Hydrostatigraphic characterization of coastal aquifer by geophysical log analysis, Cape Cod National Seashore, Massachusetts

USGS Publications Warehouse

Morin, Roger H.; Urish, Daniel W.

1995-01-01

The Cape Cod National Seashore comprises part of Provincetown, Massachusetts, which lies at the northern tip of Cape Cod. The hydrologic regime in this area consists of unconsolidated sand-and-gravel deposits that constitute a highly permeable aquifer within which is a freshwater lens floating on denser sea water. A network of wells was installed into this aquifer to monitor a leachate plume emanating from the Provincetown landfill. Wells were located along orthogonal transects perpendicular to and parallel to the general groundwater flow path from the landfill to the seashore approximately 1,000 m to the southeast. Temperature, epithermal neutron, natural gamma. and electronmagnetic induction logs were obtained in five wells to depths ranging from 23 to 37 m. These logs identify the primary contamination and show that its movement is controlled by and confined within a dominant hydrostratigraphic unit about 2 to 5 m thick that exhibits low porosity, large representative grain size, and high relative permeability. A relation is also found between the temperaturegradient logs and water quality, with the gradient traces serving as effective delineators of the contaminant plume in wells nearest the landfill. Contamination is not detectable in the well nearest the seashore and farthest from the landfill, and the induction log from this well clearly identifies the freshwater/seawater transition zone at a depth of about 18 m. The geophysical logs provide fundamental information concerning the spatial distribution of aquifer properties near the landfill and lend valuable insight into how these properties influence the migration of the leachate plume to the sea.

Geophysical, stratigraphic, and flow-zone logs of selected test, monitor, and water-supply wells in Cayuga County, New York

USGS Publications Warehouse

Anderson, J. Alton; Williams, John H.; Eckhardt, David A.V.; Miller, Todd S.

2003-01-01

Volatile-organic compounds have been detected in water sampled from more than 50 supply wells between the City of Auburn and Village of Union Springs in Cayuga County, New York, and the area was declared a Superfund site in 2002. In 2001-04, geophysical logs were collected from 37 test, monitor, and water-supply wells as a preliminary part of the investigation of volatile-organic compound contamination in the carbonate-bedrock aquifer system. The geophysical logs included gamma, induction, caliper, wellbore image, deviation, fluid resistivity and temperature, and flowmeter. The geophysical logs were analyzed along with core samples and outcrops of the bedrock to define the stratigraphic units and flow zones penetrated by the wells. This report describes the logging methods used in the study and presents the geophysical, stratigraphic, and flow-zone logs.

On coincident loop transient electromagnetic induction logging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swidinsky, Andrei; Weiss, Chester J.

Coincident loop transient induction wireline logging is examined as the borehole analog of the well-known land and airborne time-domain electromagnetic (EM) method. The concept of whole-space late-time apparent resistivity is modified from the half-space version commonly used in land and airborne geophysics and applied to the coincident loop voltages produced from various formation, borehole, and invasion models. Given typical tool diameters, off-time measurements with such an instrument must be made on the order of nanoseconds to microseconds — much more rapidly than for surface methods. Departure curves of the apparent resistivity for thin beds, calculated using an algorithm developed tomore » model the transient response of a loop in a multilayered earth, indicate that the depth of investigation scales with the bed thickness. Modeled resistivity logs are comparable in accuracy and resolution with standard frequency-domain focused induction logs. However, if measurement times are longer than a few microseconds, the thicknesses of conductors can be overestimated, whereas resistors are underestimated. Thin-bed resolution characteristics are explained by visualizing snapshots of the EM fields in the formation, where a conductor traps the electric field while two current maxima are produced in the shoulder beds surrounding a resistor. Radial profiling is studied using a concentric cylinder earth model. Results found that true formation resistivity can be determined in the presence of either oil- or water-based mud, although in the latter case, measurements must be taken several orders of magnitude later in time. Lastly, the ability to determine true formation resistivity is governed by the degree that the EM field heals after being distorted by borehole fluid and invasion, a process visualized and particularly evident in the case of conductive water-based mud.« less

On coincident loop transient electromagnetic induction logging

DOE PAGES

Swidinsky, Andrei; Weiss, Chester J.

2017-05-31

Coincident loop transient induction wireline logging is examined as the borehole analog of the well-known land and airborne time-domain electromagnetic (EM) method. The concept of whole-space late-time apparent resistivity is modified from the half-space version commonly used in land and airborne geophysics and applied to the coincident loop voltages produced from various formation, borehole, and invasion models. Given typical tool diameters, off-time measurements with such an instrument must be made on the order of nanoseconds to microseconds — much more rapidly than for surface methods. Departure curves of the apparent resistivity for thin beds, calculated using an algorithm developed tomore » model the transient response of a loop in a multilayered earth, indicate that the depth of investigation scales with the bed thickness. Modeled resistivity logs are comparable in accuracy and resolution with standard frequency-domain focused induction logs. However, if measurement times are longer than a few microseconds, the thicknesses of conductors can be overestimated, whereas resistors are underestimated. Thin-bed resolution characteristics are explained by visualizing snapshots of the EM fields in the formation, where a conductor traps the electric field while two current maxima are produced in the shoulder beds surrounding a resistor. Radial profiling is studied using a concentric cylinder earth model. Results found that true formation resistivity can be determined in the presence of either oil- or water-based mud, although in the latter case, measurements must be taken several orders of magnitude later in time. Lastly, the ability to determine true formation resistivity is governed by the degree that the EM field heals after being distorted by borehole fluid and invasion, a process visualized and particularly evident in the case of conductive water-based mud.« less

The influence of topology on hydraulic conductivity in a sand-and-gravel aquifer.

PubMed

Morin, Roger H; LeBlanc, Denis R; Troutman, Brent M

2010-01-01

A field experiment consisting of geophysical logging and tracer testing was conducted in a single well that penetrated a sand-and-gravel aquifer at the U.S. Geological Survey Toxic Substances Hydrology research site on Cape Cod, Massachusetts. Geophysical logs and flowmeter/pumping measurements were obtained to estimate vertical profiles of porosity phi, hydraulic conductivity K, temperature, and bulk electrical conductivity under background, freshwater conditions. Saline-tracer fluid was then injected into the well for 2 h and its radial migration into the surrounding deposits was monitored by recording an electromagnetic-induction log every 10 min. The field data are analyzed and interpreted primarily through the use of Archie's (1942) law to investigate the role of topological factors such as pore geometry and connectivity, and grain size and packing configuration in regulating fluid flow through these coarse-grained materials. The logs reveal no significant correlation between K and phi, and imply that groundwater models that link these two properties may not be useful at this site. Rather, it is the distribution and connectivity of the fluid phase as defined by formation factor F, cementation index m, and tortuosity alpha that primarily control the hydraulic conductivity. Results show that F correlates well with K, thereby indicating that induction logs provide qualitative information on the distribution of hydraulic conductivity. A comparison of alpha, which incorporates porosity data, with K produces only a slightly better correlation and further emphasizes the weak influence of the bulk value of varphi on K.

Data for four geologic test holes in the Sacramento Valley, California

USGS Publications Warehouse

Berkstresser, C.F.; French, J.J.; Schaal, M.E.

1985-01-01

The report provides geological and geophysical data for four of seven test holes drilled as a part of the Central Valley Aquifer Project, which is part of the Regional Aquifer Systems Analysis. The holes were drilled with a rotary well drilling machine to depths of 900 feet in the southwestern part of the Sacramento Valley in Solano and Yolo Counties. Geologic data for each well include lithology, texture, color, character of the contact, sorting, rounding, and cementation, determined from cuttings, cores, and sidewall covers. Fifty cores, 3 feet long, were obtained from each hole, and from eight to fourteen sidewall cores were collected. Geophysical data include a dual-induction log, spherically focused log (SFL), compensated neutron-formation density log, gamma-ray log, and a caliper log. These data are presented in four tables and on four plates. (USGS)

The thermal maturation degree of organic matter from source rocks revealed by wells logs including examples from Murzuk Basin, Libya

DOE Office of Scientific and Technical Information (OSTI.GOV)

Negoita, V.; Gheorghe, A.

1995-08-01

The customary technique used to know the organic matter quantity per rock volume it as well as the organic matter maturation stage is based on geochemical analyses accomplished on a preselected number of samples and cuttings drawn from boreholes during the drilling period. But the same objectives can be approached without any extra cost using the continuous measurements of well logs recorded in each well from the ground surface to the total depth. During the diagenetic stage, the identification of potential source rocks out of which no hydrocarbon have been generated may be carried out using a well logging suitemore » including Gamma Ray Spectrometry, the Compensated Neutron/Litho Density combination and a Dual Induction/Sonic Log. During the catagenetic stage the onset of oil generation brings some important changes in the organic matter structure as well as in the fluid distribution throughout the pore space of source rocks. The replacement of electric conductive water by electric non-conductive hydrocarbons, together with water and oil being expelled from source rocks represent a process of different intensities dependent of time/temperature geohistory and kerogen type. The different generation and expulsion scenarios of hydrocarbons taking place during the catagenetic and metagenetic stages of source rocks are very well revealed by Induction and Laterolog investigations. Several crossplots relating vitrinite reflectance, total organic carbon and log-derived physical parameters are illustrated and discussed. The field applications are coming from Murzuk Basin, where Rompetrol of Libya is operating.« less

The influence of topology on hydraulic conductivity in a sand-and-gravel aquifer

USGS Publications Warehouse

Morin, Roger H.; LeBlanc, Denis R.; Troutman, Brent M.

2010-01-01

A field experiment consisting of geophysical logging and tracer testing was conducted in a single well that penetrated a sand-and-gravel aquifer at the U.S. Geological Survey Toxic Substances Hydrology research site on Cape Cod, Massachusetts. Geophysical logs and flowmeter/pumping measurements were obtained to estimate vertical profiles of porosity ϕ, hydraulic conductivity K, temperature, and bulk electrical conductivity under background, freshwater conditions. Saline-tracer fluid was then injected into the well for 2 h and its radial migration into the surrounding deposits was monitored by recording an electromagnetic-induction log every 10 min. The field data are analyzed and interpreted primarily through the use of Archie's (1942) law to investigate the role of topological factors such as pore geometry and connectivity, and grain size and packing configuration in regulating fluid flow through these coarse-grained materials. The logs reveal no significant correlation between K and ϕ, and imply that groundwater models that link these two properties may not be useful at this site. Rather, it is the distribution and connectivity of the fluid phase as defined by formation factor F, cementation index m, and tortuosity α that primarily control the hydraulic conductivity. Results show that F correlates well with K, thereby indicating that induction logs provide qualitative information on the distribution of hydraulic conductivity. A comparison of α, which incorporates porosity data, with K produces only a slightly better correlation and further emphasizes the weak influence of the bulk value of ϕ on K.

The influence of topology on hydraulic conductivity in a sand-and-gravel aquifer

USGS Publications Warehouse

Morin, R.H.; LeBlanc, D.R.; Troutman, B.M.

2010-01-01

A field experiment consisting of geophysical logging and tracer testing was conducted in a single well that penetrated a sand-and-gravel aquifer at the U.S. Geological Survey Toxic Substances Hydrology research site on Cape Cod, Massachusetts. Geophysical logs and flowmeter/pumping measurements were obtained to estimate vertical profiles of porosity ??, hydraulic conductivity K, temperature, and bulk electrical conductivity under background, freshwater conditions. Saline-tracer fluid was then injected into the well for 2 h and its radial migration into the surrounding deposits was monitored by recording an electromagnetic-induction log every 10 min. The field data are analyzed and interpreted primarily through the use of Archie's (1942) law to investigate the role of topological factors such as pore geometry and connectivity, and grain size and packing configuration in regulating fluid flow through these coarse-grained materials. The logs reveal no significant correlation between K and ??, and imply that groundwater models that link these two properties may not be useful at this site. Rather, it is the distribution and connectivity of the fluid phase as defined by formation factor F, cementation index m, and tortuosity ?? that primarily control the hydraulic conductivity. Results show that F correlates well with K, thereby indicating that induction logs provide qualitative information on the distribution of hydraulic conductivity. A comparison of ??, which incorporates porosity data, with K produces only a slightly better correlation and further emphasizes the weak influence of the bulk value of ?? on K. Copyright ?? 2009 The Author(s) are Federal Government Employees. Journal compilation ?? 2009 National Ground Water Association.

Response simulation and theoretical calibration of a dual-induction resistivity LWD tool

NASA Astrophysics Data System (ADS)

Xu, Wei; Ke, Shi-Zhen; Li, An-Zong; Chen, Peng; Zhu, Jun; Zhang, Wei

2014-03-01

In this paper, responses of a new dual-induction resistivity logging-while-drilling (LWD) tool in 3D inhomogeneous formation models are simulated by the vector finite element method (VFEM), the influences of the borehole, invaded zone, surrounding strata, and tool eccentricity are analyzed, and calibration loop parameters and calibration coefficients of the LWD tool are discussed. The results show that the tool has a greater depth of investigation than that of the existing electromagnetic propagation LWD tools and is more sensitive to azimuthal conductivity. Both deep and medium induction responses have linear relationships with the formation conductivity, considering optimal calibration loop parameters and calibration coefficients. Due to the different depths of investigation and resolution, deep induction and medium induction are affected differently by the formation model parameters, thereby having different correction factors. The simulation results can provide theoretical references for the research and interpretation of the dual-induction resistivity LWD tools.

Technical data on new engineering products

NASA Astrophysics Data System (ADS)

1985-02-01

New grades of permanently magnetic materials; automatic digital radiolocator; bench winder; analog induction gauge; programmable pulse generator; portable defibrillators; pipe welders; two-component electromagnetic log; sulphur content analyzer; peristaltic pumps; function generators; welding manipulator; and tonsiometer are described.

Bias in ground-water data caused by well-bore flow in long-screen wells

USGS Publications Warehouse

Church, P.E.; Granato, G.E.

1996-01-01

The results of a field experiment comparing water-quality constituents, specific conductance, geophysical measurements, and well-bore hydraulics in two long-screen wells and adjacent vertical clusters of short-screen wells show bias in ground-water data caused by well-bore flow in long-screen wells. The well screen acts as a conduit for vertical flow because it connects zones of different head and transmissivity, even in a relatively homogeneous, unconfined, sand and gravel aquifer where such zones are almost indistinguishable. Flow in the well bore redistributes water and solutes in the aquifer adjacent to the well, increasing the risk of bias in water-quality samples, failure of plume detection, and cross-contamination of the aquifer. At one site, downward flow from a contaminated zone redistributes solutes over the entire length of the long-screen well. At another site, upward flow from an uncontaminated zone masks the presence of road salt plume. Borehole induction logs, conducted in a fully penetrating short-screen well, can provide a profile of solutes in the aquifer that is not attainable in long-screen wells. In this study, the induction-log profiles show close correlation with data from analyses of water-quality samples from the short-screen wells; however, both of these data sets differ markedly from the biased water-quality samples from the long-screen wells. Therefore, use of induction logs in fully cased wells for plume detection and accurate placement of short-screen wells is a viable alternative to use of long screen wells for water-quality sampling.

Induction logging device

DOEpatents

Koelle, A.R.; Landt, J.A.

An instrument is disclosed for mapping vertical conductive fractures in a resistive bedrock, magnetically inducing eddy currents by a pair of vertically oriented, mutually perpendicular, coplanar coils. The eddy currents drive magnetic fields which are picked up by a second, similar pair of coils.

Detailed evaluation of gas hydrate reservoir properties using JAPEX/JNOC/GSC Mallik 2L-38 gas hydrate research well downhole well-log displays

USGS Publications Warehouse

Collett, T.S.

1999-01-01

The JAPEX/JNOC/GSC Mallik 2L-38 gas hydrate research well project was designed to investigate the occurrence of in situ natural gas hydrate in the Mallik area of the Mackenzie Delta of Canada. Because gas hydrate is unstable at surface pressure and temperature conditions, a major emphasis was placed on the downhole logging program to determine the in situ physical properties of the gas-hydrate-bearing sediments. Downhole logging tool strings deployed in the Mallik 2L-38 well included the Schlumberger Platform Express with a high resolution laterolog, Array Induction Imager Tool, Dipole Shear Sonic Imager, and a Fullbore Formation Microlmager. The downhole log data obtained from the log- and core-inferred gas-hydrate-bearing sedimentary interval (897.25-1109.5 m log depth) in the Mallik 2L-38 well is depicted in a series of well displays. Also shown are numerous reservoir parameters, including gas hydrate saturation and sediment porosity log traces, calculated from available downhole well-log and core data. The gas hydrate accumulation delineated by the Mallik 2L-38 well has been determined to contain as much as 4.15109 m3 of gas in the 1 km2 area surrounding the drill site.

Comparative molecular field analysis to derive pharmacophore maps for induction doses of intravenous anaesthetic agents.

PubMed

Sear, J W

2011-03-01

The present study examines the molecular basis of induction of anaesthesia by i.v. hypnotic agents using comparative molecular field analysis (CoMFA). ED(50) induction doses for 14 i.v. anaesthetics in human subjects (expressed as molar dose per kilogram body weight) were obtained from the literature. Immobilizing potency data for the same 14 agents (expressed as the EC(50) plasma free drug concentrations that abolish movement in response to a noxious stimulus in 50% patients) were taken from our previous publication. These data were used to form CoMFA models for the two aspects of anaesthetic activity. Molecular alignment was achieved by field-fit minimization techniques. The lead structure for both models was eltanolone. The final CoMFA model for the ED(50) induction dose was based on two latent variables, and explained 99.3% of the variance in observed activities. It showed good intrinsic predictability (cross-validated q(2)=0.849). The equivalent model for immobilizing activity was also based on two latent variables, with r(2)=0.988 and q(2)=0.852. Although there was a correlation between -log ED(50) and -log EC(50) (r(2)=0.779), comparison of the pharmacophore maps showed poor correlation for both electrostatic and steric regions when isocontours were constructed by linking lattice grid points, making the greatest 40% contributions; the relative contributions of electrostatic and steric interactions differing between the models (induction dose: 2.5:1; immobilizing activity 1.8:1). Comparison of two CoMFA activity models shows only small elements of commonality, suggesting that different molecular features may be responsible for these two properties of i.v. anaesthetics.

Induction logging device with a pair of mutually perpendicular bucking coils

DOEpatents

Koelle, Alfred R.; Landt, Jeremy A.

1981-01-01

An instrument is disclosed for mapping vertical conductive fractures in a resistive bedrock, magnetically inducing eddy currents by a pair of vertically oriented, mutually perpendicular, coplanar coils. The eddy currents drive magnetic fields which are picked up by a second, similar pair of coils.

Non-contact electromagnetic induction heating for eradicating bacteria and yeasts on biomaterials and possible relevance to orthopaedic implant infections: In vitro findings.

PubMed

Pijls, B G; Sanders, I M J G; Kuijper, E J; Nelissen, R G H H

2017-05-01

Infection of implants is a major problem in elective and trauma surgery. Heating is an effective way to reduce the bacterial load in food preparation, and studies on hyperthermia treatment for cancer have shown that it is possible to heat metal objects with pulsed electromagnetic fields selectively (PEMF), also known as induction heating. We therefore set out to answer the following research question: is non-contact induction heating of metallic implants effective in reducing bacterial load in vitro ? Titanium alloy cylinders (Ti6Al4V) were exposed to PEMF from an induction heater with maximum 2000 watts at 27 kHz after being contaminated with five different types of micro-organisms: Staphylococcus epidermidis; Staphylococcus aureus; Pseudomonas aeruginosa ; spore-forming Bacillus cereus; and yeast Candida albicans . The cylinders were exposed to incremental target temperatures (35°C, 45°C, 50°C, 55°C, 60°C, 65°C, 70°C) for up to 3.5 minutes. There was an average linear heating rate of 0.39°C per second up to the target temperature, and thereafter the target temperature was maintained until the end of the experiment. At 60°C and higher (duration 3.5 minutes), there was a 6-log reduction or higher for every micro-organism tested. At 60°C, we found that the shortest duration of effective induction heating was 1.5 minutes. This resulted in a 5-log reduction or higher for every micro-organism tested. Non-contact induction heating of a titanium disk is effective in reducing bacterial load in vitro . These promising results can be further explored as a new treatment modality for infections of metal orthopaedic implants. Cite this article : B. G. Pijls, I. M. J. G. Sanders, E. J. Kuijper, R. G. H. H. Nelissen. Non-contact electromagnetic induction heating for eradicating bacteria and yeasts on biomaterials and possible relevance to orthopaedic implant infections: In vitro findings. Bone Joint Res 2017;6:323-330. DOI: 10.1302/2046-3758.65.BJR-2016-0308.R1. © 2017 Pijls et al.

Preliminary report on geophysical well-logging activity on the Salton Sea Scientific Drilling Project, Imperial Valley, California

USGS Publications Warehouse

Paillet, Frederick L.; Morin, R.H.; Hodges, H.E.

1986-01-01

The Salton Sea Scientific Drilling Project has culminated in a 10,564-ft deep test well, State 2-14 well, in the Imperial Valley of southern California. A comprehensive scientific program of drilling, coring, and downhole measurements, which was conducted for about 5 months, has obtained much scientific information concerning the physical and chemical processes associated with an active hydrothermal system. This report primarily focuses on the geophysical logging activities at the State 2-14 well and provides early dissemination of geophysical data to other investigators working on complementary studies. Geophysical-log data were obtained by a commercial logging company and by the U.S. Geological Survey (USGS). Most of the commercial logs were obtained during three visits to the site; only one commercial log was obtained below a depth of 6,000 ft. The commercial logs obtained were dual induction, natural gamma, compensated neutron formation density, caliper and sonic. The USGS logging effort consisted of four primary periods, with many logs extending below a depth of 6,000 ft. The USGS logs obtained were temperature, caliper, natural gamma, gamma spectral, epithermal neutron, acoustic velocity, full-waveform, and acoustic televiewer. Various problems occurred throughout the drilling phase of the Salton Sea Scientific Drilling Project that made successful logging difficult: (1) borehole constrictions, possibly resulting from mud coagulation, (2) maximum temperatures of about 300 C, and (3) borehole conditions unfavorable for logging because of numerous zones of fluid loss, cement plugs, and damage caused by repeated trips in and out of the hole. These factors hampered and compromised logging quality at several open-hole intervals. The quality of the logs was dependent on the degree of probe sophistication and sensitivity to borehole-wall conditions. Digitized logs presented were processed on site and are presented in increments of 1,000 ft. A summary of the numerous factors that may be relevant to this interpretation also is presented. (Lantz-PTT)

Delineation of salt water intrusion through use of electromagnetic-induction logging: A case study in Southern Manhattan Island, New York

USGS Publications Warehouse

Stumm, Frederick; Como, Michael D.

2017-01-01

Groundwater with chloride concentrations up to 15,000 mg/L has intruded the freshwater aquifer underlying southern Manhattan Island, New York. Historical (1940–1950) chloride concentration data of glacial aquifer wells in the study area indicate the presence of four wedges of saltwater intrusion that may have been caused by industrial pumpage. The limited recharge capability of the aquifer, due to impervious surfaces and the 22.7 million liters per day (mld) of reported industrial pumpage early in the 20th Century was probably the cause for the saltwater intrusion and the persistence of the historical saltwater intrusion wedges over time. Recent drilling of wells provided new information on the hydrogeology and extent of saltwater intrusion of the glacial aquifer overlying bedrock. The new observation wells provided ground-water level, chloride concentration, hydraulic conductivity, and borehole geophysical data of the glacial aquifer. The glacial sediments range in thickness from less than 0.3 m to more than 76.2 m within the study area. A linear relation between Electromagnetic-induction (EM) conductivity log response and measured chloride concentration was determined. Using this relation, chloride concentration was estimated in parts of the glacial aquifer where sampling was not possible. EM logging is an effective tool to monitor changes in saltwater intrusion wedges.

Induction of Larval Settlement in the Reef Coral Porites astreoides by a Cultivated Marine Roseobacter Strain.

PubMed

Sharp, K H; Sneed, J M; Ritchie, K B; Mcdaniel, L; Paul, V J

2015-04-01

Successful larval settlement and recruitment by corals is critical for the survival of coral reef ecosystems. Several closely related strains of γ-proteobacteria have been identified as cues for coral larval settlement, but the inductive properties of other bacterial taxa naturally occurring in reef ecosystems have not yet been explored. In this study, we assayed bacterial strains representing taxonomic groups consistently detected in corals for their ability to influence larval settlement in the coral Porites astreoides. We identified one α-proteobacterial strain, Roseivivax sp. 46E8, which significantly increased larval settlement in P. astreoides. Logarithmic growth phase (log phase) cell cultures of Roseivivax sp. 46E8 and filtrates (0.22μm) from log phase Roseivivax sp. 46E8 cultures significantly increased settlement, suggesting that an extracellular settlement factor is produced during active growth phase. Filtrates from log phase cultures of two other bacterial isolates, Marinobacter sp. 46E3, and Cytophaga sp. 46B6, also significantly increased settlement, but the cell cultures themselves did not. Monospecific biofilms of the three strains did not result in significant increases in larval settlement. Organic and aqueous/methanol extracts of Roseivivax sp. 46E8 cultures did not affect larval settlement. Examination of filtrates from cell cultures showed that Roseivivax sp. 46E8 spontaneously generated virus-like particles in log and stationary phase growth. Though the mechanism of settlement enhancement by Roseivivax sp. 46E8 is not yet elucidated, our findings point to a new aspect of coral-Roseobacter interactions that should be further investigated, especially in naturally occurring, complex microbial biofilms on reef surfaces. © 2015 Marine Biological Laboratory.

Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.

PubMed

Jourdan, Eric; Boissel, Nicolas; Chevret, Sylvie; Delabesse, Eric; Renneville, Aline; Cornillet, Pascale; Blanchet, Odile; Cayuela, Jean-Michel; Recher, Christian; Raffoux, Emmanuel; Delaunay, Jacques; Pigneux, Arnaud; Bulabois, Claude-Eric; Berthon, Céline; Pautas, Cécile; Vey, Norbert; Lioure, Bruno; Thomas, Xavier; Luquet, Isabelle; Terré, Christine; Guardiola, Philippe; Béné, Marie C; Preudhomme, Claude; Ifrah, Norbert; Dombret, Hervé

2013-03-21

Not all patients with core binding factor acute myeloid leukemia (CBF-AML) display a good outcome. Modern risk factors include KIT and/or FLT3 gene mutations and minimal residual disease (MRD) levels, but their respective values have never been prospectively assessed. A total of 198 CBF-AML patients were randomized between a reinforced and a standard induction course, followed by 3 high-dose cytarabine consolidation courses. MRD levels were monitored prospectively. Gene mutations were screened at diagnosis. Despite a more rapid MRD decrease after reinforced induction, induction arm did not influence relapse-free survival (RFS) (64% in both arms; P = .91). Higher WBC, KIT, and/or FLT3-ITD/TKD gene mutations, and a less than 3-log MRD reduction after first consolidation, were associated with a higher specific hazard of relapse, but MRD remained the sole prognostic factor in multivariate analysis. At 36 months, cumulative incidence of relapse and RFS were 22% vs 54% (P < .001) and 73% vs 44% (P < .001) in patients who achieved 3-log MRD reduction vs the others. These results suggest that MRD, rather than gene mutations, should be used for future treatment stratifications in CBF-AML patients. This trial was registered at EudraCT as #2006-005163-26 and at www.clinicaltrials.gov as #NCT 00428558.

Demonstration of ROV-based Underwater Electromagnetic Array Technology

DTIC Science & Technology

2017-05-25

Volume Magnetic Source Model that Was Modified to Address EM Propagation through a Conductive Seawater Medium...16  Figure 7. Still Shots of the Integrated ROV- EM System (left) and the EM Sensor (right) Performing Bottom Following...of Defense DVL Doppler Velocity Log E Easting EOD Explosive Ordnance Disposal EM Electromagnetic EMI Electromagnetic Induction EMF

Multi-Sensor Systems Development for UXO Detection and Discrimination: Hand-Held Dual Magnetic/Electromagnetic Induction Sensor

DTIC Science & Technology

2008-04-01

5 Fluxgate magnetometer ... magnetometer into digital format, and transmitted as a single serial data string to log the Cs and fluxgate magnetometer data. After procurement...Hardware The system hardware comprises an EMI sensor, Cs vapor magnetometer , fluxgate magnetometer , hand-held data acquisition computer, integrated

Detection of contaminant plumes by bore­ hole geophysical logging

USGS Publications Warehouse

Mack, Thomas J.

1993-01-01

Two borehole geophysical methods—electromagnetic induction and natural gamma radiation logs—were used to vertically delineate landfill leachate plumes in a glacial aquifer. Geophysical logs of monitoring wells near two land-fills in a glacial aquifer in west-central Vermont show that borehole geophysical methods can aid in interpretation of geologic logs and placement of monitoring well screens to sample landfill leachate plumes.Zones of high electrical conductance were delineated from the electromagnetic log in wells near two landfills. Some of these zones were found to correlate with silt and clay units on the basis of drilling and gamma logs. Monitoring wells were screened specifically in zones of high electrical conductivity that did not correlate to a silt or clay unit. Zones of high electrical conductivity that did not correlate to a silt or clay unit were caused by the presence of ground water with a high specific conductance, generally from 1000 to 2370 μS/cm (microsiemens per centimeter at 25 degrees Celsius). Ambient ground water in the study area has a specific conductance of approximately 200 to 400 μS/cm. Landfill leachate plumes were found to be approximately 5 to 20 feet thick and to be near the water table surface.

Electromagnetic mapping of buried paleochannels in eastern Abu Dhabi Emirate, U.A.E.

USGS Publications Warehouse

Fitterman, D.V.; Menges, C.M.; Al Kamali, A.M.; Essa, Jama F.

1991-01-01

Transient electromagnetic soundings and terrain conductivity meter measurements were used to map paleochannel geometry in the Al Jaww Plain of eastern Abu Dhabi Emirate, U.A.E. as part of an integrated hydrogeologic study of the Quaternary alluvial aquifer system. Initial interpretation of the data without benefit of well log information was able to map the depth to a conductive clay layer of Tertiary age that forms the base of the aquifer. Comparison of the results with induction logs reveals that a resistive zone exists that was incorporated into the interpretation and its lateral extent mapped with the transient electromagnetic sounding data. ?? 1991.

Borehole-geophysical investigation of the University of Connecticut landfill, Storrs, Connecticut

USGS Publications Warehouse

Johnson, Carole D.; Haeni, F.P.; Lane, John W.; White, Eric A.

2002-01-01

A borehole-geophysical investigation was conducted to help characterize the hydrogeology of the fractured-rock aquifer and the distribution of unconsolidated glacial deposits near the former landfill and chemical waste-disposal pits at the University of Connecticut in Storrs, Connecticut. Eight bedrock boreholes near the landfill and three abandoned domestic wells located nearby were logged using conventional and advanced borehole-geophysical methods from June to October 1999. The conventional geophysical-logging methods included caliper, gamma, fluid temperature, fluid resistivity, and electromagnetic induction. The advanced methods included deviation, optical and acoustic imaging of the borehole wall, heat-pulse flowmeter, and directional radar reflection. Twenty-one shallow piezometers (less than 50-feet deep) were logged with gamma and electromagnetic induction tools to delineate unconsolidated glacial deposits. Five additional shallow bedrock wells were logged with conventional video camera, caliper, electromagnetic induction, and fluid resistivity and temperature tools. The rock type, foliation, and fracturing of the site were characterized from high-resolution optical-televiewer (OTV) images of rocks penetrated by the boreholes. The rocks are interpreted as fine- to medium-grained quartz-feldspar-biotite-garnet gneiss and schist with local intrusions of quartz diorite and pegmatite and minor concentrations of sulfide mineralization similar to rocks described as the Bigelow Brook Formation on regional geologic maps. Layers containing high concentrations of sulfide minerals appear as high electrical conductivity zones on electromagnetic-induction and borehole-radar logs. Foliation in the rocks generally strikes to the northeast-southwest and dips to the west, consistent with local outcrop observations. The orientation of foliation and small-scale gneissic layering in the rocks, however, varies locally and with depth in some of the boreholes. In two of the boreholes, the foliation strikes predominantly to the northwest and dips to the northeast. Although small-scale faults and lithologic discontinuities were observed in the OTV data, no large-scale faults were observed that appear on regional geologic maps. Fractures were located and characterized through the use of conventional geophysical, OTV, acoustic-televiewer (ATV), and borehole-radar logs. The orientation of fractures varies considerably across the site; some fractures are parallel to the foliation, whereas others cross-cut the foliation. Many of the transmissive fractures in the bedrock boreholes strike about N170?E and N320?E with dips of less than 45?. Other transmissive fractures strike about N60?E with dips of more than 60?. Most of the transmissive fractures in the domestic wells strike about N60?E and N22?E with dips of more than 45?. The strike of N60?E is parallel to the trend of a thrust fault that appears on regional geologic maps. Vertical flow in the boreholes was measured with the heat-pulse flowmeter under ambient and (or) pumping conditions. Results of ATV, OTV, and conventional logs were used to locate specific zones for flowmeter testing. Ambient downflow was measured in three boreholes, ambient upflow was measured in two other boreholes, and both ambient downflow and upflow were measured in a sixth borehole. The other five bedrock boreholes and domestic wells did not have measurable vertical flow. The highest rate of ambient flow was measured in the background borehole in which upflow and downflow converged and exited the borehole at a fracture zone near a depth of 62 feet. Ambient flow of about 340 gallons per day was measured. In the other five wells, ambient flow of about 20 to 35 gallons per day was measured. Under low-rate pumping (0.25 to 1 gallon per minute), one to six inflow zones were identified in each well. Usually the fractures that are active under ambient conditions contribute to the well under pumping conditions. To prevent

Investigation of origin for seawater intrusion using geophysical well logs and absolute ages of volcanic cores in the eastern part of Jeju Island

NASA Astrophysics Data System (ADS)

Hwang, Seho; Shin, Jehyun

2010-05-01

Jeju located in the southern extremity of Korea is volcanic island, one of best-known tourist attractions in Korea. Jeju Province operates the monitoring boreholes for the evaluation of groundwater resources in coastal area. Major rock types identified from drill cores are trachybasalt, acicular basalt, scoria, hyalocastite, tuff, unconsolidated U formation, and seoguipo formation and so on. Various conventional geophysical well loggings including radioactive logs (natural gamma log, dual neutron log, and gamma-gamma log), electrical log (or electromagnetic induction log), caliper log, fluid temperature/ conductivity log, and televiewer logs have been conducted to identify basalt sequences and permeable zone, and verify seawater intrusion in monitoring boreholes. The conductivity logs clearly show the fresh water-saline water boundaries, but we find it hard to identify the permeable zones because of the mixed groundwater within the boreholes. Temperature gradient logs are mostly related with lithologic boundaries and permeable zones intersected by boreholes of eastern coasts. The wide range of periodic electrical conductivity logging in the deeper depth of monitoring boreholes indicates the possibility of submarine groundwater discharge. However we did not clearly understand the origin of seawater intrusion in the eastern coast until now. So we analysis the electrical conductivity profiles, record of sea-level change and 40Ar/39Ar absolute ages of volcanic rock cores from twenty boreholes in east coast. From comparing absolute ages of volcanic rock cores and sea-level of their ages, we find that the almost ages of depth showing high salinity groundwater are about 100 Ka, and from 130Ka to about 180Ka. The former is after the interglacial period and the latter is illinoian. These results indicate that the abrupt raising of sea level after illinoian formed the regional coast, and the zone of present seawater intrusion also are above the depth of illinoin period. So we conclude that the origin of seawater intrusion in eastern coast is caused mainly by the sea-level change.

Empirical Evaluation of Advanced Electromagnetic Induction Systems - Factors Affecting Classification Effectiveness in Challenging Geologic Environments

DTIC Science & Technology

2016-10-01

Figure 2-2). The array structure is fabricated from PVC and Garolite fiberglass. The array is normally deployed on a set of wheels, resulting in a sensor...Low branches were cleared to 8 feet above ground to reduce obstruction of the RTS prism; large logs and fallen timber were not removed. CH2M also

Petrophysical analysis of geophysical logs of the National Drilling Company-U.S. Geological Survey ground-water research project for Abu Dhabi Emirate, United Arab Emirates

USGS Publications Warehouse

Jorgensen, Donald G.; Petricola, Mario

1994-01-01

A program of borehole-geophysical logging was implemented to supply geologic and geohydrologic information for a regional ground-water investigation of Abu Dhabi Emirate. Analysis of geophysical logs was essential to provide information on geohydrologic properties because drill cuttings were not always adequate to define lithologic boundaries. The standard suite of logs obtained at most project test holes consisted of caliper, spontaneous potential, gamma ray, dual induction, microresistivity, compensated neutron, compensated density, and compensated sonic. Ophiolitic detritus from the nearby Oman Mountains has unusual petrophysical properties that complicated the interpretation of geophysical logs. The density of coarse ophiolitic detritus is typically greater than 3.0 grams per cubic centimeter, porosity values are large, often exceeding 45 percent, and the clay fraction included unusual clays, such as lizardite. Neither the spontaneous-potential log nor the natural gamma-ray log were useable clay indicators. Because intrinsic permeability is a function of clay content, additional research in determining clay content was critical. A research program of geophysical logging was conducted to determine the petrophysical properties of the shallow subsurface formations. The logging included spectral-gamma and thermal-decay-time logs. These logs, along with the standard geophysical logs, were correlated to mineralogy and whole-rock chemistry as determined from sidewall cores. Thus, interpretation of lithology and fluids was accomplished. Permeability and specific yield were calculated from geophysical-log data and correlated to results from an aquifer test. On the basis of results from the research logging, a method of lithologic and water-resistivity interpretation was developed for the test holes at which the standard suite of logs were obtained. In addition, a computer program was developed to assist in the analysis of log data. Geohydrologic properties were estimated, including volume of clay matrix, volume of matrix other than clay, density of matrix other than clay, density of matrix, intrinsic permeability, specific yield, and specific storage. Geophysical logs were used to (1) determine lithology, (2) correlate lithologic and permeable zones, (3) calibrate seismic reprocessing, (4) calibrate transient-electromagnetic surveys, and (5) calibrate uphole-survey interpretations. Logs were used at the drill site to (1) determine permeability zones, (2) determine dissolved-solids content, which is a function of water resistivity, and (3) design wells accordingly. Data and properties derived from logs were used to determine transmissivity and specific yield of aquifer materials.

Sanitizer Efficacy against Murine Norovirus, a Surrogate for Human Norovirus, on Stainless Steel Surfaces when Using Three Application Methods

PubMed Central

Kotwal, Grishma; Harrison, Mark A.; Law, S. Edward; Harrison, Judy A.

2013-01-01

Human noroviruses are major etiologic agents of epidemic gastroenteritis. Outbreaks are often accompanied by contamination of environmental surfaces, but since these viruses cannot be routinely propagated in laboratory cultures, their response to surface disinfectants is predicted by using surrogates, such as murine norovirus 1 (MNV-1). This study compared the virucidal efficacies of various liquid treatments (three sanitizer liquids, 5% levulinic acid plus 2% SDS [LEV/SDS], 200 ppm chlorine, and an isopropanol-based quaternary ammonium compound [Alpet D2], and two control liquids, sterile tap water and sterile tap water plus 2% SDS) when delivered to MNV-1-inoculated stainless steel surfaces by conventional hydraulic or air-assisted, induction-charged (AAIC) electrostatic spraying or by wiping with impregnated towelettes. For the spray treatments, LEV/SDS proved effective when applied with hydraulic and AAIC electrostatic spraying, providing virus reductions of 2.71 and 1.66 log PFU/ml, respectively. Alpet D2 provided a 2.23-log PFU/ml reduction with hydraulic spraying, outperforming chlorine (1.16-log PFU/ml reduction). Chlorine and LEV/SDS were equally effective as wipes, reducing the viral load by 7.05 log PFU/ml. Controls reduced the viral load by <1 log with spraying applications and by >3 log PFU/ml with wiping. Results indicated that both sanitizer type and application methods should be carefully considered when choosing a surface disinfectant to best prevent and control environmental contamination by noroviruses. PMID:23263949

KSC-2013-2077

NASA Image and Video Library

2013-04-20

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronaut Curt Brown listens as he is being introduced for induction into the U.S. Astronaut Hall of Fame AHOF. Brown, a veteran of six spaceflights, began his career with NASA in 1987 as a pilot and has logged more than 1,383 hours in space. Brown’s missions aboard the space shuttle include STS-47, STS-66, STS-77, STS-85, STS-95 and STS-103. Shuttle astronauts Eileen Collins and Bonnie Dunbar also were inducted into the AHOF. This induction is the twelfth group of space shuttle astronauts named to the AHOF, and the first time two women are inducted at the same time. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. For more on the U.S. Astronaut Hall of Fame, go to http://www.kennedyspacecenter.com/astronaut-hall-of-fame.aspx For more on the Astronaut Scholarship Foundation, go to http://astronautscholarship.org/ Photo credit: NASA/ Kim Shiflett

KSC-2013-2076

NASA Image and Video Library

2013-04-20

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronaut Bonnie Dunbar speaks after being inducted into the U.S. Astronaut Hall of Fame AHOF. Dunbar received NASA’s Outstanding Leadership Award in 1993 and NASA’s Exceptional Service Medal in 1998 and 1991. During her career with NASA, she served as a mission specialist and a payload commander. Dunbar logged 1,208 hours in space, and her spaceflights include STS 61-A, STS-32, STS-50, STS-71 and STS-89. Shuttle astronauts Curt Brown and Eileen Collins also were inducted into the AHOF. This induction is the twelfth group of space shuttle astronauts named to the AHOF, and the first time two women are inducted at the same time. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. For more on the U.S. Astronaut Hall of Fame, go to http://www.kennedyspacecenter.com/astronaut-hall-of-fame.aspx For more on the Astronaut Scholarship Foundation, go to http://astronautscholarship.org/ Photo credit: NASA/ Kim Shiflett

Prophage Induction Is Enhanced and Required for Renal Disease and Lethality in an EHEC Mouse Model

PubMed Central

Reynolds, Jared L.; Alteri, Christopher J.; Skinner, Katherine G.; Friedman, Jonathan H.; Eaton, Kathryn A.; Friedman, David I.

2013-01-01

Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. And the bacterial subpopulation in which the 933W prophage is induced is the producer of Stx2. Using the germ-free mouse, we show the essential role 933W induction plays in the virulence of EDL933 infection. An EDL933 derivative with a single mutation in its 933W prophage, resulting specifically in that phage being uninducible, colonizes the intestines, but fails to cause any of the pathological changes seen with the parent strain. Hence, induction of the 933W prophage is the primary event leading to disease from EDL933 infection. We constructed a derivative of EDL933, SIVET, with a biosensor that specifically measures induction of the 933W prophage. Using this biosensor to measure 933W induction in germ-free mice, we found an increase three logs greater than was expected from in vitro results. Since the induced population produces and releases Stx2, this result indicates that an activity in the intestine increases Stx2 production. PMID:23555250

Downhole measurements in the AND-1B borehole, ANDRILL McMurdo Ice Shelf Project, Antarctica

USGS Publications Warehouse

Morin, R.; Williams, T.; Henrys, S.; Crosby, T.; Hansaraj, D.

2007-01-01

A comprehensive set of downhole measurements was collected in the AND-1B drillhole as part of the on-ice scientific programme defined for the McMurdo Ice Shelf (MIS) Project. Geophysical logs were recorded over two operation phases and consisted of calliper, temperature, fluid conductivity, induction resistivity, magnetic susceptibility, natural gamma activity, acoustic televiewer, borehole deviation, and dipmeter. In addition, two standard vertical seismic profiles (VSP) and one walk-away VSP were obtained. Radioactive logs (porosity and density) were not run because of unstable borehole conditions. Although the total depth of the hole is 1285 metres below seafloor (mbsf), the depth range for in situ measurements was limited by the length of the wireline (1018 mbsf) and by the nullification of some geophysical logs due to the presence of steel casing. A depth correction was derived to account for systematic discrepancies in depth between downhole measurements and cores; consequently, log responses can be directly compared to core properties. The resulting data are amenable to studies of cyclicity and climate, heat flux and fluid flow, and stricture and stress. When integrated with physical properties and fractures measured on the core, this information should play a significant role in addressing many of the scientific objectives of the ANDRILL programme.

Application of advanced geophysical logging methods in the characterization of a fractured-sedimentary bedrock aquifer, Ventura County, California

USGS Publications Warehouse

Williams, John H.; Lane, John W.; Singha, Kamini; Haeni, F. Peter

2002-01-01

An integrated suite of advanced geophysical logging methods was used to characterize the geology and hydrology of three boreholes completed in fractured-sedimentary bedrock in Ventura County, California. The geophysical methods included caliper, gamma, electromagnetic induction, borehole deviation, optical and acoustic televiewer, borehole radar, fluid resistivity, temperature, and electromagnetic flowmeter. The geophysical logging 1) provided insights useful for the overall geohydrologic characterization of the bedrock and 2) enhanced the value of information collected by other methods from the boreholes including core-sample analysis, multiple-level monitoring, and packer testing.The logged boreholes, which have open intervals of 100 to 200 feet, penetrate a sequence of interbedded sandstone and mudstone with bedding striking 220 to 250 degrees and dipping 15 to 40 degrees to the northwest. Fractures intersected by the boreholes include fractures parallel to bedding and fractures with variable strike that dip moderately to steeply. Two to three flow zones were detected in each borehole. The flow zones consist of bedding-parallel or steeply dipping fractures or a combination of bedding-parallel fractures and moderately to steeply dipping fractures. About 75 to more than 90 percent of the measured flow under pumped conditions was produced by only one of the flow zones in each borehole.

KSC-2013-2075

NASA Image and Video Library

2013-04-20

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronaut Bonnie Dunbar listens as she is being introduced for induction into the U.S. Astronaut Hall of Fame AHOF. Dunbar received NASA’s Outstanding Leadership Award in 1993 and NASA’s Exceptional Service Medal in 1998 and 1991. During her career with NASA, she served as a mission specialist and a payload commander. Dunbar logged 1,208 hours in space, and her spaceflights include STS 61-A, STS-32, STS-50, STS-71 and STS-89. Shuttle astronauts Curt Brown and Eileen Collins also were inducted into the AHOF. This induction is the twelfth group of space shuttle astronauts named to the AHOF, and the first time two women are inducted at the same time. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. For more on the U.S. Astronaut Hall of Fame, go to http://www.kennedyspacecenter.com/astronaut-hall-of-fame.aspx For more on the Astronaut Scholarship Foundation, go to http://astronautscholarship.org/ Photo credit: NASA/ Kim Shiflett

KSC-2013-2074

NASA Image and Video Library

2013-04-20

CAPE CANAVERAL, Fla. – At NASA’s Kennedy Space Center Visitor Complex in Florida, shuttle astronaut Bonnie Dunbar listens as she is being introduced for induction into the U.S. Astronaut Hall of Fame AHOF. Dunbar received NASA’s Outstanding Leadership Award in 1993 and NASA’s Exceptional Service Medal in 1998 and 1991. During her career with NASA, she served as a mission specialist and a payload commander. Dunbar logged 1,208 hours in space, and her spaceflights include STS 61-A, STS-32, STS-50, STS-71 and STS-89. Shuttle astronauts Curt Brown and Eileen Collins also were inducted into the AHOF. This induction is the twelfth group of space shuttle astronauts named to the AHOF, and the first time two women are inducted at the same time. The year’s inductees were selected by a committee of current Hall of Fame astronauts, former NASA officials, historians and journalists. The selection process is administered by the Astronaut Scholarship Foundation. For more on the U.S. Astronaut Hall of Fame, go to http://www.kennedyspacecenter.com/astronaut-hall-of-fame.aspx For more on the Astronaut Scholarship Foundation, go to http://astronautscholarship.org/ Photo credit: NASA/ Kim Shiflett

A field test of electromagnetic geophysical techniques for locating simulated in situ mining leach solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tweeton, D.R.; Hanson, J.C.; Friedel, M.J.

1994-01-01

The US Bureau of Mines, The University of Arizona, Sandia National Laboratories, and Zonge Engineering and Research Organization, Inc., conducted cooperative field tests of six electromagnetic (EM) geophysical methods to compare their effectiveness in locating a brine solution simulating in situ leach solution or a high-conductivity plume of contamination. The brine was approximately 160 m below the surface. The testsite was the University's San Xavier experimental mine near Tucson, AZ. Geophysical surveys using surface and surface-borehole, time-domain electromagnetic (TEM) induction; surface controlled-source audiofrequency magnetotellurics (CSAMT); surface-borehole, frequency-domain electromagnetic (FEM) induction; crosshole FEM; and surface magnetic field ellipticity were conducted beforemore » and during brine injection. The surface TEM data showed a broad decrease in resistivity. CSAMT measurements with the conventional orientation did not detect the brine, but measurements with another orientation indicated some decrease in resistivity. The surface-borehole and crosshole methods located a known fracture and other fracture zones inferred from borehole induction logs. Surface magnetic field ellipticity data showed a broad decrease in resistivity at depth following brine injection.« less

Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia

PubMed Central

O’Connor, David; Enshaei, Amir; Bartram, Jack; Hancock, Jeremy; Harrison, Christine J.; Hough, Rachael; Samarasinghe, Sujith; Schwab, Claire; Vora, Ajay; Wade, Rachel; Moppett, John; Moorman, Anthony V.; Goulden, Nick

2018-01-01

Purpose Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia. Current risk algorithms dichotomize MRD data and do not assimilate genetics when assigning MRD risk, which reduces predictive accuracy. The aim of our study was to exploit the full power of MRD by examining it as a continuous variable and to integrate it with genetics. Patients and Methods We used a population-based cohort of 3,113 patients who were treated in UKALL2003, with a median follow-up of 7 years. MRD was evaluated by polymerase chain reaction analysis of Ig/TCR gene rearrangements, and patients were assigned to a genetic subtype on the basis of immunophenotype, cytogenetics, and fluorescence in situ hybridization. To examine response kinetics at the end of induction, we log-transformed the absolute MRD value and examined its distribution across subgroups. Results MRD was log normally distributed at the end of induction. MRD distributions of patients with distinct genetic subtypes were different (P < .001). Patients with good-risk cytogenetics demonstrated the fastest disease clearance, whereas patients with high-risk genetics and T-cell acute lymphoblastic leukemia responded more slowly. The risk of relapse was correlated with MRD kinetics, and each log reduction in disease level reduced the risk by 20% (hazard ratio, 0.80; 95% CI, 0.77 to 0.83; P < .001). Although the risk of relapse was directly proportional to the MRD level within each genetic risk group, absolute relapse rate that was associated with a specific MRD value or category varied significantly by genetic subtype. Integration of genetic subtype–specific MRD values allowed more refined risk group stratification. Conclusion A single threshold for assigning patients to an MRD risk group does not reflect the response kinetics of the different genetic subtypes. Future risk algorithms should integrate genetics with MRD to accurately identify patients with the lowest and highest risk of relapse. PMID:29131699

Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Jian; Chung, K.Fan

1997-09-01

The effect of prior ozone (O{sub 3}) exposure on airway hyperresponsiveness and inflammation induced by trimellitic anhydride (TMA) has been investigated in TMA-sensitized guinea pigs. Airway responsiveness was measured as the concentration of acetylcholine needed to increase baseline lung resistance (RL) by 300% (PC300). Ozone (3 ppm, for 3 h) caused an increase in-log PC300 at 1 h after exposure, with return of -log PC300 to control levels at 8 h. Ozone also increased baseline RL at 8 h. TMA challenge increase -log PC300 in TMA-sensitized guinea pigs at 8 h after challenge from 3.85 {+-} 0.09 to 4.11 {+-}more » 0.09. Ozone exposure prior to TMA challenge prevented the induction of airway hyperresponsiveness with a mean -log PC300 of 3.51 {+-} 0.20, which was not different from that of control TMA-Sensitized group. Baseline RL was significantly higher in ozone-pretreated animals after TMA challenge when compared to those of either control or challenged with TMA alone. Ozone had no effect on TMA challenge-induced BAL eosinophilia and neutrophilia. We conclude that a single exposure to ozone inhibits the increase in airway responsiveness, but increases the bronchoconstrictor response induced by TMA in TMA-Sensitized guinea pigs; however, the inflammatory airway response to TMA is unchanged by preexposure to ozone. 29 refs., 2 figs., 1 tab.« less

Digital signal processing and interpretation of full waveform sonic log for well BP-3-USGS, Great Sand Dunes National Park and Preserve, Alamosa County, Colorado

USGS Publications Warehouse

Burke, Lauri

2011-01-01

Along the Great Sand Dunes National Park and Preserve boundary (fig. 1), 10 monitoring wells were drilled by the National Park Service in order to monitor water flow in an unconfined aquifer spanning the park boundary. Adjacent to the National Park Service monitoring well named Boundary Piezometer Well No. 3, or BP-3, the U.S. Geological Survey (USGS) drilled the BP-3-USGS well. This well was drilled from September 14 through 17, 2009, to a total depth of 99.4 meters (m) in order to acquire additional subsurface information. The BP-3-USGS well is located at lat 37 degrees 43'18.06' and long -105 degrees 43'39.30' at a surface elevation of 2,301 m. Approximately 23 m of core was recovered beginning at a depth of 18 m. Drill cuttings were also recovered. The wireline geophysical logs acquired in the well include natural gamma ray, borehole caliper, temperature, full waveform sonic, density, neutron, resistivity, and induction logs. The BP-3-USGS well is now plugged and abandoned. This report details the full waveform digital signal processing methodology and the formation compressional-wave velocities determined for the BP-3-USGS well. These velocity results are compared to several velocities that are commonly encountered in the subsurface. The density log is also discussed in context of these formation velocities.

Pretreatment of low dose radiation reduces radiation-induced apoptosis in mouse lymphoma (EL4) cells.

PubMed

Kim, J H; Hyun, S J; Yoon, M Y; Ji, Y H; Cho, C K; Yoo, S Y

1997-06-01

Induction of an adaptive response to ionizing radiation in mouse lymphoma (EL4) cells was studied by using cell survival fraction and apoptotic nucleosomal DNA fragmentation as biological end points. Cells in early log phase were pre-exposed to low dose of gamma-rays (0.01 Gy) 4 or 20 hrs prior to high dose gamma-ray (4, 8 and 12 Gy for cell survival fraction analysis; 8 Gy for DNA fragmentation analysis) irradiation. Then cell survival fractions and the extent of DNA fragmentation were measured. Significant adaptive response, increase in cell survival fraction and decrease in the extent of DNA fragmentation were induced when low and high dose gamma-ray irradiation time interval was 4 hr. Addition of protein or RNA synthesis inhibitor, cycloheximide or 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRFB), respectively during adaptation period, the period from low dose gamma-ray irradiation to high dose gamma-ray irradiation, was able to inhibit the induction of adaptive response, which is the reduction of the extent DNA fragmentation in irradiated EL4 cells. These data suggest that the induction of adaptive response to ionizing radiation in EL4 cells required both protein and RNA synthesis.

Fishing tool retrieves MWD nuclear source from deep well

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

A new wire line tool has successfully retrieved the nuclear sources and formation data from a measurement-while-drilling (MWD) tool stuck in a deep, highly deviated well in the Gulf of Mexico. On Nov. 8, 1993, Schlumberger Wireline and Testing and Anadrill ran a logging-while-drilling inductive coupling (LINC) tool on conventional wire line to fish the gamma ray and neutron sources from a compensated density neutron (CDN) tool stuck in a well at 19,855 ft with an inclination greater than 80[degree]. The paper briefly describes the operation and equipment.

Simulation Modeling of the C-5 Galaxy High Velocity Regionalized Isochronal (HVRISO) Inspection Concept

DTIC Science & Technology

2009-03-01

flu en ce Lo g Q ue ue 4 8 X 2 0 100 200 300 400 500 600 700 Row s Breusch - Pagan Response Residual Log Queue 48 X Squared Whole Model Actual...aircraft cannot be immediately inducted into the servicing inspection dock. This study uses discrete-event simulation techniques to test the...for a 10 percent boost in reliability (Hebert, 2007). With 2 C-5Bs and 1 C-5A retrofitted with RERP for test and evaluation purposes, Air Force

Saline aquifer mapping project in the southeastern United States

USGS Publications Warehouse

Williams, Lester J.; Spechler, Rick M.

2011-01-01

In 2009, the U.S. Geological Survey initiated a study of saline aquifers in the southeastern United States to evaluate the potential use of brackish or saline water from the deeper portions of the Floridan aquifer system and the underlying Coastal Plain aquifer system (Fig. 1). The objective of this study is to improve the overall understanding of the available saline water resources for potential future development. Specific tasks are to (1) develop a digital georeferenced database of borehole geophysical data to enable analysis and characterization of saline aquifers (see locations in Fig. 1), (2) identify and map the regional extent of saline aquifer systems and describe the thickness and character of hydrologic units that compose these systems, and (3) delineate salinity variations at key well sites and along section lines to provide a regional depiction of the freshwater-saltwater interfaces. Electrical resistivity and induction logs, coupled with a variety of different porosity logs (sonic, density, and neutron), are the primary types of borehole geophysical logs being used to estimate the water quality in brackish and saline formations. The results from the geophysical log calculations are being compared to available water-quality data obtained from water wells and from drill-stem water samples collected in test wells. Overall, the saline aquifer mapping project is helping to improve the understanding of saline water resources in the area. These aquifers may be sources of large quantities of water that could be treated by using reverse osmosis or similar technologies, or they could be used for aquifer storage and recovery systems.

Real-time use of the iPad by third-year medical students for clinical decision support and learning: a mixed methods study.

PubMed

Nuss, Michelle A; Hill, Janette R; Cervero, Ronald M; Gaines, Julie K; Middendorf, Bruce F

2014-01-01

Despite widespread use of mobile technology in medical education, medical students' use of mobile technology for clinical decision support and learning is not well understood. Three key questions were explored in this extensive mixed methods study: 1) how medical students used mobile technology in the care of patients, 2) the mobile applications (apps) used and 3) how expertise and time spent changed overtime. This year-long (July 2012-June 2013) mixed methods study explored the use of the iPad, using four data collection instruments: 1) beginning and end-of-year questionnaires, 2) iPad usage logs, 3) weekly rounding observations, and 4) weekly medical student interviews. Descriptive statistics were generated for the questionnaires and apps reported in the usage logs. The iPad usage logs, observation logs, and weekly interviews were analyzed via inductive thematic analysis. Students predominantly used mobile technology to obtain real-time patient data via the electronic health record (EHR), to access medical knowledge resources for learning, and to inform patient care. The top four apps used were Epocrates(®), PDF Expert(®), VisualDx(®), and Micromedex(®). The majority of students indicated that their use (71%) and expertise (75%) using mobile technology grew overtime. This mixed methods study provides substantial evidence that medical students used mobile technology for clinical decision support and learning. Integrating its use into the medical student's daily workflow was essential for achieving these outcomes. Developing expertise in using mobile technology and various apps was critical for effective and efficient support of real-time clinical decisions.

Characterization of fractures and flow zones in a contaminated crystalline-rock aquifer in the Tylerville section of Haddam, Connecticut

USGS Publications Warehouse

Johnson, Carole D.; Kiel, Kristal F.; Joesten, Peter K.; Pappas, Katherine L.

2016-10-04

The U.S. Geological Survey, in cooperation with the Connecticut Department of Energy and Environmental Protection, investigated the characteristics of the bedrock aquifer in the Tylerville section of Haddam, Connecticut, from June to August 2014. As part of this investigation, geophysical logs were collected from six water-supply wells and were analyzed to (1) identify well construction, (2) determine the rock type and orientation of the foliation and layering of the rock, (3) characterize the depth and orientation of fractures, (4) evaluate fluid properties of the water in the well, and (5) determine the relative transmissivity and head of discrete fractures or fracture zones. The logs included the following: caliper, electromagnetic induction, gamma, acoustic and (or) optical televiewer, heat-pulse flowmeter under ambient and pumped conditions, hydraulic head data, fluid electrical conductivity and temperature under postpumping conditions, and borehole-radar reflection collected in single-hole mode. In a seventh borehole, a former water-supply well, only caliper, fluid electrical conductivty, and temperature logs were collected, because of a constriction in the borehole.This report includes a description of the methods used to collect and process the borehole geophysical data, the description of the data collected in each of the wells, and a comparison of the results collected in all of the wells. The data are presented in plots of the borehole geophysical logs, tables, and figures. Collectively these data provide valuable characterizations that can be used to improve or inform site conceptual models of groundwater flow in the study area.

Near Surface Investigation of Agricultural Soils using a Multi-Frequency Electromagnetic Sensor

NASA Astrophysics Data System (ADS)

Sadatcharam, K.; Unc, A.; Krishnapillai, M.; Cheema, M.; Galagedara, L.

2017-12-01

Electromagnetic induction (EMI) sensors have been used as precision agricultural tools over decades. They are being used to measure spatiotemporal variability of soil properties and soil stratification in the sense of apparent electrical conductivity (ECa). We mapped the ECa variability by horizontal coplanar (HCP) and by vertical coplanar (VCP) orientation of a multi-frequency EMI sensor and identified its interrelation with physical properties of soil. A broadband, multi-frequency handheld EMI sensor (GEM-2) was used on a loamy sand soil cultivated with silage-corn in western Newfoundland, Canada. Log and line spaced, three frequency ranges (weak, low, and high), based on the factory calibration were tested using HCP and VCP orientation to produce spatiotemporal data of ECa. In parallel, we acquired data on soil moisture content, texture and bulk density. We then assessed the statistical significance of the relationship between ECa and soil physical properties. The test site had three areas of distinct soil properties corresponding to the elevation, in particular. The same spatial variability was also identified by ECa mapping at different frequencies and the two modes of coil orientations. Data analysis suggested that the high range frequency (38 kHz (log-spaced) and 49 kHz (line-spaced)) for both HCP and VCP orientations produced accurate ECa maps, better than the weak and low range frequencies tested. Furthermore, results revealed that the combined effects of soil texture, moisture content and bulk density affect ECameasurements as obtained by both frequencies and two coil orientations. Keywords: Apparent electrical conductivity, Electromagnetic induction, Horizontal coplanar, Soil properties, Vertical coplanar

KSC-06pd0790

NASA Image and Video Library

2006-05-06

KENNEDY SPACE CENTER, FLA. - Brewster H. Shaw Jr. (right) accepts congratulations from Al Worden, U.S. Astronaut Hall of Fame member and chairman of the Astronaut Scholarship Foundation. The occasion is the 2006 induction ceremony for the U.S. Astronaut Hall of Fame, held in the Apollo/Saturn V Center. The inductees for 2006 are former NASA astronauts Shaw, Henry "Hank" Hartsfield Jr., and Charles F. Bolden Jr. Shaw flew on three space shuttle missions including STS-9, STS-61B, STS-28, logging 533 hours in space. The U.S. Astronaut Hall of Fame now includes 63 space explorers. Photo credit: NASA/Kim Shiflett

2016 U.S. Astronaut Hall of Fame Induction

NASA Image and Video Library

2016-04-14

The U.S. Astronaut Hall of Fame welcomed astronaut inductees Brian Duffy and Scott Parazynski to its ranks during a May 14 ceremony at the Kennedy Space Center Visitor Complex, in Florida. Parazynski, who retired from NASA in 2009, flew on five spaceflights and performed seven spacewalks during his career. Duffy, retired from the Air Force and NASA in 2001. He logged more than forty total days in space during his four spaceflights. The pair join an elite group of well-known space explorers, including Alan Shepard, John Glenn, John Young, Neil Armstrong and Sally Ride.

KSC-06pd0789

NASA Image and Video Library

2006-05-06

KENNEDY SPACE CENTER, FLA. - Henry "Hank" Hartsfield Jr. (right) accepts congratulations from Al Worden, U.S. Astronaut Hall of Fame member and chairman of the Astronaut Scholarship Foundation. The occasion is the 2006 induction ceremony for the U.S. Astronaut Hall of Fame, held in the Apollo/Saturn V Center. The inductees for 2006 are former NASA astronauts Hartsfield, Brewster H. Shaw Jr. and Charles F. Bolden Jr. Hartsfield flew on three space shuttle missions including STS-4, STS-41D and STS-61A, logging 482 hours in space. The U.S. Astronaut Hall of Fame now includes 63 space explorers. Photo credit: NASA/Kim Shiflett

High dose melphalan in the treatment of advanced neuroblastoma: results of a randomised trial (ENSG-1) by the European Neuroblastoma Study Group.

PubMed

Pritchard, Jon; Cotterill, Simon J; Germond, Shirley M; Imeson, John; de Kraker, Jan; Jones, David R

2005-04-01

High dose myeloablative chemotherapy ("megatherapy"), with haematopoietic stem cell support, is now widely used to consolidate response to induction chemotherapy in patients with advanced neuroblastoma. In this study (European Neuroblastoma Study Group, ENSG1), the value of melphalan myeloablative "megatherapy" was evaluated in a randomised, multi-centre trial. Between 1982 and 1985, 167 children with stages IV and III neuroblastoma (123 stage IV > 1 year old at diagnosis and 44 stage III and stage IV from 6 to 12 months old at diagnosis) were treated with oncovin, cisplatin, epipodophyllotoxin, and cyclophosphamide (OPEC) induction chemotherapy every 3 weeks. After surgical excision of primary tumour, the 90 patients (69% of the total) who achieved complete response (CR) or good partial response (GPR) were eligible for randomisation either to high dose melphalan (180 mg per square meter) with autologous bone marrow support or to no further treatment. Sixty-five (72%) of eligible children were actually randomised and 21 of these patients were surviving at time of this analysis, with median follow-up from randomisation of 14.3 years. Five year event-free survival (EFS) was 38% (95% confidence interval (CI) 21-54%) in the melphalan-treated group and 27% (95% CI 12-42%) in the "no-melphalan" group. This difference was not statistically significant (P = 0.08, log rank test) but for the 48 randomised stage IV patients aged >1 year at diagnosis outcome was significantly better in the melphalan-treated group-5 year EFS 33% versus 17% (P = 0.01, log rank test). In this trial, high dose melphalan improved the length of EFS and overall survival of children with stage IV neuroblastoma >1 year of age who achieved CR or GPR after OPEC induction therapy and surgery. Multi-agent myeloablative regimens are now widely used as consolidation therapy for children with stage IV disease and in those with other disease stages when the MYCN gene copy number in tumour cells is amplified. Because they are more toxic, complex, and costly these combination megatherapy regimens should be compared with single agent melphalan in randomised clinical trials.

Using open hole and cased-hole resistivity logs to monitor gas hydrate dissociation during a thermal test in the mallik 5L-38 research well, Mackenzie Delta, Canada

USGS Publications Warehouse

Anderson, B.I.; Collett, T.S.; Lewis, R.E.; Dubourg, I.

