aged 11-18 yr residing in an urban slum in Delhi by both direct and indirect cyanmethaemoglobin methods, and the results were compared. Results: The mean haemoglobin levels for 888 whole blood samples estimated by direct and indirect cyanmethaemoglobin method were 116.1 ± 12.7 and 110.5 ± 12.5 g/l, respectively, with a mean difference of 5.67 g/l (95% confidence interval: 5.45 to 5.90, P<0.001); which is equivalent to 0.567 g%. The prevalence of anaemia was reported as 59.6 and 78.2 per cent by direct and indirect methods, respectively. Sensitivity and specificity of indirect cyanmethaemoglobin method were 99.2 and 56.4 per cent, respectively. Using regression analysis, prediction equation was developed for indirect haemoglobin values. Interpretation & conclusions: The present findings revealed that indirect cyanmethaemoglobin method overestimated the prevalence of anaemia as compared to the direct method. However, if a correction factor is applied, indirect method could be successfully used for estimating true haemoglobin level. More studies should be undertaken to establish agreement and correction factor between direct and indirect cyanmethaemoglobin methods. PMID:28256465

  1. Electron beam focusing system

    SciTech Connect

    Dikansky, N.; Nagaitsev, S.; Parkhomchuk, V.

    1997-09-01

    The high energy electron cooling requires a very cold electron beam. Thus, the electron beam focusing system is very important for the performance of electron cooling. A system with and without longitudinal magnetic field is presented for discussion. Interaction of electron beam with the vacuum chamber as well as with the background ions and stored antiprotons can cause the coherent electron beam instabilities. Focusing system requirements needed to suppress these instabilities are presented.

  2. High harmonics focusing undulator

    SciTech Connect

    Varfolomeev, A.A.; Hairetdinov, A.H.; Smirnov, A.V.; Khlebnikov, A.S.

    1995-12-31

    It was shown in our previous work that there exist a possibility to enhance significantly the {open_quote}natural{close_quote} focusing properties of the hybrid undulator. Here we analyze the actual undulator configurations which could provide such field structure. Numerical simulations using 2D code PANDIRA were carried out and the enhanced focusing properties of the undulator were demonstrated. The obtained results provide the solution for the beam transport in a very long (short wavelength) undulator schemes.

  3. New NLC Final Focus

    SciTech Connect

    Raimondi, P.

    2004-10-11

    A novel design of the Final Focus has recently been proposed [1] and has been adopted now for the Next Linear Collider [2]. This new design has fewer optical elements and is much shorter, nonetheless achieving better chromatic properties. In this paper, the new final focus system is briefly discussed stressing one particular characteristic of the new design--its multi TeV energy reach.

  4. Restoration of extensive erosion areas using an indirect composite technique.

    PubMed

    Knight, J S; Sneed, W D

    2000-01-01

    Cervical erosion defects, particularly those of extensive size that are located in an area where control of the operative field is difficult, can present a significant restorative challenge. This article describes an indirect restorative technique to solve this problem. Following tooth preparation, an indirect restoration is luted to the tooth and the margins are finished and polished. Using an indirect technique minimizes operative field isolation time and the total chairside time required to restore the tooth. Clinical cases are presented to illustrate this technique.

  5. Percent relative cumulative frequency analysis in indirect calorimetry: application to studies of transgenic mice.

    PubMed

    Riachi, Marc; Himms-Hagen, Jean; Harper, Mary-Ellen

    2004-12-01

    Indirect calorimetry is commonly used in research and clinical settings to assess characteristics of energy expenditure. Respiration chambers in indirect calorimetry allow measurements over long periods of time (e.g., hours to days) and thus the collection of large sets of data. Current methods of data analysis usually involve the extraction of only a selected small proportion of data, most commonly the data that reflects resting metabolic rate. Here, we describe a simple quantitative approach for the analysis of large data sets that is capable of detecting small differences in energy metabolism. We refer to it as the percent relative cumulative frequency (PRCF) approach and have applied it to the study of uncoupling protein-1 (UCP1) deficient and control mice. The approach involves sorting data in ascending order, calculating their cumulative frequency, and expressing the frequencies in the form of percentile curves. Results demonstrate the sensitivity of the PRCF approach for analyses of oxygen consumption (.VO2) as well as respiratory exchange ratio data. Statistical comparisons of PRCF curves are based on the 50th percentile values and curve slopes (H values). The application of the PRCF approach revealed that energy expenditure in UCP1-deficient mice housed and studied at room temperature (24 degrees C) is on average 10% lower (p < 0.0001) than in littermate controls. The gradual acclimation of mice to 12 degrees C caused a near-doubling of .VO2 in both UCP1-deficient and control mice. At this lower environmental temperature, there were no differences in .VO2 between groups. The latter is likely due to augmented shivering thermogenesis in UCP1-deficient mice compared with controls. With the increased availability of murine models of metabolic disease, indirect calorimetry is increasingly used, and the PRCF approach provides a novel and powerful means for data analysis.

  6. Hydrodynamic focusing--a versatile tool.

    PubMed

    Golden, Joel P; Justin, Gusphyl A; Nasir, Mansoor; Ligler, Frances S

    2012-01-01

    The control of hydrodynamic focusing in a microchannel has inspired new approaches for microfluidic mixing, separations, sensors, cell analysis, and microfabrication. Achieving a flat interface between the focusing and focused fluids is dependent on Reynolds number and device geometry, and many hydrodynamic focusing systems can benefit from this understanding. For applications where a specific cross-sectional shape is desired for the focused flow, advection generated by grooved structures in the channel walls can be used to define the shape of the focused flow. Relative flow rates of the focused flow and focusing streams can be manipulated to control the cross-sectional area of the focused flows. This paper discusses the principles for defining the shape of the interface between the focused and focusing fluids and provides examples from our lab that use hydrodynamic focusing for impedance-based sensors, flow cytometry, and microfabrication to illustrate the breadth of opportunities for introducing new capabilities into microfluidic systems. We evaluate each example for the advantages and limitations integral to utilization of hydrodynamic focusing for that particular application.

  7. Research Focus. Section II.

    ERIC Educational Resources Information Center

    Atkins, Bobbie J.; And Others

    Five papers, discussing research on nonwhite disabled persons, were presented at a 1984 conference on the needs of this population. In "Innovative Approaches and Research in Addressing the Needs of Nonwhite Disabled Persons," B. J. Atkins examines counseling approaches and research needs. In "The Role of Social Support in Disease Severity in…

  8. EDITORIAL: Focus on Plasmonics FOCUS ON PLASMONICS

    NASA Astrophysics Data System (ADS)

    Bozhevolnyi, Sergey; García-Vidal, Francisco

    2008-10-01

    Plasmonics is an emerging field in optics dealing with the so-called surface plasmons whose extraordinary properties are being both analyzed from a fundamental point of view and exploited for numerous technological applications. Surface plasmons associated with surface electron density oscillations decorating metal-dielectric interfaces were discovered by Rufus Ritchie in the 1950s. Since the seventies, the subwavelength confinement of electromagnetic fields as well as their enhancement inherent to the surface plasmon excitation has been widely used for spectroscopic purposes. Recent advances in nano-fabrication, characterization and modelling techniques have allowed unique properties of these surface electromagnetic modes to be explored with respect to subwavelength field localization and waveguiding, opening the path to truly nanoscale plasmonic optical devices. This area of investigation also has interesting links with research on photonic band gap materials and the field of optical metamaterials. Nowadays, plasmonics can be seen as a mature interdisciplinary area of research in which scientists coming from different backgrounds (chemistry, physics, optics and engineering) strive to discover and exploit new and exciting phenomena associated with surface plasmons. The already made and forthcoming discoveries will have impacts in many fields of science and technology, including not only photonics and materials science but also computation, biology and medicine, among others. This focus issue of New Journal of Physics is intended to cover all the aforementioned capabilities of surface plasmons by presenting a current overview of state-of-the-art advances achieved by the leading groups in this field of research. The below list of articles represents the first contributions to the collection and further additions will appear soon. Focus on Plasmonics Contents Nanoantenna array-induced fluorescence enhancement and reduced lifetimes Reuben M Bakker, Vladimir P Drachev

  9. CCN Predictions: Is Theory Sufficient for Indirect Forcing Calculations?

    NASA Astrophysics Data System (ADS)

    Sotiropoulou, R. P.; Medina, J.; Nenes, A.