2008-01-01

Gas hydrates, which are naturally occurring ice-like combinations of gas and water, have the potential to provide vast amounts of natural gas from the world's oceans and polar regions. However, producing gas economically from hydrates entails major technical challenges. Proposed recovery methods such as dissociating or melting gas hydrates by heating or depressurization are currently being tested. One such test was conducted in northern Canada by the partners in the Mallik 2002 Gas Hydrate Production Research Well Program. This paper describes how resistivity logs were used to determine the size of the annular region of gas hydrate dissociation that occurred around the wellbore during the thermal test in the Mallik 5L-38 well. An open-hole logging suite, run prior to the thermal test, included array induction, array laterolog, nuclear magnetic resonance and 1.1-GHz electromagnetic propagation logs. The reservoir saturation tool was run both before and after the thermal test to monitor formation changes. A cased-hole formation resistivity log was run after the test.Baseline resistivity values in each formation layer (Rt) were established from the deep laterolog data. The resistivity in the region of gas hydrate dissociation near the wellbore (Rxo) was determined from electromagnetic propagation and reservoir saturation tool measurements. The radius of hydrate dissociation as a function of depth was then determined by means of iterative forward modeling of cased-hole formation resistivity tool response. The solution was obtained by varying the modeled dissociation radius until the modeled log overlaid the field log. Pretest gas hydrate production computer simulations had predicted that dissociation would take place at a uniform radius over the 13-ft test interval. However, the post-test resistivity modeling showed that this was not the case. The resistivity-derived dissociation radius was greatest near the outlet of the pipe that circulated hot water in the wellbore, where the highest temperatures were recorded. The radius was smallest near the center of the test interval, where a conglomerate section with low values of porosity and permeability inhibited dissociation. The free gas volume calculated from the resistivity-derived dissociation radii yielded a value within 20 per cent of surface gauge measurements. These results show that the inversion of resistivity measurements holds promise for use in future gas hydrate monitoring. ?? 2008 Society of Petrophysicists and Well Log Analysts. All rights reserved.

Use of advanced borehole geophysical techniques to delineate fractured-rock ground-water flow and fractures along water-tunnel facilities in northern Queens County, New York

USGS Publications Warehouse

Stumm, Frederick; Chu, Anthony; Lange, Andrew D.; Paillet, Frederick L.; Williams, John H.; Lane, John W.

2001-01-01

Advanced borehole geophysical methods were used to assess the geohydrology of crystalline bedrock along the course of a new water tunnel for New York City. The logging methods include natural gamma, spontaneous potential, single-point resistance, mechanical and acoustic caliper, focused electromagnetic induction, electromagnetic resistivity, magnetic susceptibility, borehole-fluid temperature and conductance, differential temperature, heat-pulse flowmeter, acoustic televiewer, borehole deviation, optical televiewer, and borehole radar. Integrated interpretation of the geophysical logs from an 825-foot borehole (1) provided information on the extent, orientation, and structure (foliation and fractures) within the entire borehole, including intensely fractured intervals from which core recovery may be poor; (2) delineated transmissive fracture zones intersected by the borehole and provided estimates of their transmissivity and hydraulic head; and (3) enabled mapping of the location and orientation of structures at distances as much as 100 ft from the borehole.Analyses of the borehole-wall image and the geophysical logs from the borehole on Crescent Street, in northern Queens County, are presented here to illustrate the application of the methods. The borehole penetrates gneiss and other crystalline bedrock that has predominantly southeastward dipping foliation and nearly horizontal and southeastward-dipping fractures. The heat-pulse flowmeter logs obtained under pumping and nonpumping conditions, together with the other geophysical logs, indicate five transmissive fracture zones. More than 90 percent of the open-hole transmissivity is associated with a fracture zone 272 feet BLS (below land surface). A transmissive zone at 787 feet BLS that consists of nearly parallel fractures lies within the projected tunnel path; here the hydraulic head is 12 to 15 feet lower than that of transmissive zones above the 315-foot depth. The 60-megahertz directional borehole radar logs indicate the location and orientation of two closely spaced radar reflectors that would intersect the projection of the borehole below its drilled depth.Subsequent excavation of the tunnel past the borehole allowed comparison of the log analysis with conditions observed in the tunnel. The tunnel was found to intersect gneiss with southeastward dipping foliation; many nearly horizontal fractures; and a southeastward dipping fracture zone whose location, character, and orientation was consistent with that of the mapped radar reflectors. The fracture zone produced inflow to the tunnel at a rate of 50 to 100 gallons per minute. All conditions indicated by the logging methods were consistent with those observed within the tunnel.

Dual excitation acoustic paramagnetic logging tool

DOEpatents

Vail, III, William B.

1989-01-01

New methods and apparatus are disclosed which allow measurement of the presence of oil and water in gelogical formations using a new physical effect called the Acoustic Paramagnetic Logging Effect (APLE). The presence of petroleum in formation causes a slight increase in the earth's magnetic field in the vicinity of the reservoir. This is the phenomena of paramagnetism. Application of an acoustic source to a geological formation at the Larmor frequency of the nucleous present causes the paramagnetism of the formation to disappear. This results in a decrease in the earth's magnetic field in the vicinity of the oil bearing formation. Repetitively frequency sweeping the acoustic source through the Larmor frequency of the nucleons present (approx. 2 kHz) causes an amplitude modulation of the earth's magnetic field which is a consequence of the APLE. The amplitude modulation of the earth's magnetic field is measured with an induction coil gradiometer and provides a direct measure of the amount of oil and water in the excitation zone of the formation. The phase of the signal is used to infer the longitudinal relaxation times of the fluids present, which results in the ability in general to separate oil and water and to measure the viscosity of the oil present. Such measurements may be preformed in open boreholes and in cased well bores. The Dual Excitation Acoustic Paramagnetic Logging Tool employing two acoustic sources is also described.

Geologic, hydrologic, and water-quality data from multiple-well monitoring sites in the Central and West Coast basins, Los Angeles County, California, 1995-2000

USGS Publications Warehouse

Land, Michael; Everett, R.R.; Crawford, S.M.

2002-01-01

In 1995, the U.S. Geological Survey (USGS), in cooperation with the HYPERLINK 'http://wrd.org' Water Replenishment District of Southern California (WRDSC), began a study to examine ground-water resources in the Central and West Coast Basins in Los Angeles County, California. The study characterizes the geohydrology and geochemistry of the regional ground-water flow system and provides extensive data for evaluating ground-water management issues. This report is a compilation of geologic, hydrologic, and water-quality data collected from 24 recently constructed multiple-well monitoring sites for the period 1995?2000. Descriptions of the collected drill cuttings were compiled into lithologic logs, which are summarized along with geophysical logs?including gamma-ray, spontaneous potential, resistivity, electromagnetic induction, and temperature tool logs?for each monitoring site. At selected sites, cores were analyzed for magnetic orientation, physical and thermal properties, and mineralogy. Field and laboratory estimates of hydraulic conductivity are presented for most multiple-well monitoring sites. Periodic water-level measurements are also reported. Water-quality information for major ions, nutrients, trace elements, deuterium and oxygen-18, and tritium is presented for the multiple-well monitoring locations, and for selected existing production and observation wells. In addition, boron-11, carbon-13, carbon-14, sulfur-34, and strontium-87/86 data are presented for selected wells.

Persistence of Infectious Shiga Toxin-Encoding Bacteriophages after Disinfection Treatments

PubMed Central

Allué-Guardia, Anna; Martínez-Castillo, Alexandre

2014-01-01

In Shiga toxin-producing Escherichia coli (STEC), induction of Shiga toxin-encoding bacteriophages (Stx phages) causes the release of free phages that can later be found in the environment. The ability of Stx phages to survive different inactivation conditions determines their prevalence in the environment, the risk of stx transduction, and the generation of new STEC strains. We evaluated the infectivity and genomes of two Stx phages (Φ534 and Φ557) under different conditions. Infectious Stx phages were stable at 4, 22, and 37°C and at pH 7 and 9 after 1 month of storage but were completely inactivated at pH 3. Infective Stx phages decreased moderately when treated with UV (2.2-log10 reduction for an estimated UV dose of 178.2 mJ/cm2) or after treatment at 60 and 68°C for 60 min (2.2- and 2.5-log10 reductions, respectively) and were highly inactivated (3 log10) by 10 ppm of chlorine in 1 min. Assays in a mesocosm showed lower inactivation of all microorganisms in winter than in summer. The number of Stx phage genomes did not decrease significantly in most cases, and STEC inactivation was higher than phage inactivation under all conditions. Moreover, Stx phages retained the ability to lysogenize E. coli after some of the treatments. PMID:24463973

Dual excitation acoustic paramagnetic logging tool

DOEpatents

Vail, W.B. III.

1989-02-14

New methods and apparatus are disclosed which allow measurement of the presence of oil and water in geological formations using a new physical effect called the Acoustic Paramagnetic Logging Effect (APLE). The presence of petroleum in formation causes a slight increase in the earth's magnetic field in the vicinity of the reservoir. This is the phenomena of paramagnetism. Application of an acoustic source to a geological formation at the Larmor frequency of the nucleons present causes the paramagnetism of the formation to disappear. This results in a decrease in the earth's magnetic field in the vicinity of the oil bearing formation. Repetitively frequency sweeping the acoustic source through the Larmor frequency of the nucleons present (approx. 2 kHz) causes an amplitude modulation of the earth's magnetic field which is a consequence of the APLE. The amplitude modulation of the earth's magnetic field is measured with an induction coil gradiometer and provides a direct measure of the amount of oil and water in the excitation zone of the formation. The phase of the signal is used to infer the longitudinal relaxation times of the fluids present, which results in the ability in general to separate oil and water and to measure the viscosity of the oil present. Such measurements may be performed in open boreholes and in cased well bores. The Dual Excitation Acoustic Paramagnetic Logging Tool employing two acoustic sources is also described. 6 figs.

Induction dosing of peginterferon alfa-2a (40 KD) and/or high-dose ribavirin in genotype 1 CHC patients with difficult-to-treat characteristics: pharmacokinetic and viral kinetic (PK/VK) assessment from PROGRESS.

PubMed

Morcos, Peter N; Leong, Ruby; Thommes, James A; DePamphilis, Jean; Grippo, Joseph F; Brennan, Barbara J

2015-01-01

PROGRESS randomized chronic hepatitis C genotype 1 patients with a baseline viral load ≥400,000 IU/mL weighing ≥85 kg to regimens of 180 μg/week for 48 weeks or 360 μg/week for 12 weeks followed by 180 μg/week for 36 weeks peginterferon alfa-2a plus ribavirin. This analysis explored pharmacokinetics and early viral kinetics (VK) and evaluates differences between groups. Blood samples for pharmacokinetic and VK analyses were collected from 51 patients enrolled in the PROGRESS study. Mean peginterferon alfa-2a trough concentration at week 12 was 11.7±4.3 ng/mL for 180 μg and 23.4±11.3 ng/mL for 360 μg. Early VK profiles suggested a trend towards an enhanced viral decline in the 360 μg groups with a mean decrease in HCV RNA at 48 hours post first dose of 1.04 log10 (IU/mL) compared with 0.76 log10 (IU/mL) in the 180 μg groups. Mean beta slope increased with dose, ranging from 0.38±0.26 log10 IU/week at 180 μg to 0.52±0.32 log10 IU/week at 360 μg. Early viral de clines may be enhanced with the 360 μg dose. These data may suggest the utility of high-dose peginterfer on alfa-2a plus direct-acting antivirals (DAA) in select difficult-to-treat populations.

Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects.

PubMed

Barbosa, Fernando; Corrêa Rodrigues, Maria Heloísa; Buzalaf, Maria R; Krug, Francisco J; Gerlach, Raquel F; Tanus-Santos, José Eduardo

2006-10-01

We conducted a study to evaluate the use of parotid salivary lead (Pb-saliva) levels as a surrogate of the blood lead (Pb-B) or plasma lead levels (Pb-P) to diagnose lead exposure. The relationship between these biomarkers was assessed in a lead exposed population. Pb-saliva and Pb-P were determined by inductively coupled plasma mass spectrometry, while in whole blood lead was determined by graphite furnace atomic absorption spectrometry. We studied 88 adults (31 men and 57 women) from 18 to 60 years old. Pb-saliva levels varied from 0.05 to 4.4 microg/l, with a mean of 0.85 microg/l. Blood lead levels varied from 32.0 to 428.0 microg/l in men (mean 112.3 microg/l) and from 25.0 to 263.0 microg/l (mean 63.5 microg/l) in women. Corresponding Pb-Ps were 0.02-2.50 microg/l (mean 0.77 microg/l) and 0.03-1.6 microg/l (mean 0.42 microg/l) in men and women, respectively. A weak correlation was found between Log Pb-saliva and Log Pb-B (r=0.277, P<0.008), and between Log Pb-saliva and Log Pb-P (r=0.280, P=0.006). The Pb-saliva/Pb-P ratio ranged from 0.20 to 18.0. Age or gender does not affect Pb-saliva levels or Pb-saliva/Pb-P ratio. Taken together, these results suggest that salivary lead may not be used as a biomarker to diagnose lead exposure nor as a surrogate of plasma lead levels at least for low to moderately lead exposed population.

Real-time use of the iPad by third-year medical students for clinical decision support and learning: a mixed methods study

PubMed Central

Nuss, Michelle A.; Hill, Janette R.; Cervero, Ronald M.; Gaines, Julie K.; Middendorf, Bruce F.

2014-01-01

Purpose Despite widespread use of mobile technology in medical education, medical students’ use of mobile technology for clinical decision support and learning is not well understood. Three key questions were explored in this extensive mixed methods study: 1) how medical students used mobile technology in the care of patients, 2) the mobile applications (apps) used and 3) how expertise and time spent changed overtime. Methods This year-long (July 2012–June 2013) mixed methods study explored the use of the iPad, using four data collection instruments: 1) beginning and end-of-year questionnaires, 2) iPad usage logs, 3) weekly rounding observations, and 4) weekly medical student interviews. Descriptive statistics were generated for the questionnaires and apps reported in the usage logs. The iPad usage logs, observation logs, and weekly interviews were analyzed via inductive thematic analysis. Results Students predominantly used mobile technology to obtain real-time patient data via the electronic health record (EHR), to access medical knowledge resources for learning, and to inform patient care. The top four apps used were Epocrates®, PDF Expert®, VisualDx®, and Micromedex®. The majority of students indicated that their use (71%) and expertise (75%) using mobile technology grew overtime. Conclusions This mixed methods study provides substantial evidence that medical students used mobile technology for clinical decision support and learning. Integrating its use into the medical student's daily workflow was essential for achieving these outcomes. Developing expertise in using mobile technology and various apps was critical for effective and efficient support of real-time clinical decisions. PMID:25317266

Factors Limiting SOS Expression in Log-Phase Cells of Escherichia coli

PubMed Central

Massoni, Shawn C.; Leeson, Michael C.; Long, Jarukit Edward; Gemme, Kristin; Mui, Alice

2012-01-01

In Escherichia coli, RecA–single-stranded DNA (RecA-ssDNA) filaments catalyze DNA repair, recombination, and induction of the SOS response. It has been shown that, while many (15 to 25%) log-phase cells have RecA filaments, few (about 1%) are induced for SOS. It is hypothesized that RecA's ability to induce SOS expression in log-phase cells is repressed because of the potentially detrimental effects of SOS mutagenesis. To test this, mutations were sought to produce a population where the number of cells with SOS expression more closely equaled the number of RecA filaments. Here, it is shown that deleting radA (important for resolution of recombination structures) and increasing recA transcription 2- to 3-fold with a recAo1403 operator mutation act independently to minimally satisfy this condition. This allows 24% of mutant cells to have elevated levels of SOS expression, a percentage similar to that of cells with RecA-green fluorescent protein (RecA-GFP) foci. In an xthA (exonuclease III gene) mutant where there are 3-fold more RecA loading events, recX (a destabilizer of RecA filaments) must be additionally deleted to achieve a population of cells where the percentage having elevated SOS expression (91%) nearly equals the percentage with at least one RecA-GFP focus (83%). It is proposed that, in the xthA mutant, there are three independent mechanisms that repress SOS expression in log-phase cells. These are the rapid processing of RecA filaments by RadA, maintaining the concentration of RecA below a critical level, and the destabilizing of RecA filaments by RecX. Only the first two mechanisms operate independently in a wild-type cell. PMID:22843848

Factors limiting SOS expression in log-phase cells of Escherichia coli.

PubMed

Massoni, Shawn C; Leeson, Michael C; Long, Jarukit Edward; Gemme, Kristin; Mui, Alice; Sandler, Steven J

2012-10-01

In Escherichia coli, RecA-single-stranded DNA (RecA-ssDNA) filaments catalyze DNA repair, recombination, and induction of the SOS response. It has been shown that, while many (15 to 25%) log-phase cells have RecA filaments, few (about 1%) are induced for SOS. It is hypothesized that RecA's ability to induce SOS expression in log-phase cells is repressed because of the potentially detrimental effects of SOS mutagenesis. To test this, mutations were sought to produce a population where the number of cells with SOS expression more closely equaled the number of RecA filaments. Here, it is shown that deleting radA (important for resolution of recombination structures) and increasing recA transcription 2- to 3-fold with a recAo1403 operator mutation act independently to minimally satisfy this condition. This allows 24% of mutant cells to have elevated levels of SOS expression, a percentage similar to that of cells with RecA-green fluorescent protein (RecA-GFP) foci. In an xthA (exonuclease III gene) mutant where there are 3-fold more RecA loading events, recX (a destabilizer of RecA filaments) must be additionally deleted to achieve a population of cells where the percentage having elevated SOS expression (91%) nearly equals the percentage with at least one RecA-GFP focus (83%). It is proposed that, in the xthA mutant, there are three independent mechanisms that repress SOS expression in log-phase cells. These are the rapid processing of RecA filaments by RadA, maintaining the concentration of RecA below a critical level, and the destabilizing of RecA filaments by RecX. Only the first two mechanisms operate independently in a wild-type cell.

Induction of Shiga Toxin-Encoding Prophage by Abiotic Environmental Stress in Food.

PubMed

Fang, Yuan; Mercer, Ryan G; McMullen, Lynn M; Gänzle, Michael G

2017-10-01

The prophage-encoded Shiga toxin is a major virulence factor in Stx-producing Escherichia coli (STEC). Toxin production and phage production are linked and occur after induction of the RecA-dependent SOS response. However, food-related stress and Stx-prophage induction have not been studied at the single-cell level. This study investigated the effects of abiotic environmental stress on stx expression by single-cell quantification of gene expression in STEC O104:H4 Δ stx2 :: gfp :: amp r In addition, the effect of stress on production of phage particles was determined. The lethality of stressors, including heat, HCl, lactic acid, hydrogen peroxide, and high hydrostatic pressure, was selected to reduce cell counts by 1 to 2 log CFU/ml. The integrity of the bacterial membrane after exposure to stress was measured by propidium iodide (PI). The fluorescent signals of green fluorescent protein (GFP) and PI were quantified by flow cytometry. The mechanism of prophage induction by stress was evaluated by relative gene expression of recA and cell morphology. Acid (pH < 3.5) and H 2 O 2 (2.5 mM) induced the expression of stx 2 in about 18% and 3% of the population, respectively. The mechanism of prophage induction by acid differs from that of induction by H 2 O 2 H 2 O 2 induction but not acid induction corresponded to production of infectious phage particles, upregulation of recA , and cell filamentation. Pressure (200 MPa) or heat did not induce the Stx2-encoding prophage (Stx2-prophage). Overall, the quantification method developed in this study allowed investigation of prophage induction and physiological properties at the single-cell level. H 2 O 2 and acids mediate different pathways to induce Stx2-prophage. IMPORTANCE Induction of the Stx-prophage in STEC results in production of phage particles and Stx and thus relates to virulence as well as the transduction of virulence genes. This study developed a method for a detection of the induction of Stx-prophages at the single-cell level; membrane permeability and an indication of SOS response to environmental stress were additionally assessed. H 2 O 2 and mitomycin C induced expression of the prophage and activated a SOS response. In contrast, HCl and lactic acid induced the Stx-prophage but not the SOS response. The lifestyle of STEC exposes the organism to intestinal and extraintestinal environments that impose oxidative and acid stress. A more thorough understanding of the influence of food processing-related stressors on Stx-prophage expression thus facilitates control of STEC in food systems by minimizing prophage induction during food production and storage. Copyright © 2017 American Society for Microbiology.

Induction of Shiga Toxin-Encoding Prophage by Abiotic Environmental Stress in Food

PubMed Central

Fang, Yuan; Mercer, Ryan G.; McMullen, Lynn M.

2017-01-01

ABSTRACT The prophage-encoded Shiga toxin is a major virulence factor in Stx-producing Escherichia coli (STEC). Toxin production and phage production are linked and occur after induction of the RecA-dependent SOS response. However, food-related stress and Stx-prophage induction have not been studied at the single-cell level. This study investigated the effects of abiotic environmental stress on stx expression by single-cell quantification of gene expression in STEC O104:H4 Δstx2::gfp::ampr. In addition, the effect of stress on production of phage particles was determined. The lethality of stressors, including heat, HCl, lactic acid, hydrogen peroxide, and high hydrostatic pressure, was selected to reduce cell counts by 1 to 2 log CFU/ml. The integrity of the bacterial membrane after exposure to stress was measured by propidium iodide (PI). The fluorescent signals of green fluorescent protein (GFP) and PI were quantified by flow cytometry. The mechanism of prophage induction by stress was evaluated by relative gene expression of recA and cell morphology. Acid (pH < 3.5) and H2O2 (2.5 mM) induced the expression of stx2 in about 18% and 3% of the population, respectively. The mechanism of prophage induction by acid differs from that of induction by H2O2. H2O2 induction but not acid induction corresponded to production of infectious phage particles, upregulation of recA, and cell filamentation. Pressure (200 MPa) or heat did not induce the Stx2-encoding prophage (Stx2-prophage). Overall, the quantification method developed in this study allowed investigation of prophage induction and physiological properties at the single-cell level. H2O2 and acids mediate different pathways to induce Stx2-prophage. IMPORTANCE Induction of the Stx-prophage in STEC results in production of phage particles and Stx and thus relates to virulence as well as the transduction of virulence genes. This study developed a method for a detection of the induction of Stx-prophages at the single-cell level; membrane permeability and an indication of SOS response to environmental stress were additionally assessed. H2O2 and mitomycin C induced expression of the prophage and activated a SOS response. In contrast, HCl and lactic acid induced the Stx-prophage but not the SOS response. The lifestyle of STEC exposes the organism to intestinal and extraintestinal environments that impose oxidative and acid stress. A more thorough understanding of the influence of food processing-related stressors on Stx-prophage expression thus facilitates control of STEC in food systems by minimizing prophage induction during food production and storage. PMID:28778890

Treatment Outcomes for T4 Oropharyngeal Squamous Cell Carcinoma.

PubMed

Zenga, Joseph; Wilson, Michael; Adkins, Douglas R; Gay, Hiram A; Haughey, Bruce H; Kallogjeri, Dorina; Michel, Loren S; Paniello, Randal C; Rich, Jason T; Thorstad, Wade L; Nussenbaum, Brian

2015-12-01

Little is known about treatment outcomes for T4 oropharyngeal squamous cell carcinoma (OPSCC), particularly in the era of human papillomavirus (HPV)-related disease. To evaluate oncologic outcomes for T4 OPSCC treated with primary surgical and nonsurgical therapies. Retrospective cohort study of 131 patients from a single academic hospital, who were treated for T4a or T4b OPSCC (with any N stage and without distant metastatic disease at presentation) between 1998 and 2012 and had a minimum 2-year follow-up (the median follow-up time was 34.6 months). This study was conducted between January 1, 1998, and November 1, 2012. Sixty-nine patients underwent nonsurgical therapy, 47 (68%) of whom had p16-positive tumors. Nonsurgical treatment paradigms included induction chemotherapy followed by chemoradiotherapy (n = 36 [54%]), concurrent chemoradiotherapy (n = 29 [43%]), and induction chemotherapy followed by radiation therapy alone (n = 2 [3%]). Sixty-two patients underwent surgical treatment, 50 (81%) of whom had p16-positive tumors. Fifty-seven surgical patients (92%) received adjuvant therapy. Overall survival (OS) was the primary outcome measure. Secondary outcome measures included disease-specific survival (DSS), disease-free survival (DFS), 2-year gastrostomy and tracheostomy tube rates, and major complication rates. Significant baseline differences between the surgical vs nonsurgical groups included age (mean 59.8 vs 55.4 years [P = .005]), sex (male, 95% vs 84% [P = .04]), body mass index (<18.5 [calculated as weight in kilograms divided by height in meters squared], 3% vs 16% [P = .02]), and smoking history of 10 or more pack-years (48% vs 77% [P = .003]). For p16-positive patients, Kaplan-Meier estimates of OS, DSS, and DFS were significantly higher for surgically treated patients than for the nonsurgical group (χ(2)(1) = 7.335 for log-rank P = .007, χ(2)(1) = 8.607 for log-rank P = .003, and χ(2)(1) = 7.763 for log-rank P = .005, respectively). For p16-negative patients, Kaplan-Meier estimates of OS and DSS were higher for the surgical group but did not reach statistical significance (χ(2)(1) = 2.649 for log-rank P = .10 and χ(2)(1) = 2.077 for log-rank P = .15, respectively), while estimates of DFS were significantly higher for patients treated with primary surgery (χ(2)(1)= 3.869 for log-rank P = .049. In a multivariable Cox survival analysis, p16-positive immunohistochemical status had a significant positive association with OS (hazard ratio [HR], 0.55; 95% CI, 0.32-0.95 [P = .03]), DSS (HR, 0.45; 95% CI, 0.22-0.92 [P = .03]), and DFS (HR, 0.55; 95% CI, 0.32-0.95 [P = .03]), and nonsurgical treatment had a significant negative association with OS (HR, 2.79; 95% CI, 1.51-5.16 [P = .001]), DSS (HR, 3.38; 95% CI, 1.59-7.16 [P = .002]), and DFS (HR, 2.59; 95% CI, 1.51-4.45 [P = .001]). Primary surgical treatment may be associated with improved outcomes in patients with T4 OPSCC. p16 Immunohistochemical status remains a strong prognostic indicator even in patients with locally advanced disease.

Apparent resistivity for transient electromagnetic induction logging and its correction in radial layer identification

NASA Astrophysics Data System (ADS)

Meng, Qingxin; Hu, Xiangyun; Pan, Heping; Xi, Yufei

2018-04-01

We propose an algorithm for calculating all-time apparent resistivity from transient electromagnetic induction logging. The algorithm is based on the whole-space transient electric field expression of the uniform model and Halley's optimisation. In trial calculations for uniform models, the all-time algorithm is shown to have high accuracy. We use the finite-difference time-domain method to simulate the transient electromagnetic field in radial two-layer models without wall rock and convert the simulation results to apparent resistivity using the all-time algorithm. The time-varying apparent resistivity reflects the radially layered geoelectrical structure of the models and the apparent resistivity of the earliest time channel follows the true resistivity of the inner layer; however, the apparent resistivity at larger times reflects the comprehensive electrical characteristics of the inner and outer layers. To accurately identify the outer layer resistivity based on the series relationship model of the layered resistance, the apparent resistivity and diffusion depth of the different time channels are approximately replaced by related model parameters; that is, we propose an apparent resistivity correction algorithm. By correcting the time-varying apparent resistivity of radial two-layer models, we show that the correction results reflect the radially layered electrical structure and the corrected resistivities of the larger time channels follow the outer layer resistivity. The transient electromagnetic fields of radially layered models with wall rock are simulated to obtain the 2D time-varying profiles of the apparent resistivity and corrections. The results suggest that the time-varying apparent resistivity and correction results reflect the vertical and radial geoelectrical structures. For models with small wall-rock effect, the correction removes the effect of the low-resistance inner layer on the apparent resistivity of the larger time channels.

Support vector regression to predict porosity and permeability: Effect of sample size

NASA Astrophysics Data System (ADS)

Al-Anazi, A. F.; Gates, I. D.

2012-02-01

Porosity and permeability are key petrophysical parameters obtained from laboratory core analysis. Cores, obtained from drilled wells, are often few in number for most oil and gas fields. Porosity and permeability correlations based on conventional techniques such as linear regression or neural networks trained with core and geophysical logs suffer poor generalization to wells with only geophysical logs. The generalization problem of correlation models often becomes pronounced when the training sample size is small. This is attributed to the underlying assumption that conventional techniques employing the empirical risk minimization (ERM) inductive principle converge asymptotically to the true risk values as the number of samples increases. In small sample size estimation problems, the available training samples must span the complexity of the parameter space so that the model is able both to match the available training samples reasonably well and to generalize to new data. This is achieved using the structural risk minimization (SRM) inductive principle by matching the capability of the model to the available training data. One method that uses SRM is support vector regression (SVR) network. In this research, the capability of SVR to predict porosity and permeability in a heterogeneous sandstone reservoir under the effect of small sample size is evaluated. Particularly, the impact of Vapnik's ɛ-insensitivity loss function and least-modulus loss function on generalization performance was empirically investigated. The results are compared to the multilayer perception (MLP) neural network, a widely used regression method, which operates under the ERM principle. The mean square error and correlation coefficients were used to measure the quality of predictions. The results demonstrate that SVR yields consistently better predictions of the porosity and permeability with small sample size than the MLP method. Also, the performance of SVR depends on both kernel function type and loss functions used.

CYP1A2 in a smoking and a non-smoking population; correlation of urinary and salivary phenotypic ratios.

PubMed

Woolridge, Helen; Williams, John; Cronin, Anna; Evans, Nicola; Steventon, Glyn B

2004-01-01

The use of caffeine as a probe for CYP1A2 phenotyping has been extensively investigated over the last 25 years. Numerous metabolic ratios have been employed and various biological fluids analysed for caffeine and its metabolites. These investigations have used non-smoking, smoking and numerous disease populations to investigate the role of CYP1A2 in possible disease aetiology and for induction and inhibition studies in vivo using dietary, environmental and pharmaceutical compounds. This investigation found that the 17X/137X CYP1A2 metabolic ratio in a 5 h saliva sample and 0-5 h urine collection was not normally distributed in both a non-smoking and a smoking population. The urinary and salivary CYP1A2 metabolic ratio was log normally distributed in the non-smoking population but the smoking population showed a bi- (or tri-)modal distribution on log transformation of both the urinary and salivary CYP1A2 metabolic ratios. The CYP1A2 metabolic ratios were significantly higher in the smoking population compared to the non-smoking population when both the urinary and salivary CYP1A2 metabolic ratios were analysed. These results indicate that urinary flow rate was not a factor in the variation in CYP1A2 phenotype in the non-smoking and smoking populations studied here. The increased CYP1A2 activity in the smoking population was probably due to induction of the CYP1A2 gene via the Ah receptor causing an increase in the concentration of CYP1A2 protein.

[Lung Resection after Definitive and Neo-Adjuvant Chemoradiation for Stage IIIA/B Locally Advanced Non-Small Cell Lung Cancer: a Retrospective Analysis].

PubMed

Schreiner, Waldemar; Gavrychenkova, Sofiia; Dudek, Wojciech; Lettmaier, Sebastian; Rieker, Ralf; Fietkau, Rainer; Sirbu, Horia

2018-06-01

The outcomes of so called "salvage" resections after definitive chemoradiation vs. curative resections after neoadjuvant chemoradiation therapy (IT-resection) in patients with stage IIIA/B locally advanced non-small cell lung cancer have rarely been compared. The aim of our study was to compare perioperative results, postoperative and recurrence-free survival and to identify relevant prognostic survival factors for both therapy strategies. Between June 2008 and May 2017, 43 patients underwent pulmonary resection following induction therapy (group 1) and 14 patients underwent salvage resection after definitive chemoradiation (group 2). Retrospective analysis was performed of demographic factors, tumour stage and location, initial therapy, preoperative regression status, perioperative morbidity and mortality, postoperative and recurrence-free survival. In group 2, significantly higher radiation dose was applied (p < 0.001) and the interval between chemoradiation and lung resection was significantly longer (p = 0.02). In addition, significantly higher perioperative blood loss and more frequent blood transfusions were noted (p = 0.003 and 0.005, respectively). Perioperative morbidity and mortality were statistically comparable in the two groups (p = 0.72 and 0.395, respectively). Postoperative 5 year survival in group 1 was 55%, in group 2 48% (log-rank p = 0.353). Five year recurrence-free survival in group 1 was 53%, in group 2 42% (log-rank p = 0.180). Diffuse metastasis occurred mostly in group 2, whereas in group 1 oligometastasis was more frequently noted. Postoperative outcome after salvage resection seems statistically comparable to results following curative resection after induction therapy. Diffuse distant metastasis is frequently noted. Careful patient selection is required. Georg Thieme Verlag KG Stuttgart · New York.

ANDRILL Borehole AND-1B: Well Log Analysis of Lithofacies and Glacimarine Cycles.

NASA Astrophysics Data System (ADS)

Jackolski, C. L.; Williams, T.; Powell, R. D.; Jarrard, R.; Morin, R. H.; Talarico, F. M.; Niessen, F.; Kuhn, G.

2008-12-01

During the 2006-2007 austral summer, the Antarctic geological drilling program ANDRILL recovered cores of sedimentary rock from a 1285-m-deep borehole below the McMurdo Ice Shelf. Well logging instruments were deployed to a depth of 1017 mbsf after core recovery. This study focuses on two intervals of the AND-1B borehole: upper HQ (238-343 mbsf; Pliocene) and NQ (698-1017 mbsf; upper Miocene), which were logged with natural gamma ray, induction resistivity and magnetic susceptibility tools. To understand how the well logs fit into a more complete physical properties data set, we performed factor and cluster analyses on a suite of well logs and core logs in the upper HQ and NQ intervals. In both intervals, factor analysis groups resistivity and core P-velocity into a factor that we interpret as being inversely proportional to porosity. It also groups natural gamma and potassium (from the XRF core scanner) into a factor that we interpret as a particle-size or lithology index. An additional factor in the NQ interval, influenced by clast number and magnetic susceptibility, distinguishes subglacial diamictites from other lithofacies. The factors in each interval (2 in HQ, 3 in NQ) are used as input to cluster analysis. The results are log data objectively organized into clusters, or electrofacies. We compare these electrofacies to the lithofacies, well logs and unconformity-bounded glacimarine cycles of AND-1B. Patterns in the glacimarine cycles are observed in the well logs and electrofacies. In the NQ glacimarine sediments, an electrofacies pattern is produced between subglacial diamictites at the bottom of each sequence and the glacial retreat facies above. Subglacial diamictites have higher values for the additional NQ factor, corresponding to clast number and magnetic susceptibility, than the muds and sands that form the retreat facies. Differences in the porosity factor are not observed in any electrofacies pattern in the NQ interval, but subtle patterns in the resistivity well log are observed. Subglacial diamictites have greater resistivities than most retreat facies. In the HQ interval, there is only one glacimarine cycle that resembles those in the NQ interval, and most of the interval is subglacial or ice-proximal diamictite. There are only two and a half cycles in the HQ interval, but they contain an incipient electrofacies pattern. In the lower two cycles, the potassium/gamma factor is low at the bottom and high toward the top, and porosity, as indicated by the porosity factor, is low at the bottom and high toward the top. Throughout most of the HQ interval, potassium and natural gamma correlate with porosity. Two exceptions are the lower half of the top cycle, in which resistivity increases toward the top, and the two diatomite beds at the top of the two lower cycles, in which potassium/gamma is low and porosity is very high.

Integrated Geophysical Investigation of Preferential Flow Paths at the Former Tyson Valley Powder Farm near Eureka, Missouri, May 2006

USGS Publications Warehouse

Burton, Bethany L.; Ball, Lyndsay B.; Stanton, Gregory P.; Hobza, Christopher M.

2009-01-01

In May 2006, the U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, conducted surface and borehole geophysical surveys at the former Tyson Valley Powder Farm near Eureka, Mo., to identify preferential pathways for potential contaminant transport along the bedrock surface and into dissolution-enhanced fractures. The Tyson Valley Powder Farm was formerly used as a munitions storage and disposal facility in the 1940s and 1950s, and the site at which the surveys were performed was a disposal area for munitions and waste solvents such as trichloroethylene and dichloroethylene. Direct-current resistivity and seismic refraction data were acquired on the surface; gamma, electromagnetic induction, and full waveform sonic logs were acquired in accessible boreholes. Through the combined interpretation of the seismic refraction tomographic and resistivity inversion results and borehole logs, inconsistencies in the bedrock surface were identified that may provide horizontal preferential flow paths for dense nonaqueous phase liquid contaminants. These results, interpreted and displayed in georeferenced three-dimensional space, should help to establish more effective monitoring and remediation strategies.

Shock Initiation Behavior of PBXN-9 Determined by Gas Gun Experiments

NASA Astrophysics Data System (ADS)

Sanchez, N. J.; Gustavsen, R. L.; Hooks, D. E.

2009-12-01

The shock to detonation transition was evaluated in the HMX based explosive PBXN-9 by a series of light-gas gun experiments. PBXN-9 consists of 92 wt% HMX, 2wt% Hycar 4054 & 6 wt&percent; dioctyl adipate with a density of 1.75 g/cm3 and 0.8&% voids. The experiments were designed to understand the specifics of wave evolution and the run distance to detonation as a function of input shock pressure. These experiments were conducted on gas guns in order to vary the input shock pressure accurately. The primary diagnostics were embedded magnetic gauges, which are based on Faraday's law of induction, and Photon Doppler Velocimetry (PDV). The run distance to detonation vs. shock pressure, or "Pop plot," was redefined as log(X) = 2.14-1.82 log (P), which is substantially different than previous data. The Hugoniot was refined as Us = 2.32+2.211 Up. This data will be useful for the development of predictive models for the safety and performance of PBXN-9 along with providing increased understanding of HMX based explosives in varying formulations.

Shock initiation behavior of PBXN-9 determined by gas gun experiments

NASA Astrophysics Data System (ADS)

Sanchez, Nathaniel; Gustavsen, Richard; Hooks, Daniel

2009-06-01

The shock to detonation transition was evaluated in the HMX based explosive PBXN-9 by a series of light-gas gun experiments. PBXN-9 consists of 92 wt% HMX, 2wt% Hycar 4054 & 6 wt% dioctyl adipate with a density of 1.75 g/cm^3 and 0.8% voids. The experiments were designed to understand the specifics of wave evolution and the run distance to detonation as a function of input shock pressure. These experiments were conducted on gas guns in order to vary the input shock pressure accurately. The primary diagnostics are embedded magnetic gauges which are based on Faraday's law of induction along with photon Doppler velocimetry (PDV). The run distance to detonation vs. shock pressure, or ``Pop plot,'' was redefined as log (X*) = 2.14 -- 1.82 log (P), which is substantially different than previous data. The Hugoniot was refined as Us = 2.32 + 2.21 Up. This data will be useful for the development of predictive models for the safety and performance of PBXN-9 in addition to providing an increased understanding of HMX based explosives in varying formulations.

Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710

PubMed Central

Moser, Barry; Stock, Wendy; Gallagher, Robert E.; Willman, Cheryl L.; Stone, Richard M.; Rowe, Jacob M.; Coutre, Steven; Feusner, James H.; Gregory, John; Couban, Stephen; Appelbaum, Frederick R.; Tallman, Martin S.; Larson, Richard A.

2010-01-01

Arsenic trioxide (As2O3) is a highly effective treatment for patients with relapsed acute promyelocytic leukemia (APL); its role as consolidation treatment for patients in first remission has not been defined. We randomized 481 patients (age ≥ 15 years) with untreated APL to either a standard induction regimen of tretinoin, cytarabine, and daunorubicin, followed by 2 courses of consolidation therapy with tretinoin plus daunorubicin, or to the same induction and consolidation regimen plus two 25-day courses of As2O3 consolidation immediately after induction. After consolidation, patients were randomly assigned to one year of maintenance therapy with either tretinoin alone or in combination with methotrexate and mercaptopurine. Ninety percent of patients on each arm achieved remission and were eligible to receive their assigned consolidation therapy. Event-free survival, the primary end point, was significantly better for patients assigned to receive As2O3 consolidation, 80% compared with 63% at 3 years (stratified log-rank test, P < .0001). Survival, a secondary end point, was better in the As2O3 arm, 86% compared with 81% at 3 years (P = .059). Disease-free survival, a secondary end point, was significantly better in the As2O3 arm, 90% compared with 70% at 3 years (P < .0001). The addition of As2O3 consolidation to standard induction and consolidation therapy significantly improves event-free and disease-free survival in adults with newly diagnosed APL. This trial was registered at clinicaltrials.gov (NCT00003934). PMID:20705755

Castor oil as a natural alternative to labor induction: A retrospective descriptive study.

PubMed

DeMaria, Andrea L; Sundstrom, Beth; Moxley, Grace E; Banks, Kendall; Bishop, Ashlan; Rathbun, Lesley

2018-04-01

To describe birthing outcomes among women who consumed castor oil cocktail as part of a freestanding birth center labor induction protocol. De-identified data from birth logs and electronic medical records were entered into SPSS Statistics 22.0 for analysis for all women who received the castor oil cocktail (n=323) to induce labor between January 2008 and May 2015 at a birth center in the United States. Descriptive statistics were analyzed for trends in safety and birthing outcomes. Of the women who utilized the castor oil cocktail to stimulate labor, 293 (90.7%) birthed vaginally at the birth center or hospital. The incidence of maternal adverse effects (e.g., nausea, vomiting, extreme diarrhea) was less than 7%, and adverse effects of any kind were reported in less than 15% of births. An independent sample t-test revealed that parous women were more likely to birth vaginally at the birth center after using the castor oil cocktail than their nulliparous counterparts (p<.010), while gestational age (p=.26), woman's age (p=.23), and body mass index (p=.28) were not significantly associated. Nearly 91% of women in the study who consumed the castor oil cocktail to induce labor were able to give birth vaginally with little to no maternal or fetal complications. Findings indicate further research is needed to compare the safety and effectiveness of natural labor induction methodologies, including castor oil, to commonly used labor induction techniques in a prospective study or clinical trial. Copyright © 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

KSC-06pd0791

NASA Image and Video Library

2006-05-06

KENNEDY SPACE CENTER, FLA. - Charles F. Bolden Jr. (right) accepts congratulations from Al Worden, U.S. Astronaut Hall of Fame member and chairman of the Astronaut Scholarship Foundation. The occasion is the 2006 induction ceremony for the U.S. Astronaut Hall of Fame, held in the Apollo/Saturn V Center. The inductees for 2006 are former NASA astronauts Bolden, Henry "Hank" Hartsfield Jr. and Brewster H. Shaw Jr. Bolden flew on four space shuttle missions including STS-61C, STS-31, STS-45 and STS-60, logging 680 hours in space. The U.S. Astronaut Hall of Fame now includes 63 space explorers. Photo credit: NASA/Kim Shiflett

3D Extended Logging for Geothermal Resources: Field Trials with the Geo-Bilt System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mallan, R; Wilt, M; Kirkendall, B

2002-05-29

Geo-BILT (Geothermal Borehole Induction Logging Tool) is an extended induction logging tool designed for 3D resistivity imaging around a single borehole. The tool was developed for deployment in high temperature geothermal wells under a joint program funded by the California Energy Commission, Electromagnetic Instruments (EMI) and the U.S. Department of Energy. EM1 was responsible for tool design and manufacture, and numerical modeling efforts were being addressed at Lawrence Livermore Laboratory (LLNL) and other contractors. The field deployment was done by EM1 and LLNL. The tool operates at frequencies from 2 to 42 kHz, and its design features a series ofmore » three-component magnetic sensors offset at 2 and 5 meters from a three-component magnetic source. The combined package makes it possible to do 3D resistivity imaging, deep into the formation, from a single well. The manufacture and testing of the tool was completed in spring of 2001, and the initial deployment of Geo-BILT occurred in May 2001 at the Lost Hills oil field in southern California at leases operated by Chevron USA. This site was chosen for the initial field test because of the favorable geological conditions and the availability of a number of wells suitable for tool deployment. The second deployment occurred in April 2002 at the Dixie Valley geothermal field, operated by Caithness Power LLC, in central Nevada. This constituted the first test in a high temperature environment. The Chevron site features a fiberglass-cased observation well in the vicinity of a water injector. The injected water, which is used for pressure maintenance and for secondary sweep of the heavy oil formation, has a much lower resistivity than the oil bearing formation. This, in addition to the non-uniform flow of this water, creates a 3D resistivity structure, which is analogous to conditions produced from flowing fractures adjacent to geothermal boreholes. Therefore, it is an excellent site for testing the 3D capability of the tool in a low risk environment. The Dixie Valley site offered an environment where the tool could locate near-well fractures associated with steam development. The Lost Hills field measurements yielded a data set suitable for 3D imaging. The Geo-BLT data corresponded to existing conventional logging data and showed clear indications, in several depth intervals, of near-well 3D structure. Subsequent 3D inversion of these data produced a model consistent with non-planar water flow in specific layers. The Dixie Valley measurements identified structures associated with dike intrusions and water inflow at particular depths. Preliminary analysis suggests these structures are steeply dipping, which is consistent with the geology.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poutsma, Marvin L.

Recently we presented structure-reactivity correlations for the gas-phase ambient-temperature rate constants for hydrogen abstraction from sp 3-hybridized carbon by chlorine atom and hydroxyl radical (Cl•/HO• + HCR 3 → HCl/HOH + •CR 3); the reaction enthalpy effect was represented by the independent variable Δ rH and the polar effect by the independent variables F and R, the Hammett constants for field/inductive and resonance effects. Both these reactions are predominantly exothermic and have early transition states. Here we present a parallel treatment for Br• whose reaction is significantly endothermic with a correspondingly late transition state. In spite of lower expectations becausemore » the available data base is less extensive and much more scattered and because long temperature extrapolations are often required, the resulting least-squares fit (log k 298,Br = –0.147 Δ rH –4.32 ΣF –4.28 ΣR –12.38 with r 2 = 0.92) was modestly successful and useful for initial predictions. The coefficient of Δ rH was ~4-fold greater, indicative of the change from an early to a late transition state; meanwhile the sizable coefficients of ΣF and ΣR indicate the persistence of the polar effect. Although the mean unsigned deviation of 0.79 log k 298 units is rather large, it must be considered in the context of a total span of over 15 log units in the data set. Lastly, the major outliers are briefly discussed.« less

Extension of Structure-Reactivity Correlations for the Hydrogen Abstraction Reaction by Bromine Atom and Comparison to Chlorine Atom and Hydroxyl Radical.

PubMed

Poutsma, Marvin L

2016-01-21

Recently we presented structure-reactivity correlations for the gas-phase ambient-temperature rate constants for hydrogen abstraction from sp(3)-hybridized carbon by chlorine atom and hydroxyl radical (Cl•/HO• + HCR3 → HCl/HOH + •CR3); the reaction enthalpy effect was represented by the independent variable ΔrH and the "polar effect" by the independent variables F and R, the Hammett constants for field/inductive and resonance effects. Both these reactions are predominantly exothermic and have early transition states. Here, we present a parallel treatment for Br• whose reaction is significantly endothermic with a correspondingly late transition state. Despite lower expectations because the available database is less extensive and much more scattered and because long temperature extrapolations are often required, the resulting least-squares fit (log k298,Br = -0.147 ΔrH - 4.32 ΣF - 4.28 ΣR - 12.38 with r(2) = 0.92) was modestly successful and useful for initial predictions. The coefficient of ΔrH was ∼4-fold greater, indicative of the change from an early to a late transition state; meanwhile the sizable coefficients of ΣF and ΣR indicate the persistence of the "polar effect". Although the mean unsigned deviation of 0.79 log k298 units is rather large, it must be considered in the context of a total span of over 15 log units in the data set. The major outliers are briefly discussed.

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

PubMed Central

Heiser, Axel; Coleman, Doris; Dannull, Jens; Yancey, Donna; Maurice, Margaret A.; Lallas, Costas D.; Dahm, Philipp; Niedzwiecki, Donna; Gilboa, Eli; Vieweg, Johannes

2002-01-01

Autologous dendritic cells (DCs) transfected with mRNA encoding prostate-specific antigen (PSA) are able to stimulate potent, T cell–mediated antitumor immune responses in vitro. A phase I trial was performed to evaluate this strategy for safety, feasibility, and efficacy to induce T cell responses against the self-protein PSA in patients with metastatic prostate cancer. In 13 study subjects, escalating doses of PSA mRNA–transfected DCs were administered with no evidence of dose-limiting toxicity or adverse effects, including autoimmunity. Induction of PSA-specific T cell responses was consistently detected in all patients, suggesting in vivo bioactivity of the vaccine. Vaccination was further associated with a significant decrease in the log slope PSA in six of seven subjects; three patients that could be analyzed exhibited a transient molecular clearance of circulating tumor cells. The demonstration of vaccine safety, successful in vivo induction of PSA-specific immunity, and impact on surrogate clinical endpoints provides a scientific rationale for further clinical investigation of RNA-transfected DCs in the treatment of human cancer. PMID:11828001

Postinduction Minimal Residual Disease Predicts Outcome and Benefit From Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia With NPM1 Mutation: A Study by the Acute Leukemia French Association Group.

PubMed

Balsat, Marie; Renneville, Aline; Thomas, Xavier; de Botton, Stéphane; Caillot, Denis; Marceau, Alice; Lemasle, Emilie; Marolleau, Jean-Pierre; Nibourel, Olivier; Berthon, Céline; Raffoux, Emmanuel; Pigneux, Arnaud; Rodriguez, Céline; Vey, Norbert; Cayuela, Jean-Michel; Hayette, Sandrine; Braun, Thorsten; Coudé, Marie Magdeleine; Terre, Christine; Celli-Lebras, Karine; Dombret, Hervé; Preudhomme, Claude; Boissel, Nicolas

2017-01-10

Purpose This study assessed the prognostic impact of postinduction NPM1-mutated ( NPM1m) minimal residual disease (MRD) in young adult patients (age, 18 to 60 years) with acute myeloid leukemia, and addressed the question of whether NPM1m MRD may be used as a predictive factor of allogeneic stem cell transplantation (ASCT) benefit. Patients and Methods Among 229 patients with NPM1m who were treated in the Acute Leukemia French Association 0702 (ALFA-0702) trial, MRD evaluation was available in 152 patients in first remission. Patients with nonfavorable AML according to the European LeukemiaNet (ELN) classification were eligible for ASCT in first remission. Results After induction therapy, patients who did not achieve a 4-log reduction in NPM1m peripheral blood-MRD (PB-MRD) had a higher cumulative incidence of relapse (subhazard ratio [SHR], 5.83; P < .001) and a shorter overall survival (OS; hazard ratio [HR], 10.99; P < .001). In multivariable analysis, an abnormal karyotype, the presence of FLT3-internal tandem duplication (ITD), and a < 4-log reduction in PB-MRD were significantly associated with a higher relapse incidence and shorter OS. In the subset of patients with FLT3-ITD, only age, white blood cell count, and < 4-log reduction in PB-MRD, but not FLT3-ITD allelic ratio, remained of significant prognostic value. In these patients with nonfavorable AML according to European LeukemiaNet, disease-free survival and OS were significantly improved by ASCT in those with a < 4-log reduction in PB-MRD. This benefit was not observed in those with a > 4-log reduction in PB-MRD, with a significant interaction between ASCT effect and PB-MRD response ( P = .024 and .027 for disease-free survival and OS, respectively). Conclusion Our study supports the strong prognostic significance of early NPM1m PB-MRD, independent of the cytogenetic and molecular context. Moreover, NPM1m PB-MRD may be used as a predictive factor for ASCT indication.

Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).

PubMed

Carrieri, Patrizia Maria; Michel, Laurent; Lions, Caroline; Cohen, Julien; Vray, Muriel; Mora, Marion; Marcellin, Fabienne; Spire, Bruno; Morel, Alain; Roux, Perrine

2014-01-01

Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC. In this study, registered at ClinicalTrials.Gov (NCT00657397), opioid-dependent individuals not on methadone treatment for at least one month or receiving buprenorphine but needing to switch were randomly assigned to start methadone in PC (N = 155) or in SC (N = 66) in 10 sites in France. Visits were scheduled at months M0, M3, M6 and M12. The primary outcome was self-reported abstinence from street-opioids at 12 months (M12) (with an underlying 15% non-inferiority hypothesis for PC). Secondary outcomes were abstinence during follow-up, engagement in treatment (i.e. completing the induction period), retention and satisfaction with the explanations provided by the physician. Primary analysis used intention to treat (ITT). Mixed models and the log-rank test were used to assess the arm effect (PC vs. SC) on the course of abstinence and retention, respectively. In the ITT analysis (n = 155 in PC, 66 in SC), which compared the proportions of street-opioid abstinent participants, 85/155 (55%) and 22/66 (33%) of the participants were classified as street-opioid abstinent at M12 in PC and SC, respectively. This ITT analysis showed the non-inferiority of PC (21.5 [7.7; 35.3]). Engagement in treatment and satisfaction with the explanations provided by the physician were significantly higher in PC than SC. Retention in methadone and abstinence during follow-up were comparable in both arms (p = 0.47, p = 0.39, respectively). Under appropriate conditions, methadone induction in primary care is feasible and acceptable to both physicians and patients. It is as effective as induction in specialized care in reducing street-opioid use and ensuring engagement and retention in treatment for opioid dependence. Number Eudract 2008-001338-28; ClinicalTrials.gov: NCT00657397; International Standard Randomized Controlled Trial Number Register ISRCTN31125511.

Investigation of Global Lightning using Schumann Resonances measured by High Frequency Induction Coil Magnetometers in the UK

NASA Astrophysics Data System (ADS)

Beggan, C.; Gabillard, T.; Swan, A.; Flower, S. M.; Thomson, A. W.

2012-12-01

In June 2012, the British Geological Survey Geomagnetism team installed two high frequency (100 Hz) induction coil magnetometers at the Eskdalemuir Observatory, in the Scottish Borders of the United Kingdom. The induction coils permit us to measure the very rapid changes of the magnetic field. The Eskdalemuir Observatory is one of the longest running geophysical sites in the UK (beginning operation in 1904) and is located in a rural valley with a quiet magnetic environment. The data output from the induction coils are digitized and logged onsite before being collected once per hour and sent to the Edinburgh office via the Internet. We intend to run the coils as a long term experiment. We present initial results from first five months of data. Analysis of spectrograms and power spectral density plots in the frequency band of 3-40 Hz from the coils show diffuse bands of peak power around 7.8 Hz, 14.3 Hz, 20.8 Hz, 27 Hz, 34 Hz and 39Hz related to the global Schumann resonances. We also detect a strong narrow peak at 25 Hz, which is a harmonic of the UK electrical power system. There are a number of features in the data that we wish to investigate, including the diurnal and seasonal variation of the Schumann resonances. For example, it has been suggested that lightning activity is related to climate variability in the tropics and that perhaps Madden-Julian Oscillations (MJO) or El Niño Southern Oscillation (ENSO)-like correlations are detectable within the data. On longer timescales, we will look for solar cycle and climate variations. We also wish to note that the data is freely available on request to the community.

P-glycoprotein expression in Ehrlich ascites tumour cells after in vitro and in vivo selection with daunorubicin.

PubMed Central

Nielsen, D.; Eriksen, J.; Maare, C.; Jakobsen, A. H.; Skovsgaard, T.

1998-01-01

Fluctuation analysis experiments were performed to assess whether selection or induction determines expression of P-glycoprotein and resistance in the murine Ehrlich ascites tumour cell line (EHR2) after exposure to daunorubicin. Thirteen expanded populations of EHR2 cells were exposed to daunorubicin 7.5 x 10(-9) M or 10(-8) M for 2 weeks. Surviving clones were scored and propagated. Only clones exposed to daunorubicin 7.5 x 10(-9) M could be expanded for investigation. Drug resistance was assessed by the tetrazolium dye (MTT) cytotoxicity assay. Western blot was used for determination of P-glycoprotein. Compared with EHR2, the variant cells were 2.5- to 5.2-fold resistant to daunorubicin (mean 3.6-fold). P-glycoprotein was significantly increased in 11 of 25 clones (44%). Analysis of variance supported the hypothesis that spontaneous mutations conferred drug resistance in EHR2 cells exposed to daunorubicin 7.5 x 10(-9) M. At this level (5 log cell killing) of drug exposure, the mutation rate was estimated at 4.1 x 10(-6) per cell generation. In contrast, induction seemed to determine resistance in EHR2 cells in vitro exposed to daunorubicin 10(-8) M. The revertant EHR2/0.8/R was treated in vivo with daunorubicin for 24 h. After treatment, P-glycoprotein increased in EHR2/0.8/R (sevenfold) and the cell line developed resistance to daunorubicin (12-fold), suggesting that in EHR2/0.8/R the mdr1 gene was activated by induction. In conclusion, our study demonstrates that P-glycoprotein expression and daunorubicin resistance are primarily acquired by selection of spontaneously arising mutants. However, under certain conditions the mdr1 gene may be activated by induction. PMID:9820176

Long-term outcome of intravitreal pegaptanib sodium as maintenance therapy in Japanese patients with neovascular age-related macular degeneration.

PubMed

Inoue, Maiko; Kadonosono, Kazuaki; Arakawa, Akira; Yamane, Shin; Ishibashi, Tatsuro

2015-05-01

To evaluate the results of a 3-year follow-up of intravitreal pegaptanib sodium injection as maintenance therapy for the treatment of neovascular age-related macular degeneration (AMD) in Japanese patients. In this prospective, uncontrolled interventional study, 20 eyes of 19 patients with treatment-naïve AMD who had received 3 consecutive monthly injections of 0.5 mg/0.05 mL ranibizumab as the induction treatment and had shown clinical/anatomical improvement were enrolled. An intravitreal injection of 0.3 mg/0.09 mL pegaptanib sodium was administered as the maintenance therapy every 6 weeks. Booster treatments using ranibizumab were allowed if clinical deterioration was judged to be present. The primary outcome measures were the best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) as evaluated using spectral-domain optical coherence tomography. Sixteen of the 20 eyes (80 %) were assessed at the 3-year follow-up. The mean logMAR BCVA improved significantly from 0.56 ± 0.31 before the induction treatment to 0.24 ± 0.25 at baseline (P < 0.001) and was well maintained at 156 weeks (0.25 ± 0.28, P = 0.938). Moreover, the mean CFT also decreased significantly from 346 ± 111 μm before the induction treatment to 232 ± 54 μm at baseline (P < 0.001) and was well preserved at 156 weeks (210 ± 59 μm, P = 0.278). Thirteen eyes (81.3 %) received an unscheduled booster treatment, and no severe systemic or ocular side effects occurred during follow-up. Intravitreal pegaptanib sodium injection as the maintenance therapy was effective in stabilizing the vision of patients with AMD in whom induction treatment led to improved BCVA, as evaluated at the 3-year follow-up.

Towards the establishment of a general rate law for gypsum nucleation

NASA Astrophysics Data System (ADS)

Reznik, Itay J.; Ganor, Jiwchar; Gruber, Chen; Gavrieli, Ittai

2012-05-01

Gypsum nucleation kinetics from a wide range of chemical compositions (1.45 < Ca2+/SO42- < 115), ionic strengths (I = 2.5-10 m) and saturation state with respect to gypsum (Ωgyp = 1.07-8.4) were examined in batch experiments containing mixtures of Ca2+-rich Dead Sea brine and SO42-rich seawater with or without addition of extra Na2SO4 and CaCl2·2H2O. The induction times attained in the present study were compiled together with literature values from experiments carried out under significantly different conditions (synthetic NaCl solutions; I = 0.09-6.3 m; Ca2+/SO42- = 1; Ωgyp:1.59-7.76). Despite the variability in the experimental solutions, a single rate law based on classic nucleation theory was formulated to describe the induction times from more than 80 experiments: logT=log{1}/{3.17·Cs·exp{-}7.08ln2Ω}+0.072·Cs·exp-{1.426}/{ln2Ω} where Tind is the induction time, Cs is the solubility of gypsum and Ω is the saturation state with respect to gypsum. The rate law provides Tind for gypsum precipitation from aqueous solutions at 25 °C, containing no synthetic antiscalants or catalysts, within a 95% confidence interval within a factor of 5. Based on this rate law, we show that at present most of the precipitation of gypsum from the Dead Sea brine occurs following significant evaporation in the industrial evaporation ponds and not in the Dead Sea itself. Whereas Tind in Dead Sea brines is very long (on the order of 3 years), the evaporation of brine in the industrial ponds leads to increased Ω values, and thus to short Tind in the order of a few days. However, if seawater or reject brine from seawater desalinization will be introduced to the Dead Sea to restore its declining level, Tind will be significantly reduced and gypsum nucleation and precipitation will occur. For evaporated seawater, the proposed rate law predicts that even though saturation is obtained when seawater is evaporated by a factor of 2.8, gypsum will nucleate at reasonable times (few years) only when seawater are evaporated by a factor of ˜3.3.

Passive acquisition of CLIPS rules

NASA Technical Reports Server (NTRS)

Kovarik, Vincent J., Jr.

1991-01-01

The automated acquisition of knowledge by machine has not lived up to expectations, and knowledge engineering remains a human intensive task. Part of the reason for the lack of success is the difference in the cognitive focus of the expert. The expert must shift his or her focus from the subject domain to that of the representation environment. In doing so this cognitive shift introduces opportunity for errors and omissions. Presented here is work that observes the expert interact with a simulation of the domain. The system logs changes in the simulation objects and the expert's actions in response to those changes. This is followed by the application of inductive reasoning to move the domain specific rules observed to general domain rules.

Improving our understanding of hydraulic-electrical relations: A case study of the surficial aquifer in Emirate Abu Dhabi

USGS Publications Warehouse

Ikard, Scott; Kress, Wade

2016-01-01

Transmissivity is a bulk hydraulic property that can be correlated with bulk electrical properties of an aquifer. In aquifers that are electrically-resistive relative to adjacent layers in a horizontally stratified sequence, transmissivity has been shown to correlate with bulk transverse resistance. Conversely, in aquifers that are electrically-conductive relative to adjacent layers, transmissivity has been shown to correlate with bulk longitudinal conductance. In both cases, previous investigations have relied on small datasets (on average less than eight observations) that have yielded coefficients of determination (R2) that are typically in the range of 0.6 to 0.7 to substantiate these relations. Compared to previous investigations, this paper explores hydraulic-electrical relations using a much larger dataset. Geophysical data collected from 26 boreholes in Emirate Abu Dhabi, United Arab Emirates, are used to correlate transmissivity modeled from neutron porosity logs to the bulk electrical properties of the surficial aquifer that are computed from deep-induction logs. Transmissivity is found to be highly correlated with longitudinal conductance. An R2 value of 0.853 is obtained when electrical effects caused by variations in pore-fluid salinity are taken into consideration.

Differences between co-cultures and monocultures in testing the toxicity of particulate matter derived from log wood and pellet combustion.

PubMed

Kasurinen, Stefanie; Happo, Mikko S; Rönkkö, Teemu J; Orasche, Jürgen; Jokiniemi, Jorma; Kortelainen, Miika; Tissari, Jarkko; Zimmermann, Ralf; Hirvonen, Maija-Riitta; Jalava, Pasi I

2018-01-01

In vitro studies with monocultures of human alveolar cells shed deeper knowledge on the cellular mechanisms by which particulate matter (PM) causes toxicity, but cannot account for mitigating or aggravating effects of cell-cell interactions on PM toxicity. We assessed inflammation, oxidative stress as well as cytotoxic and genotoxic effects induced by PM from the combustion of different types of wood logs and softwood pellets in three cell culture setups: two monocultures of either human macrophage-like cells or human alveolar epithelial cells, and a co-culture of these two cell lines. The adverse effects of the PM samples were compared between these setups. We detected clear differences in the endpoints between the mono- and co-cultures. Inflammatory responses were more diverse in the macrophage monoculture and the co-culture compared to the epithelial cells where only an increase of IL-8 was detected. The production of reactive oxygen species was the highest in epithelial cells and macrophages seemed to have protective effects against oxidative stress from the PM samples. With no metabolically active cells at the highest doses, the cytotoxic effects of the PM samples from the wood log combustion were far more pronounced in the macrophages and the co-culture than in the epithelial cells. All samples caused DNA damage in macrophages, whereas only beech and spruce log combustion samples caused DNA damage in epithelial cells. The organic content of the samples was mainly associated with cytotoxicity and DNA damage, while the metal content of the samples correlated with the induction of inflammatory responses. All of the tested PM samples induce adverse effects and the chemical composition of the samples determines which pathway of toxicity is induced. In vitro testing of the toxicity of combustion-derived PM in monocultures of one cell line, however, is inadequate to account for all the possible pathways of toxicity.

Differences between co-cultures and monocultures in testing the toxicity of particulate matter derived from log wood and pellet combustion

PubMed Central

Happo, Mikko S.; Rönkkö, Teemu J.; Orasche, Jürgen; Jokiniemi, Jorma; Kortelainen, Miika; Tissari, Jarkko; Zimmermann, Ralf; Hirvonen, Maija-Riitta; Jalava, Pasi I.

2018-01-01

Background In vitro studies with monocultures of human alveolar cells shed deeper knowledge on the cellular mechanisms by which particulate matter (PM) causes toxicity, but cannot account for mitigating or aggravating effects of cell-cell interactions on PM toxicity. Methods We assessed inflammation, oxidative stress as well as cytotoxic and genotoxic effects induced by PM from the combustion of different types of wood logs and softwood pellets in three cell culture setups: two monocultures of either human macrophage-like cells or human alveolar epithelial cells, and a co-culture of these two cell lines. The adverse effects of the PM samples were compared between these setups. Results We detected clear differences in the endpoints between the mono- and co-cultures. Inflammatory responses were more diverse in the macrophage monoculture and the co-culture compared to the epithelial cells where only an increase of IL-8 was detected. The production of reactive oxygen species was the highest in epithelial cells and macrophages seemed to have protective effects against oxidative stress from the PM samples. With no metabolically active cells at the highest doses, the cytotoxic effects of the PM samples from the wood log combustion were far more pronounced in the macrophages and the co-culture than in the epithelial cells. All samples caused DNA damage in macrophages, whereas only beech and spruce log combustion samples caused DNA damage in epithelial cells. The organic content of the samples was mainly associated with cytotoxicity and DNA damage, while the metal content of the samples correlated with the induction of inflammatory responses. Conclusions All of the tested PM samples induce adverse effects and the chemical composition of the samples determines which pathway of toxicity is induced. In vitro testing of the toxicity of combustion-derived PM in monocultures of one cell line, however, is inadequate to account for all the possible pathways of toxicity. PMID:29466392

PML-RARα kinetics and impact of FLT3-ITD mutations in newly diagnosed acute promyelocytic leukaemia treated with ATRA and ATO or ATRA and chemotherapy.

PubMed

Cicconi, L; Divona, M; Ciardi, C; Ottone, T; Ferrantini, A; Lavorgna, S; Alfonso, V; Paoloni, F; Piciocchi, A; Avvisati, G; Ferrara, F; Di Bona, E; Albano, F; Breccia, M; Cerqui, E; Sborgia, M; Kropp, M G; Santoro, A; Levis, A; Sica, S; Amadori, S; Voso, M T; Mandelli, F; Lo-Coco, F

2016-10-01

The APL0406 study showed that arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are not inferior to standard ATRA and chemotherapy (CHT) in newly diagnosed, low-intermediaterisk acute promyelocytic leukaemia (APL). We analysed the kinetics of promyelocytic leukaemia-retinoic acid receptor-α (PML-RARα) transcripts by real-time quantitative PCR (RQ-PCR) in bone marrow samples from 184 patients and assessed the prognostic impact of fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) in 159 patients enrolled in this trial in Italy. After induction therapy, the reduction of PML-RARα transcripts was significantly greater in patients receiving ATRA-CHT as compared with those treated with ATRA-ATO (3.4 vs 2.9 logs; P=0.0182). Conversely, at the end of consolidation, a greater log reduction of PML-RARα transcripts was detected in the ATRA-ATO as compared with the ATRA-CHT group (6.3 vs 5.3 logs; P=0.0024). FLT3-ITD mutations had no significant impact on either event-free survival (EFS) or cumulative incidence of relapse in patients receiving ATRA-ATO, whereas a trend for inferior EFS was observed in FLT3-ITD-positive patients receiving ATRA-CHT. Our study shows at the molecular level that ATRA-ATO exerts at least equal and probably superior antileukaemic efficacy compared with ATRA-CHT in low-intermediaterisk APL. The data also suggest that ATRA-ATO may abrogate the negative prognostic impact of FLT3-ITD.

Geophysical monitoring of a field-scale biostimulation pilot project

USGS Publications Warehouse

Lane, J.W.; Day-Lewis, F. D.; Casey, C.C.

2006-01-01

The USGS conducted a geophysical investigation in support of a U.S. Naval Facilities Engineering Command, Southern Division field-scale biostimulation pilot project at Anoka County Riverfront Park (ACP), downgradient of the Naval Industrial Reserve Ordnance Plant, Fridley, Minnesota. The goal of the pilot project is to evaluate subsurface injection of vegetable oil emulsion (VOE) to stimulate microbial degradation of chlorinated hydrocarbons. To monitor the emplacement and movement of the VOE and changes in water chemistry resulting from VOE dissolution and/or enhanced biological activity, the USGS acquired cross-hole radar zero-offset profiles, traveltime tomograms, and borehole geophysical logs during five site visits over 1.5 years. Analysis of pre- and postinjection data sets using petrophysical models developed to estimate VOE saturation and changes in total dissolved solids provides insights into the spatial and temporal distribution of VOE and ground water with altered chemistry. Radar slowness-difference tomograms and zero-offset slowness profiles indicate that the VOE remained close to the injection wells, whereas radar attenuation profiles and electromagnetic induction logs indicate that bulk electrical conductivity increased downgradient of the injection zone, diagnostic of changing water chemistry. Geophysical logs indicate that some screened intervals were located above or below zones of elevated dissolved solids; hence, the geophysical data provide a broader context for interpretation of water samples and evaluation of the biostimulation effort. Our results include (1) demonstration of field and data analysis methods for geophysical monitoring of VOE biostimulation and (2) site-specific insights into the spatial and temporal distributions of VOE at the ACP. ?? 2006 National Ground Water Association.

Geophysical monitoring of a field-scale biostimulation pilot project.

PubMed

Lane, John W; Day-Lewis, Frederick D; Casey, Clifton C

2006-01-01

The USGS conducted a geophysical investigation in support of a U.S. Naval Facilities Engineering Command, Southern Division field-scale biostimulation pilot project at Anoka County Riverfront Park (ACP), down-gradient of the Naval Industrial Reserve Ordnance Plant, Fridley, Minnesota. The goal of the pilot project is to evaluate subsurface injection of vegetable oil emulsion (VOE) to stimulate microbial degradation of chlorinated hydrocarbons. To monitor the emplacement and movement of the VOE and changes in water chemistry resulting from VOE dissolution and/or enhanced biological activity, the USGS acquired cross-hole radar zero-offset profiles, travel-time tomograms, and borehole geophysical logs during five site visits over 1.5 years. Analysis of pre- and postinjection data sets using petrophysical models developed to estimate VOE saturation and changes in total dissolved solids provides insights into the spatial and temporal distribution of VOE and ground water with altered chemistry. Radar slowness-difference tomograms and zero-offset slowness profiles indicate that the VOE remained close to the injection wells, whereas radar attenuation profiles and electromagnetic induction logs indicate that bulk electrical conductivity increased down-gradient of the injection zone, diagnostic of changing water chemistry. Geophysical logs indicate that some screened intervals were located above or below zones of elevated dissolved solids; hence, the geophysical data provide a broader context for interpretation of water samples and evaluation of the biostimulation effort. Our results include (1) demonstration of field and data analysis methods for geophysical monitoring of VOE biostimulation and (2) site-specific insights into the spatial and temporal distributions of VOE at the ACP.

Extension of structure-reactivity correlations for the hydrogen abstraction reaction by bromine atom and comparison to chlorine atom and hydroxyl radical

DOE PAGES

Poutsma, Marvin L.

2015-12-14

Recently we presented structure-reactivity correlations for the gas-phase ambient-temperature rate constants for hydrogen abstraction from sp 3-hybridized carbon by chlorine atom and hydroxyl radical (Cl•/HO• + HCR 3 → HCl/HOH + •CR 3); the reaction enthalpy effect was represented by the independent variable Δ rH and the polar effect by the independent variables F and R, the Hammett constants for field/inductive and resonance effects. Both these reactions are predominantly exothermic and have early transition states. Here we present a parallel treatment for Br• whose reaction is significantly endothermic with a correspondingly late transition state. In spite of lower expectations becausemore » the available data base is less extensive and much more scattered and because long temperature extrapolations are often required, the resulting least-squares fit (log k 298,Br = –0.147 Δ rH –4.32 ΣF –4.28 ΣR –12.38 with r 2 = 0.92) was modestly successful and useful for initial predictions. The coefficient of Δ rH was ~4-fold greater, indicative of the change from an early to a late transition state; meanwhile the sizable coefficients of ΣF and ΣR indicate the persistence of the polar effect. Although the mean unsigned deviation of 0.79 log k 298 units is rather large, it must be considered in the context of a total span of over 15 log units in the data set. Lastly, the major outliers are briefly discussed.« less

Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimen.

PubMed

Thirugnanam, Rajasekar; George, Biju; Chendamarai, Ezhil; Lakshmi, Kavitha M; Balasubramanian, Poonkuzhali; Viswabandya, Auro; Srivastava, Alok; Chandy, Mammen; Mathews, Vikram

2009-11-01

In patients with relapsed acute promyelocytic leukemia (APL), the best consolidation regimen following induction of remission with arsenic trioxide (ATO) remains to be defined. Since January 2000, 37 patients with relapsed APL were treated at our center. The median age was 34 years (range, 6-57 years), and there were 20 males (54.1%). The median duration of first remission was 20.3 months (range, 2.9-81.2 months). Relapse was treated with single-agent ATO in 22 patients (59.5%), ATO+ATRA in 5 patients (13.5%), and ATO+ATRA + anthracycline in 10 patients (27%). Thirty-three patients (89%) achieved molecular remission after induction and a consolidation course. Fourteen patients opted to undergo autologous stem cell transplantation (SCT), and the remaining 19 patients received monthly cycles of ATO as a single agent (n=13) or ATO+ATRA (n=6) for 6 months. At a median follow-up of 32 months, the 5-year Kaplan-Meier estimate of event-free survival (EFS) was 83.33% +/- 15.21% in those who underwent autologous SCT versus 34.45% +/- 11.24% in those who did not (P=.001; log-rank test). Following remission induction with ATO-based regimens in patients with relapsed APL, consolidation with autologous SCT is associated with a significantly superior clinical outcome compared with ATO- and ATO+ATRA-based maintenance regimens.

Well network installation and hydrogeologic data collection, Assateague Island National Seashore, Worcester County, Maryland, 2010

USGS Publications Warehouse

Banks, William S.L.; Masterson, John P.; Johnson, Carole D.

2012-01-01

The U.S. Geological Survey, as part of its Climate and Land Use Change Research and Development Program, is conducting a multi-year investigation to assess potential impacts on the natural resources of Assateague Island National Seashore, Maryland that may result from changes in the hydrologic system in response to projected sea-level rise. As part of this effort, 26 monitoring wells were installed in pairs along five east-west trending transects. Each of the five transects has between two and four pairs of wells, consisting of a shallow well and a deeper well. The shallow well typically was installed several feet below the water table—usually in freshwater about 10 feet below land surface (ft bls)—to measure water-level changes in the shallow groundwater system. The deeper well was installed below the anticipated depth to the freshwater-saltwater interface—usually in saltwater about 45 to 55 ft bls—for the purpose of borehole geophysical logging to characterize local differences in lithology and salinity and to monitor tidal influences on groundwater. Four of the 13 shallow wells and 5 of the 13 deeper wells were instrumented with water-level recorders that collected water-level data at 15-minute intervals from August 12 through September 28, 2010. Data collected from these instrumented wells were compared with tide data collected north of Assateague Island at the Ocean City Inlet tide gage, and precipitation data collected by National Park Service staff on Assateague Island. These data indicate that precipitation events coupled with changes in ambient sea level had the largest effect on groundwater levels in all monitoring wells near the Atlantic Ocean and Chincoteague and Sinepuxent Bays, whereas precipitation events alone had the greatest impact on shallow groundwater levels near the center of the island. Daily and bi-monthly tidal cycles appeared to have minimal influence on groundwater levels throughout the island and the water-level changes that were observed appeared to vary among well sites, indicating that changes in lithology and salinity also may affect the response of water levels in the shallow and deeper groundwater systems throughout the island. Borehole geophysical logs were collected at each of the 13 deeper wells along the 5 transects. Electromagnetic induction logs were collected to identify changes in lithology; determine the approximate location of the freshwater-saltwater interface; and characterize the distribution of fresh and brackish water in the shallow aquifer, and the geometry of the fresh groundwater lens beneath the island. Natural gamma logs were collected to provide information on the geologic framework of the island including the presence and thickness of finer-grained deposits found in the subsurface throughout the island during previous investigations. Results of this investigation show the need for collection of continuous water-level data in both the shallow and deeper parts of the flow system and electromagnetic induction and natural gamma geophysical logging data to better understand the response of this groundwater system to changes in precipitation and tidal forcing. Hydrologic data collected as part of this investigation will serve as the foundation for the development of numerical flow models to assess the potential effects of climate change on the coastal groundwater system of Assateague Island.

E2F3a gene expression has prognostic significance in childhood acute lymphoblastic leukemia.

PubMed

Wang, Kai-Ling; Mei, Yan-Yan; Cui, Lei; Zhao, Xiao-Xi; Li, Wei-Jing; Gao, Chao; Liu, Shu-Guang; Jiao, Ying; Liu, Fei-Fei; Wu, Min-Yuan; Ding, Wei; Li, Zhi-Gang

2014-10-01

To study E2F3a expression and its clinical significance in children with acute lymphoblastic leukemia (ALL). We quantified E2F3a expression at diagnosis in 148 children with ALL by real-time PCR. In the test cohort (n = 48), receiver operating characteristic (ROC) curve was used to find the best cut-off point to divide the patients into E2F3a low- and high-expression groups. The prognostic significance of E2F3a expression was investigated in the test cohort and confirmed in the validation cohort (n = 100). The correlations of E2F3a expression with the clinical features and treatment outcome of these patients were analyzed. ROC curve analysis indicated that the best cut-off point of E2F3a expression was 0.3780. In the test cohort, leukemia-free survival (LFS) and event-free survival (EFS) of the low-expression group were lower than those of the high-expression group (log rank: P = 0.026 for both). This finding was verified in the validation cohort. LFS, EFS, and overall survival were also lower in the low-expression group than in the high-expression group (log rank, P = 0.015, 0.008, and 0.002 respectively). E2F3a low expression was correlated with the existence of BCR-ABL fusion. An algorithm composed of E2F3a expression and minimal residual disease (MRD) could predict relapse or induction failure more precisely than current risk stratification. These results were still significant in the ALL patients without BCR-ABL fusion. Low expression of E2F3a was associated with inferior prognosis in childhood ALL. An algorithm composed of E2F3a expression and MRD could predict relapse or induction failure more precisely than that of the current risk stratification. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.

PubMed

Viprey, Virginie F; Gregory, Walter M; Corrias, Maria V; Tchirkov, Andrei; Swerts, Katrien; Vicha, Ales; Dallorso, Sandro; Brock, Penelope; Luksch, Roberto; Valteau-Couanet, Dominique; Papadakis, Vassilios; Laureys, Genevieve; Pearson, Andrew D; Ladenstein, Ruth; Burchill, Susan A

2014-04-01

To evaluate the hypothesis that detection of neuroblastoma mRNAs by reverse transcriptase quantitative polymerase chain reaction (RTqPCR) in peripheral blood (PB) and bone marrow aspirates (BM) from children with stage 4 neuroblastoma are clinically useful biomarkers of risk. RTqPCR for paired-like homeobox 2b (PHOX2B), tyrosine hydroxylase (TH), and doublecortin (DCX) mRNA in PB and BM of children enrolled onto the High-Risk Neuroblastoma Trial-1 of the European Society of Pediatric Oncology Neuroblastoma Group (HR-NBL1/SIOPEN) was performed at diagnosis and after induction therapy. High levels of TH, PHOX2B, or DCX mRNA in PB or BM at diagnosis strongly predicted for worse event-free survival (EFS) and overall survival (OS) in a cohort of 290 children. After induction therapy, high levels of these mRNAs predicted worse EFS and OS in BM but not in PB. Combinations of mRNAs in BM did not add to the predictive power of any single mRNA. However, in the original (n = 182) and validation (n = 137) PB cohorts, high TH (log10TH > 0.8) or high PHOX2B (log10PHOX2B > 0.28) identify 19% of children as ultrahigh risk, with 5-year EFS and OS rates of 0%; OS rate was 25% (95% CI, 16% to 36%) and EFS rate was 38% (95% CI, 28% to 49%) in the remaining children. The magnitude of reduction in mRNA level between diagnosis and postinduction therapy in BM or PB was not of additional predictive value. High levels of TH and PHOX2B mRNA in PB at diagnosis objectively identify children with ultrahigh-risk disease who may benefit from novel treatment approaches. The level of TH, PHOX2B, and DCX mRNA in BM and/or PB at diagnosis might contribute to an algorithm to improve stratification of children for treatment.

Quantitative analysis of gold nanoparticles in single cells by laser ablation inductively coupled plasma-mass spectrometry.

PubMed

Wang, Meng; Zheng, Ling-Na; Wang, Bing; Chen, Han-Qing; Zhao, Yu-Liang; Chai, Zhi-Fang; Reid, Helen J; Sharp, Barry L; Feng, Wei-Yue

2014-10-21

Single cell analysis has become an important field of research in recent years reflecting the heterogeneity of cellular responses in biological systems. Here, we demonstrate a new method, based on laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), which can quantify in situ gold nanoparticles (Au NPs) in single cells. Dried residues of picoliter droplets ejected by a commercial inkjet printer were used to simulate matrix-matched calibration standards. The gold mass in single cells exposed to 100 nM NIST Au NPs (Reference material 8012, 30 nm) for 4 h showed a log-normal distribution, ranging from 1.7 to 72 fg Au per cell, which approximately corresponds to 9 to 370 Au NPs per cell. The average result from 70 single cells (15 ± 13 fg Au per cell) was in good agreement with the result from an aqua regia digest solution of 1.2 × 10(6) cells (18 ± 1 fg Au per cell). The limit of quantification was 1.7 fg Au. This paper demonstrates the great potential of LA-ICPMS for single cell analysis and the beneficial study of biological responses to metal drugs or NPs at the single cell level.

A high-temperature furnace for in situ synchrotron X-ray spectroscopy under controlled atmospheric conditions.

PubMed

Eeckhout, Sigrid Griet; Gorges, Bernard; Barthe, Laurent; Pelosi, Orietta; Safonova, Olga; Giuli, Gabriele

2008-09-01

A high-temperature furnace with an induction heater coil has been designed and constructed for in situ X-ray spectroscopic experiments under controlled atmospheric conditions and temperatures up to 3275 K. The multi-purpose chamber design allows working in backscattering and normal fluorescence mode for synchrotron X-ray absorption and emission spectroscopy. The use of the furnace is demonstrated in a study of the in situ formation of Cr oxide between 1823 K and 2023 K at logPO(2) values between -10.0 and -11.3 using X-ray absorption near-edge spectroscopy. The set-up is of particular interest for studying liquid metals, alloys and other electrically conductive materials under extreme conditions.

Geohydrologic and water-quality data in the vicinity of the Rialto-Colton Fault, San Bernardino, California

USGS Publications Warehouse

Teague, Nicholas F.; Brown, Anthony A.; Woolfenden, Linda R.

2014-01-01

The Rialto-Colton Basin is in western San Bernardino County, about 60 miles east of Los Angeles, California. The basin is bounded by faults on the northeast and southwest sides and contains multiple barriers to groundwater flow. The structural geology of the basin leads to complex hydrology. Between 2001 and 2008, in an effort to better understand the complex hydrologic system of the Rialto-Colton Basin, seven multiple-well monitoring sites were constructed. Two to six observation wells were installed in the borehole at each site; a total of 32 observation wells were installed. This report presents geologic, hydrologic, and water-quality data collected from these seven multiple-well monitoring sites. Descriptions of the collected drill cuttings were compiled into lithologic logs for each monitoring site. The lithologic logs are summarized along with the geophysical logs, including gamma-ray, spontaneous potential, resistivity, and electromagnetic induction tool logs. At selected sites, sonic tool logs also were recorded. Periodic water-level measurements are reported, and water-level data are displayed on hydrographs. Water levels at multiple-well monitoring sites in the northern part of the study area differed between the shallow and deep observation wells; in the remaining multiple-well monitoring sites, water levels differed little with depth. Along the southern trace of the Rialto-Colton Fault, water levels are slightly higher east of the fault than west of the fault. Selected water-quality data for 21 of the observation wells show water from wells in the northern and central parts of the study area is calcium-carbonate water. In the southern part of the study area, water from wells screened above 400 feet below land surface is of mixed type or is calcium-carbonate water. Water from wells screened greater than 400 feet below land surface in the southern part of the study area is sodium-carbonate or sodium-mixed anion water. Water from most wells in the study area plots above the Global Meteoric Water Line along an apparent local meteoric water line, indicating the water has not experienced substantial evaporation before infiltration. A few samples from shallow wells in the study area plot slightly to the right of the Global Meteoric Water Line, possibly indicating the water experienced some evaporation before recharge.

Retrospective study of various conservative treatment options with bacille Calmette-Guérin in bladder urothelial carcinoma T1G3: Maintenance therapy.

PubMed

Palou-Redorta, J; Solsona, E; Angulo, J; Fernández, J M; Madero, R; Unda, M; Martínez-Piñeiro, J A; Portillo, J; Chantada, V; Moyano, J L

2016-01-01

To compare various conservative treatment options for high-grade T1 nonmuscle-invasive bladder cancer (NMIBC). Bacille Calmette-Guérin (BCG) is the preferred intravesical treatment for high-grade T1 tumours; however, a number of experts still question the need for maintenance BCG. We retrospectively analysed data from 1039 patients with primary and recurrent T1G3 NMIBC. All patients underwent complete transurethral resection of the bladder tumour (TURBT), with muscle in the sample and multiple bladder biopsies. The patients were treated with the following: only one initial TURBT (n=108), re-TURBT (n=153), induction with 27mg of BCG (Connaught strain) (n=87), induction with 81mg of BCG (n=489) or induction with 81mg of BCG+maintenance (n=202). The time to first recurrence, progression (to T2 or greater or to metastatic disease) and specific mortality of the disease was assessed using the Kaplan-Meier survival function and were compared using the log-rank test and the Cox multivariate regression model of proportional risks. The mean follow-up was 62±39 months. The risk of recurrence was significantly lower for the patients treated with maintenance therapy of 81mg of BCG than in the other treatment groups (P<.001). The risk of tumour progression was also significantly lower for the patients treated with maintenance BCG than for the patients treated only with one TURBT, re-TURBT and with induction therapy with 27mg of BCG (P=.0003). The specific disease mortality was significantly lower with BCG maintenance (9.4%) than with only one TURBT (27.8%; P=.003). In the case of T1G3 NMIBC, a complete dose of BCG with maintenance is associated with better recurrence results than are other conservative treatment modalities. The results of progression and survival specific to the disease were also better with induction BCG, with or without maintenance. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

Preinduction incentive spirometry versus deep breathing to improve apnea tolerance during induction of anesthesia in patients of abdominal sepsis: A randomized trial.

PubMed

Tripathi, M; Subedi, A; Raimajhi, A; Pokharel, K; Pandey, M

2013-01-01

Abdominal sepsis is associated with varied degree of hypoxemia and atelactasis in the lung and can enhance the onset of desaturation of arterial blood during apnea. This study looked at methods to improve safety margin of apnea during induction of anesthesia in these high-risk patients. It was a randomized, single blind study on adult patients presenting for emergency laparotomy due to peritonitis in a university teaching hospital setting. In group 1 (IS) (n = 32), three sessions of incentive spirometry (IS) were performed within one hour before induction of anesthesia. In group 2 (DB) (n = 34), patients were subjected to deep breathing sessions in a similar manner. All patients received preoxygenation (100%) by mask for 3 min, followed by rapid-sequence induction of anesthesia using fentanyl, thiopental, and suxamethonium and endotracheal intubation. Patients were subjected to a period of apnea by keeping the end of the endotracheal tube open to air till they developed 95% hemoglobin saturation (SpO 2) by pulse oxymetry. Positive pressure ventilation was resumed at the end. We observed for hemodynamic changes, apnea time, and SpO 2 (100%) recovery time on resuming ventilation. Arterial blood gas samples were taken before intervention, after IS or DB, after preoxygenation, and at the end of apnea. One-way analysis of variance (ANOVA), X 2 test, Kaplan-Meier graph, and log-rank tests were applied to compare the two study groups. Oxygenation level in group 1 (265 ± 76.7 mmHg) patients was significantly (P < 0.001) higher than in group 2 (221 ± 61.8 mmHg)at the end of preoxygenation. The apnea time (median: lower bound - upper bound Confidence Interval apnea time) (272:240-279 s) in group 1 (IS) patients was significantly higher P < 0.05) than in group 2 (180:163-209 s) patients. Saturation recovery time (35:34-46 s) in group 1 (IS) patients was also quicker than in group 2 patients (48:44-58 s). IS in the preoperative period is superior to deep breathing sessions for improving apnea tolerance during induction of anesthesia in abdominal sepsis patients.

Structured scaffolding for reflection and problem solving in diabetes self-management: qualitative study of mobile diabetes detective.

PubMed

Mamykina, Lena; Heitkemper, Elizabeth M; Smaldone, Arlene M; Kukafka, Rita; Cole-Lewis, Heather; Davidson, Patricia G; Mynatt, Elizabeth D; Tobin, Jonathan N; Cassells, Andrea; Goodman, Carrie; Hripcsak, George

2016-01-01

To investigate subjective experiences and patterns of engagement with a novel electronic tool for facilitating reflection and problem solving for individuals with type 2 diabetes, Mobile Diabetes Detective (MoDD). In this qualitative study, researchers conducted semi-structured interviews with individuals from economically disadvantaged communities and ethnic minorities who are participating in a randomized controlled trial of MoDD. The transcripts of the interviews were analyzed using inductive thematic analysis; usage logs were analyzed to determine how actively the study participants used MoDD. Fifteen participants in the MoDD randomized controlled trial were recruited for the qualitative interviews. Usage log analysis showed that, on average, during the 4 weeks of the study, the study participants logged into MoDD twice per week, reported 120 blood glucose readings, and set two behavioral goals. The qualitative interviews suggested that individuals used MoDD to follow the steps of the problem-solving process, from identifying problematic blood glucose patterns, to exploring behavioral triggers contributing to these patterns, to selecting alternative behaviors, to implementing these behaviors while monitoring for improvements in glycemic control. This qualitative study suggested that informatics interventions for reflection and problem solving can provide structured scaffolding for facilitating these processes by guiding users through the different steps of the problem-solving process and by providing them with context-sensitive evidence and practice-based knowledge related to diabetes self-management on each of those steps. This qualitative study suggested that MoDD was perceived as a useful tool in engaging individuals in self-monitoring, reflection, and problem solving. © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Acoustic paramagnetic logging tool

DOEpatents

Vail, III, William B.

1988-01-01

New methods and apparatus are disclosed which allow measurement of the presence of oil and water in geological formations using a new physical effect called the Acoustic Paramagnetic Logging Effect (APLE). The presence of petroleum in formation causes a slight increase in the earth's magnetic field in the vicinity of the reservoir. This is the phenomena of paramagnetism. Application of an acoustic source to a geological formation at the Larmor frequency of the nucleons present causes the paramagnetism of the formation to disappear. This results in a decrease in the earth3 s magnetic field in the vicinity of the oil bearing formation. Repetitively frequency sweeping the acoustic source through the Larmor frequency of the nucleons present (approx. 2 kHz) causes an amplitude modulation of the earth's magnetic field which is a consequence of the APLE. The amplitude modulation of the earth's magnetic field is measured with an induction coil gradiometer and provides a direct measure of the amount of oil and water in the excitation zone of the formation . The phase of the signal is used to infer the longitudinal relaxation times of the fluids present, which results in the ability in general to separate oil and water and to measure the viscosity of the oil present. Such measurements may be preformed in open boreholes and in cased well bores.

Results of time-domain electromagnetic soundings in Miami-Dade and southern Broward Counties, Florida

USGS Publications Warehouse

Fitterman, David V.; Prinos, Scott T.

2011-01-01

Time-domain electromagnetic (TEM) soundings were made in Miami-Dade and southern Broward Counties to aid in mapping the landward extent of saltwater in the Biscayne aquifer. A total of 79 soundings were collected in settings ranging from urban to undeveloped land, with some of the former posing problems of land access and interference from anthropogenic features. TEM soundings combined with monitoring-well data were used to determine if the saltwater front had moved since the last time it was mapped, to provide additional spatial coverage where existing monitoring wells were insufficient, and to help interpret a previously collected helicopter electromagnetic (HEM) survey flown in the southernmost portion of the study area. TEM soundings were interpreted as layered resistivity-depth models. Using information from well logs and water-quality data, the resistivity of the freshwater saturated Biscayne aquifer is expected to be above 30 ohm-meters, and the saltwater-saturated aquifer will have resistivities of less than 10 ohm-meters allowing determination of water quality from the TEM interpretations. TEM models from 29 soundings were compared to electromagnetic induction logs collected in nearby monitoring wells. In general, the agreement of these results was very good, giving confidence in the use of the TEM data for mapping saltwater encroachment.

Mass Median Plume Angle: A novel approach to characterize plume geometry in solution based pMDIs.

PubMed

Moraga-Espinoza, Daniel; Eshaghian, Eli; Smyth, Hugh D C

2018-05-30

High-speed laser imaging (HSLI) is the preferred technique to characterize the geometry of the plume in pressurized metered dose inhalers (pMDIs). However, current methods do not allow for simulation of inhalation airflow and do not use drug mass quantification to determine plume angles. To address these limitations, a Plume Induction Port Evaluator (PIPE) was designed to characterize the plume geometry based on mass deposition patterns. The method is easily adaptable to current pMDI characterization methodologies, uses similar calculations methods, and can be used under airflow. The effect of airflow and formulation on the plume geometry were evaluated using PIPE and HSLI. Deposition patterns in PIPE were highly reproducible and log-normal distributed. Mass Median Plume Angle (MMPA) was a new characterization parameter to describe the effective angle of the droplets deposited in the induction port. Plume angles determined by mass showed a significant decrease in size as ethanol increases which correlates to the decrease on vapor pressure in the formulation. Additionally, airflow significantly decreased the angle of the plumes when cascade impactor was operated under flow. PIPE is an alternative to laser-based characterization methods to evaluate the plume angle of pMDIs based on reliable drug quantification while simulating patient inhalation. Copyright © 2018. Published by Elsevier B.V.

Nitrogen Gas Plasma Generated by a Static Induction Thyristor as a Pulsed Power Supply Inactivates Adenovirus

PubMed Central

Sakudo, Akikazu; Toyokawa, Yoichi; Imanishi, Yuichiro

2016-01-01

Adenovirus is one of the most important causative agents of iatrogenic infections derived from contaminated medical devices or finger contact. In this study, we investigated whether nitrogen gas plasma, generated by applying a short high-voltage pulse to nitrogen using a static induction thyristor power supply (1.5 kilo pulse per second), exhibited a virucidal effect against adenoviruses. Viral titer was reduced by one log within 0.94 min. Results from detection of viral capsid proteins, hexon and penton, by Western blotting and immunochromatography were unaffected by the plasma treatment. In contrast, analysis using the polymerase chain reaction suggested that plasma treatment damages the viral genomic DNA. Reactive chemical products (hydrogen peroxide, nitrate, and nitrite), ultraviolet light (UV-A) and slight temperature elevations were observed during the operation of the gas plasma device. Viral titer versus intensity of each potential virucidal factor were used to identify the primary mechanism of disinfection of adenovirus. Although exposure to equivalent levels of UV-A or heat treatment did not inactivate adenovirus, treatment with a relatively low concentration of hydrogen peroxide efficiently inactivated the virus. Our results suggest the nitrogen gas plasma generates reactive chemical products that inactivate adenovirus by damaging the viral genomic DNA. PMID:27322066

Factors determining the smooth flow and the non-operative time in a one-induction room to one-operating room setting

PubMed Central

Mulier, Jan P; De Boeck, Liesje; Meulders, Michel; Beliën, Jeroen; Colpaert, Jan; Sels, Annabel

2015-01-01

Rationale, aims and objectives What factors determine the use of an anaesthesia preparation room and shorten non-operative time? Methods A logistic regression is applied to 18 751 surgery records from AZ Sint-Jan Brugge AV, Belgium, where each operating room has its own anaesthesia preparation room. Surgeries, in which the patient's induction has already started when the preceding patient's surgery has ended, belong to a first group where the preparation room is used as an induction room. Surgeries not fulfilling this property belong to a second group. A logistic regression model tries to predict the probability that a surgery will be classified into a specific group. Non-operative time is calculated as the time between end of the previous surgery and incision of the next surgery. A log-linear regression of this non-operative time is performed. Results It was found that switches in surgeons, being a non-elective surgery as well as the previous surgery being non-elective, increase the probability of being classified into the second group. Only a few surgery types, anaesthesiologists and operating rooms can be found exclusively in one of the two groups. Analysis of variance demonstrates that the first group has significantly lower non-operative times. Switches in surgeons, anaesthesiologists and longer scheduled durations of the previous surgery increases the non-operative time. A switch in both surgeon and anaesthesiologist strengthens this negative effect. Only a few operating rooms and surgery types influence the non-operative time. Conclusion The use of the anaesthesia preparation room shortens the non-operative time and is determined by several human and structural factors. PMID:25496600

Autologous stem cell transplantation in first complete remission may not extend progression-free survival in patients with peripheral T cell lymphomas.

PubMed

Yam, Clinton; Landsburg, Daniel J; Nead, Kevin T; Lin, Xinyi; Mato, Anthony R; Svoboda, Jakub; Loren, Alison W; Frey, Noelle V; Stadtmauer, Edward A; Porter, David L; Schuster, Stephen J; Nasta, Sunita D

2016-07-01

Patients with peripheral T cell lymphomas (PTCL) generally have a poor prognosis when treated with conventional chemotherapy. Consolidation with autologous stem cell transplantation (ASCT) has been reported to improve progression-free survival. However, these studies have not compared consolidative ASCT with active observation in patients with PTCL achieving first complete remission (CR1) following induction chemotherapy. We conducted a retrospective analysis of PTCL patients treated at the University of Pennsylvania between 1/1/2007 and 12/31/2014. Patients with cutaneous T cell lymphoma, concurrent B cell lymphomas, and anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK-positive ALCL) were excluded from the study. We compared progression-free survival for patients who underwent ASCT in CR1 following CHOP-like induction regimens and patients who underwent active observation during CR1. 48 patients met all inclusion and exclusion criteria and underwent either active observation (28 patients) or consolidative ASCT (20 patients) in CR1. The 1-year cumulative incidence of relapse in the observation and ASCT groups was 50% (95% confidence interval [CI]: 30-67%) and 46% (95% CI: 23-67%), respectively (P = 0.55). Median progression-free survival in the observation and ASCT groups was 15.8 and 12.8 months, respectively (log rank, P = 0.79). Estimated 3-year progression-free survival in the observation and ASCT groups was 37 and 41%, respectively. In conclusion, for PTCL patients achieving CR1 following CHOP-like induction chemotherapy, ASCT does not appear to improve progression-free survival compared to active observation. This finding should be confirmed in a larger, prospective study. Am. J. Hematol. 91:672-676, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis.

PubMed

Morgan, Gareth J; Gregory, Walter M; Davies, Faith E; Bell, Sue E; Szubert, Alexander J; Brown, Julia M; Coy, Nuria N; Cook, Gordon; Russell, Nigel H; Rudin, Claudius; Roddie, Huw; Drayson, Mark T; Owen, Roger G; Ross, Fiona M; Jackson, Graham H; Child, J Anthony

2012-01-05

Thalidomide maintenance has the potential to modulate residual multiple myeloma (MM) after an initial response. This trial compared the effect of thalidomide maintenance and no maintenance on progression-free survival (PFS) and overall survival (OS) in MM patients. After intensive or nonintensive induction therapy, 820 newly diagnosed MM patients were randomized to open-label thalidomide maintenance until progression, or no maintenance. Interphase FISH (iFISH) analysis was performed at study entry. Median PFS was significantly longer with thalidomide maintenance (log-rank P < .001). Median OS was similar between regimens (log-rank P = .40). Patients with favorable iFISH showed improved PFS (P = .004) and a trend toward a late survival benefit. Patients with adverse iFISH receiving thalidomide showed no significant PFS benefit and worse OS (P = .009). Effective relapse therapy enhanced survival after progression, translating into a significant OS benefit. Meta-analysis of this and other studies show a significant late OS benefit (P < .001, 7-year difference hazard ratio = 12.3; 95% confidence interval, 5.5-19.0). Thalidomide maintenance significantly improves PFS and can be associated with improved OS. iFISH testing is important in assessing the clinical impact of maintenance therapy. Overview analysis demonstrated that thalidomide maintenance was associated with a significant late OS benefit. This trial was registered at www.isrctn.org as #ISRCTN68454111.

Multifactorial analysis of renal transplants reported to the United Network for Organ Sharing Registry: a 1994 update.

PubMed

Gjertson, D W

1994-01-01

1. From a multivariate log-linear analysis of 57,303 renal transplants between 1988 and 1994, the top 10 factors influencing one-year and 3-year cadaveric graft survival rates were ranked as follows: [table: see text] 2. Center effects accounted for 30% and 28% of all assignable variations in one-year and 3-year outcomes, respectively. Although center variation dominated 32 other variables, most factors were relatively independent of transplant center. 3. Novel to our own multifactorial analyses of the UNOS Kidney Transplant Registry were 6 pretransplant factors (recipient pretransplant dialysis, pregnancy, PRA technique, donor disposition and preservation, and ABO compatibility). Survival rates over the various combinations of these new factors were not significantly different. 4. For the first time in our multivariate analyses, 4 posttransplantation factors (delayed graft function, rejection episodes prior to discharge, induction and maintenance drug therapies) were included in the log-linear model. It is noteworthy that graft survival in both transplant periods was seriously imperiled following delayed graft function or rejection prior to discharge, yet the accounting for these pseudo-outcome variables did not alter the influence of the remaining 31 transplant factors. Finally, maintenance drug therapies strongly influenced short-term outcomes but did not influence long-term results, except for a noteworthy trend toward increased survival rates for FK506 therapy.

Analysis of the Bacterial Heat Shock Response to Photodynamic Therapy-Mediated Oxidative Stress

PubMed Central

St. Denis, Tyler G.; Huang, Liyi; Dai, Tianhong; Hamblin, Michael R.

2011-01-01

Antimicrobial photodynamic therapy (PDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms. We investigated whether PDT induced protective responses such as heat shock proteins in bacteria. Using the photosensitizer Toluidine Blue O (TBO) at sub-lethal PDT conditions, a 7-fold increase in bacterial heat shock protein GroEL and a 3-fold increase in heat shock protein DnaK were observed in Escherichia coli post PDT. Pretreatment with 50o C heat for 30 minutes reduced PDT killing in both E. coli and in Enterococcus faecalis, with the most pronounced inhibition occurring at 50-μM TBO with 5-J/cm2 635 nm light, where E. coli killing was reduced by 2- log10 and E. faecalis killing was reduced by 4-log10. Finally, inhibition of the highly conserved chaperone DnaK using a small molecule benzylidene lactam heat shock protein inhibitor potentiated (but not significantly) the effect of PDT at a TBO concentration of 2.5 μM in E. faecalis; however, this effect was not observed in E. coli presumably because inhibitor could not gain access due to Gram-negative permeability barrier. Induction of heat shock proteins may be a mechanism whereby bacteria could become resistant to PDT and warrants the need for further study in the application of dual PDT-heat shock protein-inhibition therapies. PMID:21261628

Aryl hydrocarbon receptor-mediated toxic potency of dissolved lipophilic organic contaminants collected from Lincoln Creek, Milwaukee, Wisconsin, USA, to PLHC-1 (Poeciliopsis lucida) fish hepatoma cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Villeneuve, D.L.; Crunkilton, R.L.; DeVita, W.M.

1997-05-01

Lincoln Creek is a severely degraded urban stream located in Milwaukee County, Wisconsin, USA. As part of a comprehensive study on effects of urban storm water runoff on the stream biota, an in vitro bioassay with PLHC-1 (Poeciliopsis lucida) fish hepatoma cells was used to assess potential toxic potency of aryl hydrocarbon receptor (AhR)-active compounds, collected by semipermeable membrane devices (SPMDs) exposed to Lincoln Creek water. Dialysates from SPMDs exposed to Lincoln Creek water caused marked cytochrome P4501A induction in PLHC-1. Toxic potency of dialysates, expressed as bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQ) ranged from 1,300 to 6,600 pg TCDD-EQ/g SPMD formore » 14-d exposures. Dialysates from SPMDs exposed to stream water at base flow had potencies consistently lower than those exposed to storm-flow (high-flow) events that occurred during the same 14-d period. Polychlorinated biphenyls were not detectable in the dialysates. Gas chromatography-mass spectrometry analysis identified polycyclic aromatic hydrocarbons (PAHs) as major contaminants in the dialysates. A log-log correlation of total PAHs and TCDD-EQ yielded an r{sup 2} of 0.802. Empirical evidence suggests that AhR-active PAHs can account for about 20 to 50% of the potency observed.« less

Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers.

PubMed

Modabbernia, A; Velthorst, E; Gennings, C; De Haan, L; Austin, C; Sutterland, A; Mollon, J; Frangou, S; Wright, R; Arora, M; Reichenberg, A

2016-08-01

Despite evidence for the effects of metals on neurodevelopment, the long-term effects on mental health remain unclear due to methodological limitations. Our objective was to determine the feasibility of studying metal exposure during critical neurodevelopmental periods and to explore the association between early-life metal exposure and adult schizophrenia. We analyzed childhood-shed teeth from nine individuals with schizophrenia and five healthy controls. We investigated the association between exposure to lead (Pb(2+)), manganese (Mn(2+)), cadmium (Cd(2+)), copper (Cu(2+)), magnesium (Mg(2+)), and zinc (Zn(2+)), and schizophrenia, psychotic experiences, and intelligence quotient (IQ). We reconstructed the dose and timing of early-life metal exposures using laser ablation inductively coupled plasma mass spectrometry. We found higher early-life Pb(2+) exposure among patients with schizophrenia than controls. The differences in log Mn(2+) and log Cu(2+) changed relatively linearly over time to postnatal negative values. There was a positive correlation between early-life Pb(2+) levels and psychotic experiences in adulthood. Moreover, we found a negative correlation between Pb(2+) levels and adult IQ. In our proof-of-concept study, using tooth-matrix biomarker that provides direct measurement of exposure in the fetus and newborn, we provide support for the role of metal exposure during critical neurodevelopmental periods in psychosis. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Evolution of structure-reactivity correlations for the hydrogen abstraction reaction by chlorine atom.

PubMed

Poutsma, Marvin L

2013-01-31

Empirical structure-reactivity correlations are developed for log k(298), the gas-phase rate constants for the reaction (Cl(•) + HCR(3) → ClH + CR(3)(•)). It has long been recognized that correlation with Δ(r)H is weak. The poor performance of the linear Evans-Polanyi formulation is illustrated and was little improved by adding a quadratic term, for example, by making its slope smoothly dependent on Δ(r)H [η ≡ (Δ(r)H - Δ(r)H(min))/(Δ(r)H(max) - Δ(r)H(min))]. The "polar effect" ((δ-)Cl---H---CR(3)(δ+))(++) has also been long discussed, but there is no formalization of this dependence based on widely available independent variable(s). Using the sum of Hammett constants for the R substituents also gave at best modest correlations, either for σ(para) or for its dissection into F (field/inductive) and R (resonance) effects. Much greater success was achieved by combining these approaches with the preferred independent variable set being either [(Δ(r)H)(2), Δ(r)H, ΣF, and ΣR] or [η, Δ(r)H, ΣF, and ΣR]. For 64 rate constants that span 7 orders of magnitude, these correlation formulations give r(2) > 0.87 and a mean unsigned deviation of <0.5 log k units, with even better performance if primary, secondary, and tertiary reaction centers are treated separately.

Associations between Diet and Toenail Arsenic Concentration among Pregnant Women in Bangladesh: A Prospective Study

PubMed Central

Lin, Pi-I. D.; Bromage, Sabri; Mostofa, Md. Golam; Allen, Joseph; Oken, Emily; Kile, Molly L.; Christiani, David C.

2017-01-01

This prospective study evaluated the relationship between long-term dietary habits and total arsenic (As) concentration in toenail clippings in a cohort of 1616 pregnant women in the Bangladeshi administrative regions of Sirajdikhan and Pabna Sadar. Diet was assessed at Gestation Week 28 and at Postpartum Month 1, using a locally-validated dish-based semi-quantitative food-frequency questionnaire. Toenail As concentration was analyzed by microwave-assisted acid digestion and inductively coupled plasma mass spectrometry. Associations between natural log-transformed consumption of individual food items and temporally matched natural log-transformed toenail As concentration were quantified using general linear models that accounted for As concentration in the primary drinking water source and other potential confounders. The analysis was stratified by As in drinking water (≤50 μg/L versus >50 μg/L) and the time of dietary assessment (Gestation Week 28 versus Postpartum Week 1). Interestingly, toenail As was not significantly associated with consumption of plain rice as hypothesized. However, toenail As was positively associated with consumption of several vegetable, fish and meat items and was negatively associated with consumption of rice, cereal, fruits, and milk based food items. Further studies in pregnant women are needed to compare As metabolism at different levels of As exposure and the interaction between dietary composition and As absorption. PMID:28441747

Improved Speed Control System for the 87,000 HP Wind Tunnel Drive

NASA Technical Reports Server (NTRS)

Becks, Edward A.; Bencic, Timothy J.; Blumenthal, Philip Z.

1995-01-01

This paper describes the design, installation, and integrated systems tests for a new drive motor speed control system which was part of a recent rehab project for the NASA Lewis 8x6 Supersonic Wind Tunnel. The tunnel drive consists of three mechanically-coupled 29,000 HP wound rotor induction motors driving an axial flow compressor. Liquid rheostats are used to vary the impedance of the rotor circuits, thus varying the speed of the drive system. The new design utilizes a distributed digital control system with a dual touch screen CRT operator console to provide alarm monitoring, logging, and trending. The liquid rheostats are driven by brushtype servomotor systems with magnetostrictive linear displacement transducers used for position feedback. The new system achieved all goals for speed variations with load, motor load balance, and control of total power.

Engineering parvovirus-like particles for the induction of B-cell, CD4(+) and CTL responses.

PubMed

Rueda, P; Martínez-Torrecuadrada, J L; Sarraseca, J; Sedlik, C; del Barrio, M; Hurtado, A; Leclerc, C; Casal, J I

1999-09-01

An antigen delivery system based on hybrid recombinant parvovirus-like particles (VLPs) formed by the self-assembly of the capsid VP2 protein of porcine (PPV) or canine parvovirus (CPV) expressed in insect cells with the baculovirus system has been developed. PPV:VLPs containing a CD8(+) epitope from the LCMV nucleoprotein evoked a potent CTL response and were able to protect mice against a lethal infection with the virus. Also, PPV:VLPs containing the C3:T epitope from poliovirus elicited a CD4(+)3 log(10) units) against poliovirus. The possibility of combining different types of epitopes in different positions of a single particle to stimulate different branches of the immune system paves the way to the production of more potent vaccines in a simple and cheap way.

Improved speed control system for the 87,000 HP wind tunnel drive

NASA Astrophysics Data System (ADS)

Becks, Edward A.; Bencic, Timothy J.; Blumenthal, Philip Z.

1995-01-01

This paper describes the design, installation, and integrated systems tests for a new drive motor speed control system which was part of a recent rehab project for the NASA Lewis 8x6 Supersonic Wind Tunnel. The tunnel drive consists of three mechanically-coupled 29,000 HP wound rotor induction motors driving an axial flow compressor. Liquid rheostats are used to vary the impedance of the rotor circuits, thus varying the speed of the drive system. The new design utilizes a distributed digital control system with a dual touch screen CRT operator console to provide alarm monitoring, logging, and trending. The liquid rheostats are driven by brushtype servomotor systems with magnetostrictive linear displacement transducers used for position feedback. The new system achieved all goals for speed variations with load, motor load balance, and control of total power.

Folate and Cobalamin Modify Associations between S-adenosylmethionine and Methylated Arsenic Metabolites in Arsenic-Exposed Bangladeshi Adults123

PubMed Central

Howe, Caitlin G.; Niedzwiecki, Megan M.; Hall, Megan N.; Liu, Xinhua; Ilievski, Vesna; Slavkovich, Vesna; Alam, Shafiul; Siddique, Abu B.; Graziano, Joseph H.; Gamble, Mary V.

2014-01-01

Chronic exposure to inorganic arsenic (InAs) through drinking water is a major problem worldwide. InAs undergoes hepatic methylation to form mono- and dimethyl arsenical species (MMA and DMA, respectively), facilitating arsenic elimination. Both reactions are catalyzed by arsenic (+3 oxidation state) methyltransferase (AS3MT) using S-adenosylmethionine (SAM) as the methyl donor, yielding the methylated product and S-adenosylhomocysteine (SAH), a potent product-inhibitor of AS3MT. SAM biosynthesis depends on folate- and cobalamin-dependent one-carbon metabolism. With the use of samples from 353 participants in the Folate and Oxidative Stress Study, our objective was to test the hypotheses that blood SAM and SAH concentrations are associated with arsenic methylation and that these associations differ by folate and cobalamin nutritional status. Blood SAM and SAH were measured by HPLC. Arsenic metabolites in blood and urine were measured by HPLC coupled to dynamic reaction cell inductively coupled plasma MS. In linear regression analyses, SAH was not associated with any of the arsenic metabolites. However, log(SAM) was negatively associated with log(% urinary InAs) (β: −0.11; 95% CI: −0.19, −0.02; P = 0.01), and folate and cobalamin nutritional status significantly modified associations between SAM and percentage of blood MMA (%bMMA) and percentage of blood DMA (%bDMA) (P = 0.02 and P = 0.01, respectively). In folate- and cobalamin-deficient individuals, log(SAM) was positively associated with %bMMA (β: 6.96; 95% CI: 1.86, 12.05; P < 0.01) and negatively associated with %bDMA (β: −6.19; 95% CI: −12.71, 0.32; P = 0.06). These findings suggest that when exposure to InAs is high, and methyl groups are limiting, SAM is used primarily for MMA synthesis rather than for DMA synthesis, contributing additional evidence that nutritional status may explain some of the interindividual differences in arsenic metabolism and, consequently, susceptibility to arsenic toxicity. PMID:24598884

The fate of verocytotoxigenic Escherichia coli C600φ3538(Δvtx2 ::cat) and its vtx2 prophage during grass silage preparation.

PubMed

Nyambe, S; Burgess, C; Whyte, P; O'Kiely, P; Bolton, D

2017-05-01

Silage is grass, preserved by fermentation and used as winter feed for cattle. The impact of a range of current grass silage preparation practices on the survival of Escherichia coli C600φ3538(Δvtx 2 ::cat) and on the induction, release and infectivity of free phage were investigated. Wilted and fresh grass samples, from plots with and without slurry application, were ensiled with or without formic acid. Each treatment combination was inoculated with approximately 6 log 10 CFU per g E. coli C600φ3538(Δvtx 2 ::cat) (donor strain) and E. coli C600::kanamycin R (recipient strain) in test-tube model silos and incubated in the dark at 15°C. The physico-chemical (pH, ammonia, ethanol, lactic acid and volatile fatty acids) and microbiological (total viable counts, TVC, total Enterobacteriaceae counts, TEC, E. coli counts, ECC and lactic acid bacteria, LAB) properties of each fermentation were monitored throughout the experiment as were the concentrations of E. coli C600φ3538(Δvtx 2 ::cat), E. coli C600::kanamycin R , free phage and transductants, using culture and PCR-based methods. Over the course of the experiment the pH of the grass samples typically decreased by 2 pH units. TVC, TEC and ECC decreased by up to 2·3, 6·4 and 6·2 log 10 CFU per g, respectively, while the LAB counts remained relatively stable at 5·2-7·1 log 10 CFU per g. Both donor and recipient strains decreased by approximately 5 log 10 CFU per g. Free phages were detected in all treatments and transductants were detected and confirmed by PCR in the silo containing wilted grass, pretreated with slurry and ensiled without formic acid. Verocytotoxigenic E. coli may survive the ensiling process and the conditions encountered are sufficient to induce vtx 2 bacteriophage leading to low levels of phage-mediated vtx 2 gene transfer. These studies suggest that the ensiling of grass may create an environment which facilitates the emergence of new verocytotoxigenic E. coli. © 2017 The Society for Applied Microbiology.

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Markley, Andrew L.; Begemann, Matthew B.; Clarke, Ryan E.

The application of synthetic biology requires characterized tools to precisely control gene expression. This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002. To address this gap, two orthogonal constitutive promoter libraries, one based on a cyanobacterial promoter and the other ported from Escherichia coli, were built and tested in PCC 7002. The libraries demonstrated 3 and 2.5 log dynamic ranges, respectively, but correlated poorly with E. coli expression levels. These promoter libraries were then combined to create and optimize a series of IPTG inducible cassettes. The resultant induction system hadmore » a 48-fold dynamic range and was shown to out-perform P trc constructs. Finally, a RBS library was designed and tested in PCC 7002. The presented synthetic biology toolbox will enable accelerated engineering of PCC 7002.« less

Synthetic Biology Toolbox for Controlling Gene Expression in the Cyanobacterium Synechococcus sp. strain PCC 7002

DOE PAGES

Markley, Andrew L.; Begemann, Matthew B.; Clarke, Ryan E.; ...

2014-09-12

The application of synthetic biology requires characterized tools to precisely control gene expression. This toolbox of genetic parts previously did not exist for the industrially promising cyanobacterium, Synechococcus sp. strain PCC 7002. To address this gap, two orthogonal constitutive promoter libraries, one based on a cyanobacterial promoter and the other ported from Escherichia coli, were built and tested in PCC 7002. The libraries demonstrated 3 and 2.5 log dynamic ranges, respectively, but correlated poorly with E. coli expression levels. These promoter libraries were then combined to create and optimize a series of IPTG inducible cassettes. The resultant induction system hadmore » a 48-fold dynamic range and was shown to out-perform P trc constructs. Finally, a RBS library was designed and tested in PCC 7002. The presented synthetic biology toolbox will enable accelerated engineering of PCC 7002.« less

Magnetostriction measurement by four probe method

NASA Astrophysics Data System (ADS)

Dange, S. N.; Radha, S.

2018-04-01

The present paper describes the design and setting up of an indigenouslydevelopedmagnetostriction(MS) measurement setup using four probe method atroom temperature.A standard strain gauge is pasted with a special glue on the sample and its change in resistance with applied magnetic field is measured using KeithleyNanovoltmeter and Current source. An electromagnet with field upto 1.2 tesla is used to source the magnetic field. The sample is placed between the magnet poles using self designed and developed wooden probe stand, capable of moving in three mutually perpendicular directions. The nanovoltmeter and current source are interfaced with PC using RS232 serial interface. A software has been developed in for logging and processing of data. Proper optimization of measurement has been done through software to reduce the noise due to thermal emf and electromagnetic induction. The data acquired for some standard magnetic samples are presented. The sensitivity of the setup is 1microstrain with an error in measurement upto 5%.

Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity

PubMed Central

Pichler, Verena; Heffeter, Petra; Valiahdi, Seied M.; Kowol, Christian R.; Egger, Alexander; Berger, Walter; Jakupec, Michael A.; Galanski, Markus; Keppler, Bernhard K.

2014-01-01

Eight novel mononuclear and two dinuclear platinum(IV) complexes were synthesized and characterized by elemental analysis, one- and two-dimensional NMR spectroscopy, mass spectrometry, and reversed-phase HPLC (log kw) and in one case by X-ray diffraction. Cytotoxicity of the compounds was studied in three human cancer cell lines (CH1, SW480, and A549) by means of the MTT assay, featuring IC50 values to the low micromolar range. Furthermore a selected set of compounds was investigated in additional cancer cell lines (P31 and P31/cis, A2780 and A2780/cis, SW1573, 2R120, and 2R160) with regard to their resistance patterns, offering a distinctly different scheme compared to cisplatin. To gain further insights into the mode of action, drug uptake, DNA synthesis inhibition, cell cycle effects, and induction of apoptosis were determined for two characteristic substances. PMID:23194425

Multi-stage microbial system for continuous hydrogen production

DOEpatents

Kosourov, Sergey; Ghirardi, Maria L.; Seibert, Michael

2010-06-08

A method of using sequential chemostat culture vessels to provide continuous H.sub.2 production, in which photosynthetic O.sub.2 evolution and H.sub.2 photoproduction are separated physically into two separate bioreactors, comprising: a) growing a microorganism culture able to continuously generate H.sub.2 by photosynthetically producing cells at about the early-to-late log state in a first photobioreactor operating as a sulfur chemostat under aerobic and/or conditions; b) continuously feeding cells from the first photobioreactor to a second photobioreactor operating under anaerobic conditions and sulfur deprivation conditions resulting from constant uptake of sulfate in the first bioreactor and a low rate of culture flow between the first and second bioreactors, for induction of hydrogenase and H.sub.2 photoproduction to allow for continuous cultivation of the microorganism's cells in the first photobioreactor and constant H.sub.2 production in the second photobioreactor, and c) H.sub.2 gas from the second photobioreactor.

Finite-element solution to multidimensional multisource electromagnetic problems in the frequency domain using non-conforming meshes

NASA Astrophysics Data System (ADS)

Soloveichik, Yury G.; Persova, Marina G.; Domnikov, Petr A.; Koshkina, Yulia I.; Vagin, Denis V.

2018-03-01

We propose an approach to solving multisource induction logging problems in multidimensional media. According to the type of induction logging tools, the measurements are performed in the frequency range of 10 kHz to 14 MHz, transmitter-receiver offsets vary in the range of 0.5-8 m or more, and the trajectory length is up to 1 km. For calculating the total field, the primary-secondary field approach is used. The secondary field is calculated with the use of the finite-element method (FEM), irregular non-conforming meshes with local refinements and a direct solver. The approach to constructing basis functions with the continuous tangential components (from Hcurl(Ω)) on the non-conforming meshes from the standard shape vector functions is developed. On the basis of this method, the algorithm of generating global matrices and a vector of the finite-element equation system is proposed. We also propose the method of grouping the logging tool positions, which makes it possible to significantly increase the computational effectiveness. This is achieved due to the compromise between the possibility of using the 1-D background medium, which is very similar to the investigated multidimensional medium for a small group, and the decrease in the number of the finite-element matrix factorizations with the increasing number of tool positions in one group. For calculating the primary field, we propose the method based on the use of FEM. This method is highly effective when the 1-D field is required to be calculated at a great number of points. The use of this method significantly increases the effectiveness of the primary-secondary field approach. The proposed approach makes it possible to perform modelling both in the 2.5-D case (i.e. without taking into account a borehole and/or invasion zone effect) and the 3-D case (i.e. for models with a borehole and invasion zone). The accuracy of numerical results obtained with the use of the proposed approach is compared with the one obtained by other codes for 1-D and 3-D anisotropic models. The results of this comparison lend support to the validity of our code. We also present the numerical results proving greater effectiveness of the finite-element approach proposed for calculating the 1-D field in comparison with the known codes implementing the semi-analytical methods for the case in which the field is calculated at a large number of points. Additionally, we present the numerical results which confirm the accuracy advantages of the automatic choice of a background medium for calculating the 1-D field as well as the results of 2.5-D modelling for a geoelectrical model with anisotropic layers, a fault and long tool-movement trajectory with the varying dip angle.

Subcritical crack growth in porcelains, glass-ceramics, and glass-infiltrated alumina composite for dental restorations.

PubMed

Gonzaga, Carla Castiglia; Yoshimura, Humberto Naoyuki; Cesar, Paulo Francisco; Miranda, Walter Gomes

2009-05-01

The objective was to compare fracture toughness (K(Ic)), stress corrosion susceptibility coefficient (n), and stress intensity factor threshold for crack propagation (K(I0)) of two porcelains [VM7/Vita (V) and d.Sign/Ivoclar (D)], two glass-ceramics [Empress/Ivolcar (E1) and Empress2/Ivlocar (E2)] and a glass-infiltrated alumina composite [In-Ceram Alumina/Vita (IC)]. Disks were constructed according to each manufacturer's processing method, and polished before induction of cracks by a Vickers indenter. Crack lengths were measured under optical microscopy at times between 0.1 and 100 h. Specimens were stored in artificial saliva at 37 degrees C during the whole experiment. K(Ic) and n were determined using indentation fracture method. K(I0) was determined by plotting log crack velocity versus log K(I). Microstructure characterization was carried out under SEM, EDS, X-ray diffraction and X-ray fluorescence. IC and E2 presented higher K(Ic) and K(I0) compared to E1, V, and D. IC presented the highest n value, followed by E2, D, E1, and V in a decreasing order. V and D presented similar K(Ic), but porcelain V showed higher K(I0) and lower n compared to D. Microstructure features (volume fraction, size, aspect ratio of crystalline phases and chemical composition of glassy matrix) determined K(Ic). The increase of K(Ic) value favored the increases of n and K(I0).

Thymic function, anti-thymocytes globulins, and cancer after renal transplantation.

PubMed

Ducloux, Didier; Bamoulid, Jamal; Courivaud, Cécile; Gaugler, Béatrice; Rebibou, Jean-Michel; Ferrand, Christophe; Chalopin, Jean-Marc; Borg, Christophe; Tiberghien, Pierre; Saas, Philippe

2011-07-01

Prolonged CD4 T cell lymphopenia after polyclonal antithymocyte globulins (ATG) is associated with an increased rate of cancers. Here, we examined whether pre-transplant thymic function estimated by TREC levels is predictive of cancer occurrence following ATG treatment. The impact of TREC on cancer occurrence was analyzed in 115 consecutive incident renal transplant recipients having received ATG. Mean follow-up was 7.5±2.6years. After ATG induction, patients with the lowest pre-transplant TREC values had lower post-transplant CD4(+) and CD4(+) CD45RA(+) CD45RO(-) T cell counts, and a higher frequency of T cells with a regulatory phenotype (CD127(+)CD4(+)CD25(+)Foxp3(+)). Log-transformed pre-transplant TREC values were significantly lower in patients who developed cancer after transplantation (p<0.0001). The cumulative incidence of cancer was higher in patients having the lowest pre-transplant TREC values (T1 [low]: 47.4%, T2 [medium]: 12.5%, and T3 [high]: 2.7%; p<0.0001). In multivariate analysis, pre-transplant TREC value was the only predictive factor of cancer (HR, 0.39; 95% CI, 0.16 to 0.97, for one log (TREC/10(6) PBMC); p=0.046). Pre-transplant thymic function is associated with an increased rate of post-transplant cancer in patients having received ATG. Omitting ATG in recipients with low pre-transplant TREC values should be considered. Copyright © 2011 Elsevier B.V. All rights reserved.

New insights into the ecological interaction between grape berry microorganisms and Drosophila flies during the development of sour rot.

PubMed

Barata, André; Santos, Sara Correia; Malfeito-Ferreira, Manuel; Loureiro, Virgílio

2012-08-01

In this work, we studied the ecological interactions between grape berry microorganisms and Drosophila sp. flies involved in sour rot disease during grape ripening. After veráison the total microbial counts of grape berries affected by sour rot increased from about 2 log CFU/g of berries to more than 7 log CFU/g. Berry damage provoked a clear shift in yeast diversity from basidiomycetes to ascomycetous fermentative species. The latter were mostly Pichia terricola, Hanseniaspora uvarum, Candida zemplinina, and Zygoascus hellenicus. However, these species were not able to produce the metabolites characteristic of sour rot (gluconic and acetic acids) in inoculated berries. On the contrary, the acetic acid bacteria Gluconacetobacter saccharivorans produced high levels of these acids, mainly when berries were incubated in the presence of the insect Drosophila sp. Sour rot was not observed when grape bunches were physically separated from insects, even when berries were artificially injured. The wounds made in berry skin healed in the absence of insects, thus preventing the development of sour rot. Therefore, in the vineyard, the induction of sour rot depends on the contamination of wounded berries by a microbial consortium--yeasts and acetic acid bacteria--transported by drosophilid insects which disseminate sour rot among damaged berries. In the absence of these insects, plant defense mechanisms are effective and lead to skin healing, preventing disease spread. Thus, we showed that Drosophila sp. act as a vector for microorganisms associated with grape sour rot disease.

The role of nailfold capillary dropout on mortality in systemic sclerosis.

PubMed

Tieu, Joanna; Hakendorf, Paul; Woodman, Richard J; Patterson, Karen; Walker, Jenny; Roberts-Thomson, Peter

2018-05-01

Semi-quantitative wide-field nailfold capillaroscopy (NFC) is a simple technique with proven utility in the early diagnosis of systemic sclerosis (SSc). Its role in prognosis, however, remains uncertain. To investigate the possible utility of NFC in predicting survival. Patients with SSc listed on the South Australian Scleroderma Register (SASR) with prior NFC performed at Flinders Medical Centre from 1991 to 2015 were included in this study. Baseline demographic data, diagnosis, scleroderma antibody status and mortality status were also collected for each patient. The cohort consisted of 99 patients with limited cutaneous SSc, 30 patients with diffuse cutaneous SSc and 23 with an overlap scleroderma syndrome. Fifty-six patients died during the period of study (censured end June 2015). Patients with diffuse scleroderma had significantly greater capillary dropout compared with limited and overlap scleroderma (P < 0.001). In univariate analysis, both capillary dropout scores (log-rank χ 2 = 8.75, P = 0.003) and antibody status (log-rank χ 2 = 13.94, P = 0.003) were associated with mortality. ANOVA showed a significant association between antibody status and capillary dropout (P < 0.001). In Cox regression, adjustment for capillary dropout attenuated the impact of autoantibody group on survival. Nailfold capillary dropout was significantly associated with mortality and the severity of dropout attenuates survival dictated by antibody status. Together these observations support the hypothesis that capillary dropout is on the causal pathway between induction of scleroderma associated autoantibodies and mortality. © 2018 Royal Australasian College of Physicians.

Applications of resistivity modeling in reservoir development: examples from Balder Field, Norwegian North Sea

USGS Publications Warehouse

Paillet, Frederick L.; Haynes, F.M.; Buretz, O.M.

2001-01-01

The massive Paleocene oil sands of the Balder Field are overlain by several thinly bedded Eocene sand-prone packages of variable facies and reservoir quality. Although these sands have been penetrated by numerous exploration and development wells, uncertainty remains as to their extent, distribution, and ultimate effect on reservoir performance. The section is geologically complex (thin beds, injected sands, shale clasts and laminae, and faulting), and also contains a field-wide primary gas cap. With a depletion plan involving both gas and water injection, geologic/reservoir characterization of the Eocene is critical for prudent resource management during depletion. With this goal, resistivity modeling and core-based thin bed reservoir description from the first phase of development drilling have been integrated with seismic attribute mapping. Detailed core description, core permeability and grain size distribution data delineate six facies and help in distinguishing laterally continuous massive and laminated sands from potentially non-connected injection sands and non-reservoir quality siltstones and tuffs. Volumetric assessment of the thin sand resource has been enhanced by I-D forward modeling of induction log response using a commercial resistivity modeling program, R,BAN. After defining beds and facies with core and high resolution log data, the AHF60 array induction curve response was approximated using the 6FF40 response. Because many of the beds were thinner than 6FF40 resolution, the modeling is considered to provide a lower bound on R,. However, for most beds this model-based R, is significantly higher than that provided by one-foot vertical resolution shallow resistivity data, and is thought to be the best available estimate of true formation resistivity. Sensitivities in STOOIP were assessed with multiple R, earth models which can later be tested against production results. In addition, water saturation height functions, developed in vertical wells and thick beds, can be validated in deviated wells with thin beds. Sand thickness models constrained by this logand core-based petrophysical analysis were used to build impedance seismic synthetic sections from which seismic attributes could be extracted and calibrated. The model-based attribute calibration was then applied to the seismic impedance 3-D cube permitting sand thickness to be mapped and reservoir geology to be modeled with significantly more detail than previously possible. These results will guide the field''s reservoir management and assist in the delineation of new targets.

Efficacy of an Abbreviated Induction Regimen of Amphotericin B Deoxycholate for Cryptococcal Meningoencephalitis: 3 Days of Therapy Is Equivalent to 14 Days

PubMed Central

Livermore, Joanne; Howard, Susan J.; Sharp, Andrew D.; Goodwin, Joanne; Gregson, Lea; Felton, Timothy; Schwartz, Julie A.; Walker, Catherine; Moser, Bill; Müller, Werner; Harrison, Thomas S.; Perfect, John R.; Hope, William W.