    2005-12-01

    There are numerous studies that assess the ability to predict ambient cloud condensation nuclei (CCN) concentrations from aerosol size and composition measurements. All conclude that predictions often are significantly different from observations (e.g. Martin et al., 1994; Liu et al., 1996; Roberts et al., 2002; VanReken et al., 2003). This discrepancy may arise from many factors, the most common identified is the inability of current theory to fully describe CCN activity. Despite this "CCN closure" problem, predicting cloud droplet number concentration (CDNC) from observations of cloud updraft velocity and aerosol size/composition has proven to be remarkably successful, even for cases where CCN predictions are known to be significantly different from measurements (Snider and Brenguier, 2000; Snider et al., 2003; Conant et al., 2004). Since GCM assessments of the aerosol indirect effect require accurate predictions of cloud droplet number, field studies may suggest that a relatively large error in CCN concentration may not necessarily yield large errors in CDNC. This study focuses on quantitatively assessing the sensitivity of cloud droplet number to errors in predicted CCN concentrations. For this we use ground-based CCN and aerosol measurements obtained during the ICARTT campaign (July-August 2004) at the UNH Thompson Farm site to produce "observed" and "calculated" CCN spectra. These spectra are then introduced into a parameterization of cloud droplet formation (Nenes and Seinfeld, 2003), where errors in CCN concentration (i.e., difference between "observed" and "calculated" CCN spectra) can directly be related to resulting cloud droplet number errors. This exercise is repeated for all the CCN spectra in the dataset and for a wide range of cloud updraft velocity; this allows for determining conditions for which large errors in CCN concentration do not yield significant errors in cloud droplet number (and vice versa).

  10. Direct and Indirect Phototransformation of Graphene Oxide in Sunlight

    EPA Science Inventory

    Direct and indirect (with added H202 that serves as OH precursor) photoreactions of grapheme oxide (GO) were examined under sunlight exposure. The results indicate that GO photoreacts under both conditions, leading to significant alterations in GO's physicochemical properties. In...

  11. Mechanical analysis of Drosophila indirect flight and jump muscles

    PubMed Central

    Swank, Douglas M.

    2011-01-01

    The genetic advantages of Drosophila make it a very appealing choice for investigating muscle development, muscle physiology and muscle protein structure and function. To take full advantage of this model organism, it has been vital to develop isolated Drosophila muscle preparations that can be mechanically evaluated. We describe techniques to isolate, prepare and mechanically analyze skinned muscle fibers from two Drosophila muscle types, the indirect flight muscle and the jump muscle. The function of the indirect flight muscle is similar to vertebrate cardiac muscle, to generate power in an oscillatory manner. The indirect flight muscle is ideal for evaluating the influence of protein mutations on muscle and cross-bridge stiffness, oscillatory power, and deriving cross-bridge rate constants. Jump muscle physiology and structure are more similar to skeletal vertebrate muscle than indirect flight muscle, and it is ideal for measuring maximum shortening velocity, force-velocity characteristics and steady-state power generation. PMID:22079350

  12. Indirect coupling between two cavity modes via ferromagnetic resonance

    NASA Astrophysics Data System (ADS)

    Hyde, Paul; Bai, Lihui; Harder, Michael; Match, Christophe; Hu, Can-Ming

    2016-10-01

    We experimentally realize an indirect coupling between two cavity modes via strong coupling with ferromagnetic resonance in Yttrium Iron Garnet. We find that some indirectly coupled modes of this system can have a higher microwave transmission than the individual uncoupled modes. Using a coupled harmonic oscillator model, the influence of the oscillation phase difference between the two cavity modes on the nature of the indirect coupling is revealed. The properties of the indirectly coupled modes can be controlled using an external magnetic field or by tuning the cavity height. The relation between cavity transmission and the relative phase difference between cavity modes should be useful for developing tunable optical devices and improved information processing technologies.

  13. 48 CFR 2052.216-71 - Indirect cost rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: * *To be incorporated into any resultant contract. (End of clause) Alternate 2 (OCT 1999). As prescribed... (OCT 1999) (a) For this contract, the ceiling amount reimbursable for indirect costs is as...