2014-01-01

ABSTRACT Cryptococcal meningoencephalitis is an urgent global health problem. Induction regimens using 14 days of amphotericin B deoxycholate (dAmB) are considered the standard of care but may not be suitable for resource-poor settings. We investigated the efficacy of conventional and abbreviated regimens of dAmB for cryptococcal meningoencephalitis in both murine and rabbit models of cryptococcal meningoencephalitis. We examined the extent to which immunological effectors contribute to the antifungal effect. We bridged the results to humans as a first critical step to define regimens suitable for further study in clinical trials. There were significant differences in the murine plasma-versus-cerebrum dAmB concentration-time profiles. dAmB was detectable in the cerebrum throughout the experimental period, even following the administration of only three doses of 3 mg/kg. dAmB induced a fungistatic effect in the cerebrum with a 2- to 3-log10 CFU/g reduction compared with controls. The effect of 3 days of therapy was the same as that of daily therapy for 14 days. There was no evidence of increased numbers of CD3+ CD4+ or CD3+ CD8+ cells in treated mice to account for the persistent antifungal effect of an abbreviated regimen. The administration of dAmB at 1 mg/kg/day for 3 days was the same as daily therapy in rabbits. The bridging studies suggested that a human regimen of 0.7 mg/kg/day for 3 days resulted in nearly maximal antifungal activity in both the cerebrum and cerebrospinal fluid. An abbreviated regimen (3 days of therapy) of dAmB appears to be just as effective as conventional induction therapy for cryptococcal meningoencephalitis. PMID:24473125

Acute lymphoblastic leukemia in children and adolescents: prognostic factors and analysis of survival

PubMed Central

Lustosa de Sousa, Daniel Willian; de Almeida Ferreira, Francisco Valdeci; Cavalcante Félix, Francisco Helder; de Oliveira Lopes, Marcos Vinicios

2015-01-01

Objective To describe the clinical and laboratory features of children and adolescents with acute lymphoblastic leukemia treated at three referral centers in Ceará and evaluate prognostic factors for survival, including age, gender, presenting white blood cell count, immunophenotype, DNA index and early response to treatment. Methods Seventy-six under 19-year-old patients with newly diagnosed acute lymphoblastic leukemia treated with the Grupo Brasileiro de Tratamento de Leucemia da Infância – acute lymphoblastic leukemia-93 and -99 protocols between September 2007 and December 2009 were analyzed. The diagnosis was based on cytological, immunophenotypic and cytogenetic criteria. Associations between variables, prognostic factors and response to treatment were analyzed using the chi-square test and Fisher's exact test. Overall and event-free survival were estimated by Kaplan–Meier analysis and compared using the log-rank test. A Cox proportional hazards model was used to identify independent prognostic factors. Results The average age at diagnosis was 6.3 ± 0.5 years and males were predominant (65%). The most frequently observed clinical features were hepatomegaly, splenomegaly and lymphadenopathy. Central nervous system involvement and mediastinal enlargement occurred in 6.6% and 11.8%, respectively. B-acute lymphoblastic leukemia was more common (89.5%) than T-acute lymphoblastic leukemia. A DNA index >1.16 was found in 19% of patients and was associated with favorable prognosis. On Day 8 of induction therapy, 95% of the patients had lymphoblast counts <1000/μL and white blood cell counts <5.0 × 109/L. The remission induction rate was 95%, the induction mortality rate was 2.6% and overall survival was 72%. Conclusion The prognostic factors identified are compatible with the literature. The 5-year overall and event-free survival rates were lower than those reported for developed countries. As shown by the multivariate analysis, age and baseline white blood cell count were independent prognostic factors. PMID:26190424

Spectral mechanisms of spatially induced blackness: data and quantitative model.

PubMed

Shinomori, K; Schefrin, B E; Werner, J S

1997-02-01

Spectral efficiency functions and tests of additivity were obtained with three observers to identify possible chromatic contributions to spatially induced blackness. Stimuli consisted of a series of monochromatic (400-700 nm; 10-nm steps), 52-arcmin circular test lights surrounded by broadband (x = 0.31, y = 0.37), 63-138-arcmin annuli of fixed retinal illuminance. The stimuli were imaged on the fovea in Maxwellian view as 500-ms flashes with 10-s interstimulus intervals. Observers decreased the intensity of the test center until it was first perceived as completely black. Action spectra determined for two surround levels [2.5 and 3.5 log trolands] had three sensitivity peaks (at approximately 440, 540, and 600 nm), However, when monochromatic surrounds were adjusted to induce blackness in a broadband center, action spectra were unimodal and identical to functions obtained by heterochromatic flicker photometry. Tests of additivity revealed that when blackness is induced by broadband surround into a bichromatic center, there is an additivity failure of the cancellation type. This additivity failure indicates that blackness induction is influenced, in part, by signals from opponent-chromatic pathways. A quantitative model is presented to account for these data. This model assumes that blackness induction is determined by the ratio of responses to the stimulus center and the annulus, and while signals form the annulus are based only on achromatic information, responses from the center are based on both chromatic and achromatic properties of the stimulus.

Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study.

PubMed

El-Sayed, Mohamed I; Ali, Amany M; Sayed, Heba A; Zaky, Eman M

2010-12-24

We conducted a retrospective analysis to investigate treatment results and prognostic factors of pediatric neuroblastoma patients. This retrospective study was carried out analyzing the medical records of patients with the pathological diagnosis of neuroblastoma seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to patients with residual primary tumor was applied. Overall and event free survival (OAS and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in OAS and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates. Fifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year OAS and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age >1 year of age, N-MYC amplification, and high risk group. The majority of patients (68%) presented in high risk group, where treatment outcome was poor, as only 21% of patients survived for 3 year. Multivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to patients with residual tumor evident after induction chemotherapy and surgery. Future attempts to improve OAS in high risk group patients with aggressive chemotherapy and bone marrow transplantation should be considered.

Minor displacements in the insertion site provoke major differences in the induction of antibody responses by chimeric parvovirus-like particles.

PubMed

Rueda, P; Hurtado, A; del Barrio, M; Martínez-Torrecuadrada, J L; Kamstrup, S; Leclerc, C; Casal, J I

1999-10-10

An antigen-delivery system based on hybrid virus-like particles (VLPs) formed by the self-assembly of the capsid VP2 protein of canine parvovirus (CPV) and expressing foreign peptides was investigated. In this report, we have studied the effects of inserting the poliovirus C3:B epitope in the four loops and the C terminus of the CPV VP2 on the particle structure and immunogenicity. Epitope insertions in the four loops allowed the recovery of capsids in all of the mutants. However, only insertions of the C3:B epitope in VP2 residue 225 of the loop 2 were able to elicit a significant anti-peptide antibody response, but not poliovirus-neutralizing antibodies, probably because residue 225 is located in an small depression of the surface. To fine modulate the insertion site in loop 2, a cassette-mutagenesis was carried out to insert the epitope in adjacent positions 226, 227, and 228. The epitope C3:B inserted into these positions was well recognized by the specific monoclonal antibody C3 by immunoelectron microscopy. BALB/c mice immunized with these chimeric C3:B CPV:VLPs were able to elicit an strong neutralizing antibody response (>3 log(10) units) against poliovirus type 1 (Mahoney strain). Therefore, minor displacements in the insertion place cause dramatic changes in the accessibility of the epitope and the induction of antibody responses. Copyright 1999 Academic Press.

Petrophysical evaluation of subterranean formations

DOEpatents

Klein, James D; Schoderbek, David A; Mailloux, Jason M

2013-05-28

Methods and systems are provided for evaluating petrophysical properties of subterranean formations and comprehensively evaluating hydrate presence through a combination of computer-implemented log modeling and analysis. Certain embodiments include the steps of running a number of logging tools in a wellbore to obtain a variety of wellbore data and logs, and evaluating and modeling the log data to ascertain various petrophysical properties. Examples of suitable logging techniques that may be used in combination with the present invention include, but are not limited to, sonic logs, electrical resistivity logs, gamma ray logs, neutron porosity logs, density logs, NRM logs, or any combination or subset thereof.

Avian responses to selective logging shaped by species traits and logging practices

PubMed Central

Burivalova, Zuzana; Lee, Tien Ming; Giam, Xingli; Şekercioğlu, Çağan Hakkı; Wilcove, David S.; Koh, Lian Pin

2015-01-01

Selective logging is one of the most common forms of forest use in the tropics. Although the effects of selective logging on biodiversity have been widely studied, there is little agreement on the relationship between life-history traits and tolerance to logging. In this study, we assessed how species traits and logging practices combine to determine species responses to selective logging, based on over 4000 observations of the responses of nearly 1000 bird species to selective logging across the tropics. Our analysis shows that species traits, such as feeding group and body mass, and logging practices, such as time since logging and logging intensity, interact to influence a species' response to logging. Frugivores and insectivores were most adversely affected by logging and declined further with increasing logging intensity. Nectarivores and granivores responded positively to selective logging for the first two decades, after which their abundances decrease below pre-logging levels. Larger species of omnivores and granivores responded more positively to selective logging than smaller species from either feeding group, whereas this effect of body size was reversed for carnivores, herbivores, frugivores and insectivores. Most importantly, species most negatively impacted by selective logging had not recovered approximately 40 years after logging cessation. We conclude that selective timber harvest has the potential to cause large and long-lasting changes in avian biodiversity. However, our results suggest that the impacts can be mitigated to a certain extent through specific forest management strategies such as lengthening the rotation cycle and implementing reduced impact logging. PMID:25994673

Hardwood log grades and lumber grade yields for factory lumber logs

Treesearch

Leland F. Hanks; Glenn L. Gammon; Robert L. Brisbin; Everette D. Rast

1980-01-01

The USDA Forest Service Standard Grades for Hardwood Factory Lumber Logs are described, and lumber grade yields for 16 species and 2 species groups are presented by log grade and log diameter. The grades enable foresters, log buyers, and log sellers to select and grade those log suitable for conversion into standard factory grade lumber. By using the apropriate lumber...

Complexation of cadmium to sulfur and oxygen functional groups in an organic soil

NASA Astrophysics Data System (ADS)

Karlsson, Torbjörn; Elgh-Dalgren, Kristin; Björn, Erik; Skyllberg, Ulf

2007-02-01

Cadmium (Cd) is a toxic trace element and due to human activities soils and waters are contaminated by Cd both on a local and global scale. It is widely accepted that chemical interactions with functional groups of natural organic matter (NOM) is vital for the bioavailability and mobility of trace elements. In this study the binding strength of cadmium (Cd) to soil organic matter (SOM) was determined in an organic (49% organic C) soil as a function of reaction time, pH and Cd concentration. In experiments conducted at native Cd concentrations in soil (0.23 μg g -1 dry soil), halides (Cl, Br) were used as competing ligands to functional groups in SOM. The concentration of Cd in the aqueous phase was determined by isotope-dilution (ID) inductively-coupled-plasma-mass-spectrometry (ICP-MS), and the activity of Cd 2+ was calculated from the well-established Cd-halide constants. At higher Cd loading (500-54,000 μg g -1), the Cd 2+ activity was directly determined by an ion-selective electrode (ISE). On the basis of results from extended X-ray absorption fine structure (EXAFS) spectroscopy, a model with one thiolate group (RS -) was used to describe the complexation (Cd 2+ + RS - ⇆ CdSR +; log KCdSR) at native Cd concentrations. The concentration of thiols (RSH; 0.047 mol kg -1 C) was independently determined by X-ray absorption near-edge structure (XANES) spectroscopy. Log KCdSR values of 11.2-11.6 (p Ka for RSH = 9.96), determined in the pH range 3.1-4.6, compare favorably with stability constants for the association between Cd and well-defined thiolates like glutathione. In the concentration range 500-54,000 μg Cd g -1, a model consisting of one thiolate and one carboxylate (RCOO -) gave the best fit to data, indicating an increasing role for RCOOH groups as RSH groups become saturated. The determined log KCdOOCR of 3.2 (Cd 2+ + RCOO - ⇆ CdOOCR +; log KCdOOCR; p Ka for RCOOH = 4.5) is in accordance with stability constants determined for the association between Cd and well-defined carboxylates. Given a concentration of reduced sulfur groups of 0.2% or higher in NOM, we conclude that the complexation to organic RSH groups may control the speciation of Cd in soils, and most likely also in surface waters, with a total concentration less than 5 mg Cd g -1 organic C.

Improved grading system for structural logs for log homes

Treesearch

D.W. Green; T.M. Gorman; J.W. Evans; J.F. Murphy

2004-01-01

Current grading standards for logs used in log home construction use visual criteria to sort logs into either “wall logs” or structural logs (round and sawn round timbers). The conservative nature of this grading system, and the grouping of stronger and weaker species for marketing purposes, probably results in the specification of logs with larger diameter than would...

A CORRELATION BETWEEN RADIATION TOLERANCE AND NUCLEAR SURFACE AREA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iversen, S.

1962-09-22

Sparrow and Miksche (Science, 134:282) determined the dose (r/day) required to produce severe growth inhibition in 23 species of plants and found a linear relationship between log nuclear volume and log dose. The following equations hold for 6 species: log nuclear volume - 4.42 -0.82 log dose and log nuclear volume = 1.66 + 0.66 log (DNA content). If all the nuclear DNA is distributed in two peripheral zones, the equations also hold: 2(log nuclear surface area) - 1.33(log nuclear volume) - 2.21 + 0.88 log(DNA content) and 5.88-- 1.09 log dose. For the 23 species, the equation was obtained:more » 2(log nuclear surface area) = 5.41 -- 0.97 log dose. All the slopes are close to the expected value of 1.00. (D.L.C.)« less

Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial

PubMed Central

Matloub, Yousif; Broxson, Emmett; La, Mei; Yanofsky, Rochelle; Sather, Harland; Hutchinson, Ray; Heerema, Nyla A.; Sorrell, April D.; Masterson, Margaret; Bleyer, Archie; Gaynon, Paul S.

2010-01-01

The Children's Cancer Group 1952 (CCG-1952) clinical trial studied the substitution of oral 6-thioguanine (TG) for 6-mercaptopurine (MP) and triple intrathecal therapy (ITT) for intrathecal methotrexate (IT-MTX) in the treatment of standard-risk acute lymphoblastic leukemia. After remission induction, 2027 patients were randomized to receive MP (n = 1010) or TG (n = 1017) and IT-MTX (n = 1018) or ITT (n = 1009). The results of the thiopurine comparison are as follows. The estimated 7-year event-free survival (EFS) for subjects randomized to TG was 84.1% (± 1.8%) and to MP was 79.0% (± 2.1%; P = .004 log rank), although overall survival was 91.9% (± 1.4%) and 91.2% (± 1.5%), respectively (P = .6 log rank). The TG starting dose was reduced from 60 to 50 mg/m2 per day after recognition of hepatic veno-occlusive disease (VOD). A total of 257 patients on TG (25%) developed VOD or disproportionate thrombocytopenia and switched to MP. Once portal hypertension occurred, all subjects on TG were changed to MP. The benefit of randomization to TG over MP, as measured by EFS, was evident primarily in boys who began TG at 60 mg/m2 (relative hazard rate [RHR] 0.65, P = .002). The toxicities of TG preclude its protracted use as given in this study. This study is registered at http://clinicaltrials.gov as NCT00002744. PMID:20124218

Evaluation of ecotoxicological effects of benzophenone UV filters: Luminescent bacteria toxicity, genotoxicity and hormonal activity.

PubMed

Zhang, Qiuya; Ma, Xiaoyan; Dzakpasu, Mawuli; Wang, Xiaochang C

2017-08-01

The widespread use of organic ultraviolet (UV) filters in personal care products raises concerns about their potentially hazardous effects on human and ecosystem health. In this study, the toxicities of four commonly used benzophenones (BPs) UV filters including benzophenone (BP), 2-Hydroxybenzophenone (2HB), 2-Hydroxy-4-methoxybenzophenone (BP3), and 2-Hydroxy-4-methoxybenzophenone-5-sulfonicacid (BP4) in water were assayed in vitro using Vibrio fischeri, SOS/umu assay, and yeast estrogen screen (YES) assay, as well as in vivo using zebrafish larvae. The results showed that the luminescent bacteria toxicity, expressed as logEC 50 , increased with the lipophilicity (logKow) of BPs UV filters. Especially, since 2HB, BP3 and BP4 had different substituent groups, namely -OH, -OCH 3 and -SO 3 H, respectively, these substituent functional groups had a major contribution to the lipophilicity and acute toxicity of these BPs. Similar tendency was observed for the genotoxicity, expressed as the value of induction ratio=1.5. Moreover, all the target BPs UV filters showed estrogenic activity, but no significant influences of lipophilicity on the estrogenicity were observed, with BP3 having the weakest estrogenic efficiency in vitro. Although BP3 displayed no noticeable adverse effects in any in vitro assays, multiple hormonal activities were observed in zebrafish larvae including estrogenicity, anti-estrogenicity and anti-androgenicity by regulating the expression of target genes. The results indicated potential hazardous effects of BPs UV filters and the importance of the combination of toxicological evaluation methods including in vitro and in vivo assays. Copyright © 2017 Elsevier Inc. All rights reserved.

Cross-validation and Peeling Strategies for Survival Bump Hunting using Recursive Peeling Methods

PubMed Central

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

2015-01-01

We introduce a framework to build a survival/risk bump hunting model with a censored time-to-event response. Our Survival Bump Hunting (SBH) method is based on a recursive peeling procedure that uses a specific survival peeling criterion derived from non/semi-parametric statistics such as the hazards-ratio, the log-rank test or the Nelson--Aalen estimator. To optimize the tuning parameter of the model and validate it, we introduce an objective function based on survival or prediction-error statistics, such as the log-rank test and the concordance error rate. We also describe two alternative cross-validation techniques adapted to the joint task of decision-rule making by recursive peeling and survival estimation. Numerical analyses show the importance of replicated cross-validation and the differences between criteria and techniques in both low and high-dimensional settings. Although several non-parametric survival models exist, none addresses the problem of directly identifying local extrema. We show how SBH efficiently estimates extreme survival/risk subgroups unlike other models. This provides an insight into the behavior of commonly used models and suggests alternatives to be adopted in practice. Finally, our SBH framework was applied to a clinical dataset. In it, we identified subsets of patients characterized by clinical and demographic covariates with a distinct extreme survival outcome, for which tailored medical interventions could be made. An R package PRIMsrc (Patient Rule Induction Method in Survival, Regression and Classification settings) is available on CRAN (Comprehensive R Archive Network) and GitHub. PMID:27034730

Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

PubMed Central

Screnci, D; McKeage, M J; Galettis, P; Hambley, T W; Palmer, B D; Baguley, B C

2000-01-01

Previous work has shown platinum drugs to differ in their effects on the peripheral nervous system. To test whether their differential toxicity was due to differences in their partitioning into the peripheral nervous system, we correlated the hydrophobicity, reactivity, tissue accumulation and neurotoxicity of a series of eight platinum analogues. Neurotoxicity was detected by measuring sensory nerve conduction velocity (SNCV) in Wistar rats treated twice per week at the maximum tolerated dose. Tissue platinum concentrations were measured by inductively coupled plasma mass spectrometry. Hydrophobicity (log P) was measured using an octanol-aqueous shake-flask method. The half-life of platinum drug binding to plasma proteins in vitro was determined. The cumulative dose causing altered SNCV ranged from 15 to > 2050 μmol kg−1. Ranking of the compounds by their neurotoxic potency in rats (oxaliplatin >R,R -(DACH)PtC4> ormaplatin >S,S -(DACH)PtCl4>S,S -(DACH)Pt oxalato > cisplatin > carboplatin > JM216) correlated with the frequency of neurotoxicity in patients (r> 0.99;P< 0.05). Ranking the compounds by their peripheral nerve accumulation was cisplatin > carboplatin > oxaliplatin >R,R -(DACH)PtCl4≈S,S -(DACH)PtCl4and did not correlate with neurotoxicity. Log P ranged from – 2.53 to –0.16 but did not correlate with neurotoxicity. Log P correlated inversely with platinum accumulation in dorsal root ganglia (r2= 0.99;P = 0.04), sural nerve (r2= 0.85;P = 0.025), sciatic nerve (r2= 0.98;P = 0.0012), spinal cord (r2= 0.97, P = 0.018) and brain (r2= 0.98, P = 0.001). Reactivity correlated with neurotoxicity potency in rats (r2= 0.89, P = 0.0005) and with the frequency of neurotoxicity in patients (r2= 0.99, P = 0.0002). The hydrophilicity of platinum drugs correlates with platinum sequestration in the peripheral nervous system but not with neurotoxicity. Differences in the reactivity of platinum complexes accounts for some of the variation in their neurotoxicity. © 2000 Cancer Research Campaign PMID:10732773

The impact of a personal digital assistant (PDA) case log in a medical student clerkship.

PubMed

Ho, Kendall; Lauscher, Helen Novak; Broudo, Marc; Jarvis-Selinger, Sandra; Fraser, Joan; Hewes, Deborah; Scott, Ian

2009-10-01

Medical education literature emphasizes that reflection and self-audit are pivotal steps in learning and that personal digital assistants (PDAs) have potential as decision support tools. The purpose was to examine the efficacy of PDA-based resources and patient-encounter logging systems among 3rd-year medical clerks during pediatrics rotations. Students in rotations were assigned to control (using paper-based logs and references) or intervention groups (using PDA-based logs and resources). Students completed pre- and postrotation Paediatrics Competency Surveys, participated in focus groups, and were compared on year-end examination grades. Use of PDA logs far outweighed that of paper logs (1,020 PDA logs and 87 paper logs). PDA logs were ranked significantly higher in enhancing learning and reflection than paper logs (t = 2.52, p < .01). PDA logs also facilitated specific learning experiences. PDA-based patient-encounter logs appear to be effective case documentation and reflection tools. The difference in number of logs between control and intervention groups demonstrates the utility of the PDA for "point-of-care" patient logging.

House log drying rates in southeast Alaska for covered and uncovered softwood logs

Treesearch

David Nicholls; Allen Brackley

2009-01-01

Log moisture content has an important impact on many aspects of log home construction, including log processing, transportation costs, and dimensional stability in use. Air-drying times for house logs from freshly harvested trees can depend on numerous factors including initial moisture content, log diameter, bark condition, and environmental conditions during drying....

Effects of log defects on lumber recovery.

Treesearch

James M. Cahill; Vincent S. Cegelka

1989-01-01

The impact of log defects on lumber recovery and the accuracy of cubic log scale deductions were evaluated from log scale and product recovery data for more than 3,000 logs. Lumber tally loss was estimated by comparing the lumber yield of sound logs to that of logs containing defects. The data were collected at several product recovery studies; they represent most of...

A Space-Saving Approximation Algorithm for Grammar-Based Compression

NASA Astrophysics Data System (ADS)

Sakamoto, Hiroshi; Maruyama, Shirou; Kida, Takuya; Shimozono, Shinichi

A space-efficient approximation algorithm for the grammar-based compression problem, which requests for a given string to find a smallest context-free grammar deriving the string, is presented. For the input length n and an optimum CFG size g, the algorithm consumes only O(g log g) space and O(n log*n) time to achieve O((log*n)log n) approximation ratio to the optimum compression, where log*n is the maximum number of logarithms satisfying log log…log n > 1. This ratio is thus regarded to almost O(log n), which is the currently best approximation ratio. While g depends on the string, it is known that g =Ω(log n) and g=\\\\Omega(\\\\log n) and g=O\\\\left(\\\\frac{n}{log_kn}\\\\right) for strings from k-letter alphabet[12].

Accurately determining log and bark volumes of saw logs using high-resolution laser scan data

Treesearch

R. Edward Thomas; Neal D. Bennett

2014-01-01

Accurately determining the volume of logs and bark is crucial to estimating the total expected value recovery from a log. Knowing the correct size and volume of a log helps to determine which processing method, if any, should be used on a given log. However, applying volume estimation methods consistently can be difficult. Errors in log measurement and oddly shaped...

Vadose Zone Transport Field Study: Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gee, Glendon W.; Ward, Anderson L.

2001-11-30

Studies were initiated at the Hanford Site to evaluate the process controlling the transport of fluids in the vadose zone and to develop a reliable database upon which vadose-zone transport models can be calibrated. These models are needed to evaluate contaminant migration through the vadose zone to underlying groundwaters at Hanford. A study site that had previously been extensively characterized using geophysical monitoring techniques was selected in the 200 E Area. Techniques used previously included neutron probe for water content, spectral gamma logging for radionuclide tracers, and gamma scattering for wet bulk density. Building on the characterization efforts of themore » past 20 years, the site was instrumented to facilitate the comparison of nine vadose-zone characterization methods: advanced tensiometers, neutron probe, electrical resistance tomography (ERT), high-resolution resistivity (HRR), electromagnetic induction imaging (EMI), cross-borehole radar (XBR), and cross-borehole seismic (XBS). Soil coring was used to obtain soil samples for analyzing ionic and isotopic tracers.« less

Cross-Validation of Survival Bump Hunting by Recursive Peeling Methods.

PubMed

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J Sunil

2014-08-01

We introduce a survival/risk bump hunting framework to build a bump hunting model with a possibly censored time-to-event type of response and to validate model estimates. First, we describe the use of adequate survival peeling criteria to build a survival/risk bump hunting model based on recursive peeling methods. Our method called "Patient Recursive Survival Peeling" is a rule-induction method that makes use of specific peeling criteria such as hazard ratio or log-rank statistics. Second, to validate our model estimates and improve survival prediction accuracy, we describe a resampling-based validation technique specifically designed for the joint task of decision rule making by recursive peeling (i.e. decision-box) and survival estimation. This alternative technique, called "combined" cross-validation is done by combining test samples over the cross-validation loops, a design allowing for bump hunting by recursive peeling in a survival setting. We provide empirical results showing the importance of cross-validation and replication.

Cross-Validation of Survival Bump Hunting by Recursive Peeling Methods

PubMed Central

Dazard, Jean-Eudes; Choe, Michael; LeBlanc, Michael; Rao, J. Sunil

2015-01-01

We introduce a survival/risk bump hunting framework to build a bump hunting model with a possibly censored time-to-event type of response and to validate model estimates. First, we describe the use of adequate survival peeling criteria to build a survival/risk bump hunting model based on recursive peeling methods. Our method called “Patient Recursive Survival Peeling” is a rule-induction method that makes use of specific peeling criteria such as hazard ratio or log-rank statistics. Second, to validate our model estimates and improve survival prediction accuracy, we describe a resampling-based validation technique specifically designed for the joint task of decision rule making by recursive peeling (i.e. decision-box) and survival estimation. This alternative technique, called “combined” cross-validation is done by combining test samples over the cross-validation loops, a design allowing for bump hunting by recursive peeling in a survival setting. We provide empirical results showing the importance of cross-validation and replication. PMID:26997922

Comparative transcriptional profiling of two wheat genotypes, with contrasting levels of minerals in grains, shows expression differences during grain filling.

PubMed

Singh, Sudhir P; Jeet, Raja; Kumar, Jitendra; Shukla, Vishnu; Srivastava, Rakesh; Mantri, Shrikant S; Tuli, Rakesh

2014-01-01

Wheat is one of the most important cereal crops in the world. To identify the candidate genes for mineral accumulation, it is important to examine differential transcriptome between wheat genotypes, with contrasting levels of minerals in grains. A transcriptional comparison of developing grains was carried out between two wheat genotypes- Triticum aestivum Cv. WL711 (low grain mineral), and T. aestivum L. IITR26 (high grain mineral), using Affymetrix GeneChip Wheat Genome Array. The study identified a total of 580 probe sets as differentially expressed (with log2 fold change of ≥2 at p≤0.01) between the two genotypes, during grain filling. Transcripts with significant differences in induction or repression between the two genotypes included genes related to metal homeostasis, metal tolerance, lignin and flavonoid biosynthesis, amino acid and protein transport, vacuolar-sorting receptor, aquaporins, and stress responses. Meta-analysis revealed spatial and temporal signatures of a majority of the differentially regulated transcripts.

Analytical Fingerprint of Wolframite Ore Concentrates.

PubMed

Gäbler, Hans-Eike; Schink, Wilhelm; Goldmann, Simon; Bahr, Andreas; Gawronski, Timo

2017-07-01

Ongoing violent conflicts in Central Africa are fueled by illegal mining and trading of tantalum, tin, and tungsten ores. The credibility of document-based traceability systems can be improved by an analytical fingerprint applied as an independent method to confirm or doubt the documented origin of ore minerals. Wolframite (Fe,Mn)WO 4 is the most important ore mineral for tungsten and is subject to artisanal mining in Central Africa. Element concentrations of wolframite grains analyzed by laser ablation-inductively coupled plasma-mass spectrometry are used to establish the analytical fingerprint. The data from ore concentrate samples are multivariate, not normal or log-normal distributed. The samples cannot be regarded as representative aliquots of a population. Based on the Kolmogorov-Smirnov distance, a measure of similarity between a sample in question and reference samples from a database is determined. A decision criterion is deduced to recognize samples which do not originate from the declared mine site. © 2017 American Academy of Forensic Sciences.

Comparative Transcriptional Profiling of Two Wheat Genotypes, with Contrasting Levels of Minerals in Grains, Shows Expression Differences during Grain Filling

PubMed Central

Singh, Sudhir P.; Jeet, Raja; Kumar, Jitendra; Shukla, Vishnu; Srivastava, Rakesh; Mantri, Shrikant S.; Tuli, Rakesh

2014-01-01

Wheat is one of the most important cereal crops in the world. To identify the candidate genes for mineral accumulation, it is important to examine differential transcriptome between wheat genotypes, with contrasting levels of minerals in grains. A transcriptional comparison of developing grains was carried out between two wheat genotypes- Triticum aestivum Cv. WL711 (low grain mineral), and T. aestivum L. IITR26 (high grain mineral), using Affymetrix GeneChip Wheat Genome Array. The study identified a total of 580 probe sets as differentially expressed (with log2 fold change of ≥2 at p≤0.01) between the two genotypes, during grain filling. Transcripts with significant differences in induction or repression between the two genotypes included genes related to metal homeostasis, metal tolerance, lignin and flavonoid biosynthesis, amino acid and protein transport, vacuolar-sorting receptor, aquaporins, and stress responses. Meta-analysis revealed spatial and temporal signatures of a majority of the differentially regulated transcripts. PMID:25364903

Who Goes There? Measuring Library Web Site Usage.

ERIC Educational Resources Information Center

Bauer, Kathleen

2000-01-01

Discusses how libraries can gather data on the use of their Web sites. Highlights include Web server log files, including the common log file, referrer log file, and agent log file; log file limitations; privacy concerns; and choosing log analysis software, both free and commercial. (LRW)

Ultraviolet (UV)-reflective paint with ultraviolet germicidal irradiation (UVGI) improves decontamination of nosocomial bacteria on hospital room surfaces.

PubMed

Jelden, Katelyn C; Gibbs, Shawn G; Smith, Philip W; Hewlett, Angela L; Iwen, Peter C; Schmid, Kendra K; Lowe, John J

2017-06-01

An ultraviolet germicidal irradiation (UVGI) generator (the TORCH, ClorDiSys Solutions, Inc.) was used to compare the disinfection of surface coupons (plastic from a bedrail, stainless steel, and chrome-plated light switch cover) in a hospital room with walls coated with ultraviolet (UV)-reflective paint (Lumacept) or standard paint. Each surface coupon was inoculated with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus faecalis (VRE), placed at 6 different sites within a hospital room coated with UV-reflective paint or standard paint, and treated by 10 min UVC exposure (UVC dose of 0-688 mJ/cm 2 between sites with standard paint and 0-553 mJ/cm 2 with UV-reflective paint) in 8 total trials. Aggregated MRSA concentrations on plastic bedrail surface coupons were reduced on average by 3.0 log 10 (1.8 log 10 Geometric Standard Deviation [GSD]) with standard paint and 4.3 log 10 (1.3 log 10 GSD) with UV-reflective paint (p = 0.0005) with no significant reduction differences between paints on stainless steel and chrome. Average VRE concentrations were reduced by ≥4.9 log 10 (<1.2 log 10 GSD) on all surface types with UV-reflective paint and ≤4.1 log 10 (<1.7 log 10 GSD) with standard paint (p < 0.05). At 5 aggregated sites directly exposed to UVC light, MRSA concentrations on average were reduced by 5.2 log 10 (1.4 log 10 GSD) with standard paint and 5.1 log 10 (1.2 log 10 GSD) with UV-reflective paint (p = 0.017) and VRE by 4.4 log 10 (1.4 log 10 GSD) with standard paint and 5.3 log 10 (1.1 log 10 GSD) with UV-reflective paint (p < 0.0001). At one indirectly exposed site on the opposite side of the hospital bed from the UVGI generator, MRSA concentrations on average were reduced by 1.3 log 10 (1.7 log 10 GSD) with standard paint and 4.7 log 10 (1.3 log 10 GSD) with UV-reflective paint (p < 0.0001) and VRE by 1.2 log 10 (1.5 log 10 GSD) with standard paint and 4.6 log 10 (1.1 log 10 GSD) with UV-reflective paint (p < 0.0001). Coating hospital room walls with UV-reflective paint enhanced UVGI disinfection of nosocomial bacteria on various surfaces compared to standard paint, particularly at a surface placement site indirectly exposed to UVC light.

Effects of reduced-impact logging on fish assemblages in central Amazonia.

PubMed

Dias, Murilo S; Magnusson, William E; Zuanon, Jansen

2010-02-01

In Amazonia reduced-impact logging, which is meant to reduce environmental disturbance by controlling stem-fall directions and minimizing construction of access roads, has been applied to large areas containing thousands of streams. We investigated the effects of reduced-impact logging on environmental variables and the composition of fish in forest streams in a commercial logging concession in central Amazonia, Amazonas State, Brazil. To evaluate short-term effects, we sampled 11 streams before and after logging in one harvest area. We evaluated medium-term effects by comparing streams in 11 harvest areas logged 1-8 years before the study with control streams in adjacent areas. Each sampling unit was a 50-m stream section. The tetras Pyrrhulina brevis and Hemigrammus cf. pretoensis had higher abundances in plots logged > or =3 years before compared with plots logged <3 years before. The South American darter (Microcharacidium eleotrioides) was less abundant in logged plots than in control plots. In the short term, the overall fish composition did not differ two months before and immediately after reduced-impact logging. Temperature and pH varied before and after logging, but those differences were compatible with normal seasonal variation. In the medium term, temperature and cover of logs were lower in logged plots. Differences in ordination scores on the basis of relative fish abundance between streams in control and logged areas changed with time since logging, mainly because some common species increased in abundance after logging. There was no evidence of species loss from the logging concession, but differences in log cover and ordination scores derived from relative abundance of fish species persisted even after 8 years. For Amazonian streams, reduced-impact logging appears to be a viable alternative to clear-cut practices, which severely affect aquatic communities. Nevertheless, detailed studies are necessary to evaluated subtle long-term effects.

Degraded lands worth protecting: the biological importance of Southeast Asia's repeatedly logged forests

PubMed Central

Edwards, David P.; Larsen, Trond H.; Docherty, Teegan D. S.; Ansell, Felicity A.; Hsu, Wayne W.; Derhé, Mia A.; Hamer, Keith C.; Wilcove, David S.

2011-01-01

Southeast Asia is a hotspot of imperilled biodiversity, owing to extensive logging and forest conversion to oil palm agriculture. The degraded forests that remain after multiple rounds of intensive logging are often assumed to be of little conservation value; consequently, there has been no concerted effort to prevent them from being converted to oil palm. However, no study has quantified the biodiversity of repeatedly logged forests. We compare the species richness and composition of birds and dung beetles within unlogged (primary), once-logged and twice-logged forests in Sabah, Borneo. Logging had little effect on the overall richness of birds. Dung beetle richness declined following once-logging but did not decline further after twice-logging. The species composition of bird and dung beetle communities was altered, particularly after the second logging rotation, but globally imperilled bird species (IUCN Red List) did not decline further after twice-logging. Remarkably, over 75 per cent of bird and dung beetle species found in unlogged forest persisted within twice-logged forest. Although twice-logged forests have less biological value than primary and once-logged forests, they clearly provide important habitat for numerous bird and dung beetle species. Preventing these degraded forests from being converted to oil palm should be a priority of policy-makers and conservationists. PMID:20685713

Two-stage recovery of amphibian assemblages following selective logging of tropical forests.

PubMed

Adum, Gilbert Baase; Eichhorn, Markus Peter; Oduro, William; Ofori-Boateng, Caleb; Rödel, Mark-Oliver

2013-04-01

There is a lack of quantitative information on the effectiveness of selective-logging practices in ameliorating effects of logging on faunal communities. We conducted a large-scale replicated field study in 3 selectively logged moist semideciduous forests in West Africa at varying times after timber extraction to assess post logging effects on amphibian assemblages. Specifically, we assessed whether the diversity, abundance, and assemblage composition of amphibians changed over time for forest-dependent species and those tolerant of forest disturbance. In 2009, we sampled amphibians in 3 forests (total of 48 study plots, each 2 ha) in southwestern Ghana. In each forest, we established plots in undisturbed forest, recently logged forest, and forest logged 10 and 20 years previously. Logging intensity was constant across sites with 3 trees/ha removed. Recently logged forests supported substantially more species than unlogged forests. This was due to an influx of disturbance-tolerant species after logging. Simultaneously Simpson's index decreased, with increased in dominance of a few species. As time since logging increased richness of disturbance-tolerant species decreased until 10 years after logging when their composition was indistinguishable from unlogged forests. Simpson's index increased with time since logging and was indistinguishable from unlogged forest 20 years after logging. Forest specialists decreased after logging and recovered slowly. However, after 20 years amphibian assemblages had returned to a state indistinguishable from that of undisturbed forest in both abundance and composition. These results demonstrate that even with low-intensity logging (≤3 trees/ha) a minimum 20-year rotation of logging is required for effective conservation of amphibian assemblages in moist semideciduous forests. Furthermore, remnant patches of intact forests retained in the landscape and the presence of permanent brooks may aid in the effective recovery of amphibian assemblages. © 2012 Society for Conservation Biology.

Acoustic sorting models for improved log segregation

Treesearch

Xiping Wang; Steve Verrill; Eini Lowell; Robert J. Ross; Vicki L. Herian

2013-01-01

In this study, we examined three individual log measures (acoustic velocity, log diameter, and log vertical position in a tree) for their ability to predict average modulus of elasticity (MOE) and grade yield of structural lumber obtained from Douglas-fir (Pseudotsuga menziesii [Mirb. Franco]) logs. We found that log acoustic velocity only had a...

Proposed standard-weight (W(s)) equations for kokanee, golden trout and bull trout

USGS Publications Warehouse

Hyatt, M.H.; Hubert, W.A.

2000-01-01

We developed standard-weight (W(s)) equations for kokanee (lacustrine Oncorhynchus nerka), golden trout (O. aguabonita), and bull trout (Salvelinus confluentus) using the regression-line-percentile technique. The W(s) equation for kokanee of 120-550 mm TL is log10 W(s) = -5.062 + 3.033 log10 TL, when W(s) is in grams and TL is total length in millimeters; the English-unit equivalent is log10 W(s) = -3.458 + 3.033 log10 TL, when W(s) is in pounds and TL is total length in inches. The W(s) equation for golden trout of 120-530 mm TL is log10 W(s) = -5.088 + 3.041 log10 TL, with the English-unit equivalent being log10 W(s) = -3.473 + 3.041 log10 TL. The W(s) equation for bull trout of 120-850 mm TL is log10 W(s) = -5.327 + 3.115 log10 TL, with the English-unit equivalent being log10 W(s) = -3.608 + 3.115 log10 TL.

32 CFR 700.846 - Status of logs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Officers Afloat § 700.846 Status of logs. The deck log, the engineering log, the compass record, the bearing hooks, the engineer's bell book, and any records generated by automated data logging equipment...

Log-Concavity and Strong Log-Concavity: a review

PubMed Central

Saumard, Adrien; Wellner, Jon A.

2016-01-01

We review and formulate results concerning log-concavity and strong-log-concavity in both discrete and continuous settings. We show how preservation of log-concavity and strongly log-concavity on ℝ under convolution follows from a fundamental monotonicity result of Efron (1969). We provide a new proof of Efron's theorem using the recent asymmetric Brascamp-Lieb inequality due to Otto and Menz (2013). Along the way we review connections between log-concavity and other areas of mathematics and statistics, including concentration of measure, log-Sobolev inequalities, convex geometry, MCMC algorithms, Laplace approximations, and machine learning. PMID:27134693

Induction of virulence gene expression in Staphylococcus aureus by pulmonary surfactant.

PubMed

Ishii, Kenichi; Adachi, Tatsuo; Yasukawa, Jyunichiro; Suzuki, Yutaka; Hamamoto, Hiroshi; Sekimizu, Kazuhisa

2014-04-01

We performed a genomewide analysis using a next-generation sequencer to investigate the effect of pulmonary surfactant on gene expression in Staphylococcus aureus, a clinically important opportunistic pathogen. RNA sequence (RNA-seq) analysis of bacterial transcripts at late log phase revealed 142 genes that were upregulated >2-fold following the addition of pulmonary surfactant to the culture medium. Among these genes, we confirmed by quantitative reverse transcription-PCR analysis that mRNA amounts for genes encoding ESAT-6 secretion system C (EssC), an unknown hypothetical protein (NWMN_0246; also called pulmonary surfactant-inducible factor A [PsiA] in this study), and hemolysin gamma subunit B (HlgB) were increased 3- to 10-fold by the surfactant treatment. Among the major constituents of pulmonary surfactant, i.e., phospholipids and palmitate, only palmitate, which is the most abundant fatty acid in the pulmonary surfactant and a known antibacterial substance, stimulated the expression of these three genes. Moreover, these genes were also induced by supplementing the culture with detergents. The induction of gene expression by surfactant or palmitate was not observed in a disruption mutant of the sigB gene, which encodes an alternative sigma factor involved in bacterial stress responses. Furthermore, each disruption mutant of the essC, psiA, and hlgB genes showed attenuation of both survival in the lung and host-killing ability in a murine pneumonia model. These findings suggest that S. aureus resists membrane stress caused by free fatty acids present in the pulmonary surfactant through the regulation of virulence gene expression, which contributes to its pathogenesis within the lungs of the host animal.

Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study

PubMed Central

2010-01-01

Background We conducted a retrospective analysis to investigate treatment results and prognostic factors of pediatric neuroblastoma patients. Methods This retrospective study was carried out analyzing the medical records of patients with the pathological diagnosis of neuroblastoma seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to patients with residual primary tumor was applied. Overall and event free survival (OAS and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in OAS and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates. Results Fifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year OAS and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age >1 year of age, N-MYC amplification, and high risk group. The majority of patients (68%) presented in high risk group, where treatment outcome was poor, as only 21% of patients survived for 3 year. Conclusion Multivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to patients with residual tumor evident after induction chemotherapy and surgery. Future attempts to improve OAS in high risk group patients with aggressive chemotherapy and bone marrow transplantation should be considered. PMID:21182799

Analysis of a novel protocol of combined induction chemotherapy and concurrent chemoradiation in unresected non-small-cell lung cancer: a ten-year experience with vinblastine, Cisplatin, and radiation therapy.

PubMed

Waters, Eugenie; Dingle, Brian; Rodrigues, George; Vincent, Mark; Ash, Robert; Dar, Rashid; Inculet, Richard; Kocha, Walter; Malthaner, Richard; Sanatani, Michael; Stitt, Larry; Yaremko, Brian; Younus, Jawaid; Yu, Edward

2010-07-01

The London Regional Cancer Program (LRCP) uses a unique schedule of induction plus concurrent chemoradiation, termed VCRT (vinblastine, cisplatin, and radiation therapy), for the treatment of a subset of unresectable stage IIIA and IIIB non-small-cell lung cancer (NSCLC). This analysis was conducted to better understand the outcomes in VCRT-treated patients. We report a retrospective analysis of a large cohort of patients who underwent VCRT at the LRCP over a 10-year period, from 1996 to 2006. The analysis focused on OS, toxicities, and the outcomes from completion surgery in a small subset of patients. A total of 294 patients were included and 5-year OS, determined using Kaplan-Meier methodology, was 19.8% with a MST of 18.2 months. Reported grade 3-4 toxicities included neutropenia (39%), anemia (10%), pneumonitis (1%), and esophagitis (3%). Significant differences in survival between groups of patients were demonstrated with log-rank tests for completion surgery, use of radiation therapy, and cisplatin dose. Similarly, Univariate Cox regression showed that completion surgery, use of radiation therapy, cisplatin dose, and vinblastine dose were associated with increased survival. This retrospective analysis of a large cohort of patients reveals an OS for VCRT comparable to that reported in the literature for other current combined chemoradiation protocols. The success of this protocol seems to be dose dependent and the outcomes in those who underwent completion surgery suggests that pathologic complete remission is possible for IIIA and IIIB NSCLC.

An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.

PubMed

Saito, Kazutoshi; Takenouchi, Osamu; Nukada, Yuko; Miyazawa, Masaaki; Sakaguchi, Hitoshi

2017-04-01

To evaluate chemicals (e.g. lipophilic chemicals, pre/pro-haptens) that are difficult to correctly evaluate using in vitro skin sensitization tests (e.g. DPRA, KeratinoSens or h-CLAT), we developed a novel in vitro test termed "Epidermal Sensitization Assay: EpiSensA" that uses reconstructed human epidermis. This assay is based on the induction of multiple marker genes (ATF3, IL-8, DNAJB4 and GCLM) related to two keratinocyte responses (inflammatory or cytoprotective) in the induction of skin sensitization. Here, we first confirmed the mechanistic relevance of these marker genes by focusing on key molecules that regulate keratinocyte responses in vivo (P2X 7 for inflammatory and Nrf2 for cytoprotective responses). The up-regulation of ATF3 and IL-8, or DNAJB4 and GCLM induced by the representative sensitizer 2,4-dinitrochlorobenzene in human keratinocytes was significantly suppressed by a P2X 7 specific antagonist KN-62, or by Nrf2 siRNA, respectively, which supported mechanistic relevance of marker genes. Moreover, the EpiSensA had sensitivity, specificity and accuracy of 93%, 100% and 93% for 29 lipophilic chemicals (logKow≥3.5), and of 96%, 75% and 88% for 43 hydrophilic chemicals including 11 pre/pro-haptens, compared with the LLNA. These results suggested that the EpiSensA could be a mechanism-based test applicable to broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Copyright © 2016 Elsevier Ltd. All rights reserved.

Preadaptation to Cold Stress in Salmonella enterica Serovar Typhimurium Increases Survival during Subsequent Acid Stress Exposure

PubMed Central

Shah, Jigna; Desai, Prerak T.; Chen, Dong; Stevens, John R.

2013-01-01

Salmonella is an important cause of bacterial food-borne gastroenteritis. Salmonella encounters multiple abiotic stresses during pathogen elimination methods used in food processing, and these stresses may influence its subsequent survivability within the host or in the environment. Upon ingestion, Salmonella is exposed to gastrointestinal acidity, a first line of the host innate defense system. This study tested the hypothesis that abiotic stresses encountered during food processing alter the metabolic mechanisms in Salmonella that enable survival and persistence during subsequent exposure to the host gastrointestinal acidic environment. Out of the four different abiotic stresses tested, viz., cold, peroxide, osmotic, and acid, preadaptation of the log-phase culture to cold stress (5°C for 5 h) significantly enhanced survival during subsequent acid stress (pH 4.0 for 90 min). The gene expression profile of Salmonella preadapted to cold stress revealed induction of multiple genes associated with amino acid metabolism, oxidative stress, and DNA repair, while only a few of the genes in the above-mentioned stress response and repair pathways were induced upon exposure to acid stress alone. Preadaptation to cold stress decreased the NAD+/NADH ratio and hydroxyl (OH·) radical formation compared with those achieved with the exposure to acid stress alone, indicating alteration of aerobic respiration and the oxidative state of the bacteria. The results from this study suggest that preadaptation to cold stress rescues Salmonella from the deleterious effect of subsequent acid stress exposure by induction of genes involved in stress response and repair pathways, by modification of aerobic respiration, and by redox modulation. PMID:24056458

Project MANTIS: A MANTle Induction Simulator for coupling geodynamic and electromagnetic modeling

NASA Astrophysics Data System (ADS)

Weiss, C. J.

2009-12-01

A key component to testing geodynamic hypotheses resulting from the 3D mantle convection simulations is the ability to easily translate the predicted physiochemical state to the model space relevant for an independent geophysical observation, such as earth's seismic, geodetic or electromagnetic response. In this contribution a new parallel code for simulating low-frequency, global-scale electromagnetic induction phenomena is introduced that has the same Earth discretization as the popular CitcomS mantle convection code. Hence, projection of the CitcomS model into the model space of electrical conductivity is greatly simplified, and focuses solely on the node-to-node, physics-based relationship between these Earth parameters without the need for "upscaling", "downscaling", averaging or harmonizing with some other model basis such as spherical harmonics. Preliminary performance tests of the MANTIS code on shared and distributed memory parallel compute platforms shows favorable scaling (>70% efficiency) for up to 500 processors. As with CitcomS, an OpenDX visualization widget (VISMAN) is also provided for 3D rendering and interactive interrogation of model results. Details of the MANTIS code will be briefly discussed here, focusing on compatibility with CitcomS modeling, as will be preliminary results in which the electromagnetic response of a CitcomS model is evaluated. VISMAN rendering of electrical tomography-derived electrical conductivity model overlain by an a 1x1 deg crustal conductivity map. Grey scale represents the log_10 magnitude of conductivity [S/m]. Arrows are horiztonal components of a hypothetical magnetospheric source field used to electromagnetically excite the conductivity model.

6. Log calving barn. Interior view showing log postandbeam support ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Log calving barn. Interior view showing log post-and-beam support system and animal stalls. - William & Lucina Bowe Ranch, Log Calving Barn, 230 feet south-southwest of House, Melrose, Silver Bow County, MT

Bacillus sp. Acting as Dual Role for Corrosion Induction and Corrosion Inhibition with Carbon Steel (CS)

PubMed Central

Karn, Santosh K.; Fang, Guan; Duan, Jizhou

2017-01-01

Present work investigated the role of five different bacteria species as a corrosion inducer as well as corrosion inhibitor with carbon steel (CS). We observed the ability of different bacteria species on the metal surface attachment, biofilm formation, and determined Peroxidase, Catalase enzyme activity in the detached biofilm from the CS surface. We found that each strain has diverse conduct for surface attachment like DS1 3.3, DS2 2.5, DS3 4.3, DS4 4.0, and DS5 4.71 log cfu/cm2 and for biofilm 8.3 log cfu/cm2. The enzyme Peroxidase, Catalase was found in huge concentration inside the biofilm Peroxidase was maximum for DS4 36.0 U/ml and least for DS3 19.54 U/ml. Whereas, Catalase was highest for DS4, DS5 70.14 U/ml and least 57.2 U/ml for DS2. Scanning electron microscopy (SEM) was conducted to examine the biofilm and electrochemical impedance spectroscopy (EIS) were utilized to observe corrosion in the presence of bacteria. The electrochemical results confirmed that DS1, DS3, DS4, and DS5 strains have statistically significant MIC-factors (Microbially Influenced Corrosion) of 5.46, 8.51, 2.36, and 1.04, while DS2 protective effect factor of 0.89. Weight reduction results with carbon steel likewise supports that corrosion was initiated by DS1 and DS3, while DS2 and DS5 have no any impact though with DS4 we watched less weight reduction however assumed no role in the corrosion. We established the relation of Peroxidase enzyme activity of the isolates. DS1, DS3 and having Peroxidase in the range 22.18, 19.54 U/ml which induce the corrosion whereas DS2 and DS5 having 28.57 and 27.0 U/ml has no any effect and DS4 36 U/ml has inhibitory effect, increasing concentration inhibiting the corrosion. For Catalase DS1, DS3 have 67.28, 61.57 U/ml which induce corrosion while DS2 and DS5 57.71 and 59.14 U/ml also has no effect whereas DS4 70.14 U/ml can inhibit corrosion. Results clearly express that in a specific range both enzymes can induce the corrosion. Our goals are to pursuit and locate the potential role of the enzyme in corrosion induction and inhibition. There is still further work is proceeded for the more profound perception. PMID:29114242

An integrated 3D log processing optimization system for small sawmills in central Appalachia

Treesearch

Wenshu Lin; Jingxin Wang

2013-01-01

An integrated 3D log processing optimization system was developed to perform 3D log generation, opening face determination, headrig log sawing simulation, fl itch edging and trimming simulation, cant resawing, and lumber grading. A circular cross-section model, together with 3D modeling techniques, was used to reconstruct 3D virtual logs. Internal log defects (knots)...

Defect detection on hardwood logs using high resolution three-dimensional laser scan data

Treesearch

Liya Thomas; Lamine Mili; Clifford A. Shaffer; Ed Thomas; Ed Thomas

2004-01-01

The location, type, and severity of external defects on hardwood logs and skills are the primary indicators of overall log quality and value. External defects provide hints about the internal log characteristics. Defect data would improve the sawyer's ability to process logs such that a higher valued product (lumber) is generated. Using a high-resolution laser log...

Logging legacies affect insect pollinator communities in southern Appalachian forests

Treesearch

Michelle M. Jackson; Monica G. Turner; Scott M. Pearson

2014-01-01

Many temperate deciduous forests are recovering from past logging, but the effects of logging legacies and environmental gradients on forest insect pollinators have not been well studied. In this study, we asked how pollinator abundance and community composition varied with distance from logging roads and elevation in old (logged >90 years ago) and young (logged 20–...

4. Log chicken house (far left foreground), log bunkhouse (far ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Log chicken house (far left foreground), log bunkhouse (far left background), one-room log cabin (left of center background), log root cellar (center), post-and-beam center in foreground, and blacksmith shop (far right foreground). View to southeast. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

Examining the Use of Internal Defect Information for Information-Augmented Hardwood Log Breakdown

Treesearch

Luis G. Occeña; Daniel L. Schmoldt; Suraphan Thawornwong

1997-01-01

In present-day hardwood sawmills, log breakdown is hampered by incomplete information about log geometry and internal features. When internal log scanning becomes operational, it will remove this roadblock and provide a complete view of each logâs interior. It is not currently obvious, however, how dramatically this increased level of information will improve log...

Modeling and validating the grabbing forces of hydraulic log grapples used in forest operations

Treesearch

Jingxin Wang; Chris B. LeDoux; Lihai Wang

2003-01-01

The grabbing forces of log grapples were modeled and analyzed mathematically under operating conditions when grabbing logs from compact log piles and from bunch-like log piles. The grabbing forces are closely related to the structural parameters of the grapple, the weight of the grapple, and the weight of the log grabbed. An operational model grapple was designed and...

The frequency and level of sweep in mixed hardwood saw logs in the eastern United States

Treesearch

Peter Hamner; Marshall S. White; Philip A. Araman

2007-01-01

Hardwood sawmills traditionally saw logs in a manner that either orients sawlines parallel to the log central axis (straight sawing) or the log surface (allowing for taper). Sweep is characterized as uniform curvature along the entire length of a log. For logs with sweep, lumber yield losses from straight and taper sawing increase with increasing levels of sweep. Curve...

SedMob: A mobile application for creating sedimentary logs in the field

NASA Astrophysics Data System (ADS)

Wolniewicz, Pawel

2014-05-01

SedMob is an open-source, mobile software package for creating sedimentary logs, targeted for use in tablets and smartphones. The user can create an unlimited number of logs, save data from each bed in the log as well as export and synchronize the data with a remote server. SedMob is designed as a mobile interface to SedLog: a free multiplatform package for drawing graphic logs that runs on PC computers. Data entered into SedMob are saved in the CSV file format, fully compatible with SedLog.

Impact of temperature, pH, and salinity changes on the physico-chemical properties of model naphthenic acids.

PubMed

Celsie, Alena; Parnis, J Mark; Mackay, Donald

2016-03-01

The effects of temperature, pH, and salinity change on naphthenic acids (NAs) present in oil-sands process wastewater were modeled for 55 representative NAs. COSMO-RS was used to estimate octanol-water (KOW) and octanol-air (KOA) partition ratios and Henry's law constants (H). Validation with experimental carboxylic acid data yielded log KOW and log H RMS errors of 0.45 and 0.55 respectively. Calculations of log KOW, (or log D, for pH-dependence), log KOA and log H (or log HD, for pH-dependence) were made for model NAs between -20 °C and 40 °C, pH between 0 and 14, and salinity between 0 and 3 g NaCl L(-1). Temperature increase by 60 °C resulted in 3-5 log unit increase in H and a similar magnitude decrease in KOA. pH increase above the NA pKa resulted in a dramatic decrease in both log D and log HD. Salinity increase over the 0-3 g NaCl L(-1) range resulted in a 0.3 log unit increase on average for KOW and H values. Log KOW values of the sodium salt and anion of the conjugate base were also estimated to examine their potential for contribution to the overall partitioning of NAs. Sodium salts and anions of naphthenic acids are predicted to have on average 4 log units and 6 log units lower log KOW values, respectively, with respect to the corresponding neutral NA. Partitioning properties are profoundly influenced by the by the relative prevailing pH and the substance's pKa at the relevant temperature. Copyright © 2015 Elsevier Ltd. All rights reserved.

AML outcome: role of nucleotide excision repair polymorphisms in intermediate risk patients

PubMed Central

Strom, Sara S; Estey, Elihu H; Outschoorn, Ubaldo Martinez; Guillermo, Garcia-Manero

2010-01-01

Purpose Acute Myeloid Leukemia (AML) is frequently associated with genetic abnormalities. Based on pre-treatment cytogenetics, patients are classified into favorable, intermediate and poor subgroups. Cytogenetics predicts treatment outcome for the favorable and poor subgroups but not for the intermediate subgroup. Polymorphisms within the nucleotide excision repair (NER) pathway may lead to inter-individual differences in DNA repair capacity (DRC) which could influence outcome. Methods We studied the role of 6 polymorphisms (ERCC1 Gln504Lys, XPD Lys751Gln, XPC Ala499Val, XPC Lys939Gln, XPG Asp1104His, and CCNH Val270Ala) within NER pathway on overall and disease-free survival among 170 adult de-novo AML patients with intermediate cytogenetics [diploid (n=117); non-diploid (n=53)], treated with induction chemotherapy. Kaplan-Meier methods and Cox proportional hazards models were performed. Results Diploid patients with the XPD AC/CC genotype survived shorter than those with the wild-type (AA) genotype (median survival 22 vs. 40 months, log-rank p = 0.03). Similarly diploid patients with XPC CT/TT genotype survived shorter than those with the wild-type (CC) genotype (median survival 15 vs. 30 months, log-rank p = 0.02). Among diploid patients, after adjusting for clinical and socio-demographic variables, patients carrying both XPD AC/CC and XPC CT/TT had a greater than two-fold increased risk of dying compared to those with the wild-type genotypes (HR=2.49; 95%CI: 1.06–5.85). No significant associations were observed for disease-free survival in AML patients. Conclusion By reduced DRC, this combined genotype may result in greater susceptibility to treatment effects decreasing overall survival. These findings could in the future help in selecting treatment strategies for patients with normal cytogenetics. PMID:20141440

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

PubMed Central

Seymour, John F.; Butrym, Aleksandra; Wierzbowska, Agnieszka; Selleslag, Dominik; Jang, Jun Ho; Kumar, Rajat; Cavenagh, James; Schuh, Andre C.; Candoni, Anna; Récher, Christian; Sandhu, Irwindeep; Bernal del Castillo, Teresa; Al-Ali, Haifa Kathrin; Martinelli, Giovanni; Falantes, Jose; Noppeney, Richard; Stone, Richard M.; Minden, Mark D.; McIntyre, Heidi; Songer, Steve; Lucy, Lela M.; Beach, C. L.; Döhner, Hartmut

2015-01-01

This multicenter, randomized, open-label, phase 3 trial evaluated azacitidine efficacy and safety vs conventional care regimens (CCRs) in 488 patients age ≥65 years with newly diagnosed acute myeloid leukemia (AML) with >30% bone marrow blasts. Before randomization, a CCR (standard induction chemotherapy, low-dose ara-c, or supportive care only) was preselected for each patient. Patients then were assigned 1:1 to azacitidine (n = 241) or CCR (n = 247). Patients assigned to CCR received their preselected treatment. Median overall survival (OS) was increased with azacitidine vs CCR: 10.4 months (95% confidence interval [CI], 8.0-12.7 months) vs 6.5 months (95% CI, 5.0-8.6 months), respectively (hazard ratio [HR] was 0.85; 95% CI, 0.69-1.03; stratified log-rank P = .1009). One-year survival rates with azacitidine and CCR were 46.5% and 34.2%, respectively (difference, 12.3%; 95% CI, 3.5%-21.0%). A prespecified analysis censoring patients who received AML treatment after discontinuing study drug showed median OS with azacitidine vs CCR was 12.1 months (95% CI, 9.2-14.2 months) vs 6.9 months (95% CI, 5.1-9.6 months; HR, 0.76; 95% CI, 0.60-0.96; stratified log-rank P = .0190). Univariate analysis showed favorable trends for azacitidine compared with CCR across all subgroups defined by baseline demographic and disease features. Adverse events were consistent with the well-established safety profile of azacitidine. Azacitidine may be an important treatment option for this difficult-to-treat AML population. This trial was registered at www.clinicaltrials.gov as #NCT01074047. PMID:25987659

A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations

PubMed Central

Hata, Akihisa; Kurosawa, Hidetoshi; Endo, Yoko; Yamanaka, Kenzo; Fujitani, Noboru; Endo, Ginji

2016-01-01

Objectives: The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after seafood consumption. We estimated the urinary iAs+MMA concentration corresponding to iAs exposure. Methods: We used data from two arsenic speciation analyses of urine samples from 330 Bangladeshi with oral iAs exposure and 172 Japanese workers without occupational iAs exposure using high-performance liquid chromatography with inductively coupled plasma mass spectrometry. Results: iAs, MMA, and DMA, but not arsenobetaine (AsBe), were detected in the urine of the Bangladeshi subjects. The correlation between iAs+MMA+DMA and iAs+MMA was obtained as log (iAs+MMA) = 1.038 log (iAs+MMA+DMA) -0.658. Using the regression formula, the iAs+MMA value was calculated as 2.15 and 7.5 μg As/l, corresponding to 3 and 10 μg As/m3 of exposures, respectively. In the urine of the Japanese workers, arsenic was mostly excreted as AsBe. We used the 95th percentile of iAs+MMA (12.6 μg As/l) as the background value. The sum of the calculated and background values can be used as a biological indicator of iAs exposure. Conclusion: We propose 14.8 and 20.1 μg As/l of urinary iAs+MMA as the biological indicators of 3 and 10 μg As/m3 iAs exposure, respectively. PMID:27010090

Analysis of calibration materials to improve dual-energy CT scanning for petrophysical applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayyalasomavaiula, K.; McIntyre, D.; Jain, J.

2011-01-01

Dual energy CT-scanning is a rapidly emerging imaging technique employed in non-destructive evaluation of various materials. Although CT (Computerized Tomography) has been used for characterizing rocks and visualizing and quantifying multiphase flow through rocks for over 25 years, most of the scanning is done at a voltage setting above 100 kV for taking advantage of the Compton scattering (CS) effect, which responds to density changes. Below 100 kV the photoelectric effect (PE) is dominant which responds to the effective atomic numbers (Zeff), which is directly related to the photo electric factor. Using the combination of the two effects helps inmore » better characterization of reservoir rocks. The most common technique for dual energy CT-scanning relies on homogeneous calibration standards to produce the most accurate decoupled data. However, the use of calibration standards with impurities increases the probability of error in the reconstructed data and results in poor rock characterization. This work combines ICP-OES (inductively coupled plasma optical emission spectroscopy) and LIBS (laser induced breakdown spectroscopy) analytical techniques to quantify the type and level of impurities in a set of commercially purchased calibration standards used in dual-energy scanning. The Zeff data on the calibration standards with and without impurity data were calculated using the weighted linear combination of the various elements present and used in calculating Zeff using the dual energy technique. Results show 2 to 5% difference in predicted Zeff values which may affect the corresponding log calibrations. The effect that these techniques have on improving material identification data is discussed and analyzed. The workflow developed in this paper will translate to a more accurate material identification estimates for unknown samples and improve calibration of well logging tools.« less

INDUCTION OF MACULAR DETACHMENT FOR THE TREATMENT OF PERSISTENT OR RECURRENT IDIOPATHIC MACULAR HOLES.

PubMed

Szigiato, Andrei-Alexandru; Gilani, Fatimah; Walsh, Mark K; Mandelcorn, Efrem D; Muni, Rajeev H

2016-09-01

To analyze the efficacy of induced macular detachment for the treatment of persistent or recurrent idiopathic macular holes after treatment with one or more standard pars plana vitrectomies (PPVs) with internal limiting membrane peeling. This study is a retrospective consecutive case series of 10 patients who underwent a PPV with subretinal balanced salt solution injection from 2011 to 2014 to treat persistent or recurrent idiopathic macular holes. All patients had previously undergone PPV with internal limiting membrane peeling. Visual acuity, ocular examination findings, and optical coherence tomographic images were reviewed preoperatively and postoperatively to assess the anatomical and visual outcomes of this procedure. Nine of the 10 patients who underwent the procedure had closure of their macular holes postoperatively (90%) and remained closed 6 months postoperatively. Most patients reported a subjective visual improvement. A mean objective visual improvement of 16 letters (Early Treatment Diabetic Retinopathy Study, 0.324 logMAR) was seen between preoperative and 6-month postoperative assessments of all patients (pre = 1.490, post = 1.166; P = 0.022). Subgroup analysis of patients with successful closure revealed 20 letters of improvement (0.398 logMAR) in visual acuity (pre = 1.491, post = 1.093; P = 0.004). There were no intraoperative or postoperative complications. In eyes with persistent or recurrent idiopathic macular holes after standard PPV with internal limiting membrane peeling, repeat PPV with subretinal balanced salt solution injection to create a macular detachment may be a viable surgical treatment option. Our results show improved anatomical and visual outcomes postoperatively that compare favorably to other case series describing various surgical treatments for these challenging cases.

Prognostic nomogram and score to predict overall survival in locally advanced untreated pancreatic cancer (PROLAP)

PubMed Central

Vernerey, Dewi; Huguet, Florence; Vienot, Angélique; Goldstein, David; Paget-Bailly, Sophie; Van Laethem, Jean-Luc; Glimelius, Bengt; Artru, Pascal; Moore, Malcolm J; André, Thierry; Mineur, Laurent; Chibaudel, Benoist; Benetkiewicz, Magdalena; Louvet, Christophe; Hammel, Pascal; Bonnetain, Franck

2016-01-01

Background: The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better discrimination for overall survival (OS) at diagnosis is needed. We address this issue by developing and validating a prognostic nomogram and a score for OS in LAPC (PROLAP). Methods: Analyses were derived from 442 LAPC patients enrolled in the LAP07 trial. The prognostic ability of 30 baseline parameters was evaluated using univariate and multivariate Cox regression analyses. Performance assessment and internal validation of the final model were done with Harrell's C-index, calibration plot and bootstrap sample procedures. On the basis of the final model, a prognostic nomogram and a score were developed, and externally validated in 106 consecutive LAPC patients treated in Besançon Hospital, France. Results: Age, pain, tumour size, albumin and CA 19-9 were independent prognostic factors for OS. The final model had good calibration, acceptable discrimination (C-index=0.60) and robust internal validity. The PROLAP score has the potential to delineate three different prognosis groups with median OS of 15.4, 11.7 and 8.5 months (log-rank P<0.0001). The score ability to discriminate OS was externally confirmed in 63 (59%) patients with complete clinical data derived from a data set of 106 consecutive LAPC patients; median OS of 18.3, 14.1 and 7.6 months for the three groups (log-rank P<0.0001). Conclusions: The PROLAP nomogram and score can accurately predict OS before initiation of induction chemotherapy in LAPC-untreated patients. They may help to optimise clinical trials design and might offer the opportunity to define risk-adapted strategies for LAPC management in the future. PMID:27404456

Photodynamic inactivation of Staphylococcus aureus and Escherichia coli using a new bacteriochlorin as photosensitizer

NASA Astrophysics Data System (ADS)

Barboza, Diego D.; Martins, Laura C. A.; Corrêa, Thaila Quatrini; Geralde, Mariana Carreira; Pratavieira, Sebastião.; de Oliveira, Kleber Thiago; Uliana, Marciana P.; de Souza, Clovis W.

2018-02-01

In this study, we used bacteriochlorin as a photosensitizer, characterized by their low toxicity in the absence of light, presenting absorption around 780 nm, with the objective of evaluating their photodynamic inactivation potential on Staphylococcus aureus and Escherichia coli. Bacteriochlorins were synthesized from the extraction of bacteriochlorophylls from non-sulfurous purple bacteria and were then converted to bacteriochlorins. S. aureus and E. coli microorganisms were used in the planktonic and biofilm forms. For the formation of biofilms on glass coverslips, suspensions of the microorganisms at the concentration of 106 CFU/mL were inoculated into each well of a microplate. There was an exchange of culture medium (Tryptic Soy Broth - TSB) every 24 hours for 7 days, pre-washing the coverslips with a phosphate-buffered saline (PBS), to ensure that only adhered microorganisms were grown and then incubated at (36 +/- 1)°C between the middle exchanges. After 7 days of induction, the biofilm was mature, like those normally found in nature, and then it was applied different treatments (light doses associated with FS concentrations). At the end of the treatment, the coverslips underwent an ultrasonic disintegration, and the quantitative evaluation of viable cells was performed by plate counting using the plate method in Tryptic Soy Agar (TSA), incubating at (36 +/- 1)°C for 24 hours. The results showed that the PDI for E. coli was not successful even when it was more susceptible to the planktonic form, whereas for S. aureus the results showed a reduction in cell viability 6 logs for the planktonic forms, but lower to 1 log in biofilms. Therefore, novel studies using bacteriochlorins and surfactants will be performed to verify the potential of this alternative treatment method.

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis

PubMed Central

Kolar, Satya Sree N.; Luca, Vincenzo; Baidouri, Hasna; Mannino, Giuseppe; McDermott, Alison M.; Mangoni, Maria Luisa

2015-01-01

Pseudomonas aeruginosa is the primary bacterial pathogen causing contact lens related keratitis. Available ophthalmic agents have reduced efficacy and antimicrobial peptides (AMPs) hold promise as future antibiotics. Here we investigated the in vitro and in vivo anti-Pseudomonal activity of esculentin-1a(1-21)-NH2, derived from a frog skin AMP. The data revealed a minimum inhibitory concentration between 2 and 16 μM against reference strains or drug-resistant clinical isolates of P. aeruginosa without showing toxicity to human corneal epithelial cells up to 50 μM. At 1 μM the peptide rapidly killed bacterial cells and this activity was fully retained in 150 mM sodium chloride and 70% (v/v) human basal tears, particularly against the virulent ATCC 19660 strain. Furthermore, its dropwise administration at 40 μM to the ocular surface in a murine model of P. aeruginosa keratitis (three times daily, for 5 days post-infection) resulted in a significant reduction of infection. The mean clinical score was 2.89 ± 0.26 compared to 3.92 ± 0.08 for the vehicle control. In addition, the corneal level of viable bacteria in the peptide treated animals was significantly lower with a difference of 4 log10 colony counts, compared to 7.7 log10 cells recovered in the control. In parallel, recruitment of inflammatory cells was reduced by half compared to that found in the untreated eyes. Similar results were obtained when esculentin-1a(1-21)NH2 was applied prior to induction of keratitis. Overall, our findings highlight esculentin-1a(1-21)NH2 as an attractive candidate for the development of novel topical pharmaceuticals against Pseudomonas keratitis. PMID:25086859

Meta-Analysis of the Reduction of Norovirus and Male-Specific Coliphage Concentrations in Wastewater Treatment Plants.

PubMed

Pouillot, Régis; Van Doren, Jane M; Woods, Jacquelina; Plante, Daniel; Smith, Mark; Goblick, Gregory; Roberts, Christopher; Locas, Annie; Hajen, Walter; Stobo, Jeffrey; White, John; Holtzman, Jennifer; Buenaventura, Enrico; Burkhardt, William; Catford, Angela; Edwards, Robyn; DePaola, Angelo; Calci, Kevin R

2015-07-01

Human norovirus (NoV) is the leading cause of foodborne illness in the United States and Canada. Wastewater treatment plant (WWTP) effluents impacting bivalve mollusk-growing areas are potential sources of NoV contamination. We have developed a meta-analysis that evaluates WWTP influent concentrations and log10 reductions of NoV genotype I (NoV GI; in numbers of genome copies per liter [gc/liter]), NoV genotype II (NoV GII; in gc/liter), and male-specific coliphage (MSC; in number of PFU per liter), a proposed viral surrogate for NoV. The meta-analysis included relevant data (2,943 measurements) reported in the scientific literature through September 2013 and previously unpublished surveillance data from the United States and Canada. Model results indicated that the mean WWTP influent concentration of NoV GII (3.9 log10 gc/liter; 95% credible interval [CI], 3.5, 4.3 log10 gc/liter) is larger than the value for NoV GI (1.5 log10 gc/liter; 95% CI, 0.4, 2.4 log10 gc/liter), with large variations occurring from one WWTP to another. For WWTPs with mechanical systems and chlorine disinfection, mean log10 reductions were -2.4 log10 gc/liter (95% CI, -3.9, -1.1 log10 gc/liter) for NoV GI, -2.7 log10 gc/liter (95% CI, -3.6, -1.9 log10 gc/liter) for NoV GII, and -2.9 log10 PFU per liter (95% CI, -3.4, -2.4 log10 PFU per liter) for MSCs. Comparable values for WWTPs with lagoon systems and chlorine disinfection were -1.4 log10 gc/liter (95% CI, -3.3, 0.5 log10 gc/liter) for NoV GI, -1.7 log10 gc/liter (95% CI, -3.1, -0.3 log10 gc/liter) for NoV GII, and -3.6 log10 PFU per liter (95% CI, -4.8, -2.4 PFU per liter) for MSCs. Within WWTPs, correlations exist between mean NoV GI and NoV GII influent concentrations and between the mean log10 reduction in NoV GII and the mean log10 reduction in MSCs. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Comparison of log quality from even-aged and uneven-aged loblolly pine stands in south Arkansas

Treesearch

James M. Guldin; Michael W. Fitzpatrick

1991-01-01

Log grade, number of knots, and log volume of the first two logs, as well as form class of the butt log, were compared across three broad sawtimber categories among even-aged plantations, even-aged natural stands, and uneven-aged natural stands of loblolly pine (Pinus taeda L .) in Ashley County, AR. Trees from uneven-aged stands had butt logs of...

Reduction of lithologic-log data to numbers for use in the digital computer

USGS Publications Warehouse

Morgan, C.O.; McNellis, J.M.

1971-01-01

The development of a standardized system for conveniently coding lithologic-log data for use in the digital computer has long been needed. The technique suggested involves a reduction of the original written alphanumeric log to a numeric log by use of computer programs. This numeric log can then be retrieved as a written log, interrogated for pertinent information, or analyzed statistically. ?? 1971 Plenum Publishing Corporation.

Design considerations for large woody debris placement in stream enhancement projects. North American Journal of Fisheries Management

Treesearch

Robert H. Hilderbrand; A. Dennis Lemly; C. Andrew Dolloff; Kelly L. Harpster

1998-01-01

Log length exerted a critical influence in stabilizing large woody debris (LWD) pieces added as an experimental stream restoration technique. Logs longer than the average bank-full channel width (5.5 m) were significantly less likely to be displaced than logs shorter than this width. The longest log in stable log groups was significantly longer than the longest log in...

Thresholds of logging intensity to maintain tropical forest biodiversity.

PubMed

Burivalova, Zuzana; Sekercioğlu, Cağan Hakkı; Koh, Lian Pin

2014-08-18

Primary tropical forests are lost at an alarming rate, and much of the remaining forest is being degraded by selective logging. Yet, the impacts of logging on biodiversity remain poorly understood, in part due to the seemingly conflicting findings of case studies: about as many studies have reported increases in biodiversity after selective logging as have reported decreases. Consequently, meta-analytical studies that treat selective logging as a uniform land use tend to conclude that logging has negligible effects on biodiversity. However, selectively logged forests might not all be the same. Through a pantropical meta-analysis and using an information-theoretic approach, we compared and tested alternative hypotheses for key predictors of the richness of tropical forest fauna in logged forest. We found that the species richness of invertebrates, amphibians, and mammals decreases as logging intensity increases and that this effect varies with taxonomic group and continental location. In particular, mammals and amphibians would suffer a halving of species richness at logging intensities of 38 m(3) ha(-1) and 63 m(3) ha(-1), respectively. Birds exhibit an opposing trend as their total species richness increases with logging intensity. An analysis of forest bird species, however, suggests that this pattern is largely due to an influx of habitat generalists into heavily logged areas while forest specialist species decline. Our study provides a quantitative analysis of the nuanced responses of species along a gradient of logging intensity, which could help inform evidence-based sustainable logging practices from the perspective of biodiversity conservation. Copyright © 2014 Elsevier Ltd. All rights reserved.

WE-H-BRA-03: Development of a Model to Include the Evolution of Resistant Tumor Subpopulations Into the Treatment Optimization Process for Schedules Involving Targeted Agents in Chemoradiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grassberger, C; Paganetti, H

Purpose: To develop a model that includes the process of resistance development into the treatment optimization process for schedules that include targeted therapies. Further, to validate the approach using clinical data and to apply the model to assess the optimal induction period with targeted agents before curative treatment with chemo-radiation in stage III lung cancer. Methods: Growth of the tumor and its subpopulations is modeled by Gompertzian growth dynamics, resistance induction as a stochastic process. Chemotherapy induced cell kill is modeled by log-cell kill dynamics, targeted agents similarly but restricted to the sensitive population. Radiation induced cell kill is assumedmore » to follow the linear-quadratic model. The validation patient data consist of a cohort of lung cancer patients treated with tyrosine kinase inhibitors that had longitudinal imaging data available. Results: The resistance induction model was successfully validated using clinical trial data from 49 patients treated with targeted agents. The observed recurrence kinetics, with tumors progressing from 1.4–63 months, result in tumor growth equaling a median volume doubling time of 92 days [34–248] and a median fraction of pre-existing resistance of 0.035 [0–0.22], in agreement with previous clinical studies. The model revealed widely varying optimal time points for the use of curative therapy, reaching from ∼1m to >6m depending on the patient’s growth rate and amount of pre-existing resistance. This demonstrates the importance of patient-specific treatment schedules when targeted agents are incorporated into the treatment. Conclusion: We developed a model including evolutionary dynamics of resistant sub-populations with traditional chemotherapy and radiation cell kill models. Fitting to clinical data yielded patient specific growth rates and resistant fraction in agreement with previous studies. Further application of the model demonstrated how proper timing of chemo-radiation could minimize the probability of resistance, increasing tumor control significantly.« less

Salt at concentrations relevant to meat processing enhances Shiga toxin 2 production in Escherichia coli O157:H7.

PubMed

Harris, Shaun M; Yue, Wan-Fu; Olsen, Sarena A; Hu, Jia; Means, Warrie J; McCormick, Richard J; Du, Min; Zhu, Mei-Jun

2012-10-15

Escherichia coli (E. coli) O157:H7 remains a major food safety concern associated with meat, especially beef products. Shiga toxins (Stx) are key virulence factors produced by E. coli O157:H7 that are responsible for hemorrhagic colitis and Hemolytic Uremic Syndrome. Stx are heat stable and can be absorbed after oral ingestion. Despite the extensive study of E. coli O157:H7 survival during meat processing, little attention is paid to the production of Stx during meat processing. The objective of this study was to elucidate the effect of salt, an essential additive to processed meat, at concentrations relevant to meat processing (0%, 1%, 2%, 3%, W/V) on Stx2 production and Stx2 prophage induction by E. coli O157:H7 strains. For both E. coli O157:H7 86-24 and EDL933 strains, including 2% salt in LB broth decreased (P<0.05) E. coli O157:H7 population, but increased (P<0.05) Stx2 production (as measured relative to Log(10)CFU) compared to that of the control (1% salt). Supplementing 3% salt decreased (P<0.05) both E. coli O157:H7 number and Stx2 production. Quantitative RT-PCR indicated that stx2 mRNA expression in culture media containing 2% salt was greatly increased (P<0.05) compared to other salt concentrations. Consistent with enhanced Stx2 production and stx2 expression, the 2% salt group had highest lambdoid phage titer and stx2 prophage induction among all salt treatments. RecA is a key mediator of bacterial response to stress, which mediates prophage activation. Quantitative RT-PCR further indicated that recA mRNA expression was higher in both 2% and 3% salt than that of 0% and 1% salt treatments, indicating that stress was involved in enhanced Stx2 production. In conclusion, salt at the concentration used for meat processing enhances Stx production, a process linked to bacterial stress response and lambdoid prophage induction. Published by Elsevier B.V.

Automated potentiometric titrations in KCl/water-saturated octanol: method for quantifying factors influencing ion-pair partitioning.

PubMed

Scherrer, Robert A; Donovan, Stephen F

2009-04-01

The knowledge base of factors influencing ion pair partitioning is very sparse, primarily because of the difficulty in determining accurate log P(I) values of desirable low molecular weight (MW) reference compounds. We have developed a potentiometric titration procedure in KCl/water-saturated octanol that provides a link to log P(I) through the thermodynamic cycle of ionization and partitioning. These titrations have the advantage of being independent of the magnitude of log P, while maintaining a reproducibility of a few hundredths of a log P in the calculated difference between log P neutral and log P ion pair (diff (log P(N - I))). Simple model compounds can be used. The titration procedure is described in detail, along with a program for calculating pK(a)'' values incorporating the ionization of water in octanol. Hydrogen bonding and steric factors have a greater influence on ion pairs than they do on neutral species, yet these factors are missing from current programs used to calculate log P(I) and log D. In contrast to the common assumption that diff (log P(N - I)) is the same for all amines, they can actually vary more than 3 log units, as in our examples. A major factor affecting log P(I) is the ability of water and the counterion to approach the charge center. Bulky substituents near the charge center have a negative influence on log P(I). On the other hand, hydrogen bonding groups near the charge center have the opposite effect by lowering the free energy of the ion pair. The use of this titration method to determine substituent ion pair stabilization values (IPS) should bring about more accurate log D calculations and encourage species-specific QSAR involving log D(N) and log D(I). This work also brings attention to the fascinating world of nature's highly stabilized ion pairs.

Automated Potentiometric Titrations in KCl/Water-Saturated Octanol: Method for Quantifying Factors Influencing Ion-Pair Partitioning

PubMed Central

2009-01-01

The knowledge base of factors influencing ion pair partitioning is very sparse, primarily because of the difficulty in determining accurate log PI values of desirable low molecular weight (MW) reference compounds. We have developed a potentiometric titration procedure in KCl/water-saturated octanol that provides a link to log PI through the thermodynamic cycle of ionization and partitioning. These titrations have the advantage of being independent of the magnitude of log P, while maintaining a reproducibility of a few hundredths of a log P in the calculated difference between log P neutral and log P ion pair (diff (log PN − I)). Simple model compounds can be used. The titration procedure is described in detail, along with a program for calculating pKa′′ values incorporating the ionization of water in octanol. Hydrogen bonding and steric factors have a greater influence on ion pairs than they do on neutral species, yet these factors are missing from current programs used to calculate log PI and log D. In contrast to the common assumption that diff (log PN − I) is the same for all amines, they can actually vary more than 3 log units, as in our examples. A major factor affecting log PI is the ability of water and the counterion to approach the charge center. Bulky substituents near the charge center have a negative influence on log PI. On the other hand, hydrogen bonding groups near the charge center have the opposite effect by lowering the free energy of the ion pair. The use of this titration method to determine substituent ion pair stabilization values (IPS) should bring about more accurate log D calculations and encourage species-specific QSAR involving log DN and log DI. This work also brings attention to the fascinating world of nature’s highly stabilized ion pairs. PMID:19265385

2. Onroom log cabin (right), log root cellar (center), tworoom ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. On-room log cabin (right), log root cellar (center), two-room log cabin (left), and post-and-beam garage (background). View to southwest. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

Rill erosion in burned and salvage logged western montane forests: Effects of logging equipment type, traffic level, and slash treatment

NASA Astrophysics Data System (ADS)

Wagenbrenner, J. W.; Robichaud, P. R.; Brown, R. E.

2016-10-01

Following wildfires, forest managers often consider salvage logging burned trees to recover monetary value of timber, reduce fuel loads, or to meet other objectives. Relatively little is known about the cumulative hydrologic effects of wildfire and subsequent timber harvest using logging equipment. We used controlled rill experiments in logged and unlogged (control) forests burned at high severity in northern Montana, eastern Washington, and southern British Columbia to quantify rill overland flow and sediment production rates (fluxes) after ground-based salvage logging. We tested different types of logging equipment-feller-bunchers, tracked and wheeled skidders, and wheeled forwarders-as well as traffic levels and the addition of slash to skid trails as a best management practice. Rill experiments were done at each location in the first year after the fire and repeated in subsequent years. Logging was completed in the first or second post-fire year. We found that ground-based logging using heavy equipment compacted soil, reduced soil water repellency, and reduced vegetation cover. Vegetation recovery rates were slower in most logged areas than the controls. Runoff rates were higher in the skidder and forwarder plots than their respective controls in the Montana and Washington sites in the year that logging occurred, and the difference in runoff between the skidder and control plots at the British Columbia site was nearly significant (p = 0.089). Most of the significant increases in runoff in the logged plots persisted for subsequent years. The type of skidder, the addition of slash, and the amount of forwarder traffic did not significantly affect the runoff rates. Across the three sites, rill sediment fluxes were 5-1900% greater in logged plots than the controls in the year of logging, and the increases were significant for all logging treatments except the low use forwarder trails. There was no difference in the first-year sediment fluxes between the feller-buncher and tracked skidder plots, but the feller-buncher fluxes were lower than the values from the wheeled skidder plots. Manually adding slash after logging did not affect sediment flux rates. There were no significant changes in the control sediment fluxes over time, and none of the logging equipment impacted plots produced greater sediment fluxes than the controls in the second or third year after logging. Our results indicate that salvage logging increases the risk of sedimentation regardless of equipment type and amount of traffic, and that specific best management practices are needed to mitigate the hydrologic impacts of post-fire salvage logging.

Keystroke Logging in Writing Research: Using Inputlog to Analyze and Visualize Writing Processes

ERIC Educational Resources Information Center

Leijten, Marielle; Van Waes, Luuk

2013-01-01

Keystroke logging has become instrumental in identifying writing strategies and understanding cognitive processes. Recent technological advances have refined logging efficiency and analytical outputs. While keystroke logging allows for ecological data collection, it is often difficult to connect the fine grain of logging data to the underlying…

Methods of generating synthetic acoustic logs from resistivity logs for gas-hydrate-bearing sediments

USGS Publications Warehouse

Lee, Myung W.

1999-01-01

Methods of predicting acoustic logs from resistivity logs for hydrate-bearing sediments are presented. Modified time average equations derived from the weighted equation provide a means of relating the velocity of the sediment to the resistivity of the sediment. These methods can be used to transform resistivity logs into acoustic logs with or without using the gas hydrate concentration in the pore space. All the parameters except the unconsolidation constants, necessary for the prediction of acoustic log from resistivity log, can be estimated from a cross plot of resistivity versus porosity values. Unconsolidation constants in equations may be assumed without rendering significant errors in the prediction. These methods were applied to the acoustic and resistivity logs acquired at the Mallik 2L-38 gas hydrate research well drilled at the Mackenzie Delta, northern Canada. The results indicate that the proposed method is simple and accurate.

Seismic velocity deviation log: An effective method for evaluating spatial distribution of reservoir pore types

NASA Astrophysics Data System (ADS)

Shirmohamadi, Mohamad; Kadkhodaie, Ali; Rahimpour-Bonab, Hossain; Faraji, Mohammad Ali

2017-04-01

Velocity deviation log (VDL) is a synthetic log used to determine pore types in reservoir rocks based on a combination of the sonic log with neutron-density logs. The current study proposes a two step approach to create a map of porosity and pore types by integrating the results of petrographic studies, well logs and seismic data. In the first step, velocity deviation log was created from the combination of the sonic log with the neutron-density log. The results allowed identifying negative, zero and positive deviations based on the created synthetic velocity log. Negative velocity deviations (below - 500 m/s) indicate connected or interconnected pores and fractures, while positive deviations (above + 500 m/s) are related to isolated pores. Zero deviations in the range of [- 500 m/s, + 500 m/s] are in good agreement with intercrystalline and microporosities. The results of petrographic studies were used to validate the main pore type derived from velocity deviation log. In the next step, velocity deviation log was estimated from seismic data by using a probabilistic neural network model. For this purpose, the inverted acoustic impedance along with the amplitude based seismic attributes were formulated to VDL. The methodology is illustrated by performing a case study from the Hendijan oilfield, northwestern Persian Gulf. The results of this study show that integration of petrographic, well logs and seismic attributes is an instrumental way for understanding the spatial distribution of main reservoir pore types.

Predicting the Rate of River Bank Erosion Caused by Large Wood Log

NASA Astrophysics Data System (ADS)

Zhang, N.; Rutherfurd, I.; Ghisalberti, M.

2016-12-01

When a single tree falls into a river channel, flow is deflected and accelerated between the tree roots and the bank face, increasing shear stress and scouring the bank. The scallop shaped erosion increases the diversity of the channel morphology, but also causes concern for adjacent landholders. Concern about increased bank erosion is one of the main reasons for large wood to still be removed from channels in SE Australia. Further, the hydraulic effect of many logs in the channel can reduce overall bank erosion rates. Although both phenomena have been described before, this research develops a hydraulic model that estimates their magnitude, and tests and calibrates this model with flume and field measurements, with logs with various configurations and sizes. Specifically, the model estimates the change in excess shear stress on the bank associated . The model addresses the effect of the log angle, distance from bank, and log size and flow condition by solving the mass continuity and energy conservation between the cross section at the approaching flow and contracted flow. Then, we evaluate our model against flume experiment preformed with semi-realistic log models to represent logs in different sizes and decay stages by comparing the measured and simulated velocity increase in the gap between the log and the bank. The log angle, distance from bank, and flow condition are systemically varied for each log model during the experiment. Final, the calibrated model is compared with the field data collected in anabranching channels of Murray River in SE Australia where there are abundant instream logs and regulated and consistent high flow for irrigation. Preliminary results suggest that a log can significantly increase the shear stress on the bank, especially when it positions perpendicular to the flow. The shear stress increases with the log angle in a rising curve (The log angle is the angle between log trunk and flow direction. 0o means log is parallel to flow with canopy pointing downstream). However, the shear stress shows insignificant changes as the log is being moved close to the bank.

A Multi-temporal Analysis of Logging Impacts on Tropical Forest Structure Using Airborne Lidar Data

NASA Astrophysics Data System (ADS)

Keller, M. M.; Pinagé, E. R.; Duffy, P.; Longo, M.; dos-Santos, M. N.; Leitold, V.; Morton, D. C.

2017-12-01

The long-term impacts of selective logging on carbon cycling and ecosystem function in tropical-forests are still uncertain. Despite improvements in selective logging detection using satellite data, quantifying changes in forest structure from logging and recovery following logging is difficult using orbital data. We analyzed the dynamics of forest structure comparing logged and unlogged forests in the Eastern Brazilian Amazon (Paragominas Municipality, Pará State) using small footprint discrete return airborne lidar data acquired in 2012 and 2014. Logging operations were conducted at the 1200 ha study site from 2006 through 2013 using reduced impact logging techniques—management practices that minimize canopy and ground damage compared to more common conventional logging. Nevertheless, logging still reduced aboveground biomass by 10% to 20% in logged areas compared to intact forests. We aggregated lidar point-cloud data at spatial scales ranging from 50 m to 250 m and developed a binomial classification model based on the height distribution of lidar returns in 2012 and validated the model against the 2014 lidar acquisition. We accurately classified intact and logged forest classes compared with field data. Classification performance improved as spatial resolution increased (AUC = 0.974 at 250 m). We analyzed the differences in canopy gaps, understory damage (based on a relative density model), and biomass (estimated from total canopy height) of intact and logged classes. As expected, logging greatly increased both canopy gap formation and understory damage. However, while the area identified as canopy gap persisted for at least 8 years (from the oldest logging treatments in 2006 to the most recent lidar acquisition in 2014), the effects of ground damage were mostly erased by vigorous understory regrowth after about 5 years. The rate of new gap formation was 6 to 7 times greater in recently logged forests compared to undisturbed forests. New gaps opened at a rate of 1.8 times greater than background even 8 years following logging demonstrating the occurrence of delayed tree mortality. Our study showed that even low-intensity anthropogenic disturbances can cause persistent changes in tropical forest structure and dynamics.

The Spontaneous Ray Log: A New Aid for Constructing Pseudo-Synthetic Seismograms

NASA Astrophysics Data System (ADS)

Quadir, Adnan; Lewis, Charles; Rau, Ruey-Juin

2018-02-01

Conventional synthetic seismograms for hydrocarbon exploration combine the sonic and density logs, whereas pseudo-synthetic seismograms are constructed with a density log plus a resistivity, neutron, gamma ray, or rarely a spontaneous potential log. Herein, we introduce a new technique for constructing a pseudo-synthetic seismogram by combining the gamma ray (GR) and self-potential (SP) logs to produce the spontaneous ray (SR) log. Three wells, each of which consisted of more than 1000 m of carbonates, sandstones, and shales, were investigated; each well was divided into 12 Groups based on formation tops, and the Pearson product-moment correlation coefficient (PCC) was calculated for each "Group" from each of the GR, SP, and SR logs. The highest PCC-valued log curves for each Group were then combined to produce a single log whose values were cross-plotted against the reference well's sonic ITT values to determine a linear transform for producing a pseudo-sonic (PS) log and, ultimately, a pseudo-synthetic seismogram. The range for the Nash-Sutcliffe efficiency (NSE) acceptable value for the pseudo-sonic logs of three wells was 78-83%. This technique was tested on three wells, one of which was used as a blind test well, with satisfactory results. The PCC value between the composite PS (SR) log with low-density correction and the conventional sonic (CS) log was 86%. Because of the common occurrence of spontaneous potential and gamma ray logs in many of the hydrocarbon basins of the world, this inexpensive and straightforward technique could hold significant promise in areas that are in need of alternate ways to create pseudo-synthetic seismograms for seismic reflection interpretation.

Evaluation of the use of partition coefficients and molecular surface properties as predictors of drug absorption: a provisional biopharmaceutical classification of the list of national essential medicines of Pakistan

PubMed Central

Shawahna, R.; Rahman, NU.

2011-01-01

Background and the purpose of the study Partition coefficients (log D and log P) and molecular surface area (PSA) are potential predictors of the intestinal permeability of drugs. The aim of this investigation was to evaluate and compare these intestinal permeability indicators. Methods Aqueous solubility data were obtained from literature or calculated using ACD/Labs and ALOGPS. Permeability data were predicted based on log P, log D at pH 6.0 (log D6.0), and PSA. Results Metoprolol's log P, log D6.0, and a PSA of <65 Å correctly predicted 55.9%, 50.8% and 54.2% of permeability classes, respectively. Labetalol's log P, log D6.0 and PSA correctly predicted 54.2%, 64.4% and 61% of permeability classes, respectively. Log D6.0 correlated well (81%) with Caco-2 permeability (Papp). Of the list of national essential medicines, 135 orally administered drugs were classified into biopharmaceutical classification system (BCS). Of these, 57 (42.2%), 28 (20.7%), 44 (32.6%), and 6 (4.4%) were class I, II, III and IV respectively. Conclusion Log D6.0 showed better prediction capability than log P. Metoprolol as permeability internal standard was more conservative than labetalol. PMID:22615645

Multicriteria evaluation of simulated logging scenarios in a tropical rain forest.

PubMed

Huth, Andreas; Drechsler, Martin; Köhler, Peter

2004-07-01

Forest growth models are useful tools for investigating the long-term impacts of logging. In this paper, the results of the rain forest growth model FORMIND were assessed by a multicriteria decision analysis. The main processes covered by FORMIND include tree growth, mortality, regeneration and competition. Tree growth is calculated based on a carbon balance approach. Trees compete for light and space; dying large trees fall down and create gaps in the forest. Sixty-four different logging scenarios for an initially undisturbed forest stand at Deramakot (Malaysia) were simulated. The scenarios differ regarding the logging cycle, logging method, cutting limit and logging intensity. We characterise the impacts with four criteria describing the yield, canopy opening and changes in species composition. Multicriteria decision analysis was used for the first time to evaluate the scenarios and identify the efficient ones. Our results plainly show that reduced-impact logging scenarios are more 'efficient' than the others, since in these scenarios forest damage is minimised without significantly reducing yield. Nevertheless, there is a trade-off between yield and achieving a desired ecological state of logged forest; the ecological state of the logged forests can only be improved by reducing yields and enlarging the logging cycles. Our study also demonstrates that high cutting limits or low logging intensities cannot compensate for the high level of damage caused by conventional logging techniques.

When is hardwood cable logging economical?

Treesearch

Chris B. LeDoux

1985-01-01

Using cable logging to harvest eastern hardwood logs on steep terrain can result in low production rates and high costs per unit of wood produced. Logging managers can improve productivity and profitability by knowing how the interaction of site-specific variables and cable logging equipment affect costs and revenues. Data from selected field studies and forest model...

Performance of sampling methods to estimate log characteristics for wildlife.

Treesearch

Lisa J. Bate; Torolf R. Torgersen; Michael J. Wisdom; Edward O. Garton

2004-01-01

Accurate estimation of the characteristics of log resources, or coarse woody debris (CWD), is critical to effective management of wildlife and other forest resources. Despite the importance of logs as wildlife habitat, methods for sampling logs have traditionally focused on silvicultural and fire applications. These applications have emphasized estimates of log volume...

Logging utilization in Idaho: Current and past trends

Treesearch

Eric A. Simmons; Todd A. Morgan; Erik C. Berg; Stanley J. Zarnoch; Steven W. Hayes; Mike T. Thompson

2014-01-01

A study of commercial timber-harvesting activities in Idaho was conducted during 2008 and 2011 to characterize current tree utilization, logging operations, and changes from previous Idaho logging utilization studies. A two-stage simple random sampling design was used to select sites and felled trees for measurement within active logging sites. Thirty-three logging...

Stress wave sorting of red maple logs for structural quality

Treesearch

Xiping Wang; Robert J. Ross; David W. Green; Brian Brashaw; Karl Englund; Michael Wolcott

2004-01-01

Existing log grading procedures in the United States make only visual assessments of log quality. These procedures do not incorporate estimates of the modulus of elasticity (MOE) of logs. It is questionable whether the visual grading procedures currently used for logs adequately assess the potential quality of structural products manufactured from them, especially...

Nondestructive evaluation for sorting red maple logs

Treesearch

Xiping Wang; Robert J. Ross; David W. Green; Karl Englund; Michael Wolcott

2000-01-01

Existing log grading procedures in the United States make only visual assessments of log quality. These procedures do not incorporate estimates of the modulus of elasticity (MOE) of logs. It is questionable whether the visual grading procedures currently used for logs adequately assess the potential quality of structural products manufactured from them, especially...

Hardwood log supply: a broader perspective

Treesearch

Iris Montague; Adri Andersch; Jan Wiedenbeck; Urs Buehlmann

2015-01-01

At regional and state meetings we talk with others in our business about the problems we face: log exports, log quality, log markets, logger shortages, cash flow problems, the weather. These are familiar talking points and real and persistent problems. But what is the relative importance of these problems for log procurement in different regions of...

Hydrogeology of shallow basin-fill deposits in areas of Salt Lake Valley, Salt Lake County, Utah

USGS Publications Warehouse

Thiros, Susan A.

2003-01-01

A study of recently developed residential/commercial areas of Salt Lake Valley, Utah, was done from 1999 to 2001 in areas in which shallow ground water has the potential to move to a deeper aquifer that is used for public supply. Thirty monitoring wells were drilled and sampled in 1999 as part of the study. The ground water was either under unconfined or confined conditions, depending on depth to water and the presence or absence of fine-grained deposits. The wells were completed in the shallowest water-bearing zone capable of supplying water. Monitoring-well depths range from 23 to 154 feet. Lithologic, geophysical, hydraulic-conductivity, transmissivity, water-level, and water-temperature data were obtained for or collected from the wells.Silt and clay layers noted on lithologic logs correlate with increases in electrical conductivity and natural gamma radiation shown on many of the electromagnetic-induction and natural gamma logs. Relatively large increases in electrical conductivity, determined from the electromagnetic-induction logs, with no major changes in natural gamma radiation are likely caused by increased dissolved-solids content in the ground water. Some intervals with high electrical conductivity correspond to areas in which water was present during drilling.Unconfined conditions were present at 7 of 20 monitoring wells on the west side and at 2 of 10 wells on the east side of Salt Lake Valley. Fine-grained deposits confine the ground water. Anthropogenic compounds were detected in water sampled from most of the wells, indicating a connection with the land surface. Data were collected from 20 of the monitoring wells to estimate the hydraulic conductivity and transmissivity of the shallow ground-water system. Hydraulic-conductivity values of the shallow aquifer ranged from 30 to 540 feet per day. Transmissivity values of the shallow aquifer ranged from 3 to 1,070 feet squared per day. There is a close linear relation between transmissivity determined from slug-test analysis and transmissivity estimated from specific capacity.Water-level fluctuations were measured in the 30 monitoring wells from 1999 to July 2001. Generally, water-level changes measured in wells on the west side of the valley followed a seasonal trend and wells on the east side showed less fluctuation or a gradual decline during the 2-year period. This may indicate that a larger percentage of recharge to the shallow ground-water system on the west side is from somewhat consistent seasonal sources, such as canals and unconsumed irrigation water, as compared to sources on the east side. Water levels measured in monitoring wells completed in the shallow ground-water system near large-capacity public-supply wells varied in response to ground-water withdrawals from the deeper confined aquifer. Water temperature was monitored in 23 wells. Generally, little or no change in water temperature was measured in monitoring wells with a depth to water greater than about 40 feet. The shallower the water level in the well, the greater the water-temperature change measured during the study.Comparison of water levels measured in the monitoring wells and deeper wells in the same area indicate a downward gradient on the east side of the valley. Water levels in the shallow and deeper aquifers in the secondary recharge area on the west side of the valley were similar to those on the east side. Water levels measured in the monitoring wells and nearby wells completed in the deeper aquifer indicate that the vertical gradient can change with time and stresses on the system.

Logging disturbance shifts net primary productivity and its allocation in Bornean tropical forests.

PubMed

Riutta, Terhi; Malhi, Yadvinder; Kho, Lip Khoon; Marthews, Toby R; Huaraca Huasco, Walter; Khoo, MinSheng; Tan, Sylvester; Turner, Edgar; Reynolds, Glen; Both, Sabine; Burslem, David F R P; Teh, Yit Arn; Vairappan, Charles S; Majalap, Noreen; Ewers, Robert M

2018-01-24

Tropical forests play a major role in the carbon cycle of the terrestrial biosphere. Recent field studies have provided detailed descriptions of the carbon cycle of mature tropical forests, but logged or secondary forests have received much less attention. Here, we report the first measures of total net primary productivity (NPP) and its allocation along a disturbance gradient from old-growth forests to moderately and heavily logged forests in Malaysian Borneo. We measured the main NPP components (woody, fine root and canopy NPP) in old-growth (n = 6) and logged (n = 5) 1 ha forest plots. Overall, the total NPP did not differ between old-growth and logged forest (13.5 ± 0.5 and 15.7 ± 1.5 Mg C ha -1  year -1 respectively). However, logged forests allocated significantly higher fraction into woody NPP at the expense of the canopy NPP (42% and 48% into woody and canopy NPP, respectively, in old-growth forest vs 66% and 23% in logged forest). When controlling for local stand structure, NPP in logged forest stands was 41% higher, and woody NPP was 150% higher than in old-growth stands with similar basal area, but this was offset by structure effects (higher gap frequency and absence of large trees in logged forest). This pattern was not driven by species turnover: the average woody NPP of all species groups within logged forest (pioneers, nonpioneers, species unique to logged plots and species shared with old-growth plots) was similar. Hence, below a threshold of very heavy disturbance, logged forests can exhibit higher NPP and higher allocation to wood; such shifts in carbon cycling persist for decades after the logging event. Given that the majority of tropical forest biome has experienced some degree of logging, our results demonstrate that logging can cause substantial shifts in carbon production and allocation in tropical forests. © 2018 John Wiley & Sons Ltd.

Power law behavior of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction, and patients with heart transplants

NASA Technical Reports Server (NTRS)

Bigger, J. T. Jr; Steinman, R. C.; Rolnitzky, L. M.; Fleiss, J. L.; Albrecht, P.; Cohen, R. J.

1996-01-01

BACKGROUND. The purposes of the present study were (1) to establish normal values for the regression of log(power) on log(frequency) for, RR-interval fluctuations in healthy middle-aged persons, (2) to determine the effects of myocardial infarction on the regression of log(power) on log(frequency), (3) to determine the effect of cardiac denervation on the regression of log(power) on log(frequency), and (4) to assess the ability of power law regression parameters to predict death after myocardial infarction. METHODS AND RESULTS. We studied three groups: (1) 715 patients with recent myocardial infarction; (2) 274 healthy persons age and sex matched to the infarct sample; and (3) 19 patients with heart transplants. Twenty-four-hour RR-interval power spectra were computed using fast Fourier transforms and log(power) was regressed on log(frequency) between 10(-4) and 10(-2) Hz. There was a power law relation between log(power) and log(frequency). That is, the function described a descending straight line that had a slope of approximately -1 in healthy subjects. For the myocardial infarction group, the regression line for log(power) on log(frequency) was shifted downward and had a steeper negative slope (-1.15). The transplant (denervated) group showed a larger downward shift in the regression line and a much steeper negative slope (-2.08). The correlation between traditional power spectral bands and slope was weak, and that with log(power) at 10(-4) Hz was only moderate. Slope and log(power) at 10(-4) Hz were used to predict mortality and were compared with the predictive value of traditional power spectral bands. Slope and log(power) at 10(-4) Hz were excellent predictors of all-cause mortality or arrhythmic death. To optimize the prediction of death, we calculated a log(power) intercept that was uncorrelated with the slope of the power law regression line. We found that the combination of slope and zero-correlation log(power) was an outstanding predictor, with a relative risk of > 10, and was better than any combination of the traditional power spectral bands. The combination of slope and log(power) at 10(-4) Hz also was an excellent predictor of death after myocardial infarction. CONCLUSIONS. Myocardial infarction or denervation of the heart causes a steeper slope and decreased height of the power law regression relation between log(power) and log(frequency) of RR-interval fluctuations. Individually and, especially, combined, the power law regression parameters are excellent predictors of death of any cause or arrhythmic death and predict these outcomes better than the traditional power spectral bands.

Models of Compensation (MODCOMP): Policy Analyses and Unemployment Effects

DTIC Science & Technology

2008-08-01

423206 | | N = 11954 N0= 6895 N1= 5059 | | LogL = -7024.00448 LogL0 = -8144.3273 | | Estrella = 1-(L/L0)^(-2L0/n) = .18262...11954 N0= 6895 N1= 5059 | | LogL = -6808.94442 LogL0 = -8144.3273 | | Estrella = 1-(L/L0)^(-2L0/n) = .21653...11954 N0= 6895 N1= 5059 | | LogL = -6823.04000 LogL0 = -8144.3273 | | Estrella = 1-(L/L0)^(-2L0/n) = .21432

47 CFR 76.1706 - Signal leakage logs and repair records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the probable cause of the leakage. The log shall be kept on file for a period of two years and shall... 47 Telecommunication 4 2010-10-01 2010-10-01 false Signal leakage logs and repair records. 76.1706... leakage logs and repair records. Cable operators shall maintain a log showing the date and location of...

47 CFR 76.1706 - Signal leakage logs and repair records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the probable cause of the leakage. The log shall be kept on file for a period of two years and shall... 47 Telecommunication 4 2011-10-01 2011-10-01 false Signal leakage logs and repair records. 76.1706... leakage logs and repair records. Cable operators shall maintain a log showing the date and location of...

Veneer Log Production and Receipts in the Southeast, 1969

Treesearch

Richard L. Welch

1971-01-01

In 1969, production of veneer logs was almost 657 million board feet in the Southeast, while receipts of domestic logs at the 136 mills in the area were over 690 million board feet. Pine log production now amounts to 40 percent of the total, while hardwood log production is down 17 percent from that of 1963.

Designing and Piloting a Leadership Daily Practice Log: Using Logs to Study the Practice of Leadership

ERIC Educational Resources Information Center

Spillane, James P.; Zuberi, Anita

2009-01-01

Purpose: This article aims to validate the Leadership Daily Practice (LDP) log, an instrument for conducting research on leadership in schools. Research Design: Using a combination of data sources--namely, a daily practice log, observations, and open-ended cognitive interviews--the authors evaluate the validity of the LDP log. Participants: Formal…

The Value of Web Log Data in Use-based Design and Testing.

ERIC Educational Resources Information Center

Burton, Mary C.; Walther, Joseph B.

2001-01-01

Suggests Web-based logs contain useful empirical data with which World Wide Web designers and design theorists can assess usability and effectiveness of design choices. Enumerates identification of types of Web server logs, client logs, types and uses of log data, and issues associated with the validity of these data. Presents an approach to…

Using Web Server Logs in Evaluating Instructional Web Sites.

ERIC Educational Resources Information Center

Ingram, Albert L.

2000-01-01

Web server logs contain a great deal of information about who uses a Web site and how they use it. This article discusses the analysis of Web logs for instructional Web sites; reviews the data stored in most Web server logs; demonstrates what further information can be gleaned from the logs; and discusses analyzing that information for the…

32 CFR 700.845 - Maintenance of logs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be...

32 CFR 700.845 - Maintenance of logs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be...

32 CFR 700.845 - Maintenance of logs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be...

32 CFR 700.845 - Maintenance of logs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be...

32 CFR 700.845 - Maintenance of logs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS The Commanding Officer Commanding Officers Afloat § 700.845 Maintenance of logs. (a) A deck log and an engineering log shall be...

Automated lithology prediction from PGNAA and other geophysical logs.

PubMed

Borsaru, M; Zhou, B; Aizawa, T; Karashima, H; Hashimoto, T

2006-02-01

Different methods of lithology predictions from geophysical data have been developed in the last 15 years. The geophysical logs used for predicting lithology are the conventional logs: sonic, neutron-neutron, gamma (total natural-gamma) and density (backscattered gamma-gamma). The prompt gamma neutron activation analysis (PGNAA) is another established geophysical logging technique for in situ element analysis of rocks in boreholes. The work described in this paper was carried out to investigate the application of PGNAA to the lithology interpretation. The data interpretation was conducted using the automatic interpretation program LogTrans based on statistical analysis. Limited test suggests that PGNAA logging data can be used to predict the lithology. A success rate of 73% for lithology prediction was achieved from PGNAA logging data only. It can also be used in conjunction with the conventional geophysical logs to enhance the lithology prediction.

Optimal Search for Moving Targets in Continuous Time and Space using Consistent Approximations

DTIC Science & Technology

2011-09-01

σnNµ )q/ν M q = κ b −n log c̄ log b +B1B2 + K( b σnNµ )q/ν ( b σnNµ )q/ν M q = B2 [ κ B2b −n log c̄ log b +B1 + ( b σnNµ )q/ν B2M q Kσq/νnq/νNµq/ν bq/ν...IV.52) Since −nb log c̄ log b → a1 ∈ [ pq µq + νp ,∞), 106 the expression κ B2b −n log c̄ log b (IV.53) goes to 0, as b→∞. In addition, we know...Burden, R. (1993). Numerical methods. Boston, Massachusetts: PWS Publishing Company . Ghabcheloo, R., Kaminer, I., Aguiar, A., & Pascoal, A. (2009). A

LogScope

NASA Technical Reports Server (NTRS)

Havelund, Klaus; Smith, Margaret H.; Barringer, Howard; Groce, Alex

2012-01-01

LogScope is a software package for analyzing log files. The intended use is for offline post-processing of such logs, after the execution of the system under test. LogScope can, however, in principle, also be used to monitor systems online during their execution. Logs are checked against requirements formulated as monitors expressed in a rule-based specification language. This language has similarities to a state machine language, but is more expressive, for example, in its handling of data parameters. The specification language is user friendly, simple, and yet expressive enough for many practical scenarios. The LogScope software was initially developed to specifically assist in testing JPL s Mars Science Laboratory (MSL) flight software, but it is very generic in nature and can be applied to any application that produces some form of logging information (which almost any software does).

1. Photocopy of undated wash drawing. The largest building is ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of undated wash drawing. The largest building is the Hotel Williams. Next to it is the Williams House (Williams Hotel Annex), HABS No. MI-258 A. Below them are the log cabins built by the American Fur Company (from left to right): Log Building No. 1 (MI-258 C), Log Building No. 2 (MI-258 D), Log Building No. 3 (not documented), Log Building No. 4 (MI-258 E), and Log Building No. 5 (MI-258 F). (Williams Log House, MI-258 B, and Log Building No. 8, MI-258 G, are not shown). The drawing is in the collection of the Michigan Historical Commission. Although it does not have a date, it was painted in the early 20th century after the main building was constructed. - Hotel Williams, Murray Bay, Munising, Alger County, MI

Fire Impact on Surface Fuels and Carbon Emissions in Scots pine Logged Sites of Siberia

NASA Astrophysics Data System (ADS)

Ivanova, G. A.; Kukavskaya, E. A.; Bogorodskaya, A. V.; Ivanov, V. A.; Zhila, S. V.; Conard, S. G.

2012-04-01

Forest fire and large-scale forest harvesting are the two major disturbances in the Russian boreal forests. Non-recovered logged sites total about a million hectares. Logged sites are characterized by higher fire hazard than forest sites due great amounts of logging slash, which dries out much more rapidly compared to understory fuels. Moreover, most logging sites can be easily accessed by local population. Both legal and illegal logging are also increasing rapidly in many forest areas of Siberia. Fire effects on forest overstory, subcanopy woody layer, and ground vegetation biomass were estimated on logged vs. unlogged sites in the Central Siberia region in 2009-2012 as a part of the project "The Influence of Changing Forestry Practices on the Effects of Wildfire and on Interactions Between Fire and Changing Climate in Central Siberia" supported by NASA (NEESPI). Dead down woody fuels are significantly less at unburned/logged area of dry southern regions compared to more humid northern regions. Fuel consumption was typically less in spring fires than during summer fires. Fire-caused carbon emissions on logged sites appeared to be twice that on unlogged sites. Soil respiration is less at logged areas compared to undisturbed forest. After fire soil respiration decreases both at logged and unlogged areas. arbon emissions from fire and post-fire ecosystem damage on logged sites are expected to increase under changing climate conditions and as a result of anticipated increases in future forest harvesting in Siberia.

Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood-Brain Barrier Permeation of Drugs.

PubMed

Grumetto, Lucia; Russo, Giacomo; Barbato, Francesco

2016-08-01

The affinity indexes for phospholipids (log kW(IAM)) for 42 compounds were measured by high performance liquid chromatography (HPLC) on two different phospholipid-based stationary phases (immobilized artificial membrane, IAM), i.e., IAM.PC.MG and IAM.PC.DD2. The polar/electrostatic interaction forces between analytes and membrane phospholipids (Δlog kW(IAM)) were calculated as the differences between the experimental values of log kW(IAM) and those expected for isolipophilic neutral compounds having polar surface area (PSA) = 0. The values of passage through a porcine brain lipid extract (PBLE) artificial membrane for 36 out of the 42 compounds considered, measured by the so-called PAMPA-BBB technique, were taken from the literature (P0(PAMPA-BBB)). The values of blood-brain barrier (BBB) passage measured in situ, P0(in situ), for 38 out of the 42 compounds considered, taken from the literature, represented the permeability of the neutral forms on "efflux minimized" rodent models. The present work was aimed at verifying the soundness of Δlog kW(IAM) at describing the potential of passage through the BBB as compared to data achieved by the PAMPA-BBB technique. In a first instance, the values of log P0(PAMPA-BBB) (32 data points) were found significantly related to the n-octanol lipophilicity values of the neutral forms (log P(N)) (r(2) = 0.782) whereas no significant relationship (r(2) = 0.246) was found with lipophilicity values of the mixtures of ionized and neutral forms existing at the experimental pH 7.4 (log D(7.4)) as well as with either log kW(IAM) or Δlog kW(IAM) values. log P0(PAMPA-BBB) related moderately to log P0(in situ) values (r(2) = 0.604). The latter did not relate with either n-octanol lipophilicity indexes (log P(N) and log D(7.4)) or phospholipid affinity indexes (log kW(IAM)). In contrast, significant inverse linear relationships were observed between log P0(in situ) (38 data points) and Δlog kW(IAM) values for all the compounds but ibuprofen and chlorpromazine, which behaved as moderate outliers (r(2) = 0.656 and r(2) = 0.757 for values achieved on IAM.PC.MG and IAM.PC.DD2, respectively). Since log P0(in situ) refer to the "intrinsic permeability" of the analytes regardless their ionization degree, no correction for ionization of Δlog kW(IAM) values was needed. Furthermore, log P0(in situ) were found roughly linearly related to log BB values (i.e., the logarithm of the ratio brain concentration/blood concentration measured in vivo) for all the analytes but those predominantly present at the experimental pH 7.4 as anions. These results suggest that, at least for the data set considered, Δlog kW(IAM) parameters are more effective than log P0(PAMPA-BBB) at predicting log P0(in situ) values for all the analytes. Furthermore, ionization appears to affect differently, and much more markedly, BBB passage of acids (yielding anions) than that of the other ionizable compounds.

Maternal body burden of cadmium and offspring size at birth

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romano, Megan E., E-mail: megan_romano@brown.edu; Enquobahrie, Daniel A.; Center for Perinatal Studies, Swedish Medical Center, Seattle, WA

Increasing evidence suggests an inverse association between cadmium (Cd) and size at birth, potentially greatest among female neonates. We evaluated whether greater maternal body burden of Cd is associated with reduced neonatal anthropometry (birthweight, birth length, head circumference, and ponderal index) and assessed whether these associations differ by infant sex. The analytic sample for the present study (n=396) was derived from a subcohort of 750 women randomly drawn from among all participants (N=4344) in the Omega Study, a prospective pregnancy cohort. Creatinine-corrected Cd in maternal clean-catch spot urine samples (U-Cd) was quantified by inductively coupled plasma mass spectrometry. Continuous log{submore » 2}-transformed Cd (log{sub 2}-Cd) and U-Cd tertiles (low<0.29 μg/g creatinine, middle 0.29–0.42 μg/g creatinine, high≥0.43 μg/g creatinine) were used in multivariable linear regression models. Females had reduced birth length with greater U-Cd tertile, whereas males birth length marginally increased [β(95% CI) females: low=reference, middle=−0.59 cm (−1.37, 0.19), high=−0.83 cm (−1.69, 0.02), p-trend=0.08; males: low=reference, middle=0.18 cm (−0.59, 0.95), high=0.78 cm (–0.04, 1.60), p-trend=0.07; p for interaction=0.03]. The log{sub 2}-Cd by infant sex interaction was statistically significant for ponderal index [p=0.003; β(95% CI): female=0.25 kg/m{sup 3} (−0.20, 0.70); male=−0.63 kg/m{sup 3} (−1.01, −0.24)] and birth length [p<0.001; β(95% CI): female=−0.47 cm (−0.74, −0.20), male=0.32 cm (0.00, 0.65)]. Our findings suggest potential sex-specific reversal of Cd’s associations on birth length and contribute to the evidence suggesting Cd impairs fetal growth. - Highlights: • Cadmium levels in the general population potentially adversely affect size at birth. • Maternal urinary cadmium was inversely related to birth length among female infants. • For male infants, maternal cadmium was positively associated with birth length. • Maternal cadmium was also inversely related to ponderal index among male infants.« less

Veneer-log production and receipts in the Southeast, 1988

Treesearch

Cecil C. Hutchins

1990-01-01

In 1988, almost 1.4 billion board feet of veneer logs were harvested in the Southeast, and the region's veneer mills processed approximately 1.5 billion board feet of logs. Almost 78 percent of veneer-log production and 76 percent of veneer-log receipts were softwood. There were 79 veneer mills operating in 1988. Softwood plywood was the major product. Almost all...

Methodology for locating defects within hardwood logs and determining their impact on lumber-value yield

Treesearch

Thomas Harless; Francis G. Wagner; Phillip Steele; Fred Taylor; Vikram Yadama; Charles W. McMillin

1991-01-01

A precise research methodology is described by which internal log-defect locations may help select hardwood log ortentation and sawing procedure to improve lumber value. Procedures for data collection, data handling, simulated sawing, and data analysis are described. A single test log verified the methodology. Results from this log showed significant differences in...

A method of estimating log weights.

Treesearch

Charles N. Mann; Hilton H. Lysons

1972-01-01

This paper presents a practical method of estimating the weights of logs before they are yarded. Knowledge of log weights is required to achieve optimum loading of modern yarding equipment. Truckloads of logs are weighed and measured to obtain a local density index (pounds per cubic foot) for a species of logs. The density index is then used to estimate the weights of...

1. GENERAL VIEW OF LOG POND AND BOOM FOR UNLOADING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF LOG POND AND BOOM FOR UNLOADING CEDAR LOGS FROM TRUCKS AT LOG DUMP, ADJACENT TO MILL; TRUCKS FORMERLY USED TRIP STAKES, THOUGH FOR SAFER HANDLING OF LOGS WELDED STAKES ARE NOW REQUIRED; AS A RESULT LOADING IS NOW DONE WITH A CRANE - Lester Shingle Mill, 1602 North Eighteenth Street, Sweet Home, Linn County, OR

75 FR 75995 - Request for Comments on Helium-3 Use in the Oil and Natural Gas Well Logging Industry

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... manufacture neutron detectors used by the well logging industry or wireline or Logging-While-Drilling tools incorporating neutron detectors, and whether companies purchase or lease logging tools that contain neutron detectors. DOE also seeks information on the volumes of Helium-3 anticipated by the oil and gas well logging...

Lumber yield and log values of Shasta red fir.

Treesearch

John B. Grantham; Douglas L. Hunt

1963-01-01

The value of lumber produced from each of 362 Shasta red fir logs of southern Oregon was determined through a cooperative study in 1960. Lumber grade yield from each log provided the basis for calculating the comparative value of each log grade-log diameter class, in accordance with grading and scaling practices used both east and west of the...

Effects of postfire salvage logging on deadwood-associated beetles.

PubMed

Cobb, T P; Morissette, J L; Jacobs, J M; Koivula, M J; Spence, J R; Langor, D W

2011-02-01

In Canada and the United States pressure to recoup financial costs of wildfire by harvesting burned timber is increasing, despite insufficient understanding of the ecological consequences of postfire salvage logging. We compared the species richness and composition of deadwood-associated beetle assemblages among undisturbed, recently burned, logged, and salvage-logged, boreal, mixed-wood stands. Species richness was lowest in salvage-logged stands, largely due to a negative effect of harvesting on the occurrence of wood- and bark-boring species. In comparison with undisturbed stands, the combination of wildfire and logging in salvage-logged stands had a greater effect on species composition than either disturbance alone. Strong differences in species composition among stand treatments were linked to differences in quantity and quality (e.g., decay stage) of coarse woody debris. We found that the effects of wildfire and logging on deadwood-associated beetles were synergistic, such that the effects of postfire salvage logging could not be predicted reliably on the basis of data on either disturbance alone. Thus, increases in salvage logging of burned forests may have serious negative consequences for deadwood-associated beetles and their ecological functions in early postfire successional forests. ©2010 Society for Conservation Biology.

Logging impacts on avian species richness and composition differ across latitudes relative to foraging and breeding habitat preferences

USGS Publications Warehouse

LaManna, Joseph A.; Martin, Thomas E.

2017-01-01

Understanding the causes underlying changes in species diversity is a fundamental pursuit of ecology. Animal species richness and composition often change with decreased forest structural complexity associated with logging. Yet differences in latitude and forest type may strongly influence how species diversity responds to logging. We performed a meta-analysis of logging effects on local species richness and composition of birds across the world and assessed responses by different guilds (nesting strata, foraging strata, diet, and body size). This approach allowed identification of species attributes that might underlie responses to this anthropogenic disturbance. We only examined studies that allowed forests to regrow naturally following logging, and accounted for logging intensity, spatial extent, successional regrowth after logging, and the change in species composition expected due to random assembly from regional species pools. Selective logging in the tropics and clearcut logging in temperate latitudes caused loss of species from nearly all forest strata (ground to canopy), leading to substantial declines in species richness (up to 27% of species). Few species were lost or gained following any intensity of logging in lower-latitude temperate forests, but the relative abundances of these species changed substantially. Selective logging at higher-temperate latitudes generally replaced late-successional specialists with early-successional specialists, leading to no net changes in species richness but large changes in species composition. Removing less basal area during logging mitigated the loss of avian species from all forests and, in some cases, increased diversity in temperate forests. This meta-analysis provides insights into the important role of habitat specialization in determining differential responses of animal communities to logging across tropical and temperate latitudes.

Efficient Merge and Insert Operations for Binary Heaps and Trees

NASA Technical Reports Server (NTRS)

Kuszmaul, Christopher Lee; Woo, Alex C. (Technical Monitor)

2000-01-01

Binary heaps and binary search trees merge efficiently. We introduce a new amortized analysis that allows us to prove the cost of merging either binary heaps or balanced binary trees is O(l), in the amortized sense. The standard set of other operations (create, insert, delete, extract minimum, in the case of binary heaps, and balanced binary trees, as well as a search operation for balanced binary trees) remain with a cost of O(log n). For binary heaps implemented as arrays, we show a new merge algorithm that has a single operation cost for merging two heaps, a and b, of O(absolute value of a + min(log absolute value of b log log absolute value of b. log absolute value of a log absolute value of b). This is an improvement over O(absolute value of a + log absolute value of a log absolute value of b). The cost of the new merge is so low that it can be used in a new structure which we call shadow heaps. to implement the insert operation to a tunable efficiency. Shadow heaps support the insert operation for simple priority queues in an amortized time of O(f(n)) and other operations in time O((log n log log n)/f (n)), where 1 less than or equal to f (n) less than or equal to log log n. More generally, the results here show that any data structure with operations that change its size by at most one, with the exception of a merge (aka meld) operation, can efficiently amortize the cost of the merge under conditions that are true for most implementations of binary heaps and search trees.

Logging impacts on avian species richness and composition differ across latitudes and foraging and breeding habitat preferences.

PubMed

LaManna, Joseph A; Martin, Thomas E

2017-08-01

Understanding the causes underlying changes in species diversity is a fundamental pursuit of ecology. Animal species richness and composition often change with decreased forest structural complexity associated with logging. Yet differences in latitude and forest type may strongly influence how species diversity responds to logging. We performed a meta-analysis of logging effects on local species richness and composition of birds across the world and assessed responses by different guilds (nesting strata, foraging strata, diet, and body size). This approach allowed identification of species attributes that might underlie responses to this anthropogenic disturbance. We only examined studies that allowed forests to regrow naturally following logging, and accounted for logging intensity, spatial extent, successional regrowth after logging, and the change in species composition expected due to random assembly from regional species pools. Selective logging in the tropics and clearcut logging in temperate latitudes caused loss of species from nearly all forest strata (ground to canopy), leading to substantial declines in species richness (up to 27% of species). Few species were lost or gained following any intensity of logging in lower-latitude temperate forests, but the relative abundances of these species changed substantially. Selective logging at higher-temperate latitudes generally replaced late-successional specialists with early-successional specialists, leading to no net changes in species richness but large changes in species composition. Removing less basal area during logging mitigated the loss of avian species from all forests and, in some cases, increased diversity in temperate forests. This meta-analysis provides insights into the important role of habitat specialization in determining differential responses of animal communities to logging across tropical and temperate latitudes. © 2016 Cambridge Philosophical Society.

Fracture Modes and Identification of Fault Zones in Wenchuan Earthquake Fault Scientific Drilling Boreholes

NASA Astrophysics Data System (ADS)

Deng, C.; Pan, H.; Zhao, P.; Qin, R.; Peng, L.

2017-12-01

After suffering from the disaster of Wenchuan earthquake on May 12th, 2008, scientists are eager to figure out the structure of formation, the geodynamic processes of faults and the mechanism of earthquake in Wenchuan by drilling five holes into the Yingxiu-Beichuan fault zone and Anxian-Guanxian fault zone. Fractures identification and in-situ stress determination can provide abundant information for formation evaluation and earthquake study. This study describe all the fracture modes in the five boreholes on the basis of cores and image logs, and summarize the response characteristics of fractures in conventional logs. The results indicate that the WFSD boreholes encounter enormous fractures, including natural fractures and induced fractures, and high dip-angle conductive fractures are the most common fractures. The maximum horizontal stress trends along the borehole are deduced as NWW-SEE according to orientations of borehole breakouts and drilling-induced fractures, which is nearly parallel to the strikes of the younger natural fracture sets. Minor positive deviations of AC (acoustic log) and negative deviation of DEN (density log) demonstrate their responses to fracture, followed by CNL (neutron log), resistivity logs and GR (gamma ray log) at different extent of intensity. Besides, considering the fact that the reliable methods for identifying fracture zone, like seismic, core recovery and image logs, can often be hampered by their high cost and limited application, this study propose a method by using conventional logs, which are low-cost and available in even old wells. We employ wavelet decomposition to extract the high frequency information of conventional logs and reconstruction a new log in special format of enhance fracture responses and eliminate nonfracture influence. Results reveal that the new log shows obvious deviations in fault zones, which confirm the potential of conventional logs in fracture zone identification.

Evaluation of residual oil saturation after waterflood in a carbonate reservoir

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verma, M.K.; Boucherit, M.; Bouvier, L.

Four different approaches, including special core analysis (SCAL), log-inject-log, thermal-decay-time (TDT) logs, and material balance, were used to narrow the range of residual oil saturation (ROS) after waterflood, S[sub orw], in a carbonate reservoir in Qatar to between 23% and 27%. An equation was developed that relates S[sub orw] with connate-water saturation, S[sub wi], and porosity. This paper presents the results of S[sub orw] determinations with four different techniques: core waterflood followed by centrifuging, log-inject-log, TDT logging, and material balance.

Linear Equations with the Euler Totient Function

DTIC Science & Technology

2007-02-13

unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2 FLORIAN LUCA, PANTELIMON STĂNICĂ...of positive integers n such that φ(n) = φ(n+ 1), and that the set of Phibonacci numbers is A(1,1,−1) + 2. Theorem 2.1. Let C (t, a) = t3 logH(a). Then...the estimate #Aa(x) C (t, a) x log log log x√ log log x LINEAR EQUATIONS WITH THE EULER TOTIENT FUNCTION 3 holds uniformly in a and 1 ≤ t < y. Note

Variability in Accreditation Council for Graduate Medical Education Resident Case Log System practices among orthopaedic surgery residents.

PubMed

Salazar, Dane; Schiff, Adam; Mitchell, Erika; Hopkinson, William

2014-02-05

The Accreditation Council for Graduate Medical Education (ACGME) Resident Case Log System is designed to be a reflection of residents' operative volume and an objective measure of their surgical experience. All operative procedures and manipulations in the operating room, Emergency Department, and outpatient clinic are to be logged into the Resident Case Log System. Discrepancies in the log volumes between residents and residency programs often prompt scrutiny. However, it remains unclear if such disparities truly represent differences in operative experiences or if they are reflections of inconsistent logging practices. The purpose of this study was to investigate individual recording practices among orthopaedic surgery residents prior to August 1, 2011. Orthopaedic surgery residents received a questionnaire on case log practices that was distributed through the Council of Orthopaedic Residency Directors list server. Respondents were asked to respond anonymously about recording practices in different clinical settings as well as types of cases routinely logged. Hypothetical scenarios of common orthopaedic procedures were presented to investigate the differences in the Current Procedural Terminology codes utilized. Two hundred and ninety-eight orthopaedic surgery residents completed the questionnaire; 37% were fifth-year residents, 22% were fourth-year residents, 18% were third-year residents, 15% were second-year residents, and 8% were first-year residents. Fifty-six percent of respondents reported routinely logging procedures performed in the Emergency Department or urgent care setting. Twenty-two percent of participants routinely logged procedures in the clinic or outpatient setting, 20% logged joint injections, and only 13% logged casts or splints applied in the office setting. There was substantial variability in the Current Procedural Terminology codes selected for the seven clinical scenarios. There has been a lack of standardization in case-logging practices among orthopaedic surgery residents prior to August 1, 2011. ACGME case log data prior to this date may not be a reliable measure of residents' procedural experience.

Integrated analysis of well logs and seismic data to estimate gas hydrate concentrations at Keathley Canyon, Gulf of Mexico

USGS Publications Warehouse

Lee, M.W.; Collett, T.S.

2008-01-01

Accurately detecting and quantifying gas hydrate or free gas in sediments from seismic data require downhole well-log data to calibrate the physical properties of the gas hydrate-/free gas-bearing sediments. As part of the Gulf of Mexico Joint Industry Program, a series of wells were either cored or drilled in the Gulf of Mexico to characterize the physical properties of gas hydrate-bearing sediments, to calibrate geophysical estimates, and to evaluate source and transport mechanisms for gas within the gas hydrates. Downhole acoustic logs were used sparingly in this study because of degraded log quality due to adverse wellbore conditions. However, reliable logging while drilling (LWD) electrical resistivity and porosity logs were obtained. To tie the well-log information to the available 3-D seismic data in this area, a velocity log was calculated from the available resistivity log at the Keathley Canyon 151-2 well, because the acoustic log or vertical seismic data acquired at the nearby Keathley Canyon 151-3 well were either of poor quality or had limited depth coverage. Based on the gas hydrate saturations estimated from the LWD resistivity log, the modified Biot-Gassmann theory was used to generate synthetic acoustic log and a synthetic seismogram was generated with a fairly good agreement with a seismic profile crossing the well site. Based on the well-log information, a faintly defined bottom-simulating reflection (BSR) in this area is interpreted as a reflection representing gas hydrate-bearing sediments with about 15% saturation overlying partially gas-saturated sediments with 3% saturation. Gas hydrate saturations over 30-40% are estimated from the resistivity log in two distinct intervals at 220-230 and 264-300 m below the sea floor, but gas hydrate was not physically recovered in cores. It is speculated that the poor recovery of cores and gas hydrate morphology are responsible for the lack of physical gas hydrate recovery.

Fatigue shifts and scatters heart rate variability in elite endurance athletes.