  14. Indirect effects by meningococcal vaccines: herd protection versus herd immunity.

    PubMed

    Bröker, Michael

    2011-08-01

    The term "herd immunity" for the indirect effect of meningococcal conjugate vaccines is inaccurate. A more appropriate term is "herd protection," because this term correctly describes the public effects imparted by vaccination campaigns against the meningococcus.

  15. NICMOS focus monitor

    NASA Astrophysics Data System (ADS)

    Schneider, Glenn

    1997-07-01

    This proposal is used to determine and monitor the optimal focus and tilt settings for all three NICMOS cameras. It is derived from SM2/NIC 7041, but is structurally quite a bit different. This proposal is built to run NIC1/2 focus sweeps on a weekly basis, and NIC3 focus sweeps twice a week during SMOV {following the "interim" runs of the 7150}. 7043 will run for as long as it is deemed necessary to keep track of the camera focii and to monitor the dewar anomaly. After the discussion on 20/3/96, this proposal is written to run 4 complete 1-week iterations starting 3 days after the last run of the 7150 {NICMOS COARSE OPTICAL ALIGNMENT, PART 2}.

  16. Sagittal focusing Laue monochromator

    DOEpatents

    Zhong; Zhong , Hanson; Jonathan , Hastings; Jerome , Kao; Chi-Chang , Lenhard; Anthony , Siddons; David Peter , Zhong; Hui

    2009-03-24

    An x-ray focusing device generally includes a slide pivotable about a pivot point defined at a forward end thereof, a rail unit fixed with respect to the pivotable slide, a forward crystal for focusing x-rays disposed at the forward end of the pivotable slide and a rearward crystal for focusing x-rays movably coupled to the pivotable slide and the fixed rail unit at a distance rearward from the forward crystal. The forward and rearward crystals define reciprocal angles of incidence with respect to the pivot point, wherein pivoting of the slide about the pivot point changes the incidence angles of the forward and rearward crystals while simultaneously changing the distance between the forward and rearward crystals.

  17. Capturing the Future: Direct and Indirect Probes of Neutron Capture

    SciTech Connect

    Couture, Aaron Joseph

    2016-08-31

    This report documents aspects of direct and indirect neutron capture. The importance of neutron capture rates and methods to determine them are presented. The following conclusions are drawn: direct neutron capture measurements remain a backbone of experimental study; work is being done to take increased advantage of indirect methods for neutron capture; both instrumentation and facilities are making new measurements possible; more work is needed on the nuclear theory side to understand what is needed furthest from stability.

  18. Cementation of indirect restorations: an overview of resin cements.

    PubMed

    Stamatacos, Catherine; Simon, James F

    2013-01-01

    The process of ensuring proper retention, marginal seal, and durability of indirect restorations depends heavily on effective cementation. Careful consideration must be made when selecting an adhesive cement for a given application. This article provides information on resin cements that can guide clinicians in determining which type of cement is best suited to their clinical needs regarding cementation of indirect restorations. Emphasis is placed on successful cementation of all-ceramic restorations.

  19. [Focused musculoskeletal sonography].

    PubMed

    Horn, Rudolf

    2015-09-16

    Even in emergent situations, focused musculoskeletal sonography must not be overlooked. It has a place in traumatology no less valuable than its place in internal medicine. It can be used to identify traumatic joint effusions, occult fractures and fissures, joint inflammation, muscle and tendon rupture; it can differentiate soft tissue swelling, locate a foreign body, or identify the location of fractures. Focused ultrasound should be performed by the attending physician directly at the patient’s bedside, in order to answer these specific questions.

  20. Electrolysis and isoelectric focusing

    NASA Astrophysics Data System (ADS)

    Choi, Y. S.; Lui, Roger; Yu, Xun

    1994-01-01

    This paper consists of two parts. In the first part, the authors prove the existence of steady-state solutions for a three-species electrolyte. The species are subject to both dissociation-association reactions inside the electrolyte and electrochemical reactions at the boundary electrodes. This is a common occurrence in electrolysis. In the second part, the authors investigate how to use this model to describe isoelectric focusing, which is a common technique used to separate large protein molecules. In particular, the isoelectric focusing point for a particular type of protein molecule is calculated using formal perturbation analysis.