PubMed

Schmitt, Laurent; Regnard, Jacques; Desmarets, Maxime; Mauny, Fréderic; Mourot, Laurent; Fouillot, Jean-Pierre; Coulmy, Nicolas; Millet, Grégoire

2013-01-01

This longitudinal study aimed at comparing heart rate variability (HRV) in elite athletes identified either in 'fatigue' or in 'no-fatigue' state in 'real life' conditions. 57 elite Nordic-skiers were surveyed over 4 years. R-R intervals were recorded supine (SU) and standing (ST). A fatigue state was quoted with a validated questionnaire. A multilevel linear regression model was used to analyze relationships between heart rate (HR) and HRV descriptors [total spectral power (TP), power in low (LF) and high frequency (HF) ranges expressed in ms(2) and normalized units (nu)] and the status without and with fatigue. The variables not distributed normally were transformed by taking their common logarithm (log10). 172 trials were identified as in a 'fatigue' and 891 as in 'no-fatigue' state. All supine HR and HRV parameters (Beta±SE) were significantly different (P<0.0001) between 'fatigue' and 'no-fatigue': HRSU (+6.27±0.61 bpm), logTPSU (-0.36±0.04), logLFSU (-0.27±0.04), logHFSU (-0.46±0.05), logLF/HFSU (+0.19±0.03), HFSU(nu) (-9.55±1.33). Differences were also significant (P<0.0001) in standing: HRST (+8.83±0.89), logTPST (-0.28±0.03), logLFST (-0.29±0.03), logHFST (-0.32±0.04). Also, intra-individual variance of HRV parameters was larger (P<0.05) in the 'fatigue' state (logTPSU: 0.26 vs. 0.07, logLFSU: 0.28 vs. 0.11, logHFSU: 0.32 vs. 0.08, logTPST: 0.13 vs. 0.07, logLFST: 0.16 vs. 0.07, logHFST: 0.25 vs. 0.14). HRV was significantly lower in 'fatigue' vs. 'no-fatigue' but accompanied with larger intra-individual variance of HRV parameters in 'fatigue'. The broader intra-individual variance of HRV parameters might encompass different changes from no-fatigue state, possibly reflecting different fatigue-induced alterations of HRV pattern.

Inactivation of Heat Adapted and Chlorine Adapted Listeria Monocytogenes ATCC 7644 on Tomatoes Using Sodium Dodecyl Sulphate, Levulinic Acid and Sodium Hypochlorite Solution.

PubMed

Ijabadeniyi, Oluwatosin Ademola; Mnyandu, Elizabeth

2017-04-13

The effectiveness of sodium dodecyl sulphate (SDS), sodium hypochlorite solution and levulinic acid in reducing the survival of heat adapted and chlorine adapted Listeria monocytogenes ATCC 7644 was evaluated. The results against heat adapted L. monocytognes revealed that sodium hypochlorite solution was the least effective, achieving log reduction of 2.75, 2.94 and 3.97 log colony forming unit (CFU)/mL for 1, 3 and 5 minutes, respectively. SDS was able to achieve 8 log reduction for both heat adapted and chlorine adapted bacteria. When used against chlorine adapted L. monocytogenes sodium hypochlorite solution achieved log reduction of 2.76, 2.93 and 3.65 log CFU/mL for 1, 3 and 5 minutes, respectively. Using levulinic acid on heat adapted bacteria achieved log reduction of 3.07, 2.78 and 4.97 log CFU/mL for 1, 3, 5 minutes, respectively. On chlorine adapted bacteria levulinic acid achieved log reduction of 2.77, 3.07 and 5.21 log CFU/mL for 1, 3 and 5 minutes, respectively. Using a mixture of 0.05% SDS and 0.5% levulinic acid on heat adapted bacteria achieved log reduction of 3.13, 3.32 and 4.79 log CFU/mL for 1, 3 and 5 minutes while on chlorine adapted bacteria it achieved 3.20, 3.33 and 5.66 log CFU/mL, respectively. Increasing contact time also increased log reduction for both test pathogens. A storage period of up to 72 hours resulted in progressive log reduction for both test pathogens. Results also revealed that there was a significant difference (P≤0.05) among contact times, storage times and sanitizers. Findings from this study can be used to select suitable sanitizers and contact times for heat and chlorine adapted L. monocytogenes in the fresh produce industry.

Induction of Virulence Gene Expression in Staphylococcus aureus by Pulmonary Surfactant

PubMed Central

Ishii, Kenichi; Adachi, Tatsuo; Yasukawa, Jyunichiro; Suzuki, Yutaka; Hamamoto, Hiroshi

2014-01-01

We performed a genomewide analysis using a next-generation sequencer to investigate the effect of pulmonary surfactant on gene expression in Staphylococcus aureus, a clinically important opportunistic pathogen. RNA sequence (RNA-seq) analysis of bacterial transcripts at late log phase revealed 142 genes that were upregulated >2-fold following the addition of pulmonary surfactant to the culture medium. Among these genes, we confirmed by quantitative reverse transcription-PCR analysis that mRNA amounts for genes encoding ESAT-6 secretion system C (EssC), an unknown hypothetical protein (NWMN_0246; also called pulmonary surfactant-inducible factor A [PsiA] in this study), and hemolysin gamma subunit B (HlgB) were increased 3- to 10-fold by the surfactant treatment. Among the major constituents of pulmonary surfactant, i.e., phospholipids and palmitate, only palmitate, which is the most abundant fatty acid in the pulmonary surfactant and a known antibacterial substance, stimulated the expression of these three genes. Moreover, these genes were also induced by supplementing the culture with detergents. The induction of gene expression by surfactant or palmitate was not observed in a disruption mutant of the sigB gene, which encodes an alternative sigma factor involved in bacterial stress responses. Furthermore, each disruption mutant of the essC, psiA, and hlgB genes showed attenuation of both survival in the lung and host-killing ability in a murine pneumonia model. These findings suggest that S. aureus resists membrane stress caused by free fatty acids present in the pulmonary surfactant through the regulation of virulence gene expression, which contributes to its pathogenesis within the lungs of the host animal. PMID:24452679

A high-throughput quantitative expression analysis of cancer-related genes in human HepG2 cells in response to limonene, a potential anticancer agent.

PubMed

Hafidh, Rand R; Hussein, Saba Z; MalAllah, Mohammed Q; Abdulamir, Ahmed S; Abu Bakar, Fatimah

2017-11-14

Citrus bioactive compounds, as active anticancer agent, have been under focus by several studies worldwide. However, the underlying genes responsible for the anticancer potential have not been sufficiently highlighted. The current study investigated the gene expression profile of hepatocellular carcinoma, HepG2, cells after treatment with Limonene. The concentration that killed 50% of HepG2 cells was used to elucidate the genetic mechanisms of limonene anticancer activity. The apoptotic induction was detected by flow cytometry and confocal fluorescence microscope. Two of pro-apoptotic events, caspase-3 activation and phosphatidylserine translocation were manifested by confocal fluorescence microscopy. High-throughput real-time PCR was used to profile 1023 cancer-related genes in 16 different gene families related to the cancer development. In comparison to untreated cells, limonene increased the percentage of apoptotic cells up to 89.61%, by flow cytometry, and 48.2% by fluorescence microscopy. There was a significant limonene-driven differential gene expression of HepG2 cells in 15 different gene families. Limonene was shown to significantly (>2log) up-regulate and down-regulate 14 and 59 genes, respectively. The affected gene families, from most to least affected, were apoptosis induction, signal transduction, cancer genes augmentation, alteration in kinases expression, inflammation, DNA damage repair, and cell cycle proteins. The current study reveals that limonene could be a promising, cheap, and effective anticancer compound. The broad spectrum of limonene anticancer activity is interesting for anticancer drug development. Further research is needed to confirm the current findings and to examine the anticancer potential of limonene along with underlying mechanisms on different cell lines. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Competitive fitness during feast and famine: how SOS DNA polymerases influence physiology and evolution in Escherichia coli.

PubMed

Corzett, Christopher H; Goodman, Myron F; Finkel, Steven E

2013-06-01

Escherichia coli DNA polymerases (Pol) II, IV, and V serve dual roles by facilitating efficient translesion DNA synthesis while simultaneously introducing genetic variation that can promote adaptive evolution. Here we show that these alternative polymerases are induced as cells transition from exponential to long-term stationary-phase growth in the absence of induction of the SOS regulon by external agents that damage DNA. By monitoring the relative fitness of isogenic mutant strains expressing only one alternative polymerase over time, spanning hours to weeks, we establish distinct growth phase-dependent hierarchies of polymerase mutant strain competitiveness. Pol II confers a significant physiological advantage by facilitating efficient replication and creating genetic diversity during periods of rapid growth. Pol IV and Pol V make the largest contributions to evolutionary fitness during long-term stationary phase. Consistent with their roles providing both a physiological and an adaptive advantage during stationary phase, the expression patterns of all three SOS polymerases change during the transition from log phase to long-term stationary phase. Compared to the alternative polymerases, Pol III transcription dominates during mid-exponential phase; however, its abundance decreases to <20% during long-term stationary phase. Pol IV transcription dominates as cells transition out of exponential phase into stationary phase and a burst of Pol V transcription is observed as cells transition from death phase to long-term stationary phase. These changes in alternative DNA polymerase transcription occur in the absence of SOS induction by exogenous agents and indicate that cell populations require appropriate expression of all three alternative DNA polymerases during exponential, stationary, and long-term stationary phases to attain optimal fitness and undergo adaptive evolution.

Methotrexate versus cyclophosphamide for remission maintenance in ANCA-associated vasculitis: A randomised trial.

PubMed

Maritati, Federica; Alberici, Federico; Oliva, Elena; Urban, Maria L; Palmisano, Alessandra; Santarsia, Francesca; Andrulli, Simeone; Pavone, Laura; Pesci, Alberto; Grasselli, Chiara; Santi, Rosaria; Tumiati, Bruno; Manenti, Lucio; Buzio, Carlo; Vaglio, Augusto

2017-01-01

The treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is based on remission-induction and remission-maintenance. Methotrexate is a widely used immunosuppressant but only a few studies explored its role for maintenance in AAV. This trial investigated the efficacy and safety of methotrexate as maintenance therapy for AAV. In this single-centre, open-label, randomised trial we compared methotrexate and cyclophosphamide for maintenance in AAV. We enrolled patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), the latter with poor-prognosis factors and/or peripheral neuropathy. Remission was induced with cyclophosphamide. At remission, the patients were randomised to receive methotrexate or to continue with cyclophosphamide for 12 months; after treatment, they were followed for another 12 months. The primary end-point was relapse; secondary end-points included renal outcomes and treatment-related toxicity. Of the 94 enrolled patients, 23 were excluded during remission-induction or did not achieve remission; the remaining 71 were randomised to cyclophosphamide (n = 33) or methotrexate (n = 38). Relapse frequencies at months 12 and 24 after randomisation were not different between the two groups (p = 1.00 and 1.00). Relapse-free survival was also comparable (log-rank test p = 0.99). No differences in relapses were detected between the two treatments when GPA+MPA and EGPA were analysed separately. There were no differences in eGFR at months 12 and 24; proteinuria declined significantly (from diagnosis to month 24) only in the cyclophosphamide group (p = 0.0007). No significant differences in adverse event frequencies were observed. MTX may be effective and safe for remission-maintenance in AAV. clinicaltrials.gov NCT00751517.

Minnesota logging utilization factors, 1975-1976--development, use, implications.

Treesearch

James E. Blyth; W. Brad Smith

1979-01-01

Discusses Minnesota saw log and pulpwood logging utilization factors developed during 1975-1976 and their implications. Compares factors for several species groups and shows their use in estimating growing stock cut for pulpwood and saw logs.

Dynamics of Tree Species Diversity in Unlogged and Selectively Logged Malaysian Forests.

PubMed

Shima, Ken; Yamada, Toshihiro; Okuda, Toshinori; Fletcher, Christine; Kassim, Abdul Rahman

2018-01-18

Selective logging that is commonly conducted in tropical forests may change tree species diversity. In rarely disturbed tropical forests, locally rare species exhibit higher survival rates. If this non-random process occurs in a logged forest, the forest will rapidly recover its tree species diversity. Here we determined whether a forest in the Pasoh Forest Reserve, Malaysia, which was selectively logged 40 years ago, recovered its original species diversity (species richness and composition). To explore this, we compared the dynamics of secies diversity between unlogged forest plot (18.6 ha) and logged forest plot (5.4 ha). We found that 40 years are not sufficient to recover species diversity after logging. Unlike unlogged forests, tree deaths and recruitments did not contribute to increased diversity in the selectively logged forests. Our results predict that selectively logged forests require a longer time at least than our observing period (40 years) to regain their diversity.

Lumber Grade Yields for Graded Aspen Logs and Trees

Treesearch

Leland F. Hanks; Robert L. Brisbin

1978-01-01

Green lumber grade yields for aspen were determined for use with the U.S. Forest Service hardwood log and tree grades. The yields for logs are expressed in percent of total lumber tally volume, and those for trees are expressed in board feet. Overruns for the International 1/4-inch and Scribner log rules along with lumber recovery factors are shown by log grade.

Combined Log Inventory and Process Simulation Models for the Planning and Control of Sawmill Operations

Treesearch

Guillermo A. Mendoza; Roger J. Meimban; Philip A. Araman; William G. Luppold

1991-01-01

A log inventory model and a real-time hardwood process simulation model were developed and combined into an integrated production planning and control system for hardwood sawmills. The log inventory model was designed to monitor and periodically update the status of the logs in the log yard. The process simulation model was designed to estimate various sawmill...

36 CFR 223.195 - Procedures for identifying and marking unprocessed timber.

Code of Federal Regulations, 2013 CFR

2013-07-01

... pattern may not be used to mark logs from any other source for a period of 24 months after all logs have..., they shall be replaced. If the log is cut into two or more segments, each segment shall be identified... preserve identification of log pieces shall not apply to logs cut into two or more segments as a part of...

Rapid increase in log populations in drought-stressed mixed-conifer and ponderosa pine forests in northern Arizona

Treesearch

Joseph L. Ganey; Scott C. Vojta

2012-01-01

Down logs provide important ecosystem services in forests and affect surface fuel loads and fire behavior. Amounts and kinds of logs are influenced by factors such as forest type, disturbance regime, forest man-agement, and climate. To quantify potential short-term changes in log populations during a recent global- climate-change type drought, we sampled logs in mixed-...

Solar treatments for reducing survival of mountain pine beetle in infested ponderosa and lodgepole pine logs

Treesearch

Jose F. Negron; Wayne A. Shepperd; Steve A. Mata; John B. Popp; Lance A. Asherin; Anna W. Schoettle; John M. Schmid; David A. Leatherman

2001-01-01

Three experiments were conducted to evaluate the use of solar radiation for reducing survival of mountain pine beetle populations in infested logs. Ponderosa pine logs were used in experiments 1 and 2 and lodgepole pine logs were used in experiment 3. Experiment 1 comprised three treatments: (1) one-layer solar treatment without plastic sheeting and logs rotated one-...

The new idea of transporting tailings-logs in tailings slurry pipeline and the innovation of technology of mining waste-fill method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin Yu; Wang Fuji; Tao Yan

2000-07-01

This paper introduced a new idea of transporting mine tailings-logs in mine tailings-slurry pipeline and a new technology of mine cemented filing of tailings-logs with tailings-slurry. The hydraulic principles, the compaction of tailings-logs and the mechanic function of fillbody of tailings-logs cemented by tailings-slurry have been discussed.

Rill erosion in burned and salvage logged western montane forests: Effects of logging equipment type, traffic level, and slash treatment

Treesearch

J. W. Wagenbrenner; P. R. Robichaud; R. E. Brown

2016-01-01

Following wildfires, forest managers often consider salvage logging burned trees to recover monetary value of timber, reduce fuel loads, or to meet other objectives. Relatively little is known about the cumulative hydrologic effects of wildfire and subsequent timber harvest using logging equipment. We used controlled rill experiments in logged and unlogged (control)...

An Analysis of the Differences among Log Scaling Methods and Actual Log Volume

Treesearch

R. Edward Thomas; Neal D. Bennett

2017-01-01

Log rules estimate the volume of green lumber that can be expected to result from the sawing of a log. As such, this ability to reliably predict lumber recovery forms the foundation of log sales and purchase. The more efficient a sawmill, the less the scaling methods reflect the actual volume recovery and the greater the overrun factor. Using high-resolution scanned...

Tradeoffs and interdependence in the Alaska cant and log markets.

Treesearch

Donald Flora; Una Woller; Michael Neergaard

1990-01-01

During the 1980s, log exports from Alaska have risen while cant (lumber) exports have declined. Eight explanations for the difference between cant and log market behavior are explored. It seems that declining demand for wood products in Japan and a surge of private-sector log harvests in Alaska are enough to account for the apparent substitution of logs for cants. It...

Lumber value differences from reduced CT spatial resolution and simulated log sawing

Treesearch

Suraphan Thawornwong; Luis G. Occena; Daniel L. Schmoldt

2003-01-01

In the past few years, computed tomography (CT) scanning technology has been applied to the detection of internal defects in hardwood logs for the purpose of obtaining a priori information that can be used to arrive at better log sawing decisions. Because sawyers currently cannot even see the inside of a log until the log faces are revealed by sawing, there is little...

Upland log volumes and conifer establishment patterns in two northern, upland old-growth redwood forests, a brief synopsis

Treesearch

Daniel J. Porter; John O. Sawyer

2007-01-01

We characterized the volume, weight and top surface area of naturally fallen logs in an old-growth redwood forest, and quantified conifer recruit densities on these logs and on the surrounding forest floor. We report significantly greater conifer recruit densities on log substrates as compared to the forest floor. Log substrate availability was calculated on a per...

Lumber or chips? A comparison of small-log utilization alternatives

Treesearch

Barney Dowdle; Robert Bain

1961-01-01

A sawmill in the Northeast commonly receives a number of small low-quality logs. They may be among logs purchased from independent loggers, or timber-sale specifications may require that the sawmill take them. Some mill operators confronted with logs of this kind consider handling them as part of the cost of obtaining their log supply. Others may feel that, since the...

Salvage logging in the montane ash eucalypt forests of the Central Highlands of Victoria and its potential impacts on biodiversity.

PubMed

Lindenmayer, D B; Ought, K

2006-08-01

The two major forms of disturbance in the montane ash eucalypt forests of the Central Highlands of Victoria (southeastern Australia) are clearfell logging and unplanned wildfires. Since the 1930s wildfire has been followed by intensive and extensive salvage-logging operations, which may proceed for many years after a wildfire has occurred. Although applied widely, the potential effects of salvage logging on native flora and fauna have been poorly studied. Our data indicate that the abundance of large trees with hollows is significantly reduced in forests subject to salvage harvesting. This has implications for thepersistence of an array of such cavity-using vertebrates as the endangered arboreal marsupial, Leadbeater's possum (Gymnobelidues leadbeateri). Salvage logging also reduces the prevalence of multiaged montane ash forests--places that typically support the highest diversity of arboreal marsupials and forest birds. Limited research has been conducted on the effects of salvage logging on plants; thus, we constructed hypotheses about potential impacts for further testing based on known responses to clearfell logging and key life history attributes. We predict many species, such as vegetatively resprouting tree ferns, will decline, as they do after clearfelling. We also suggest that seed regenerators, which typically regenerate well after fire or conventional clearfelling, will decline after salvage logging because the stimulation for germination (fire) takes place prior to mechanical disturbance (logging). Understoryplant communities in salvage-logged areas will be dominated by a smaller suite of species, and those that are wind dispersed, have viable soil-stored seed remaining after salvage logging, or have deep rhizomes are likely to be advantaged. We recommend the following improvements to salvage-logging policies that may better incorporate conservation needs in Victorian montane ash forests: (1) exemption of salvage logging from some areas (e.g., old-growth stands and places subject to only partial stand damage); (2) increased retention of biological legacies on burned areas through variations in the intensity of salvage logging; and (3) reduction in the levels of physical disturbance on salvage-logged areas, especially through limited seedbed preparation and mechanical disturbance.

Color images of Kansas subsurface geology from well logs

USGS Publications Warehouse

Collins, D.R.; Doveton, J.H.

1986-01-01

Modern wireline log combinations give highly diagnostic information that goes beyond the basic shale content, pore volume, and fluid saturation of older logs. Pattern recognition of geology from logs is made conventionally through either the examination of log overlays or log crossplots. Both methods can be combined through the use of color as a medium of information by setting the three color primaries of blue, green, and red light as axes of three dimensional color space. Multiple log readings of zones are rendered as composite color mixtures which, when plotted sequentially with depth, show lithological successions in a striking manner. The method is extremely simple to program and display on a color monitor. Illustrative examples are described from the Kansas subsurface. ?? 1986.

A Guide to Hardwood Log Grading

Treesearch

Everette D. Rast; David L. Sonderman; Glenn L. Gammon

1973-01-01

A guide to hardwood log grading (revised) was developed as a teaching aid and field reference in grading hardwood logs. Outlines basic principles and gives detailed practical applications, with illustrations, in grading hardwood logs. Includes standards for various use classes.

Bird species and traits associated with logged and unlogged forest in Borneo.

PubMed

Cleary, Daniel F R; Boyle, Timothy J B; Setyawati, Titiek; Anggraeni, Celina D; Van Loon, E Emiel; Menken, Steph B J

2007-06-01

The ecological consequences of logging have been and remain a focus of considerable debate. In this study, we assessed bird species composition within a logging concession in Central Kalimantan, Indonesian Borneo. Within the study area (approximately 196 km2) a total of 9747 individuals of 177 bird species were recorded. Our goal was to identify associations between species traits and environmental variables. This can help us to understand the causes of disturbance and predict whether species with given traits will persist under changing environmental conditions. Logging, slope position, and a number of habitat structure variables including canopy cover and liana abundance were significantly related to variation in bird composition. In addition to environmental variables, spatial variables also explained a significant amount of variation. However, environmental variables, particularly in relation to logging, were of greater importance in structuring variation in composition. Environmental change following logging appeared to have a pronounced effect on the feeding guild and size class structure but there was little evidence of an effect on restricted range or threatened species although certain threatened species were adversely affected. For example, species such as the terrestrial insectivore Argusianus argus and the hornbill Buceros rhinoceros, both of which are threatened, were rare or absent in recently logged forest. In contrast, undergrowth insectivores such as Orthotomus atrogularis and Trichastoma rostratum were abundant in recently logged forest and rare in unlogged forest. Logging appeared to have the strongest negative effect on hornbills, terrestrial insectivores, and canopy bark-gleaning insectivores while moderately affecting canopy foliage-gleaning insectivores and frugivores, raptors, and large species in general. In contrast, undergrowth insectivores responded positively to logging while most understory guilds showed little pronounced effect. Despite the high species richness of logged forest, logging may still have a negative impact on extant diversity by adversely affecting key ecological guilds. The sensitivity of hornbills in particular to logging disturbance may be expected to alter rainforest dynamics by seriously reducing the effective seed dispersal of associated tree species. However, logged forest represents an increasingly important habitat for most bird species and needs to be protected from further degradation. Biodiversity management within logging concessions should focus on maintaining large areas of unlogged forest and mitigating the adverse effects of logging on sensitive groups of species.

Logging while fishing: An alternate method to cut and thread fishing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tollefsen, E.; Crary, S.; Flores, B.

1996-12-31

New technology has been introduced to allow completion of the wireline logging program after the tool string has become lodged in the wellbore. Charges associated with extracting a stuck tool are substantial. These charges result from the nonproductive time during the fishing trip, an associated wiper trip, and re-logging the well. The ability to continue the logging program while retrieving the logging string from the wellbore is needed. Logging While Fishing (LWF) is a hybrid of existing technologies combined with a new sub capable of severing a cable remotely. This new method is comprised of cut and thread fishing, drillpipemore » conveyed logging, and bridled tool techniques. Utilizing these techniques it is possible to complete wireline logging operations while removing a stuck tool from the wellbore. Completing logging operations using this hybrid method will save operating companies time and money. Other benefits, depending on the situation, include reduced fishing time and an increased level of safety. This application has been demonstrated on jobs in the Gulf of Mexico, North Sea, Venezuela, and Southeast Asia.« less

Effects of Milk vs Dark Chocolate Consumption on Visual Acuity and Contrast Sensitivity Within 2 Hours: A Randomized Clinical Trial.

PubMed

Rabin, Jeff C; Karunathilake, Nirmani; Patrizi, Korey

2018-04-26

Consumption of dark chocolate can improve blood flow, mood, and cognition in the short term, but little is known about the possible effects of dark chocolate on visual performance. To compare the short-term effects of consumption of dark chocolate with those of milk chocolate on visual acuity and large- and small-letter contrast sensitivity. A randomized, single-masked crossover design was used to assess short-term visual performance after consumption of a dark or a milk chocolate bar. Thirty participants without pathologic eye disease each consumed dark and milk chocolate in separate sessions, and within-participant paired comparisons were used to assess outcomes. Testing was conducted at the Rosenberg School of Optometry from June 25 to August 15, 2017. Visual acuity (in logMAR units) and large- and small-letter contrast sensitivity (in the log of the inverse of the minimum detectable contrast [logCS units]) were measured 1.75 hours after consumption of dark and milk chocolate bars. Among the 30 participants (9 men and 21 women; mean [SD] age, 26 [5] years), small-letter contrast sensitivity was significantly higher after consumption of dark chocolate (mean [SE], 1.45 [0.04] logCS) vs milk chocolate (mean [SE], 1.30 [0.05] logCS; mean improvement, 0.15 logCS [95% CI, 0.08-0.22 logCS]; P < .001). Large-letter contrast sensitivity was slightly higher after consumption of dark chocolate (mean [SE], 2.05 [0.02] logCS) vs milk chocolate (mean [SE], 2.00 [0.02] logCS; mean improvement, 0.05 logCS [95% CI, 0.00-0.10 logCS]; P = .07). Visual acuity improved slightly after consumption of dark chocolate (mean [SE], -0.22 [0.01] logMAR; visual acuity, approximately 20/12) and milk chocolate (mean [SE], -0.18 [0.01] logMAR; visual acuity, approximately 20/15; mean improvement, 0.04 logMAR [95% CI, 0.02-0.06 logMAR]; P = .05). Composite scores combining results from all tests showed significant improvement after consumption of dark compared with milk chocolate (mean improvement, 0.20 log U [95% CI, 0.10-0.30 log U]; P < .001). Contrast sensitivity and visual acuity were significantly higher 2 hours after consumption of a dark chocolate bar compared with a milk chocolate bar, but the duration of these effects and their influence in real-world performance await further testing. clinicaltrials.gov Identifier: NCT03326934.

Growth and Survival of Acid-Resistant and Non-Acid-Resistant Shiga-Toxin-Producing Escherichia coli Strains during the Manufacture and Ripening of Camembert Cheese.

PubMed

Montet, M P; Jamet, E; Ganet, S; Dizin, M; Miszczycha, S; Dunière, L; Thevenot, D; Vernozy-Rozand, C

2009-01-01

Growth and survival of acid-resistant (AR) and non-acid-resistant (NAR) Shiga-toxin-producing Escherichia coli (STEC) strains were investigated during the manufacture and ripening of microfiltered milk Camembert cheeses. The induction of acid resistance of the STEC strains in cheeses was also studied. Six different mixtures of AR and/or NAR STEC strains were inoculated separately into microfiltered milk at a level of 10(3) CFU mL(-1). The STEC counts (AR and NAR) initially increased by 1 to 2 log(10) CFU g(-1) during cheese-making. Thereafter, the populations stabilized during salting/drying and then decreased during the early stages of ripening. Exposing the STEC strains in artificially inoculated cheeses to simulated gastric fluid (SGF - pH: 2.0) reduced the number of NAR strains to undetectable levels within 40 minutes, versus 120 minutes for the AR STEC strains. AR and NAR STEC were able to survive during the manufacture and ripening of Camembert cheese prepared from microfiltered milk with no evidence of induced acid tolerance in NAR STEC strains.

Relation of morphology of electrodeposited zinc to ion concentration profile

NASA Technical Reports Server (NTRS)

May, C. E.; Kautz, H. E.; Sabo, B. B.

1977-01-01

The morphology of electrodeposited zinc was studied with special attention to the ion concentration profile. The initial concentrations were 9M hydroxide ion and 1.21M zincate. Current densities were 6.4 to 64 mA/sq cm. Experiments were run with a horizontal cathode which was observed in situ using a microscope. The morphology of the zinc deposit was found to be a function of time as well as current density; roughly, the log of the transition time from mossy to large crystalline type deposit is inversely proportional to current density. Probe electrodes indicated that the electrolyte in the cathode chamber was mixed by self inducted convection. However, relatively large concentration gradients of the involved species existed across the boundary layer of the cathode. Analysis of the data suggests that the morphology converts from mossy to large crystalline when the hydroxide activity on the cathode surface exceeds about 12 M. Other experiments show that the pulse discharge technique had no effect on the morphology in the system where the bulk concentration of the electrolyte was kept homogeneous via self induced convection.

Four decades of the kidney transplantation program at the Institute Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in Mexico City.

PubMed

Morales-Buenrostro, Luis E; Marino-Vázquez, Lluvia A; Alberú, Josefina

2009-01-01

This is a retrospective study that includes four decades of kidney transplant program at our Institute, with a total of 923 kidney transplants in 872 recipients. In this report, the effect of variables in recipient, donor, and transplant on long-term graft survival was analyzed using the Kaplan Meier method with log-rank test for survival comparisons. Global graft survival at our center-analyzed by censoring for death-with-functioning-graft-for 1, 5 and 10 years was 93%, 83% and 74%, respectively, with median survival of 24.5 years. When analyzed for all-cause graft loss, 1, 5 and 10 year survival was 90%, 76% and 61%, with 12.8-year median survival. Variables associated with lower graft survival censored for death-with-functioning-graft were transplantation in an earlier decade, less histocompatibility, younger kidney transplant recipients, no induction therapy, and double drug initial immunosuppression. After Cox's regression multivariate analysis, the risk factors that remained associated with worse survival were younger recipient, earlier transplant decade, and deceased donor.

Extension of structure-reactivity correlations for the hydrogen abstraction reaction to methyl radical and comparison to chlorine atom, bromine atom, and hydroxyl radical

DOE PAGES

Poutsma, Marvin L.

2016-06-07

In this study, we presented structure-reactivity correlations for the gas-phase rate constants for hydrogen abstraction from sp3-hybridized carbon by three electrophilic radicals (X • + HCR 3 → XH + •CR 3; X = Cl •, HO •, and Br); the reaction enthalpy effect was represented by the independent variable Δ rH and the polar effect by the independent variables F and R, the Hammett-Taft constants for field/inductive and resonance effects. Here we present a parallel treatment for the less electronegative CH 3 •. In spite of a limited and scattered data base, the resulting least-squares fit [log k 437(CHmore » 3 •) = 0.0251(Δ rH) + 0.96(ΣF) 0.56(ΣR) – 19.15] was modestly successful and useful for initial predictions. As expected, the polar effect appears to be minor and its directionality, i.e., the philicity of CH 3, may depend on the nature of the substituents.« less

Water analysis via portable X-ray fluorescence spectrometry

NASA Astrophysics Data System (ADS)

Pearson, Delaina; Chakraborty, Somsubhra; Duda, Bogdan; Li, Bin; Weindorf, David C.; Deb, Shovik; Brevik, Eric; Ray, D. P.

2017-01-01

Rapid, in-situ elemental water analysis would be an invaluable tool in studying polluted and/or salt-impacted waters. Analysis of water salinity has commonly used electrical conductance (EC); however, the identity of the elements responsible for the salinity are not revealed using EC. Several studies have established the viability of using portable X-ray fluorescence (PXRF) spectrometry for elemental data analysis of soil, sediment, and other matrices. However, the accuracy of PXRF is known to be affected while scanning moisture-laden soil samples. This study used PXRF elemental data in water samples to predict water EC. A total of 256 water samples, from 10 different countries were collected and analyzed via PXRF, inductively coupled plasma atomic emission spectroscopy (ICP-AES), and a digital salinity bridge. The PXRF detected some elements more effectively than others, but overall results indicated that PXRF can successfully predict water EC via quantifying Cl in water samples (validation R2 and RMSE of 0.77 and 0.95 log μS cm-1, respectively). The findings of this study elucidated the potential of PXRF for future analysis of pollutant and/or metal contaminated waters.

Thermodynamic modeling of solid solutions between monosulfate and monochromate 3CaO Bullet Al{sub 2}O{sub 3} Bullet Ca[(CrO{sub 4}){sub x}(SO{sub 4}){sub 1-x}] Bullet nH{sub 2}O

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leisinger, Sabine M., E-mail: sabine.leisinger@eawag.ch; Institute of Biogeochemistry and Pollutant Dynamics, ETH, CH-8092 Zurich; Lothenbach, Barbara

2012-01-15

In hydrated cement paste AFm-phases are regarded to play an important role in the binding of the toxic contaminant chromate through isomorphic substitution with sulfate. Solid solutions formation can lower the solubility of the solids, thus reducing chromate leaching concentrations. Solid solutions between monosulfate and monochromate were synthesized and characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (EDX) and inductive coupled plasma optical emission spectroscopy (ICP-OES). Based on the measured ion concentrations in solution total solubility products of the solid solution series were determined. For pure monochromate a logK = - 28.4more » {+-} 0.7 was determined. Results from solid and solution analysis showed that limited solid solutions exist. Based on XRD diffractograms a solid solution with a miscibility gap 0.15 < Crx < 0.85 with a dimensionless Guggenheim parameter of 2.43 was proposed.« less

Borehole geophysical data for the East Poplar oil field area, Fort Peck Indian Reservation, northeastern Montana, 1993, 2004, and 2005

USGS Publications Warehouse

Smith, Bruce D.; Thamke, Joanna N.; Tyrrell, Christa

2014-01-01

Areas of high electrical conductivity in shallow aquifers in the East Poplar oil field area were delineated by the U.S. Geological Survey (USGS), in cooperation with the Fort Peck Assiniboine and Sioux Tribes, in order to interpret areas of saline-water contamination. Ground, airborne, and borehole geophysical data were collected in the East Poplar oil field area from 1992 through 2005 as part of this delineation. This report presents borehole geophysical data for thirty-two wells that were collected during, 1993, 2004, and 2005 in the East Poplar oil field study area. Natural-gamma and induction instruments were used to provide information about the lithology and conductivity of the soil, rock, and water matrix adjacent to and within the wells. The well logs were also collected to provide subsurface controls for interpretation of a helicopter electromagnetic survey flown over most of the East Poplar oil field in 2004. The objective of the USGS studies was to improve understanding of aquifer hydrogeology particularly in regard to variations in water quality.

Synthesis, Characterization, and Antimicrobial Efficacy of Photomicrobicidal Cellulose Paper.

PubMed

Carpenter, Bradley L; Scholle, Frank; Sadeghifar, Hasan; Francis, Aaron J; Boltersdorf, Jonathan; Weare, Walter W; Argyropoulos, Dimitris S; Maggard, Paul A; Ghiladi, Reza A

2015-08-10

Toward our goal of scalable, antimicrobial materials based on photodynamic inactivation, paper sheets comprised of photosensitizer-conjugated cellulose fibers were prepared using porphyrin and BODIPY photosensitizers, and characterized by spectroscopic (infrared, UV-vis diffuse reflectance, inductively coupled plasma optical emission) and physical (gel permeation chromatography, elemental, and thermal gravimetric analyses) methods. Antibacterial efficacy was evaluated against Staphylococcus aureus (ATCC-2913), vancomycin-resistant Enterococcus faecium (ATCC-2320), Acinetobacter baumannii (ATCC-19606), Pseudomonas aeruginosa (ATCC-9027), and Klebsiella pneumoniae (ATCC-2146). Our best results were achieved with a cationic porphyrin-paper conjugate, Por((+))-paper, with inactivation upon illumination (30 min, 65 ± 5 mW/cm(2), 400-700 nm) of all bacterial strains studied by 99.99+% (4 log units), regardless of taxonomic classification. Por((+))-paper also inactivated dengue-1 virus (>99.995%), influenza A (∼ 99.5%), and human adenovirus-5 (∼ 99%). These results demonstrate the potential of cellulose materials to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action.

Extension of structure-reactivity correlations for the hydrogen abstraction reaction to methyl radical and comparison to chlorine atom, bromine atom, and hydroxyl radical

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poutsma, Marvin L.

In this study, we presented structure-reactivity correlations for the gas-phase rate constants for hydrogen abstraction from sp3-hybridized carbon by three electrophilic radicals (X • + HCR 3 → XH + •CR 3; X = Cl •, HO •, and Br); the reaction enthalpy effect was represented by the independent variable Δ rH and the polar effect by the independent variables F and R, the Hammett-Taft constants for field/inductive and resonance effects. Here we present a parallel treatment for the less electronegative CH 3 •. In spite of a limited and scattered data base, the resulting least-squares fit [log k 437(CHmore » 3 •) = 0.0251(Δ rH) + 0.96(ΣF) 0.56(ΣR) – 19.15] was modestly successful and useful for initial predictions. As expected, the polar effect appears to be minor and its directionality, i.e., the philicity of CH 3, may depend on the nature of the substituents.« less

55. VIEW OF STEAMOPERATED LOG HOIST TO PUT IN COMING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. VIEW OF STEAM-OPERATED LOG HOIST TO PUT IN COMING LOGS INTO RALPH HULL LUMBER CO. LOG POND. PHOTOGRAPHER: UNKNOWN. DATE: 1942. COURTESY OF RALPH HULL. - Hull-Oakes Lumber Company, 23837 Dawson Road, Monroe, Benton County, OR

A collection of log rules

Treesearch

Frank Freese

1973-01-01

A log rule may be defined as a table or formula showing the estimated net yield for logs of a given diameter and length. Ordinarily the yield is expressed in terms of board feet of finished lumber, though a few rules give the cubic volume of the log or some fraction of it. Built into each log rule are allowances for losses due to such things as slabs, saw kerf, edgings...

Log and tree sawing times for hardwood mills

Treesearch

Everette D. Rast

1974-01-01

Data on 6,850 logs and 1,181 trees were analyzed to predict sawing times. For both logs and trees, regression equations were derived that express (in minutes) sawing time per log or tree and per Mbf. For trees, merchantable height is expressed in number of logs as well as in feet. One of the major uses for the tables of average sawing times is as a bench mark against...

Persistence of historical logging impacts on channel form in mainstem North Fork Caspar Creek

Treesearch

Michael B. Napolitano

1998-01-01

The old-growth redwood forest of North Fork Caspar Creek was clear-cut logged between 1860 and 1904. Transportation of logs involved construction of a splash dam in the headwaters of North Fork Caspar Creek. Water stored behind the dam was released during large storms to enable log drives. Before log drives could be conducted, the stream channel had to be prepared by...

A novel method for quantitative geosteering using azimuthal gamma-ray logging.

PubMed

Yuan, Chao; Zhou, Cancan; Zhang, Feng; Hu, Song; Li, Chaoliu

2015-02-01

A novel method for quantitative geosteering by using azimuthal gamma-ray logging is proposed. Real-time up and bottom gamma-ray logs when a logging tool travels through a boundary surface with different relative dip angles are simulated with the Monte Carlo method. Study results show that response points of up and bottom gamma-ray logs when the logging tool moves towards a highly radioactive formation can be used to predict the relative dip angle, and then the distance from the drilling bit to the boundary surface is calculated. Copyright © 2014 Elsevier Ltd. All rights reserved.

Removal of Encephalitozoon intestinalis, calicivirus, and coliphages by conventional drinking water treatment.

PubMed

Gerba, Charles P; Riley, Kelley R; Nwachuku, Nena; Ryu, Hodon; Abbaszadegan, Morteza

2003-07-01

The removal of the Microsporidia, Encephalitozoon intestinalis, feline calicivirus and coliphages MS-2, PRD-1, and Fr were evaluated during conventional drinking water treatment in a pilot plant. The treatment consisted of coagulation, sedimentation, and mixed media filtration. Fr coliphage was removed the most (3.21 log), followed by feline calicivirus (3.05 log), E. coli (2.67 log), E. intestinalis (2.47 log), MS-2 (2.51 log). and PRD-1 (1.85 log). With the exception of PRD-1 the greatest removal of the viruses occurred during the flocculation step of the water treatment process.

Evaluation of geophysical logs, Phase II, November 1998 to May 1999, at Crossley Farms Superfund Site, Berks County, Pennsylvania

USGS Publications Warehouse

Conger, Randall W.

2000-01-01

Between November 1998 and May 1999, geophysical logging was conducted in 29 boreholes at the Crossley Farms Superfund Site, Hereford Township, Berks County, Pa., to determine the fluidproducing zones, fluid-receiving zones, zones of vertical borehole flow, and casing depth. The wells range in depth from 96 to 500 feet below land surface. Gamma logs only were collected in three bedrock wells. The geophysical logging determined the placement of well screens and packers, which allow monitoring and sampling of water-bearing zones in the fractured bedrock so that the horizontal and vertical distribution of contaminated ground water migrating from known sources could be determined. Geophysical logging included collection of caliper, video, fluid-temperature, fluid-resistivity, single-point-resistance, natural-gamma, fluid-flow, and acoustic-televiewer logs. Caliper and video logs were used to locate fractures, joints, and weathered zones. Inflections on fluidtemperature and fluid-resistivity logs indicated possible water-bearing fractures, and flowmeter measurements verified these locations. Single-point-resistance and natural-gamma logs provided information on stratigraphy. After interpretation of geophysical, video logs, and drillers notes, 24 of the wells were reconstructed such that water levels can be monitored and water samples collected from discrete water-bearing fractures in each well.

Emergency medicine clerkship encounter and procedure logging using handheld computers.

PubMed

Penciner, Rick; Siddiqui, Sanam; Lee, Shirley

2007-08-01

Tracking medical student clinical encounters is now an accreditation requirement of medical schools. The use of handheld computers for electronic logging is emerging as a strategy to achieve this. To evaluate the technical feasibility and student satisfaction of a novel electronic logging and feedback program using handheld computers in the emergency department. This was a survey study of fourth-year medical student satisfaction with the use of their handheld computers for electronic logging of patient encounters and procedures. The authors also included an analysis of this technology. Forty-six students participated in this pilot project, logging a total of 2,930 encounters. Students used the logs an average of 7.6 shifts per rotation, logging an average of 8.3 patients per shift. Twenty-nine students (63%) responded to the survey. Students generally found it easy to complete each encounter (69%) and easy to synchronize their handheld computer with the central server (83%). However, half the students (49%) never viewed the feedback Web site and most (79%) never reviewed their logs with their preceptors. Overall, only 17% found the logging program beneficial as a learning tool. Electronic logging by medical students during their emergency medicine clerkship has many potential benefits as a method to document clinical encounters and procedures performed. However, this study demonstrated poor compliance and dissatisfaction with the process. In order for electronic logging using handheld computers to be a beneficial educational tool for both learners and educators, obstacles to effective implementation need to be addressed.

49 CFR 393.116 - What are the rules for securing logs?

Code of Federal Regulations, 2014 CFR

2014-10-01

... §§ 393.100 through 393.114. (3) Firewood, stumps, log debris and other such short logs must be...: (i) There is no space between the two stacks of logs; (ii) The outside of each stack is raised at...

49 CFR 393.116 - What are the rules for securing logs?

Code of Federal Regulations, 2011 CFR

2011-10-01

... §§ 393.100 through 393.114. (3) Firewood, stumps, log debris and other such short logs must be...: (i) There is no space between the two stacks of logs; (ii) The outside of each stack is raised at...

49 CFR 393.116 - What are the rules for securing logs?

Code of Federal Regulations, 2010 CFR

2010-10-01

... §§ 393.100 through 393.114. (3) Firewood, stumps, log debris and other such short logs must be...: (i) There is no space between the two stacks of logs; (ii) The outside of each stack is raised at...

A Loblolly Pine Management Guide: Managing Site Damage from Logging

Treesearch

W.H. McKee; G.E. Hatchell; A.E. Tiarks

1985-01-01

Serious damage to forest sites during logging can be avoided through careful planning of logging, preparation of the site for logging, and close supervision of the work.Losses in productivity caused by compaction can be largely restored by cultivation and fertilization.

49 CFR 393.116 - What are the rules for securing logs?

Code of Federal Regulations, 2013 CFR

2013-10-01

... §§ 393.100 through 393.114. (3) Firewood, stumps, log debris and other such short logs must be...: (i) There is no space between the two stacks of logs; (ii) The outside of each stack is raised at...

49 CFR 393.116 - What are the rules for securing logs?

Code of Federal Regulations, 2012 CFR

2012-10-01

... §§ 393.100 through 393.114. (3) Firewood, stumps, log debris and other such short logs must be...: (i) There is no space between the two stacks of logs; (ii) The outside of each stack is raised at...

Line-driven disc wind model for ultrafast outflows in active galactic nuclei - scaling with luminosity

NASA Astrophysics Data System (ADS)

Nomura, M.; Ohsuga, K.

2017-03-01

In order to reveal the origin of the ultrafast outflows (UFOs) that are frequently observed in active galactic nuclei (AGNs), we perform two-dimensional radiation hydrodynamics simulations of the line-driven disc winds, which are accelerated by the radiation force due to the spectral lines. The line-driven winds are successfully launched for the range of MBH = 106-9 M⊙ and ε = 0.1-0.5, and the resulting mass outflow rate (dot{M_w}), momentum flux (dot{p_w}), and kinetic luminosity (dot{E_w}) are in the region containing 90 per cent of the posterior probability distribution in the dot{M}_w-Lbol plane, dot{p}_w-Lbol plane, and dot{E}_w-Lbol plane shown in Gofford et al., where MBH is the black hole mass, ε is the Eddington ratio, and Lbol is the bolometric luminosity. The best-fitting relations in Gofford et al., d log dot{M_w}/d log {L_bol}˜ 0.9, d log dot{p_w}/d log {L_bol}˜ 1.2, and d log dot{E_w}/d log {L_bol}˜ 1.5, are roughly consistent with our results, d log dot{M_w}/d log {L_bol}˜ 9/8, d log dot{p_w}/d log {L_bol}˜ 10/8, and d log dot{E_w}/d log {L_bol}˜ 11/8. In addition, our model predicts that no UFO features are detected for the AGNs with ε ≲ 0.01, since the winds do not appear. Also, only AGNs with MBH ≲ 108 M⊙ exhibit the UFOs when ε ∼ 0.025. These predictions nicely agree with the X-ray observations. These results support that the line-driven disc wind is the origin of the UFOs.

Borehole geophysics applied to ground-water investigations

USGS Publications Warehouse

Keys, W.S.

1990-01-01

The purpose of this manual is to provide hydrologists, geologists, and others who have the necessary background in hydrogeology with the basic information needed to apply the most useful borehole-geophysical-logging techniques to the solution of problems in ground-water hydrology. Geophysical logs can provide information on the construction of wells and on the character of the rocks and fluids penetrated by those wells, as well as on changes in the character of these factors over time. The response of well logs is caused by petrophysical factors, by the quality, temperature, and pressure of interstitial fluids, and by ground-water flow. Qualitative and quantitative analysis of analog records and computer analysis of digitized logs are used to derive geohydrologic information. This information can then be extrapolated vertically within a well and laterally to other wells using logs. The physical principles by which the mechanical and electronic components of a logging system measure properties of rocks, fluids, and wells, as well as the principles of measurement, must be understood if geophysical logs are to be interpreted correctly. Plating a logging operation involves selecting the equipment and the logs most likely to provide the needed information. Information on well construction and geohydrology is needed to guide this selection. Quality control of logs is an important responsibility of both the equipment operator and the log analyst and requires both calibration and well-site standardization of equipment. Logging techniques that are widely used in ground-water hydrology or that have significant potential for application to this field include spontaneous potential, resistance, resistivity, gamma, gamma spectrometry, gamma-gamma, neutron, acoustic velocity, acoustic televiewer, caliper, and fluid temperature, conductivity, and flow. The following topics are discussed for each of these techniques: principles and instrumentation, calibration and standardization, volume of investigation, extraneous effects, and interpretation and applications.

Borehole geophysics applied to ground-water investigations

USGS Publications Warehouse

Keys, W.S.

1988-01-01

The purpose of this manual is to provide hydrologists, geologists, and others who have the necessary training with the basic information needed to apply the most useful borehole-geophysical-logging techniques to the solution of problems in ground-water hydrology. Geophysical logs can provide information on the construction of wells and on the character of the rocks and fluids penetrated by those wells, in addition to changes in the character of these factors with time. The response of well logs is caused by: petrophysical factors; the quality; temperature, and pressure of interstitial fluids; and ground-water flow. Qualitative and quantitative analysis of the analog records and computer analysis of digitized logs are used to derive geohydrologic information. This information can then be extrapolated vertically within a well and laterally to other wells using logs.The physical principles by which the mechanical and electronic components of a logging system measure properties of rocks, fluids and wells, and the principles of measurement need to be understood to correctly interpret geophysical logs. Planning the logging operation involves selecting the equipment and the logs most likely to provide the needed information. Information on well construction and geohydrology are needed to guide this selection. Quality control of logs is an important responsibility of both the equipment operator and log analyst and requires both calibration and well-site standardization of equipment.Logging techniques that are widely used in ground-water hydrology or that have significant potential for application to this field include: spontaneous potential, resistance, resistivity, gamma, gamma spectrometry, gamma-gamma, neutron, acoustic velocity, acoustic televiewer, caliper, and fluid temperature, conductivity, and flow. The following topics are discussed for each of these techniques: principles and instrumentation, calibration and standardization, volume of investigation, extraneous effects, and interpretation and applications.

Use of NMR logging to obtain estimates of hydraulic conductivity in the High Plains aquifer, Nebraska, USA

USGS Publications Warehouse

Dlubac, Katherine; Knight, Rosemary; Song, Yi-Qiao; Bachman, Nate; Grau, Ben; Cannia, Jim; Williams, John

2013-01-01

Hydraulic conductivity (K) is one of the most important parameters of interest in groundwater applications because it quantifies the ease with which water can flow through an aquifer material. Hydraulic conductivity is typically measured by conducting aquifer tests or wellbore flow (WBF) logging. Of interest in our research is the use of proton nuclear magnetic resonance (NMR) logging to obtain information about water-filled porosity and pore space geometry, the combination of which can be used to estimate K. In this study, we acquired a suite of advanced geophysical logs, aquifer tests, WBF logs, and sidewall cores at the field site in Lexington, Nebraska, which is underlain by the High Plains aquifer. We first used two empirical equations developed for petroleum applications to predict K from NMR logging data: the Schlumberger Doll Research equation (KSDR) and the Timur-Coates equation (KT-C), with the standard empirical constants determined for consolidated materials. We upscaled our NMR-derived K estimates to the scale of the WBF-logging K(KWBF-logging) estimates for comparison. All the upscaled KT-C estimates were within an order of magnitude of KWBF-logging and all of the upscaled KSDR estimates were within 2 orders of magnitude of KWBF-logging. We optimized the fit between the upscaled NMR-derived K and KWBF-logging estimates to determine a set of site-specific empirical constants for the unconsolidated materials at our field site. We conclude that reliable estimates of K can be obtained from NMR logging data, thus providing an alternate method for obtaining estimates of K at high levels of vertical resolution.

High-throughput determination of octanol/water partition coefficients using a shake-flask method and novel two-phase solvent system.

PubMed

Morikawa, Go; Suzuka, Chihiro; Shoji, Atsushi; Shibusawa, Yoichi; Yanagida, Akio

2016-01-05

A high-throughput method for determining the octanol/water partition coefficient (P(o/w)) of a large variety of compounds exhibiting a wide range in hydrophobicity was established. The method combines a simple shake-flask method with a novel two-phase solvent system comprising an acetonitrile-phosphate buffer (0.1 M, pH 7.4)-1-octanol (25:25:4, v/v/v; AN system). The AN system partition coefficients (K(AN)) of 51 standard compounds for which log P(o/w) (at pH 7.4; log D) values had been reported were determined by single two-phase partitioning in test tubes, followed by measurement of the solute concentration in both phases using an automatic flow injection-ultraviolet detection system. The log K(AN) values were closely related to reported log D values, and the relationship could be expressed by the following linear regression equation: log D=2.8630 log K(AN) -0.1497(n=51). The relationship reveals that log D values (+8 to -8) for a large variety of highly hydrophobic and/or hydrophilic compounds can be estimated indirectly from the narrow range of log K(AN) values (+3 to -3) determined using the present method. Furthermore, log K(AN) values for highly polar compounds for which no log D values have been reported, such as amino acids, peptides, proteins, nucleosides, and nucleotides, can be estimated using the present method. The wide-ranging log D values (+5.9 to -7.5) of these molecules were estimated for the first time from their log K(AN) values and the above regression equation. Copyright © 2015 Elsevier B.V. All rights reserved.

Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study.

PubMed

Shearman, A M; Ordovas, J M; Cupples, L A; Schaefer, E J; Harmon, M D; Shao, Y; Keen, J D; DeStefano, A L; Joost, O; Wilson, P W; Housman, D E; Myers, R H

2000-05-22

Some studies show that plasma triglyceride (TG) levels are a significant independent risk factor for cardiovascular disease (CVD). TG levels are inversely correlated with high density lipoprotein cholesterol (HDL-C) levels, and their metabolism may be closely interrelated. Therefore, the TG/HDL-C ratio may be a relevant CVD risk factor. Our analysis of families in the Framingham Heart Study gave a genetic heritability estimate for log(TG) of 0.40 and for log(TG/HDL-C) of 0.49, demonstrating an important genetic component for both. A 10 cM genome-wide scan for log(TG) level and log(TG/HDL-C) was carried out for the largest 332 extended families of the Framingham Heart Study (1702 genotyped individuals). The highest multipoint variance component LOD scores obtained for both log(TG) and log(TG/HDL-C) were on chromosome 7 (at 155 cM), where the results for the two phenotypes were 1.8 and 2.5, respectively. The 7q32.3-qter region contains several candidate genes. Four other regions with multipoint LOD scores greater than one were identified on chromosome 3 [LOD score for log(TG/HDL-C) = 1.8 at 140 cM], chromosome 11 [LOD score for log(TG/HDL-C) = 1.1 at 125 cM], chromosome 16 [LOD score for log(TG) = 1.5 at 70 cM, LOD score for log(TG/HDL-C) = 1.1 at 75 cM] and chromosome 20 [LOD score for log(TG/HDL-C) = 1.7 at 35 cM, LOD score for log(TG) = 1.3 at 40 cM]. These results identify loci worthy of further study.

Production and receipts of veneer logs in the Southeastern and Midsouth States, 1988

Treesearch

John B. Tansey; Dennis M. May

1991-01-01

Veneer-log production in the 12 Southern States totaled 4.7 billion board feet in 1988, up 11 percent from 1984. In 1988, 151 mills in the south received 4.7 billion board feet of veneer logs. In 1988 imports of veneer logs into the South exceeded exports by 17 million board feet. Yellow pines make up 90 percent of the South.s harvest of veneer logs. Ninety percent of...

The effect of curve sawing two-sided cants from small diameter hardwood sawlogs on lumber and pallet part yields

Treesearch

Peter Hamner; Marshall S. White; Philip A. Araman

2006-01-01

Curve sawing is a primary log breakdown process that incorporates gang-saw technology to allow two-sided cants from logs with sweep to be cut parallel to the log surface or log axis. Since curve-sawn logs with sweep are cut along the grain, the potential for producing high quality straight-grain lumber and cants increases, and strength, stiffness, and dimensional...

Surface covering of downed logs: drivers of a neglected process in dead wood ecology.

PubMed

Dynesius, Mats; Gibb, Heloise; Hjältén, Joakim

2010-10-07

Many species use coarse woody debris (CWD) and are disadvantaged by the forestry-induced loss of this resource. A neglected process affecting CWD is the covering of the surfaces of downed logs caused by sinking into the ground (increasing soil contact, mostly covering the underside of the log), and dense overgrowth by ground vegetation. Such cover is likely to profoundly influence the quality and accessibility of CWD for wood-inhabiting organisms, but the factors affecting covering are largely unknown. In a five-year experiment we determined predictors of covering rate of fresh logs in boreal forests and clear-cuts. Logs with branches were little covered because they had low longitudinal ground contact. For branchless logs, longitudinal ground contact was most strongly related to estimated peat depth (positive relation). The strongest predictor for total cover of branchless logs was longitudinal ground contact. To evaluate the effect on cover of factors other than longitudinal ground contact, we separately analyzed data from only those log sections that were in contact with the ground. Four factors were prominent predictors of percentage cover of such log sections: estimated peat depth, canopy shade (both increasing cover), potential solar radiation calculated from slope and slope aspect, and diameter of the log (both reducing cover). Peat increased cover directly through its low resistance, which allowed logs to sink and soil contact to increase. High moisture and low temperatures in pole-ward facing slopes and under a canopy favor peat formation through lowered decomposition and enhanced growth of peat-forming mosses, which also proved to rapidly overgrow logs. We found that in some boreal forests, peat and fast-growing mosses can rapidly cover logs lying on the ground. When actively introducing CWD for conservation purposes, we recommend that such rapid covering is avoided, thereby most likely improving the CWD's longevity as habitat for many species.

3. Log bunkhouse (far left), log chicken house (left of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Log bunkhouse (far left), log chicken house (left of center), equipment shed (center), and workshop (far right). View to northwest. - William & Lucina Bowe Ranch, County Road 44, 0.1 mile northeast of Big Hole River Bridge, Melrose, Silver Bow County, MT

Hardwood log grading scale stick improved

Treesearch

M. D. Ostrander; G. H. Englerth

1953-01-01

In February 1952 the Northeastern Forest Experiment Station described ( Research Note 13) a new log-grading scale stick developed by the Station for use as a visual aid in grading hardwood factory logs. It was based on the U. S. Forest Products Laboratory's log-grade specifications.

The electronic spectra and the structures of the individual copper(II) chloride and bromide complexes in acetonitrile according to steady-state absorption spectroscopy and DFT/TD-DFT calculations

NASA Astrophysics Data System (ADS)

Olshin, Pavel K.; Myasnikova, Olesya S.; Kashina, Maria V.; Gorbunov, Artem O.; Bogachev, Nikita A.; Kompanets, Viktor O.; Chekalin, Sergey V.; Pulkin, Sergey A.; Kochemirovsky, Vladimir A.; Skripkin, Mikhail Yu.; Mereshchenko, Andrey S.

2018-03-01

The results of spectrophotometric study and quantum chemical calculations for copper(II) chloro- and bromocomplexes in acetonitrile are reported. Electronic spectra of the individual copper(II) halide complexes were obtained in a wide spectral range 200-2200 nm. Stability constants of the individual copper(II) halide complexes in acetonitrile were calculated: log β1 = 8.5, log β2 = 15.6, log β3 = 22.5, log β4 = 25.7 for [CuCln]2-n and log β1 = 17.0, log β2 = 24.6, log β3 = 28.1, log β4 = 30.4 for [CuBrn]2-n. Structures of the studied complexes were optimized and electronic spectra were simulated using DFT and TD-DFT methodologies, respectively. According to the calculations, the more is the number of halide ligands the less is coordination number of copper ion.

Evaluation of waste mushroom logs as a potential biomass resource for the production of bioethanol.

PubMed

Lee, Jae-Won; Koo, Bon-Wook; Choi, Joon-Weon; Choi, Don-Ha; Choi, In-Gyu

2008-05-01

In order to investigate the possibility of using waste mushroom logs as a biomass resource for alternative energy production, the chemical and physical characteristics of normal wood and waste mushroom logs were examined. Size reduction of normal wood (145 kW h/tone) required significantly higher energy consumption than waste mushroom logs (70 kW h/tone). The crystallinity value of waste mushroom logs was dramatically lower (33%) than normal wood (49%) after cultivation by Lentinus edodes as spawn. Lignin, an enzymatic hydrolysis inhibitor in sugar production, decreased from 21.07% to 18.78% after inoculation of L. edodes. Total sugar yields obtained by enzyme and acid hydrolysis were higher in waste mushroom logs than in normal wood. After 24h fermentation, 12 g/L ethanol was produced on waste mushroom logs, while normal wood produced 8 g/L ethanol. These results indicate that waste mushroom logs are economically suitable lignocellulosic material for the production of fermentable sugars related to bioethanol production.

Evaluation of borehole geophysical and video logs, at Butz Landfill Superfund Site, Jackson Township, Monroe County, Pennsylvania

USGS Publications Warehouse

Low, Dennis J.; Conger, Randall W.

2001-01-01

Between February 1996 and November 2000, geophysical logging was conducted in 27 open borehole wells in and adjacent to the Butz Landfill Superfund Site, Jackson Township, Monroe County, Pa., to determine casing depth and depths of water-producing zones, water-receiving zones, and zones of vertical borehole flow. The wells range in depth from 57 to 319 feet below land surface. The geophysical logging determined the placement of well screens and packers, which allow monitoring and sampling of water-bearing zones in the fractured bedrock so that the horizontal and vertical distribution of contaminated ground water migrating from known sources could be determined. Geophysical logging included collection of caliper, natural-gamma, single-point-resistance, fluid-resistivity, fluid-temperature, and video logs. Caliper and video logs were used to locate fractures, joints, and weathered zones. Inflections on single-point-resistance, fluid-temperature, and fluid-resistivity logs indicated possible water-bearing fractures, and heatpulse-flowmeter measurements verified these locations. Natural-gamma logs provided information on stratigraphy.

Reconciling timber extraction with biodiversity conservation in tropical forests using reduced-impact logging

PubMed Central

Bicknell, Jake E; Struebig, Matthew J; Davies, Zoe G; Baraloto, Christopher

2015-01-01

Over 20% of the world's tropical forests have been selectively logged, and large expanses are allocated for future timber extraction. Reduced-impact logging (RIL) is being promoted as best practice forestry that increases sustainability and lowers CO2 emissions from logging, by reducing collateral damage associated with timber extraction. RIL is also expected to minimize the impacts of selective logging on biodiversity, although this is yet to be thoroughly tested. We undertake the most comprehensive study to date to investigate the biodiversity impacts of RIL across multiple taxonomic groups. We quantified birds, bats and large mammal assemblage structures, using a before-after control-impact (BACI) design across 20 sample sites over a 5-year period. Faunal surveys utilized point counts, mist nets and line transects and yielded >250 species. We examined assemblage responses to logging, as well as partitions of feeding guild and strata (understorey vs. canopy), and then tested for relationships with logging intensity to assess the primary determinants of community composition. Community analysis revealed little effect of RIL on overall assemblages, as structure and composition were similar before and after logging, and between logging and control sites. Variation in bird assemblages was explained by natural rates of change over time, and not logging intensity. However, when partitioned by feeding guild and strata, the frugivorous and canopy bird ensembles changed as a result of RIL, although the latter was also associated with change over time. Bats exhibited variable changes post-logging that were not related to logging, whereas large mammals showed no change at all. Indicator species analysis and correlations with logging intensities revealed that some species exhibited idiosyncratic responses to RIL, whilst abundance change of most others was associated with time. Synthesis and applications. Our study demonstrates the relatively benign effect of reduced-impact logging (RIL) on birds, bats and large mammals in a neotropical forest context, and therefore, we propose that forest managers should improve timber extraction techniques more widely. If RIL is extensively adopted, forestry concessions could represent sizeable and important additions to the global conservation estate – over 4 million km2. PMID:25954054

Fatigue Shifts and Scatters Heart Rate Variability in Elite Endurance Athletes

PubMed Central

Schmitt, Laurent; Regnard, Jacques; Desmarets, Maxime; Mauny, Fréderic; Mourot, Laurent; Fouillot, Jean-Pierre; Coulmy, Nicolas; Millet, Grégoire

2013-01-01

Purpose This longitudinal study aimed at comparing heart rate variability (HRV) in elite athletes identified either in ‘fatigue’ or in ‘no-fatigue’ state in ‘real life’ conditions. Methods 57 elite Nordic-skiers were surveyed over 4 years. R-R intervals were recorded supine (SU) and standing (ST). A fatigue state was quoted with a validated questionnaire. A multilevel linear regression model was used to analyze relationships between heart rate (HR) and HRV descriptors [total spectral power (TP), power in low (LF) and high frequency (HF) ranges expressed in ms2 and normalized units (nu)] and the status without and with fatigue. The variables not distributed normally were transformed by taking their common logarithm (log10). Results 172 trials were identified as in a ‘fatigue’ and 891 as in ‘no-fatigue’ state. All supine HR and HRV parameters (Beta±SE) were significantly different (P<0.0001) between ‘fatigue’ and ‘no-fatigue’: HRSU (+6.27±0.61 bpm), logTPSU (−0.36±0.04), logLFSU (−0.27±0.04), logHFSU (−0.46±0.05), logLF/HFSU (+0.19±0.03), HFSU(nu) (−9.55±1.33). Differences were also significant (P<0.0001) in standing: HRST (+8.83±0.89), logTPST (−0.28±0.03), logLFST (−0.29±0.03), logHFST (−0.32±0.04). Also, intra-individual variance of HRV parameters was larger (P<0.05) in the ‘fatigue’ state (logTPSU: 0.26 vs. 0.07, logLFSU: 0.28 vs. 0.11, logHFSU: 0.32 vs. 0.08, logTPST: 0.13 vs. 0.07, logLFST: 0.16 vs. 0.07, logHFST: 0.25 vs. 0.14). Conclusion HRV was significantly lower in 'fatigue' vs. 'no-fatigue' but accompanied with larger intra-individual variance of HRV parameters in 'fatigue'. The broader intra-individual variance of HRV parameters might encompass different changes from no-fatigue state, possibly reflecting different fatigue-induced alterations of HRV pattern. PMID:23951198

Influence of logging on the effects of wildfire in Siberia

NASA Astrophysics Data System (ADS)

Kukavskaya, E. A.; Buryak, L. V.; Ivanova, G. A.; Conard, S. G.; Kalenskaya, O. P.; Zhila, S. V.; McRae, D. J.

2013-12-01

The Russian boreal zone supports a huge terrestrial carbon pool. Moreover, it is a tremendous reservoir of wood products concentrated mainly in Siberia. The main natural disturbance in these forests is wildfire, which modifies the carbon budget and has potentially important climate feedbacks. In addition, both legal and illegal logging increase landscape complexity and affect burning conditions and fuel consumption. We investigated 100 individual sites with different histories of logging and fire on a total of 23 study areas in three different regions of Siberia to evaluate the impacts of fire and logging on fuel loads, carbon emissions, and tree regeneration in pine and larch forests. We found large variations of fire and logging effects among regions depending on growing conditions and type of logging activity. Logged areas in the Angara region had the highest surface and ground fuel loads (up to 135 t ha-1), mainly due to logging debris. This resulted in high carbon emissions where fires occurred on logged sites (up to 41 tC ha-1). The Shushenskoe/Minusinsk and Zabaikal regions are characterized by better slash removal and a smaller amount of carbon emitted to the atmosphere during fires. Illegal logging, which is widespread in the Zabaikal region, resulted in an increase in fire hazard and higher carbon emissions than legal logging. The highest fuel loads (on average 108 t ha-1) and carbon emissions (18-28 tC ha-1) in the Zabaikal region are on repeatedly burned unlogged sites where trees fell on the ground following the first fire event. Partial logging in the Shushenskoe/Minusinsk region has insufficient impact on stand density, tree mortality, and other forest conditions to substantially increase fire hazard or affect carbon stocks. Repeated fires on logged sites resulted in insufficient tree regeneration and transformation of forest to grasslands. We conclude that negative impacts of fire and logging on air quality, the carbon cycle, and ecosystem sustainability could be decreased by better slash removal in the Angara region, removal of trees killed by fire in the Zabaikal region, and tree planting after fires in drier conditions where natural regeneration is hampered by soil overheating and grass proliferation.

Selective‐logging and oil palm: multitaxon impacts, biodiversity indicators, and trade‐offs for conservation planning.

PubMed

Edwards, David P; Magrach, Ainhoa; Woodcock, Paul; Ji, Yinqiu; Lim, Norman T -L; Edwards, Felicity A; Larsen, Trond H; Hsu, Wayne W; Benedick, Suzan; Khen, Chey Vun; Chung, Arthur Y C; Reynolds, Glen; Fisher, Brendan; Laurance, William F; Wilcove, David S; Hamer, Keith C; Yu, Douglas W

Strong global demand for tropical timber and agricultural products has driven large-scale logging and subsequent conversion of tropical forests. Given that the majority of tropical landscapes have been or will likely be logged, the protection of biodiversity within tropical forests thus depends on whether species can persist in these economically exploited lands, and if species cannot persist, whether we can protect enough primary forest from logging and conversion. However, our knowledge of the impact of logging and conversion on biodiversity is limited to a few taxa, often sampled in different locations with complex land-use histories, hampering attempts to plan cost-effective conservation strategies and to draw conclusions across taxa. Spanning a land-use gradient of primary forest, once- and twice-logged forests, and oil palm plantations, we used traditional sampling and DNA metabarcoding to compile an extensive data set in Sabah, Malaysian Borneo for nine vertebrate and invertebrate taxa to quantify the biological impacts of logging and oil palm, develop cost-effective methods of protecting biodiversity, and examine whether there is congruence in response among taxa. Logged forests retained high species richness, including, on average, 70% of species found in primary forest. In contrast, conversion to oil palm dramatically reduces species richness, with significantly fewer primary-forest species than found on logged forest transects for seven taxa. Using a systematic conservation planning analysis, we show that efficient protection of primary-forest species is achieved with land portfolios that include a large proportion of logged-forest plots. Protecting logged forests is thus a cost-effective method of protecting an ecologically and taxonomically diverse range of species, particularly when conservation budgets are limited. Six indicator groups (birds, leaf-litter ants, beetles, aerial hymenopterans, flies, and true bugs) proved to be consistently good predictors of the response of the other taxa to logging and oil palm. Our results confidently establish the high conservation value of logged forests and the low value of oil palm. Cross-taxon congruence in responses to disturbance also suggests that the practice of focusing on key indicator taxa yields important information of general biodiversity in studies of logging and oil palm.

VizieR Online Data Catalog: CoRoT red giants abundances (Morel+, 2014)

NASA Astrophysics Data System (ADS)

Morel, T.; Miglio, A.; Lagarde, N.; Montalban, J.; Rainer, M.; Poretti, E.; Eggenberger, P.; Hekker, S.; Kallinger, T.; Mosser, B.; Valentini, M.; Carrier, F.; Hareter, M.; Mantegazza, L.

2014-02-01

The equivalent widths were measured manually assuming Gaussian profiles or Voigt profiles for the few lines with extended damping wings. Lines with an unsatisfactory fit or significantly affected by telluric features were discarded. Only values eventually retained for the analysis are provided. For the chemical abundances, the usual notation is used: [X/Y]=[log({epsilon}(X))-log({epsilon}(Y))]star - [log({epsilon}(X))-log({epsilon}(Y))]⊙ with log{epsilon}(X)=12+log[N(X)/N(H)] (N is the number density of the species). For lithium, the following notation is used: [Li/H]=log(N(Li))star-log(N(Li))⊙. The adopted solar abundances are taken from Grevesse & Sauval (1998SSRv...85..161G), except for Li for which we adopt our derived values: log({epsilon}(Li))⊙=1.09 and 1.13 in LTE and NLTE, respectively (see text). All the abundances are computed under the assumption of LTE, except Li for which values corrected for departures from LTE using the data of Lind et al. (2009A&A...503..541L) are also provided. All the quoted error bars are 1-sigma uncertainties. (6 data files).

Effects of logging and recruitment on community phylogenetic structure in 32 permanent forest plots of Kampong Thom, Cambodia

PubMed Central

Toyama, Hironori; Kajisa, Tsuyoshi; Tagane, Shuichiro; Mase, Keiko; Chhang, Phourin; Samreth, Vanna; Ma, Vuthy; Sokh, Heng; Ichihashi, Ryuji; Onoda, Yusuke; Mizoue, Nobuya; Yahara, Tetsukazu

2015-01-01

Ecological communities including tropical rainforest are rapidly changing under various disturbances caused by increasing human activities. Recently in Cambodia, illegal logging and clear-felling for agriculture have been increasing. Here, we study the effects of logging, mortality and recruitment of plot trees on phylogenetic community structure in 32 plots in Kampong Thom, Cambodia. Each plot was 0.25 ha; 28 plots were established in primary evergreen forests and four were established in secondary dry deciduous forests. Measurements were made in 1998, 2000, 2004 and 2010, and logging, recruitment and mortality of each tree were recorded. We estimated phylogeny using rbcL and matK gene sequences and quantified phylogenetic α and β diversity. Within communities, logging decreased phylogenetic diversity, and increased overall phylogenetic clustering and terminal phylogenetic evenness. Between communities, logging increased phylogenetic similarity between evergreen and deciduous plots. On the other hand, recruitment had opposite effects both within and between communities. The observed patterns can be explained by environmental homogenization under logging. Logging is biased to particular species and larger diameter at breast height, and forest patrol has been effective in decreasing logging. PMID:25561669

Application of borehole geophysics to water-resources investigations

USGS Publications Warehouse

Keys, W.S.; MacCary, L.M.

1971-01-01

This manual is intended to be a guide for hydrologists using borehole geophysics in ground-water studies. The emphasis is on the application and interpretation of geophysical well logs, and not on the operation of a logger. It describes in detail those logging techniques that have been utilized within the Water Resources Division of the U.S. Geological Survey, and those used in petroleum investigations that have potential application to hydrologic problems. Most of the logs described can be made by commercial logging service companies, and many can be made with small water-well loggers. The general principles of each technique and the rules of log interpretation are the same, regardless of differences in instrumentation. Geophysical well logs can be interpreted to determine the lithology, geometry, resistivity, formation factor, bulk density, porosity, permeability, moisture content, and specific yield of water-bearing rocks, and to define the source, movement, and chemical and physical characteristics of ground water. Numerous examples of logs are used to illustrate applications and interpretation in various ground-water environments. The interrelations between various types of logs are emphasized, and the following aspects are described for each of the important logging techniques: Principles and applications, instrumentation, calibration and standardization, radius of investigation, and extraneous effects.

Effects of logging and recruitment on community phylogenetic structure in 32 permanent forest plots of Kampong Thom, Cambodia.

PubMed

Toyama, Hironori; Kajisa, Tsuyoshi; Tagane, Shuichiro; Mase, Keiko; Chhang, Phourin; Samreth, Vanna; Ma, Vuthy; Sokh, Heng; Ichihashi, Ryuji; Onoda, Yusuke; Mizoue, Nobuya; Yahara, Tetsukazu

2015-02-19

Ecological communities including tropical rainforest are rapidly changing under various disturbances caused by increasing human activities. Recently in Cambodia, illegal logging and clear-felling for agriculture have been increasing. Here, we study the effects of logging, mortality and recruitment of plot trees on phylogenetic community structure in 32 plots in Kampong Thom, Cambodia. Each plot was 0.25 ha; 28 plots were established in primary evergreen forests and four were established in secondary dry deciduous forests. Measurements were made in 1998, 2000, 2004 and 2010, and logging, recruitment and mortality of each tree were recorded. We estimated phylogeny using rbcL and matK gene sequences and quantified phylogenetic α and β diversity. Within communities, logging decreased phylogenetic diversity, and increased overall phylogenetic clustering and terminal phylogenetic evenness. Between communities, logging increased phylogenetic similarity between evergreen and deciduous plots. On the other hand, recruitment had opposite effects both within and between communities. The observed patterns can be explained by environmental homogenization under logging. Logging is biased to particular species and larger diameter at breast height, and forest patrol has been effective in decreasing logging. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Serum Spot 14 concentration is negatively associated with thyroid-stimulating hormone level

PubMed Central

Chen, Yen-Ting; Tseng, Fen-Yu; Chen, Pei-Lung; Chi, Yu-Chao; Han, Der-Sheng; Yang, Wei-Shiung

2016-01-01

Abstract Spot 14 (S14) is a protein involved in fatty acid synthesis and was shown to be induced by thyroid hormone in rat liver. However, the presence of S14 in human serum and its relations with thyroid function status have not been investigated. The objectives of this study were to compare serum S14 concentrations in patients with hyperthyroidism or euthyroidism and to evaluate the associations between serum S14 and free thyroxine (fT4) or thyroid-stimulating hormone (TSH) levels. We set up an immunoassay for human serum S14 concentrations and compared its levels between hyperthyroid and euthyroid subjects. Twenty-six hyperthyroid patients and 29 euthyroid individuals were recruited. Data of all patients were pooled for the analysis of the associations between the levels of S14 and fT4, TSH, or quartile of TSH. The hyperthyroid patients had significantly higher serum S14 levels than the euthyroid subjects (median [Q1, Q3]: 975 [669, 1612] ng/mL vs 436 [347, 638] ng/mL, P < 0.001). In univariate linear regression, the log-transformed S14 level (logS14) was positively associated with fT4 but negatively associated with creatinine (Cre), total cholesterol (T-C), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and TSH. The positive associations between logS14 and fT4 and the negative associations between logS14 and Cre, TG, T-C, or TSH remained significant after adjustment with sex and age. These associations were prominent in females but not in males. The logS14 levels were negatively associated with the TSH levels grouped by quartile (ß = −0.3020, P < 0.001). The association between logS14 and TSH quartile persisted after adjustment with sex and age (ß = −0.2828, P = 0.001). In stepwise multivariate regression analysis, only TSH grouped by quartile remained significantly associated with logS14 level. We developed an ELISA to measure serum S14 levels in human. Female patients with hyperthyroidism had higher serum S14 levels than the female subjects with euthyroidism. The serum logS14 concentrations were negatively associated with TSH levels. Changes of serum S14 level in the whole thyroid function spectrum deserve further investigation. PMID:27749565

Optimizing Unmanned Aircraft System Scheduling

DTIC Science & Technology

2008-06-01

COL_MISSION_NAME)) If Trim( CStr (rMissions(iRow, COL_MISSION_REQUIRED))) <> "" Then If CLng(rMissions(iRow, COL_MISSION_REQUIRED)) > CLng...logFN, "s:" & CStr (s) & " " For iRow = 1 To top Print #logFN, stack(iRow) & "," Next iRow Print #logFN...340" 60 Print #logFN, "m:" & CStr (s) & " " For iRow = 1 To top Print #logFN, lMissionPeriod(iRow

Effects of selective logging on bat communities in the southeastern Amazon.

PubMed

Peters, Sandra L; Malcolm, Jay R; Zimmerman, Barbara L

2006-10-01

Although extensive areas of tropical forest are selectively logged each year, the responses of bat communities to this form of disturbance have rarely been examined. Our objectives were to (1) compare bat abundance, species composition, and feeding guild structure between unlogged and low-intensity selectively logged (1-4 logged stems/ha) sampling grids in the southeastern Amazon and (2) examine correlations between logging-induced changes in bat communities and forest structure. We captured bats in understory and canopy mist nets set in five 1-ha study grids in both logged and unlogged forest. We captured 996 individuals, representing 5 families, 32 genera, and 49 species. Abundances of nectarivorous and frugivorous taxa (Glossophaginae, Lonchophyllinae, Stenodermatinae, and Carolliinae) were higher at logged sites, where canopy openness and understory foliage density were greatest. In contrast, insectivorous and omnivorous species (Emballonuridae, Mormoopidae, Phyllostominae, and Vespertilionidae) were more abundant in unlogged sites, where canopy foliage density and variability in the understory stratum were greatest. Multivariate analyses indicated that understory bat species composition differed strongly between logged and unlogged sites but provided little evidence of logging effects for the canopy fauna. Different responses among feeding guilds and taxonomic groups appeared to be related to foraging and echolocation strategies and to changes in canopy cover and understory foliage densities. Our results suggest that even low-intensity logging modifies habitat structure, leading to changes in bat species composition.

Use of biopartitioning micellar chromatography and RP-HPLC for the determination of blood-brain barrier penetration of α-adrenergic/imidazoline receptor ligands, and QSPR analysis.

PubMed

Vucicevic, J; Popovic, M; Nikolic, K; Filipic, S; Obradovic, D; Agbaba, D

2017-03-01

For this study, 31 compounds, including 16 imidazoline/α-adrenergic receptor (IRs/α-ARs) ligands and 15 central nervous system (CNS) drugs, were characterized in terms of the retention factors (k) obtained using biopartitioning micellar and classical reversed phase chromatography (log k BMC and log k wRP , respectively). Based on the retention factor (log k wRP ) and slope of the linear curve (S) the isocratic parameter (φ 0 ) was calculated. Obtained retention factors were correlated with experimental log BB values for the group of examined compounds. High correlations were obtained between logarithm of biopartitioning micellar chromatography (BMC) retention factor and effective permeability (r(log k BMC /log BB): 0.77), while for RP-HPLC system the correlations were lower (r(log k wRP /log BB): 0.58; r(S/log BB): -0.50; r(φ 0 /P e ): 0.61). Based on the log k BMC retention data and calculated molecular parameters of the examined compounds, quantitative structure-permeability relationship (QSPR) models were developed using partial least squares, stepwise multiple linear regression, support vector machine and artificial neural network methodologies. A high degree of structural diversity of the analysed IRs/α-ARs ligands and CNS drugs provides wide applicability domain of the QSPR models for estimation of blood-brain barrier penetration of the related compounds.

The impact of logging on biodiversity and carbon sequestration in tropical forests

NASA Astrophysics Data System (ADS)

Cazzolla Gatti, R.

2012-04-01

Tropical deforestation is one of the most relevant environmental issues at planetary scale. Forest clearcutting has dramatic effect on local biodiversity, on the terrestrial carbon sink and atmospheric GHGs balance. In terms of protection of tropical forests selective logging is, instead, often regarded as a minor or even positive management practice for the ecosystem and it is supported by international certifications. However, few studies are available on changes in the structure, biodiversity and ecosystem services due to the selective logging of African forests. This paper presents the results of a survey on tropical forests of West and Central Africa, with a comparison of long-term dynamics, structure, biodiversity and ecosystem services (such as the carbon sequestration) of different types of forests, from virgin primary to selectively logged and secondary forest. Our study suggests that there is a persistent effect of selective logging on biodiversity and carbon stock losses in the long term (up to 30 years since logging) and after repeated logging. These effects, in terms of species richness and biomass, are greater than the expected losses from commercial harvesting, implying that selective logging in West and Central Africa is impairing long term (at least until 30 years) ecosystem structure and services. A longer selective logging cycle (>30 years) should be considered by logging companies although there is not yet enough information to consider this practice sustainable.

Prediction of gas/particle partitioning of polybrominated diphenyl ethers (PBDEs) in global air: a theoretical study

NASA Astrophysics Data System (ADS)

Li, Y.-F.; Ma, W.-L.; Yang, M.

2014-09-01

Gas/particle (G / P) partitioning for most semivolatile organic compounds (SVOCs) is an important process that primarily governs their atmospheric fate, long-range atmospheric transport potential, and their routs to enter human body. All previous studies on this issue have been hypothetically derived from equilibrium conditions, the results of which do not predict results from monitoring studies well in most cases. In this study, a steady-state model instead of an equilibrium-state model for the investigation of the G / P partitioning behavior for polybrominated diphenyl ethers (PBDEs) was established, and an equation for calculating the partition coefficients under steady state (KPS) for PBDE congeners (log KPS = log KPE + logα) was developed, in which an equilibrium term (log KPE = log KOA + logfOM -11.91, where fOM is organic matter content of the particles) and a nonequilibrium term (logα, mainly caused by dry and wet depositions of particles), both being functions of log KOA (octanol-air partition coefficient), are included, and the equilibrium is a special case of steady state when the nonequilibrium term equals to zero. A criterion to classify the equilibrium and nonequilibrium status for PBDEs was also established using two threshold values of log KOA, log KOA1 and log KOA2, which divide the range of log KOA into 3 domains: equilibrium, nonequilibrium, and maximum partition domains; and accordingly, two threshold values of temperature t, tTH1 when log KOA = log KOA1 and tTH2 when log KOA = log KOA2, were identified, which divide the range of temperature also into the same 3 domains for each BDE congener. We predicted the existence of the maximum partition domain (the values of log KPS reach a maximum constant of -1.53) that every PBDE congener can reach when log KOA ≥ log KOA2, or t ≤ tTH2. The novel equation developed in this study was applied to predict the G / P partition coefficients of PBDEs for the published monitoring data worldwide, including Asia, Europe, North America, and the Arctic, and the results matched well with all the monitoring data, except those obtained at e-waste sites due to the unpredictable PBDE emissions at these sites. This study provided evidence that, the new developed steady-state-based equation is superior to the equilibrium-state-based equation that has been used in describing the G / P partitioning behavior in decades. We suggest that, the investigation on G / P partitioning behavior for PBDEs should be based on steady state, not equilibrium state, and equilibrium is just a special case of steady state when nonequilibrium factors can be ignored. We also believe that our new equation provides a useful tool for environmental scientists in both monitoring and modeling research on G / P partitioning for PBDEs and can be extended to predict G / P partitioning behavior for other SVOCs as well.

The impact of logging roads on dung beetle assemblages in a tropical rainforest reserve.

PubMed

Edwards, Felicity A; Finan, Jessica; Graham, Lucy K; Larsen, Trond H; Wilcove, David S; Hsu, Wayne W; Chey, V K; Hamer, Keith C

2017-01-01

The demand for timber products is facilitating the degradation and opening up of large areas of intact habitats rich in biodiversity. Logging creates an extensive network of access roads within the forest, yet these are commonly ignored or excluded when assessing impacts of logging on forest biodiversity. Here we determine the impact of these roads on the overall condition of selectively logged forests in Borneo, Southeast Asia. Focusing on dung beetles along > 40 km logging roads we determine: (i) the magnitude and extent of edge effects alongside logging roads; (ii) whether vegetation characteristics can explain patterns in dung beetle communities, and; (iii) how the inclusion of road edge forest impacts dung beetle assemblages within the overall logged landscape. We found that while vegetation structure was significantly affected up to 34 m from the road edge, impacts on dung beetle communities penetrated much further and were discernible up to 170 m into the forest interior. We found larger species and particularly tunnelling species responded more than other functional groups which were also influenced by micro-habitat variation. We provide important new insights into the long-term ecological impacts of tropical logging. We also support calls for improved logging road design both during and after timber extraction to conserve more effectively biodiversity in production forests, for instance, by considering the minimum volume of timber, per unit length of logging road needed to justify road construction. In particular, we suggest that governments and certification bodies need to highlight more clearly the biodiversity and environmental impacts of logging roads.

Operator product expansion in Liouville field theory and Seiberg-type transitions in log-correlated random energy models

NASA Astrophysics Data System (ADS)

Cao, Xiangyu; Le Doussal, Pierre; Rosso, Alberto; Santachiara, Raoul

2018-04-01

We study transitions in log-correlated random energy models (logREMs) that are related to the violation of a Seiberg bound in Liouville field theory (LFT): the binding transition and the termination point transition (a.k.a., pre-freezing). By means of LFT-logREM mapping, replica symmetry breaking and traveling-wave equation techniques, we unify both transitions in a two-parameter diagram, which describes the free-energy large deviations of logREMs with a deterministic background log potential, or equivalently, the joint moments of the free energy and Gibbs measure in logREMs without background potential. Under the LFT-logREM mapping, the transitions correspond to the competition of discrete and continuous terms in a four-point correlation function. Our results provide a statistical interpretation of a peculiar nonlocality of the operator product expansion in LFT. The results are rederived by a traveling-wave equation calculation, which shows that the features of LFT responsible for the transitions are reproduced in a simple model of diffusion with absorption. We examine also the problem by a replica symmetry breaking analysis. It complements the previous methods and reveals a rich large deviation structure of the free energy of logREMs with a deterministic background log potential. Many results are verified in the integrable circular logREM, by a replica-Coulomb gas integral approach. The related problem of common length (overlap) distribution is also considered. We provide a traveling-wave equation derivation of the LFT predictions announced in a precedent work.

Determination of reversed-phase high performance liquid chromatography based octanol-water partition coefficients for neutral and ionizable compounds: Methodology evaluation.

PubMed

Liang, Chao; Qiao, Jun-Qin; Lian, Hong-Zhen

2017-12-15

Reversed-phase liquid chromatography (RPLC) based octanol-water partition coefficient (logP) or distribution coefficient (logD) determination methods were revisited and assessed comprehensively. Classic isocratic and some gradient RPLC methods were conducted and evaluated for neutral, weak acid and basic compounds. Different lipophilicity indexes in logP or logD determination were discussed in detail, including the retention factor logk w corresponding to neat water as mobile phase extrapolated via linear solvent strength (LSS) model from isocratic runs and calculated with software from gradient runs, the chromatographic hydrophobicity index (CHI), apparent gradient capacity factor (k g ') and gradient retention time (t g ). Among the lipophilicity indexes discussed, logk w from whether isocratic or gradient elution methods best correlated with logP or logD. Therefore logk w is recommended as the preferred lipophilicity index for logP or logD determination. logk w easily calculated from methanol gradient runs might be the main candidate to replace logk w calculated from classic isocratic run as the ideal lipophilicity index. These revisited RPLC methods were not applicable for strongly ionized compounds that are hardly ion-suppressed. A previously reported imperfect ion-pair RPLC method was attempted and further explored for studying distribution coefficients (logD) of sulfonic acids that totally ionized in the mobile phase. Notably, experimental logD values of sulfonic acids were given for the first time. The IP-RPLC method provided a distinct way to explore logD values of ionized compounds. Copyright © 2017 Elsevier B.V. All rights reserved.

Lipophilicity affects the pharmacokinetics and toxicity of local anaesthetic agents administered by caudal block.

PubMed

Nava-Ocampo, Alejandro A; Bello-Ramírez, Angélica M

2004-01-01

1. Drugs administered into the epidural space by caudal block are cleared by means of a process potentially affected by the lipophilic character of the compounds. 2. In the present study, we examined the relationship between the octanol-water partition coefficient (log Poct) and the time to reach the maximum plasma drug concentration (tmax) of lignocaine, bupivacaine and ropivacaine administered by caudal block in paediatric patients. We also examined the relationship between log Poct and the toxicity of these local anaesthetic agents in experimental models. The tmax and toxicity data were obtained from the literature. 3. Ropivacaine, with a log Poct of 2.9, exhibited a tmax of 61.6 min. The tmax of lignocaine, with a log Poct of 2.4, and bupivacaine, with a log Poct of with 3.4, were approximately 50% shorter than ropivacaine. At log Poct of approximately 3.0, the toxicity of these local anaesthetic agents was substantially increased. The relationship between log Poct and the convulsive effect in dogs was similar to the relationship between log Poct and the lethal dose in sheep. 4. With local anaesthetic agents, it appears that the relationship between log Poct and drug transfer from the epidural space to the blood stream is parabolic, being the slowest rate of transference at log Poct 3.0. Toxicity, due to plasma availability of these local anaesthetic agents, seems to be increased at log Poct equal or higher than 3.0 secondary to the highest transfer from plasma into the central nervous system.

Introducing high performance distributed logging service for ACS

NASA Astrophysics Data System (ADS)

Avarias, Jorge A.; López, Joao S.; Maureira, Cristián; Sommer, Heiko; Chiozzi, Gianluca

2010-07-01

The ALMA Common Software (ACS) is a software framework that provides the infrastructure for the Atacama Large Millimeter Array and other projects. ACS, based on CORBA, offers basic services and common design patterns for distributed software. Every properly built system needs to be able to log status and error information. Logging in a single computer scenario can be as easy as using fprintf statements. However, in a distributed system, it must provide a way to centralize all logging data in a single place without overloading the network nor complicating the applications. ACS provides a complete logging service infrastructure in which every log has an associated priority and timestamp, allowing filtering at different levels of the system (application, service and clients). Currently the ACS logging service uses an implementation of the CORBA Telecom Log Service in a customized way, using only a minimal subset of the features provided by the standard. The most relevant feature used by ACS is the ability to treat the logs as event data that gets distributed over the network in a publisher-subscriber paradigm. For this purpose the CORBA Notification Service, which is resource intensive, is used. On the other hand, the Data Distribution Service (DDS) provides an alternative standard for publisher-subscriber communication for real-time systems, offering better performance and featuring decentralized message processing. The current document describes how the new high performance logging service of ACS has been modeled and developed using DDS, replacing the Telecom Log Service. Benefits and drawbacks are analyzed. A benchmark is presented comparing the differences between the implementations.

Behavioral responses of cotton mice (Peromyscus gossypinus) to large amounts of coarse woody debris.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinkleman, Travis M.

Hinkleman, Travis M. 2004. MS Thesis. Clemson University, Clemson, South Carolina. 62 pp. Coarse woody debris (CWD) is any log, snag, or downed branch >10 cm in diameter. As a major structural feature of forest ecosystems, CWD serves as an important habitat component for a variety of organisms. Rodents frequently use CWD for travel routes and daytime refugia. Although rodents are known to use CWD extensively and selectively, the use and selection of CWD by rodents may vary according to the abundance of CWD. The purpose of this project was to determine the effect of CWD abundance on the habitatmore » use patterns of a common terrestrial rodent, the cotton mouse (Peromyscus gossypinus). I tracked cotton mice with fluorescent pigments and radiotelemetry in 6 plots, situated in loblolly pine (Pinus taeda) stands, with manipulated levels of woody debris. Treatment plots had 6x the amount of woody debris as control plots. I determined log use and movement patterns from the paths produced by powder-tracking, and I identified daytime refugia by radio-tracking. Travel along logs was almost exclusively associated with the surface of logs (91%). The proportion of a movement path associated with logs was not the best predictor of path complexity; rather, the sex of the individual was the only significant indicator of relative displacement (i.e., males moved farther from the point of release than females) and vegetation cover was the only significant predictor of mean turning angle (i.e., increasing vegetation cover yielded more convoluted paths). Mice used logs to a greater extent on treatment plots (23.7%) than mice on control plots (4.8%). Mice on treatment plots used logs with less decay, less ground contact, and more bark than logs used by mice on control plots. Differences in log use patterns were largely a result of the attributes of available logs, but mice used logs selectively on treatment plots. Refuges were highly associated with woody debris, including refuges in rotting stumps (65%), root boles (13%), brush piles (8%), and logs (7%). Mice used different frequencies of refuge types between treatments; root bole and brush pile refuges were used more on treatment plots whereas stump and log refuges were used more on control plots. Refuge type, log volume, and tree basal area were significant predictors of refuge selection on control plots whereas refuge type and size were significant predictors of refuge selection on treatment plots. Refuges were significantly more dispersed on treatment plots. Mice used refuges more intensely and switched refuges less in the winter than the summer, regardless of woody debris abundance. The extensive and selective use of logs by cotton mice suggests that logs may be an important resource. However, logs are not a critical habitat component. Over half of the paths on control plots were not associated with logs, and logs were used infrequently as refuges. Nonetheless, refuges were highly associated with woody debris (e.g., stumps, root boles), which suggests that woody debris may be a critical habitat component.« less

Balloon logging with the inverted skyline

NASA Technical Reports Server (NTRS)

Mosher, C. F.

1975-01-01

There is a gap in aerial logging techniques that has to be filled. The need for a simple, safe, sizeable system has to be developed before aerial logging will become effective and accepted in the logging industry. This paper presents such a system designed on simple principles with realistic cost and ecological benefits.

Missouri timber industry--an assessment of timber product output and use.

Treesearch

W. Brad. Smith; Shelby Jones

1990-01-01

Discusses recent Missouri forest industry trends; production and receipts of saw logs; and production of charcoal, veneer logs, cooperage logs, and other products in 1987. Reports on logging residue, on wood and bark residue generated at primary wood-using mills, and on disposition of this residue.

Missouri timber industry--an assessment of timber product output and use, 1991.

Treesearch

Ronald L. Hackett; Shelby Jones; Ronald J. Piva

1993-01-01

Discusses recent Missouri forest industry trends; production and receipts of saw logs; and production of charcoal, veneer logs, cooperage logs, and other products in 1991. Reports on logging residue, on wood and bark residue generated at primary wood-using mills, and on disposition of this residue.

Financial and Economic Analysis of Reduced Impact Logging

Treesearch

Tom Holmes

2016-01-01

Concern regarding extensive damage to tropical forests resulting from logging increased dramatically after World War II when mechanized logging systems developed in industrialized countries were deployed in the tropics. As a consequence, tropical foresters began developing logging procedures that were more environmentally benign, and by the 1990s, these practices began...

Evaluation of electronic logging and gamma ray device for bridge boring interpretation.

DOT National Transportation Integrated Search

1971-07-01

Since shallow electric logging devices and gamma ray devices (for use in holes of less than 200 feet in depth) have recently been developed, it was the aim of this work to ascertain if correlation between electric logs and/or gamma ray logs and known...

Intensifying the Group Member's Experience Using the Group Log.

ERIC Educational Resources Information Center

Valine, Warren J.

1983-01-01

Presents the use of a group log in which members analyze the content and process of each session using a suggested format. The log promotes dialogue between the leader and each group member and involves members more fully in the group process. Feedback indicates the log is valuable. (JAC)

Tables for estimating skidder tire wear

Treesearch

Cleveland J. Biller; Cleveland J. Biller

1970-01-01

This book of tables was prepared to help the logging operator estimate how much a particular logging job will wear the tires on his rubber-wheeled skidders. This is an important element in the cost of a logging operation. The logging operator can translate these estimates of tire wear into a production cost.

Developments in Quantitative Structure-Activity Relationships (QSAR). A Review

DTIC Science & Technology

1976-07-01

hyphae Analogs Inhibition of s-Nitrostyrenes 20 84 Growth Botrytie -,inerea Inhibition of a-Nitrostyrenes 6 84 Grcwth Bovine hemoglobin Binding of...AspergiL us niger, phenyl methacrylates upon Ranse-nula awmat~a and RR’NCSS Na+ upon Botrytis cinerea conformed to the general equation 35. The equations...log II vs log kw *79 Botrytis cinerea , 41, 64 -lg! slgý,7 Bovine hemoglobin, 36 lg Elv o .,7 Bovine serum albumin, 36 - log iI vs log P, 79 - log JE

Motives of Log Schemes

NASA Astrophysics Data System (ADS)

Howell, Nicholas L.

This thesis introduces two notions of motive associated to a log scheme. We introduce a category of log motives a la Voevodsky, and prove that the embedding of Voevodsky motives is an equivalence, in particular proving that any homotopy-invariant cohomology theory of schemes extends uniquely to log schemes. In the case of a log smooth degeneration, we give an explicit construction of the motivic Albanese of the degeneration, and show that the Hodge realization of this construction gives the Albanese of the limit Hodge structure.

Tools and data acquisition of borehole geophysical logging for the Florida Power and Light Company Turkey Point Power Plant in support of a groundwater, surface-water, and ecological monitoring plan, Miami-Dade County, Florida

USGS Publications Warehouse

Wacker, Michael A.

2010-01-01

Borehole geophysical logs were obtained from selected exploratory coreholes in the vicinity of the Florida Power and Light Company Turkey Point Power Plant. The geophysical logging tools used and logging sequences performed during this project are summarized herein to include borehole logging methods, descriptions of the properties measured, types of data obtained, and calibration information.

Consolidation of Military Pay and Personnel Functions (Copper). Volume II

DTIC Science & Technology

1978-05-01

Inclusi Log In 3815 Sign 3815 To T.S ToPage 11-15-A12 1 1 -1-AlICOPPER From Pago 11-15-All Log 11TL In UTL Control Log From Page 11-15-AIO Today’s saing...and Annota 381 for Inclusi 381 Il-S-ll To Page 11-15-A12 i11-15_Al INE TK T38T SUflLUEOT From Page I1-15-All Log UTL In UTL Control Log Fro Po Pa 9 I-5

Development of Mechanistic Flexible Pavement Design Concepts for the Heavyweight F-15 Aircraft

DTIC Science & Technology

1986-01-01

UPON REPETITION - VERTICAL SUBGRADE STRAIN RESULTS 131 B-l AC TENSILE STRAIN VERSUS AC THICKNESS, VARYING GRANULAR BASE THICKNESS 204 B...Log SR - 0.8243 - .4095(Log TAg)(Log E*^) - .0110(TGR/Log TAC) ♦ . 0132 (ERi) - .3811(Log ERi) R2-.947 SEE-.0506 (1.124) R2-.923 SEE-.06 Log DO...Thickness. 204 lk^»-^>W »-» •■■*-»«.■■»-»*-!»*» »j(i »*Ä«**»«iutft^^*fij»Ä^»t’Äa*a<uiKajtfj»«iBym^j,Ä*^j’jifjauai**Ä: -**> -"> V \\X%M?J(fjtfJK

Downhole well log and core montages from the Mount Elbert Gas Hydrate Stratigraphic Test Well, Alaska North Slope

USGS Publications Warehouse

Collett, T.S.; Lewis, R.E.; Winters, W.J.; Lee, M.W.; Rose, K.K.; Boswell, R.M.

2011-01-01

The BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well was an integral part of an ongoing project to determine the future energy resource potential of gas hydrates on the Alaska North Slope. As part of this effort, the Mount Elbert well included an advanced downhole geophysical logging program. Because gas hydrate is unstable at ground surface pressure and temperature conditions, a major emphasis was placed on the downhole-logging program to determine the occurrence of gas hydrates and the in-situ physical properties of the sediments. In support of this effort, well-log and core data montages have been compiled which include downhole log and core-data obtained from the gas-hydrate-bearing sedimentary section in the Mount Elbert well. Also shown are numerous reservoir parameters, including gas-hydrate saturation and sediment porosity log traces calculated from available downhole well log and core data. ?? 2010.

Seasonal variation and partitioning of endocrine disrupting chemicals in waters and sediments of the Pearl River system, South China.

PubMed

Gong, Jian; Duan, Dandan; Yang, Yu; Ran, Yong; Chen, Diyun

2016-12-01

Endocrine disrupting chemicals (EDCs) were seasonally investigated in surface water, suspended particulate matter, and sediments of the Pearl River Delta (PRD), South China. EDC concentrations in the surface water were generally higher in the summer than in winter. The surface water in the investigated rivers was heavily contaminated by the phenolic xenoestrogens. Moreover, the in-situ log K soc and log K poc values and their regression with log K ow in the field experiments suggest that binding mechanisms other than hydrophobic interaction are present for the sedimentary organic carbon and particulate organic carbon (SOC/POC). The logK soc -logK ow and logK poc -logK ow regression analyses imply that higher complexity of nonhydrophobic interactions with EDCs is present on the SOC samples comparing with the POC samples, which is related to their different sources. Copyright © 2016 Elsevier Ltd. All rights reserved.

Latent log-linear models for handwritten digit classification.

PubMed

Deselaers, Thomas; Gass, Tobias; Heigold, Georg; Ney, Hermann

2012-06-01

We present latent log-linear models, an extension of log-linear models incorporating latent variables, and we propose two applications thereof: log-linear mixture models and image deformation-aware log-linear models. The resulting models are fully discriminative, can be trained efficiently, and the model complexity can be controlled. Log-linear mixture models offer additional flexibility within the log-linear modeling framework. Unlike previous approaches, the image deformation-aware model directly considers image deformations and allows for a discriminative training of the deformation parameters. Both are trained using alternating optimization. For certain variants, convergence to a stationary point is guaranteed and, in practice, even variants without this guarantee converge and find models that perform well. We tune the methods on the USPS data set and evaluate on the MNIST data set, demonstrating the generalization capabilities of our proposed models. Our models, although using significantly fewer parameters, are able to obtain competitive results with models proposed in the literature.

CT Imaging of Hardwood Logs for Lumber Production

Treesearch

Daniel L. Schmoldt; Pei Li; A. Lynn Abbott

1996-01-01

Hardwood sawmill operators need to improve the conversion of raw material (logs) into lumber. Internal log scanning provides detailed information that can aid log processors in improving lumber recovery. However, scanner data (i.e. tomographic images) need to be analyzed prior to presentation to saw operators. Automatic labeling of computer tomography (CT) images is...

Is it time to revisit the log-sort yard?

Treesearch

John Dramm; Gerry Jackson

2000-01-01

Log-sort yards provide better utilization and marketing with improved value recovery of currently available timber resources in North America. Log-sort yards provide many services in marketing wood and fiber by concentrating, merchandising, manufacturing, sorting, and adding value to logs. Such operations supply forest products firms with desired raw materials, which...

19 CFR 12.140 - Entry of softwood lumber products from Canada.

Code of Federal Regulations, 2010 CFR

2010-04-01

... lumber products first produced in the Maritime Provinces from logs originating in a non-Maritime Region will be the Region, as defined above, where the logs originated; and (ii) The Region of Origin of...’) from logs originating outside the Territories will be the Region where the logs originated. (7) SLA...

Keystroke Analysis: Reflections on Procedures and Measures

ERIC Educational Resources Information Center

Baaijen, Veerle M.; Galbraith, David; de Glopper, Kees

2012-01-01

Although keystroke logging promises to provide a valuable tool for writing research, it can often be difficult to relate logs to underlying processes. This article describes the procedures and measures that the authors developed to analyze a sample of 80 keystroke logs, with a view to achieving a better alignment between keystroke-logging measures…

Logging residue in Washington, Oregon, California: volume and characteristics.

Treesearch

James O. Howard

1973-01-01

This report makes available data on the volume and characteristics of logging residue resulting from 1969 logging operations in Oregon, Washington, and California. The results indicate highest volumes of logging residue are found in the Douglas-fir region of western Oregon and western Washington. Average gross volume of residue in this region ranged...

Primary forest products industry and timber use, Wisconsin, 1973.

Treesearch

James E. Blyth; Eugene F. Landt; James W. Whipple; Jerold T. Hahn

1976-01-01

Discusses recent Wisconsin forest industry trends; timber removals for industrial roundwood in 1973; production and receipts in 1973 of pulpwood, saw logs, veneer logs, and other industrial roundwood products. Shows trends in pulpwood and veneer log production and compares saw log production in 1967 and 1973. Discusses primary wood-using plant residue and its...

Forest canopy damage and recovery in reduced-impact and conventional selective logging in eastern Para, Brazil.

Treesearch

Rodrigo Pereira Jr.; Johan Zweedea; Gregory P. Asnerb; Keller; Michael

2002-01-01

We investigated ground and canopy damage and recovery following conventional logging and reduced-impact logging (RIL) of moist tropical forest in the eastern Amazon of Brazil. Paired conventional and RIL blocks were selectively logged with a harvest intensity of approximately 23 m3 ha

Potential impact of easing the log export restriction on the Tongass National Forest.

Treesearch

David R. Darr

1978-01-01

The potential of higher revenues in the log export market is constrained by possible reductions in prices associated with expanded supplies in the Japanese log market. Expanded log exports from the Tongass National Forest might force adjustments by existing cantmills, even under a partial easing of the export restriction.

78 FR 44957 - Agency Information Collection Activities: BioWatch Filter Holder Log, Filter Holder Log DHS Form...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-25

... DEPARTMENT OF HOMELAND SECURITY Agency Information Collection Activities: BioWatch Filter Holder Log, Filter Holder Log DHS Form 9500 AGENCY: Office of Health Affairs, DHS. ACTION: 60-Day Notice and....: Daniel Yereb, [email protected] 703- 647-8052. SUPPLEMENTARY INFORMATION: Following collection, the filter...

Configuration of Appalachian logging roads

Treesearch

John E. Baumgras; John E. Baumgras

1971-01-01

The configuration - the curvature and grade - of logging roads in southern Appalachia is seldom severe, according to a recent Forest Service study. To improve the efficiency of logging roads, we must first define the characteristics of these roads; and in this report we provide a quantitative description of the configuration of over 200 miles of logging roads.

The Effect of Mandatory Reading Logs on Children's Motivation to Read

ERIC Educational Resources Information Center

Pak, Sarah S.; Weseley, Allyson J.

2012-01-01

Reading logs have become a practice in many elementary schools. Although lack of autonomy undermines intrinsic motivation (Lepper, Greene, & Nisbett, 1973), no study has examined the effect of logs. Second and third-grade students (N = 112) were assigned either a mandatory or voluntary log and surveyed about their motivation to read at…

Standing timber coefficients for Indiana walnut log production.

Treesearch

James E. Blyth; Edwin Kallio; John C. Callahan

1969-01-01

If the volume of walnut veneer logs and saw logs received at processing plants from Indiana forests is known, conversion factors developed in this paper can be used to determine how much timber was cut to provide these logs and the kinds of timber that were cut (sawtimber, cull trees, trees on nonforest land, etc.).

How much scarification from summer logging?

Treesearch

David A. Marquis; John C. Bjorkbom

1960-01-01

Scarification of the soil creates seedbeds that are favorable for the establishment of both paper birch and yellow birch. Logging in the summer often has been recommended as a method of obtaining these seedbeds. However, our observations on experimental logging jobs have shown that logging alone does not provide scarification over enough of the area to assure...

LogSafe and Smart: Minnesota OSHA's LogSafe Program Takes Root.

ERIC Educational Resources Information Center

Honerman, James

1999-01-01

Logging is now the most dangerous U.S. occupation. The Occupational Safety and Health Administration (OSHA) developed specialized safety training for the logging industry but has been challenged to reach small operators. An OSHA-approved state program in Minnesota provides annual safety seminars to about two-thirds of the state's full-time…

Primary forest products industry and timber use, Michigan, 1972.

Treesearch

James E. Blyth; Allan H. Boelter; Carl W. Danielson

1975-01-01

Discusses recent Michigan forest industry trends; timber removals for industrial roundwood in 1972; production and receipts in 1972 of pulpwood, saw logs, veneer logs ,and other roundwood products. Shows trends in pulpwood and veneer-log production, and compares saw log production in 1969 and 1972. Discusses primary wood-using plant residue and its disposition.

Electronic Warfare M-on-N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis

DTIC Science & Technology

2017-04-12

LOGGING STREAM The goal of this report is to investigate logging of EW simulations not at the level of implementation in a database management ...differences of the logging stream and relational models.  A hierarchical navigation query style appears very natural for our application. Yet the

U.S. Hardwood sawmill log procurement practices

Treesearch

Adrienn Andersch; Iris Montague; Urs Buehlmann; Janice K. Wiedenbeck

2015-01-01

U.S. hardwood sawmill log procurement practices are evolving because of the recent economic recession, market and supply chain shifts, and changing landowner objectives, among other factors. The objective of this study was to characterize the log procurement practices of hardwood sawmills and to characterize the role that log brokers play in supplying the sawmill...

Stump-to-truck cable logging cost equations for young-growth douglas-fir

Treesearch

Chris B. LeDoux; Roger D. Fight; Tom L. Ortman

1986-01-01

Logging cost simulators and data from logging cost studies have been assembled and converted into a series of equations that can be used to estimate the cost of logging young-growth coastal Douglas-fir (Pseudotsuga menziesii [Mirb.] Franco var. menziesii) in mountainous terrain of the Pacific Northwest. These equations were...

Fuels planning: science synthesis and integration; economic uses fact sheet 07: markets and log prices

Treesearch

Rocky Mountain Research Station USDA Forest Service

2004-01-01

Markets and prices for logs vary widely across the West, fluctuating from place to place in response to regional variables and hauling costs. This fact sheet discusses those variables, locality of log markets, markets for low-value logs, and caveats to consider when using My Fuel Treatment Planner.

Selective logging in the Brazilian Amazon.

Treesearch

G. P. Asner; D. E. Knapp; E. N. Broadbent; P. J. C. Oliveira; M Keller; J. N. Silva

2005-01-01

Amazon deforestation has been measured by remote sensing for three decades. In comparison, selective logging has been mostly invisible to satellites. We developed a large-scale, high-resolution, automated remote-sensing analysis of selective logging in the top five timber-producing states of the Brazilian Amazon. Logged areas ranged from 12,075 to 19,823 square...

Technoeconomic analysis of conventional logging systems operating from stump to landing

Treesearch

Raymond L. Sarles; William G. Luppold; William G. Luppold

1986-01-01

Analyzes technical and economic factors for six conventional logging systems suitable for operation in eastern forests. Discusses financial risks and business implications for loggers investing in high-production, state-of-the-art logging systems. Provides logging contractors with information useful as a preliminary guide for selection of equipment and systems....

Why, What, and How to Log? Lessons from LISTEN

ERIC Educational Resources Information Center

Mostow, Jack; Beck, Joseph E.

2009-01-01

The ability to log tutorial interactions in comprehensive, longitudinal, fine-grained detail offers great potential for educational data mining--but what data is logged, and how, can facilitate or impede the realization of that potential. We propose guidelines gleaned over 15 years of logging, exploring, and analyzing millions of events from…

Subsurface recognition of oolitic facies in carbonate sequence: Exploration and development applications: Ste. Genevieve Formation (Mississippian), Illinois basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bandy, W.F.

1989-08-01

The oolitic grainstone facies of the Ste. Genevieve Limestone is a widespread and highly productive reservoir in the Illinois basin. However, exploration and development of these oolitic facies are hampered by the inability to recognize the reservoir on logs. In many areas, the only log data available are old wireline electric logs. Comparison of cores with log response in northern Lawrence field, Lawrence County, Illinois, indicates a subjective but predictable relationship between log signature and carbonate lithology. Two productive lithologies, dolomite and oolitic grainstone, display well-developed SP curves. However, resistivity response is greatest in dense limestone, less well developed inmore » oolitic grainstone, and poorly developed in dolomites. On gamma-ray logs, oolitic facies can be differentiated from dolomites by their lower radioactivity. Oolitic sands are most easily recognized on porosity logs, where their average porosity is 13.7%, only half the average porosity of dolomites. In a new well, the best information for subsequent offset and development of an oolitic reservoir is provided by porosity and dipmeter logs.« less

Contrast Invariant Interest Point Detection by Zero-Norm LoG Filter.

PubMed

Zhenwei Miao; Xudong Jiang; Kim-Hui Yap

2016-01-01

The Laplacian of Gaussian (LoG) filter is widely used in interest point detection. However, low-contrast image structures, though stable and significant, are often submerged by the high-contrast ones in the response image of the LoG filter, and hence are difficult to be detected. To solve this problem, we derive a generalized LoG filter, and propose a zero-norm LoG filter. The response of the zero-norm LoG filter is proportional to the weighted number of bright/dark pixels in a local region, which makes this filter be invariant to the image contrast. Based on the zero-norm LoG filter, we develop an interest point detector to extract local structures from images. Compared with the contrast dependent detectors, such as the popular scale invariant feature transform detector, the proposed detector is robust to illumination changes and abrupt variations of images. Experiments on benchmark databases demonstrate the superior performance of the proposed zero-norm LoG detector in terms of the repeatability and matching score of the detected points as well as the image recognition rate under different conditions.

Analysis of geophysical logs from six boreholes at Lariat Gulch, former U.S. Air Force site PJKS, Jefferson County, Colorado

USGS Publications Warehouse

Paillet, Frederick L.; Hodges, Richard E.; Corland, Barbara S.

2002-01-01

This report presents and describes geophysical logs for six boreholes in Lariat Gulch, a topographic gulch at the former U.S. Air Force site PJKS in Jefferson County near Denver, Colorado. Geophysical logs include gamma, normal resistivity, fluid-column temperature and resistivity, caliper, televiewer, and heat-pulse flowmeter. These logs were run in two boreholes penetrating only the Fountain Formation of Pennsylvanian and Permian age (logged to depths of about 65 and 570 feet) and in four boreholes (logged to depths of about 342 to 742 feet) penetrating mostly the Fountain Formation and terminating in Precambrian crystalline rock, which underlies the Fountain Formation. Data from the logs were used to identify fractures and bedding planes and to locate the contact between the two formations. The logs indicated few fractures in the boreholes and gave no indication of higher transmissivity in the contact zone between the two formations. Transmissivities for all fractures in each borehole were estimated to be less than 2 feet squared per day.

Extracting the Textual and Temporal Structure of Supercomputing Logs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jain, S; Singh, I; Chandra, A

2009-05-26

Supercomputers are prone to frequent faults that adversely affect their performance, reliability and functionality. System logs collected on these systems are a valuable resource of information about their operational status and health. However, their massive size, complexity, and lack of standard format makes it difficult to automatically extract information that can be used to improve system management. In this work we propose a novel method to succinctly represent the contents of supercomputing logs, by using textual clustering to automatically find the syntactic structures of log messages. This information is used to automatically classify messages into semantic groups via an onlinemore » clustering algorithm. Further, we describe a methodology for using the temporal proximity between groups of log messages to identify correlated events in the system. We apply our proposed methods to two large, publicly available supercomputing logs and show that our technique features nearly perfect accuracy for online log-classification and extracts meaningful structural and temporal message patterns that can be used to improve the accuracy of other log analysis techniques.« less

Condition and fate of logged forests in the Brazilian Amazon.

PubMed

Asner, Gregory P; Broadbent, Eben N; Oliveira, Paulo J C; Keller, Michael; Knapp, David E; Silva, José N M

2006-08-22

The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests would be cleared within 4 years after timber harvest. Across 2,030,637 km2 of the Brazilian Amazon from 1999 to 2004, at least 76% of all harvest practices resulted in high levels of canopy damage sufficient to leave forests susceptible to drought and fire. We found that 16+/-1% of selectively logged areas were deforested within 1 year of logging, with a subsequent annual deforestation rate of 5.4% for 4 years after timber harvests. Nearly all logging occurred within 25 km of main roads, and within that area, the probability of deforestation for a logged forest was up to four times greater than for unlogged forests. In combination, our results show that logging in the Brazilian Amazon is dominated by highly damaging operations, often followed rapidly by deforestation decades before forests can recover sufficiently to produce timber for a second harvest. Under the management regimes in effect at the time of our study in the Brazilian Amazon, selective logging would not be sustained.

Application of Fracture Distribution Prediction Model in Xihu Depression of East China Sea

NASA Astrophysics Data System (ADS)

Yan, Weifeng; Duan, Feifei; Zhang, Le; Li, Ming

2018-02-01

There are different responses on each of logging data with the changes of formation characteristics and outliers caused by the existence of fractures. For this reason, the development of fractures in formation can be characterized by the fine analysis of logging curves. The well logs such as resistivity, sonic transit time, density, neutron porosity and gamma ray, which are classified as conventional well logs, are more sensitive to formation fractures. In view of traditional fracture prediction model, using the simple weighted average of different logging data to calculate the comprehensive fracture index, are more susceptible to subjective factors and exist a large deviation, a statistical method is introduced accordingly. Combining with responses of conventional logging data on the development of formation fracture, a prediction model based on membership function is established, and its essence is to analyse logging data with fuzzy mathematics theory. The fracture prediction results in a well formation in NX block of Xihu depression through two models are compared with that of imaging logging, which shows that the accuracy of fracture prediction model based on membership function is better than that of traditional model. Furthermore, the prediction results are highly consistent with imaging logs and can reflect the development of cracks much better. It can provide a reference for engineering practice.

Condition and fate of logged forests in the Brazilian Amazon

PubMed Central

Asner, Gregory P.; Broadbent, Eben N.; Oliveira, Paulo J. C.; Keller, Michael; Knapp, David E.; Silva, José N. M.

2006-01-01

The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests would be cleared within 4 years after timber harvest. Across 2,030,637 km2 of the Brazilian Amazon from 1999 to 2004, at least 76% of all harvest practices resulted in high levels of canopy damage sufficient to leave forests susceptible to drought and fire. We found that 16 ± 1% of selectively logged areas were deforested within 1 year of logging, with a subsequent annual deforestation rate of 5.4% for 4 years after timber harvests. Nearly all logging occurred within 25 km of main roads, and within that area, the probability of deforestation for a logged forest was up to four times greater than for unlogged forests. In combination, our results show that logging in the Brazilian Amazon is dominated by highly damaging operations, often followed rapidly by deforestation decades before forests can recover sufficiently to produce timber for a second harvest. Under the management regimes in effect at the time of our study in the Brazilian Amazon, selective logging would not be sustained. PMID:16901980

The potential of woody waste biomass from the logging activity at the natural forest of Berau District, East Kalimantan

NASA Astrophysics Data System (ADS)

Sari, D. R.; Ariyanto

2018-04-01

The fifth principles of Sustainable Forest Management of the Forest Stewardship Council (FSC) is to encourage the efficient use of forest products and services to ensure economic viability and a wide range of environmental and social benefits, and one of the criteria is to minimize logging waste. Therefore, identification, calculations, and monitoring of logging waste should be done. The purpose of this study were to know the potential of logging waste in logging area and to know the estimated volume of waste based on the Annual Allowable Cut (AAC). This research was carried out at PT Karya Lestari, Berau District, East Kalimantan. It was found that the highest percentage of waste was in the form of the main trunk canopy, followed by the branches, stump, twigs and the rest of the bucking. It was also found that there was quite strong positive relationship between the volume of felled trees with its logging waste volume, and the estimated volume of logging waste based on AAC was 40,623 m3 per year. This result shows that the potential logging waste is high and it is recommended for the company to do logging on trees with small volumes or lower diameter class (40-89 cm).

Maintaining ecosystem resilience: functional responses of tree cavity nesters to logging in temperate forests of the Americas.

PubMed

Ibarra, José Tomás; Martin, Michaela; Cockle, Kristina L; Martin, Kathy

2017-06-30

Logging often reduces taxonomic diversity in forest communities, but little is known about how this biodiversity loss affects the resilience of ecosystem functions. We examined how partial logging and clearcutting of temperate forests influenced functional diversity of birds that nest in tree cavities. We used point-counts in a before-after-control-impact design to examine the effects of logging on the value, range, and density of functional traits in bird communities in Canada (21 species) and Chile (16 species). Clearcutting, but not partial logging, reduced diversity in both systems. The effect was much more pronounced in Chile, where logging operations removed critical nesting resources (large decaying trees), than in Canada, where decaying aspen Populus tremuloides were retained on site. In Chile, logging was accompanied by declines in species richness, functional richness (amount of functional niche occupied by species), community-weighted body mass (average mass, weighted by species densities), and functional divergence (degree of maximization of divergence in occupied functional niche). In Canada, clearcutting did not affect species richness but nevertheless reduced functional richness and community-weighted body mass. Although some cavity-nesting birds can persist under intensive logging operations, their ecosystem functions may be severely compromised unless future nest trees can be retained on logged sites.

Coagulation, flocculation, dissolved air flotation and filtration in the removal of Giardia spp. and Cryptosporidium spp. from water supply.

PubMed

Andreoli, Fernando César; Sabogal-Paz, Lyda Patricia

2017-11-15

Removing protozoa from a water supply using coagulation, flocculation, dissolved air flotation (DAF) and filtration on a bench scale was evaluated. Calcium carbonate flocculation with and without immunomagnetic separation (IMS) was chosen to detect Giardia spp. cysts and Cryptosporidium spp. oocysts in the studied samples. The results indicated that DAF removed between 1.31 log and 1.79 log of cysts and between 1.08 log and 1.42 log of oocysts. The performance was lower in filtration, with the removal of 1.07 log-1.44 log for cysts and 0.82 log-0.98 log for oocysts. The coagulation, flocculation, DAF and filtration steps removed more than 2.2 log of cysts and oocysts from the water studied. However, protozoa were detected in the filtered water, even with turbidity values of 0.2 NTU. The recovery of the detection method met the international criteria and was higher when there was no IMS. Including the third acid dissociation in the IMS was critical to improve the performance of the protocol tested. However, there was an increase in the technical and analytical complexity and costs. It was also observed that the efficiency of the treatment was linked to the performance of the selected method of detecting protozoa.

Utilization of a reminder mailing to improve blood glucose log reporting in an outpatient diabetes clinic.

PubMed

Moorman, John M; Frazee, Lawrence A; Dillon, Melanie L; Chomo, Diane L; Myers, Nancy A

2012-07-01

Self-monitored blood glucose (SMBG) offers a strategy used to achieve glycemic control in diabetic patients. However, if SMBG readings are unavailable to clinicians, this strategy will have a limited effect. This study assessed the impact of a reminder mailing on response rates to requests for SMBG logs. Patients were asked to mail completed SMBG logs to the clinic in 2 weeks. For the intervention, a reminder mailing was sent to each patient 1 week before SMBG logs were to be returned. Compliance rates pre and postinterventions were compared. The primary outcome was the percentage of all SMBG logs returned on time. Secondary outcomes included the percentage of SMBG logs returned, percentage fulfilled, percentage of clinic appointments kept, percentage of SMBG logs brought to follow-up appointments, and number of interventions made to antidiabetic therapy. Twenty SMBG requests were made in the preintervention cohort versus 19 in postintervention cohort. A trend toward more on time and fulfilled SMBG requests was observed post vs. preintervention. Overall return rates were similar between groups. A nonsignificant increase in clinic appointments kept and a nonsignificant decrease in interventions made were observed postintervention. Receipt of a reminder mail was not a significant predictor of patients bringing an SMBG log to follow-up appointments. In conclusion, the use of a reminder mail was not associated with an increase in the return rate of SMBG logs, although there were nonsignificant trends toward more on time and fulfilled SMBG logs received during the postintervention period.

Construction and validation of a Tamil logMAR chart.

PubMed

Varadharajan, Srinivasa; Srinivasan, Krithica; Kumaresan, Brindha

2009-09-01

To design, construct and validate a new Tamil logMAR visual acuity chart based on current recommendations. Ten Tamil letters of equal legibility were identified experimentally and were used in the chart. Two charts, one internally illuminated and one externally illuminated, were constructed for testing at 4 m distance. The repeatability of the two charts was tested. For validation, the two charts were compared with a standard English logMAR chart (ETDRS). When compared to the ETDRS chart, a difference of 0.06 +/- 0.07 and 0.07 +/- 0.07 logMAR was found for the internally and externally illuminated charts respectively. Limits of agreement between the internally illuminated Tamil logMAR chart and ETDRS chart were found to be (-0.08, 0.19), and (-0.07, 0.20) for the externally illuminated chart. The test - retest results showed a difference of 0.02 +/- 0.04 and 0.02 +/- 0.06 logMAR for the internally and externally illuminated charts respectively. Limits of agreement for repeated measurements for the internally illuminated Tamil logMAR chart were found to be (-0.06, 0.10), and (-0.10, 0.14) for the externally illuminated chart. The newly constructed Tamil logMAR charts have good repeatability. The difference in visual acuity scores between the newly constructed Tamil logMAR chart and the standard English logMAR chart was within acceptable limits. This new chart can be used for measuring visual acuity in the literate Tamil population.

Automated method for measuring the extent of selective logging damage with airborne LiDAR data

NASA Astrophysics Data System (ADS)

Melendy, L.; Hagen, S. C.; Sullivan, F. B.; Pearson, T. R. H.; Walker, S. M.; Ellis, P.; Kustiyo; Sambodo, Ari Katmoko; Roswintiarti, O.; Hanson, M. A.; Klassen, A. W.; Palace, M. W.; Braswell, B. H.; Delgado, G. M.

2018-05-01

Selective logging has an impact on the global carbon cycle, as well as on the forest micro-climate, and longer-term changes in erosion, soil and nutrient cycling, and fire susceptibility. Our ability to quantify these impacts is dependent on methods and tools that accurately identify the extent and features of logging activity. LiDAR-based measurements of these features offers significant promise. Here, we present a set of algorithms for automated detection and mapping of critical features associated with logging - roads/decks, skid trails, and gaps - using commercial airborne LiDAR data as input. The automated algorithm was applied to commercial LiDAR data collected over two logging concessions in Kalimantan, Indonesia in 2014. The algorithm results were compared to measurements of the logging features collected in the field soon after logging was complete. The automated algorithm-mapped road/deck and skid trail features match closely with features measured in the field, with agreement levels ranging from 69% to 99% when adjusting for GPS location error. The algorithm performed most poorly with gaps, which, by their nature, are variable due to the unpredictable impact of tree fall versus the linear and regular features directly created by mechanical means. Overall, the automated algorithm performs well and offers significant promise as a generalizable tool useful to efficiently and accurately capture the effects of selective logging, including the potential to distinguish reduced impact logging from conventional logging.

Gulf of Mexico Gas Hydrate Joint Industry Project Leg II logging-while-drilling data acquisition and anaylsis

USGS Publications Warehouse

Collett, Timothy S.; Lee, Myung W.; Zyrianova, Margarita V.; Mrozewski, Stefan A.; Guerin, Gilles; Cook, Ann E.; Goldberg, Dave S.

2012-01-01

One of the objectives of the Gulf of MexicoGasHydrateJointIndustryProjectLegII (GOM JIP LegII) was the collection of a comprehensive suite of logging-while-drilling (LWD) data within gas-hydrate-bearing sand reservoirs in order to make accurate estimates of the concentration of gashydrates under various geologic conditions and to understand the geologic controls on the occurrence of gashydrate at each of the sites drilled during this expedition. The LWD sensors just above the drill bit provided important information on the nature of the sediments and the occurrence of gashydrate. There has been significant advancements in the use of downhole well-logging tools to acquire detailed information on the occurrence of gashydrate in nature: From using electrical resistivity and acoustic logs to identify gashydrate occurrences in wells to where wireline and advanced logging-while-drilling tools are routinely used to examine the petrophysical nature of gashydrate reservoirs and the distribution and concentration of gashydrates within various complex reservoir systems. Recent integrated sediment coring and well-log studies have confirmed that electrical resistivity and acoustic velocity data can yield accurate gashydrate saturations in sediment grain supported (isotropic) systems such as sand reservoirs, but more advanced log analysis models are required to characterize gashydrate in fractured (anisotropic) reservoir systems. In support of the GOM JIP LegII effort, well-log data montages have been compiled and presented in this report which includes downhole logs obtained from all seven wells drilled during this expedition with a focus on identifying and characterizing the potential gas-hydrate-bearing sedimentary section in each of the wells. Also presented and reviewed in this report are the gas-hydrate saturation and sediment porosity logs for each of the wells as calculated from available downhole well logs.

Evaluation of consumable household products for decontaminating retail skinless, boneless chicken breasts.

PubMed

McKee, L H; Neish, L; Pottenger, A; Flores, N; Weinbrenner, K; Remmenga, M

2005-03-01

The effect of 15 consumable products, including juices, wines, and vinegar, used as rinsing agents on microbial loads of retail skinless, boneless chicken breasts was evaluated in two studies. Ten breasts were rinsed for 1 min with each solution. Samples were swabbed before and after rinsing with a cellulose sponge and evaluated for total aerobic (APC), total coliform (TCC), and generic Escherichia coli counts by Petrifilm methods. No differences were found in initial APC or TCC in either study, with initial mean APC ranging from 5.30 to 7.05 log CFU/cm2 and initial mean TCC ranging from 2.21 to 3.36 log CFU/cm2. In study 1, the APC for breasts rinsed with distilled white vinegar (3.22 log CFU/cm2) was lower than for those rinsed with all other solutions except cranberry juice cocktail (3.86 log CFU/cm2). The TCC for breasts rinsed with distilled white vinegar (0.00 log CFU/cm2) and cranberry juice cocktail (0.20 log CFU/cm2) were lower than those for all other solutions except 10% NaCl (0.43 log CFU/cm2) and 10% NaHCO3 (0.48 log CFU/cm2). In study 2, APC values for breasts rinsed with red wine (5.29 log CFU/cm2) and white wine (5.32 log CFU/cm2) were lower than for breasts rinsed with the other three solutions. The TCC after rinsing with chicken broth (4.48 log CFU/cm2) was higher than for all other solutions except Italian dressing. Although distilled white vinegar was the most effective rinsing agent, all solutions produced lower counts after rinsing, indicating that consumers could use rinsing to remove microorganisms from chicken breast surfaces prior to cooking.

An equation for the prediction of human skin permeability of neutral molecules, ions and ionic species.

PubMed

Zhang, Keda; Abraham, Michael H; Liu, Xiangli

2017-04-15

Experimental values of permeability coefficients, as log K p , of chemical compounds across human skin were collected by carefully screening the literature, and adjusted to 37°C for the effect of temperature. The values of log K p for partially ionized acids and bases were separated into those for their neutral and ionic species, forming a total data set of 247 compounds and species (including 35 ionic species). The obtained log K p values have been regressed against Abraham solute descriptors to yield a correlation equation with R 2 =0.866 and SD=0.432 log units. The equation can provide valid predictions for log K p of neutral molecules, ions and ionic species, with predictive R 2 =0.858 and predictive SD=0.445 log units calculated by the leave-one-out statistics. The predicted log K p values for Na + and Et 4 N + are in good agreement with the observed values. We calculated the values of log K p of ketoprofen as a function of the pH of the donor solution, and found that log K p markedly varies only when ketoprofen is largely ionized. This explains why models that neglect ionization of permeants still yield reasonable statistical results. The effect of skin thickness on log K p was investigated by inclusion of two indicator variables, one for intermediate thickness skin and one for full thickness skin, into the above equation. The newly obtained equations were found to be statistically very close to the above equation. Therefore, the thickness of human skin used makes little difference to the experimental values of log K p . Copyright © 2017 Elsevier B.V. All rights reserved.

Endogenous Sex Steroid Hormones, Lipid Subfractions, and Ectopic Adiposity in Asian Indians.

PubMed

Kim, Catherine; Kong, Shengchun; Krauss, Ronald M; Stanczyk, Frank Z; Reddy, Srinivasa T; Needham, Belinda L; Kanaya, Alka M

2015-12-01

Estradiol, testosterone (T), and sex hormone binding globulin (SHBG) levels are associated with lipid subfractions in men and women. Our objective was to determine if associations are independent from adipose tissue area among Asian Indians. We used data from 42 women and 57 Asian Indian men who did not use exogenous steroids or lipid-lowering medications. Lipoprotein subfractions including low-density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol (VLDL), and intermediate density lipoprotein (IDL) were assessed by ion mobility spectrometry. Intra-abdominal adiposity was assessed by computed tomography. Multivariable regression models estimated the association between sex hormones with lipoprotein subfractions before and after adjustment for adiposity. Among women, lower logSHBG levels were associated with smaller logLDL particle size and higher logtriglycerides, logVLDL, and logIDL, although these associations were attenuated with adjustment for visceral adiposity in particular. Among women, lower logSHBG levels was significantly associated with lower logmedium LDL and logsmall LDL concentrations even after consideration of visceral and hepatic adiposity and insulin resistance as represented by the homeostasis model assessment of insulin resistance (HOMA-IR). Among men, lower logSHBG was also associated with smaller logLDL peak diameter size and higher logtriglycerides and logVLDL, even after adjustment for HOMA-IR and adiposity. Relationships between sex steroids and lipid subfractions were not significant among women. Among men, higher total testosterone was associated with higher logHDL and logLDL particle size, and lower logtriglycerides and logVLDL, but these associations were partially attenuated with adjustment for adiposity and HOMA-IR. Among Asian Indians, SHBG is associated with more favorable lipid subfraction concentrations, independent of hepatic and visceral fat.

Selective logging: does the imprint remain on tree structure and composition after 45 years?

PubMed

Osazuwa-Peters, Oyomoare L; Chapman, Colin A; Zanne, Amy E

2015-01-01

Selective logging of tropical forests is increasing in extent and intensity. The duration over which impacts of selective logging persist, however, remains an unresolved question, particularly for African forests. Here, we investigate the extent to which a past selective logging event continues to leave its imprint on different components of an East African forest 45 years later. We inventoried 2358 stems ≥10 cm in diameter in 26 plots (200 m × 10 m) within a 5.2 ha area in Kibale National Park, Uganda, in logged and unlogged forest. In these surveys, we characterized the forest light environment, taxonomic composition, functional trait composition using three traits (wood density, maximum height and maximum diameter) and forest structure based on three measures (stem density, total basal area and total above-ground biomass). In comparison to unlogged forests, selectively logged forest plots in Kibale National Park on average had higher light levels, different structure characterized by lower stem density, lower total basal area and lower above-ground biomass, and a distinct taxonomic composition driven primarily by changes in the relative abundance of species. Conversely, selectively logged forest plots were like unlogged plots in functional composition, having similar community-weighted mean values for wood density, maximum height and maximum diameter. This similarity in functional composition irrespective of logging history may be due to functional recovery of logged forest or background changes in functional attributes of unlogged forest. Despite the passage of 45 years, the legacy of selective logging on the tree community in Kibale National Park is still evident, as indicated by distinct taxonomic and structural composition and reduced carbon storage in logged forest compared with unlogged forest. The effects of selective logging are exerted via influences on tree demography rather than functional trait composition.

Selective logging: does the imprint remain on tree structure and composition after 45 years?

PubMed Central

Osazuwa-Peters, Oyomoare L.; Chapman, Colin A.; Zanne, Amy E.

2015-01-01

Selective logging of tropical forests is increasing in extent and intensity. The duration over which impacts of selective logging persist, however, remains an unresolved question, particularly for African forests. Here, we investigate the extent to which a past selective logging event continues to leave its imprint on different components of an East African forest 45 years later. We inventoried 2358 stems ≥10 cm in diameter in 26 plots (200 m × 10 m) within a 5.2 ha area in Kibale National Park, Uganda, in logged and unlogged forest. In these surveys, we characterized the forest light environment, taxonomic composition, functional trait composition using three traits (wood density, maximum height and maximum diameter) and forest structure based on three measures (stem density, total basal area and total above-ground biomass). In comparison to unlogged forests, selectively logged forest plots in Kibale National Park on average had higher light levels, different structure characterized by lower stem density, lower total basal area and lower above-ground biomass, and a distinct taxonomic composition driven primarily by changes in the relative abundance of species. Conversely, selectively logged forest plots were like unlogged plots in functional composition, having similar community-weighted mean values for wood density, maximum height and maximum diameter. This similarity in functional composition irrespective of logging history may be due to functional recovery of logged forest or background changes in functional attributes of unlogged forest. Despite the passage of 45 years, the legacy of selective logging on the tree community in Kibale National Park is still evident, as indicated by distinct taxonomic and structural composition and reduced carbon storage in logged forest compared with unlogged forest. The effects of selective logging are exerted via influences on tree demography rather than functional trait composition. PMID:27293697

Downhole logs of natural gamma radiation and magnetic susceptibility and their use in interpreting lithostratigraphy in AND-1B, Antarctica

NASA Astrophysics Data System (ADS)

Williams, T.; Morin, R. H.; Jarrard, R. D.; Jackolski, C. L.; Henrys, S. A.; Niessen, F.; Magens, D.; Kuhn, G.; Monien, D.; Powell, R. D.

2010-12-01

The ANDRILL McMurdo Ice Shelf (MIS) project drilled 1285 metres of sediment representing the last 14 million years of glacial history. Downhole geophysical logs were acquired to a depth of 1018 metres, and are complementary to data acquired from the core itself. We describe here the natural gamma radiation (NGR) and magnetic susceptibility logs, and their application to understanding lithological and paleoenvironmental change at ANDRILL McMurdo Ice Shelf Hole AND-1B. Natural gamma radiation logs cover the whole interval from the sea floor to 1018 metres, and magnetic susceptibility and other logs covered the open-hole intervals between 692-1018 and 237-342 metres. NGR logs were stacked and corrected for signal attenuation through the drill pipe, and magnetic susceptibility logs were corrected for drift. In the upper part of AND-1B, clear alternations between low and high NGR values distinguish between diatomite (lacking minerals containing naturally radioactive K, U, and Th) and diamict (containing K-bearing clays, K-feldspar, and heavy minerals). In the lower open-hole logged section, NGR and magnetic susceptibility can also distinguish claystones (rich in K-bearing clay minerals, relatively low in magnetite) and diamicts (relatively high in magnetite), while sandstones generally have high resistivity log values at AND-1B. On the basis of these three downhole logs, three sets of facies can be predicted correctly for 74% of the 692-1018m interval. The logs were then used to predict facies for the 7% of this interval that was unrecovered by coring. Similarly, the NGR log provides the best information on the lithology of the poorly recovered top 25m of AND-1B. Given the understanding of the physical property characteristics of different facies, it is also possible to identify subtle changes in lithology from the physical properties, and help refine parts of the lithostratigraphy (for example, the varying terrigenous content of diatomites).

Fungi and wind strongly influence the temporal availability of logs in an old-growth spruce forest.

PubMed

Edman, Mattias; Jönsson, Mari; Jonsson, Bengt Gunnar

2007-03-01

Coarse woody debris (CWD) is a key habitat for many species in forest ecosystems. To ensure the long-term survival of such species, forest management regimes must include measures that promote dead wood dynamics similar to those of natural forests. Thus, information on CWD dynamics under natural conditions is required, including data pertaining to the underlying agents of disturbance. This study examines modes of mortality, decay rates, and temporal patterns in the availability of Picea abies logs in a Swedish old-growth forest affected by internal, small-scale disturbance. All 684 logs in a 6.6-ha plot were mapped and classified into one of six decay classes. Logs in the early stages of decay were examined for the presence of heart-rot fungi. Six years later all logs were re-inventoried, including newly formed logs. Matrix models based on the transition rates between decay classes showed that it took about 60 years for 90% of the logs to decay beyond class 6 (a deformed trunk with soft wood). Large logs (> 26 cm) decayed 40% more slowly than small logs (< 25 cm). The initial volume of logs was 37.6 m3/ha but increased to 44.8 m3/ha after six years. In addition, there was a large shift in the decay-class distribution. The volume of logs in early and late decay classes increased by 71% and 45%, respectively, while the volume of logs in the intermediate decay classes decreased by 32%. The fluctuations appear to result from pulses in mortality, driven by a combination of strong winds and the heart-rot fungus, Phellinus chrysoloma, which was present in more than 30% of all logs at an early stage of decay. These results show that large temporal fluctuations in dead wood also occur in the absence of large-scale disturbance, and that heart-rot fungi are important factors driving the overall dynamics of dead wood. Since many wood-inhabiting species are naturally rare and have very specific substrate demands, such temporal variability in dead wood availability may have effects on biodiversity and should be taken into account when designing small, protected forest areas.

Description of borehole geophysical and geologist logs, Berks Sand Pit Superfund Site, Longswamp Township, Berks County, Pennsylvania

USGS Publications Warehouse

Low, Dennis J.; Conger, Randall W.

2003-01-01

Between October 2002 and January 2003, geophysical logging was conducted in six boreholes at the Berks Sand Pit Superfund Site, Longswamp Township, Berks County, Pa., to determine (1) the waterproducing zones, water-receiving zones, zones of vertical borehole flow, orientation of fractures, and borehole and casing depth; and (2) the hydraulic interconnection between the six boreholes and the site extraction well. The boreholes range in depth from 61 to 270 feet. Geophysical logging included collection of caliper, natural-gamma, single-point-resistance, fluid-temperature, fluid-flow, and acoustic-televiewer logs. Caliper and acoustic-televiewer logs were used to locate fractures, joints, and weathered zones. Inflections on fluid-temperature and single-point-resistance logs indicated possible water-bearing fractures, and flowmeter measurements verified these locations. Single-point-resistance, natural-gamma, and geologist logs provided information on stratigraphy. Flowmeter measurements were conducted while the site extraction well was pumping and when it was inactive to determine the hydraulic connections between the extraction well and the boreholes.Borehole geophysical logging and heatpulse flowmetering indicate active flow in the boreholes. Two of the boreholes are in ground-water discharge areas, two boreholes are in ground-water recharge areas, and one borehole is in an intermediate regime. Flow was not determined in one borehole. Heatpulse flowmetering, in conjunction with the geologist logs, indicates highly weathered zones in the granitic gneiss can be permeable and effective transmitters of water, confirming the presence of a two-tiered ground-water-flow system. The effort to determine a hydraulic connection between the site extraction well and six logged boreholes was not conclusive. Three boreholes showed decreases in depth to water after pumping of the site extraction well; in two boreholes, the depth to water increased. One borehole was cased its entire depth and was not revisited after it was logged by the caliper log. Substantial change in flow rates or direction of borehole flow was not observed in any of the three wells logged with the heatpulse flowmeter when the site extraction well was pumping and when it was inactive.

Selective logging: do rates of forest turnover in stems, species composition and functional traits decrease with time since disturbance? – A 45 year perspective

PubMed Central

Osazuwa-Peters, Oyomoare L.; Jiménez, Iván; Oberle, Brad; Chapman, Colin A.; Zanne, Amy E.

2015-01-01

Selective logging, the targeted harvesting of timber trees in a single cutting cycle, is globally rising in extent and intensity. Short-term impacts of selective logging on tropical forests have been widely investigated, but long-term effects on temporal dynamics of forest structure and composition are largely unknown. Understanding these long-term dynamics will help determine whether tropical forests are resilient to selective logging and inform choices between competing demands of anthropogenic use versus conservation of tropical forests. Forest dynamics can be studied within the framework of succession theory, which predicts that temporal turnover rates should decline with time since disturbance. Here, we investigated the temporal dynamics of a tropical forest in Kibale National Park, Uganda over 45 years following selective logging. We estimated turnover rates in stems, species composition, and functional traits (wood density and diameter at breast height), using observations from four censuses in 1989, 1999, 2006, and 2013, of stems ≥ 10 cm diameter within 17 unlogged and 9 logged 200 × 10 m vegetation plots. We used null models to account for interdependencies among turnover rates in stems, species composition, and functional traits. We tested predictions that turnover rates should be higher and decrease with increasing time since the selective logging event in logged forest, but should be less temporally variable in unlogged forest. Overall, we found higher turnover rates in logged forest for all three attributes, but turnover rates did not decline through time in logged forest and was not less temporally variable in unlogged forest. These results indicate that successional models that assume recovery to pre-disturbance conditions are inadequate for predicting the effects of selective logging on the dynamics of the tropical forest in Kibale. Selective logging resulted in persistently higher turnover rates, which may compromise the carbon storage capacity of Kibale’s forest. Selective logging effects may also interact with effects from other global trends, potentially causing major long-term shifts in the dynamics of tropical forests. Similar studies in tropical forests elsewhere will help determine the generality of these conclusions. Ultimately, the view that selective logging is a benign approach to the management of tropical forests should be reconsidered in the light of studies of the effects of this practice on long-term forest dynamics. PMID:26339115

Selective logging: do rates of forest turnover in stems, species composition and functional traits decrease with time since disturbance? - A 45 year perspective.

PubMed

Osazuwa-Peters, Oyomoare L; Jiménez, Iván; Oberle, Brad; Chapman, Colin A; Zanne, Amy E

2015-12-01

Selective logging, the targeted harvesting of timber trees in a single cutting cycle, is globally rising in extent and intensity. Short-term impacts of selective logging on tropical forests have been widely investigated, but long-term effects on temporal dynamics of forest structure and composition are largely unknown. Understanding these long-term dynamics will help determine whether tropical forests are resilient to selective logging and inform choices between competing demands of anthropogenic use versus conservation of tropical forests. Forest dynamics can be studied within the framework of succession theory, which predicts that temporal turnover rates should decline with time since disturbance. Here, we investigated the temporal dynamics of a tropical forest in Kibale National Park, Uganda over 45 years following selective logging. We estimated turnover rates in stems, species composition, and functional traits (wood density and diameter at breast height), using observations from four censuses in 1989, 1999, 2006, and 2013, of stems ≥ 10 cm diameter within 17 unlogged and 9 logged 200 × 10 m vegetation plots. We used null models to account for interdependencies among turnover rates in stems, species composition, and functional traits. We tested predictions that turnover rates should be higher and decrease with increasing time since the selective logging event in logged forest, but should be less temporally variable in unlogged forest. Overall, we found higher turnover rates in logged forest for all three attributes, but turnover rates did not decline through time in logged forest and was not less temporally variable in unlogged forest. These results indicate that successional models that assume recovery to pre-disturbance conditions are inadequate for predicting the effects of selective logging on the dynamics of the tropical forest in Kibale. Selective logging resulted in persistently higher turnover rates, which may compromise the carbon storage capacity of Kibale's forest. Selective logging effects may also interact with effects from other global trends, potentially causing major long-term shifts in the dynamics of tropical forests. Similar studies in tropical forests elsewhere will help determine the generality of these conclusions. Ultimately, the view that selective logging is a benign approach to the management of tropical forests should be reconsidered in the light of studies of the effects of this practice on long-term forest dynamics.

TH-AB-201-12: Using Machine Log-Files for Treatment Planning and Delivery QA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stanhope, C; Liang, J; Drake, D

2016-06-15

Purpose: To determine the segment reduction and dose resolution necessary for machine log-files to effectively replace current phantom-based patient-specific quality assurance, while minimizing computational cost. Methods: Elekta’s Log File Convertor R3.2 records linac delivery parameters (dose rate, gantry angle, leaf position) every 40ms. Five VMAT plans [4 H&N, 1 Pulsed Brain] comprised of 2 arcs each were delivered on the ArcCHECK phantom. Log-files were reconstructed in Pinnacle on the phantom geometry using 1/2/3/4° control point spacing and 2/3/4mm dose grid resolution. Reconstruction effectiveness was quantified by comparing 2%/2mm gamma passing rates of the original and log-file plans. Modulation complexity scoresmore » (MCS) were calculated for each beam to correlate reconstruction accuracy and beam modulation. Percent error in absolute dose for each plan-pair combination (log-file vs. ArcCHECK, original vs. ArcCHECK, log-file vs. original) was calculated for each arc and every diode greater than 10% of the maximum measured dose (per beam). Comparing standard deviations of the three plan-pair distributions, relative noise of the ArcCHECK and log-file systems was elucidated. Results: The original plans exhibit a mean passing rate of 95.1±1.3%. The eight more modulated H&N arcs [MCS=0.088±0.014] and two less modulated brain arcs [MCS=0.291±0.004] yielded log-file pass rates most similar to the original plan when using 1°/2mm [0.05%±1.3% lower] and 2°/3mm [0.35±0.64% higher] log-file reconstructions respectively. Log-file and original plans displayed percent diode dose errors 4.29±6.27% and 3.61±6.57% higher than measurement. Excluding the phantom eliminates diode miscalibration and setup errors; log-file dose errors were 0.72±3.06% higher than the original plans – significantly less noisy. Conclusion: For log-file reconstructed VMAT arcs, 1° control point spacing and 2mm dose resolution is recommended, however, less modulated arcs may allow less stringent reconstructions. Following the aforementioned reconstruction recommendations, the log-file technique is capable of detecting delivery errors with equivalent accuracy and less noise than ArcCHECK QA. I am funded by an Elekta Research Grant.« less

Evaluation of the effects of ultraviolet light on bacterial contaminants inoculated into whole milk and colostrum, and on colostrum immunoglobulin G

PubMed Central

Pereira, R. V.; Bicalho, M. L.; Machado, V. S.; Lima, S.; Teixeira, A. G.; Warnick, L. D.; Bicalho, R. C.

2015-01-01

Raw milk and colostrum can harbor dangerous micro-organisms that can pose serious health risks for animals and humans. According to the USDA, more than 58% of calves in the United States are fed unpasteurized milk. The aim of this study was to evaluate the effect of UV light on reduction of bacteria in milk and colostrum, and on colostrum IgG. A pilot-scale UV light continuous (UVC) flow-through unit (45 J/cm2) was used to treat milk and colostrum. Colostrum and sterile whole milk were inoculated with Listeria innocua, Mycobacterium smegmatis, Salmonella serovar Typhimurium, Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae, and Acinetobacter baumannii before being treated with UVC. During UVC treatment, samples were collected at 5 time points and bacteria were enumerated using selective media. The effect of UVC on IgG was evaluated using raw colostrum from a nearby dairy farm without the addition of bacteria. For each colostrum batch, samples were collected at several different time points and IgG was measured using ELISA. The UVC treatment of milk resulted in a significant final count (log cfu/mL) reduction of Listeria monocytogenes (3.2 ± 0.3 log cfu/mL reduction), Salmonella spp. (3.7 ± 0.2 log cfu/mL reduction), Escherichia coli (2.8 ± 0.2 log cfu/mL reduction), Staph. aureus (3.4 ± 0.3 log cfu/mL reduction), Streptococcus spp. (3.4 ± 0.4 log cfu/mL reduction), and A. baumannii (2.8 ± 0.2 log cfu/mL reduction). The UVC treatment of milk did not result in a significant final count (log cfu/mL) reduction for M. smegmatis (1.8 ± 0.5 log cfu/mL reduction). The UVC treatment of colostrum was significantly associated with a final reduction of bacterial count (log cfu/mL) of Listeria spp. (1.4 ± 0.3 log cfu/mL reduction), Salmonella spp. (1.0 ± 0.2 log cfu/mL reduction), and Acinetobacter spp. (1.1 ± 0.3 log cfu/mL reduction), but not of E. coli (0.5 ± 0.3 log cfu/mL reduction), Strep. agalactiae (0.8 ± 0.2 log cfu/mL reduction), and Staph. aureus (0.4 ± 0.2 log cfu/mL reduction). The UVC treatment of colostrum significantly decreased the IgG concentration, with an observed final mean IgG reduction of approximately 50%. Development of new methods to reduce bacterial contaminants in colostrum must take into consideration the barriers imposed by its opacity and organic components, and account for the incidental damage to IgG caused by manipulating colostrum. PMID:24582452

Prediction of gas/particle partitioning of polybrominated diphenyl ethers (PBDEs) in global air: A theoretical study

NASA Astrophysics Data System (ADS)

Li, Y.-F.; Ma, W.-L.; Yang, M.

2015-02-01

Gas/particle (G/P) partitioning of semi-volatile organic compounds (SVOCs) is an important process that primarily governs their atmospheric fate, long-range atmospheric transport, and their routes of entering the human body. All previous studies on this issue are hypothetically based on equilibrium conditions, the results of which do not predict results from monitoring studies well in most cases. In this study, a steady-state model instead of an equilibrium-state model for the investigation of the G/P partitioning behavior of polybrominated diphenyl ethers (PBDEs) was established, and an equation for calculating the partition coefficients under steady state (KPS) of PBDEs (log KPS = log KPE + logα) was developed in which an equilibrium term (log KPE = log KOA + logfOM -11.91 where fOM is organic matter content of the particles) and a non-equilibrium term (log α, caused by dry and wet depositions of particles), both being functions of log KOA (octanol-air partition coefficient), are included. It was found that the equilibrium is a special case of steady state when the non-equilibrium term equals zero. A criterion to classify the equilibrium and non-equilibrium status of PBDEs was also established using two threshold values of log KOA, log KOA1, and log KOA2, which divide the range of log KOA into three domains: equilibrium, non-equilibrium, and maximum partition domain. Accordingly, two threshold values of temperature t, tTH1 when log KOA = log KOA1 and tTH2 when log KOA = log KOA2, were identified, which divide the range of temperature also into the same three domains for each PBDE congener. We predicted the existence of the maximum partition domain (the values of log KPS reach a maximum constant of -1.53) that every PBDE congener can reach when log KOA ≥ log KOA2, or t ≤ tTH2. The novel equation developed in this study was applied to predict the G/P partition coefficients of PBDEs for our Chinese persistent organic pollutants (POPs) Soil and Air Monitoring Program, Phase 2 (China-SAMP-II) program and other monitoring programs worldwide, including in Asia, Europe, North America, and the Arctic, and the results matched well with all the monitoring data, except those obtained at e-waste sites due to the unpredictable PBDE emissions at these sites. This study provided evidence that the newly developed steady-state-based equation is superior to the equilibrium-state-based equation that has been used in describing the G/P partitioning behavior over decades. We suggest that the investigation on G/P partitioning behavior for PBDEs should be based onsteady-state, not equilibrium state, and equilibrium is just a special case of steady-state when non-equilibrium factors can be ignored. We also believe that our new equation provides a useful tool for environmental scientists in both monitoring and modeling research on G/P partitioning of PBDEs and can be extended to predict G/P partitioning behavior for other SVOCs as well.

31 CFR 593.510 - Transactions related to the importation of any round log or timber product originating in Liberia...

Code of Federal Regulations, 2010 CFR

2010-07-01

... importation of any round log or timber product originating in Liberia authorized. 593.510 Section 593.510... importation of any round log or timber product originating in Liberia authorized. Except as otherwise... into the United States of any round log or timber product originating in Liberia are authorized. ...

Review of the logging residue problem and its reduction through marketing practices.

Treesearch

Thomas C. Adams; Richard C. Smith

1976-01-01

This study notes the increasing concern over logging residue in forest land management and describes the various administrative and technological means for accomplishing reductions of logging residue. Alternative sales arrangements can include such things as reduction of stumpage charges for low quality logs or required yarding of unutilized material to the landing or...

Locating knots by industrial tomography- A feasibility study

Treesearch

Fred W. Taylor; Francis G. Wagner; Charles W. McMillin; Ira L. Morgan; Forrest F. Hopkins

1984-01-01

Industrial photon tomography was used to scan four southern pine logs and one red oak log. The logs were scanned at 16 cross-sectional slice planes located 1 centimeter apart along their longitudinal axes. Tomographic reconstructions were made from the scan data collected at these slice planes, and a cursory image analysis technique was developed to locate the log...

A three-dimensional optimal sawing system for small sawmills in central Appalachia

Treesearch

Wenshu Lin; Jingxin Wang; R. Edward. Thomas

2011-01-01

A three-dimensional (3D) log sawing optimization system was developed to perform 3D log generation, opening face determination, sawing simulation, and lumber grading. Superficial characteristics of logs such as length, large-end and small-end diameters, and external defects were collected from local sawmills. Internal log defect positions and shapes were predicted...

76 FR 11680 - Service Contracts and Non-Vessel-Operating Service Arrangements; Transmission of Approved Log-In...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... Contracts and Non-Vessel-Operating Service Arrangements; Transmission of Approved Log-In ID and Passwords... advise applicants for log-in IDs and passwords. DATES: The Final Rule is effective March 3, 2011. FOR... the U.S. Mail to transmit approved log-on IDs and password to registrants in the Commission's...

12 CFR 27.4 - Inquiry/Application Log.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Inquiry/Application Log. 27.4 Section 27.4... SYSTEM § 27.4 Inquiry/Application Log. (a) The Comptroller, among other things, may require a bank to maintain a Fair Housing Inquiry/Application Log (“Log”), based upon, but not limited to, one or more of the...

12 CFR 27.4 - Inquiry/Application Log.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inquiry/Application Log. 27.4 Section 27.4... SYSTEM § 27.4 Inquiry/Application Log. (a) The Comptroller, among other things, may require a bank to maintain a Fair Housing Inquiry/Application Log (“Log”), based upon, but not limited to, one or more of the...

Learning Logs in the Science Classroom: The Literacy Advantage

ERIC Educational Resources Information Center

Steenson, Cheryl

2006-01-01

In this article, the author discusses one of the most functional forms of writing to learn, the two-column learning logs. Two-column learning logs are based on the premise that collecting information and processing information are two very different aspects of learning. Two-column logs allow students to connect the facts and theories of science to…

Logging damage in thinned, young-growth true fir stands in California and recommendations for prevention.

Treesearch

Paul E. Aho; Gary Fiddler; Mike. Srago

1983-01-01

Logging-damage surveys and tree-dissection studies were made in commercially thinned, naturally established young-growth true fir stands in the Lassen National Forest in northern California. Significant damage occurred to residual trees in stands logged by conventional methods. Logging damage was substantially lower in stands thinned using techniques designed to reduce...

Economic incentives exist to support measures to reduce illegal logging

Treesearch

J.A. Turner; J. Buongiorno; A. Katz; S. Zhu; R. Li

2008-01-01

Three studies of the global economic implications of eliminating illegal logging are summarized. Processors of illegally sourced wood would lose from the elimination of illegal logging through high prices for logs and decreased production of wood products. Associated with these changes could be losses in employment and income. Beyond these losses to the processing...

Linking log quality with product performance

Treesearch

D. W. Green; Robert Ross

1997-01-01

In the United States, log grading procedures use visual assessment of defects, in relation to the log scaling diameter, to estimate the yield of lumber that maybe expected from the log. This procedure was satisfactory when structural grades were based only on defect size and location. In recent years, however, structural products have increasingly been graded using a...

ALOG user's manual: A Guide to using the spreadsheet-based artificial log generator

Treesearch

Matthew F. Winn; Philip A. Araman; Randolph H. Wynne

2012-01-01

Computer programs that simulate log sawing can be valuable training tools for sawyers, as well as a means oftesting different sawing patterns. Most available simulation programs rely on diagrammed-log databases, which canbe very costly and time consuming to develop. Artificial Log Generator (ALOG) is a user-friendly Microsoft® Excel®...

Montana Logging Utilization, 2002

Treesearch

Todd A. Morgan; Timothy P. Spoelma; Charles E. Keegan; Alfred L. Chase; Michael T. Thompson

2005-01-01

A study of logging utilization in Montana during 2002 provided logging and product utilization data for sawlog and veneer log harvests in Montana. Results of the study indicate a shift toward greater utilization of smaller diameter material, as 78 percent of the harvested volume in Montana during 2002 came from trees less than 17 inches diameter at breast height. The...

Relationships between log N-log S and celestial distribution of gamma-ray bursts

NASA Technical Reports Server (NTRS)

Nishimura, J.; Yamagami, T.

1985-01-01

The apparent conflict between log N-log S curve and isotropic celestial distribution of the gamma ray bursts is discussed. A possible selection effect due to the time profile of each burst is examined. It is shown that the contradiction is due to this selection effect of the gamma ray bursts.

Selective logging and its relation to deforestation

Treesearch

Gregory P. Asner; Michael Keller; Marco Lentini; Frank Merry; Souza Jr. Carlos

2009-01-01

Selective logging is a major contributor to the social, economic, and ecological dynamics of Brazilian Amazonia. Logging activities have expanded from low-volume floodplain harvests in past centuries to high-volume operations today that take about 25 million m3 of wood from the forest each year. The most common high-impact conventional and often illegal logging...

Microbial and chemical properties of log ponds along the Oregon Coast.

Treesearch

Iwan Ho; Ching Yan Li

1987-01-01

The microbial and chemical properties of log ponds along the Oregon coast were investigated. The log ponds were highly eutrophic, containing high concentrations of ammonium and nitrate nitrogen, phosphate, and organic compounds. Because of large microbial populations, the biochemical oxygen demand was high and dissolved oxygen was low. Bacterial species in log ponds...

Incidence of Russian log export tax: A vertical log-lumber model

Treesearch

Ying Lin; Daowei Zhang

2017-01-01

In 2007, Russia imposed an ad valorem tax on its log exports that lasted until 2012. In this paper, weuse a Muth-type equilibrium displacement model to investigate the market and welfare impacts of this tax, utilizing a vertical linkage between log and lumber markets and considering factor substitution. Our theoretical analysis indicates...

Development of regional stump-to-mill logging cost estimators

Treesearch

Chris B. LeDoux; John E. Baumgras

1989-01-01

Planning logging operations requires estimating the logging costs for the sale or tract being harvested. Decisions need to be made on equipment selection and its application to terrain. In this paper a methodology is described that has been developed and implemented to solve the problem of accurately estimating logging costs by region. The methodology blends field time...

Utilization and cost of log production from animal loging operations

Treesearch

Suraj P. Shrestha; Bobby L. Lanford; Robert B. Rummer; Mark Dubois

2006-01-01

Forest harvesting with animals is a labor-intensive operation. It is expensive to use machines on smaller woodlots, which require frequent moves if mechanically logged. So, small logging systems using animals may be more cost effective. In this study, work sampling was used for five animal logging operations in Alabama to measure productive and non-productive time...

Geophysical log analysis of selected test and residential wells at the Shenandoah Road National Superfund Site, East Fishkill, Dutchess County, New York

USGS Publications Warehouse

Reynolds, Richard J.; Anderson, J. Alton; Williams, John H.

2015-01-01

The geophysical logs and their analyses are available for display and download from the U.S. Geological Survey, New York Water Science Center, online geophysical log archive (http://ny.water.usgs.gov/maps/geologs/) in LAS (Log ASCII Standard), PDF, and WellCad formats.

31 CFR 593.205 - Prohibition on the importation of any round log or timber product originating in Liberia.

Code of Federal Regulations, 2012 CFR

2012-07-01

... round log or timber product originating in Liberia. 593.205 Section 593.205 Money and Finance: Treasury... on the importation of any round log or timber product originating in Liberia. Except as otherwise... section, the importation into the United States, directly or indirectly, of any round log or timber...

31 CFR 593.205 - Prohibition on the importation of any round log or timber product originating in Liberia.

Code of Federal Regulations, 2013 CFR

2013-07-01

... round log or timber product originating in Liberia. 593.205 Section 593.205 Money and Finance: Treasury... on the importation of any round log or timber product originating in Liberia. Except as otherwise... section, the importation into the United States, directly or indirectly, of any round log or timber...

31 CFR 593.205 - Prohibition on the importation of any round log or timber product originating in Liberia.

Code of Federal Regulations, 2014 CFR

2014-07-01

... round log or timber product originating in Liberia. 593.205 Section 593.205 Money and Finance: Treasury... on the importation of any round log or timber product originating in Liberia. Except as otherwise... section, the importation into the United States, directly or indirectly, of any round log or timber...

31 CFR 593.205 - Prohibition on the importation of any round log or timber product originating in Liberia.

Code of Federal Regulations, 2011 CFR

2011-07-01

... round log or timber product originating in Liberia. 593.205 Section 593.205 Money and Finance: Treasury... on the importation of any round log or timber product originating in Liberia. Except as otherwise... section, the importation into the United States, directly or indirectly, of any round log or timber...

31 CFR 593.510 - Transactions related to the importation of any round log or timber product originating in Liberia...

Code of Federal Regulations, 2012 CFR

2012-07-01

... importation of any round log or timber product originating in Liberia authorized. 593.510 Section 593.510... importation of any round log or timber product originating in Liberia authorized. Except as otherwise... into the United States of any round log or timber product originating in Liberia are authorized. ...

76 FR 71835 - Energy Conservation Program: Energy Conservation Standards for Direct Heating Equipment

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... Log Sets b. Vented Hearth Products C. National Energy Savings D. Other Comments 1. Test Procedures 2... address vented gas log sets. DOE clarified its position on vented gas log sets in a document published on... vented gas log sets are included in the definition of ``vented hearth heater''; DOE has reached this...

Key Indicators of Successful Logging Jobs in the Northeast

Treesearch

Owen W. Herrick

1976-01-01

Uncertainty and inadequate information for prediction hinder attempts to judge the chances for success on logging jobs. In this study, variation in the success of commercial logging jobs in the Northeast was examined to relate the kinds of conditions present to the chances of logging being most successful under those conditions. Respondents rated half of the sample...

Tangential scanning of hardwood logs: developing an industrial computer tomography scanner

Treesearch

Nand K. Gupta; Daniel L. Schmoldt; Bruce Isaacson

1999-01-01

It is generally believed that noninvasive scanning of hardwood logs such as computer tomography (CT) scanning prior to initial breakdown will greatly improve the processing of logs into lumber. This belief, however, has not translated into rapid development and widespread installation of industrial CT scanners for log processing. The roadblock has been more operational...

33 CFR 207.330 - Mississippi River between Winnibigoshish and Pokegama dams, Leech River between outlet of Leech...

Code of Federal Regulations, 2010 CFR

2010-07-01

... reservoir; logging. 207.330 Section 207.330 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT... reservoir; logging. (a) Parties engaged in the transportation of loose logs, timbers, and rafts of logs, poles, posts, ties, or pulpwood, on the waters described in this section, shall conduct their operations...

33 CFR 207.330 - Mississippi River between Winnibigoshish and Pokegama dams, Leech River between outlet of Leech...

Code of Federal Regulations, 2011 CFR

2011-07-01

... reservoir; logging. 207.330 Section 207.330 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT... reservoir; logging. (a) Parties engaged in the transportation of loose logs, timbers, and rafts of logs, poles, posts, ties, or pulpwood, on the waters described in this section, shall conduct their operations...

Potential Pacific Rim demand for construction-grade softwood logs.

Treesearch

Donald F. Flora; Richard R. Vlosky

1986-01-01

Markets for small lower grade ("construction-grade"), softwood logs are projected to expand steadily through 1995. Log supplies will lag slightly behind demand until 1990, generating about a 10-percent increase in prices. Prices are expected to be level thereafter. United States exports of construction-grade logs are projected to increase 35 percent by 1990...

Interactive machine learning for postprocessing CT images of hardwood logs

Treesearch

Erol Sarigul; A. Lynn Abbott; Daniel L. Schmoldt

2003-01-01

This paper concerns the nondestructive evaluation of hardwood logs through the analysis of computed tomography (CT) images. Several studies have shown that the commercial value of resulting boards can be increased substantially if log sawing strategies are chosen using prior knowledge of internal log defects. Although CT imaging offers a potential means of obtaining...

Relationship of log production in Oregon and Washington to economic conditions.

Treesearch

Brian R. Wall

1972-01-01

Increasing demand for timber has put upward pressure on log production levels in Oregon and Washington. Fluctuations in log production result primarily from changes in national demand for wood products. The log production cycle with respect to business conditions has become countercyclical since World War II. During the 1949-69 period, annual changes in housing starts...

A survey of animal-powered logging in Alabama

Treesearch

Christopher W. Toms; Mark R. Dubois; John C. Bliss; John H. Wilhoit; Robert B. Rummer

2001-01-01

In a state with a very large, highly mechanized timber harvesting industry, animal-powered logging still occupies a niche in Alabama as a small-scale harvesting alternative. This article summarizes the results from a study that examined the extent of animal logging in Alabama. We investigated this topic by asking who is logging with animals, where are they working,...

Sediment transport and soil disturbance after postfire logging.

Treesearch

James D. McIver

2003-01-01

Recently there has been considerable debate on the practice of postfire logging, in which burned forests are entered soon after fire to recover commercially valuable trees. Proponents of the practice argue that postfire logging is part of a 'restoration package' that can be used to control erosion (e.g., contour logging) and can help to mitigate costs of...

Challenges in converting among log scaling methods.

Treesearch

Henry Spelter

2003-01-01

The traditional method of measuring log volume in North America is the board foot log scale, which uses simple assumptions about how much of a log's volume is recoverable. This underestimates the true recovery potential and leads to difficulties in comparing volumes measured with the traditional board foot system and those measured with the cubic scaling systems...

Selective logging in the Brazilian Amazon.

PubMed

Asner, Gregory P; Knapp, David E; Broadbent, Eben N; Oliveira, Paulo J C; Keller, Michael; Silva, Jose N

2005-10-21

Amazon deforestation has been measured by remote sensing for three decades. In comparison, selective logging has been mostly invisible to satellites. We developed a large-scale, high-resolution, automated remote-sensing analysis of selective logging in the top five timber-producing states of the Brazilian Amazon. Logged areas ranged from 12,075 to 19,823 square kilometers per year (+/-14%) between 1999 and 2002, equivalent to 60 to 123% of previously reported deforestation area. Up to 1200 square kilometers per year of logging were observed on conservation lands. Each year, 27 million to 50 million cubic meters of wood were extracted, and a gross flux of approximately 0.1 billion metric tons of carbon was destined for release to the atmosphere by logging.

The three-dimensional structure of "Lonely Guy" from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins.

PubMed

Dzurová, Lenka; Forneris, Federico; Savino, Simone; Galuszka, Petr; Vrabka, Josef; Frébort, Ivo

2015-08-01

The recently discovered cytokinin (CK)-specific phosphoribohydrolase "Lonely Guy" (LOG) is a key enzyme of CK biosynthesis, converting inactive CK nucleotides into biologically active free bases. We have determined the crystal structures of LOG from Claviceps purpurea (cpLOG) and its complex with the enzymatic product phosphoribose. The structures reveal a dimeric arrangement of Rossmann folds, with the ligands bound to large pockets at the interface between cpLOG monomers. Structural comparisons highlight the homology of cpLOG to putative lysine decarboxylases. Extended sequence analysis enabled identification of a distinguishing LOG sequence signature. Taken together, our data suggest phosphoribohydrolase activity for several proteins of unknown function. © 2015 Wiley Periodicals, Inc.

High-dose cytarabine in induction treatment improves the outcome of adult patients younger than age 46 years with acute myeloid leukemia: results of the EORTC-GIMEMA AML-12 trial.

PubMed

Willemze, Roelof; Suciu, Stefan; Meloni, Giovanna; Labar, Boris; Marie, Jean-Pierre; Halkes, Constantijn J M; Muus, Petra; Mistrik, Martin; Amadori, Sergio; Specchia, Giorgina; Fabbiano, Francesco; Nobile, Francesco; Sborgia, Marco; Camera, Andrea; Selleslag, Dominik L D; Lefrère, Francois; Magro, Domenico; Sica, Simona; Cantore, Nicola; Beksac, Meral; Berneman, Zwi; Thomas, Xavier; Melillo, Lorella; Guimaraes, Jose E; Leoni, Pietro; Luppi, Mario; Mitra, Maria E; Bron, Dominique; Fillet, Georges; Marijt, Erik W A; Venditti, Adriano; Hagemeijer, Anne; Mancini, Marco; Jansen, Joop; Cilloni, Daniela; Meert, Liv; Fazi, Paola; Vignetti, Marco; Trisolini, Silvia M; Mandelli, Franco; de Witte, Theo

2014-01-20

Cytarabine plays a pivotal role in the treatment of patients with acute myeloid leukemia (AML). Most centers use 7 to 10 days of cytarabine at a daily dose of 100 to 200 mg/m(2) for remission induction. Consensus has not been reached on the benefit of higher dosages of cytarabine. The European Organisation for Research and Treatment of Cancer (EORTC) and Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Leukemia Groups conducted a randomized trial (AML-12; Combination Chemotherapy, Stem Cell Transplant and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia) in 1,942 newly diagnosed patients with AML, age 15 to 60 years, comparing remission induction treatment containing daunorubicin, etoposide, and either standard-dose (SD) cytarabine (100 mg/m(2) per day by continuous infusion for 10 days) or high-dose (HD) cytarabine (3,000 mg/m(2) every 12 hours by 3-hour infusion on days 1, 3, 5, and 7). Patients in complete remission (CR) received a single consolidation cycle containing daunorubicin and intermediate-dose cytarabine (500 mg/m(2) every 12 hours for 6 days). Subsequently, a stem-cell transplantation was planned. The primary end point was survival. At a median follow-up of 6 years, overall survival was 38.7% for patients randomly assigned to SD cytarabine and 42.5% for those randomly assigned to HD cytarabine (log-rank test P = .06; multivariable analysis P = .009). For patients younger than age 46 years, survival was 43.3% and 51.9%, respectively (P = .009; multivariable analysis P = .003), and for patients age 46 to 60 years, survival was 33.9% and 32.9%, respectively (P = .91). CR rates were 72.0% and 78.7%, respectively (P < .001) and were 75.6% and 82.4% for patients younger than age 46 years (P = .01) and 68.3% and 74.8% for patients age 46 years and older (P = .03). Patients of all ages with very-bad-risk cytogenetic abnormalities and/or FLT3-ITD (internal tandem duplication) mutation, or with secondary AML benefitted from HD cytarabine. HD cytarabine produces higher remission and survival rates than SD cytarabine, especially in patients younger than age 46 years.

Analyzing Decision Logs to Understand Decision Making in Serious Crime Investigations.

PubMed

Dando, Coral J; Ormerod, Thomas C

2017-12-01

Objective To study decision making by detectives when investigating serious crime through the examination of decision logs to explore hypothesis generation and evidence selection. Background Decision logs are used to record and justify decisions made during serious crime investigations. The complexity of investigative decision making is well documented, as are the errors associated with miscarriages of justice and inquests. The use of decision logs has not been the subject of an empirical investigation, yet they offer an important window into the nature of investigative decision making in dynamic, time-critical environments. Method A sample of decision logs from British police forces was analyzed qualitatively and quantitatively to explore hypothesis generation and evidence selection by police detectives. Results Analyses revealed diversity in documentation of decisions that did not correlate with case type and identified significant limitations of the decision log approach to supporting investigative decision making. Differences emerged between experienced and less experienced officers' decision log records in exploration of alternative hypotheses, generation of hypotheses, and sources of evidential inquiry opened over phase of investigation. Conclusion The practical use of decision logs is highly constrained by their format and context of use. Despite this, decision log records suggest that experienced detectives display strategic decision making to avoid confirmation and satisficing, which affect less experienced detectives. Application Potential applications of this research include both training in case documentation and the development of new decision log media that encourage detectives, irrespective of experience, to generate multiple hypotheses and optimize the timely selection of evidence to test them.

Parental perceptions of the learner driver log book system in two Australian states.

PubMed

Bates, Lyndel; Watson, Barry; King, Mark Johann

2014-01-01

Though many jurisdictions internationally now require learner drivers to complete a specified number of hours of supervised driving practice before being able to drive unaccompanied, very few require learner drivers to complete a log book to record this practice and then present it to the licensing authority. Learner drivers in most Australian jurisdictions must complete a log book that records their practice, thereby confirming to the licensing authority that they have met the mandated hours of practice requirement. These log books facilitate the management and enforcement of minimum supervised hours of driving requirements. Parents of learner drivers in 2 Australian states, Queensland and New South Wales, completed an online survey assessing a range of factors, including their perceptions of the accuracy of their child's learner log book and the effectiveness of the log book system. The study indicates that the large majority of parents believe that their child's learner log book is accurate. However, they generally report that the log book system is only moderately effective as a system to measure the number of hours of supervised practice a learner driver has completed. The results of this study suggest the presence of a paradox, with many parents possibly believing that others are not as diligent in the use of log books as they are or that the system is too open to misuse. Given that many parents report that their child's log book is accurate, this study has important implications for the development and ongoing monitoring of hours of practice requirements in graduated driver licensing systems.

Mapping soil particle-size fractions: A comparison of compositional kriging and log-ratio kriging

NASA Astrophysics Data System (ADS)

Wang, Zong; Shi, Wenjiao

2017-03-01

Soil particle-size fractions (psf) as basic physical variables need to be accurately predicted for regional hydrological, ecological, geological, agricultural and environmental studies frequently. Some methods had been proposed to interpolate the spatial distributions of soil psf, but the performance of compositional kriging and different log-ratio kriging methods is still unclear. Four log-ratio transformations, including additive log-ratio (alr), centered log-ratio (clr), isometric log-ratio (ilr), and symmetry log-ratio (slr), combined with ordinary kriging (log-ratio kriging: alr_OK, clr_OK, ilr_OK and slr_OK) were selected to be compared with compositional kriging (CK) for the spatial prediction of soil psf in Tianlaochi of Heihe River Basin, China. Root mean squared error (RMSE), Aitchison's distance (AD), standardized residual sum of squares (STRESS) and right ratio of the predicted soil texture types (RR) were chosen to evaluate the accuracy for different interpolators. The results showed that CK had a better accuracy than the four log-ratio kriging methods. The RMSE (sand, 9.27%; silt, 7.67%; clay, 4.17%), AD (0.45), STRESS (0.60) of CK were the lowest and the RR (58.65%) was the highest in the five interpolators. The clr_OK achieved relatively better performance than the other log-ratio kriging methods. In addition, CK presented reasonable and smooth transition on mapping soil psf according to the environmental factors. The study gives insights for mapping soil psf accurately by comparing different methods for compositional data interpolation. Further researches of methods combined with ancillary variables are needed to be implemented to improve the interpolation performance.

Micellar versus hydro-organic mobile phases for retention-hydrophobicity relationship studies with ionizable diuretics and an anionic surfactant.

PubMed

Ruiz-Angel, M J; Carda-Broch, S; García-Alvarez-Coque, M C; Berthod, A

2004-03-19

Logarithm of retention factors (log k) of a group of 14 ionizable diuretics were correlated with the molecular (log P o/w) and apparent (log P(app)) octanol-water partition coefficients. The compounds were chromatographed using aqueous-organic (reversed-phase liquid chromatography, RPLC) and micellar-organic mobile phases (micellar liquid chromatography, MLC) with the anionic surfactant sodium dodecyl sulfate (SDS), in the pH range 3-7, and a conventional octadecylsilane column. Acetonitrile was used as the organic modifier in both modes. The quality of the correlations obtained for log P(app) at varying ionization degree confirms that this correction is required in the aqueous-organic mixtures. The correlation is less improved with SDS micellar media because the acid-base equilibriums are shifted towards higher pH values for acidic compounds. In micellar chromatography, an electrostatic interaction with charged solutes is added to hydrophobic forces; consequently, different correlations should be established for neutral and acidic compounds, and for basic compounds. Correlations between log k and the isocratic descriptors log k(w), log k(wm) (extrapolated retention to pure water in the aqueous-organic and micellar-organic systems, respectively), and psi0 (extrapolated mobile phase composition giving a k = 1 retention factor or twice the dead time), and between these descriptors and log P(app) were also satisfactory, although poorer than those between log k and log P(app) due to the extrapolation. The study shows that, in the particular case of the ionizable diuretics studied, classical RPLC gives better results than MLC with SDS in the retention hydrophobicity correlations.

Surface Soil Changes Following Selective Logging in an Eastern Amazon Forest

NASA Technical Reports Server (NTRS)

Olander, Lydia P.; Bustamante, Mercedes M.; Asner, Gregory P.; Telles, Everaldo; Prado, Zayra; Camargo, Plinio B.

2005-01-01

In the Brazilian Amazon, selective logging is second only to forest conversion in its extent. Conversion to pasture or agriculture tends to reduce soil nutrients and site productivity over time unless fertilizers are added. Logging removes nutrients in bole wood, enough that repeated logging could deplete essential nutrients over time. After a single logging event, nutrient losses are likely to be too small to observe in the large soil nutrient pools, but disturbances associated with logging also alter soil properties. Selective logging, particularly reduced-impact logging, results in consistent patterns of disturbance that may be associated with particular changes in soil properties. Soil bulk density, pH, carbon (C), nitrogen (N), phosphorus (P), calcium (Ca), magnesium (Mg), potassium (K), iron (Fe), aluminum (Al), delta(sup 3)C, delta(sup 15)N, and P fractionations were measured on the soils of four different types of loggingrelated disturbances: roads, decks, skids, and treefall gaps. Litter biomass and percent bare ground were also determined in these areas. To evaluate the importance of fresh foliage inputs from downed tree crowns in treefall gaps, foliar nutrients for mature forest trees were also determined and compared to that of fresh litterfall. The immediate impacts of logging on soil properties and how these might link to the longer-term estimated nutrient losses and the observed changes in soils were studied.

Revisiting the "Fundamental Plane" of Black Hole Activity at Extremely Low Luminosities

NASA Astrophysics Data System (ADS)

Yuan, F.; Yu, Z.; Ho, L. C.

2010-10-01

We investigate the origin of the X-ray emission in low-luminosity AGNs (LLAGNs). Yuan & Cui (2005) predicted that the X-ray emission should originate from jets rather than from an advection-dominated accretion flow (ADAF) when the X-ray luminosity LX of the source is below a critical value of LX,crit ≍ 10-6 LEdd. This prediction implies that the X-ray spectrum in such sources should be fitted by jets rather than ADAFs. Furthermore, below LX,crit the correlation between radio (LR) and X-ray (LX) luminosities and the black hole mass (M)—the so-called fundamental plane of black hole activity—should deviate from the general correlation obtained by Merloni, Heinz & Di Matteo (2003) and become steeper. The Merloni et al. correlation is described by logLR = 0.6logLX + 0.78logM + 7.33, while the predicted correlation is logL_R = 1.23logLX + 0.25logM - 13.45. We collect data from the literature to check the validity of these two expectations. We find that among the 16 LLAGNs with good X-ray and radio spectra, 13 are consistent with the Yuan & Cui prediction. For the 22 LLAGNs with LX < LX,crit, the fundamental plane correlation is described by logLR = 1.22logLX + 0.23logM - 12.46, also in excellent agreement with the prediction.

Carbon Emission from Forest Fires on Scots Pine Logging Sites in the Angara Region of Central Siberia

NASA Astrophysics Data System (ADS)

Ivanova, G. A.; Conard, S. G.; McRae, D. J.; Kukavskaya, E. A.; Bogorodskaya, A. V.; Kovaleva, N. M.

2010-12-01

Wildfire and large-scale forest harvesting are the two major disturbances in the Russian boreal forests. Non-recovered logged sites total about a million hectares in Siberia. Logged sites are characterized by higher fire hazard than forest sites due to the presence of generally untreated logging slash (i.e., available fuel) which dries out much more rapidly compared to understory fuels. Moreover, most logging sites can be easily accessed by local population; this increases the risk for fire ignition. Fire impacts on the overstory trees, subcanopy woody layer, and ground vegetation biomass were estimated on 14 logged and unlogged comparison sites in the Lower Angara Region in 2009-2010 as part of the NASA-funded NEESPI project, The Influence of Changing Forestry Practices on the Effects of Wildfire and on Interactions Between Fire and Changing Climate in Central Siberia. Based on calculated fuel consumption, we estimated carbon emission from fires on both logged and unlogged burned sites. Carbon emission from fires on logged sites appeared to be twice that on unlogged sites. Soil respiration decreased on both site types after fires. This reduction may partially offset fire-produced carbon emissions. Carbon emissions from fire and post-fire ecosystem damage on logged sites are expected to increase under changing climate conditions and as a result of anticipated increases in future forest harvesting in Siberia.

QSPR study of polychlorinated diphenyl ethers by molecular electronegativity distance vector (MEDV-4).

PubMed

Sun, Lili; Zhou, Liping; Yu, Yu; Lan, Yukun; Li, Zhiliang

2007-01-01

Polychlorinated diphenyl ethers (PCDEs) have received more and more concerns as a group of ubiquitous potential persistent organic pollutants (POPs). By using molecular electronegativity distance vector (MEDV-4), multiple linear regression (MLR) models are developed for sub-cooled liquid vapor pressures (P(L)), n-octanol/water partition coefficients (K(OW)) and sub-cooled liquid water solubilities (S(W,L)) of 209 PCDEs and diphenyl ether. The correlation coefficients (R) and the leave-one-out cross-validation (LOO) correlation coefficients (R(CV)) of all the 6-descriptor models for logP(L), logK(OW) and logS(W,L) are more than 0.98. By using stepwise multiple regression (SMR), the descriptors are selected and the resulting models are 5-descriptor model for logP(L), 4-descriptor model for logK(OW), and 6-descriptor model for logS(W,L), respectively. All these models exhibit excellent estimate capabilities for internal sample set and good predictive capabilities for external samples set. The consistency between observed and estimated/predicted values for logP(L) is the best (R=0.996, R(CV)=0.996), followed by logK(OW) (R=0.992, R(CV)=0.992) and logS(W,L) (R=0.983, R(CV)=0.980). By using MEDV-4 descriptors, the QSPR models can be used for prediction and the model predictions can hence extend the current database of experimental values.

Green lumber grade yields from factory grade logs of three oak species

Treesearch

Daniel A. Yaussy

1986-01-01

Multivariate regression models were developed to predict green board foot yields for the seven common factory lumber grades processed from white, black, and chestnut oak factory grade logs. These models use the standard log measurements of grade, scaling diameter, log length, and proportion of scaling defect. Any combination of lumber grades (such as 1 Common and...

Estimating the carbon in coarse woody debris with perpendicular distance sampling. Chapter 6

Treesearch

Harry T. Valentine; Jeffrey H. Gove; Mark J. Ducey; Timothy G. Gregoire; Michael S. Williams

2008-01-01

Perpendicular distance sampling (PDS) is a design for sampling the population of pieces of coarse woody debris (logs) in a forested tract. In application, logs are selected at sample points with probability proportional to volume. Consequently, aggregate log volume per unit land area can be estimated from tallies of logs at sample points. In this chapter we provide...

Pacific Rim log trade: determinants and trends.

Treesearch

Donald F. Flora; Andrea L. Anderson; Wendy J. McGinnls

1991-01-01

Pacific Rim trade in softwood logs amounts to about $3 billion annually, of which the U.S. share is about $2 billion. Log exporting is a significant part of the forest economy in the Pacific Northwest. The 10 major Pacific Rim log-trading client and competitor countries differ widely in their roles in trade and in their policies affecting the industry.

Diameter effect on stress-wave evaluation of modulus of elasticity of logs

Treesearch

Xiping Wang; Robert J. Ross; Brian K. Brashaw; John Punches; John R. Erickson; John W. Forsman; Roy E. Pellerin

2004-01-01

Recent studies on nondestructive evaluation (NDE) of logs have shown that a longitudinal stress-wave method can be used to nondestructively evaluate the modulus of elasticity (MOE) of logs. A strong relationship has been found between stress-wave MOE and static MOE of logs, but a significant deviation was observed between stress-wave and static values. The objective of...

HW Buck for Windows: the optimal hardwood log bucking decision simulator with expanded capabilities

Treesearch

James B. Pickens; Scott Noble; Blair Orr; Philip A. Araman; John E. Baumgras; Al Steele

2006-01-01

It has long been recognized that inappropriate placement of crosscuts when manufacturing hardwood logs from harvested stems (log bucking) reduces the value of logs produced. Recent studies have estimated losses in the range from 28% to 38% in the lake states region. These estimates were developed by evaluating the bucking cuts chosen by harvesting crews and comparing...

78 FR 21396 - Notice of a Federal Advisory Committee Meeting: Manufactured Housing Consensus Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... specifying the permissible scope and conduct of monitoring; and Be organized and carry out its business in a...-12 III. Review Log of Proposal: Log 1 24 CFR 3285--Alternative Foundation System Testing. Log 80 24...-fhydelarge.html ; Video explaining ASTM D6007: http://www.ntainc.com/video-fhyde.html . Log 81 24 CFR 3280...

Diameter effect on stress-wave evaluation of modulus of elasticity of logs

Treesearch

Xiping Wang; Robert J. Ross; Brian K. Brashaw; John R. Erickson; John W. Forsman; Roy Pellerin

2003-01-01

Recent studies on nondestructive evaluation (NDE) of logs have shown that a longitudinal stress-wave method can be used to nondestructively evaluate the modulus of elasticity (MOE) of logs. A strong relationship has been found between stress-wave MOE and static MOE of logs, but a significant deviation was observed between stress-wave and static values. The objective of...

Estimating load weights with Huber's Cubic Volume formula: a field trial.

Treesearch

Dale R. Waddell

1989-01-01

Log weights were estimated from the product of Huber's cubic volume formula and green density. Tags showing estimated log weights were attached to logs in the field, and the weights were tallied into a single load weight as logs were assembled for aerial yarding. Accuracy of the estimated load weights was evaluated by comparing the predicted with the actual load...

ALOG: A spreadsheet-based program for generating artificial logs

Treesearch

Matthew F. Winn; Randolph H. Wynne; Philip A. Araman

2004-01-01

Log sawing simulation computer programs can be valuable tools for training sawyers as well as for testing different sawing patterns. Most available simulation programs rely on databases from which to draw logs and can be very costly and time-consuming to develop. ALOG (Artificial LOg Generator) is a Microsoft Excel®-based computer program that was developed to...

Overlapping bark beetle outbreaks, salvage logging and wildfire restructure a lodgepole pine ecosystem

Treesearch

Charles C. Rhoades; Kristen A. Pelz; Paula J. Fornwalt; Brett H. Wolk; Antony S. Cheng

2018-01-01

The 2010 Church’s Park Fire burned beetle-killed lodgepole pine stands in Colorado, including recently salvage-logged areas, creating a fortuitous opportunity to compare the effects of salvage logging, wildfire and the combination of logging followed by wildfire. Here, we examine tree regeneration, surface fuels, understory plants, inorganic soil nitrogen and water...

Limits on Log Cross-Product Ratios for Item Response Models. Research Report. ETS RR-06-10

ERIC Educational Resources Information Center

Haberman, Shelby J.; Holland, Paul W.; Sinharay, Sandip

2006-01-01

Bounds are established for log cross-product ratios (log odds ratios) involving pairs of items for item response models. First, expressions for bounds on log cross-product ratios are provided for unidimensional item response models in general. Then, explicit bounds are obtained for the Rasch model and the two-parameter logistic (2PL) model.…

Computer-Generated Optimum Hardwood Log Sawing Using Internal Defect Information

Treesearch

Luis G. Occeña; Daniel L. Schmoldt

1994-01-01

The planning of how the hardwood log can be sawn to improve recovery of high-value lumber has always been hampered by the limited information provided by external defects, and whatever internal defects are eventually revealed on the cut log faces by the sawing pattern. With expanded export and domestic markets, low-quality logs, increased competition from non-wood...

Intensive hardwood log bucker training using HW Buck dramatically improves value recovery

Treesearch

James B. Pickens; Aaron Everett; Scott Noble; John E. Baumgras; Philip A. Araman; Conrad Waniger; Al Steele

2006-01-01

It has long been recognized that inappropriate placement of crosscuts when manufacturing hardwood logs from harvested stems (log bucking) reduces the value of logs produced. Recent studies have estimated losses in the range from 28% to 38% in the lake states region. It has not, however, been clear how to correct the problem. Efforts to improve value recovery have...

Development of a 3D log sawing optimization system for small sawmills in central Appalachia, US

Treesearch

Wenshu Lin; Jingxin Wang; Edward Thomas

2011-01-01

A 3D log sawing optimization system was developed to perform log generation, opening face determination, sawing simulation, and lumber grading using 3D modeling techniques. Heuristic and dynamic programming algorithms were used to determine opening face and grade sawing optimization. Positions and shapes of internal log defects were predicted using a model developed by...

Tree damage from skyline logging in a western larch/Douglas-fir stand

Treesearch

Robert E. Benson; Michael J. Gonsior

1981-01-01

Damage to shelterwood leave trees and to understory trees in shelterwood and clearcut logging units logged with skyline yarders was measured, and related to stand conditions, harvesting specifications, and yarding system-terrain interactions. About 23 percent of the marked leave trees in the shelterwood units were killed in logging, and about 10 percent had moderate to...

Using low-grade hardwoods for CLT production: a yield analysis

Treesearch

R. Edward Thomas; Urs Buehlmann

2017-01-01

Low-grade hardwood logs are the by-product of logging operations and, more frequently today, urban tree removals. The market prices for these logs is low, as is the value recovered from their logs when producing traditional forest products such as pallet parts, railroad ties, landscaping mulch, or chips for pulp. However, the emergence of cross-laminated timber (CLT)...

Influence of forest and rangeland management on anadromous fish habitat in Western North America: water transportation and storage of logs.

Treesearch

J.R. Sedell; W.S. Duval

1985-01-01

Environmental effects of water transportation of logs in western North America include the historical driving of logs in rivers and streams, and the current dumping, sorting, transportation, and storage of logs in rivers and estuaries in British Columbia and southeastern Alaska. The historical discussion focuses on habitat losses and volumes of...

Dimension yields from short logs of low-quality hardwood trees.

Treesearch

Howard N. Rosen; Harold A. Stewart; David J. Polak

1980-01-01

Charts are presented for determining yields of 4/4 dimension cuttings from short hardwood logs of aspen, soft maple, black cherry, yellow-poplar, and black walnut for several cutting grades and bolt sizes. Cost comparisons of short log and standard grade mixes show sizes. Cost comparisons of short log and standard grade mixes show the estimated least expensive...

Overruns - Southern Pine Logs

Treesearch

Robert A. Campbell

1962-01-01

Overrun and underrun data were collected for the four major southern pine species during a series of grade yield studies in the late 1950's in Arkansas, Florida, Georgia, Mississippi, and South Carolina. Each of the 1,491 logs was carefully scaled by the Doyle, Scribner Decimal C, and International ¼-inch log rule. All logs were sawed on. circle mills and the...

RAYSAW: a log sawing simulator for 3D laser-scanned hardwood logs

Treesearch

R. Edward Thomas

2013-01-01

Laser scanning of hardwood logs provides detailed high-resolution imagery of log surfaces. Characteristics such as sweep, taper, and crook, as well as most surface defects, are visible to the eye in the scan data. In addition, models have been developed that predict interior knot size and position based on external defect information. Computerized processing of...

Density of large snags and logs in northern Arizona mixed-conifer and ponderosa pine forests

Treesearch

Joseph L. Ganey; Benjamin J. Bird; L. Scott Baggett; Jeffrey S. Jenness

2015-01-01

Large snags and logs provide important biological legacies and resources for native wildlife, yet data on populations of large snags and logs and factors influencing those populations are sparse. We monitored populations of large snags and logs in mixed-conifer and ponderosa pine (Pinus ponderosa) forests in northern Arizona from 1997 through 2012. We modeled density...

Log transfer and storage facilities in Southeast Alaska: a review.

Treesearch

Tamra L. Faris; Kenneth D. Vaughan

1985-01-01

The volume of timber harvested in southeast Alaska between 1909 and 1983 was 14,689 million board feet; nearly all was transported on water to various destinations for processing. In 1971 there were 69 active log transfer and storage facilities and 38 raft collecting and storage facilities in southeast Alaska. In 1983 there were 90 log transfer sites, 49 log storage...

SwampLog II: A Structured Journal for Personal and Professional Inquiry within a Collaborative Environment.

ERIC Educational Resources Information Center

Nicassio, Frank J.

SwampLog is a type of journal keeping that records the facts of daily activities as experienced and perceived by practitioners. The label, "SwampLog," was inspired by Donald Schon's metaphor used to distinguish the "swamplands of practice" from the "high, hard ground of research." Keeping a SwampLog consists of recording four general types of…

Predicting internal yellow-poplar log defect features using surface indicators

Treesearch

R. Edward Thomas

2008-01-01

Determining the defects that are located within the log is crucial to understanding the tree/log resource for efficient processing. However, existing means of doing this non-destructively requires the use of expensive X-ray/CT, MRI, or microwave technology. These methods do not lend themselves to fast, efficient, and cost-effective analysis of logs and tree stems in...

Costs of logging thinnings and a clearcutting in Appalachia using a truck-mounted crane

Treesearch

Raymond L. Sarles; Kenneth R. Whitenack

1984-01-01

Four timber cutting treatments - three levels of thinning and a clearcutting - were applied on 60-year-old mountain stands of Allegheny hardwoods. The stands were logged by a three-man crew using chain saws and a truck-mounted crane. Logging operations were studied, and production rates determined for tree-length logs decked at roadside. Work efficiency and...

Soil disturbances from horse/mule logging operations coupled with machines in the Southern United States

Treesearch

Suraj P. Shrestha; Bobby L. Lanford; Robert Rummer; Mark Dubois

2008-01-01

Forest harvesting with animals is a labor-intensive operation. While mechanized logging is very efficient for large tracts of timber, it is often disruptive to the soil. Small logging operations using animals may be less environmentally disruptive. To better understand horse/mule logging performances for soil disturbance, five different horse/mule harvesting operations...

Lumber values from computerized simulation of hardwood log sawing

Treesearch

D.B. Richards; W.K. Adkins; H. Hallock; E.H. Bulgrin

1980-01-01

Computer simulation sawing programs were used to study the sawing of mathematical models of hardwood logs by me live sawing and three 4-sided sawing methods. One of the 4-sided methods simulated "grade sawing" by sawing each successive board from the log face with the highest potential grade. Logs from 10 through 28 inches in diameter were sawn. In addition,...

Interspecies quantitative structure-activity relationships (QSARs) for eco-toxicity screening of chemicals: the role of physicochemical properties.

PubMed

Furuhama, A; Hasunuma, K; Aoki, Y

2015-01-01

In addition to molecular structure profiles, descriptors based on physicochemical properties are useful for explaining the eco-toxicities of chemicals. In a previous study we reported that a criterion based on the difference between the partition coefficient (log POW) and distribution coefficient (log D) values of chemicals enabled us to identify aromatic amines and phenols for which interspecies relationships with strong correlations could be developed for fish-daphnid and algal-daphnid toxicities. The chemicals that met the log D-based criterion were expected to have similar toxicity mechanisms (related to membrane penetration). Here, we investigated the applicability of log D-based criteria to the eco-toxicity of other kinds of chemicals, including aliphatic compounds. At pH 10, use of a log POW - log D > 0 criterion and omission of outliers resulted in the selection of more than 100 chemicals whose acute fish toxicities or algal growth inhibition toxicities were almost equal to their acute daphnid toxicities. The advantage of log D-based criteria is that they allow for simple, rapid screening and prioritizing of chemicals. However, inorganic molecules and chemicals containing certain structural elements cannot be evaluated, because calculated log D values are unavailable.

A stable computation of log-derivatives from noisy drawdown data

NASA Astrophysics Data System (ADS)

Ramos, Gustavo; Carrera, Jesus; Gómez, Susana; Minutti, Carlos; Camacho, Rodolfo

2017-09-01

Pumping tests interpretation is an art that involves dealing with noise coming from multiple sources and conceptual model uncertainty. Interpretation is greatly helped by diagnostic plots, which include drawdown data and their derivative with respect to log-time, called log-derivative. Log-derivatives are especially useful to complement geological understanding in helping to identify the underlying model of fluid flow because they are sensitive to subtle variations in the response to pumping of aquifers and oil reservoirs. The main problem with their use lies in the calculation of the log-derivatives themselves, which may display fluctuations when data are noisy. To overcome this difficulty, we propose a variational regularization approach based on the minimization of a functional consisting of two terms: one ensuring that the computed log-derivatives honor measurements and one that penalizes fluctuations. The minimization leads to a diffusion-like differential equation in the log-derivatives, and boundary conditions that are appropriate for well hydraulics (i.e., radial flow, wellbore storage, fractal behavior, etc.). We have solved this equation by finite differences. We tested the methodology on two synthetic examples showing that a robust solution is obtained. We also report the resulting log-derivative for a real case.

Standard weight (Ws) equations for four rare desert fishes

USGS Publications Warehouse

Didenko, A.V.; Bonar, Scott A.; Matter, W.J.

2004-01-01

Standard weight (Ws) equations have been used extensively to examine body condition in sport fishes. However, development of these equations for nongame fishes has only recently been emphasized. We used the regression-line-percentile technique to develop standard weight equations for four rare desert fishes: flannelmouth sucker Catostomus latipinnis, razorback sucker Xyrauchen texanus, roundtail chub Gila robusta, and humpback chub G. cypha. The Ws equation for flannelmouth suckers of 100-690 mm total length (TL) was developed from 17 populations: log10Ws = -5.180 + 3.068 log10TL. The Ws equation for razorback suckers of 110-885 mm TL was developed from 12 populations: log 10Ws = -4.886 + 2.985 log10TL. The W s equation for roundtail chub of 100-525 mm TL was developed from 20 populations: log10Ws = -5.065 + 3.015 log10TL. The Ws equation for humpback chub of 120-495 mm TL was developed from 9 populations: log10Ws = -5.278 + 3.096 log 10TL. These equations meet criteria for acceptable standard weight indexes and can be used to calculate relative weight, an index of body condition.